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+{"abstract_id": "24290286", "label": "background", "text": "IgE sensitization to Aspergillus fumigatus and a positive sputum fungal culture result are common in patients with refractory asthma .", "sentence_id": 0}
+{"abstract_id": "24290286", "label": "background", "text": "It is not clear whether these patients would benefit from antifungal treatment .", "sentence_id": 1}
+{"abstract_id": "24290286", "label": "objective", "text": "We sought to determine whether a @-month course of voriconazole improved asthma-related outcomes in patients with asthma who are IgE sensitized to A fumigatus .", "sentence_id": 2}
+{"abstract_id": "24290286", "label": "methods", "text": "Asthmatic patients who were IgE sensitized to A fumigatus with a history of at least @ severe exacerbations in the previous @ months were treated for @ months with @ mg of voriconazole twice daily , followed by observation for @ months , in a double-blind , placebo-controlled , randomized design .", "sentence_id": 3}
+{"abstract_id": "24290286", "label": "methods", "text": "Primary outcomes were improvement in quality of life at the end of the treatment period and a reduction in the number of severe exacerbations over the @ months of the study .", "sentence_id": 4}
+{"abstract_id": "24290286", "label": "results", "text": "Sixty-five patients were randomized .", "sentence_id": 5}
+{"abstract_id": "24290286", "label": "results", "text": "Fifty-nine patients started treatment ( @ receiving voriconazole and @ receiving placebo ) and were included in an intention-to-treat analysis .", "sentence_id": 6}
+{"abstract_id": "24290286", "label": "results", "text": "Fifty-six patients took the full @ months of medication .", "sentence_id": 7}
+{"abstract_id": "24290286", "label": "results", "text": "Between the voriconazole and placebo groups , there were no significant differences in the number of severe exacerbations ( @ vs @ per patient per year , respectively ; mean difference , @ ; @ % CI , @-@ @ ) , quality of life ( change in Asthma Quality of Life Questionnaire score , @ vs @ ; mean difference between groups , @ ; @ % CI , -@ to -@ ) , or any of our secondary outcome measures .", "sentence_id": 8}
+{"abstract_id": "24290286", "label": "conclusions", "text": "We were unable to show a beneficial effect of @ months of treatment with voriconazole in patients with moderate-to-severe asthma who were IgE sensitized to A fumigatus on either the rate of severe exacerbations , quality of life , or other markers of asthma control .", "sentence_id": 9}
+{"abstract_id": "24464531", "label": "background", "text": "Opioid antagonists ( e.g. , naltrexone ) and positive modulators of - aminobutyric-acidA ( GABAA ) receptors ( e.g. , alprazolam ) modestly attenuate the abuse-related effects of stimulants like amphetamine .", "sentence_id": 0}
+{"abstract_id": "24464531", "label": "background", "text": "The use of higher doses to achieve greater efficacy is precluded by side effects .", "sentence_id": 1}
+{"abstract_id": "24464531", "label": "background", "text": "Combining naltrexone and alprazolam might safely maximize efficacy while avoiding the untoward effects of the constituent compounds .", "sentence_id": 2}
+{"abstract_id": "24464531", "label": "objective", "text": "The present pilot study tested the hypothesis that acute pretreatment with the combination of naltrexone and alprazolam would not produce clinically problematic physiological effects or negative subjective effects and would reduce the positive subjective effects of d-amphetamine to a greater extent than the constituent drugs alone .", "sentence_id": 3}
+{"abstract_id": "24464531", "label": "methods", "text": "Eight nontreatment-seeking , stimulant-using individuals completed an outpatient experiment in which oral d-amphetamine ( @ , @ , and @ mg ) was administered following acute pretreatment with naltrexone ( @ and @ mg ) and alprazolam ( @ and @ mg ) .", "sentence_id": 4}
+{"abstract_id": "24464531", "label": "methods", "text": "Subjective effects , psychomotor task performance , and physiological measures were collected .", "sentence_id": 5}
+{"abstract_id": "24464531", "label": "results", "text": "Oral d-amphetamine produced prototypical physiological and stimulant-like positive subjective effects ( e.g. , VAS ratings of Active/Alert/Energetic , Good Effect , and High ) .", "sentence_id": 6}
+{"abstract_id": "24464531", "label": "results", "text": "Pretreatment with naltrexone , alprazolam , and their combination did not produce clinically problematic acute physiological effects or negative subjective effects .", "sentence_id": 7}
+{"abstract_id": "24464531", "label": "results", "text": "Naltrexone and alprazolam each significantly attenuated some of the subjective effects of d-amphetamine .", "sentence_id": 8}
+{"abstract_id": "24464531", "label": "results", "text": "The combination attenuated a greater number of subjective effects than the constituent drugs alone .", "sentence_id": 9}
+{"abstract_id": "24464531", "label": "conclusions", "text": "The present results support the continued evaluation of an opioid receptor antagonist combined with a GABAA-positive modulator using more clinically relevant experimental conditions like examining the effect of chronic dosing with these drugs on methamphetamine self-administration .", "sentence_id": 10}
+{"abstract_id": "24494594", "label": "background", "text": "The sequencing of learning materials greatly influences the knowledge that learners construct .", "sentence_id": 0}
+{"abstract_id": "24494594", "label": "background", "text": "Recently , learning theorists have focused on the sequencing of instruction in relation to solving related problems .", "sentence_id": 1}
+{"abstract_id": "24494594", "label": "background", "text": "The general consensus suggests explicit instruction should be provided ; however , when to provide instruction remains unclear .", "sentence_id": 2}
+{"abstract_id": "24494594", "label": "objective", "text": "We tested the impact of conceptual instruction preceding or following mathematics problem solving to determine when conceptual instruction should or should not be delayed .", "sentence_id": 3}
+{"abstract_id": "24494594", "label": "objective", "text": "We also examined the learning processes supported to inform theories of learning more broadly .", "sentence_id": 4}
+{"abstract_id": "24494594", "label": "methods", "text": "We worked with @ second - and third-grade children .", "sentence_id": 5}
+{"abstract_id": "24494594", "label": "methods", "text": "In a randomized experiment , children received instruction on the concept of math equivalence either before or after being asked to solve and explain challenging equivalence problems with feedback .", "sentence_id": 6}
+{"abstract_id": "24494594", "label": "results", "text": "Providing conceptual instruction first resulted in greater procedural knowledge and conceptual knowledge of equation structures than delaying instruction until after problem solving .", "sentence_id": 7}
+{"abstract_id": "24494594", "label": "results", "text": "Prior conceptual instruction enhanced problem solving by increasing the quality of explanations and attempted procedures .", "sentence_id": 8}
+{"abstract_id": "24494594", "label": "conclusions", "text": "Providing conceptual instruction prior to problem solving was the more effective sequencing of activities than the reverse .", "sentence_id": 9}
+{"abstract_id": "24494594", "label": "conclusions", "text": "We compare these results with previous , contrasting findings to outline a potential framework for understanding when instruction should or should not be delayed .", "sentence_id": 10}
+{"abstract_id": "25585595", "label": "background", "text": "Patient adherence to appointments is key to improving outcomes in health care .", "sentence_id": 0}
+{"abstract_id": "25585595", "label": "background", "text": "`` No-show '' appointments contribute to suboptimal resource use .", "sentence_id": 1}
+{"abstract_id": "25585595", "label": "background", "text": "Patient navigation and telephone reminders have been shown to improve cancer care and adherence , particularly in disadvantaged populations , but may not be cost-effective if not targeted at the appropriate patients .", "sentence_id": 2}
+{"abstract_id": "25585595", "label": "methods", "text": "In @ clinics within a large academic cancer center , patients who were considered to be likely ( the top @th percentile ) to miss a scheduled appointment without contacting the clinic ahead of time ( `` no-shows '' ) were identified using a predictive model and then randomized to an intervention versus a usual-care group .", "sentence_id": 3}
+{"abstract_id": "25585595", "label": "methods", "text": "The intervention group received telephone calls from a bilingual patient navigator @ days before and @ day before the appointment .", "sentence_id": 4}
+{"abstract_id": "25585595", "label": "results", "text": "Over a @-month period , of the @,@ appointments scheduled , @ patient appointments were deemed to be at high risk of a `` no-show '' event .", "sentence_id": 5}
+{"abstract_id": "25585595", "label": "results", "text": "After the patient navigation intervention , the no-show rate in the intervention group was @ % ( @ of @ ) , compared with @ % in the control group ( @ of @ ) ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25585595", "label": "results", "text": "Reaching a patient or family member was associated with a significantly lower no-show rate ( @ % and @ % , respectively ; P < @ and @ , respectively ) compared with leaving a message ( @ % : P = @ ) or no contact ( no-show rate , @ % : P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25585595", "label": "conclusions", "text": "Telephone navigation targeted at those patients predicted to be at high risk of visit nonadherence was found to effectively and substantially improve patient adherence to cancer clinic appointments .", "sentence_id": 8}
+{"abstract_id": "25585595", "label": "conclusions", "text": "Further studies are needed to determine the long-term impact on patient outcomes , but short-term gains in the optimization of resources can be recognized immediately .", "sentence_id": 9}
+{"abstract_id": "25344483", "label": "background", "text": "Insufficient skills in drug dose calculations increase the risk for medication errors .", "sentence_id": 0}
+{"abstract_id": "25344483", "label": "background", "text": "Even experienced nurses may struggle with such calculations .", "sentence_id": 1}
+{"abstract_id": "25344483", "label": "background", "text": "Learning flexibility and cost considerations make e-learning interesting as an alternative to classroom teaching .", "sentence_id": 2}
+{"abstract_id": "25344483", "label": "background", "text": "This study compared the learning outcome and risk of error after a course in drug dose calculations for nurses with the two methods .", "sentence_id": 3}
+{"abstract_id": "25344483", "label": "methods", "text": "In a randomised controlled open study , nurses from hospitals and primary healthcare were randomised to either e-learning or classroom teaching .", "sentence_id": 4}
+{"abstract_id": "25344483", "label": "methods", "text": "Before and after a @-day course , the nurses underwent a multiple choice test in drug dose calculations : @ tasks with four alternative answers ( score @-@ ) , and a statement regarding the certainty of each answer ( score @-@ ) .", "sentence_id": 5}
+{"abstract_id": "25344483", "label": "methods", "text": "High risk of error was being certain that incorrect answer was correct .", "sentence_id": 6}
+{"abstract_id": "25344483", "label": "methods", "text": "The results are given as the mean ( SD ) .", "sentence_id": 7}
+{"abstract_id": "25344483", "label": "results", "text": "@ men and @ women participated in the study , aged @ ( @ ) years with a working experience of @ ( @ ) years .", "sentence_id": 8}
+{"abstract_id": "25344483", "label": "results", "text": "The number of correct answers after e-learning was @ ( @ ) and after classroom teaching @ ( @ ) ( p = @ , NS ) ; improvement were @ ( @ ) and @ ( @ ) , respectively ( p = @ , NS ) .", "sentence_id": 9}
+{"abstract_id": "25344483", "label": "results", "text": "Classroom learning was significantly superior to e-learning among participants with a pretest score below @ .", "sentence_id": 10}
+{"abstract_id": "25344483", "label": "results", "text": "In support of e-learning was evaluation of specific value for the working situation .", "sentence_id": 11}
+{"abstract_id": "25344483", "label": "results", "text": "There was no difference in risk of error between groups after the course ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25344483", "label": "conclusions", "text": "The study showed no differences in learning outcome or risk of error between e-learning and classroom teaching in drug dose calculations .", "sentence_id": 13}
+{"abstract_id": "25344483", "label": "conclusions", "text": "The overall learning outcome was small .", "sentence_id": 14}
+{"abstract_id": "25344483", "label": "conclusions", "text": "Weak precourse knowledge was associated with better outcome after classroom teaching .", "sentence_id": 15}
+{"abstract_id": "24917452", "label": "background", "text": "Previous investigation showed that the volume-time curve technique could be an alternative for endotracheal tube ( ETT ) cuff management .", "sentence_id": 0}
+{"abstract_id": "24917452", "label": "background", "text": "However , the clinical impact of the volume-time curve application has not been documented .", "sentence_id": 1}
+{"abstract_id": "24917452", "label": "background", "text": "The purpose of this study was to compare the occurrence and intensity of a sore throat , cough , thoracic pain , and pulmonary function between these @ techniques for ETT cuff management : volume-time curve technique versus minimal occlusive volume ( MOV ) technique after coronary artery bypass grafting .", "sentence_id": 2}
+{"abstract_id": "24917452", "label": "methods", "text": "A total of @ subjects were randomized into @ groups for cuff management after intubation : MOV group ( n = @ ) and volume-time curve group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24917452", "label": "methods", "text": "We measured cuff pressure before extubation .", "sentence_id": 4}
+{"abstract_id": "24917452", "label": "methods", "text": "We performed spirometry @ h before and after surgery .", "sentence_id": 5}
+{"abstract_id": "24917452", "label": "methods", "text": "We graded sore throat and cough according to a @-point scale at @ , @ , @ , and @ h after extubation and assessed thoracic pain at @ h after extubation and quantified the level of pain by a @-point scale .", "sentence_id": 6}
+{"abstract_id": "24917452", "label": "results", "text": "The volume-time curve group presented significantly lower cuff pressure ( @ @ vs @ @ cm H@O ) , less incidence and intensity of sore throat ( @ h , @ vs @ % ; and @ h , @ vs @ % , P < @ ) , cough ( @ h , @ vs @ % ; and @ h , @ vs @ % , P < @ ) , thoracic pain ( @ @ vs @ @ ) , better preservation of FVC ( @ @ vs @ @ % , P = @ ) , and FEV@ ( @ @ vs @ @ % , P = @ ) compared with the MOV group .", "sentence_id": 7}
+{"abstract_id": "24917452", "label": "conclusions", "text": "The subjects who received the volume-time curve technique for ETT cuff management presented a significantly lower incidence and severity of sore throat and cough , less thoracic pain , and minimally impaired pulmonary function than those subjects who received the MOV technique during the first @ h after coronary artery bypass grafting .", "sentence_id": 8}
+{"abstract_id": "25376617", "label": "objective", "text": "To investigate safety and evidence of efficacy of IBI-@ , an intravitreal , liquid , sustained drug delivery system formulated with triamcinolone acetonide ( TA ) in combination with ranibizumab ( Lucentis ) for neovascular age related macular degeneration .", "sentence_id": 0}
+{"abstract_id": "25376617", "label": "methods", "text": "Patients received a single intravitreal injection of IBI-@ containing either @ mg ( @L ) TA or @ mg ( @L ) TA followed a week later by intravitreal injection of @ mg ranibizumab .", "sentence_id": 1}
+{"abstract_id": "25376617", "label": "methods", "text": "Patients were followed monthly and underwent best corrected visual acuity testing , slit lamp biomicroscopy , dilated ophthalmoscopy , fundus photos and optical coherence tomography .", "sentence_id": 2}
+{"abstract_id": "25376617", "label": "methods", "text": "Patients received pro re nata dosing of ranibizumab .", "sentence_id": 3}
+{"abstract_id": "25376617", "label": "results", "text": "Patients ranged in age from @ years to @years ( mean @ years ) and all completed @year follow-up .", "sentence_id": 4}
+{"abstract_id": "25376617", "label": "results", "text": "No serious related adverse events occurred .", "sentence_id": 5}
+{"abstract_id": "25376617", "label": "results", "text": "Ocular adverse events included mild , transient , elevated intraocular pressure in eight patients and cataract progression in three of the five phakic patients .", "sentence_id": 6}
+{"abstract_id": "25376617", "label": "results", "text": "At @year , @ of a total @ ( @ % ) possible pro re nata re-Rx 's had been given .", "sentence_id": 7}
+{"abstract_id": "25376617", "label": "results", "text": "Combination therapy resulted in a median number of @ re-treatments at and including month @ .", "sentence_id": 8}
+{"abstract_id": "25376617", "label": "conclusions", "text": "Combination therapy IBI-@ and ranibizumab was well-tolerated and resulted in fewer ranibizumab retreatments .", "sentence_id": 9}
+{"abstract_id": "25376617", "label": "conclusions", "text": "Transient intraocular pressure elevation and cataract progression occurred .", "sentence_id": 10}
+{"abstract_id": "25710288", "label": "objective", "text": "To estimate age at attaining Tanner stages in Ugandan/Zimbabwean HIV-infected children initiating antiretroviral therapy ( ART ) in older childhood and investigate predictors of delayed puberty , particularly age at ART initiation .", "sentence_id": 0}
+{"abstract_id": "25710288", "label": "methods", "text": "Observational analysis within a randomized trial .", "sentence_id": 1}
+{"abstract_id": "25710288", "label": "methods", "text": "Tanner staging was assessed every @ weeks from @ years of age , menarche every @ weeks and height every @-@ weeks .", "sentence_id": 2}
+{"abstract_id": "25710288", "label": "methods", "text": "Age at attaining different Tanner stages was estimated using normal interval regression , considering predictors using multivariable regression .", "sentence_id": 3}
+{"abstract_id": "25710288", "label": "methods", "text": "Growth was estimated using multilevel models with child-specific intercepts and trajectories .", "sentence_id": 4}
+{"abstract_id": "25710288", "label": "results", "text": "Median age at ART initiation was @ years ( inter-quartile range @ , @ ) ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25710288", "label": "results", "text": "At the first assessment , the majority ( @ % ) were in Tanner stage @ ; median follow-up with staging was @ years .", "sentence_id": 6}
+{"abstract_id": "25710288", "label": "results", "text": "There was a strong delaying effect of older age at ART initiation on age at attaining all Tanner stages ( P < @ ) and menarche ( P = @ ) ; in boys the delaying effect generally weakened with older age .", "sentence_id": 7}
+{"abstract_id": "25710288", "label": "results", "text": "There were additional significant delays associated with greater impairments in pre-ART height-for-age Z-score ( P < @ ) in both sexes and pre-ART BMI-for-age in girls ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25710288", "label": "results", "text": "There was no evidence that pre-ART immuno-suppression independently delayed puberty or menarche .", "sentence_id": 9}
+{"abstract_id": "25710288", "label": "results", "text": "However , older children/adolescents had significant growth spurts in intermediate Tanner stages , and were still significantly increasing their height when in Tanner stage @ ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25710288", "label": "conclusions", "text": "Delaying ART initiation until older childhood substantially delays pubertal development and menarche , independently of immuno-suppression .", "sentence_id": 11}
+{"abstract_id": "25710288", "label": "conclusions", "text": "This highlights that factors other than CD@ , such as pubertal development , need consideration when making decisions about timing of ART initiation in older children .", "sentence_id": 12}
+{"abstract_id": "25255799", "label": "objective", "text": "To assess the effects of a patient oriented decision aid for prioritising treatment goals in diabetes compared with usual care on patient empowerment and treatment decisions .", "sentence_id": 0}
+{"abstract_id": "25255799", "label": "methods", "text": "Pragmatic randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25255799", "label": "methods", "text": "@ general practices in the north of the Netherlands .", "sentence_id": 2}
+{"abstract_id": "25255799", "label": "methods", "text": "@ patients with type @ diabetes aged @ years at the time of diagnosis and managed in primary care between April @ and August @ : @ were allocated to the intervention group and @ to the usual care group .", "sentence_id": 3}
+{"abstract_id": "25255799", "label": "methods", "text": "The intervention comprised a decision aid for people with diabetes , with individually tailored risk information and treatment options for multiple risk factors .", "sentence_id": 4}
+{"abstract_id": "25255799", "label": "methods", "text": "The aid was intended to empower patients to prioritise between clinical domains and to support treatment decisions .", "sentence_id": 5}
+{"abstract_id": "25255799", "label": "methods", "text": "It was offered to participants before a regular diabetes check-up and to their healthcare provider during the consultation .", "sentence_id": 6}
+{"abstract_id": "25255799", "label": "methods", "text": "Four different formats of the decision aid were included for additional explorative analyses .", "sentence_id": 7}
+{"abstract_id": "25255799", "label": "methods", "text": "The primary outcome was the effects on patient empowerment for setting and achieving goals .", "sentence_id": 8}
+{"abstract_id": "25255799", "label": "methods", "text": "The secondary outcomes were changes in the prescribing of drugs to regulate glucose , blood pressure , lipids , and albuminuria .", "sentence_id": 9}
+{"abstract_id": "25255799", "label": "methods", "text": "Data were collected through structured questionnaires and automated data extraction from electronic health records during six months before and after the intervention .", "sentence_id": 10}
+{"abstract_id": "25255799", "label": "results", "text": "Of all intervention participants , @ ( @ % ) reported to have received the basic elements of the intervention .", "sentence_id": 11}
+{"abstract_id": "25255799", "label": "results", "text": "For the primary outcome analysis , @ intervention and @ control patients with sufficient baseline and follow-up data could be included .", "sentence_id": 12}
+{"abstract_id": "25255799", "label": "results", "text": "The mean empowerment score increased @ on a @ point scale in the overall intervention group , which was not significantly different from that of the control group ( mean difference after adjusting for baseline @ , @ % confidence interval -@ to @ ) .", "sentence_id": 13}
+{"abstract_id": "25255799", "label": "results", "text": "Lipid regulating drug treatment was intensified in @ % of intervention and @ % of control participants with increased cholesterol levels , which did not reach significance when the intervention was compared with the usual care group ( odds ratio @ , @ % confidence interval @ to @ ) .", "sentence_id": 14}
+{"abstract_id": "25255799", "label": "results", "text": "Prespecified explorative analyses showed that this effect was significant for the printed version of the decision aid in comparison to usual care ( @ , @ to @ ) .", "sentence_id": 15}
+{"abstract_id": "25255799", "label": "results", "text": "No relevant or significant changes were seen for other treatments .", "sentence_id": 16}
+{"abstract_id": "25255799", "label": "conclusions", "text": "We found no evidence that the patient oriented treatment decision aid improves patient empowerment by an important amount .", "sentence_id": 17}
+{"abstract_id": "25255799", "label": "conclusions", "text": "The aid was not used to its full extent in a substantial number of participants .", "sentence_id": 18}
+{"abstract_id": "26048455", "label": "background", "text": "Bicalutamide blocks androgen action and is frequently used in men with non-metastatic , castration-resistant prostate cancer ( CRPC ) .", "sentence_id": 0}
+{"abstract_id": "26048455", "label": "background", "text": "By reducing intracellular dihydrotestosterone , dutasteride ( dual @-alpha reductase inhibitor ) could increase the effectiveness of bicalutamide in this setting .", "sentence_id": 1}
+{"abstract_id": "26048455", "label": "background", "text": "The objective of the study is therefore to prospectively evaluate dutasteride plus bicalutamide in men with asymptomatic , non-metastatic CRPC with rising prostate-specific antigen ( PSA ) .", "sentence_id": 2}
+{"abstract_id": "26048455", "label": "methods", "text": "Prostate cancer patients with rising PSA whilst on first-line androgen deprivation therapy ( ADT ) were randomised ( @:@ ) in a double-blind trial to receive bicalutamide @mg plus placebo or bicalutamide @mg plus dutasteride @ mg once daily for @ months .", "sentence_id": 3}
+{"abstract_id": "26048455", "label": "methods", "text": "Randomisation was stratified by centre ; treatment assignments were generated using GlaxoSmithKline 's RandAll System .", "sentence_id": 4}
+{"abstract_id": "26048455", "label": "methods", "text": "Subjects who completed @ months could participate in the @-year extension .", "sentence_id": 5}
+{"abstract_id": "26048455", "label": "methods", "text": "Central laboratory and study sites/monitors remained treatment-blinded .", "sentence_id": 6}
+{"abstract_id": "26048455", "label": "methods", "text": "Primary end-point was time to disease progression ( TDP ) up to @ months ( defined as PSA progression from baseline or nadir , radiographic disease progression , death from prostate cancer or receipt of rescue medication ) .", "sentence_id": 7}
+{"abstract_id": "26048455", "label": "results", "text": "There was no statistically significant difference in TDP in @ men treated with bicalutamide/dutasteride ( n = @ ) compared with bicalutamide/placebo ( n = @ ) ( hazard ratio ( HR ) = @ -LSB- @ % confidence interval ( CI ) @ , @ -RSB- ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "26048455", "label": "results", "text": "The estimated median TDP was @ days ( @ % CI @ , @ ) in the bicalutamide/placebo group and @ days ( @ % CI @ , @ ) in the bicalutamide/dutasteride group .", "sentence_id": 9}
+{"abstract_id": "26048455", "label": "results", "text": "There was no statistically significant difference between the treatment groups for any secondary efficacy end-points , including time to treatment failure or PSA response .", "sentence_id": 10}
+{"abstract_id": "26048455", "label": "results", "text": "In the multivariate analysis , age , non-White race , higher baseline testosterone and lower baseline PSA were associated with longer TDP .", "sentence_id": 11}
+{"abstract_id": "26048455", "label": "results", "text": "Adverse events were comparable between treatment groups .", "sentence_id": 12}
+{"abstract_id": "26048455", "label": "conclusions", "text": "In men with non-metastatic CRPC , adding dutasteride to bicalutamide did not significantly prolong TDP .", "sentence_id": 13}
+{"abstract_id": "26048455", "label": "conclusions", "text": "Prospective data are provided concerning the common practice of using bicalutamide in this setting .", "sentence_id": 14}
+{"abstract_id": "25422589", "label": "background", "text": "Menopause is the stage when the menstrual period permanently stops , and is a part of every woman 's life .", "sentence_id": 0}
+{"abstract_id": "25422589", "label": "background", "text": "It usually occurs between the ages of @ and @ years , and is associated with hormonal , physical , and psychological changes .", "sentence_id": 1}
+{"abstract_id": "25422589", "label": "background", "text": "Estrogen and progesterone levels play the biggest part in menopause .", "sentence_id": 2}
+{"abstract_id": "25422589", "label": "background", "text": "In this stage , the ovaries make less estrogen and progesterone .", "sentence_id": 3}
+{"abstract_id": "25422589", "label": "background", "text": "When the body produces less of these hormones , the parts of the body that depend on estrogen to keep them healthy will react and this often causes discomfort for women .", "sentence_id": 4}
+{"abstract_id": "25422589", "label": "background", "text": "This study tested the impact of a complementary health approach to quality of life in menopausal women .", "sentence_id": 5}
+{"abstract_id": "25422589", "label": "methods", "text": "A community-based interventional study was conducted in selected areas in Kattankulathur Block , Kanchipuram District , Tamil Nadu , India .", "sentence_id": 6}
+{"abstract_id": "25422589", "label": "methods", "text": "A simple random sampling technique was used to select menopausal women for the study .", "sentence_id": 7}
+{"abstract_id": "25422589", "label": "methods", "text": "Of @ menopausal women identified , @ were allocated to a study group and @ to a control group .", "sentence_id": 8}
+{"abstract_id": "25422589", "label": "methods", "text": "The study group underwent yoga training for @ hours per day on @ consecutive days .", "sentence_id": 9}
+{"abstract_id": "25422589", "label": "methods", "text": "After the @-day intensive yoga training program , the menopausal women practiced yoga daily at home for @-@ minutes a day .", "sentence_id": 10}
+{"abstract_id": "25422589", "label": "methods", "text": "Along with daily yoga practice , they underwent group yoga practice for @ days a week under the supervision of one of the investigators until @ weeks .", "sentence_id": 11}
+{"abstract_id": "25422589", "label": "methods", "text": "The yoga training program consisted of Yogasanas , Pranayama ( breathing exercises ) , and meditation .", "sentence_id": 12}
+{"abstract_id": "25422589", "label": "methods", "text": "The standardized World Health Organization QoL BREF scale was used to assess the women 's quality of life .", "sentence_id": 13}
+{"abstract_id": "25422589", "label": "methods", "text": "We distributed an instruction manual on steps of selected yoga practice for the women 's self-reference at home after the @ days of continuous yoga practice .", "sentence_id": 14}
+{"abstract_id": "25422589", "label": "methods", "text": "A yoga practice diary was used to confirm regular performance of yoga .", "sentence_id": 15}
+{"abstract_id": "25422589", "label": "methods", "text": "The women in the control group did not participate in the yoga program ; however , on completion of the study , these women received intensive yoga training for @ days .", "sentence_id": 16}
+{"abstract_id": "25422589", "label": "results", "text": "There was an extremely high statistically significant difference ( P = @ ) between the study group and the control group with regard to the physical , psychological , social , and environmental domains of quality of life after @ , @ , and @ weeks of yoga therapy .", "sentence_id": 17}
+{"abstract_id": "25422589", "label": "results", "text": "The mean gain score was high in all the domains of quality of life in the study group at weeks @ , @ , and @ .", "sentence_id": 18}
+{"abstract_id": "25422589", "label": "results", "text": "The overall mean gain score in the study group was @ versus @ in the control group .", "sentence_id": 19}
+{"abstract_id": "25422589", "label": "results", "text": "The overall mean gain score difference was @ in all domains of quality of life between the study group and the control group .", "sentence_id": 20}
+{"abstract_id": "25422589", "label": "results", "text": "In the study group , the physical , psychological , social , and environmental domains of quality of life were greatly improved by practicing yoga for @ weeks .", "sentence_id": 21}
+{"abstract_id": "25422589", "label": "results", "text": "No adverse events were reported by the women after yoga practice .", "sentence_id": 22}
+{"abstract_id": "25422589", "label": "conclusions", "text": "Quality of life in menopausal women was greatly improved after @ weeks of yoga practice .", "sentence_id": 23}
+{"abstract_id": "25422589", "label": "conclusions", "text": "Women who regularly practice yoga find that they are able to enjoy menopause and experience the freedom , liberation , and energy that it brings .", "sentence_id": 24}
+{"abstract_id": "25422589", "label": "conclusions", "text": "We conclude that yoga is an effective complementary health approach for improving quality of life in menopausal women .", "sentence_id": 25}
+{"abstract_id": "24928802", "label": "background", "text": "Constipation has a significant impact on quality of life .", "sentence_id": 0}
+{"abstract_id": "24928802", "label": "background", "text": "Aim of this study was to evaluate the safety and the efficacy for relieving dyschezia symptoms of a CO@-releasing suppository in a randomized , placebo-controlled , clinical trial .", "sentence_id": 1}
+{"abstract_id": "24928802", "label": "methods", "text": "Fifty-three office-based primary care physicians and @ gastroenterologists conducted the study in France , between November @ and January @ .", "sentence_id": 2}
+{"abstract_id": "24928802", "label": "methods", "text": "Patients ( aged @-@ years ) with dyschezia were eligible .", "sentence_id": 3}
+{"abstract_id": "24928802", "label": "methods", "text": "Patients were randomly allocated a once-a-day suppository ( CO@-releasing suppository or placebo ) for @ days .", "sentence_id": 4}
+{"abstract_id": "24928802", "label": "methods", "text": "Primary endpoint was the change , from Day @ to Day @ , in the intensity of discomfort related to dyschezia based on a self-assessed @-@ visual analogue scale .", "sentence_id": 5}
+{"abstract_id": "24928802", "label": "results", "text": "A total of @ patients were randomized , i.e. @ into the intervention group and @ into the placebo group .", "sentence_id": 6}
+{"abstract_id": "24928802", "label": "results", "text": "Co-variance analysis showed a greater reduction in discomfort visual analogue scale score in the intervention group ( -@ mm ; standard error of the mean : @ mm ) than in the placebo group ( -@ mm ; standard error of the mean : @ mm ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24928802", "label": "results", "text": "The greater efficacy of the CO@-releasing suppository was confirmed for all secondary efficacy parameters .", "sentence_id": 8}
+{"abstract_id": "24928802", "label": "results", "text": "No significant side effects for either treatment were observed .", "sentence_id": 9}
+{"abstract_id": "24928802", "label": "conclusions", "text": "A CO@-releasing suppository is more effective than a placebo for the relief of symptoms of dyschezia .", "sentence_id": 10}
+{"abstract_id": "24928802", "label": "conclusions", "text": "This efficacy is associated with a good safety profile .", "sentence_id": 11}
+{"abstract_id": "24499812", "label": "background", "text": "Tubal ectopic pregnancy can be surgically treated by salpingectomy , in which the affected Fallopian tube is removed , or salpingotomy , in which the tube is preserved .", "sentence_id": 0}
+{"abstract_id": "24499812", "label": "background", "text": "Despite potentially increased risks of persistent trophoblast and repeat ectopic pregnancy , salpingotomy is often preferred over salpingectomy because the preservation of both tubes is assumed to offer favourable fertility prospects , although little evidence exists to support this assumption .", "sentence_id": 1}
+{"abstract_id": "24499812", "label": "background", "text": "We aimed to assess whether salpingotomy would improve rates of ongoing pregnancy by natural conception compared with salpingectomy .", "sentence_id": 2}
+{"abstract_id": "24499812", "label": "methods", "text": "In this open-label , multicentre , international , randomised controlled trial , women aged @ years and older with a laparoscopically confirmed tubal pregnancy and a healthy contralateral tube were randomly assigned via a central internet-based randomisation program to receive salpingotomy or salpingectomy .", "sentence_id": 3}
+{"abstract_id": "24499812", "label": "methods", "text": "The primary outcome was ongoing pregnancy by natural conception .", "sentence_id": 4}
+{"abstract_id": "24499812", "label": "methods", "text": "Differences in cumulative ongoing pregnancy rates were expressed as a fecundity rate ratio with @ % CI , calculated by Cox proportional-hazards analysis with a time horizon of @ months .", "sentence_id": 5}
+{"abstract_id": "24499812", "label": "methods", "text": "Secondary outcomes were persistent trophoblast and repeat ectopic pregnancy ( expressed as relative risks -LSB- RRs -RSB- with @ % CIs ) and ongoing pregnancy after ovulation induction , intrauterine insemination , or IVF .", "sentence_id": 6}
+{"abstract_id": "24499812", "label": "methods", "text": "The researchers who collected data for fertility outcomes were masked to the assigned intervention , but patients and the investigators who analysed the data were not .", "sentence_id": 7}
+{"abstract_id": "24499812", "label": "methods", "text": "All endpoints were analysed by intention to treat .", "sentence_id": 8}
+{"abstract_id": "24499812", "label": "methods", "text": "We also did a ( non-prespecified ) meta-analysis that included the findings from the present trial .", "sentence_id": 9}
+{"abstract_id": "24499812", "label": "methods", "text": "This trial is registered , number ISRCTN@ .", "sentence_id": 10}
+{"abstract_id": "24499812", "label": "results", "text": "@ women were randomly assigned between Sept @ , @ , and Nov @ , @ , with @ allocated to salpingotomy and @ to salpingectomy .", "sentence_id": 11}
+{"abstract_id": "24499812", "label": "results", "text": "Follow-up was discontinued on Feb @ , @ .", "sentence_id": 12}
+{"abstract_id": "24499812", "label": "results", "text": "The cumulative ongoing pregnancy rate was @ % after salpingotomy and @ % after salpingectomy ( fecundity rate ratio @ , @ % CI @-@ ; log-rank p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24499812", "label": "results", "text": "Persistent trophoblast occurred more frequently in the salpingotomy group than in the salpingectomy group ( @ -LSB- @ % -RSB- vs @ -LSB- < @ % -RSB- ; RR @ , @-@ ) .", "sentence_id": 14}
+{"abstract_id": "24499812", "label": "results", "text": "Repeat ectopic pregnancy occurred in @ women ( @ % ) in the salpingotomy group and @ ( @ % ) women in the salpingectomy group ( RR @ , @-@ ) .", "sentence_id": 15}
+{"abstract_id": "24499812", "label": "results", "text": "The number of ongoing pregnancies after ovulation induction , intrauterine insemination , or IVF did not differ significantly between the groups .", "sentence_id": 16}
+{"abstract_id": "24499812", "label": "results", "text": "@ ( @ % ) women in the salpingotomy group were converted to salpingectomy during the initial surgery because of persistent tubal bleeding .", "sentence_id": 17}
+{"abstract_id": "24499812", "label": "results", "text": "Our meta-analysis , which included our own results and those of one other study , substantiated the results of the trial .", "sentence_id": 18}
+{"abstract_id": "24499812", "label": "conclusions", "text": "In women with a tubal pregnancy and a healthy contralateral tube , salpingotomy does not significantly improve fertility prospects compared with salpingectomy .", "sentence_id": 19}
+{"abstract_id": "24270743", "label": "objective", "text": "To examine the diagnostic accuracy of novel biomarkers of myocardial injury and troponin assays for diagnosis of myocardial infarction .", "sentence_id": 0}
+{"abstract_id": "24270743", "label": "methods", "text": "@ patients randomised to the point-of-care testing arm of the Randomised Assessment of Panel Assay of Cardiac markers ( RATPAC ) study in six emergency departments of low-risk patients presenting with chest pain were studied .", "sentence_id": 1}
+{"abstract_id": "24270743", "label": "methods", "text": "Blood samples were obtained on admission and @ min from admission .", "sentence_id": 2}
+{"abstract_id": "24270743", "label": "methods", "text": "Myocardial infarction was defined by the universal definition of myocardial infarction .", "sentence_id": 3}
+{"abstract_id": "24270743", "label": "methods", "text": "The following diagnostic strategies were compared by receiver operator characteristic curve analysis and comparison of area under the curve : individual marker values and the combination of presentation heart fatty acid binding protein ( HFABP ) and copeptin with troponin .", "sentence_id": 4}
+{"abstract_id": "24270743", "label": "results", "text": "@ patients had a final diagnosis of myocardial infarction .", "sentence_id": 5}
+{"abstract_id": "24270743", "label": "results", "text": "Admission samples were available from @/@ patients enrolled in the study .", "sentence_id": 6}
+{"abstract_id": "24270743", "label": "results", "text": "Areas under the curve were as follows ( CIs in parentheses ) : cardiac troponin I ( cTnI ) Stratus CS @ ( @ to @ ) , cTnI Beckmann @ ( @ to @ ) , cTnI Siemens ultra @ ( @ to @ ) , cardiac troponin T high sensitivity @ ( @ to @ ) , HFABP @ @ ( @ to @ ) copeptin @ ( @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "24270743", "label": "results", "text": "HFABP and copeptin were diagnostically inferior to troponin .", "sentence_id": 8}
+{"abstract_id": "24270743", "label": "results", "text": "The combination of HFABP ( at the @th percentile ) and troponin ( at the @th percentile ) increased diagnostic sensitivity .", "sentence_id": 9}
+{"abstract_id": "24270743", "label": "conclusions", "text": "High-sensitivity cardiac troponin is the best single marker .", "sentence_id": 10}
+{"abstract_id": "24270743", "label": "conclusions", "text": "Addition of HFABP to high-sensitivity troponin increased diagnostic sensitivity .", "sentence_id": 11}
+{"abstract_id": "24270743", "label": "conclusions", "text": "Additional measurement of copeptin is not useful in the chest pain population .", "sentence_id": 12}
+{"abstract_id": "25031187", "label": "background", "text": "Multidimensional tinnitus models describe dysfunctional cognitions as a complicating factor in the process of tinnitus habituation .", "sentence_id": 0}
+{"abstract_id": "25031187", "label": "background", "text": "However , this concept has rarely been investigated in previous research .", "sentence_id": 1}
+{"abstract_id": "25031187", "label": "objective", "text": "The present study investigated the effects of two cognitive-behavioral treatments on dysfunctional tinnitus-related cognitions in patients with chronic tinnitus .", "sentence_id": 2}
+{"abstract_id": "25031187", "label": "objective", "text": "Furthermore , dysfunctional cognitions were examined as possible predictors of the therapeutic effect on tinnitus distress .", "sentence_id": 3}
+{"abstract_id": "25031187", "label": "methods", "text": "A total of @ patients with chronic tinnitus were randomly assigned to either an Internet-delivered guided self-help treatment ( Internet-based cognitive-behavioral therapy , ICBT ) , a conventional face-to-face group therapy ( cognitive-behavioral group therapy , GCBT ) , or an active control group in the form of a web-based discussion forum ( DF ) .", "sentence_id": 4}
+{"abstract_id": "25031187", "label": "methods", "text": "To assess tinnitus-related dysfunctional thoughts , the Tinnitus Cognitions Scale ( T-Cog ) was used at pre - and post-assessment , as well as at the @ - and @-month follow-up .", "sentence_id": 5}
+{"abstract_id": "25031187", "label": "results", "text": "Multivariate ANOVAs with post hoc tests revealed significant and comparable reductions of dysfunctional tinnitus-related cognitions for both treatments ( GCBT and ICBT ) , which remained stable over a @ - and @-month period .", "sentence_id": 6}
+{"abstract_id": "25031187", "label": "results", "text": "Negative correlations were found between the catastrophic subscale of the T-Cog and therapy outcome for ICBT , but not for GCBT .", "sentence_id": 7}
+{"abstract_id": "25031187", "label": "results", "text": "This means a higher degree of catastrophic thinking at baseline was associated with lower benefit from ICBT directly after the treatment .", "sentence_id": 8}
+{"abstract_id": "25031187", "label": "results", "text": "Hierarchical regression analysis confirmed catastrophizing as a predictor of poorer therapy outcome regarding emotional tinnitus distress in ICBT .", "sentence_id": 9}
+{"abstract_id": "25031187", "label": "results", "text": "No associations were detected in the follow-up assessments .", "sentence_id": 10}
+{"abstract_id": "25031187", "label": "conclusions", "text": "Both forms of CBT are successful in reducing dysfunctional tinnitus-related cognitions .", "sentence_id": 11}
+{"abstract_id": "25031187", "label": "conclusions", "text": "Catastrophizing significantly predicted a less favorable outcome regarding emotional tinnitus distress in ICBT .", "sentence_id": 12}
+{"abstract_id": "25031187", "label": "conclusions", "text": "Clinical implications of these results are described .", "sentence_id": 13}
+{"abstract_id": "25031187", "label": "conclusions", "text": "Dysfunctional cognitions could be targeted more intensively in therapy and in future research on tinnitus .", "sentence_id": 14}
+{"abstract_id": "24706369", "label": "objective", "text": "Handling emergency telephone consultations ( ETCs ) is a challenging and very important task for doctors .", "sentence_id": 0}
+{"abstract_id": "24706369", "label": "objective", "text": "The aims of the study were to document insecurity in medical students during ETCs and to identify the reasons for that insecurity .", "sentence_id": 1}
+{"abstract_id": "24706369", "label": "objective", "text": "We hypothesised that insecurity is associated with advising more urgent action ( e.g. advice to call for an ambulance ) in ETCs .", "sentence_id": 2}
+{"abstract_id": "24706369", "label": "methods", "text": "We used ETCs with simulated patients ( SPs ) , with each student randomly allocated two of four possible cases .", "sentence_id": 3}
+{"abstract_id": "24706369", "label": "methods", "text": "After the training , @ students reported on any insecurity that they had in the various ETC phases .", "sentence_id": 4}
+{"abstract_id": "24706369", "label": "methods", "text": "We analysed the reasons for insecurity using descriptive statistics .", "sentence_id": 5}
+{"abstract_id": "24706369", "label": "methods", "text": "The association between the students ' advice that urgent action was needed and their insecurity was analysed with Spearman rank correlation .", "sentence_id": 6}
+{"abstract_id": "24706369", "label": "results", "text": "Overall , @ % of the students felt insecure in at least one phase of their ETC. .", "sentence_id": 7}
+{"abstract_id": "24706369", "label": "results", "text": "History taking was the phase in which students felt most insecure ( @ % ) , followed by the phase of analysing the information given by the patient ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24706369", "label": "results", "text": "Perceived insecurity was associated with more urgent advice in one case scenario ( abdominal pain ; correlation r = @ ; p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24706369", "label": "results", "text": "The other two cases ( child with fever ; chest pain ) also had a positive , but not statistically significant , correlation trend ( p < @ ; p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24706369", "label": "conclusions", "text": "Insecurity is highly prevalent among medical students in their ETC decision-making .", "sentence_id": 11}
+{"abstract_id": "24706369", "label": "conclusions", "text": "ETC training in medical schools , with a focus on structured history taking and formulating discriminating questions , might help decrease insecurity in ETCs .", "sentence_id": 12}
+{"abstract_id": "24706369", "label": "conclusions", "text": "Medical education should also teach management of insecurity .", "sentence_id": 13}
+{"abstract_id": "25511347", "label": "objective", "text": "We investigated the efficacy of intravenous ( IV ) preemptive paracetamol on postoperative total fentanyl consumption and fentanyl-related side effects in patients undergoing open nephrectomy .", "sentence_id": 0}
+{"abstract_id": "25511347", "label": "methods", "text": "A total of @ patients scheduled for elective open nephrectomy under general anesthesia were included .", "sentence_id": 1}
+{"abstract_id": "25511347", "label": "methods", "text": "All patients received Patient-controlled IV analgesia with fentanyl postoperatively .", "sentence_id": 2}
+{"abstract_id": "25511347", "label": "methods", "text": "Patients were randomly allocated into three equal groups : The fentanyl group received @ mL of IV normal saline as a placebo , with the first dose ending @ min before intubation .", "sentence_id": 3}
+{"abstract_id": "25511347", "label": "methods", "text": "In paracetamol group , IV @ g paracetamol was given to the patients @ min after extubation with repeated doses every @ h totally @ times a day .", "sentence_id": 4}
+{"abstract_id": "25511347", "label": "methods", "text": "In preemptive paracetamol group , patients received IV @ g paracetamol every @ h , with the first dose ending @ min before intubation .", "sentence_id": 5}
+{"abstract_id": "25511347", "label": "results", "text": "Postoperative cumulative fentanyl consumption for @ h was significantly higher in the fentanyl group ( @ @ g ) than those of paracetamol ( @ @ g ) and preemptive paracetamol groups ( @ @ g ) ( P = @ for both ) .", "sentence_id": 6}
+{"abstract_id": "25511347", "label": "results", "text": "In early postoperative period ( @-@ h ) ; whereas total fentanyl consumption showed no statistically significant difference among groups ( P = @ ) , the nausea-vomiting scores were significantly higher in the fentanyl group compared with other groups ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25511347", "label": "conclusions", "text": "In patients undergoing open nephrectomy , use of preemptive or postoperative paracetamol reduces fentanyl related nausea-vomiting without a decrease in total fentanyl consumption in the early postoperative period .", "sentence_id": 8}
+{"abstract_id": "25511347", "label": "conclusions", "text": "Furthermore , use of preemptive or postoperative paracetamol reduces total fentanyl requirements in the first @ h postoperatively providing a safe and effective postoperative analgesia .", "sentence_id": 9}
+{"abstract_id": "25677309", "label": "background", "text": "Brain lesions on diffusion-weighted imaging ( DWI ) are frequently found after carotid artery stenting ( CAS ) , but their clinical relevance remains unclear .", "sentence_id": 0}
+{"abstract_id": "25677309", "label": "objective", "text": "This study sought to investigate whether periprocedural ischemic DWI lesions after CAS or carotid endarterectomy ( CEA ) are associated with an increased risk of recurrent cerebrovascular events .", "sentence_id": 1}
+{"abstract_id": "25677309", "label": "methods", "text": "In the magnetic resonance imaging ( MRI ) substudy of ICSS ( International Carotid Stenting Study ) , @ patients with symptomatic carotid stenosis were randomized to undergo CAS ( n = @ ) or CEA ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25677309", "label": "methods", "text": "MRIs were performed @ to @ days before and @ to @ days after treatment .", "sentence_id": 3}
+{"abstract_id": "25677309", "label": "methods", "text": "The primary outcome event was stroke or transient ischemic attack in any territory occurring between the post-treatment MRI and the end of follow-up .", "sentence_id": 4}
+{"abstract_id": "25677309", "label": "methods", "text": "Time to occurrence of the primary outcome event was compared between patients with ( DWI + ) and without ( DWI - ) new DWI lesions on the post-treatment scan in the CAS and CEA groups separately .", "sentence_id": 5}
+{"abstract_id": "25677309", "label": "results", "text": "Median time of follow-up was @ years ( interquartile range : @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25677309", "label": "results", "text": "In the CAS group , recurrent stroke or transient ischemic attack occurred more often among DWI + patients ( @ of @ ) than among DWI - patients ( @ of @ ) , with a cumulative @-year incidence of @ % ( standard error -LSB- SE -RSB- : @ % ) and @ % ( SE : @ % ) , respectively ( unadjusted hazard ratio : @ ; @ % confidence interval : @ to @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25677309", "label": "results", "text": "In DWI + and DWI - patients , @ and @ events , respectively , occurred within @ months after treatment .", "sentence_id": 8}
+{"abstract_id": "25677309", "label": "results", "text": "In the CEA group , there was no difference in recurrent cerebrovascular events between DWI + and DWI - patients .", "sentence_id": 9}
+{"abstract_id": "25677309", "label": "conclusions", "text": "Ischemic brain lesions discovered on DWI after CAS seem to be a marker of increased risk for recurrent cerebrovascular events .", "sentence_id": 10}
+{"abstract_id": "25677309", "label": "conclusions", "text": "Patients with periprocedural DWI lesions might benefit from more aggressive and prolonged antiplatelet therapy after CAS .", "sentence_id": 11}
+{"abstract_id": "25677309", "label": "conclusions", "text": "( A Randomised Comparison of the Risks , Benefits and Cost Effectiveness of Primary Carotid Stenting With Carotid Endarterectomy : International Carotid Stenting Study ; ISRCTN@ ) .", "sentence_id": 12}
+{"abstract_id": "25817472", "label": "background", "text": "Misoprostol is established for the treatment of incomplete abortion but has not been systematically assessed when provided by midwives at district level in a low-resource setting .", "sentence_id": 0}
+{"abstract_id": "25817472", "label": "background", "text": "We investigated the effectiveness and safety of midwives diagnosing and treating incomplete abortion with misoprostol , compared with physicians .", "sentence_id": 1}
+{"abstract_id": "25817472", "label": "methods", "text": "We did a multicentre randomised controlled equivalence trial at district level at six facilities in Uganda .", "sentence_id": 2}
+{"abstract_id": "25817472", "label": "methods", "text": "Eligibility criteria were women with signs of incomplete abortion .", "sentence_id": 3}
+{"abstract_id": "25817472", "label": "methods", "text": "We randomly allocated women with first-trimester incomplete abortion to clinical assessment and treatment with misoprostol either by a physician or a midwife .", "sentence_id": 4}
+{"abstract_id": "25817472", "label": "methods", "text": "The randomisation ( @:@ ) was done in blocks of @ and was stratified for study site .", "sentence_id": 5}
+{"abstract_id": "25817472", "label": "methods", "text": "Primary outcome was complete abortion not needing surgical intervention within @-@ days after initial treatment .", "sentence_id": 6}
+{"abstract_id": "25817472", "label": "methods", "text": "The study was not masked .", "sentence_id": 7}
+{"abstract_id": "25817472", "label": "methods", "text": "Analysis of the primary outcome was done on the per-protocol population with a generalised linear-mixed effects model .", "sentence_id": 8}
+{"abstract_id": "25817472", "label": "methods", "text": "The predefined equivalence range was -@ % to @ % .", "sentence_id": 9}
+{"abstract_id": "25817472", "label": "methods", "text": "The trial was registered at ClinicalTrials.gov , number NCT@ .", "sentence_id": 10}
+{"abstract_id": "25817472", "label": "results", "text": "From April @ , @ , to July @ , @ , @ women were assessed for eligibility .", "sentence_id": 11}
+{"abstract_id": "25817472", "label": "results", "text": "@ women were randomly assigned to each group ( @ to midwife group and @ to physician group ) .", "sentence_id": 12}
+{"abstract_id": "25817472", "label": "results", "text": "@ women ( @ in the midwife group and @ in the physician group ) were included in the per-protocol analysis .", "sentence_id": 13}
+{"abstract_id": "25817472", "label": "results", "text": "@ ( @ % ) of women in the midwife group had complete abortion and @ ( @ % ) in the physician group .", "sentence_id": 14}
+{"abstract_id": "25817472", "label": "results", "text": "The model-based risk difference for midwife versus physician group was -@ % ( @ % CI -@ to @ ) , falling within the predefined equivalence range ( -@ % to @ % ) .", "sentence_id": 15}
+{"abstract_id": "25817472", "label": "results", "text": "The overall proportion of women with incomplete abortion was @ % ( @/@ ) , similarly distributed between the two groups ( @ % -LSB- @/@ -RSB- in the midwife group , @ % -LSB- @/@ -RSB- in the physician group ) .", "sentence_id": 16}
+{"abstract_id": "25817472", "label": "results", "text": "No serious adverse events were recorded .", "sentence_id": 17}
+{"abstract_id": "25817472", "label": "conclusions", "text": "Diagnosis and treatment of incomplete abortion with misoprostol by midwives is equally safe and effective as when provided by physicians , in a low-resource setting .", "sentence_id": 18}
+{"abstract_id": "25817472", "label": "conclusions", "text": "Scaling up midwives ' involvement in treatment of incomplete abortion with misoprostol at district level would increase access to safe post-abortion care .", "sentence_id": 19}
+{"abstract_id": "24398076", "label": "background", "text": "Much of the existing literature on physical activity ( PA ) interventions involves physically inactive individuals recruited from community settings rather than clinical practice settings .", "sentence_id": 0}
+{"abstract_id": "24398076", "label": "background", "text": "Recruitment of patients into interventions in clinical practice settings is difficult due to limited time available in the clinic , identification of appropriate personnel to efficiently conduct the process , and time-consuming methods of recruitment .", "sentence_id": 1}
+{"abstract_id": "24398076", "label": "background", "text": "The purpose of this report is to describe the approach used to identify and recruit veterans from the Veterans Affairs ( VA ) Pittsburgh Healthcare System Primary Care Clinic into a randomized controlled PA study .", "sentence_id": 2}
+{"abstract_id": "24398076", "label": "methods", "text": "A sampling frame of veterans was developed using the VA electronic medical record .", "sentence_id": 3}
+{"abstract_id": "24398076", "label": "methods", "text": "During regularly scheduled clinic appointments , primary care providers ( PCPs ) screened identified patients for safety to engage in moderate-intensity PA and willingness to discuss the study with research staff members .", "sentence_id": 4}
+{"abstract_id": "24398076", "label": "methods", "text": "Research staff determined eligibility with a subsequent telephone screening call and scheduled a research study appointment , at which time signed informed consent and baseline measurements were obtained .", "sentence_id": 5}
+{"abstract_id": "24398076", "label": "results", "text": "Of the @,@ veterans in the sampling frame who were scheduled for a primary care appointment during the study period , @,@ ( @ % ) were seen in the clinic and screened by the PCP ; moderate-intensity PA was deemed safe for @,@ ( @ % ) , @ ( @ % ) agreed to be contacted for further screening , @ ( @ % ) were eligible for the study , and @ ( @ % ) enrolled .", "sentence_id": 6}
+{"abstract_id": "24398076", "label": "conclusions", "text": "Using a semiautomated screening approach that combined an electronically-derived sampling frame with paper and pencil prescreening by PCPs and research staff , VA-STRIDE was able to recruit @ in @ veterans in the sampling frame .", "sentence_id": 7}
+{"abstract_id": "24398076", "label": "conclusions", "text": "Using this approach , a high proportion of potentially eligible veterans were screened by their PCPs .", "sentence_id": 8}
+{"abstract_id": "24700403", "label": "objective", "text": "We tested the hypothesis that clevidipine , a rapidly acting dihydropyridine calcium channel blocker , is not inferior to nitroglycerin ( NTG ) in controlling blood pressure before cardiopulmonary bypass ( CPB ) during coronary artery bypass grafting ( CABG ) .", "sentence_id": 0}
+{"abstract_id": "24700403", "label": "methods", "text": "In this double-blind study from October @ , @ to April @ , @ , @ patients undergoing CABG with CPB were randomized at four centres to receive intravenous infusions of clevidipine ( @-@gkg ( -@ ) min ( -@ ) ) or NTG ( @ gkg ( -@ ) min ( -@ ) to a clinician-determined maximum dose rate ) from induction of anesthesia through @hr postoperatively .", "sentence_id": 1}
+{"abstract_id": "24700403", "label": "methods", "text": "The study drug was titrated in the pre-CPB period with the aim of maintaining mean arterial pressure ( MAP ) within @mmHg of a clinician-predetermined target .", "sentence_id": 2}
+{"abstract_id": "24700403", "label": "methods", "text": "The primary endpoint was the area under the curve ( AUC ) for the total time each patient 's MAP was outside the target range from drug initiation to the start of CPB , normalized per hour ( AUCMAP-D ) .", "sentence_id": 3}
+{"abstract_id": "24700403", "label": "methods", "text": "The predefined non-inferiority criterion for the primary endpoint was a @ % confidence interval ( CI ) upper limit no greater than @ for the geometric means ratio between clevidipine and NTG .", "sentence_id": 4}
+{"abstract_id": "24700403", "label": "results", "text": "Total mean -LSB- standard deviation ( SD ) -RSB- dose pre-bypass was @ ( @ ) mg for clevidipine and @ ( @ ) mg for NTG ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24700403", "label": "results", "text": "The geometric mean AUCMAP-D for clevidipine was @mmHgminhr ( -@ ) ( n = @ ) and for NTG was @mmHgminhr ( -@ ) ( n = @ ) ; the geometric means ratio was @ ( @ % CI @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "24700403", "label": "results", "text": "The geometric mean AUCMAP-D during aortic cannulation was @ mmHgminhr ( -@ ) for clevidipine compared with @ mmHgminhr ( -@ ) for NTG .", "sentence_id": 7}
+{"abstract_id": "24700403", "label": "results", "text": "Mean ( SD ) heart rate with clevidipine was @ ( @ ) beatsmin ( -@ ) compared with @ ( @ ) beatsmin ( -@ ) for NTG .", "sentence_id": 8}
+{"abstract_id": "24700403", "label": "results", "text": "There were no clinically important differences between groups in adverse events .", "sentence_id": 9}
+{"abstract_id": "24700403", "label": "conclusions", "text": "During CABG , clevidipine was not inferior to NTG for blood pressure control pre-bypass .", "sentence_id": 10}
+{"abstract_id": "25877711", "label": "objective", "text": "To observe the efficacy of bromfenac sodium eye drops on relieving the irritative symptoms after LASEK surgery .", "sentence_id": 0}
+{"abstract_id": "25877711", "label": "methods", "text": "Sixty-four people who had received LASEK surgery were randomly divided into two groups , observing the right eye for each group .", "sentence_id": 1}
+{"abstract_id": "25877711", "label": "methods", "text": "group A was given @ % bromfenac sodium eye drops twice a day in three days before surgery and one day after surgery ; group B was given @ % ketorolac tromethamine ( acular ) eye drops four times a day in three days before surgery and on day after surgery .", "sentence_id": 2}
+{"abstract_id": "25877711", "label": "methods", "text": "In the @ ( st ) , @ ( rd ) , @ ( th ) and @ ( th ) day after surgery , irritative symptoms grade , duration of irritation , time for corneal epithelial healing , and uncorrected visual acuity were observed and compared between the two groups .", "sentence_id": 3}
+{"abstract_id": "25877711", "label": "results", "text": "@ % no discomfort in group A with bromfenac sodium eye drops was observed while @ % ketorolac tromethamine eye drops caused tingling , burning discomfort that lasted for @-@ seconds in @ of the @ subjects ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "25877711", "label": "results", "text": "No significant difference was observed between the irritation grades of group A and B ( Z = -@ , P = @ ) ; the duration of irritative symptom was significantly shorter in group A than that in group B ( Z = -@ , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25877711", "label": "results", "text": "No significant difference was observed between the time of healing and visual acuity recovery of the two groups .", "sentence_id": 6}
+{"abstract_id": "25877711", "label": "conclusions", "text": "@ % bromfenac sodium eye drops can effectively relieve the post-LASEK irritative symptoms , and it is better tolerated than @ % ketorolac tromethamine eye drops .", "sentence_id": 7}
+{"abstract_id": "25248497", "label": "background", "text": "Postnatal common mental disorders among women are an important public health problem internationally .", "sentence_id": 0}
+{"abstract_id": "25248497", "label": "background", "text": "Interventions to prevent postnatal depression have had limited success .", "sentence_id": 1}
+{"abstract_id": "25248497", "label": "background", "text": "What Were We Thinking ( WWWT ) is a structured , gender-informed , psychoeducational group programme for parents and their first infant that addresses two modifiable risks to postnatal mental health .", "sentence_id": 2}
+{"abstract_id": "25248497", "label": "background", "text": "This paper describes the protocol for a cluster randomised controlled trial to test the clinical effectiveness and cost-effectiveness of WWWT when implemented in usual primary care .", "sentence_id": 3}
+{"abstract_id": "25248497", "label": "methods", "text": "@ maternal and child health ( MCH ) centres from six diverse Local Government Areas , in Victoria , Australia are randomly allocated to the intervention group ( usual care plus WWWT ) or the control group ( usual care ) .", "sentence_id": 4}
+{"abstract_id": "25248497", "label": "methods", "text": "The required sample size is @ women in each group .", "sentence_id": 5}
+{"abstract_id": "25248497", "label": "methods", "text": "English-speaking primiparous women receiving postpartum healthcare in participating MCH centres complete two computer-assisted telephone interviews : baseline at @weeks and outcome at @months postpartum .", "sentence_id": 6}
+{"abstract_id": "25248497", "label": "methods", "text": "Women attending intervention MCH centres are invited to attend WWWT in addition to usual care .", "sentence_id": 7}
+{"abstract_id": "25248497", "label": "methods", "text": "The primary outcome is meeting Diagnostic and Statistical Manual-IV ( DSM-IV ) diagnostic criteria for major depressive episode ; generalised anxiety disorder ; panic disorder with or without agoraphobia , agoraphobia with or without panic , social phobia , adult separation anxiety or adjustment disorder with depressed mood , anxiety or mixed depressed mood and anxiety within the past @days at @months postpartum .", "sentence_id": 8}
+{"abstract_id": "25248497", "label": "methods", "text": "Secondary outcomes are self-rated general and emotional health , infant sleep problems , method of infant feeding , quality of mother-infant relationship and intimate partner relationship , and healthcare costs and outcomes .", "sentence_id": 9}
+{"abstract_id": "24300131", "label": "background", "text": "To evaluate the efficacy of the surgical fat-filling procedure ( SFFP ) in the treatment of refractory cough and quality of life ( QOL ) after systematic mediastinal lymphadenectomy in patients with right lung cancer .", "sentence_id": 0}
+{"abstract_id": "24300131", "label": "methods", "text": "This is a blinded , randomized , controlled clinical trial to evaluate refractory cough and QOL in patients after mediastinal lymphadenectomy for lung cancer .", "sentence_id": 1}
+{"abstract_id": "24300131", "label": "methods", "text": "One hundred eligible lung cancer patients were randomly divided into two groups : the fat-filling group and non-filling group .", "sentence_id": 2}
+{"abstract_id": "24300131", "label": "methods", "text": "In the fat-filling group , post-lymphadenectomy residual cavities ( PLRCs ) were filled with fatty tissue autografts after lymph node dissection .", "sentence_id": 3}
+{"abstract_id": "24300131", "label": "methods", "text": "In the non-filling group , the PLRCs remained unfilled .", "sentence_id": 4}
+{"abstract_id": "24300131", "label": "methods", "text": "Clinical endpoints were postoperative cough score and QOL .", "sentence_id": 5}
+{"abstract_id": "24300131", "label": "results", "text": "The SFFP did not increase intraoperative bleeding , extend operation time , or hospital stay .", "sentence_id": 6}
+{"abstract_id": "24300131", "label": "results", "text": "Further , night cough was significantly improved after @wk in the fat-filling group after the removal of a chest drainage tube .", "sentence_id": 7}
+{"abstract_id": "24300131", "label": "results", "text": "QOL issues , such as emotional condition , functional status , and additional concerns , demonstrated a remarkable improvement in the fat-filling group at postoperative @mo compared with the non-filling ( control ) group .", "sentence_id": 8}
+{"abstract_id": "24300131", "label": "conclusions", "text": "This study demonstrates that filling PLRCs with fatty tissue autografts is a safe and partially effective treatment for refractory cough after major pulmonary resection and mediastinal lymphadenectomy .", "sentence_id": 9}
+{"abstract_id": "24300131", "label": "conclusions", "text": "This novel procedure significantly improved patient QOL and may prove useful as a relatively safe preventive surgical adjunct operation for refractory cough .", "sentence_id": 10}
+{"abstract_id": "24337761", "label": "objective", "text": "Modafinil has been reported to benefit a subgroup of patients suffering severe fatigue while undergoing chemotherapy .", "sentence_id": 0}
+{"abstract_id": "24337761", "label": "objective", "text": "Docetaxel is associated with fatigue that may lead to premature therapy withdrawal .", "sentence_id": 1}
+{"abstract_id": "24337761", "label": "objective", "text": "We investigated whether modafinil could reduce fatigue during docetaxel chemotherapy .", "sentence_id": 2}
+{"abstract_id": "24337761", "label": "methods", "text": "This multicenter , randomized , double-blind , placebo-controlled study evaluated the efficacy of modafinil in patients with metastatic prostate or breast cancer undergoing docetaxel chemotherapy ( every @ days ; minimum dose @ mg/m ( @ ) ) .", "sentence_id": 3}
+{"abstract_id": "24337761", "label": "methods", "text": "At the start of their third or subsequent chemotherapy cycle , patients with significant docetaxel-associated fatigue were randomized to receive concurrent modafinil @ mg/day or placebo for @ days ( `` treatment periods '' ( TP ) ) .", "sentence_id": 4}
+{"abstract_id": "24337761", "label": "methods", "text": "Docetaxel was continued for up to four further cycles .", "sentence_id": 5}
+{"abstract_id": "24337761", "label": "methods", "text": "Fatigue was evaluated with the fatigue component of the MD Anderson Symptom Inventory ( MDASI ) .", "sentence_id": 6}
+{"abstract_id": "24337761", "label": "methods", "text": "The primary endpoint was cumulative MDASI area under the curve ( AUC ) during the first @ days of study medication during TP@ and TP@ .", "sentence_id": 7}
+{"abstract_id": "24337761", "label": "results", "text": "Evaluable data were available from @ patients ( @ with prostate cancer ) .", "sentence_id": 8}
+{"abstract_id": "24337761", "label": "results", "text": "There was no statistically significant difference between the two treatment arms for the primary endpoint ( MSADI AUC@-@ @ vs @ ; @ % confidence interval -@ , @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24337761", "label": "results", "text": "Overall toxicity was comparable between treatment groups ; however , the incidence of grade @ nausea and vomiting was higher in the modafinil arm ( @ vs @ % ) .", "sentence_id": 10}
+{"abstract_id": "24337761", "label": "conclusions", "text": "Assessing and managing chemotherapy-related fatigue remains a major challenge .", "sentence_id": 11}
+{"abstract_id": "24337761", "label": "conclusions", "text": "There was a lack of difference between the two arms in the planned primary endpoint .", "sentence_id": 12}
+{"abstract_id": "24337761", "label": "conclusions", "text": "However , there was a modest but consistent trend towards improvement of docetaxel-related fatigue in those treated with modafinil .", "sentence_id": 13}
+{"abstract_id": "24337761", "label": "conclusions", "text": "Based on the study findings , modafinil for the treatment of fatigue associated with docetaxel chemotherapy elicits modest improvements .", "sentence_id": 14}
+{"abstract_id": "24337761", "label": "conclusions", "text": "Larger , longer term , randomized , controlled studies are required to clarify the exact role of modafinil in the treatment of docetaxel-related fatigue .", "sentence_id": 15}
+{"abstract_id": "25275672", "label": "background", "text": "Topiramate ( TOP ) and anticonvulsants in general are considered safe and effective drugs for the treatment of alcohol dependence , even though TOP-induced adverse events are quite common , especially for high initial doses or if titration to @ mg/d is too rapid .", "sentence_id": 0}
+{"abstract_id": "25275672", "label": "background", "text": "The aim of the present study was to assess the efficacy and tolerability profile of low-dose TOP for relapse prevention .", "sentence_id": 1}
+{"abstract_id": "25275672", "label": "methods", "text": "After detoxification , @ patients were randomized into @ groups as follows : @ patients received @ mg of TOP ( oral , twice daily ) , titrated over @ weeks , and @ patients received placebo ( PLA ) .", "sentence_id": 2}
+{"abstract_id": "25275672", "label": "methods", "text": "Both groups underwent rehabilitation twice a week .", "sentence_id": 3}
+{"abstract_id": "25275672", "label": "results", "text": "After @ weeks of treatment , compared with the PLA group , patients receiving TOP showed the following : ( @ ) fewer drinking days ( P < @ ) ; ( @ ) less daily alcohol consumption ( P < @ ) ; ( @ ) more days of treatment ( P < @ ) ; ( @ ) reduced levels of craving ( Obsessive-Compulsive Drinking Scale ) and withdrawal symptoms ( Clinical Institute Withdrawal Assessment for Alcohol-Revised ) ; and ( @ ) improvement of anxiety , depression , and obsessive-compulsive symptom severity ( Symptom Check List @ Revised ) .", "sentence_id": 4}
+{"abstract_id": "25275672", "label": "conclusions", "text": "Despite the small sample size and the short follow-up period , the present PLA-controlled study demonstrated the potential usefulness of TOP , even when administered at a dosage of @ mg/d , for the treatment of detoxified alcohol-dependent subjects , confirming results from previous studies testing higher doses of TOP .", "sentence_id": 5}
+{"abstract_id": "24798104", "label": "background", "text": "Sympathectomy is currently used as the fourth step of the modified World Health Organization ( WHO ) analgesic ladder .", "sentence_id": 0}
+{"abstract_id": "24798104", "label": "background", "text": "Sympathectomy can be performed early , before the second step on the ladder .", "sentence_id": 1}
+{"abstract_id": "24798104", "label": "objective", "text": "We hypothesized that early sympathectomy would reduce pain and opioid consumption and improve quality of life .", "sentence_id": 2}
+{"abstract_id": "24798104", "label": "methods", "text": "One hundred nine patients , with inoperable abdominal or pelvic cancer , reporting visceral pain of @-@ on a visual analogue scale and taking nonopioid analgesics were allocated randomly into two groups : either blocks were performed before Step @ of the WHO ladder , then analgesics were managed according to the ladder ( Group I ) or analgesics were given according to the WHO ladder , and blocks were performed as the fourth step after failure of strong opioids to control pain ( Group II ) .", "sentence_id": 3}
+{"abstract_id": "24798104", "label": "methods", "text": "Visual analogue scale scores , responder analysis , daily opioid consumption , related side effects , and quality of life were assessed .", "sentence_id": 4}
+{"abstract_id": "24798104", "label": "results", "text": "Responders were significantly higher in Group I ( P < @ ) , and partial responders and nonresponders significantly increased in Group II ( P < @ and @ , respectively ) .", "sentence_id": 5}
+{"abstract_id": "24798104", "label": "results", "text": "Opioid consumption significantly decreased in Group I ( P < @ during first @ months and @ at the last assessment time ) , with concomitant significant reduction in related side effects .", "sentence_id": 6}
+{"abstract_id": "24798104", "label": "results", "text": "The number of patients who had a good analgesic response on tramadol significantly increased in Group I during the first five months ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24798104", "label": "results", "text": "European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core @ global quality-of-life subscale scores revealed significant improvement until the fifth month in Group I ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24798104", "label": "conclusions", "text": "Sympathectomy before Step @ on the WHO analgesic ladder seems to lead to better pain control , less opioid consumption , and better quality of life in cancer patients .", "sentence_id": 9}
+{"abstract_id": "24628898", "label": "objective", "text": "To study the effects of oromucosal detomidine gel administered sublingually to calves prior to disbudding , and to compare its efficacy with intravenously ( IV ) administered detomidine .", "sentence_id": 0}
+{"abstract_id": "24628898", "label": "methods", "text": "Randomised , prospective clinical study .", "sentence_id": 1}
+{"abstract_id": "24628898", "label": "methods", "text": "Twenty dairy calves aged @ @ days ( mean SD ) , weight @ @ kg .", "sentence_id": 2}
+{"abstract_id": "24628898", "label": "methods", "text": "Detomidine at @ g kg ( -@ ) was administered to ten calves sublingually ( GEL ) and at @ g kg ( -@ ) to ten control calves IV ( V. jugularis ) .", "sentence_id": 3}
+{"abstract_id": "24628898", "label": "methods", "text": "Meloxicam ( @ mg kg ( -@ ) ) and local anaesthetic ( lidocaine @ mg kg ( -@ ) ) were administered before heat cauterization of horn buds .", "sentence_id": 4}
+{"abstract_id": "24628898", "label": "methods", "text": "Heart rate ( HR ) , body temperature and clinical sedation were monitored over @ minutes .", "sentence_id": 5}
+{"abstract_id": "24628898", "label": "methods", "text": "Blood was collected from the V. cephalica during the same period for drug concentration analysis .", "sentence_id": 6}
+{"abstract_id": "24628898", "label": "methods", "text": "Pharmacokinetic variables were calculated from the plasma detomidine concentration-time data using non-compartmental methods .", "sentence_id": 7}
+{"abstract_id": "24628898", "label": "methods", "text": "Statistical analyses compared routes of administration by Student 's t-test and linear mixed models as relevant .", "sentence_id": 8}
+{"abstract_id": "24628898", "label": "results", "text": "The maximum plasma detomidine concentration after GEL was @ @ ng mL ( -@ ) ( mean SD ) and the time of maximum concentration was @ @ minutes .", "sentence_id": 9}
+{"abstract_id": "24628898", "label": "results", "text": "The bioavailability of detomidine was approximately @ % with GEL .", "sentence_id": 10}
+{"abstract_id": "24628898", "label": "results", "text": "Similar sedation scores were reached in both groups after administration of detomidine , but maximal sedation was reached earlier in the IV group ( @ minutes ) than in the GEL group ( @ minutes ) .", "sentence_id": 11}
+{"abstract_id": "24628898", "label": "results", "text": "HR was lower after IV than GEL from @ to @ minutes after administration .", "sentence_id": 12}
+{"abstract_id": "24628898", "label": "results", "text": "All animals were adequately sedated , and we were able to administer local anaesthetic without resistance to all of the calves before disbudding .", "sentence_id": 13}
+{"abstract_id": "24628898", "label": "conclusions", "text": "Oromucosally administered detomidine is an effective sedative agent for calves prior to disbudding .", "sentence_id": 14}
+{"abstract_id": "25608502", "label": "background", "text": "Several studies have demonstrated that local ischemic preconditioning can reduce myocardial ischemia-reperfusion injury in cardiac surgery patients ; however , preconditioning has not become a standard cardioprotective intervention , primarily because of the increased risk of atheroembolism during repetitive aortic cross-clamping .", "sentence_id": 0}
+{"abstract_id": "25608502", "label": "background", "text": "In the present study , we aimed to describe and validate a novel technique of preconditioning induction .", "sentence_id": 1}
+{"abstract_id": "25608502", "label": "methods", "text": "Patients undergoing coronary artery bypass grafting ( @ women and @ men ; mean age , @years ) were randomized into @ groups : ( @ ) Controls ( n = @ ) , ( @ ) Perfusion ( n = @ ) , and ( @ ) Preconditioning ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25608502", "label": "methods", "text": "All patients were operated under cardiopulmonary bypass using normothermic blood cardioplegia .", "sentence_id": 3}
+{"abstract_id": "25608502", "label": "methods", "text": "Preconditioning was induced by subjecting the hemodynamically unloaded heart to @cycles of @min of ischemia and @min of reperfusion with normokalemic blood prior to cardioplegia .", "sentence_id": 4}
+{"abstract_id": "25608502", "label": "methods", "text": "In the Perfusion group , the heart perfusion remained unaffected for @min .", "sentence_id": 5}
+{"abstract_id": "25608502", "label": "methods", "text": "Troponin I ( TnI ) levels were analyzed before surgery , and @ , @ , @h , and @days after surgery .", "sentence_id": 6}
+{"abstract_id": "25608502", "label": "methods", "text": "The secondary endpoints included the cardiac index , plasma natriuretic peptide level , and postoperative use of inotropes .", "sentence_id": 7}
+{"abstract_id": "25608502", "label": "results", "text": "Preconditioning resulted in a significant reduction in the TnI level on the @th postoperative day only ( @ and @ ng/ml in Preconditioning and Perfusion groups , respectively , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25608502", "label": "results", "text": "In addition , cardiac index was significantly higher in the Preconditioning group than in the Control and Perfusion groups just after weaning from cardiopulmonary bypass .", "sentence_id": 9}
+{"abstract_id": "25608502", "label": "results", "text": "The number of patients requiring inotropic support with@ agents after surgery was significantly lower in the Preconditioning and Perfusion group than in the Control group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25608502", "label": "results", "text": "No complications of the procedure were recorded in the Preconditioning group .", "sentence_id": 11}
+{"abstract_id": "25608502", "label": "conclusions", "text": "The preconditioning procedure described can be performed safely in cardiac surgery patients .", "sentence_id": 12}
+{"abstract_id": "25608502", "label": "conclusions", "text": "The application of this technique of preconditioning was associated with certain benefits , including improved left ventricular function after weaning from cardiopulmonary bypass and a reduced need for inotropic support .", "sentence_id": 13}
+{"abstract_id": "25608502", "label": "conclusions", "text": "However , the infarct-limiting effect of preconditioning in the early postoperative period was not evident .", "sentence_id": 14}
+{"abstract_id": "25608502", "label": "conclusions", "text": "The procedure does not involve repetitive aortic cross-clamping , thus avoiding possible embolic complications .", "sentence_id": 15}
+{"abstract_id": "24920841", "label": "background", "text": "Minimal-change nephrotic syndrome ( MCNS ) is a common cause of steroid sensitive nephrotic syndrome ( NS ) with frequent relapse .", "sentence_id": 0}
+{"abstract_id": "24920841", "label": "background", "text": "Although steroids and calcineurin inhibitors ( CNIs ) are the cornerstone treatments , the use of rituximab ( RTX ) , a monoclonal antibody targeting B cells , is an efficient and safe alternative in childhood .", "sentence_id": 1}
+{"abstract_id": "24920841", "label": "methods", "text": "Because data from adults remain sparse , we conducted a large retrospective and multicentric study that included @ adults with MCNS and receiving RTX .", "sentence_id": 2}
+{"abstract_id": "24920841", "label": "results", "text": "Complete ( NS remission and withdrawal of all immunosuppressants ) and partial ( NS remission and withdrawal of at least one immunosuppressants ) clinical responses were obtained for @ and @ patients , respectively ( overall response @ % ) , including @ patients that only received RTX and had a complete clinical response .", "sentence_id": 3}
+{"abstract_id": "24920841", "label": "results", "text": "After a follow-up time of @ months ( @-@ ) , relapses occurred in @ responder patients -LSB- @ % , median time @ months ( @-@ ) -RSB- .", "sentence_id": 4}
+{"abstract_id": "24920841", "label": "results", "text": "Seventeen of these received a second course of RTX and then had a complete ( n = @ ) or partial ( n = @ ) clinical response .", "sentence_id": 5}
+{"abstract_id": "24920841", "label": "results", "text": "From multivariate analysis , on-going mycophenolate mofetil ( MMF ) therapy at the time of RTX was the only predictive factor for RTX failure -LSB- HR = @ @ % CI ( @-@ @ ) , P = @ -RSB- .", "sentence_id": 6}
+{"abstract_id": "24920841", "label": "results", "text": "Interestingly , nine patients were still in remission at @ months ( @-@ ) after B-cell recovery .", "sentence_id": 7}
+{"abstract_id": "24920841", "label": "results", "text": "No significant early or late adverse event occurred after RTX therapy .", "sentence_id": 8}
+{"abstract_id": "24920841", "label": "conclusions", "text": "RTX is safe and effective in adult patients with MCNS and could be an alternative to steroids or CNIs in patients with a long history of relapsing MCNS .", "sentence_id": 9}
+{"abstract_id": "24240384", "label": "objective", "text": "Extracorporeal circulation ( ECC ) of blood during cardiopulmonary surgery has been shown to stimulate various proinflammatory molecules such as cytokines and chemokines .", "sentence_id": 0}
+{"abstract_id": "24240384", "label": "objective", "text": "The biochemical oxidation/reduction pathways of - lipoic acid suggest that it may have antioxidant properties .", "sentence_id": 1}
+{"abstract_id": "24240384", "label": "methods", "text": "In this study we aimed to evaluate only patients with coronary heart disease and those planned for coronary artery bypass graft operation .", "sentence_id": 2}
+{"abstract_id": "24240384", "label": "methods", "text": "Blood samples were obtained from the patients before the operation ( P@ ) and one ( P@ ) , four ( P@ ) , @ ( P@ ) and @ hours ( P@ ) after administration of - lipoic acid ( LA ) .", "sentence_id": 3}
+{"abstract_id": "24240384", "label": "methods", "text": "The patients were divided into two groups , control and LA treatment group .", "sentence_id": 4}
+{"abstract_id": "24240384", "label": "methods", "text": "Levels of interleukin - @ ( IL-@ ) and -@ ( IL-@ ) , complement @ ( C@ ) and @ ( C@ ) , anti-streptolysin ( ASO ) , C-reactive protein ( CRP ) and haptoglobin were assessed in the blood samples .", "sentence_id": 5}
+{"abstract_id": "24240384", "label": "results", "text": "Cytokine IL-@ and IL-@ levels were significantly higher after surgery .", "sentence_id": 6}
+{"abstract_id": "24240384", "label": "results", "text": "Compared with the control groups , LA significantly decreased IL-@ and IL-@ levels in a time-dependent manner .", "sentence_id": 7}
+{"abstract_id": "24240384", "label": "results", "text": "CRP levels did not show significant variation in the first three time periods .", "sentence_id": 8}
+{"abstract_id": "24240384", "label": "results", "text": "CRP levels were higher after surgery , especially in the later periods .", "sentence_id": 9}
+{"abstract_id": "24240384", "label": "results", "text": "These results demonstrate that CRP formation depends on cytokine release .", "sentence_id": 10}
+{"abstract_id": "24240384", "label": "results", "text": "C@ and C@ levels were significantly higher after surgery than in the pre-operative period .", "sentence_id": 11}
+{"abstract_id": "24240384", "label": "results", "text": "LA treatment decreased C@ and C@ levels .", "sentence_id": 12}
+{"abstract_id": "24240384", "label": "results", "text": "Therefore , LA administration may be useful for the treatment of diseases and processes where excessive cytokine release could cause oxidative damage .", "sentence_id": 13}
+{"abstract_id": "24240384", "label": "conclusions", "text": "Our findings suggest a possible benefit of using LA during cardiac surgery to reduce cytokine levels .", "sentence_id": 14}
+{"abstract_id": "24503408", "label": "objective", "text": "To study the intraocular distribution and safety of polymethylmethacrylate nanoparticles loaded with carboplatin after posterior subtenon injection in humans .", "sentence_id": 0}
+{"abstract_id": "24503408", "label": "methods", "text": "Prospective , interventional , comparative case series .", "sentence_id": 1}
+{"abstract_id": "24503408", "label": "methods", "text": "Six patients ( mean age : @ @ years ) , scheduled to undergo planned uniocular enucleation in aninstitutional setting , were randomly divided into @ groups .", "sentence_id": 2}
+{"abstract_id": "24503408", "label": "methods", "text": "Each group received a @mg/mL posterior subtenon injection of nanoparticle carboplatin in the eye to be enucleated .", "sentence_id": 3}
+{"abstract_id": "24503408", "label": "methods", "text": "Two eyes were enucleated @ , @ and @ hours post injection .", "sentence_id": 4}
+{"abstract_id": "24503408", "label": "methods", "text": "Intravenous blood was collected during enucleation .", "sentence_id": 5}
+{"abstract_id": "24503408", "label": "methods", "text": "The concentration of carboplatin reaching various intraocular tissues was determined by inductively coupled plasma atomic emission spectroscopy .", "sentence_id": 6}
+{"abstract_id": "24503408", "label": "methods", "text": "The drug toxicity in the ocular tissues was assessed by histopathology and high-resolution transmission electron microscopy .", "sentence_id": 7}
+{"abstract_id": "24503408", "label": "results", "text": "The highest level of carboplatin was detected in retinas ( @ @ mg/g ) , up to @ hours post treatment .", "sentence_id": 8}
+{"abstract_id": "24503408", "label": "results", "text": "The intravitreal concentration continued to increase gradually until @ hours ( @ @ mg/g ) .", "sentence_id": 9}
+{"abstract_id": "24503408", "label": "results", "text": "The choroids and lenses showed very low levels of carboplatin after @ hours , with negligible amounts at @ hours .", "sentence_id": 10}
+{"abstract_id": "24503408", "label": "results", "text": "No signs of tissue damage were observed on histopathology or electron microscopy .", "sentence_id": 11}
+{"abstract_id": "24503408", "label": "results", "text": "Intravenous concentration of carboplatin was undetectable in all patients .", "sentence_id": 12}
+{"abstract_id": "24503408", "label": "conclusions", "text": "Results may indicate an increased facilitated trans-scleral transport of nanoparticle carboplatin , with a sustained-release behavior but without any associated short-term ocular or systemic side effects in humans .", "sentence_id": 13}
+{"abstract_id": "24503408", "label": "conclusions", "text": "The very high concentrations achieved in vitreous and retina after a single posterior subtenon injection may be clinically useful for adjunctive treatment of advanced intraocular retinoblastoma with vitreous seeds .", "sentence_id": 14}
+{"abstract_id": "24503408", "label": "conclusions", "text": "However , further studies are needed to assess long-term toxicity andclinical efficacy .", "sentence_id": 15}
+{"abstract_id": "25102193", "label": "background", "text": "Serial wide-field fluorescein angiography was performed on eyes with preproliferative ( ischemic ) central retinal vein occlusion to evaluate retinal perfusion .", "sentence_id": 0}
+{"abstract_id": "25102193", "label": "methods", "text": "Serial wide-field fluorescein angiography was performed on @ preproliferative central retinal vein occlusion eyes in the @-year Rubeosis Anti-VEGF ( RAVE ) trial using the Staurenghi lens ( Ocular Staurenghi @SLO Retina Lens ) with a scanning laser ophthalmoscope ( Heidelberg HRA Spectralis ) .", "sentence_id": 1}
+{"abstract_id": "25102193", "label": "methods", "text": "`` Disk area '' was defined anatomically for each eye .", "sentence_id": 2}
+{"abstract_id": "25102193", "label": "results", "text": "Mean total field of gradable retina was @ disk areas ( range , @-@ ) .", "sentence_id": 3}
+{"abstract_id": "25102193", "label": "results", "text": "All eyes demonstrated extensive areas of retinal nonperfusion ; at baseline , mean area of retinal perfusion was @ disk areas ( range , @-@ ) , correlating with a mean of @ % perfused retinal area ( range , @-@ @ % ) .", "sentence_id": 4}
+{"abstract_id": "25102193", "label": "results", "text": "The area of retinal nonperfusion increased in all eyes with a mean loss of approximately @ % of perfused retinal area per year ( range , @-@ @ % ) , which corresponded to a mean @-disk areas ( range , @-@ ) of retina evolving from perfused to nonperfused annually .", "sentence_id": 5}
+{"abstract_id": "25102193", "label": "results", "text": "The extent of baseline and final nonperfusion was not significantly different between eyes that developed neovascularization and eyes that did not .", "sentence_id": 6}
+{"abstract_id": "25102193", "label": "conclusions", "text": "In this population of severe central retinal vein occlusion eyes , profound retinal nonperfusion was observed with wide-field fluorescein angiography at baseline and the extent of nonperfusion progressed while undergoing anti-vascular endothelial growth factor therapy .", "sentence_id": 7}
+{"abstract_id": "25115430", "label": "objective", "text": "To evaluate effects of preoperative high-dose glucocorticoid on the inflammatory response and recovery after endovascular aortic aneurysm repair ( EVAR ) .", "sentence_id": 0}
+{"abstract_id": "25115430", "label": "background", "text": "The postimplantation syndrome after EVAR may delay recovery due to the release of proinflammatory mediators .", "sentence_id": 1}
+{"abstract_id": "25115430", "label": "background", "text": "Glucocorticoids may reduce postoperative inflammatory responses and enhance recovery , but with limited information on EVAR .", "sentence_id": 2}
+{"abstract_id": "25115430", "label": "methods", "text": "A single-center , randomized , double-blind , placebo-controlled trial of @ patients undergoing elective EVAR between November @ and January @ .", "sentence_id": 3}
+{"abstract_id": "25115430", "label": "methods", "text": "Patients received @ mg/kg of methylprednisolone ( MP ) ( n = @ ) or placebo ( n = @ ) preoperatively .", "sentence_id": 4}
+{"abstract_id": "25115430", "label": "methods", "text": "Primary outcome was a modified version of the systemic inflammatory response syndrome .", "sentence_id": 5}
+{"abstract_id": "25115430", "label": "methods", "text": "Secondary outcome measures were the effect on inflammatory biomarkers , morbidity , and time to meet discharge criteria .", "sentence_id": 6}
+{"abstract_id": "25115430", "label": "results", "text": "Of @ randomized patients , @ ( @ % ) were evaluated for the primary outcome .", "sentence_id": 7}
+{"abstract_id": "25115430", "label": "results", "text": "MP reduced systemic inflammatory response syndrome from @ % to @ % ( P < @ ) ( number needed to treat = @ ) , maximal plasma interleukin @ from @ pg/mL -LSB- interquartile range ( IQR ) = @-@ pg/mL -RSB- to @ pg/mL ( IQR = @-@ pg/mL ) ( P < @ ) and fulfillment of discharge criteria was shorter -LSB- @ days ( IQR = @-@ days ) vs @ days ( IQR = @-@ days ) -RSB- ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25115430", "label": "results", "text": "C-reactive protein , temperature , interleukin @ , and soluble tumor necrosis factor receptor were also reduced ( P < @ ) by MP .", "sentence_id": 9}
+{"abstract_id": "25115430", "label": "results", "text": "Myeloperoxidase , D-dimer , and matrix metalloproteinase @ were not modified .", "sentence_id": 10}
+{"abstract_id": "25115430", "label": "results", "text": "No differences in @-day medical ( @ % vs @ % ) ( P = @ ) or surgical ( @ % vs @ % ) morbidity were found in the active group versus the placebo group .", "sentence_id": 11}
+{"abstract_id": "25115430", "label": "conclusions", "text": "Preoperative MP attenuates the inflammatory response with a faster recovery after EVAR for abdominal aortic aneurysms .", "sentence_id": 12}
+{"abstract_id": "25115430", "label": "conclusions", "text": "Further safety and dose-response studies are required to allow recommendations for general practice .", "sentence_id": 13}
+{"abstract_id": "24335026", "label": "objective", "text": "The present study tested the hypothesis that pretreatment with metformin decreases postprocedural myocardial injury and improves clinical outcomes in metabolic syndrome patients following percutaneous coronary intervention ( PCI ) .", "sentence_id": 0}
+{"abstract_id": "24335026", "label": "methods", "text": "We enrolled @ metabolic syndrome patients with no prior history of metformin treatment .", "sentence_id": 1}
+{"abstract_id": "24335026", "label": "methods", "text": "Patients scheduled for elective coronary intervention were randomized to the metformin or control group @ days before the procedure .", "sentence_id": 2}
+{"abstract_id": "24335026", "label": "methods", "text": "Creatine kinase-MB ( CK-MB ) and troponin I levels were measured at baseline and @ and @ h after the procedure , and clinical outcomes were monitored for @ year .", "sentence_id": 3}
+{"abstract_id": "24335026", "label": "results", "text": "Post-PCI myocardial injury as indicated by CK-MB elevation ( @ vs. @ % , p = @ ) and troponin I elevation ( @ vs. @ % , p = @ ) was significantly lower in the metformin group than in the control group .", "sentence_id": 4}
+{"abstract_id": "24335026", "label": "results", "text": "Postprocedural peak values of CK-MB ( @ @ vs. @ @ ng/ml , p < @ ) and troponin I ( @ @ vs. @ @ ng/ml , p = @ ) were also significantly lower in the metformin group than in the control group .", "sentence_id": 5}
+{"abstract_id": "24335026", "label": "results", "text": "At @ year , the composite endpoint of death from any cause , post-PCI myocardial infarction ( MI ) , MI after PCI hospitalization or ischemia-driven target lesion revascularization occurred in @ % of metformin-treated patients and @ % of controls ( hazard ratio @ , @ % CI @-@ @ , log rank p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24335026", "label": "conclusions", "text": "A @-day metformin pretreatment regimen ( @ mg @ times a day ) significantly reduces postprocedural myocardial injury and improves @-year clinical outcomes in metabolic syndrome patients undergoing PCI .", "sentence_id": 7}
+{"abstract_id": "24720396", "label": "objective", "text": "To evaluate tooth position after six and @ months of orthodontics with conventional brackets on one side of the dentition and ligature-less brackets on the other .", "sentence_id": 0}
+{"abstract_id": "24720396", "label": "methods", "text": "Orthodontic Division , Vienna Medical University .", "sentence_id": 1}
+{"abstract_id": "24720396", "label": "methods", "text": "Twenty patients aged @ @ years , symmetrical malocclusion and arch form , no premolar extraction .", "sentence_id": 2}
+{"abstract_id": "24720396", "label": "methods", "text": "Prospective split-mouth study , @-inch SmartClip self-ligating brackets assigned randomly to the left or right dentition , conventional @-inch brackets on the other side .", "sentence_id": 3}
+{"abstract_id": "24720396", "label": "methods", "text": "@ dental landmarks , digitized on plaster casts , represented dental arches at baseline ( t@ ) , @ months and @ months ( t@ , t@ ) .", "sentence_id": 4}
+{"abstract_id": "24720396", "label": "methods", "text": "During t@-t@ , we used @ and @ x @ inch superelastic wires , during t@-t@ connected reverse-curve hemiarch wires : @ x @ inch - titanium on the ligature-less side , and @ x @ inch Elgiloy multiloop wires on conventional brackets .", "sentence_id": 5}
+{"abstract_id": "24720396", "label": "methods", "text": "Morphometric analyses were used to assess differences in dental arch shapes .", "sentence_id": 6}
+{"abstract_id": "24720396", "label": "results", "text": "Neither initial alignment nor the reverse-curve phase showed statistically significant differences between ligature-less and conventional brackets in moving teeth .", "sentence_id": 7}
+{"abstract_id": "24720396", "label": "conclusions", "text": "Morphometric shape analyses corroborated current evidence that self-ligating brackets were no more effective than conventional brackets with steel ligatures after @-month initial alignment .", "sentence_id": 8}
+{"abstract_id": "24720396", "label": "conclusions", "text": "From months @-@ treatment with - titanium reverse-curve wires on @-inch ligature-less brackets resulted in similar tooth positions as accomplished by Elgiloy multiloop wires on @-inch steel-ligature-tied brackets .", "sentence_id": 9}
+{"abstract_id": "24650832", "label": "objective", "text": "To examine the effect of cognitive-behavioral therapy for insomnia ( CBTI ) on sleep improvement , daytime symptoms , and quality of life ( QOL ) in breast cancer survivors ( BCSs ) after cancer treatment .", "sentence_id": 0}
+{"abstract_id": "24650832", "label": "methods", "text": "A prospective , longitudinal , randomized , controlled trial .", "sentence_id": 1}
+{"abstract_id": "24650832", "label": "methods", "text": "Oncology clinics , breast cancer support groups , and communities in Colorado .", "sentence_id": 2}
+{"abstract_id": "24650832", "label": "methods", "text": "@ middle-aged BCSs with chronic insomnia .", "sentence_id": 3}
+{"abstract_id": "24650832", "label": "methods", "text": "Women were randomly assigned to CBTI or behavioral placebo treatment ( BPT ) and completed measures of sleep , QOL , functioning , fatigue , and mood at baseline , postintervention , and at three - and six-month follow-ups .", "sentence_id": 4}
+{"abstract_id": "24650832", "label": "methods", "text": "Sleep outcomes ( e.g. , sleep efficiency , sleep latency , total sleep time , wake after sleep onset , number of nightly awakenings ) ; secondary variables included sleep medication use , insomnia severity , QOL , physical function , cognitive function , fatigue , depression , anxiety , and sleep attitudes or knowledge .", "sentence_id": 5}
+{"abstract_id": "24650832", "label": "results", "text": "Sleep efficiency and latency improved more in the CBTI group than the BPT group ; this difference was maintained during follow-up .", "sentence_id": 6}
+{"abstract_id": "24650832", "label": "results", "text": "Women in the CBTI group had less subjective insomnia , greater improvements in physical and cognitive functioning , positive sleep attitudes , and increased sleep hygiene knowledge .", "sentence_id": 7}
+{"abstract_id": "24650832", "label": "results", "text": "No group differences in improvement were noted relative to QOL , fatigue , or mood .", "sentence_id": 8}
+{"abstract_id": "24650832", "label": "conclusions", "text": "Nurse-delivered CBTI appears to be beneficial for BCSs ' sleep latency/efficiency , insomnia severity , functioning , sleep knowledge , and attitudes more than active placebo , with sustained benefit over time .", "sentence_id": 9}
+{"abstract_id": "24650832", "label": "conclusions", "text": "Oncology nurses are in a unique position to identify insomnia in cancer survivors .", "sentence_id": 10}
+{"abstract_id": "24650832", "label": "conclusions", "text": "When sleep disturbances become chronic , nurses need to make recommendations and referrals .", "sentence_id": 11}
+{"abstract_id": "24432677", "label": "objective", "text": "To observe changes of brain glucose metabolism by needling at Waiguan ( SJ@ ) in cerebral infraction ( CI ) patients using @F-fluorodeoxyglucose ( FDG ) positron-emission computer tomography ( PET/CT ) , thus exploring its effect and mechanisms .", "sentence_id": 0}
+{"abstract_id": "24432677", "label": "methods", "text": "A total of @ patients with CI were recruited in this study .", "sentence_id": 1}
+{"abstract_id": "24432677", "label": "methods", "text": "The location of lesion was limited to the left basal ganglia by CT or MRI scan .", "sentence_id": 2}
+{"abstract_id": "24432677", "label": "methods", "text": "All patients were randomly assigned to three groups .", "sentence_id": 3}
+{"abstract_id": "24432677", "label": "methods", "text": "i.e. , the acupoint group ( Group A ) , the non-acupoint group ( Group B ) , the blank control group ( Group C ) , @ in each group .", "sentence_id": 4}
+{"abstract_id": "24432677", "label": "methods", "text": "Patients in Group A were needled at right Waiguan ( SJ@ ) .", "sentence_id": 5}
+{"abstract_id": "24432677", "label": "methods", "text": "Those in Group B were needled at non-acupoint -LSB- @ mm beside Waiguan ( SJ@ ) -RSB- , whereas those in Group C did not receive any treatment .", "sentence_id": 6}
+{"abstract_id": "24432677", "label": "methods", "text": "All patients underwent PET/CT head scan .", "sentence_id": 7}
+{"abstract_id": "24432677", "label": "methods", "text": "All data were statistically analyzed using SPSS @ Software and SPM@ Software .", "sentence_id": 8}
+{"abstract_id": "24432677", "label": "results", "text": "Compared with Group C , glucose metabolism increased in bilateral superior temporal gyrus ( BA@ ) , right superior frontal gyrus ( BA@ ) , left cingulate gyrus ( BA@ ) , left culmen and pyramid of cerebellum , and right cerebellar tonsil of cerebellum in Group A. Compared with Group C , glucose metabolism increased in bilateral superior frontal gyrus ( BA@ , BA@ , BA@ ) , bilateral middle frontal gyrus ( BA@ , BA@ ) , left middle frontal gyrus ( BA@ ) , bilateral uncus of limbic lobe ( BA@ , BA@ ) , left cingulate gyrus ( BA@ , BA@ ) , left posterior cingulate gyrus ( BA@ ) , left precuneus ( BA@ ) , left inferior parietal lobule ( BA@ ) , and left lingual gyrus of occipital lobe ( BA@ ) in Group B. Compared with Group B , glucose metabolism increased in bilateral superior temporal gyrus ( BA@ , BA@ ) , right inferior frontal gyrus ( BA@ ) , left culmen and cerebellar tonsil of cerebellum in Group A. Activated encephalic regions of needling at Waiguan ( SJ@ ) were mainly dominated in the healthy side , bilateral superior temporal gyrus , and right inferior frontal gyrus .", "sentence_id": 9}
+{"abstract_id": "24432677", "label": "results", "text": "Activated encephalic regions of cerebellum were located at the left cerebellar hemisphere , left culmen of anterior cerebella lobe , and bilateral cerebellar tonsil of posterior cerebella lobe .", "sentence_id": 10}
+{"abstract_id": "24432677", "label": "conclusions", "text": "Needling at Waiguan ( SJ@ ) of CI patients induced increased glucose metabolism in local cerebral regions .", "sentence_id": 11}
+{"abstract_id": "24432677", "label": "conclusions", "text": "Functional neuroimaging using PET/CT could directly reflect changes of brain glucose metabolism by acupuncture .", "sentence_id": 12}
+{"abstract_id": "24409833", "label": "background", "text": "Asians are prone to develop epidermal pigmentary lesions as a result of photoaging .", "sentence_id": 0}
+{"abstract_id": "24409833", "label": "background", "text": "Solar lentigines , especially those which are light in color , show somewhat limited response to pigment lasers and intense pulsed light sources .", "sentence_id": 1}
+{"abstract_id": "24409833", "label": "objective", "text": "We sought to compare the early effects as well as side effects of Q-switched Nd : YAG and Er : YAG micropeel in treating light solar lentigines in Asians .", "sentence_id": 2}
+{"abstract_id": "24409833", "label": "methods", "text": "This was a split-face , evaluator-blind , randomized controlled study .", "sentence_id": 3}
+{"abstract_id": "24409833", "label": "methods", "text": "A single session of treatment was performed on Asian patients with light facial lentigines .", "sentence_id": 4}
+{"abstract_id": "24409833", "label": "methods", "text": "Q-switched Nd : YAG laser was allocated to one half of the face , and Er : YAG micropeel to the other half .", "sentence_id": 5}
+{"abstract_id": "24409833", "label": "methods", "text": "The response to therapy was evaluated by two independent dermatologists with standardized photographs taken @ weeks and @ month after the laser treatment .", "sentence_id": 6}
+{"abstract_id": "24409833", "label": "methods", "text": "Patients ' satisfaction and preference in treatment were also assessed .", "sentence_id": 7}
+{"abstract_id": "24409833", "label": "results", "text": "Fifteen patients completed the study and were analyzed .", "sentence_id": 8}
+{"abstract_id": "24409833", "label": "results", "text": "A reduction in pigment was observed with both lasers during the study period .", "sentence_id": 9}
+{"abstract_id": "24409833", "label": "results", "text": "The degree of pigment reduction in the Q-switched Nd : YAG treated side of the face was significantly higher than that of the Er : YAG micropeel treated side at @-week follow-up ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24409833", "label": "results", "text": "The degree of pigment reduction between the Q-switched Nd : YAG-treated side and the Er : YAG micropeel-treated side was similar at @-month follow-up ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24409833", "label": "conclusions", "text": "While there is no perfect therapy for light solar lentigines , a single session of Q-switched Nd : YAG laser and Er : YAG micropeel was shown to reduce pigmentation .", "sentence_id": 12}
+{"abstract_id": "24409833", "label": "conclusions", "text": "The immediate effects ( @-week follow-up ) were better with the Q-switched Nd : YAG laser but there was no great difference between the two laser types at @-month follow-up due to the greater degree of post-inflammatory hyperpigmentation following Q-switched Nd : YAG .", "sentence_id": 13}
+{"abstract_id": "24409833", "label": "conclusions", "text": "Both laser types could be applied either singly in turns , or in combination for maximal efficacy in future .", "sentence_id": 14}
+{"abstract_id": "25212703", "label": "objective", "text": "Daclizumab is a humanized monoclonal antibody that blocks the - subunit of the interleukin-@ receptor with demonstrated benefits in the treatment of multiple sclerosis .", "sentence_id": 0}
+{"abstract_id": "25212703", "label": "objective", "text": "The present work aimed to characterize the pharmacokinetics of daclizumab high-yield process ( HYP ) in healthy volunteers .", "sentence_id": 1}
+{"abstract_id": "25212703", "label": "methods", "text": "Three double-blind , randomized , placebo-controlled , phaseI studies evaluated the pharmacokinetics of daclizumab HYP in healthy volunteers following single subcutaneous administration ( @ , @ , or @mg ) , multiple subcutaneous administrations ( @ or @mg biweekly with a @mg loading dose ) , or single intravenous administration ( @ or @mg ) .", "sentence_id": 2}
+{"abstract_id": "25212703", "label": "methods", "text": "Measurable serum concentrations ( n = @ ) from @ subjects treated with daclizumab HYP in the three studies were analyzed using non-linear mixed-effects modeling .", "sentence_id": 3}
+{"abstract_id": "25212703", "label": "results", "text": "A two-compartment model with a first-order absorption and elimination adequately described daclizumab HYP pharmacokinetics .", "sentence_id": 4}
+{"abstract_id": "25212703", "label": "results", "text": "Daclizumab HYP clearance , inter-compartmental clearance , and central and peripheral volumes of distribution were @mL/h , @mL/h , @ L , and @ L , respectively , scaled by -LSB- bodyweight ( kg ) / @ -RSB- with @ and @ exponents for clearance and volume parameters , respectively .", "sentence_id": 5}
+{"abstract_id": "25212703", "label": "results", "text": "Lag-time , mean absorption time , and absolute bioavailability ( @-@mg ) for subcutaneous administration were @h , @ days , and @ % , respectively .", "sentence_id": 6}
+{"abstract_id": "25212703", "label": "results", "text": "Bodyweight explained only ~ @ % of daclizumab HYP pharmacokinetic variability .", "sentence_id": 7}
+{"abstract_id": "25212703", "label": "results", "text": "With this limited dataset , sex , age , race , or presence of antibodies did not correlate with daclizumab HYP clearance .", "sentence_id": 8}
+{"abstract_id": "25212703", "label": "results", "text": "The estimated effective half-life was @-@days .", "sentence_id": 9}
+{"abstract_id": "25212703", "label": "results", "text": "The developed model was robust in bootstrap evaluation and predicted the data adequately in stochastic simulations .", "sentence_id": 10}
+{"abstract_id": "25212703", "label": "conclusions", "text": "Daclizumab HYP is characterized by slow clearance , linear pharmacokinetics ( at doses@mg ) , high subcutaneous bioavailability , and a half-life suitable for monthly administration .", "sentence_id": 11}
+{"abstract_id": "24635770", "label": "background", "text": "The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least @ mm Hg during initial resuscitation of patients with septic shock .", "sentence_id": 0}
+{"abstract_id": "24635770", "label": "background", "text": "However , whether this blood-pressure target is more or less effective than a higher target is unknown .", "sentence_id": 1}
+{"abstract_id": "24635770", "label": "methods", "text": "In a multicenter , open-label trial , we randomly assigned @ patients with septic shock to undergo resuscitation with a mean arterial pressure target of either @ to @ mm Hg ( high-target group ) or @ to @ mm Hg ( low-target group ) .", "sentence_id": 2}
+{"abstract_id": "24635770", "label": "methods", "text": "The primary end point was mortality at day @ .", "sentence_id": 3}
+{"abstract_id": "24635770", "label": "results", "text": "At @ days , there was no significant between-group difference in mortality , with deaths reported in @ of @ patients in the high-target group ( @ % ) and @ of @ patients in the low-target group ( @ % ) ( hazard ratio in the high-target group , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24635770", "label": "results", "text": "There was also no significant difference in mortality at @ days , with @ deaths ( @ % ) and @ deaths ( @ % ) , respectively ( hazard ratio , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24635770", "label": "results", "text": "The occurrence of serious adverse events did not differ significantly between the two groups ( @ events -LSB- @ % -RSB- and @ events -LSB- @ % -RSB- , respectively ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24635770", "label": "results", "text": "However , the incidence of newly diagnosed atrial fibrillation was higher in the high-target group than in the low-target group .", "sentence_id": 7}
+{"abstract_id": "24635770", "label": "results", "text": "Among patients with chronic hypertension , those in the high-target group required less renal-replacement therapy than did those in the low-target group , but such therapy was not associated with a difference in mortality .", "sentence_id": 8}
+{"abstract_id": "24635770", "label": "conclusions", "text": "Targeting a mean arterial pressure of @ to @ mm Hg , as compared with @ to @ mm Hg , in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either @ or @ days .", "sentence_id": 9}
+{"abstract_id": "24635770", "label": "conclusions", "text": "( Funded by the French Ministry of Health ; SEPSISPAM ClinicalTrials.gov number , NCT@ . )", "sentence_id": 10}
+{"abstract_id": "24937907", "label": "objective", "text": "The main aim of the study was to evaluate the effect on subjects ' temperature measurement readings when using the infrared tympanic thermometer after correct earphone placement and use , with or without music transmission through the earphone .", "sentence_id": 0}
+{"abstract_id": "24937907", "label": "methods", "text": "A comparative study design was adopted .", "sentence_id": 1}
+{"abstract_id": "24937907", "label": "methods", "text": "A sample of @ healthy people was randomly divided into three groups .", "sentence_id": 2}
+{"abstract_id": "24937907", "label": "methods", "text": "Subjects in all groups used an earphone that had been correctly placed in the right ear only : Group @ : listened to heavy metal music through the earphone ( @ participants ) ; Group @ : listened to classical music through the earphone ( @ participants ) ; Group @ : no music or sound was transmitted through the earphone ( @ participants ) .", "sentence_id": 3}
+{"abstract_id": "24937907", "label": "methods", "text": "Average differences ( CI @ % ) and Pearson correlations for the temperature measured in the right ear , which was exposed to the different independent variables , and the left ear which was not exposed , were calculated at different times : ( @ ) after @ minutes compared to the baseline measurement ; ( @ ) after @ minutes compared to the @ minutes measurement ; and ( @ ) after @ minutes compared to the baseline measurement .", "sentence_id": 4}
+{"abstract_id": "24937907", "label": "results", "text": "The inter-ear temperature correlation at the baseline was Pearson r @ ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24937907", "label": "results", "text": "There was a significant decrease in the correlations between right and left ear temperatures in Group @ and in Group @ which was demonstrated after @ minutes of earphone use , and reached critical values after @ minutes of use in all groups .", "sentence_id": 6}
+{"abstract_id": "24937907", "label": "results", "text": "The average warmth in the right ear , as perceived by participants after @ minutes , was reported .", "sentence_id": 7}
+{"abstract_id": "24937907", "label": "results", "text": "Using the Numerical Rating Score the average was @ + / - @ for Group @ , for Group @ was @ + / - @ and for Group @ was @ + / - @ ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24937907", "label": "conclusions", "text": "Within the limitations of the study , which involved a limited number of healthy people the results show that it is best to not measure tympanic temperature in an ear that has very recently had an earphone in place .", "sentence_id": 9}
+{"abstract_id": "26171933", "label": "background", "text": "The aim of this study was to assess the efficacy of neoadjuvant anastrozole and fulvestrant treatment of large operable or locally advanced hormone-receptor-positive breast cancer not eligible for initial breast-conserving surgery , and to identify genomic changes occurring after treatment .", "sentence_id": 0}
+{"abstract_id": "26171933", "label": "methods", "text": "One hundred and twenty post-menopausal patients were randomised to receive @mg anastrozole ( @ patients ) or @mg fulvestrant ( @ patients ) for @ months .", "sentence_id": 1}
+{"abstract_id": "26171933", "label": "methods", "text": "Genomic DNA copy number profiles were generated for a subgroup of @ patients before and after treatment .", "sentence_id": 2}
+{"abstract_id": "26171933", "label": "results", "text": "A total of @ patients were evaluable for efficacy and @ for toxicity .", "sentence_id": 3}
+{"abstract_id": "26171933", "label": "results", "text": "The objective response rate determined by clinical palpation was @ % ( @ % CI = @-@ @ ) in the anastrozole arm and @ % ( @ % CI = @-@ @ ) in the fulvestrant arm .", "sentence_id": 4}
+{"abstract_id": "26171933", "label": "results", "text": "The breast-conserving surgery rate was @ % ( @ % CI = @-@ @ ) in the anastrozole arm and @ % ( @ % CI = @-@ @ ) in the fulvestrant arm .", "sentence_id": 5}
+{"abstract_id": "26171933", "label": "results", "text": "Pathological responses > @ % occurred in @ patients ( @ % ) in the anastrozole arm and @ ( @ % ) in the fulvestrant arm .", "sentence_id": 6}
+{"abstract_id": "26171933", "label": "results", "text": "The Ki-@ score fell after treatment but there was no significant difference between the reduction in the two arms ( anastrozole @ % ( @ % CI = @-@ @ ) before , @ % ( @ % CI = @-@ @ ) after , n = @ ; fulvestrant @ % ( @ % CI = @-@ @ ) before , @ % ( @ % CI = @-@ @ ) after , n = @ ) or between the reduction in Ki-@ in clinical responders and non-responders .", "sentence_id": 7}
+{"abstract_id": "26171933", "label": "results", "text": "Genomic analysis appeared to show a reduction of clonal diversity following treatment with selection of some clones with simpler copy number profiles .", "sentence_id": 8}
+{"abstract_id": "26171933", "label": "conclusions", "text": "Both anastrozole and fulvestrant were effective and well-tolerated , enabling breast-conserving surgery in over @ % of patients .", "sentence_id": 9}
+{"abstract_id": "26171933", "label": "conclusions", "text": "Clonal changes consistent with clonal selection by the treatment were seen in a subgroup of patients .", "sentence_id": 10}
+{"abstract_id": "25200170", "label": "background", "text": "The purpose of the present study is to evaluate the impact of a health psychology-led bariatric rehabilitation service ( BRS ) on patient weight loss following bariatric surgery at @ year .", "sentence_id": 0}
+{"abstract_id": "25200170", "label": "methods", "text": "A single-site open-randomised parallel group control trial based at St. Richard 's Hospital in Chichester in the UK .", "sentence_id": 1}
+{"abstract_id": "25200170", "label": "methods", "text": "Patients ( n = @ ) were recruited immediately prior to Roux-en-Y gastric bypass and randomly allocated to receive either treatment as usual ( n = @ ) or the BRS ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25200170", "label": "methods", "text": "The BRS involved three @-min one-to-one sessions with a health psychologist and provided information , support and mentoring pre and post surgery addressing psychological issues such as dietary control , self esteem , coping and emotional eating .", "sentence_id": 3}
+{"abstract_id": "25200170", "label": "methods", "text": "Weight loss was assessed at @ year .", "sentence_id": 4}
+{"abstract_id": "25200170", "label": "methods", "text": "The key outcome variable was BMI and change in BMI .", "sentence_id": 5}
+{"abstract_id": "25200170", "label": "results", "text": "Follow-up weight was available for @ patients .", "sentence_id": 6}
+{"abstract_id": "25200170", "label": "results", "text": "Intention-to-treat analysis ( n = @ ) using last measured weights showed that mean change in BMI by @ year post surgery was -@ .", "sentence_id": 7}
+{"abstract_id": "25200170", "label": "results", "text": "There was no significant difference between the two groups ( control group = -@ , @ % CI = @-@ @ ; intervention = -@ , @ % CI = @-@ @ ; p ( @ ) = @ ) .", "sentence_id": 8}
+{"abstract_id": "25200170", "label": "results", "text": "Similarly , explanatory analysis ( n = @ ) showed a mean change in BMI of -@ .", "sentence_id": 9}
+{"abstract_id": "25200170", "label": "results", "text": "The difference between the two groups was not significant ( control group = -@ , @ % CI = @-@ @ ; intervention = -@ , @ % CI = @-@ @ ; p ( @ ) = @ ) .", "sentence_id": 10}
+{"abstract_id": "25200170", "label": "conclusions", "text": "Psychological support pre and post bariatric surgery had no impact on weight loss as measured by BMI and change in BMI by @ year .", "sentence_id": 11}
+{"abstract_id": "25200170", "label": "conclusions", "text": "It is argued that psychological support should be targeted to patients who start to demonstrate weight regain at a later stage .", "sentence_id": 12}
+{"abstract_id": "24257456", "label": "background", "text": "The Orsiro Hybrid sirolimus-eluting stent is a newly developed third-generation drug-eluting stent , featuring a unique dual-polymer mix .", "sentence_id": 0}
+{"abstract_id": "24257456", "label": "background", "text": "An active bioabsorbable polymer delivers the anti-proliferative drug , sirolimus , via controlled release , while a passive biocompatible polymeric coating shields the metallic strut from surrounding tissue , preventing interaction .", "sentence_id": 1}
+{"abstract_id": "24257456", "label": "background", "text": "To date , the Orsiro Hybrid sirolimus-eluting stent has excelled in terms of late lumen loss at @ months in a first-in-man single-arm trial .", "sentence_id": 2}
+{"abstract_id": "24257456", "label": "background", "text": "However , the efficacy and safety data for Orsiro Hybrid sirolimus-eluting stents in a broader population of all-comers are limited .", "sentence_id": 3}
+{"abstract_id": "24257456", "label": "background", "text": "The present study offers an angiographic and clinical comparison of the Orsiro Hybrid sirolimus-eluting stent and the Resolute Integrity zotarolimus-eluting stent in the treatment of patients with coronary artery disease .", "sentence_id": 4}
+{"abstract_id": "24257456", "label": "methods", "text": "The ORIENT trial is a multicenter , randomized , open-label , parallel-arm study designed to demonstrate the non-inferiority of the Orsiro Hybrid sirolimus-eluting stent relative to the Resolute Integrity zotarolimus-eluting stent .", "sentence_id": 5}
+{"abstract_id": "24257456", "label": "methods", "text": "A total of @ patients with a spectrum of coronary artery disease will undergo prospective , random assignment to a Orsiro Hybrid sirolimus-eluting stent or Resolute Integrity zotarolimus-eluting stent ( @:@ ratio ) , for a primary endpoint of in-stent late lumen loss at @ months by quantitative coronary angiography .", "sentence_id": 6}
+{"abstract_id": "24257456", "label": "methods", "text": "Secondary @-month clinical endpoints are death , target lesion revascularization , target vessel revascularization , myocardial infarction , stent thrombosis and target lesion failure ( a composite of cardiac death , target lesion revascularization and target vessel-related myocardial infarction ) .", "sentence_id": 7}
+{"abstract_id": "24257456", "label": "conclusions", "text": "The ORIENT trial is the first study to date comparing the Orsiro Hybrid sirolimus-eluting stent with the Resolute Integrity zotarolimus-eluting stent for efficacy and safety in a population of all-comers with coronary artery disease .", "sentence_id": 8}
+{"abstract_id": "25908066", "label": "background", "text": "Patients receiving oral anticoagulation ( OAC ) who undergo drug-eluting stent ( DES ) implantation require additional dual antiplatelet therapy with aspirin and clopidogrel .", "sentence_id": 0}
+{"abstract_id": "25908066", "label": "background", "text": "Such triple therapy confers an elevated bleeding risk , and its optimal duration is not known .", "sentence_id": 1}
+{"abstract_id": "25908066", "label": "objective", "text": "The goal of this study was to evaluate whether shortening the duration of clopidogrel therapy from @ months to @ weeks after DES implantation was associated with a superior net clinical outcome in patients receiving concomitant aspirin and OAC .", "sentence_id": 2}
+{"abstract_id": "25908066", "label": "methods", "text": "In this randomized , open-label trial , we enrolled patients receiving OAC who underwent DES implantation at @ European centers between September @ and December @ .", "sentence_id": 3}
+{"abstract_id": "25908066", "label": "methods", "text": "A total of @ patients receiving concomitant aspirin and OAC were randomized to either @-week clopidogrel therapy ( n = @ ) or @-month clopidogrel therapy ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25908066", "label": "methods", "text": "The primary endpoint was a composite of death , myocardial infarction ( MI ) , definite stent thrombosis , stroke , or Thrombolysis In Myocardial Infarction ( TIMI ) major bleeding at @ months .", "sentence_id": 5}
+{"abstract_id": "25908066", "label": "results", "text": "The primary endpoint occurred in @ patients ( @ % ) in the @-week group compared with @ patients ( @ % ) in the @-month group ( hazard ratio -LSB- HR -RSB- : @ ; @ % CI : @ to @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25908066", "label": "results", "text": "There were no significant differences for the secondary combined ischemic endpoint of cardiac death , MI , definite stent thrombosis , and ischemic stroke ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ; HR : @ ; @ % CI : @ to @ ; p = @ ) or the secondary bleeding endpoint of TIMI major bleeding ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ; HR : @ ; @ % CI : @ to @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25908066", "label": "conclusions", "text": "Six weeks of triple therapy was not superior to @ months with respect to net clinical outcomes .", "sentence_id": 8}
+{"abstract_id": "25908066", "label": "conclusions", "text": "These results suggest that physicians should weigh the trade-off between ischemic and bleeding risk when choosing the shorter or longer duration of triple therapy .", "sentence_id": 9}
+{"abstract_id": "25908066", "label": "conclusions", "text": "( Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation -LSB- ISAR-TRIPLE -RSB- ; NCT@ ) .", "sentence_id": 10}
+{"abstract_id": "26039600", "label": "background", "text": "The Veterans Affairs Diabetes Trial previously showed that intensive glucose lowering , as compared with standard therapy , did not significantly reduce the rate of major cardiovascular events among @ military veterans ( median follow-up , @ years ) .", "sentence_id": 0}
+{"abstract_id": "26039600", "label": "background", "text": "We report the extended follow-up of the study participants .", "sentence_id": 1}
+{"abstract_id": "26039600", "label": "methods", "text": "After the conclusion of the clinical trial , we followed participants , using central databases to identify procedures , hospitalizations , and deaths ( complete cohort , with follow-up data for @ % of participants ) .", "sentence_id": 2}
+{"abstract_id": "26039600", "label": "methods", "text": "Most participants agreed to additional data collection by means of annual surveys and periodic chart reviews ( survey cohort , with @ % follow-up ) .", "sentence_id": 3}
+{"abstract_id": "26039600", "label": "methods", "text": "The primary outcome was the time to the first major cardiovascular event ( heart attack , stroke , new or worsening congestive heart failure , amputation for ischemic gangrene , or cardiovascular-related death ) .", "sentence_id": 4}
+{"abstract_id": "26039600", "label": "methods", "text": "Secondary outcomes were cardiovascular mortality and all-cause mortality .", "sentence_id": 5}
+{"abstract_id": "26039600", "label": "results", "text": "The difference in glycated hemoglobin levels between the intensive-therapy group and the standard-therapy group averaged @ percentage points during the trial ( median level , @ % vs. @ % ) and declined to @ to @ percentage points by @ years after the trial ended .", "sentence_id": 6}
+{"abstract_id": "26039600", "label": "results", "text": "Over a median follow-up of @ years , the intensive-therapy group had a significantly lower risk of the primary outcome than did the standard-therapy group ( hazard ratio , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) , with an absolute reduction in risk of @ major cardiovascular events per @ person-years , but did not have reduced cardiovascular mortality ( hazard ratio , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26039600", "label": "results", "text": "No reduction in total mortality was evident ( hazard ratio in the intensive-therapy group , @ ; @ % CI , @ to @ ; P = @ ; median follow-up , @ years ) .", "sentence_id": 8}
+{"abstract_id": "26039600", "label": "conclusions", "text": "After nearly @ years of follow-up , patients with type @ diabetes who had been randomly assigned to intensive glucose control for @ years had @ fewer major cardiovascular events per @ person-years than those assigned to standard therapy , but no improvement was seen in the rate of overall survival .", "sentence_id": 9}
+{"abstract_id": "26039600", "label": "conclusions", "text": "( Funded by the VA Cooperative Studies Program and others ; VADT ClinicalTrials.gov number , NCT@ . )", "sentence_id": 10}
+{"abstract_id": "25221851", "label": "objective", "text": "To determine inter - and intra-tester reliability of strength measurements during maximal electrically induced contractions ( MEIC ) using a hand-held dynamometer ( HHD ) .", "sentence_id": 0}
+{"abstract_id": "25221851", "label": "methods", "text": "Thirty-seven healthy young female adults , mean age ( SD ) @ ( @ ) years , were tested by two examiners during two sessions , with order of examiners randomized .", "sentence_id": 1}
+{"abstract_id": "25221851", "label": "methods", "text": "Biphasic pulses ( phase duration -- @s ; pulse frequency -- @Hz ) were employed in order to induce contractions of the quadriceps femoris muscle at a maximally tolerated current level .", "sentence_id": 2}
+{"abstract_id": "25221851", "label": "methods", "text": "Strength of maximal voluntary isometric contractions ( MVIC ) and of MEIC was recorded with a HHD utilizing a stabilization belt .", "sentence_id": 3}
+{"abstract_id": "25221851", "label": "results", "text": "Good to excellent inter - and intra-tester reliability were determined with intra-class correlation coefficients ranging between @ and @ , and no bias in the Bland-Altman plots .", "sentence_id": 4}
+{"abstract_id": "25221851", "label": "results", "text": "The @ % repeatability ranged between @ and @ kg for the MVIC and MEIC , and between @ and @ % for the % MVIC .", "sentence_id": 5}
+{"abstract_id": "25221851", "label": "conclusions", "text": "Our results confirm previous findings indicating good to excellent reliability of quadriceps femoris muscle MVIC assessment with a HHD .", "sentence_id": 6}
+{"abstract_id": "25221851", "label": "conclusions", "text": "However , a high @ % repeatability range indicates the HHD is not sufficiently reliable as an indicator of the force level attained during electrically induced contractions .", "sentence_id": 7}
+{"abstract_id": "25221851", "label": "conclusions", "text": "Other methods need to be investigated to assist in determining whether MEIC have reached therapeutic levels .", "sentence_id": 8}
+{"abstract_id": "24225740", "label": "objective", "text": "To compare the effects of a @-week supplementation between two different mixtures of antioxidants and placebo on aerobic exercise performance in acute normobaric hypoxia .", "sentence_id": 0}
+{"abstract_id": "24225740", "label": "methods", "text": "Seventeen subjects were randomly assigned in a double-blind fashion to receive a broad-based antioxidants supplement containing beta-carotene , ascorbic acid , d-alpha-tocopherol-succinate , N-acetylcysteine , riboflavin , zinc , and selenium ( antioxidant capsule group -LSB- AO group -RSB- ) , or a combination of alpha-ketoglutaric acid ( - KG ) and @-hydroxymethylfurfural ( @-HMF ; CYL concentrate supplementation group -LSB- CS group -RSB- ) , or placebo ( PL group ) .", "sentence_id": 1}
+{"abstract_id": "24225740", "label": "methods", "text": "Before and after supplementation , subjects performed two incremental cycle-exercise tests until exhaustion .", "sentence_id": 2}
+{"abstract_id": "24225740", "label": "methods", "text": "The first test was conducted under normoxic conditions ( LA , FiO@ of @ % , ~ @ m ) and the second after the @-week supplementation period under normobaric hypoxic conditions ( AHA , FiO@ of @ % , ~ @m ) .", "sentence_id": 3}
+{"abstract_id": "24225740", "label": "results", "text": "In CS peak cycling performance ( peak power ) declined from LA to AHA @ % ( @ % CI : @-@ @ ) less compared with PL ( p = @ ) and @ % ( @ % CI : @-@ @ ) less compared with AO ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24225740", "label": "results", "text": "Better maintenance of aerobic exercise capacity in CS was associated with an attenuated reduction in maximal heart rate in hypoxia .", "sentence_id": 5}
+{"abstract_id": "24225740", "label": "conclusions", "text": "Aerobic exercise performance was less impaired in acute normobaric hypoxia after @ weeks with supplementation of - KG and @-HMF compared with a broad-based antioxidants supplement or PL .", "sentence_id": 6}
+{"abstract_id": "25470228", "label": "objective", "text": "Previous reports of the RAPID-axSpA trial ( NCT@ ) described the efficacy and safety of certolizumab pegol ( CZP ) over @ weeks in patients with axial spondyloarthritis ( SpA ) , including ankylosing spondylitis ( AS ) and nonradiographic axial SpA .", "sentence_id": 0}
+{"abstract_id": "25470228", "label": "objective", "text": "We report efficacy and safety data up to week @ of the study .", "sentence_id": 1}
+{"abstract_id": "25470228", "label": "methods", "text": "The RAPID-axSpA trial is double-blind and placebo-controlled to week @ , dose-blind to week @ , and open-label to week @ .", "sentence_id": 2}
+{"abstract_id": "25470228", "label": "methods", "text": "Outcome variables included Assessment of SpondyloArthritis international Society criteria for @ % and @ % improvement in disease activity ( ASAS@/@ ) , ASAS partial remission responses ( analyzed by nonresponder imputation ) , AS Disease Activity Score ( ASDAS ) , ASDAS inactive disease , ASDAS major improvement , Bath AS Disease Activity Index ( BASDAI ) , Bath AS Functional Index ( BASFI ) , and Bath AS Metrology Index ( BASMI ) linear score ( analyzed by the last observation carried forward method ) .", "sentence_id": 3}
+{"abstract_id": "25470228", "label": "methods", "text": "Safety data were collected for patients treated with @ dose of CZP .", "sentence_id": 4}
+{"abstract_id": "25470228", "label": "results", "text": "Of the @ patients who were randomized , @ received CZP from week @ .", "sentence_id": 5}
+{"abstract_id": "25470228", "label": "results", "text": "Of these , @ % completed week @ , @ % completed week @ , and @ % completed week @ .", "sentence_id": 6}
+{"abstract_id": "25470228", "label": "results", "text": "Improvements in ASAS responses were maintained to week @ ( for ASAS@ , @ % , @ % , and @ % at weeks @ , @ , and @ , respectively ) , as well as improvements in ASDAS , BASDAI ( mean score @ , @ , and @ at weeks @ , @ , and @ , respectively ) , BASFI , and BASMI linear score .", "sentence_id": 7}
+{"abstract_id": "25470228", "label": "results", "text": "Comparable improvements were observed with both dosing regimens ( @ mg every @ weeks or @ mg every @ weeks ) and in patients with AS and those with nonradiographic axial SpA .", "sentence_id": 8}
+{"abstract_id": "25470228", "label": "results", "text": "In the safety set , adverse events occurred in @ patients ( @ % ) and serious adverse events in @ ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "25470228", "label": "results", "text": "No deaths or malignancies were reported .", "sentence_id": 10}
+{"abstract_id": "25470228", "label": "conclusions", "text": "Clinical improvements to week @ in both CZP dosing regimens were sustained to week @ .", "sentence_id": 11}
+{"abstract_id": "25470228", "label": "conclusions", "text": "Similar sustained improvements were observed in AS and nonradiographic axial SpA subpopulations .", "sentence_id": 12}
+{"abstract_id": "25470228", "label": "conclusions", "text": "The safety profile was consistent with previous reports from RAPID-axSpA , with no new safety signals observed with longer exposure .", "sentence_id": 13}
+{"abstract_id": "25301457", "label": "background", "text": "Transradial access ( TRA ) has been associated with reduced access site-related bleeding complications and mortality after percutaneous coronary intervention ( PCI ) .", "sentence_id": 0}
+{"abstract_id": "25301457", "label": "background", "text": "It is unclear , however , whether these observed benefits are influenced by baseline bleeding risk .", "sentence_id": 1}
+{"abstract_id": "25301457", "label": "objective", "text": "This study investigated the relationship between baseline bleeding risk , TRA utilization , and procedure-related outcomes in patients undergoing PCI enrolled in the British Cardiovascular Intervention Society database .", "sentence_id": 2}
+{"abstract_id": "25301457", "label": "methods", "text": "Baseline bleeding risk was calculated by using modified Mehran bleeding risk scores in @,@ PCI procedures performed between @ and @ .", "sentence_id": 3}
+{"abstract_id": "25301457", "label": "methods", "text": "Four categories for bleeding risk were defined for the modified Mehran risk score ( MMRS ) : low ( < @ ) , moderate ( @ to @ ) , high ( @ to @ ) , and very high ( @ ) .", "sentence_id": 4}
+{"abstract_id": "25301457", "label": "methods", "text": "The impact of baseline bleeding risk on @-day mortality and its relationship with access site were studied .", "sentence_id": 5}
+{"abstract_id": "25301457", "label": "results", "text": "TRA was independently associated with a @ % reduction in @-day mortality risk ( odds ratio -LSB- OR -RSB- : @ -LSB- @ % confidence interval ( CI ) : @ to @ -RSB- ; p < @ ) , with the magnitude of mortality reduction related to baseline bleeding risk ( MMRS < @ , OR : @ -LSB- @ % CI : @ to @ -RSB- ; MMRS @ , OR : @ -LSB- @ % CI : @ to @ -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "25301457", "label": "results", "text": "In patients with an MMRS < @ , TRA was used in @,@ ( @ % ) of @,@ PCI procedures ; TRA was used in @,@ ( @ % ) of @,@ PCI procedures in patients with an MMRS @ , illustrating that TRA was used less in those at highest risk from bleeding complications ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25301457", "label": "conclusions", "text": "TRA was independently associated with reduced @-day mortality , and the magnitude of this effect was related to baseline bleeding risk ; those at highest risk of bleeding complications gained the greatest benefit from adoption of TRA during PCI .", "sentence_id": 8}
+{"abstract_id": "25189222", "label": "background", "text": "Patients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment .", "sentence_id": 0}
+{"abstract_id": "25189222", "label": "background", "text": "We aimed to determine whether serum procalcitonin ( PCT ) levels can effectively and safely reduce antibiotic exposure in patients experiencing exacerbations of asthma .", "sentence_id": 1}
+{"abstract_id": "25189222", "label": "methods", "text": "In this randomized controlled trial , a total of @ patients requiring hospitalization for severe acute exacerbations of asthma were screened for eligibility to participate and @ completed the @-month follow-up visit .", "sentence_id": 2}
+{"abstract_id": "25189222", "label": "methods", "text": "Patients were randomized to either PCT-guided ( PCT group ) or standard ( control group ) antimicrobial therapy .", "sentence_id": 3}
+{"abstract_id": "25189222", "label": "methods", "text": "In the control group , patients received antibiotics according to the attending physician 's discretion ; in the PCT group , patients received antibiotics according to an algorithm based on serum PCT levels .", "sentence_id": 4}
+{"abstract_id": "25189222", "label": "methods", "text": "The primary end point was antibiotic exposure ; secondary end points were clinical recovery , length of hospital stay , clinical and laboratory parameters , spirometry , number of asthma exacerbations , emergency room visits , hospitalizations and need for corticosteroid use due to asthma .", "sentence_id": 5}
+{"abstract_id": "25189222", "label": "results", "text": "PCT guidance reduced antibiotic prescription ( @ % versus @ % , respectively ; P < @ ) and antibiotic exposure ( relative risk , @ ; @ % confidence interval , @ to @ ; P < @ ) compared to standard therapy .", "sentence_id": 6}
+{"abstract_id": "25189222", "label": "results", "text": "There were no significant differences in clinical recovery , length of hospital stay or clinical , laboratory and spirometry outcomes in both groups .", "sentence_id": 7}
+{"abstract_id": "25189222", "label": "results", "text": "Number of asthma exacerbations , emergency room visits , hospitalizations and need for corticosteroid use due to asthma were similar during the @-month follow-up period .", "sentence_id": 8}
+{"abstract_id": "25189222", "label": "conclusions", "text": "A PCT-guided strategy allows antibiotic exposure to be reduced in patients with severe acute exacerbation of asthma without apparent harm .", "sentence_id": 9}
+{"abstract_id": "25458910", "label": "background", "text": "Respiratory syncytial virus ( RSV ) bronchiolitis in infancy is a major risk factor for recurrent wheezing and asthma .", "sentence_id": 0}
+{"abstract_id": "25458910", "label": "background", "text": "Because azithromycin attenuated neutrophilic airway inflammation in a murine viral bronchiolitis model , demonstration of similar effects in human subjects might provide a strategy for the prevention of postbronchiolitis recurrent wheezing .", "sentence_id": 1}
+{"abstract_id": "25458910", "label": "objective", "text": "We sought to investigate whether azithromycin treatment during RSV bronchiolitis reduces serum and nasal lavage IL-@ levels and the occurrence of postbronchiolitis recurrent wheezing .", "sentence_id": 2}
+{"abstract_id": "25458910", "label": "methods", "text": "We performed a randomized , double-masked , placebo-controlled proof-of-concept trial in @ otherwise healthy infants hospitalized with RSV bronchiolitis who were treated with azithromycin or placebo for @ days .", "sentence_id": 3}
+{"abstract_id": "25458910", "label": "methods", "text": "IL-@ levels were measured in nasal lavage fluid and serum on randomization , day @ , and day @ ( nasal lavage only ) .", "sentence_id": 4}
+{"abstract_id": "25458910", "label": "methods", "text": "The occurrence of wheezing episodes was assessed monthly over the ensuing @ weeks .", "sentence_id": 5}
+{"abstract_id": "25458910", "label": "results", "text": "Compared with placebo , azithromycin treatment did not reduce serum IL-@ levels at day @ ( P = @ ) but resulted in a greater decrease in nasal lavage fluid IL-@ levels by day @ ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25458910", "label": "results", "text": "Twenty-two percent of azithromycin-treated participants experienced at least @ wheezing episodes compared with @ % of participants in the placebo group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25458910", "label": "results", "text": "Azithromycin treatment resulted in prolonged time to the third wheezing episode ( P = @ ) and in fewer days with respiratory symptoms over the subsequent year in comparison with placebo ( @ vs @ days , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25458910", "label": "conclusions", "text": "In this proof-of-concept study azithromycin treatment during RSV bronchiolitis reduced upper airway IL-@ levels , prolonged the time to the third wheezing episode , and reduced overall respiratory morbidity over the subsequent year .", "sentence_id": 9}
+{"abstract_id": "24687833", "label": "objective", "text": "To evaluate panitumumab plus modified fluorouracil , leucovorin , and oxaliplatin ( mFOLFOX@ ) or bevacizumab plus mFOLFOX@ in patients with previously untreated wild-type ( WT ) KRAS exon @ ( codons @ and @ ) metastatic colorectal cancer ( mCRC ) .", "sentence_id": 0}
+{"abstract_id": "24687833", "label": "objective", "text": "A prespecified secondary objective was to assess treatment effects in an extended RAS analysis that included exons @ , @ , and @ of KRAS and NRAS .", "sentence_id": 1}
+{"abstract_id": "24687833", "label": "methods", "text": "Patients with WT KRAS exon @ tumors were randomly assigned at a one-to-one ratio to panitumumab plus mFOLFOX@ or bevacizumab plus mFOLFOX@ .", "sentence_id": 2}
+{"abstract_id": "24687833", "label": "methods", "text": "The primary end point was progression-free survival ( PFS ) ; secondary end points included overall survival ( OS ) and safety .", "sentence_id": 3}
+{"abstract_id": "24687833", "label": "results", "text": "Of @ randomly assigned patients , @ received treatment .", "sentence_id": 4}
+{"abstract_id": "24687833", "label": "results", "text": "In the WT KRAS exon @ intent-to-treat group , PFS was similar between arms ( hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24687833", "label": "results", "text": "Median OS was @ and @ months in the panitumumab and bevacizumab arms , respectively ( HR , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24687833", "label": "results", "text": "In the WT RAS subgroup ( WT exons @ , @ , and @ of KRAS and NRAS ) , PFS favored the panitumumab arm ( HR , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24687833", "label": "results", "text": "Median OS was @ and @ months ( HR , @ ; @ % CI , @ to @ ; P = @ ) in the panitumumab and bevacizumab arms , respectively .", "sentence_id": 8}
+{"abstract_id": "24687833", "label": "results", "text": "Treatment discontinuation rates because of adverse events were similar between arms .", "sentence_id": 9}
+{"abstract_id": "24687833", "label": "conclusions", "text": "PFS was similar and OS was improved with panitumumab relative to bevacizumab when combined with mFOLFOX@ in patients with WT KRAS exon @ tumors .", "sentence_id": 10}
+{"abstract_id": "24687833", "label": "conclusions", "text": "Patients with WT RAS tumors seemed to experience more clinical benefit with anti-epidermal growth factor receptor therapy .", "sentence_id": 11}
+{"abstract_id": "25059121", "label": "background", "text": "Although effectiveness of web-based interventions on lifestyle changes are recognized , the potential of such programs on metabolic syndrome has not been explored .", "sentence_id": 0}
+{"abstract_id": "25059121", "label": "background", "text": "We describe the protocol of a randomized controlled trial that aims to determine the feasibility , acceptability , usability , and effectiveness of interactive technology on lifestyle intervention in a population with metabolic syndrome .", "sentence_id": 1}
+{"abstract_id": "25059121", "label": "methods", "text": "This is a two-arm randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "25059121", "label": "methods", "text": "The study includes @ participants ( n = @ per arm ) who will be recruited via online registration on the study website .", "sentence_id": 3}
+{"abstract_id": "25059121", "label": "methods", "text": "The inclusion criteria are that they should have metabolic syndrome and have access to the Internet .", "sentence_id": 4}
+{"abstract_id": "25059121", "label": "methods", "text": "All participants will receive information on dietary intake and physical activity through the study website .", "sentence_id": 5}
+{"abstract_id": "25059121", "label": "methods", "text": "The intervention group will receive additional resources via the study website including interactive Healthy Heart Profile and calorie restricted diet tailored to the participants .", "sentence_id": 6}
+{"abstract_id": "25059121", "label": "methods", "text": "The primary outcomes are feasibility , acceptability , usability , and the change in metabolic syndrome components .", "sentence_id": 7}
+{"abstract_id": "25059121", "label": "methods", "text": "The secondary outcomes are comparing quality of life , physical activity and food intake among the study arms .", "sentence_id": 8}
+{"abstract_id": "25059121", "label": "methods", "text": "The participants will be followed up to @ months with data collection scheduled at baseline , @ and @ months .", "sentence_id": 9}
+{"abstract_id": "25059121", "label": "conclusions", "text": "There is a need for developing and evaluating web-based interventions that target people with high risk for cardiovascular diseases .", "sentence_id": 10}
+{"abstract_id": "25059121", "label": "conclusions", "text": "This study will therefore make an important contribution to this novel field of research and practice .", "sentence_id": 11}
+{"abstract_id": "24829969", "label": "objective", "text": "The purpose of this ongoing randomized study was to assess differences in bone level changes and success rates using implants supporting single crowns in the posterior mandible either with platform matched or platform switched abutments .", "sentence_id": 0}
+{"abstract_id": "24829969", "label": "methods", "text": "Patients aged @ and above , missing at least two teeth in the posterior mandible and with a natural tooth mesial to the most proximal implant site were enrolled .", "sentence_id": 1}
+{"abstract_id": "24829969", "label": "methods", "text": "Randomization followed implant placement .", "sentence_id": 2}
+{"abstract_id": "24829969", "label": "methods", "text": "Definitive restorations were placed after a minimum transgingival healing period of @ weeks .", "sentence_id": 3}
+{"abstract_id": "24829969", "label": "methods", "text": "Changes in crestal bone level from surgery and loading ( baseline ) to @-month post-loading were radiographically measured .", "sentence_id": 4}
+{"abstract_id": "24829969", "label": "methods", "text": "Implant survival and success were determined .", "sentence_id": 5}
+{"abstract_id": "24829969", "label": "results", "text": "Sixty-eight patients received @ implants in the platform switching group and @ in the other one .", "sentence_id": 6}
+{"abstract_id": "24829969", "label": "results", "text": "The difference of mean marginal bone level change from surgery to @ months was significant between groups ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24829969", "label": "results", "text": "Radiographical mean bone gain or no bone loss from loading was noted for @ % of the platform switching and @ % of the platform matching implants .", "sentence_id": 8}
+{"abstract_id": "24829969", "label": "results", "text": "Implant success rates were @ % and @ % , respectively .", "sentence_id": 9}
+{"abstract_id": "24829969", "label": "conclusions", "text": "Within the same implant system the platform switching concept showed a positive effect on marginal bone levels when compared with restorations with platform matching .", "sentence_id": 10}
+{"abstract_id": "24245880", "label": "background", "text": "Pronounced nasojugal groove ( tear trough deformity ) is one of the landmarks of aging .", "sentence_id": 0}
+{"abstract_id": "24245880", "label": "background", "text": "Hyaluronic acid filler can be used for attenuating the nasojugal sulcus but irregular lumpness and overcorrection are common adverse reactions .", "sentence_id": 1}
+{"abstract_id": "24245880", "label": "objective", "text": "We evaluated the effect of Restylane Vital with its specialized injector on volume correction and skin tone of nasojugal groove .", "sentence_id": 2}
+{"abstract_id": "24245880", "label": "methods", "text": "Ten Korean women were enrolled in this study .", "sentence_id": 3}
+{"abstract_id": "24245880", "label": "methods", "text": "Subjects were randomized to be injected a stabilized hyaluronic acid-based gel of nonanimal origin ( NAHSA injector , Restylane Vital , Q-med ) on one side of nasojugal groove , with the other side paired as control .", "sentence_id": 4}
+{"abstract_id": "24245880", "label": "methods", "text": "The treatment was performed in one session .", "sentence_id": 5}
+{"abstract_id": "24245880", "label": "methods", "text": "Outcome assessments included standardized photography , mexameter , and spectrometer for skin tone , global evaluation by blinded investigators , and patients ' self-assessment .", "sentence_id": 6}
+{"abstract_id": "24245880", "label": "methods", "text": "An assessment was made before treatment , immediately after treatment , and @ , @ , and @ months after the treatment .", "sentence_id": 7}
+{"abstract_id": "24245880", "label": "results", "text": "All patients reported a high degree of satisfaction .", "sentence_id": 8}
+{"abstract_id": "24245880", "label": "results", "text": "Duration of overall effect varied among the patients .", "sentence_id": 9}
+{"abstract_id": "24245880", "label": "results", "text": "Correction of the nasojugal groove with a Restylane Vital injector causes minimal tissue trauma and allows exact placement of hyaluronic acid .", "sentence_id": 10}
+{"abstract_id": "24245880", "label": "results", "text": "Restylane Vital injector offers more predictable results and a lower incidence of adverse effects than more commonly used techniques .", "sentence_id": 11}
+{"abstract_id": "24245880", "label": "conclusions", "text": "Hyaluronic acid filler intradermal injection with special injector is a safe and effective method for correction of nasojugal groove .", "sentence_id": 12}
+{"abstract_id": "24796048", "label": "objective", "text": "To evaluate the efficacy and safety of acupuncture-moxibustion combined with modified Mojie tablet ( see text ) in the prevention of the recurrence of endometriosis ( EMS ) after laparoscopic surgery .", "sentence_id": 0}
+{"abstract_id": "24796048", "label": "methods", "text": "After laparoscopic surgery , @ cases of EMS were randomized into an acupuncture-moxibustion group , a western medication group , a Chinese medication group and a combined therapy of acupuncture-moxibustion and Chinese medication group ( combined therapy group ) , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "24796048", "label": "methods", "text": "In the acupuncture-moxibustion group , acupuncture was applied at Xuehai ( SP @ ) , Sanyinjiao ( SP @ ) and Guanyuan ( CV @ ) ; the isolated moxibustion with ginger was used at Guanyuan ( CV @ ) , once a day , twice a week .", "sentence_id": 2}
+{"abstract_id": "24796048", "label": "methods", "text": "In the western medication group , gestrinone was prescribed for oral administration , @ mg , once a day , twice a week .", "sentence_id": 3}
+{"abstract_id": "24796048", "label": "methods", "text": "In the Chinese medication group , the self-prepared Mojie tablet were prescribed for oral administration .", "sentence_id": 4}
+{"abstract_id": "24796048", "label": "methods", "text": "In the combined therapy group , acupuncture , moxibustion and modified Mojie tablet for oral administration were used in combination .", "sentence_id": 5}
+{"abstract_id": "24796048", "label": "methods", "text": "The therapeutic methods were same as the acupuncture-moxibustion group and the Chinese medication group .", "sentence_id": 6}
+{"abstract_id": "24796048", "label": "methods", "text": "Totally , the treatment of @ months was required .", "sentence_id": 7}
+{"abstract_id": "24796048", "label": "methods", "text": "Separately , before treatment , after treatment , in @ months after treatment and in @ months after treatment , EHP-@ score ( endometriosis health profile-@ ) , the abdominal/vaginal ultrasound examination , serum CA@ detection and safety index ( ALT detection ) were compared in patients among @ groups .", "sentence_id": 8}
+{"abstract_id": "24796048", "label": "results", "text": "In @ and @ months after treatment , the positive rates of EHP-@ score were @ % ( @/@ ) in the combined therapy group and @ % ( @/@ ) in the acupuncture-moxibuston group , which were all lower significantly than @ % ( @/@ ) in the western medication group ( both P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24796048", "label": "results", "text": "In follow-up stage of @ months after treatment , there was no recurrence case in abdominal lviginal ultrasound examination in the combined therapy group , which was lower than @ % ( @/@ ) in the western medication group ( P < @ ) ; the serum CA@ detection in the combined therapy group did not find any abnormal case , which was lower than @ % ( @/@ ) in the western medication group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24796048", "label": "results", "text": "At the end of treatment session and in the follow-up stage of @ months after treatment , the abnormal rate of ALT were @ % ( @/@ ) and @ % ( @/@ ) in the western medication group , which were higher than those in any of the rest groups ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24796048", "label": "results", "text": "In the follow-up stage of @ months after treatment , there were @ abnormal cases of ALT in the western medication group , but which was not different significantly as compared with the rest groups ( P > @ ) .", "sentence_id": 12}
+{"abstract_id": "24796048", "label": "conclusions", "text": "Acupuncture and moxibustion combined with modified Mojie tablet effectively prevent from the recurrence of EMS after laparoscopic surgery and improve the life quality of the patients .", "sentence_id": 13}
+{"abstract_id": "24796048", "label": "conclusions", "text": "This combined therapy brings less damage on the liver as compared with the western medication of gestrinone and indicates its definite efficacy and safety .", "sentence_id": 14}
+{"abstract_id": "24403197", "label": "background", "text": "Considering the increasing incidence of chronic kidney disease and the increased use of peritoneal dialysis , we wanted to assess whether the multidisciplinary management of patients in peritoneal dialysis might produce improvement in the quality of patients ' lives when compared to management by a routine team of operators .", "sentence_id": 0}
+{"abstract_id": "24403197", "label": "methods", "text": "Our study observed @ patients on peritoneal dialysis in our Department between @ and @ .", "sentence_id": 1}
+{"abstract_id": "24403197", "label": "methods", "text": "They were randomly assigned to either group A , the routine team which consisted of a nephrologist and a nurse , or group B , a multidisciplinary team comprising several medical specialists , a nurse , a psychologist and a social worker .", "sentence_id": 2}
+{"abstract_id": "24403197", "label": "methods", "text": "Two tests , KDQOL-SF and MMPI-@ , were administered to both groups .", "sentence_id": 3}
+{"abstract_id": "24403197", "label": "results", "text": "In group B , the number of days of hospitalization and day hospital were more than @ % lower when compared to group A.", "sentence_id": 4}
+{"abstract_id": "24403197", "label": "results", "text": "The multidisciplinary team achieved better results with the KDQOL-SF test with regards to both emotional and objective dimensions .", "sentence_id": 5}
+{"abstract_id": "24403197", "label": "results", "text": "The Pearson coefficient between the results of the two questionnaires shows how multidisciplinary management can positively influence the perceived well-being of the patient and his or her adherence to treatment .", "sentence_id": 6}
+{"abstract_id": "24403197", "label": "conclusions", "text": "In a multidisciplinary team , each operator , in addition to his or her specific role , also contributes to the achievement of the overall objective , namely of ensuring an optimal quality of life to the patient on peritoneal dialysis thereby allowing these patients to continue their professional and social lives .", "sentence_id": 7}
+{"abstract_id": "25607594", "label": "objective", "text": "Changes in pulmonary dynamics following laparotomy are well documented .", "sentence_id": 0}
+{"abstract_id": "25607594", "label": "objective", "text": "Deep breathing exercises , with or without incentive spirometry , may help counteract postoperative decreased vital capacity ; however , the evidence for the role of incentive spirometry in the prevention of postoperative atelectasis is inconclusive .", "sentence_id": 1}
+{"abstract_id": "25607594", "label": "objective", "text": "Furthermore , data are scarce regarding the prevention of postoperative atelectasis in sub-Saharan Africa .", "sentence_id": 2}
+{"abstract_id": "25607594", "label": "objective", "text": "To determine the effect of the use of incentive spirometry on pulmonary function following exploratory laparotomy as measured by forced vital capacity ( FVC ) .", "sentence_id": 3}
+{"abstract_id": "25607594", "label": "methods", "text": "This was a single-center , randomized clinical trial performed at Kamuzu Central Hospital , Lilongwe , Malawi .", "sentence_id": 4}
+{"abstract_id": "25607594", "label": "methods", "text": "Study participants were adult patients who underwent exploratory laparotomy and were randomized into the intervention or control groups ( standard of care ) from February @ to November @ , @ .", "sentence_id": 5}
+{"abstract_id": "25607594", "label": "methods", "text": "All patients received routine postoperative care , including instructions for deep breathing and early ambulation .", "sentence_id": 6}
+{"abstract_id": "25607594", "label": "methods", "text": "We used bivariate analysis to compare outcomes between the intervention and control groups .", "sentence_id": 7}
+{"abstract_id": "25607594", "label": "methods", "text": "Adult patients who underwent exploratory laparotomy participated in postoperative deep breathing exercises .", "sentence_id": 8}
+{"abstract_id": "25607594", "label": "methods", "text": "Patients in the intervention group received incentive spirometers .", "sentence_id": 9}
+{"abstract_id": "25607594", "label": "methods", "text": "We assessed pulmonary function using a peak flow meter to measure FVC in both groups of patients .", "sentence_id": 10}
+{"abstract_id": "25607594", "label": "methods", "text": "Secondary outcomes , such as hospital length of stay and mortality , were obtained from the medical records .", "sentence_id": 11}
+{"abstract_id": "25607594", "label": "results", "text": "A total of @ patients were randomized ( @ in each arm ) .", "sentence_id": 12}
+{"abstract_id": "25607594", "label": "results", "text": "The median age in the intervention and control groups was @ years ( interquartile range , @-@ years ) and @ years ( interquartile range , @-@ years ) , respectively .", "sentence_id": 13}
+{"abstract_id": "25607594", "label": "results", "text": "Men predominated in both groups , and most patients underwent emergency procedures ( @ % in the intervention group and @ % in the control group ) .", "sentence_id": 14}
+{"abstract_id": "25607594", "label": "results", "text": "Mean initial FVC did not differ significantly between the intervention and control groups ( @ and @ L , respectively ; P = @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 15}
+{"abstract_id": "25607594", "label": "results", "text": "Although patients in the intervention group tended to have higher final FVC measurements , the change between the first and last measured FVC was not statistically significant ( @ and @ L , respectively ; P = @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 16}
+{"abstract_id": "25607594", "label": "results", "text": "Likewise , hospital length of stay did not differ significantly between groups .", "sentence_id": 17}
+{"abstract_id": "25607594", "label": "results", "text": "Overall postoperative mortality was @ % , with a higher mortality rate in the control group compared with the intervention group ( @ % and @ % , respectively ; P = @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 18}
+{"abstract_id": "25607594", "label": "conclusions", "text": "Education and provision of incentive spirometry for unmonitored patient use does not result in statistically significant improvement in pulmonary dynamics following laparotomy .", "sentence_id": 19}
+{"abstract_id": "25607594", "label": "conclusions", "text": "We would not recommend the addition of incentive spirometry to the current standard of care in this resource-constrained environment .", "sentence_id": 20}
+{"abstract_id": "24532997", "label": "objective", "text": "To assess the effect of armodafinil on task-related prefrontal cortex activation using functional magnetic resonance imaging ( fMRI ) in patients with obstructive sleep apnea ( OSA ) and excessive sleepiness despite continuous positive airway pressure ( CPAP ) therapy .", "sentence_id": 0}
+{"abstract_id": "24532997", "label": "methods", "text": "This @-week , multicenter , prospective , randomized , double-blind , placebo-controlled , parallel-group study was conducted at five neuroimaging sites and four collaborating clinical study centers in the United States .", "sentence_id": 1}
+{"abstract_id": "24532997", "label": "methods", "text": "Patients were @ right-handed or ambidextrous men and women aged between @ and @ years , with OSA and persistent sleepiness , as determined by multiple sleep latency and Epworth Sleepiness Scale scores , despite effective , stable use of CPAP .", "sentence_id": 2}
+{"abstract_id": "24532997", "label": "methods", "text": "Treatment was randomized ( @:@ ) to once-daily armodafinil @ mg or placebo .", "sentence_id": 3}
+{"abstract_id": "24532997", "label": "methods", "text": "The primary efficacy outcome was a change from baseline at week @ in the volume of activation meeting the predefined threshold in the dorsolateral prefrontal cortex during a @-back working memory task .", "sentence_id": 4}
+{"abstract_id": "24532997", "label": "methods", "text": "The key secondary measure was the change in task response latency .", "sentence_id": 5}
+{"abstract_id": "24532997", "label": "results", "text": "No significant differences were observed between treatment groups in the primary or key secondary outcomes .", "sentence_id": 6}
+{"abstract_id": "24532997", "label": "results", "text": "Armodafinil was generally well tolerated .", "sentence_id": 7}
+{"abstract_id": "24532997", "label": "results", "text": "The most common adverse events ( occurring in more than one patient -LSB- @ % -RSB- ) were headache ( @ % ) , nasopharyngitis ( @ % ) , and diarrhea ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24532997", "label": "conclusions", "text": "Armodafinil did not improve fMRI-measured functional brain activation in CPAP-treated patients with OSA and excessive sleepiness .", "sentence_id": 9}
+{"abstract_id": "24568271", "label": "background", "text": "Antisocial behaviour and adult criminality often have their origins in childhood and are best addressed early in the child 's life using evidence-based treatments such as the ` Incredible Years Parent Programme ' .", "sentence_id": 0}
+{"abstract_id": "24568271", "label": "background", "text": "However , families with additional risk factors who are at highest risk for poor outcomes do not always make sufficient change while attending such programmes .", "sentence_id": 1}
+{"abstract_id": "24568271", "label": "background", "text": "Additional support to address barriers and improve implementation of positive parenting strategies while these families attend the Incredible Years Programme may improve overall outcomes.The study aims to evaluate the efficacy of adding a structured home visiting intervention ( Home Parent Support ) to improve outcomes in families most at risk of poor treatment response from the Incredible Years intervention .", "sentence_id": 2}
+{"abstract_id": "24568271", "label": "background", "text": "This study will inform the design of a larger prospective randomised controlled trial .", "sentence_id": 3}
+{"abstract_id": "24568271", "label": "methods", "text": "A pilot single-blind , parallel , superiority , randomised controlled trial .", "sentence_id": 4}
+{"abstract_id": "24568271", "label": "methods", "text": "Randomisation will be undertaken using a computer-generated sequence in a @:@ ratio to the two treatments arranged in permuted blocks with stratification by age , sex , and ethnicity .", "sentence_id": 5}
+{"abstract_id": "24568271", "label": "methods", "text": "One hundred and twenty six participants enrolled in the Incredible Years Parent Programme who meet the high-risk criteria will be randomly allocated to receive either Incredible Years Parent Programme and Home Parent Support , or the Incredible Years Parent Programme alone .", "sentence_id": 6}
+{"abstract_id": "24568271", "label": "methods", "text": "The Home Parent Support is a @-session structured home visiting intervention provided by a trained therapist , alongside the usual Incredible Years Parent Programme , to enhance the adoption of key parenting skills .", "sentence_id": 7}
+{"abstract_id": "24568271", "label": "methods", "text": "The primary outcome is the change in child behaviour from baseline to post-intervention in parent reported Eyberg Child Behavior Inventory Problem Scale .", "sentence_id": 8}
+{"abstract_id": "24568271", "label": "conclusions", "text": "This is the first formal evaluation of adding Home Parent Support alongside Incredible Years Parent Programme for families with risk factors who typically have poorer treatment outcomes .", "sentence_id": 9}
+{"abstract_id": "24568271", "label": "conclusions", "text": "We anticipate that the intervention will help vulnerable families stay engaged , strengthen the adoption of effective parenting strategies , and improve outcomes for both the children and families .", "sentence_id": 10}
+{"abstract_id": "24717011", "label": "background", "text": "Childhood obesity is a growing concern in Sweden .", "sentence_id": 0}
+{"abstract_id": "24717011", "label": "background", "text": "Children with overweight and obesity run a high risk of becoming obese as adults , and are likely to develop comorbidities .", "sentence_id": 1}
+{"abstract_id": "24717011", "label": "background", "text": "Despite the immense demand , there is still a lack of evidence-based comprehensive prevention programmes targeting pre-school children and their families in primary health care settings .", "sentence_id": 2}
+{"abstract_id": "24717011", "label": "background", "text": "The aims are to describe the design and methodology of the PRIMROSE cluster-randomised controlled trial , assess the relative validity of a food frequency questionnaire , and describe the baseline characteristics of the eligible young children and their mothers .", "sentence_id": 3}
+{"abstract_id": "24717011", "label": "methods", "text": "The PRIMROSE trial targets first-time parents and their children at Swedish child health centres ( CHC ) in eight counties in Sweden .", "sentence_id": 4}
+{"abstract_id": "24717011", "label": "methods", "text": "Randomisation is conducted at the CHC unit level .", "sentence_id": 5}
+{"abstract_id": "24717011", "label": "methods", "text": "CHC nurses employed at the participating CHC received training in carrying out the intervention alongside their provision of regular services .", "sentence_id": 6}
+{"abstract_id": "24717011", "label": "methods", "text": "The intervention programme , starting when the child is @-@months of age and ending at age @ , is based on social cognitive theory and employs motivational interviewing .", "sentence_id": 7}
+{"abstract_id": "24717011", "label": "methods", "text": "Primary outcomes are children 's body mass index and waist circumference at fouryears .", "sentence_id": 8}
+{"abstract_id": "24717011", "label": "methods", "text": "Secondary outcomes are children 's and mothers ' eating habits ( assessed by a food frequency questionnaire ) , and children 's and mothers ' physical activity ( measured by accelerometer and a validated questionnaire ) , and mothers ' body mass index and waist circumference .", "sentence_id": 9}
+{"abstract_id": "24717011", "label": "conclusions", "text": "The on-going population-based PRIMROSE trial , which targets childhood obesity , is embedded in the regular national ( routine ) preventive child health services that are available free-of-charge to all young families in Sweden .", "sentence_id": 10}
+{"abstract_id": "24717011", "label": "conclusions", "text": "Of the participants ( n = @ ) , @ intervention and @ control mothers ( @ % ) responded to the validated physical activity and food frequency questionnaire at baseline ( i.e. , before the first intervention session , or , for children in the control group , before they reached @months of age ) .", "sentence_id": 11}
+{"abstract_id": "24717011", "label": "conclusions", "text": "The food frequency questionnaire showed acceptable relative validity when compared with an @-day food diary .", "sentence_id": 12}
+{"abstract_id": "24717011", "label": "conclusions", "text": "We are not aware of any previous RCT , concerned with the primary prevention of childhood obesity through sessions at CHC that addresses healthy eating habits and physical activity in the context of a routine child health services programme .", "sentence_id": 13}
+{"abstract_id": "25074771", "label": "objective", "text": "To investigate the effects of lutein supplementation on plasma lutein concentrations and the macular pigment optical density ( MPOD ) in central serous chorioretinopathy ( CSC ) .", "sentence_id": 0}
+{"abstract_id": "25074771", "label": "methods", "text": "In this double-masked placebo-controlled study , @ patients received lutein @ mg/d and @ received placebo .", "sentence_id": 1}
+{"abstract_id": "25074771", "label": "methods", "text": "The plasma lutein concentration and MPOD using autofluorescence spectrometry ( density unit , DU ) were measured at baseline and @ and @ months .", "sentence_id": 2}
+{"abstract_id": "25074771", "label": "results", "text": "The mean plasma lutein concentrations and MPOD values in the lutein and control groups , respectively , were @ and @ ng/mL and @ and @ DU at baseline ; @ and @ ng/mL and @ and @ DU at @ month ; and @ and @ ng/mL and @ and @ DU at @ months .", "sentence_id": 3}
+{"abstract_id": "25074771", "label": "results", "text": "The plasma concentration in the lutein group was significantly higher than in controls at @ and @ months ( P < @ for both comparisons ) ; however , the MPOD values did not differ significantly between groups at @ ( P = @ ) or @ months ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25074771", "label": "results", "text": "In patients with a plasma lutein concentration below the mean level in @ age-matched healthy subjects ( mean @ ng/mL ; n = @ in lutein group , n = @ in control group ) , the control MPOD values significantly ( P = @ ) decreased at @ months ( mean baseline , @ DU ; @ months , @ DU ) .", "sentence_id": 5}
+{"abstract_id": "25074771", "label": "results", "text": "The MPOD in the lutein group remained at the baseline level ( mean baseline , @ DU ; @ months , @ DU ) ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25074771", "label": "conclusions", "text": "The MPOD did not increase in patients with CSC with short-term lutein supplementation ; however , among patients with low plasma lutein , supplemental lutein prevented a decline in MPOD that was observed in control subjects ( www.umin.ac.jp/ctr number , UMIN@ ) .", "sentence_id": 7}
+{"abstract_id": "24923683", "label": "background", "text": "Fluid therapy is widely used in critically ill patients to restore effective intravascular volume and improve organ perfusion .", "sentence_id": 0}
+{"abstract_id": "24923683", "label": "background", "text": "Recent studies have questioned the administration of colloid-based solutions , especially if containing hydroxyethyl starch ( HES ) , in different ICU populations ; however , there is still uncertainty on the use of colloids as initial fluid therapy for early resuscitation .", "sentence_id": 1}
+{"abstract_id": "24923683", "label": "methods", "text": "The aim of this study was to investigate the effect of two different resuscitation fluid strategies on the mortality of patients with shock .", "sentence_id": 2}
+{"abstract_id": "24923683", "label": "methods", "text": "In a multicentric ( @ ICUs ) , controlled , open-label trial ( from February @ to August @ ) , the authors randomized patients with signs of acute hypovolemia , defined by the combination of hypotension , evidence of low filling pressures or cardiac index and at least two signs of tissue hypoperfusion ( such as altered consciousness , mottled skin , oliguria , lactate levels > @ mmol/L ) , to received either a colloid - or crystalloid-based therapy .", "sentence_id": 3}
+{"abstract_id": "24923683", "label": "methods", "text": "Both cohorts received maintenance fluids consisting in isotonic crystalloids and albumin in case of severe hypoalbuminemia ( < @ g/dL ) .", "sentence_id": 4}
+{"abstract_id": "24923683", "label": "methods", "text": "Exclusion criteria included previous fluid therapy , pregnancy , brain death , extended burns , chronic hemodialysis or liver disease , known coagulopathy , acute anaphylaxis , dehydration and hypotension due to sedative drugs .", "sentence_id": 5}
+{"abstract_id": "24923683", "label": "results", "text": "Among the @ eligible patients , @ were eventually randomized in one of the two groups .", "sentence_id": 6}
+{"abstract_id": "24923683", "label": "results", "text": "The @-day mortality was @ % in the colloid and @ % in the crystalloid group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24923683", "label": "results", "text": "In the sub-group analysis , similar mortality rates were reported for shock due to hypovolemia , sepsis or trauma .", "sentence_id": 8}
+{"abstract_id": "24923683", "label": "results", "text": "Also , the use of continuous renal replacement therapy was similar between groups ( @ % vs. @ % , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24923683", "label": "results", "text": "There were more days alive without mechanical ventilation or vasopressors during the first @ and @ days and a lower @-day mortality in the colloid group .", "sentence_id": 10}
+{"abstract_id": "24923683", "label": "conclusions", "text": "These data suggest that mortality was not increased and probably decreased with the use of colloids in different forms of shock requiring early fluid resuscitation .", "sentence_id": 11}
+{"abstract_id": "24923683", "label": "conclusions", "text": "We discussed herein some methodological issues that may explain the discrepancies of this trial with the other studies developed in the same field .", "sentence_id": 12}
+{"abstract_id": "25515123", "label": "background", "text": "Cochlear implantation with the aim of hearing preservation for combined electric-acoustic stimulation ( EAS ) is the therapy of choice for patients with residual low-frequency hearing .", "sentence_id": 0}
+{"abstract_id": "25515123", "label": "background", "text": "Preserved residual acoustic hearing has a positive effect on speech intelligibility in difficult noise conditions .", "sentence_id": 1}
+{"abstract_id": "25515123", "label": "objective", "text": "The goal of this study was to assess speech reception thresholds in various complex noise conditions for patients with EAS in comparison with patients using bilateral cochlear implants ( CI ) .", "sentence_id": 2}
+{"abstract_id": "25515123", "label": "methods", "text": "Speech perception in noise was measured for bilateral CI and EAS patient groups .", "sentence_id": 3}
+{"abstract_id": "25515123", "label": "methods", "text": "A total of @ listeners with normal hearing served as a control group .", "sentence_id": 4}
+{"abstract_id": "25515123", "label": "methods", "text": "Speech reception thresholds ( SRT ) were measured using a closed-set sentence matrix test .", "sentence_id": 5}
+{"abstract_id": "25515123", "label": "methods", "text": "Speech was presented with a single source in frontal position ; noise was presented in frontal position or in a multisource noise field ( MSNF ) consisting of a four-loudspeaker array with independent noise sources .", "sentence_id": 6}
+{"abstract_id": "25515123", "label": "methods", "text": "Modulated speech-simulating noise and pseudocontinuous noise served respectively as interference signal with different temporal characteristics .", "sentence_id": 7}
+{"abstract_id": "25515123", "label": "results", "text": "The average SRTs in the EAS group were significantly better in all test conditions than those of the group with bilateral CI .", "sentence_id": 8}
+{"abstract_id": "25515123", "label": "results", "text": "Both user groups showed significant improvement in the MSNF condition compared with the frontal noise condition as a result of bilateral interaction .", "sentence_id": 9}
+{"abstract_id": "25515123", "label": "results", "text": "The normal-hearing control group was able to use short temporal gaps in modulated noise to improve speech perception in noise ( gap listening ) .", "sentence_id": 10}
+{"abstract_id": "25515123", "label": "results", "text": "This effect was absent in both implanted user groups .", "sentence_id": 11}
+{"abstract_id": "25515123", "label": "conclusions", "text": "Patients with combined EAS in one ear and a hearing aid in the contralateral ear show significantly improved speech perception in complex noise conditions compared with bilateral CI recipients .", "sentence_id": 12}
+{"abstract_id": "24702710", "label": "background", "text": "Patient-reported outcomes ( PROs ) are particularly relevant in influenza vaccine trials in the elderly where reduction in symptom severity could prevent illness-related functional impairment .", "sentence_id": 0}
+{"abstract_id": "24702710", "label": "objective", "text": "To evaluate PROs in people aged @ years receiving two different vaccines .", "sentence_id": 1}
+{"abstract_id": "24702710", "label": "methods", "text": "This was a phase III , randomised , observer-blind study ( NCT@ ) of the AS@-adjuvanted inactivated trivalent split-virion influenza vaccine ( AS@-TIV ) versus non-adjuvanted vaccine ( TIV ) .", "sentence_id": 2}
+{"abstract_id": "24702710", "label": "methods", "text": "Using the FluiiQ questionnaire , symptom ( systemic , respiratory , total ) and life impact ( activities , emotions , relationships ) scores were computed as exploratory endpoints , with minimal important difference ( MID ) in influenza severity between vaccines considered post-hoc as > @ % .", "sentence_id": 3}
+{"abstract_id": "24702710", "label": "methods", "text": "Vaccine efficacy of AS@-TIV relative to TIV in severe influenza ( hospitalisation , complication , most severe one-third of episodes based on the area under the curve for systemic symptom score ) was calculated post-hoc .", "sentence_id": 4}
+{"abstract_id": "24702710", "label": "methods", "text": "The main analyses ( descriptive ) were conducted in the according-to-protocol cohort ( n = @ AS@-TIV , n = @ TIV ) for influenza confirmed by culture or reverse transcriptase polymerase chain reaction .", "sentence_id": 5}
+{"abstract_id": "24702710", "label": "results", "text": "Mean systemic symptom , total symptom and impact on activities scores were lower with AS@-TIV versus TIV .", "sentence_id": 6}
+{"abstract_id": "24702710", "label": "results", "text": "Mean respiratory symptom , impact on emotions and impact on relationships scores were similar .", "sentence_id": 7}
+{"abstract_id": "24702710", "label": "results", "text": "Influenza tended to be less severe with AS@-TIV , but the MID was reached only for impact on activities ( mean @ % ) .", "sentence_id": 8}
+{"abstract_id": "24702710", "label": "results", "text": "Relative vaccine efficacy in severe influenza was @ % ( @ % CI : @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "24702710", "label": "conclusions", "text": "AS@-TIV had advantages over TIV in impact on systemic symptoms and activities as measured by the FluiiQ in elderly people .", "sentence_id": 10}
+{"abstract_id": "24702710", "label": "conclusions", "text": "Higher efficacy of AS@-TIV relative to TIV was shown for prevention of severe illness .", "sentence_id": 11}
+{"abstract_id": "25733460", "label": "background", "text": "Dietary patterns characterized by high intakes of fruits and vegetables , whole grains , low-fat dairy products , and low glycemic load have been associated with lower type @ diabetes mellitus ( T@DM ) risk .", "sentence_id": 0}
+{"abstract_id": "25733460", "label": "background", "text": "In contrast , dietary patterns that include high intakes of refined grains , processed meats , and high amounts of added sugars have been associated with increased T@DM risk .", "sentence_id": 1}
+{"abstract_id": "25733460", "label": "objective", "text": "This randomized , @-period crossover trial compared the effects of dairy and sugar-sweetened product ( SSP ) consumption on insulin sensitivity and pancreatic - cell function in men and women at risk of the development of T@DM who habitually consume sugar-sweetened beverages .", "sentence_id": 2}
+{"abstract_id": "25733460", "label": "methods", "text": "In a randomized , controlled crossover trial , participants consumed dairy products ( @ mL/d @ % milk and @ g/d low-fat yogurt ) and SSPs ( @ mL/d nondiet soda and @ g/d nondairy pudding ) , each for @ wk , with a @-wk washout between treatments .", "sentence_id": 3}
+{"abstract_id": "25733460", "label": "methods", "text": "A liquid meal tolerance test ( LMTT ) was administered at baseline and the end of each period .", "sentence_id": 4}
+{"abstract_id": "25733460", "label": "results", "text": "Participants were @ % female with a mean age and body mass index of @ y and @ kg/m ( @ ) , respectively .", "sentence_id": 5}
+{"abstract_id": "25733460", "label": "results", "text": "Changes from baseline were significantly different between dairy product and SSP conditions for median homeostasis model assessment @-insulin sensitivity ( HOMA@ - % S ) ( @ vs. -@ % , respectively , P = @ ; baseline = @ % ) , mean LMTT disposition index ( -@ vs. -@ , respectively , P = @ ; baseline = @ ) , mean HDL cholesterol ( @ vs. -@ % , respectively , P = @ ; baseline = @ mg/dL ) , and mean serum @-hydroxyvitamin D -LSB- @ ( OH ) D -RSB- ( @ vs. -@ , respectively , P = @ ; baseline = @ g/L ) .", "sentence_id": 6}
+{"abstract_id": "25733460", "label": "results", "text": "Changes from baseline in LMTT Matsuda insulin sensitivity index ( -@ vs. -@ , respectively ; baseline = @ ) and mean HOMA@ -- cell function ( -@ vs. @ % , respectively ; baseline = @ % ) did not differ significantly between treatments .", "sentence_id": 7}
+{"abstract_id": "25733460", "label": "conclusions", "text": "These results suggest that SSP consumption is associated with less favorable values for HOMA@ - % S , LMTT disposition index , HDL cholesterol , and serum @ ( OH ) D in men and women at risk of T@DM vs. baseline values and values during dairy product consumption .", "sentence_id": 8}
+{"abstract_id": "25733460", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 9}
+{"abstract_id": "25205361", "label": "background", "text": "Neurofibromatosis type @ ( NF@ ) is an autosomal dominant disorder with an estimated prevalence of about @/@ , independent of ethnicity , race , or gender .", "sentence_id": 0}
+{"abstract_id": "25205361", "label": "background", "text": "Attention Deficit Hyperactivity like Disorder ( ADHD ) - like characteristics are often reported in patients with NF@ .", "sentence_id": 1}
+{"abstract_id": "25205361", "label": "background", "text": "We hypothesised that learning disabilities in NF@ children were related to ADHD symptoms .", "sentence_id": 2}
+{"abstract_id": "25205361", "label": "background", "text": "Treatment with methylphenidate ( MPD ) has improved learning disabilities in ADHD by acting on neurotransmitters .", "sentence_id": 3}
+{"abstract_id": "25205361", "label": "background", "text": "Our objective was to evaluate its efficacy on ADHD-like symptoms in neurofibromatosis type @ children ( @-@ years ) .", "sentence_id": 4}
+{"abstract_id": "25205361", "label": "methods", "text": "This was a randomised , double blind , placebo controlled , and crossover trial comparing @ to @ mg/kg/d of MPD as it is indicated for ADHD to placebo in NF@ children with ADHD-like symptoms .", "sentence_id": 5}
+{"abstract_id": "25205361", "label": "methods", "text": "Children aged @ to @years were eligible when their IQ was between @ and @ .", "sentence_id": 6}
+{"abstract_id": "25205361", "label": "methods", "text": "The total follow-up was @weeks including @weeks for each period and @week wash out .", "sentence_id": 7}
+{"abstract_id": "25205361", "label": "methods", "text": "Fifty subjects ( @ for each period ) were required for testing the primary study hypothesis .", "sentence_id": 8}
+{"abstract_id": "25205361", "label": "methods", "text": "The main outcome was an improvement in scores on the simplified Conners ' Parent Rating Scale .", "sentence_id": 9}
+{"abstract_id": "25205361", "label": "results", "text": "Thirty-nine patients were included between April @ and December @ .", "sentence_id": 10}
+{"abstract_id": "25205361", "label": "results", "text": "Twenty participants received MPD and @ placebo during the first period .", "sentence_id": 11}
+{"abstract_id": "25205361", "label": "results", "text": "They all completed the trial .", "sentence_id": 12}
+{"abstract_id": "25205361", "label": "results", "text": "MPD decreased the simplified Conners by @ points ( @ , p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25205361", "label": "conclusions", "text": "This is the first randomised controlled trial showing the short-term benefit of MPD on simplified Conners scores in NF@ children .", "sentence_id": 14}
+{"abstract_id": "24467672", "label": "background", "text": "Liver transection is considered a critical factor influencing intra-operative blood loss .", "sentence_id": 0}
+{"abstract_id": "24467672", "label": "background", "text": "A increase in the number of complex liver resections has determined a growing interest in new devices able to ` optimize ' the liver transection .", "sentence_id": 1}
+{"abstract_id": "24467672", "label": "background", "text": "The aim of this randomized controlled study was to compare a radiofrequency vessel-sealing system with the ` gold-standard ' clamp-crushing technique .", "sentence_id": 2}
+{"abstract_id": "24467672", "label": "methods", "text": "From January to December @ , @ consecutive patients undergoing a liver resection were randomized to the radiofrequency vessel-sealing system ( LF@ group ; N = @ ) or to the clamp-crushing technique ( Kelly group , N = @ ) .", "sentence_id": 3}
+{"abstract_id": "24467672", "label": "results", "text": "Background characteristics of the two groups were similar .", "sentence_id": 4}
+{"abstract_id": "24467672", "label": "results", "text": "There were not significant differences between the two groups in terms of blood loss , transection time and transection speed .", "sentence_id": 5}
+{"abstract_id": "24467672", "label": "results", "text": "In spite of a not-significant larger transection area in the LF@ group compared with the Kelly group ( @ versus @cm ( @ ) , P = @ ) , the overall and ` per cm ( @ ) ' blood losses were similar whereas the transection speed was better ( even if not significantly ) in the LF@ group compared with the Kelly group ( @ cm ( @ ) / min versus @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24467672", "label": "results", "text": "Mortality , morbidity and bile leak rates were similar in both groups .", "sentence_id": 7}
+{"abstract_id": "24467672", "label": "conclusions", "text": "The radiofrequency vessel-sealing system allows a quick and safe liver transection similar to the gold-standard clamp-crushing technique .", "sentence_id": 8}
+{"abstract_id": "24582019", "label": "background", "text": "Enamel demineralization and gingival inflammation are the most prevalent consequences of biofilm formation in orthodontics .", "sentence_id": 0}
+{"abstract_id": "24582019", "label": "background", "text": "Our hypothesis was that educating patients about the severe consequences of biofilm accumulation could enhance their oral hygiene while wearing fixed appliances .", "sentence_id": 1}
+{"abstract_id": "24582019", "label": "methods", "text": "This study was designed as a randomized controlled @-arm parallel trial .", "sentence_id": 2}
+{"abstract_id": "24582019", "label": "methods", "text": "A total of @ participants in Chengdu , China , matching the eligibility criteria of @ to @ years of age , at least @ natural teeth , and a treatment plan that included conventional stainless steel brackets , were randomly assigned to @ intervention groups based on computer-generated random sequencing using simple randomization without blocking .", "sentence_id": 3}
+{"abstract_id": "24582019", "label": "methods", "text": "In group A ( n = @ ) , the subjects were shown images illustrating the severe consequences of biofilm formation , including enamel demineralization and gingival inflammation ; subjects in group B ( n = @ ) were given biofilm disclosing tablets ; those in group C ( n = @ ) received a combination of A and B ; the subjects in group D ( n = @ ) served as the controls .", "sentence_id": 4}
+{"abstract_id": "24582019", "label": "methods", "text": "The investigators were blinded to the allocations , and the researcher managing the random sequence did not participate in allocation or measurement .", "sentence_id": 5}
+{"abstract_id": "24582019", "label": "methods", "text": "All groups received routine oral hygiene instructions .", "sentence_id": 6}
+{"abstract_id": "24582019", "label": "methods", "text": "Plaque index and gingival index scores were recorded at each appointment during a @-month follow-up .", "sentence_id": 7}
+{"abstract_id": "24582019", "label": "results", "text": "Eighteen participants were lost during follow-up , resulting in a total of @ participants after the trial ( group A , @ ; group B , @ ; group C , @ ; group D , @ ) .", "sentence_id": 8}
+{"abstract_id": "24582019", "label": "results", "text": "No adverse events were recorded .", "sentence_id": 9}
+{"abstract_id": "24582019", "label": "results", "text": "Groups A and C exhibited a significantly lower plaque index scores ( parameter-estimate -LSB- @ % confidence interval -RSB- = -@ -LSB- -@ to -@ -RSB- for group A , and -@ -LSB- -@ to -@ -RSB- for group C ) and gingival index scores ( -@ -LSB- -@ to -@ -RSB- , and -@ -LSB- -@ to -@ -RSB- ) , respectively , compared with group D ( P < @ for all ) , whereas no significant difference was found between groups B and D , or between groups A and C ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "24582019", "label": "results", "text": "The adults had significantly lower plaque index ( @ -LSB- @-@ @ -RSB- , P < @ ) and gingival index ( @ -LSB- @-@ @ -RSB- , P = @ ) scores than did the teenagers , and the female subjects had significantly higher gingival index ( -@ -LSB- -@ to -@ -RSB- , P = @ ) scores than did the male subjects .", "sentence_id": 11}
+{"abstract_id": "24582019", "label": "conclusions", "text": "The use of images showing the severe consequences of biofilm accumulation enhanced the oral hygiene of patients treated with fixed appliances .", "sentence_id": 12}
+{"abstract_id": "25307979", "label": "objective", "text": "The purpose of the study is to compare neuromuscular electrical stimulation ( NMES ) vs sham on leg strength at hospital discharge in mechanically ventilated patients .", "sentence_id": 0}
+{"abstract_id": "25307979", "label": "methods", "text": "We conducted a randomized pilot study of NMES vs sham applied to @ bilateral lower extremity muscle groups for @ minutes daily in the intensive care unit ( ICU ) .", "sentence_id": 1}
+{"abstract_id": "25307979", "label": "methods", "text": "Between June @ and March @ , we enrolled adults who were receiving mechanical ventilation within the first week of ICU stay and who could transfer independently from bed to chair before hospital admission .", "sentence_id": 2}
+{"abstract_id": "25307979", "label": "methods", "text": "The primary outcome was lower extremity muscle strength at hospital discharge using Medical Research Council score ( maximum , @ ) .", "sentence_id": 3}
+{"abstract_id": "25307979", "label": "methods", "text": "Secondary outcomes at hospital discharge included walking distance and change in lower extremity strength from ICU awakening .", "sentence_id": 4}
+{"abstract_id": "25307979", "label": "methods", "text": "Clinicaltrials.gov : NCT@ .", "sentence_id": 5}
+{"abstract_id": "25307979", "label": "results", "text": "We stopped enrollment early after @ patients due to slow patient accrual and the end of research funding .", "sentence_id": 6}
+{"abstract_id": "25307979", "label": "results", "text": "For NMES vs sham , mean ( SD ) lower extremity strength was @ ( @ ) vs @ ( @ ) , P = @ .", "sentence_id": 7}
+{"abstract_id": "25307979", "label": "results", "text": "Among secondary outcomes , NMES vs sham patients had a greater mean ( SD ) walking distance ( @ -LSB- @ -RSB- vs @ -LSB- @ -RSB- ft , P = @ ) and increase in muscle strength ( @ -LSB- @ -RSB- vs @ -LSB- @ -RSB- , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25307979", "label": "conclusions", "text": "In this pilot randomized trial , NMES did not significantly improve leg strength at hospital discharge .", "sentence_id": 9}
+{"abstract_id": "25307979", "label": "conclusions", "text": "Significant improvements in secondary outcomes require investigation in future research .", "sentence_id": 10}
+{"abstract_id": "24721240", "label": "objective", "text": "To prospectively evaluate the efficacy of a traditional Chinese medicine ( TCM ) - based therapy for treating liver fibrosis in patients with chronic hepatitis B ( CHB ) , and to investigate the patients ' perception of the treatment 's effects on quality of life ( QoL ) .", "sentence_id": 0}
+{"abstract_id": "24721240", "label": "methods", "text": "A total of @ patients with CHB-related liver fibrosis were randomly assigned to treatment groups for receipt of a @-month course of the antiviral drug entecavir alone ( control group ) or in combination with the TCM Liuweiwuling tablets .", "sentence_id": 1}
+{"abstract_id": "24721240", "label": "methods", "text": "Patients were assessed before ( pre-treatment ) and after therapy and the treatment-related differences in clinical manifestations , levels of liver function markers and liver fibrosis indexes , color ultrasound images , and hepatitis B virus ( HBV ) DNA load were compared between the two groups by statistical analysis .", "sentence_id": 2}
+{"abstract_id": "24721240", "label": "methods", "text": "The generic QoL scale developed by the World Health Organization ( WHOQOL-BREF ) was used to score the patients ' perceptions of treatment outcome .", "sentence_id": 3}
+{"abstract_id": "24721240", "label": "results", "text": "After treatment , the patients in both groups showed significant improvement in the majority of clinical manifestations ( both P less than @ ) , with the exception of bloating .", "sentence_id": 4}
+{"abstract_id": "24721240", "label": "results", "text": "In addition , both groups showed significant improvements of liver function markers and in signs of liver fibrosis ( both P less than @ ) .", "sentence_id": 5}
+{"abstract_id": "24721240", "label": "results", "text": "Both groups also showed significant reductions in the diameters of the portal and splenic ( both P less than @ ) , as well as increases in the rate of undetectable HBV DNA ( with a statistically similar outcome achieved in the two groups ) .", "sentence_id": 6}
+{"abstract_id": "24721240", "label": "results", "text": "Finally , both groups had higher QoL scores after treatment , with all assessed parameters except environment showing a significant improvement ( all P less than @ ) .", "sentence_id": 7}
+{"abstract_id": "24721240", "label": "conclusions", "text": "When used in combination with entecavir , the TCM Liuweiwuling tablet is a safe therapy for CHB and its related liver fibrosis and may help to improve the QoL of these patients .", "sentence_id": 8}
+{"abstract_id": "25425308", "label": "objective", "text": "Progressive decline of psychophysical cone-mediated measures has been reported in type @ ( USH@ ) and type @ ( USH@ ) Usher syndrome .", "sentence_id": 0}
+{"abstract_id": "25425308", "label": "objective", "text": "Conventional cone electroretinogram ( ERG ) responses in USH demonstrate poor signal-to-noise ratio .", "sentence_id": 1}
+{"abstract_id": "25425308", "label": "objective", "text": "We evaluated cone signals in USH@ and USH@ by recording microvolt level cycle-by-cycle ( CxC ) ERG .", "sentence_id": 2}
+{"abstract_id": "25425308", "label": "methods", "text": "Responses of molecularly genotyped USH@ ( n = @ ) and USH@ ( n = @ ) subjects ( age range , @-@ years ) were compared with those of controls ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25425308", "label": "methods", "text": "A subset of USH@ ( n = @ ) and USH@ ( n = @ ) subjects was examined two to four times over @ to @ years .", "sentence_id": 4}
+{"abstract_id": "25425308", "label": "methods", "text": "Photopic CxC ERG and conventional @-Hz flicker ERG were recorded on the same visits .", "sentence_id": 5}
+{"abstract_id": "25425308", "label": "results", "text": "Usher syndrome subjects showed considerable cone flicker ERG amplitude losses and timing phase delays ( P < @ ) compared with controls .", "sentence_id": 6}
+{"abstract_id": "25425308", "label": "results", "text": "USH@ and USH@ had similar rates of progressive logarithmic ERG amplitude decline with disease duration ( -@ log V/y ) .", "sentence_id": 7}
+{"abstract_id": "25425308", "label": "results", "text": "Of interest , ERG phase delays did not progress over time .", "sentence_id": 8}
+{"abstract_id": "25425308", "label": "results", "text": "Two USH@C subjects retained normal response timing despite reduced amplitudes .", "sentence_id": 9}
+{"abstract_id": "25425308", "label": "results", "text": "The CxC ERG method provided reliable responses in all subjects , whereas conventional ERG was undetectable in @ of @ subjects .", "sentence_id": 10}
+{"abstract_id": "25425308", "label": "conclusions", "text": "Cycle-by-cycle ERG showed progressive loss of amplitude in both USH@ and USH@ subjects , comparable to that reported with psychophysical measures .", "sentence_id": 11}
+{"abstract_id": "25425308", "label": "conclusions", "text": "Usher subjects showed abnormal ERG response latency , but this changed less than amplitude with time .", "sentence_id": 12}
+{"abstract_id": "25425308", "label": "conclusions", "text": "In USH syndrome , CxC ERG is more sensitive than conventional ERG and warrants consideration as an outcome measure in USH treatment trials .", "sentence_id": 13}
+{"abstract_id": "25740265", "label": "objective", "text": "This study aimed to evaluate influence of ethnic factors on the pharmacokinetics of orally inhaled QMF@ , a novel combination of an approved longacting @-agonist , indacaterol ( Onbrez Breezhaler for COPD ) , and an approved inhaled corticosteroid , mometasone furoate ( MF ) , ( Asmanex Twisthaler for asthma ) , following multiple dose administration of QMF@ ( indacaterol acetate/MF ) @/@ g and @/@ g via the Breezhaler device in healthy Japanese and Caucasian subjects .", "sentence_id": 0}
+{"abstract_id": "25740265", "label": "methods", "text": "This was a single-center , openlabel , multiple-dose , two-period , complete crossover study that randomized healthy Japanese and , age and weight matched Caucasian subjects to QMF@ @/@ g or @/@ g once daily ( o.d. ) for @ days in each period .", "sentence_id": 1}
+{"abstract_id": "25740265", "label": "methods", "text": "Pharmacokinetics ( PK ) were assessed up to @ hours on days @ and @ .", "sentence_id": 2}
+{"abstract_id": "25740265", "label": "results", "text": "@ Japanese and @ Caucasian healthy subjects were enrolled .", "sentence_id": 3}
+{"abstract_id": "25740265", "label": "results", "text": "Indacaterol and MF had similar PK profiles across both the doses and both ethnic groups .", "sentence_id": 4}
+{"abstract_id": "25740265", "label": "results", "text": "The maximum geometric mean ratios ( @ % confidence interval ( CI ) ) for Japanese vs. Caucasian subjects for Cmax were @ ( @ - @ ) and @ ( @ - @ ) for indacaterol and MF , respectively .", "sentence_id": 5}
+{"abstract_id": "25740265", "label": "results", "text": "For AUC , the maximum ratios were @ ( @ - @ ) and @ ( @ - @ ) for indacaterol and MF , respectively .", "sentence_id": 6}
+{"abstract_id": "25740265", "label": "results", "text": "The mild trend towards higher exposure in Japanese subjects could be explained by the fact that the mean body weight was @ % higher for Caucasians compared to their Japanese counterparts .", "sentence_id": 7}
+{"abstract_id": "25740265", "label": "results", "text": "No serious adverse events or discontinuations related to study medication were reported .", "sentence_id": 8}
+{"abstract_id": "25740265", "label": "conclusions", "text": "The study demonstrated increase of mean exposure parameters in Japanese subjects vs. Caucasian subjects , which ranged between @ - @ % and @ - @ % , for indacaterol and MF components , respectively .", "sentence_id": 9}
+{"abstract_id": "25740265", "label": "conclusions", "text": "Multiple doses of both the QMF@ dose levels were safe and well-tolerated in all subjects .", "sentence_id": 10}
+{"abstract_id": "25740265", "label": "conclusions", "text": "Body weight was considered a key contributory factor for the observed difference in exposure .", "sentence_id": 11}
+{"abstract_id": "25740265", "label": "conclusions", "text": "These results suggest no dose adjustment for QMF@ is required in Asian populations .", "sentence_id": 12}
+{"abstract_id": "25455834", "label": "objective", "text": "The purpose of this study is to measure the prevalence of graded disc degeneration , spondylolisthesis , transitional segmentation , and the distribution of sacral slope in patients @ to @ years of age with chronic low back pain ( CLBP ) .", "sentence_id": 0}
+{"abstract_id": "25455834", "label": "methods", "text": "This retrospective study analyzed @ digital lumbar radiographic series obtained during a randomized controlled trial of chiropractic patients with CLBP .", "sentence_id": 1}
+{"abstract_id": "25455834", "label": "methods", "text": "Chronic low back pain was defined as pain in the low back lasting @ weeks or longer .", "sentence_id": 2}
+{"abstract_id": "25455834", "label": "methods", "text": "Radiographic findings of disc degeneration , spondylolisthesis , and lumbosacral transitional segmentation were graded by @ authors using established classification criteria .", "sentence_id": 3}
+{"abstract_id": "25455834", "label": "methods", "text": "Sacral slope was measured with a digital tool contained within imaging software .", "sentence_id": 4}
+{"abstract_id": "25455834", "label": "results", "text": "Lumbosacral transitional segments graded I to IV ( Castellvi classification ) were present in @ % of cases .", "sentence_id": 5}
+{"abstract_id": "25455834", "label": "results", "text": "Lumbar disc degeneration was most prevalent at L@-@ ( @ % ) , followed by L@-@ ( @ % ) , L@-@ ( @ % ) , L@-S@ ( @ % ) , and L@-@ ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25455834", "label": "results", "text": "Isthmic spondylolisthesis was present in @ % of cases , with L@ the most common location .", "sentence_id": 7}
+{"abstract_id": "25455834", "label": "results", "text": "Degenerative spondylolisthesis demonstrated a prevalence of @ % , most commonly occurring at L@ .", "sentence_id": 8}
+{"abstract_id": "25455834", "label": "results", "text": "The prevalence of degenerative spondylolisthesis was @ % for women aged @ to @ years and @ % for men in the same age range .", "sentence_id": 9}
+{"abstract_id": "25455834", "label": "conclusions", "text": "Moderate-severe disc degeneration , multilevel disc narrowing , and degenerative spondylolisthesis were common in individuals with CLBP with age more than @ years .", "sentence_id": 10}
+{"abstract_id": "25455834", "label": "conclusions", "text": "Isthmic spondylolisthesis was not more prevalent than what has been reported in other populations .", "sentence_id": 11}
+{"abstract_id": "25455834", "label": "conclusions", "text": "Transitional segmentation was identified in a minority of participants , with some of these exhibiting accessory joints or fusion .", "sentence_id": 12}
+{"abstract_id": "25455834", "label": "conclusions", "text": "Mean sacral slope in individuals with CLBP was not substantially different from mean slopes reported in other populations .", "sentence_id": 13}
+{"abstract_id": "25087835", "label": "objective", "text": "( @ ) Compare ideal cut-off points for DS and % FEV@ at @ and @hto predict hospitalization/relapse in subjects with moderate to severe asthma exacerbation ( @ ) Develop a multivariate regression model using DS , % FEV@ , demographic , and clinical variables to predict hospitalization/relapse .", "sentence_id": 0}
+{"abstract_id": "25087835", "label": "methods", "text": "Subjects with acute exacerbation of asthma ( FEV@ < @ % predicted following @minof standardized treatment : @mg nebulized albuterol ; @-@ @ mg nebulized ipratropium ; and @mg oral prednisone ) were eligible .", "sentence_id": 1}
+{"abstract_id": "25087835", "label": "methods", "text": "All subjects had % FEV@ and DS obtained at baseline and hourly for @h .", "sentence_id": 2}
+{"abstract_id": "25087835", "label": "methods", "text": "Using hospitalization/relapse as the outcome of interest ; we compared the area under the receiveroperator curves ( AUC ) between the @ and @hDS and % FEV@ measurements , and the AUC for the change in DS and % FEV@ between baseline and hour-@ .", "sentence_id": 3}
+{"abstract_id": "25087835", "label": "methods", "text": "We determined ideal cut-points for % FEV@ and DS to maximize sensitivity and specificity .", "sentence_id": 4}
+{"abstract_id": "25087835", "label": "methods", "text": "Sensitivity , specificity , positive and negative predictive values , and positive and negative likelihood ratios ( LR ) were compared between % FEV@ and DS .", "sentence_id": 5}
+{"abstract_id": "25087835", "label": "methods", "text": "We developed a multivariate regression model examining the association of specific demographic and clinical variables to hospitalization/relapse .", "sentence_id": 6}
+{"abstract_id": "25087835", "label": "results", "text": "@ patients were included for analysis .", "sentence_id": 7}
+{"abstract_id": "25087835", "label": "results", "text": "The AUC was greatest for the @-hDS ( @ ) , followed by the @-h % FEV@ ( @ ) .", "sentence_id": 8}
+{"abstract_id": "25087835", "label": "results", "text": "Optimum cut-off values were a DS of @ , and an FEV@ of @ % .", "sentence_id": 9}
+{"abstract_id": "25087835", "label": "results", "text": "These were associated with a + LR for the composite outcome of @ and @ respectively .", "sentence_id": 10}
+{"abstract_id": "25087835", "label": "results", "text": "Logistic regression showed baseline DS , @-hDS , change in DS , and oxygen use at hour @ were all associated with the composite outcome .", "sentence_id": 11}
+{"abstract_id": "25087835", "label": "conclusions", "text": "The @-hscore for % FEV@ and DS performed better than scores at any other time point and better than either parameter over time .", "sentence_id": 12}
+{"abstract_id": "25087835", "label": "conclusions", "text": "The @-hDS had the greatest association with the composite outcome .", "sentence_id": 13}
+{"abstract_id": "25087835", "label": "conclusions", "text": "Neither test was a strong enough predictor to be used solely for this purpose .", "sentence_id": 14}
+{"abstract_id": "24508922", "label": "background", "text": "Sarcopenia is currently best described as an age-related decline in skeletal muscle mass and function .", "sentence_id": 0}
+{"abstract_id": "24508922", "label": "background", "text": "However , no consensus exists as to how to best quantify muscle function in older adults .", "sentence_id": 1}
+{"abstract_id": "24508922", "label": "background", "text": "The muscle quality index ( MQI ) was recently recommended as an ideal evidence-based assessment of functional status in older adults .", "sentence_id": 2}
+{"abstract_id": "24508922", "label": "background", "text": "Nevertheless , the usefulness of MQI to assess physical function is limited by whether it is reflective of muscle qualitative changes to an intervention .", "sentence_id": 3}
+{"abstract_id": "24508922", "label": "background", "text": "Thus , the purpose of this investigation was to determine whether MQI changes in response to resistance exercise training and detraining and how such changes correspond to other recommended measures of physical function proposed by suggested definitions of sarcopenia .", "sentence_id": 4}
+{"abstract_id": "24508922", "label": "methods", "text": "Twenty-five older adults ( @ y ; BMI = @ kgm ( -@ ) ) completed a @-week resistance training program in a wait-list controlled , cross-over design .", "sentence_id": 5}
+{"abstract_id": "24508922", "label": "methods", "text": "MQI was determined as power output from timed sit to stand ( STS ) , body mass , and leg length .", "sentence_id": 6}
+{"abstract_id": "24508922", "label": "methods", "text": "Gait speed , hand grip strength , get-up-and-go and lean body mass ( LBM ) were evaluated before and after exercise training and detraining .", "sentence_id": 7}
+{"abstract_id": "24508922", "label": "methods", "text": "MQI and functional changes to training and detraining were evaluated with repeated measures ANOVA and clinical interpretations of magnitude based inferences .", "sentence_id": 8}
+{"abstract_id": "24508922", "label": "results", "text": "Short term resistance training significantly and clinically improved MQI ( @ to @ W ) , gait time ( @ to @ s ) and sit to stand performance ( @ to @ s ) .", "sentence_id": 9}
+{"abstract_id": "24508922", "label": "results", "text": "Changes in LBM and hand grip strength were not significant or clinically meaningful .", "sentence_id": 10}
+{"abstract_id": "24508922", "label": "results", "text": "De-training for @-weeks did not result in significant changes in any measure from post-training performance .", "sentence_id": 11}
+{"abstract_id": "24245738", "label": "background", "text": "The decreased number and senescence of circulating endothelial progenitor cells ( EPCs ) are considered markers of vascular senescence associated with aging , atherosclerosis , and coronary artery disease ( CAD ) in elderly .", "sentence_id": 0}
+{"abstract_id": "24245738", "label": "background", "text": "In this study , we explore the role of vascular senescence in premature CAD ( PCAD ) in a developing country by comparing the numerical status and senescence of circulating EPCs in PCAD patients to controls .", "sentence_id": 1}
+{"abstract_id": "24245738", "label": "methods", "text": "EPCs were measured by flow cytometry in @ patients with angiographically documented CAD , and @ controls without evidence of CAD , recruited from random patients @ years of age at All India Institute of Medical Sciences .", "sentence_id": 2}
+{"abstract_id": "24245738", "label": "methods", "text": "EPC senescence as determined by telomere length ( EPC-TL ) and telomerase activity ( EPC-TA ) was studied by real time polymerase chain reaction ( q PCR ) and PCR - ELISA respectively .", "sentence_id": 3}
+{"abstract_id": "24245738", "label": "results", "text": "The number of EPCs ( @ % Vs. @ % of total WBCs , p < @ ) , and EPC-TL ( @ Vs. @ kb/genome , p = @ ) were markedly lower in PCAD patients compared to controls .", "sentence_id": 4}
+{"abstract_id": "24245738", "label": "results", "text": "These differences persisted after adjustment for age , sex , BMI , smoking and medications .", "sentence_id": 5}
+{"abstract_id": "24245738", "label": "results", "text": "EPC-TA was reduced in PCAD patients , but was statistically significant only after adjustment for confounding factors ( @ Vs. @ IU/cell , unadjusted p = @ , adjusted p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24245738", "label": "conclusions", "text": "We observed an association between increased vascular cell senescence with PCAD in a sample of young patients from India .", "sentence_id": 7}
+{"abstract_id": "24245738", "label": "conclusions", "text": "This suggests that early accelerated vascular cell senescence may play an important mechanistic role in CAD epidemic in developing countries like India where PCAD burden is markedly higher compared to developed countries .", "sentence_id": 8}
+{"abstract_id": "25509730", "label": "objective", "text": "To compare the clinical efficacy differences between medicinal vesiculation combined with quick cupping at Shenque ( CV @ ) and regular medication for allergic rhinitis with syndrome of yang deficiency .", "sentence_id": 0}
+{"abstract_id": "25509730", "label": "methods", "text": "Eighty-two cases were randomly divided into an observation group ( @ cases ) and a control group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "25509730", "label": "methods", "text": "The observation group was treated with medicinal vesiculation combined with quick cupping at Shenque ( CV @ ) .", "sentence_id": 2}
+{"abstract_id": "25509730", "label": "methods", "text": "The medicinal vesiculation was applied at Feishu ( BL @ ) , Gaohuang ( BL @ ) , Fengmen ( BL @ ) , Mingmen ( GV @ ) on the dog days in the summer , one treatment on the @st dog-day , @nd dog-day and last dog-day respectively with an interval of @ days between two treatments .", "sentence_id": 3}
+{"abstract_id": "25509730", "label": "methods", "text": "Three treatments were taken as one course , and totally one course was given .", "sentence_id": 4}
+{"abstract_id": "25509730", "label": "methods", "text": "The quick cupping was applied at Shenque ( CV @ ) , once a day , ten treatments were taken as one course , and totally three courses was given .", "sentence_id": 5}
+{"abstract_id": "25509730", "label": "methods", "text": "The control group was treated with oral administration of loratadine and nasal spray of budesonide .", "sentence_id": 6}
+{"abstract_id": "25509730", "label": "methods", "text": "The loratadine was given @ mg per time , once a day for continuous @ days ; budesonide was given once a day , ten treatments were taken as one course , and totally three courses was given .", "sentence_id": 7}
+{"abstract_id": "25509730", "label": "methods", "text": "The clinical efficacy in two groups after treatment was observed , and the contents of immune globulin E ( IgE ) , interleukin-@ ( IL-@ ) , interleukin-@ ( IL-@ ) and tumor necrosis factor - ( TNF - ) in peripheral serum were measured before and after the treatments .", "sentence_id": 8}
+{"abstract_id": "25509730", "label": "results", "text": "Of all the @ patients , @ cases completed the treatment , and @ patient in the observation group and @ patients in the control group dropped out .", "sentence_id": 9}
+{"abstract_id": "25509730", "label": "results", "text": "The effective rate was @ % ( @/@ ) in the observation group , which was superior to @ % ( @/@ ) in the control group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25509730", "label": "results", "text": "After treatment , both groups effectively reduced the contents of IgE , IL-@ , IL-@ and TNF - , and the observation group had superior effect on reducing IgE and IL-@ to the control group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25509730", "label": "conclusions", "text": "The medicinal vesiculation combined with quick cupping at Shenque ( CV @ ) have better effect for allergic rhinitis with syndrome of yang deficiency than oral administration of loratadine and nasal spray of budesonide .", "sentence_id": 12}
+{"abstract_id": "24755125", "label": "objective", "text": "Tamsulosin and mirabegron may be used concomitantly in patients with lower urinary tract symptoms .", "sentence_id": 0}
+{"abstract_id": "24755125", "label": "objective", "text": "Since alpha@-adrenoceptor antagonists are associated with cardiovascular side effects , potential pharmacokinetic and cardiovascular interactions were evaluated .", "sentence_id": 1}
+{"abstract_id": "24755125", "label": "methods", "text": "This was an open-label , randomized , @-arm , @-sequence study in @ healthy men ( @/arm ) aged @ - @ years .", "sentence_id": 2}
+{"abstract_id": "24755125", "label": "methods", "text": "In arm @ , subjects received single-dose tamsulosin hydrochloride modified release capsules ( @ mg ) alone and with steady-state mirabegron oral controlled absorption system tablets ( @ mg once daily ) in random sequence .", "sentence_id": 3}
+{"abstract_id": "24755125", "label": "methods", "text": "In arm @ , subjects received single-dose mirabegron alone and with steady-state tamsulosin .", "sentence_id": 4}
+{"abstract_id": "24755125", "label": "methods", "text": "Samples for mirabegron and tamsulosin plasma concentrations were collected .", "sentence_id": 5}
+{"abstract_id": "24755125", "label": "methods", "text": "Blood pressure ( BP ) and pulse rate ( PR ) were measured and orthostatic stress tests were performed .", "sentence_id": 6}
+{"abstract_id": "24755125", "label": "results", "text": "Mirabegron increased tamsulosin C ( max ) to @ % ( @ % confidence interval ( CI ) @ - @ % ) , AUC ( ) to @ % ( @ % CI @ - @ % ) , and t ( @/@ ) to @ % .", "sentence_id": 7}
+{"abstract_id": "24755125", "label": "results", "text": "Tamsulosin reduced mirabegron C ( max ) to @ % ( @ % CI @ - @ % ) and AUC ( ) to @ % ( @ % CI @ - @ % ) without effect on t@/@ .", "sentence_id": 8}
+{"abstract_id": "24755125", "label": "results", "text": "Mirabegron and tamsulosin co-treatment caused no statistically significant changes ( p > @ ) in PR or systolic BP versus mono-treatment up to @ hours post-dose .", "sentence_id": 9}
+{"abstract_id": "24755125", "label": "results", "text": "Mean diastolic BP decreases of -@ ( @ % CI -@ , -@ ) to -@ ( -@ , -@ ) mmHg in arm @ and -@ ( -@ , -@ ) to -@ ( -@ , -@ ) mmHg in arm @ were observed , statistically significant ( p < @ ) at several time points , not accompanied by orthostatic symptoms or increases in positive orthostatic stress tests .", "sentence_id": 10}
+{"abstract_id": "24755125", "label": "results", "text": "Adverse and orthostatic events were balanced across treatments .", "sentence_id": 11}
+{"abstract_id": "24755125", "label": "conclusions", "text": "The observed pharmacokinetic interactions upon add-on of mirabegron or tamsulosin to existing tamsulosin or mirabegron therapy did not cause clinically relevant changes in cardiovascular safety or safety profiles .", "sentence_id": 12}
+{"abstract_id": "25145986", "label": "background", "text": "The efficacy of single-allergen-specific immunotherapy in polysensitized subjects is a matter of debate .", "sentence_id": 0}
+{"abstract_id": "25145986", "label": "background", "text": "This study aimed to investigate the efficacy of house dust mite ( HDM ) sublingual immunotherapy ( SLIT ) in monosensitized and polysensitized children .", "sentence_id": 1}
+{"abstract_id": "25145986", "label": "methods", "text": "A total of @ children , aged @ to @ years old , with HDM-induced respiratory allergic diseases were allocated to a monosensitized group ( n = @ ) or a polysensitized group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25145986", "label": "methods", "text": "Both groups were treated by standard pharmacotherapy and SLIT with Dermatophagoides farinae ( American HDM ) extracts for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25145986", "label": "methods", "text": "Symptoms , medications , visual analogue scale ( VAS ) , and presence of adverse events ( AEs ) were assessed once a month .", "sentence_id": 4}
+{"abstract_id": "25145986", "label": "methods", "text": "Skin-prick test ( SPT ) was done before and after treatment .", "sentence_id": 5}
+{"abstract_id": "25145986", "label": "methods", "text": "After treatment , subjects in the polysensitized group who completed the study were further analyzed as subgroup @ ( n = @ ) and subgroup @ ( n = @ ) according to the number of coexisting allergens .", "sentence_id": 6}
+{"abstract_id": "25145986", "label": "results", "text": "Forty-one subjects in the monosensitized group and @ subjects in the polysensitized group completed the study .", "sentence_id": 7}
+{"abstract_id": "25145986", "label": "results", "text": "The global clinical parameters had significantly improved after treatment , with no significant difference between the monosensitized and polysensitized group throughout this period ( all p > @ ) .", "sentence_id": 8}
+{"abstract_id": "25145986", "label": "results", "text": "The comparison among the monosensitized group , subgroup @ , and subgroup @ indicated that there was no significant difference in symptoms scores and VAS at each scheduled follow-up visit .", "sentence_id": 9}
+{"abstract_id": "25145986", "label": "results", "text": "There was also no significant difference in total medications score ( TMS ) in the monosensitized group , subgroup @ , and subgroup @ after week @ ( all p > @ ) .", "sentence_id": 10}
+{"abstract_id": "25145986", "label": "results", "text": "No severe systemic AEs were reported .", "sentence_id": 11}
+{"abstract_id": "25145986", "label": "conclusions", "text": "No significant difference was observed in the clinical effects of HDM SLIT between polysensitized and monosensitized children with respiratory allergic diseases .", "sentence_id": 12}
+{"abstract_id": "25213566", "label": "background", "text": "Obesity is associated with cardiometabolic disease , including insulin resistance ( IR ) and diabetes .", "sentence_id": 0}
+{"abstract_id": "25213566", "label": "background", "text": "Cyclic guanosine monophosphate ( cGMP ) signaling affects energy balance , IR , and glucose metabolism in experimental models .", "sentence_id": 1}
+{"abstract_id": "25213566", "label": "background", "text": "We sought to examine effects of phosphodiesterase-@ inhibition with tadalafil on IR in a pilot study of obese nondiabetic individuals .", "sentence_id": 2}
+{"abstract_id": "25213566", "label": "results", "text": "We conducted a randomized , double-blinded , placebo-controlled trial of adults age @ to @ years with obesity and elevated fasting insulin levels ( @ U/mL ) .", "sentence_id": 3}
+{"abstract_id": "25213566", "label": "results", "text": "Participants were randomized to tadalafil @ mg daily or placebo for @ months .", "sentence_id": 4}
+{"abstract_id": "25213566", "label": "results", "text": "Oral glucose tolerance tests were performed , and the effect of tadalafil on IR was examined .", "sentence_id": 5}
+{"abstract_id": "25213566", "label": "results", "text": "A total of @ participants ( mean age , @ years ; body mass index -LSB- BMI -RSB- , @ kg/m ( @ ) ) were analyzed , @ randomized to tadalafil and @ to placebo .", "sentence_id": 6}
+{"abstract_id": "25213566", "label": "results", "text": "In the overall sample , measures of IR did not differ between tadalafil and placebo groups at @ months .", "sentence_id": 7}
+{"abstract_id": "25213566", "label": "results", "text": "However , in individuals with severe obesity ( BMI @ kg/m ( @ ) ) , tadalafil use was associated with improved IR ( homeostatic model assessment for IR ) , compared to placebo ( P = @ , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25213566", "label": "results", "text": "Furthermore , one measure of - cell compensation for IR ( oral disposition index ) improved with tadalafil in the overall sample ( P = @ ) and in the subgroup with severe obesity ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25213566", "label": "conclusions", "text": "Results of this pilot study did not show improvements in IR with tadalafil , compared to placebo .", "sentence_id": 10}
+{"abstract_id": "25213566", "label": "conclusions", "text": "However , tadalafil may have favorable effects on - cell compensation , particularly in individuals with severe obesity .", "sentence_id": 11}
+{"abstract_id": "25213566", "label": "conclusions", "text": "Future studies evaluating the potential metabolic benefits of cGMP modulation in obesity are warranted .", "sentence_id": 12}
+{"abstract_id": "25031315", "label": "background", "text": "Inpatient medical settings offer an opportunistic environment for initiating smoking cessation interventions to patients reflecting on their health .", "sentence_id": 0}
+{"abstract_id": "25031315", "label": "background", "text": "Current evidence has shown the superior efficacy of varenicline tartrate ( VT ) for smoking cessation compared with other tobacco cessation therapies ; however , recent evidence also has highlighted concerns about the safety and tolerability of VT. .", "sentence_id": 1}
+{"abstract_id": "25031315", "label": "background", "text": "Given these apprehensions , we aimed to evaluate the safety and effectiveness of VT plus quitline-counseling compared to quitline-counseling alone in the inpatient medical setting .", "sentence_id": 2}
+{"abstract_id": "25031315", "label": "methods", "text": "Adult patients ( n = @ , @-@ years ) admitted with a smoking-related illnesses to @ hospitals were randomized to receive either @ weeks of varenicline tartrate ( titrated from @ mg daily to @mg twice daily ) plus quitline-counseling ( VT+C ) , ( n = @ ) or quitline-counseling alone ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25031315", "label": "results", "text": "VT was well tolerated in the inpatient setting among subjects admitted with acute smoking-related illnesses ( mean age @ and @ years in the VT+C and counseling alone groups , respectively ) .", "sentence_id": 4}
+{"abstract_id": "25031315", "label": "results", "text": "The most common self-reported adverse event during the @-week treatment phase was nausea ( @ % in the VT+C group compared with @ % in the counseling alone group ) .", "sentence_id": 5}
+{"abstract_id": "25031315", "label": "results", "text": "Thirteen deaths occurred during the study period ( n = @ were in the VT+C arm compared with n = @ in the counseling alone arm ) .", "sentence_id": 6}
+{"abstract_id": "25031315", "label": "results", "text": "All of these subjects had known comorbidities or developed underlying comorbidities .", "sentence_id": 7}
+{"abstract_id": "25031315", "label": "conclusions", "text": "VT appears to be a safe and well-tolerated opportunistic treatment for inpatient smokers who have related chronic disease .", "sentence_id": 8}
+{"abstract_id": "25031315", "label": "conclusions", "text": "Based on the proven efficacy of varenicline from outpatient studies and our recent inpatient evidence , we suggest it be considered as part of standard care in the hospital setting .", "sentence_id": 9}
+{"abstract_id": "25010883", "label": "objective", "text": "Although the VITA @D-Master ( @D ) shade guide offers improved shade-matching performance , many dental materials are only available in VITA Classical ( VC ) shades .", "sentence_id": 0}
+{"abstract_id": "25010883", "label": "objective", "text": "This study aimed to clarify whether it is possible to convert @D shades determined by observers into VC shades ( indirect method ) without adding a clinically significant error in comparison with direct shade determination using the VC shade guide .", "sentence_id": 1}
+{"abstract_id": "25010883", "label": "methods", "text": "Forty ceramic specimens were fabricated .", "sentence_id": 2}
+{"abstract_id": "25010883", "label": "methods", "text": "L * a * b * values were recorded using a spectroradiometer .", "sentence_id": 3}
+{"abstract_id": "25010883", "label": "methods", "text": "Sixty participants ( @ dentists , @ technicians , and @ students ) were recruited and asked to determine the shades of specimens using the VC and @D shade guides under standardized conditions .", "sentence_id": 4}
+{"abstract_id": "25010883", "label": "methods", "text": "Conversion tables were constructed by allocating the closest VC shade tab to every matched @D shade and by use of an optimization algorithm ( indirect methods ) .", "sentence_id": 5}
+{"abstract_id": "25010883", "label": "methods", "text": "Differences between E values for VC matches and for the indirect methods were evaluated using t tests .", "sentence_id": 6}
+{"abstract_id": "25010883", "label": "results", "text": "A mean E ( SD ) of @ ( @ ) for VC and @ ( @ ) for @D was observed ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25010883", "label": "results", "text": "Compared with direct shade matching using VC , the indirect method with the optimized tables resulted in a mean E of @ ( @ ) , which was not significantly different ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25010883", "label": "conclusions", "text": "Within the limitations of this study , the conversion tables were suitable for the determination of tooth color using the @D shade guide followed by conversion into VC shades without adding a clinically significant error .", "sentence_id": 9}
+{"abstract_id": "24498875", "label": "background", "text": "It has been well documented that the maturing oocyte is very vulnerable to changes in its micro-environment , the follicular fluid ( FF ) .", "sentence_id": 0}
+{"abstract_id": "24498875", "label": "background", "text": "Recent research has focused on different components within this FF , like hormones , growth factors and metabolites , and how their concentrations are altered by diet and the metabolic health of the mother .", "sentence_id": 1}
+{"abstract_id": "24498875", "label": "background", "text": "It has been proposed that fatty acids ( FAs ) are potential factors that influence oocyte maturation and subsequent embryo development .", "sentence_id": 2}
+{"abstract_id": "24498875", "label": "background", "text": "However , a thorough study of the specific FF FA composition per lipid fraction and how this may be affected by BMI is currently lacking .", "sentence_id": 3}
+{"abstract_id": "24498875", "label": "background", "text": "Therefore , we investigated the BMI-related concentration of FAs in the phospholipid ( PL ) , cholesteryl-ester ( CHE ) , triglyceride ( TG ) and non-esterified ( NE ) lipid fraction in the FF of women undergoing assisted reproductive treatment ( ART ) .", "sentence_id": 4}
+{"abstract_id": "24498875", "label": "methods", "text": "In this descriptive cross-sectional study , the FF of normal weight ( @ BMI < @ kg/m ( @ ) , n = @ ) , overweight ( @ BMI < @ kg/m ( @ ) , n = @ ) and obese ( BMI@ @ kg/m ( @ ) , n = @ ) women , undergoing ART , was sampled and analyzed for @ specific FAs in the PL , CHE , TG and NEFA fraction , using a gas chromatographic analysis method .", "sentence_id": 5}
+{"abstract_id": "24498875", "label": "methods", "text": "Differences between BMI-groups were studied by means of univariate general linear models and post hoc Sheff tests .", "sentence_id": 6}
+{"abstract_id": "24498875", "label": "results", "text": "Total FA concentrations in the PL and CHE fraction did not differ between BMI groups .", "sentence_id": 7}
+{"abstract_id": "24498875", "label": "results", "text": "Total TG concentrations tended to differ and total NEFA concentrations differed significantly between BMI groups .", "sentence_id": 8}
+{"abstract_id": "24498875", "label": "results", "text": "Interestingly , @ % and @ % of the total FAs was esterified in the PL and CHE fraction , respectively , while only @ % were present in both the TG and NEFA fraction .", "sentence_id": 9}
+{"abstract_id": "24498875", "label": "results", "text": "Only few individual FA concentrations differed in the PL , CHE and TG fraction between BMI groups , whereas abundant BMI-related differences were found in the NEFA fraction .", "sentence_id": 10}
+{"abstract_id": "24498875", "label": "conclusions", "text": "Our data show that differences in BMI are associated with alterations in the FA composition of the FF , an effect most pronounced in the NEFA fraction .", "sentence_id": 11}
+{"abstract_id": "24498875", "label": "conclusions", "text": "These BMI-related variations could possibly affect granulosa cell viability , oocyte developmental competence and subsequent embryo quality possibly explaining differences in oocyte quality in obese patients described by others .", "sentence_id": 12}
+{"abstract_id": "24283282", "label": "objective", "text": "To compare three children 's sodium fluoride toothpastes to placebo with respect to enamel remineralisation potential , enamel fluoride uptake and net acid resistance using an in situ palatal caries model in children aged @-@ years following a single brushing .", "sentence_id": 0}
+{"abstract_id": "24283282", "label": "methods", "text": "This was a randomised , single blind ( laboratory analyst ) , single-centre , four-treatment , crossover study with a @-day washout period between treatments .", "sentence_id": 1}
+{"abstract_id": "24283282", "label": "methods", "text": "The treatments were @,@ ppm fluoride , @,@ ppm fluoride , @ ppm fluoride and @ ppm fluoride ( placebo ) toothpaste ( NaF/silica ) .", "sentence_id": 2}
+{"abstract_id": "24283282", "label": "methods", "text": "A custom made in situ palatal appliance was used by each subject in all treatment periods .", "sentence_id": 3}
+{"abstract_id": "24283282", "label": "methods", "text": "At each of the four treatment visits subjects wore the appliance containing four partially demineralised human enamel specimens for @ minutes and then brushed their teeth using a standardised procedure for @ seconds under supervision using @ g ( @ g ) of their assigned toothpaste .", "sentence_id": 4}
+{"abstract_id": "24283282", "label": "methods", "text": "After @ hours the appliance was removed and enamel specimen recovered .", "sentence_id": 5}
+{"abstract_id": "24283282", "label": "methods", "text": "This process was repeated until all subjects completed all four study treatment visits .", "sentence_id": 6}
+{"abstract_id": "24283282", "label": "methods", "text": "Recovered enamel specimens were analysed for per cent surface microhardness recovery ( % SMHR ; Knoop ) and enamel fluoride uptake ( EFU ; microdrill biopsy ) .", "sentence_id": 7}
+{"abstract_id": "24283282", "label": "methods", "text": "Subsequently , specimens were demineralised in vitro to determine their % net acid resistance ( % NAR ; Knoop ) .", "sentence_id": 8}
+{"abstract_id": "24283282", "label": "results", "text": "All three fluoride toothpastes demonstrated significantly greater % SMHR , EFU and % NAR compared with @ ppm F toothpaste .", "sentence_id": 9}
+{"abstract_id": "24283282", "label": "results", "text": "The model demonstrated a dose response over the range @ to @,@ ppm fluoride for % SMHR , EFU and % NAR .", "sentence_id": 10}
+{"abstract_id": "24283282", "label": "results", "text": "There was no significant difference between @ ppm F and @,@ ppm F for % SMHR and between @,@ ppm F and @,@ ppm F for % SMHR , EFU and % NAR .", "sentence_id": 11}
+{"abstract_id": "24283282", "label": "conclusions", "text": "The present in situ study demonstrated that the children 's fluoride toothpastes tested are capable of delivering cariostatic amounts of fluoride to early caries lesions following a single brushing .", "sentence_id": 12}
+{"abstract_id": "24281004", "label": "background", "text": "This randomised phase II trial compared dose-escalated weekly paclitaxel ( wPTX ) vs standard-dose wPTX for patients with previously treated advanced gastric cancer ( AGC ) .", "sentence_id": 0}
+{"abstract_id": "24281004", "label": "methods", "text": "Ninety patients were randomised to a standard dose of wPTX ( @mgm ( -@ ) ) or an escalated dose of wPTX ( @-@mgm ( -@ ) ) to assess the superiority of overall survival ( OS ) with a one-sided alpha error of @ and a power of @ .", "sentence_id": 1}
+{"abstract_id": "24281004", "label": "results", "text": "The median OS showed a trend towards longer survival in the dose-escalated arm ( @ vs @ months ; hazard ratio ( HR ) , @ ; one-sided P = @ ) , although it was statistically not significant .", "sentence_id": 2}
+{"abstract_id": "24281004", "label": "results", "text": "The median progression-free survival ( PFS ) was significantly longer in the dose-escalated arm ( @ vs @ months , HR , @ ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24281004", "label": "results", "text": "Objective response rate was @ % with dose escalation and @ % with standard dose ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24281004", "label": "results", "text": "The frequency of all grades of neutropenia was significantly higher with dose escalation ( @ % vs @ % , P = @ ) ; however , no significant difference was observed in the proportion of patients experiencing grade @ or more ( @ % vs @ % , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24281004", "label": "conclusions", "text": "Dose-escalated wPTX in patients with pretreated AGC met our predefined threshold of primary end point , OS ( P < @ ) ; however , it did not show a significantly longer OS .", "sentence_id": 6}
+{"abstract_id": "24281004", "label": "conclusions", "text": "Progression-free survival was significantly better with dose escalation .", "sentence_id": 7}
+{"abstract_id": "25833983", "label": "background", "text": "Abdominal obesity and exaggerated postprandial lipemia are independent risk factors for cardiovascular disease ( CVD ) and mortality , and both are affected by dietary behavior .", "sentence_id": 0}
+{"abstract_id": "25833983", "label": "objective", "text": "We investigated whether dietary supplementation with whey protein and medium-chain saturated fatty acids ( MC-SFAs ) improved postprandial lipid metabolism in humans with abdominal obesity .", "sentence_id": 1}
+{"abstract_id": "25833983", "label": "methods", "text": "We conducted a @-wk , randomized , double-blinded , diet intervention study .", "sentence_id": 2}
+{"abstract_id": "25833983", "label": "methods", "text": "Sixty-three adults were randomly allocated to one of @ diets in a @ @ factorial design .", "sentence_id": 3}
+{"abstract_id": "25833983", "label": "methods", "text": "Participants consumed @ g milk protein ( whey or casein ) and @ g milk fat ( with high or low MC-SFA content ) daily .", "sentence_id": 4}
+{"abstract_id": "25833983", "label": "methods", "text": "Before and after the intervention , a high-fat meal test was performed .", "sentence_id": 5}
+{"abstract_id": "25833983", "label": "methods", "text": "We measured changes from baseline in fasting and postprandial triacylglycerol , apolipoprotein B-@ ( apoB-@ ; reflecting chylomicrons of intestinal origin ) , free fatty acids ( FFAs ) , insulin , glucose , glucagon , glucagon-like peptide @ ( GLP-@ ) , and gastric inhibitory polypeptide ( GIP ) .", "sentence_id": 6}
+{"abstract_id": "25833983", "label": "methods", "text": "Furthermore , changes in the expression of adipose tissue genes involved in lipid metabolism were investigated .", "sentence_id": 7}
+{"abstract_id": "25833983", "label": "methods", "text": "Two-factor ANOVA was used to examine the difference between protein types and fatty acid compositions , as well as any interaction between the two .", "sentence_id": 8}
+{"abstract_id": "25833983", "label": "results", "text": "Fifty-two participants completed the study .", "sentence_id": 9}
+{"abstract_id": "25833983", "label": "results", "text": "We found that the postprandial apoB-@ response decreased significantly after whey compared with casein ( P = @ ) independently of fatty acid composition .", "sentence_id": 10}
+{"abstract_id": "25833983", "label": "results", "text": "Furthermore , supplementation with casein resulted in a significant increase in the postprandial GLP-@ response compared with whey ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25833983", "label": "results", "text": "We found no difference in postprandial triacylglycerol , FFA , insulin , glucose , glucagon , or GIP related to protein type or MC-SFA content .", "sentence_id": 12}
+{"abstract_id": "25833983", "label": "results", "text": "We observed no interaction between milk protein and milk fat on postprandial lipemia .", "sentence_id": 13}
+{"abstract_id": "25833983", "label": "conclusions", "text": "We found that a whey protein supplement decreased the postprandial chylomicron response compared with casein in persons with abdominal obesity , thereby indicating a beneficial impact on CVD risk .", "sentence_id": 14}
+{"abstract_id": "25833983", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 15}
+{"abstract_id": "25342896", "label": "background", "text": "Aging involves a progressive reduction of respiratory muscle strength as well as muscle strength .", "sentence_id": 0}
+{"abstract_id": "25342896", "label": "objective", "text": "Compare the effects of resistance training volume on the maximum inspiratory pressure ( MIP ) , maximum expiratory pressure ( MEP ) , functional performance , and muscle strength in elderly women .", "sentence_id": 1}
+{"abstract_id": "25342896", "label": "methods", "text": "Thirty elderly women were randomly assigned to a group performing either single sets ( @-SET ) or three sets ( @-SET ) of exercises .", "sentence_id": 2}
+{"abstract_id": "25342896", "label": "methods", "text": "The sit-to-stand test , MIP , MEP , and muscle strength were assessed before and after @ training sessions .", "sentence_id": 3}
+{"abstract_id": "25342896", "label": "methods", "text": "Progressive resistance training was performed two times per week for a total of @-@ repetitions , using the main muscle groups of the upper and lower limbs .", "sentence_id": 4}
+{"abstract_id": "25342896", "label": "results", "text": "The main results showed that the participants significantly increased their MEP ( P < @ ; @-SET : @ % ; @-SET : @ % ) and MIP ( P < @ ; @-SET : @ % ; @-SET : @ % ) .", "sentence_id": 5}
+{"abstract_id": "25342896", "label": "results", "text": "Both groups also improved in the sit-to-stand test ( P < @ ; @-SET : @ % ; @-SET : @ % ) .", "sentence_id": 6}
+{"abstract_id": "25342896", "label": "results", "text": "After @ training sessions , muscle strength also significantly increased ( P < @ ; @ % -@ % ) in both groups .", "sentence_id": 7}
+{"abstract_id": "25342896", "label": "results", "text": "An intergroup comparison did not show any statistically significant differences between the groups in any of the parameters analyzed .", "sentence_id": 8}
+{"abstract_id": "25342896", "label": "conclusions", "text": "Single - and multiple-set resistance training programs increased MIP , MEP , muscle strength , and sit-to-stand test performance in elderly women after @ sessions of training .", "sentence_id": 9}
+{"abstract_id": "25342896", "label": "conclusions", "text": "In conclusion , our results suggested that elderly women who are not in the habit of physical activity may start with single-set resistance training programs as a short-term strategy for the maintenance of health .", "sentence_id": 10}
+{"abstract_id": "25724455", "label": "objective", "text": "Infliximab , a tumor necrosis factor antagonist , is effective for treating patients with Crohn 's disease ( CD ) and ulcerative colitis ( UC ) .", "sentence_id": 0}
+{"abstract_id": "25724455", "label": "objective", "text": "We aimed to determine whether dosing based on therapeutic drug monitoring increases rate of remission and whether continued concentration-based dosing is superior to clinically based dosing of infliximab for maintaining remission in patients with CD and UC .", "sentence_id": 1}
+{"abstract_id": "25724455", "label": "methods", "text": "We performed a @-year randomized controlled trial at a tertiary referral center , including @ adults ( @ with CD and @ with UC ) with stable responses to maintenance infliximab therapy .", "sentence_id": 2}
+{"abstract_id": "25724455", "label": "methods", "text": "Doses were escalated or reduced using an algorithm to reach a target trough concentration ( TC ) of @-@ g/mL in all patients ( optimization phase ) .", "sentence_id": 3}
+{"abstract_id": "25724455", "label": "methods", "text": "Patients were randomly assigned ( @:@ ) to groups that received infliximab dosing based on their clinical features ( n = @ ) or continued dosing based on TCs ( n = @ ) ( maintenance phase ) .", "sentence_id": 4}
+{"abstract_id": "25724455", "label": "methods", "text": "The primary end point was clinical and biochemical remission at @ year after the optimization phase .", "sentence_id": 5}
+{"abstract_id": "25724455", "label": "results", "text": "At screening , @ of @ patients had a TC of infliximab of @-@ g/mL ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25724455", "label": "results", "text": "Of @ patients with TCs < @ g/mL , @ patients ( @ % ) achieved TCs of @-@ g/mL after dose escalation .", "sentence_id": 7}
+{"abstract_id": "25724455", "label": "results", "text": "This resulted in a higher proportion of CD patients in remission than before dose escalation ( @ % vs @ % ; P = @ ) and a decrease in the median concentration of C-reactive protein , compared with before the dose increase ( @ vs @ mg/L ; P < @ ) ; these changes were not observed in patients with UC .", "sentence_id": 8}
+{"abstract_id": "25724455", "label": "results", "text": "Of @ patients with TCs > @ g/mL , @ patients ( @ % ) achieved TCs of @-@ g/mL after dose reduction .", "sentence_id": 9}
+{"abstract_id": "25724455", "label": "results", "text": "This resulted in a @ % reduction in drug cost from before dose reduction ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25724455", "label": "results", "text": "Sixty-six percent of patients whose dosing was based on clinical features and @ % whose dosing was based on TC achieved remission , the primary end point ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25724455", "label": "results", "text": "Disease relapsed in @ patients who received clinically based dosing ( @ % ) and @ patients who received concentration-based dosing ( @ % ) ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25724455", "label": "conclusions", "text": "Targeting patients ' infliximab TCs to @-@ g/mL results in a more efficient use of the drug .", "sentence_id": 13}
+{"abstract_id": "25724455", "label": "conclusions", "text": "After dose optimization , continued concentration-based dosing was not superior to clinically based dosing for achieving remission after @ year , but was associated with fewer flares during the course of treatment .", "sentence_id": 14}
+{"abstract_id": "25724455", "label": "conclusions", "text": "ClinicalTrialsRegister.eu number : @-@-@ .", "sentence_id": 15}
+{"abstract_id": "24314835", "label": "objective", "text": "To determine if volunteers can simulate and reproduce @ types of neurologic field defects : hemianopia , quadrantanopia , and central scotoma .", "sentence_id": 0}
+{"abstract_id": "24314835", "label": "methods", "text": "Cross-sectional study .", "sentence_id": 1}
+{"abstract_id": "24314835", "label": "methods", "text": "Thirty healthy volunteers new to perimetry ( including automated perimetry ) .", "sentence_id": 2}
+{"abstract_id": "24314835", "label": "methods", "text": "After informed consent , volunteers were randomized to @ of the @ visual field defects listed above .", "sentence_id": 3}
+{"abstract_id": "24314835", "label": "methods", "text": "All visual field testing was performed on the right eye using the Humphrey Field Analyzer ( HFA ; Carl Zeiss Meditec , Dublin , CA ) SITA Fast @-@ protocol .", "sentence_id": 4}
+{"abstract_id": "24314835", "label": "methods", "text": "Each volunteer was provided with standard new patient instructions and was shown a diagram of the defect to be simulated .", "sentence_id": 5}
+{"abstract_id": "24314835", "label": "methods", "text": "Two sets of visual fields were performed on the right eye with @ minutes between tests .", "sentence_id": 6}
+{"abstract_id": "24314835", "label": "methods", "text": "Three experts used the Ocular Hypertension Treatment Study reading center criteria and determined if the simulation was successful .", "sentence_id": 7}
+{"abstract_id": "24314835", "label": "methods", "text": "Proportion of volunteers able to simulate the assigned visual field .", "sentence_id": 8}
+{"abstract_id": "24314835", "label": "results", "text": "All @ volunteers ( @ % ) successfully simulated a hemianopia on the first and second fields .", "sentence_id": 9}
+{"abstract_id": "24314835", "label": "results", "text": "All @ volunteers ( @ % ) simulated a quadrantanopia on the first field and @ ( @ % ) did so on the second field .", "sentence_id": 10}
+{"abstract_id": "24314835", "label": "results", "text": "Eight volunteers ( @ % ) successfully simulated a central scotoma in the first field and all @ ( @ % ) did so on in the second field .", "sentence_id": 11}
+{"abstract_id": "24314835", "label": "results", "text": "Reliability criteria were excellent .", "sentence_id": 12}
+{"abstract_id": "24314835", "label": "results", "text": "Forty-seven fields ( @ % ) had @ fixation losses , @ ( @ % ) had @ false-positive results , and @ ( @ % ) had @ false-negative results .", "sentence_id": 13}
+{"abstract_id": "24314835", "label": "conclusions", "text": "It is easy to simulate reproducible and reliable neurologic field defects on automated perimetry using HFA .", "sentence_id": 14}
+{"abstract_id": "24525630", "label": "background", "text": "The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block ( SMB ) for postoperative pain relief in infants undergoing cleft palate repair .", "sentence_id": 0}
+{"abstract_id": "24525630", "label": "methods", "text": "In this prospective , double-blind , single-site , randomized , and parallel-arm controlled trial , @ children were assigned to undergo bilateral SMB with general anesthesia with either @ ml/kg of @ % ropivacaine ( Ropi group ) or @ ml/kg of isotonic saline ( Saline group ) on each side .", "sentence_id": 1}
+{"abstract_id": "24525630", "label": "methods", "text": "The primary endpoint was total postoperative morphine consumption at @ h. Pain scores and respiratory - and SMB-related complications were noted .", "sentence_id": 2}
+{"abstract_id": "24525630", "label": "results", "text": "The overall dose of intravenous morphine after @ h ( mean -LSB- @ % CI -RSB- ) was lower in the Ropi group compared with that in the Saline group ( @ -LSB- @ to @ -RSB- vs. @ -LSB- @ to @ -RSB- g/kg ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24525630", "label": "results", "text": "Continuous morphine infusion was less frequent in the Ropi group compared with that in the Saline group ( @ patient -LSB- @ % -RSB- vs. @ patients -LSB- @ % -RSB- ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24525630", "label": "results", "text": "Three patients in the Saline group had an episode of oxygen desaturation requiring oxygen therapy .", "sentence_id": 5}
+{"abstract_id": "24525630", "label": "results", "text": "There were no technical failures or immediate complications of the SMB .", "sentence_id": 6}
+{"abstract_id": "24525630", "label": "results", "text": "Intraoperative hemodynamic parameters , doses of sufentanil , pain scores , and postoperative hydroxyzine requirements were not different between the two groups .", "sentence_id": 7}
+{"abstract_id": "24525630", "label": "conclusions", "text": "Bilateral SMB is an easy regional anesthesia technique that reduces total morphine consumption at @ h after cleft palate repair in children and the use of continuous infusion of morphine and may decrease postoperative respiratory complications .", "sentence_id": 8}
+{"abstract_id": "25355310", "label": "objective", "text": "To evaluate the efficacy and safety of AVP-@ , a drug-device combination of low-dose sumatriptan powder ( @mg loaded dose ) delivered intranasally through a targeted Breath Powered device vs an identical device containing lactose powder ( placebo device ) in the treatment of migraine headache .", "sentence_id": 0}
+{"abstract_id": "25355310", "label": "background", "text": "Early treatment of migraine headaches is associated with improved outcome , but medication absorption after oral delivery may be delayed in migraineurs because of reduced gastric motility .", "sentence_id": 1}
+{"abstract_id": "25355310", "label": "background", "text": "Sumatriptan powder administered with an innovative , closed-palate , Bi-Directional , Breath Powered intranasal delivery mechanism is efficiently absorbed across the nasal mucosa and produces fast absorption into the circulation .", "sentence_id": 2}
+{"abstract_id": "25355310", "label": "background", "text": "Results from a previously conducted placebo-controlled study of AVP-@ showed a high degree of headache relief with an early onset of action ( eg , @ % AVP-@ vs @ % placebo device at @ hour , P < @ ) .", "sentence_id": 3}
+{"abstract_id": "25355310", "label": "methods", "text": "In this double-blind , placebo-controlled , parallel-group study in adults with a history of migraine with or without aura , participants were randomized via computer-generated lists to AVP-@ or placebo device to treat a single migraine headache of moderate or severe intensity .", "sentence_id": 4}
+{"abstract_id": "25355310", "label": "methods", "text": "The primary endpoint was headache relief ( defined as reduction of headache pain intensity from severe or moderate migraine headache to mild or none ) at @ hours post-dose .", "sentence_id": 5}
+{"abstract_id": "25355310", "label": "results", "text": "Two hundred and thirty patients ( @ AVP-@ and @ placebo device ) were randomized , of whom @ ( @ and @ , respectively ) experienced a qualifying migraine headache ( their next migraine headache that reached moderate or severe intensity ) .", "sentence_id": 6}
+{"abstract_id": "25355310", "label": "results", "text": "A significantly greater proportion of AVP-@ patients reported headache relief at @ hours post-dose compared with those using the placebo device ( @ % vs @ % , P = @ , odds ratio @ , @ % confidence interval -LSB- @ , @ -RSB- ) .", "sentence_id": 7}
+{"abstract_id": "25355310", "label": "results", "text": "Between-group differences in headache relief were evident as early as @ minutes , reached statistical significance at @ minutes post-dose ( @ % vs @ % , P = @ ) , and were sustained at @ hours ( @ % vs @ % , P = @ ) and @ hours ( @ % vs @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25355310", "label": "results", "text": "Thirty-four percent of patients treated with AVP-@ were pain-free at @ hours compared with @ % using the placebo device ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25355310", "label": "results", "text": "More AVP-@ patients reported meaningful pain relief ( patient interpretation ) of migraine within @ hours of treatment vs placebo device ( @ % vs @ % , P < @ ) , and fewer required rescue medication ( @ % vs @ % , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25355310", "label": "results", "text": "Total migraine freedom ( patients with no headache , nausea , phonophobia , photophobia , or vomiting ) reached significance following treatment with AVP-@ at @ hour ( @ % vs @ % ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25355310", "label": "results", "text": "There were no serious adverse events ( AEs ) , and no systemic AEs occurred in more than one patient .", "sentence_id": 12}
+{"abstract_id": "25355310", "label": "results", "text": "Chest pain or pressure was not reported , and only one patient taking AVP-@ reported mild paresthesia .", "sentence_id": 13}
+{"abstract_id": "25355310", "label": "results", "text": "No other triptan sensations were reported .", "sentence_id": 14}
+{"abstract_id": "25355310", "label": "conclusions", "text": "Targeted delivery of a low-dose of sumatriptan powder via a novel , closed-palate , Breath Powered , intranasal device ( AVP-@ ) provided fast relief of moderate or severe migraine headache in adults that reached statistical significance over placebo by @ minutes .", "sentence_id": 15}
+{"abstract_id": "25355310", "label": "conclusions", "text": "The treatment was well tolerated with a low incidence of systemic AEs .", "sentence_id": 16}
+{"abstract_id": "25150159", "label": "objective", "text": "To characterize the pharmacokinetics ( PK ) and pharmacodynamics ( PD ) of a new insulin glargine comprising @ units mL ( -@ ) ( Gla-@ ) , compared with insulin glargine @ units mL ( -@ ) ( Gla-@ ) at steady state in people with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25150159", "label": "methods", "text": "A randomized , double-blind , crossover study ( N = @ ) was conducted , applying the euglycemic clamp technique over a period of @ h.", "sentence_id": 1}
+{"abstract_id": "25150159", "label": "methods", "text": "In this multiple-dose to steady-state study , participants received once-daily subcutaneous administrations of either @ ( cohort @ ) or @ units kg ( -@ ) ( cohort @ ) Gla-@ for @ days in one treatment period and @ units kg ( -@ ) Gla-@ for @ days in the other .", "sentence_id": 2}
+{"abstract_id": "25150159", "label": "methods", "text": "Here we focus on the results of a direct comparison between @ units kg ( -@ ) of each treatment .", "sentence_id": 3}
+{"abstract_id": "25150159", "label": "methods", "text": "PK and PD assessments performed on the last treatment day included serum insulin measurements using a radioimmunoassay and the automated euglycemic glucose clamp technique over @ h.", "sentence_id": 4}
+{"abstract_id": "25150159", "label": "results", "text": "At steady state , insulin concentration ( INS ) and glucose infusion rate ( GIR ) profiles of Gla-@ were more constant and more evenly distributed over @ h compared with those of Gla-@ and lasted longer , as supported by the later time ( @ h ) to @ % of the area under the serum INS and GIR time curves from time zero to @ h post dosing .", "sentence_id": 5}
+{"abstract_id": "25150159", "label": "results", "text": "Tight blood glucose control ( @ mg dL ( -@ ) ) was maintained for approximately @ h longer ( median of @ h ) with Gla-@ compared with Gla-@ .", "sentence_id": 6}
+{"abstract_id": "25150159", "label": "conclusions", "text": "Gla-@ provides more even steady-state PK and PD profiles and a longer duration of action than Gla-@ , extending blood glucose control well beyond @ h.", "sentence_id": 7}
+{"abstract_id": "26241253", "label": "objective", "text": "To evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device ( IUD ) placement .", "sentence_id": 0}
+{"abstract_id": "26241253", "label": "methods", "text": "We conducted a randomized , double-blind , placebo-controlled trial between July @ and March @ .", "sentence_id": 1}
+{"abstract_id": "26241253", "label": "methods", "text": "Patients received @ mg ketorolac or placebo saline intramuscular injection @ minutes before IUD placement .", "sentence_id": 2}
+{"abstract_id": "26241253", "label": "methods", "text": "The primary outcome was pain with IUD placement on a @-cm visual analog scale .", "sentence_id": 3}
+{"abstract_id": "26241253", "label": "methods", "text": "Sample size was calculated to provide @ % power to show a @-cm difference ( = @ ) in the primary outcome .", "sentence_id": 4}
+{"abstract_id": "26241253", "label": "methods", "text": "Secondary outcomes included pain with study drug injection , speculum insertion , tenaculum placement , uterine sounding , and at @ and @ minutes after IUD placement .", "sentence_id": 5}
+{"abstract_id": "26241253", "label": "results", "text": "A total of @ women participated in the study , @ in the ketorolac arm and @ in the placebo arm .", "sentence_id": 6}
+{"abstract_id": "26241253", "label": "results", "text": "There were no differences in baseline demographics including age , body mass index , and race .", "sentence_id": 7}
+{"abstract_id": "26241253", "label": "results", "text": "There were no differences in median pain scores for IUD placement in the placebo compared with ketorolac groups ( @ compared with @ cm , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26241253", "label": "results", "text": "There was a decrease in median pain scores at @ minutes ( @ compared with @ cm , P. @ ) and @ minutes ( @ compared with @ cm , P. @ ) after IUD placement but no difference for all other time points .", "sentence_id": 9}
+{"abstract_id": "26241253", "label": "results", "text": "Nulliparous participants ( n = @ , eight per arm ) had a decrease in pain scores with IUD placement ( @ compared with @ cm , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26241253", "label": "results", "text": "In this study , @ % of participants in the placebo group and @ % in the ketorolac group reported injection pain was as painful as IUD placement .", "sentence_id": 11}
+{"abstract_id": "26241253", "label": "conclusions", "text": "Ketorolac does not reduce pain with IUD placement but does reduce pain at @ and @ minutes after placement .", "sentence_id": 12}
+{"abstract_id": "25381300", "label": "objective", "text": "To study activin signaling and its blockade in sporadic inclusion body myositis ( sIBM ) through translational studies and a randomized controlled trial .", "sentence_id": 0}
+{"abstract_id": "25381300", "label": "methods", "text": "We measured transforming growth factor signaling by SMAD@/@ phosphorylation in muscle biopsies of @ patients with neuromuscular disease ( @ with sIBM ) .", "sentence_id": 1}
+{"abstract_id": "25381300", "label": "methods", "text": "We tested inhibition of activin receptors IIA and IIB ( ActRII ) in @ patients with sIBM using one dose of bimagrumab ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25381300", "label": "methods", "text": "The primary outcome was the change in right thigh muscle volume by MRI at @ weeks .", "sentence_id": 3}
+{"abstract_id": "25381300", "label": "methods", "text": "Lean body mass , strength , and function were secondary outcomes .", "sentence_id": 4}
+{"abstract_id": "25381300", "label": "methods", "text": "Twelve of the patients ( @ bimagrumab , @ placebo ) participated in a subsequent @-week observation phase .", "sentence_id": 5}
+{"abstract_id": "25381300", "label": "results", "text": "Muscle SMAD@/@ phosphorylation was higher in sIBM than in other muscle diseases studied ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25381300", "label": "results", "text": "Eight weeks after dosing , the bimagrumab-treated patients increased thigh muscle volume ( right leg +@ % compared with placebo , p = @ ; left leg +@ % , p = @ ) and lean body mass ( +@ % compared with placebo , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25381300", "label": "results", "text": "Subsequently , bimagrumab-treated patients had improved @-minute walking distance , which peaked at @ weeks ( +@ % , p = @ ) compared with placebo .", "sentence_id": 8}
+{"abstract_id": "25381300", "label": "results", "text": "There were no serious adverse events ; the main adverse events with bimagrumab were mild acne and transient involuntary muscle contractions .", "sentence_id": 9}
+{"abstract_id": "25381300", "label": "conclusions", "text": "Transforming growth factor superfamily signaling , at least through ActRII , is implicated in the pathophysiology of sIBM .", "sentence_id": 10}
+{"abstract_id": "25381300", "label": "conclusions", "text": "Inhibition of ActRII increased muscle mass and function in this pilot trial , offering a potential novel treatment of sIBM .", "sentence_id": 11}
+{"abstract_id": "25381300", "label": "methods", "text": "This study provides Class I evidence that for patients with inclusion body myositis , bimagrumab increases thigh muscle volume at @ weeks .", "sentence_id": 12}
+{"abstract_id": "24559178", "label": "background", "text": "Although dental care settings provide an exceptional opportunity to reach smokers and provide brief cessation advice and treatment to reduce oral and other tobacco-related health conditions , dental care providers demonstrate limited adherence to evidence-based guidelines for treatment of tobacco use and dependence .", "sentence_id": 0}
+{"abstract_id": "24559178", "label": "methods", "text": "Guided by a multi-level , conceptual framework that emphasizes changes in provider beliefs and organizational characteristics as drivers of improvement in tobacco treatment delivery , the current protocol will use a cluster , randomized design and multiple data sources ( patient exit interviews , provider surveys , site observations , chart audits , and semi-structured provider interviews ) to study the process of implementing clinical practice guidelines for treating tobacco dependence in @ public dental care clinics in New York City .", "sentence_id": 1}
+{"abstract_id": "24559178", "label": "methods", "text": "The specific aims of this comparative-effectiveness research trial are to : compare the effectiveness of three promising strategies for implementation of tobacco use treatment guidelines-staff training and current best practices ( CBP ) , CBP + provider performance feedback ( PF ) , and CBP+PF + provider reimbursement for delivery of tobacco cessation treatment ( pay-for-performance , or P@P ) ; examine potential theory-driven mechanisms hypothesized to explain the comparative effectiveness of three strategies for implementation ; and identify baseline organizational factors that influence the implementation of evidence-based tobacco use treatment practices in dental clinics .", "sentence_id": 2}
+{"abstract_id": "24559178", "label": "methods", "text": "The primary outcome is change in providers ' tobacco treatment practices and the secondary outcomes are cost per quit , use of tobacco cessation treatments , quit attempts , and smoking abstinence .", "sentence_id": 3}
+{"abstract_id": "24559178", "label": "conclusions", "text": "We hypothesize that the value of these promising implementation strategies is additive and that incorporating all three strategies ( CBP , PF , and P@P ) will be superior to CBP alone and CBP+PF in improving delivery of cessation assistance to smokers .", "sentence_id": 4}
+{"abstract_id": "24559178", "label": "conclusions", "text": "The findings will improve knowledge pertinent to the implementation , dissemination , and sustained utilization of evidence-based tobacco use treatment in dental practices .", "sentence_id": 5}
+{"abstract_id": "24875964", "label": "methods", "text": "Multicenter , randomized , controlled trial on preoperative pain neuroscience education ( NE ) for lumbar radiculopathy .", "sentence_id": 0}
+{"abstract_id": "24875964", "label": "objective", "text": "To determine if the addition of NE to usual preoperative education would result in superior outcomes with regard to pain , function , surgical experience , and health care utilization postsurgery .", "sentence_id": 1}
+{"abstract_id": "24875964", "label": "background", "text": "One in @ patients after lumbar surgery ( LS ) for radiculopathy experience persistent pain and disability , which is nonresponsive to perioperative treatments .", "sentence_id": 2}
+{"abstract_id": "24875964", "label": "background", "text": "NE focusing on the neurophysiology of pain has been shown to decrease pain and disability in populations with chronic low back pain .", "sentence_id": 3}
+{"abstract_id": "24875964", "label": "methods", "text": "Eligible patients scheduled for LS for radiculopathy were randomized to receive either preoperative usual care ( UC ) or a combination of UC plus @ session of NE delivered by a physical therapist ( verbal one-on-one format ) and a NE booklet .", "sentence_id": 4}
+{"abstract_id": "24875964", "label": "methods", "text": "Sixty-seven patients completed the following outcomes prior to LS ( baseline ) , and @ , @ , @ , and @ months after LS : low back pain ( numeric rating scale ) , leg pain ( numeric rating scale ) , function ( Oswestry Disability Index ) , various beliefs and experiences related to LS ( @-item survey with Likert scale responses ) , and postoperative utilization of health care ( utilization of health care questionnaire ) .", "sentence_id": 5}
+{"abstract_id": "24875964", "label": "results", "text": "At @-year follow-up , there were no statistical differences between the experimental and control groups with regard to primary outcome measure of low back pain ( P = @ ) , leg pain ( P = @ ) , and function ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24875964", "label": "results", "text": "In a majority of the categories regarding surgical experience , the NE group scored significantly better : better prepared for LS ( P = @ ) ; preoperative session preparing them for LS ( P < @ ) and LS meeting their expectations ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24875964", "label": "results", "text": "Health care utilization post-LS also favored the NE group ( P = @ ) resulting in @ % less health care expenditure compared with the control group in the @-year follow-up period .", "sentence_id": 8}
+{"abstract_id": "24875964", "label": "conclusions", "text": "NE resulted in significant behavior change .", "sentence_id": 9}
+{"abstract_id": "24875964", "label": "conclusions", "text": "Despite a similar pain and functional trajectory during the @-year trial , patients with LS who received NE viewed their surgical experience more favorably and used less health care facility in the form of medical tests and treatments .", "sentence_id": 10}
+{"abstract_id": "25005057", "label": "objective", "text": "To compare extra-abdominal repair of the uterine incision at cesarean delivery with in situ repair .", "sentence_id": 0}
+{"abstract_id": "25005057", "label": "methods", "text": "The present study was a double-blind randomized controlled trial conducted at a university hospital in Egypt during @-@ , and included women with an indication for cesarean delivery .", "sentence_id": 1}
+{"abstract_id": "25005057", "label": "methods", "text": "Extra-abdominal repair was used in group @ ( n = @ ) and in situ repair in group @ ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25005057", "label": "methods", "text": "The primary outcome measure was the surgery duration .", "sentence_id": 3}
+{"abstract_id": "25005057", "label": "results", "text": "Surgery duration was significantly longer in group @ than group @ ( @ minutes vs @ minutes ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25005057", "label": "results", "text": "More patients in group @ than in group @ had postoperative moderate-to-severe pain ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; P = @ ) and needed additional postoperative analgesia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25005057", "label": "results", "text": "Moreover , mean time to bowel movement was longer in group @ than in group @ ( @ hours vs @ hours ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25005057", "label": "conclusions", "text": "In situ uterine closure is more advantageous than extra-abdominal repair in terms of surgery duration , postoperative pain and need for additional analgesia , and return of bowel movement .", "sentence_id": 7}
+{"abstract_id": "25005057", "label": "conclusions", "text": "ClinicalTrials.gov : NCT@ .", "sentence_id": 8}
+{"abstract_id": "24685085", "label": "objective", "text": "The aim of this study was to compare the efficacy of low molecular weight heparin ( LMWH ) combined with graduated compression stockings ( GCS ) with GCS alone as prophylactic measures for venous thromboembolism ( VTE ) in post-operative patients with gynecologic cancer .", "sentence_id": 0}
+{"abstract_id": "24685085", "label": "methods", "text": "Patients diagnosed with gynecologic cancer undergoing primary major surgery between @ and @ in our institute were randomized to receive LMWH+GCS or GCS as VTE prophylaxis post-operatively .", "sentence_id": 1}
+{"abstract_id": "24685085", "label": "results", "text": "Altogether @ patients were enrolled .", "sentence_id": 2}
+{"abstract_id": "24685085", "label": "results", "text": "The incidence of VTE in patients treated with LMWH + GCS was significantly lower than that in patients using GCS alone ( @ % Vs. @ % , P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24685085", "label": "results", "text": "There were no severe bleeding complications in the patients with prophylactic use of LMWH and the occurrence rate of wound dehiscence was comparable between the two groups ( P > @ ) .", "sentence_id": 4}
+{"abstract_id": "24685085", "label": "results", "text": "Multivariable logistic regression analysis revealed that age over @ years ( P = @ ) , duration of operation over @ hours ( P = @ ) and without prophylactic use of LMWH ( P = @ ) were independent risk factors for VTE .", "sentence_id": 5}
+{"abstract_id": "24685085", "label": "conclusions", "text": "Dual prophylaxis with LMWH and GCS should be recommended for gynecologic cancer patients undergoing major surgery for its better efficacy than GCS .", "sentence_id": 6}
+{"abstract_id": "24685085", "label": "conclusions", "text": "Prophylactic use of LMWH is safe and convenient .", "sentence_id": 7}
+{"abstract_id": "24685085", "label": "conclusions", "text": "Patients with older age and prolonged operation time are at highest risk of developing VTE post-operatively .", "sentence_id": 8}
+{"abstract_id": "24598599", "label": "objective", "text": "Until recently , very few intervention studies have investigated the effects of whole-grain cereals on postprandial glucose , insulin and lipid metabolism , and the existing studies have provided mixed results .", "sentence_id": 0}
+{"abstract_id": "24598599", "label": "objective", "text": "The objective of this study was to evaluate the effects of a @-week intervention with either a whole-grain-based or a refined cereal-based diet on postprandial glucose , insulin and lipid metabolism in individuals with metabolic syndrome .", "sentence_id": 1}
+{"abstract_id": "24598599", "label": "results", "text": "Sixty-one men and women age range @-@ years , with the metabolic syndrome were recruited to participate in this study using a parallel group design .", "sentence_id": 2}
+{"abstract_id": "24598599", "label": "results", "text": "After a @-week run-in period , participants were randomly assigned to a @-week diet based on whole-grain products ( whole-grain group ) or refined cereal products ( control group ) .", "sentence_id": 3}
+{"abstract_id": "24598599", "label": "results", "text": "Blood samples were taken at the beginning and end of the intervention , both fasting and @ h after a lunch , to measure biochemical parameters .", "sentence_id": 4}
+{"abstract_id": "24598599", "label": "results", "text": "Generalized linear model ( GLM ) was used for between-group comparisons .", "sentence_id": 5}
+{"abstract_id": "24598599", "label": "results", "text": "Overall , @ participants in the control group and @ in the whole-grain group completed the dietary intervention .", "sentence_id": 6}
+{"abstract_id": "24598599", "label": "results", "text": "Drop-outs ( five in the control and two in the whole-grain group ) did not affect randomization .", "sentence_id": 7}
+{"abstract_id": "24598599", "label": "results", "text": "After @ weeks , postprandial insulin and triglyceride responses ( evaluated as average change @ and @ h after the meal , respectively ) decreased by @ % and @ % , respectively , in the whole-grain group compared to the run-in period .", "sentence_id": 8}
+{"abstract_id": "24598599", "label": "results", "text": "Postprandial insulin and triglyceride responses were significantly lower at the end of the intervention in the whole-grain group compared to the control group ( p = @ and p = @ ; respectively ) whereas there was no change in postprandial response of glucose and other parameters evaluated .", "sentence_id": 9}
+{"abstract_id": "24598599", "label": "conclusions", "text": "A twelve week whole-grain cereal-based diet , compared to refined cereals , reduced postprandial insulin and triglycerides responses .", "sentence_id": 10}
+{"abstract_id": "24598599", "label": "conclusions", "text": "This finding may have implications for type @ diabetes risk and cardiovascular disease .", "sentence_id": 11}
+{"abstract_id": "25875256", "label": "background", "text": "Oral ulcers , the hallmark of Behet 's syndrome , can be resistant to conventional treatment ; therefore , alternative agents are needed .", "sentence_id": 0}
+{"abstract_id": "25875256", "label": "background", "text": "Apremilast is an oral phosphodiesterase-@ inhibitor that modulates several inflammatory pathways .", "sentence_id": 1}
+{"abstract_id": "25875256", "label": "methods", "text": "We conducted a phase @ , multicenter , placebo-controlled study in which @ patients with Behet 's syndrome who had two or more oral ulcers were randomly assigned to receive @ mg of apremilast twice daily or placebo for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25875256", "label": "methods", "text": "This regimen was followed by a @-week extension phase in which the placebo group was switched to apremilast and a @-day post-treatment observational follow-up phase .", "sentence_id": 3}
+{"abstract_id": "25875256", "label": "methods", "text": "The patients and clinicians were unaware of the study assignments throughout the trial .", "sentence_id": 4}
+{"abstract_id": "25875256", "label": "methods", "text": "The primary end point was the number of oral ulcers at week @ .", "sentence_id": 5}
+{"abstract_id": "25875256", "label": "methods", "text": "Secondary outcomes included pain from these ulcers ( measured on a @-mm visual-analogue scale , with higher scores indicating worse pain ) , the number of genital ulcers , overall disease activity , and quality of life .", "sentence_id": 6}
+{"abstract_id": "25875256", "label": "results", "text": "The mean ( SD ) number of oral ulcers per patient at week @ was significantly lower in the apremilast group than in the placebo group ( @ vs. @ ) ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25875256", "label": "results", "text": "The mean decline in pain from oral ulcers from baseline to week @ was greater with apremilast than with placebo ( -@ mm vs. -@ mm ) ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25875256", "label": "results", "text": "Nausea , vomiting , and diarrhea were more common in the apremilast group ( with @ , @ , and @ incidents , respectively , among @ patients ) than in the placebo group ( with @ , @ , and @ incidents , respectively , among @ patients ) , findings that were similar to those in previous studies of apremilast .", "sentence_id": 9}
+{"abstract_id": "25875256", "label": "results", "text": "There were two serious adverse events in patients receiving apremilast .", "sentence_id": 10}
+{"abstract_id": "25875256", "label": "conclusions", "text": "Apremilast was effective in treating oral ulcers , which are the cardinal manifestation of Behet 's syndrome .", "sentence_id": 11}
+{"abstract_id": "25875256", "label": "conclusions", "text": "This preliminary study was neither large enough nor long enough to assess long-term efficacy , the effect on other manifestations of Behet 's syndrome , or the risk of uncommon serious adverse events .", "sentence_id": 12}
+{"abstract_id": "25875256", "label": "conclusions", "text": "( Funded by Celgene ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 13}
+{"abstract_id": "25116277", "label": "objective", "text": "Leg compression is considered basic treatment for superficial vein thrombosis ( SVT ) , although scientific proof for its efficacy is lacking .", "sentence_id": 0}
+{"abstract_id": "25116277", "label": "objective", "text": "The aim of the study was to evaluate the therapeutic effect of compression stockings on isolated SVT of the legs .", "sentence_id": 1}
+{"abstract_id": "25116277", "label": "methods", "text": "This was a single-center randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "25116277", "label": "methods", "text": "Eighty patients with isolated SVT of the legs were instructed to wear compression stockings ( @-@mmHg ) ( CG ) or no compression ( NCG ) for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25116277", "label": "methods", "text": "All patients received low molecular weight heparin ( LMWH ) at prophylactic dosage .", "sentence_id": 4}
+{"abstract_id": "25116277", "label": "methods", "text": "Non-steroidal anti-inflammatory drugs ( NSAIDs ) were allowed .", "sentence_id": 5}
+{"abstract_id": "25116277", "label": "methods", "text": "The primary outcome variable was the reduction of pain as assessed by a visual analog scale ( VAS ) and the Lowenberg test .", "sentence_id": 6}
+{"abstract_id": "25116277", "label": "methods", "text": "Secondary outcomes were the consumption of analgesics , thrombus length , skin erythema , D-dimer , and quality of life ( QoL ) .", "sentence_id": 7}
+{"abstract_id": "25116277", "label": "results", "text": "Seventy-three patients completed the study .", "sentence_id": 8}
+{"abstract_id": "25116277", "label": "results", "text": "Clinical symptoms and QoL significantly improved from baseline to day @ in both groups ( p < @ for VAS , Lowenberg test , thrombus length , and erythema ; p < @ for QoL ) , and consumption of analgesics and D-dimer significantly decreased ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25116277", "label": "results", "text": "There was no significant difference between the groups for all tested variables .", "sentence_id": 10}
+{"abstract_id": "25116277", "label": "results", "text": "At day @ , patients in the CG revealed a significantly faster thrombus regression ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25116277", "label": "conclusions", "text": "Adding compression stockings for @ weeks to LMWH and NSAIDs does not bring significant additional benefit in the treatment of isolated SVT .", "sentence_id": 12}
+{"abstract_id": "25116277", "label": "conclusions", "text": "When worn for @ week , compression stockings stimulate significantly faster thrombus regression .", "sentence_id": 13}
+{"abstract_id": "24766353", "label": "objective", "text": "Two reports of infants found dead after sleeping in baby hammocks have raised international concern about the safety of infant hammocks .", "sentence_id": 0}
+{"abstract_id": "24766353", "label": "objective", "text": "We therefore tested whether hammock sleep affected oxygenation in infants , when they were at an age of high risk of sudden , unexpected infant death .", "sentence_id": 1}
+{"abstract_id": "24766353", "label": "methods", "text": "Healthy , full-term @ - to @-week-old infants were randomised to sleep either in a commercially available hammock ( n = @ ) or a standard bassinet ( n = @ ) , and sleep state , oxygen desaturation ( a fall in peripheral haemoglobin oxygen saturation ( SpO@ ) @ % , for @ sec from baseline to nadir ) , apnoea and hypopnoea , and mean SpO@ were analysed .", "sentence_id": 2}
+{"abstract_id": "24766353", "label": "results", "text": "There was no significant difference in mean SpO@ ( both @ % ) or rate of oxygen desaturation events between the hammock and the bassinet cot ( mean SD , @ @ vs. @ @ events per hour ) , but infants slept less in the hammock ( @ @ vs. @ @ min , p < @ ) .", "sentence_id": 3}
+{"abstract_id": "24766353", "label": "conclusions", "text": "When correctly used , the hammock sleep position did not compromise the upper airway of sleeping infants .", "sentence_id": 4}
+{"abstract_id": "24766353", "label": "conclusions", "text": "The significance of shorter duration of sleep in the hammocks is unclear .", "sentence_id": 5}
+{"abstract_id": "24766353", "label": "conclusions", "text": "These findings should not be applied to all baby hammocks , nor to older babies , particularly once the infant can roll .", "sentence_id": 6}
+{"abstract_id": "24766353", "label": "conclusions", "text": "Given that it is not possible to predict when an infant will be able to roll , we strongly recommend that hammocks should not be used for unsupervised sleep .", "sentence_id": 7}
+{"abstract_id": "24360173", "label": "objective", "text": "To explore the effects of reconstructing method ( narrow gastric tube ( NGT ) versus whole stomach ( WS ) ) on health-related quality of life ( HRQL ) in patients during a @-year follow-up .", "sentence_id": 0}
+{"abstract_id": "24360173", "label": "methods", "text": "In a prospective randomized single-center study from @ to @ , @ patients underwent esophagectomy for cancer .", "sentence_id": 1}
+{"abstract_id": "24360173", "label": "methods", "text": "They were divided into NGT ( n = @ ) and WS ( n = @ ) groups .", "sentence_id": 2}
+{"abstract_id": "24360173", "label": "methods", "text": "To assess HRQL , a questionnaire in references to EORTC-QLQ-C@ and QLQ-OES@ was administered at @ weeks , @ months , @ year , @ year and @ years post-operation .", "sentence_id": 3}
+{"abstract_id": "24360173", "label": "methods", "text": "Their clinical data were collected prospectively and follow-up was performed regularly .", "sentence_id": 4}
+{"abstract_id": "24360173", "label": "results", "text": "The patients in the NGT group reported significantly ( P < @ ) better average scores of HRQL at both @ months and @ year.However , no significant difference in average scores of HRQL was found at @ years .", "sentence_id": 5}
+{"abstract_id": "24360173", "label": "results", "text": "Patients in the NGT group reported significantly ( P < @ ) better scores of reflux at @ weeks , @ months and @ year.Nausea was the only item with significant difference on HRQL at @ years and @ years.No significant difference existed between two groups with regards to cumulative survival rate at @ years .", "sentence_id": 6}
+{"abstract_id": "24360173", "label": "conclusions", "text": "No significant difference existed between two groups with regards to cumulative survival rate at @ years .", "sentence_id": 7}
+{"abstract_id": "24360173", "label": "conclusions", "text": "The patients with gastric tube reconstruction after oncologic esophagectomy present better HRQL.Further studies are warranted to perform survival analysis beyond @ year post-operation .", "sentence_id": 8}
+{"abstract_id": "24337060", "label": "objective", "text": "It was to test the validity and reliability of an online version of the Female Sexual Function Index ( FSFI ) .", "sentence_id": 0}
+{"abstract_id": "24337060", "label": "methods", "text": "An online version of the FSFI was compared to the pen and paper traditional version .", "sentence_id": 1}
+{"abstract_id": "24337060", "label": "methods", "text": "Physiotherapy students in three cities were randomly allocated to two groups - G-pp/ol ( n = @ ) and G-ol/pp ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24337060", "label": "methods", "text": "G-pp/ol women replied to th FSFI using the traditional pen and paper method , while G-ol/pp women answered an online version of the same questionnaire .", "sentence_id": 3}
+{"abstract_id": "24337060", "label": "methods", "text": "Data were collected ageing after @ days , when G-pp/ol women answered the online version while G-ol/pp women answered on paper .", "sentence_id": 4}
+{"abstract_id": "24337060", "label": "methods", "text": "All data were transferred to SPSS software .", "sentence_id": 5}
+{"abstract_id": "24337060", "label": "methods", "text": "Demographic differences between the test two groups were determined by Student 's t-test or Fisher exact ( @ % CI ; p > @ ) .", "sentence_id": 6}
+{"abstract_id": "24337060", "label": "methods", "text": "Association and correlation between the responses of G-pp/ol and G-ol/pp were assessed for each sample by the t-test and Pearson 's coefficient .", "sentence_id": 7}
+{"abstract_id": "24337060", "label": "methods", "text": "An identical strategy was used for intragroup comparisons .", "sentence_id": 8}
+{"abstract_id": "24337060", "label": "results", "text": "A total of @ women participated in the study and @ ( @ % ) giving up the second collection .", "sentence_id": 9}
+{"abstract_id": "24337060", "label": "results", "text": "There were no demographic differences between groups .", "sentence_id": 10}
+{"abstract_id": "24337060", "label": "results", "text": "Fifteen of the @ FSFI questions were associated and correlated between the two groups in both test and the retest .", "sentence_id": 11}
+{"abstract_id": "24337060", "label": "results", "text": "The intragroup analysis revealed that all FSFI questions and scores were associated and weakly correlated for the same group during both test and retest .", "sentence_id": 12}
+{"abstract_id": "24337060", "label": "conclusions", "text": "The online version of the FSFI showed acceptable validity and reliability when compared to the paper version , and can justify the choice of this modality , especially in studies involving private questions .", "sentence_id": 13}
+{"abstract_id": "24607889", "label": "objective", "text": "We aimed to compare the clinical outcomes of intra-articular calcaneus fractures treated with open reduction and internal fixation with conventional plate via L-shaped lateral approach ( routine treatment ) versus those with percutaneous plate via a sinus tarsi approach ( minimally invasive treatment ) .", "sentence_id": 0}
+{"abstract_id": "24607889", "label": "methods", "text": "One hundred and seventeen displaced intra-articular calcaneal fractures in @ patients from January @ and September @ were randomly allocated to receive routine treatment ( @ patients ) or minimally invasive treatment ( @ patients ) .", "sentence_id": 1}
+{"abstract_id": "24607889", "label": "methods", "text": "Operative time , preoperative and postoperative calcaneal height , width , length , Bhlers angle , Gissanes angle , and incision healing were recorded .", "sentence_id": 2}
+{"abstract_id": "24607889", "label": "methods", "text": "Maryland foot score system was used to evaluate clinical functional outcomes .", "sentence_id": 3}
+{"abstract_id": "24607889", "label": "results", "text": "The operative time of minimally invasive group was significantly shorter than that of the routine group -LSB- @-@ min ( mean , @ min ) vs @-@ min ( mean , @ min ) , p < @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "24607889", "label": "results", "text": "Postoperative X-ray showed the calcaneal height , width , length , Bhlers angle and Gissanes angle were significantly improved in both two groups , and no significant difference was observed between two groups postoperatively .", "sentence_id": 5}
+{"abstract_id": "24607889", "label": "results", "text": "No feet developed wound complications in minimally invasive group , but incision complications occurred in @ feet in routine group .", "sentence_id": 6}
+{"abstract_id": "24607889", "label": "results", "text": "The excellent and good rate according to the Maryland foot score was significantly higher in minimally invasive group than that in the routine group ( @ % vs @ % ) .", "sentence_id": 7}
+{"abstract_id": "24607889", "label": "conclusions", "text": "Compared with L-shaped lateral approach treatment of displaced intra-articular calcaneal fractures , sinus tarsi approach for the reduction and internal fixation with percutaneous plate seems to be more safe and effective , with satisfactory clinical therapeutic effects and without postoperative complications .", "sentence_id": 8}
+{"abstract_id": "25409678", "label": "background", "text": "The incidence of acute kidney injury ( AKI ) is estimated at @ to @ % in patients admitted to intensive care units ( ICU ) and often requires renal replacement therapy ( RRT ) .", "sentence_id": 0}
+{"abstract_id": "25409678", "label": "background", "text": "ICU mortality in AKI patients can exceed @ % .", "sentence_id": 1}
+{"abstract_id": "25409678", "label": "background", "text": "Venous catheters are the preferred vascular access method for AKI patients requiring RRT , but carry a risk of catheter thrombosis or infection .", "sentence_id": 2}
+{"abstract_id": "25409678", "label": "background", "text": "Catheter lock solutions are commonly used to prevent such complications .", "sentence_id": 3}
+{"abstract_id": "25409678", "label": "background", "text": "Heparin and citrate locks are both widely used for tunneled , long-term catheters , but few studies have compared citrate versus heparin for patients with short-term , non-tunneled catheters .", "sentence_id": 4}
+{"abstract_id": "25409678", "label": "background", "text": "We aim to compare citrate @ % catheter lock solution versus heparin in terms of event-free survival of the first non-tunneled hemodialysis catheter inserted in ICU patients with AKI requiring RRT .", "sentence_id": 5}
+{"abstract_id": "25409678", "label": "background", "text": "Secondary objectives are the rate of fibrinolysis , incidence of catheter thrombosis and catheter-related infection per @,@ catheter days , length of stay in ICU and in-hospital and @-day mortality .", "sentence_id": 6}
+{"abstract_id": "25409678", "label": "methods", "text": "The VERROU-REA study is a randomized , prospective , multicenter , double-blind , parallel-group , controlled superiority study carried out in the medical , surgical and nephrological ICUs of two large university hospitals in eastern France .", "sentence_id": 7}
+{"abstract_id": "25409678", "label": "methods", "text": "A catheter lock solution composed of trisodium citrate at @ % will be compared to unfractionated heparin at a concentration of @,@ IU/mL .", "sentence_id": 8}
+{"abstract_id": "25409678", "label": "methods", "text": "All consecutive adult patients with AKI requiring extracorporeal RRT , and in whom a first non-tunneled catheter is to be inserted by the jugular or femoral approach , will be eligible .", "sentence_id": 9}
+{"abstract_id": "25409678", "label": "methods", "text": "Catheters inserted by the subclavian approach , patients with acute liver failure , thrombopenia or contraindication to systemic anticoagulation will be excluded .", "sentence_id": 10}
+{"abstract_id": "25409678", "label": "methods", "text": "Patients will be followed up daily in accordance with standard practices for RRT until death or discharge .", "sentence_id": 11}
+{"abstract_id": "25409678", "label": "conclusions", "text": "Data is scarce regarding the use of non-tunneled catheters in the ICU setting in patients with AKI .", "sentence_id": 12}
+{"abstract_id": "25409678", "label": "conclusions", "text": "This study will provide an evidence base for recommendations regarding the use of anticoagulant catheter locks for the prevention of dysfunction in non-tunneled hemodialysis catheters in patients with AKI in critical or intensive care .", "sentence_id": 13}
+{"abstract_id": "24656704", "label": "objective", "text": "This is a controlled , prospective study which compares the effects of a low-dose heat patch for self-medication on the reduction of pain symptoms in dysmenorrhea .", "sentence_id": 0}
+{"abstract_id": "24656704", "label": "methods", "text": "The sample group included female sophomore students studying at a university in Istanbul , Turkey , between @ and @ .", "sentence_id": 1}
+{"abstract_id": "24656704", "label": "methods", "text": "These female participants completed the Dysmenorrhea Identification Form to determine the sample group , and a total of @ female students possessed the eligible criteria .", "sentence_id": 2}
+{"abstract_id": "24656704", "label": "methods", "text": "The research control group consisted of @ patients , the analgesia group consisted of @ , and the heat patch group consisted of @ .", "sentence_id": 3}
+{"abstract_id": "24656704", "label": "methods", "text": "The control group did not use any treatments , while the self-medication group used analgesic medication ( single dose ) , and the heat patch group applied a heat patch on the lower abdomen , against the skin , for an application period of @ menstrual cycles .", "sentence_id": 4}
+{"abstract_id": "24656704", "label": "methods", "text": "Using a visual analog scale ( VAS ) , the pain severity was recorded at the baseline , after @ hours of intervention , and after @ hours of intervention .", "sentence_id": 5}
+{"abstract_id": "24656704", "label": "methods", "text": "The data were examined using ANOVA .", "sentence_id": 6}
+{"abstract_id": "24656704", "label": "results", "text": "There were significant differences between the groups in terms of pain severity after @ hours of application ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24656704", "label": "results", "text": "All groups had similar pain levels at baseline and during the fourth and eighth hours , with no significant differences between the groups during the first and the second menstrual cycles ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24656704", "label": "conclusions", "text": "The authors conclude that the heat patch is an effective method for reducing dysmenorrhea .", "sentence_id": 9}
+{"abstract_id": "24670297", "label": "background", "text": "Paradoxically , a breast cancer risk reduction with conjugated equine estrogens ( CEE ) and a risk elevation with CEE plus medroxyprogesterone acetate ( CEE+MPA ) were observed in the Women 's Health Initiative ( WHI ) randomized controlled trials .", "sentence_id": 0}
+{"abstract_id": "24670297", "label": "background", "text": "The effects of hormone therapy on serum sex hormone levels , and on the association between baseline sex hormones and disease risk , may help explain these divergent breast cancer findings .", "sentence_id": 1}
+{"abstract_id": "24670297", "label": "methods", "text": "Serum sex hormone concentrations were measured for @ breast cancer cases in the CEE+MPA trial and for @ cases in the CEE trial along with corresponding pair-matched controls , nested within the WHI trials of healthy postmenopausal women .", "sentence_id": 2}
+{"abstract_id": "24670297", "label": "methods", "text": "Association and mediation analyses , to examine the extent to which sex hormone levels and changes can explain the breast cancer findings , were conducted using logistic regression .", "sentence_id": 3}
+{"abstract_id": "24670297", "label": "results", "text": "Following CEE treatment , breast cancer risk was associated with higher concentrations of baseline serum estrogens , and with lower concentrations of sex hormone binding globulin .", "sentence_id": 4}
+{"abstract_id": "24670297", "label": "results", "text": "However , following CEE+MPA , there was no association of breast cancer risk with baseline sex hormone levels .", "sentence_id": 5}
+{"abstract_id": "24670297", "label": "results", "text": "The sex hormone changes from baseline to year @ provided an explanation for much of the reduced breast cancer risk with CEE .", "sentence_id": 6}
+{"abstract_id": "24670297", "label": "results", "text": "Specifically , the treatment odds ratio ( @ % confidence interval ) increased from @ ( @ , @ ) to @ ( @ , @ ) when the year @ measures were included in the logistic regression analysis .", "sentence_id": 7}
+{"abstract_id": "24670297", "label": "results", "text": "In comparison , the CEE+MPA odds ratio was essentially unchanged when these year @ measures were included .", "sentence_id": 8}
+{"abstract_id": "24670297", "label": "conclusions", "text": "Breast cancer risk remains low following CEE use among women having favorable baseline sex hormone profiles , but CEE+MPA evidently produces a breast cancer risk for all women similar to that for women having an unfavorable baseline sex hormone profile .", "sentence_id": 9}
+{"abstract_id": "24670297", "label": "conclusions", "text": "These patterns could reflect breast ductal epithelial cell stimulation by CEE+MPA that is substantially avoided with CEE , in conjunction with relatively more favorable effects of either regimen following a sustained period of estrogen deprivation .", "sentence_id": 10}
+{"abstract_id": "24670297", "label": "conclusions", "text": "These findings may have implications for other hormone therapy formulations and routes of delivery .", "sentence_id": 11}
+{"abstract_id": "25184356", "label": "objective", "text": "Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL ) , a rare autosomal dominant disorder caused by NOTCH@ mutations , is characterized by vascular smooth muscle and endothelial cells abnormalities , altered vasoreactivity , and recurrent lacunar infarcts .", "sentence_id": 0}
+{"abstract_id": "25184356", "label": "objective", "text": "Vasomotor function may represent a key factor for disease progression .", "sentence_id": 1}
+{"abstract_id": "25184356", "label": "objective", "text": "Tetrahydrobiopterin , essential cofactor for nitric oxide synthesis in endothelial cells , ameliorates endothelial function .", "sentence_id": 2}
+{"abstract_id": "25184356", "label": "objective", "text": "We assessed whether supplementation with sapropterin , a synthetic tetrahydrobiopterin analog , improves endothelium-dependent vasodilation in CADASIL patients .", "sentence_id": 3}
+{"abstract_id": "25184356", "label": "methods", "text": "In a @-month , multicenter randomized , double-blind , placebo-controlled trial , CADASIL patients aged @ to @ years were randomly assigned to receive placebo or sapropterin @ to @ mg BID .", "sentence_id": 4}
+{"abstract_id": "25184356", "label": "methods", "text": "The primary end point was change in the reactive hyperemia index by peripheral arterial tonometry at @ months .", "sentence_id": 5}
+{"abstract_id": "25184356", "label": "methods", "text": "We also assessed the safety and tolerability of sapropterin .", "sentence_id": 6}
+{"abstract_id": "25184356", "label": "methods", "text": "Analysis was done by intention-to-treat .", "sentence_id": 7}
+{"abstract_id": "25184356", "label": "results", "text": "The intention-to-treat population included @ patients .", "sentence_id": 8}
+{"abstract_id": "25184356", "label": "results", "text": "We found no significant difference between sapropterin ( n = @ ) and placebo ( n = @ ) in the primary end point ( mean difference in reactive hyperemia index by peripheral arterial tonometry changes @ -LSB- @ % confidence interval , -@ , @ -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "25184356", "label": "results", "text": "Reactive hyperemia index by peripheral arterial tonometry increased after @ months in @ % of patients on sapropterin and in @ % on placebo ; however , after adjustment for age , sex , and clinical characteristics , improvement was not associated with treatment arm .", "sentence_id": 10}
+{"abstract_id": "25184356", "label": "results", "text": "The proportion of patients with adverse events was similar on sapropterin and on placebo ( @ % versus @ % ) ; serious adverse events occurred in @ % versus @ % , respectively .", "sentence_id": 11}
+{"abstract_id": "25184356", "label": "conclusions", "text": "Sapropterin was safe and well-tolerated at the average dose of @ mg/kg/day , but did not affect endothelium-dependent vasodilation in CADASIL patients .", "sentence_id": 12}
+{"abstract_id": "24322060", "label": "objective", "text": "Community-based efforts to prevent adolescent problem behaviors are essential to promote public health and achieve collective impact community wide .", "sentence_id": 0}
+{"abstract_id": "24322060", "label": "objective", "text": "OBJECTIVE To test whether the Communities That Care ( CTC ) prevention system reduced levels of risk and adolescent problem behaviors community wide @ years after implementation of CTC .", "sentence_id": 1}
+{"abstract_id": "24322060", "label": "methods", "text": "A community-randomized trial was performed in @ small towns in @ states , matched within state , assigned randomly to a control or intervention group in @ .", "sentence_id": 2}
+{"abstract_id": "24322060", "label": "methods", "text": "All fifth-grade students attending public schools in study communities in @-@ who received consent from their parents to participate ( @ % of the eligible population ) were included .", "sentence_id": 3}
+{"abstract_id": "24322060", "label": "methods", "text": "A panel of @ fifth graders was surveyed through @th grade , with @ % of the sample participating at the last follow-up .", "sentence_id": 4}
+{"abstract_id": "24322060", "label": "methods", "text": "A coalition of community stakeholders received training and technical assistance to install CTC , used epidemiologic data to identify elevated risk factors and depressed protective factors for adolescent problem behaviors in the community , and implemented tested and effective programs for youths aged @ to @ years as well as their families and schools to address their community 's elevated risks .", "sentence_id": 5}
+{"abstract_id": "24322060", "label": "methods", "text": "MAIN OUTCOMES AND MEASURES Levels of targeted risk ; sustained abstinence , and cumulative incidence by grade @ ; and current prevalence of tobacco , alcohol , and other drug use , delinquency , and violence in @th grade .", "sentence_id": 6}
+{"abstract_id": "24322060", "label": "results", "text": "By spring of @th grade , students in CTC communities were more likely than students in control communities to have abstained from any drug use ( adjusted risk ratio -LSB- ARR -RSB- = @ ; @ % CI , @-@ @ ) , drinking alcohol ( ARR = @ ; @ % CI , @-@ @ ) , smoking cigarettes ( ARR = @ ; @ % CI , @-@ @ ) , and engaging in delinquency ( ARR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24322060", "label": "results", "text": "They were also less likely to ever have committed a violent act ( ARR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24322060", "label": "results", "text": "There were no significant differences by intervention group in targeted risks , the prevalence of past-month or past-year substance use , or past-year delinquency or violence .", "sentence_id": 9}
+{"abstract_id": "24322060", "label": "conclusions", "text": "Using the CTC system continued to prevent the initiation of adolescent problem behaviors through @th grade , @ years after implementation of CTC and @ years after study-provided resources ended , but did not produce reductions in current levels of risk or current prevalence of problem behavior in @th grade .", "sentence_id": 10}
+{"abstract_id": "24322060", "label": "conclusions", "text": "TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT@ .", "sentence_id": 11}
+{"abstract_id": "24634923", "label": "objective", "text": "In some randomized controlled trials laparoscopic cholecystectomy ( LC ) for acute cholecystitis was associated with a shorter hospital stay when compared with open cholecystectomy ( OC ) .", "sentence_id": 0}
+{"abstract_id": "24634923", "label": "objective", "text": "These studies were not double blinded and without intention to treat purpose .", "sentence_id": 1}
+{"abstract_id": "24634923", "label": "methods", "text": "The present study project was a prospective , randomized investigation .", "sentence_id": 2}
+{"abstract_id": "24634923", "label": "methods", "text": "The study was performed in the Department of General , Emergency and Transplant Surgery St Orsola-Malpighi University Hospital ( Bologna , Italy ) .", "sentence_id": 3}
+{"abstract_id": "24634923", "label": "methods", "text": "Subjects were divided in two groups : in the first group the patient was submitted to LC while in the second group was submitted to OC .", "sentence_id": 4}
+{"abstract_id": "24634923", "label": "results", "text": "Of @ consecutive patients , @ were excluded from the study .", "sentence_id": 5}
+{"abstract_id": "24634923", "label": "results", "text": "The two groups were similar in demographic and clinical characteristics .", "sentence_id": 6}
+{"abstract_id": "24634923", "label": "results", "text": "Seven ( @ % ) patients in the LC group required conversion to OC .", "sentence_id": 7}
+{"abstract_id": "24634923", "label": "results", "text": "There were no deaths or bile duct lesions in either group , and the postoperative complication rate was similar ( p = n.s. ) .", "sentence_id": 8}
+{"abstract_id": "24634923", "label": "results", "text": "The mean postoperative hospital stay was also comparable .", "sentence_id": 9}
+{"abstract_id": "24634923", "label": "conclusions", "text": "Even though LC for acute and gangrenous cholecystitis is technically demanding , in experienced hands it is safe and effective .", "sentence_id": 10}
+{"abstract_id": "24634923", "label": "conclusions", "text": "It does not increase the mortality and the morbidity rate with a low conversion rate and no difference in hospital stay .", "sentence_id": 11}
+{"abstract_id": "24332577", "label": "background", "text": "The role of three factors in drinking outcome after brief intervention among heavily drinking HIV patients were investigated : strength of commitment to change drinking , alcohol dependence , and treatment type : brief Motivational Interview ( MI ) only , or MI plus HealthCall , a technological extension of brief intervention .", "sentence_id": 0}
+{"abstract_id": "24332577", "label": "methods", "text": "HIV primary care patients ( N = @ ) who drank @ drinks at least once in the @ days before study entry participated in MI-only or MI+H ealthCall in a randomized trial to reduce drinking .", "sentence_id": 1}
+{"abstract_id": "24332577", "label": "methods", "text": "Patients were @ % minority ; @ % female ; @ % alcohol dependent ; mean age @ .", "sentence_id": 2}
+{"abstract_id": "24332577", "label": "methods", "text": "Outcome at end of treatment ( @ days ) was drinks per drinking day ( Timeline Follow-Back ) .", "sentence_id": 3}
+{"abstract_id": "24332577", "label": "methods", "text": "Commitment strength ( CS ) was rated from MI session recordings .", "sentence_id": 4}
+{"abstract_id": "24332577", "label": "results", "text": "Overall , stronger CS predicted end-of-treatment drinking ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24332577", "label": "results", "text": "After finding an interaction of treatment , CS and alcohol dependence ( p = @ ) , we examined treatmentCS interactions in alcohol dependent and non-dependent patients .", "sentence_id": 6}
+{"abstract_id": "24332577", "label": "results", "text": "In alcohol dependent patients , the treatmentcommitment strength interaction was significant ( p = @ ) ; patients with low commitment strength had better outcomes in MI+H ealthCall than in MI-only ( lower mean drinks per drinking day ; @ and @ drinks , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24332577", "label": "results", "text": "In non-dependent patients , neither treatment nor CS predicted outcome .", "sentence_id": 8}
+{"abstract_id": "24332577", "label": "conclusions", "text": "Among alcohol dependent HIV patients , HealthCall was most beneficial in drinking reduction when MI ended with low commitment strength .", "sentence_id": 9}
+{"abstract_id": "24332577", "label": "conclusions", "text": "HealthCall may not merely extend MI effects , but add effects of its own that compensate for low commitment strength .", "sentence_id": 10}
+{"abstract_id": "24332577", "label": "conclusions", "text": "Thus , HealthCall may also be effective when paired with briefer interventions requiring less skill , training and supervision than MI .", "sentence_id": 11}
+{"abstract_id": "24332577", "label": "conclusions", "text": "Replication is warranted .", "sentence_id": 12}
+{"abstract_id": "24612164", "label": "objective", "text": "To evaluate the effectiveness of the Healthy School and Drugs programme on alcohol , tobacco and marijuana use among Dutch early adolescents .", "sentence_id": 0}
+{"abstract_id": "24612164", "label": "methods", "text": "Randomized clustered trial with two intervention conditions ( i.e. e-learning and integral ) .", "sentence_id": 1}
+{"abstract_id": "24612164", "label": "methods", "text": "General population of @-@-year-old adolescents in the Netherlands .", "sentence_id": 2}
+{"abstract_id": "24612164", "label": "methods", "text": "A total of @ students of @ Dutch secondary schools .", "sentence_id": 3}
+{"abstract_id": "24612164", "label": "methods", "text": "Structured digital questionnaires were administered pre-intervention and at @ months follow-up .", "sentence_id": 4}
+{"abstract_id": "24612164", "label": "methods", "text": "The primary outcome measures were new incidences of alcohol ( life-time and @-month prevalence ) , tobacco ( life-time and @-month prevalence ) and marijuana use ( life-time prevalence ) .", "sentence_id": 5}
+{"abstract_id": "24612164", "label": "results", "text": "Main effect analyses showed no programme effects on incidences of alcohol consumption ( life-time prevalence : e-learning condition : B = @ , P = @ ; integral condition : B = -@ , P = @ ; @-month prevalence : e-learning condition : B = @ , P = @ ; integral condition : B = -@ , P = @ ) , tobacco consumption ( life-time prevalence : e-learning condition : B = @ , P = @ ; integral condition : B = @ , P = @ ; @-month prevalence : e-learning condition : B = @ , P = @ ; integral condition : B = @ , P = @ ) , or marijuana consumption ( life-time prevalence : e-learning condition : B = @ , P = @ ; integral condition : B = @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24612164", "label": "conclusions", "text": "The non-significant impact of the Healthy School and Drugs programme ( a Dutch school-based prevention programme for early adolescents ) on incidences of alcohol , tobacco and marijuana use indicates that the programme is either ineffective or implemented inadequately .", "sentence_id": 7}
+{"abstract_id": "24767575", "label": "background", "text": "Esophageal resection is associated with a high incidence of postoperative pneumonia .", "sentence_id": 0}
+{"abstract_id": "24767575", "label": "background", "text": "Respiratory complications account for almost half of the readmissions to the critical care unit .", "sentence_id": 1}
+{"abstract_id": "24767575", "label": "background", "text": "Postoperative complications can result in prolonged hospital stay and consequently increase healthcare costs .", "sentence_id": 2}
+{"abstract_id": "24767575", "label": "background", "text": "In cardiac surgery a preoperative inspiratory muscle training program has shown to prevent postoperative pneumonia and reduce length of hospital stay .", "sentence_id": 3}
+{"abstract_id": "24767575", "label": "background", "text": "While in some surgical centers inspiratory muscle training is already used in the preoperative phase in patients undergoing esophageal resection , the added value of this intervention on the reduction of pulmonary complications has not yet been investigated in large surgical populations other than cardiac surgery in a randomized and controlled study design .", "sentence_id": 4}
+{"abstract_id": "24767575", "label": "methods", "text": "The effect of a preoperative inspiratory muscle training program on the incidence of postoperative pneumonia in patients undergoing esophageal resection will be studied in a single blind multicenter randomized controlled trial ( the PREPARE study ) .", "sentence_id": 5}
+{"abstract_id": "24767575", "label": "methods", "text": "In total @ patients ( age > @years ) undergoing esophageal resection for esophageal cancer will be included in this study .", "sentence_id": 6}
+{"abstract_id": "24767575", "label": "methods", "text": "They are randomized to either usual care or usual care with an additional inspiratory muscle training intervention according to a high-intensity protocol which is performed with a tapered flow resistive inspiratory loading device .", "sentence_id": 7}
+{"abstract_id": "24767575", "label": "methods", "text": "Patients have to complete @ dynamic inspiratory efforts twice daily for @days a week until surgery with a minimum of @weeks .", "sentence_id": 8}
+{"abstract_id": "24767575", "label": "methods", "text": "The starting training load will be aimed to be @ % of maximal inspiratory pressure and will be increased based on the rate of perceived exertion.The main study endpoint is the incidence of postoperative pneumonia .", "sentence_id": 9}
+{"abstract_id": "24767575", "label": "methods", "text": "Secondary objectives are to evaluate the effect of preoperative inspiratory muscle training on length of hospital stay , duration of mechanical ventilation , incidence of other postoperative ( pulmonary ) complications , quality of life , and on postoperative respiratory muscle function and lung function .", "sentence_id": 10}
+{"abstract_id": "24767575", "label": "conclusions", "text": "The PREPARE study is the first multicenter randomized controlled trial to evaluate the hypothesis that preoperative inspiratory muscle training leads to decreased pulmonary complications in patients undergoing esophageal resection .", "sentence_id": 11}
+{"abstract_id": "24957569", "label": "objective", "text": "Few data are available on the influence of a colonoscope length for trainees , which could affect both the duration of training and colonoscopy quality .", "sentence_id": 0}
+{"abstract_id": "24957569", "label": "objective", "text": "We conducted this study to validate which scope needs more duration for training to reach technical competence and to shows better quality indicators during diagnostic colonoscopy .", "sentence_id": 1}
+{"abstract_id": "24957569", "label": "methods", "text": "We conducted a prospective randomly assigned study from April @ to February @ at Asan Medical Center .", "sentence_id": 2}
+{"abstract_id": "24957569", "label": "methods", "text": "Among the @ patients enrolled , @ colonoscopies were analyzed .", "sentence_id": 3}
+{"abstract_id": "24957569", "label": "methods", "text": "We compared cecal intubation rate , adenoma detection rate , cecal intubation time ( < @ min ) , and withdrawal time between the trainees using the intermediate-length colonoscope and those using long-length colonoscope .", "sentence_id": 4}
+{"abstract_id": "24957569", "label": "results", "text": "Trainees who used the long-length colonoscope showed a higher overall cecal intubation rate ( @ % vs. @ % , p = @ ) and adenoma detection rate ( @ % vs. @ % , p < @ ) than those using the intermediate-length colonoscope .", "sentence_id": 5}
+{"abstract_id": "24957569", "label": "results", "text": "The successful cecal intubation rate improved significantly and reached the requisite standard of competence ( > @ % ) after @ procedures in the long-length colonoscope group .", "sentence_id": 6}
+{"abstract_id": "24957569", "label": "results", "text": "However , the trainees using the intermediate-length colonoscope reached the requisite standard of competence after @ procedures .", "sentence_id": 7}
+{"abstract_id": "24957569", "label": "results", "text": "Logistic regression analysis revealed that prolonged cecal intubation was associated with the use of the intermediate-length colonoscope , poor colon preparation , a small number of esophagastroduodenoscopy or sigmoidoscopy procedures conducted , and pain during procedures .", "sentence_id": 8}
+{"abstract_id": "24957569", "label": "conclusions", "text": "During the same training period , use of the long-length colonoscope in trainee was better in terms of reaching competency and quality indicators , and was less painful for the patients during colonoscopic procedures .", "sentence_id": 9}
+{"abstract_id": "24424076", "label": "objective", "text": "The current study was performed to investigate the effects of the Dietary Approaches to Stop Hypertension ( DASH ) eating plan on pregnancy outcomes in pregnant women with gestational diabetes mellitus ( GDM ) .", "sentence_id": 0}
+{"abstract_id": "24424076", "label": "methods", "text": "This randomized controlled clinical trial was performed among @ women diagnosed with GDM .", "sentence_id": 1}
+{"abstract_id": "24424076", "label": "methods", "text": "Participants were randomly assigned to consume either the control ( n = @ ) or the DASH diet ( n = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24424076", "label": "methods", "text": "The control diet was designed to contain @-@ % carbohydrates , @-@ % protein and @-@ % total fat .", "sentence_id": 3}
+{"abstract_id": "24424076", "label": "methods", "text": "The DASH diet was rich in fruits , vegetables , whole grains and low-fat dairy products , and contained lower amounts of saturated fats , cholesterol and refined grains with a total of @ mg/day sodium .", "sentence_id": 4}
+{"abstract_id": "24424076", "label": "methods", "text": "The numbers of women who commenced insulin therapy after dietary intervention , the mode of delivery and prevalence of polyhydramnios were assessed .", "sentence_id": 5}
+{"abstract_id": "24424076", "label": "methods", "text": "The length , weight and head circumference of infants were measured during the first @ h after birth .", "sentence_id": 6}
+{"abstract_id": "24424076", "label": "results", "text": "Whereas @ % of women in the DASH diet needed to have a cesarean section , this percentage for the control group was @ % ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24424076", "label": "results", "text": "The percentage of those who needed to commence insulin therapy after intervention was also significantly different between the two groups ( @ % for DASH vs @ % for control group , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24424076", "label": "results", "text": "Infants born to mothers on the DASH diet had significantly lower weight ( @ vs @ g , P < @ ) , head circumference ( @ vs @ cm , P = @ ) and ponderal index ( @ vs @ kg/m ( @ ) , P < @ ) compared with those born to mothers on the control diet .", "sentence_id": 9}
+{"abstract_id": "24424076", "label": "conclusions", "text": "In conclusion , consumption of DASH diet for @ weeks among pregnant women with GDM resulted in improved pregnancy outcomes .", "sentence_id": 10}
+{"abstract_id": "25111822", "label": "objective", "text": "Functional near-infrared spectroscopy ( fNIRS ) is an emerging technique for the in vivo assessment of functional activity of the cerebral cortex as well as in the field of brain-computer interface ( BCI ) research .", "sentence_id": 0}
+{"abstract_id": "25111822", "label": "objective", "text": "A common challenge for the utilization of fNIRS in these areas is a stable and reliable investigation of the spatio-temporal hemodynamic patterns .", "sentence_id": 1}
+{"abstract_id": "25111822", "label": "objective", "text": "However , the recorded patterns may be influenced and superimposed by signals generated from physiological processes , resulting in an inaccurate estimation of the cortical activity .", "sentence_id": 2}
+{"abstract_id": "25111822", "label": "objective", "text": "Up to now only a few studies have investigated these influences , and still less has been attempted to remove/reduce these influences .", "sentence_id": 3}
+{"abstract_id": "25111822", "label": "objective", "text": "The present study aims to gain insights into the reduction of physiological rhythms in hemodynamic signals ( oxygenated hemoglobin ( oxy-Hb ) , deoxygenated hemoglobin ( deoxy-Hb ) ) .", "sentence_id": 4}
+{"abstract_id": "25111822", "label": "methods", "text": "We introduce the use of three different signal processing approaches ( spatial filtering , a common average reference ( CAR ) method ; independent component analysis ( ICA ) ; and transfer function ( TF ) models ) to reduce the influence of respiratory and blood pressure ( BP ) rhythms on the hemodynamic responses .", "sentence_id": 5}
+{"abstract_id": "25111822", "label": "results", "text": "All approaches produce large reductions in BP and respiration influences on the oxy-Hb signals and , therefore , improve the contrast-to-noise ratio ( CNR ) .", "sentence_id": 6}
+{"abstract_id": "25111822", "label": "results", "text": "In contrast , for deoxy-Hb signals CAR and ICA did not improve the CNR .", "sentence_id": 7}
+{"abstract_id": "25111822", "label": "results", "text": "However , for the TF approach , a CNR-improvement in deoxy-Hb can also be found .", "sentence_id": 8}
+{"abstract_id": "25111822", "label": "conclusions", "text": "The present study investigates the application of different signal processing approaches to reduce the influences of physiological rhythms on the hemodynamic responses .", "sentence_id": 9}
+{"abstract_id": "25111822", "label": "conclusions", "text": "In addition to the identification of the best signal processing method , we also show the importance of noise reduction in fNIRS data .", "sentence_id": 10}
+{"abstract_id": "25782319", "label": "objective", "text": "To study effect of combined therapy with amlodipine with ramipril on the circadian profile of arterial pressure in patients with arterial hypertension in the Far North depending on the shiftwork regime .", "sentence_id": 0}
+{"abstract_id": "25782319", "label": "methods", "text": "@ patients with grade @-@ AH were divided into @ groups depending on the work-time schedule .", "sentence_id": 1}
+{"abstract_id": "25782319", "label": "methods", "text": "Group @ included @ daywork patients group @ consisted of @ patients working in the alternating daywork and nightwork regime .", "sentence_id": 2}
+{"abstract_id": "25782319", "label": "methods", "text": "@ hr AH monitoring was performed before , @ weeks and @ months after the onset of the study .", "sentence_id": 3}
+{"abstract_id": "25782319", "label": "results", "text": "Six months after the onset of therapy practically all patients reached the target AD level ( @ % in group @ and @ % in group ) .", "sentence_id": 4}
+{"abstract_id": "25782319", "label": "results", "text": "The patients fairly well tolerated therapy AD circadian profile was normalized @ times in group @ and @ times in group @ .", "sentence_id": 5}
+{"abstract_id": "25782319", "label": "results", "text": "Recovered AP variability in group @ resulted in a decreased frequency of target organ affection .", "sentence_id": 6}
+{"abstract_id": "25782319", "label": "results", "text": "In group @ , the initially higher variability accounted for the normalization of only diastolic AP variability after @ month therapy .", "sentence_id": 7}
+{"abstract_id": "25782319", "label": "results", "text": "It suggests the necessity of prescription of a third anti-AH preparation to these patients .", "sentence_id": 8}
+{"abstract_id": "25782319", "label": "results", "text": "Morning AP dynamics improved in both groups .", "sentence_id": 9}
+{"abstract_id": "24702612", "label": "objective", "text": "To ( @ ) develop a model of cyclical adduction force on an abducted left arytenoid cartilage that mimics swallowing or coughing ; ( @ ) determine if arytenoid abduction by a clamp before knot tying will improve the maintenance of abduction under cyclical adduction testing .", "sentence_id": 0}
+{"abstract_id": "24702612", "label": "methods", "text": "Experimental .", "sentence_id": 1}
+{"abstract_id": "24702612", "label": "methods", "text": "Cadaveric equine larynges ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24702612", "label": "methods", "text": "Left laryngoplasty performed using a single suture of # @ Ethibond with ( n = @ ) and without ( n = @ ) abducting the arytenoid with a clamp before knot tying .", "sentence_id": 3}
+{"abstract_id": "24702612", "label": "methods", "text": "Each laryngoplasty was loaded cyclically from @ to @N at @ Hz for @ cycles in a servohydraulic test frame .", "sentence_id": 4}
+{"abstract_id": "24702612", "label": "methods", "text": "Arytenoid displacement data were collected at @Hz intervals and median percent loss of abduction compared between groups .", "sentence_id": 5}
+{"abstract_id": "24702612", "label": "methods", "text": "Significance was set at P < @ .", "sentence_id": 6}
+{"abstract_id": "24702612", "label": "results", "text": "Median left arytenoid abduction distance was @ mm ( range , @-@ @ mm ) .", "sentence_id": 7}
+{"abstract_id": "24702612", "label": "results", "text": "One larynx in each group failed at < @ cycles .", "sentence_id": 8}
+{"abstract_id": "24702612", "label": "results", "text": "Loss of abduction was determined by progressive displacement of the testing actuator and confirmed by measurement .", "sentence_id": 9}
+{"abstract_id": "24702612", "label": "results", "text": "There was no difference in loss of abduction between clamped and non-clamped larynges after @ cycles .", "sentence_id": 10}
+{"abstract_id": "24702612", "label": "results", "text": "This model of cyclical adduction resulted in arytenoid displacements similar to those seen in the @st week postoperatively .", "sentence_id": 11}
+{"abstract_id": "24702612", "label": "conclusions", "text": "Ex vivo cyclical adductory forces produced a significant loss of laryngoplasty abduction .", "sentence_id": 12}
+{"abstract_id": "24702612", "label": "conclusions", "text": "The use of a clamp to abduct the arytenoid cartilage before knot tying did not reduce the loss of abduction .", "sentence_id": 13}
+{"abstract_id": "25226015", "label": "objective", "text": "To assess the potential efficacy , safety , and optimal dosing concentration of tavaborole , a novel , boron-based pharmaceutical agent with broad-spectrum antifungal activity , for the treatment of onychomycosis of the toenail due to dermatophytes .", "sentence_id": 0}
+{"abstract_id": "25226015", "label": "methods", "text": "One double-blind , randomized , vehicle-controlled study ( study @ ) and two open-label studies ( studies @ and @ ) examined the efficacy , safety , and optimal dosing concentration of tavaborole topical solution applied once daily or three times weekly for @ days at concentrations of @ % , @ % , @ % , or @ % .", "sentence_id": 1}
+{"abstract_id": "25226015", "label": "methods", "text": "Patient cohort @ of study @ received open-label tavaborole @ % once daily for @ days .", "sentence_id": 2}
+{"abstract_id": "25226015", "label": "methods", "text": "All three studies assessed day @ treatment success , defined as complete or partial clinical evidence of clear nail growth plus negative fungal culture .", "sentence_id": 3}
+{"abstract_id": "25226015", "label": "results", "text": "A total of @ patients were included in the intent-to-treat ( ITT ) or modified ITT populations and efficacy analyses across the @ studies .", "sentence_id": 4}
+{"abstract_id": "25226015", "label": "results", "text": "In study @ , treatment success rates at day @ were higher with tavaborole @ % , @ % , and @ % vs vehicle ( @ % , @ % , and @ % vs @ % , respectively ; slope P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25226015", "label": "results", "text": "In cohort @ of study @ , @ % of patients achieved treatment success with tavaborole @ % at day @ .", "sentence_id": 6}
+{"abstract_id": "25226015", "label": "results", "text": "Negative culture rates at day @ in study @ were numerically higher for tavaborole @ % , @ % , and @ % vs vehicle ( slope P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25226015", "label": "results", "text": "Application-site reactions of general irritation , erythema , scaling , and stinging/burning were most common with tavaborole @ % , were generally mild to moderate , and resolved with treatment discontinuation and/or a reduction in dosing frequency .", "sentence_id": 8}
+{"abstract_id": "25226015", "label": "results", "text": "No systemic safety concerns were observed .", "sentence_id": 9}
+{"abstract_id": "25226015", "label": "conclusions", "text": "Tavaborole solution demonstrated favorable efficacy and safety in phase @ clinical studies .", "sentence_id": 10}
+{"abstract_id": "25226015", "label": "conclusions", "text": "Based on these findings , tavaborole topical solution , @ % was further investigated in larger , more definitive phase @ studies .", "sentence_id": 11}
+{"abstract_id": "25226015", "label": "conclusions", "text": "Results from these completed phase @ studies will provide additional evidence regarding the safety and efficacy of tavaborole in the treatment of toenail onychomycosis .", "sentence_id": 12}
+{"abstract_id": "24650164", "label": "background", "text": "Evidence about long-term effects of preventive health services for youth with complex needs is lacking .", "sentence_id": 0}
+{"abstract_id": "24650164", "label": "background", "text": "Prime Time , a youth development intervention , aims to reduce pregnancy risk among vulnerable adolescent females seeking clinic services .", "sentence_id": 1}
+{"abstract_id": "24650164", "label": "methods", "text": "In a randomized trial , @ sexually active females aged @-@ who were at high risk for pregnancy were assigned to the Prime Time intervention or usual clinic services .", "sentence_id": 2}
+{"abstract_id": "24650164", "label": "methods", "text": "The @-month intervention , initiated in @-@ , comprised regular meetings with case managers and participation in youth leadership groups .", "sentence_id": 3}
+{"abstract_id": "24650164", "label": "methods", "text": "Trial participants completed surveys at baseline and @ months .", "sentence_id": 4}
+{"abstract_id": "24650164", "label": "methods", "text": "Regression analyses were used to evaluate differences between groups in sexual and psychosocial outcomes at follow-up .", "sentence_id": 5}
+{"abstract_id": "24650164", "label": "results", "text": "At @ months , the intervention group reported more months of consistent condom use ( adjusted means , @ vs. @ ) and dual contraceptive use ( @ vs. @ ) in the past seven months than did controls .", "sentence_id": 6}
+{"abstract_id": "24650164", "label": "results", "text": "The intervention was most effective in promoting consistent use among participants with relatively high levels of connectedness to family or school .", "sentence_id": 7}
+{"abstract_id": "24650164", "label": "results", "text": "Fifteen percent of intervention participants , but only @ % of controls , reported having abstained from sex in the past six months ( adjusted odds ratio , @ ) .", "sentence_id": 8}
+{"abstract_id": "24650164", "label": "results", "text": "Moreover , among high school graduates , those in the intervention group were more likely than those in the control group to have enrolled in college or technical school ( @ % vs. @ % ; odds ratio , @ ) .", "sentence_id": 9}
+{"abstract_id": "24650164", "label": "conclusions", "text": "Health services grounded in a youth development framework can lead to reductions in sexual risk among vulnerable youth that are evident one year following conclusion of services .", "sentence_id": 10}
+{"abstract_id": "24786016", "label": "objective", "text": "We aimed to investigate the population pharmacokinetics ( PK ) of soluble recombinant human tumor necrosis factor receptor fusion protein ( rhTNFR - Fc ) in Chinese patients with rheumatic arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "24786016", "label": "objective", "text": "The PK differences between Chinese patients with RA and healthy Chinese subjects were also compared .", "sentence_id": 1}
+{"abstract_id": "24786016", "label": "methods", "text": "@ patients were randomized to a single subcutaneous ( SC ) injections of @ mg ( n = @ ) , @ mg ( n = @ ) , and @ mg ( n = @ ) of rhTNFR-Fc , and six SC injection of rhTNFR - Fc at @ mg once in @ days ( n = @ ) respectively .", "sentence_id": 2}
+{"abstract_id": "24786016", "label": "methods", "text": "A total of @ serum concentration data points were collected in the RA patients .", "sentence_id": 3}
+{"abstract_id": "24786016", "label": "methods", "text": "The population PK analysis was performed by NONMEM .", "sentence_id": 4}
+{"abstract_id": "24786016", "label": "methods", "text": "Based on the population PK parameters obtained herein and those reported in healthy Chinese subjects , simulation was conducted to compare the difference of rhTNFR-Fc exposure between these populations .", "sentence_id": 5}
+{"abstract_id": "24786016", "label": "results", "text": "The PK data of Chinese patients with RA were best described by a one compartment model with lag time .", "sentence_id": 6}
+{"abstract_id": "24786016", "label": "results", "text": "A higher CL/F was noted in RA patients compared with that of the healthy Chinese subjects ( @ L/h vs. @ L/h ) , and a lower Ka was noticed in the RA patients compared with that of the healthy subjects ( @ h-@ vs. @ h-@ ) .", "sentence_id": 7}
+{"abstract_id": "24786016", "label": "results", "text": "The simulate results showed that rhTNFR-Fc exposure in Chinese patients with RA was significantly lower than that in healthy subjects .", "sentence_id": 8}
+{"abstract_id": "24786016", "label": "results", "text": "The mean patients/healthy subjects C ( max ) and AUC ( ss ) ratios were @ and @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24786016", "label": "conclusions", "text": "A population PK model of rhTNFR - Fc was developed in Chinese patients with RA .", "sentence_id": 10}
+{"abstract_id": "24786016", "label": "conclusions", "text": "Statistical difference was noted in the PK of rhTNFR-Fc between Chinese patients with RA and healthy Chinese subjects .", "sentence_id": 11}
+{"abstract_id": "25063041", "label": "background", "text": "Korean red ginseng ( KRG ) is a processed ginseng from raw ginseng to enhance safety , preservation and efficacy , known having beneficial effects on women 's health due to its estrogen like function .", "sentence_id": 0}
+{"abstract_id": "25063041", "label": "background", "text": "While estrogen supplementation showed some modulation of endocrine disrupting chemicals , bisphenol A ( BPA ) has been focused as a potential endocrine disrupting chemical .", "sentence_id": 1}
+{"abstract_id": "25063041", "label": "background", "text": "In this study , we examined the efficacy and safety outcomes of KRG against BPA , focusing on female quality of life ( QOL ) .", "sentence_id": 2}
+{"abstract_id": "25063041", "label": "background", "text": "Individual variations in susceptibility to KRG were also investigated with the Sasang Typology , the personalized medicine used for hundred years in Korea .", "sentence_id": 3}
+{"abstract_id": "25063041", "label": "methods", "text": "We performed a single-blind randomized clinical trial .", "sentence_id": 4}
+{"abstract_id": "25063041", "label": "methods", "text": "Study subjects were young women ( N = @ ) , consumed @ g of KRG or placebo per day for @ weeks and filled up questionnaires regarding gynecologic complaints at the @ time spots .", "sentence_id": 5}
+{"abstract_id": "25063041", "label": "methods", "text": "We analyzed urinary total BPA and malondialdehyde ( MDA ) , an oxidative stress biomarker , with GC/MS and HPLC/UVD respectively , and diagnosed their Sasang Typology with the questionnaire for the Sasang constitution Classification ( QSCC II ) .", "sentence_id": 6}
+{"abstract_id": "25063041", "label": "results", "text": "KRG consumption decreased urinary BPA and MDA levels ( ps < @ ) and alleviated ` menstrual irregularity ' , ` menstrual pain ' , and ` constipation ' ( ps < @ ) .", "sentence_id": 7}
+{"abstract_id": "25063041", "label": "results", "text": "SoEum type ( Lesser Yin person ) among the Sasang types showed significant alleviation in insomnia , flushing , perspiration and appetite by KRG consumption , rather than other Sasang types .", "sentence_id": 8}
+{"abstract_id": "25063041", "label": "results", "text": "During the intervention , no one experienced any aggravated side effects .", "sentence_id": 9}
+{"abstract_id": "25063041", "label": "conclusions", "text": "We suggest KRG is efficient for protection for female QOL and BPA - exposure and - related oxidative stress .", "sentence_id": 10}
+{"abstract_id": "25063041", "label": "conclusions", "text": "However , individual variation in susceptibility to KRG should be further considered for identifying ideal therapy .", "sentence_id": 11}
+{"abstract_id": "24939366", "label": "objective", "text": "Conventional total uncinectomy may be unnecessary in localized maxillary sinus lesion .", "sentence_id": 0}
+{"abstract_id": "24939366", "label": "objective", "text": "Partial removal of the uncinate process and middle meatal antrostomy would be sufficient to eradicate the pathological condition .", "sentence_id": 1}
+{"abstract_id": "24939366", "label": "objective", "text": "Therefore , we aimed to evaluate the efficacy of partial uncinectomy versus total removal of the uncinate process in patients with localized maxillary sinus disease .", "sentence_id": 2}
+{"abstract_id": "24939366", "label": "methods", "text": "In total , @ patients were assigned randomly to partial and total uncinectomy groups .", "sentence_id": 3}
+{"abstract_id": "24939366", "label": "methods", "text": "Preoperative computed tomography established that all patients had localized pathology in the maxillary sinus .", "sentence_id": 4}
+{"abstract_id": "24939366", "label": "methods", "text": "The lower half of the uncinate process was removed in the partial uncinectomy group , while the total uncinectomy group underwent the conventional surgery .", "sentence_id": 5}
+{"abstract_id": "24939366", "label": "methods", "text": "Time required for the uncinectomy , healing period for the uncinectomy site , incidence of lamina papyracea or nasolacrimal duct injury , obstruction or stenosis of the frontal recess , and incidence of synechia formation in the middle meatus were compared between the groups .", "sentence_id": 6}
+{"abstract_id": "24939366", "label": "results", "text": "All patients completed the follow-up and were included in the analysis .", "sentence_id": 7}
+{"abstract_id": "24939366", "label": "results", "text": "Surgical indications included chronic maxillary sinusitis , fungal sinusitis , antrochoanal polyp , and odontogenic sinusitis .", "sentence_id": 8}
+{"abstract_id": "24939366", "label": "results", "text": "Operation durations and healing periods were significantly shorter in the partial uncinectomy group .", "sentence_id": 9}
+{"abstract_id": "24939366", "label": "results", "text": "One patient had a minor injury to the lamina papyracea and two patients showed partial synechia formations in the total uncinectomy group .", "sentence_id": 10}
+{"abstract_id": "24939366", "label": "results", "text": "However , other parameters did not differ significantly between the groups .", "sentence_id": 11}
+{"abstract_id": "24939366", "label": "conclusions", "text": "Partial uncinectomy may be useful in patients with pathological conditions confined to the maxillary sinus .", "sentence_id": 12}
+{"abstract_id": "24939366", "label": "conclusions", "text": "Shorter operation duration , more rapid healing , and lower incidence of complications are advantages over a conventional total uncinectomy .", "sentence_id": 13}
+{"abstract_id": "25012765", "label": "background", "text": "Cumulative evidence from epidemiological , preclinical and clinical studies suggests estrogens may have psychoprotective effects in schizophrenic patients .", "sentence_id": 0}
+{"abstract_id": "25012765", "label": "background", "text": "Selective Estrogen Receptor Modulators could have therapeutic benefits in schizophrenia for both sexes without being hazardous to gynecological tissues or having feminizing effects .", "sentence_id": 1}
+{"abstract_id": "25012765", "label": "background", "text": "Few studies have been conducted regarding the effects of raloxifene on postmenopausal women suffering from schizophrenia .", "sentence_id": 2}
+{"abstract_id": "25012765", "label": "background", "text": "We conducted this placebo-controlled trial to compare the add-on effect of raloxifene to risperidone versus risperidone with placebo .", "sentence_id": 3}
+{"abstract_id": "25012765", "label": "methods", "text": "This was an @-week , parallel-group , placebo-controlled trial undertaken at two universities affiliated psychiatric Hospitals in Iran .", "sentence_id": 4}
+{"abstract_id": "25012765", "label": "methods", "text": "Forty-six postmenopausal women with the definite diagnosis of schizophrenia were enrolled in the study .", "sentence_id": 5}
+{"abstract_id": "25012765", "label": "methods", "text": "Patients received risperidone ( @ mg/day in @ divided doses ) combined with either placebo ( N = @ ) or @ mg/day of raloxifene ( N = @ ) for @ weeks .", "sentence_id": 6}
+{"abstract_id": "25012765", "label": "methods", "text": "Patients were assessed by a psychiatrist at baseline and at @ and @ weeks after the start of medical therapy .", "sentence_id": 7}
+{"abstract_id": "25012765", "label": "methods", "text": "Efficacy was defined as the change from baseline to endpoint in score on Positive and Negative Syndrome Scale ( PANSS ) .", "sentence_id": 8}
+{"abstract_id": "25012765", "label": "results", "text": "For PANSS scores , the main effect comparing two types of intervention was not significant -LSB- F ( @ , @ ) = @ , p = @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "25012765", "label": "results", "text": "For positive subscale scores , there was marginal significant interaction between intervention type and time -LSB- F ( @ , @ ) = @ , p = @ -RSB- and there was substantial main effect for time -LSB- F ( @ , @ ) = @ , p = @ -RSB- within both groups showing reduction in positive subscale scores across the three time periods .", "sentence_id": 10}
+{"abstract_id": "25012765", "label": "results", "text": "In addition , the main effect comparing two types of intervention was significant -LSB- F ( @ , @ ) = @ , p = @ -RSB- .", "sentence_id": 11}
+{"abstract_id": "25012765", "label": "results", "text": "On the other hand , for negative subscale scores , the main effect comparing two types of intervention was not significant -LSB- F ( @ , @ ) = @ , p = @ -RSB- .", "sentence_id": 12}
+{"abstract_id": "25012765", "label": "results", "text": "For general subscale scores , the main effect comparing two types of intervention was not significant -LSB- F ( @ , @ ) = @ , p = @ -RSB- .", "sentence_id": 13}
+{"abstract_id": "25012765", "label": "conclusions", "text": "According to our findings , raloxifene as an adjunctive treatment to risperidone was only superior in improvement of positive symptoms and it was not effective in treating negative and general psychopathology symptoms .", "sentence_id": 14}
+{"abstract_id": "24737198", "label": "objective", "text": "We investigated the long-term effects of repetitive transcranial magnetic stimulation ( rTMS ) delivered to the temporoparietal junction and compared contralateral and ipsilateral application in patients with unilateral tinnitus .", "sentence_id": 0}
+{"abstract_id": "24737198", "label": "methods", "text": "Prospective study .", "sentence_id": 1}
+{"abstract_id": "24737198", "label": "methods", "text": "A total of @ patients with asymmetric hearing loss and nonpulsatile chronic tinnitus localized to the poorer ear who were refractory to medical treatment were enrolled .", "sentence_id": 2}
+{"abstract_id": "24737198", "label": "methods", "text": "Patients were randomly assigned to one of two treatment groups : @-Hz stimulation applied to the temporoparietal junction either ipsilaterally ( n = @ ) or contralaterally ( n = @ ) to the symptomatic ear .", "sentence_id": 3}
+{"abstract_id": "24737198", "label": "methods", "text": "Changes in the Tinnitus Handicap Inventory ( THI ) scores and self-rating visual analog scores ( VAS ) for loudness , awareness , and annoyance were analyzed before and after treatment for @ months .", "sentence_id": 4}
+{"abstract_id": "24737198", "label": "methods", "text": "Improved patients were defined as those with decreases in their THI scores by > @ points and @ % .", "sentence_id": 5}
+{"abstract_id": "24737198", "label": "results", "text": "There were no major complications or worsening of hearing .", "sentence_id": 6}
+{"abstract_id": "24737198", "label": "results", "text": "When analyzing the THI scores and VAS pre-rTMS and @ months after rTMS , significant decreases were observed in patients overall ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24737198", "label": "results", "text": "For the comparison of long-term outcomes between the ipsilateral and contralateral stimulation groups , there were no differences in the degree of decrease in THI scores or VAS ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24737198", "label": "results", "text": "In addition , there was no significant difference in the rate of patients who improved between the ipsilateral ( @ of @ ) and contralateral ( @ of @ ) stimulation groups ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24737198", "label": "results", "text": "The ipsilateral group showed a more rapid improvement than the contralateral group .", "sentence_id": 10}
+{"abstract_id": "24737198", "label": "conclusions", "text": "Daily application of @-Hz rTMS to the temporoparietal area is safe and has long-term beneficial effects .", "sentence_id": 11}
+{"abstract_id": "24737198", "label": "conclusions", "text": "The laterality of stimulation is not the decisive factor .", "sentence_id": 12}
+{"abstract_id": "25145581", "label": "background", "text": "A prospective endoscopic and radiologic evaluation of long-term outcomes of crushing and crushing with intrinsic stripping , @ minimally destructive techniques used for the surgical treatment of concha bullosa .", "sentence_id": 0}
+{"abstract_id": "25145581", "label": "methods", "text": "Forty-two patients who underwent concha bullosa surgery ( a total of @ conchae surgeries ) were included in the study .", "sentence_id": 1}
+{"abstract_id": "25145581", "label": "methods", "text": "The patients were allocated consecutively to either of the @ groups : Group @ ( crushing , n = @ ) and Group @ ( crushing with intrinsic stripping , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25145581", "label": "methods", "text": "All procedures were performed endoscopically .", "sentence_id": 3}
+{"abstract_id": "25145581", "label": "methods", "text": "The presurgical and @-year postsurgical endoscopic nasal cavity images and computed tomography ( CT ) scans of all patients were recorded .", "sentence_id": 4}
+{"abstract_id": "25145581", "label": "methods", "text": "Preoperative and postoperative measurements were compared using paired t test and Student t test .", "sentence_id": 5}
+{"abstract_id": "25145581", "label": "results", "text": "Gender and mean age of the @ patients ( @ conchae bullosa ) were as follows : @ males , mean age @ ( range , @ to @ ) years ; @ females , mean age @ ( range , @ to @ ) years .", "sentence_id": 6}
+{"abstract_id": "25145581", "label": "results", "text": "The patients were followed for @ @ months .", "sentence_id": 7}
+{"abstract_id": "25145581", "label": "results", "text": "Comparisons of both the grading of endoscopic images and the concha bullosa volumes measured in CT images before and after treatment showed significant postsurgical reductions in both groups ; comparison between groups showed significant postsurgical decreases for Group @ in both concha bullosa volumes and in endoscopic scoring ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25145581", "label": "conclusions", "text": "Crushing with intrinsic stripping is an effective and easy technique ; when compared to crushing alone ; this technique provides a significantly more decrease in middle concha volumes as demonstrated both by the CT and by endoscopic evaluations .", "sentence_id": 9}
+{"abstract_id": "25363099", "label": "objective", "text": "The premenstrual syndrome ( PMS ) is a series of physical , mental , and behavioral symptoms with various severities , and disturbs social and personal relationships .", "sentence_id": 0}
+{"abstract_id": "25363099", "label": "objective", "text": "The syndrome appears during luteal phase of the menstrual cycle and is a common disorder of reproductive age .", "sentence_id": 1}
+{"abstract_id": "25363099", "label": "objective", "text": "Different treatments have been introduced for the syndrome due to its unknown complicated causes .", "sentence_id": 2}
+{"abstract_id": "25363099", "label": "objective", "text": "Vitamin B@ ( Thiamin ) may reduce symptoms of the syndrome through affecting the performance of coenzymes in the metabolism of carbohydrates and main branch of amino acid that plays an important role in appearance of physical and mental symptoms of the PMS .", "sentence_id": 3}
+{"abstract_id": "25363099", "label": "objective", "text": "Vitamin B@ is the first water-soluble discovered vitamin .", "sentence_id": 4}
+{"abstract_id": "25363099", "label": "objective", "text": "As it is effective in neural activity and muscle tonus in different body activities , including hematopoiesis , metabolism of carbohydrates , activities of the central nervous system and neuromuscular system , etc. , it can be effective in this dysmenorrhea that is a disorder resulting from uterine muscular contraction .", "sentence_id": 5}
+{"abstract_id": "25363099", "label": "objective", "text": "There are no enough studies and research on the effect of vitamin B@ on the symptoms of PMS , therefore , this study was conducted to determine the effect of vitamin B@ on the symptoms of PMS in students residing at dormitories of Jahrom University of Medical Sciences in @ .", "sentence_id": 6}
+{"abstract_id": "25363099", "label": "methods", "text": "In this double-blind placebo-controlled clinical trial , @ students with PMS residing at dormitories of Jahrom University of Medical Sciences were divided randomly into two groups , vitamin B@ and placebo .", "sentence_id": 7}
+{"abstract_id": "25363099", "label": "methods", "text": "The severity of the symptoms of PMS in two cycles , before the intervention and during the intervention , was recorded by the students .", "sentence_id": 8}
+{"abstract_id": "25363099", "label": "methods", "text": "The data were collected using an information collection form , PMS provisional diagnosis form , daily status record form , Beck Depression Inventory .", "sentence_id": 9}
+{"abstract_id": "25363099", "label": "methods", "text": "The data were analyzed using descriptive and inferential statistics .", "sentence_id": 10}
+{"abstract_id": "25363099", "label": "results", "text": "There was no significant difference among the studied variables in terms of confounding variables .", "sentence_id": 11}
+{"abstract_id": "25363099", "label": "results", "text": "The comparison of vitamin B@ group before the intervention with that after the intervention showed that vitamin B@ reduced mean mental ( @ % ) and physical ( @ % ) symptoms significantly ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25363099", "label": "results", "text": "Moreover , there was a significant difference between vitamin B@ and placebo groups in terms of mean mental and physical symptoms , as mean symptoms in vitamin B@ group was significantly lower than that in the placebo group ( P < @ ) .", "sentence_id": 13}
+{"abstract_id": "25363099", "label": "conclusions", "text": "It seems that vitamin B@ is effective in recovery of mental and physical symptoms of PMS .", "sentence_id": 14}
+{"abstract_id": "25363099", "label": "conclusions", "text": "Therefore , this vitamin can be used to reach a major goal of midwifery , that is , reduction of symptom severity of PMS , without any side effects .", "sentence_id": 15}
+{"abstract_id": "24839984", "label": "background", "text": "Chronic venous leg ulcers ( CVU ) are a common , unresolved medical problem .", "sentence_id": 0}
+{"abstract_id": "24839984", "label": "background", "text": "Silica gel fibre ( SGF ) is a novel biodegradable inorganic material developed to serve as a carrier substrate for the local release of pharmaceutical agents facilitating tissue repair .", "sentence_id": 1}
+{"abstract_id": "24839984", "label": "objective", "text": "To assess the performance and safety of SGF in subjects with CVU .", "sentence_id": 2}
+{"abstract_id": "24839984", "label": "methods", "text": "Open , randomized , standard-of-care-controlled , multi-centre trial .", "sentence_id": 3}
+{"abstract_id": "24839984", "label": "methods", "text": "Subjects ( ITT @ patients ) received either SGF in addition to standard treatment or standard-of-care treatment ( S-o-C ) alone .", "sentence_id": 4}
+{"abstract_id": "24839984", "label": "methods", "text": "The primary performance variable was the time to healing of the target ulcer until the end of a @ week treatment period .", "sentence_id": 5}
+{"abstract_id": "24839984", "label": "results", "text": "SGF was well tolerated .", "sentence_id": 6}
+{"abstract_id": "24839984", "label": "results", "text": "Mean time to healing up to week @ was @ days for the SGF group ( SE @ ) and @ days for the S-o-C group ( SE @ ) ( p-value = @ ) .", "sentence_id": 7}
+{"abstract_id": "24839984", "label": "results", "text": "There was no statistically relevant difference regarding the incidence of complete healing of the target ulcers by weeks @ and @ between the SGF and the S-o-C groups ( p-value > @ ) .", "sentence_id": 8}
+{"abstract_id": "24839984", "label": "conclusions", "text": "SGF is well tolerated and offers a promising perspective as a carrier substrate for the local release of active pharmaceutical agents into the wound site to promote tissue repair .", "sentence_id": 9}
+{"abstract_id": "25045152", "label": "methods", "text": "Genistein from foods or supplements is metabolized by the gut microbiota and the human body , thereby releasing many different metabolites into systemic circulation .", "sentence_id": 0}
+{"abstract_id": "25045152", "label": "methods", "text": "The order of their appearance in plasma and the possible influence of food format are still unknown .", "sentence_id": 1}
+{"abstract_id": "25045152", "label": "methods", "text": "This study compared the nutrikinetic profiles of genistein metabolites .", "sentence_id": 2}
+{"abstract_id": "25045152", "label": "results", "text": "In a randomized cross-over trial , @ healthy young volunteers were administered a single dose of @ mg genistein provided as a genistein tablet , a genistein tablet in low fat milk , and soy milk containing genistein glycosides .", "sentence_id": 3}
+{"abstract_id": "25045152", "label": "results", "text": "A high mass resolution LC-LTQ-Orbitrap FTMS platform detected and quantified in human plasma : free genistein , seven of its phase-II metabolites and @ gut-derived metabolites .", "sentence_id": 4}
+{"abstract_id": "25045152", "label": "results", "text": "Interestingly , a novel metabolite , genistein-@ ' - glucuronide-@-sulfate ( G-@ ` G-@S ) was identified .", "sentence_id": 5}
+{"abstract_id": "25045152", "label": "results", "text": "Nutrikinetic analysis using population-based modeling revealed the order of appearance of five genistein phase II metabolites in plasma : ( @ ) genistein-@ ' ,@ - diglucuronide , ( @ ) genistein-@-sulfate , ( @ ) genistein-@ ' - sulfate-@-glucuronide , ( @ ) genistein-@ ' - glucuronide , and ( @ ) genistein-@-glucuronide , independent of the food matrix .", "sentence_id": 6}
+{"abstract_id": "25045152", "label": "conclusions", "text": "The conjugated genistein metabolites appear in a distinct order in human plasma .", "sentence_id": 7}
+{"abstract_id": "25045152", "label": "conclusions", "text": "The specific early appearance of G-@ ' ,@ - diG suggests a multistep formation process for the mono and hetero genistein conjugates , involving one or two deglucuronidation steps .", "sentence_id": 8}
+{"abstract_id": "24395492", "label": "background", "text": "Charcot-Marie-Tooth ( CMT ) disease type @A is the most common form of CMT .", "sentence_id": 0}
+{"abstract_id": "24395492", "label": "background", "text": "The main clinical features are distal weakness , sensory loss , and skeletal deformities .", "sentence_id": 1}
+{"abstract_id": "24395492", "label": "background", "text": "Although pain is a frequent complaint , small fiber involvement in CMT@A has not been studied extensively .", "sentence_id": 2}
+{"abstract_id": "24395492", "label": "methods", "text": "We assessed pain and small fiber involvement in @ CMT@A patients using a variety of pain scales , pain questionnaires , and thermal thresholds .", "sentence_id": 3}
+{"abstract_id": "24395492", "label": "results", "text": "Forty-three of @ patients ( @ % ) complained of pain .", "sentence_id": 4}
+{"abstract_id": "24395492", "label": "results", "text": "The pain was localized to the feet in @ % of patients .", "sentence_id": 5}
+{"abstract_id": "24395492", "label": "results", "text": "Only @ % of patients had neuropathic pain .", "sentence_id": 6}
+{"abstract_id": "24395492", "label": "results", "text": "Cold and warm detection thresholds were elevated in @ % and @ % of patients , respectively .", "sentence_id": 7}
+{"abstract_id": "24395492", "label": "conclusions", "text": "Our findings confirm that CMT@A patients have significant pain , which is more likely to be multifactorial in origin and suggests that a proportion of patients have small fiber dysfunction affecting mainly thinly myelinated A fibers .", "sentence_id": 8}
+{"abstract_id": "24350936", "label": "background", "text": "Metformin monotherapy is recommended as initial treatment of type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24350936", "label": "background", "text": "The selection of optimal second-line therapy that is often necessary due to the progressive nature of the disease is still a subject of ongoing discussions .", "sentence_id": 1}
+{"abstract_id": "24350936", "label": "objective", "text": "The aim of the international EDGE ( Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin ) study was to prospectively compare the efficacy and safety of vildagliptin vs other oral antidiabetic agents in patients with type @ diabetes not adequately controlled on monotherapy in a real-life clinical setting .", "sentence_id": 2}
+{"abstract_id": "24350936", "label": "objective", "text": "In this paper , we present the data of patients participating in the EDGE study in the Czech Republic .", "sentence_id": 3}
+{"abstract_id": "24350936", "label": "methods", "text": "Patients with type @ diabetes not adequately controlled on monotherapy were enrolled into the study , and randomised into either the vildagliptin arm or control arm with another OAD at the discretion of the treating physician .", "sentence_id": 4}
+{"abstract_id": "24350936", "label": "methods", "text": "Patients with the addition of other incretin-based medications were not enrolled into the study .", "sentence_id": 5}
+{"abstract_id": "24350936", "label": "methods", "text": "The efficiency was evaluated as a proportion of patients reaching the combined endpoint of decreasing HbA@c > @ mmol/mol without hypoglycaemia , peripheral oedema or treatment termination due to gastrointestinal side effects during the @ months of treatment .", "sentence_id": 6}
+{"abstract_id": "24350936", "label": "results", "text": "@ patients were enrolled into the study in the Czech Republic .", "sentence_id": 7}
+{"abstract_id": "24350936", "label": "results", "text": "The mean age of the patients when enrolled into the study ( vildagliptin group vs control group ) was @ @ vs @ @ years , mean body mass index was @ @ vs @ @ kg/m@ , mean HbA@c was @ @ vs @ @ mmol/mol .", "sentence_id": 8}
+{"abstract_id": "24350936", "label": "results", "text": "The probability of reaching the combined primary endpoint ( calculated using a binary logistic regression model to calculate the odds ratios with @ % confidence intervals ) was higher for vildagliptin regardless of baseline HbA@c or type of medication added in the control group .", "sentence_id": 9}
+{"abstract_id": "24350936", "label": "results", "text": "Primary endpoint was reached by @ % of patients in the vildagliptin group vs @ % of patients in the control group , odds ratio @ ( @ , @ ) ; p < @ .", "sentence_id": 10}
+{"abstract_id": "24350936", "label": "results", "text": "The proportion of patients reaching secondary endpoint ( HbA@c < @ mmol/mol without hypoglycemic event or weight gain @ % with baseline glycated hemoglobin > @ mmol/mol was higher for vildagliptin @ % vs @ % in the control arm , odds ratio @ ( @ , @ ) , p < @ .", "sentence_id": 11}
+{"abstract_id": "24350936", "label": "results", "text": "The rate of adverse events was comparable in both groups .", "sentence_id": 12}
+{"abstract_id": "24350936", "label": "conclusions", "text": "In a real-life clinical set-ting , the percentage of patients reaching the combined endpoint of decreasing HbA@c > @ mmol/mol , without hypoglycaemia , peripheral oedema or treatment termination due to gastrointestinal side effects was higher after the addition of vildagliptin as compared to other antidiabetic agents with comparable rate of side effects .", "sentence_id": 13}
+{"abstract_id": "25426896", "label": "objective", "text": "To evaluate the effect of ozonated oil on palatal wounds .", "sentence_id": 0}
+{"abstract_id": "25426896", "label": "methods", "text": "Eighteen patients were randomized and allocated to either the ozone group ( n = @ ) or control ( n = @ ) group .", "sentence_id": 1}
+{"abstract_id": "25426896", "label": "methods", "text": "Free gingival graft surgery was performed , and post-harvested palatal wounds were treated with either @ mL ozonated oil or control oil daily for @ week .", "sentence_id": 2}
+{"abstract_id": "25426896", "label": "methods", "text": "A planimetrical analysis analyzed the digital image for the wound sizes and shape factor at baseline , at @ h , and days @ , @ , @ , @ , and @ , postoperatively .", "sentence_id": 3}
+{"abstract_id": "25426896", "label": "methods", "text": "A cytological analysis used the keratinization and superficial cell indices at baseline , @ h , and days @ , @ , @ , and @ and the second and third months , postoperatively .", "sentence_id": 4}
+{"abstract_id": "25426896", "label": "results", "text": "Planimetrical results showed a significant ( P @ ) improvement in wound size on days @ , @ , @ , @ , and @ , postoperatively , in the ozone group compared to the control group .", "sentence_id": 5}
+{"abstract_id": "25426896", "label": "results", "text": "Cytological results showed a significant ( P @ ) improvement in epithelial healing on days @ , @ , and @ , and the second and third months , postoperatively , after the application of ozonated oil compared to control oil .", "sentence_id": 6}
+{"abstract_id": "25426896", "label": "conclusions", "text": "Our results showed significant improvement in wound size and epithelial healing after topical ozonated oil application compared to control oil on palatal wounds .", "sentence_id": 7}
+{"abstract_id": "25650633", "label": "objective", "text": "The comparative incidences of hemidiaphragmatic paralysis associated with contemporary ultrasound-guided supraclavicular versus infraclavicular blockade have not received extensive study .", "sentence_id": 0}
+{"abstract_id": "25650633", "label": "objective", "text": "We tested the hypothesis that the infraclavicular approach results in a lower incidence of hemidiaphragmatic paralysis compared with supraclavicular blockade when a standard local anesthetic volume and concentration are used .", "sentence_id": 1}
+{"abstract_id": "25650633", "label": "methods", "text": "With institutional human ethics board approval , we enrolled @ patients undergoing right-sided upper extremity surgery in a randomized , blinded , parallel-group trial .", "sentence_id": 2}
+{"abstract_id": "25650633", "label": "methods", "text": "Patients were assigned to ultrasound-guided supraclavicular or infraclavicular blockade with @ mL of @ % ropivacaine .", "sentence_id": 3}
+{"abstract_id": "25650633", "label": "methods", "text": "The primary end point was complete hemidiaphragmatic paralysis at @ minutes , defined as a greater than @ % reduction in diaphragmatic excursion measured with the voluntary sniff test using M-mode ultrasonography .", "sentence_id": 4}
+{"abstract_id": "25650633", "label": "methods", "text": "Partial paralysis was defined as a @ % to @ % reduction .", "sentence_id": 5}
+{"abstract_id": "25650633", "label": "results", "text": "Eleven ( @ % ) of @ patients in the supraclavicular group versus @ ( @ % ) of @ in the infraclavicular group had complete hemidiaphragmatic paralysis ( P = @ -LSB- @-tailed -RSB- ; relative risk , @ -LSB- @ % confidence interval , @-@ @ -RSB- ) ; @ % versus @ % had any ( complete or partial ) paralysis ( P = @ ; relative risk , @ -LSB- @ % confidence interval , @-@ @ -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "25650633", "label": "results", "text": "Eight ( @ % ) of @ patients in the supraclavicular group versus @ ( @ % ) of @ in the infraclavicular group reported dyspnea ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25650633", "label": "conclusions", "text": "Ultrasound-guided supraclavicular blockade with @ mL of @ % ropivacaine produced complete hemidiaphragmatic paralysis in approximately one-third of patients .", "sentence_id": 8}
+{"abstract_id": "25650633", "label": "conclusions", "text": "The infraclavicular approach greatly reduced this risk but did not eliminate it .", "sentence_id": 9}
+{"abstract_id": "25650633", "label": "conclusions", "text": "These data may aid in the selection of the approach to brachial plexus blockade , particularly in ambulatory patients and/or those with respiratory comorbidities .", "sentence_id": 10}
+{"abstract_id": "24284442", "label": "background", "text": "Leucine is a key amino acid involved in the regulation of skeletal muscle protein synthesis .", "sentence_id": 0}
+{"abstract_id": "24284442", "label": "objective", "text": "We assessed the effect of the supplementation of a lower-protein mixed macronutrient beverage with varying doses of leucine or a mixture of branched chain amino acids ( BCAAs ) on myofibrillar protein synthesis ( MPS ) at rest and after exercise .", "sentence_id": 1}
+{"abstract_id": "24284442", "label": "methods", "text": "In a parallel group design , @ men ( @ @ y ) completed unilateral knee-extensor resistance exercise before the ingestion of @ g whey protein ( W@ ) ( @ g leucine ) , @ g whey protein ( W@ ) ( @ g leucine ) , @ g whey protein supplemented with leucine to @ g total leucine ( W@ + Low-Leu ) , @ g whey protein supplemented with leucine to @ g total leucine ( W@ + High-Leu ) , or @ g whey protein supplemented with leucine , isoleucine , and valine to @ g total leucine .", "sentence_id": 2}
+{"abstract_id": "24284442", "label": "methods", "text": "A primed continuous infusion of l - -LSB- ring - ( @ ) C@ -RSB- phenylalanine with serial muscle biopsies was used to measure MPS under baseline fasted and postprandial conditions in both a rested ( response to feeding ) and exercised ( response to combined feeding and resistance exercise ) leg .", "sentence_id": 3}
+{"abstract_id": "24284442", "label": "results", "text": "The area under the blood leucine curve was greatest for the W@ + High-Leu group compared with the W@ and W@ + Low-Leu groups ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24284442", "label": "results", "text": "In the postprandial period , rates of MPS were increased above baseline over @-@ @ h in all treatments .", "sentence_id": 5}
+{"abstract_id": "24284442", "label": "results", "text": "Over @-@ @ h , MPS remained increased above baseline after all treatments but was greatest after W@ ( @ % ) and W@ + High-Leu ( @ % ) treatments ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24284442", "label": "conclusions", "text": "A low-protein ( @ g ) mixed macronutrient beverage can be as effective as a high-protein dose ( @ g ) at stimulating increased MPS rates when supplemented with a high ( @ g total leucine ) amount of leucine .", "sentence_id": 7}
+{"abstract_id": "24284442", "label": "conclusions", "text": "These results have important implications for formulations of protein beverages designed to enhance muscle anabolism .", "sentence_id": 8}
+{"abstract_id": "24284442", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT @ .", "sentence_id": 9}
+{"abstract_id": "25869393", "label": "objective", "text": "Prucalopride is effective at alleviating symptoms of chronic constipation in women .", "sentence_id": 0}
+{"abstract_id": "25869393", "label": "objective", "text": "The aim of this study was to assess the efficacy of @ weeks of prucalopride treatment compared with placebo in men with chronic constipation .", "sentence_id": 1}
+{"abstract_id": "25869393", "label": "methods", "text": "This was a multicenter , stratified , randomized , parallel-group , double-blind , placebo-controlled , phase @ study ( ClinicalTrials.gov identifier : NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "25869393", "label": "methods", "text": "The primary end point was the proportion of patients with a mean of three or more spontaneous complete bowel movements ( SCBMs ) per week across the treatment period .", "sentence_id": 3}
+{"abstract_id": "25869393", "label": "methods", "text": "Efficacy end points were assessed using daily electronic diaries , global assessment of the severity of constipation and efficacy of treatment , and Patient Assessment of Constipation-Symptoms ( PAC-SYM ) and Patient Assessment of Constipation-Quality of Life ( PAC-QOL ) questionnaires .", "sentence_id": 4}
+{"abstract_id": "25869393", "label": "results", "text": "In total , @ patients were enrolled in the study .", "sentence_id": 5}
+{"abstract_id": "25869393", "label": "results", "text": "Significantly more patients achieved a mean of three or more SCBMs per week in the prucalopride group ( @ % ) than in the placebo group ( @ % , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25869393", "label": "results", "text": "The proportion of patients rating their constipation treatment as `` quite a bit '' to `` extremely '' effective at the final on-treatment visit was @ and @ % in the prucalopride and placebo groups , respectively .", "sentence_id": 7}
+{"abstract_id": "25869393", "label": "results", "text": "The difference between treatment groups was statistically significant ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25869393", "label": "results", "text": "The proportion of patients with an improvement of at least @ point in PAC-QOL satisfaction subscale score was @ and @ % in the prucalopride and placebo groups , respectively ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25869393", "label": "results", "text": "Prucalopride had a good safety profile and was well tolerated .", "sentence_id": 10}
+{"abstract_id": "25869393", "label": "conclusions", "text": "Prucalopride is effective , has a good safety profile , and is well tolerated for the treatment of men with chronic constipation .", "sentence_id": 11}
+{"abstract_id": "26095435", "label": "background", "text": "People with prediabetes are at increased risk for developing type @ diabetes mellitus .", "sentence_id": 0}
+{"abstract_id": "26095435", "label": "background", "text": "Weight reduction through lifestyle modification can significantly reduce diabetes risk .", "sentence_id": 1}
+{"abstract_id": "26095435", "label": "background", "text": "Yet , weight loss varies among individuals and some people do not achieve clinically meaningful weight loss after treatment .", "sentence_id": 2}
+{"abstract_id": "26095435", "label": "objective", "text": "Our aim was to evaluate the time point and threshold for achieving @ % weight loss after completion of a @-week worksite , lifestyle intervention for diabetes prevention .", "sentence_id": 3}
+{"abstract_id": "26095435", "label": "methods", "text": "Weight change before and after the behavioral intervention among participants randomized to the experimental group was examined .", "sentence_id": 4}
+{"abstract_id": "26095435", "label": "methods", "text": "Individuals with prediabetes aged @ to @ years with a body mass index ( calculated as kg/m ( @ ) ) of @ to @ at Ohio State University were eligible .", "sentence_id": 5}
+{"abstract_id": "26095435", "label": "methods", "text": "The @-week , group-based intervention , adapted from the Diabetes Prevention Program , was delivered to @ participants in the experimental group .", "sentence_id": 6}
+{"abstract_id": "26095435", "label": "methods", "text": "Percent weight loss was assessed weekly during the intervention and at @ - and @-month follow-up .", "sentence_id": 7}
+{"abstract_id": "26095435", "label": "methods", "text": "Linear regression modeled the relationship between percent weight loss during month @ of the intervention and percent weight loss at @ and @ months .", "sentence_id": 8}
+{"abstract_id": "26095435", "label": "methods", "text": "Logistic regression modeled failure to lose @ % weight loss at @ and @ months using weekly weight change during the first month of intervention .", "sentence_id": 9}
+{"abstract_id": "26095435", "label": "results", "text": "Percent weight loss at intervention week @ was significantly associated with percent weight loss at @ and @ months ( all P < @ ) .", "sentence_id": 10}
+{"abstract_id": "26095435", "label": "results", "text": "Only @ % and @ % of participants who failed to achieve a @ % weight-loss threshold during month @ achieved @ % weight loss at months @ and @ , respectively .", "sentence_id": 11}
+{"abstract_id": "26095435", "label": "conclusions", "text": "The first month of lifestyle treatment is a critical period for helping participants achieve weight loss .", "sentence_id": 12}
+{"abstract_id": "26095435", "label": "conclusions", "text": "Otherwise , individuals who fail to achieve at least @ % weight loss may benefit from more intensive rescue efforts or stepped-care interventions .", "sentence_id": 13}
+{"abstract_id": "25011946", "label": "objective", "text": "Mealtime insulin is commonly added to manage hyperglycemia in type @ diabetes when basal insulin is insufficient .", "sentence_id": 0}
+{"abstract_id": "25011946", "label": "objective", "text": "However , this complex regimen is associated with weight gain and hypoglycemia .", "sentence_id": 1}
+{"abstract_id": "25011946", "label": "objective", "text": "This study compared the efficacy and safety of exenatide twice daily or mealtime insulin lispro in patients inadequately controlled by insulin glargine and metformin despite up-titration .", "sentence_id": 2}
+{"abstract_id": "25011946", "label": "methods", "text": "In this @-week , open-label , multicenter , randomized , noninferiority trial with @ weeks prior insulin optimization , @ patients with insufficient postoptimization glycated hemoglobin A@c ( HbA@c ) were randomized to exenatide ( @-@ g/day ) or thrice-daily mealtime lispro titrated to premeal glucose of @-@ @ mmol/L , both added to insulin glargine ( mean @ units/day at randomization ) and metformin ( mean @,@ mg/day ) .", "sentence_id": 3}
+{"abstract_id": "25011946", "label": "results", "text": "Randomization HbA@c and fasting glucose ( FG ) were @ % ( @ mmol/mol ) and @ mmol/L for exenatide and @ % ( @ mmol/mol ) and @ mmol/L for lispro .", "sentence_id": 4}
+{"abstract_id": "25011946", "label": "results", "text": "At @ weeks postrandomization , mean HbA@c changes were noninferior for exenatide compared with lispro ( -@ and -@ % , respectively ) ; treatment differences were -@ ( @ % CI -@ , @ ) in per-protocol ( n = @ ) and -@ ( @ % CI -@ , @ ) in intent-to-treat ( n = @ ) populations .", "sentence_id": 5}
+{"abstract_id": "25011946", "label": "results", "text": "FG was lower with exenatide than lispro ( @ vs. @ mmol/L ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25011946", "label": "results", "text": "Weight decreased with exenatide and increased with lispro ( -@ vs. +@ kg ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25011946", "label": "results", "text": "More patients reported treatment satisfaction and better quality of life with exenatide than lispro , although a larger proportion of patients with exenatide experienced treatment-emergent adverse events .", "sentence_id": 8}
+{"abstract_id": "25011946", "label": "results", "text": "Exenatide resulted in fewer nonnocturnal hypoglycemic episodes but more gastrointestinal adverse events than lispro .", "sentence_id": 9}
+{"abstract_id": "25011946", "label": "conclusions", "text": "Adding exenatide to titrated glargine with metformin resulted in similar glycemic control as adding lispro and was well tolerated .", "sentence_id": 10}
+{"abstract_id": "25011946", "label": "conclusions", "text": "These findings support exenatide as a noninsulin addition for patients failing basal insulin .", "sentence_id": 11}
+{"abstract_id": "25078901", "label": "objective", "text": "We evaluated the effect of the MD-Logic system on overnight glycemic control at patients ' homes .", "sentence_id": 0}
+{"abstract_id": "25078901", "label": "methods", "text": "Twenty-four patients ( aged @-@ years ; average A@c @ @ % , @ @ mmol/mol ) were randomly assigned to participate in two overnight crossover periods , each including @ weeks of consecutive nights : one under closed loop and the second under sensor-augmented pump ( SAP ) therapy at patients ' homes in real-life conditions .", "sentence_id": 1}
+{"abstract_id": "25078901", "label": "methods", "text": "The primary end point was time spent with sensor glucose levels below @ mg/dL ( @ mmol/L ) overnight .", "sentence_id": 2}
+{"abstract_id": "25078901", "label": "results", "text": "Closed-loop nights significantly reduced time spent in hypoglycemia ( P = @ ) and increased the percentage of time spent in the target range of @-@ mg/dL ( P = @ ) compared with nights when the SAP therapy was used .", "sentence_id": 3}
+{"abstract_id": "25078901", "label": "results", "text": "The time spent in substantial hyperglycemia above @ mg/dL was reduced by a median of @ % ( interquartile range -LSB- IQR -RSB- @ , @ % ; P = @ ) under closed-loop control compared with SAP therapy .", "sentence_id": 4}
+{"abstract_id": "25078901", "label": "results", "text": "Overnight total insulin doses were lower in the closed-loop nights compared with the SAP nights ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25078901", "label": "results", "text": "The average daytime glucose levels after closed-loop operation were reduced by a median of @ mg/dL ( IQR -@ , @ ; P = @ ) while lower total insulin doses were used ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25078901", "label": "results", "text": "No severe adverse events occurred during closed-loop control ; there was a single event of severe hypoglycemia during a control night .", "sentence_id": 7}
+{"abstract_id": "25078901", "label": "conclusions", "text": "The long-term home use of automated overnight insulin delivery by the MD-Logic system was found to be a feasible , safe , and an effective tool to reduce nocturnal hypoglycemia and improve overnight glycemic control in subjects with type @ diabetes .", "sentence_id": 8}
+{"abstract_id": "25405577", "label": "objective", "text": "This study aimed to describe pretreatment patient characteristics and baseline quality-of-life scores as they relate to the development of grade @ or @ toxicity in patients receiving chemotherapy for advanced/recurrent cervical cancer .", "sentence_id": 0}
+{"abstract_id": "25405577", "label": "methods", "text": "The study sample was drawn from Gynecologic Oncology Group protocols @ and @ .", "sentence_id": 1}
+{"abstract_id": "25405577", "label": "methods", "text": "Grade @ or @ toxicities were considered in @ specified categories as follows : peripheral neuropathy , fatigue , hematological , and gastrointestinal ( GI ) .", "sentence_id": 2}
+{"abstract_id": "25405577", "label": "methods", "text": "The data variables explored included age , stage , pretreatment radiation , performance status ( PS ) at treatment initiation , and baseline Functional Assessment of Cancer Therapy-Cervix ( FACT-Cx ) score .", "sentence_id": 3}
+{"abstract_id": "25405577", "label": "methods", "text": "A logistic regression model was developed with various adverse events as binary ( @/@ ) outcomes .", "sentence_id": 4}
+{"abstract_id": "25405577", "label": "results", "text": "Six hundred seventy-three patient-reported questionnaires were used in the analyses .", "sentence_id": 5}
+{"abstract_id": "25405577", "label": "results", "text": "At baseline , pain was the most severe patient-reported symptom .", "sentence_id": 6}
+{"abstract_id": "25405577", "label": "results", "text": "Baseline line-item patient concerns did demonstrate specific correlations with the development of individual toxicities .", "sentence_id": 7}
+{"abstract_id": "25405577", "label": "results", "text": "In @ patients who were enrolled on Gynecologic Oncology Group @ ( fatigue not measured on @ ) , a worse PS predicted the development of grade @ or @ fatigue ( odds ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25405577", "label": "results", "text": "Exposure to previous radiation , treatment regimen , and a worse FACT-Cx score were associated with the reporting of both grade @ or @ leukopenia ( P < @ ) and anemia ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25405577", "label": "results", "text": "Performance status and treatment regimen ( P < @ ) were associated with the development of grade @ or @ thrombocytopenia .", "sentence_id": 10}
+{"abstract_id": "25405577", "label": "results", "text": "Age and treatment regimen ( P < @ ) were associated with the development of grade @ or @ neutropenia .", "sentence_id": 11}
+{"abstract_id": "25405577", "label": "results", "text": "The FACT-Cx score ( P = @ ) predicted grade @ or @ GI toxicity .", "sentence_id": 12}
+{"abstract_id": "25405577", "label": "conclusions", "text": "The development of fatigue , hematological , and GI toxicity might be predictable based on factors other than treatment assignment such as age , PS , and patient-reported quality-of-life measurement .", "sentence_id": 13}
+{"abstract_id": "24708645", "label": "background", "text": "The ongoing scale-up of antiretroviral therapy ( ART ) in sub-Saharan Africa has prompted the interest in surveillance of transmitted and acquired HIV drug resistance .", "sentence_id": 0}
+{"abstract_id": "24708645", "label": "background", "text": "Resistance data on virological failure and mutations in HIV infected populations initiating treatment in sub-Saharan Africa is sparse .", "sentence_id": 1}
+{"abstract_id": "24708645", "label": "methods", "text": "HIV viral load ( VL ) and resistance mutations pre-ART and after @ months were determined in a prospective cohort study of ART-nave HIV patients initiating first-line therapy in Jimma , Ethiopia .", "sentence_id": 2}
+{"abstract_id": "24708645", "label": "methods", "text": "VL measurements were done at baseline and after @ and @ months .", "sentence_id": 3}
+{"abstract_id": "24708645", "label": "methods", "text": "Genotypic HIV drug resistance ( HIVDR ) was performed on patients exhibiting virological failure ( > @ copies/mL at @ months ) or slow virological response ( > @ copies/mL at @ months and < @ copies/mL at @ months ) .", "sentence_id": 4}
+{"abstract_id": "24708645", "label": "results", "text": "Two hundred sixty five patients had VL data available at baseline and at @ months .", "sentence_id": 5}
+{"abstract_id": "24708645", "label": "results", "text": "Virological failure was observed among @ ( @ % ) participants out of @ patients .", "sentence_id": 6}
+{"abstract_id": "24708645", "label": "results", "text": "Twelve samples were genotyped and six had HIV drug resistance ( HIVDR ) mutations at baseline .", "sentence_id": 7}
+{"abstract_id": "24708645", "label": "results", "text": "Among virological failures , @/@ ( @ % ) harbored one or more HIVDR mutations at @ months .", "sentence_id": 8}
+{"abstract_id": "24708645", "label": "results", "text": "The most frequent mutations were K@N and M@VI .", "sentence_id": 9}
+{"abstract_id": "24708645", "label": "conclusions", "text": "Our data confirm that the currently recommended first-line ART regimen is efficient in the vast majority of individuals initiating therapy in Jimma , Ethiopia eight years after the introduction of ART .", "sentence_id": 10}
+{"abstract_id": "24708645", "label": "conclusions", "text": "However , the documented occurrence of transmitted resistance and accumulation of acquired HIVDR mutations among failing patients justify increased vigilance by improving the availability and systematic use of VL testing to monitor ART response , and underlines the need for rapid , inexpensive tests to identify the most common drug resistance mutations .", "sentence_id": 11}
+{"abstract_id": "24419019", "label": "background", "text": "Mirror therapy ( MT ) and electromyography-triggered neuromuscular stimulation ( ETMS ) are both effective treatments for impaired upper limbs following stroke .", "sentence_id": 0}
+{"abstract_id": "24419019", "label": "background", "text": "A combination of these two treatments ( ETMS-MT ) may result in greater gain than either treatment alone .", "sentence_id": 1}
+{"abstract_id": "24419019", "label": "objective", "text": "The feasibility and possible effects of ETMS-MT upon upper extremity function were investigated in stroke patients .", "sentence_id": 2}
+{"abstract_id": "24419019", "label": "methods", "text": "Thirteen post-acute stroke patients were randomly assigned to an immediate ETMS-MT group or a delayed ETMS-MT group and then underwent an @-week training program .", "sentence_id": 3}
+{"abstract_id": "24419019", "label": "methods", "text": "The immediate ETMS-MT group received ETMS-MT in addition to physical and occupational therapy ( PT+OT ) for @ weeks .", "sentence_id": 4}
+{"abstract_id": "24419019", "label": "methods", "text": "They then received only PT+OT for the next @ weeks .", "sentence_id": 5}
+{"abstract_id": "24419019", "label": "methods", "text": "In the delayed ETMS-MT group , interventions were provided in the reverse order .", "sentence_id": 6}
+{"abstract_id": "24419019", "label": "methods", "text": "The main outcome measure was the Fugl-Meyer Assessment ( FMA ) .", "sentence_id": 7}
+{"abstract_id": "24419019", "label": "results", "text": "The immediate ETMS-MT group showed significantly greater gain in FMA in the first @ weeks .", "sentence_id": 8}
+{"abstract_id": "24419019", "label": "results", "text": "The delayed ETMS-MT group showed significantly greater gain in active range of motion during the latter @ weeks .", "sentence_id": 9}
+{"abstract_id": "24419019", "label": "results", "text": "No adverse effects were reported following ETMS-MT .", "sentence_id": 10}
+{"abstract_id": "24419019", "label": "conclusions", "text": "ETMS-MT might be as effective as independent MT or ETMS without causing any side effects .", "sentence_id": 11}
+{"abstract_id": "24419019", "label": "conclusions", "text": "Future research should focus upon the direct comparisons between independent and combined interventions .", "sentence_id": 12}
+{"abstract_id": "24329481", "label": "background", "text": "Gold-standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue .", "sentence_id": 0}
+{"abstract_id": "24329481", "label": "background", "text": "However , this process is invasive with recognized side-effects .", "sentence_id": 1}
+{"abstract_id": "24329481", "label": "background", "text": "Optical coherence tomography ( OCT ) is a noninvasive technique generating high-resolution real-time images of cutaneous architecture .", "sentence_id": 2}
+{"abstract_id": "24329481", "label": "objective", "text": "To compare OCT with histological assessment of in vivo acute wound healing and ascertain the level of agreement between modalities for measurement of defined cutaneous structures .", "sentence_id": 3}
+{"abstract_id": "24329481", "label": "methods", "text": "Punch biopsies ( @mm ) were harvested from @ healthy volunteers .", "sentence_id": 4}
+{"abstract_id": "24329481", "label": "methods", "text": "Wounds healed by secondary intention until they were re-excised @ , @ , @ or @days later depending on random group allocation .", "sentence_id": 5}
+{"abstract_id": "24329481", "label": "methods", "text": "Wounds were assessed weekly for @weeks using OCT and compared with histological findings derived from time-matched biopsies .", "sentence_id": 6}
+{"abstract_id": "24329481", "label": "methods", "text": "Dimensions of four cutaneous structures were measured using both modalities and the level of agreement was established by Bland-Altman analysis .", "sentence_id": 7}
+{"abstract_id": "24329481", "label": "methods", "text": "The mean greyscale value ( MGV ) of the upper reticular dermis was derived from OCT images at all time points .", "sentence_id": 8}
+{"abstract_id": "24329481", "label": "results", "text": "Both techniques showed anatomical congruity in normal and wounded skin with correlating architectural changes associated with inflammatory , proliferative and remodelling wound healing phases .", "sentence_id": 9}
+{"abstract_id": "24329481", "label": "results", "text": "MGV was significantly increased @weeks after wounding ( P = @ ) and may represent a novel measure of wound fibrosis .", "sentence_id": 10}
+{"abstract_id": "24329481", "label": "results", "text": "Despite good association of histomorphometric values with low but consistent bias ( range -@ to @m ) , Bland-Altman plots demonstrated poor agreement between OCT and histology .", "sentence_id": 11}
+{"abstract_id": "24329481", "label": "conclusions", "text": "Optical coherence tomography enabled accurate assessment of healing tissue comparable with histological analysis of biopsy specimens .", "sentence_id": 12}
+{"abstract_id": "24329481", "label": "conclusions", "text": "This noninvasive tool is highly suited to wound assessment and may represent a diagnostic alternative to punch biopsies .", "sentence_id": 13}
+{"abstract_id": "25197812", "label": "objective", "text": "Obstructive sleep apnea ( OSA ) is commoner in patients with fluid-retaining states than in those without fluid retention , in men than in women , and worsens with aging .", "sentence_id": 0}
+{"abstract_id": "25197812", "label": "objective", "text": "In men , OSA severity is related to the amount of fluid shifting out of the legs overnight , but a cause-effect relationship is not established .", "sentence_id": 1}
+{"abstract_id": "25197812", "label": "objective", "text": "Our objective was to test the hypothesis that mimicking fluid overload during sleep would increase severity of OSA more in older ( @ years ) than in younger men ( < @ years ) .", "sentence_id": 2}
+{"abstract_id": "25197812", "label": "methods", "text": "Randomized , single-blind , double crossover study .", "sentence_id": 3}
+{"abstract_id": "25197812", "label": "methods", "text": "Research sleep laboratory .", "sentence_id": 4}
+{"abstract_id": "25197812", "label": "methods", "text": "Seven older and @ younger men with non-severe or no sleep apnea , matched for body mass index .", "sentence_id": 5}
+{"abstract_id": "25197812", "label": "methods", "text": "During the control arm , normal saline was infused to keep the vein open .", "sentence_id": 6}
+{"abstract_id": "25197812", "label": "methods", "text": "During intervention , subjects received an intravenous bolus of normal saline ( @ mL/kg body weight ) after sleep onset while they were wearing compression stockings to prevent fluid accumulation in the legs .", "sentence_id": 7}
+{"abstract_id": "25197812", "label": "results", "text": "Compared to younger men , infusion of similar amounts of saline in older men caused a greater increase in neck circumference ( P < @ ) and in the AHI ( @ @ vs. @ @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25197812", "label": "conclusions", "text": "Older men are more susceptible to the adverse effects of intravenous fluid loading on obstructive sleep apnea severity than younger men .", "sentence_id": 9}
+{"abstract_id": "25197812", "label": "conclusions", "text": "This may be due to age-related differences in the amount of fluid accumulating in the neck or upper airway collapsibility in response to intravenous fluid loading .", "sentence_id": 10}
+{"abstract_id": "25197812", "label": "conclusions", "text": "These possibilities remain to be tested in future studies .", "sentence_id": 11}
+{"abstract_id": "24662128", "label": "objective", "text": "Biopsy confirmed that cervical intraepithelial neoplasia ( CIN ) may naturally regress or progress .", "sentence_id": 0}
+{"abstract_id": "24662128", "label": "objective", "text": "Currently , the risk assessment for CIN progression to cervical cancer is still not satisfactory in clinical practice .", "sentence_id": 1}
+{"abstract_id": "24662128", "label": "objective", "text": "We investigated copy number and protein expression of TP@ and MYC and explored the possibility to use them as progression biomarkers .", "sentence_id": 2}
+{"abstract_id": "24662128", "label": "methods", "text": "Copy numbers of TP@ and MYC , as well as human papilloma virus ( HPV ) integration status , were determined by fluorescence in situ hybridization in @ patients with CIN and @ patients with cervical cancer .", "sentence_id": 3}
+{"abstract_id": "24662128", "label": "methods", "text": "Corresponding protein expressions were analyzed by immunohistochemistry .", "sentence_id": 4}
+{"abstract_id": "24662128", "label": "methods", "text": "Receiver operating characteristic curves were used to measure the diagnostic test performance for the detection of cervical cancer from CIN .", "sentence_id": 5}
+{"abstract_id": "24662128", "label": "methods", "text": "Sensitivity and specificity values of biomarkers were calculated .", "sentence_id": 6}
+{"abstract_id": "24662128", "label": "results", "text": "The average copy number and expression of TP@ and MYC , as well as the HPV integration rate , increased in the progression of CIN to cervical cancer .", "sentence_id": 7}
+{"abstract_id": "24662128", "label": "results", "text": "Receiver operating characteristic analysis for detection of cervical cancer resulted in area under the curve ( AUC ) values of TP@ copy number ( AUC , @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) , MYC copy number ( AUC , @ ; @ % CI , @-@ @ ) , TP@ expression ( AUC , @ ; @ % CI , @-@ @ ) , and HPV-@ integration ( AUC , @ ; @ % CI , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24662128", "label": "results", "text": "MYC expression was not able to statistically distinguish cancer from CIN ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24662128", "label": "results", "text": "The combinations increased the specificity slightly but not sensitivity .", "sentence_id": 10}
+{"abstract_id": "24662128", "label": "results", "text": "Among them , TP@ amplification showed the best diagnostic performance .", "sentence_id": 11}
+{"abstract_id": "24662128", "label": "conclusions", "text": "Amplification and overexpression of TP@ and MYC , and HPV integration rate , are associated with the transition of CIN to cervical cancer .", "sentence_id": 12}
+{"abstract_id": "24662128", "label": "conclusions", "text": "Future studies on these biomarkers will help to assess the risk of CIN progression .", "sentence_id": 13}
+{"abstract_id": "25262259", "label": "background", "text": "Discontinuations and/or interruptions in aspirin therapy for secondary cardioprotection due to upper gastrointestinal ( UGI ) complications or symptoms have been shown to increase the risk for subsequent cardiovascular events .", "sentence_id": 0}
+{"abstract_id": "25262259", "label": "background", "text": "PA@ is a coordinated-delivery , combination tablet consisting of enteric-coated aspirin ( EC-ASA ) @ mg and immediate-release ( IR ) omeprazole @ mg .", "sentence_id": 1}
+{"abstract_id": "25262259", "label": "methods", "text": "Two identically-designed , @-month , randomized , double-blind trials evaluated PA@ vs. EC-ASA @ mg in a secondary cardiovascular disease prevention population taking aspirin @ mg daily for @ months and at risk for ASA-associated gastric ulcers ( GUs ) .", "sentence_id": 2}
+{"abstract_id": "25262259", "label": "methods", "text": "The combined study population was @ subjects ( @ randomized to PA@ , @ to EC-ASA @ mg ) .", "sentence_id": 3}
+{"abstract_id": "25262259", "label": "methods", "text": "The primary endpoint was the occurrence of endoscopically-determined gastric ulceration over @ months .", "sentence_id": 4}
+{"abstract_id": "25262259", "label": "methods", "text": "Safety outcomes included the rates of major adverse cardiovascular events ( MACE ) and UGI symptoms .", "sentence_id": 5}
+{"abstract_id": "25262259", "label": "results", "text": "Significantly fewer PA@-treated subjects ( @ % ) developed endoscopic GUs vs. EC-ASA @ mg-treated subjects ( @ % ) ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25262259", "label": "results", "text": "Overall occurrence of MACE was low ( @ % ) , with no significant differences between treatments in types or incidence of MACE .", "sentence_id": 7}
+{"abstract_id": "25262259", "label": "results", "text": "PA@-treated subjects had significantly fewer UGI symptoms ( P < @ ) and significantly fewer discontinuations due to pre-specified UGI adverse events ( @ % vs. @ % , respectively ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25262259", "label": "conclusions", "text": "PA@ reduced the incidence of endoscopic GUs compared to EC-ASA @ mg , but with a similar cardiovascular event profile .", "sentence_id": 9}
+{"abstract_id": "25262259", "label": "conclusions", "text": "Due to fewer UGI symptoms , continuation on aspirin therapy was greater in the PA@ treatment arm .", "sentence_id": 10}
+{"abstract_id": "24410783", "label": "background", "text": "Anaphylaxis is a life-threatening emergency .", "sentence_id": 0}
+{"abstract_id": "24410783", "label": "background", "text": "If promptly administered , adrenaline is potentially life-saving .", "sentence_id": 1}
+{"abstract_id": "24410783", "label": "background", "text": "Many food-allergic-children/carers are unsure when to use their adrenaline autoinjectors , contributing to a low quality of life and worse outcomes in the setting of an acute allergic reaction .", "sentence_id": 2}
+{"abstract_id": "24410783", "label": "objective", "text": "The aim of this study was to assess the effectiveness of @-hour telephone access to specialist clinical advice on disease-specific quality of life .", "sentence_id": 3}
+{"abstract_id": "24410783", "label": "methods", "text": "A pragmatic two-arm , parallel-group randomized control trial was conducted .", "sentence_id": 4}
+{"abstract_id": "24410783", "label": "methods", "text": "Children/carers ( < @years ) with food allergy , trained in adrenaline auto-injector use , were recruited from a hospital-based paediatric allergy clinic .", "sentence_id": 5}
+{"abstract_id": "24410783", "label": "methods", "text": "Baseline disease-specific quality of life was ascertained using the validated Food-Allergy-Related Quality-of-Life Questionnaire ( FAQLQ ) , either Parent Form , Child Form or Teenager Form depending on child 's age .", "sentence_id": 6}
+{"abstract_id": "24410783", "label": "methods", "text": "Participants were then centrally randomized for a @-month period to @-hour telephone specialist support line or to usual care .", "sentence_id": 7}
+{"abstract_id": "24410783", "label": "methods", "text": "The primary outcome measure was a change in FAQL scores , at one and @months postrandomization , compared with baseline .", "sentence_id": 8}
+{"abstract_id": "24410783", "label": "methods", "text": "The minimum clinically important difference ( MCID ) in score is @ .", "sentence_id": 9}
+{"abstract_id": "24410783", "label": "results", "text": "Fifty two children/carers were recruited .", "sentence_id": 10}
+{"abstract_id": "24410783", "label": "results", "text": "FAQL scores remained static in the control group across the three time points .", "sentence_id": 11}
+{"abstract_id": "24410783", "label": "results", "text": "Scores gradually improved in the intervention group , with a significant difference seen at @months ( T@-T@ Mean difference = -@ , ( CI @-@ @ ) P < @ -RSB- Follow-up questionnaires , @months after the intervention was removed , T@ , showed sustained significant difference between the groups ( control M = @ ; intervention M = @ -LSB- t = -@ , P < @ -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "24410783", "label": "conclusions", "text": "The @-hour helpline improved food-allergy-specific quality of life in children .", "sentence_id": 13}
+{"abstract_id": "24410783", "label": "conclusions", "text": "Six-month intervention support resulted in sustained benefits for at least a further @months .", "sentence_id": 14}
+{"abstract_id": "25146509", "label": "objective", "text": "To evaluate the effects of prone position ventilation combined with recruitment maneuvers ( RM ) on clinical outcomes in patients with severe acute respiratory distress syndrome ( ARDS ) .", "sentence_id": 0}
+{"abstract_id": "25146509", "label": "methods", "text": "In this prospective , randomized , controlled trial , we randomly assigned @ sequential patients with severe ARDS to the intervention group ( which undergo prone-positioning with RM sessions of at least @ hours ) or to the control group ( which be left in the supine position ) .", "sentence_id": 1}
+{"abstract_id": "25146509", "label": "results", "text": "From July @ to July @ , @ severe ARDS patients sequentially admitted to the critical department of Peking Union Medical College Hospital were enrolled in the study with @ patients assigned to the control group and @ patients to the intervention group .", "sentence_id": 2}
+{"abstract_id": "25146509", "label": "results", "text": "No significant difference was found between the two groups in the demographics including the median patient age , sex ratio , initial Acute Physiology and Chronic Health Evaluation II scores , initial pulmonary function and the sources of ARDS .", "sentence_id": 3}
+{"abstract_id": "25146509", "label": "results", "text": "The oxygenation index recorded in the supine position was significantly higher in the intervention group than in the control group since day @ , whereas the positive end-expiratory pressure and fraction of inspired O@ were significantly lower in the intervention group .", "sentence_id": 4}
+{"abstract_id": "25146509", "label": "results", "text": "The plateau pressure and static compliance of the respiratory system were similar in the two groups .", "sentence_id": 5}
+{"abstract_id": "25146509", "label": "results", "text": "The intervention group had shorter length of ICU stay , fewer ventilation days and decreased @-day mortality than the control group .", "sentence_id": 6}
+{"abstract_id": "25146509", "label": "results", "text": "The tracheotomy ratio and the time to successful extubation were similar in the two groups .", "sentence_id": 7}
+{"abstract_id": "25146509", "label": "results", "text": "No significant difference between the two groups was shown in the incidence of complications , except for the grade @ pressure sore , which was higher in the intervention group .", "sentence_id": 8}
+{"abstract_id": "25146509", "label": "conclusions", "text": "In patients with severe ARDS , application of prolonged prone-positioning with RM sessions significantly improves the clinical outcomes .", "sentence_id": 9}
+{"abstract_id": "24548289", "label": "background", "text": "Diets rich in fermentable residues increase intestinal gas production .", "sentence_id": 0}
+{"abstract_id": "24548289", "label": "background", "text": "Our aim was to demonstrate the potential effects of diet on gas-related symptoms .", "sentence_id": 1}
+{"abstract_id": "24548289", "label": "methods", "text": "The effect of a low-flatulogenic test diet ( restricted to foodstuffs low in fermentable residues ; n = @ ) was compared to that of a balanced control diet ( Mediterranean type ; n = @ ) in @ patients complaining of flatulence and other abdominal symptoms using a randomized parallel design .", "sentence_id": 2}
+{"abstract_id": "24548289", "label": "methods", "text": "The following outcomes were measured daily : number of anal gas evacuations by an event marker , severity of gas-related symptoms by @-@ scales , and sensation of digestive comfort by a -@ ( unpleasant ) to +@ ( pleasant ) scale .", "sentence_id": 3}
+{"abstract_id": "24548289", "label": "methods", "text": "Measurements were taken pretreatment for @days on their habitual diet and for @days during the treatment phase .", "sentence_id": 4}
+{"abstract_id": "24548289", "label": "results", "text": "No pretreatment differences were detected between patients allocated to the control or test diets .", "sentence_id": 5}
+{"abstract_id": "24548289", "label": "results", "text": "The test diet significantly reduced the number of gas evacuations ( by @ % ; p = @ vs basal diet ) whereas the control diet had a lesser effect ( reduction by @ % ; p = @ vs basal diet ; p = @ vs test diet ) .", "sentence_id": 6}
+{"abstract_id": "24548289", "label": "results", "text": "Compared to the control diet , the test diet significantly reduced flatulence ( by @ % vs @ % , respectively ; p = @ ) , abdominal distension ( by @ % vs @ % , respectively ; p = @ ) , and enhanced digestive well-being ( by @ % vs @ % , respectively ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24548289", "label": "conclusions", "text": "In patients with gas-related symptoms , a low-flatulogenic diet produces immediate beneficial effects with digestive , cognitive , and emotive dimensions .", "sentence_id": 8}
+{"abstract_id": "24548289", "label": "conclusions", "text": "The number of gas evacuations is an objective biological marker of response to dietary treatment .", "sentence_id": 9}
+{"abstract_id": "25457355", "label": "objective", "text": "To examine the efficacy of an integrative yoga programme as adjuvant treatment of essential arterial hypertension .", "sentence_id": 0}
+{"abstract_id": "25457355", "label": "methods", "text": "An Integrative yoga programme was conducted during three months in @ sessions with a group of ten essential arterial hypertension patients at a public health centre .", "sentence_id": 1}
+{"abstract_id": "25457355", "label": "methods", "text": "The same number of patients acted as the control group without treatment .", "sentence_id": 2}
+{"abstract_id": "25457355", "label": "methods", "text": "The patients were randomly selected and assigned to the groups .", "sentence_id": 3}
+{"abstract_id": "25457355", "label": "methods", "text": "All patients filled in the Positive and Negative Affect Schedule ( PANAS ) , the Hospital Anxiety and Depression Scale ( HADS ) and the Smith Relaxation States Inventory @ ( SRSI@ ) before and after the treatment .", "sentence_id": 4}
+{"abstract_id": "25457355", "label": "results", "text": "A statistically significant reduction of systolic and diastolic blood pressure , negative affect , symptoms of anxiety and degree of stress could be observed in the study group .", "sentence_id": 5}
+{"abstract_id": "25457355", "label": "conclusions", "text": "These positive and promising results confirm the effectiveness of these techniques in the treatment of essential arterial hypertension and suggest possible further investigations .", "sentence_id": 6}
+{"abstract_id": "25795645", "label": "objective", "text": "To test if TIA/stroke electronic decision support in primary care improves management .", "sentence_id": 0}
+{"abstract_id": "25795645", "label": "methods", "text": "Multicenter , single-blind , parallel-group , cluster randomized , controlled trial comparing TIA/stroke electronic decision support guided management with usual care .", "sentence_id": 1}
+{"abstract_id": "25795645", "label": "methods", "text": "Main outcomes were guideline adherence and @-day stroke risk .", "sentence_id": 2}
+{"abstract_id": "25795645", "label": "methods", "text": "Secondary outcomes were cerebrovascular/vascular/death / adverse events , cost , and user feedback .", "sentence_id": 3}
+{"abstract_id": "25795645", "label": "methods", "text": "Main analysis was logistic regression with a normal random effect for clusters using a generalized linear mixed model .", "sentence_id": 4}
+{"abstract_id": "25795645", "label": "results", "text": "Twenty-nine clinics were randomized to intervention , @ to control , recruiting @ and @ eligible patients .", "sentence_id": 5}
+{"abstract_id": "25795645", "label": "results", "text": "More intervention patients received guideline-adherent care ( @/@ ; @ % ) than control patients ( @/@ ; @ % ) ( adjusted odds ratio -LSB- OR -RSB- @ ; @ % confidence interval -LSB- CI -RSB- @-@ @ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25795645", "label": "results", "text": "Ninety-day stroke occurred in @/@ ( @ % ) intervention and @/@ ( @ % ) control patients ( OR @ ; @ % CI @-@ @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25795645", "label": "results", "text": "Ninety-day TIA or stroke occurrence was lower in the intervention group , @/@ ( @ % ) compared to @/@ ( @ % ) control ( adjusted OR @ ; @ % CI @-@ @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25795645", "label": "results", "text": "Fewer vascular events/deaths occurred in intervention , @/@ ( @ % ) , than in control patients , @/@ ( @ % ) ( adjusted OR @ ; @ % CI @-@ @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25795645", "label": "results", "text": "Treatment cost ratio of @ ( @ % CI @-@ @ ; p = @ ) favored the intervention without increased adverse events .", "sentence_id": 10}
+{"abstract_id": "25795645", "label": "results", "text": "Clinician feedback was positive .", "sentence_id": 11}
+{"abstract_id": "25795645", "label": "conclusions", "text": "Primary care use of the TIA/stroke electronic decision support tool improves guideline adherence , safely reduces treatment cost , achieves positive user feedback , and may reduce cerebrovascular and vascular event risk following TIA/stroke .", "sentence_id": 12}
+{"abstract_id": "25795645", "label": "methods", "text": "This study provides Class II evidence that a primary care electronic decision support tool improves guideline adherence and might reduce @-day stroke risk .", "sentence_id": 13}
+{"abstract_id": "25190522", "label": "background", "text": "Nicotine is a known analgesic .", "sentence_id": 0}
+{"abstract_id": "25190522", "label": "background", "text": "Our primary aim was to test the hypothesis that intranasal nicotine administered intraoperatively reduces the need for postoperative opioids .", "sentence_id": 1}
+{"abstract_id": "25190522", "label": "background", "text": "The secondary outcomes included evaluation of both postoperative pain and nausea and vomiting ( PONV ) .", "sentence_id": 2}
+{"abstract_id": "25190522", "label": "methods", "text": "Nonsmoking female patients undergoing laparoscopic bariatric operations were randomized to receive either @ mg intranasal nicotine ( N = @ ) or placebo spray ( N = @ ) at the conclusion of surgery .", "sentence_id": 3}
+{"abstract_id": "25190522", "label": "methods", "text": "Postoperative opioid use converted to intravenous morphine equivalents ( iv MEQ ) and PONV rates were recorded during both the recovery room postanesthesia care unit ( PACU ) stay and the first @ postoperative hours .", "sentence_id": 4}
+{"abstract_id": "25190522", "label": "methods", "text": "All patients received multimodal antiemetic prophylaxis .", "sentence_id": 5}
+{"abstract_id": "25190522", "label": "results", "text": "Total iv MEQ were not significantly reduced during the PACU stay in patients receiving nicotine ( median -LSB- interquartile range ( IQR ) -RSB- , @ -LSB- @ , @ -RSB- mg for nicotine vs. @ -LSB- @ , @ -RSB- mg for placebo , one-tailed P = @ ) or for the first @ h following PACU discharge ( @ -LSB- @ , @ -RSB- mg for nicotine vs. @ -LSB- @ , @ -RSB- mg for placebo , one-tailed P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25190522", "label": "results", "text": "For the combined period ( PACU + @-h post-PACU discharge ) , iv MEQ were @ -LSB- @ , @ -RSB- mg for nicotine and @ -LSB- @ , @ -RSB- mg for placebo , one-tailed P = @ .", "sentence_id": 7}
+{"abstract_id": "25190522", "label": "results", "text": "Compared to placebo , a higher percentage of patients administered nicotine received antiemetics in the PACU ( @ vs. @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25190522", "label": "conclusions", "text": "Intraoperative intranasal nicotine did not exhibit opioid-sparing effect in nonsmoking bariatric female patients .", "sentence_id": 9}
+{"abstract_id": "25190522", "label": "conclusions", "text": "Despite antiemetic prophylaxis , the use of nicotine was associated with the higher frequency of the use of rescue antiemetics in PACU .", "sentence_id": 10}
+{"abstract_id": "25335329", "label": "objective", "text": "To study the effect of Shugan Jiangu Recipe ( SJR ) on bone mineral density ( BMD ) and serum bone metabolic biochemical markers in postmenopausal breast cancer patients with osteopenia .", "sentence_id": 0}
+{"abstract_id": "25335329", "label": "methods", "text": "Totally @ patients of postmenopausal women with breast cancer , who received aromatase inhibitors ( AIs ) , were assigned to the treatment group ( @ cases ) and the control group ( @ cases ) by using random digit table .", "sentence_id": 1}
+{"abstract_id": "25335329", "label": "methods", "text": "All patients took Caltrate D Tablet ( containing Ca @ mg and Vit D@ @ IU ) , one tablet daily .", "sentence_id": 2}
+{"abstract_id": "25335329", "label": "methods", "text": "Patients in the treatment group took SJR , @ g each time , twice daily for @ successive months .", "sentence_id": 3}
+{"abstract_id": "25335329", "label": "methods", "text": "The bone mineral density ( BMD ) level was detected before treatment and at months @ after treatment .", "sentence_id": 4}
+{"abstract_id": "25335329", "label": "methods", "text": "Levels of bone alkaline phosphatase ( BALP ) , bone gla protein ( BGP ) , tartrate-resistant acid phosphatase ( TRAP ) , and C-terminal telopeptide of type II collagen ( CTX-II ) were detected by enzyme linked immunosorbent assay ( ELISA ) .", "sentence_id": 5}
+{"abstract_id": "25335329", "label": "methods", "text": "The drug safety was also assessed .", "sentence_id": 6}
+{"abstract_id": "25335329", "label": "results", "text": "Compared with before treatment , BMD of L@-@ and femur neck obviously increased in the treatment group at month @ after treatment ( P < @ ) , serum BALP and TRAP decreased ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25335329", "label": "results", "text": "Compared with before treatment , BMD of L@-@ and femur neck obviously decreased in the control group at month @ after treatment ( P < @ ) , serum BALP and TRAP increased ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25335329", "label": "results", "text": "Compared with the control group , lumbar and femur neck BMD obviously increased , serum levels of BGP and BALP obviously decreased , and serum levels of CTX-II and TRAP obviously increased in the treatment group at month @ after treatment ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25335329", "label": "results", "text": "No serious adverse event occurred during the treatment period .", "sentence_id": 10}
+{"abstract_id": "25335329", "label": "results", "text": "Bone fracture occurred in one case of the control group ( @ % ) .", "sentence_id": 11}
+{"abstract_id": "25335329", "label": "conclusions", "text": "SJR could attenuate bone loss of postmenopausal women with breast cancer who received AIs , increase BMD and improve abnormal bone metabolism .", "sentence_id": 12}
+{"abstract_id": "25488331", "label": "background", "text": "School-based influenza immunization can effectively address accessibility barriers , but injected inactivated influenza vaccines ( IIV ) may not be acceptable to some children and parents in school settings .", "sentence_id": 0}
+{"abstract_id": "25488331", "label": "objective", "text": "To better understand the feasibility of offering intranasal live attenuated influenza vaccines ( LAIV ) through schools , we assessed uptake , stakeholder acceptability , and cost of school-based delivery of LAIV compared to IIV .", "sentence_id": 1}
+{"abstract_id": "25488331", "label": "methods", "text": "We piloted an open-label cluster randomized trial involving @ elementary schools in Peterborough , Ontario during the @-@ influenza vaccination campaign .", "sentence_id": 2}
+{"abstract_id": "25488331", "label": "methods", "text": "Schools were randomized to having students receive IIV or LAIV at publicly-funded school-based clinics organized by the local public health department .", "sentence_id": 3}
+{"abstract_id": "25488331", "label": "methods", "text": "We measured the percentage of students vaccinated with at least one dose of influenza vaccine at school .", "sentence_id": 4}
+{"abstract_id": "25488331", "label": "methods", "text": "Stakeholder acceptability was evaluated through a questionnaire of parents and interviews of public health department personnel and school principals .", "sentence_id": 5}
+{"abstract_id": "25488331", "label": "methods", "text": "We compared the costs per dose of vaccine administered , including staff time and costs of vaccines and supplies .", "sentence_id": 6}
+{"abstract_id": "25488331", "label": "results", "text": "Single-dose influenza vaccine uptake was higher for the five schools offering LAIV than for the five offering IIV ( @ % vs. @ % , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25488331", "label": "results", "text": "Interviews with nine school principals and five public health department personnel suggested that the clinics ran smoothly with little disruption to school routines , and that LAIV was associated with increased efficiency and calmer children .", "sentence_id": 8}
+{"abstract_id": "25488331", "label": "results", "text": "All interviewees cited unfamiliarity with LAIV and the study recruitment package length as potential reasons for low uptake .", "sentence_id": 9}
+{"abstract_id": "25488331", "label": "results", "text": "The cost per vaccine dose administered was $ @ for IIV and $ @ for LAIV .", "sentence_id": 10}
+{"abstract_id": "25488331", "label": "conclusions", "text": "Use of LAIV in school-based clinics was associated with increased vaccine uptake and the perception among immunizing staff of reduced child anxiety , but also slightly higher vaccine administration costs , compared to IIV .", "sentence_id": 11}
+{"abstract_id": "25488331", "label": "conclusions", "text": "However , uptake was low for both groups .", "sentence_id": 12}
+{"abstract_id": "25488331", "label": "conclusions", "text": "More effective strategies to promote influenza vaccines and to obtain parent consent may improve vaccine uptake .", "sentence_id": 13}
+{"abstract_id": "25452229", "label": "objective", "text": "To assess the long-term effects of an intensive lifestyle intervention on physical function using a randomized post-test design in the Look AHEAD trial .", "sentence_id": 0}
+{"abstract_id": "25452229", "label": "methods", "text": "Overweight and obese ( BMI @ kg m ( -@ ) ) middle-aged and older adults ( aged @-@ years at enrollment ) with type @ diabetes ( n = @ ) at four clinics in Look AHEAD , a trial evaluating an intensive lifestyle intervention ( ILI ) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education ( DSE ) , underwent standardized assessments of performance-based physical function including an expanded short physical performance battery ( SPPBexp ) , @-m and @-m walk , and grip and knee extensor strength @ years post-randomization , during the trial 's weight maintenance phase .", "sentence_id": 1}
+{"abstract_id": "25452229", "label": "results", "text": "Eight years post-randomization , individuals randomized to ILI had better SPPBexp scores -LSB- adjusted mean ( SE ) difference : @ ( @ ) , P = @ -RSB- and faster @-m and @-m walk speeds -LSB- @ ( @ ) m s ( -@ ) , P = @ , and @ ( @ ) m s ( -@ ) , P = @ , respectively -RSB- compared to those randomized to DSE .", "sentence_id": 2}
+{"abstract_id": "25452229", "label": "results", "text": "Achieved weight loss greatly attenuated the group differences in physical function , and the intervention effect was no longer significant .", "sentence_id": 3}
+{"abstract_id": "25452229", "label": "conclusions", "text": "An intensive lifestyle intervention has long-term benefits for mobility function in overweight and obese middle-aged and older individuals with type @ diabetes .", "sentence_id": 4}
+{"abstract_id": "25496176", "label": "conclusions", "text": "Although children vaccinated with heptavalent pneumococcal conjugate vaccine ( PCV ) had fewer episodes of acute otitis media ( AOM ) , this trial was unable to prove a simultaneous decrease in nasopharyngeal carriage .", "sentence_id": 0}
+{"abstract_id": "25496176", "label": "objective", "text": "Carriage rates of AOM pathogens in the nasopharynx are high among children , and colonization is the first step towards infection .", "sentence_id": 1}
+{"abstract_id": "25496176", "label": "objective", "text": "The possible impact of PCV on carriage is therefore of interest , particularly in children with recurrent AOM .", "sentence_id": 2}
+{"abstract_id": "25496176", "label": "objective", "text": "The aims of this study were to examine the effect of heptavalent PCV on carriage of AOM pathogens in children at high risk of developing recurrent disease , and to monitor carriage of resistant pathogens in vaccinated and unvaccinated children .", "sentence_id": 3}
+{"abstract_id": "25496176", "label": "methods", "text": "A total of @ children with an onset of AOM before @ months of age , @ of whom developed recurrent disease , were enrolled in a trial .", "sentence_id": 4}
+{"abstract_id": "25496176", "label": "methods", "text": "Fifty-two children were vaccinated and all were closely monitored for @ years .", "sentence_id": 5}
+{"abstract_id": "25496176", "label": "results", "text": "There was no difference statistically between vaccinated children and controls concerning the carriage of any of the major AOM pathogens .", "sentence_id": 6}
+{"abstract_id": "25496176", "label": "results", "text": "There was evidence of within-child clustering for S. pneumoniae ( p = @ ) and H. influenzae ( p < @ ) , indicating that children continued to carry either species over time .", "sentence_id": 7}
+{"abstract_id": "25496176", "label": "results", "text": "Resistance rates were generally low and comparable with national levels .", "sentence_id": 8}
+{"abstract_id": "25953020", "label": "objective", "text": "Locoregional anesthesia is an effective method for evaluating cerebral function during carotid endarterectomy ( CEA ) .", "sentence_id": 0}
+{"abstract_id": "25953020", "label": "objective", "text": "Landmark-guided regional anesthesia ( RA ) is currently used for CEA and can provoke substantial perioperative hypertension .", "sentence_id": 1}
+{"abstract_id": "25953020", "label": "objective", "text": "Ultrasound-guided RA ( US-RA ) is a new method for performing RA in CEA ; however , the effect on sympathetic activity and blood pressure is uncertain .", "sentence_id": 2}
+{"abstract_id": "25953020", "label": "objective", "text": "This study assessed early sympathetic activity during CEA in US-RA compared with general anesthesia ( GA ) .", "sentence_id": 3}
+{"abstract_id": "25953020", "label": "methods", "text": "Patients were prospectively randomized to receive US-RA ( n = @ ) or GA ( n = @ ) for CEA .", "sentence_id": 4}
+{"abstract_id": "25953020", "label": "methods", "text": "The primary end point was the change in systolic arterial blood pressure after induction of anesthesia ( just before starting surgery ) comparing US-RA with GA. .", "sentence_id": 5}
+{"abstract_id": "25953020", "label": "methods", "text": "We also recorded heart rate and analyzed concentrations of plasma blood hormones , including cortisol , metanephrine , and normetanephrine at five different times .", "sentence_id": 6}
+{"abstract_id": "25953020", "label": "methods", "text": "Creatinine kinase , troponin I , and N-terminal pro-B-type natriuretic peptide were analyzed to detect potential changes in cardiac biomarkers during the procedure .", "sentence_id": 7}
+{"abstract_id": "25953020", "label": "results", "text": "Systolic arterial blood pressure ( mean standard deviation ) increased significantly in US-RA patients compared with GA patients even before surgery was initiated ( @ @ mm Hg vs @ @ mm Hg ; P < @ ) , then remained elevated during the entire surgery and returned to baseline values @ hour after admission to the postoperative anesthesia care unit .", "sentence_id": 8}
+{"abstract_id": "25953020", "label": "results", "text": "Heart rate ( US-RA : @ @ beats/min , GA : @ @ beats/min ; P < @ ) and cortisol levels ( US-RA : @ @ g/L , GA : @ @ g/L ; P = @ ) were also significantly higher in the US-RA group after induction of anesthesia .", "sentence_id": 9}
+{"abstract_id": "25953020", "label": "results", "text": "Other values did not differ .", "sentence_id": 10}
+{"abstract_id": "25953020", "label": "conclusions", "text": "The US-RA technique for CEA induces temporary intraoperative hypertension and an increase in stress hormone levels .", "sentence_id": 11}
+{"abstract_id": "25953020", "label": "conclusions", "text": "Nevertheless , US-RA is a feasible , effective , and safe form of locoregional for CEA that enables targeted placement of low volumes of local anesthesia under direct visualization .", "sentence_id": 12}
+{"abstract_id": "25884724", "label": "background", "text": "Adults living in the sunny Australian climate are at high risk of skin cancer , but vitamin D deficiency ( defined here as a serum @-hydroxyvitamin D ( @ ( OH ) D ) concentration of less than @ nmol/L ) is also common .", "sentence_id": 0}
+{"abstract_id": "25884724", "label": "background", "text": "Vitamin D deficiency may be a risk factor for a range of diseases .", "sentence_id": 1}
+{"abstract_id": "25884724", "label": "background", "text": "However , the optimal strategies to achieve and maintain vitamin D adequacy ( sun exposure , vitamin D supplementation or both ) , and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D , remain unclear .", "sentence_id": 2}
+{"abstract_id": "25884724", "label": "background", "text": "The Sun Exposure and Vitamin D Supplementation ( SEDS ) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency , and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function .", "sentence_id": 3}
+{"abstract_id": "25884724", "label": "methods", "text": "The SEDS Study is a multi-centre , randomised controlled trial of two different daily doses of vitamin D supplementation , and placebo , in conjunction with guidance on two different patterns of sun exposure .", "sentence_id": 4}
+{"abstract_id": "25884724", "label": "methods", "text": "Participants recruited from across Australia are aged @-@ years and have a recent vitamin D test result showing a serum @ ( OH ) D level of @-@ nmol/L .", "sentence_id": 5}
+{"abstract_id": "25884724", "label": "conclusions", "text": "This paper discusses the rationale behind the study design , and considers the challenges but necessity of data collection within a non-institutionalised adult population , in order to address the study aims .", "sentence_id": 6}
+{"abstract_id": "25884724", "label": "conclusions", "text": "We also discuss the challenges of participant recruitment and retention , ongoing engagement of referring medical practitioners and address issues of compliance and participant retention .", "sentence_id": 7}
+{"abstract_id": "24585423", "label": "objective", "text": "Patching of the operative eye is occasionally used in pediatric strabismus surgery .", "sentence_id": 0}
+{"abstract_id": "24585423", "label": "objective", "text": "The primary purpose of this study was to investigate the psychological and physiologic effects of patching after operation by multifactorial methods .", "sentence_id": 1}
+{"abstract_id": "24585423", "label": "methods", "text": "We analyzed the perioperative behaviors of @ children with strabismus conducted from June @ to July @ in this prospective longitudinal study .", "sentence_id": 2}
+{"abstract_id": "24585423", "label": "methods", "text": "The children were randomized into @ groups .", "sentence_id": 3}
+{"abstract_id": "24585423", "label": "methods", "text": "Patients in the patching group underwent postoperative patching and others received no patching .", "sentence_id": 4}
+{"abstract_id": "24585423", "label": "methods", "text": "Main outcome measures included The Faces Pain Scale-Revised score or numerical rating scales score , Children 's Hospital of Eastern Ontario Pain Scale ( CHEOPS ) score , crying time , and preoperative and postoperative physiologic parameters .", "sentence_id": 5}
+{"abstract_id": "24585423", "label": "results", "text": "Crying time was significantly longer in the patching group than in the no patching group , but self-report scores showed no difference in the groups .", "sentence_id": 6}
+{"abstract_id": "24585423", "label": "results", "text": "Repeated-measures analysis of variance on ranks revealed that postoperative CHEOPS score was lower in the no patching group than in the patching group , whereas no physiologic parameters were significantly different in the @ groups .", "sentence_id": 7}
+{"abstract_id": "24585423", "label": "conclusions", "text": "Patching is not necessary for reducing postoperative pain or the risk of infection in children undergoing strabismus surgery .", "sentence_id": 8}
+{"abstract_id": "25266425", "label": "objective", "text": "To assess the effect of a physical activity ( PA ) intervention on brain and behavioral indices of executive control in preadolescent children .", "sentence_id": 0}
+{"abstract_id": "25266425", "label": "methods", "text": "Two hundred twenty-one children ( @-@ years ) were randomly assigned to a @-month afterschool PA program or a wait-list control .", "sentence_id": 1}
+{"abstract_id": "25266425", "label": "methods", "text": "In addition to changes in fitness ( maximal oxygen consumption ) , electrical activity in the brain ( P@-ERP ) and behavioral measures ( accuracy , reaction time ) of executive control were collected by using tasks that modulated attentional inhibition and cognitive flexibility .", "sentence_id": 2}
+{"abstract_id": "25266425", "label": "results", "text": "Fitness improved more among intervention participants from pretest to posttest compared with the wait-list control ( @ mL/kg per minute , @ % confidence interval -LSB- CI -RSB- : @ to @ ; d = @ for group difference in pre-to-post change score ) .", "sentence_id": 3}
+{"abstract_id": "25266425", "label": "results", "text": "Intervention participants exhibited greater improvements from pretest to posttest in inhibition ( @ % , @ % CI : @ to @ ; d = @ ) and cognitive flexibility ( @ % , @ % CI : @ to @ ; d = @ for group difference in pre-to-post change score ) compared with control .", "sentence_id": 4}
+{"abstract_id": "25266425", "label": "results", "text": "Only the intervention group increased attentional resources from pretest to posttest during tasks requiring increased inhibition ( @ V , @ % CI : @ to @ ; d = @ ) and cognitive flexibility ( @ V , @ % CI : @ to @ ; d = @ ) .", "sentence_id": 5}
+{"abstract_id": "25266425", "label": "results", "text": "Finally , improvements in brain function on the inhibition task ( r = @ ) and performance on the flexibility task correlated with intervention attendance ( r = @ ) .", "sentence_id": 6}
+{"abstract_id": "25266425", "label": "conclusions", "text": "The intervention enhanced cognitive performance and brain function during tasks requiring greater executive control .", "sentence_id": 7}
+{"abstract_id": "25266425", "label": "conclusions", "text": "These findings demonstrate a causal effect of a PA program on executive control , and provide support for PA for improving childhood cognition and brain health .", "sentence_id": 8}
+{"abstract_id": "24567516", "label": "background", "text": "Recurrent and/or metastatic squamous cell carcinoma of the head and neck ( R/M-SCCHN ) overexpresses v@ integrin .", "sentence_id": 0}
+{"abstract_id": "24567516", "label": "background", "text": "Cilengitide selectively inhibits v@ and v@ integrins and is investigated as a treatment strategy .", "sentence_id": 1}
+{"abstract_id": "24567516", "label": "methods", "text": "The phase I/II study ADVANTAGE evaluated cilengitide combined with cisplatin , @-fluorouracil , and cetuximab ( PFE ) in R/M-SCCHN .", "sentence_id": 2}
+{"abstract_id": "24567516", "label": "methods", "text": "The phase II part reported here was an open-label , randomized , controlled trial investigating progression-free survival ( PFS ) .", "sentence_id": 3}
+{"abstract_id": "24567516", "label": "methods", "text": "Patients received up to six cycles of PFE alone or combined with cilengitide @ mg once ( CIL@W ) or twice ( CIL@W ) weekly .", "sentence_id": 4}
+{"abstract_id": "24567516", "label": "methods", "text": "Thereafter , patients received maintenance therapy ( cilengitide arms : cilengitide plus cetuximab ; PFE-alone arm : cetuximab only ) until disease progression or unacceptable toxicity .", "sentence_id": 5}
+{"abstract_id": "24567516", "label": "results", "text": "One hundred and eighty-two patients were treated .", "sentence_id": 6}
+{"abstract_id": "24567516", "label": "results", "text": "Median PFS per investigator read was similar for CIL@W + PFE , CIL@W + PFE , and PFE alone ( @ , @ , and @ months , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24567516", "label": "results", "text": "Accordingly , median overall survival and objective response rates were not improved with cilengitide ( @ months/@ % , @ months/@ % , and @ months/@ % , respectively ) .", "sentence_id": 8}
+{"abstract_id": "24567516", "label": "results", "text": "No clinically meaningful safety differences were observed between groups .", "sentence_id": 9}
+{"abstract_id": "24567516", "label": "results", "text": "None of the tested biomarkers ( expression of integrins , CD@ , Ki-@ , vascular endothelial growth factor receptor @ , vascular endothelial-cadherin , type IV collagen , epidermal growth factor receptor , or p@ for human papillomavirus ) were predictive of outcome .", "sentence_id": 10}
+{"abstract_id": "24567516", "label": "conclusions", "text": "Neither of the cilengitide-containing regimens demonstrated a PFS benefit over PFE alone in R/M-SCCHN patients .", "sentence_id": 11}
+{"abstract_id": "24942531", "label": "objective", "text": "The purpose of this secondary analysis was to determine changes in physical inactivity from baseline to @ years and to identify factors associated with and predictive of physical inactivity among individuals with type @ diabetes enrolled in the Detection of Ischemia in Asymptomatic Diabetics ( DIAD ) study .", "sentence_id": 0}
+{"abstract_id": "24942531", "label": "methods", "text": "DIAD was a prospective randomized screening trial that assessed the prevalence of silent ischemia in asymptomatic patients with type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "24942531", "label": "methods", "text": "Subjects were recruited from diabetes and primary care practices at @ centers throughout the United States and Canada .", "sentence_id": 2}
+{"abstract_id": "24942531", "label": "methods", "text": "This is a secondary data analysis of the physical activity data ( type and hours/week ) collected .", "sentence_id": 3}
+{"abstract_id": "24942531", "label": "methods", "text": "No intervention was conducted .", "sentence_id": 4}
+{"abstract_id": "24942531", "label": "results", "text": "In all subjects , physical inactivity rose from @ % at baseline to @ % at @ years ( S = @ ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24942531", "label": "results", "text": "This change was significant in both men ( S = @ ; P < @ ) , increasing from @ % to @ % , and women ( S = @ ; P < @ ) , increasing from @ % to @ % .", "sentence_id": 6}
+{"abstract_id": "24942531", "label": "results", "text": "Gender differences were noted in several factors associated with baseline physical inactivity as well as in factors predictive of physical inactivity at @ years .", "sentence_id": 7}
+{"abstract_id": "24942531", "label": "results", "text": "Important factors associated at both time points included lower level of education , current employment , presence of peripheral and autonomic neuropathy , and indicators of overweight/obesity .", "sentence_id": 8}
+{"abstract_id": "24942531", "label": "results", "text": "Baseline physical inactivity was strongly predictive of physical inactivity at @ years ( odds ratio , @ ; @ % confidence interval , @-@ @ ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24942531", "label": "conclusions", "text": "Gender-related differences were noted in factors associated with and predictive of physical inactivity .", "sentence_id": 10}
+{"abstract_id": "24774442", "label": "background", "text": "We have previously observed that intravaginal prasterone ( dehydroepiandrosterone , DHEA ) improved all domains of female sexual dysfunction ( FSD ) .", "sentence_id": 0}
+{"abstract_id": "24774442", "label": "objective", "text": "Investigate the influence of moderate/severe pain at sexual activity ( dyspareunia ) ( MSD ) at baseline on FSD following prasterone administration .", "sentence_id": 1}
+{"abstract_id": "24774442", "label": "methods", "text": "The effect of daily administration of prasterone ( @ , @ mg , @ mg or @mg ) for @ weeks on FSD in @ postmenopausal women with or without MSD at baseline was evaluated in a prospective , randomized , double-blind , and placebo-controlled phase III clinical trial .", "sentence_id": 2}
+{"abstract_id": "24774442", "label": "methods", "text": "Differences were examined on desire , arousal and orgasm .", "sentence_id": 3}
+{"abstract_id": "24774442", "label": "results", "text": "Comparable benefits were observed in women not having MSD ( n = @ ) vs. those having MSD ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24774442", "label": "results", "text": "The benefits over placebo in prasterone-treated women for desire , avoiding intimacy and vaginal dryness as well as for the total sexual domain of the MENQOL ( Menopause Specific Quality of Life ) questionnaire , ranged between @ % and @ % with P values of < @ or < @ except in one out of @ subgroups .", "sentence_id": 5}
+{"abstract_id": "24774442", "label": "results", "text": "For the arousal/sensation , arousal/lubrication and summary score of the ASF ( Abbreviated Sexual Function ) questionnaire , in the MSD + group , improvements of @ % ( P = @ ) , @ % ( P = @ ) and @ % ( P = @ ) were observed over placebo , respectively , while similar differences ( @ % , @ % and @ % ) did not reach statistical significance in the MSD - group having up to only @ prasterone-treated women compared with @ in the MSD + group .", "sentence_id": 6}
+{"abstract_id": "24774442", "label": "conclusions", "text": "No MSD at baseline does not apparently affect the effects of intravaginal prasterone on sexual dysfunction .", "sentence_id": 7}
+{"abstract_id": "24774442", "label": "conclusions", "text": "Knowing the absence of significant effects of estrogens on FSD , the present data suggest that vulvovaginal atrophy ( VVA ) and vulvovaginal sexual dysfunction ( VVSD ) are two different consequences of sex steroid deficiency at menopause which can respond independently .", "sentence_id": 8}
+{"abstract_id": "24774442", "label": "conclusions", "text": "In addition , the present data seriously question the justification of pain being part of FSD as well as the separation of FSD into separate domains .", "sentence_id": 9}
+{"abstract_id": "24309414", "label": "background", "text": "Supportive supervision is a form of supervision that promotes quality at all levels of health system by strengthening relationships within the system through prompt identification and resolution of problems among others .", "sentence_id": 0}
+{"abstract_id": "24309414", "label": "background", "text": "It is an effective intervention in improving health worker performance in low resource settings .", "sentence_id": 1}
+{"abstract_id": "24309414", "label": "background", "text": "Malaria is responsible for majority of outpatient consultations in Nigeria at all levels of care .", "sentence_id": 2}
+{"abstract_id": "24309414", "label": "methods", "text": "This was a facility-based interventional study with pre and post-intervention phases conducted among two groups.The study subjects were selected through a multistage sampling technique and data collection was done using both semistructured interviewer administered questionnaire and supervisory checklist .", "sentence_id": 3}
+{"abstract_id": "24309414", "label": "results", "text": "The mean knowledge scores of malaria within the intervention group showed an increase from @ @ at preintervention to @ @ at post-intervention ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24309414", "label": "results", "text": "The proportion of respondents who correctly followed malaria management guidelines increased from @ % at first supervisory visit to @ % by the third supervisory visit ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24309414", "label": "results", "text": "An analysis of the supervisory checklist showed improvement in performance of healthcare workers with each supportive supervisory visit in most of the variables examined .", "sentence_id": 6}
+{"abstract_id": "24309414", "label": "conclusions", "text": "This study has demonstrated that supportive supervision is a feasible and practicable tool in improving knowledge and practice of malaria case management among PHC workers .", "sentence_id": 7}
+{"abstract_id": "25027157", "label": "background", "text": "Functional neck/shoulder stiffness is one of the most well-known indications for acupuncture treatment in Japan .", "sentence_id": 0}
+{"abstract_id": "25027157", "label": "background", "text": "There is little evidence for the effectiveness of acupuncture treatment for functional neck/shoulder stiffness .", "sentence_id": 1}
+{"abstract_id": "25027157", "label": "background", "text": "Research using two different placebos may allow an efficient method to tease apart the components of real acupuncture from various kinds of ` non-specific ' effects such as ritual with touch or ritual alone .", "sentence_id": 2}
+{"abstract_id": "25027157", "label": "background", "text": "Herein , we describe a protocol of an ongoing , single-centre , randomised , placebo-controlled trial which aims to assess whether , in functional neck/shoulder stiffness , acupuncture treatment with skin piercing has a specific effect over two types of placebo : skin-touching plus ritual or ritual alone .", "sentence_id": 3}
+{"abstract_id": "25027157", "label": "methods", "text": "Six acupuncturists and @ patients with functional neck/shoulder stiffness are randomly assigned to four treatment groups : genuine acupuncture penetrating the skin , skin-touch placebo or no-touch placebo needles in a double-blind manner ( practitioner-patient blinding ) or no-treatment control group .", "sentence_id": 4}
+{"abstract_id": "25027157", "label": "methods", "text": "Each acupuncturist applies a needle to each of four acupoints ( Bladder@ , Small Intestine@ , Gallbladder@ and Bladder@ ) in the neck/shoulder to @ patients .", "sentence_id": 5}
+{"abstract_id": "25027157", "label": "methods", "text": "Before , immediately after and @ hours after the treatment , patients are asked about the intensity of their neck/shoulder stiffness .", "sentence_id": 6}
+{"abstract_id": "25027157", "label": "methods", "text": "After the treatment , practitioners and patients are asked to guess whether the treatment is `` penetrating '' , `` skin-touch '' or `` no-touch '' or to record `` can not identify the treatment '' .", "sentence_id": 7}
+{"abstract_id": "25027157", "label": "conclusions", "text": "In addition to intention-to-treat analysis , we will conduct subgroup analysis based on practitioners ' or patients ' guesses to discuss the efficacy and effectiveness of treatments with skin piercing and various placebo controls .", "sentence_id": 8}
+{"abstract_id": "25027157", "label": "conclusions", "text": "The results of practitioner and patient blinding will be discussed .", "sentence_id": 9}
+{"abstract_id": "25027157", "label": "conclusions", "text": "We believe this study will further distinguish the role of different components of acupuncture .", "sentence_id": 10}
+{"abstract_id": "25450993", "label": "objective", "text": "The aim of this study was to compare the effects of @ weeks of CT and AT , which training impulse ( total external workload and perceived exertion ) , are similar on power associated at VO@ peak ( pVO@ peak ) and cardiorespiratory responses of patient with CAD .", "sentence_id": 0}
+{"abstract_id": "25450993", "label": "methods", "text": "Eighteen male with CAD ( @ @ years , @ @ cm , @ @ kg , fraction of ejection = @ @ ) performed @ weeks of CT ( n = @ ) or AT ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25450993", "label": "methods", "text": "pVO@ peak , maximal and first ventilatory threshold values of oxygen uptake ( VO@ peak , VO@-vt ) and heart rate ( HRmax , HR-vt ) were measured before and after training session .", "sentence_id": 2}
+{"abstract_id": "25450993", "label": "methods", "text": "Total training impulse ( exercise rehabilitation and other paramedical actions ) were evaluated and harmonized between AT and CT according to Foster et al. formula ( @ ) RESULTS : No significant difference were found in training impulse between AT and CT ( @ @ vs @ @ U , P = NS ) .", "sentence_id": 3}
+{"abstract_id": "25450993", "label": "methods", "text": "VO@ pic increased after AT ( @ @ vs @ @ mL O@/min/kg , P < @ ) and remained unchanged after CT ( @ @ vs @ @ , P = NS ) .", "sentence_id": 4}
+{"abstract_id": "25450993", "label": "methods", "text": "Four weeks of training induced significant increase in pVO@ peak , VO@-vt and FC-vt , expressed in absolute or relative value ( P < @,@ ) , without any difference between AT and CT modalities ( P = NS ) .", "sentence_id": 5}
+{"abstract_id": "25450993", "label": "conclusions", "text": "Improving pVO@ pic following an exercise training does not necessarily preclude an improvement in coronary VO@ pic .", "sentence_id": 6}
+{"abstract_id": "25450993", "label": "conclusions", "text": "pVO@ peak was not improved with the same cardiorespiratory adaptations between AT and CT. .", "sentence_id": 7}
+{"abstract_id": "25450993", "label": "conclusions", "text": "Thus , there seems important to measure gas exchanges of subject with CAD during the incremental test and identify the respective part of muscular and cardiorespiratory functions in exercise exhaustion .", "sentence_id": 8}
+{"abstract_id": "24433682", "label": "background", "text": "The UK lags behind many European countries in terms of cancer survival .", "sentence_id": 0}
+{"abstract_id": "24433682", "label": "background", "text": "Initiatives to address this disparity have focused on barriers to presentation , symptom recognition , and referral for specialist investigation .", "sentence_id": 1}
+{"abstract_id": "24433682", "label": "background", "text": "Selection of patients for further investigation has come under particular scrutiny , although preferences for referral thresholds in the UK population have not been studied .", "sentence_id": 2}
+{"abstract_id": "24433682", "label": "background", "text": "We investigated preferences for diagnostic testing for colorectal , lung , and pancreatic cancers in primary-care attendees .", "sentence_id": 3}
+{"abstract_id": "24433682", "label": "methods", "text": "In a vignette-based study , researchers recruited individuals aged at least @ years attending @ general practices in three areas of England between Dec @ , @ , and Aug @ , @ .", "sentence_id": 4}
+{"abstract_id": "24433682", "label": "methods", "text": "Participants completed up to three of @ vignettes ( four for each of lung , pancreatic , and colorectal cancers ) , which were randomly assigned .", "sentence_id": 5}
+{"abstract_id": "24433682", "label": "methods", "text": "The vignettes outlined a set of symptoms , the risk that these symptoms might indicate cancer ( @ % , @ % , @ % , or @ % ) , the relevant testing process , probable treatment , possible alternative diagnoses , and prognosis if cancer were identified .", "sentence_id": 6}
+{"abstract_id": "24433682", "label": "methods", "text": "Participants were asked whether they would opt for diagnostic testing on the basis of the information in the vignette .", "sentence_id": 7}
+{"abstract_id": "24433682", "label": "results", "text": "@ participants completed @ vignettes .", "sentence_id": 8}
+{"abstract_id": "24433682", "label": "results", "text": "@ individuals ( @ % ) opted for investigation in their first vignette .", "sentence_id": 9}
+{"abstract_id": "24433682", "label": "results", "text": "We recorded no strong evidence that participants were more likely to opt for investigation with a @ % increase in risk of cancer ( odds ratio -LSB- OR -RSB- @ , @ % CI @-@ ; p = @ ) , although the association between risk and opting for investigation was strong when colorectal cancer was analysed alone ( @ , @-@ ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24433682", "label": "results", "text": "In multivariable analysis , age had an effect in all three cancer models : participants aged @-@ years were significantly more likely to opt for investigation than were those aged @-@ years , and those aged @ years or older were less likely .", "sentence_id": 11}
+{"abstract_id": "24433682", "label": "results", "text": "Other variables associated with increased likelihood of opting for investigation were shorter travel times to testing centre ( colorectal and lung cancers ) , a family history of cancer ( colorectal and lung cancers ) , and higher household income ( colorectal and pancreatic cancers ) .", "sentence_id": 12}
+{"abstract_id": "24433682", "label": "conclusions", "text": "Participants in our sample expressed a clear preference for diagnostic testing at all risk levels , and individuals want to be tested at risk levels well below those stipulated by UK guidelines .", "sentence_id": 13}
+{"abstract_id": "24433682", "label": "conclusions", "text": "This willingness should be considered during design of cancer pathways , particularly in primary care .", "sentence_id": 14}
+{"abstract_id": "24433682", "label": "conclusions", "text": "The public engagement with our study should encourage general practitioners to involve patients in referral decision making .", "sentence_id": 15}
+{"abstract_id": "24462735", "label": "objective", "text": "Little is known about the benefit of antiviral therapy for hepatitis B e antigen ( HBeAg ) - positive patients with high viral load and normal levels of alanine aminotransferase .", "sentence_id": 0}
+{"abstract_id": "24462735", "label": "objective", "text": "We evaluated the effects of single and combination therapies in immune-tolerant patients with chronic hepatitis B.", "sentence_id": 1}
+{"abstract_id": "24462735", "label": "methods", "text": "In a double-blind study , nucleos ( t ) ide-nave patients with high levels of hepatitis B virus ( HBV ) DNA who were positive for HBeAg and had normal levels of alanine aminotransferase were randomly assigned to groups given either oral tenofovir disoproxil fumarate ( TDF , @ mg ) and placebo ( n = @ ) or a combination of TDF ( @ mg ) and emtricitabine ( @ mg , n = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24462735", "label": "methods", "text": "The primary end point was proportion of patients with serum levels of HBV DNA < @ IU/mL at week @ .", "sentence_id": 3}
+{"abstract_id": "24462735", "label": "results", "text": "The study population ( mean age was @ years ; @ % were Asian ) was predominantly infected with HBV genotypes B and C ( @ % ) , @ % were HBeAg positive with a mean baseline level of HBV DNA of @ log@ IU/mL .", "sentence_id": 4}
+{"abstract_id": "24462735", "label": "results", "text": "At week @ , @ % of patients ( @ of @ ) in the TDF + placebo group and @ % of patients ( @ of @ ) in the TDF + emtricitabine group had levels of HBV DNA < @ IU/mL ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24462735", "label": "results", "text": "No patients were found to have viral resistance to therapy .", "sentence_id": 6}
+{"abstract_id": "24462735", "label": "results", "text": "HBeAg seroconversion occurred in @ patients ( @ % ) , all in the TDF + placebo group ; no patient had loss of hepatitis B surface antigen .", "sentence_id": 7}
+{"abstract_id": "24462735", "label": "results", "text": "In multivariate analysis , female sex ( odds ratio = @ ; P = @ ) and TDF + emtricitabine treatment ( odds ratio = @ ; P = @ ) were associated with a favorable response .", "sentence_id": 8}
+{"abstract_id": "24462735", "label": "results", "text": "Both regimens were well tolerated .", "sentence_id": 9}
+{"abstract_id": "24462735", "label": "conclusions", "text": "In HBeAg-positive patients with chronic HBV infection , high viral loads , normal levels of alanine aminotransferase , and therapy with the combination of TDF and emtricitabine provided better viral suppression than TDF alone , although rates of HBeAg seroconversion and hepatitis B surface antigen loss were low .", "sentence_id": 10}
+{"abstract_id": "25363100", "label": "background", "text": "Routine immunization is a key child survival intervention .", "sentence_id": 0}
+{"abstract_id": "25363100", "label": "background", "text": "Issues related to quality of service delivery pose operational challenges in delivering effective immunization services .", "sentence_id": 1}
+{"abstract_id": "25363100", "label": "background", "text": "Accumulated evidences suggest that `` supportive supervision '' improves the quality of health care services .", "sentence_id": 2}
+{"abstract_id": "25363100", "label": "background", "text": "During @-@ , Govt .", "sentence_id": 3}
+{"abstract_id": "25363100", "label": "background", "text": "of Odisha ( GoO ) and UNICEF jointly piloted this strategy in four districts to improve routine immunization .", "sentence_id": 4}
+{"abstract_id": "25363100", "label": "background", "text": "The present study aims to assess the effect of supportive supervision strategy on improvement of knowledge and practices on routine immunization among service providers .", "sentence_id": 5}
+{"abstract_id": "25363100", "label": "methods", "text": "We adopted a ` post-test only ' study design to compare the knowledge and practices of frontline health workers and their supervisors in four intervention districts with that of two control districts .", "sentence_id": 6}
+{"abstract_id": "25363100", "label": "methods", "text": "Altogether we interviewed @ supervisors and supervisees ( health workers ) , each , using semi-structured interview schedules .", "sentence_id": 7}
+{"abstract_id": "25363100", "label": "methods", "text": "We also directly observed @ ice lined refrigerator ( ILR ) points in both groups of districts .", "sentence_id": 8}
+{"abstract_id": "25363100", "label": "methods", "text": "The findings were compared with the baseline information , available only for the intervention districts .", "sentence_id": 9}
+{"abstract_id": "25363100", "label": "results", "text": "The health workers in the intervention districts displayed a higher knowledge score in selected items than in the control group .", "sentence_id": 10}
+{"abstract_id": "25363100", "label": "results", "text": "No significant difference in knowledge was observed between control and intervention supervisors .", "sentence_id": 11}
+{"abstract_id": "25363100", "label": "results", "text": "The management practices at ILR points on key routine immunization components were found to have improved significantly in intervention districts .", "sentence_id": 12}
+{"abstract_id": "25363100", "label": "conclusions", "text": "The observed improvements in the ILR management practices indicate positive influence of supportive supervision .", "sentence_id": 13}
+{"abstract_id": "25363100", "label": "conclusions", "text": "Higher level of domain knowledge among intervention health workers on specific items related to routine immunization could be due to successful transfer of knowledge from supervisors .", "sentence_id": 14}
+{"abstract_id": "25363100", "label": "conclusions", "text": "A ` pre-post ' study design should be undertaken to gain insights into the effectiveness of supportive supervision in improving routine immunization services .", "sentence_id": 15}
+{"abstract_id": "24356474", "label": "background", "text": "Previous global studies examined etanercept ( ETN ) + methotrexate ( MTX ) for treatment of rheumatoid arthritis ( RA ) , but included few subjects from Latin America .", "sentence_id": 0}
+{"abstract_id": "24356474", "label": "objective", "text": "The objective of this study was to compare the safety and efficacy of ETN + MTX versus a standard-of-care disease-modifying antirheumatic drug ( DMARD ) + MTX in Latin American subjects with moderate to severe active RA despite MTX therapy .", "sentence_id": 1}
+{"abstract_id": "24356474", "label": "methods", "text": "This open-label , active-comparator study ( NCT@ ) randomized subjects @:@ to ETN @ mg/wk + MTX or investigator-selected DMARD ( sulfasalazine or hydroxychloroquine ) + MTX ( ETN + MTX , n = @ ; DMARD + MTX , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24356474", "label": "methods", "text": "The primary end point was the proportion achieving American College of Rheumatology ( ACR ) @ at week @ .", "sentence_id": 3}
+{"abstract_id": "24356474", "label": "methods", "text": "Secondary end points included ACR@/@ , disease activity score ( DAS ) @ measures , and mean change in modified total Sharp score .", "sentence_id": 4}
+{"abstract_id": "24356474", "label": "methods", "text": "Patient-reported outcomes were the Health Assessment Questionnaire , @-item Short-Form , Hospital Anxiety and Depression Scale , Work Productivity and Activity Impairment : RA ( WPAI : RA ) , and Caregiver Burden and Resource Utilization .", "sentence_id": 5}
+{"abstract_id": "24356474", "label": "methods", "text": "Statistical analyses were stratified by country ; test and analysis of covariance were used .", "sentence_id": 6}
+{"abstract_id": "24356474", "label": "methods", "text": "Adverse events were monitored .", "sentence_id": 7}
+{"abstract_id": "24356474", "label": "results", "text": "More subjects achieved ACR@ at week @ with ETN + MTX versus DMARD + MTX ( @ % vs @ % , respectively ) , in addition to secondary end points ( P < @ for all ) ; mean change in modified total Sharp score was lower for the ETN + MTX group ( @ vs @ , respectively ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24356474", "label": "results", "text": "Improvements in patient-reported outcomes favored ETN + MTX for Health Assessment Questionnaire , @-item Short-Form , Hospital Anxiety and Depression Scale for depression , WPAI : RA , and Caregiver Burden and Resource Utilization emergency department visits for RA ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24356474", "label": "results", "text": "Overall , adverse events were similar between the groups ( @ % vs @ % , ) ; serious adverse events were also similar ( @ % vs @ % ) .", "sentence_id": 10}
+{"abstract_id": "24356474", "label": "results", "text": "The rate of overall infections was higher with ETN + MTX ( @ % ) than DMARD + MTX ( @ % , P @ ) .", "sentence_id": 11}
+{"abstract_id": "24356474", "label": "conclusions", "text": "Consistent with published global data among RA patients with inadequate response to MTX , adding ETN to MTX demonstrated better efficacy than adding one other conventional DMARD to MTX .", "sentence_id": 12}
+{"abstract_id": "24356474", "label": "conclusions", "text": "No new safety issues were observed .", "sentence_id": 13}
+{"abstract_id": "24356474", "label": "conclusions", "text": "ETN + MTX provided favorable benefit-risk profile among RA patients from LA region .", "sentence_id": 14}
+{"abstract_id": "24984211", "label": "background", "text": "Despite national guidelines recommending bone mineral density screening with dual-energy x-ray absorptiometry ( DXA ) in women aged @ years and older , many women do not receive initial screening .", "sentence_id": 0}
+{"abstract_id": "24984211", "label": "objective", "text": "To determine the effectiveness of health system and patient-level interventions designed to increase appropriate DXA testing and osteoporosis treatment through ( @ ) an invitation to self-refer for DXA ( self-referral ) ; ( @ ) self-referral plus patient educational materials ; and ( @ ) usual care ( UC , physician referral ) .", "sentence_id": 1}
+{"abstract_id": "24984211", "label": "methods", "text": "Parallel , group-randomized , controlled trials performed at Kaiser Permanente Northwest ( KPNW ) and Kaiser Permanente Georgia ( KPG ) .", "sentence_id": 2}
+{"abstract_id": "24984211", "label": "methods", "text": "Women aged @ years and older without a DXA in past @ years .", "sentence_id": 3}
+{"abstract_id": "24984211", "label": "methods", "text": "DXA completion rates @ days after intervention mailing and osteoporosis medication receipt @ days after initial intervention mailing .", "sentence_id": 4}
+{"abstract_id": "24984211", "label": "results", "text": "From > @,@ eligible women , those randomized to self-referral were significantly more likely to receive a DXA than UC ( @ % -@ % self-referral vs. @ % -@ % UC , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24984211", "label": "results", "text": "DXA rates did not significantly increase with patient educational materials .", "sentence_id": 6}
+{"abstract_id": "24984211", "label": "results", "text": "Osteoporosis was detected in a greater proportion of self-referral women compared with UC ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24984211", "label": "results", "text": "The number needed to receive an invitation to result in a DXA in KPNW and KPG regions was approximately @ and @ , respectively .", "sentence_id": 8}
+{"abstract_id": "24984211", "label": "results", "text": "New osteoporosis prescription rates were low ( @ % -@ % ) but significantly greater among self-referral versus UC in KPNW .", "sentence_id": 9}
+{"abstract_id": "24984211", "label": "conclusions", "text": "DXA rates significantly improved with a mailed invitation to schedule a scan without physician referral .", "sentence_id": 10}
+{"abstract_id": "24984211", "label": "conclusions", "text": "Providing women the opportunity to self-refer may be an effective , low-cost strategy to increase access for recommended osteoporosis screening .", "sentence_id": 11}
+{"abstract_id": "26042485", "label": "objective", "text": "Budesonide formoterol ( BF ) Spiromax is a breath-actuated dry-powder inhaler designed to deliver similar combinations of budesonide and formoterol as Symbicort Turbohaler .", "sentence_id": 0}
+{"abstract_id": "26042485", "label": "objective", "text": "We performed two studies to demonstrate pharmacokinetic ( PK ) equivalence of BF Spiromax with BF Turbohaler .", "sentence_id": 1}
+{"abstract_id": "26042485", "label": "methods", "text": "Two single-center , open-label , randomized , @-period crossover studies were performed .", "sentence_id": 2}
+{"abstract_id": "26042485", "label": "methods", "text": "The first study compared BF Spiromax @/@ @ g with BF Turbohaler @/@ g , while the second study compared BF Spiromax @/@ g with BF Turbohaler @/@ g. All treatments were administered with and without charcoal .", "sentence_id": 3}
+{"abstract_id": "26042485", "label": "methods", "text": "PK parameters were calculated by measuring plasma drug concentrations from blood samples taken pre-dose and up to @ hours post-dose .", "sentence_id": 4}
+{"abstract_id": "26042485", "label": "results", "text": "In each study , @ healthy volunteers were randomized .", "sentence_id": 5}
+{"abstract_id": "26042485", "label": "results", "text": "Bioequivalence of BF Spiromax with BF Turbohaler was demonstrated for budesonide and formoterol ( AUC@-t and Cmax ( @ % confidence intervals of the geometric mean between-device ratios for both parameters were within the predefined range of @-@ @ in both studies ) ) .", "sentence_id": 6}
+{"abstract_id": "26042485", "label": "results", "text": "Equivalence was observed without use of charcoal ( overall absorption post-inhalation ) and with charcoal ( pulmonary absorption ) .", "sentence_id": 7}
+{"abstract_id": "26042485", "label": "results", "text": "There were no major differences between treatments in tmax for either budesonide or formoterol .", "sentence_id": 8}
+{"abstract_id": "26042485", "label": "results", "text": "All study treatments were well tolerated ( one treatment-emergent adverse event ( TEAE ) in the medium-dose study and four TEAEs in the high-dose study ) .", "sentence_id": 9}
+{"abstract_id": "26042485", "label": "conclusions", "text": "These studies indicate that BF Spiromax ( charcoal block ) is bioequivalent to BF Turbohaler with respect to the PK parameters assessed .", "sentence_id": 10}
+{"abstract_id": "26042485", "label": "conclusions", "text": "Single doses of BF Spiromax were well tolerated ; the overall safety profile of BF Spiromax and BF Turbohaler was similar .", "sentence_id": 11}
+{"abstract_id": "25580060", "label": "background", "text": "Noncystic fibrosis bronchiectasis ( NCFB ) is characterized by airway expansion and recurrent acute exacerbations .", "sentence_id": 0}
+{"abstract_id": "25580060", "label": "background", "text": "Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases .", "sentence_id": 1}
+{"abstract_id": "25580060", "label": "objective", "text": "To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients with NCFB under steady state .", "sentence_id": 2}
+{"abstract_id": "25580060", "label": "methods", "text": "The study involved an open-label design in @ eligible Chinese patients with NCFB , who were assigned to control ( receiving no treatment ) and roxithromycin ( receiving @mg/day for @ months ) groups .", "sentence_id": 3}
+{"abstract_id": "25580060", "label": "methods", "text": "At baseline and @ months , the inflammatory markers such as interleukin - ( IL - ) @ , neutrophil elastase ( NE ) , matrix metalloproteinase - ( MMP ) @ , hyaluronidase ( HA ) , and type IV collagen in sputum were measured , along with the detection of dilated bronchus by throat computed tomography scan , and assessed the exacerbation .", "sentence_id": 4}
+{"abstract_id": "25580060", "label": "results", "text": "Forty-three patients completed the study .", "sentence_id": 5}
+{"abstract_id": "25580060", "label": "results", "text": "The neutrophil in the sputum was decreased in roxithromycin group compared with control ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25580060", "label": "results", "text": "IL-@ , NE , MMP-@ , HA , and type IV collagen in sputum were also decreased in roxithromycin group compared with the control group ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25580060", "label": "results", "text": "Airway thickness of dilated bronchus and exacerbation were reduced in roxithromycin group compared with the control ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25580060", "label": "conclusions", "text": "Roxithromycin can reduce airway inflammation and airway thickness of dilated bronchus in patients with NCFB .", "sentence_id": 9}
+{"abstract_id": "24442926", "label": "objective", "text": "CAM@ , a vehicle that forms a bioadhesive lipid barrier when applied to the oral mucosa , was developed as a carrier system for local delivery of benzydamine , an NSAID used for pain relief in oral mucositis .", "sentence_id": 0}
+{"abstract_id": "24442926", "label": "objective", "text": "This trial compared the analgesic effect of CAM@ plus benzydamine ( CAM@-benzydamine ) with unmedicated CAM@ ( CAM@-control ) for the treatment of oral mucositis in patients with head-and-neck cancer .", "sentence_id": 1}
+{"abstract_id": "24442926", "label": "methods", "text": "Thirty-eight study participants were enrolled during their @rd to @th week of radiation therapy .", "sentence_id": 2}
+{"abstract_id": "24442926", "label": "methods", "text": "Participants were required to have symptomatic oral mucositis ( WHO Grade @ or above ) at screening and pain scores of at least @ on an @-point Likert scale at screening and on each day before treatment with study medication .", "sentence_id": 3}
+{"abstract_id": "24442926", "label": "methods", "text": "After undergoing radiation , patients were administered a single dose of CAM@-control or CAM@-benzydamine @ days apart , in a randomized crossover fashion .", "sentence_id": 4}
+{"abstract_id": "24442926", "label": "methods", "text": "Pain was assessed over the following @ h.", "sentence_id": 5}
+{"abstract_id": "24442926", "label": "results", "text": "With both treatments , patients experienced a mean @ % decrease in pain intensity at @ h ( the primary study endpoint ) .", "sentence_id": 6}
+{"abstract_id": "24442926", "label": "results", "text": "Both treatments resulted in significant pain relief within @ min of application that was evident during the entire @-h assessment period .", "sentence_id": 7}
+{"abstract_id": "24442926", "label": "results", "text": "There was no difference in pain relief between the two interventions at any time point .", "sentence_id": 8}
+{"abstract_id": "24442926", "label": "results", "text": "Both treatments were safe and well tolerated .", "sentence_id": 9}
+{"abstract_id": "24442926", "label": "conclusions", "text": "CAM@-benzydamine and CAM@-control were both efficacious in reducing pain in patients with oral mucositis related to radiation therapy for head-and-neck cancer .", "sentence_id": 10}
+{"abstract_id": "24442926", "label": "conclusions", "text": "Analgesic effects of both medications were immediate , clinically significant , and persistent for up to @ h.", "sentence_id": 11}
+{"abstract_id": "24519752", "label": "objective", "text": "The aim of this study was to characterize trastuzumab population pharmacokinetics ( PKs ) in patients with human epidermal growth factor receptor @-positive advanced gastric or gastroesophageal junction cancer and the relationship of trastuzumab PK with patient response .", "sentence_id": 0}
+{"abstract_id": "24519752", "label": "methods", "text": "A nonlinear mixed effects PK model was built using data from the ToGA study .", "sentence_id": 1}
+{"abstract_id": "24519752", "label": "methods", "text": "Patients were randomized to intravenous trastuzumab plus chemotherapy or chemotherapy alone .", "sentence_id": 2}
+{"abstract_id": "24519752", "label": "methods", "text": "The influence of demographic , laboratory , and disease characteristics on PK parameters was assessed .", "sentence_id": 3}
+{"abstract_id": "24519752", "label": "methods", "text": "An exploratory exposure-response analysis compared various PK parameters at steady state with best overall tumor response and overall survival ( OS ) .", "sentence_id": 4}
+{"abstract_id": "24519752", "label": "results", "text": "Trastuzumab PK was best described by a two-compartment model with parallel linear and nonlinear ( Michaelis-Menten ) elimination from the central compartment .", "sentence_id": 5}
+{"abstract_id": "24519752", "label": "results", "text": "Total clearance ( and half-life ) of trastuzumab was concentration-dependent .", "sentence_id": 6}
+{"abstract_id": "24519752", "label": "results", "text": "Body weight , prior gastrectomy , and serum albumin had the greatest influence on trastuzumab PK ; increasing weight and decreasing albumin levels were associated with increased clearance , while prior gastrectomy correlated with decreased clearance .", "sentence_id": 7}
+{"abstract_id": "24519752", "label": "results", "text": "Median values for AUC , Cmax , and Cmin were lower in patients with progressive disease ( PD ) than other response categories , although the @ interquartile ranges overlapped .", "sentence_id": 8}
+{"abstract_id": "24519752", "label": "results", "text": "Patients with the lowest Cmin had the highest PD rate and a shorter OS .", "sentence_id": 9}
+{"abstract_id": "24519752", "label": "conclusions", "text": "In the advanced gastric cancer population , trastuzumab PK was best described by a two-compartment model with parallel linear and nonlinear elimination .", "sentence_id": 10}
+{"abstract_id": "24519752", "label": "conclusions", "text": "Predicted PK exposure was lower than previously reported for breast cancer .", "sentence_id": 11}
+{"abstract_id": "24519752", "label": "conclusions", "text": "Patients with the lowest Cmin had a shorter OS and the highest PD rate , but a distinct correlation was not observed for tumor response .", "sentence_id": 12}
+{"abstract_id": "24567266", "label": "background", "text": "Whilst surgery will face an imminent workforce shortage , an increasing majority of students decide against a surgical career .", "sentence_id": 0}
+{"abstract_id": "24567266", "label": "background", "text": "This study evaluated the current career expectations of medical students and tested a hands-on virtual reality ( VR ) intervention as a tool to increase their interest in surgery .", "sentence_id": 1}
+{"abstract_id": "24567266", "label": "methods", "text": "Randomly selected medical students of the University of Basel received a short questionnaire to rank their interest in five different postgraduate working environments prior to a lecture .", "sentence_id": 2}
+{"abstract_id": "24567266", "label": "methods", "text": "After the lecture they participated in a hands-on VR demonstration .", "sentence_id": 3}
+{"abstract_id": "24567266", "label": "methods", "text": "Thereafter an online questionnaire regarding workplace expectations , surgery and VR was sent to the students .", "sentence_id": 4}
+{"abstract_id": "24567266", "label": "results", "text": "The online questionnaire response rate was @ % ( @/@ ) .", "sentence_id": 5}
+{"abstract_id": "24567266", "label": "results", "text": "Before using the VR intervention , a nonsurgical career was preferred by the majority of students , followed by a surgical career , cross-disciplinary specialties , research and , finally , nonclinical work .", "sentence_id": 6}
+{"abstract_id": "24567266", "label": "results", "text": "Surgery ( n = @ , @ % ) and emergency medicine ( n = @ , @ % ) were rated as incompatible with a good work-life balance .", "sentence_id": 7}
+{"abstract_id": "24567266", "label": "results", "text": "Further drawbacks to surgery were apprehension of competitive mentality , unclear career perspectives and longer working hours .", "sentence_id": 8}
+{"abstract_id": "24567266", "label": "results", "text": "The VR intervention had limited impact on re-ranking the five working sectors and slightly increased the students ' interest in surgery .", "sentence_id": 9}
+{"abstract_id": "24567266", "label": "conclusions", "text": "Students ' work environment expectations , their declining interest in a surgical career and the increasing need for surgeons represent challenges for surgical societies to address , in order to improve the attractiveness of surgery amongst students .", "sentence_id": 10}
+{"abstract_id": "24567266", "label": "conclusions", "text": "VR sessions may be integrated as part of the actions required to improve students ' interest in a surgical career and should be further evaluated within controlled study designs .", "sentence_id": 11}
+{"abstract_id": "24512909", "label": "objective", "text": "The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for ulcerative colitis ( UC ) have not been evaluated previously .", "sentence_id": 0}
+{"abstract_id": "24512909", "label": "methods", "text": "This randomized , double-blind trial evaluated the efficacy and safety of @ weeks of treatment with infliximab monotherapy , azathioprine monotherapy , or the @ drugs combined in tumor necrosis factor-a antagonist-naive adults with moderate to severe UC .", "sentence_id": 1}
+{"abstract_id": "24512909", "label": "methods", "text": "Patients were assigned randomly to receive intravenous infusions of infliximab @ mg/kg at weeks @ , @ , @ , and @ plus daily oral placebo capsules ; oral azathioprine @ mg/kg daily plus placebo infusions on the infliximab schedule ; or combination therapy with the @ drugs .", "sentence_id": 2}
+{"abstract_id": "24512909", "label": "methods", "text": "Corticosteroid-free clinical remission ( primary end point , week @ ) was evaluated at weeks @ and @ .", "sentence_id": 3}
+{"abstract_id": "24512909", "label": "methods", "text": "The study was terminated before the enrollment target was reached .", "sentence_id": 4}
+{"abstract_id": "24512909", "label": "results", "text": "A total of @ patients were included in efficacy analyses .", "sentence_id": 5}
+{"abstract_id": "24512909", "label": "results", "text": "Baseline characteristics were similar between treatment groups .", "sentence_id": 6}
+{"abstract_id": "24512909", "label": "results", "text": "Corticosteroid-free remission at week @ was achieved by @ % ( @ of @ ) of patients receiving infliximab/azathioprine , compared with @ % ( @ of @ ) receiving infliximab alone ( P = @ ) and @ % ( @ of @ ) receiving azathioprine alone ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24512909", "label": "results", "text": "Mucosal healing at week @ occurred in @ % ( @ of @ ) of patients receiving infliximab/azathioprine , compared with @ % ( @ of @ ) receiving infliximab ( P = @ ) and @ % ( @ of @ ) receiving azathioprine ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24512909", "label": "results", "text": "Serious infections occurred in @ patients ( @ patient receiving infliximab , and @ patient receiving azathioprine ) .", "sentence_id": 9}
+{"abstract_id": "24512909", "label": "conclusions", "text": "Antitumor necrosis factor-anaive patients with moderate to severe UC treated with infliximab plus azathioprine were more likely to achieve corticosteroid-free remission at @ weeks than those receiving either monotherapy .", "sentence_id": 10}
+{"abstract_id": "24512909", "label": "conclusions", "text": "Combination therapy led to significantly better mucosal healing than azathioprine monotherapy .", "sentence_id": 11}
+{"abstract_id": "24512909", "label": "conclusions", "text": "ClinicalTrials.gov number , NCT@ .", "sentence_id": 12}
+{"abstract_id": "24719128", "label": "objective", "text": "Prolonged duration of cardiopulmonary bypass aggravates the degree of inflammation and coagulopathy .", "sentence_id": 0}
+{"abstract_id": "24719128", "label": "objective", "text": "We investigated the influence of @ % hydroxyethyl starch ( HES ) @/@ @ on coagulation and inflammation compared with albumin when used for both cardiopulmonary bypass priming and perioperative fluid therapy in patients undergoing complex valvular heart surgery .", "sentence_id": 1}
+{"abstract_id": "24719128", "label": "methods", "text": "Fifty four patients were randomly allocated into albumin-HES , albumin-nonHES , and HES-HES groups .", "sentence_id": 2}
+{"abstract_id": "24719128", "label": "methods", "text": "The cardiopulmonary bypass circuit was primed with @ % albumin in the albumin-HES and albumin-nonHES group , and with HES in the HES-HES group .", "sentence_id": 3}
+{"abstract_id": "24719128", "label": "methods", "text": "As perioperative fluid , only plasmalyte was used in the albumin-nonHES group whereas HES was used up to @ mL/kg in the albumin-HES and albumin-HES group .", "sentence_id": 4}
+{"abstract_id": "24719128", "label": "methods", "text": "Serial assessments of coagulation profiles using the rotational thromboelastometry and inflammatory markers ( tissue necrosis factor - , interleukin-@ , and interleukin-@ ) were performed .", "sentence_id": 5}
+{"abstract_id": "24719128", "label": "results", "text": "Patients ' characteristics and the duration of cardiopulmonary bypass ( albumin-HES ; @ min , HES-HES ; @ min , albumin-nonHES ; @ min ) were all similar among the groups .", "sentence_id": 6}
+{"abstract_id": "24719128", "label": "results", "text": "Postoperative coagulation profiles demonstrated sporadic increases in clot formation time and coagulation time , without any differences in the actual amount of perioperative bleeding and transfusion requirements among the groups .", "sentence_id": 7}
+{"abstract_id": "24719128", "label": "results", "text": "Also , inflammatory markers showed significant activation after cardiopulmonary bypass without any differences among the groups .", "sentence_id": 8}
+{"abstract_id": "24719128", "label": "conclusions", "text": "Even in the presence of prolonged duration of cardiopulmonary bypass , HES seemed to yield similar influence on the ensuing coagulopathy and inflammatory response when used for priming and perioperative fluid therapy following complex valvular heart surgery compared with conventional fluid regimen including albumin and plasmalyte .", "sentence_id": 9}
+{"abstract_id": "24307559", "label": "objective", "text": "To assess the reproducibility of brain-activation and eye-movement patterns in a saccade paradigm when comparing subjects , tasks , and magnetic resonance ( MR ) systems .", "sentence_id": 0}
+{"abstract_id": "24307559", "label": "methods", "text": "Forty-five healthy adults at two different sites ( n = @ ) performed saccade tasks with varying levels of target predictability : predictable ( PRED ) , position predictable ( pPRED ) , time predictable ( tPRED ) , and prosaccade ( SAC ) .", "sentence_id": 1}
+{"abstract_id": "24307559", "label": "methods", "text": "Eye-movement pattern was tested with a repeated-measures analysis of variance .", "sentence_id": 2}
+{"abstract_id": "24307559", "label": "methods", "text": "Activation maps reproducibility were estimated with the cluster overlap Jaccard index and signal variance coefficient of determination for within-subjects test-retest data , and for between-subjects data from the same and different sites .", "sentence_id": 3}
+{"abstract_id": "24307559", "label": "results", "text": "In all groups latencies increased with decreasing target predictability : PRED < pPRED < tPRED < SAC ( P < @,@ ) .", "sentence_id": 4}
+{"abstract_id": "24307559", "label": "results", "text": "Activation overlap was good to fair ( > @ ) in all tasks in the within-subjects test-retest comparisons and poor ( < @ ) in the tPRED for different subjects .", "sentence_id": 5}
+{"abstract_id": "24307559", "label": "results", "text": "The overlap of the different tasks for within-groups data was higher ( @-@ @ ) than for the between-groups data ( @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24307559", "label": "results", "text": "Activation consistency was @-@ % in the same subjects , @-@ % in different subjects , and @-@ % in different sites .", "sentence_id": 7}
+{"abstract_id": "24307559", "label": "results", "text": "In SAC , the activation found in the same and in different subjects was more consistent than in other tasks ( @-@ % ) .", "sentence_id": 8}
+{"abstract_id": "24307559", "label": "conclusions", "text": "The predictive saccade tasks produced evidence for brain-activation and eye-movement reproducibility .", "sentence_id": 9}
+{"abstract_id": "24971591", "label": "objective", "text": "The cortisol awakening response ( CAR ) is a natural metabolic response that can be potentiated by negative cognitive-emotional processes , including stress appraisals , negative affect , and rumination .", "sentence_id": 0}
+{"abstract_id": "24971591", "label": "objective", "text": "Psychological distress and the CAR are not consistently related , however .", "sentence_id": 1}
+{"abstract_id": "24971591", "label": "objective", "text": "Individual differences in aspects of dispositional mindfulness which reflect how people relate to negative thoughts and emotions may help explain such inconsistencies .", "sentence_id": 2}
+{"abstract_id": "24971591", "label": "objective", "text": "We tested whether the tendency to ( @ ) label and describe inner experiences and ( @ ) accept negative thoughts and feelings without judgment moderated the association between psychological distress and the CAR .", "sentence_id": 3}
+{"abstract_id": "24971591", "label": "methods", "text": "Self-reported dispositional mindfulness , perceived stress , anxiety , negative affect , rumination , and the CAR were assessed among overweight/obese women .", "sentence_id": 4}
+{"abstract_id": "24971591", "label": "methods", "text": "Regression analyses were conducted to examine whether dispositional mindfulness moderated the relationship between indicators of psychological distress and the CAR .", "sentence_id": 5}
+{"abstract_id": "24971591", "label": "results", "text": "While psychological distress was consistently positively related to the CAR , these associations were qualified by significant interactions with both components of dispositional mindfulness .", "sentence_id": 6}
+{"abstract_id": "24971591", "label": "results", "text": "Psychological distress was associated with the CAR at lower levels of dispositional mindfulness but not at higher levels .", "sentence_id": 7}
+{"abstract_id": "24971591", "label": "conclusions", "text": "These findings are consistent with the idea that the tendency to describe and accept experiences may buffer the impact of psychological distress on physiological arousal .", "sentence_id": 8}
+{"abstract_id": "24971591", "label": "conclusions", "text": "These metacognitive processes may be important moderators in unraveling the complex relationship between psychological distress and physiological stress reactivity .", "sentence_id": 9}
+{"abstract_id": "24971591", "label": "conclusions", "text": "Further research is recommended to replicate this approach in other populations .", "sentence_id": 10}
+{"abstract_id": "24471750", "label": "objective", "text": "To evaluate intra-articular autologous protein solution ( APS ) for the treatment of osteoarthritis in horses .", "sentence_id": 0}
+{"abstract_id": "24471750", "label": "objective", "text": "Animals-@ client-owned horses with naturally occuring osteoarthritis .", "sentence_id": 1}
+{"abstract_id": "24471750", "label": "methods", "text": "APS was generated from a dual-device system that concentrated plasma and WBC proteins and enriched platelet growth factors .", "sentence_id": 2}
+{"abstract_id": "24471750", "label": "methods", "text": "Horses were randomly assigned to receive an intra-articular injection of @ mL of saline ( @ % NaCl ) solution ( n = @ ) or APS ( @ ) , exercised on a treadmill , and evaluated on the basis of lameness grades , kinetic gait analysis , joint circumference , and range of motion for @ days .", "sentence_id": 3}
+{"abstract_id": "24471750", "label": "methods", "text": "Horses that received saline solution were administered APS at termination of the study , and clients scored horses for lameness and discomfort before , @ weeks after , and @ weeks after the APS injection .", "sentence_id": 4}
+{"abstract_id": "24471750", "label": "results", "text": "The APS group had significant improvements in lameness grade , asymmetry indices of vertical peak force , and range of joint motion by @ days , compared with baseline or control group values .", "sentence_id": 5}
+{"abstract_id": "24471750", "label": "results", "text": "No adverse effects associated with APS treatment were evident .", "sentence_id": 6}
+{"abstract_id": "24471750", "label": "results", "text": "Clients assessed lameness and comfort as improved at @ and @ weeks .", "sentence_id": 7}
+{"abstract_id": "24471750", "label": "results", "text": "The APS had greater likelihood ( OR , @ to @ ) of a therapeutic response in horses with a lameness score < @ , < @ % vertical force asymmetry , or absence of marked osteophyte formation , subchondral sclerosis , or joint space narrowing .", "sentence_id": 8}
+{"abstract_id": "24471750", "label": "results", "text": "Concentration of interleukin-@ receptor antagonist in APS was @ times that in blood .", "sentence_id": 9}
+{"abstract_id": "24471750", "label": "conclusions", "text": "Intra-articular administration of APS can be considered an effective treatment option for equine osteoarthritis , with the potential for disease-modifying effects .", "sentence_id": 10}
+{"abstract_id": "25897039", "label": "background", "text": "Consistent evidence suggests that obstructive sleep apnoea ( OSA ) is associated with increased cardiovascular risk .", "sentence_id": 0}
+{"abstract_id": "25897039", "label": "background", "text": "However , it is unclear whether OSA is underdiagnosed in the cardiology outpatient setting .", "sentence_id": 1}
+{"abstract_id": "25897039", "label": "background", "text": "In the present study , we prospectively evaluated the potential underdiagnosis of OSA in several subspecialties from a tertiary cardiology university hospital .", "sentence_id": 2}
+{"abstract_id": "25897039", "label": "methods", "text": "Consecutive outpatients from five subspecialties ( hypertension , coronary , arrhythmia , heart failure ( HF ) , valvular heart disease ) were studied .", "sentence_id": 3}
+{"abstract_id": "25897039", "label": "methods", "text": "We performed anthropometric measurements , assessed the risk of OSA using the Berlin Questionnaire and evaluated the prior diagnosis and treatment for OSA .", "sentence_id": 4}
+{"abstract_id": "25897039", "label": "methods", "text": "In a subset of patients randomly selected , we performed portable sleep monitoring to objectively evaluate the presence of OSA ( defined by an apnoea-hypopnoea index @ events/h of sleep ) .", "sentence_id": 5}
+{"abstract_id": "25897039", "label": "results", "text": "We evaluated @ patients ( @ from each subspecialty ) .", "sentence_id": 6}
+{"abstract_id": "25897039", "label": "results", "text": "The mean age and body mass index ( BMI ) were @years and @ kg/m ( @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "25897039", "label": "results", "text": "We found that @ % ( @ patients ) had a high risk for OSA ( Berlin Questionnaire ) .", "sentence_id": 8}
+{"abstract_id": "25897039", "label": "results", "text": "However , only @ ( @ % ) of these patients had a previous diagnosis of OSA .", "sentence_id": 9}
+{"abstract_id": "25897039", "label": "results", "text": "Of those , only six patients were receiving specific OSA treatment .", "sentence_id": 10}
+{"abstract_id": "25897039", "label": "results", "text": "Fifty patients ( @ from each specialty ) participated in sleep studies .", "sentence_id": 11}
+{"abstract_id": "25897039", "label": "results", "text": "No differences were found in patients who underwent sleep monitoring and those who did not .", "sentence_id": 12}
+{"abstract_id": "25897039", "label": "results", "text": "We found a high frequency of OSA ( @ % ) , varying from @ % ( hypertension group ) to @ % ( HF group ) .", "sentence_id": 13}
+{"abstract_id": "25897039", "label": "conclusions", "text": "Despite significant scientific evidence pointing to OSA as an emerging cardiovascular risk factor , OSA is still underdiagnosed in several cardiology subspecialties .", "sentence_id": 14}
+{"abstract_id": "24835303", "label": "objective", "text": "To compare two concentrations of ropivacaine administered for tumescent local anesthesia ( TLA ) in dogs undergoing mastectomy .", "sentence_id": 0}
+{"abstract_id": "24835303", "label": "methods", "text": "Prospective randomized clinical study .", "sentence_id": 1}
+{"abstract_id": "24835303", "label": "methods", "text": "Seventeen bitches of various breeds , aged @years and weighing @ kg requiring total unilateral or bilateral mastectomy .", "sentence_id": 2}
+{"abstract_id": "24835303", "label": "methods", "text": "Dogs were premedicated with acepromazine ( @ mgkg ( -@ ) ) and morphine ( @ mgkg ( -@ ) ) intramuscularly .", "sentence_id": 3}
+{"abstract_id": "24835303", "label": "methods", "text": "Anesthesia was induced with propofol ( @ mgkg ( -@ ) ) and midazolam ( @ mgkg ( -@ ) ) intravenously , followed by intubation and maintenance with isoflurane and TLA .", "sentence_id": 4}
+{"abstract_id": "24835303", "label": "methods", "text": "Dogs were randomly allocated to receive TLA either with @ % ropivacaine ( group G@ ) or with @ % ropivacaine ( group G@ ) .", "sentence_id": 5}
+{"abstract_id": "24835303", "label": "methods", "text": "TLA was performed by insertion of a multihole needle under the skin and infusion of ropivacaine and lactated Ringer 's solution at a fixed volume of @mLkg ( -@ ) .", "sentence_id": 6}
+{"abstract_id": "24835303", "label": "methods", "text": "Ropivacaine concentrations in arterial blood were measured by high-performance liquid chromatography .", "sentence_id": 7}
+{"abstract_id": "24835303", "label": "methods", "text": "Post-operative pain was assessed using two scales ( University of Melbourne pain scale and a modified composite measure pain scale ) and von Frey filaments , @hours after TLA and at @hour intervals until sensitivity was regained .", "sentence_id": 8}
+{"abstract_id": "24835303", "label": "methods", "text": "A score above @ % of the maximum possible score was considered a positive indicator of pain .", "sentence_id": 9}
+{"abstract_id": "24835303", "label": "results", "text": "Peak plasma concentrations of ropivacaine were measured @minutes after TLA in G@ .", "sentence_id": 10}
+{"abstract_id": "24835303", "label": "results", "text": "Low concentrations were measured in G@ for @minutes , with subsequent increase .", "sentence_id": 11}
+{"abstract_id": "24835303", "label": "results", "text": "Analgesic rescue and return of sensitivity occurred at @ and @ hours ( mean SD ) after TLA for G@ and G@ , respectively .", "sentence_id": 12}
+{"abstract_id": "24835303", "label": "conclusions", "text": "Tumescent local anesthesia with ropivacaine provided satisfactory post-operative analgesia that lasted for several hours , with no difference in duration between the concentrations .", "sentence_id": 13}
+{"abstract_id": "24835303", "label": "conclusions", "text": "No serious side effects were attributed to TLA .", "sentence_id": 14}
+{"abstract_id": "24835303", "label": "conclusions", "text": "Results indicated that @ % ropivacaine provided adequate analgesia for mastectomy , however , more studies are required to support this conclusion .", "sentence_id": 15}
+{"abstract_id": "24562806", "label": "objective", "text": "ST-segment resolution ( STR ) after reperfusion therapy has been shown to correlate with prognosis in patients with ST-segment elevation myocardial infarction ( STEMI ) .", "sentence_id": 0}
+{"abstract_id": "24562806", "label": "objective", "text": "We investigated whether acute ECG measurements also correlate with ultimate infarct size .", "sentence_id": 1}
+{"abstract_id": "24562806", "label": "results", "text": "The INFUSE-AMI trial randomized @ patients with anterior STEMI to intracoronary bolus abciximab vs. no abciximab , and to thrombus aspiration vs. no aspiration .", "sentence_id": 2}
+{"abstract_id": "24562806", "label": "results", "text": "Infarct size as percentage of total LV mass was calculated by cardiac magnetic resonance imaging ( MRI ) @ days post intervention .", "sentence_id": 3}
+{"abstract_id": "24562806", "label": "results", "text": "Five ECG methods were analysed for their ability to predict MRI infarct mass : ( @ ) summed STR across all infarct-related ECG leads ( STR ) ; ( @ ) STR in the single lead with maximum baseline ST-segment elevation ( maxSTR ) ; ( @ ) summed residual ST-segment elevation across all infarct-related leads at @ min post intervention ( ST residual ) ; ( @ ) maximum residual ST-segment elevation in the worst single lead at @ min post intervention ( maxST residual ) ; ( @ ) number of new significant Q-waves ( Qwave ) at @ min .", "sentence_id": 4}
+{"abstract_id": "24562806", "label": "results", "text": "All ECG methods strongly correlated with @-day MRI infarct mass ( all p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24562806", "label": "results", "text": "Simpler ECG measurements such as maxSTresidual and Qwave were as predictive as more complex measurements .", "sentence_id": 6}
+{"abstract_id": "24562806", "label": "results", "text": "A subset analysis of @ patients who had microvascular obstruction ( MVO ) determined by MRI @ days post intervention also showed strong correlations of MVO with the ECG measures .", "sentence_id": 7}
+{"abstract_id": "24562806", "label": "conclusions", "text": "ST-segment and Q-wave changes after primary PCI in anterior STEMI strongly correlated with @-day infarct size by MRI .", "sentence_id": 8}
+{"abstract_id": "24562806", "label": "conclusions", "text": "In particular , maxST residual and Qwave at @ min are simple ECG parameters that offer rapid analysis for prognostication .", "sentence_id": 9}
+{"abstract_id": "25095886", "label": "background", "text": "The quality of evidence for invasive revascularization in intermittent claudication is low or very low .", "sentence_id": 0}
+{"abstract_id": "25095886", "label": "background", "text": "This prospective , randomized , controlled study tested the hypothesis that an invasive treatment strategy versus continued noninvasive treatment improves health-related quality of life after @ year in unselected patients with intermittent claudication .", "sentence_id": 1}
+{"abstract_id": "25095886", "label": "results", "text": "After clinical and duplex ultrasound assessment , unselected patients with intermittent claudication requesting treatment for claudication were randomly assigned to invasive ( n = @ ) or noninvasive ( n = @ ) treatment groups .", "sentence_id": 2}
+{"abstract_id": "25095886", "label": "results", "text": "Primary end point was health-related quality of life after @ year , assessed with Medical Outcomes Study Short Form @ version @ and Vascular Quality of Life Questionnaire , and secondary end points included walking distances on a graded treadmill .", "sentence_id": 3}
+{"abstract_id": "25095886", "label": "results", "text": "The Medical Outcomes Study Short Form @ version @ physical component summary ( P < @ ) and @ Medical Outcomes Study Short Form @ version @ physical subscales improved significantly more in the invasive versus the noninvasive treatment group .", "sentence_id": 4}
+{"abstract_id": "25095886", "label": "results", "text": "Overall , Vascular Quality of Life Questionnaire score ( P < @ ) and @ of @ domain scores improved significantly more in the invasive versus the noninvasive treatment group .", "sentence_id": 5}
+{"abstract_id": "25095886", "label": "results", "text": "Intermittent claudication distance improved significantly in the invasive ( +@ m ) versus the noninvasive ( +@ m ) group ( P = @ ) , whereas the change in maximum walking distance was not significantly different between groups .", "sentence_id": 6}
+{"abstract_id": "25095886", "label": "conclusions", "text": "An invasive treatment strategy improves health-related quality of life and intermittent claudication distance after @ year in patients with stable lifestyle-limiting claudication receiving current medical management .", "sentence_id": 7}
+{"abstract_id": "25095886", "label": "conclusions", "text": "Long-term follow-up data and health-economic assessments are warranted to further establish the role for revascularization in intermittent claudication .", "sentence_id": 8}
+{"abstract_id": "25863654", "label": "background", "text": "Macrosomic fetuses are at increased risk of shoulder dystocia .", "sentence_id": 0}
+{"abstract_id": "25863654", "label": "background", "text": "We aimed to compare induction of labour with expectant management for large-for-date fetuses for prevention of shoulder dystocia and other neonatal and maternal morbidity associated with macrosomia .", "sentence_id": 1}
+{"abstract_id": "25863654", "label": "methods", "text": "We did this pragmatic , randomised controlled trial between Oct @ , @ , and Jan @ , @ , in @ tertiary-care centres in France , Switzerland , and Belgium .", "sentence_id": 2}
+{"abstract_id": "25863654", "label": "methods", "text": "Women with singleton fetuses whose estimated weight exceeded the @th percentile , were randomly assigned ( @:@ ) , via computer-generated permuted-block randomisation ( block size of four to eight ) to receive induction of labour within @ days between @ ( +@ ) weeks and @ ( +@ ) weeks of gestation , or expectant management .", "sentence_id": 3}
+{"abstract_id": "25863654", "label": "methods", "text": "Randomisation was stratified by centre .", "sentence_id": 4}
+{"abstract_id": "25863654", "label": "methods", "text": "Participants and caregivers were not masked to group assignment .", "sentence_id": 5}
+{"abstract_id": "25863654", "label": "methods", "text": "Our primary outcome was a composite of clinically significant shoulder dystocia , fracture of the clavicle , brachial plexus injury , intracranial haemorrhage , or death .", "sentence_id": 6}
+{"abstract_id": "25863654", "label": "methods", "text": "We did analyses by intention to treat .", "sentence_id": 7}
+{"abstract_id": "25863654", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "25863654", "label": "results", "text": "We randomly assigned @ women to the induction group and @ women to the expectant management group , of whom @ women and @ women , respectively , were included in the final analysis .", "sentence_id": 9}
+{"abstract_id": "25863654", "label": "results", "text": "Mean birthweight was @ g ( SD @ ) in the induction group and @ g ( @ ) in the expectant group .", "sentence_id": 10}
+{"abstract_id": "25863654", "label": "results", "text": "Induction of labour significantly reduced the risk of shoulder dystocia or associated morbidity ( n = @ ) compared with expectant management ( n = @ ; relative risk -LSB- RR -RSB- @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25863654", "label": "results", "text": "We recorded no brachial plexus injuries , intracranial haemorrhages , or perinatal deaths .", "sentence_id": 12}
+{"abstract_id": "25863654", "label": "results", "text": "The likelihood of spontaneous vaginal delivery was higher in women in the induction group than in those in the expectant management group ( RR @ , @ % CI @-@ ) .", "sentence_id": 13}
+{"abstract_id": "25863654", "label": "results", "text": "Caesarean delivery and neonatal morbidity did not differ significantly between the groups .", "sentence_id": 14}
+{"abstract_id": "25863654", "label": "conclusions", "text": "Induction of labour for suspected large-for-date fetuses is associated with a reduced risk of shoulder dystocia and associated morbidity compared with expectant management .", "sentence_id": 15}
+{"abstract_id": "25863654", "label": "conclusions", "text": "Induction of labour does not increase the risk of caesarean delivery and improves the likelihood of spontaneous vaginal delivery .", "sentence_id": 16}
+{"abstract_id": "25863654", "label": "conclusions", "text": "These benefits should be balanced with the effects of early-term induction of labour .", "sentence_id": 17}
+{"abstract_id": "24656636", "label": "background", "text": "Elevated concentrations of doxorubicin are found in eccrine sweat glands of the palms and soles .", "sentence_id": 0}
+{"abstract_id": "24656636", "label": "background", "text": "We therefore evaluated an antiperspirant as preventive treatment for palmar-plantar erythrodysesthesia ( hand-foot syndrome ) in patients with metastatic breast cancer treated with pegylated liposomal doxorubicin .", "sentence_id": 1}
+{"abstract_id": "24656636", "label": "methods", "text": "An antiperspirant containing aluminum chlorohydrate or placebo cream was applied to the left or right hand and foot in a double-blinded manner ( intra-patient randomization ) .", "sentence_id": 2}
+{"abstract_id": "24656636", "label": "methods", "text": "The primary endpoint was the rate of grade @ or @ palmar-plantar erythrodysesthesia .", "sentence_id": 3}
+{"abstract_id": "24656636", "label": "methods", "text": "A secondary endpoint was the patient-reported symptom burden ( tingling , numbness , pain , or skin problems ) .", "sentence_id": 4}
+{"abstract_id": "24656636", "label": "methods", "text": "Using McNemar 's matched pairs design , @ patients were needed to detect a @ % difference between the treatment and placebo sides with a significance level of @ % and power of @ % .", "sentence_id": 5}
+{"abstract_id": "24656636", "label": "results", "text": "Grade @ or @ PPE occurred in @ ( @ % ) of @ evaluable patients ; in six patients adverse effects occurred on the placebo side but not on the treatment side , whereas one patient developed palmar-plantar erythrodysesthesia on the treatment side only ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24656636", "label": "results", "text": "Four patients developed grade @ or @ palmar-plantar erythrodysesthesia on their foot on the placebo side but not on the treatment side ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24656636", "label": "results", "text": "In the cohort with grade @ or @ palmar-plantar erythrodysesthesia there was a trend towards fewer dermatologic symptomatologies with the active treatment ( P = @ ) , and no difference for other adverse events .", "sentence_id": 8}
+{"abstract_id": "24656636", "label": "conclusions", "text": "Using topical aluminum chlorohydrate as an antiperspirant appears to reduce the incidence of grade @ or @ palmar-plantar erythrodysesthesia following pegylated liposomal doxorubicin chemotherapy for metastatic breast cancer .", "sentence_id": 9}
+{"abstract_id": "24941177", "label": "background", "text": "Methotrexate is the most frequently used first-line antirheumatic drug .", "sentence_id": 0}
+{"abstract_id": "24941177", "label": "background", "text": "We report the findings of a phase @ study of monotherapy with tofacitinib , an oral Janus kinase inhibitor , as compared with methotrexate monotherapy in patients with rheumatoid arthritis who had not previously received methotrexate or therapeutic doses of methotrexate .", "sentence_id": 1}
+{"abstract_id": "24941177", "label": "methods", "text": "We randomly assigned @ patients to receive @ mg or @ mg of tofacitinib twice daily or methotrexate at a dose that was incrementally increased to @ mg per week over @ weeks ; @ patients received a study drug .", "sentence_id": 2}
+{"abstract_id": "24941177", "label": "methods", "text": "The coprimary end points at month @ were the mean change from baseline in the van der Heijde modified total Sharp score ( which ranges from @ to @ , with higher scores indicating greater structural joint damage ) and the proportion of patients with an American College of Rheumatology ( ACR ) @ response ( @ % reduction in the number of both tender and swollen joints and @ % improvement in three of five other criteria : the patient 's assessment of pain , level of disability , C-reactive protein level or erythrocyte sedimentation rate , global assessment of disease by the patient , and global assessment of disease by the physician ) .", "sentence_id": 3}
+{"abstract_id": "24941177", "label": "results", "text": "Mean changes in the modified total Sharp score from baseline to month @ were significantly smaller in the tofacitinib groups than in the methotrexate group , but changes were modest in all three groups ( @ points in the @-mg tofacitinib group and < @ point in the @-mg tofacitinib group , as compared with @ points in the methotrexate group -LSB- P < @ for both comparisons -RSB- ) .", "sentence_id": 4}
+{"abstract_id": "24941177", "label": "results", "text": "Among the patients receiving tofacitinib , @ % in the @-mg group and @ % in the @-mg group had an ACR @ response at month @ , as compared with @ % of patients in the methotrexate group ( P < @ for both comparisons ) .", "sentence_id": 5}
+{"abstract_id": "24941177", "label": "results", "text": "Herpes zoster developed in @ of @ patients who received tofacitinib ( @ % ) and in @ of @ patients who received methotrexate ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "24941177", "label": "results", "text": "Confirmed cases of cancer ( including three cases of lymphoma ) developed in @ patients who received tofacitinib and in @ patient who received methotrexate .", "sentence_id": 7}
+{"abstract_id": "24941177", "label": "results", "text": "Tofacitinib was associated with increases in creatinine levels and in low-density and high-density lipoprotein cholesterol levels .", "sentence_id": 8}
+{"abstract_id": "24941177", "label": "conclusions", "text": "In patients who had not previously received methotrexate or therapeutic doses of methotrexate , tofacitinib monotherapy was superior to methotrexate in reducing signs and symptoms of rheumatoid arthritis and inhibiting the progression of structural joint damage .", "sentence_id": 9}
+{"abstract_id": "24941177", "label": "conclusions", "text": "The benefits of tofacitinib need to be considered in the context of the risks of adverse events .", "sentence_id": 10}
+{"abstract_id": "24941177", "label": "conclusions", "text": "( Funded by Pfizer ; ORAL Start ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "25257064", "label": "background", "text": "Depression is common and the efficacy of antidepressants is suboptimal .", "sentence_id": 0}
+{"abstract_id": "25257064", "label": "background", "text": "High plasma homocysteine has been consistently associated with depression , and treatment with certain B vitamins demonstrably reduces its concentration .", "sentence_id": 1}
+{"abstract_id": "25257064", "label": "objective", "text": "To determine whether vitamins B@ , B@ and folic acid enhance response to antidepressant treatment over @ weeks .", "sentence_id": 2}
+{"abstract_id": "25257064", "label": "methods", "text": "Randomised , double-blind , placebo-controlled trial of citalopram ( @-@ g ) together with @ mg of vitamin B@ , @ mg of folic acid and @ mg of vitamin B@ for @ weeks ( Australian and New Zealand Clinical Trials Registry : @ ) .", "sentence_id": 3}
+{"abstract_id": "25257064", "label": "methods", "text": "Participants were community-dwelling adults aged @ years or over with DSM-IV-TR major depression .", "sentence_id": 4}
+{"abstract_id": "25257064", "label": "methods", "text": "We measured severity of symptoms with the Montgomery-sberg Depression Rating Scale ( MADRS ) .", "sentence_id": 5}
+{"abstract_id": "25257064", "label": "methods", "text": "The primary outcome was remission of the depressive episode after @ , @ and @ weeks .", "sentence_id": 6}
+{"abstract_id": "25257064", "label": "methods", "text": "Secondary outcomes included reduction of MADRS scores over time and relapse of major depression after recovery by week @ .", "sentence_id": 7}
+{"abstract_id": "25257064", "label": "methods", "text": "Results In total , @ people were randomised ( @ placebo , @ vitamins ) .", "sentence_id": 8}
+{"abstract_id": "25257064", "label": "methods", "text": "Remission of symptoms was achieved by @ and @ % of participants treated with placebo and vitamins by week @ ( P = @ ) , by @ and @ % at week @ and @ and @ % at week @ ( effect of intervention over @ weeks : odds ratio ( OR ) = @ , @ % CI @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25257064", "label": "methods", "text": "Group differences in MADRS scores over time were not significant ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25257064", "label": "methods", "text": "The risk of subsequent relapse among those who had achieved remission of symptoms at week @ was lower in the vitamins than placebo group ( OR = @ , @ % CI @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "25257064", "label": "conclusions", "text": "B vitamins did not increase the @-week efficacy of antidepressant treatment , but enhanced and sustained antidepressant response over @ year .", "sentence_id": 12}
+{"abstract_id": "25257064", "label": "conclusions", "text": "Replication of these findings would mandate that treatment guidelines adopt the adjunctive use of B vitamins as a safe and inexpensive strategy to manage major depression in middle-aged and older adults .", "sentence_id": 13}
+{"abstract_id": "25627340", "label": "objective", "text": "The Veterans Administration Cooperative Studies Program # @ , a multicenter study that randomized Parkinson 's disease ( PD ) patients to either subthalamic nucleus ( STN ) or globus pallidus internus ( GPi ) deep brain stimulation ( DBS ) , found that stimulation at either target provided similar overall motoric benefits .", "sentence_id": 0}
+{"abstract_id": "25627340", "label": "objective", "text": "We conducted an additional analysis of this data set to evaluate whether PD motor subtypes responded differently to the @ stimulation targets .", "sentence_id": 1}
+{"abstract_id": "25627340", "label": "methods", "text": "We classified @ subjects by motor subtype : tremor dominant ( TD ) , intermediate ( I ) , or postural instability gait difficulty ( PIGD ) , based on pre-DBS baseline Unified Parkinson 's Disease Rating Scale ( UPDRS ) scores off-medication .", "sentence_id": 2}
+{"abstract_id": "25627340", "label": "methods", "text": "The primary outcome was change in UPDRS part III ( UPDRS-III ) off-medication scores from baseline to @ months post-DBS , compared among subjects with particular PD motor subtypes and by DBS target ( STN vs GPi ) .", "sentence_id": 3}
+{"abstract_id": "25627340", "label": "methods", "text": "Changes in tremor , rigidity , akinesia , and gait scores were also assessed using the UPDRS .", "sentence_id": 4}
+{"abstract_id": "25627340", "label": "results", "text": "TD patients had greater mean overall motor improvement , measured by UPDRS-III , after GPi DBS , compared to STN DBS ( @ vs @ , p = @ ) , with improvement in gait accounting for this difference .", "sentence_id": 5}
+{"abstract_id": "25627340", "label": "results", "text": "Regardless of stimulation target , PIGD subjects had lower mean overall improvement in UPDRS-III scores compared with I or TD subjects ( @ vs @ vs @ , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25627340", "label": "conclusions", "text": "Our results suggest that responsiveness to both GPi and STN DBS is similar among different PD motor subtypes , although the TD motor subtype may have a greater response to GPi DBS with respect to gait .", "sentence_id": 7}
+{"abstract_id": "25627340", "label": "conclusions", "text": "PIGD patients obtained less overall benefit from stimulation .", "sentence_id": 8}
+{"abstract_id": "25465711", "label": "objective", "text": "To compare the six-month outcome of three different ultrasound-guided treatments for de Quervain 's disease ( DQD ) .", "sentence_id": 0}
+{"abstract_id": "25465711", "label": "methods", "text": "We prospectively treated @ consecutive patients ( @ females , @ males , mean age standard deviation = @ years ) with DQD .", "sentence_id": 1}
+{"abstract_id": "25465711", "label": "methods", "text": "Patients ' features ( hand dominance , intraretinaculum septum , accessory tendons ) were recorded .", "sentence_id": 2}
+{"abstract_id": "25465711", "label": "methods", "text": "Visual analogue scale ( VAS ) , reduced disability ( quickDASH ) score , and retinaculum thickness were evaluated at baseline and after one ( excluding retinaculum thickness ) , three , and six months .", "sentence_id": 3}
+{"abstract_id": "25465711", "label": "methods", "text": "Patients were randomized into three groups of @ patients each treated under ultrasound guidance : Group A ( @ ml methylprednisolone acetate ; mean baseline thickness = @ mm ; mean baseline VAS = @ ; mean baseline quickDASH = @ ) ; Group B ( @ ml methylprednisolone acetate +@ - day delayed @ ml saline @ % ; @ ; @ ; @ ) ; Group C ( @ ml methylprednisolone acetate +@ - day delayed @ ml low molecular weight hyaluronic acid ; @ ; @ ; @ ) .", "sentence_id": 4}
+{"abstract_id": "25465711", "label": "results", "text": "After one month results were : Group A mean VAS = @ ; mean quickDASH = @ ; Group B @ ; @ ; Group C @ ; @ .", "sentence_id": 5}
+{"abstract_id": "25465711", "label": "results", "text": "After three months results were : Group A retinaculum thickness = @ mm ; @ ; @ ) ; Group B @ mm ; @ ; @ ; Group C @ mm ; @ ; @ .", "sentence_id": 6}
+{"abstract_id": "25465711", "label": "results", "text": "After six months results were : Group A @ mm ; @ ; @ ; Group B @ mm ; @ ; @ ; Group C @ mm ; @ ; @ ( P < @ for all vs. baseline ) .", "sentence_id": 7}
+{"abstract_id": "25465711", "label": "results", "text": "Patients ' age , sex , hand dominance , presence of subcompartment dividing septum , and supernumerary tendons had no influence on outcome ( P @ ) .", "sentence_id": 8}
+{"abstract_id": "25465711", "label": "conclusions", "text": "Addition of hyaluronic acid to ultrasound-guided injections of steroids to treat DQD seems to improve the outcome and to reduce the recurrence rate .", "sentence_id": 9}
+{"abstract_id": "25465711", "label": "conclusions", "text": "Ultrasound guidance allows for safe injection procedures to treat de Quervains ' disease Steroid injections allow prompt recovery in de Quervain 's disease with short-term recurrence Addition of hyaluronic acid allows recurrence rate reduction compared to simple steroid injections .", "sentence_id": 10}
+{"abstract_id": "25354581", "label": "background", "text": "Older individuals often have a reduced immune response to influenza vaccination , which might be improved by administering a higher vaccine dose .", "sentence_id": 0}
+{"abstract_id": "25354581", "label": "background", "text": "We compared the immune response to two single doses of the AS@A-adjuvanted H@N@ pandemic vaccine ( @ g hemagglutinin of A/Vietnam/@ / @ ) with that of two double vaccine doses ( @ g hemagglutinin ) in adults aged @ years .", "sentence_id": 1}
+{"abstract_id": "25354581", "label": "background", "text": "Here we report the @-year persistence of the humoral and cellular immune response .", "sentence_id": 2}
+{"abstract_id": "25354581", "label": "methods", "text": "In this phase II , open-label study , healthy participants aged @ to @ years ( median @ years ) were randomised ( @:@:@:@ ) to receive two single doses of the AS@A-adjuvanted vaccine ( @xH@N@-AS ) or the non-adjuvanted vaccine ( @xH@N@ ) , or two double doses of the AS@A-adjuvanted vaccine ( @xH@N@-AS ) or the non-adjuvanted vaccine ( @xH@N@ ) , @ days apart .", "sentence_id": 3}
+{"abstract_id": "25354581", "label": "methods", "text": "Serum haemagglutination inhibition antibodies and cellular immune responses against A/Vietnam/@ / @ were measured in all groups at months @ and @ ; neutralising antibodies were assessed in a subset of the adjuvanted groups .", "sentence_id": 4}
+{"abstract_id": "25354581", "label": "methods", "text": "Serious adverse events and adverse events of specific interest were recorded .", "sentence_id": 5}
+{"abstract_id": "25354581", "label": "results", "text": "At month @ , haemagglutination inhibition antibody seroprotection rates were @ % ( @ % CI @ % to @ % ) for @xH@N@-AS , @ % ( @ % CI @ % to @ % ) for @xH@N@-AS , @ % ( @ % CI @ % to @ % ) for @xH@N@ , and @ % ( @ % CI @ % to @ % ) for @xH@N@ .", "sentence_id": 6}
+{"abstract_id": "25354581", "label": "results", "text": "Haemagglutination inhibition antibody geometric mean titres were @ ( @ % CI @ to @ ) for @xH@N@-AS , @ ( @ % CI @ to @ ) for @xH@N@-AS , @ ( @ % CI @ to @ ) for @xH@N@ and @ ( @ % CI @ to @ ) for @xH@N@ .", "sentence_id": 7}
+{"abstract_id": "25354581", "label": "results", "text": "The median frequency of antigen-specific CD@ + T cells per @ T cells ( @th quartile ; @th quartile ) was @ ( @ ; @ ) for @xH@N@-AS , @ ( @ ; @ ) for @xH@N@-AS , @ ( @ ; @ ) for @x-H@N@ and @ ( @ ; @ ) for @xH@N@ .", "sentence_id": 8}
+{"abstract_id": "25354581", "label": "results", "text": "Neutralising antibody geometric mean titres were @ ( @ % CI @ to @ ) in the @xH@N@-AS group and @ ( @ % CI @ to @ ) in the @xH@N@-AS group .", "sentence_id": 9}
+{"abstract_id": "25354581", "label": "conclusions", "text": "Antibody levels declined substantially in all groups .", "sentence_id": 10}
+{"abstract_id": "25354581", "label": "conclusions", "text": "Seroprotection rates , geometric mean titres for haemagglutination inhibition antibodies , and CD@ + T-cell responses tended to be higher in the AS@A-adjuvanted groups .", "sentence_id": 11}
+{"abstract_id": "25354581", "label": "conclusions", "text": "There was no clear benefit , in terms of long-term persistence of the immune response , of doubling the dose of the adjuvanted vaccine .", "sentence_id": 12}
+{"abstract_id": "25354581", "label": "conclusions", "text": "No safety concern was observed up to @ months post-primary vaccination .", "sentence_id": 13}
+{"abstract_id": "24824051", "label": "background", "text": "School-based mass treatment with praziquantel is the cornerstone for schistosomiasis control in school-aged children .", "sentence_id": 0}
+{"abstract_id": "24824051", "label": "background", "text": "However , uptake of treatment among school-age children in Uganda is low in some areas .", "sentence_id": 1}
+{"abstract_id": "24824051", "label": "background", "text": "The objective of the study was to examine the effectiveness of a pre-treatment snack on uptake of mass treatment .", "sentence_id": 2}
+{"abstract_id": "24824051", "label": "results", "text": "In a cluster randomized trial carried out in Jinja district , Uganda , @ primary schools were randomized into two groups ; one received education messages for schistosomiasis prevention for two months prior to mass treatment , while the other , in addition to the education messages , received a pre-treatment snack shortly before mass treatment .", "sentence_id": 3}
+{"abstract_id": "24824051", "label": "results", "text": "Four weeks after mass treatment , uptake of praziquantel was assessed among a random sample of @ children in the snack schools and @ children in the non-snack schools as the primary outcome .", "sentence_id": 4}
+{"abstract_id": "24824051", "label": "results", "text": "The occurrence of side effects and the prevalence and mean intensity of Schistosoma mansoni infection were determined as the secondary outcomes .", "sentence_id": 5}
+{"abstract_id": "24824051", "label": "results", "text": "Uptake of praziquantel was higher in the snack schools , @ % ( @ % CI @ % -@ % ) , compared to that in the non-snack schools , @ % ( @ % CI @ % -@ % ) ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24824051", "label": "results", "text": "The occurrence of side effects was lower in the snack schools , @ % ( @ % CI @ % -@ % ) , compared to that in the non-snack schools , @ % ( @ % CI @ % -@ % ) ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24824051", "label": "results", "text": "Prevalence and mean intensity of S. mansoni infection was lower in the snack schools , @ % ( @ % CI @ % -@ % ) and @ eggs per gram of stool ( epg ) ( @ % CI @-@ @ ) , compared to that in the non-snack schools , @ % ( @ % CI @ % -@ % ) ( p = @ ) and @ epg ( @ % CI @-@ @ ) ( p = @ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "24824051", "label": "conclusions", "text": "Our results suggest that provision of a pre-treatment snack combined with education messages achieves a higher uptake compared to the education messages alone .", "sentence_id": 9}
+{"abstract_id": "24824051", "label": "conclusions", "text": "The use a pre-treatment snack was associated with reduced side effects as well as decreased prevalence and intensity of S. mansoni infection .", "sentence_id": 10}
+{"abstract_id": "25440798", "label": "background", "text": "The tradeoff between stent thrombosis ( ST ) and major bleeding ( MB ) of @ - versus @-month dual antiplatelet therapy ( DAPT ) after coronary stent implantation has not been clearly defined .", "sentence_id": 0}
+{"abstract_id": "25440798", "label": "methods", "text": "Definite/probable ST and MB ( TIMI major and Bleeding Academic Research Consortium ( BARC ) @ ) were compared in @ subsequent trials with similar inclusion criteria but different DAPT duration , that is , BASKET ( @ months ; n = @ ) and BASKET-PROVE ( @ months ; n = @,@ ) , between months @ to @ ( DAPT in both trials ) , @ to @ ( DAPT in BASKET-PROVE only ) , and @ to @ ( aspirin in both trials ) using propensity score-adjusted , time-stratified Cox proportional hazard models .", "sentence_id": 1}
+{"abstract_id": "25440798", "label": "results", "text": "Overall , event rates were low with fewer ST but similar MB in prolonged DAPT .", "sentence_id": 2}
+{"abstract_id": "25440798", "label": "results", "text": "Analysis of the @ periods showed a uniform pattern for ST ( interaction DAPT/period ; P = @ ) but an inconsistent pattern for MB ( interaction DAPT/period ; P < @ for TIMI major and P = @ for BARC @ ) , with more MB occurring during months @ to @ with prolonged DAPT .", "sentence_id": 3}
+{"abstract_id": "25440798", "label": "results", "text": "Considering observed case fatality rates of @ % with ST and @ % with MB , the extrapolated prevention of @ ST deaths and the excess of @ MB deaths resulted in an expected benefit of @ survivors/@ ,@ patients treated over @ years with prolonged DAPT .", "sentence_id": 4}
+{"abstract_id": "25440798", "label": "conclusions", "text": "Despite overall low event rates , prolonged DAPT was associated with more MB during months @ to @ according to the interaction DAPT/period .", "sentence_id": 5}
+{"abstract_id": "25440798", "label": "conclusions", "text": "Given the higher observed case fatality rates of ST versus MB , @ - versus @-month DAPT was associated with an extrapolated reduction in mortality .", "sentence_id": 6}
+{"abstract_id": "25440798", "label": "conclusions", "text": "Effective treatment periods and case fatality rates seem important in the analysis of different DAPT durations , specifically with regard to ongoing trials .", "sentence_id": 7}
+{"abstract_id": "24581465", "label": "objective", "text": "To identify risk factors for port infections within @ days of placement .", "sentence_id": 0}
+{"abstract_id": "24581465", "label": "methods", "text": "A retrospective chart review of port placements from @-@ was conducted .", "sentence_id": 1}
+{"abstract_id": "24581465", "label": "methods", "text": "Patients who had port removals secondary to infection within the first @ days of placement were included .", "sentence_id": 2}
+{"abstract_id": "24581465", "label": "methods", "text": "This group of patients was compared with a control group of patients with ports with no evidence of infection .", "sentence_id": 3}
+{"abstract_id": "24581465", "label": "methods", "text": "For every one patient with a port infection , two control subjects were chosen of the same gender and new port placement during the same month as the corresponding patient with an infected port .", "sentence_id": 4}
+{"abstract_id": "24581465", "label": "results", "text": "From @-@ , @,@ ports were placed .", "sentence_id": 5}
+{"abstract_id": "24581465", "label": "results", "text": "Of the @,@ patients , @ ( @ % ) were found to have a port infection within @ days of placement .", "sentence_id": 6}
+{"abstract_id": "24581465", "label": "results", "text": "Compared with the control group , the early infection group had a higher prevalence of leukopenia ( @ % vs @ % , P = @ ) and thrombocytopenia ( @ % vs @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24581465", "label": "results", "text": "There was also a higher prevalence of an inpatient hospital stay during port placement and high international normalized ratio in the early infection group .", "sentence_id": 8}
+{"abstract_id": "24581465", "label": "conclusions", "text": "Low preoperative white blood cell and platelet counts were risk factors for early infection .", "sentence_id": 9}
+{"abstract_id": "24581465", "label": "conclusions", "text": "Abnormal coagulation profiles and inpatient access of ports after placement could be additional risk factors .", "sentence_id": 10}
+{"abstract_id": "24762371", "label": "objective", "text": "Quality of life ( QOL ) can be considered as a quality indicator of health care systems and nurses can play an important role to improve QOL in patients with congestive heart failure ( CHF ) .", "sentence_id": 0}
+{"abstract_id": "24762371", "label": "objective", "text": "The aim of this study was to determine the effects of education provided by nurses on the QOL in patients with CHF in home-visit care compared to usual care .", "sentence_id": 1}
+{"abstract_id": "24762371", "label": "methods", "text": "In a single-blind randomized controlled trial conducted from September @ to June @ , @ patients with CHF were randomly assigned into two groups .", "sentence_id": 2}
+{"abstract_id": "24762371", "label": "methods", "text": "While patients in group I were received usual education at the time of hospital discharge , patients in Group II , in addition to usual education , were received special education regards to their illness by nurses who visited patients in their homes .", "sentence_id": 3}
+{"abstract_id": "24762371", "label": "methods", "text": "The @-item short-form ( SF-@ ) questionnaire was used to evaluate the patient 's QOL at the time of discharge and also six months after hospital discharge .", "sentence_id": 4}
+{"abstract_id": "24762371", "label": "results", "text": "At the time of hospital discharge , mean score of all @ sub-score of SF-@ questionnaire was @ in patients of group II and @ in patients of group I , respectively ( P > @ ) .", "sentence_id": 5}
+{"abstract_id": "24762371", "label": "results", "text": "QOL was decreased in group I and increased in group II compared to the time of hospital discharge .", "sentence_id": 6}
+{"abstract_id": "24762371", "label": "results", "text": "After six months , mean score of QOL was higher in group II than in group I.", "sentence_id": 7}
+{"abstract_id": "24762371", "label": "conclusions", "text": "QOL of patients with CHF were decreased after hospital discharge .", "sentence_id": 8}
+{"abstract_id": "24762371", "label": "conclusions", "text": "Education provided by nurses in home-visit care could improve the QOL in patients with CHF , based on the findings of this study .", "sentence_id": 9}
+{"abstract_id": "24248037", "label": "background", "text": "Short message service ( SMS ) has been suggested as an effective method to improve adherence to medical therapy in some chronic diseases .", "sentence_id": 0}
+{"abstract_id": "24248037", "label": "background", "text": "However , data on the effects of SMS interventions to allergic rhinitis ( AR ) treatment is limited at present .", "sentence_id": 1}
+{"abstract_id": "24248037", "label": "background", "text": "We aimed to assess whether a daily SMS reminder could improve AR patients ' adherence to medication and treatment outcomes .", "sentence_id": 2}
+{"abstract_id": "24248037", "label": "methods", "text": "Fifty outpatients with AR were randomized to either receive ( SMS group ) or not ( control group ) a daily SMS reminder on their cell phone to take intranasal corticosteroid treatment for @ days .", "sentence_id": 3}
+{"abstract_id": "24248037", "label": "methods", "text": "The primary study outcomes were self-reported adherence to medication , clinic attendance rate , and severity of AR symptoms using a visual analogue scale ( VAS ) .", "sentence_id": 4}
+{"abstract_id": "24248037", "label": "methods", "text": "Secondary outcomes were changes in nasal patency ( minimum cross-sectional area , nasal cavity volume , and nasal airway resistance ) and exhaled nasal nitric oxide levels .", "sentence_id": 5}
+{"abstract_id": "24248037", "label": "results", "text": "Self-reported adherence to medication in the SMS group ( @/@ , @ % ) , was significantly higher than in the control group ( @/@ , @ % , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24248037", "label": "results", "text": "Similarly , the clinic attendance rate in the SMS group ( @ % ) was significantly higher than in the control group ( @ % , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24248037", "label": "results", "text": "Although the VAS score improved significantly from baseline in both study groups , the improvement in the SMS group was significantly greater than in the control group ( @ @ vs. @ @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24248037", "label": "results", "text": "No significant differences were observed between the two groups for the secondary outcomes .", "sentence_id": 9}
+{"abstract_id": "24248037", "label": "conclusions", "text": "A daily SMS reminder may be an effective intervention to improve adherence to medication and treatment outcomes in AR patients .", "sentence_id": 10}
+{"abstract_id": "26382998", "label": "background", "text": "The American Academy of Pediatrics recommends a permissive hypoxaemic target for an oxygen saturation of @ % for children with bronchiolitis , which is consistent with the WHO recommendations for targets in children with lower respiratory tract infections .", "sentence_id": 0}
+{"abstract_id": "26382998", "label": "background", "text": "No evidence exists to support this threshold .", "sentence_id": 1}
+{"abstract_id": "26382998", "label": "background", "text": "We aimed to assess whether the @ % or higher target for management of oxygen supplementation was equivalent to a normoxic @ % or higher target for infants admitted to hospital with viral bronchiolitis .", "sentence_id": 2}
+{"abstract_id": "26382998", "label": "methods", "text": "We did a parallel-group , randomised , controlled , equivalence trial of infants aged @ weeks to @ months of age with physician-diagnosed bronchiolitis newly admitted into eight paediatric hospital units in the UK ( the Bronchiolitis of Infancy Discharge Study -LSB- BIDS -RSB- ) .", "sentence_id": 3}
+{"abstract_id": "26382998", "label": "methods", "text": "A central computer randomly allocated ( @:@ ) infants , in varying length blocks of four and six and without stratification , to be clipped to standard oximeters ( patients treated with oxygen if pulse oxygen saturation -LSB- SpO@ -RSB- < @ % ) or modified oximeters ( displayed a measured value of @ % as @ % , therefore oxygen not given until SpO@ < @ % ) .", "sentence_id": 4}
+{"abstract_id": "26382998", "label": "methods", "text": "All parents , clinical staff , and outcome assessors were masked to allocation .", "sentence_id": 5}
+{"abstract_id": "26382998", "label": "methods", "text": "The primary outcome was time to resolution of cough ( prespecified equivalence limits of plus or minus @ days ) in the intention-to-treat population .", "sentence_id": 6}
+{"abstract_id": "26382998", "label": "methods", "text": "This trial is registered with ISRCTN , number ISRCTN@ .", "sentence_id": 7}
+{"abstract_id": "26382998", "label": "results", "text": "Between Oct @ , and March @ , @ , and Oct @ , and March @ , @ , we randomly assigned @ infants to standard oximeters and @ infants to modified oximeters .", "sentence_id": 8}
+{"abstract_id": "26382998", "label": "results", "text": "Cough resolved by @ days ( median ) in both groups ( @ % CI for difference -@ to @ ) and so oxygen thresholds were equivalent .", "sentence_id": 9}
+{"abstract_id": "26382998", "label": "results", "text": "We recorded @ serious adverse events in @ infants in the standard care group and @ serious adverse events in @ infants in the modified care group .", "sentence_id": 10}
+{"abstract_id": "26382998", "label": "results", "text": "In the standard care group , eight infants transferred to a high-dependency unit , @ were readmitted , and one had a prolonged hospital stay .", "sentence_id": 11}
+{"abstract_id": "26382998", "label": "results", "text": "In the modified care group , @ infants were transferred to a high-dependency unit and @ were readmitted to hospital .", "sentence_id": 12}
+{"abstract_id": "26382998", "label": "results", "text": "Recorded adverse events did not differ significantly .", "sentence_id": 13}
+{"abstract_id": "26382998", "label": "conclusions", "text": "Management of infants with bronchiolitis to an oxygen saturation target of @ % or higher is as safe and clinically effective as one of @ % or higher .", "sentence_id": 14}
+{"abstract_id": "26382998", "label": "conclusions", "text": "Future research should assess the benefits and risks of different oxygen saturation targets in acute respiratory infection in older children , particularly in developing nations where resources are scarce .", "sentence_id": 15}
+{"abstract_id": "24346989", "label": "objective", "text": "Chronic periodontitis , a destructive inflammatory disorder of the supporting structures of the teeth , is prevalent in patients with diabetes .", "sentence_id": 0}
+{"abstract_id": "24346989", "label": "objective", "text": "Limited evidence suggests that periodontal therapy may improve glycemic control .", "sentence_id": 1}
+{"abstract_id": "24346989", "label": "objective", "text": "To determine if nonsurgical periodontal treatment reduces levels of glycated hemoglobin ( HbA@c ) in persons with type @ diabetes and moderate to advanced chronic periodontitis .", "sentence_id": 2}
+{"abstract_id": "24346989", "label": "methods", "text": "The Diabetes and Periodontal Therapy Trial ( DPTT ) , a @-month , single-masked , multicenter , randomized clinical trial .", "sentence_id": 3}
+{"abstract_id": "24346989", "label": "methods", "text": "Participants had type @ diabetes , were taking stable doses of medications , had HbA@c levels between @ % and less than @ % , and untreated chronic periodontitis .", "sentence_id": 4}
+{"abstract_id": "24346989", "label": "methods", "text": "Five hundred fourteen participants were enrolled between November @ and March @ from diabetes and dental clinics and communities affiliated with @ academic medical centers .", "sentence_id": 5}
+{"abstract_id": "24346989", "label": "methods", "text": "The treatment group ( n = @ ) received scaling and root planing plus chlorhexidine oral rinse at baseline and supportive periodontal therapy at @ and @ months .", "sentence_id": 6}
+{"abstract_id": "24346989", "label": "methods", "text": "The control group ( n = @ ) received no treatment for @ months .", "sentence_id": 7}
+{"abstract_id": "24346989", "label": "methods", "text": "Difference in change in HbA@c level from baseline between groups at @ months .", "sentence_id": 8}
+{"abstract_id": "24346989", "label": "methods", "text": "Secondary outcomes included changes in probing pocket depths , clinical attachment loss , bleeding on probing , gingival index , fasting glucose level , and Homeostasis Model Assessment ( HOMA@ ) score .", "sentence_id": 9}
+{"abstract_id": "24346989", "label": "results", "text": "Enrollment was stopped early because of futility .", "sentence_id": 10}
+{"abstract_id": "24346989", "label": "results", "text": "At @ months , mean HbA@c levels in the periodontal therapy group increased @ % ( SD , @ ) , compared with @ % ( SD , @ ) in the control group , with no significant difference between groups based on a linear regression model adjusting for clinical site ( mean difference , -@ % -LSB- @ % CI , -@ % to @ % -RSB- ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24346989", "label": "results", "text": "Periodontal measures improved in the treatment group compared with the control group at @ months , with adjusted between-group differences of @ mm ( @ % CI , @ to @ ) for probing depth , @ mm ( @ % CI , @ to @ ) for clinical attachment loss , @ % ( @ % CI , @ % to @ % ) for bleeding on probing , and @ ( @ % CI , @ to @ ) for gingival index ( P < @ for all ) .", "sentence_id": 12}
+{"abstract_id": "24346989", "label": "conclusions", "text": "Nonsurgical periodontal therapy did not improve glycemic control in patients with type @ diabetes and moderate to advanced chronic periodontitis .", "sentence_id": 13}
+{"abstract_id": "24346989", "label": "conclusions", "text": "These findings do not support the use of nonsurgical periodontal treatment in patients with diabetes for the purpose of lowering levels of HbA@c .", "sentence_id": 14}
+{"abstract_id": "24280465", "label": "objective", "text": "To evaluate the sustaining effects of Tai chi Qigong in improving the physiological health for COPD patients at sixth month .", "sentence_id": 0}
+{"abstract_id": "24280465", "label": "methods", "text": "A randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24280465", "label": "methods", "text": "Subjects were in three randomly assigned groups : Tai chi Qigong group , exercise group , and control group .", "sentence_id": 2}
+{"abstract_id": "24280465", "label": "methods", "text": "The @ subjects were recruited from five general outpatient clinics .", "sentence_id": 3}
+{"abstract_id": "24280465", "label": "methods", "text": "Tai chi Qigong group completed a @-month Tai chi Qigong program .", "sentence_id": 4}
+{"abstract_id": "24280465", "label": "methods", "text": "Exercise group practiced breathing and walking as an exercise .", "sentence_id": 5}
+{"abstract_id": "24280465", "label": "methods", "text": "Control group received usual care .", "sentence_id": 6}
+{"abstract_id": "24280465", "label": "methods", "text": "Primary outcomes included six-minute walking distance and lung functions .", "sentence_id": 7}
+{"abstract_id": "24280465", "label": "methods", "text": "Secondary outcomes were dyspnea and fatigue levels , number of exacerbations and hospital admissions .", "sentence_id": 8}
+{"abstract_id": "24280465", "label": "results", "text": "Tai chi Qigong group showed a steady improvement in exercise capacity ( P < @ ) from baseline to the sixth month .", "sentence_id": 9}
+{"abstract_id": "24280465", "label": "results", "text": "The mean walking distance increased from @ to @ meters ( +@ % ) .", "sentence_id": 10}
+{"abstract_id": "24280465", "label": "results", "text": "No significant changes were noted in the other two groups .", "sentence_id": 11}
+{"abstract_id": "24280465", "label": "results", "text": "Tai chi Qigong group also showed improvement in lung functions ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24280465", "label": "results", "text": "Mean forced expiratory volume in @s increased from @ to @ l ( +@ % ) .", "sentence_id": 13}
+{"abstract_id": "24280465", "label": "results", "text": "No significant change was noted in the exercise group .", "sentence_id": 14}
+{"abstract_id": "24280465", "label": "results", "text": "Deterioration was found in the control group , with mean volume decreased from @ to @ l ( -@ % ) .", "sentence_id": 15}
+{"abstract_id": "24280465", "label": "results", "text": "Significant decreased in the number of exacerbations was observed in the Tai chi Qigong group .", "sentence_id": 16}
+{"abstract_id": "24280465", "label": "results", "text": "No changes in dyspnea and fatigue levels were noted among the three groups .", "sentence_id": 17}
+{"abstract_id": "24280465", "label": "conclusions", "text": "Tai chi Qigong has sustaining effects in improving the physiological health and is a useful and appropriate exercise for COPD patients .", "sentence_id": 18}
+{"abstract_id": "24754203", "label": "background", "text": "During maneuvering , fighter pilots experience loads of up to @-@ kg on their necks .", "sentence_id": 0}
+{"abstract_id": "24754203", "label": "background", "text": "Neck disorders are common and have been linked to impairment in muscle control .", "sentence_id": 1}
+{"abstract_id": "24754203", "label": "background", "text": "We conducted an intervention study introducing targeted training for @ wk that reduced neck pain .", "sentence_id": 2}
+{"abstract_id": "24754203", "label": "background", "text": "The current study reports the results of the secondary objective , which was to increase the understanding of possible mechanisms underlying such neck pain and its intervention-related relief .", "sentence_id": 3}
+{"abstract_id": "24754203", "label": "methods", "text": "In a parallel , single-blinded , randomized controlled study , @ F-@ pilots were evaluated at baseline and randomized to a control group ( CG ; N = @ ) or training group ( TG ; N = @ ) .", "sentence_id": 4}
+{"abstract_id": "24754203", "label": "methods", "text": "Postural control was tested in four different settings : Romberg with open and closed eyes , unilateral stance , and perturbation .", "sentence_id": 5}
+{"abstract_id": "24754203", "label": "methods", "text": "Maximal voluntary contraction and force steadiness was measured for shoulder elevation .", "sentence_id": 6}
+{"abstract_id": "24754203", "label": "results", "text": "At follow-up , there was a significant between-group difference in the Romberg test with closed eyes only ( @ % confidence ellipse area ; CG : @ + / - @ mm@ ; TG : @ + / - @ mm@ ) .", "sentence_id": 7}
+{"abstract_id": "24754203", "label": "results", "text": "Prior to randomization , there were no significant differences in postural control and steadiness between @ pilots who experienced neck pain within the previous @ mo and @ pilots without such pain .", "sentence_id": 8}
+{"abstract_id": "24754203", "label": "conclusions", "text": "Impaired postural control and steadiness may only be quantifiable in individuals experiencing acute neck pain of certain intensity , and there may be a ceiling effect in the ability to improve these parameters .", "sentence_id": 9}
+{"abstract_id": "24754203", "label": "conclusions", "text": "For individuals with highly developed physiological capacity , a battery of tests with more stringent demands should be considered , e.g. , increased number of repetitions , prolonged duration of the tests , or testing with eyes closed .", "sentence_id": 10}
+{"abstract_id": "25140041", "label": "objective", "text": "The aim of this study was to assess the degree of fluctuation of osteitis on MRI during long-term treatment with etanercept ( ETN ) in patients with early axial SpA ( axSpA ) with active inflammation ( osteitis ) on whole-body MRI in the spine and/or the SI joints at baseline .", "sentence_id": 0}
+{"abstract_id": "25140041", "label": "methods", "text": "We analysed MRI data from @ SI joint quadrants and @ spine vertebral units ( VUs ) in terms of osteitis in the pooled data set of @ patients who were treated with ETN for @ consecutive years .", "sentence_id": 1}
+{"abstract_id": "25140041", "label": "methods", "text": "Scoring was performed by two blinded radiologists at baseline , year @ and year @ .", "sentence_id": 2}
+{"abstract_id": "25140041", "label": "results", "text": "Through years @ and @ , osteitis on MRI resolved completely in @ of @ ( @ % ) SI joint quadrants and in @ of @ ( @ % ) VUs affected at baseline , while persistent osteitis was found in @ of @ ( @ % ) SI joint quadrants and in @ of @ ( @ % ) spine VUs .", "sentence_id": 3}
+{"abstract_id": "25140041", "label": "results", "text": "The development of new osteitis in sites that were free of osteitis at baseline only occurred in @ of @ ( @ % ) SI joint quadrants and in @ of @ ( @ % ) spine VUs in both year @ and year @ .", "sentence_id": 4}
+{"abstract_id": "25140041", "label": "conclusions", "text": "There was a consistently small amount of osteitis on MRI in patients with early axSpA compared with baseline values , and only a very low rate of new-onset osteitis was found during @ years of continuous treatment with ETN .", "sentence_id": 5}
+{"abstract_id": "24615217", "label": "objective", "text": "Current tobacco use treatment approaches require smokers to request treatment or depend on the provider to initiate smoking cessation care and are therefore reactive .", "sentence_id": 0}
+{"abstract_id": "24615217", "label": "objective", "text": "Most smokers do not receive evidence-based treatments for tobacco use that include both behavioral counseling and pharmacotherapy .", "sentence_id": 1}
+{"abstract_id": "24615217", "label": "objective", "text": "To assess the effect of a proactive , population-based tobacco cessation care model on use of evidence-based tobacco cessation treatments and on population-level smoking cessation rates ( ie , abstinence among all smokers including those who use and do not use treatment ) compared with usual care among a diverse population of current smokers .", "sentence_id": 2}
+{"abstract_id": "24615217", "label": "methods", "text": "The Veterans Victory Over Tobacco Study , a pragmatic randomized clinical trial involving a population-based registry of current smokers aged @ to @ years .", "sentence_id": 3}
+{"abstract_id": "24615217", "label": "methods", "text": "A total of @ current smokers , identified using the Department of Veterans Affairs ( VA ) electronic medical record , were randomized prior to contact to evaluate both the reach and effectiveness of the proactive care intervention .", "sentence_id": 4}
+{"abstract_id": "24615217", "label": "methods", "text": "Current smokers were randomized to usual care or proactive care .", "sentence_id": 5}
+{"abstract_id": "24615217", "label": "methods", "text": "Proactive care combined ( @ ) proactive outreach and ( @ ) offer of choice of smoking cessation services ( telephone or in-person ) .", "sentence_id": 6}
+{"abstract_id": "24615217", "label": "methods", "text": "Proactive outreach included mailed invitations followed by telephone outreach to motivate smokers to seek treatment with choice of services .", "sentence_id": 7}
+{"abstract_id": "24615217", "label": "methods", "text": "The primary outcome was @-month prolonged smoking abstinence at @ year and was assessed by a follow-up survey among all current smokers regardless of interest in quitting or treatment utilization .", "sentence_id": 8}
+{"abstract_id": "24615217", "label": "results", "text": "A total of @ participants were included in the primary analysis .", "sentence_id": 9}
+{"abstract_id": "24615217", "label": "results", "text": "The follow-up survey response rate was @ % .", "sentence_id": 10}
+{"abstract_id": "24615217", "label": "results", "text": "The population-level , @-month prolonged smoking abstinence rate at @ year was @ % for proactive care compared with @ % for usual care ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24615217", "label": "results", "text": "Logistic regression mixed model analysis showed a significant effect of the proactive care intervention on @-month prolonged abstinence ( odds ratio -LSB- OR -RSB- , @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "24615217", "label": "results", "text": "In analyses accounting for nonresponse using likelihood-based not-missing-at-random models , the effect of proactive care on @-month prolonged abstinence persisted ( OR , @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "24615217", "label": "conclusions", "text": "Proactive , population-based tobacco cessation care using proactive outreach to connect smokers to evidence-based telephone or in-person smoking cessation services is effective for increasing long-term population-level cessation rates .", "sentence_id": 14}
+{"abstract_id": "26115073", "label": "objective", "text": "To investigate the effects of multimodal supervised exercise on physical functioning , falls , and related injuries in older women .", "sentence_id": 0}
+{"abstract_id": "26115073", "label": "methods", "text": "Two-year randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "26115073", "label": "methods", "text": "Tampere , Finland .", "sentence_id": 2}
+{"abstract_id": "26115073", "label": "methods", "text": "Women aged @ to @ who had fallen in the previous year ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "26115073", "label": "methods", "text": "Participants were randomly assigned to an exercise or control group ( ClinicalTrial.gov NCT@ ) .", "sentence_id": 4}
+{"abstract_id": "26115073", "label": "methods", "text": "Exercisers participated in group exercise classes twice a week for @ months and once a week for the subsequent @ months and home exercises .", "sentence_id": 5}
+{"abstract_id": "26115073", "label": "methods", "text": "Controls maintained their current physical activity .", "sentence_id": 6}
+{"abstract_id": "26115073", "label": "methods", "text": "Physical functioning assessed at baseline and at @-month intervals during the intervention .", "sentence_id": 7}
+{"abstract_id": "26115073", "label": "methods", "text": "Falls and related injuries monitored with fall diaries .", "sentence_id": 8}
+{"abstract_id": "26115073", "label": "results", "text": "Intention-to-treat analyses showed that exercise led to significant improvements in physical functioning .", "sentence_id": 9}
+{"abstract_id": "26115073", "label": "results", "text": "Leg strength differed significantly between the groups ( mean change : @ % , @ % confidence interval ( CI ) = @ to @ in exercisers ; @ % , @ % CI = -@ to @ in controls ; P < @ ) .", "sentence_id": 10}
+{"abstract_id": "26115073", "label": "results", "text": "Chair stand time also differed significantly between groups ( @ % , @ % CI @ to @ % in exercisers ; @ % , @ % CI = -@ to @ ) in controls ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "26115073", "label": "results", "text": "Between-group differences were significant for fast walking speed ( P = @ ) and probability of completing the backward walking test ( P < @ ) , favoring exercisers .", "sentence_id": 12}
+{"abstract_id": "26115073", "label": "results", "text": "Timed Up-and-Go and grip strength did not differ between groups .", "sentence_id": 13}
+{"abstract_id": "26115073", "label": "results", "text": "There was no difference in the total falls incidence rate ratio ( IRR = @ , @ % CI = @ to @ ) , but exercisers were less likely to have medically attended injurious falls ( IRR = @ , @ % CI = @ to @ ; P = @ ) .", "sentence_id": 14}
+{"abstract_id": "26115073", "label": "conclusions", "text": "Twenty-four months of multimodal exercise enhanced physical functioning in women aged @ to @ with a history of falls .", "sentence_id": 15}
+{"abstract_id": "26115073", "label": "conclusions", "text": "Although the total number of falls was not lower than in controls , the rate of medically attended injurious falls was more than @ % lower .", "sentence_id": 16}
+{"abstract_id": "24321006", "label": "objective", "text": "To test the strength of the association between parental monitoring trajectories throughout early adolescence ( ages @-@ ) and gambling behaviours by young adulthood ( age @ ) .", "sentence_id": 0}
+{"abstract_id": "24321006", "label": "methods", "text": "Longitudinal cohort design .", "sentence_id": 1}
+{"abstract_id": "24321006", "label": "methods", "text": "Baltimore , Maryland .", "sentence_id": 2}
+{"abstract_id": "24321006", "label": "methods", "text": "The sample of @ participants with gambling data between ages @-@ and parental monitoring data between ages @-@ were predominantly African American and received subsidized lunches at age @ .", "sentence_id": 3}
+{"abstract_id": "24321006", "label": "methods", "text": "The South Oaks Gambling Screen and South Oaks Gambling Screen-Revised for Adolescents collected self-reports on annual gambling and gambling problems between ages @-@ .", "sentence_id": 4}
+{"abstract_id": "24321006", "label": "methods", "text": "The Parental Monitoring Subscale of the Structured Interview of Parent Management Skills and Practices-Youth Version collected self-reports on annual parental monitoring between ages @-@ .", "sentence_id": 5}
+{"abstract_id": "24321006", "label": "results", "text": "General growth mixture modelling identified two parental monitoring trajectories : ( i ) ` stable ' class ( @ % ) began with a high level of parental monitoring at age @ that remained steady to age @ ; ( ii ) ` declining ' class ( @ % ) began with a significantly lower level of parental monitoring at age @ and experienced a significant to through age @ .", "sentence_id": 6}
+{"abstract_id": "24321006", "label": "results", "text": "The declining class had increased significantly unadjusted ( OR = @ ; @ % CI = @ , @ ; P@ @ ) and adjusted ( aOR = @ ; @ % CI = @ , @ ; P = @ ) odds of problem gambling compared with non-gambling .", "sentence_id": 7}
+{"abstract_id": "24321006", "label": "conclusions", "text": "Low and/or declining parental monitoring of children between the ages of @ and @ is associated significantly with problem gambling when those children reach young adulthood .", "sentence_id": 8}
+{"abstract_id": "25575084", "label": "methods", "text": "Prospective randomized controlled multicenter study .", "sentence_id": 0}
+{"abstract_id": "25575084", "label": "objective", "text": "To compare the effect of X-Stop with minimally invasive decompression ( MID ) in patients with neurogenic intermittent claudication due to lumbar spinal stenosis .", "sentence_id": 1}
+{"abstract_id": "25575084", "label": "background", "text": "Lumbar spinal stenosis is the most common indication for operative treatment in elderly .", "sentence_id": 2}
+{"abstract_id": "25575084", "label": "background", "text": "Laminectomy has been the `` gold standard , '' but MID is now widely used .", "sentence_id": 3}
+{"abstract_id": "25575084", "label": "background", "text": "Another minimally invasive surgery option is X-Stop showing good result compared with nonoperative treatment , but showing higher reoperation rate than laminectomy .", "sentence_id": 4}
+{"abstract_id": "25575084", "label": "methods", "text": "We enrolled @ patients aged @ to @ years , with symptoms of neurogenic intermittent claudication within @-m walking distance and @ - or @-level lumbar spinal stenosis , randomized to either MID or X-Stop .", "sentence_id": 5}
+{"abstract_id": "25575084", "label": "methods", "text": "Primary outcome was Zurich Claudication Questionnaire in this intention-to-treat analysis .", "sentence_id": 6}
+{"abstract_id": "25575084", "label": "methods", "text": "Secondary outcome was Oswestry Disability Index , EuroQol @-dimensional questionnaire , numerical rating scale @ for lower back pain and leg pain , and risk for secondary surgery and complications .", "sentence_id": 7}
+{"abstract_id": "25575084", "label": "results", "text": "No significant differences were found in Zurich Claudication Questionnaire between the groups at any follow-ups .", "sentence_id": 8}
+{"abstract_id": "25575084", "label": "results", "text": "Both groups had a statistical and clinical significant improvement at @ weeks and throughout the @-year observation period .", "sentence_id": 9}
+{"abstract_id": "25575084", "label": "results", "text": "The number of patients having secondary surgery due to persistent or recurrent symptoms was significantly higher in the X-Stop group , odds ratio ( @ % confidence interval ) = @ ( @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25575084", "label": "results", "text": "Complication rate was similar and low , but more severe for MID .", "sentence_id": 11}
+{"abstract_id": "25575084", "label": "conclusions", "text": "Both MID and X-Stop led to significant symptom improvements .", "sentence_id": 12}
+{"abstract_id": "25575084", "label": "conclusions", "text": "There were no significant clinical differences in effect between the methods at any of the follow-up time points .", "sentence_id": 13}
+{"abstract_id": "25575084", "label": "conclusions", "text": "X-Stop had significant higher risk of secondary surgery .", "sentence_id": 14}
+{"abstract_id": "25575084", "label": "conclusions", "text": "Complication was more severe for MID .", "sentence_id": 15}
+{"abstract_id": "25428762", "label": "background", "text": "In clinical practice , nonsteroidal anti-inflammatory drugs ( NSAIDs ) are commonly discontinued after response to biologic therapy is achieved in patients with axial spondyloarthritis ( axSpA ) , but the impact of NSAID discontinuation has not been assessed in prospective controlled trials .", "sentence_id": 0}
+{"abstract_id": "25428762", "label": "background", "text": "The aim of the SPARSE study was to evaluate the effects of the anti-tumor necrosis factor agent etanercept on NSAID intake and conventional clinical outcomes in axSpA patients .", "sentence_id": 1}
+{"abstract_id": "25428762", "label": "methods", "text": "In the double-blind , placebo-controlled period , patients with active ( mini Bath Ankylosing Spondylitis Disease Activity Index ( BASDAI ) @ ) axSpA despite optimal NSAID intake were randomized to receive etanercept @mg or placebo once weekly for @weeks .", "sentence_id": 2}
+{"abstract_id": "25428762", "label": "methods", "text": "All patients were advised to taper/discontinue their NSAID intake during the treatment period .", "sentence_id": 3}
+{"abstract_id": "25428762", "label": "methods", "text": "NSAID intake was self-reported by diary and Assessment of SpondyloArthritis International Society ( ASAS ) - NSAID scores calculated based on ASAS recommendations .", "sentence_id": 4}
+{"abstract_id": "25428762", "label": "methods", "text": "The primary endpoint was change from baseline to week @ in ASAS-NSAID score ( analysis of covariance ) .", "sentence_id": 5}
+{"abstract_id": "25428762", "label": "results", "text": "In @ randomized patients at baseline , mean age ( standard deviation ) was @ ( @ ) years ; disease duration , @ ( @ ) years ; @/@ ( @ % ) were human leukocyte antigen-B@ positive ; @/@ ( @ % ) had radiographic sacroiliitis ; and @/@ ( @ % ) were magnetic resonance imaging sacroiliitis-positive .", "sentence_id": 6}
+{"abstract_id": "25428762", "label": "results", "text": "Mean ASAS-NSAID scores were similar between etanercept and placebo groups at baseline ( @ ( @ ) versus @ ( @ ) ) , as were BASDAI ( @ ( @ ) versus @ ( @ ) ) , and Bath Ankylosing Spondylitis Functional Index ( @ ( @ ) versus @ ( @ ) ) .", "sentence_id": 7}
+{"abstract_id": "25428762", "label": "results", "text": "Mean changes ( SE ) in ASAS-NSAID score from baseline to week @ were -@ ( @ ) and -@ ( @ ) in the etanercept and placebo groups ( between-group difference , -@ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25428762", "label": "results", "text": "Significantly higher proportions of patients receiving etanercept versus placebo had an ASAS-NSAID score < @ ( @ % versus @ % ; P = @ ) and ASAS-NSAID score of @ ( @ % versus @ % ; P = @ ) at this time point .", "sentence_id": 9}
+{"abstract_id": "25428762", "label": "results", "text": "Significantly more patients in the etanercept versus placebo group achieved BASDAI@ ( @ % versus @ % ; P = @ ) and ASAS@ ( @ % versus @ % ; P = @ ) at week @ .", "sentence_id": 10}
+{"abstract_id": "25428762", "label": "conclusions", "text": "In patients with axSpA , etanercept was associated with clinically relevant NSAID-sparing effects in addition to significant improvements in conventional clinical outcomes .", "sentence_id": 11}
+{"abstract_id": "24797294", "label": "objective", "text": "Antimicrobial treatment reduces the symptoms of acute otitis media ( AOM ) .", "sentence_id": 0}
+{"abstract_id": "24797294", "label": "objective", "text": "The effect of antimicrobial treatment on the duration of middle ear effusion ( MEE ) and concomitant hearing impairment is not known .", "sentence_id": 1}
+{"abstract_id": "24797294", "label": "objective", "text": "To determine whether the antimicrobial treatment of AOM reduces the duration of MEE .", "sentence_id": 2}
+{"abstract_id": "24797294", "label": "methods", "text": "This randomized , double-blind , placebo-controlled trial involved a total of @ children with AOM between @ months and @ years of age .", "sentence_id": 3}
+{"abstract_id": "24797294", "label": "methods", "text": "Participants were recruited from September @ , @ , to January @ , @ ; October @ , @ , to December @ , @ ; and September @ , @ , to June @ , @ , from among children attending an AOM prevention trial and children visiting local outpatient clinics in Oulu , Finland .", "sentence_id": 4}
+{"abstract_id": "24797294", "label": "methods", "text": "Children were randomly allocated to receive either @ mg/kg of amoxicillin-clavulanate or a placebo mixture per day for @ days .", "sentence_id": 5}
+{"abstract_id": "24797294", "label": "methods", "text": "The primary outcome measure was the time to the disappearance of MEE as defined by a normal tympanogram finding ( A curve ) from both ears on @ consecutive measurement days .", "sentence_id": 6}
+{"abstract_id": "24797294", "label": "methods", "text": "Parents performed daily tympanometry at home .", "sentence_id": 7}
+{"abstract_id": "24797294", "label": "methods", "text": "The study physician performed tympanometry and otoscopy at study entry , after @ and @ days , and then weekly until both ears were healthy .", "sentence_id": 8}
+{"abstract_id": "24797294", "label": "methods", "text": "The main secondary outcome measures were the time to normal otoscopy findings and the proportion of children without persistent MEE at @ days and @ months .", "sentence_id": 9}
+{"abstract_id": "24797294", "label": "results", "text": "Middle ear effusion disappeared @ weeks ( @ days ) earlier ( P = @ ) in the antimicrobial group ( mean time , @ weeks ; @ % CI , @-@ @ ) than in the placebo group ( @ weeks ; @ % CI , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24797294", "label": "results", "text": "Normal otoscopy findings were observed @ weeks sooner in the antimicrobial group than in the placebo group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24797294", "label": "results", "text": "On day @ , @ % of children in the antimicrobial group and @ % in the placebo group had normal tympanometry findings ( number needed to treat , @ ; @ % CI , @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "24797294", "label": "results", "text": "On day @ , @ children ( @ % ) in the antimicrobial group and @ children ( @ % ) in the placebo group had persistent MEE ( P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24797294", "label": "conclusions", "text": "Antimicrobial treatment effectively reduced the duration of MEE and possible concomitant hearing impairment in children with AOM .", "sentence_id": 14}
+{"abstract_id": "24797294", "label": "conclusions", "text": "Antimicrobial treatment also reduced the risk for persistent MEE .", "sentence_id": 15}
+{"abstract_id": "24532523", "label": "objective", "text": "Although the analgesic effects of corticosteroids have been well documented , little information is available on periarticular injection ( PI ) containing corticosteroids for early postoperative pain management after total knee arthroplasty ( TKA ) .", "sentence_id": 0}
+{"abstract_id": "24532523", "label": "objective", "text": "We performed a prospective double-blind randomized trial to evaluate the efficacy and safety of an intraoperative corticosteroid PI in patients undergoing TKA .", "sentence_id": 1}
+{"abstract_id": "24532523", "label": "methods", "text": "Seventy-six consecutive female patients undergoing bilateral staged TKA were randomized to receive steroid or non-steroid PI , with @ months separating the procedures .", "sentence_id": 2}
+{"abstract_id": "24532523", "label": "methods", "text": "The steroid group received PI with a mixture containing triamcinolone acetonide ( @ mg ) .", "sentence_id": 3}
+{"abstract_id": "24532523", "label": "methods", "text": "The non-steroid group received the same injection mixture without corticosteroid .", "sentence_id": 4}
+{"abstract_id": "24532523", "label": "methods", "text": "During the postoperative period , nighttime pain , functional recovery -LSB- straight leg raising ( SLR ) ability and maximal flexion -RSB- , patient satisfaction , and complications were recorded .", "sentence_id": 5}
+{"abstract_id": "24532523", "label": "methods", "text": "Short-term postoperative clinical scores and patient satisfaction were evaluated at @ months .", "sentence_id": 6}
+{"abstract_id": "24532523", "label": "results", "text": "The pain level was significantly lower in the PI steroid than the non-steroid group on the night of the operation ( VAS , @ vs. @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24532523", "label": "results", "text": "Rebound pain was observed in both groups at POD@ ( VAS , @ vs. @ ; p = @ ) , but pain remained at a low level thereafter .", "sentence_id": 8}
+{"abstract_id": "24532523", "label": "results", "text": "No significant differences were seen in maximal flexion , frequency of acute rescuer , clinical scores , and patient satisfaction .", "sentence_id": 9}
+{"abstract_id": "24532523", "label": "results", "text": "The steroid group was able to perform SLR earlier than the non-steroid group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24532523", "label": "results", "text": "The incidence of complications was similar between the groups .", "sentence_id": 11}
+{"abstract_id": "24532523", "label": "conclusions", "text": "PI containing a corticosteroid provided an additional pain-relieving effect on the night of the operation .", "sentence_id": 12}
+{"abstract_id": "24532523", "label": "conclusions", "text": "In addition , corticosteroid PI did not increase the perioperative complications of TKA .", "sentence_id": 13}
+{"abstract_id": "24592578", "label": "objective", "text": "Our aim was to characterize articulation proficiency and differences between tumor sites before and after chemoradiotherapy for advanced head and neck cancer with the help of acoustic measures .", "sentence_id": 0}
+{"abstract_id": "24592578", "label": "objective", "text": "Our further goal was to improve objective speech measures and gain insight into muscle functioning before and after treatment .", "sentence_id": 1}
+{"abstract_id": "24592578", "label": "methods", "text": "In @ patients with laryngeal or hypopharyngeal , nasal or nasopharyngeal , or oral or oropharyngeal cancer , we acoustically analyzed nasality , vowel space , precision , and strength of articulation in @ speech sounds ( / a / , / i / , / u / , / p / , / s / , / z / , / @ / , / t / , / tj / , / k / , / x / , / r / ) before treatment and @ weeks and @ year after treatment .", "sentence_id": 2}
+{"abstract_id": "24592578", "label": "methods", "text": "Outcomes were compared between assessment points and between tumor sites .", "sentence_id": 3}
+{"abstract_id": "24592578", "label": "results", "text": "Nasality in nonlaryngeal sites was significantly reduced by treatment .", "sentence_id": 4}
+{"abstract_id": "24592578", "label": "results", "text": "Most affected in articulation were the oral or oropharyngeal cancer sites , followed by the nasal or nasopharyngeal sites .", "sentence_id": 5}
+{"abstract_id": "24592578", "label": "results", "text": "One year after treatment , vowel space had not recovered and consonant articulation had weakened .", "sentence_id": 6}
+{"abstract_id": "24592578", "label": "results", "text": "Laryngeal sites were less affected in articulation by tumor or treatment .", "sentence_id": 7}
+{"abstract_id": "24592578", "label": "conclusions", "text": "Analyses of articulatory-acoustic features are a useful instrument for assessing articulation and speech quality objectively .", "sentence_id": 8}
+{"abstract_id": "24592578", "label": "conclusions", "text": "Assessment of a number of sounds representing various articulation manners , places , and tongue shapes revealed patterns of speech deterioration after chemoradiotherapy .", "sentence_id": 9}
+{"abstract_id": "24592578", "label": "conclusions", "text": "The results suggest that patients ' speech could benefit from articulation exercises to address changes in muscle coordination and/or sensitivity and to counteract side effects and `` underexercise '' atrophy .", "sentence_id": 10}
+{"abstract_id": "25194409", "label": "background", "text": "The aim of this study was to assess the effects of pioglitazone on blood glucose control and inflammatory biomarkers in diabetic patients receiving insulin after kidney transplantation .", "sentence_id": 0}
+{"abstract_id": "25194409", "label": "methods", "text": "In a randomized placebo-controlled trial , @ diabetic kidney transplant patients were followed for @ months after randomly assigned to placebo and pioglitazone ( @ mg/d ) groups .", "sentence_id": 1}
+{"abstract_id": "25194409", "label": "methods", "text": "All of the patients continued their insulin therapy irrespective of the group that they were assigned to , in order to evaluate the effects of addition of pioglitazone on blood glucose and inflammation biomarkers including serum C-reactive protein , high-sensitivity C-reactive protein , and interleukin-@ levels , as well as erythrocyte sedimentation rate .", "sentence_id": 2}
+{"abstract_id": "25194409", "label": "results", "text": "At baseline , there were no significant differences in laboratory studies between the two groups .", "sentence_id": 3}
+{"abstract_id": "25194409", "label": "results", "text": "After @ months of intervention , along with significant improvement in hemoglobin A@c in the pioglitazone group , daily insulin requirements also decreased and lipid profile improved significantly .", "sentence_id": 4}
+{"abstract_id": "25194409", "label": "results", "text": "In addition , erythrocyte sedimentation rate , C-reactive protein , and high-sensitivity C-reactive protein values were significantly lower in the pioglitazone group ( P = @ , P < @ , and P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25194409", "label": "results", "text": "Interleukin-@ levels were not significantly different at the end of the study between the two groups , but it had a decreasing trend in the pioglitazone group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25194409", "label": "conclusions", "text": "Pioglitazone complementing insulin in diabetic kidney transplant patients not only improved glycemic control , evidenced by hemoglobin A@c , and reduced daily insulin requirement , but also decreased inflammatory markers which may have an impact on overall cardiovascular events and mortalities beyond glycemic control .", "sentence_id": 7}
+{"abstract_id": "24738701", "label": "background", "text": "Gut microbiota modifiers may have beneficial effects of non-alcoholic fatty liver disease ( NAFLD ) but randomised controlled trials ( RCT ) are lacking in children .", "sentence_id": 0}
+{"abstract_id": "24738701", "label": "objective", "text": "To perform a double-blind RCT of VSL # @ vs. placebo in obese children with biopsy-proven NAFLD .", "sentence_id": 1}
+{"abstract_id": "24738701", "label": "methods", "text": "Of @ randomised children , @ ( @ VSL # @ and @ placebo ) completed the study .", "sentence_id": 2}
+{"abstract_id": "24738701", "label": "methods", "text": "The main outcome was the change in fatty liver severity at @ months as detected by ultrasonography .", "sentence_id": 3}
+{"abstract_id": "24738701", "label": "methods", "text": "Secondary outcomes were the changes in triglycerides , insulin resistance as detected by the homoeostasis model assessment ( HOMA ) , alanine transaminase ( ALT ) , body mass index ( BMI ) , glucagon-like peptide @ ( GLP-@ ) and activated GLP-@ ( aGLP-@ ) .", "sentence_id": 4}
+{"abstract_id": "24738701", "label": "methods", "text": "Ordinal and linear models with cluster confidence intervals were used to evaluate the efficacy of VSL # @ vs. placebo at @ months .", "sentence_id": 5}
+{"abstract_id": "24738701", "label": "results", "text": "At baseline , moderate and severe NAFLD were present in @ % and @ % of PLA children and in @ % and @ % of VSL # @ children .", "sentence_id": 6}
+{"abstract_id": "24738701", "label": "results", "text": "The probability that children supplemented with VSL # @ had none , light , moderate or severe FL at the end of the study was @ % , @ % , @ % and @ % respectively with corresponding values of @ % , @ % , @ % and @ % for the placebo group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24738701", "label": "results", "text": "No between-group differences were detected in triglycerides , HOMA and ALT while BMI decreased and GLP-@ and aGLP@ increased in the VSL # @ group ( P < @ for all comparisons ) .", "sentence_id": 8}
+{"abstract_id": "24738701", "label": "conclusions", "text": "A @-month supplement of VSL # @ significantly improves NAFLD in children .", "sentence_id": 9}
+{"abstract_id": "24738701", "label": "conclusions", "text": "The VSL # @-dependent GLP-@ increase could be responsible for these beneficial effects .", "sentence_id": 10}
+{"abstract_id": "24738701", "label": "conclusions", "text": "Trial identifier : NCT@ ( www.clinicaltrial.gov ) .", "sentence_id": 11}
+{"abstract_id": "24308025", "label": "background", "text": "Exposure to electromagnetic fields has been reported to have analgesic and antinociceptive effects in several organisms .", "sentence_id": 0}
+{"abstract_id": "24308025", "label": "objective", "text": "To test the effect of very low-intensity transcranial magnetic stimulation on symptoms associated with fibromyalgia syndrome .", "sentence_id": 1}
+{"abstract_id": "24308025", "label": "methods", "text": "A double-blinded , placebo-controlled clinical trial was performed in the Sagrado Corazn Hospital , Seville , Spain .", "sentence_id": 2}
+{"abstract_id": "24308025", "label": "methods", "text": "Female fibromyalgia patients ( @ to @ years of age ) were randomly assigned to either a stimulation group or a sham group .", "sentence_id": 3}
+{"abstract_id": "24308025", "label": "methods", "text": "The stimulation group ( n = @ ) was stimulated using @ Hz pulsed magnetic fields of very low intensity , while the sham group ( n = @ ) underwent the same protocol without stimulation .", "sentence_id": 4}
+{"abstract_id": "24308025", "label": "methods", "text": "Pressure pain thresholds before and after stimulation were determined using an algometer during the eight consecutive weekly sessions of the trial .", "sentence_id": 5}
+{"abstract_id": "24308025", "label": "methods", "text": "In addition , blood serotonin levels were measured and patients completed questionnaires to monitor symptom evolution .", "sentence_id": 6}
+{"abstract_id": "24308025", "label": "results", "text": "A repeated-measures ANOVA indicated statistically significant improvement in the stimulation group compared with the control group with respect to somatosensory pain thresholds , ability to perform daily activities , perceived chronic pain and sleep quality .", "sentence_id": 7}
+{"abstract_id": "24308025", "label": "results", "text": "While improvement in pain thresholds was apparent after the first stimulation session , improvement in the other three measures occurred after the sixth week .", "sentence_id": 8}
+{"abstract_id": "24308025", "label": "results", "text": "No significant between-group differences were observed in scores of depression , fatigue , severity of headaches or serotonin levels .", "sentence_id": 9}
+{"abstract_id": "24308025", "label": "results", "text": "No adverse side effects were reported in any of the patients .", "sentence_id": 10}
+{"abstract_id": "24308025", "label": "conclusions", "text": "Very low-intensity magnetic stimulation may represent a safe and effective treatment for chronic pain and other symptoms associated with fibromyalgia .", "sentence_id": 11}
+{"abstract_id": "24884779", "label": "background", "text": "The increasing prevalence of cardiometabolic disease ( CMD ) in combination with an ageing population is a major public health problem .", "sentence_id": 0}
+{"abstract_id": "24884779", "label": "background", "text": "Early detection and management of individuals at risk for CMD is required to prevent future health problems with associated costs .", "sentence_id": 1}
+{"abstract_id": "24884779", "label": "background", "text": "General practice is the optimal health care setting to accomplish this goal .", "sentence_id": 2}
+{"abstract_id": "24884779", "label": "background", "text": "Prevention programs for identification and treatment of patients with an increased risk for CMD in primary care have been proven feasible .", "sentence_id": 3}
+{"abstract_id": "24884779", "label": "background", "text": "However , the effectiveness and cost-effectiveness have yet to be demonstrated .", "sentence_id": 4}
+{"abstract_id": "24884779", "label": "background", "text": "The ` Personalized Prevention Approach for CardioMetabolic Risk ' ( PPA CMR ) is such a prevention program .", "sentence_id": 5}
+{"abstract_id": "24884779", "label": "background", "text": "The objective of the INTEGRATE study is to investigate the effectiveness and cost-effectiveness of PPA CMR , as well as to establish determinants for participation and compliance .", "sentence_id": 6}
+{"abstract_id": "24884779", "label": "methods", "text": "The INTEGRATE study is designed as a stepped-wedge randomized controlled trial with a waiting list control group .", "sentence_id": 7}
+{"abstract_id": "24884779", "label": "methods", "text": "In approximately @ general practices , all enlisted patients without CMD aged @-@ years , are invited to participate in PPA CMR .", "sentence_id": 8}
+{"abstract_id": "24884779", "label": "methods", "text": "After an online risk estimation , patients with a score above risk threshold are invited to the GP for additional measurements , detailed risk profiling and tailored treatment of risk factors through medication and/or lifestyle counseling .", "sentence_id": 9}
+{"abstract_id": "24884779", "label": "methods", "text": "At baseline and after twelve months of follow-up lifestyle , health and work status of all participants are established with online questionnaires .", "sentence_id": 10}
+{"abstract_id": "24884779", "label": "methods", "text": "Additionally after twelve months , we will determine health care utilization , costs of PPA CMR and compliance .", "sentence_id": 11}
+{"abstract_id": "24884779", "label": "methods", "text": "Primary endpoints are the number of newly detected patients with CMD and changes in individual risk factors between the intervention and waiting list control group .", "sentence_id": 12}
+{"abstract_id": "24884779", "label": "methods", "text": "Medical data will be extracted from the GPs ' electronic medical records .", "sentence_id": 13}
+{"abstract_id": "24884779", "label": "methods", "text": "In order to assess factors related to participation , we will send questionnaires to non-participants and assess characteristics of participating practices .", "sentence_id": 14}
+{"abstract_id": "24884779", "label": "methods", "text": "For all participants , additional demographic characteristics will be available through Statistics Netherlands .", "sentence_id": 15}
+{"abstract_id": "24884779", "label": "conclusions", "text": "The INTEGRATE study will provide insight into the effectiveness and cost-effectiveness of PPA CMR as well as determinants for participation and compliance , which represents essential information to guide further large-scale implementation of primary prevention programs for CMD .", "sentence_id": 16}
+{"abstract_id": "25920944", "label": "objective", "text": "To investigate whether different study-to-participant communication methods increase response , increase response from hard-to-engage individuals , and influence participants ' consent decisions .", "sentence_id": 0}
+{"abstract_id": "25920944", "label": "methods", "text": "A randomized controlled trial within the Avon Longitudinal Study of Parents and Children .", "sentence_id": 1}
+{"abstract_id": "25920944", "label": "methods", "text": "Cohort members were invited to re-enroll at age @ and consent to linkage to their health and administrative records .", "sentence_id": 2}
+{"abstract_id": "25920944", "label": "methods", "text": "Participants were randomized to receive one of eight combinations of three interventions : a prior-notification postcard or no contact , a standard or professionally designed consent pack , and a phone or postal reminder .", "sentence_id": 3}
+{"abstract_id": "25920944", "label": "methods", "text": "The primary outcome was return of the consent form ( `` response '' ) , with consent decision being the secondary outcome .", "sentence_id": 4}
+{"abstract_id": "25920944", "label": "results", "text": "Of @,@ participants , @ ( @ % ) responded .", "sentence_id": 5}
+{"abstract_id": "25920944", "label": "results", "text": "Response rates were @ % higher ( @ % confidence interval : -@ , @ % ; P = @ ) among those receiving designed packs than among those receiving standard packs and @ % higher ( @ , @ % ; P = @ ) among those receiving phone reminders ( compared with postal reminders ) .", "sentence_id": 6}
+{"abstract_id": "25920944", "label": "results", "text": "The prior-notification postcard did not influence response rates -LSB- difference = @ % ( -@ , @ % ; P = @ ) -RSB- , and we found no evidence that the communication method influenced consent decision .", "sentence_id": 7}
+{"abstract_id": "25920944", "label": "conclusions", "text": "This trial provides evidence that communication material design can influence response rates and that phone reminders have superior cost/benefit returns over designed materials .", "sentence_id": 8}
+{"abstract_id": "25920944", "label": "conclusions", "text": "Experimental evaluation of communications strategies and dissemination of findings may benefit cohort studies .", "sentence_id": 9}
+{"abstract_id": "25741153", "label": "objective", "text": "To evaluate the necessity of endoscopic nasobiliary drainage ( ENBD ) catheter placement after clearance of common bile duct ( CBD ) stones .", "sentence_id": 0}
+{"abstract_id": "25741153", "label": "methods", "text": "Patients enrolled in this study were randomly divided into two groups , according to whether or not they received ENBD after the removal of CBD stones .", "sentence_id": 1}
+{"abstract_id": "25741153", "label": "methods", "text": "Group @ ( ENBD group ) was then subdivided into three groups : G@a patients received an endoscopic papillary balloon dilatation ( EPBD ) , G@b patients received an endoscopic sphincterotomy ( EST ) , and G@c patients received neither .", "sentence_id": 2}
+{"abstract_id": "25741153", "label": "methods", "text": "Group @ ( non-ENBD group ) patients were also subdivided into three groups ( G@a , G@b , and G@c ) , similar to Group @ .", "sentence_id": 3}
+{"abstract_id": "25741153", "label": "methods", "text": "The maximum CBD diameter , the time for C-reactive protein ( CRP ) to normalize , levels of serum amylase , total serum bilirubin ( TB ) and alanine aminotransferase ( ALT ) , and postoperative hospitalization duration ( PHD ) were measured .", "sentence_id": 4}
+{"abstract_id": "25741153", "label": "results", "text": "A total of @ patients ( @ males , @ females ) , with an average age of @ years , were enrolled in this study .", "sentence_id": 5}
+{"abstract_id": "25741153", "label": "results", "text": "One hundred and thirteen patients who received ENBD were included in Group @ , and @ patients who did not receive ENBD were included in Group @ .", "sentence_id": 6}
+{"abstract_id": "25741153", "label": "results", "text": "The baseline clinical characteristics were similar in both groups .", "sentence_id": 7}
+{"abstract_id": "25741153", "label": "results", "text": "There were no significant differences in post-endoscopic retrograde cholangiopancreatography ( ERCP ) - related complications when Groups @ and @ were compared .", "sentence_id": 8}
+{"abstract_id": "25741153", "label": "results", "text": "Seventy-seven patients underwent EPBD , and @ received an ENBD tube ( G@a ) and @ did not ( G@a ) .", "sentence_id": 9}
+{"abstract_id": "25741153", "label": "results", "text": "Seventy-three patients underwent EST , and @ patients received an ENBD tube ( G@b ) and @ did not ( G@b ) .", "sentence_id": 10}
+{"abstract_id": "25741153", "label": "results", "text": "The remaining @ patients underwent neither EPBD nor EST ; of these patients , @ received an ENBD tube ( G@c ) and @ did not ( G@c ) .", "sentence_id": 11}
+{"abstract_id": "25741153", "label": "results", "text": "For each of the three pairs of subgroups ( G@a vs G@a , G@b vs G@b , G@c vs G@c ) , there were no significant differences detected in the PHD or the time to normalization of CRP , TB and ALT .", "sentence_id": 12}
+{"abstract_id": "25741153", "label": "results", "text": "In the EPBD group , the incidence of post-ERCP pancreatitis , hyperamylasemia and overall patient complications was significantly higher for G@a ( post-ERCP pancreatitis : @/@ vs @/@ , P = @ ; hyperamylasemia : @/@ vs @/@ , P = @ ; overall patient complications : @/@ vs @/@ , P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25741153", "label": "conclusions", "text": "After successful CBD stone clearance , ENBD is only beneficial when an EPBD procedure has been performed .", "sentence_id": 14}
+{"abstract_id": "24708597", "label": "background", "text": "Asthma is the most prevalent chronic disease to complicate pregnancies worldwide , affecting around @ % of pregnant women in Australia .", "sentence_id": 0}
+{"abstract_id": "24708597", "label": "background", "text": "Oxidative stress and inflammation manifest during pregnancy ; however asthma in pregnancies further intensifies oxidative stress .", "sentence_id": 1}
+{"abstract_id": "24708597", "label": "background", "text": "Consumption of antioxidant-rich foods has been shown to be beneficial for asthma control in non-pregnant asthmatic adults .", "sentence_id": 2}
+{"abstract_id": "24708597", "label": "background", "text": "It has not been investigated whether antioxidant-rich foods can improve the elevated oxidative stress that occurs with asthma in pregnancy , thereby improving asthma control .", "sentence_id": 3}
+{"abstract_id": "24708597", "label": "background", "text": "The primary aim of this study is to determine whether increased consumption of antioxidant-rich foods for @ weeks will improve maternal asthma control , compared to standard dietary intake during pregnancy .", "sentence_id": 4}
+{"abstract_id": "24708597", "label": "methods", "text": "A @ week , parallel randomized controlled trial will be conducted .", "sentence_id": 5}
+{"abstract_id": "24708597", "label": "methods", "text": "One hundred and sixty eight pregnant women with mild , moderate , or severe asthma , currently using inhaled corticosteroids , and with poor diet quality , will be recruited at approximately@ weeks gestation .", "sentence_id": 6}
+{"abstract_id": "24708597", "label": "methods", "text": "Following a @ week run-in period , women will be randomized to either a @ week antioxidant intervention ( increased consumption of antioxidant-rich foods ( @ servings/day vegetables , @ servings/day fruit , @ servings/day grains ( mostly wholegrains ) , @-@ serving/week lean meat ) or standard pregnancy care .", "sentence_id": 7}
+{"abstract_id": "24708597", "label": "methods", "text": "The primary outcome is asthma control score ( decrease of @ , the minimally clinically significant change ) .", "sentence_id": 8}
+{"abstract_id": "24708597", "label": "methods", "text": "Secondary outcomes include plasma antioxidants , markers of oxidative stress , and time to , and number of , exacerbations .", "sentence_id": 9}
+{"abstract_id": "24708597", "label": "methods", "text": "With two-tailed t-tests at @ % power , a sample size of @ completions per group is required .", "sentence_id": 10}
+{"abstract_id": "24708597", "label": "methods", "text": "Allowing for a @ % retention including a @ % removal of women from the analysis due to non-compliance , we will recruit @ women .", "sentence_id": 11}
+{"abstract_id": "24708597", "label": "conclusions", "text": "It is expected that this @ week study will improve asthma control .", "sentence_id": 12}
+{"abstract_id": "24708597", "label": "conclusions", "text": "This is significant because asthma is the most prevalent condition to complicate pregnancies and contributes to poor maternal , neonatal and infant health outcomes .", "sentence_id": 13}
+{"abstract_id": "24708597", "label": "conclusions", "text": "Our research will provide the first evidence to show that , in pregnancy , consumption of antioxidant-rich foods is a key modifier of clinical asthma status .", "sentence_id": 14}
+{"abstract_id": "24708597", "label": "conclusions", "text": "This research is crucial for contributing to the evidence base to inform future guidelines given existing clinical and research gaps .", "sentence_id": 15}
+{"abstract_id": "25514079", "label": "objective", "text": "This study aimed to compare the clinical and radiographic success of preveneered posterior NuSmile and Kinder Krowns over one year and to assess the level of parental satisfaction with their esthetics .", "sentence_id": 0}
+{"abstract_id": "25514079", "label": "methods", "text": "Three trained operators placed @ crowns in a split-mouth design with a random allocation for @ participants ( mean age : @ years ) who received two , four , six , or eight crowns .", "sentence_id": 1}
+{"abstract_id": "25514079", "label": "methods", "text": "Blind assessment of the clinical and radiographic performance of the restorations was performed by four calibrated examiners after one year .", "sentence_id": 2}
+{"abstract_id": "25514079", "label": "methods", "text": "Results were analyzed by Fisher 's exact test and McNemar test .", "sentence_id": 3}
+{"abstract_id": "25514079", "label": "methods", "text": "Examiner reliability was determined by Cohen 's kappa score .", "sentence_id": 4}
+{"abstract_id": "25514079", "label": "methods", "text": "Visual analogue scale ( VAS ) was used to assess the level of parental satisfaction .", "sentence_id": 5}
+{"abstract_id": "25514079", "label": "results", "text": "All crowns but one were retained , and the majority ( @ percent ) had no facing fractures .", "sentence_id": 6}
+{"abstract_id": "25514079", "label": "results", "text": "Parental satisfaction was high ( @ / @ on the VAS ) .", "sentence_id": 7}
+{"abstract_id": "25514079", "label": "results", "text": "Primary maxillary first molar crowns had more occlusal facing fractures than their mandibular counterparts ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25514079", "label": "results", "text": "Primary mandibular second molar crowns showed more facing fractures than their maxillary counterparts ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25514079", "label": "results", "text": "Both types showed no statistical difference in most categories , but Kinder Krowns had more facing fractures ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25514079", "label": "conclusions", "text": "Posterior preveneered crowns have predictable durability at @ months while offering natural appearance to restored teeth .", "sentence_id": 11}
+{"abstract_id": "24231400", "label": "objective", "text": "To determine whether physical activity may affect cognitive performance in patients with Parkinson 's disease by measuring reaction times in patients participating in the Berlin BIG study .", "sentence_id": 0}
+{"abstract_id": "24231400", "label": "methods", "text": "Randomized controlled trial , rater-blinded .", "sentence_id": 1}
+{"abstract_id": "24231400", "label": "methods", "text": "Ambulatory care .", "sentence_id": 2}
+{"abstract_id": "24231400", "label": "methods", "text": "Patients with mild to moderate Parkinson 's disease ( N = @ ) were randomly allocated to @ treatment arms .", "sentence_id": 3}
+{"abstract_id": "24231400", "label": "methods", "text": "Outcome was measured at the termination of training and at follow-up @ weeks after baseline in @ patients ( completers ) .", "sentence_id": 4}
+{"abstract_id": "24231400", "label": "methods", "text": "Patients received @ hours of individual Lee Silverman Voice Treatment-BIG training ( BIG ; duration of treatment , @wk ) , @ hours of group training with Nordic Walking ( WALK ; duration of treatment , @wk ) , or nonsupervised domestic exercise ( HOME ; duration of instruction , @hr ) .", "sentence_id": 5}
+{"abstract_id": "24231400", "label": "methods", "text": "Cued reaction time ( cRT ) and noncued reaction time ( nRT ) .", "sentence_id": 6}
+{"abstract_id": "24231400", "label": "results", "text": "Differences between treatment groups in improvement in reaction times from baseline to intermediate and baseline to follow-up assessments were observed for cRT but not for nRT .", "sentence_id": 7}
+{"abstract_id": "24231400", "label": "results", "text": "Pairwise t test comparisons revealed differences in change in cRT at both measurements between BIG and HOME groups ( intermediate : -@ ms ; @ % confidence interval -LSB- CI -RSB- , -@ / -@ ; P = @ ; follow-up : @ms ; CI , -@ / -@ ; P = @ ) and between WALK and HOME groups ( intermediate : -@ ms ; CI , -@ / -@ ; P = @ ; follow-up : -@ ms ; CI , -@ / -@ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24231400", "label": "results", "text": "There was no difference between BIG and WALK groups ( intermediate : @ms ; CI , -@ / @ ; P = @ ; follow-up : @ms ; CI , -@ / @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24231400", "label": "conclusions", "text": "Supervised physical exercise with Lee Silverman Voice Treatment-BIG or Nordic Walking is associated with improvement in cognitive aspects of movement preparation .", "sentence_id": 10}
+{"abstract_id": "24806623", "label": "background", "text": "Curative treatment of upper gastrointestinal tract neoplasms is complex and associated with high morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "24806623", "label": "background", "text": "In general , the patients are already malnourished , and early postoperative enteral nutrition is recommended .", "sentence_id": 1}
+{"abstract_id": "24806623", "label": "background", "text": "However , there is no consensus concerning the best enteral access route in these cases .", "sentence_id": 2}
+{"abstract_id": "24806623", "label": "methods", "text": "A prospective randomized trial was performed from @ to @ with @ patients who underwent esophagectomy , total gastrectomy , or pancreaticoduodenectomy .", "sentence_id": 3}
+{"abstract_id": "24806623", "label": "methods", "text": "In all , @ patients declined to participate , and @ did not meet the inclusion criteria and were excluded .", "sentence_id": 4}
+{"abstract_id": "24806623", "label": "methods", "text": "Of the @ included patients , @ had nasoenteric tubes , and @ had a jejunostomy .", "sentence_id": 5}
+{"abstract_id": "24806623", "label": "results", "text": "The two groups were similar in demographic and clinical aspects .", "sentence_id": 6}
+{"abstract_id": "24806623", "label": "results", "text": "The nasoenteric ( NE ) and jejunostomy groups underwent early enteral therapy in @ and @ % of cases ( p > @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "24806623", "label": "results", "text": "The median length of enteral therapy use was less in the NE group ( @ vs. @ days ) , but the difference was not statistically significant .", "sentence_id": 8}
+{"abstract_id": "24806623", "label": "results", "text": "The NE group required introduction of parenteral therapy more frequently than the jejunostomy group ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24806623", "label": "results", "text": "Complications related to the enteral route occurred in @ and @ % of patients ( p > @ ) in the NE and jejunostomy groups , respectively .", "sentence_id": 10}
+{"abstract_id": "24806623", "label": "results", "text": "In the NE group , there were four losses and four tube obstructions .", "sentence_id": 11}
+{"abstract_id": "24806623", "label": "results", "text": "In the jejunostomy group , there were two losses , four obstructions , and two cases of leakage around the tube .", "sentence_id": 12}
+{"abstract_id": "24806623", "label": "results", "text": "In the latter group , patients who underwent therapy for a longer time had tubal complications ( p < @ ) and longer intensive care unit and hospital stays ( p < @ ) .", "sentence_id": 13}
+{"abstract_id": "24806623", "label": "conclusions", "text": "The two enteral routes were associated with the same number of complications .", "sentence_id": 14}
+{"abstract_id": "24806623", "label": "conclusions", "text": "However , the presence of a jejunostomy allowed enteral therapy for longer periods , especially in patients with complications , thus avoiding the need for parenteral nutrition .", "sentence_id": 15}
+{"abstract_id": "25631483", "label": "objective", "text": "To assess the efficacy and safety of intravitreal bevacizumab ( IVB ) compared with ranibizumab ( IVR ) in the treatment of macular oedema due to branch retinal vein occlusion ( BRVO ) .", "sentence_id": 0}
+{"abstract_id": "25631483", "label": "methods", "text": "In this prospective , randomised , non-inferiority trial , @ participants with macular oedema due to BRVO received intravitreal injections of ranibizumab or bevacizumab after @:@ block randomisation .", "sentence_id": 1}
+{"abstract_id": "25631483", "label": "methods", "text": "The primary outcome measure was the difference in mean changes in best-corrected visual acuity ( BCVA ) at @months .", "sentence_id": 2}
+{"abstract_id": "25631483", "label": "methods", "text": "Secondary outcome measures included mean change in central retinal thickness ( CRT ) , the proportion of patients improving by > @ letters and the proportion of patients developing neovascularisation .", "sentence_id": 3}
+{"abstract_id": "25631483", "label": "results", "text": "Participants received either IVR ( n = @ ) or IVB ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25631483", "label": "results", "text": "The mean BCVA at baseline was @ letters ( @/@ ) and @ letters ( @/@ ) ( p = @ ) in the ranibizumab and bevacizumab groups , respectively .", "sentence_id": 5}
+{"abstract_id": "25631483", "label": "results", "text": "At @months , the mean gains in BCVA were +@ letters ( p < @ ; @ % CI , +@ to +@ ) in the ranibizumab group and +@ letters ( p < @ ; @ % CI +@ to +@ ) in the bevacizumab group .", "sentence_id": 6}
+{"abstract_id": "25631483", "label": "results", "text": "The difference between the mean visual gains of the treated groups ( bevacizumab-ranibizumab ) was -@ letters ( @ % CI -@ to +@ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25631483", "label": "results", "text": "Mean reductions in CRT at @months were @ m in the ranibizumab group ( p < @ ) and @ m in the bevacizumab group ( p < @ ) , with no significant difference between the two groups ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25631483", "label": "results", "text": "The mean numbers of ranibizumab and bevacizumab injections were @ and @ , respectively ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25631483", "label": "results", "text": "Two serious adverse events occurred in the ranibizumab group and one in the bevacizumab group but both were unrelated to intravitreal injections .", "sentence_id": 10}
+{"abstract_id": "25631483", "label": "conclusions", "text": "This study demonstrated significant gain in visual acuity in eyes with BRVO treated with either bevacizumab or ranibizumab .", "sentence_id": 11}
+{"abstract_id": "25631483", "label": "conclusions", "text": "Pro-re-nata strategy was effective in maintaining the visual gain .", "sentence_id": 12}
+{"abstract_id": "25982801", "label": "background", "text": "To investigate the ability of the prostate genetic score ( PGS-@ ) , a germ-line biomarker of prostate cancer ( PCa ) risk , to categorize men participating in the Prostate , Lung , Colorectal and Ovarian ( PLCO ) Cancer Screening Trial .", "sentence_id": 0}
+{"abstract_id": "25982801", "label": "methods", "text": "We obtained the genetic data from the Cancer Genetic Markers of Susceptibility ( CGEMS ) , a nested case control study examining germ-line DNA in the screened arm of the PLCO trial .", "sentence_id": 1}
+{"abstract_id": "25982801", "label": "methods", "text": "A PGS-@ was calculated based on their genotype at @ PCa associated single nucleotide polymorphisms ( SNPs ) .", "sentence_id": 2}
+{"abstract_id": "25982801", "label": "methods", "text": "The primary outcome was the diagnosis of PCa and primary predictor was PGS-@ .", "sentence_id": 3}
+{"abstract_id": "25982801", "label": "results", "text": "We identified @,@ subjects ( no cancer , N = @ ) and cases ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "25982801", "label": "results", "text": "The PGS-@ ( P < @ ) , prostate specific antigen ( PSA ; P < @ ) , family history of PCa ( < @ ) , abnormal digital rectal exam ( DRE , P < @ ) , and history of ever smoking ( P = @ ) were associated with a PCa diagnosis .", "sentence_id": 5}
+{"abstract_id": "25982801", "label": "results", "text": "In multivariable analysis , the log ( PGS-@ ) was associated with PCa diagnosis with an odds ratio of @ ( @ % CI @-@ @ , P < @ ) , log ( PSA ) ( OR @ ; @ % CI @-@ @ , P < @ ) , and family history of PCa ( OR @ ; @ % CI @-@ @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25982801", "label": "results", "text": "PGS-@ quartiles noted an increasing rate of PCa detection in addition to PSA : @ % ( Q@ ) , @ % ( Q@ ) , @ % ( Q@ ) , and @ ( Q@ ) ( P < @ ) and improvement in PSA performance ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25982801", "label": "conclusions", "text": "Germ-line DNA in the form of the PGS-@ is able to risk stratify men regarding their risk of PCa .", "sentence_id": 8}
+{"abstract_id": "25982801", "label": "conclusions", "text": "The PGS-@ may have implications regarding who may benefit most from PCa screening and possibly add to PSA performance .", "sentence_id": 9}
+{"abstract_id": "25631224", "label": "background", "text": "Community-based health education programs may be helpful in improving health outcomes in patients with chronic illnesses .", "sentence_id": 0}
+{"abstract_id": "25631224", "label": "background", "text": "This study aimed to evaluate community-based health education strategies in the management of hypertensive patients with low socioeconomic status in Dongguan City , China .", "sentence_id": 1}
+{"abstract_id": "25631224", "label": "methods", "text": "This was a randomized , non-blinded trial involving @ hypertensive patients enrolled in the community health service centre of Liaobu Town , Dongguan City , China .", "sentence_id": 2}
+{"abstract_id": "25631224", "label": "methods", "text": "Participants were randomized to receive one of the three community-based health education programs over @ years : self-learning reading ( Group @ ) , monthly regular didactic lecture ( Group @ ) , monthly interactive education workshop ( Group @ ) .", "sentence_id": 3}
+{"abstract_id": "25631224", "label": "methods", "text": "Outcomes included the changes in the proportion of subjects with normalized blood pressure ( BP ) , hypertension-related knowledge score , adherence to antihypertensive treatment , lifestyle , body mass index and serum lipids .", "sentence_id": 4}
+{"abstract_id": "25631224", "label": "results", "text": "After the @-y intervention , the proportion of subjects with normalized BP increased significantly in Group @ ( from @ % to @ % , p < @ ) , and increased more substantially in Group @ ( from @ % to @ % , p < @ ) , but did not change significantly in Group @ .", "sentence_id": 5}
+{"abstract_id": "25631224", "label": "results", "text": "Improvements in hypertension-related knowledge score , adherence to regular use of medications , appropriate salt intake and regular physical activity were progressively greater from group @ to group @ to group @ .", "sentence_id": 6}
+{"abstract_id": "25631224", "label": "results", "text": "Group @ had the largest reductions in body mass index and serum LDL cholesterol levels .", "sentence_id": 7}
+{"abstract_id": "25631224", "label": "conclusions", "text": "Interactive education workshops may be the most effective strategy in community-based health promotion education programs for hypertensive patients in improving patients ' knowledge on hypertension and alleviating clinical risk factors for preventing hypertension-related complications .", "sentence_id": 8}
+{"abstract_id": "24525654", "label": "background", "text": "Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy .", "sentence_id": 0}
+{"abstract_id": "24525654", "label": "background", "text": "This study 's aim was to determine if treatment with sertraline ( SERT ) or SERT plus gabapentin ( GBP ) improved treatment retention , depressive symptoms , and/or cocaine use .", "sentence_id": 1}
+{"abstract_id": "24525654", "label": "methods", "text": "Depressed cocaine-dependent patients ( N = @ ) were enrolled in a @-week , double-blind , randomized , placebo ( PLA ) - controlled , clinical trial and placed in research beds at a residential treatment facility ( Recovery Centers of Arkansas ) .", "sentence_id": 2}
+{"abstract_id": "24525654", "label": "methods", "text": "They were randomized by depressive symptom severity and inducted onto @ of the following while residing at the Recovery Centers of Arkansas : SERT ( @ mg/d ) , SERT ( @ mg/d ) plus GBP ( @ mg/d ) , or PLA .", "sentence_id": 3}
+{"abstract_id": "24525654", "label": "methods", "text": "Participants transferred to outpatient treatment at the start of their third week , continued receiving study medications or PLA ( weeks @-@ ) , and participated in weekly individual cognitive behavioral therapy .", "sentence_id": 4}
+{"abstract_id": "24525654", "label": "methods", "text": "Compliance was facilitated through the use of contingency management procedures .", "sentence_id": 5}
+{"abstract_id": "24525654", "label": "methods", "text": "Supervised urine samples were obtained thrice weekly and self-reported mood weekly .", "sentence_id": 6}
+{"abstract_id": "24525654", "label": "methods", "text": "At the end of @ weeks , participants were tapered off the study medication over @ days and referred to a local treatment program .", "sentence_id": 7}
+{"abstract_id": "24525654", "label": "results", "text": "Sertraline , but not SERT plus GBP , showed a significantly lower overall percentage of cocaine-positive urine samples compared with that of PLA .", "sentence_id": 8}
+{"abstract_id": "24525654", "label": "results", "text": "A significantly greater percentage of participants experienced relapse in the PLA group ( @ % ) compared with that of the SERT group ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24525654", "label": "results", "text": "Hamilton depression ratings decreased significantly over time regardless of the treatment group .", "sentence_id": 10}
+{"abstract_id": "24525654", "label": "results", "text": "Retention in treatment did not differ significantly between the treatment groups .", "sentence_id": 11}
+{"abstract_id": "24525654", "label": "conclusions", "text": "Sertraline plus GBP may not be superior to SERT alone in delaying relapse among abstinent cocaine-dependent individuals undergoing cognitive behavioral therapy .", "sentence_id": 12}
+{"abstract_id": "25654961", "label": "objective", "text": "To evaluate and compare the efficacy of platelet-rich fibrin ( PRF ) with enamel matrix derivative ( EMD ; Emdogain ) in the treatment of periodontal intrabony defects in patients with chronic periodontitis , six months after surgery .", "sentence_id": 0}
+{"abstract_id": "25654961", "label": "methods", "text": "Forty-four ( @ ) intrabony defects in @ patients ( @ males ) were randomly allocated into two treatment groups : EMD ( n = @ ) and PRF ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25654961", "label": "methods", "text": "Measurement of the defects was done using clinical and cone beam computed tomography at baseline and @ months .", "sentence_id": 2}
+{"abstract_id": "25654961", "label": "methods", "text": "Clinical and radiographic parameters such as probing depth , clinical attachment level , intrabony defect depth and defect angle , were recorded at baseline and @ months post-operatively .", "sentence_id": 3}
+{"abstract_id": "25654961", "label": "methods", "text": "Within group change was evaluated using the Wilcoxon signed rank test .", "sentence_id": 4}
+{"abstract_id": "25654961", "label": "methods", "text": "Intergroup comparisons were made using the Mann-Whitney U test .", "sentence_id": 5}
+{"abstract_id": "25654961", "label": "results", "text": "Postsurgical measurements revealed that there was an equal reduction in probing depth and a greater but statistically non-significant attachment gain for the Emdogain group when compared to the platelet-rich fibrin group .", "sentence_id": 6}
+{"abstract_id": "25654961", "label": "results", "text": "The Emdogain group presented with significantly greater percentage defect resolution ( @ % @ ) than did the platelet-rich fibrin group ( @ % @ ) .", "sentence_id": 7}
+{"abstract_id": "25654961", "label": "results", "text": "Post-operatively the changes in defect width and defect angle were significant in both groups , but upon intergroup comparison they were found to be statistically non-significantly different .", "sentence_id": 8}
+{"abstract_id": "25654961", "label": "conclusions", "text": "Both Emdogain and platelet-rich fibrin were effective in the regeneration of intrabony defects .", "sentence_id": 9}
+{"abstract_id": "25654961", "label": "conclusions", "text": "Emdogain was significantly superior in terms of percentage defect resolution .", "sentence_id": 10}
+{"abstract_id": "24602137", "label": "objective", "text": "HM@ is a third generation P-glycoprotein ( P-gp ) inhibitor currently under development .", "sentence_id": 0}
+{"abstract_id": "24602137", "label": "objective", "text": "The objectives of this study were to evaluate the effects of a single dose of HM@ on the pharmacodynamics and pharmacokinetics of loperamide , a P-gp substrate , and to compare them with those of quinidine .", "sentence_id": 1}
+{"abstract_id": "24602137", "label": "methods", "text": "Eighteen healthy male subjects were administered loperamide alone ( period @ ) or with loperamide plus quinidine or HM@ in period @ or @ , respectively .", "sentence_id": 2}
+{"abstract_id": "24602137", "label": "methods", "text": "In period @ , subjects randomly received one of three HM@ doses : @ , @ or @mg .", "sentence_id": 3}
+{"abstract_id": "24602137", "label": "methods", "text": "Changes in pupil size , alertness , oxygen saturation and the oral bioavailability of loperamide were assessed in each period .", "sentence_id": 4}
+{"abstract_id": "24602137", "label": "methods", "text": "In addition , the pharmacokinetics of HM@ were determined .", "sentence_id": 5}
+{"abstract_id": "24602137", "label": "results", "text": "Pupil size , alertness and oxygen saturation did not change over time when loperamide alone or loperamide plus HM@ was administered while HM@ significantly increased the systemic exposure to loperamide , i.e. the geometric mean ratio ( @ % confidence interval ) of AUC ( @ , tlast ) for loperamide with and without HM@ was @ ( @ , @ ) .", "sentence_id": 6}
+{"abstract_id": "24602137", "label": "results", "text": "Co-administered quinidine significantly increased the systemic exposure to loperamide @-fold ( @ , @ ) , which also markedly reduced pupil size , resulting in a decrease of @ mmh in the area under the effect curve of pupil size change from baseline compared with loperamide alone .", "sentence_id": 7}
+{"abstract_id": "24602137", "label": "conclusions", "text": "HM@ inhibits P-gp mainly in the intestinal endothelium , which can be beneficial because pan-inhibition of P-gp , particularly in the brain , could lead to detrimental adverse events .", "sentence_id": 8}
+{"abstract_id": "24602137", "label": "conclusions", "text": "Further studies are warranted to investigate adequately the dose-exposure relationship of HM@ , along with its duration of effect .", "sentence_id": 9}
+{"abstract_id": "24643406", "label": "objective", "text": "Most stroke rehabilitation studies have been performed in high-income countries .", "sentence_id": 0}
+{"abstract_id": "24643406", "label": "objective", "text": "The aim of this study was to identify the main barriers for patient inclusion in a research protocol performed in Brazil .", "sentence_id": 1}
+{"abstract_id": "24643406", "label": "methods", "text": "We evaluated reasons for exclusion of patients in a pilot , randomized , double-blinded clinical trial of stroke rehabilitation .", "sentence_id": 2}
+{"abstract_id": "24643406", "label": "methods", "text": "Descriptive statistical analysis was performed .", "sentence_id": 3}
+{"abstract_id": "24643406", "label": "results", "text": "Only @ % of @ screened patients were included .", "sentence_id": 4}
+{"abstract_id": "24643406", "label": "results", "text": "Recurrent stroke was responsible for exclusion of @ % of potentially eligible patients .", "sentence_id": 5}
+{"abstract_id": "24643406", "label": "conclusions", "text": "Recurrent stroke represented a big barrier to enroll patients in the protocol .", "sentence_id": 6}
+{"abstract_id": "24643406", "label": "conclusions", "text": "External validity of rehabilitation trials will benefit from definition of study criteria according to regional characteristics of patients , including rates of recurrent stroke .", "sentence_id": 7}
+{"abstract_id": "24825641", "label": "objective", "text": "Patients with colorectal cancer with liver metastases undergo hepatic resection with curative intent .", "sentence_id": 0}
+{"abstract_id": "24825641", "label": "objective", "text": "Positron emission tomography combined with computed tomography ( PET-CT ) could help avoid noncurative surgery by identifying patients with occult metastases .", "sentence_id": 1}
+{"abstract_id": "24825641", "label": "objective", "text": "To determine the effect of preoperative PET-CT vs no PET-CT ( control ) on the surgical management of patients with resectable metastases and to investigate the effect of PET-CT on survival and the association between the standardized uptake value ( ratio of tissue radioactivity to injected radioactivity adjusted by weight ) and survival .", "sentence_id": 2}
+{"abstract_id": "24825641", "label": "methods", "text": "A randomized trial of patients older than @ years with colorectal cancer treated by surgery , with resectable metastases based on CT scans of the chest , abdomen , and pelvis within the previous @ days , and with a clear colonoscopy within the previous @ months was conducted between @ and @ , involving @ surgeons at @ hospitals in Ontario , Canada , with PET-CT scanners at @ academic institutions .", "sentence_id": 3}
+{"abstract_id": "24825641", "label": "methods", "text": "Patients were randomized using a @ to @ ratio to PET-CT or control .", "sentence_id": 4}
+{"abstract_id": "24825641", "label": "methods", "text": "The primary outcome was a change in surgical management defined as canceled hepatic surgery , more extensive hepatic surgery , or additional organ surgery based on the PET-CT .", "sentence_id": 5}
+{"abstract_id": "24825641", "label": "methods", "text": "Survival was a secondary outcome .", "sentence_id": 6}
+{"abstract_id": "24825641", "label": "results", "text": "Of the @ patients who underwent PET-CT , @ had a change in surgical management ( @ % ; @ % CI , @ % -@ % ) .", "sentence_id": 7}
+{"abstract_id": "24825641", "label": "results", "text": "Specifically , @ patients ( @ % ) did not undergo laparotomy , @ ( @ % ) had more extensive hepatic surgery , @ ( @ % ) had additional organ surgery ( @ of whom had hepatic resection ) , and the abdominal cavity was opened in @ patient but hepatic surgery was not performed and the cavity was closed .", "sentence_id": 8}
+{"abstract_id": "24825641", "label": "results", "text": "Liver resection was performed in @ % of patients in the PET-CT group and @ % of the control group .", "sentence_id": 9}
+{"abstract_id": "24825641", "label": "results", "text": "After a median follow-up of @ months , the estimated mortality rate was @ ( @ % CI , @-@ @ ) events/@ person-months for the PET-CT group and @ ( @ % CI , @-@ @ ) events/@ person-months for the control group .", "sentence_id": 10}
+{"abstract_id": "24825641", "label": "results", "text": "Survival did not differ between the @ groups ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24825641", "label": "results", "text": "The standardized uptake value was associated with survival ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- per unit increase ; P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24825641", "label": "results", "text": "The C statistic for the model including the standardized uptake value was @ ( @ % CI , @-@ @ ) and without it was @ ( @ % CI , @-@ @ ) .", "sentence_id": 13}
+{"abstract_id": "24825641", "label": "results", "text": "The difference in C statistics is @ ( @ % CI , @-@ @ ) .", "sentence_id": 14}
+{"abstract_id": "24825641", "label": "results", "text": "The low C statistic suggests that the standard uptake value is not a strong predictor of overall survival .", "sentence_id": 15}
+{"abstract_id": "24825641", "label": "conclusions", "text": "Among patients with potentially resectable hepatic metastases of colorectal adenocarcinoma , the use of PET-CT compared with CT alone did not result in frequent change in surgical management .", "sentence_id": 16}
+{"abstract_id": "24825641", "label": "conclusions", "text": "These findings raise questions about the value of PET-CT scans in this setting .", "sentence_id": 17}
+{"abstract_id": "24603072", "label": "objective", "text": "Intravenous recombinant tissue-type plasminogen activator ( r-tPA ) , despite a risk of early symptomatic intracranial hemorrhage ( sICH ) , is of net clinical benefit to acute stroke patients .", "sentence_id": 0}
+{"abstract_id": "24603072", "label": "objective", "text": "We tested if predictive models could identify patients least likely to be harmed by sICH or those who gained no net benefit .", "sentence_id": 1}
+{"abstract_id": "24603072", "label": "methods", "text": "We used the Third International Stroke Trial ( IST-@ ) trial data set , an international , multicenter , open treatment randomized trial of @ mg/kg r-tPA versus control in @ patients with acute ischemic stroke .", "sentence_id": 2}
+{"abstract_id": "24603072", "label": "methods", "text": "We compared the discrimination and calibration of previously developed predictive models for ICH and poststroke poor outcome and developed a new model using variables selected by systematic review .", "sentence_id": 3}
+{"abstract_id": "24603072", "label": "methods", "text": "We calculated the absolute and relative risk reduction of death or dependency with r-tPA in patients at a low , medium , or high predicted risk of sICH or poor functional outcome .", "sentence_id": 4}
+{"abstract_id": "24603072", "label": "results", "text": "Prediction models for sICH or poor outcome ( Hemorrhage After Thrombolysis -LSB- HAT -RSB- ; Sugar , Early Infarct Signs , Dense Artery , Age , National Institutes of Health ( NIH ) Stroke Score ( SEDAN ) ; Glucose Race Age Sex Pressure Stroke Severity -LSB- GRASPS -RSB- ; Stroke Thrombolytic Predictive Instrument ; Dense Artery , Rankin Score , Age , Glucose , Onset to Treatment Time , NIHSS -LSB- DRAGON -RSB- ; Totaled Health Risks in Vascular Events -LSB- THRIVE -RSB- ; our new model ; and a model with National Institutes of Health Stroke Scale and age ) had similar area under receiver operator characteristic curves ( AUROCC ) to predict sICH ( P for difference > @ ) .", "sentence_id": 5}
+{"abstract_id": "24603072", "label": "results", "text": "The simplest model ( with covariates National Institutes of Health Stroke Scale and age ) predicted both sICH ( AUROCC , @ ; @ % CI , @-@ @ ) and poststroke poor functional outcome ( AUROCC , @ ; @ % CI , @-@ @ ) similarly to complex models .", "sentence_id": 6}
+{"abstract_id": "24603072", "label": "results", "text": "There was no evidence that the effect of r-tPA in patients at high predicted risk of sICH or poor functional outcome after stroke was less than in those at lower risk .", "sentence_id": 7}
+{"abstract_id": "24603072", "label": "conclusions", "text": "There is a clinically relevant net positive effect of r-tPA in patients with acute stroke at a high predicted risk of sICH or poor functional outcome .", "sentence_id": 8}
+{"abstract_id": "24836474", "label": "background", "text": "We sought to determine whether the design of @ different double-lumen endobronchial tubes ( DLT ) ( Rusch , Mallinckrodt , Fuji ) has an effect on the ease of placement over an airway exchange catheter ( AEC ) using a video laryngoscope .", "sentence_id": 0}
+{"abstract_id": "24836474", "label": "methods", "text": "A convenience sample of @ anesthesia residents and fellows with at least @ years of anesthesia training was recruited from teaching hospitals in Toronto for a randomized crossover trial .", "sentence_id": 1}
+{"abstract_id": "24836474", "label": "methods", "text": "Each participant passed each DLT over an AEC in an airway simulator , visualized and video recorded via a video laryngoscope ( GlideScope ) .", "sentence_id": 2}
+{"abstract_id": "24836474", "label": "methods", "text": "The order of exchange was randomized by blindly pulling the name of the manufacturer of a DLT from a box .", "sentence_id": 3}
+{"abstract_id": "24836474", "label": "methods", "text": "The primary outcome was time to intubate , defined as time from the bronchial lumen entering the GlideScope view to the bronchial lumen passing the vocal cords .", "sentence_id": 4}
+{"abstract_id": "24836474", "label": "methods", "text": "Also recorded were participants ' subjective rating of the ease of use and failure rate , defined as an attempt > @-second duration .", "sentence_id": 5}
+{"abstract_id": "24836474", "label": "results", "text": "Time to intubate was faster with the Fuji-Phycon DLT ( median @ seconds ) compared with both the Rusch ( median @ seconds , P = @ ) and Mallinckrodt ( median @ seconds , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24836474", "label": "results", "text": "On a scale of @ to @ , with @ being very easy to use and @ being very difficult , the Fuji-Phycon was judged to be easier to use ( median @ seconds ) compared with the Rusch ( median @ , P = @ ) and the Mallinckrodt ( median @ seconds , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24836474", "label": "results", "text": "The Rusch was associated with significantly more failures than the other DLTs , P = @ .", "sentence_id": 8}
+{"abstract_id": "24836474", "label": "conclusions", "text": "The Fuji-Phycon DLT was easier to pass over an AEC in this simulator trial and warrants consideration in patients with difficult airways who require @-lung ventilation .", "sentence_id": 9}
+{"abstract_id": "24397879", "label": "objective", "text": "Acute kidney injury ( AKI ) after cardiac surgery procedures is associated with poor patient outcomes .", "sentence_id": 0}
+{"abstract_id": "24397879", "label": "objective", "text": "Cystatin C as a marker for renal failure has been shown to be of prognostic value ; however , a wide range of its predictive accuracy has been reported .", "sentence_id": 1}
+{"abstract_id": "24397879", "label": "objective", "text": "The aim of the study was to evaluate whether the measurement of pre - and postoperative serum cystatin C improves the prediction of AKI .", "sentence_id": 2}
+{"abstract_id": "24397879", "label": "methods", "text": "In a single-centre , prospective study of @ patients ( @ @ ys ; range @-@ ys ; @ % male ) , cystatin C was measured six times : ( T@ = preoperative , T@ = start cardiopulmonary bypass ( CPB ) , T@ = @ min after CPB , T@ = end of operation ; T@ = @ h postoperatively ; T@ = @d postoperatively ) .", "sentence_id": 3}
+{"abstract_id": "24397879", "label": "methods", "text": "Predictive property , in terms of the need for renal replacement therapy ( RRT ) , was analysed by receiver operating characteristics ( ROC ) statistics and described by the area under the curve ( AUC ) .", "sentence_id": 4}
+{"abstract_id": "24397879", "label": "results", "text": "With respect to RRT ( n = @ ) , serum cystatin C was significantly higher at the end of the operation ( T@ ) , @ h postoperatively at T@ and at T@ .", "sentence_id": 5}
+{"abstract_id": "24397879", "label": "results", "text": "The AUCs for preoperative T@ and intraoperative T@/@ cystatin C were < @ ( @ % CI , @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24397879", "label": "results", "text": "The earliest significant predictive AUCs were found at the end of the operation ( T@ : p = @ @ % CI @-@ @ AUC @ ) and @ h postoperatively ( T@ : p = @ @ % CI @-@ @ AUC @ ) .", "sentence_id": 7}
+{"abstract_id": "24397879", "label": "conclusions", "text": "Early postoperative serum cystatin C increase appears to be a moderate biomarker in the prediction of AKI , whereas a preoperative and intraoperative cystatin C increase has only a limited diagnostic and predictive value .", "sentence_id": 8}
+{"abstract_id": "25243647", "label": "objective", "text": "To examine whether @ weeks of treatment with a dipeptidyl peptidase-@ ( DPP-@ ) inhibitor , sitagliptin , influences the insulin secretion induced by glucose , glucose-dependent insulinotropic polypeptide ( GIP ) and glucagon-like peptide-@ ( GLP-@ ) during a hyperglycaemic clamp in patients with type @ diabetes ( T@DM ) .", "sentence_id": 0}
+{"abstract_id": "25243647", "label": "methods", "text": "A randomized , double-blind , placebo-controlled study was conducted over @ weeks , during which @ patients with T@DM completed treatment with either sitagliptin ( @mg once daily ) or placebo as add-on therapy to metformin -LSB- sitagliptin group ( n = @ ) : meanstandard error of the mean ( s.e.m. ) age @ years , means.e.m .", "sentence_id": 1}
+{"abstract_id": "25243647", "label": "methods", "text": "HbA@c @ % ; placebo group ( n = @ ) : means.e.m .", "sentence_id": 2}
+{"abstract_id": "25243647", "label": "methods", "text": "age : @ years , means.e.m .", "sentence_id": 3}
+{"abstract_id": "25243647", "label": "methods", "text": "HbA@c @ % -RSB- .", "sentence_id": 4}
+{"abstract_id": "25243647", "label": "methods", "text": "In weeks @ and @ , the patients underwent three @-h @-mM hyperglycaemic clamp experiments with infusion of either saline , GLP-@ or GIP .", "sentence_id": 5}
+{"abstract_id": "25243647", "label": "methods", "text": "- cell function was evaluated according to first-phase , second-phase , incremental and total insulin and C-peptide responses .", "sentence_id": 6}
+{"abstract_id": "25243647", "label": "results", "text": "In the sitagliptin group , the mean HbA@c concentration was significantly reduced by @ % ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25243647", "label": "results", "text": "The total - cell response during GIP infusion improved significantly from week @ to week @ , both within the sitagliptin group ( p = @ ) and when compared with the placebo group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25243647", "label": "results", "text": "The total - cell response during GLP-@ infusion was significantly higher ( p = @ ) when compared with saline and GIP infusion , but with no improvement from week @ to week @ .", "sentence_id": 9}
+{"abstract_id": "25243647", "label": "results", "text": "No significant changes in - cell function occurred in the placebo group .", "sentence_id": 10}
+{"abstract_id": "25243647", "label": "conclusions", "text": "Treatment with the DPP-@ inhibitor sitagliptin over @ weeks in patients with T@DM partially restored the lost insulinotropic effect of GIP , whereas the preserved insulinotropic effect of GLP-@ was not further improved .", "sentence_id": 11}
+{"abstract_id": "25243647", "label": "conclusions", "text": "A gradual enhancement of the insulinotropic effect of GIP , therefore , possibly contributes to the antidiabetic actions of DPP-@ inhibitors .", "sentence_id": 12}
+{"abstract_id": "25610500", "label": "objective", "text": "Fluticasone and formoterol are effective in the treatment of asthma .", "sentence_id": 0}
+{"abstract_id": "25610500", "label": "objective", "text": "When a corticosteroid alone fails to control asthma , combination therapy is the treatment of choice .", "sentence_id": 1}
+{"abstract_id": "25610500", "label": "objective", "text": "The objective of this study was to compare the efficacy and safety of formulations containing budesonide/formoterol ( BUD/FOR ) , fluticasone alone ( FLU ) , and the single-capsule combination of fluticasone/formoterol ( FLU/FOR ) on lung function in patients with mild-to-moderate persistent asthma .", "sentence_id": 2}
+{"abstract_id": "25610500", "label": "methods", "text": "This was a randomized , multicenter , open phase III trial conducted in Brazil .", "sentence_id": 3}
+{"abstract_id": "25610500", "label": "methods", "text": "The primary efficacy analysis was the assessment of non-inferiority between FLU/FOR and BUD/FOR combinations regarding FEV@ ( in L ) at the final visit .", "sentence_id": 4}
+{"abstract_id": "25610500", "label": "methods", "text": "The secondary analyses were PEF , level of asthma control , serum cortisol levels , frequency of adverse events , adherence to treatment , and appropriate inhaler use .", "sentence_id": 5}
+{"abstract_id": "25610500", "label": "results", "text": "We randomized @ patients to three groups : FLU/FOR ( n = @ ) , BUD/FOR ( n = @ ) , and FLU ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "25610500", "label": "results", "text": "In terms of the mean FEV@ after @ weeks of treatment , the difference between the FLU/FOR and BUD/FOR groups was @ L ( @ % CI : -@ to @ ) , whereas the difference between the FLU/FOR and FLU groups was @ L ( @ % CI : -@ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25610500", "label": "results", "text": "Non-inferiority was demonstrated by the difference between the lower limits of the two @ % CIs ( -@ vs. -@ ) .", "sentence_id": 8}
+{"abstract_id": "25610500", "label": "results", "text": "The level of asthma control and PEF were significantly greater in the FLU/FOR and BUD/FOR groups than in the FLU group .", "sentence_id": 9}
+{"abstract_id": "25610500", "label": "results", "text": "There were no significant differences among the groups regarding patient adherence , patient inhaler use , or safety profile of the formulations .", "sentence_id": 10}
+{"abstract_id": "25610500", "label": "conclusions", "text": "The single-capsule combination of FLU/FOR showed non-inferiority to the BUD/FOR and FLU formulations regarding efficacy and safety , making it a new treatment option for persistent asthma .", "sentence_id": 11}
+{"abstract_id": "24692475", "label": "objective", "text": "Atrial fibrillation is associated with decline of cognitive function .", "sentence_id": 0}
+{"abstract_id": "24692475", "label": "objective", "text": "Observational evidence suggests that anticoagulation might protect against this decline .", "sentence_id": 1}
+{"abstract_id": "24692475", "label": "objective", "text": "We report the first randomized controlled trial evidence on the effect of anticoagulation on cognitive function in elderly patients with atrial fibrillation .", "sentence_id": 2}
+{"abstract_id": "24692475", "label": "methods", "text": "A total of @ patients aged@ years with atrial fibrillation were recruited from primary care and randomly assigned to warfarin ( n = @ ; target international normalized ratio , @-@ ) or aspirin ( n = @ ; @ mg/d ) .", "sentence_id": 3}
+{"abstract_id": "24692475", "label": "methods", "text": "Neither participants nor investigators were masked to group assignment .", "sentence_id": 4}
+{"abstract_id": "24692475", "label": "methods", "text": "Follow-up was for a mean of @ years ( SD , @ ) .", "sentence_id": 5}
+{"abstract_id": "24692475", "label": "methods", "text": "Cognitive outcome was assessed using the Mini-Mental State Examination at @ - , @ - , and @-month follow-up .", "sentence_id": 6}
+{"abstract_id": "24692475", "label": "methods", "text": "Participants who had a stroke were censored from the analysis , which was by intention to treat with imputation for missing data .", "sentence_id": 7}
+{"abstract_id": "24692475", "label": "results", "text": "There was no difference between mean Mini-Mental State Examination scores in people assigned to warfarin or aspirin at @ or @ months .", "sentence_id": 8}
+{"abstract_id": "24692475", "label": "results", "text": "At @-month follow-up , there was a nonsignificant difference of @ in favor of warfarin that decreased to @ ( @ % confidence interval , -@ to @ ) after imputation .", "sentence_id": 9}
+{"abstract_id": "24692475", "label": "conclusions", "text": "We found no evidence that anticoagulation confers clinically important protection over aspirin against cognitive decline as measured by the Mini-Mental State Examination in atrial fibrillation in the first @ months of treatment other than that provided by preventing clinical stroke .", "sentence_id": 10}
+{"abstract_id": "24912901", "label": "objective", "text": "The aim of this study was to identify the effects of a communication skills training ( CST ) program for oncologists , developed based on patient preferences regarding oncologists ' communication .", "sentence_id": 0}
+{"abstract_id": "24912901", "label": "methods", "text": "Thirty oncologists were randomly assigned to either an intervention group ( IG ; @-day CST workshop ) or control group ( CG ) .", "sentence_id": 1}
+{"abstract_id": "24912901", "label": "methods", "text": "Participants were assessed on their communication performance during simulated consultation and their confidence in communicating with patients at baseline and follow-up .", "sentence_id": 2}
+{"abstract_id": "24912901", "label": "methods", "text": "A total of @,@ patients ( response rate , @ % ) who had consultations with the participating oncologists at baseline and/or follow-up were assessed regarding their distress using the Hospital Anxiety and Depression Scale , satisfaction with the consultation , and trust in their oncologist after the consultation .", "sentence_id": 3}
+{"abstract_id": "24912901", "label": "results", "text": "At the follow-up survey , the performance scores of the IG had improved significantly , in terms of their emotional support ( P = @ ) , setting up a supportive environment ( P = @ ) , and ability to deliver information ( P = @ ) , compared with those of the CG .", "sentence_id": 4}
+{"abstract_id": "24912901", "label": "results", "text": "Oncologists in the IG were rated higher at follow-up than those in the CG in terms of their confidence in themselves ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24912901", "label": "results", "text": "Patients who met with oncologists after they had undergone the CST were significantly less depressed than those who met with oncologists in the CG ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24912901", "label": "results", "text": "However , the CST program did not affect patient satisfaction with oncologists ' style of communication .", "sentence_id": 7}
+{"abstract_id": "24912901", "label": "conclusions", "text": "A CST program based on patient preferences is effective for both oncologists and patients with cancer .", "sentence_id": 8}
+{"abstract_id": "24912901", "label": "conclusions", "text": "Oncologists should consider CST as an approach to enhancing their communication skills .", "sentence_id": 9}
+{"abstract_id": "24342386", "label": "objective", "text": "Attention bias modification treatment ( ABMT ) is a promising novel treatment for anxiety disorders , but clinical trials have focused largely on stand-alone formats among adults .", "sentence_id": 0}
+{"abstract_id": "24342386", "label": "objective", "text": "This randomized controlled trial examined the augmenting effects of threat-based ABMT on cognitive behavioral therapy ( CBT ) in clinically anxious youth .", "sentence_id": 1}
+{"abstract_id": "24342386", "label": "methods", "text": "Sixty-three treatment-seeking children with anxiety disorder were randomly assigned to @ of the following @ treatment groups : ABMT + CBT ; ABMT placebo + CBT ; and CBT-alone .", "sentence_id": 2}
+{"abstract_id": "24342386", "label": "methods", "text": "Participants in the @ ABMT conditions received repeated training on dot-probe tasks either designed to shift attention away from threats ( active ) or designed to induce no changes in attention patterns ( placebo ) .", "sentence_id": 3}
+{"abstract_id": "24342386", "label": "methods", "text": "Primary outcome measures were frequency and severity of anxiety symptoms as determined by a clinician using a semi-structured interview .", "sentence_id": 4}
+{"abstract_id": "24342386", "label": "methods", "text": "Self - and parent-rated anxiety measures and threat-related attention bias scores were also measured before and after treatment .", "sentence_id": 5}
+{"abstract_id": "24342386", "label": "results", "text": "Both the active and placebo ABMT groups showed greater reductions in clinician-rated anxiety symptoms than the CBT-alone group .", "sentence_id": 6}
+{"abstract_id": "24342386", "label": "results", "text": "Furthermore , only the active ABMT group showed significant reduction in self - or parent-rated anxiety symptoms .", "sentence_id": 7}
+{"abstract_id": "24342386", "label": "results", "text": "Finally , all groups showed a shift in attention patterns across the study , starting with a bias toward threat at baseline and shifting attention away from threat after treatment .", "sentence_id": 8}
+{"abstract_id": "24342386", "label": "conclusions", "text": "Active and placebo ABMT might augment the clinical response to CBT for anxiety .", "sentence_id": 9}
+{"abstract_id": "24342386", "label": "conclusions", "text": "This effect could arise from benefits associated with performing computer-based paradigms such as the dot-probe task .", "sentence_id": 10}
+{"abstract_id": "24342386", "label": "conclusions", "text": "Given the absence of group differences in attention-bias changes during treatment , possible mechanisms and methodological issues underlying the observed findings are discussed .", "sentence_id": 11}
+{"abstract_id": "24342386", "label": "conclusions", "text": "Clinical trial registration information-Augmenting Effects of ABMT on CBT in Anxious Children : A Randomized Clinical Trial ; http://clinicaltrials.gov/; NCT@ .", "sentence_id": 12}
+{"abstract_id": "25525278", "label": "objective", "text": "To analyze the effect of psychological intervention on reducing performance anxiety and the consequences of the intervention on first-year pharmacy students .", "sentence_id": 0}
+{"abstract_id": "25525278", "label": "methods", "text": "In this experimental study , @ first-year undergraduate pharmacy students from a private university in Malaysia were approached between weeks @ and @ of their first semester to participate in the study .", "sentence_id": 1}
+{"abstract_id": "25525278", "label": "methods", "text": "The completed responses for the Westside Test Anxiety Scale ( WTAS ) , the Kessler Perceived Distress Scale ( PDS ) , and the Academic Motivation Scale ( AMS ) were received from @ students .", "sentence_id": 2}
+{"abstract_id": "25525278", "label": "methods", "text": "Out of @ students , @ exhibited moderate to high test anxiety according to the WTAS ( score ranging from @ to @ ) and were randomly placed into either an experiment group ( n = @ ) or a waiting list control group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25525278", "label": "results", "text": "The prevalence of test anxiety among pharmacy students in this study was lower compared to other university students in previous studies .", "sentence_id": 4}
+{"abstract_id": "25525278", "label": "results", "text": "The present study 's anxiety management of psychoeducation and systematic education for test anxiety reduced lack of motivation and psychological distress and improved grade point average ( GPA ) .", "sentence_id": 5}
+{"abstract_id": "25525278", "label": "conclusions", "text": "Psychological intervention helped significantly reduce scores of test anxiety , psychological distress , and lack of motivation , and it helped improve students ' GPA .", "sentence_id": 6}
+{"abstract_id": "25882396", "label": "background", "text": "Treatment for patients with chronic lymphocytic leukaemia who are elderly or who have comorbidities is challenging because fludarabine-based chemoimmunotherapies are mostly not suitable .", "sentence_id": 0}
+{"abstract_id": "25882396", "label": "background", "text": "Chlorambucil remains the standard of care in many countries .", "sentence_id": 1}
+{"abstract_id": "25882396", "label": "background", "text": "We aimed to investigate whether the addition of ofatumumab to chlorambucil could lead to better clinical outcomes than does treatment with chlorambucil alone , while also being tolerable for patients who have few treatment options .", "sentence_id": 2}
+{"abstract_id": "25882396", "label": "methods", "text": "We carried out a randomised , open-label , phase @ trial for treatment-naive patients with chronic lymphocytic leukaemia in @ centres in @ countries .", "sentence_id": 3}
+{"abstract_id": "25882396", "label": "methods", "text": "We included patients who had active disease needing treatment , but in whom fludarabine-based treatment was not possible .", "sentence_id": 4}
+{"abstract_id": "25882396", "label": "methods", "text": "We randomly assigned patients ( @:@ ) to receive oral chlorambucil ( @ mg/m ( @ ) ) on days @-@ of a @ day treatment course or to receive chlorambucil by this schedule plus intravenous ofatumumab ( cycle @ : @ mg on day @ and @ mg on day @ ; subsequent cycles : @ mg on day @ ) for three to @ cycles .", "sentence_id": 5}
+{"abstract_id": "25882396", "label": "methods", "text": "Assignment was done with a randomisation list that was computer generated at GlaxoSmithKline , and was stratified , in a block size of two , by age , disease stage , and performance status .", "sentence_id": 6}
+{"abstract_id": "25882396", "label": "methods", "text": "The primary endpoint was progression-free survival in the intention-to-treat population and assessment was done by an independent review committee that was masked to group assignment .", "sentence_id": 7}
+{"abstract_id": "25882396", "label": "methods", "text": "The study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "25882396", "label": "results", "text": "We enrolled @ patients , median age @ years ( range @-@ ) .", "sentence_id": 9}
+{"abstract_id": "25882396", "label": "results", "text": "Between Dec @ , @ , and May @ , @ , we randomly assigned @ patients to chlorambucil plus ofatumumab and @ patients to chlorambucil alone .", "sentence_id": 10}
+{"abstract_id": "25882396", "label": "results", "text": "Median progression-free survival was @ months ( @ % CI @-@ ) in the group assigned to chlorambucil plus ofatumumab compared with @ months ( @-@ ) in the group assigned to chlorambucil only ( hazard ratio @ , @ % CI @-@ ; p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25882396", "label": "results", "text": "Grade @ or greater adverse events were more common in the chlorambucil plus ofatumumab group ( @ -LSB- @ % -RSB- patients ; vs @ -LSB- @ % -RSB- given chlorambucil alone ) , with neutropenia being the most common event ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "25882396", "label": "results", "text": "Grade @ or greater infections had similar frequency in both groups .", "sentence_id": 13}
+{"abstract_id": "25882396", "label": "results", "text": "Grade @ or greater infusion-related adverse events were reported in @ ( @ % ) patients given chlorambucil plus ofatumumab .", "sentence_id": 14}
+{"abstract_id": "25882396", "label": "results", "text": "Five ( @ % ) patients died during treatment in each group .", "sentence_id": 15}
+{"abstract_id": "25882396", "label": "conclusions", "text": "Addition of ofatumumab to chlorambucil led to clinically important improvements with a manageable side-effect profile in treatment-naive patients with chronic lymphocytic leukaemia who were elderly or had comorbidities .", "sentence_id": 16}
+{"abstract_id": "25882396", "label": "conclusions", "text": "Chlorambucil plus ofatumumab is therefore an important treatment option for these patients who can not tolerate more intensive therapy .", "sentence_id": 17}
+{"abstract_id": "24898304", "label": "objective", "text": "To compare the efficacy and safety of weekly albiglutide with daily sitagliptin , daily glimepiride , and placebo .", "sentence_id": 0}
+{"abstract_id": "24898304", "label": "methods", "text": "Patients with type @ diabetes receiving metformin were randomized to albiglutide ( @ mg ) , sitagliptin ( @ mg ) , glimepiride ( @ mg ) , or placebo .", "sentence_id": 1}
+{"abstract_id": "24898304", "label": "methods", "text": "Blinded dose titration for albiglutide ( to @ mg ) and glimepiride ( to @ mg ) was based on predefined hyperglycemia criteria .", "sentence_id": 2}
+{"abstract_id": "24898304", "label": "methods", "text": "The primary end point was change in HbA@c from baseline at week @ .", "sentence_id": 3}
+{"abstract_id": "24898304", "label": "methods", "text": "Secondary end points included fasting plasma glucose ( FPG ) , weight , and time to hyperglycemic rescue .", "sentence_id": 4}
+{"abstract_id": "24898304", "label": "results", "text": "Baseline characteristics were similar among the albiglutide ( n = @ ) , glimepiride ( n = @ ) , sitagliptin ( n = @ ) , and placebo ( n = @ ) groups .", "sentence_id": 5}
+{"abstract_id": "24898304", "label": "results", "text": "Baseline HbA@c was @ % ( @ mmol/mol ) ; mean age was @ years .", "sentence_id": 6}
+{"abstract_id": "24898304", "label": "results", "text": "The mean doses for albiglutide and glimepiride at week @ were @ and @ mg , respectively .", "sentence_id": 7}
+{"abstract_id": "24898304", "label": "results", "text": "At week @ , albiglutide significantly reduced HbA@c compared with placebo ( -@ % -LSB- -@ mmol/mol -RSB- ; P < @ ) , sitagliptin ( -@ % -LSB- -@ mmol/mol -RSB- ; P = @ ) , and glimepiride ( -@ % -LSB- -@ mmol/mol -RSB- ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24898304", "label": "results", "text": "Outcomes for FPG and HbA@c were similar .", "sentence_id": 9}
+{"abstract_id": "24898304", "label": "results", "text": "Weight change from baseline for each were as follows : albiglutide -@ kg ( @ % CI -@ to -@ ) , placebo -@ kg ( @ % CI -@ to -@ ) , sitagliptin -@ kg ( @ % CI -@ to -@ ) , glimepiride @ kg ( @ % CI @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24898304", "label": "results", "text": "The difference between albiglutide and glimepiride was statistically significant ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24898304", "label": "results", "text": "Hyperglycemic rescue rate at week @ was @ % for albiglutide compared with @ % ( P < @ ) , @ % ( P = @ ) , and @ % ( P = @ ) for placebo , sitagliptin , and glimepiride , respectively .", "sentence_id": 12}
+{"abstract_id": "24898304", "label": "results", "text": "Rates of serious adverse events in the albiglutide group were similar to comparison groups .", "sentence_id": 13}
+{"abstract_id": "24898304", "label": "results", "text": "Diarrhea ( albiglutide @ % , other groups @-@ @ % ) and nausea ( albiglutide @ % , other groups @-@ @ % ) were generally the most frequently reported gastrointestinal events .", "sentence_id": 14}
+{"abstract_id": "24898304", "label": "conclusions", "text": "Added to metformin , albiglutide was well tolerated ; produced superior reductions in HbA@c and FPG at week @ compared with placebo , sitagliptin , and glimepiride ; and resulted in weight loss compared with glimepiride .", "sentence_id": 15}
+{"abstract_id": "25363127", "label": "background", "text": "Despite a favorable clinical experience , little evidence exists for the efficacy of greater occipital nerve block ( GONB ) in migraine treatment .", "sentence_id": 0}
+{"abstract_id": "25363127", "label": "background", "text": "Considering such a premise , we wished to evaluate the therapeutic efficacy of GONB in patients affected by migraine headaches .", "sentence_id": 1}
+{"abstract_id": "25363127", "label": "methods", "text": "A randomized double-blinded controlled trial was conducted on @ patients suffering from migraine headaches .", "sentence_id": 2}
+{"abstract_id": "25363127", "label": "methods", "text": "A syringe containing @ mL of lidocaine @ % , @ mL of either saline ( control group , N = @ ) or triamcinolone @ mL ( intervention group , N = @ ) was prepared for each patient .", "sentence_id": 3}
+{"abstract_id": "25363127", "label": "methods", "text": "Patients were assessed prior to the injection , and also @ weeks , @ month , and @ months thereafter for severity and frequency of pain , times to use analgesics and any appeared side effects .", "sentence_id": 4}
+{"abstract_id": "25363127", "label": "results", "text": "No significant differences were revealed in pain severity , pain frequency , and analgesics use between the two groups at the four study time points including at baseline , and @ , @ , and @ weeks after the intervention .", "sentence_id": 5}
+{"abstract_id": "25363127", "label": "results", "text": "However , in both groups , the indices of pain severity , pain frequency , and analgesics use were significantly reduced at the three time points after the intervention compared with before the intervention .", "sentence_id": 6}
+{"abstract_id": "25363127", "label": "conclusions", "text": "GONB with triamcinolone in combination with lidocaine or normal saline with lidocaine results in reducing pain severity and frequency as well as use of analgesics up to two months after the intervention , however any difference attributed to the drug regimens by assessing of the trend of pain characteristics changes .", "sentence_id": 7}
+{"abstract_id": "24515619", "label": "objective", "text": "The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery .", "sentence_id": 0}
+{"abstract_id": "24515619", "label": "methods", "text": "A total of @ parturient women scheduled for elective caesarean sections were randomly assigned to two groups .", "sentence_id": 1}
+{"abstract_id": "24515619", "label": "methods", "text": "Five minutes before spinal anesthesia , Group O patients were injected with @ mg of ondansetron , while Group S patients were injected with @ mL physiological saline .", "sentence_id": 2}
+{"abstract_id": "24515619", "label": "methods", "text": "Maternal blood pressure and heart rate were measured at @ minute intervals for @ minutes .", "sentence_id": 3}
+{"abstract_id": "24515619", "label": "methods", "text": "After delivery , umbilical cord blood samples were analyzed .", "sentence_id": 4}
+{"abstract_id": "24515619", "label": "results", "text": "Maternal hypotension and nausea were significantly lower in ondansetron-treated patients versus placebo ( p = @ vs. @ ) .", "sentence_id": 5}
+{"abstract_id": "24515619", "label": "results", "text": "Umbilical venous pH was significantly higher in ondansetron-treated patients ( p = @ ) , while partial pressure of carbon dioxide ( Pco @ ) was significantly lower ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24515619", "label": "results", "text": "Decreases in maternal systolic and mean arterial blood pressures were significantly lower in ondansetron-treated patients ( p = @ vs. @ ) , with less requirement for phenylephrine administration compared with controls ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24515619", "label": "conclusions", "text": "Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea , while improving acid-base status , as well as reducing vasoconstrictor use .", "sentence_id": 8}
+{"abstract_id": "25332466", "label": "background", "text": "The common bean is a staple crop in many African and Latin American countries and is the focus of biofortification initiatives .", "sentence_id": 0}
+{"abstract_id": "25332466", "label": "background", "text": "Bean iron concentration has been doubled by selective plant breeding , but the additional iron is reported to be of low bioavailability , most likely due to high phytic acid ( PA ) concentrations .", "sentence_id": 1}
+{"abstract_id": "25332466", "label": "objective", "text": "The present study evaluated the impact of PA on iron bioavailability from iron-biofortified beans .", "sentence_id": 2}
+{"abstract_id": "25332466", "label": "methods", "text": "Iron absorption , based on erythrocyte incorporation of stable iron isotopes , was measured in @ Rwandese women who consumed multiple , composite bean meals with potatoes or rice in a crossover design .", "sentence_id": 3}
+{"abstract_id": "25332466", "label": "methods", "text": "Iron absorption from meals containing biofortified beans ( @ mg Fe , @ mg PA/@ g ) and control beans ( @ mg Fe , @ mg PA/@ g ) was measured with beans containing either their native PA concentration or with beans that were @ % dephytinized or > @ % dephytinized .", "sentence_id": 4}
+{"abstract_id": "25332466", "label": "results", "text": "The iron concentration of the cooked composite meals with biofortified beans was @ % higher than in the same meals with control beans .", "sentence_id": 5}
+{"abstract_id": "25332466", "label": "results", "text": "With native PA concentrations , fractional iron absorption from the control bean meals was @ % , @ % higher than that from the biofortified bean meals ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25332466", "label": "results", "text": "The quantity of iron absorbed from the biofortified bean meals ( @ g ) was @ % higher ( P < @ ) than that from the control bean meals .", "sentence_id": 7}
+{"abstract_id": "25332466", "label": "results", "text": "With @ % and > @ % dephytinization , the quantity of iron absorbed from the biofortified bean meals increased to @ and @ g , respectively , which was @ % ( P < @ ) and @ % ( P < @ ) higher than from the control bean meals .", "sentence_id": 8}
+{"abstract_id": "25332466", "label": "conclusions", "text": "PA strongly decreases iron bioavailability from iron-biofortified beans , and a high PA concentration is an important impediment to the optimal effectiveness of bean iron biofortification .", "sentence_id": 9}
+{"abstract_id": "25332466", "label": "conclusions", "text": "Plant breeders should focus on lowering the PA concentration of high-iron beans .", "sentence_id": 10}
+{"abstract_id": "25332466", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 11}
+{"abstract_id": "24880843", "label": "background", "text": "The exact force systems as well as their progressions generated by removable thermoplastic appliances have not been investigated .", "sentence_id": 0}
+{"abstract_id": "24880843", "label": "background", "text": "Thus , the purposes of this experimental study were to quantify the forces and moments delivered by a single aligner and a series of aligners ( Invisalign ; Align Technology , Santa Clara , Calif ) and to investigate the influence of attachments and power ridges on the force transfer .", "sentence_id": 1}
+{"abstract_id": "24880843", "label": "methods", "text": "We studied @ aligners of the Invisalign system ( @ series of aligners ) .", "sentence_id": 2}
+{"abstract_id": "24880843", "label": "methods", "text": "The aligners came from @ consecutive patients , of which @ tooth movements ( incisor torque , premolar derotation , molar distalization ) with @ movements each were analyzed .", "sentence_id": 3}
+{"abstract_id": "24880843", "label": "methods", "text": "The @ movement groups were subdivided so that @ movements were supported with an attachment and @ were not .", "sentence_id": 4}
+{"abstract_id": "24880843", "label": "methods", "text": "The patients ' ClinCheck ( Align Technology , Santa Clara , Calif ) was planned so that the movements to be investigated were performed in isolation in the respective quadrant .", "sentence_id": 5}
+{"abstract_id": "24880843", "label": "methods", "text": "Resin replicas of the patients ' intraoral situation before the start of the investigated movement were taken and mounted in a biomechanical measurement system .", "sentence_id": 6}
+{"abstract_id": "24880843", "label": "methods", "text": "An aligner was put on the model , the force systems were measured , and the calculated movements were experimentally performed until no further forces or moments were generated .", "sentence_id": 7}
+{"abstract_id": "24880843", "label": "methods", "text": "Subsequently , the next aligners were installed , and the measurements were repeated .", "sentence_id": 8}
+{"abstract_id": "24880843", "label": "results", "text": "The initial mean moments were about @ Nmm for maxillary incisor torque and about @ N for distalization .", "sentence_id": 9}
+{"abstract_id": "24880843", "label": "results", "text": "Significant differences in the generated moments were measured in the premolar derotation group , whether they were supported with an attachment ( @ Nmm ) or not ( @ Nmm ) .", "sentence_id": 10}
+{"abstract_id": "24880843", "label": "results", "text": "All measurements showed an exponential force change .", "sentence_id": 11}
+{"abstract_id": "24880843", "label": "conclusions", "text": "Apart from a few maximal initial force systems , the forces and moments generated by aligners of the Invisalign system are within the range of orthodontic forces .", "sentence_id": 12}
+{"abstract_id": "24880843", "label": "conclusions", "text": "The force change is exponential while a patient is wearing removable thermoplastic appliances .", "sentence_id": 13}
+{"abstract_id": "24937024", "label": "objective", "text": "This study aims to evaluate the treatment effects of physical exercise on menopausal symptoms in middle-aged female medical staff experiencing perimenopausal syndrome .", "sentence_id": 0}
+{"abstract_id": "24937024", "label": "methods", "text": "A total of @ female medical staff aged @ to @ years and with a Kupperman index score of @ points or higher were randomized @:@ into an intervention group ( n = @ ) or a control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24937024", "label": "methods", "text": "Women in the intervention group were asked to perform aerobic physical exercise ( walking with strides ) three times a week or more , whereas those in the control group continued as normal .", "sentence_id": 2}
+{"abstract_id": "24937024", "label": "methods", "text": "Measurements were taken at baseline and on weeks @ , @ , and @ , with total Kupperman index score , scores on individual elements of the scale , weight , and waist circumference recorded .", "sentence_id": 3}
+{"abstract_id": "24937024", "label": "methods", "text": "In addition , fasting blood glucose , triglycerides , total cholesterol , high-density lipoprotein cholesterol , and low-density lipoprotein cholesterol were recorded at baseline and on week @ .", "sentence_id": 4}
+{"abstract_id": "24937024", "label": "methods", "text": "The effects of physical exercise therapy on perimenopausal syndrome were evaluated by comparing changes in these parameters between the control group and the intervention group .", "sentence_id": 5}
+{"abstract_id": "24937024", "label": "results", "text": "Fifty-four and @ women completed all three follow-ups in the intervention and control groups , respectively .", "sentence_id": 6}
+{"abstract_id": "24937024", "label": "results", "text": "On week @ , the mean ( SD ) change in total Kupperman index score ( -@ -LSB- @ -RSB- ) from baseline to week @ ; the mean ( SD ) changes in individual scores for paresthesia ( -@ -LSB- @ -RSB- ) , insomnia ( -@ -LSB- @ -RSB- ) , irritability ( -@ -LSB- @ -RSB- ) , joint or muscle pain ( -@ -LSB- @ -RSB- ) , fatigue ( -@ -LSB- @ -RSB- ) , headache ( -@ -LSB- @ -RSB- ) , formication ( -@ -LSB- @ -RSB- ) , and sexual life ( -@ -LSB- @ -RSB- ) ; and the mean ( SD ) changes in total cholesterol ( -@ -LSB- @ -RSB- mmol/L ) and triglycerides ( -@ -LSB- @ -RSB- mmol/L ) were significantly higher in the intervention group than in the control group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24937024", "label": "results", "text": "In the intervention group , total Kupperman index score , weight , body mass index , waist circumference , triglycerides , and total cholesterol were significantly lower on week @ compared with baseline ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24937024", "label": "conclusions", "text": "Physical exercise can substantially reduce menopausal symptoms and improve blood lipid status and body weight .", "sentence_id": 9}
+{"abstract_id": "24550202", "label": "background", "text": "In-hospital cardiac arrest ( IHCA ) outcomes vary widely between hospitals , even after adjusting for patient characteristics , suggesting variations in practice as a potential etiology .", "sentence_id": 0}
+{"abstract_id": "24550202", "label": "background", "text": "However , little is known about the standards of IHCA resuscitation practice among US hospitals .", "sentence_id": 1}
+{"abstract_id": "24550202", "label": "objective", "text": "To describe current US hospital practices with regard to resuscitation care .", "sentence_id": 2}
+{"abstract_id": "24550202", "label": "methods", "text": "A nationally representative mail survey .", "sentence_id": 3}
+{"abstract_id": "24550202", "label": "methods", "text": "A random sample of @ hospitals from the American Hospital Association database , stratified into @ categories by hospital volume tertile and teaching status ( major teaching , minor teaching , and nonteaching ) .", "sentence_id": 4}
+{"abstract_id": "24550202", "label": "methods", "text": "Surveys were addressed to each hospital 's cardiopulmonary resuscitation ( CPR ) committee chair or chief medical/quality officer .", "sentence_id": 5}
+{"abstract_id": "24550202", "label": "methods", "text": "A @-item questionnaire .", "sentence_id": 6}
+{"abstract_id": "24550202", "label": "results", "text": "Responses were received from @ hospitals with a similar distribution of admission volume and teaching status as the sample population ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24550202", "label": "results", "text": "Of the @ ( @ % ) hospitals with a CPR committee , @ ( @ % ) were chaired by a hospitalist .", "sentence_id": 8}
+{"abstract_id": "24550202", "label": "results", "text": "High frequency practices included having a rapid response team ( @ % ) and standardizing defibrillators ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24550202", "label": "results", "text": "Low frequency practices included therapeutic hypothermia and use of CPR assist technology .", "sentence_id": 10}
+{"abstract_id": "24550202", "label": "results", "text": "Other practices such as debriefing ( @ % ) and simulation training ( @ % ) were more variable and correlated with the presence of a CPR committee and/or dedicated personnel for resuscitation quality improvement .", "sentence_id": 11}
+{"abstract_id": "24550202", "label": "results", "text": "The majority of hospitals ( @ % ) reported at least @ barrier to quality improvement , of which the lack of a resuscitation champion and inadequate training were the most common .", "sentence_id": 12}
+{"abstract_id": "24550202", "label": "conclusions", "text": "There is wide variability among hospitals and within practices for resuscitation care in the United States with opportunities for improvement .", "sentence_id": 13}
+{"abstract_id": "24314123", "label": "background", "text": "Medications for respiratory disorders including asthma and chronic obstructive pulmonary disease ( COPD ) are typically delivered to the lung by means of a handheld inhaler .", "sentence_id": 0}
+{"abstract_id": "24314123", "label": "background", "text": "Patient preference for and ability to use the inhaler may influence their adherence to maintenance therapy , and adherence may affect treatment outcomes .", "sentence_id": 1}
+{"abstract_id": "24314123", "label": "background", "text": "In this study , patient experience of using a dry powder inhaler ( DPI ) , the ELLIPTA DPI , in clinical trials of a new maintenance therapy for asthma and COPD was investigated .", "sentence_id": 2}
+{"abstract_id": "24314123", "label": "background", "text": "The ELLIPTA DPI has been designed to contain two separate blister strips from which inhalation powder can be delivered , and to be simple to use with a large , easy-to-read dose counter .", "sentence_id": 3}
+{"abstract_id": "24314123", "label": "methods", "text": "Semi-structured , in-depth , qualitative interviews were carried out @-@ weeks after patients had completed one of six phase IIIa clinical trials using the ELLIPTA DPI .", "sentence_id": 4}
+{"abstract_id": "24314123", "label": "methods", "text": "Interview participants were asked about their satisfaction with various attributes of the inhaler and their preference for the ELLIPTA DPI relative to currently-prescribed inhalers , and responses were explored using an inductive content analysis approach .", "sentence_id": 5}
+{"abstract_id": "24314123", "label": "methods", "text": "Participants also rated the performance of the inhaler on several criteria , using a subjective @-@ scale .", "sentence_id": 6}
+{"abstract_id": "24314123", "label": "results", "text": "Participants with asthma ( n = @ ) and COPD ( n = @ ) reported high levels of satisfaction with the ELLIPTA DPI .", "sentence_id": 7}
+{"abstract_id": "24314123", "label": "results", "text": "It was frequently described as straightforward to operate and easy to use by interview participants .", "sentence_id": 8}
+{"abstract_id": "24314123", "label": "results", "text": "Ergonomic design , mouthpiece fit , and dose counter visibility and ease of interpretation emerged as frequently cited drivers of preference for the ELLIPTA DPI compared with their current prescribed inhaler .", "sentence_id": 9}
+{"abstract_id": "24314123", "label": "results", "text": "Of participants with asthma , @ % preferred the ELLIPTA DPI to DISKUS and @ % to metered dose inhalers .", "sentence_id": 10}
+{"abstract_id": "24314123", "label": "results", "text": "Of participants with COPD , @ % preferred the ELLIPTA DPI to DISKUS , @ % to HandiHaler , and @ % to metered dose inhalers .", "sentence_id": 11}
+{"abstract_id": "24314123", "label": "results", "text": "Overall average performance scores were > @ ( out of @ ) in participants with asthma and COPD .", "sentence_id": 12}
+{"abstract_id": "24314123", "label": "conclusions", "text": "The ELLIPTA DPI was associated with high patient satisfaction and was preferred to other inhalers by interview participants with asthma and COPD .", "sentence_id": 13}
+{"abstract_id": "24314123", "label": "conclusions", "text": "The development of an inhaler that is regarded as easy and intuitive to use may have positive implications for adherence to therapy in asthma and COPD .", "sentence_id": 14}
+{"abstract_id": "24359521", "label": "background", "text": "Despite the high incidence and the economic impact of the common cold , there are still no effective therapeutic options available .", "sentence_id": 0}
+{"abstract_id": "24359521", "label": "background", "text": "Although traditional Chinese medicine ( TCM ) is widely used in China to treat the common cold , there is still a lack of high-quality clinical trials .", "sentence_id": 1}
+{"abstract_id": "24359521", "label": "background", "text": "This article sets forth the protocol for a high-quality trial of a new TCM drug , Baoji Tablets , which is designed to treat the common cold with summer-heat and dampness syndrome ( CCSDS ) .", "sentence_id": 2}
+{"abstract_id": "24359521", "label": "background", "text": "The trial is evaluating both the efficacy and safety of Baoji Tablets .", "sentence_id": 3}
+{"abstract_id": "24359521", "label": "methods", "text": "This study is designed as a multicenter , phase II , parallel-group , double-blind , double-dummy , randomized and placebo-controlled trial .", "sentence_id": 4}
+{"abstract_id": "24359521", "label": "methods", "text": "A total of @ patients will be recruited from four centers .", "sentence_id": 5}
+{"abstract_id": "24359521", "label": "methods", "text": "The new tablets group are administered Baoji Tablets @ g and dummy Baoji Pills @ g.", "sentence_id": 6}
+{"abstract_id": "24359521", "label": "methods", "text": "The old pills group are administered dummy Baoji Tablets @ g and Baoji Pills @ g.", "sentence_id": 7}
+{"abstract_id": "24359521", "label": "methods", "text": "The placebo control group are administered dummy Baoji Tablets @ g and dummy Baoji Pills @ g. All drugs are taken three times daily for @ days .", "sentence_id": 8}
+{"abstract_id": "24359521", "label": "methods", "text": "The primary outcome is the duration of all symptoms .", "sentence_id": 9}
+{"abstract_id": "24359521", "label": "methods", "text": "Secondary outcomes include the duration of primary and secondary symptoms , changes in primary and secondary symptom scores and cumulative symptom score at day @ , as well as an evaluation of treatment efficacy .", "sentence_id": 10}
+{"abstract_id": "24359521", "label": "conclusions", "text": "This is the first multicenter , double-blind , double-dummy , randomized and placebo-controlled trial designated to treat CCSDS in an adult population from China .", "sentence_id": 11}
+{"abstract_id": "24359521", "label": "conclusions", "text": "It will establish the basis for a scientific and objective assessment of the efficacy and safety of Baoji Tablets for treating CCSDS , and provide evidence for a phase III clinical trial .", "sentence_id": 12}
+{"abstract_id": "24905305", "label": "background", "text": "Diabetes is a chronic disease characterized by elevated blood glucose levels .", "sentence_id": 0}
+{"abstract_id": "24905305", "label": "background", "text": "The appropriate goals in the management of diabetes include maintaining blood glucose levels as close to the normal range as possible , minimizing the adverse effects of free radicals by enhancing antioxidant defenses .", "sentence_id": 1}
+{"abstract_id": "24905305", "label": "background", "text": "Supplementation with appropriate vitamins may therefore be of value in the prevention and treatment of diabetes .", "sentence_id": 2}
+{"abstract_id": "24905305", "label": "methods", "text": "A total of @ patients with diabetic neuropathy were enrolled in this randomized controlled study from the general medicine department of a tertiary care hospital .", "sentence_id": 3}
+{"abstract_id": "24905305", "label": "methods", "text": "Patients were randomized into two groups viz. , usual care ( n = @ ) and intervention group ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24905305", "label": "methods", "text": "Usual care group patients received pregabalin with oral hypoglycemic agents .", "sentence_id": 5}
+{"abstract_id": "24905305", "label": "methods", "text": "Patients in the intervention group received vitamin-E along with their regular medicines .", "sentence_id": 6}
+{"abstract_id": "24905305", "label": "methods", "text": "Pain intensity and quality of life ( QoL ) of patients were assessed using Neuropathy Pain Score and RAND @ questionnaire .", "sentence_id": 7}
+{"abstract_id": "24905305", "label": "methods", "text": "Blood samples were analyzed for the levels of random blood sugar level and HbA ( @c ) at the baseline and on the @th week .", "sentence_id": 8}
+{"abstract_id": "24905305", "label": "results", "text": "Significant ( p < @ ) decrease in the random blood sugar level was observed in intervention group when compared with the usual care group and a significant ( p < @ ) reduction in total pain score , and a significant ( p < @ ) improvement in physical health after @ week treatment of vitamin-E was observed .", "sentence_id": 9}
+{"abstract_id": "24905305", "label": "conclusions", "text": "The study concluded that vitamin-E is a natural antioxidant and it is found to be effective in reducing pain score in diabetic neuropathy patients .", "sentence_id": 10}
+{"abstract_id": "24905305", "label": "conclusions", "text": "The future studies may be directed towards extended duration of action .", "sentence_id": 11}
+{"abstract_id": "24411681", "label": "background", "text": "Childbirth is an important experience in a woman 's life , and unfavorable birth experiences have been shown to negatively impact postpartum maternal health .", "sentence_id": 0}
+{"abstract_id": "24411681", "label": "background", "text": "Aim of this study was to evaluate the effects of music therapy on postpartum pain , anxiety level , satisfaction and early pospartum depression rate .", "sentence_id": 1}
+{"abstract_id": "24411681", "label": "methods", "text": "Totally @ primiparous women were recruited and randomized either music group ( n = @ ) or a control group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24411681", "label": "methods", "text": "Women in the music group listened to self-selected music during labor .", "sentence_id": 3}
+{"abstract_id": "24411681", "label": "methods", "text": "Postpartum pain intensity , anxiety level and satisfaction rate were measured using the visual analog scale ( VAS ) , postpartum depression rate was assessed with Edinburg Postpartum Depression Scale ( EPDS ) at postpartum day one and day eight .", "sentence_id": 4}
+{"abstract_id": "24411681", "label": "results", "text": "Mothers in the music therapy group had a lower level of postpartum pain and anxiety than the control group and it was statistically significant at all time intervals ( @ , @ , @ , @ and @h , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24411681", "label": "results", "text": "A significant difference was observed between the two groups in terms of satisfaction rate ( p < @ ) and postpartum depression rate at postpartum day one and day eight ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24411681", "label": "conclusions", "text": "We only measured the effect of music therapy on early postpartum depression rate .", "sentence_id": 7}
+{"abstract_id": "24411681", "label": "conclusions", "text": "Effect of music on late postpartum depression rate should be investigated in future .", "sentence_id": 8}
+{"abstract_id": "24411681", "label": "conclusions", "text": "Using music therapy during labor decreased postpartum anxiety and pain , increased the satisfaction with childbirth and reduced early postpartum depression rate .", "sentence_id": 9}
+{"abstract_id": "24411681", "label": "conclusions", "text": "Music therapy can be clinically recommended as an alternative , safe , easy and enjoyable nonpharmacological method for postpartum well-being .", "sentence_id": 10}
+{"abstract_id": "24606626", "label": "background", "text": "Learners can focus on mastery ( i.e. task orientation ) or on learning relative to others ( i.e. ego orientation ) .", "sentence_id": 0}
+{"abstract_id": "24606626", "label": "background", "text": "Previous research suggests task orientations are optimal for learning , a benefit usually linked to the suggestion that qualitative comments are better for learning than quantitative comparisons ( i.e. grades ) .", "sentence_id": 1}
+{"abstract_id": "24606626", "label": "background", "text": "Yet , it is not clear if the observed effects are attributable to the feedback orientation ( i.e. task versus ego ) , feedback format ( i.e. comments versus numerical scores ) , or an interaction between the two .", "sentence_id": 2}
+{"abstract_id": "24606626", "label": "background", "text": "Here , we aimed to clarify the effects of feedback orientation and feedback format during simulation-based training in endotracheal intubation .", "sentence_id": 3}
+{"abstract_id": "24606626", "label": "methods", "text": "Forty-one medical students were randomly assigned to four feedback conditions : Task-oriented Numerical ; Ego-oriented Numerical ; Task-oriented Comment , and Ego-oriented Comment .", "sentence_id": 4}
+{"abstract_id": "24606626", "label": "methods", "text": "Participants performed a total of @ trials of endotracheal intubation .", "sentence_id": 5}
+{"abstract_id": "24606626", "label": "methods", "text": "Pre-test , post-test and retention test assessments included the use of hand motion analysis and a global rating scale ( GRS ) .", "sentence_id": 6}
+{"abstract_id": "24606626", "label": "methods", "text": "Participants rated feedback credibility , self-assessment and self-confidence using Likert-type scales .", "sentence_id": 7}
+{"abstract_id": "24606626", "label": "methods", "text": "Analyses of variance were used to examine group differences .", "sentence_id": 8}
+{"abstract_id": "24606626", "label": "results", "text": "Participants ' performance did not differ significantly on the easiest ( p > @ ) or two complex variations of intubation ( p > @ ) .", "sentence_id": 9}
+{"abstract_id": "24606626", "label": "results", "text": "For the moderately difficult variation , analyses of hand motion and GRS data revealed significant group differences at post-test ( p < @ ) , but no differences on the retention test .", "sentence_id": 10}
+{"abstract_id": "24606626", "label": "results", "text": "Analysis of participants ' perceptions showed significant interactions whereby the Ego-oriented Numerical group rated feedback credibility ( p < @ ) higher than the Task-oriented Numerical group ; the two Comment groups did not differ .", "sentence_id": 11}
+{"abstract_id": "24606626", "label": "results", "text": "Some participants recounted negative experiences with the feedback they received .", "sentence_id": 12}
+{"abstract_id": "24606626", "label": "conclusions", "text": "Medical students responded to feedback in ways that challenge previous education research .", "sentence_id": 13}
+{"abstract_id": "24606626", "label": "conclusions", "text": "Specifically , students preferred and improved more in the short term ( but not at retention ) when receiving Ego-oriented feedback in Numerical form .", "sentence_id": 14}
+{"abstract_id": "24606626", "label": "conclusions", "text": "Although learning retention did not differ significantly across feedback conditions , students ' perceptions of themselves and of the teacher and training environment did differ and the implications for trainees ' future learning must be considered .", "sentence_id": 15}
+{"abstract_id": "26349123", "label": "objective", "text": "To evaluate the in situ caries performance and safety of two experimental fluoride dentifrice formulations ( @ ppm fluoride ) with and without @ % isopentane as an excipient , in comparison to a positive control , currently marketed dentifrice ( @ ppm fluoride ) and a negative control dentifrice ( @ ppm fluoride ) .", "sentence_id": 0}
+{"abstract_id": "26349123", "label": "methods", "text": "This was a single-center , examiner-blind , randomized , controlled , four-treatment cross-over study .", "sentence_id": 1}
+{"abstract_id": "26349123", "label": "methods", "text": "During each treatment period , the subject wore a modified mandibular partial denture fitted with two gauze-covered , partially demineralized human enamel specimens , and brushed at home for one timed minute , twice daily , for two weeks .", "sentence_id": 2}
+{"abstract_id": "26349123", "label": "methods", "text": "At the end of each treatment period , the enamel specimens were removed from the dentures for analysis .", "sentence_id": 3}
+{"abstract_id": "26349123", "label": "methods", "text": "During the week between treatment periods , subjects returned to their usual dental hygiene practices for four to five days , received a dental prophylaxis , and used a study-designated non-fluoride dentifrice for two to three days before starting the next treatment .", "sentence_id": 4}
+{"abstract_id": "26349123", "label": "methods", "text": "Treatment effect on enamel specimen remineralization was assessed by surface microhardness ( SMH ) .", "sentence_id": 5}
+{"abstract_id": "26349123", "label": "methods", "text": "Enamel fluoride uptake was assessed using microdrill enamel biopsy .", "sentence_id": 6}
+{"abstract_id": "26349123", "label": "results", "text": "All fluoride-containing dentifrices demonstrated significant , superior SMH recovery and levels of fluoride uptake compared to the negative control dentifrice .", "sentence_id": 7}
+{"abstract_id": "26349123", "label": "results", "text": "No significant differences were observed for either efficacy variable between the experimental dentifrice formulations and the positive control dentifrice .", "sentence_id": 8}
+{"abstract_id": "26349123", "label": "results", "text": "No significant difference was observed between the @ % isopentane dentifrice and the @ % isopentane dentifrice for SMH recovery .", "sentence_id": 9}
+{"abstract_id": "26349123", "label": "conclusions", "text": "The addition of @ % isopentane did not positively or negatively affect fluoride efficacy in this model .", "sentence_id": 10}
+{"abstract_id": "25467848", "label": "background", "text": "PBT@ is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington 's disease .", "sentence_id": 0}
+{"abstract_id": "25467848", "label": "background", "text": "We aimed to assess the safety , tolerability , and efficacy of PBT@ in patients with Huntington 's disease .", "sentence_id": 1}
+{"abstract_id": "25467848", "label": "methods", "text": "In this @-week , randomised , double-blind , placebo-controlled trial , adults ( @ years old ) with early-stage to mid-stage Huntington 's disease were randomly assigned ( @:@:@ ) by a centralised interactive response system to once daily PBT@ @ mg , PBT@ @ mg , or placebo .", "sentence_id": 2}
+{"abstract_id": "25467848", "label": "methods", "text": "Randomisation was stratified by site with a block size of three .", "sentence_id": 3}
+{"abstract_id": "25467848", "label": "methods", "text": "Participants , carers , the steering committee , site investigators , study staff , and the study sponsor were masked to treatment assignment .", "sentence_id": 4}
+{"abstract_id": "25467848", "label": "methods", "text": "Primary endpoints were safety and tolerability .", "sentence_id": 5}
+{"abstract_id": "25467848", "label": "methods", "text": "The safety population consisted of all participants who were randomly assigned and had at least one dose of study drug .", "sentence_id": 6}
+{"abstract_id": "25467848", "label": "methods", "text": "The principal secondary endpoint was cognition , measured by the change from baseline to week @ in the main composite Z score of five cognitive tests ( Category Fluency Test , Trail Making Test Part B , Map Search , Symbol Digit Modalities Test , and Stroop Word Reading Test ) and scores on eight individual cognitive tests ( the five aforementioned plus the Trail Making Test Part A , Montreal Cognitive Assessment , and the Speeded Tapping Test ) .", "sentence_id": 7}
+{"abstract_id": "25467848", "label": "methods", "text": "The intention-to-treat population comprised participants who were randomly assigned and had at least one efficacy assessment after administration of study drug .", "sentence_id": 8}
+{"abstract_id": "25467848", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 9}
+{"abstract_id": "25467848", "label": "results", "text": "Between April @ , @ , and Dec @ , @ , @ participants were randomly assigned to PBT@ @ mg ( n = @ ) , PBT@ @ mg ( n = @ ) , or placebo ( n = @ ) at @ research centres in Australia and the USA .", "sentence_id": 10}
+{"abstract_id": "25467848", "label": "results", "text": "@ ( @ % ) individuals on PBT@ @ mg , @ ( @ % ) on PBT@ @ mg , and @ ( @ % ) on placebo completed the study .", "sentence_id": 11}
+{"abstract_id": "25467848", "label": "results", "text": "Six serious adverse events ( acute coronary syndrome , major depression , pneumonia , suicide attempt , viral infection , and worsening of Huntington 's disease ) occurred in five participants in the PBT@ @ mg group , three ( fall with subdural haematoma , suicide attempt , and hospital admission for stabilisation of Huntington 's disease ) occurred in two participants in the PBT@ @ mg group , and one ( increasing aggression ) occurred in a participant in the placebo group .", "sentence_id": 12}
+{"abstract_id": "25467848", "label": "results", "text": "The site investigators deemed all , except the worsening of Huntington 's disease , as unrelated to study drug .", "sentence_id": 13}
+{"abstract_id": "25467848", "label": "results", "text": "@ ( @ % ) participants on PBT@ @ mg , @ ( @ % ) on PBT@ @ mg , and @ ( @ % ) on placebo had at least one adverse event .", "sentence_id": 14}
+{"abstract_id": "25467848", "label": "results", "text": "Compared with placebo , neither PBT@ @ mg ( least-squares mean @ , @ % CI -@ to @ ; p = @ ) nor PBT@ @ mg ( @ , -@ to @ ; p = @ ) significantly improved the main composite cognition Z score between baseline and @ weeks .", "sentence_id": 15}
+{"abstract_id": "25467848", "label": "results", "text": "Compared with placebo , the Trail Making Test Part B score was improved between baseline and @ weeks in the PBT@ @ mg group ( @ s , @-@ ; p = @ ) but not in the @ mg group ( @ s improvement , -@ to @ ; p = @ ) ; neither dose significantly improved cognition on the other tests .", "sentence_id": 16}
+{"abstract_id": "25467848", "label": "conclusions", "text": "PBT@ was generally safe and well tolerated in patients with Huntington 's disease .", "sentence_id": 17}
+{"abstract_id": "25467848", "label": "conclusions", "text": "The potential benefit on executive function will need to be confirmed in a larger study .", "sentence_id": 18}
+{"abstract_id": "25365717", "label": "methods", "text": "A retrospective radiographical study .", "sentence_id": 0}
+{"abstract_id": "25365717", "label": "objective", "text": "To construct a predictive model for pelvic tilt ( PT ) based on the sacrofemoral-pubic ( SFP ) angle in patients with thoracolumbar kyphosis secondary to ankylosing spondylitis ( or AS ) .", "sentence_id": 1}
+{"abstract_id": "25365717", "label": "background", "text": "PT is a key pelvic parameter in the regulation of spine sagittal alignment that can be used to plan the appropriate osteotomy angle in patients with AS with thoracolumbar kyphosis .", "sentence_id": 2}
+{"abstract_id": "25365717", "label": "background", "text": "However , it could be difficult to measure PT in patients with femoral heads poorly visualized on lateral radiographs .", "sentence_id": 3}
+{"abstract_id": "25365717", "label": "background", "text": "Previous studies showed that the SFP angle could be used to evaluate PT in adult patients with scoliosis .", "sentence_id": 4}
+{"abstract_id": "25365717", "label": "background", "text": "However , this method has not been validated in patients with AS .", "sentence_id": 5}
+{"abstract_id": "25365717", "label": "methods", "text": "A total of @ patients with AS with thoracolumbar kyphosis were included .", "sentence_id": 6}
+{"abstract_id": "25365717", "label": "methods", "text": "Full-length anteroposterior and lateral spine radiographs were all available , with spinal and pelvic anatomical landmarks clearly identified .", "sentence_id": 7}
+{"abstract_id": "25365717", "label": "methods", "text": "PT , SFP angle , and global kyphosis were measured .", "sentence_id": 8}
+{"abstract_id": "25365717", "label": "methods", "text": "The patients were randomly divided into group A ( n = @ ) and group B ( n = @ ) .", "sentence_id": 9}
+{"abstract_id": "25365717", "label": "methods", "text": "In group A , the predictive model for PT was constructed by the results of the linear regression analysis .", "sentence_id": 10}
+{"abstract_id": "25365717", "label": "methods", "text": "In group B , the predictive ability and accuracy of the predictive model were investigated .", "sentence_id": 11}
+{"abstract_id": "25365717", "label": "results", "text": "In group A , the Pearson correlation analysis revealed a strong correlation between the SFP angle and PT ( r = @ ; P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25365717", "label": "results", "text": "The predictive model for PT was constructed as PT = @-@ @ ( SFP angle ) .", "sentence_id": 13}
+{"abstract_id": "25365717", "label": "results", "text": "In group B , PT was predicted by the model with a mean error of @ ( SD = @ ) with a predictive value of @ % .", "sentence_id": 14}
+{"abstract_id": "25365717", "label": "conclusions", "text": "PT can be accurately predicted by the SFP angle using the current model : PT = @-@ @ ( SFP angle ) , when the femur heads are poorly visualized on lateral radiographs in patients with AS with thoracolumbar kyphosis .", "sentence_id": 15}
+{"abstract_id": "25407792", "label": "background", "text": "In type @ diabetes , acute hyperglycemia worsens endothelial function and inflammation , while resistance to GLP-@ action occurs .", "sentence_id": 0}
+{"abstract_id": "25407792", "label": "background", "text": "All these phenomena seem to be related to the generation of oxidative stress .", "sentence_id": 1}
+{"abstract_id": "25407792", "label": "background", "text": "A Mediterranean diet , supplemented with olive oil , increases plasma antioxidant capacity , suggesting that its implementation can have a favorable effect on the aforementioned phenomena .", "sentence_id": 2}
+{"abstract_id": "25407792", "label": "background", "text": "In the present study , we test the hypothesis that a Mediterranean diet using olive oil can counteract the effects of acute hyperglycemia and can improve the resistance of the endothelium to GLP-@ action .", "sentence_id": 3}
+{"abstract_id": "25407792", "label": "methods", "text": "Two groups of type @ diabetic patients , each consisting of twelve subjects , participated in a randomized trial for three months , following a Mediterranean diet using olive oil or a control low-fat diet .", "sentence_id": 4}
+{"abstract_id": "25407792", "label": "methods", "text": "Plasma antioxidant capacity , endothelial function , nitrotyrosine , @-iso-PGF@a , IL-@ and ICAM-@ levels were evaluated at baseline and at the end of the study .", "sentence_id": 5}
+{"abstract_id": "25407792", "label": "methods", "text": "The effect of GLP-@ during a hyperglycemic clamp , was also studied at baseline and at the end of the study .", "sentence_id": 6}
+{"abstract_id": "25407792", "label": "results", "text": "Compared to the control diet , the Mediterranean diet increased plasma antioxidant capacity and improved basal endothelial function , nitrotyrosine , @-iso-PGF@a , IL-@ and ICAM-@ levels .", "sentence_id": 7}
+{"abstract_id": "25407792", "label": "results", "text": "The Mediterranean diet also reduced the negative effects of acute hyperglycemia , induced by a hyperglycemic clamp , on endothelial function , nitrotyrosine , @-iso-PGF@a , IL-@ and ICAM-@ levels .", "sentence_id": 8}
+{"abstract_id": "25407792", "label": "results", "text": "Furthermore , the Mediterranean diet improved the protective action of GLP-@ on endothelial function , nitrotyrosine , @-iso-PGF@a , IL-@ and ICAM-@ levels , also increasing GLP-@-induced insulin secretion .", "sentence_id": 9}
+{"abstract_id": "25407792", "label": "conclusions", "text": "These data suggest that the Mediterranean diet , using olive oil , prevents the acute hyperglycemia effect on endothelial function , inflammation and oxidative stress , and improves the action of GLP-@ , which may have a favorable effect on the management of type @ diabetes , particularly for the prevention of cardiovascular disease .", "sentence_id": 10}
+{"abstract_id": "24685956", "label": "objective", "text": "To investigate the effect of a @-month physical activity intervention on cardiorespiratory fitness and adiposity among prepubertal children .", "sentence_id": 0}
+{"abstract_id": "24685956", "label": "methods", "text": "Prepubertal children ( @ - to @-year-olds , N = @ , @ girls ) were randomly assigned to a @-month physical activity intervention or a control group .", "sentence_id": 1}
+{"abstract_id": "24685956", "label": "methods", "text": "The intervention provided @ minutes ( @ days/week ) of moderate to vigorous physical activity .", "sentence_id": 2}
+{"abstract_id": "24685956", "label": "methods", "text": "Maximum oxygen consumption ( Vo@max percentile ) and dual-energy radiograph absorptiometry measured cardiorespiratory fitness and adiposity , respectively .", "sentence_id": 3}
+{"abstract_id": "24685956", "label": "methods", "text": "Intention-to-treat analysis was performed to assess baseline and follow-up cardiorespiratory fitness , percentage fat mass ( % FM ) , percentage central fat mass ( % CFM ) , and estimated visceral adipose tissue ( VAT ) area .", "sentence_id": 4}
+{"abstract_id": "24685956", "label": "results", "text": "The intervention group increased in cardiorespiratory fitness ( @ th percentile ; @ % confidence interval -LSB- CI -RSB- , @ to @ ) and decreased in % FM ( -@ % ; @ % CI , -@ to -@ ) and % CFM ( -@ % ; @ % CI , -@ to -@ ) .", "sentence_id": 5}
+{"abstract_id": "24685956", "label": "results", "text": "Reductions in % FM were evident for both nonoverweight ( -@ % ; @ % CI , -@ to -@ ) and overweight or obese ( -@ % ; @ % CI,-@ @ to -@ ) intervention participants .", "sentence_id": 6}
+{"abstract_id": "24685956", "label": "results", "text": "Conversely , the control group displayed no change in cardiorespiratory fitness while exhibiting increases in % FM ( @ % ; @ % CI , @ to @ ) , % CFM ( @ ; @ % CI , @ to @ ) , and VAT area ( @ cm ( @ ) ; @ % CI , @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "24685956", "label": "results", "text": "Nonoverweight control participants increased in % FM ( @ % ; @ % CI , @ to @ ) , and their overweight and obese counterparts increased in VAT ( @ cm ( @ ) ; @ % CI , @ to @ ) .", "sentence_id": 8}
+{"abstract_id": "24685956", "label": "conclusions", "text": "The physical activity intervention improved cardiorespiratory fitness , reduced % FM , and prevented accumulation of % CFM among prepubertal children with varying adiposity levels .", "sentence_id": 9}
+{"abstract_id": "24685956", "label": "conclusions", "text": "These findings provide support for daily physical activity recommendations to prevent excess fat mass accumulation in childhood .", "sentence_id": 10}
+{"abstract_id": "24253615", "label": "background", "text": "Applying a direct renin inhibitor ( DRI ) to advanced stage chronic kidney disease ( CKD ) patients is a matter of controversy .", "sentence_id": 0}
+{"abstract_id": "24253615", "label": "background", "text": "The purpose of this study was to evaluate the effect of the DRI , aliskiren , in patients with therapy-resistant hypertension undergoing hemodialysis ( HD ) .", "sentence_id": 1}
+{"abstract_id": "24253615", "label": "methods", "text": "The study was a prospective , randomized multicenter trial exploring the antihypertensive effect of aliskiren in comparison with amlodipine , a calcium channel blocker , in patients undergoing HD .", "sentence_id": 2}
+{"abstract_id": "24253615", "label": "methods", "text": "A total of @ participants whose blood pressure ( BP ) had previously been treated with more than one antihypertensive agent and not having achieved the BP goal of < @/@ mmHg were randomly assigned to either aliskiren @ mg or amlodipine @ mg as an add-on therapy .", "sentence_id": 3}
+{"abstract_id": "24253615", "label": "results", "text": "A significant decrease in pre-dialysis clinic BP and home BP was found only in the amlodipine group and not in the aliskiren group .", "sentence_id": 4}
+{"abstract_id": "24253615", "label": "results", "text": "In contrast , there was a significant decrease in atrial natriuretic peptide ( ANP ) in the aliskiren group but not in the amlodipine group .", "sentence_id": 5}
+{"abstract_id": "24253615", "label": "results", "text": "N-terminal pro-B-type natriuretic hormone remained unchanged in both groups .", "sentence_id": 6}
+{"abstract_id": "24253615", "label": "results", "text": "Aliskiren significantly reduced angiotensin I and II , plasma renin activity , and increased plasma renin content .", "sentence_id": 7}
+{"abstract_id": "24253615", "label": "results", "text": "However , such changes were not observed in the amlodipine group .", "sentence_id": 8}
+{"abstract_id": "24253615", "label": "conclusions", "text": "Amlodipine , not aliskiren , effectively reduces BP in CKD patients with refractory hypertension undergoing HD .", "sentence_id": 9}
+{"abstract_id": "24253615", "label": "conclusions", "text": "Aliskiren suppresses the renin-angiotensin system and reduces ANP .", "sentence_id": 10}
+{"abstract_id": "24253615", "label": "conclusions", "text": "Whether the DRI is beneficial in improving cardiovascular events in patients undergoing HD remains to be elucidated in future studies .", "sentence_id": 11}
+{"abstract_id": "25444961", "label": "objective", "text": "We determined the feasibility of a definitive trial comparing the effectiveness of group vs individual urotherapy for children with bladder-bowel dysfunction .", "sentence_id": 0}
+{"abstract_id": "25444961", "label": "methods", "text": "Children @ to @ years old with bladder-bowel dysfunction were recruited during the course of @ year .", "sentence_id": 1}
+{"abstract_id": "25444961", "label": "methods", "text": "Feasibility data on screening , eligibility , recruitment and protocol compliance rates were collected .", "sentence_id": 2}
+{"abstract_id": "25444961", "label": "methods", "text": "Patients with high grade hydronephrosis , vesicoureteral reflux or learning disabilities and those who had previously undergone urotherapy were excluded .", "sentence_id": 3}
+{"abstract_id": "25444961", "label": "methods", "text": "Patients were randomized to @-hour group urotherapy or @-minute individual urotherapy .", "sentence_id": 4}
+{"abstract_id": "25444961", "label": "methods", "text": "Symptoms and quality of life were measured using the Vancouver Nonneurogenic Lower Urinary Tract Dysfunction/Dysfunctional Elimination Syndrome Questionnaire and the Pediatric Incontinence Questionnaire at baseline and at @ to @ months of followup .", "sentence_id": 5}
+{"abstract_id": "25444961", "label": "methods", "text": "Within/between group comparisons were conducted using t-tests .", "sentence_id": 6}
+{"abstract_id": "25444961", "label": "results", "text": "Of @ screened children @ were eligible and @ were recruited to participate .", "sentence_id": 7}
+{"abstract_id": "25444961", "label": "results", "text": "A total of @ patients randomized to group urotherapy and @ randomized to individual urotherapy completed the pilot trial ( @ undergoing group and @ undergoing individual urotherapy withdrew from the study ) .", "sentence_id": 8}
+{"abstract_id": "25444961", "label": "results", "text": "Symptomology scores between group and individual urotherapy were not different at followup ( mean SD @ @ vs @ @ , p = @ , @ % CI -@ -@ ) .", "sentence_id": 9}
+{"abstract_id": "25444961", "label": "results", "text": "Quality of life scores between patients undergoing group and individual urotherapy at baseline differed ( mean SD @ @ vs @ @ , p < @ , @ % CI @-@ @ ) but became similar at followup ( @ @ vs @ @ , p = @ , @ % CI -@ -@ ) .", "sentence_id": 10}
+{"abstract_id": "25444961", "label": "results", "text": "Within group analyses demonstrated improvement in symptomology from baseline to followup in patients undergoing group ( mean SD @ @ , p = @ , @ % CI @-@ @ ) and individual urotherapy ( @ @ , p < @ , @ % CI @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "25444961", "label": "results", "text": "Within group quality of life analyses revealed improvement in Pediatric Incontinence Questionnaire scores from baseline to followup in patients undergoing individual urotherapy ( p < @ , @ % CI @-@ @ ) only .", "sentence_id": 12}
+{"abstract_id": "25444961", "label": "conclusions", "text": "Urotherapy , regardless of modality , effectively improved bladder-bowel dysfunction symptoms .", "sentence_id": 13}
+{"abstract_id": "25444961", "label": "conclusions", "text": "A definitive randomized controlled trial is feasible , considering that a high recruitment rate ( @ % ) for this population has been established .", "sentence_id": 14}
+{"abstract_id": "24412265", "label": "objective", "text": "To describe changes in and predictors of comfortable gait speed ( GS-C ) after using a foot-drop stimulator ( FDS ; Bioness L@ ; Bioness Inc , Valencia , CA ) for @ weeks in persons who had sustained a stroke .", "sentence_id": 0}
+{"abstract_id": "24412265", "label": "methods", "text": "Secondary analysis of prospective assessments .", "sentence_id": 1}
+{"abstract_id": "24412265", "label": "methods", "text": "Multicenter clinical trial .", "sentence_id": 2}
+{"abstract_id": "24412265", "label": "methods", "text": "A total of @ subjects who had sustained a stroke @ months earlier and who had GS-C @ m/s and drop foot with a mean age of @ years and a poststroke time of @ years .", "sentence_id": 3}
+{"abstract_id": "24412265", "label": "methods", "text": "GS-C was assessed at baseline and at @ weeks with and without use of an FDS ( therapeutic effect ) and at @ , @ , @ , @ , and @ weeks with use of an FDS ( total effect ) .", "sentence_id": 4}
+{"abstract_id": "24412265", "label": "methods", "text": "After subjects participated in @ physical therapy sessions , an FDS was used for ambulation over the course of @ weeks .", "sentence_id": 5}
+{"abstract_id": "24412265", "label": "methods", "text": "Changes in mean GS-C over time , FDS `` responder '' status defined as either @ m/s gain in GS-C ( the minimal clinically important difference -LSB- MCID -RSB- ) or advancing by one Perry Ambulation Category ( PAC ) , and the incidence and nature of adverse events ( AEs ) .", "sentence_id": 6}
+{"abstract_id": "24412265", "label": "results", "text": "A total of @ ( @ % ) and @ ( @ % ) of @ subjects completed assessments at @ weeks and @ weeks , respectively .", "sentence_id": 7}
+{"abstract_id": "24412265", "label": "results", "text": "Baseline GS-C was @ m/s without use of an FDS and @ m/s with use of an FDS .", "sentence_id": 8}
+{"abstract_id": "24412265", "label": "results", "text": "GS-C improved to @ m/s at @ weeks without use of an FDS ( effect size = @ ) and @ , @ , @ , @ , and @ m/s at @ , @ , @ , @ , and @ weeks with use of an FDS , respectively ( effect size @ at @ weeks ) .", "sentence_id": 9}
+{"abstract_id": "24412265", "label": "results", "text": "Half of the subjects achieved a maximum GS-C by @ weeks .", "sentence_id": 10}
+{"abstract_id": "24412265", "label": "results", "text": "Approximately @ % were PAC responders and @ % were MCID responders for @-week therapeutic effect , and @ % were PAC responders and @ % were MCID responders for @-week total effect .", "sentence_id": 11}
+{"abstract_id": "24412265", "label": "results", "text": "After logistic regression , the following factors emerged as the strongest predictors of FDS responders : younger age , faster baseline GS-C and Timed Up and Go , and balance .", "sentence_id": 12}
+{"abstract_id": "24412265", "label": "results", "text": "At @ weeks , @ % reported a device-related AE ; @ % were mild and @ % were anticipated .", "sentence_id": 13}
+{"abstract_id": "24412265", "label": "conclusions", "text": "When an FDS was used , GS-C improved progressively over @ weeks , with @ % of patients achieving a clinically meaningful @-week total effect and @ % achieving a maximum GS-C by @ weeks .", "sentence_id": 14}
+{"abstract_id": "24412265", "label": "conclusions", "text": "Younger patients with greater mobility levels may benefit most from use of an FDS .", "sentence_id": 15}
+{"abstract_id": "24412265", "label": "conclusions", "text": "AEs were frequent , mild , and reversible .", "sentence_id": 16}
+{"abstract_id": "24407163", "label": "background", "text": "One of the advantages of Internet-based research is the ability to efficiently recruit large , diverse samples of international participants .", "sentence_id": 0}
+{"abstract_id": "24407163", "label": "background", "text": "Currently , there is a dearth of information on the behind-the-scenes process to setting up successful online recruitment tools .", "sentence_id": 1}
+{"abstract_id": "24407163", "label": "objective", "text": "The objective of the study was to examine the comparative impact of Spanish - and English-language keywords for a Google AdWords campaign to recruit pregnant women to an Internet intervention and to describe the characteristics of those who enrolled in the trial .", "sentence_id": 2}
+{"abstract_id": "24407163", "label": "methods", "text": "Spanish - and English-language Google AdWords campaigns were created to advertise and recruit pregnant women to a Web-based randomized controlled trial for the prevention of postpartum depression , the Mothers and Babies/Mams y Bebs Internet Project .", "sentence_id": 3}
+{"abstract_id": "24407163", "label": "methods", "text": "Search engine users who clicked on the ads in response to keyword queries ( eg , pregnancy , depression and pregnancy ) were directed to the fully automated study website .", "sentence_id": 4}
+{"abstract_id": "24407163", "label": "methods", "text": "Data on the performance of keywords associated with each Google ad reflect Web user queries from February @ to June @ .", "sentence_id": 5}
+{"abstract_id": "24407163", "label": "methods", "text": "Demographic information , self-reported depression symptom scores , major depressive episode status , and Internet use data were collected from enrolled participants before randomization in the intervention study .", "sentence_id": 6}
+{"abstract_id": "24407163", "label": "results", "text": "The Google ads received high exposure ( @,@,@ impressions ) and interest ( @,@ clicks ) from a global sample of Web users ; @ pregnant women consented to participate and @ completed enrollment in the intervention study .", "sentence_id": 7}
+{"abstract_id": "24407163", "label": "results", "text": "Keywords that were descriptive of pregnancy and distress or pregnancy and health resulted in higher consent and enrollment rates ( i.e. , high-performing ads ) .", "sentence_id": 8}
+{"abstract_id": "24407163", "label": "results", "text": "In both languages , broad keywords ( eg , pregnancy ) had the highest exposure , more consented participants , and greatest cost per consent ( up to US $ @ per consent ) .", "sentence_id": 9}
+{"abstract_id": "24407163", "label": "results", "text": "The online ads recruited a predominantly Spanish-speaking sample from Latin America of Mestizo racial identity .", "sentence_id": 10}
+{"abstract_id": "24407163", "label": "results", "text": "The English-speaking sample was also diverse with most participants residing in regions of Asia and Africa .", "sentence_id": 11}
+{"abstract_id": "24407163", "label": "results", "text": "Spanish-speaking participants were significantly more likely to be of Latino ethnic background , not married , completed fewer years of formal education , and were more likely to have accessed the Internet for depression information ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24407163", "label": "conclusions", "text": "The Internet is an effective method for reaching an international sample of pregnant women interested in online interventions to manage changes in their mood during the perinatal period .", "sentence_id": 13}
+{"abstract_id": "24407163", "label": "conclusions", "text": "To increase efficiency , Internet advertisements need to be monitored and tailored to reflect the target population 's conceptualization of health issues being studied .", "sentence_id": 14}
+{"abstract_id": "25307976", "label": "background", "text": "Excessive systemic inflammatory response remains as a major problem underlying severe burns .", "sentence_id": 0}
+{"abstract_id": "25307976", "label": "background", "text": "This study aimed to assess the effect of low-dose glucocorticoid treatment in downregulating systemic inflammation in severely burned patients .", "sentence_id": 1}
+{"abstract_id": "25307976", "label": "methods", "text": "A prospective study from @ to @ at our hospital was conducted to compare the patients who received low-dose glucocorticoid during the acute phase with those who did not .", "sentence_id": 2}
+{"abstract_id": "25307976", "label": "methods", "text": "Patients with burns @ % or greater of their total body surface area were included , and their plasma levels of inflammatory cytokines and clinical outcomes were compared .", "sentence_id": 3}
+{"abstract_id": "25307976", "label": "results", "text": "A total of @ patients were included in this study , with @ patients receiving glucocorticoid treatment and the others not .", "sentence_id": 4}
+{"abstract_id": "25307976", "label": "results", "text": "Patient demographics including age , burn size , and incidence of inhalation injury were similar in both groups .", "sentence_id": 5}
+{"abstract_id": "25307976", "label": "results", "text": "The incidence of pulmonary infection and stress ulcer ( and/or hemorrhage ) was @ % and @ % in the treatment group , respectively , significantly lower than @ % and @ % of the control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25307976", "label": "results", "text": "Length of hospital stay was almost @ days shorter in the treatment group ( P < @ ) , whereas there was no significant difference in the overall mortality , duration of mechanical ventilation , and incidence of sepsis between the @ groups .", "sentence_id": 7}
+{"abstract_id": "25307976", "label": "results", "text": "The enzyme-linked immunosorbent assay results confirmed that the plasma levels of C-reactive protein , tumor necrosis factor - , interleukin-@ , and interleukin-@ were significantly lower in the treatment group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25307976", "label": "conclusions", "text": "Low dose of glucocorticoid treatment during the acute phase could reduce the levels of proinflammatory cytokines in severely burned patients and subsequently decrease the incidence of pulmonary infection and stress ulcer , as well as the length of hospital stay .", "sentence_id": 9}
+{"abstract_id": "24550580", "label": "objective", "text": "To compare the effectiveness and safety of add on therapy of bromocriptine with metformin in type @ diabetes mellitus ( DM ) patients .", "sentence_id": 0}
+{"abstract_id": "24550580", "label": "methods", "text": "Adult type @ DM patients fulfilling the inclusion criteria were randomized in three groups .", "sentence_id": 1}
+{"abstract_id": "24550580", "label": "methods", "text": "Group A received metformin ( @ mg / day ) , while group B patients were treated with metformin ( @ mg/day ) plus bromocriptine ( @ mg/day ) and group C received metformin ( @ mg/day ) plus bromocriptine ( @ mg/day ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24550580", "label": "methods", "text": "Fasting plasma glucose ( FPG ) , postprandial plasma glucose ( PPPG ) , and body weight were measured at week @ , @ , and @ visits and glycosylated hemoglobin ( HbA ( @C ) ) at week @ visit .", "sentence_id": 3}
+{"abstract_id": "24550580", "label": "results", "text": "Metformin alone and in combination with bromocriptine in escalating dose ( @ mg/day and @ mg/day ) significantly ( P < @ ) decreased FPG and PPPG levels at weeks @ , @ , and @ compared with pretreatment values .", "sentence_id": 4}
+{"abstract_id": "24550580", "label": "results", "text": "HbA ( @C ) level in all three treatment groups significantly ( P < @ ) decreased at week @ as compared with pretreatment baseline value .", "sentence_id": 5}
+{"abstract_id": "24550580", "label": "results", "text": "HbA@C level in groups B and C significantly ( P < @ ) decreased as compared with group A at week @ .", "sentence_id": 6}
+{"abstract_id": "24550580", "label": "results", "text": "Addition of bromocriptine to metformin also significantly ( P < @ ) decreased FPG and PPPG levels in a dose-dependent manner as compared with metformin alone .", "sentence_id": 7}
+{"abstract_id": "24550580", "label": "results", "text": "Intergroup analysis did not show any statistically significant change in weight of study subjects at different intervals .", "sentence_id": 8}
+{"abstract_id": "24550580", "label": "conclusions", "text": "The combination of bromocriptine with metformin significantly decreased FPG , PPPG , and HbA@C compared with metformin alone in type @ DM patients in a dose-dependent manner .", "sentence_id": 9}
+{"abstract_id": "24529671", "label": "objective", "text": "Nowadays , conventional analgesic agents , which are widely used for pain relief after cesarean section , provide suboptimal analgesia with occasional serious side effects .", "sentence_id": 0}
+{"abstract_id": "24529671", "label": "objective", "text": "We designed a randomized , double-blind , placebo-controlled study to evaluate the analgesic efficacy of intrathecal ketamine added to bupivacaine after cesarean section .", "sentence_id": 1}
+{"abstract_id": "24529671", "label": "methods", "text": "Sixty patients scheduled for cesarean section under spinal anesthesia were randomly allocated to one of the two groups to receive either bupivacaine @ mg combined with @ mg/kg ketamine , or bupivacaine @ mg combined with @ mL distilled water intrathecally .", "sentence_id": 2}
+{"abstract_id": "24529671", "label": "methods", "text": "The time to the first analgesic request , analgesic requirement in the first @ hours after surgery , onset times of sensory and motor blockades , the durations of sensory and motor blockades , and the incidences of adverse effects such as hypotension , ephedrine requirement , bradycardia , and hypoxemia , were recorded .", "sentence_id": 3}
+{"abstract_id": "24529671", "label": "results", "text": "Patients who received ketamine had a significantly prolonged duration of anesthesia compared with those who did not in the control group -LSB- @ % confidence intervals ( CI ) @-@ ; p = @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "24529671", "label": "results", "text": "The mean time to the first analgesic request was also significantly longer in ketamine group ( @ % CI @-@ ; p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24529671", "label": "results", "text": "The total analgesic consumption in the @ hours following surgery significantly lessened in the ketamine group compared with that of the control group ( @ % CI @-@ @ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24529671", "label": "results", "text": "The two groups did not differ significantly in intraoperative and postoperative side effects .", "sentence_id": 7}
+{"abstract_id": "24529671", "label": "conclusions", "text": "Intrathecal ketamine @ mg/kg co-administered with spinal bupivacaine elongated the time to the first analgesic request and lessened the total analgesic consumption in the first @ postoperative hours in comparison with bupivacaine alone in the control group following elective cesarean delivery .", "sentence_id": 8}
+{"abstract_id": "25349316", "label": "objective", "text": "To measure the effects of participating in structured oral presentation evaluation sessions early in pediatric clerkships on students ' subsequent presentations .", "sentence_id": 0}
+{"abstract_id": "25349316", "label": "methods", "text": "We conducted a single-blind , @-arm , cluster randomized controlled trial during pediatric clerkships at Boston University School of Medicine , University of Maryland School of Medicine , Oregon Health & Science University , and Case Western Reserve University School of Medicine .", "sentence_id": 1}
+{"abstract_id": "25349316", "label": "methods", "text": "Blocks of students at each school were randomly assigned to experience either ( @ ) no formal presentation feedback ( control ) or a small-group presentation feedback session early in pediatric clerkships in which students gave live presentations and received feedback from faculty who rated their presentations by using a ( @ ) single-item ( simple ) or ( @ ) @-item ( detailed ) evaluation form .", "sentence_id": 2}
+{"abstract_id": "25349316", "label": "methods", "text": "At the clerkship end , overall quality of subjects ' presentations was rated by faculty blinded to randomization status , and subjects reported whether their presentations had improved .", "sentence_id": 3}
+{"abstract_id": "25349316", "label": "methods", "text": "Analyses included multivariable linear and logistic regressions clustered on clerkship block that controlled for medical school .", "sentence_id": 4}
+{"abstract_id": "25349316", "label": "results", "text": "A total of @ participants were evenly divided into the @ arms , which had similar characteristics .", "sentence_id": 5}
+{"abstract_id": "25349316", "label": "results", "text": "Compared with controls , presentation quality was significantly associated with participating in detailed ( coefficient : @ ; @ % confidence interval -LSB- CI -RSB- : @-@ @ ) but not simple ( coefficient : @ ; @ % CI : -@ -@ ) feedback sessions .", "sentence_id": 6}
+{"abstract_id": "25349316", "label": "results", "text": "Similarly , student self-report of presentation improvement was significantly associated with participating in detailed ( odds ratio : @ ; @ % CI : @-@ @ -RSB- but not simple ( odds ratio : @ ; @ % CI : @-@ @ ) feedback sessions .", "sentence_id": 7}
+{"abstract_id": "25349316", "label": "conclusions", "text": "Small-group presentation feedback sessions led by faculty using a detailed evaluation form resulted in clerkship students delivering oral presentations of higher quality compared with controls .", "sentence_id": 8}
+{"abstract_id": "24712684", "label": "background", "text": "Stroke is a major cause of death and disability in the world , and the prevalence of stroke tends to increase with age .", "sentence_id": 0}
+{"abstract_id": "24712684", "label": "background", "text": "Despite advances in acute care and secondary preventive strategies , primary prevention should play the most significant role in the reduction of the burden of stroke .", "sentence_id": 1}
+{"abstract_id": "24712684", "label": "background", "text": "As an important component of traditional Chinese Qigong , Baduanjin exercise is a simple , safe exercise , especially suitable for older adults .", "sentence_id": 2}
+{"abstract_id": "24712684", "label": "background", "text": "However , current evidence is insufficient to inform the use of Baduanjin exercise in the prevention of stroke.The aim of this trail is to systematically evaluate the prevention effect of Baduanjin exercise on ischemic stroke in the community elder population with high risk factors .", "sentence_id": 3}
+{"abstract_id": "24712684", "label": "methods", "text": "A total of @ eligible participants from the community elder population will be randomly allocated into the Baduanjin exercise group and usual physical activity control group in a @:@ ratio .", "sentence_id": 4}
+{"abstract_id": "24712684", "label": "methods", "text": "Besides usual physical activity , participants in the Baduanjin exercise group will accept a @-week Baduanjin exercise training with a frequency of five days a week and @ minutes a day .", "sentence_id": 5}
+{"abstract_id": "24712684", "label": "methods", "text": "Primary and secondary outcomes will be measured at baseline , @ weeks ( at end of intervention ) and @ weeks ( after additional @-week follow-up period ) .", "sentence_id": 6}
+{"abstract_id": "24712684", "label": "conclusions", "text": "This study will be the randomized trial to evaluate the effectiveness of Baduanjin exercise for primary prevention of stroke in community elder population with high risk factors of stroke .", "sentence_id": 7}
+{"abstract_id": "24712684", "label": "conclusions", "text": "The results of this trial will help to establish the optimal approach for primary prevention of stroke .", "sentence_id": 8}
+{"abstract_id": "25395354", "label": "background", "text": "Oak moss absolute , an extract from the lichen Evernia prunastri , is a valued perfume ingredient but contains extreme allergens .", "sentence_id": 0}
+{"abstract_id": "25395354", "label": "objective", "text": "To compare the elicitation properties of two preparations of oak moss absolute : ` classic oak moss ' , the historically used preparation , and ` new oak moss ' , with reduced contents of the major allergens atranol and chloroatranol .", "sentence_id": 1}
+{"abstract_id": "25395354", "label": "methods", "text": "The two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in @ oak moss-sensitive volunteers and @ non-allergic control subjects .", "sentence_id": 2}
+{"abstract_id": "25395354", "label": "results", "text": "In both test models , new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss .", "sentence_id": 3}
+{"abstract_id": "25395354", "label": "results", "text": "The control subjects did not react to either of the preparations .", "sentence_id": 4}
+{"abstract_id": "25395354", "label": "conclusions", "text": "New oak moss is still a fragrance allergen , but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals , suggesting that new oak moss is less allergenic to non-sensitized individuals .", "sentence_id": 5}
+{"abstract_id": "24239202", "label": "objective", "text": "This study sought to evaluate the long-term safety and efficacy of everolimus-eluting stents ( EES ) and paclitaxel-eluting stents ( PES ) in patients with obstructive coronary artery disease .", "sentence_id": 0}
+{"abstract_id": "24239202", "label": "background", "text": "The use of EES compared to PES has been shown to result in improved clinical outcomes in patients undergoing PCI .", "sentence_id": 1}
+{"abstract_id": "24239202", "label": "background", "text": "However , there have been concerns regarding the durability of these benefits over longer-term follow-up .", "sentence_id": 2}
+{"abstract_id": "24239202", "label": "methods", "text": "SPIRIT III was a prospective , multicenter trial in which @,@ patients were randomized @:@ to EES versus PES .", "sentence_id": 3}
+{"abstract_id": "24239202", "label": "methods", "text": "Endpoints included ischemia-driven target vessel failure ( TVF ) ( death , myocardial infarction ( MI ) , or ischemia-driven target vessel revascularization -LSB- TVR -RSB- ) , the pre-specified primary endpoint ) , target lesion failure ( TLF ) ( cardiac death , target-vessel MI , or ischemia-driven target lesion revascularization -LSB- TLR -RSB- ) , major adverse cardiac events ( MACE ) ( cardiac death , MI , or ischemia-driven TLR ) , their individual components and stent thrombosis .", "sentence_id": 4}
+{"abstract_id": "24239202", "label": "results", "text": "Five-year follow-up was available in @ % of patients .", "sentence_id": 5}
+{"abstract_id": "24239202", "label": "results", "text": "Treatment with EES versus PES resulted in lower @-year Kaplan-Meier rates of TVF ( @ % vs. @ % , p = @ ) , TLF ( @ % vs. @ % , p = @ ) , and MACE ( @ % vs. @ % , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24239202", "label": "results", "text": "EES also resulted in reduced rates of all-cause death ( @ % vs. @ % , p = @ ) , with nonsignificantly different rates of MI , stent thrombosis , and TLR , and no evidence of late catch-up of TLR over time .", "sentence_id": 7}
+{"abstract_id": "24239202", "label": "conclusions", "text": "At @ years after treatment , EES compared to PES resulted in durable benefits in composite safety and efficacy measures as well as all-cause mortality .", "sentence_id": 8}
+{"abstract_id": "24239202", "label": "conclusions", "text": "Additionally , the absolute difference in TLR between devices remained stable over time without deterioration of effect during late follow-up .", "sentence_id": 9}
+{"abstract_id": "24439655", "label": "background", "text": "Neuropeptide S Receptor ( NPSR@ ) gene has been associated with multiple allergic phenotypes in several patient populations .", "sentence_id": 0}
+{"abstract_id": "24439655", "label": "objective", "text": "We analysed the effect of the NPSR@ genotypes in the development of asthma , rhinitis , eczema , or food allergy in children randomly receiving either probiotic or placebo treatment .", "sentence_id": 1}
+{"abstract_id": "24439655", "label": "methods", "text": "@ children born to families at high risk for allergic diseases were examined by a paediatrician at the age of three months , six months , two years , and five years .", "sentence_id": 2}
+{"abstract_id": "24439655", "label": "methods", "text": "Asthma , rhinitis , eczema , and food allergy were diagnosed according to international guidelines .", "sentence_id": 3}
+{"abstract_id": "24439655", "label": "methods", "text": "Treatment with probiotics ( double-blinded and placebo controlled ) was begun with mothers at @ weeks of gestation age and continued after the birth of infants up to the age of six months .", "sentence_id": 4}
+{"abstract_id": "24439655", "label": "methods", "text": "Association and additive inheritance models were used in genetic analyses .", "sentence_id": 5}
+{"abstract_id": "24439655", "label": "results", "text": "Distribution of the hopo@ was suggestive in the group of patients with atopic eczema at two years .", "sentence_id": 6}
+{"abstract_id": "24439655", "label": "results", "text": "The hopo@_G was found more often in those with eczema in the placebo group ( p = @ , after Bonferroni correction ) and the hopo@_A was found more often in those with eczema and probiotics compared to those with eczema and placebo treatment .", "sentence_id": 7}
+{"abstract_id": "24439655", "label": "results", "text": "None of the NPSR@ tagging SNPs was associated with asthma , IgE-mediated asthma , or sensitisation .", "sentence_id": 8}
+{"abstract_id": "24439655", "label": "results", "text": "Allergic disease in both parents doubled the risk for IgE-mediated allergic disease ( OR @ ) .", "sentence_id": 9}
+{"abstract_id": "24439655", "label": "conclusions", "text": "The NPSR@ gene SNP hopo@ showed a suggestive association for high IgE-associated atopic eczema at two years .", "sentence_id": 10}
+{"abstract_id": "25471907", "label": "background", "text": "Abundant literature regarding the use of intravenous tranexamic acid ( TXA ) in primary total knee replacement is available .", "sentence_id": 0}
+{"abstract_id": "25471907", "label": "background", "text": "Randomized controlled trials have confirmed the efficacy of topical TXA compared with placebo , but the comparison between topical and intravenous TXA is unclear .", "sentence_id": 1}
+{"abstract_id": "25471907", "label": "background", "text": "The present study was designed to verify noninferior efficacy and safety of topical intra-articular TXA compared with intravenous TXA in primary total knee replacement with cemented implants .", "sentence_id": 2}
+{"abstract_id": "25471907", "label": "methods", "text": "A Phase-III , single-center , double-blind , randomized , controlled clinical trial was performed to compare topical intra-articular TXA ( @ g of TXA in @ mL of physiological saline solution ) with two intravenous doses of TXA ( @ mg/kg in @ mL of physiological saline solution , one dose before tourniquet release and another three hours after surgery ) in a multimodal protocol for blood loss prevention .", "sentence_id": 3}
+{"abstract_id": "25471907", "label": "methods", "text": "The primary outcome was the blood transfusion rate , and the secondary outcomes included visible blood loss ( as measured in the drain ) at twenty-four hours postoperatively and invisible blood loss ( as estimated from the Nadler formula ) at forty-eight hours postoperatively .", "sentence_id": 4}
+{"abstract_id": "25471907", "label": "methods", "text": "The sample size of seventy-eight patients was calculated to give a statistical power of @ % for demonstrating noninferiority .", "sentence_id": 5}
+{"abstract_id": "25471907", "label": "methods", "text": "Thirty-nine patients each were allocated to receive topical intra-articular TXA ( the experimental group ) and intravenous TXA ( the control group ) ; there were no significant differences in demographics or preoperative laboratory values between the groups .", "sentence_id": 6}
+{"abstract_id": "25471907", "label": "methods", "text": "Noninferiority was estimated by comparing the confidence intervals with a delta of @ % .", "sentence_id": 7}
+{"abstract_id": "25471907", "label": "methods", "text": "Student t and Mann-Whitney tests were used to assess the significance of any differences .", "sentence_id": 8}
+{"abstract_id": "25471907", "label": "results", "text": "The transfusion rate was zero in both groups ; thus , noninferiority was demonstrated for the primary efficacy end point , suggesting equivalence .", "sentence_id": 9}
+{"abstract_id": "25471907", "label": "results", "text": "Noninferiority was also demonstrated for the secondary efficacy end points .", "sentence_id": 10}
+{"abstract_id": "25471907", "label": "results", "text": "Drain blood loss at twenty-four hours was @ mL ( @ % confidence interval -LSB- CI -RSB- , @ to @ mL ) in the experimental group and @ mL ( @ % CI , @ to @ mL ) in the control group ( p = @ , Mann-Whitney ) .", "sentence_id": 11}
+{"abstract_id": "25471907", "label": "results", "text": "Also , estimated blood loss at forty-eight hours was @ mL ( @ % CI , @ to @ mL ) in the experimental group and @ mL ( @ % CI , @ to @ mL ) in the control group ( p = @ , Mann-Whitney ) .", "sentence_id": 12}
+{"abstract_id": "25471907", "label": "results", "text": "No significant safety differences were seen between groups .", "sentence_id": 13}
+{"abstract_id": "25471907", "label": "conclusions", "text": "Topical administration of TXA according to the described protocol demonstrated noninferiority compared with intravenous TXA , with no safety concerns .", "sentence_id": 14}
+{"abstract_id": "25471907", "label": "conclusions", "text": "This randomized controlled trial supports the topical intra-articular administration of TXA in primary total knee replacement with cemented implants .", "sentence_id": 15}
+{"abstract_id": "25471907", "label": "methods", "text": "Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence .", "sentence_id": 16}
+{"abstract_id": "26385950", "label": "background", "text": "Nutritional anemia is a public health problem among Ghanaian schoolchildren .", "sentence_id": 0}
+{"abstract_id": "26385950", "label": "background", "text": "There is need to employ dietary modification strategies to solve this problem through school and household feeding programs .", "sentence_id": 1}
+{"abstract_id": "26385950", "label": "objective", "text": "To evaluate the effectiveness of cowpea-based food containing fish meal served with vitamin C-rich drink to improve iron stores and hemoglobin concentrations in Ghanaian schoolchildren .", "sentence_id": 2}
+{"abstract_id": "26385950", "label": "methods", "text": "The study involved cross-sectional baseline and nutrition intervention phases .", "sentence_id": 3}
+{"abstract_id": "26385950", "label": "methods", "text": "There were @ participants of age @ to @ years .", "sentence_id": 4}
+{"abstract_id": "26385950", "label": "methods", "text": "They were randomly assigned to @ groups , fish meal - vitamin C ( n = @ ) , vitamin C ( n = @ ) , and control ( n = @ ) , and given different cowpea-based diets for a @-month period .", "sentence_id": 5}
+{"abstract_id": "26385950", "label": "methods", "text": "Height and weight measurements were done according to the standard procedures , dietary data were obtained by @-hour recall and food frequency questionnaire , hemoglobin concentrations were determined by Hemocue Hemoglobinometer , and serum ferritin and complement-reactive protein ( CRP ) were determined by enzyme-linked immunosorbent assay .", "sentence_id": 6}
+{"abstract_id": "26385950", "label": "methods", "text": "Participants ' blood samples were examined for malaria parasitemia and stools for helminthes using Giemsa stain and Kato-Katz techniques , respectively .", "sentence_id": 7}
+{"abstract_id": "26385950", "label": "results", "text": "Mean ferritin concentration was not significantly different among groups .", "sentence_id": 8}
+{"abstract_id": "26385950", "label": "results", "text": "End line mean or change in hemoglobin concentrations between fish meal-vitamin C group ( @ @ / @ @ g/L ) and control ( @ @ / @ @ g/L ) were different , P < @ .", "sentence_id": 9}
+{"abstract_id": "26385950", "label": "results", "text": "Change in prevalence of anemia in fish meal-vitamin C group ( @ % ) was different compared to those of vitamin C group ( @ % ) and the control ( @ % ) .", "sentence_id": 10}
+{"abstract_id": "26385950", "label": "results", "text": "Levels of malaria parasitemia and high CRP among study participants at baseline and end line were @ % and @ % then @ % and @ % , respectively .", "sentence_id": 11}
+{"abstract_id": "26385950", "label": "results", "text": "Level of hookworm infestation was @ % .", "sentence_id": 12}
+{"abstract_id": "26385950", "label": "conclusions", "text": "Cowpea-based food containing @ % fish meal and served with vitamin C-rich drink improved hemoglobin concentration and minimized the prevalence of anemia among the study participants .", "sentence_id": 13}
+{"abstract_id": "25444575", "label": "background", "text": "Mild cognitive impairment ( MCI ) increases dementia risk with no pharmacologic treatment available .", "sentence_id": 0}
+{"abstract_id": "25444575", "label": "methods", "text": "The Study of Mental and Resistance Training was a randomized , double-blind , double-sham controlled trial of adults with MCI .", "sentence_id": 1}
+{"abstract_id": "25444575", "label": "methods", "text": "Participants were randomized to @ supervised interventions : active or sham physical training ( high intensity progressive resistance training vs seated calisthenics ) plus active or sham cognitive training ( computerized , multidomain cognitive training vs watching videos/quizzes ) , @-@ days/week for @ months with @-month follow-up .", "sentence_id": 2}
+{"abstract_id": "25444575", "label": "methods", "text": "Primary outcomes were global cognitive function ( Alzheimer 's Disease Assessment Scale-cognitive subscale ; ADAS-Cog ) and functional independence ( Bayer Activities of Daily Living ) .", "sentence_id": 3}
+{"abstract_id": "25444575", "label": "methods", "text": "Secondary outcomes included executive function , memory , and speed/attention tests , and cognitive domain scores .", "sentence_id": 4}
+{"abstract_id": "25444575", "label": "results", "text": "One hundred adults with MCI -LSB- @ ( @ ) years ; @ % women -RSB- were enrolled and analyzed .", "sentence_id": 5}
+{"abstract_id": "25444575", "label": "results", "text": "Resistance training significantly improved the primary outcome ADAS-Cog ; -LSB- relative effect size ( @ % confidence interval ) -@ ( -@ , @ ) ; P < @ -RSB- at @ months and executive function ( Wechsler Adult Intelligence Scale Matrices ; P = @ ) across @ months .", "sentence_id": 6}
+{"abstract_id": "25444575", "label": "results", "text": "Normal ADAS-Cog scores occurred in @ % ( @/@ ) after resistance training vs @ % ( @/@ ) without resistance training -LSB- P < @ ; odds ratio ( @ % confidence interval ) @ ( @ , @ ) -RSB- .", "sentence_id": 7}
+{"abstract_id": "25444575", "label": "results", "text": "Cognitive training only attenuated decline in Memory Domain at @ months ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25444575", "label": "results", "text": "Resistance training @-month benefit was @ % higher ( P = @ ) for Executive Domain compared with combined training -LSB- z-score change = @ ( @ , @ ) resistance training vs @ ( -@ , @ ) combined -RSB- and @ % higher ( P < @ ) for Global Domain -LSB- z-score change = @ ( @ , @ ) resistance training vs @ ( @ , @ ) combined -RSB- .", "sentence_id": 9}
+{"abstract_id": "25444575", "label": "conclusions", "text": "Resistance training significantly improved global cognitive function , with maintenance of executive and global benefits over @ months .", "sentence_id": 10}
+{"abstract_id": "25027552", "label": "background", "text": "We performed a randomized , non-comparative phase II study evaluating docetaxel in combination with either daily continuous ( protracted IV ) @-fluorouracil or cisplatin administered weekly , concurrent to radiotherapy in the treatment of locally advanced pancreatic carcinoma .", "sentence_id": 0}
+{"abstract_id": "25027552", "label": "background", "text": "Results of the docetaxel plus cisplatin regimen are reported .", "sentence_id": 1}
+{"abstract_id": "25027552", "label": "methods", "text": "Forty chemotherapy-naive patients with locally advanced pancreatic carcinoma were randomly assigned to receive @-fluorouracil and docetaxel or docetaxel @mg/m ( @ ) and cisplatin @mg/m ( @ ) / week , plus concurrent radiotherapy for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25027552", "label": "methods", "text": "The radiation dose to the primary tumour was @Gy in @ fractions .", "sentence_id": 3}
+{"abstract_id": "25027552", "label": "methods", "text": "The trial 's primary endpoint was the @-month crude non-progression rate .", "sentence_id": 4}
+{"abstract_id": "25027552", "label": "results", "text": "@ patients from @ centres were included in the docetaxel-cisplatin treatment group .", "sentence_id": 5}
+{"abstract_id": "25027552", "label": "results", "text": "Six-month non-progression rate was @ % ( @ % confidence interval : @-@ ) .", "sentence_id": 6}
+{"abstract_id": "25027552", "label": "results", "text": "Median overall survival was @ months ( @ % confidence interval : @-@ @ ) ; @ complete and @ partial responses were obtained .", "sentence_id": 7}
+{"abstract_id": "25027552", "label": "results", "text": "Six patients survived more than @ years after their inclusion in the trial .", "sentence_id": 8}
+{"abstract_id": "25027552", "label": "results", "text": "Grade @ toxicity was reported in @ % of patients ; no treatment-related death occurred .", "sentence_id": 9}
+{"abstract_id": "25027552", "label": "results", "text": "Severe toxicities were mainly anorexia ( @ % ) , vomiting ( @ % ) and fatigue ( @ % ) .", "sentence_id": 10}
+{"abstract_id": "25027552", "label": "conclusions", "text": "Despite inadequate efficacy according to the main end point , this regimen gave a satisfactory rate of objective response ( @ % ) with tolerable toxicity .", "sentence_id": 11}
+{"abstract_id": "24911076", "label": "background", "text": "Recombinant granulocyte colony-stimulating factor ( G-CSF ) is widely used to mobilize haematopoietic stem cells .", "sentence_id": 0}
+{"abstract_id": "24911076", "label": "background", "text": "We compared the efficacy and safety of a biosimilar G-CSF ( Zarzio ( ) , Sandoz Biopharmaceuticals ) with the originator G-CSF ( Neupogen ( ) , Amgen ) in patients with haematological malignancies .", "sentence_id": 1}
+{"abstract_id": "24911076", "label": "methods", "text": "A total of @ patients were included in this study , @ of whom were female ( @ male ) , with an overall median age of @ years ( range @-@ ) .", "sentence_id": 2}
+{"abstract_id": "24911076", "label": "methods", "text": "Patients had multiple myeloma ( n = @ ) , non-Hodgkin 's lymphoma ( n = @ ) , Hodgkin 's lymphoma ( n = @ ) , or other diagnosis ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24911076", "label": "methods", "text": "After administration of mobilizing regimens ( primarily high-dose etoposide , high-dose cyclophosphamide , intermediate-dose Ara-C or ESHAP ) , patients were randomized to a standard daily @ g/kg dose of biosimilar G-CSF ( n = @ ) or originator G-CSF ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24911076", "label": "results", "text": "Median duration of G-CSF administration was @ days with both biosimilar G-CSF ( range @-@ ) and originator G-CSF ( range @-@ ) .", "sentence_id": 5}
+{"abstract_id": "24911076", "label": "results", "text": "Both groups had a median of one apheresis with a median time until first apheresis of @ days .", "sentence_id": 6}
+{"abstract_id": "24911076", "label": "results", "text": "There were no statistically significant differences between groups in the mean SD number of mobilized CD@ + cells/L in peripheral blood or the number of CD@ + cells/kg body weight .", "sentence_id": 7}
+{"abstract_id": "24911076", "label": "results", "text": "Five patients ( @ % ) in the originator G-CSF group and six patients in the biosimilar G-CSF group ( @ % ) did not mobilize sufficient CD@ + cells .", "sentence_id": 8}
+{"abstract_id": "24911076", "label": "results", "text": "The adverse event profile was similar between groups .", "sentence_id": 9}
+{"abstract_id": "24911076", "label": "conclusions", "text": "A biosimilar G-CSF ( Zarzio ( ) ) demonstrated similar efficacy and safety as the reference originator G-CSF ( Neupogen ( ) ) in hematopoietic stem cell mobilization in patients with haematological malignancies .", "sentence_id": 10}
+{"abstract_id": "24369433", "label": "background", "text": "The standardized patient approach has proved to be an effective training tool for medical educators .", "sentence_id": 0}
+{"abstract_id": "24369433", "label": "background", "text": "This article explains the process of employing standardized patients in an HIV stigma reduction intervention in healthcare settings in China .", "sentence_id": 1}
+{"abstract_id": "24369433", "label": "methods", "text": "The study was conducted in @ hospitals in two provinces of China .", "sentence_id": 2}
+{"abstract_id": "24369433", "label": "methods", "text": "One year after the stigma reduction intervention , standardized patients made unannounced visits to participating hospitals , randomly approached service providers on duty and presented symptoms related to HIV and disclosed HIV-positive test results .", "sentence_id": 3}
+{"abstract_id": "24369433", "label": "methods", "text": "After each visit , the standardized patients evaluated their providers ' attitudes and behaviours using a structured checklist .", "sentence_id": 4}
+{"abstract_id": "24369433", "label": "methods", "text": "Standardized patients also took open-ended observation notes about their experience and the evaluation process .", "sentence_id": 5}
+{"abstract_id": "24369433", "label": "results", "text": "Seven standardized patients conducted a total of @ assessments ( @ from @ hospitals in the intervention condition ; @ from @ hospitals in the control condition ) .", "sentence_id": 6}
+{"abstract_id": "24369433", "label": "results", "text": "Based on a comparative analysis , the intervention hospitals received a better rating than the control hospitals in terms of general impression and universal precaution compliance as well as a lower score on stigmatizing attitudes and behaviours toward the standardized patients .", "sentence_id": 7}
+{"abstract_id": "24369433", "label": "conclusions", "text": "Standardized patients are a useful supplement to traditional self-report assessments , particularly for measuring intervention outcomes that are sensitive or prone to social desirability .", "sentence_id": 8}
+{"abstract_id": "25683074", "label": "background", "text": "Anecdotal reports have demonstrated the feasibility of needle aspiration to deflate a distended bowel , but we do not know of any prospective study that has evaluated this technique .", "sentence_id": 0}
+{"abstract_id": "25683074", "label": "background", "text": "We designed a controlled study to evaluate the use of the selective transperitoneal needle aspiration of a bowel loop ( STAB ) in infants .", "sentence_id": 1}
+{"abstract_id": "25683074", "label": "methods", "text": "Candidates were patients of less than @ months of age , scheduled for laparoscopic Nissen fundoplication , in whom severe colonic distension was observed .", "sentence_id": 2}
+{"abstract_id": "25683074", "label": "methods", "text": "We randomized the patients to the study drug or placebo in a @:@ mode .", "sentence_id": 3}
+{"abstract_id": "25683074", "label": "methods", "text": "The treatment group received STAB , whereas the control group was subject to conventional maneuvers .", "sentence_id": 4}
+{"abstract_id": "25683074", "label": "methods", "text": "We performed @ Nissen procedures laparoscopically : @ were in infants @ months old , but only @ presented severe transverse colonic distension .", "sentence_id": 5}
+{"abstract_id": "25683074", "label": "results", "text": "STAB facilitated the surgical procedure and drastically reduced surgical time .", "sentence_id": 6}
+{"abstract_id": "25683074", "label": "results", "text": "Thus , we calculated our sample size with use of the following inputs : @ % power , a critical P value of @ , and @ % reduction in surgical time .", "sentence_id": 7}
+{"abstract_id": "25683074", "label": "results", "text": "This resulted in a necessary sample size of @ subjects per group , for a total required sample size of @ subjects .", "sentence_id": 8}
+{"abstract_id": "25683074", "label": "results", "text": "STAB procedures were done in @ patients , and conventional measures were used in @ .", "sentence_id": 9}
+{"abstract_id": "25683074", "label": "results", "text": "STAB was attempted a total of @ times .", "sentence_id": 10}
+{"abstract_id": "25683074", "label": "results", "text": "Mean operative time was shorter in the STAB group .", "sentence_id": 11}
+{"abstract_id": "25683074", "label": "conclusions", "text": "We propose the use of STAB as alternative therapy to decompress a dilated large-bowel loop during laparoscopic surgery .", "sentence_id": 12}
+{"abstract_id": "25683074", "label": "conclusions", "text": "This maneuver is simple and efficient and has no clinical complications .", "sentence_id": 13}
+{"abstract_id": "25683074", "label": "conclusions", "text": "Future studies are required to evaluate its role in the subset of other patients or procedures .", "sentence_id": 14}
+{"abstract_id": "24368867", "label": "background", "text": "The traditional oxygen delivery methods for oxygen therapy are continuous flow oxygen ( CFO ) and demand oxygen delivery ( DOD ) ; however , oxygen waste is considerable in CFO , while DOD is uncomfortable for patients .", "sentence_id": 0}
+{"abstract_id": "24368867", "label": "background", "text": "Synchronized DOD ( SDOD ) , which was designed to overcome the drawbacks of both CFO and DOD , supplies oxygen according to the patient 's breathing pattern and the desired oxygen saving .", "sentence_id": 1}
+{"abstract_id": "24368867", "label": "background", "text": "This study was conducted to examine the overall performance of SDOD in terms of oxygen saturation ( SpO@ ) , patients ' comfort , and oxygen saving ratio ( SR ) .", "sentence_id": 2}
+{"abstract_id": "24368867", "label": "methods", "text": "Study subjects were patients who required oxygen for COPD or pneumonia .", "sentence_id": 3}
+{"abstract_id": "24368867", "label": "methods", "text": "Patients received oxygen through nasal prongs by CFO and SDOD for @ min each .", "sentence_id": 4}
+{"abstract_id": "24368867", "label": "methods", "text": "SpO@ was measured every @ min by pulse oximetry , and subjects recorded their level of comfort after @ min .", "sentence_id": 5}
+{"abstract_id": "24368867", "label": "methods", "text": "The flow of discharged oxygen was recorded to calculate SR. .", "sentence_id": 6}
+{"abstract_id": "24368867", "label": "results", "text": "Ten subjects ( median age , @ y ; range , @-@ y ) were enrolled .", "sentence_id": 7}
+{"abstract_id": "24368867", "label": "results", "text": "The SpO@ of patients during SDOD ( @ @ % ) was similar to that during CFO ( @ @ % ) with no statistically significant difference ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24368867", "label": "results", "text": "Subjects reported SDOD to be more comfortable than CFO .", "sentence_id": 9}
+{"abstract_id": "24368867", "label": "results", "text": "The comfort score of subjects treated with SDOD was @ @ ( @ : very uncomfortable , @ : very comfortable ) ; this was significantly higher ( P = @ ) than the comfort score ( @ @ ) of subjects treated with CFO .", "sentence_id": 10}
+{"abstract_id": "24368867", "label": "results", "text": "The SR values set by clinicians were very similar to calculated SR values .", "sentence_id": 11}
+{"abstract_id": "24368867", "label": "conclusions", "text": "SDOD appears to be more suitable for oxygen therapy than CFO when considering SpO@ , patients ' comfort , and SR. .", "sentence_id": 12}
+{"abstract_id": "25833784", "label": "background", "text": "In Haiti and other countries , large-scale investments in school feeding programs have been made with marginal evidence of nutrition outcomes .", "sentence_id": 0}
+{"abstract_id": "25833784", "label": "objective", "text": "We aimed to examine the effectiveness of a fortified ready-to-use supplementary food ( RUSF ) , Mamba , on reduced anemia and improved body composition in school-aged children compared to an unfortified cereal bar , Tablet Yo , and control groups .", "sentence_id": 1}
+{"abstract_id": "25833784", "label": "methods", "text": "A cluster , randomized trial with children ages @-@ y ( n = @ ) was conducted in the north of Haiti .", "sentence_id": 2}
+{"abstract_id": "25833784", "label": "methods", "text": "Six schools were matched and randomized to the control group , Tablet Yo group ( @ g , @ kcal ) , or Mamba group ( @ g , @ kcal , and > @ % of the RDA for critical micronutrients ) .", "sentence_id": 3}
+{"abstract_id": "25833784", "label": "methods", "text": "Children in the supplementation groups received the snack daily for @ d , and all were followed longitudinally for hemoglobin concentrations , anthropometry , and bioelectrical impedance measures : baseline ( December @ ) , midline ( March @ ) , and endline ( June @ ) .", "sentence_id": 4}
+{"abstract_id": "25833784", "label": "methods", "text": "Parent surveys were conducted at baseline and endline to examine secondary outcomes of morbidities and dietary intakes .", "sentence_id": 5}
+{"abstract_id": "25833784", "label": "methods", "text": "Longitudinal regression modeling using generalized least squares and logit with random effects tested the main effects .", "sentence_id": 6}
+{"abstract_id": "25833784", "label": "results", "text": "At baseline ,@ % of children were stunted , @ % underweight , @ % thin , and @ % anemic .", "sentence_id": 7}
+{"abstract_id": "25833784", "label": "results", "text": "Fat mass percentage ( mean SD ) was @ % @ % for boys and @ % @ % for girls .", "sentence_id": 8}
+{"abstract_id": "25833784", "label": "results", "text": "In longitudinal modeling , Mamba supplementation increased body mass index z score ( regression coefficient SEE ) @ @ , fat mass @ @ kg , and percentage fat mass @ % @ % compared with control at each time point ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25833784", "label": "results", "text": "Among boys , Mamba increased fat mass ( regression coefficient SEE ) @ @ kg and fat-free mass @ @ kg compared with control ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25833784", "label": "results", "text": "Mamba reduced the odds of developing anemia by @ % compared to control ( adjusted OR : @ ; @ % CI : @ , @ ; P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25833784", "label": "results", "text": "No treatment effect was found for hemoglobin concentration .", "sentence_id": 12}
+{"abstract_id": "25833784", "label": "conclusions", "text": "To our knowledge , this is the first study to give evidence of body composition effects from an RUSF in school-aged children .", "sentence_id": 13}
+{"abstract_id": "24402740", "label": "objective", "text": "To examine the effect of incentive spirometry in pulmonary rehabilitation of chronic obstructive pulmonary disease ( COPD ) patients and compare its efficacy with inspiratory resistive muscle training ( IMT ) technique .", "sentence_id": 0}
+{"abstract_id": "24402740", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24402740", "label": "methods", "text": "Thirty patients with COPD , from a general hospital in Mashhad , Iran , were randomly assigned to two study groups .", "sentence_id": 2}
+{"abstract_id": "24402740", "label": "methods", "text": "All subjects trained daily in two @-minute sessions , @ days a week , for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24402740", "label": "methods", "text": "Respiratory function tests were compared before interventions and at the end of weeks @ and @ .", "sentence_id": 4}
+{"abstract_id": "24402740", "label": "results", "text": "Both techniques improved the mean values of all respiratory function tests ( p. @ ) .", "sentence_id": 5}
+{"abstract_id": "24402740", "label": "results", "text": "The IMT technique was more effective to improve MVV and PImax ( p. @ ) .", "sentence_id": 6}
+{"abstract_id": "24402740", "label": "results", "text": "PEFR was better improved in the incentive spirometry group ( p. @ ) .", "sentence_id": 7}
+{"abstract_id": "24402740", "label": "results", "text": "There was no significant difference for other spirometric parameters between two groups .", "sentence_id": 8}
+{"abstract_id": "24402740", "label": "conclusions", "text": "Incentive spirometry can be considered as an effective component for pulmonary rehabilitation in COPD patients .", "sentence_id": 9}
+{"abstract_id": "25638011", "label": "objective", "text": "Secukinumab , a fully human anti-interleukin-@A monoclonal antibody , exhibited promising activity in a proof-of-concept study when administered in intravenous ( IV ) doses to patients with active , chronic , noninfectious uveitis .", "sentence_id": 0}
+{"abstract_id": "25638011", "label": "objective", "text": "This study compared the efficacy and safety of different IV and subcutaneous ( SC ) doses of secukinumab in patients with noninfectious uveitis .", "sentence_id": 1}
+{"abstract_id": "25638011", "label": "methods", "text": "Multicenter , randomized , double-masked , dose-ranging , phase @ clinical trial .", "sentence_id": 2}
+{"abstract_id": "25638011", "label": "methods", "text": "Thirty-seven patients with active noninfectious intermediate uveitis , posterior uveitis , or panuveitis who required corticosteroid-sparing immunosuppressive therapy .", "sentence_id": 3}
+{"abstract_id": "25638011", "label": "methods", "text": "Patients were randomized to secukinumab @ mg SC every @ weeks for @ doses , secukinumab @ mg/kg IV every @ weeks for @ doses , or secukinumab @ mg/kg IV every @ weeks for @ doses .", "sentence_id": 4}
+{"abstract_id": "25638011", "label": "methods", "text": "Intravenous or SC saline was administered to maintain masking .", "sentence_id": 5}
+{"abstract_id": "25638011", "label": "methods", "text": "Efficacy was assessed on day @ ( @-@ weeks after last dose ) .", "sentence_id": 6}
+{"abstract_id": "25638011", "label": "methods", "text": "Percentage of patients with treatment response , defined as ( @ ) at least a @-grade reduction in vitreous haze score or trace or absent vitreous haze in the study eye without an increase in corticosteroid dose and without uveitis worsening or ( @ ) reduction in corticosteroid dosages to prespecified levels without uveitis worsening .", "sentence_id": 7}
+{"abstract_id": "25638011", "label": "methods", "text": "Percentage of patients with remission , defined as anterior chamber cell and vitreous haze scores of @ or @ + in both eyes without corticosteroid therapy or uveitis worsening .", "sentence_id": 8}
+{"abstract_id": "25638011", "label": "results", "text": "Secukinumab @ mg/kg IV and @ mg/kg IV , compared with the @ mg SC dose , produced higher responder rates ( @ % and @ % vs. @ % , respectively ) and remission rates ( @ % and @ % vs. @ % , respectively ) .", "sentence_id": 9}
+{"abstract_id": "25638011", "label": "results", "text": "Statistical and clinical superiority for the @ mg/kg IV dose compared with the @ mg SC dose was established in a Bayesian probability model .", "sentence_id": 10}
+{"abstract_id": "25638011", "label": "results", "text": "Other measures , including time to response onset , change in visual acuity , and change in vitreous haze score , showed numeric trends favoring IV dosing .", "sentence_id": 11}
+{"abstract_id": "25638011", "label": "results", "text": "Secukinumab , administered in IV or SC formulations , appeared safe and was well tolerated .", "sentence_id": 12}
+{"abstract_id": "25638011", "label": "conclusions", "text": "Intravenous secukinumab was effective and well tolerated in noninfectious uveitis requiring systemic corticosteroid-sparing immunosuppressive therapy .", "sentence_id": 13}
+{"abstract_id": "25638011", "label": "conclusions", "text": "Greater activity with IV dosing suggests that patients may not receive sufficient drug with SC administration .", "sentence_id": 14}
+{"abstract_id": "25638011", "label": "conclusions", "text": "High-dose IV secukinumab may be necessary to deliver secukinumab in therapeutic concentrations .", "sentence_id": 15}
+{"abstract_id": "25151903", "label": "objective", "text": "To explore the effects of walking exercise during late trimester on pregnancy outcome of low-risk primipara .", "sentence_id": 0}
+{"abstract_id": "25151903", "label": "methods", "text": "A prospective randomized controlled study was conducted for @ cases of low-risk primipara who had regular prenatal care at Shengjing Hospital , China Medical University from July @ to June @ .", "sentence_id": 1}
+{"abstract_id": "25151903", "label": "methods", "text": "And informed consent was obtained .", "sentence_id": 2}
+{"abstract_id": "25151903", "label": "methods", "text": "The control group included @ cases of other low-risk primipara in the same period .", "sentence_id": 3}
+{"abstract_id": "25151903", "label": "methods", "text": "Except that the experimental group had regular structured walking exercise from @ weeks of gestational age to delivery , other consulting guidance were the same as the control group .", "sentence_id": 4}
+{"abstract_id": "25151903", "label": "methods", "text": "The inter-group differences , such as delivery mode , mean body weight gain per week after @ weeks of gestation , duration of labor , labor pain perception , neonatal weight and neonatal birth condition , were detected and analyzed .", "sentence_id": 5}
+{"abstract_id": "25151903", "label": "results", "text": "Finally there were @ and @ dropouts in experimental and control groups respectively .", "sentence_id": 6}
+{"abstract_id": "25151903", "label": "results", "text": "For two groups , the rate of caesarean section was @ % and @ % , the mean body weight gain per week after @ weeks of gestational age ( @ @ ) and ( @ @ ) kg , the labor pain score are @ @ and @ @ , the duration of labor ( @ @ ) and ( @ @ ) h , the neonatal birth weight ( @ @ ) and ( @ @ ) kg and the rate of macrosomia @ % and @ % respectively .", "sentence_id": 7}
+{"abstract_id": "25151903", "label": "results", "text": "The differences had statistical significance ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25151903", "label": "results", "text": "The rate of preterm birth was @ % and @ % , the rate of premature rupture of membrane @ % and @ % and the rate of neonatal asphyxia @ % and @ % respectively .", "sentence_id": 9}
+{"abstract_id": "25151903", "label": "results", "text": "The differences had no statistical significance ( all P > @ ) .", "sentence_id": 10}
+{"abstract_id": "25151903", "label": "conclusions", "text": "Simple , safe and effective , walking exercise during late trimester may improve the pregnancy outcomes of low-risk primipara .", "sentence_id": 11}
+{"abstract_id": "25416724", "label": "objective", "text": "Visceral adipose tissue ( VAT ) is associated with an increased risk of metabolic syndrome ( MetS ) .", "sentence_id": 0}
+{"abstract_id": "25416724", "label": "objective", "text": "Recent studies have suggested that VAT negatively affects bone .", "sentence_id": 1}
+{"abstract_id": "25416724", "label": "objective", "text": "However , MetS has also been associated with higher estradiol ( E@ ) levels , which is bone protective .", "sentence_id": 2}
+{"abstract_id": "25416724", "label": "objective", "text": "We therefore investigated the impact of VAT and E@ levels on bone density , structural parameters , and strength estimates .", "sentence_id": 3}
+{"abstract_id": "25416724", "label": "methods", "text": "A cross-sectional study was conducted in @ obese men with MetS to investigate the impact of VAT and E@ levels on bone .", "sentence_id": 4}
+{"abstract_id": "25416724", "label": "methods", "text": "Bone parameters were assessed by dual-energy X-ray absorptiometry ( DXA ) , quantitative computed tomography ( QCT ) , and high-resolution peripheral QCT ( HRpQCT ) at lumbar spine , proximal femur , radius , and tibia .", "sentence_id": 5}
+{"abstract_id": "25416724", "label": "methods", "text": "VAT volume was measured by magnetic resonance imaging ( MRI ) and sexual hormones were measured in blood samples .", "sentence_id": 6}
+{"abstract_id": "25416724", "label": "results", "text": "Men with high VAT had a lower bone density at the hip ( P < @ ) , lower cortical thickness , and higher buckling ratio at femoral neck ( FN ) ( P = @ and P = @ ) , compared with men with low VAT , despite a similar body weight and BMI .", "sentence_id": 7}
+{"abstract_id": "25416724", "label": "results", "text": "Generally , E@ levels were low ( median @pmol/l ) , and men with E@ levels below median had reduced bone density at lumbar spine ( P = @ ) , and impaired structural parameters at radius and tibia , compared with men with E@ levels above median .", "sentence_id": 8}
+{"abstract_id": "25416724", "label": "results", "text": "At the hip , VAT volume and E@ levels affected bone density independently and additively , and @ % of men with high VAT and low E@ levels had osteopenia with significantly lower T-score at FN ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25416724", "label": "conclusions", "text": "High VAT and low E@ negatively affect bone in obese men with MetS .", "sentence_id": 10}
+{"abstract_id": "25416724", "label": "conclusions", "text": "VAT and E@ affect bone density at the hip independently and additively , revealing an unexpected high prevalence of osteopenia in middle-aged men with MetS .", "sentence_id": 11}
+{"abstract_id": "25070960", "label": "objective", "text": "Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process .", "sentence_id": 0}
+{"abstract_id": "25070960", "label": "objective", "text": "We assessed whether Terutroban , a thromboxane prostaglandin receptor antagonist , affects the progression of atherosclerosis , as measured by common carotid intima-media thickness and carotid plaques .", "sentence_id": 1}
+{"abstract_id": "25070960", "label": "methods", "text": "A substudy was performed among @ participants of the aspirin-controlled Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients with a History of Ischemic Stroke or Transient Ischemic Attack ( PERFORM ) trial .", "sentence_id": 2}
+{"abstract_id": "25070960", "label": "methods", "text": "Common carotid intima-media thickness and carotid plaque occurrence was measured during a @-year period .", "sentence_id": 3}
+{"abstract_id": "25070960", "label": "results", "text": "Baseline characteristics did not differ between Terutroban ( n = @ ) and aspirin ( n = @ ) treated patients and were similar as in the main study .", "sentence_id": 4}
+{"abstract_id": "25070960", "label": "results", "text": "Mean study and treatment duration were similar ( @ and @ months , respectively ) .", "sentence_id": 5}
+{"abstract_id": "25070960", "label": "results", "text": "In the Terutroban group , the annualized rate of change in common carotid intima-media thickness was @ mm per year ( @ % confidence interval , -@ to @ ) and -@ mm per year ( @ % confidence interval , -@ to @ ) in the aspirin group .", "sentence_id": 6}
+{"abstract_id": "25070960", "label": "results", "text": "There was no statistically significant difference between the groups in the annualized rate of change of common carotid intima-media thickness ( @ mm per year ; @ % confidence interval , -@ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25070960", "label": "results", "text": "At @ months of follow-up , @ % of Terutroban patients had no emergent plaques , @ % had @ to @ emergent plaques , and @ % had @ emergent plaques .", "sentence_id": 8}
+{"abstract_id": "25070960", "label": "results", "text": "In the aspirin group , the corresponding percentages were @ % , @ % , and @ % .", "sentence_id": 9}
+{"abstract_id": "25070960", "label": "results", "text": "Over time , there was no statistically significant difference in the number of emergent carotid plaques between treatment modalities ( rate ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25070960", "label": "conclusions", "text": "Compared with aspirin , Terutroban did not beneficially affect progression of carotid atherosclerosis among well-treated patients with a history of ischemic stroke or transient ischemic attacks with an internal carotid stenosis < @ % .", "sentence_id": 11}
+{"abstract_id": "24300843", "label": "objective", "text": "The objectives of the study were to evaluate the image quality and diagnostic performance of sinogram-affirmed iterative reconstruction ( SAFIRE ) for detecting hepatic metastasis and to estimate the potential radiation dose reduction at abdominal computed tomography ( CT ) .", "sentence_id": 0}
+{"abstract_id": "24300843", "label": "methods", "text": "Fifty-nine consecutive patients ( mean age , @ years ; range , @-@ years ) who had hepatic metastasis and who underwent dual-source abdominal CT were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "24300843", "label": "methods", "text": "The image noise of the liver was compared between full-dose filtered back projection images ( FD-FBP ) and simulated half-dose images , which used only single-source projection data , and reconstructed with different strengths of SAFIRE ( HD-SAFIRE ( @-@ ) ) by @-way analysis of variance with Bonferroni correction .", "sentence_id": 2}
+{"abstract_id": "24300843", "label": "methods", "text": "The diagnostic performance for hepatic metastasis was compared by logistic regression with the weighted least squares method and noninferiority test between the FD-FBP images and the half-dose sinogram-affirmed iterative reconstruction ( HD-SAFIRE ) images .", "sentence_id": 3}
+{"abstract_id": "24300843", "label": "results", "text": "As the SAFIRE strength increased , image noise decreased ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24300843", "label": "results", "text": "The images of HD-SAFIRE ( @ ) showed similar image noise for liver parenchyma ( @ Hounsfield unit -LSB- HU -RSB- ) , signal-to-noise ratio for liver parenchyma ( @ ) , and lesion-to-liver contrast-to-noise ratio ( @ ) , compared with the FD-FBP images ( @ HU , P = @ ; @ , P > @ ; and @ , P > @ , respectively ) .", "sentence_id": 5}
+{"abstract_id": "24300843", "label": "results", "text": "The diagnostic accuracy for hepatic metastasis with the HD-SAFIRE ( @ ) images ( @ % ) was not different from that of the FD-FBP images ( @ % , P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24300843", "label": "results", "text": "The diagnostic performance of the HD-SAFIRE ( @ ) images was also noninferior to that of the FD-FBP images ( @ % confidence interval lower limit difference -LSB- -@ % -RSB- excluding the -@ % clinical noninferiority limit ) .", "sentence_id": 7}
+{"abstract_id": "24300843", "label": "results", "text": "The mean ( SD ) volume CT dose index of FD-FBP was @ ( @ ) mGy , and the mean ( SD ) radiation dose equivalent associated with HD-SAFIRE was estimated to be @ ( @ ) mGy .", "sentence_id": 8}
+{"abstract_id": "24300843", "label": "conclusions", "text": "By applying SAFIRE@ , the radiation dose could be reduced by up to @ % compared with the standard-of-care abdominal CT protocol without increasing image noise and without deteriorating diagnostic performance for the detection of hepatic metastasis .", "sentence_id": 9}
+{"abstract_id": "24565089", "label": "objective", "text": "Shoulder arthroscopic surgeries evolve with intense postoperative pain .", "sentence_id": 0}
+{"abstract_id": "24565089", "label": "objective", "text": "Several analgesic techniques have been advocated .", "sentence_id": 1}
+{"abstract_id": "24565089", "label": "objective", "text": "The aim of this study was to compare suprascapular and axillary nerve blocks in shoulder arthroscopy using the interscalene approach to brachial plexus blockade .", "sentence_id": 2}
+{"abstract_id": "24565089", "label": "methods", "text": "According to the technique used , sixty-eight patients were allocated into two groups : interscalene group ( IG , n = @ ) and selective group ( SG , n = @ ) , with neurostimulation approach used for both techniques .", "sentence_id": 3}
+{"abstract_id": "24565089", "label": "methods", "text": "After appropriate motor response , IG received @ mL of @ % levobupivacaine in @ % enantiomeric excess with adrenalin @:@,@ .", "sentence_id": 4}
+{"abstract_id": "24565089", "label": "methods", "text": "After motor response of suprascapular and axillary nerves , SG received @ mL of the same substance on each nerve .", "sentence_id": 5}
+{"abstract_id": "24565089", "label": "methods", "text": "General anesthesia was then administered .", "sentence_id": 6}
+{"abstract_id": "24565089", "label": "methods", "text": "Variables assessed were time to perform the blocks , analgesia , opioid consumption , motor block , cardiovascular stability , patient satisfaction and acceptability .", "sentence_id": 7}
+{"abstract_id": "24565089", "label": "results", "text": "Time for interscalene blockade was significantly shorter than for selective blockade .", "sentence_id": 8}
+{"abstract_id": "24565089", "label": "results", "text": "Analgesia was significantly higher in the immediate postoperative period in IG and in the late postoperative period in SG .", "sentence_id": 9}
+{"abstract_id": "24565089", "label": "results", "text": "Morphine consumption was significantly higher in the first hour in SG .", "sentence_id": 10}
+{"abstract_id": "24565089", "label": "results", "text": "Motor block was significantly lower in SG .", "sentence_id": 11}
+{"abstract_id": "24565089", "label": "results", "text": "There was no difference between groups regarding cardiocirculatory stability and patient satisfaction and acceptability .", "sentence_id": 12}
+{"abstract_id": "24565089", "label": "results", "text": "Failure occurred in IG ( @ ) and SG ( @ ) .", "sentence_id": 13}
+{"abstract_id": "24565089", "label": "conclusions", "text": "Both techniques are safe , effective , and with the same degree of satisfaction and acceptability .", "sentence_id": 14}
+{"abstract_id": "24565089", "label": "conclusions", "text": "The selective blockade of both nerves showed satisfactory analgesia , with the advantage of providing motor block restricted to the shoulder .", "sentence_id": 15}
+{"abstract_id": "25152289", "label": "objective", "text": "To explore the effects of pri ming rocuronium on neuromuscular blockade produced by mivacurium .", "sentence_id": 0}
+{"abstract_id": "25152289", "label": "methods", "text": "Ethical approval was granted by the medical ethics committee of our hospital with a reference number of C-@-@-@ .", "sentence_id": 1}
+{"abstract_id": "25152289", "label": "methods", "text": "A total of @ ASA physical status I and II patients undergoing selective otorhinolaryngologic surgery under general anesthesia signed the form of informed consent .", "sentence_id": 2}
+{"abstract_id": "25152289", "label": "methods", "text": "And they were randomly divided by a random number table into @ groups .", "sentence_id": 3}
+{"abstract_id": "25152289", "label": "methods", "text": "After a standardized imidazole-propofol-fentanyl induction , they received a saline placebo injection ( GroupI ) and a pri ming dose of rocuronium @ mg/kg ( GroupII ) , rocuronium @ mg/kg ( Group III ) and rocuronium @ mg/kg ( Group IV ) .", "sentence_id": 4}
+{"abstract_id": "25152289", "label": "methods", "text": "An intubating dose of mivacurium @ mg/kg was offered @ minutes later .", "sentence_id": 5}
+{"abstract_id": "25152289", "label": "methods", "text": "Anesthesia was maintained with propofol and remifentanyl continuous infusion .", "sentence_id": 6}
+{"abstract_id": "25152289", "label": "methods", "text": "Neuromuscular block was monitored with train of four ( TOF ) stimulation .", "sentence_id": 7}
+{"abstract_id": "25152289", "label": "methods", "text": "The onset time , reappearance of T@ ( DUR TOFc @ ) , times of T@ @ % and @ % recovery , recovery index and times of TOF@ % , @ % and @ % recovery were recorded .", "sentence_id": 8}
+{"abstract_id": "25152289", "label": "results", "text": "The onset time of mivacurium was significantly shorter and the times of T@ @ % and @ % recovery were significantly longer in groups of II , III and IV than those in groupI .", "sentence_id": 9}
+{"abstract_id": "25152289", "label": "results", "text": "No significant difference existed in recovery index among @ groups .", "sentence_id": 10}
+{"abstract_id": "25152289", "label": "results", "text": "The onset time of mivacurium became progressively shorter with the growing pri ming dose of rocurium among three experiment groups .", "sentence_id": 11}
+{"abstract_id": "25152289", "label": "results", "text": "And it was not statistically significant .", "sentence_id": 12}
+{"abstract_id": "25152289", "label": "conclusions", "text": "Pri ming rocuronium decreases the onset and intubating times of mivacurium without effect on recovery index .", "sentence_id": 13}
+{"abstract_id": "25152289", "label": "conclusions", "text": "No significant difference exists in drug effect among @ experiment groups .", "sentence_id": 14}
+{"abstract_id": "24934544", "label": "background", "text": "Oxidative stress and inflammation are two key mechanisms suggested to be involved in the pathogenesis of Alzheimer 's disease ( AD ) .", "sentence_id": 0}
+{"abstract_id": "24934544", "label": "background", "text": "Omega-@ fatty acids ( -@ FAs ) found in fish and fish oil have several biological properties that may be beneficial in AD .", "sentence_id": 1}
+{"abstract_id": "24934544", "label": "background", "text": "However , they may also auto-oxidize and induce in vivo lipid peroxidation .", "sentence_id": 2}
+{"abstract_id": "24934544", "label": "objective", "text": "The objective of this study was to evaluate systemic oxidative stress and inflammatory biomarkers following oral supplementation of dietary -@ FA .", "sentence_id": 3}
+{"abstract_id": "24934544", "label": "methods", "text": "Forty patients with moderate AD were randomized to receive @ g DHA ( @:@ ) and @ g EPA ( @:@ ) or placebo for @ months .", "sentence_id": 4}
+{"abstract_id": "24934544", "label": "methods", "text": "Urinary samples were collected before and after supplementation .", "sentence_id": 5}
+{"abstract_id": "24934544", "label": "methods", "text": "The levels of the major F@-isoprostane , @-iso-PGF@ , a consistent in vivo biomarker of oxidative stress , and @-keto-dihydro-PGF@ , a major metabolite of PGF@ and biomarker of inflammatory response , were measured .", "sentence_id": 6}
+{"abstract_id": "24934544", "label": "results", "text": "F@-isoprostane in urine increased in the placebo group after @ months , but there was no clear difference in treatment effect between supplemented and non-supplemented patients on the urinary levels of F@-isoprostanes and @-keto-dihydro-PGF@ .", "sentence_id": 7}
+{"abstract_id": "24934544", "label": "results", "text": "At baseline , the levels of @-keto-dihydro-PGF@ showed negative correlative relationships to -@ FAs , and a positive correlation to linoleic acid .", "sentence_id": 8}
+{"abstract_id": "24934544", "label": "results", "text": "@-iso-PGF@ correlated negatively to the -@ FA arachidonic acid .", "sentence_id": 9}
+{"abstract_id": "24934544", "label": "conclusions", "text": "The findings indicate that supplementation of -@ FAs to patients with AD for @ months does not have a clear effect on free radical-mediated formation of F@-isoprostane or cyclooxygenase-mediated formation of prostaglandin F@ .", "sentence_id": 10}
+{"abstract_id": "24934544", "label": "conclusions", "text": "The correlative relationships to FAs indicate a potential role of FAs in immunoregulation .", "sentence_id": 11}
+{"abstract_id": "24448652", "label": "background", "text": "Morning dose or twice-daily proton pump inhibitor ( PPI ) use is often prescribed to heal severe reflux esophagitis .", "sentence_id": 0}
+{"abstract_id": "24448652", "label": "objective", "text": "Compare the effect of single dose morning ( control arm ) versus nighttime ( experimental arm ) omeprazole/sodium bicarbonate ( Zegerid ( ) ) ( IR-OME ) on esophagitis and gastroesophageal reflux symptoms .", "sentence_id": 1}
+{"abstract_id": "24448652", "label": "methods", "text": "Adult outpatients with Los Angeles grade C or D esophagitis were allocated to open-label @ mg IR-OME once a day for @ weeks in a prospective , randomized , parallel design , single center study .", "sentence_id": 2}
+{"abstract_id": "24448652", "label": "methods", "text": "Esophagogastroduodenoscopy ( EGD ) and validated self-report symptom questionnaires were completed at baseline and follow-up .", "sentence_id": 3}
+{"abstract_id": "24448652", "label": "methods", "text": "Intention-to-treat and per-protocol analyses were performed .", "sentence_id": 4}
+{"abstract_id": "24448652", "label": "results", "text": "Ninety-two of @ ( @ % ) eligible subjects participated -LSB- @ ( @ % ) male , mean age @ ( range @-@ ) , median BMI @ ( range @-@ ) , @ C :@ D -RSB- .", "sentence_id": 5}
+{"abstract_id": "24448652", "label": "results", "text": "Overall , @ ( @ % ) subjects healed -LSB- n = @ ( @ % ) -RSB- or improved -LSB- n = @ ( @ % ) -RSB- erosions .", "sentence_id": 6}
+{"abstract_id": "24448652", "label": "results", "text": "There was no significant difference ( morning vs. night ) in mucosal healing -LSB- @ vs. @ % , ( p = @ ) -RSB- or symptom resolution -LSB- heartburn ( @ vs. @ % , p = @ ) , acid regurgitation ( @ vs. @ % , p = @ ) -RSB- .", "sentence_id": 7}
+{"abstract_id": "24448652", "label": "results", "text": "Prevalence of newly identified Barrett 's esophagus was @ % with half diagnosed only after treatment .", "sentence_id": 8}
+{"abstract_id": "24448652", "label": "conclusions", "text": "Once-daily IR-OME ( taken morning or night ) effectively heals severe reflux esophagitis and improves GERD symptoms .", "sentence_id": 9}
+{"abstract_id": "24448652", "label": "conclusions", "text": "Results support the clinical practice recommendation to repeat EGD after @ weeks PPI therapy in severe esophagitis patients to assure healing and exclude Barrett 's esophagus .", "sentence_id": 10}
+{"abstract_id": "25932701", "label": "background", "text": "Alerts embedded in electronic health records ( EHRs ) are designed to improve processes at the point of care .", "sentence_id": 0}
+{"abstract_id": "25932701", "label": "objective", "text": "The aim of this study was to determine if an EHR alert-at emergency department ( ED ) triage-increases the ED triage nurse 's utilization of triage protocols .", "sentence_id": 1}
+{"abstract_id": "25932701", "label": "methods", "text": "ED triage nurses were randomized to receive either a passive EHR alert or no intervention for patients with the following complaints : minor trauma with extremity injuries or female patients with abdominal pain .", "sentence_id": 2}
+{"abstract_id": "25932701", "label": "methods", "text": "The EHR alert notified the nurse that the patient was eligible for diagnostic testing : radiographs for patients with injured extremities or urinalysis for female patients with abdominal pain .", "sentence_id": 3}
+{"abstract_id": "25932701", "label": "results", "text": "Twenty-eight nurses triaged @,@ patients in the @ months before the intervention and @,@ in the @ months after the intervention .", "sentence_id": 4}
+{"abstract_id": "25932701", "label": "results", "text": "Before the intervention , the urinalysis protocol was implemented in @/@ ( @ % ) patients triaged by the intervention group and @/@ ( @ % ) triaged by the control group .", "sentence_id": 5}
+{"abstract_id": "25932701", "label": "results", "text": "After the intervention , the urinalysis protocol was implemented in @/@ ( @ % ) patients triaged by the intervention group and @/@ ( @ % ) triaged by the control group .", "sentence_id": 6}
+{"abstract_id": "25932701", "label": "results", "text": "Before the intervention , the radiograph protocol was implemented in @/@ ( @ % ) patients triaged by the intervention group and @/@ ( @ % ) triaged by the control group .", "sentence_id": 7}
+{"abstract_id": "25932701", "label": "results", "text": "After the intervention , the radiograph protocol was implemented in @/@ ( @ % ) patients triaged by the intervention group and @/@ ( @ % ) triaged by the control group .", "sentence_id": 8}
+{"abstract_id": "25932701", "label": "conclusions", "text": "The use of a passive EHR alert to promote ED triage protocols showed little benefit .", "sentence_id": 9}
+{"abstract_id": "25932701", "label": "conclusions", "text": "Before the widespread implementation of EHR alerts for patient care , rigorous studies are required to determine the best alert methods and the impacts of such interventions .", "sentence_id": 10}
+{"abstract_id": "26174905", "label": "background", "text": "Hemolysis reaction is a rare class effect of therapy with intravenously administered human normal immunoglobulin ( IVIG ) .", "sentence_id": 0}
+{"abstract_id": "26174905", "label": "background", "text": "Anti-A/B isoagglutinins ( isohemagglutinins ) originating from donor plasma are considered a probable risk factor for hemolysis .", "sentence_id": 1}
+{"abstract_id": "26174905", "label": "background", "text": "We hypothesized that screening and exclusion of plasma obtained from donors with high isoagglutinin titers from the manufacturing process would produce a meaningful reduction of anti-A/B isoagglutinin titers of the final IVIG product .", "sentence_id": 2}
+{"abstract_id": "26174905", "label": "methods", "text": "A donor screening method for anti-A isoagglutinins using an automated indirect agglutination test ( IAT ) in gel cards was developed .", "sentence_id": 3}
+{"abstract_id": "26174905", "label": "methods", "text": "Industry-scale donor plasma pools and final IVIG product were prepared according to the manufacturing process of Privigen ( human @ % liquid IVIG ) .", "sentence_id": 4}
+{"abstract_id": "26174905", "label": "methods", "text": "Anti-A/B isoagglutinin levels were measured by IAT , direct agglutination test , and a flow cytometry-based assay .", "sentence_id": 5}
+{"abstract_id": "26174905", "label": "results", "text": "Screening of plasma from @ randomly selected donors identified @ % donors with high anti-A isoagglutinin titers in plasma .", "sentence_id": 6}
+{"abstract_id": "26174905", "label": "results", "text": "Exclusion of plasma from these donors resulted in a one-titer-step reduction of anti-A isoagglutinin in laboratory-scale pooled plasma .", "sentence_id": 7}
+{"abstract_id": "26174905", "label": "results", "text": "The same donor screening method applied to industry-scale production resulted in exclusion of @ % of donors and produced a one-titer-step reduction of both anti-A and anti-B isoagglutinin titers in the final IVIG product .", "sentence_id": 8}
+{"abstract_id": "26174905", "label": "conclusions", "text": "Anti-A/B isoagglutinin titers in IVIG products can be reduced on an industrial scale through implementation of anti-A donor screening , which may lower the risk of hemolysis after IVIG therapy .", "sentence_id": 9}
+{"abstract_id": "24853314", "label": "background", "text": "Rectus sheath block can provide analgesia following umbilical hernia repair .", "sentence_id": 0}
+{"abstract_id": "24853314", "label": "background", "text": "However , conflicting reports on its analgesic effectiveness exist .", "sentence_id": 1}
+{"abstract_id": "24853314", "label": "background", "text": "No study has investigated plasma local anesthetic concentration following ultrasound-guided rectus sheath block ( USGRSB ) in children .", "sentence_id": 2}
+{"abstract_id": "24853314", "label": "objective", "text": "Compare the effectiveness and bupivacaine absorption following USGRSB or wound infiltration ( WI ) for umbilical hernia repair in children .", "sentence_id": 3}
+{"abstract_id": "24853314", "label": "methods", "text": "A randomized blinded study comparing WI with USGRSB in @ children undergoing umbilical hernia repair was performed .", "sentence_id": 4}
+{"abstract_id": "24853314", "label": "methods", "text": "Group WI ( n = @ ) received wound infiltration @ mgkg ( -@ ) @ % bupivacaine .", "sentence_id": 5}
+{"abstract_id": "24853314", "label": "methods", "text": "Group RS ( n = @ ) received USGRSB @ mgkg ( -@ ) @ % bupivacaine per side in the posterior rectus sheath compartment .", "sentence_id": 6}
+{"abstract_id": "24853314", "label": "methods", "text": "Pain scores and rescue analgesia were recorded .", "sentence_id": 7}
+{"abstract_id": "24853314", "label": "methods", "text": "Blood samples were drawn at @ , @ , @ , @ , @ , and @ min .", "sentence_id": 8}
+{"abstract_id": "24853314", "label": "results", "text": "Patients in the WI group had a twofold increased risk of requiring morphine ( hazard ratio @ , @ % CI @ , @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24853314", "label": "results", "text": "When required , median time to first morphine dose was longer in the USGRSB group ( @ min vs. @ min , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24853314", "label": "results", "text": "Peak plasma bupivacaine concentration was higher following USGRSB than WI ( median : @ ngml ( -@ ) IQR : @-@ @ vs. @ ngml ( -@ ) IQR : @-@ @ , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24853314", "label": "results", "text": "Tmax was longer in the USGRSB group ( median @ min IQR : @-@ vs. @ min IQR : @-@ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24853314", "label": "conclusions", "text": "USGRSB provides more effective analgesia than WI for umbilical hernia repair .", "sentence_id": 13}
+{"abstract_id": "24853314", "label": "conclusions", "text": "USGRSB with @ mgkg ( -@ ) @ % bupivacaine is associated with safe plasma bupivacaine concentration that peaks higher and later than WI .", "sentence_id": 14}
+{"abstract_id": "24853314", "label": "conclusions", "text": "Caution against using larger volumes of higher concentration local anesthetic for USGRSB is advised .", "sentence_id": 15}
+{"abstract_id": "25345427", "label": "objective", "text": "Drug-drug interactions between canagliflozin , a sodium glucose co-transporter @ inhibitor approved for the management of type-@ diabetes mellitus , and an oral contraceptive ( OC ) , warfarin , and digoxin were evaluated in three phase @ studies in healthy participants .", "sentence_id": 0}
+{"abstract_id": "25345427", "label": "methods", "text": "All studies were open-label ; study @ included a fixed-sequence design , and studies @ and @ used a crossover design .", "sentence_id": 1}
+{"abstract_id": "25345427", "label": "methods", "text": "Regimens were : study @ : OC ( levonorgestrel ( @ g ) + ethinyl estradiol ( @ g ) ) / day ( day @ ) , canagliflozin @ mg/day ( days @ - @ ) , and canagliflozin with OC ( day @ ) ; study @ : canagliflozin @ mg/day ( days @ - @ ) with warfarin @ mg/day ( day @ ) in period @ , and only warfarin @ mg/day ( day @ ) in period @ , or vice versa ; study @ : digoxin alone ( @ mg/day ( day @ ) + @ mg/day ( days @ - @ ) ) in period @ , and with canagliflozin @ mg/day ( days @ - @ ) in period @ , or vice versa .", "sentence_id": 2}
+{"abstract_id": "25345427", "label": "methods", "text": "Pharmacokinetics ( PK ) were assessed at prespecified intervals ; OC : days @ and @ , canagliflozin : days @ - @ ( study @ ) ; warfarin : days @ ( period @ ) and @ ( period @ ) ( study @ ) ; and digoxin : days @ - @ ( periods @ and @ ) ( study @ ) .", "sentence_id": 3}
+{"abstract_id": "25345427", "label": "methods", "text": "Warfarin 's pharmacodynamics ( PD ; International Normalized Ratio ( INR ) ) was assessed on days @ ( period @ ) and @ ( period @ ) .", "sentence_id": 4}
+{"abstract_id": "25345427", "label": "results", "text": "Canagliflozin increased the plasma exposure of OC ( maximum plasma concentration ( Cmax ) : @ % , area under the curve ( AUC ) : @ % ) and digoxin ( Cmax : @ % , AUC : @ % ) ; but did not alter warfarin 's PK and PD .", "sentence_id": 5}
+{"abstract_id": "25345427", "label": "results", "text": "No clinically relevant safety findings ( including hypoglycemia ) were noted .", "sentence_id": 6}
+{"abstract_id": "25345427", "label": "conclusions", "text": "Canagliflozin can be coadministered with OC , warfarin , or digoxin without dose adjustments .", "sentence_id": 7}
+{"abstract_id": "25345427", "label": "conclusions", "text": "All treatments were well-tolerated .", "sentence_id": 8}
+{"abstract_id": "24270198", "label": "objective", "text": "This study aimed to determine during @ months of follow-up the ( @ ) clinical outcomes and ( @ ) influence of high-risk human papillomavirus ( HPV ) status on the risk of progression to cervical intraepithelial neoplasia @ + ( CIN @ + ) , among women with histologically proven CIN @ .", "sentence_id": 0}
+{"abstract_id": "24270198", "label": "methods", "text": "This is an ad hoc analysis of women with CIN @ within TOMBOLA , a randomized trial of the management of women with low-grade cervical cytology .", "sentence_id": 1}
+{"abstract_id": "24270198", "label": "methods", "text": "Women from the colposcopy arm with CIN @ confirmed on punch biopsies and managed conservatively by cytology every @ months in primary care were included .", "sentence_id": 2}
+{"abstract_id": "24270198", "label": "methods", "text": "Sociodemographic data and a sample for HPV testing were collected at recruitment .", "sentence_id": 3}
+{"abstract_id": "24270198", "label": "methods", "text": "Data on the sample women were extracted to calculate the cumulative incidence of CIN @ + and the performance characteristics of the baseline HPV test .", "sentence_id": 4}
+{"abstract_id": "24270198", "label": "methods", "text": "Detection of CIN @ or worse ( CIN @ + ) during follow-up or at exit colposcopy was analyzed .", "sentence_id": 5}
+{"abstract_id": "24270198", "label": "results", "text": "A total of @ women were included .", "sentence_id": 6}
+{"abstract_id": "24270198", "label": "results", "text": "Their median age was @ years .", "sentence_id": 7}
+{"abstract_id": "24270198", "label": "results", "text": "Fifty-two percent were high-risk HPV positive , @ % were HPV-@ positive , and @ % were HPV-@ positive .", "sentence_id": 8}
+{"abstract_id": "24270198", "label": "results", "text": "Overall , @ women ( @ % ) developed CIN @ + , with a median time to detection of @ months .", "sentence_id": 9}
+{"abstract_id": "24270198", "label": "results", "text": "Factors associated with progression to CIN @ + were presence of HPV-@ ( relative risk = @ ; @ % CI = @-@ @ ) and HPV-@ and/or HPV-@ at recruitment ( relative risk = @ ; @ % CI = @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24270198", "label": "results", "text": "The sensitivity and specificity of a combined HPV-@ / HPV-@ test for the detection of CIN @ + during @ years were @ % and @ % , respectively .", "sentence_id": 11}
+{"abstract_id": "24270198", "label": "conclusions", "text": "Our results suggest that women with confirmed CIN @ have low rates of progression to high-grade CIN within @ years .", "sentence_id": 12}
+{"abstract_id": "24270198", "label": "conclusions", "text": "Because the median time to progression was @ months , conservative management could recommend the next repeat cytology at @ years .", "sentence_id": 13}
+{"abstract_id": "24835757", "label": "objective", "text": "To determine longitudinal changes in angle configuration in the eyes of primary angle-closure suspects ( PACS ) treated by laser peripheral iridotomy ( LPI ) and in untreated fellow eyes .", "sentence_id": 0}
+{"abstract_id": "24835757", "label": "methods", "text": "Longitudinal cohort study .", "sentence_id": 1}
+{"abstract_id": "24835757", "label": "methods", "text": "Primary angle-closure suspects aged @ to @ years were enrolled in a randomized , controlled clinical trial .", "sentence_id": 2}
+{"abstract_id": "24835757", "label": "methods", "text": "Each participant was treated by LPI in @ randomly selected eye , with the fellow eye serving as a control .", "sentence_id": 3}
+{"abstract_id": "24835757", "label": "methods", "text": "Angle width was assessed in a masked fashion using gonioscopy and anterior segment optical coherence tomography ( AS-OCT ) before and at @ weeks , @ months , and @ months after LPI .", "sentence_id": 4}
+{"abstract_id": "24835757", "label": "methods", "text": "Angle width in degrees was calculated from Shaffer grades assessed under static gonioscopy .", "sentence_id": 5}
+{"abstract_id": "24835757", "label": "methods", "text": "Angle configuration was also evaluated using angle opening distance ( AOD@ , AOD@ , AOD@ ) , trabecular-iris space area ( TISA@ , TISA@ ) , and angle recess area ( ARA ) measured in AS-OCT images .", "sentence_id": 6}
+{"abstract_id": "24835757", "label": "results", "text": "No significant difference was found in baseline measures of angle configuration between treated and untreated eyes .", "sentence_id": 7}
+{"abstract_id": "24835757", "label": "results", "text": "At @ weeks after LPI , the drainage angle on gonioscopy widened from a mean of @ at baseline to a mean of @ in treated eyes , which was also confirmed by significant increases in all AS-OCT angle width measures ( P < @ for all variables ) .", "sentence_id": 8}
+{"abstract_id": "24835757", "label": "results", "text": "Between @ weeks and @ months after LPI , a significant decrease in angle width was observed over time in treated eyes ( P < @ for all variables ) , although the change over the first @ months was not statistically significant for angle width measured under gonioscopy ( P = @ ) , AOD@ ( P = @ ) and ARA ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24835757", "label": "results", "text": "In untreated eyes , angle width consistently decreased across all follow-up visits after LPI , with a more rapid longitudinal decrease compared with treated eyes ( P values for all variables @ ) .", "sentence_id": 10}
+{"abstract_id": "24835757", "label": "results", "text": "The annual rate of change in angle width was equivalent to @ / year ( @ % confidence interval -LSB- CI -RSB- , @-@ @ ) in treated eyes and @ / year ( @ % CI , @-@ @ ) in untreated eyes ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24835757", "label": "conclusions", "text": "Angle width of treated eyes increased markedly after LPI , remained stable for @ months , and then decreased significantly by @ months after LPI .", "sentence_id": 12}
+{"abstract_id": "24835757", "label": "conclusions", "text": "Untreated eyes experienced a more consistent and rapid decrease in angle width over the same time period .", "sentence_id": 13}
+{"abstract_id": "25541333", "label": "objective", "text": "Chronic pain and progressive loss of physical function with AS may adversely affect health-related quality of life ( HRQoL ) .", "sentence_id": 0}
+{"abstract_id": "25541333", "label": "objective", "text": "The objective of this study was to assess the @-year data regarding spinal mobility , physical function and HRQoL in patients with AS who participated in the Adalimumab Trial Evaluating Long-term Efficacy and Safety for AS ( ATLAS ) study .", "sentence_id": 1}
+{"abstract_id": "25541333", "label": "methods", "text": "Patients received blinded adalimumab @ mg or placebo every other week for @ weeks , then open-label adalimumab for up to @ years .", "sentence_id": 2}
+{"abstract_id": "25541333", "label": "methods", "text": "Spinal mobility was evaluated using linear BASMI ( BASMIlin ) .", "sentence_id": 3}
+{"abstract_id": "25541333", "label": "methods", "text": "BASDAI , total back pain , CRP , BASFI , Short Form-@ and AS quality of life ( ASQoL ) were also assessed .", "sentence_id": 4}
+{"abstract_id": "25541333", "label": "methods", "text": "Correlations between BASMIlin and clinical , functional and ASQoL outcomes after @ weeks and after @years of adalimumab exposure were evaluated using Spearman 's rank correlation .", "sentence_id": 5}
+{"abstract_id": "25541333", "label": "methods", "text": "Associations were further analysed using multivariate regression .", "sentence_id": 6}
+{"abstract_id": "25541333", "label": "results", "text": "Three hundred and eleven patients received @ dose of adalimumab ; @ of the @ patients originally randomized to adalimumab received treatment for @ years .", "sentence_id": 7}
+{"abstract_id": "25541333", "label": "results", "text": "Improvements in BASMIlin were sustained through @ years , with a mean change of -@ from baseline in the population who completed @ years of treatment with adalimumab .", "sentence_id": 8}
+{"abstract_id": "25541333", "label": "results", "text": "Improvements in disease activity , physical function and ASQoL were also sustained through @ years .", "sentence_id": 9}
+{"abstract_id": "25541333", "label": "results", "text": "BASMIlin was significantly correlated with all evaluated clinical outcomes ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25541333", "label": "results", "text": "The highest correlation was with BASFI at @ weeks ( r = @ ) and at @ years ( r = @ ) .", "sentence_id": 11}
+{"abstract_id": "25541333", "label": "results", "text": "Multivariate regression analysis confirmed this association ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25541333", "label": "conclusions", "text": "Treatment with adalimumab for up to @ years demonstrated sustained benefits in spinal mobility , disease activity , physical function and HRQoL in patients with active AS .", "sentence_id": 13}
+{"abstract_id": "25541333", "label": "conclusions", "text": "Spinal mobility was significantly associated with short - and long-term physical function in these patients .", "sentence_id": 14}
+{"abstract_id": "24680759", "label": "background", "text": "The intragastric balloon has been reported to be a safe and effective tool for temporary weight loss .", "sentence_id": 0}
+{"abstract_id": "24680759", "label": "background", "text": "The aim of this study is the evaluation of the possible predictive role of intragastric balloon when used before laparoscopic adjustable gastric banding .", "sentence_id": 1}
+{"abstract_id": "24680759", "label": "methods", "text": "A longitudinal multicenter study was conducted in patients with body mass index ( BMI ) > @ kg/m ( @ ) who underwent gastric banding with the BioEnterics Intragastric Balloon ( BIB ) .", "sentence_id": 2}
+{"abstract_id": "24680759", "label": "methods", "text": "After balloon removal ( @ mo ) , patients were allocated into @ group according to their percentage of excess weight loss ( % EWL ) : group > @ ( % EWL > @ % ) and group < @ ( % EWL < @ % ) .", "sentence_id": 3}
+{"abstract_id": "24680759", "label": "methods", "text": "Patients from both group underwent laparoscopic adjustable gastric banding ( LAGB ) @-@ months after BIB removal .", "sentence_id": 4}
+{"abstract_id": "24680759", "label": "methods", "text": "The LAP-BAND AP band was placed in all patients via pars flaccida .", "sentence_id": 5}
+{"abstract_id": "24680759", "label": "methods", "text": "Weight loss parameters were considered in both groups .", "sentence_id": 6}
+{"abstract_id": "24680759", "label": "results", "text": "From January @ to December @ , @ patients were enrolled in this study .", "sentence_id": 7}
+{"abstract_id": "24680759", "label": "results", "text": "Mean BMI at time of BIB positioning was @ ( range @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24680759", "label": "results", "text": "After @ months , at time of removal , mean BMI was @ .", "sentence_id": 9}
+{"abstract_id": "24680759", "label": "results", "text": "According to the cutoff , patients were allocated into group A ( n = @ ) and group B ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "24680759", "label": "results", "text": "At this time the mean BMI was @ and @ ( P = @ ) in groups A and B , respectively .", "sentence_id": 11}
+{"abstract_id": "24680759", "label": "results", "text": "At @-year follow-up from LAGB , mean BMI was @ and @ ( P < @ ) in groups A and B , respectively .", "sentence_id": 12}
+{"abstract_id": "24680759", "label": "results", "text": "This significant difference was confirmed at @ - and @-year follow-ups .", "sentence_id": 13}
+{"abstract_id": "24680759", "label": "results", "text": "A similar pattern was observed with the % EWL .", "sentence_id": 14}
+{"abstract_id": "24680759", "label": "conclusions", "text": "Satisfactory results with BIB are predictive of a positive outcome of LASB at @ , @ , and @ years after the procedure , and poor results do not inevitably indicate a negative outcome for gastric banding .", "sentence_id": 15}
+{"abstract_id": "25297013", "label": "background", "text": "Calcitonin gene-related peptide ( CGRP ) is crucial in the pathophysiology of migraine .", "sentence_id": 0}
+{"abstract_id": "25297013", "label": "background", "text": "We assessed the safety , tolerability , and efficacy of ALD@ , a genetically engineered humanised anti-CGRP antibody , for migraine prevention .", "sentence_id": 1}
+{"abstract_id": "25297013", "label": "methods", "text": "In this randomised , double-blind , placebo-controlled , exploratory , proof-of-concept phase @ trial , patients aged @-@ years with five to @ migraine days per @-day period were randomly assigned ( @:@ ) via an interactive web response system to receive an intravenous dose of ALD@ @ mg or placebo .", "sentence_id": 2}
+{"abstract_id": "25297013", "label": "methods", "text": "Site investigators , patients , and the sponsor were masked to treatment allocation during the study .", "sentence_id": 3}
+{"abstract_id": "25297013", "label": "methods", "text": "The primary objective was to assess safety at @ weeks after infusion .", "sentence_id": 4}
+{"abstract_id": "25297013", "label": "methods", "text": "The primary efficacy endpoint was the change from baseline to weeks @-@ in the frequency of migraine days , as recorded in patient electronic diaries .", "sentence_id": 5}
+{"abstract_id": "25297013", "label": "methods", "text": "Patients were followed up until @ weeks for exploratory safety and efficacy analyses .", "sentence_id": 6}
+{"abstract_id": "25297013", "label": "methods", "text": "Safety and efficacy analyses were done by intention to treat .", "sentence_id": 7}
+{"abstract_id": "25297013", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 8}
+{"abstract_id": "25297013", "label": "results", "text": "Between Jan @ , @ , and Dec @ , @ , of @ patients randomly assigned at @ centres in the USA , @ received either ALD@ ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 9}
+{"abstract_id": "25297013", "label": "results", "text": "Adverse events were experienced by @ ( @ % ) of @ patients in the ALD@ group and @ ( @ % ) of @ in the placebo group .", "sentence_id": 10}
+{"abstract_id": "25297013", "label": "results", "text": "The most frequent adverse events were upper respiratory tract infection ( placebo @ -LSB- @ % -RSB- patients vs ALD@ @ -LSB- @ % -RSB- patients ) , urinary tract infection ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , back pain ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , arthralgia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and nausea and vomiting ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "25297013", "label": "results", "text": "Six serious adverse events were reported by three patients and were judged to be unrelated to study drug : in the ALD@ group , one patient had four serious adverse events and one had one serious adverse event , and in the placebo group , one patient had one serious adverse event .", "sentence_id": 12}
+{"abstract_id": "25297013", "label": "results", "text": "There were no differences in vital signs or laboratory safety data between the two treatment groups .", "sentence_id": 13}
+{"abstract_id": "25297013", "label": "results", "text": "The mean change in migraine days between baseline and weeks @-@ was -@ ( SD @ ) for the ALD@ group compared with -@ ( @ ) for the placebo group ( difference -@ , @ % CI -@ to @ ; one-sided p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25297013", "label": "conclusions", "text": "No safety concerns were noted with an intravenous dose of ALD@ @ mg .", "sentence_id": 15}
+{"abstract_id": "25297013", "label": "conclusions", "text": "This study also provides preliminary evidence for the efficacy of ALD@ in the preventive treatment of migraine in patients with a high monthly frequency of migraine days .", "sentence_id": 16}
+{"abstract_id": "25111236", "label": "objective", "text": "Polycystic liver disease ( PLD ) , the most common extrarenal manifestation of autosomal-dominant polycystic kidney disease ( ADPKD ) , has become more prevalent as a result of increased life expectancy , improved renal survival , reduced cardiovascular mortality , and renal replacement therapy .", "sentence_id": 0}
+{"abstract_id": "25111236", "label": "objective", "text": "No studies have fully characterized PLD in large cohorts .", "sentence_id": 1}
+{"abstract_id": "25111236", "label": "objective", "text": "We investigated whether liver and cyst volumes are associated with volume of the hepatic parenchyma , results from liver laboratory tests , and patient-reported outcomes .", "sentence_id": 2}
+{"abstract_id": "25111236", "label": "methods", "text": "We performed a cross-sectional analysis of baseline liver volumes , measured by magnetic resonance imaging , and their association with demographics , results from liver laboratory and other tests , and quality of life .", "sentence_id": 3}
+{"abstract_id": "25111236", "label": "methods", "text": "The data were collected from a randomized , placebo-controlled trial underway at @ tertiary-care medical centers to determine whether the combination of an angiotensin I-converting enzyme inhibitor and angiotensin II-receptor blocker was superior to the inhibitor alone , and whether low blood pressure ( < @/@ mm Hg ) was superior to standard blood pressure ( @-@/@ -@ mm Hg ) , in delaying renal cystic progression in @ patients with ADPKD , stages @ and @ chronic kidney disease , and hypertension ( age , @-@ y ) .", "sentence_id": 4}
+{"abstract_id": "25111236", "label": "results", "text": "We found hepatomegaly to be common among patients with ADPKD .", "sentence_id": 5}
+{"abstract_id": "25111236", "label": "results", "text": "Cysts and parenchyma contributed to hepatomegaly .", "sentence_id": 6}
+{"abstract_id": "25111236", "label": "results", "text": "Cysts were more common and liver and cyst volumes were greater in women , increasing with age .", "sentence_id": 7}
+{"abstract_id": "25111236", "label": "results", "text": "Patients with advanced disease had a relative loss of liver parenchyma .", "sentence_id": 8}
+{"abstract_id": "25111236", "label": "results", "text": "We observed small abnormalities in results from liver laboratory tests , and that splenomegaly and hypersplenism were associated with PLD severity .", "sentence_id": 9}
+{"abstract_id": "25111236", "label": "results", "text": "Higher liver volumes were associated with a lower quality of life .", "sentence_id": 10}
+{"abstract_id": "25111236", "label": "conclusions", "text": "Hepatomegaly is common even in early stage ADPKD and is not accounted for by cysts alone .", "sentence_id": 11}
+{"abstract_id": "25111236", "label": "conclusions", "text": "Parenchymal volumes were larger , compared with liver volumes of patients without ADPKD or with those predicted by standardized equations , even among patients without cysts .", "sentence_id": 12}
+{"abstract_id": "25111236", "label": "conclusions", "text": "The severity of PLD was associated with altered biochemical and hematologic features , as well as quality of life .", "sentence_id": 13}
+{"abstract_id": "25111236", "label": "conclusions", "text": "ClinicalTrials.gov identifier : NCT@ .", "sentence_id": 14}
+{"abstract_id": "25412095", "label": "objective", "text": "Peripancreatic fluid collections ( PFCs ) have been adequately drained using multiple plastic stents placed in a single-step endoscopic ultrasound ( EUS ) procedure .", "sentence_id": 0}
+{"abstract_id": "25412095", "label": "objective", "text": "Recent reports have presented the usefulness of metal stents for this procedure ; however , there has been no prospective comparative study on their effectiveness and safety .", "sentence_id": 1}
+{"abstract_id": "25412095", "label": "objective", "text": "We conducted a prospective randomized study to compare multiple plastic stents with fully covered , self-expanding metal stents ( FCSEMSs ) for the drainage of PFCs .", "sentence_id": 2}
+{"abstract_id": "25412095", "label": "methods", "text": "Between January @ and May @ , patients with PFCs demonstrated by various modalities were enrolled in our study .", "sentence_id": 3}
+{"abstract_id": "25412095", "label": "methods", "text": "Patients were randomly assigned to receive either a FCSEMS or plastic stents for EUS-guided PFC drainage .", "sentence_id": 4}
+{"abstract_id": "25412095", "label": "methods", "text": "The procedure time , technical success rate , and adverse event rates of the PFCs were evaluated .", "sentence_id": 5}
+{"abstract_id": "25412095", "label": "results", "text": "@ patients ( @ men ) were included and randomly assigned to either the FCSEMS group ( n = @ ) or the plastic stent group ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "25412095", "label": "results", "text": "The median procedure time with FCSEMS was significantly shorter than with plastic stents ( @ min vs. @ min , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25412095", "label": "results", "text": "The technical success rate was @ % for both groups .", "sentence_id": 8}
+{"abstract_id": "25412095", "label": "results", "text": "The clinical success rate was @ out of @ for FCSEMS and @ out of @ for plastic stents ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25412095", "label": "results", "text": "No adverse events occurred in the FCSEMS group , while adverse events occurred in two patients in the plastic stent group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25412095", "label": "results", "text": "One recurrence was observed during follow-up in the FCSEMS group and none in the plastic stent group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25412095", "label": "conclusions", "text": "EUS-guided PFC drainage with FCSEMSs is comparable to such drainage with plastic stents in terms of technical feasibility , efficacy , and safety ; however , the use of FCSEMSs may also simplify and shorten the procedure .", "sentence_id": 12}
+{"abstract_id": "24517298", "label": "background", "text": "It is projected that in Australia there will be between @ % and @ % of palliative care patients living alone by the year @ .", "sentence_id": 0}
+{"abstract_id": "24517298", "label": "background", "text": "As such , it will become increasingly important to provide appropriate home-based care in order to support these patients to be cared for and die at home .", "sentence_id": 1}
+{"abstract_id": "24517298", "label": "objective", "text": "This study explored the experiences of community-based palliative care cancer patients who live alone without a caregiver and what psychosocial issues they face .", "sentence_id": 2}
+{"abstract_id": "24517298", "label": "methods", "text": "Face-to-face semistructured interviews were conducted with eight participants , and constant comparison was used for the analysis .", "sentence_id": 3}
+{"abstract_id": "24517298", "label": "results", "text": "Four main themes emerged : ( @ ) loss of social networks ; ( @ ) maintaining independence ; ( @ ) balancing independence and the need for assistance ; and ( @ ) planning for the end of life .", "sentence_id": 4}
+{"abstract_id": "24517298", "label": "conclusions", "text": "Participants balanced independence with the need to accept help in order to maintain independence .", "sentence_id": 5}
+{"abstract_id": "24517298", "label": "conclusions", "text": "Participants became more flexible about their preferred place of death .", "sentence_id": 6}
+{"abstract_id": "24517298", "label": "conclusions", "text": "The practice implications for working with people close to death who are living alone are that supports and assistance may be needed to maintain social networks and also a sense of independence .", "sentence_id": 7}
+{"abstract_id": "24886378", "label": "background", "text": "The timely publication of findings in peer-reviewed journals is a primary goal of clinical research .", "sentence_id": 0}
+{"abstract_id": "24886378", "label": "background", "text": "In clinical trials , the processes leading to publication can be complex from choice and prioritization of analytic topics through to journal submission and revisions .", "sentence_id": 1}
+{"abstract_id": "24886378", "label": "background", "text": "As little literature exists on the publication process for multicenter trials , we describe the development , implementation , and effectiveness of such a process in a multicenter trial .", "sentence_id": 2}
+{"abstract_id": "24886378", "label": "methods", "text": "The Hepatitis C Antiviral Long-Term Treatment against Cirrhosis ( HALT-C ) trial included a data coordinating center ( DCC ) and clinical centers that recruited and followed more than @,@ patients .", "sentence_id": 3}
+{"abstract_id": "24886378", "label": "methods", "text": "Publication guidelines were approved by the steering committee , and the publications committee monitored the publication process from selection of topics to publication .", "sentence_id": 4}
+{"abstract_id": "24886378", "label": "results", "text": "A total of @ manuscripts were published in @ peer-reviewed journals .", "sentence_id": 5}
+{"abstract_id": "24886378", "label": "results", "text": "When manuscripts were closely tracked , the median time for analyses and drafting of manuscripts was @months .", "sentence_id": 6}
+{"abstract_id": "24886378", "label": "results", "text": "The median time for data analyses was @months and the median time for manuscript drafting was @months .", "sentence_id": 7}
+{"abstract_id": "24886378", "label": "results", "text": "The median time for publications committee review , submission , and journal acceptance was @months , and the median time from analytic start to journal acceptance was @months .", "sentence_id": 8}
+{"abstract_id": "24886378", "label": "conclusions", "text": "Effective publication guidelines must be comprehensive , implemented early in a trial , and require active management by study investigators .", "sentence_id": 9}
+{"abstract_id": "24886378", "label": "conclusions", "text": "Successful collaboration , such as in the HALT-C trial , can serve as a model for others involved in multidisciplinary and multicenter research programs .", "sentence_id": 10}
+{"abstract_id": "24801269", "label": "background", "text": "Several evidences have supported the benefits of home blood pressure monitoring ( HBPM ) in improving hypertension awareness and control .", "sentence_id": 0}
+{"abstract_id": "24801269", "label": "background", "text": "However , little was known about the use of HBPM by hypertensive patients in primary care in China .", "sentence_id": 1}
+{"abstract_id": "24801269", "label": "methods", "text": "A cross-sectional questionnaire survey on HBPM use was conducted on @ hypertensive patients in Xinzhuang County Hospital in Shanghai , and the factors related to regular use of HBPM were also determined .", "sentence_id": 2}
+{"abstract_id": "24801269", "label": "results", "text": "Overall , @ of the @ participants engaged in using HBPM , among whom @ individuals used HBPM more than once a month .", "sentence_id": 3}
+{"abstract_id": "24801269", "label": "results", "text": "Of the @ HBPM users , @ % chose a mercury sphygmomanometer , @ % used wrist-cuff electronic devices , and @ % selected arm-cuff electronic devices .", "sentence_id": 4}
+{"abstract_id": "24801269", "label": "results", "text": "In addition , @ % of HBPM users reported HBP readings to their general practitioners .", "sentence_id": 5}
+{"abstract_id": "24801269", "label": "results", "text": "Compared with the less frequent users , patients who used HBPM daily were likely to report their blood pressure ( BP ) values to the doctors depending on notebook or mechanical memory than on their own memories ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24801269", "label": "results", "text": "Moreover , patients with college education were @ times more likely than those with middle school education or less to engage in frequent HBPM use ( odds ratio = @ , @ % confidence interval = @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24801269", "label": "conclusions", "text": "This local community survey showed that @ % of hypertension patients used HBPM frequently in primary care in China .", "sentence_id": 8}
+{"abstract_id": "24801269", "label": "conclusions", "text": "However , certain patients chose the improper BP monitoring device or questionable reporting methods .", "sentence_id": 9}
+{"abstract_id": "24801269", "label": "conclusions", "text": "Therefore , the use of arm-cuff electric devices with multiple memory storage or a home BP telemonitoring system should be promoted by health education targeted at hypertensive patients .", "sentence_id": 10}
+{"abstract_id": "24878589", "label": "background", "text": "Use of rehabilitation technology , such as ( electro ) mechanical devices or robotics , could partly relieve the increasing strain on stroke rehabilitation caused by an increasing prevalence of stroke .", "sentence_id": 0}
+{"abstract_id": "24878589", "label": "background", "text": "Arm support ( AS ) training showed improvement of unsupported arm function in chronic stroke .", "sentence_id": 1}
+{"abstract_id": "24878589", "label": "objective", "text": "To examine the effect of weight-supported arm training combined with computerized exercises on arm function and capacity , compared with dose-matched conventional reach training in subacute stroke patients .", "sentence_id": 2}
+{"abstract_id": "24878589", "label": "methods", "text": "In a single-blind , multicenter , randomized controlled trial , @ subacute stroke patients received @ weeks of training with either an AS device combined with computerized exercises or dose-matched conventional training ( CON ) .", "sentence_id": 3}
+{"abstract_id": "24878589", "label": "methods", "text": "Arm function was evaluated pretraining and posttraining by Fugl-Meyer assessment ( FM ) , maximal reach distance , Stroke Upper Limb Capacity Scale ( SULCS ) , and arm pain via Visual Analogue Scale , in addition to perceived motivation by Intrinsic Motivation Inventory posttraining .", "sentence_id": 4}
+{"abstract_id": "24878589", "label": "results", "text": "FM and SULCS scores and reach distance improved significantly within both groups .", "sentence_id": 5}
+{"abstract_id": "24878589", "label": "results", "text": "These improvements and experienced pain did not differ between groups .", "sentence_id": 6}
+{"abstract_id": "24878589", "label": "results", "text": "The AS group reported higher interest/enjoyment during training than the CON group .", "sentence_id": 7}
+{"abstract_id": "24878589", "label": "conclusions", "text": "AS training with computerized exercises is as effective as conventional therapy dedicated to the arm to improve arm function and activity in subacute stroke rehabilitation , when applied at the same dose .", "sentence_id": 8}
+{"abstract_id": "25310118", "label": "background", "text": "Rates of retention in care of HIV-positive pregnant women in care programs in Nigeria remain generally poor with rates around @ % reported for specific programs .", "sentence_id": 0}
+{"abstract_id": "25310118", "label": "background", "text": "Poor quality of services in health facilities and long waiting times are among the critical factors militating against retention of these women in care .", "sentence_id": 1}
+{"abstract_id": "25310118", "label": "background", "text": "The aim of the interventions in this study is to assess whether a continuous quality improvement intervention using a Breakthrough Series approach in local district hospitals and primary health care clinics will lead to improved retention of HIV-positive women and mothers .", "sentence_id": 2}
+{"abstract_id": "25310118", "label": "methods", "text": "A cluster randomized controlled trial with @ health facilities randomized to receive a continuous quality improvement/Breakthrough Series intervention or not .", "sentence_id": 3}
+{"abstract_id": "25310118", "label": "methods", "text": "The care protocol for HIV-infected pregnant women and mothers is the same in all sites .", "sentence_id": 4}
+{"abstract_id": "25310118", "label": "methods", "text": "The quality improvement intervention started @ months before enrollment of individual HIV-infected pregnant women and initially focused on reducing waiting times for women and also ensuring that antiretroviral drugs are dispensed on the same day as clinic attendance .", "sentence_id": 5}
+{"abstract_id": "25310118", "label": "methods", "text": "The primary outcome measure is retention of HIV-positive mothers in care at @ months postpartum .", "sentence_id": 6}
+{"abstract_id": "25310118", "label": "conclusions", "text": "Results of this trial will inform whether quality improvement interventions are an effective means of improving retention in prevention of mother-to-child transmission of HIV programs and will also guide where health system interventions should focus to improve the quality of care for HIV-positive women .", "sentence_id": 7}
+{"abstract_id": "25310118", "label": "conclusions", "text": "This will benefit policymakers and program managers as they seek to improve retention rates in HIV care programs .", "sentence_id": 8}
+{"abstract_id": "24853809", "label": "objective", "text": "Determine prevalence of diabetes , and describe use of blood glucose lowering ( BGL ) drugs and glycemic control in Norwegian nursing homes .", "sentence_id": 0}
+{"abstract_id": "24853809", "label": "methods", "text": "In this cross-sectional study we collected details of BGL drugs , capillary blood glucose measurements ( CBGM ) in the last four weeks and HbA@c measurements in the last @ months from the medical records of patients with diabetes , within a population of @ long-term care patients from @ randomly selected nursing homes in Western Norway .", "sentence_id": 1}
+{"abstract_id": "24853809", "label": "methods", "text": "Descriptive statistics were applied , and Pearson 's chi-squared ( P@ @ ) or non-overlapping @ % confidence intervals were interpreted as significant effects .", "sentence_id": 2}
+{"abstract_id": "24853809", "label": "results", "text": "@ patients ( @ % ) had diabetes , @ of these gave informed consent and medical data were available .", "sentence_id": 3}
+{"abstract_id": "24853809", "label": "results", "text": "BGL treatment was as follows : ( @ ) insulin only ( @ % ) , ( @ ) insulin and oral antidiabetics ( OADs ) ( @ % ) , ( @ ) OADs only ( @ % ) and ( @ ) no drugs ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "24853809", "label": "results", "text": "Patients with cognitive impairment were less likely to receive medical treatment ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24853809", "label": "results", "text": "CBGM and HbA@c measurements were performed for @ % and @ % of patients , respectively .", "sentence_id": 6}
+{"abstract_id": "24853809", "label": "results", "text": "Mean HbA@c was @ % ( @ mmol/mol ) , @ % of patients had an HbA@c < @ % ( @ mmol/mol ) , and CBGM consistent with risk of hypoglycemia was found for @ % of these patients .", "sentence_id": 7}
+{"abstract_id": "24853809", "label": "conclusions", "text": "Prevalence of diabetes and BGL treatment in Norwegian nursing homes is comparable to other European countries .", "sentence_id": 8}
+{"abstract_id": "24853809", "label": "conclusions", "text": "Although special care seems to be taken when choosing treatment for patients with cognitive impairment , there are signs of overtreatment in the population as a whole .", "sentence_id": 9}
+{"abstract_id": "24853809", "label": "conclusions", "text": "The strict glycemic control unveiled may negatively affect these frail patients ' quality of life and increase the risk of early death .", "sentence_id": 10}
+{"abstract_id": "24596360", "label": "objective", "text": "To investigate whether the negative quality of life result of a large randomized exercise intervention study ( BREX ) was due to considerable spontaneous recovery after adjuvant treatments .", "sentence_id": 0}
+{"abstract_id": "24596360", "label": "methods", "text": "The change in QoL was studied in the control patients of the BREX study ( Group @ ) and a group of similar follow-up patients that did not participate in any intervention study ( Group @ ) .", "sentence_id": 1}
+{"abstract_id": "24596360", "label": "methods", "text": "QoL was measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C@ with the breast cancer module supplement @ and @ months after surgery .", "sentence_id": 2}
+{"abstract_id": "24596360", "label": "results", "text": "QoL improved in both groups between @ and @ months after surgery .", "sentence_id": 3}
+{"abstract_id": "24596360", "label": "results", "text": "The improvement was similar in both groups for global QoL and for most of the QoL sub-scales .", "sentence_id": 4}
+{"abstract_id": "24596360", "label": "conclusions", "text": "No evidence was found to support the hypothesis that participation in an exercise intervention per se significantly improves QoL .", "sentence_id": 5}
+{"abstract_id": "24596360", "label": "conclusions", "text": "Spontaneous improvement in QoL began during the first six months after the primary treatments , which might have confounded the results of the intervention of the BREX study .", "sentence_id": 6}
+{"abstract_id": "24265330", "label": "objective", "text": "Cranial electrotherapy stimulation ( CES ) is used as a treatment for depression and anxiety , and as an adjunctive intervention for pain management .", "sentence_id": 0}
+{"abstract_id": "24265330", "label": "objective", "text": "This prospective study investigated whether CES could decrease preoperative anxiety , the injection pain of rocuronium , postoperative pain and stress hormone levels .", "sentence_id": 1}
+{"abstract_id": "24265330", "label": "methods", "text": "Female patients undergoing thyroidectomy were randomly assigned to two groups , to receive either no pretreatment ( control group ) or CES pretreatment .", "sentence_id": 2}
+{"abstract_id": "24265330", "label": "methods", "text": "Anxiety score , withdrawal response on rocuronium injection , and pain scores at @ , @ , @ and @ h post surgery were evaluated .", "sentence_id": 3}
+{"abstract_id": "24265330", "label": "methods", "text": "Adrenocorticotrophic hormone ( ACTH ) , cortisol and glucose levels were measured .", "sentence_id": 4}
+{"abstract_id": "24265330", "label": "methods", "text": "Patients were blinded to the treatment condition .", "sentence_id": 5}
+{"abstract_id": "24265330", "label": "results", "text": "Fifty patients entered the study ( n = @ per group ) .", "sentence_id": 6}
+{"abstract_id": "24265330", "label": "results", "text": "Anxiety score and withdrawal responses during rocuronium injection were significantly reduced in the CES group compared with the control group .", "sentence_id": 7}
+{"abstract_id": "24265330", "label": "results", "text": "Pain score was significantly lower in the CES group than in the control group , @ h and @ h post surgery .", "sentence_id": 8}
+{"abstract_id": "24265330", "label": "results", "text": "There were no significant differences in ACTH , cortisol and glucose levels .", "sentence_id": 9}
+{"abstract_id": "24265330", "label": "conclusions", "text": "CES pretreatment appears to reduce the level of preoperative anxiety , injection pain of rocuronium and postoperative pain .", "sentence_id": 10}
+{"abstract_id": "24265330", "label": "conclusions", "text": "However , CES pretreatment did not affect stress hormone responses .", "sentence_id": 11}
+{"abstract_id": "24702577", "label": "objective", "text": "To compare visual outcomes following photorefractive keratectomy ( PRK ) , PRK with mitomycin C ( MMC-PRK ) , and LASEK in moderate and high myopia in military personnel .", "sentence_id": 0}
+{"abstract_id": "24702577", "label": "methods", "text": "This prospective , randomized contralateral eye study included @ patients @ years or older with manifest spherical equivalent -@ @ diopters ( D ) ( range : -@ to -@ D ) randomized to either MMC-PRK or LASEK treatment in their dominant eye and conventional PRK without MMC in the fellow eye .", "sentence_id": 1}
+{"abstract_id": "24702577", "label": "methods", "text": "All procedures were performed using the LADARVision @ Excimer Laser System ( Alcon Surgical Inc. , Ft. Worth , TX ) .", "sentence_id": 2}
+{"abstract_id": "24702577", "label": "methods", "text": "High - and low-contrast visual acuities , manifest refraction , endothelial cell count , and corneal haze were evaluated up to @ months postoperatively .", "sentence_id": 3}
+{"abstract_id": "24702577", "label": "results", "text": "At @ months postoperatively , visual outcomes were comparable among the treatment groups .", "sentence_id": 4}
+{"abstract_id": "24702577", "label": "results", "text": "Corneal haze of any grade was less common in MMC-PRK compared to PRK at @ month ( @ % vs @ % ; P < @ ) and @ months ( @ % vs @ % ; P = @ ) postoperatively ; it was also less common in MMC-PRK compared to LASEK at @ month ( @ % vs @ % ; P < @ ) , @ months ( @ % vs @ % ; P < @ ) , and @ months ( @ % vs @ % ; P = @ ) postoperatively .", "sentence_id": 5}
+{"abstract_id": "24702577", "label": "results", "text": "Haze rate ( grade @ or higher ) was comparable between LASEK and PRK .", "sentence_id": 6}
+{"abstract_id": "24702577", "label": "results", "text": "Clinically significant haze ( grade @ or higher ) developed after PRK ( @ eyes ) and LASEK ( @ eyes ) , but not after MMC-PRK .", "sentence_id": 7}
+{"abstract_id": "24702577", "label": "conclusions", "text": "MMC-PRK showed some benefits in minimizing corneal haze formation .", "sentence_id": 8}
+{"abstract_id": "24702577", "label": "conclusions", "text": "One year after surgery , there was no discernible difference in the postoperative refractive outcomes among the three methods .", "sentence_id": 9}
+{"abstract_id": "25669614", "label": "objective", "text": "To establish the relative bioavailability ( rBA ) between two p.o. @-mg levomethadone hydrochloride formulations , i.e. , L-Polamidon @ mg tablets ( test ) vs. L-Polamidon solution for substitution ( reference ) .", "sentence_id": 0}
+{"abstract_id": "25669614", "label": "objective", "text": "To assess the safety and tolerability of both formulations .", "sentence_id": 1}
+{"abstract_id": "25669614", "label": "methods", "text": "A total of @ healthy male subjects , aged @ @ years ( BMI : @ @ kg/m@ ) completed this single center , open-label , randomized , @-period cross-over study with single dose administrations under fasting conditions and coadministration with naltrexone for safety reasons .", "sentence_id": 2}
+{"abstract_id": "25669614", "label": "methods", "text": "Administrations of both investigational products were separated by a washout period of at least @ weeks , i.e. , @ treatmentfree days .", "sentence_id": 3}
+{"abstract_id": "25669614", "label": "methods", "text": "The total dose for each subject was @ x @ mg resulting in @ mg levomethadone hydrochloride .", "sentence_id": 4}
+{"abstract_id": "25669614", "label": "methods", "text": "For pharmacokinetic evaluation , blood samples were withdrawn until @ hours postdose .", "sentence_id": 5}
+{"abstract_id": "25669614", "label": "methods", "text": "A validated non-stereoselective liquid chromatography-tandem mass spectroscopy method ( LC-MS/MS ) was applied for the determination of levomethadone in plasma .", "sentence_id": 6}
+{"abstract_id": "25669614", "label": "methods", "text": "The lower limit of quantitation was @ ng/mL .", "sentence_id": 7}
+{"abstract_id": "25669614", "label": "methods", "text": "Adverse events were descriptively analyzed in the study population .", "sentence_id": 8}
+{"abstract_id": "25669614", "label": "results", "text": "The geometric means of the parameters related with the extent of total exposure of levomethadone , i.e. , AUC ( @-tlast ) and AUC ( @ - ) , were @ ng x h/mL and @ ng x h/mL for test and @ ng x h/mL and @ ngh/mL for reference , respectively .", "sentence_id": 9}
+{"abstract_id": "25669614", "label": "results", "text": "The geometric means of the peak exposure for levomethadone , i.e. , Cmax , were @ ng/mL for test and @ ng/mL for reference .", "sentence_id": 10}
+{"abstract_id": "25669614", "label": "results", "text": "The point estimates ( PEs ) of the Test/Reference ( T/R ) adjusted geometric mean ratios of AUC ( @-last ) , AUC ( @ - ) , and C ( max ) were @ % , @ % , and @ % , respectively , and all of them showed @ % - confidence intervals ( CIs ) within the range of @ - @ % as suggested by regulatory requirements for bioequivalence assessment In total , @ subjects experienced @ AEs during the study , the most frequently reported AE , i.e. , headache , accounted for @ out of the total @ AEs ( @ % ) and no AEs of severe intensity were reported .", "sentence_id": 11}
+{"abstract_id": "25669614", "label": "conclusions", "text": "Bioequivalence could be demonstrated in terms of rate and extent of absorption after administration of test and reference products under naltrexone protection .", "sentence_id": 12}
+{"abstract_id": "25669614", "label": "conclusions", "text": "Concerning the safety evaluation , no negative implications on the possible use of the test formulation could be determined .", "sentence_id": 13}
+{"abstract_id": "25545757", "label": "background", "text": "Vincristine causes known side effects of peripheral sensory , motor , autonomic and cranial neuropathies .", "sentence_id": 0}
+{"abstract_id": "25545757", "label": "background", "text": "No preventive interventions are known .", "sentence_id": 1}
+{"abstract_id": "25545757", "label": "methods", "text": "We performed a randomized , placebo-controlled , double-blind trial of oral glutamic acid as a preventive agent in pediatric patients with cancer who would be receiving vincristine therapy for at least @ consecutive weeks ( Stratum @ = Wilms tumor and rhabdomyosarcoma ) or @ consecutive weeks in conjunction with steroids ( Stratum @ = Acute lymphoblastic leukemia and non-Hodgkin lymphoma ) .", "sentence_id": 2}
+{"abstract_id": "25545757", "label": "methods", "text": "At designated time points , a scored neurologic exam using the Modified Balis Pediatric Scale of Peripheral Neuropathies was performed to document neurologic toxicity .", "sentence_id": 3}
+{"abstract_id": "25545757", "label": "results", "text": "Between @ and @ , @ patients were enrolled ( Stratum @ = @ , Stratum @ = @ ) .", "sentence_id": 4}
+{"abstract_id": "25545757", "label": "results", "text": "The glutamic acid treated group did not have a significantly lower percentage of neurotoxicity compared to placebo treated group either overall or within stratum or age subgroups .", "sentence_id": 5}
+{"abstract_id": "25545757", "label": "results", "text": "The only subgroup which was suggestive of treatment effect was for age .", "sentence_id": 6}
+{"abstract_id": "25545757", "label": "results", "text": "Patients @ years or older showed a larger benefit in favor of glutamic acid ( P = @ ) compared to patients less than @ years ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25545757", "label": "results", "text": "Constipation was the most frequently reported ( @ % ) Grade II or higher neurotoxicity .", "sentence_id": 8}
+{"abstract_id": "25545757", "label": "conclusions", "text": "Vincristine-associated neurotoxicity in pediatric oncology remains a frequent complication of chemotherapy for multiple diagnoses with an approximate @ % of patients affected .", "sentence_id": 9}
+{"abstract_id": "25545757", "label": "conclusions", "text": "Glutamic acid is not effective for prevention in pre-adolescents .", "sentence_id": 10}
+{"abstract_id": "25545757", "label": "conclusions", "text": "There is a suggestion of benefit in patients @ years or older , but the study was not designed to provide adequate power to test the treatment effect within this age group alone .", "sentence_id": 11}
+{"abstract_id": "25621943", "label": "objective", "text": "To evaluate retinal sensitivity in patients with diabetic macular edema who received intravitreal aflibercept injection ( IAI ) or laser .", "sentence_id": 0}
+{"abstract_id": "25621943", "label": "methods", "text": "A substudy included @ patients from DA VINCI ( a randomized , double-masked Phase @ study ) receiving either laser , @ mg IAI every @ weeks , @ mg IAI every @ weeks , @ mg IAI every @ weeks after @ monthly doses ( @q@ ) , or @ mg IAI as-needed after @ monthly doses for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25621943", "label": "methods", "text": "Retinal sensitivity was measured in one ( central ) , five ( one central and four inner ) , and eight ( four inner and four outer ) optical coherence tomography subfields .", "sentence_id": 2}
+{"abstract_id": "25621943", "label": "results", "text": "Mean best-corrected visual acuity improvement in the subgroup at Week @ was @ letters with laser and ranged from @ to @ letters in the IAI groups .", "sentence_id": 3}
+{"abstract_id": "25621943", "label": "results", "text": "Retinal sensitivity of laser patients at Week @ was comparable with baseline in the central optical coherence tomography subfield but decreased in the five and eight optical coherence tomography subfields .", "sentence_id": 4}
+{"abstract_id": "25621943", "label": "results", "text": "Compared with laser , retinal sensitivity significantly increased with IAI in the @q@ and pooled IAI groups in the @ and @ optical coherence tomography subfields at Week @ ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25621943", "label": "conclusions", "text": "Intravitreal aflibercept injection improved best-corrected visual acuity and retinal sensitivity in this subgroup of patients .", "sentence_id": 6}
+{"abstract_id": "25621943", "label": "conclusions", "text": "Laser may cause a deterioration of macular function that is not detectable with best-corrected visual acuity testing .", "sentence_id": 7}
+{"abstract_id": "24812287", "label": "objective", "text": "Prediction of radiographic progression ( RP ) in early rheumatoid arthritis ( eRA ) would be very useful for optimal choice among available therapies .", "sentence_id": 0}
+{"abstract_id": "24812287", "label": "objective", "text": "We evaluated a multi-biomarker disease activity ( MBDA ) score , based on @ serum biomarkers as a baseline predictor for @-year RP in eRA .", "sentence_id": 1}
+{"abstract_id": "24812287", "label": "methods", "text": "Baseline disease activity score based on erythrocyte sedimentation rate ( DAS@-ESR ) , disease activity score based on C-reactive protein ( DAS@-CRP ) , CRP , MBDA scores and DAS@-ESR at @months were analysed for @ patients with eRA from the Swedish Farmacotherapy ( SWEFOT ) clinical trial .", "sentence_id": 2}
+{"abstract_id": "24812287", "label": "methods", "text": "RP was defined as an increase in the Van der Heijde-modified Sharp score by more than five points over @year .", "sentence_id": 3}
+{"abstract_id": "24812287", "label": "methods", "text": "Associations between baseline disease activity measures , the MBDA score , and @-year RP were evaluated using univariate and multivariate logistic regression , adjusted for potential confounders .", "sentence_id": 4}
+{"abstract_id": "24812287", "label": "results", "text": "Among @ patients with eRA , @ had low and @ moderate MBDA scores at baseline .", "sentence_id": 5}
+{"abstract_id": "24812287", "label": "results", "text": "None of the former and only one of the latter group ( @ % ) had RP during @year , while the proportion of patients with RP among those with high MBDA score was @ % ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24812287", "label": "results", "text": "Among patients with low/moderate CRP , moderate DAS@-CRP or moderate DAS@-ESR at baseline , progression occurred in @ % , @ % , @ % and @ % , respectively .", "sentence_id": 7}
+{"abstract_id": "24812287", "label": "results", "text": "MBDA score was an independent predictor of RP as a continuous ( OR = @ , @ % CI @ to @ ) and dichotomised variable ( high versus low/moderate , OR = @ , @ % CI @ to @ ) .", "sentence_id": 8}
+{"abstract_id": "24812287", "label": "conclusions", "text": "In patients with eRA , the MBDA score at baseline was a strong independent predictor of @-year RP .", "sentence_id": 9}
+{"abstract_id": "24812287", "label": "conclusions", "text": "These results suggest that when choosing initial treatment in eRA the MBDA test may be clinically useful to identify a subgroup of patients at low risk of RP .", "sentence_id": 10}
+{"abstract_id": "24622318", "label": "background", "text": "Results of an exploratory phase @ study showed that insulin degludec , a basal insulin with an action profile of longer than @ h , provided similar glycaemic control when injected three times a week ( IDeg @TW ) to once-daily insulin glargine ( IGlar OD ) .", "sentence_id": 0}
+{"abstract_id": "24622318", "label": "background", "text": "To provide further evidence , we did two phase @ trials to compare the efficacy and safety of IDeg @TW with IGlar OD in insulin-naive patients with type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "24622318", "label": "methods", "text": "In two @ week , randomised , open-label , parallel group , non-inferiority trials IDeg was injected Monday , Wednesday , and Friday before breakfast ( IDeg @TW ( AM ) ) in the AM trial ( @ sites in seven countries ) or with the evening meal ( IDeg @TW ( PM ) ) in the PM trial ( @ sites in seven countries ) , and compared with IGlar OD .", "sentence_id": 2}
+{"abstract_id": "24622318", "label": "methods", "text": "Adults with type @ diabetes ( HbA ( @c ) @-@ @ % ; body-mass index @ kg/m ( @ ) ) were randomly allocated ( @:@ ) without stratification by a central interactive response system to IDeg @TW or IGlar OD .", "sentence_id": 3}
+{"abstract_id": "24622318", "label": "methods", "text": "Both groups continued taking metformin with or without dipeptidyl peptidase-@ inhibitors .", "sentence_id": 4}
+{"abstract_id": "24622318", "label": "methods", "text": "Insulin was titrated to achieve a prebreakfast self-monitored blood glucose ( SMBG ) concentration of between @ and less than @ mmol/L .", "sentence_id": 5}
+{"abstract_id": "24622318", "label": "methods", "text": "The primary outcome was non-inferiority of IDeg @TW compared with IGlar OD , as assessed by change in HbA ( @c ) from baseline to @ weeks ( non-inferiority limit of @ % ) by ANOVA in an intent-to-treat analysis ( full analysis set ) .", "sentence_id": 6}
+{"abstract_id": "24622318", "label": "methods", "text": "These trials are registered with ClinicalTrials.gov , numbers NCT@ and NCT@ .", "sentence_id": 7}
+{"abstract_id": "24622318", "label": "results", "text": "We recruited @ patients for the AM trial ( IDeg @TW ( AM ) , n = @ ; IGlar OD , n = @ ) and @ patients for the PM trial ( IDeg @TW ( PM ) , n = @ ; IGlar OD , n = @ ) .", "sentence_id": 8}
+{"abstract_id": "24622318", "label": "results", "text": "After @ weeks , mean HbA decreased by @ % ( IDeg @TW ( AM ) ) and @ % ( IGlar OD ) in the AM trial , and by @ % ( IDeg @TW ( PM ) ) and @ % ( IGlar OD ) in the PM trial .", "sentence_id": 9}
+{"abstract_id": "24622318", "label": "results", "text": "Non-inferiority was not confirmed in either trial ( estimated treatment difference -LSB- IDeg @TW ( AM ) - IGlar OD -RSB- @ % , @ % CI @-@ @ ; -LSB- IDeg @TW ( PM ) - IGlar OD -RSB- @ % , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24622318", "label": "results", "text": "Across the two trials , rates of confirmed hypoglycaemia ( SMBG < @ mmol/L or severe -LSB- needing assistance -RSB- ) ranged from @ to @ episodes per patient-year and were similar for IDeg @TW ( AM ) and IGlar OD ( estimated rate ratio -LSB- ERR -RSB- @ , @ % CI @-@ @ ) , but higher for IDeg @TW ( PM ) than for IGlar OD ( ERR @ , @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24622318", "label": "results", "text": "The rate of nocturnal confirmed hypoglycaemia was higher for IDeg @TW ( AM ) than for IGlar OD ( ERR @ , @-@ @ ) ; we noted no significant difference between IDeg @TW ( PM ) and IGlar OD ( ERR @ , @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "24622318", "label": "conclusions", "text": "The inferior glycaemic control and increased risk of hypoglycaemia with IDeg @TW compared with IGlar OD do not support a three-times-weekly dosing regimen .", "sentence_id": 13}
+{"abstract_id": "24623027", "label": "objective", "text": "To evaluate the efficacy of two office-based treatments designed to prevent deterioration in glycemic control in young adolescents with type @ diabetes in a randomized clinical trial .", "sentence_id": 0}
+{"abstract_id": "24623027", "label": "objective", "text": "An individualized , more intensive family teamwork Coping skills program was compared with a diabetes Education treatment .", "sentence_id": 1}
+{"abstract_id": "24623027", "label": "methods", "text": "A baseline assessment was followed by four brief treatment sessions and immediate posttesting over the course of @ years .", "sentence_id": 2}
+{"abstract_id": "24623027", "label": "methods", "text": "Families of @ early adolescents ( ages @-@ ) were randomized to receive either individualized coping skills education or diabetes education as adjunctive treatment to quarterly medical appointments .", "sentence_id": 3}
+{"abstract_id": "24623027", "label": "methods", "text": "Continued follow-up occurred at @-month intervals for a long-term follow-up of up to @ years .", "sentence_id": 4}
+{"abstract_id": "24623027", "label": "methods", "text": "A post hoc Usual Care group facilitated comparisons of glycemic control .", "sentence_id": 5}
+{"abstract_id": "24623027", "label": "results", "text": "Growth curve analysis showed that both treatment groups successfully prevented deterioration in adolescent disease care and simultaneously improved adolescent and parent quality of life that included indicators of more effective communication and reduced adherence barriers-without a concomitant increase in diabetes-related or general family conflict .", "sentence_id": 6}
+{"abstract_id": "24623027", "label": "results", "text": "However , contrary to expectation , the Education group was more efficacious than the Coping group in improvement of disease adherence and glycemic control over a @-year follow-up .", "sentence_id": 7}
+{"abstract_id": "24623027", "label": "conclusions", "text": "Low-intensity office-based quarterly treatment can maintain or improve disease care adherence in early adolescence when provided to adolescent/parent dyads .", "sentence_id": 8}
+{"abstract_id": "24623027", "label": "conclusions", "text": "Better outcomes are achieved when treatment goals and techniques match the needs of the targeted population .", "sentence_id": 9}
+{"abstract_id": "24338466", "label": "background", "text": "In spinal anaesthesia for a Caesarean delivery , it is important to limit anaesthesia only at the surgical area , and to resolve fast motor block .", "sentence_id": 0}
+{"abstract_id": "24338466", "label": "background", "text": "We compared the intraoperative effectiveness , hemodynamic effects , anaesthetic recovery times and patients satisfaction after isobaric levobupivacaine ( L ) @ % versus L@ @ % spinal anaesthesia during elective Caesarean deliveries performed with the Stark technique .", "sentence_id": 1}
+{"abstract_id": "24338466", "label": "methods", "text": "In this double-blinded prospective study , seventy women undergoing elective caesarean delivery were randomized to receive either intrathecal @ mg Levobupivacaine @ % plus sufentanil @ g ( Group L@ @ ) , or intrathecal @ mg L @ % plus sufentanil @ g ( GroupControl ) .", "sentence_id": 2}
+{"abstract_id": "24338466", "label": "methods", "text": "The onset time , duration of anaesthesia , analgesia and sensory and motor block and hemodynamic parameters were measured from the beginning of spinal anaesthesia until four hours after spinal anaesthesia ( T@ ) .", "sentence_id": 3}
+{"abstract_id": "24338466", "label": "results", "text": "Onset time , duration of anaesthesia and haemodynamic variations were similar in the two groups .", "sentence_id": 4}
+{"abstract_id": "24338466", "label": "results", "text": "No patients required general anesthesia to complete surgery .", "sentence_id": 5}
+{"abstract_id": "24338466", "label": "results", "text": "Motor block vanished faster in Group L@ @ as compared with GroupControl ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24338466", "label": "results", "text": "The cephalad spread of the @ % solution was higher than that of the @ % solution : no patient in Group L@ @ experienced paresthesia of the upper limbs vs @ % in GroupControl ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24338466", "label": "results", "text": "In GroupControl anaesthesia reached the dermatome T@ in @ % of cases .", "sentence_id": 8}
+{"abstract_id": "24338466", "label": "results", "text": "Maternal and surgeon satisfaction was good in every patient .", "sentence_id": 9}
+{"abstract_id": "24338466", "label": "conclusions", "text": "Levobupivacaine @ milligrams at @ % may be used as a suitable alternative to L @ % for spinal anaesthesia for caesarean deliveris with the Stark technique with good maternal satisfaction .", "sentence_id": 10}
+{"abstract_id": "24338466", "label": "conclusions", "text": "In Group L@ @ a lower appearance of nausea and hypotension were observed and motor and sensitive block developed and diminished faster while no clinically significant differences in hemodynamic behavior was observed between groups .", "sentence_id": 11}
+{"abstract_id": "24864325", "label": "objective", "text": "To compare functional and morphological outcomes of femtosecond laser clear corneal incision ( CCI ) versus manual CCI during cataract surgery .", "sentence_id": 0}
+{"abstract_id": "24864325", "label": "methods", "text": "Sixty eyes of @ patients who underwent CCI during cataract surgery were randomized into two groups : femtosecond laser CCI ( @ eyes ) and manual CCI ( @ eyes ) .", "sentence_id": 1}
+{"abstract_id": "24864325", "label": "results", "text": "There were no significant between-group differences in uncorrected distance visual acuity , corrected distance visual acuity , surgically induced astigmatism , and corneal aberrations .", "sentence_id": 2}
+{"abstract_id": "24864325", "label": "results", "text": "Keratometric astigmatism was significantly lower in the femtosecond laser CCI group compared to the manual CCI group at @ and @ days ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24864325", "label": "results", "text": "Central endothelial cell count was significantly higher in the femtosecond laser CCI group compared to the manual CCI group at @ and @ days postoperatively ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24864325", "label": "results", "text": "A lower increase of corneal thickness at the incision site was observed at @ and @ days postoperatively in the femtosecond laser CCI group compared to the manual CCI group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24864325", "label": "results", "text": "In addition , femtosecond laser CCI showed a better morphology ( lower percentage of endothelial and epithelial gaping and endothelial misalignment ) compared to manual CCI at different time points .", "sentence_id": 6}
+{"abstract_id": "24864325", "label": "results", "text": "Total phacoemulsification time was significantly lower in the femtosecond laser CCI group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24864325", "label": "conclusions", "text": "The femtosecond laser procedure was safe , efficient , and less damaging , as evidenced by lower central endothelial cell loss , lower increase of corneal thickness at the incision site , and better tunnel morphology compared to the manual technique .", "sentence_id": 8}
+{"abstract_id": "24887252", "label": "objective", "text": "The aim of this study was to compare the duration of postoperative analgesia and possible adverse effects produced by caudal bupivacaine @ % at @ ml/kg with or without @ ug/kg of neostigmine in children undergoing unilateral herniotomy .", "sentence_id": 0}
+{"abstract_id": "24887252", "label": "methods", "text": "Sixty-six children aged @-@ years , of ASA physical status classes I or II for elective unilateral herniotomy under general anaesthesia without premedication were studied .", "sentence_id": 1}
+{"abstract_id": "24887252", "label": "methods", "text": "The patients were randomly allocated into two groups of @ each .", "sentence_id": 2}
+{"abstract_id": "24887252", "label": "methods", "text": "Group B received caudal analgesia with plain bupivacaine @ % at @ ml/kg alone , while group BN received caudal analgesia using a mixture of plain bupivacaine @ % at @ ml/kg and neostigmine @ ug / kg .", "sentence_id": 3}
+{"abstract_id": "24887252", "label": "methods", "text": "Postoperatively , monitoring of pain scores and time to first analgesic request and , total dose of analgesics administered in the first @ hours were recorded .", "sentence_id": 4}
+{"abstract_id": "24887252", "label": "results", "text": "All the patients participated throughout the study .", "sentence_id": 5}
+{"abstract_id": "24887252", "label": "results", "text": "There were no differences in the demographic characteristics ( age , weight , ASA status ) between the two groups .", "sentence_id": 6}
+{"abstract_id": "24887252", "label": "results", "text": "The mean duration of effective analgesia was significantly longer in group BN , @ @ min .", "sentence_id": 7}
+{"abstract_id": "24887252", "label": "results", "text": "compared to group B , @ @ mins , ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24887252", "label": "results", "text": "The analgesic requirement within the first @ hours postoperatively was also significantly reduced in group BN , p < @ .", "sentence_id": 9}
+{"abstract_id": "24887252", "label": "conclusions", "text": "The study shows that the addition of low dose neostigmine to caudal isobaric bupivacaine significantly prolonged the time to first analgesic request and hence significantly reduced postoperative analgesic requirement .", "sentence_id": 10}
+{"abstract_id": "25236187", "label": "background", "text": "The American College of Surgeons Oncology Group Z@ trial has been lauded as practice changing .", "sentence_id": 0}
+{"abstract_id": "25236187", "label": "background", "text": "We sought to identify its impact on breast cancer surgery in the community hospital setting .", "sentence_id": 1}
+{"abstract_id": "25236187", "label": "methods", "text": "A retrospective review was performed from @ community hospitals identifying patients with invasive breast cancer meeting the Z@ criteria .", "sentence_id": 2}
+{"abstract_id": "25236187", "label": "methods", "text": "The primary outcome measures were the rate of completion axillary lymph node dissection ( ALND ) and performance of intraoperative sentinel lymph node ( SLN ) analysis over time .", "sentence_id": 3}
+{"abstract_id": "25236187", "label": "results", "text": "A total of @,@ lumpectomies with SLN biopsies were performed with @ subjects meeting inclusion criteria .", "sentence_id": 4}
+{"abstract_id": "25236187", "label": "results", "text": "Performance of ALND ( P < @ ) and intraoperative SLN analysis ( P < @ ) declined during each time period .", "sentence_id": 5}
+{"abstract_id": "25236187", "label": "results", "text": "Patients more likely to undergo ALND included those with extracapsular extension ( odds ratio -LSB- OR -RSB- @ , @ % confidence interval -LSB- CI -RSB- @ to @ ) and those who underwent reoperative surgery ( OR @ , @ % CI @ to @ ) or intraoperative SLN analysis ( OR @ , @ % CI @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25236187", "label": "conclusions", "text": "American College of Surgeons Oncology Group Z@ trial has been rapidly practice changing in the community hospital setting .", "sentence_id": 7}
+{"abstract_id": "25639879", "label": "background", "text": "Indomethacin is a potent analgesic that , similar to other nonsteroidal anti-inflammatory drugs , is associated with serious dose-related adverse events .", "sentence_id": 0}
+{"abstract_id": "25639879", "label": "background", "text": "There is a need for newer nonsteroidal anti-inflammatory drug products with improved tolerability .", "sentence_id": 1}
+{"abstract_id": "25639879", "label": "background", "text": "Low-dose submicron indomethacin was developed using SoluMatrix Fine Particle Technology to enable treatment at lower doses than commercially available indomethacin drug products .", "sentence_id": 2}
+{"abstract_id": "25639879", "label": "background", "text": "This study evaluated the pharmacokinetics and safety of submicron indomethacin @ and @ mg compared with indomethacin @-mg capsules .", "sentence_id": 3}
+{"abstract_id": "25639879", "label": "methods", "text": "This was a phase @ , randomized , open-label , @-period , @-sequence , single-dose crossover study .", "sentence_id": 4}
+{"abstract_id": "25639879", "label": "methods", "text": "Forty healthy volunteers received low-dose submicron indomethacin @ - or @-mg capsules , or indomethacin @-mg capsules under fasting or fed conditions .", "sentence_id": 5}
+{"abstract_id": "25639879", "label": "methods", "text": "Pharmacokinetic parameters and safety were assessed .", "sentence_id": 6}
+{"abstract_id": "25639879", "label": "results", "text": "Comparable fasting peak plasma levels ( mean standard deviation ) were demonstrated for submicron indomethacin @ mg ( @ @ ng/ml ) and indomethacin @ mg ( @ @ ng/ml ) .", "sentence_id": 7}
+{"abstract_id": "25639879", "label": "results", "text": "The overall systemic exposure ( geometric least squares mean ; @ % CI ) was > @ % lower for submicron indomethacin @ mg ( @ ngh/mL ; @-@ @ ) compared with indomethacin @ mg ( @ ngh/ml ; @-@ @ ) under fasting conditions .", "sentence_id": 8}
+{"abstract_id": "25639879", "label": "results", "text": "Food delayed the rate but did not affect the extent of indomethacin absorption from submicron indomethacin @ mg .", "sentence_id": 9}
+{"abstract_id": "25639879", "label": "results", "text": "Submicron indomethacin @ mg administration resulted in earlier time to peak plasma levels ( median @ ; min-max @-@ @ hours ) under fasting conditions compared with indomethacin @ mg ( @ ; @-@ @ hours ) .", "sentence_id": 10}
+{"abstract_id": "25639879", "label": "results", "text": "Submicron indomethacin @ and @ mg were dose proportional and generally well tolerated .", "sentence_id": 11}
+{"abstract_id": "25639879", "label": "conclusions", "text": "Compared with indomethacin @ mg , submicron indomethacin @ mg achieved similar peak plasma concentrations , lower systemic exposure , and a faster time to peak plasma concentration , indicating rapid absorption .", "sentence_id": 12}
+{"abstract_id": "25639879", "label": "conclusions", "text": "The current formulation of low-dose submicron indomethacin has recently demonstrated efficacy in @ phase @ studies in patients with acute pain following bunionectomy and represents a new , low-dose treatment option for patients with acute pain .", "sentence_id": 13}
+{"abstract_id": "25675651", "label": "objective", "text": "To describe the profile of patients who participated in the Randomised Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil ( U-MDT/CT-BR ) and determine the level of satisfaction with a uniform therapy regimen , especially among paucibacillary patients .", "sentence_id": 0}
+{"abstract_id": "25675651", "label": "methods", "text": "This is a descriptive cross-sectional epidemiologic study nested in the wider U-MDT/CT-BR .", "sentence_id": 1}
+{"abstract_id": "25675651", "label": "methods", "text": "The study was conducted using a convenience sample composed of patients from the Dona Libnia Dermatology Centre in Fortaleza , Cear and from the Alfredo da Matta Foundation in Manaus , Amazonas in Brazil .", "sentence_id": 2}
+{"abstract_id": "25675651", "label": "methods", "text": "The absolute and relative frequencies of categorical variables and the median age were calculated .", "sentence_id": 3}
+{"abstract_id": "25675651", "label": "methods", "text": "Hypothesis testing was done using the Chi-squared and Mann-Whitney tests with a @ level of significance .", "sentence_id": 4}
+{"abstract_id": "25675651", "label": "results", "text": "Of the @ patients included in the clinical trial , @ were interviewed .", "sentence_id": 5}
+{"abstract_id": "25675651", "label": "results", "text": "The majority of patients were male ( @ % ) and multibacillary ( @ % ) with a median age of @ ( @-@ ) years .", "sentence_id": 6}
+{"abstract_id": "25675651", "label": "results", "text": "Most of the interviewees had not completed primary education ( @ % ) , earned an income below three times the minimum wage ( @ % ) , were non-smokers ( @ % ) , did not regularly consume alcohol ( @ % ) , had not experienced any leprosy-related discrimination ( @ % ) and showed a basic knowledge of the disease .", "sentence_id": 7}
+{"abstract_id": "25675651", "label": "results", "text": "With regards to paucibacillary patients , @ % and @ % of the PB U-MDT and PB R-MDT groups , respectively , indicated that they had not thought of defaulting treatment at any time .", "sentence_id": 8}
+{"abstract_id": "25675651", "label": "results", "text": "On a satisfaction scale of @-@ ( with five as the highest score ) , @ % of PB U-MDT and @ % of PB R-MDT patients gave a mark between three and five .", "sentence_id": 9}
+{"abstract_id": "25675651", "label": "conclusions", "text": "The data suggest that the introduction of clofazimine into the therapeutic regimen did not diminish the level of treatment satisfaction among PB patients .", "sentence_id": 10}
+{"abstract_id": "24832787", "label": "background", "text": "Circulating tumor cells ( CTCs ) have been shown to predict reduced survival outcomes in metastatic breast cancer .", "sentence_id": 0}
+{"abstract_id": "24832787", "label": "methods", "text": "CTCs were analyzed in @ patients with early breast cancer before adjuvant chemotherapy and in @ patients after chemotherapy using the CellSearch System .", "sentence_id": 1}
+{"abstract_id": "24832787", "label": "methods", "text": "After immuno-magnetic enrichment for cells expressing the epithelial-cell adhesion molecule , CTCs were defined as nucleated cells expressing cytokeratin and lacking CD@ .", "sentence_id": 2}
+{"abstract_id": "24832787", "label": "methods", "text": "The patients were followed for a median of @ months ( range = @-@ ) .", "sentence_id": 3}
+{"abstract_id": "24832787", "label": "methods", "text": "Kaplan-Meier analyses and the log-rank test were used for survival analyses .", "sentence_id": 4}
+{"abstract_id": "24832787", "label": "methods", "text": "All statistical tests were two-sided .", "sentence_id": 5}
+{"abstract_id": "24832787", "label": "results", "text": "Before chemotherapy , CTCs were detected in @ % of patients ( n = @ of @ ) , with @ % ( n = @ of @ ) of node-negative and @ % ( n = @ of @ ) of node-positive patients showing CTCs ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24832787", "label": "results", "text": "No association was found with tumor size , grading , or hormone receptor status .", "sentence_id": 7}
+{"abstract_id": "24832787", "label": "results", "text": "After chemotherapy , @ % of patients ( n = @ of @ ) were CTC positive .", "sentence_id": 8}
+{"abstract_id": "24832787", "label": "results", "text": "The presence of CTCs was associated with poor disease-free survival ( DFS ; P < @ ) , distant DFS ( P < @ ) , breast cancer-specific survival ( P = @ ) , and overall survival ( OS ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24832787", "label": "results", "text": "CTCs were confirmed as independent prognostic markers in multivariable analysis for DFS ( hazard ratio -LSB- HR -RSB- = @ ; @ % confidence interval -LSB- CI -RSB- = @ to @ ; P < @ ) and OS ( HR = @ ; @ % CI = @ to @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24832787", "label": "results", "text": "The prognosis was worst in patients with at least five CTCs per @ mL blood ( DFS : HR = @ , @ % CI = @ to @ ; OS : HR = @ , @ % CI = @ to @ ) .", "sentence_id": 11}
+{"abstract_id": "24832787", "label": "results", "text": "The presence of persisting CTCs after chemotherapy showed a negative influence on DFS ( HR = @ ; @ % CI = @ to @ ; P = @ ) and on OS ( HR = @ ; @ % CI = @ to @ ; P = @ ) CONCLUSIONS : These results suggest the independent prognostic relevance of CTCs both before and after adjuvant chemotherapy in a large prospective trial of patients with primary breast cancer .", "sentence_id": 12}
+{"abstract_id": "24462043", "label": "objective", "text": "Reduction of cardiovascular risk with high consumption of fish in diet is still a matter of debate , and concerns about heavy metal contamination have limited consumption of oily fish .", "sentence_id": 0}
+{"abstract_id": "24462043", "label": "objective", "text": "We aimed to evaluate the effect of regular ingestion of white fish on cardiovascular risk factors in patients with metabolic syndrome .", "sentence_id": 1}
+{"abstract_id": "24462043", "label": "results", "text": "Multicenter randomized crossover clinical trial including @ individuals with metabolic syndrome .", "sentence_id": 2}
+{"abstract_id": "24462043", "label": "results", "text": "An @-week only-one dietary intervention : @ g/d of white fish ( Namibia hake ) with advice on a healthy diet , compared with no fish or seafood with advice on a healthy diet .", "sentence_id": 3}
+{"abstract_id": "24462043", "label": "results", "text": "Outcomes were lipid profile , individual components of the metabolic syndrome , serum insulin concentrations , homeostasis model of insulin resistance , serum C-reactive protein and serum fatty acid levels .", "sentence_id": 4}
+{"abstract_id": "24462043", "label": "results", "text": "We found a significant lowering effect of the intervention with white fish on waist circumference ( P < @ ) and diastolic blood pressure ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24462043", "label": "results", "text": "A significant lowering effect was also shown after the dietary intervention with fish on serum LDL concentrations ( P = @ ) , whereas no significant effects were found on serum HDL or triglyceride concentrations .", "sentence_id": 6}
+{"abstract_id": "24462043", "label": "results", "text": "A significant rise ( P < @ ) in serum EPA and DHA fatty acids was observed following white fish consumption .", "sentence_id": 7}
+{"abstract_id": "24462043", "label": "results", "text": "Overall adherence to the intervention was good and no adverse events were found .", "sentence_id": 8}
+{"abstract_id": "24462043", "label": "conclusions", "text": "In individuals with metabolic syndrome , regular consumption of hake reduces LDL cholesterol concentrations , waist circumference and blood pressure components of the metabolic syndrome .", "sentence_id": 9}
+{"abstract_id": "24365274", "label": "background", "text": "Despite the popularity of hypnotherapy for smoking cessation , the efficacy of this method is unclear .", "sentence_id": 0}
+{"abstract_id": "24365274", "label": "background", "text": "We aimed to investigate the efficacy of a single-session of group hypnotherapy for smoking cessation compared to relaxation in Swiss adult smokers .", "sentence_id": 1}
+{"abstract_id": "24365274", "label": "methods", "text": "This was a cluster-randomised , parallel-group , controlled trial .", "sentence_id": 2}
+{"abstract_id": "24365274", "label": "methods", "text": "A single session of hypnosis or relaxation for smoking cessation was delivered to groups of smokers ( median size = @ ) .", "sentence_id": 3}
+{"abstract_id": "24365274", "label": "methods", "text": "Participants were @ smokers consuming @ cigarettes per day , willing to quit and not using cessation aids ( @ % females , M = @ years -LSB- SD = @ -RSB- , @ % Swiss ) .", "sentence_id": 4}
+{"abstract_id": "24365274", "label": "methods", "text": "Nicotine withdrawal , smoking abstinence self-efficacy , and adverse reactions were assessed at a @-week follow-up .", "sentence_id": 5}
+{"abstract_id": "24365274", "label": "methods", "text": "The main outcome , self-reported @-day point prevalence of smoking abstinence , was assessed at a @-month follow up .", "sentence_id": 6}
+{"abstract_id": "24365274", "label": "methods", "text": "Abstinence was validated through salivary analysis .", "sentence_id": 7}
+{"abstract_id": "24365274", "label": "methods", "text": "Secondary outcomes included number of cigarettes smoked per day , smoking abstinence self-efficacy , and nicotine withdrawal .", "sentence_id": 8}
+{"abstract_id": "24365274", "label": "results", "text": "At the @-month follow up , @ % in the hypnosis group and @ % in the relaxation group were abstinent .", "sentence_id": 9}
+{"abstract_id": "24365274", "label": "results", "text": "The intervention had no effect on smoking status ( p = @ ) or on the number of cigarettes smoked per day ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24365274", "label": "results", "text": "Smoking abstinence self-efficacy did not differ between the interventions ( p = @ ) at the @-week follow-up , but non-smokers in the hypnosis group experienced reduced withdrawal ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24365274", "label": "results", "text": "Both interventions produced few adverse reactions ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24365274", "label": "conclusions", "text": "A single session of group hypnotherapy does not appear to be more effective for smoking cessation than a group relaxation session .", "sentence_id": 13}
+{"abstract_id": "25323219", "label": "objective", "text": "A review on headache and insomnia revealed that insomnia is a risk factor for increased headache frequency and headache intensity in migraineurs .", "sentence_id": 0}
+{"abstract_id": "25323219", "label": "objective", "text": "The authors designed a randomized , double blind , placebo-controlled , parallel-group , pilot study in which migraineurs who also had insomnia were enrolled , to test this observation .", "sentence_id": 1}
+{"abstract_id": "25323219", "label": "methods", "text": "In the study , the authors treated @ subjects with IHS-II migraine with and/or without aura and with DSM-IV primary insomnia for @ weeks with @ mg eszopiclone ( Lunesta ( ) ) or placebo at bedtime .", "sentence_id": 2}
+{"abstract_id": "25323219", "label": "methods", "text": "The treatment was preceded by a @-week baseline period and followed by a @-week run-out period .", "sentence_id": 3}
+{"abstract_id": "25323219", "label": "results", "text": "Of the @ subjects treated , @ were evaluable , @ in the eszopiclone group , and @ in the placebo group .", "sentence_id": 4}
+{"abstract_id": "25323219", "label": "results", "text": "At baseline , the groups were comparable except for sleep latency .", "sentence_id": 5}
+{"abstract_id": "25323219", "label": "results", "text": "Of the three remaining sleep variables , total sleep time , nighttime awakenings , and sleep quality , the number of nighttime awakenings during the @-week treatment period was significantly lower in the eszopiclone group than in the placebo group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25323219", "label": "results", "text": "Of the three daytime variables , alertness , fatigue , and functioning , this was also the case for fatigue ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25323219", "label": "results", "text": "The headache variables , frequency , duration , and intensity , did not show a difference from placebo during the @-week treatment period .", "sentence_id": 8}
+{"abstract_id": "25323219", "label": "conclusions", "text": "The study did not meet primary endpoint , that is , the difference in total sleep time during the @-week treatment period between eszopiclone and placebo was less than @ minutes .", "sentence_id": 9}
+{"abstract_id": "25323219", "label": "conclusions", "text": "Therefore , it failed to answer the question as to whether insomnia is , indeed , a risk factor for increased headache frequency and headache intensity in migraineurs .", "sentence_id": 10}
+{"abstract_id": "24465617", "label": "background", "text": "The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance ( RDA ) vitamins in slowing HIV immune deficiency progression in ART-nave people with HIV infection .", "sentence_id": 0}
+{"abstract_id": "24465617", "label": "objective", "text": "We planned analysis of the first @ participants to determine the baseline prevalence of serum micronutrient deficiencies and correlates , as well as tolerance and adherence to study interventions .", "sentence_id": 1}
+{"abstract_id": "24465617", "label": "methods", "text": "Participants receive eight capsules twice daily of @ ) high-dose or @ ) RDA supplements for two years and are followed-up quarterly for measures of immune deficiency progression , safety and tolerability .", "sentence_id": 2}
+{"abstract_id": "24465617", "label": "methods", "text": "Regression analysis was used to identify correlates of micronutrient levels at baseline .", "sentence_id": 3}
+{"abstract_id": "24465617", "label": "methods", "text": "Adherence was measured by residual pill count , self-report using the General Treatment Scale ( GTS ) and short-term recall HIV Adherence Treatment Scale ( HATS ) .", "sentence_id": 4}
+{"abstract_id": "24465617", "label": "results", "text": "Prior micronutrient supplementation ( within @ days ) was @ % at screening and @ % of study population , and was not correlated with baseline micronutrient levels .", "sentence_id": 5}
+{"abstract_id": "24465617", "label": "results", "text": "Low levels were frequent for carotene ( @ % < @ nmol/L ) , vitamin D ( @ % < @ nmol/L ) and serum folate ( @ % < @ nmol/L ) .", "sentence_id": 6}
+{"abstract_id": "24465617", "label": "results", "text": "The proportion with B@ deficiency ( < @ pmol/L ) was @ % .", "sentence_id": 7}
+{"abstract_id": "24465617", "label": "results", "text": "Lower baseline levels of B@ correlated lower baseline CD@ count ( r = @ , p = @ ) with a @ pmol/L reduction in B@ per @ cells/L CD@ .", "sentence_id": 8}
+{"abstract_id": "24465617", "label": "results", "text": "Vitamin D levels were higher in men ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24465617", "label": "results", "text": "After a median follow-up of @ years , there were @ ( @ % ) early withdrawals from the study treatment .", "sentence_id": 10}
+{"abstract_id": "24465617", "label": "results", "text": "Mean treatment adherence using pill count was @ % .", "sentence_id": 11}
+{"abstract_id": "24465617", "label": "results", "text": "Subjective adherence by the GTS was @ % and was moderately but significantly correlated with pill count ( r = @ , p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24465617", "label": "results", "text": "Adherence based on short-term recall ( HATS ) was > @ % in @ % of participants .", "sentence_id": 13}
+{"abstract_id": "24465617", "label": "conclusions", "text": "Micronutrient levels in asymptomatic HIV + persons are in keeping with population norms , but micronutrient deficiencies are frequent .", "sentence_id": 14}
+{"abstract_id": "24465617", "label": "conclusions", "text": "Adherence levels are high , and will permit a valid evaluation of treatment effects .", "sentence_id": 15}
+{"abstract_id": "24800381", "label": "background", "text": "Gestational diabetes mellitus ( GDM ) increases risks for type @ diabetes and cardiovascular diseases .", "sentence_id": 0}
+{"abstract_id": "24800381", "label": "background", "text": "Low glycaemic index ( GI ) diets improve cardio-metabolic outcomes in insulin-resistant individuals .", "sentence_id": 1}
+{"abstract_id": "24800381", "label": "background", "text": "We examined the feasibility of lowering GI through GI-based-education among Asian post-GDM women .", "sentence_id": 2}
+{"abstract_id": "24800381", "label": "methods", "text": "A @-month investigation was carried out on @ Malaysian women with a mean age of @ + / - @ years and a history of GDM .", "sentence_id": 3}
+{"abstract_id": "24800381", "label": "methods", "text": "Subjects were randomised into two groups : LGIE and CHDR .", "sentence_id": 4}
+{"abstract_id": "24800381", "label": "methods", "text": "The CHDR group received conventional healthy dietary recommendations only .", "sentence_id": 5}
+{"abstract_id": "24800381", "label": "methods", "text": "The LGIE group received GI based-education in addition to conventional healthy dietary recommendations .", "sentence_id": 6}
+{"abstract_id": "24800381", "label": "methods", "text": "At baseline and after @-months , dietary intake of energy and macronutrient intakes including GI diet and glycaemic load was assessed using @-day food records .", "sentence_id": 7}
+{"abstract_id": "24800381", "label": "methods", "text": "Diabetes-Diet and GI-concept scores and physical activity levels were assessed using a questionnaire .", "sentence_id": 8}
+{"abstract_id": "24800381", "label": "methods", "text": "Adherence to dietary instructions was measured at the end of @ months .", "sentence_id": 9}
+{"abstract_id": "24800381", "label": "results", "text": "At the end of @ months , the LGIE group had significant reductions in energy intake ( @ + / - @ Kcal , P = @ , ES = @ ) , total carbohydrate ( @ + / - @ g , P = @ , ES = @ ) , GI ( @ + / - @ , P = @ , ES = @ ) and GL ( @ + / - @ , P = @ , ES = @ ) and significant increases in protein ( @ + / - @ g , @ , ES = @ ) and diet fibre ( @ + / - @ g , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24800381", "label": "results", "text": "The CHDR group had a significant reduction in fat only ( @ + / - @ g , P = @ , ES = @ ) .", "sentence_id": 11}
+{"abstract_id": "24800381", "label": "results", "text": "There was a @ % increase in GI-concept scores in the LGIE group ( p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24800381", "label": "results", "text": "Changes in GI-concept scores correlated significantly to the reduction in dietary GI ( r = -@ , P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24800381", "label": "results", "text": "Dietary adherence was comparable in both groups .", "sentence_id": 14}
+{"abstract_id": "24800381", "label": "conclusions", "text": "GI-education improves GI-concept knowledge and helps lower dietary glycaemic index among women with a history of GDM .", "sentence_id": 15}
+{"abstract_id": "24428857", "label": "objective", "text": "To determine whether single-dose tranexamic acid given intravenously immediately before surgery for presumed advanced ovarian cancer reduces perioperative blood loss and blood transfusions .", "sentence_id": 0}
+{"abstract_id": "24428857", "label": "methods", "text": "A randomized double-blind , placebo-controlled multicenter study .", "sentence_id": 1}
+{"abstract_id": "24428857", "label": "methods", "text": "Two university hospitals and two central hospitals in the southeast health region of Sweden .", "sentence_id": 2}
+{"abstract_id": "24428857", "label": "methods", "text": "One hundred women with presumed advanced ovarian cancer scheduled for radical debulking surgery between March @ and May @ who complied with inclusion/exclusion criteria were randomized ; @ were allocated to receive tranexamic acid and @ to receive placebo .", "sentence_id": 3}
+{"abstract_id": "24428857", "label": "methods", "text": "Analysis was performed according to intention-to-treat principles .", "sentence_id": 4}
+{"abstract_id": "24428857", "label": "methods", "text": "The volume of tranexamic acid ( @mg/kg body weight , @mg/mL tranexamic acid ) or the same volume of placebo ( @ % NaCl ) was added to a @-mL saline solution plastic bag .", "sentence_id": 5}
+{"abstract_id": "24428857", "label": "methods", "text": "The study medication was given immediately before the start of surgery .", "sentence_id": 6}
+{"abstract_id": "24428857", "label": "methods", "text": "Data were analyzed by means of non-parametric statistics and multivariate models adjusted for confounding factors .", "sentence_id": 7}
+{"abstract_id": "24428857", "label": "methods", "text": "Blood loss and red blood cell transfusions .", "sentence_id": 8}
+{"abstract_id": "24428857", "label": "results", "text": "The total blood loss volume and transfusion rate were significantly lower in the tranexamic acid group compared with the placebo group .", "sentence_id": 9}
+{"abstract_id": "24428857", "label": "results", "text": "Median total blood loss was @ and @mL , respectively ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24428857", "label": "results", "text": "Fifteen ( @ % ) and @ ( @ % ) , respectively received transfusions ( odds ratio @ ; upper @ % CI @ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24428857", "label": "conclusions", "text": "A single dose of tranexamic acid given immediately before surgery reduces blood loss and transfusion rates significantly in advanced ovarian cancer surgery .", "sentence_id": 12}
+{"abstract_id": "24428857", "label": "conclusions", "text": "Tranexamic acid may be recommended as standard prophylactic treatment in advanced ovarian cancer surgery .", "sentence_id": 13}
+{"abstract_id": "25976288", "label": "objective", "text": "To determine the effectiveness of a physical activity intervention for smoking cessation during pregnancy .", "sentence_id": 0}
+{"abstract_id": "25976288", "label": "methods", "text": "Parallel group , randomised controlled , multicentre trial .", "sentence_id": 1}
+{"abstract_id": "25976288", "label": "methods", "text": "@ hospitals in England , April @ to January @ .", "sentence_id": 2}
+{"abstract_id": "25976288", "label": "methods", "text": "@ pregnant smokers , aged @-@ years and at @-@ weeks ' gestation , who smoked at least one cigarette daily and were prepared to quit smoking one week after enrollment were randomised ( @:@ ) ; @ were included in the intention to treat analyses , with @ assigned to the physical activity group .", "sentence_id": 3}
+{"abstract_id": "25976288", "label": "methods", "text": "Interventions began one week before a target quit date .", "sentence_id": 4}
+{"abstract_id": "25976288", "label": "methods", "text": "Participants were randomised to six weekly sessions of behavioural support for smoking cessation ( control ) or to this support plus @ sessions combining supervised treadmill exercise and physical activity consultations .", "sentence_id": 5}
+{"abstract_id": "25976288", "label": "methods", "text": "The primary outcome was continuous smoking abstinence from the target quit date until end of pregnancy , validated by exhaled carbon monoxide or salivary cotinine levels .", "sentence_id": 6}
+{"abstract_id": "25976288", "label": "methods", "text": "To assess adherence , levels of moderate-vigorous intensity physical activity were self reported and in a @ % ( n = @ ) random subsample of participants , physical activity was objectively measured by an accelerometer .", "sentence_id": 7}
+{"abstract_id": "25976288", "label": "results", "text": "No significant difference was found in rates of smoking abstinence at end of pregnancy between the physical activity and control groups ( @ % v @ % ; odds ratio @ , @ % confidence interval @ to @ ) .", "sentence_id": 8}
+{"abstract_id": "25976288", "label": "results", "text": "For the physical activity group compared with the control group , there was a @ % ( @ % confidence interval @ % to @ % ) , @ % ( @ % to @ % ) , and @ % ( @ % to @ % ) greater increase in self reported minutes carrying out physical activity per week from baseline to one week , four weeks , and six weeks post-quit day , respectively .", "sentence_id": 9}
+{"abstract_id": "25976288", "label": "results", "text": "According to the accelerometer data there was no significant difference in physical activity levels between the groups .", "sentence_id": 10}
+{"abstract_id": "25976288", "label": "results", "text": "Participants attended a median of four treatment sessions in the intervention group and three in the control group .", "sentence_id": 11}
+{"abstract_id": "25976288", "label": "results", "text": "Adverse events and birth outcomes were similar between the two groups , except for significantly more caesarean births in the control group than in the physical activity group ( @ % v @ % , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25976288", "label": "conclusions", "text": "Adding a physical activity intervention to behavioural smoking cessation support for pregnant women did not increase cessation rates at end of pregnancy .", "sentence_id": 13}
+{"abstract_id": "25976288", "label": "conclusions", "text": "During pregnancy , physical activity is not recommended for smoking cessation but remains indicated for general health benefits .", "sentence_id": 14}
+{"abstract_id": "25976288", "label": "conclusions", "text": "Trial registration Current Controlled Trials ISRCTN@ .", "sentence_id": 15}
+{"abstract_id": "26179201", "label": "background", "text": "Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer ; expression of VEGF and its receptors is associated with adverse outcomes .", "sentence_id": 0}
+{"abstract_id": "26179201", "label": "background", "text": "We aimed to assess the effect of the addition of cediranib ( an oral inhibitor of VEGF receptor @ , @ , and @ ) to cisplatin and gemcitabine on progression-free survival .", "sentence_id": 1}
+{"abstract_id": "26179201", "label": "methods", "text": "In this multicentre , placebo-controlled , randomised phase @ study , we recruited patients aged @ years or older with histologically confirmed or cytologically confirmed advanced biliary tract cancer from hepatobiliary oncology referral centres in the UK .", "sentence_id": 2}
+{"abstract_id": "26179201", "label": "methods", "text": "Patients were eligible if they had an ECOG performance status of @-@ and an estimated life expectancy of longer than @ months .", "sentence_id": 3}
+{"abstract_id": "26179201", "label": "methods", "text": "Patients were given first-line cisplatin and gemcitabine chemotherapy ( @ mg/m ( @ ) cisplatin and @ mg/m ( @ ) gemcitabine -LSB- on days @ and @ every @ days , for up to eight cycles -RSB- ) with either @ mg oral cediranib or placebo once a day until disease progression .", "sentence_id": 4}
+{"abstract_id": "26179201", "label": "methods", "text": "We randomly assigned patients ( @:@ ) with a minimisation algorithm , incorporating the stratification factors : extent of disease , primary disease site , previous treatment , ECOG performance status , and centre .", "sentence_id": 5}
+{"abstract_id": "26179201", "label": "methods", "text": "The primary endpoint was progression-free survival in the intention-to-treat population .", "sentence_id": 6}
+{"abstract_id": "26179201", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ , and was closed on Sept @ , @ ; results of the final analysis for the primary endpoint are presented .", "sentence_id": 7}
+{"abstract_id": "26179201", "label": "results", "text": "Between April @ , @ , and Sept @ , @ , we enrolled @ patients ( @ in each group ) .", "sentence_id": 8}
+{"abstract_id": "26179201", "label": "results", "text": "With a median follow-up of @ months ( IQR @-@ ) , median progression-free survival was @ months ( @ % CI @-@ ) in the cediranib group and @ months ( @-@ ) in the placebo group ( HR @ , @ % CI @-@ , @ % CI @-@ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "26179201", "label": "results", "text": "Patients who received cediranib had more grade @-@ toxic effects than did patients who received placebo : hypertension ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; p = @ ) , diarrhoea ( eight -LSB- @ % -RSB- vs two -LSB- @ % -RSB- ; p = @ ) ; platelet count decreased ( ten -LSB- @ % -RSB- vs four -LSB- @ % -RSB- ; p = @ ) , white blood cell decreased ( @ -LSB- @ % -RSB- vs seven -LSB- @ % -RSB- ; p = @ ) and fatigue ( @ -LSB- @ % -RSB- vs seven -LSB- @ % -RSB- ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "26179201", "label": "conclusions", "text": "Cediranib did not improve the progression-free survival of patients with advanced biliary tract cancer in combination with cisplatin and gemcitabine , which remains the standard of care .", "sentence_id": 11}
+{"abstract_id": "26179201", "label": "conclusions", "text": "Although patients in the cediranib group had more adverse events , we recorded no unexpected toxic effects .", "sentence_id": 12}
+{"abstract_id": "26179201", "label": "conclusions", "text": "The role of VEGF inhibition in addition to chemotherapy for patients with advanced biliary tract cancer remains investigational .", "sentence_id": 13}
+{"abstract_id": "25385878", "label": "background", "text": "In the United Kingdom , licensed nicotine-containing products can be recommended to reduce the harm associated with smoking .", "sentence_id": 0}
+{"abstract_id": "25385878", "label": "background", "text": "Many smokers find currently available nicotine replacement products unsatisfactory .", "sentence_id": 1}
+{"abstract_id": "25385878", "label": "background", "text": "The arterial and venous pharmacokinetics ( PK ) of nicotine delivered via a novel inhaler device were determined .", "sentence_id": 2}
+{"abstract_id": "25385878", "label": "methods", "text": "Results are reported for Parts A ( N = @ ) and C ( N = @ ) of a @-part ( A-D ) Phase I study .", "sentence_id": 3}
+{"abstract_id": "25385878", "label": "methods", "text": "Participants ( @-@ years , @ cigarettes/day , smoking within @ hr of waking , expired carbon monoxide > @ ppm on screening ) orally inhaled @ single doses of nicotine ( @ of @ dose levels -LSB- @ , @ , and @ mg -RSB- ) ( Part A ) and repeated hourly doses of @ mg nicotine for @ hr ( Part C ) , via the novel device .", "sentence_id": 4}
+{"abstract_id": "25385878", "label": "methods", "text": "Arterial and venous PK and tolerability were assessed .", "sentence_id": 5}
+{"abstract_id": "25385878", "label": "results", "text": "In Part A , mean arterial plasma nicotine concentrations at @ min after the start of inhalation were @ , @ , and @ ng/mL for the @ , @ , and @ mg doses , respectively .", "sentence_id": 6}
+{"abstract_id": "25385878", "label": "results", "text": "Mean maximum arterial plasma nicotine concentrations ( C ( max ) ) were @ , @ , and @ ng/mL and mean times to C ( max ) were @ , @ , and @ min after the start of inhalation for the @ , @ , and @ mg doses , respectively .", "sentence_id": 7}
+{"abstract_id": "25385878", "label": "results", "text": "In Part C , the mean pre - and postdose venous plasma nicotine concentration increased steadily and fluctuated in the range @-@ mg/mL after @ hr .", "sentence_id": 8}
+{"abstract_id": "25385878", "label": "results", "text": "The novel device was well tolerated ; most adverse events were mild .", "sentence_id": 9}
+{"abstract_id": "25385878", "label": "conclusions", "text": "The novel inhaler device delivers nicotine rapidly into the systemic circulation and offers a viable alternative to cigarettes for those finding it difficult to quit the behavioral and sensorial aspects of smoking .", "sentence_id": 10}
+{"abstract_id": "24821196", "label": "background", "text": "The N-methyl-D-aspartate glutamate receptor antagonist ketamine , delivered via an intravenous route , has shown rapid antidepressant effects in patients with treatment-resistant depression .", "sentence_id": 0}
+{"abstract_id": "24821196", "label": "background", "text": "The current study was designed to test the safety , tolerability , and efficacy of intranasal ketamine in patients with depression who had failed at least one prior antidepressant trial .", "sentence_id": 1}
+{"abstract_id": "24821196", "label": "methods", "text": "In a randomized , double-blind , crossover study , @ patients with major depression were randomly assigned , and @ completed @ treatment days with intranasal ketamine hydrochloride ( @ mg ) or saline solution .", "sentence_id": 2}
+{"abstract_id": "24821196", "label": "methods", "text": "The primary efficacy outcome measure was change in depression severity @ hours after ketamine or placebo , measured using the Montgomery-sberg Depression Rating Scale .", "sentence_id": 3}
+{"abstract_id": "24821196", "label": "methods", "text": "Secondary outcomes included persistence of benefit , changes in self-reports of depression , changes in anxiety , and proportion of responders .", "sentence_id": 4}
+{"abstract_id": "24821196", "label": "methods", "text": "Potential psychotomimetic , dissociative , hemodynamic , and general adverse effects associated with ketamine were also measured .", "sentence_id": 5}
+{"abstract_id": "24821196", "label": "results", "text": "Patients showed significant improvement in depressive symptoms at @ hours after ketamine compared to placebo ( t = @ , p < @ ; estimated mean Montgomery-sberg Depression Rating Scale score difference of @ @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24821196", "label": "results", "text": "Response criteria were met by @ of @ patients ( @ % ) @ hours after ketamine administration compared with @ of @ ( @ % ) after placebo ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24821196", "label": "results", "text": "Intranasal ketamine was well tolerated with minimal psychotomimetic or dissociative effects and was not associated with clinically significant changes in hemodynamic parameters .", "sentence_id": 8}
+{"abstract_id": "24821196", "label": "conclusions", "text": "This study provides the first controlled evidence for the rapid antidepressant effects of intranasal ketamine .", "sentence_id": 9}
+{"abstract_id": "24821196", "label": "conclusions", "text": "Treatment was associated with minimal adverse effects .", "sentence_id": 10}
+{"abstract_id": "24821196", "label": "conclusions", "text": "If replicated , these findings may lead to novel approaches to the pharmacologic treatment of patients with major depression .", "sentence_id": 11}
+{"abstract_id": "24902920", "label": "background", "text": "High blood pressure is an important public health concern because it is highly prevalent and a risk factor for adverse health outcomes , including coronary heart disease , stroke , decompensated heart failure , chronic kidney disease , and decline in cognitive function .", "sentence_id": 0}
+{"abstract_id": "24902920", "label": "background", "text": "Observational studies show a progressive increase in risk associated with blood pressure above @/@ mm Hg .", "sentence_id": 1}
+{"abstract_id": "24902920", "label": "background", "text": "Prior research has shown that reducing elevated systolic blood pressure lowers the risk of subsequent clinical complications from cardiovascular disease .", "sentence_id": 2}
+{"abstract_id": "24902920", "label": "background", "text": "However , the optimal systolic blood pressure to reduce blood pressure-related adverse outcomes is unclear , and the benefit of treating to a level of systolic blood pressure well below @ mm Hg has not been proven in a large , definitive clinical trial .", "sentence_id": 3}
+{"abstract_id": "24902920", "label": "objective", "text": "To describe the design considerations of the Systolic Blood Pressure Intervention Trial ( SPRINT ) and the baseline characteristics of trial participants .", "sentence_id": 4}
+{"abstract_id": "24902920", "label": "methods", "text": "The Systolic Blood Pressure Intervention Trial is a multicenter , randomized , controlled trial that compares two strategies for treating systolic blood pressure : one targets the standard target of < @ mm Hg , and the other targets a more intensive target of < @ mm Hg .", "sentence_id": 5}
+{"abstract_id": "24902920", "label": "methods", "text": "Enrollment focused on volunteers of age @ years ( no upper limit ) with an average baseline systolic blood pressure @ mm Hg and evidence of cardiovascular disease , chronic kidney disease , @-year Framingham cardiovascular disease risk score @ % , or age @ years .", "sentence_id": 6}
+{"abstract_id": "24902920", "label": "methods", "text": "The Systolic Blood Pressure Intervention Trial recruitment also targeted three pre-specified subgroups : participants with chronic kidney disease ( estimated glomerular filtration rate < @ mL/min/@ @ m ( @ ) ) , participants with a history of cardiovascular disease , and participants @ years of age or older .", "sentence_id": 7}
+{"abstract_id": "24902920", "label": "methods", "text": "The primary outcome is first the occurrence of a myocardial infarction ( MI ) , acute coronary syndrome , stroke , heart failure , or cardiovascular disease death .", "sentence_id": 8}
+{"abstract_id": "24902920", "label": "methods", "text": "Secondary outcomes include all-cause mortality , decline in kidney function or development of end-stage renal disease , incident dementia , decline in cognitive function , and small-vessel cerebral ischemic disease .", "sentence_id": 9}
+{"abstract_id": "24902920", "label": "results", "text": "Between @ November @ and @ March @ , Systolic Blood Pressure Intervention Trial recruited and randomized @ people at @ clinics , including @ women , @ with chronic kidney disease , @ with a history of cardiovascular disease , @ minorities , and @ @ years of age .", "sentence_id": 10}
+{"abstract_id": "24902920", "label": "conclusions", "text": "Although the overall recruitment target was met , the numbers recruited in the high-risk subgroups were lower than planned .", "sentence_id": 11}
+{"abstract_id": "24902920", "label": "conclusions", "text": "The Systolic Blood Pressure Intervention Trial will provide important information on the risks and benefits of intensive blood pressure treatment targets in a diverse sample of high-risk participants , including those with prior cardiovascular disease , chronic kidney disease , and those aged @ years .", "sentence_id": 12}
+{"abstract_id": "25046950", "label": "objective", "text": "To observe the clinical effect of Shen-reinforcing and menstrual cycle-regulating therapy ( SRMCRT ) combined with Western medicine ( WM ) in treating decline in ovarian reserve ( DOR ) .", "sentence_id": 0}
+{"abstract_id": "25046950", "label": "methods", "text": "Totally @ patients with DOR were assigned to the traditional Chinese medicine combined WM group ( abbreviated as IM group , @ cases ) , and the WM group ( @ cases ) according to random digit table method .", "sentence_id": 1}
+{"abstract_id": "25046950", "label": "methods", "text": "Patients in the WM group were treated with hormone replacement therapy , while those in the IM group additionally received SRMCRT .", "sentence_id": 2}
+{"abstract_id": "25046950", "label": "methods", "text": "The therapeutic course for all was @ consecutive months .", "sentence_id": 3}
+{"abstract_id": "25046950", "label": "methods", "text": "The therapeutic efficacy was compared between the two groups .", "sentence_id": 4}
+{"abstract_id": "25046950", "label": "methods", "text": "The serum levels of follicle stimulating hormone ( FSH ) , FSH/luteinizing hormone ( LH ) , and estradiol ( E@ ) , as well as the development of sinus follicles were compared between before and after treatment in the two groups .", "sentence_id": 5}
+{"abstract_id": "25046950", "label": "results", "text": "The therapeutic effective rate was @ % in the IM group , higher than that of the WM group ( @ % , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25046950", "label": "results", "text": "The serum levels of FSH , FSH/LH , and E@ decreased ( P < @ ) and the number of the sinus follicle increased ( P < @ ) in the two groups after treatment .", "sentence_id": 7}
+{"abstract_id": "25046950", "label": "results", "text": "Besides , IM was superior in decreasing serum levels of FSH and FSH/LH , and increasing the number of the sinus follicle ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25046950", "label": "conclusions", "text": "SRMCRT was an effective method for treating ROD .", "sentence_id": 9}
+{"abstract_id": "25046950", "label": "conclusions", "text": "IM was superior in decreasing serum levels of FSH and FSH/LH , and increasing the number of the sinus follicle .", "sentence_id": 10}
+{"abstract_id": "25213687", "label": "background", "text": "Animal studies suggest that the renin-angiotensin-aldosterone system is involved in neurocognitive function and the response to antihypertensive therapy .", "sentence_id": 0}
+{"abstract_id": "25213687", "label": "background", "text": "We investigated the impact of circulating aldosterone and renin activity on cognition and cerebral hemodynamics at baseline and after antihypertensive therapy for @ year .", "sentence_id": 1}
+{"abstract_id": "25213687", "label": "methods", "text": "Participants were older adults ( n = @ ; mean age = @ years ) enrolled in a clinical trial .", "sentence_id": 2}
+{"abstract_id": "25213687", "label": "methods", "text": "Routine antihypertensive medications were replaced with the study regimen to achieve a blood pressure < @/@ mm Hg .", "sentence_id": 3}
+{"abstract_id": "25213687", "label": "methods", "text": "Executive function , memory , cerebral hemodynamics ( blood flow velocity ) , CO@ vasoreactivity ( measured using transcranial Doppler ultrasonography ) , plasma renin activity , and aldosterone were measured at baseline and at @ and @ months after the initiation of treatment .", "sentence_id": 4}
+{"abstract_id": "25213687", "label": "results", "text": "At baseline , higher levels of circulating aldosterone were associated with lower blood flow velocity ( = -@ ; P = @ ) , lower CO@ vasoreactivity ( = -@ ; P = @ ) , and decreased autoregulation abilities ( = -@ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25213687", "label": "results", "text": "Those with higher levels of aldosterone at baseline demonstrated the greatest improvement in executive function ( P = @ for the aldosterone effect ) and in CO@ vasoreactivity ( P = @ for the aldosterone effect ) after @ months of lowering blood pressure ( < @/@ mm Hg ) .", "sentence_id": 6}
+{"abstract_id": "25213687", "label": "results", "text": "Plasma renin activity was not associated with any of the measures .", "sentence_id": 7}
+{"abstract_id": "25213687", "label": "conclusions", "text": "Higher levels of aldosterone may be associated with decreased cerebrovascular function in hypertension .", "sentence_id": 8}
+{"abstract_id": "25213687", "label": "conclusions", "text": "Those with higher aldosterone levels may benefit the most from lowering blood pressure .", "sentence_id": 9}
+{"abstract_id": "25213687", "label": "conclusions", "text": "The role of aldosterone in brain health warrants further investigation in a larger trial .", "sentence_id": 10}
+{"abstract_id": "25509734", "label": "objective", "text": "To compare the difference in the clinical efficacy on cervical spondylosis between acupuncture at three lines of cervical Jiaji ( EX-B @ ) and oral administration of jingfukang granules .", "sentence_id": 0}
+{"abstract_id": "25509734", "label": "methods", "text": "Three hundred cases of cervical spondylosis were divided into an acupuncture group and a medication group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25509734", "label": "methods", "text": "In the acupuncture group , according to the different types of cervical spondylosis , acupuncture was applied at three lines of cervical Jiaji ( EX-B @ ) , once a day .", "sentence_id": 2}
+{"abstract_id": "25509734", "label": "methods", "text": "In the medication group , jingfukang granules were prescribed for oral administration , one bag each time , three times a day .", "sentence_id": 3}
+{"abstract_id": "25509734", "label": "methods", "text": "The treatment of ten days made one session in the two groups and two sessions were required totally .", "sentence_id": 4}
+{"abstract_id": "25509734", "label": "methods", "text": "Before and after two sessions of treatment , the clinical assessment scale for cervical spondylosis ( CASCS ) was adopted to evaluate the score of subjective symptoms , clinical physical signs and adaptability as well as the total score in the patients of the two groups and the efficacy was compared .", "sentence_id": 5}
+{"abstract_id": "25509734", "label": "results", "text": "The patients ' symptoms and physical signs were alleviated , the adaptability was improved and the score of each item and the total score were increased in the two groups after treatment ( all P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25509734", "label": "results", "text": "The improvements in the acupuncture group were better than those in the medication group ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25509734", "label": "results", "text": "The curative and markedly effective rate was @ % ( @/@ ) in the acupuncture group , better than @ % ( @/@ ) in the medication group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25509734", "label": "conclusions", "text": "Acupuncture at three lines of cervical Jiaji ( EX-B @ ) achieves the significant clinical efficacy on cervical spondylosis .", "sentence_id": 9}
+{"abstract_id": "25509734", "label": "conclusions", "text": "This therapy is superior to relieving symptoms and physical signs and recovering adaptability as compared with jingfukang granules .", "sentence_id": 10}
+{"abstract_id": "25981812", "label": "background", "text": "The standard of care for operable , stage I , non-small-cell lung cancer ( NSCLC ) is lobectomy with mediastinal lymph node dissection or sampling .", "sentence_id": 0}
+{"abstract_id": "25981812", "label": "background", "text": "Stereotactic ablative radiotherapy ( SABR ) for inoperable stage I NSCLC has shown promising results , but two independent , randomised , phase @ trials of SABR in patients with operable stage I NSCLC ( STARS and ROSEL ) closed early due to slow accrual .", "sentence_id": 1}
+{"abstract_id": "25981812", "label": "background", "text": "We aimed to assess overall survival for SABR versus surgery by pooling data from these trials .", "sentence_id": 2}
+{"abstract_id": "25981812", "label": "methods", "text": "Eligible patients in the STARS and ROSEL studies were those with clinical T@-@a ( < @ cm ) , N@M@ , operable NSCLC .", "sentence_id": 3}
+{"abstract_id": "25981812", "label": "methods", "text": "Patients were randomly assigned in a @:@ ratio to SABR or lobectomy with mediastinal lymph node dissection or sampling .", "sentence_id": 4}
+{"abstract_id": "25981812", "label": "methods", "text": "We did a pooled analysis in the intention-to-treat population using overall survival as the primary endpoint .", "sentence_id": 5}
+{"abstract_id": "25981812", "label": "methods", "text": "Both trials are registered with ClinicalTrials.gov ( STARS : NCT@ ; ROSEL : NCT@ ) .", "sentence_id": 6}
+{"abstract_id": "25981812", "label": "results", "text": "@ patients were enrolled and randomly assigned ( @ to SABR and @ to surgery ) .", "sentence_id": 7}
+{"abstract_id": "25981812", "label": "results", "text": "Median follow-up was @ months ( IQR @-@ ) for the SABR group and @ months ( @-@ ) for the surgery group .", "sentence_id": 8}
+{"abstract_id": "25981812", "label": "results", "text": "Six patients in the surgery group died compared with one patient in the SABR group .", "sentence_id": 9}
+{"abstract_id": "25981812", "label": "results", "text": "Estimated overall survival at @ years was @ % ( @ % CI @-@ ) in the SABR group compared with @ % ( @-@ ) in the surgery group ( hazard ratio -LSB- HR -RSB- @ -LSB- @ % CI @-@ -RSB- , log-rank p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25981812", "label": "results", "text": "Recurrence-free survival at @ years was @ % ( @ % CI @-@ ) in the SABR group and @ % ( @-@ ) in the surgery group ( HR @ -LSB- @ % CI @-@ -RSB- , log-rank p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25981812", "label": "results", "text": "In the surgery group , one patient had regional nodal recurrence and two had distant metastases ; in the SABR group , one patient had local recurrence , four had regional nodal recurrence , and one had distant metastases .", "sentence_id": 12}
+{"abstract_id": "25981812", "label": "results", "text": "Three ( @ % ) patients in the SABR group had grade @ treatment-related adverse events ( three -LSB- @ % -RSB- chest wall pain , two -LSB- @ % -RSB- dyspnoea or cough , and one -LSB- @ % -RSB- fatigue and rib fracture ) .", "sentence_id": 13}
+{"abstract_id": "25981812", "label": "results", "text": "No patients given SABR had grade @ events or treatment-related death .", "sentence_id": 14}
+{"abstract_id": "25981812", "label": "results", "text": "In the surgery group , one ( @ % ) patient died of surgical complications and @ ( @ % ) patients had grade @-@ treatment-related adverse events .", "sentence_id": 15}
+{"abstract_id": "25981812", "label": "results", "text": "Grade @ events occurring in more than one patient in the surgery group were dyspnoea ( four -LSB- @ % -RSB- patients ) , chest pain ( four -LSB- @ % -RSB- patients ) , and lung infections ( two -LSB- @ % -RSB- ) .", "sentence_id": 16}
+{"abstract_id": "25981812", "label": "conclusions", "text": "SABR could be an option for treating operable stage I NSCLC .", "sentence_id": 17}
+{"abstract_id": "25981812", "label": "conclusions", "text": "Because of the small patient sample size and short follow-up , additional randomised studies comparing SABR with surgery in operable patients are warranted .", "sentence_id": 18}
+{"abstract_id": "25335963", "label": "background", "text": "Major depression is a serious mental disorder that causes substantial distress and impairment in individuals and places an enormous burden on society .", "sentence_id": 0}
+{"abstract_id": "25335963", "label": "background", "text": "Although antidepressant treatment is the most common therapy provided in routine practice , there is little evidence to guide second-line therapy for patients who have failed to respond to antidepressants .", "sentence_id": 1}
+{"abstract_id": "25335963", "label": "background", "text": "The aim of this paper is to describe the study protocol for a randomised controlled trial that measures the clinical effectiveness of cognitive behavioural therapy ( CBT ) as an augmentation strategy to treat patients with non-psychotic major depression identified as suboptimal responders to usual depression care .", "sentence_id": 2}
+{"abstract_id": "25335963", "label": "methods", "text": "The current study is a @-week assessor-blinded randomised , parallel-groups superiority trial with @-month follow-up at an outpatient clinic as part of usual depression care .", "sentence_id": 3}
+{"abstract_id": "25335963", "label": "methods", "text": "Patients aged @-@years with Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition ( DSM-IV ) Major Depressive Disorder who have experienced at least one failed trial of antidepressants as part of usual depression care , will be randomly assigned to receive CBT plus treatment as usual , or treatment as usual alone .", "sentence_id": 4}
+{"abstract_id": "25335963", "label": "methods", "text": "The primary outcome is the change in clinician-rated @-item GRID-Hamilton Depression Rating Scale ( GRID-HAMD ) score at @weeks , and secondary outcomes include severity and change in scores of subjective depression symptoms , proportion of responders and remitters , safety and quality of life .", "sentence_id": 5}
+{"abstract_id": "25335963", "label": "methods", "text": "The primary population will be the intention-to-treat patients .", "sentence_id": 6}
+{"abstract_id": "25316430", "label": "objective", "text": "The enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs .", "sentence_id": 0}
+{"abstract_id": "25316430", "label": "objective", "text": "The objective of the present study was to evaluate the efficacy of a polyherbal ( test ) formulation on cognitive functions , inflammatory markers and oxidative stress in healthy elderly as well as senile dementia of Alzheimer 's type ( SDAT ) patients .", "sentence_id": 1}
+{"abstract_id": "25316430", "label": "methods", "text": "A randomized double-blind placebo - and active-controlled clinical trial was performed in healthy elderly subjects and SDAT patients with an age range of @-@ years .", "sentence_id": 2}
+{"abstract_id": "25316430", "label": "methods", "text": "The polyherbal test formulation along with a placebo was given to healthy elderly subjects while the SDAT patients received either the test formulation containing extracts of Bacopa monnieri ( whole plant ) , Hippophae rhamnoides ( leaves and fruits ) and Dioscorea bulbifera ( bulbils ) at a dose of @ mg or donepezil drug ( Aricept ) at a dose of @ mg , twice daily , for a period of @ months .", "sentence_id": 3}
+{"abstract_id": "25316430", "label": "methods", "text": "After every three months , cognitive functions were assessed by determining the mini mental state examination ( MMSE ) score , digital symbol substitution ( DSS ; subtest of the Wechsler Adult Intelligence Scale-Revised ) , immediate and delayed word recall ( digital memory apparatus-Medicaid systems , Chandigarh , India ) , attention span ( Attention Span Apparatus-Medicaid systems , Chandigarh , India ) , functional activity questionnaire ( FAQ ) and depression ( geriatric depression scale ) scores .", "sentence_id": 4}
+{"abstract_id": "25316430", "label": "methods", "text": "Further inflammatory markers and level of oxidative stress were analyzed using standard biochemical tests .", "sentence_id": 5}
+{"abstract_id": "25316430", "label": "results", "text": "The trial was performed in @ healthy subjects and @ SDAT patients of whom @ healthy subjects and @ SDAT patients completed the study .", "sentence_id": 6}
+{"abstract_id": "25316430", "label": "results", "text": "Administration of the test formulation for a period of @ months was effective in improving cognitive functions in the SDAT patients , when compared to the donepezil-treated group , as determined by the DSS ( @ @ vs @ @ , P = @ ) , word recall immediate ( @ @ vs @ @ , P < @ ) and attention span ( @ @ vs @ @ , P = @ ) scores .", "sentence_id": 7}
+{"abstract_id": "25316430", "label": "results", "text": "A significant improvement in the FAQ ( @ @ vs @ @ , P < @ ) and depression ( @ @ vs @ @ , P < @ ) scores was also observed , whereas no significant differences were observed in the MMSE and word recall delayed scores .", "sentence_id": 8}
+{"abstract_id": "25316430", "label": "results", "text": "The level of inflammation and oxidative stress was markedly reduced in the SDAT patients treated with the test formulation when compared to the donepezil-treated group indicating a likely mechanism of action of the test formulation ( homocysteine @ @ vs @ @ nmol/L , P < @ ; C-reactive protein -LSB- CRP -RSB- @ @ vs @ @ mg/L , P < @ ; tumour necrosis factor alpha -LSB- TNF - -RSB- @ @ vs @ @ pg/ml , P < @ ; superoxide dismutase -LSB- SOD -RSB- @ @ vs @ @ U/g Hb , P = @ ; glutathione peroxidase -LSB- GPx -RSB- @ @ vs @ @ U/g Hb , P < @ ; glutathione -LSB- GSH -RSB- @ @ vs @ @ U/g Hb , P < @ ; thiobarbituric acid reactive substances -LSB- TBARS -RSB- @ @ vs @ @ nmol/g Hb , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25316430", "label": "results", "text": "Similarly , when healthy elderly subjects treated with the test formulation for @ months were compared to the placebo group , a significant ( P < @ ) improvement in cognitive measures ( MMSE , DSS , word recall delayed but not immediate , attention span , FAQ and depression scores ) and a reduction in inflammation ( reduction in homocysteine , CRP , IL-@ and TNF - levels ) and oxidative stress levels ( reduction in SOD , GPx and TBARS and increase in GSH ) was observed .", "sentence_id": 10}
+{"abstract_id": "25316430", "label": "results", "text": "This indicated a protective effect of the test formulation in managing cognitive decline associated with the ageing process .", "sentence_id": 11}
+{"abstract_id": "25316430", "label": "conclusions", "text": "The results of this study demonstrate the therapeutic potential of this novel polyherbal formulation for the management and treatment of SDAT .", "sentence_id": 12}
+{"abstract_id": "24639421", "label": "objective", "text": "To determine the costs and cost-effectiveness of an early childhood home visiting program delivered to families in socio-economically disadvantaged areas of Sydney , Australia during @-@ .", "sentence_id": 0}
+{"abstract_id": "24639421", "label": "methods", "text": "Economic evaluation of a randomized controlled trial , the healthy beginnings ( HB ) trial , from the perspective of the health funder .", "sentence_id": 1}
+{"abstract_id": "24639421", "label": "methods", "text": "Intervention resources were determined from local health district records in @ $ AUD .", "sentence_id": 2}
+{"abstract_id": "24639421", "label": "methods", "text": "Health-care resource utilization was determined through patient-level data linkage .", "sentence_id": 3}
+{"abstract_id": "24639421", "label": "results", "text": "The cost of HB intervention in the clinical trial over @ years was $ @ per child ( @ $ AUD ) .", "sentence_id": 4}
+{"abstract_id": "24639421", "label": "results", "text": "The incremental cost-effectiveness ratio was $ @ per unit BMI avoided and $ @ per @ reduction in BMI z-score .", "sentence_id": 5}
+{"abstract_id": "24639421", "label": "results", "text": "It was estimated that the program could be delivered in practice for $ @ per child ; with incremental cost-effectiveness ratios of $ @ per unit BMI avoided and $ @ per @ reduction in BMI z-score .", "sentence_id": 6}
+{"abstract_id": "24639421", "label": "conclusions", "text": "We present the first economic evaluation of an effective obesity prevention initiative in early childhood .", "sentence_id": 7}
+{"abstract_id": "24639421", "label": "conclusions", "text": "HB is a moderately priced intervention with demonstrated effectiveness that offers similar or better value for money than existing obesity prevention or treatment interventions targeted at older children .", "sentence_id": 8}
+{"abstract_id": "25574111", "label": "objective", "text": "To compare the Helicobacter pylori ( H. pylori ) eradication rate of clarithromycin-based triple therapy , metronidazole-based triple therapy , sequential therapy and concomitant therapy .", "sentence_id": 0}
+{"abstract_id": "25574111", "label": "methods", "text": "A total of @ patients infected with H. pylori were divided into @ groups and each group was treated with a different eradication therapy .", "sentence_id": 1}
+{"abstract_id": "25574111", "label": "methods", "text": "Clarithromycin-based triple therapy was applied to the first group -LSB- rabeprazole , amoxicillin and clarithromycin ( PAC ) group : proton pump inhibitor ( PPI ) , amoxicillin , clarithromycin -RSB- , whereas the second group was treated with metronidazole-based triple therapy -LSB- rabeprazole , amoxicillin and metronidazole ( PAM ) group : PPI , amoxicillin , metronidazole -RSB- .", "sentence_id": 2}
+{"abstract_id": "25574111", "label": "methods", "text": "The third group was treated with rabeprazole and amoxicillin , followed by rabeprazole , clarithromycin and metronidazole ( sequential group ) .", "sentence_id": 3}
+{"abstract_id": "25574111", "label": "methods", "text": "The final group was simultaneously treated with rabeprazole , amoxicillin clarithromycin and metronidazole ( concomitant therapy group ) .", "sentence_id": 4}
+{"abstract_id": "25574111", "label": "methods", "text": "In the case of a failure to eradicate H. pylori , second-line quadruple and third-line eradication therapies were administered .", "sentence_id": 5}
+{"abstract_id": "25574111", "label": "results", "text": "The per protocol ( PP ) analysis was performed on @ , @ , @ and @ patients in the PAC , PAM , sequential and concomitant groups , respectively .", "sentence_id": 6}
+{"abstract_id": "25574111", "label": "results", "text": "We excluded patients who did not receive a C ( @ ) - urea breath test ( @ , @ , @ and @ patients , respectively ) and patients with less than an @ % compliance level ( @ , @ , @ and @ patients , respectively ) .", "sentence_id": 7}
+{"abstract_id": "25574111", "label": "results", "text": "The eradication rates were @ % ( @/@ ) in the PAC group , @ % ( @/@ ) in the PAM group , @ % ( @/@ ) in the sequential group and @ % ( @/@ ) in the concomitant group ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25574111", "label": "results", "text": "All @ patients who failed second-line therapy were treated with third-line eradication therapy .", "sentence_id": 9}
+{"abstract_id": "25574111", "label": "results", "text": "Among these @ patients , @ infections were successfully eradicated with the third-line therapy .", "sentence_id": 10}
+{"abstract_id": "25574111", "label": "results", "text": "Both PP and intention-to-treat analysis showed an eradication rate of @ % ( @/@ ) .", "sentence_id": 11}
+{"abstract_id": "25574111", "label": "results", "text": "In the PAC group , @ of @ patients were successfully cured ( @/@ , @ % ) ; @ of @ patients in the PAM group ( @/@ , @ % ) and @ of @ patients in the sequential group ( @/@ , @ % ) were also cured .", "sentence_id": 12}
+{"abstract_id": "25574111", "label": "results", "text": "In the concomitant group , all @ patients failed ( @/@ , @ % ) .", "sentence_id": 13}
+{"abstract_id": "25574111", "label": "conclusions", "text": "The eradication rate for the concomitant therapy was much higher than those of the standard triple therapy or sequential therapy ( ClinicalTrials.gov number NCT@ ) .", "sentence_id": 14}
+{"abstract_id": "24933332", "label": "background", "text": "Ramucirumab is a human IgG@ monoclonal antibody that targets the extracellular domain of VEGFR-@ .", "sentence_id": 0}
+{"abstract_id": "24933332", "label": "background", "text": "We aimed to assess efficacy and safety of treatment with docetaxel plus ramucirumab or placebo as second-line treatment for patients with stage IV non-small-cell-lung cancer ( NSCLC ) after platinum-based therapy .", "sentence_id": 1}
+{"abstract_id": "24933332", "label": "methods", "text": "In this multicentre , double-blind , randomised phase @ trial ( REVEL ) , we enrolled patients with squamous or non-squamous NSCLC who had progressed during or after a first-line platinum-based chemotherapy regimen .", "sentence_id": 2}
+{"abstract_id": "24933332", "label": "methods", "text": "Patients were randomly allocated ( @:@ ) with a centralised , interactive voice-response system ( stratified by sex , region , performance status , and previous maintenance therapy -LSB- yes vs no -RSB- ) to receive docetaxel @ mg/m ( @ ) and either ramucirumab ( @ mg/kg ) or placebo on day @ of a @ day cycle until disease progression , unacceptable toxicity , withdrawal , or death .", "sentence_id": 3}
+{"abstract_id": "24933332", "label": "methods", "text": "The primary endpoint was overall survival in all patients allocated to treatment .", "sentence_id": 4}
+{"abstract_id": "24933332", "label": "methods", "text": "We assessed adverse events according to treatment received .", "sentence_id": 5}
+{"abstract_id": "24933332", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "24933332", "label": "results", "text": "Between Dec @ , @ , and Jan @ , @ , we screened @ patients , of whom @ patients were randomly allocated to treatment .", "sentence_id": 7}
+{"abstract_id": "24933332", "label": "results", "text": "Median overall survival was @ months ( IQR @-@ ) for @ patients allocated ramucirumab plus docetaxel and @ months ( @-@ ) for @ patients who received placebo plus docetaxel ( hazard ratio @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24933332", "label": "results", "text": "Median progression-free survival was @ months ( IQR @-@ ) for the ramucirumab group compared with @ months ( @-@ ) for the control group ( @ , @-@ ; p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24933332", "label": "results", "text": "We noted treatment-emergent adverse events in @ ( @ % ) of @ patients in the ramucirumab safety population and @ ( @ % ) of @ patients in the control safety population .", "sentence_id": 10}
+{"abstract_id": "24933332", "label": "results", "text": "The most common grade @ or worse adverse events were neutropenia ( @ patients -LSB- @ % -RSB- in the ramucirumab group vs @ -LSB- @ % -RSB- in the control group ) , febrile neutropenia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , leucopenia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and hypertension ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "24933332", "label": "results", "text": "The numbers of deaths from adverse events ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) and grade @ or worse pulmonary haemorrhage ( eight -LSB- @ % -RSB- vs eight -LSB- @ % -RSB- ) did not differ between groups .", "sentence_id": 12}
+{"abstract_id": "24933332", "label": "results", "text": "Toxicities were manageable with appropriate dose reductions and supportive care .", "sentence_id": 13}
+{"abstract_id": "24933332", "label": "conclusions", "text": "Ramucirumab plus docetaxel improves survival as second-line treatment of patients with stage IV NSCLC .", "sentence_id": 14}
+{"abstract_id": "25158273", "label": "objective", "text": "We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis , and determined predictive factors for treatment success .", "sentence_id": 0}
+{"abstract_id": "25158273", "label": "methods", "text": "A total of @ children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for @ months .", "sentence_id": 1}
+{"abstract_id": "25158273", "label": "methods", "text": "Treatment compliance and response were reviewed monthly in each patient using a @-day bed-wetting diary .", "sentence_id": 2}
+{"abstract_id": "25158273", "label": "methods", "text": "Outcomes were assessed according to International Children 's Continence Society criteria , and success rates at @ and @ months were compared for desmopressin and enuretic alarm .", "sentence_id": 3}
+{"abstract_id": "25158273", "label": "methods", "text": "Additional intention to treat analyses were performed , considering cases with missing data as failures .", "sentence_id": 4}
+{"abstract_id": "25158273", "label": "methods", "text": "Possible demographic factors predicting success were investigated by logistic regression analysis .", "sentence_id": 5}
+{"abstract_id": "25158273", "label": "results", "text": "Overall @ children ( @ % ) in the desmopressin group and @ ( @ % ) in the enuretic alarm group withdrew after randomization .", "sentence_id": 6}
+{"abstract_id": "25158273", "label": "results", "text": "Based on patients who completed @ months of treatment , success ( more than @ % reduction in wet nights per month ) was achieved in @ % and @ % of children in the desmopressin and enuretic alarm groups , respectively .", "sentence_id": 7}
+{"abstract_id": "25158273", "label": "results", "text": "At @ months @ % of those receiving desmopressin and @ % of those treated with enuretic alarm had success .", "sentence_id": 8}
+{"abstract_id": "25158273", "label": "results", "text": "However , long-term success rate was significantly higher with desmopressin ( @ % vs @ % ) if intention to treat population was considered .", "sentence_id": 9}
+{"abstract_id": "25158273", "label": "results", "text": "Multivariate analysis revealed treatment group , severity of enuresis and monthly income as independent predictors of cure at @ months .", "sentence_id": 10}
+{"abstract_id": "25158273", "label": "conclusions", "text": "In compliant patients desmopressin lyophilisate and enuretic alarm provided equivalent success at the end of treatment and after extended followup .", "sentence_id": 11}
+{"abstract_id": "25158273", "label": "conclusions", "text": "Alarm therapy had a high rate of early withdrawal from therapy and consequently lower rates of success on intention to treat analyses .", "sentence_id": 12}
+{"abstract_id": "25158273", "label": "conclusions", "text": "Severe enuresis ( more than @ wet nights weekly ) is an important predictive factor for cure after first-line treatment .", "sentence_id": 13}
+{"abstract_id": "24675386", "label": "objective", "text": "Following from previous research in which post-encoding suggestions of threat led to the development of a memory bias ( in the presumed absence of an attentional bias ; Senn & Radomsky , @ ) , we sought to examine whether the development of a similar threat-relevant memory bias could be fostered via a purely informational pathway .", "sentence_id": 0}
+{"abstract_id": "24675386", "label": "methods", "text": "A vignette about a classroom interaction was read aloud to ( n = @ ) undergraduate participants who then completed a post-encoding recall test .", "sentence_id": 1}
+{"abstract_id": "24675386", "label": "methods", "text": "Participants were told that the experimenter forgot to read the last sentence of the vignette , and were then randomly assigned either to the Threat condition , in which the additional statement indicated that a character in the vignette had a highly contagious flu , or to the No-Threat condition , in which the additional statement indicated that a character in the vignette had been accepted to graduate school .", "sentence_id": 2}
+{"abstract_id": "24675386", "label": "methods", "text": "A second recall test was then administered .", "sentence_id": 3}
+{"abstract_id": "24675386", "label": "results", "text": "Participants in the Threat condition ( but not those in the No-Threat condition ) demonstrated aproportionate memory bias in favor of threatening information .", "sentence_id": 4}
+{"abstract_id": "24675386", "label": "results", "text": "This bias was not evident at the initial recall test .", "sentence_id": 5}
+{"abstract_id": "24675386", "label": "conclusions", "text": "Time spent engaging in active recall was not assessed .", "sentence_id": 6}
+{"abstract_id": "24675386", "label": "conclusions", "text": "Also , although the study was designed to minimize demand characteristics , it is possible that these played a role .", "sentence_id": 7}
+{"abstract_id": "24675386", "label": "conclusions", "text": "An explicit memory bias for threat can be created through informational means alone , even when no threat was present at encoding .", "sentence_id": 8}
+{"abstract_id": "24675386", "label": "conclusions", "text": "Results are discussed in terms of pathways to fear and of cognitive approaches to understanding and treating anxiety disorders .", "sentence_id": 9}
+{"abstract_id": "24471325", "label": "objective", "text": "To evaluate the multi-function rapid allergic skin test instrument for application in drug allergy testing .", "sentence_id": 0}
+{"abstract_id": "24471325", "label": "methods", "text": "Three hundred patients were planned to be treated with cephalosporins Injection were divided randomly into @ groups , the new allergic skin test instrument group , normal allergic skin test instrument group , and traditional skin test group , the true positive rate and false positive rate were calculated .", "sentence_id": 1}
+{"abstract_id": "24471325", "label": "methods", "text": "Using multifunctional rapid allergy skin test was carried out on @ cases of volunteers preliminary clinical evaluation of traditional Chinese medicine injections skin test .", "sentence_id": 2}
+{"abstract_id": "24471325", "label": "results", "text": "There were no significance difference between the new allergic skin test instrument group and control group in the true positive rate .", "sentence_id": 3}
+{"abstract_id": "24471325", "label": "results", "text": "As compared with the control group , a significance difference was found between the new allergic skin test instrument group and control group in false positive rate respectively ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24471325", "label": "conclusions", "text": "The multi-function rapid allergic skin test instrument is safe and easy to use , with a higher rate of accuracy and lower false positive rate .", "sentence_id": 5}
+{"abstract_id": "25659256", "label": "background", "text": "Current medical knowledge has provided us with a wide range of possibilities of treating chronic wounds .", "sentence_id": 0}
+{"abstract_id": "25659256", "label": "background", "text": "Over the recent decades , in particular , significant progress has been made in this field .", "sentence_id": 1}
+{"abstract_id": "25659256", "label": "background", "text": "The authors present an overview of current knowledge of chronic wound healing , pointing out the surgeons role in the process of chronic wound management .", "sentence_id": 2}
+{"abstract_id": "25659256", "label": "background", "text": "Using surgical therapy , we are able to heal a chronic wound in a shorter period of time , particularly if the treatment is accelerated by the application of platelet-rich plasma ( PRP ) as a source of growth factors .", "sentence_id": 3}
+{"abstract_id": "25659256", "label": "methods", "text": "The pilot randomized prospective study included four patients with chronic wounds of the lower leg after previous failure of conservative therapy who were indicated for skin transplantation .", "sentence_id": 4}
+{"abstract_id": "25659256", "label": "methods", "text": "Following previous vacuum-assisted closure therapy , the patients undergoing skin transplantation were prospectively randomized into two groups .", "sentence_id": 5}
+{"abstract_id": "25659256", "label": "methods", "text": "Autologous PRP was used in one of the groups and standard skin transplantation without PRP was performed in the other one .", "sentence_id": 6}
+{"abstract_id": "25659256", "label": "results", "text": "In the PRP group , @ % of the wound areas were healed on the @th day after the operation .", "sentence_id": 7}
+{"abstract_id": "25659256", "label": "results", "text": "In the other group , @ % of the areas were healed on the @th day following the operation .", "sentence_id": 8}
+{"abstract_id": "25659256", "label": "results", "text": "In the PRP group , complete healing of the defect occurred in both patients at @ and @ days post-surgery .", "sentence_id": 9}
+{"abstract_id": "25659256", "label": "results", "text": "In the second group , one patient completely healed within @ days ; the other one was not fully healed even at @ months post-surgery .", "sentence_id": 10}
+{"abstract_id": "25659256", "label": "conclusions", "text": "Most patient groups at great risk may benefit from the method using PRP , as well as patients with chronic wounds who have failed conventional methods available for both general and local therapy .", "sentence_id": 11}
+{"abstract_id": "25659256", "label": "conclusions", "text": "This fact has been confirmed by the authors initial experience presented.Key words : platelet-rich plasma ( PRP ) - platelets wound healing chronic wound .", "sentence_id": 12}
+{"abstract_id": "24248549", "label": "objective", "text": "To compare lag-screw sliding characteristics and fixation stability of two cephalomedullary nails ( CMN ) with different lag-screw designs ( solid and telescopic ) , we conducted a biomechanical study and an analysis of clinical results .", "sentence_id": 0}
+{"abstract_id": "24248549", "label": "methods", "text": "Six pairs of cadaver femurs with simulated intertrochanteric fractures were randomly assigned to one of two CMN fixations .", "sentence_id": 1}
+{"abstract_id": "24248549", "label": "methods", "text": "Femur constructs were statically then cyclically loaded on an MTS machine .", "sentence_id": 2}
+{"abstract_id": "24248549", "label": "methods", "text": "Lag-screw sliding and inferior and lateral femoral head displacements were measured , following which failure strength of the construct was determined .", "sentence_id": 3}
+{"abstract_id": "24248549", "label": "methods", "text": "Forty-five patients with intertrochanteric fractures treated with these CMN were identified .", "sentence_id": 4}
+{"abstract_id": "24248549", "label": "methods", "text": "Medical records and radiographs were reviewed and analyzed using Fisher 's exact test and Student 's t test to determine lag-screw sliding .", "sentence_id": 5}
+{"abstract_id": "24248549", "label": "results", "text": "No difference was seen with cycling in inferior femoral head displacement between the two screw designs .", "sentence_id": 6}
+{"abstract_id": "24248549", "label": "results", "text": "The solid screw had an average inferior head displacement of @ mm compared with @ mm for the telescoping screw ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24248549", "label": "results", "text": "The solid lag screws slid an average of @ mm lateral from the nail , whereas the telescoping screws slid an average of @ mm ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24248549", "label": "results", "text": "In our clinical review , the average lateral sliding of the telescoping screw was @ mm and of the solid screw was @ mm ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24248549", "label": "results", "text": "Despite differences in lateral sliding , there were no reoperations for prominent or painful hardware in either group .", "sentence_id": 10}
+{"abstract_id": "24248549", "label": "conclusions", "text": "Both designs are acceptable devices for stabilization of intertrochanteric fractures .", "sentence_id": 11}
+{"abstract_id": "24248549", "label": "conclusions", "text": "Clinical and biomechanical data demonstrate greater lateral sliding in the solid lag-screw group , making for greater potential for lateral-sided hip pain in CMNs with solid lag screws as opposed to telescoping lag screws .", "sentence_id": 12}
+{"abstract_id": "24793722", "label": "objective", "text": "Neonatal diagnoses are often used as surrogate endpoints for longer-term outcomes .", "sentence_id": 0}
+{"abstract_id": "24793722", "label": "objective", "text": "We sought to characterize the correlation between neonatal diagnoses and early childhood neurodevelopment .", "sentence_id": 1}
+{"abstract_id": "24793722", "label": "methods", "text": "We conducted secondary analysis of a multicenter randomized controlled trial of antenatal magnesium sulfate vs placebo administered to women at imminent risk for delivery < @ weeks to prevent death and cerebral palsy in their offspring .", "sentence_id": 2}
+{"abstract_id": "24793722", "label": "methods", "text": "Singletons and twins delivering @-@ @ weeks who survived to hospital discharge and had @-year-old outcome data were included .", "sentence_id": 3}
+{"abstract_id": "24793722", "label": "methods", "text": "Those surviving to age @ years were assessed by trained physicians and the Bayley II Scales of Infant Development Mental Development and Psychomotor Development Indices .", "sentence_id": 4}
+{"abstract_id": "24793722", "label": "methods", "text": "Neonatal diagnoses at the time of each baby 's initial hospital discharge were examined singly and in combination to determine those most predictive of childhood neurodevelopmental impairment , defined as a childhood diagnosis of moderate/severe cerebral palsy and/or Bayley scores > @ SD below the mean .", "sentence_id": 5}
+{"abstract_id": "24793722", "label": "methods", "text": "Data were analyzed by multiple regression models and area under receiver operating characteristic curves .", "sentence_id": 6}
+{"abstract_id": "24793722", "label": "results", "text": "A total of @ children met criteria .", "sentence_id": 7}
+{"abstract_id": "24793722", "label": "results", "text": "Children were delivered at a mean of @ weeks ' gestation .", "sentence_id": 8}
+{"abstract_id": "24793722", "label": "results", "text": "In all , @ ( @ % ) had neurodevelopmental impairment .", "sentence_id": 9}
+{"abstract_id": "24793722", "label": "results", "text": "In models controlling for gestational age at delivery , maternal education , maternal race , tobacco/alcohol/drug use during pregnancy , randomization to magnesium , fetal sex , and chorioamnionitis , individual neonatal morbidities were moderately predictive of childhood neurodevelopmental impairment ( best model area under receiver operating characteristic curve , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24793722", "label": "results", "text": "Combinations of @ , @ , and @ morbidities did not improve the prediction of neurodevelopmental impairment .", "sentence_id": 11}
+{"abstract_id": "24793722", "label": "conclusions", "text": "Approximately @ in @ previously preterm children had neurodevelopmental impairment at age @ years .", "sentence_id": 12}
+{"abstract_id": "24793722", "label": "conclusions", "text": "Prediction of childhood outcomes from neonatal diagnoses remains imperfect .", "sentence_id": 13}
+{"abstract_id": "24313916", "label": "objective", "text": "This @-week , multicenter , double-blind , randomized , placebo-controlled study ( NCT@ ) compared efficacy and safety of certolizumab pegol ( CZP ) in combination with methotrexate ( MTX ) vs placebo plus MTX in Japanese rheumatoid arthritis ( RA ) patients with inadequate response to MTX .", "sentence_id": 0}
+{"abstract_id": "24313916", "label": "methods", "text": "In total , @ patients were randomized @:@:@:@ to subcutaneous CZP @ , @ , or @ mg ( induction dose : @ mg or @ mg CZP at Weeks @ , @ , and @ ) plus MTX or placebo plus MTX every @ weeks .", "sentence_id": 1}
+{"abstract_id": "24313916", "label": "methods", "text": "Primary endpoint was ACR@ response at Week @ .", "sentence_id": 2}
+{"abstract_id": "24313916", "label": "results", "text": "ACR@ response rates were @ % , @ % , @ % , and @ % at Week @ , and @ % , @ % , @ % , and @ % at Week @ for CZP @ , @ , and @ mg , and placebo groups , respectively , with statistical significance between each CZP group and placebo .", "sentence_id": 3}
+{"abstract_id": "24313916", "label": "results", "text": "Change in Total Sharp Score over @ weeks was significantly smaller in CZP @ and @ mg groups vs placebo .", "sentence_id": 4}
+{"abstract_id": "24313916", "label": "results", "text": "Improvements in health-related quality of life ( HRQoL ) were observed in all three CZP groups vs placebo .", "sentence_id": 5}
+{"abstract_id": "24313916", "label": "results", "text": "Incidence of adverse events was similar between CZP groups .", "sentence_id": 6}
+{"abstract_id": "24313916", "label": "conclusions", "text": "CZP plus MTX resulted in rapid , sustained reductions in RA signs and symptoms in Japanese patients with inadequate response to MTX , with significant inhibition of radiographic progression and improved HRQoL .", "sentence_id": 7}
+{"abstract_id": "24329506", "label": "background", "text": "Growth hormone deficiency ( GHD ) is associated with reduced bone mineral content and increased risk of osteoporotic fractures .", "sentence_id": 0}
+{"abstract_id": "24329506", "label": "background", "text": "Reduced peak bone mass might explain the low bone mineral density ( BMD ) among patients with childhood onset GHD ( CO-GHD ) whilst the cause of osteopenia in adult-onset GHD ( AO-GHD ) is not fully understood .", "sentence_id": 1}
+{"abstract_id": "24329506", "label": "objective", "text": "Prospective multicentric study to asses bone status in GHD adults after two years of recombinant growth hormone replacement treatment .", "sentence_id": 2}
+{"abstract_id": "24329506", "label": "methods", "text": "In @ GHD adults ( @ men ; @ yrs ) we have measured BMD and bone markers ( CTX , osteocalcin ) during two years of rhGH treatment ( at baseline , after @ and @ months , and after @ and @ years ) .", "sentence_id": 3}
+{"abstract_id": "24329506", "label": "methods", "text": "Patients were adequately substituted for GHD and other pituitary deficiencies .", "sentence_id": 4}
+{"abstract_id": "24329506", "label": "results", "text": "We have observed an increase in BMD-lumbar spine : n = @ , @ @ g/cm@ , p < @ ; femoral neck n = @ ; @ @ ; p = @ ; BMD-whole body @ @ ; p = @ .", "sentence_id": 5}
+{"abstract_id": "24329506", "label": "results", "text": "We have compared gender difference : BMD-L-spine by @ % in men ( n = @ ) and by @ % in women ( n = @ ) ( p = @ ) ; BMD-femoral neck increased by @ % in men and by about @ % in women ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24329506", "label": "results", "text": "In women , the initial decrease in BMD was recorded after @ months .", "sentence_id": 7}
+{"abstract_id": "24329506", "label": "results", "text": "CO-GHD adults yielded a higher increase in BMD - L-spine ( @ % , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24329506", "label": "results", "text": "A correlation exists between IGF-I levels and BMD in lumbar spine ( @st year : R = @ , p = @ ; @nd year : R = @ , p = @ ) and between IGF-I and osteocalcin ( @st year : R = @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24329506", "label": "conclusions", "text": "Two-year therapy with recombinant human growth hormone improved bone status .", "sentence_id": 10}
+{"abstract_id": "24329506", "label": "conclusions", "text": "IGF-I appears to be a good indicator of rhGH effect on bone ( Tab .", "sentence_id": 11}
+{"abstract_id": "24329506", "label": "conclusions", "text": "@ , Fig. @ , Ref .", "sentence_id": 12}
+{"abstract_id": "24329506", "label": "conclusions", "text": "@ ) .", "sentence_id": 13}
+{"abstract_id": "24329506", "label": "conclusions", "text": "Text in PDF www.elis.sk .", "sentence_id": 14}
+{"abstract_id": "25157964", "label": "objective", "text": "Up to @ % of patients with treatment-resistant schizophrenia do not respond to clozapine .", "sentence_id": 0}
+{"abstract_id": "25157964", "label": "objective", "text": "Pharmacological augmentation to clozapine has been studied with unimpressive results .", "sentence_id": 1}
+{"abstract_id": "25157964", "label": "objective", "text": "The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia .", "sentence_id": 2}
+{"abstract_id": "25157964", "label": "methods", "text": "In a randomized single-blind @-week study , patients with clozapine-resistant schizophrenia were assigned to treatment as usual ( clozapine group ) or a course of bilateral ECT plus clozapine ( ECT plus clozapine group ) .", "sentence_id": 3}
+{"abstract_id": "25157964", "label": "methods", "text": "Nonresponders from the clozapine group received an @-week open trial of ECT ( crossover phase ) .", "sentence_id": 4}
+{"abstract_id": "25157964", "label": "methods", "text": "ECT was performed three times per week for the first @ weeks and twice weekly for the last @ weeks .", "sentence_id": 5}
+{"abstract_id": "25157964", "label": "methods", "text": "Clozapine dosages remained constant .", "sentence_id": 6}
+{"abstract_id": "25157964", "label": "methods", "text": "Response was defined as @ % reduction in symptoms based on the psychotic symptom subscale of the Brief Psychiatric Rating Scale , a Clinical Global Impressions ( CGI ) - severity rating < @ , and a CGI-improvement rating @ .", "sentence_id": 7}
+{"abstract_id": "25157964", "label": "results", "text": "The intent-to-treat sample included @ participants ( ECT plus clozapine group , N = @ ; clozapine group , N = @ ) .", "sentence_id": 8}
+{"abstract_id": "25157964", "label": "results", "text": "All @ patients from the clozapine group received ECT in the crossover phase .", "sentence_id": 9}
+{"abstract_id": "25157964", "label": "results", "text": "Fifty percent of the ECT plus clozapine patients met the response criterion .", "sentence_id": 10}
+{"abstract_id": "25157964", "label": "results", "text": "None of the patients in the clozapine group met the criterion .", "sentence_id": 11}
+{"abstract_id": "25157964", "label": "results", "text": "In the crossover phase , response was @ % .", "sentence_id": 12}
+{"abstract_id": "25157964", "label": "results", "text": "There were no discernible differences between groups on global cognition .", "sentence_id": 13}
+{"abstract_id": "25157964", "label": "results", "text": "Two patients required the postponement of an ECT session because of mild confusion .", "sentence_id": 14}
+{"abstract_id": "25157964", "label": "conclusions", "text": "The augmentation of clozapine with ECT is a safe and effective treatment option .", "sentence_id": 15}
+{"abstract_id": "25157964", "label": "conclusions", "text": "Further research is required to determine the persistence of the improvement and the potential need for maintenance treatments .", "sentence_id": 16}
+{"abstract_id": "24851692", "label": "objective", "text": "To evaluate the performance effect of short-term catheter-directed thrombolysis with different dosage of rt-PA allied with endovascular interventional therapy for patients with acute lower limb ischemia .", "sentence_id": 0}
+{"abstract_id": "24851692", "label": "methods", "text": "To separate @ consecutive patients suffered from acute lower limb ischemia into two groups at random , then adopt catheter-directed thrombolysis for each group of patients injected @ mg ( Group A ) or @ mg ( Group B ) rt-PA into the occlusive lesion correspondingly , and subsequently perform endovascular intervention on significant underlying lesions on the base of angiography results .", "sentence_id": 1}
+{"abstract_id": "24851692", "label": "methods", "text": "Adopt statistical methods to assess treatment effectiveness , rates of complication and amputation rates within @ days , @ months or @ months .", "sentence_id": 2}
+{"abstract_id": "24851692", "label": "methods", "text": "The statistic analysis was performed under SPSS @ format , and adopts t test and ( @ ) test .", "sentence_id": 3}
+{"abstract_id": "24851692", "label": "results", "text": "There was no statistical difference on patient characteristics and lesions between both groups ( P > @ ) .", "sentence_id": 4}
+{"abstract_id": "24851692", "label": "results", "text": "Procedural success rates as well clinical success rates were all @ % .", "sentence_id": 5}
+{"abstract_id": "24851692", "label": "results", "text": "Not incur any diversity on thrombolysis effectiveness between both groups injected different dosage of rt-PA ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24851692", "label": "results", "text": "Not found major differences on ratios of PTA or implant stent between both groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24851692", "label": "results", "text": "During the follow-up period of @-day , @ - , @ - months , there were no statistical differences on the amputation-free survival rates and complication rates between both groups .", "sentence_id": 8}
+{"abstract_id": "24851692", "label": "conclusions", "text": "Whereas short-term catheter-directed thrombolysis combined with endovascular interventional therapy won good operation effectiveness on patients with acute lower limb ischemia , moreover the dosage of rt-PA did not impact on thrombolysis , it is worthy to be applied in the clinical practice .", "sentence_id": 9}
+{"abstract_id": "24285581", "label": "objective", "text": "The Prevencin con Dieta Mediterrnea ( PREDIMED ) trial showed that a Mediterranean diet ( MedDiet ) supplemented with either extra virgin olive oil or @ g/d of mixed nuts reduced incident cardiovascular events compared with a control ( low fat ) diet .", "sentence_id": 0}
+{"abstract_id": "24285581", "label": "objective", "text": "The mechanisms of cardiovascular protection afforded by MedDiets remain to be uncovered .", "sentence_id": 1}
+{"abstract_id": "24285581", "label": "objective", "text": "We assessed the effect of both supplemented MedDiets on internal carotid intima-media thickness ( ICA-IMT ) and plaque height , the ultrasound features that best predict future cardiovascular events , in subjects at high cardiovascular risk .", "sentence_id": 2}
+{"abstract_id": "24285581", "label": "results", "text": "In a PREDIMED subcohort ( n = @ ) , plaque height and carotid IMT of @ prespecified segments ( ICA , bifurcation , and common ) were sonographically assessed at baseline and after intervention for a mean of @ years .", "sentence_id": 3}
+{"abstract_id": "24285581", "label": "results", "text": "We evaluated @ subjects with complete data .", "sentence_id": 4}
+{"abstract_id": "24285581", "label": "results", "text": "In a multivariate model , mean ICA-IMT progressed in the control diet group ( mean -LSB- @ % confidence interval -RSB- , @ mm -LSB- -@ to @ mm -RSB- ) , whereas it regressed in the MedDiet + nuts group ( -@ mm -LSB- -@ to -@ mm -RSB- ; P = @ versus control ) .", "sentence_id": 5}
+{"abstract_id": "24285581", "label": "results", "text": "Similar results were observed for maximum ICA-IMT ( control , @ mm -LSB- @ to @ mm -RSB- ; MedDiet + nuts , -@ mm -LSB- -@ to @ mm -RSB- ; P = @ ) and maximum plaque height ( control , @ mm -LSB- @ to @ mm -RSB- ; MedDiet + nuts , -@ mm -LSB- -@ to @ mm -RSB- ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24285581", "label": "results", "text": "There were no changes in ICA-IMT or plaque after the MedDiet + extra virgin olive oil .", "sentence_id": 7}
+{"abstract_id": "24285581", "label": "conclusions", "text": "Compared with a control diet , consumption of a MedDiet supplemented with nuts is associated with delayed progression of ICA-IMT and plaque .", "sentence_id": 8}
+{"abstract_id": "24285581", "label": "conclusions", "text": "The results contribute mechanistic evidence for the reduction of cardiovascular events observed in the PREDIMED trial .", "sentence_id": 9}
+{"abstract_id": "24639432", "label": "background", "text": "This study assessed the efficacy and safety of the once-daily glucagon-like peptide-@ receptor agonist , lixisenatide , in Asian patients with type @ diabetes mellitus inadequately controlled on metforminsulfonylurea .", "sentence_id": 0}
+{"abstract_id": "24639432", "label": "methods", "text": "In this @-week , double-blind , placebo-controlled , multinational study , patients were randomized to lixisenatide @ g once daily or placebo .", "sentence_id": 1}
+{"abstract_id": "24639432", "label": "methods", "text": "The primary endpoint was absolute change in glycated haemoglobin ( HbA@c ) from baseline to week @ .", "sentence_id": 2}
+{"abstract_id": "24639432", "label": "results", "text": "A total of @ patients were randomized .", "sentence_id": 3}
+{"abstract_id": "24639432", "label": "results", "text": "Lixisenatide significantly reduced HbA@c levels compared with placebo ( LS mean difference : -@ % , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24639432", "label": "results", "text": "A significantly higher proportion of lixisenatide-treated patients achieved HbA@c targets of < @ % ( p = @ ) and @ % ( p = @ ) versus placebo .", "sentence_id": 5}
+{"abstract_id": "24639432", "label": "results", "text": "Lixisenatide was associated with a statistically significant reduction in @-h postprandial plasma glucose after a standardized breakfast versus placebo ( LS mean difference : -@ mmol/L , p < @ ) and a significant reduction in fasting plasma glucose ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24639432", "label": "results", "text": "There was no difference in weight loss versus placebo , with a modest reduction in body weight reported for both groups ( lixisenatide : -@ kg , placebo : -@ kg ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24639432", "label": "results", "text": "The incidence of treatment-emergent adverse events ( TEAEs ) was @ % with lixisenatide versus @ % with placebo , with serious TEAEs reported in @ % versus @ % of patients , respectively .", "sentence_id": 8}
+{"abstract_id": "24639432", "label": "results", "text": "The most common TEAE in the lixisenatide group was nausea ( @ % vs @ % with placebo ) .", "sentence_id": 9}
+{"abstract_id": "24639432", "label": "results", "text": "The incidence of symptomatic hypoglycaemia was @ % with lixisenatide treatment and @ % with placebo ( p = @ ) , with no severe symptomatic hypoglycaemia events reported .", "sentence_id": 10}
+{"abstract_id": "24639432", "label": "conclusions", "text": "In Asian patients with type @ diabetes mellitus insufficiently controlled on metforminsulfonylurea , lixisenatide significantly improved glycaemic control and was well tolerated during the @-week study .", "sentence_id": 11}
+{"abstract_id": "24837113", "label": "background", "text": "School absenteeism because of infections is one of the most important problems facing both public and private primary schools .", "sentence_id": 0}
+{"abstract_id": "24837113", "label": "background", "text": "The aim of the study was to assess the impact of infections on school absenteeism and their reduction with a handwashing program using hand sanitizer .", "sentence_id": 1}
+{"abstract_id": "24837113", "label": "methods", "text": "The study was an @-month-long , randomized , controlled open study ( N = @,@ children , aged @-@ years old ) at @ state schools in Almeria ( Spain ) .", "sentence_id": 2}
+{"abstract_id": "24837113", "label": "methods", "text": "The experimental group ( EG ) washed their hands with soap and water , complemented with the use of hand sanitizer , and the control group ( CG ) followed the usual handwashing procedure .", "sentence_id": 3}
+{"abstract_id": "24837113", "label": "methods", "text": "The total number of episodes and days missed as well as those because of upper respiratory infections and gastrointestinal infections were compared in both groups with a Z-test .", "sentence_id": 4}
+{"abstract_id": "24837113", "label": "results", "text": "The students were absent @,@ days in @,@ episodes .", "sentence_id": 5}
+{"abstract_id": "24837113", "label": "results", "text": "The incidence of total absent episodes and percent of missed days , including those because of upper respiratory infections and gastrointestinal infections , were significantly lower in the EG than the CG ( P < @ ) , and this was maintained through the flu pandemic period .", "sentence_id": 6}
+{"abstract_id": "24837113", "label": "conclusions", "text": "School absenteeism because of infections in schools is reduced when a hand hygiene program utilizing sanitizing gels is properly carried out , especially during the flu season .", "sentence_id": 7}
+{"abstract_id": "25062129", "label": "objective", "text": "The purpose of the study was to measure contact lens lipid spoliation of silicone hydrogel PureVision ( balafilcon A ) and hydrogel Acuvue @ ( etafilcon A ) contact lenses worn for @ hours single use ( DD ) and @ days of extended wear ( EW ) .", "sentence_id": 0}
+{"abstract_id": "25062129", "label": "methods", "text": "Two similar study populations ( DD , n = @ ; EW , n = @ ) , were enrolled at four study sites .", "sentence_id": 1}
+{"abstract_id": "25062129", "label": "methods", "text": "In each population , a bilateral , randomized , crossover ( lens material ) , subject-masked experimental design was followed .", "sentence_id": 2}
+{"abstract_id": "25062129", "label": "methods", "text": "Worn contact lenses were analyzed for lipid uptake using high-performance liquid chromatography by two laboratories : Alcon Laboratories ( right lens total uptake ) and OTG Research & Consultancy ( left lens total uptake and individual lipid classes ) .", "sentence_id": 3}
+{"abstract_id": "25062129", "label": "results", "text": "Lipid uptake was different for the two materials : total lipid ( p < @ ) , cholesterol esters ( p < @ ) , cholesterol ( p < @ EW only ) , and triglycerides/phospholipids ( p < @ ) were higher for balafilcon A , whereas fatty acid ( p < @ EW only ) was higher for etafilcon A.", "sentence_id": 4}
+{"abstract_id": "25062129", "label": "results", "text": "The ratio of the extracted lipids was also different : higher percentages of triglycerides/phospholipids ( p < @ ) and cholesterol ( p < @ EW only ) for balafilcon A and higher percentages of fatty acids/di - and monoglycerides ( p < @ ) for etafilcon A.", "sentence_id": 5}
+{"abstract_id": "25062129", "label": "conclusions", "text": "Total lipid uptake was highly material dependent .", "sentence_id": 6}
+{"abstract_id": "25062129", "label": "conclusions", "text": "Both laboratories measured a greater uptake of lipids by the silicone hydrogel than the hydrogel material , a difference that was evident after only @ hours of DD .", "sentence_id": 7}
+{"abstract_id": "25062129", "label": "conclusions", "text": "Total lipid uptake was greater after @ days of EW compared with @ hours of DD .", "sentence_id": 8}
+{"abstract_id": "25062129", "label": "conclusions", "text": "Of interest for contact lens spoliation and its avoidance was the differential lipid uptake profile , indicating material selectivity .", "sentence_id": 9}
+{"abstract_id": "25062129", "label": "conclusions", "text": "Whereas greater differentiation between materials was possible after @ days of EW for each material , the lipid uptake profile was similar for DD and EW , indicating a greater material effect than a wear modality effect .", "sentence_id": 10}
+{"abstract_id": "24261345", "label": "background", "text": "This study was done to investigate how nicardipine , remifentanil and dexmedetomidine affect the balance of the autonomic nervous system in patients receiving controlled hypotension under general anaesthesia by evaluating heart rate variability indices .", "sentence_id": 0}
+{"abstract_id": "24261345", "label": "methods", "text": "Sixty-two patients were randomly allocated to either the nicardipine-sevoflurane ( Group N , n = @ ) , remifentanil-sevoflurane ( Group R , n = @ ) or dexmedetomidine-sevoflurane ( Group D , n = @ ) group for controlled hypotension during orthognathic surgery .", "sentence_id": 1}
+{"abstract_id": "24261345", "label": "methods", "text": "Electrocardiogram data acquisition was done after vital sign stabilization following anaesthesia induction ( T@ ) and @min after controlled hypotension was induced ( T@ ) .", "sentence_id": 2}
+{"abstract_id": "24261345", "label": "results", "text": "Total power and low frequency ( LF ) power was significantly decreased at T@ compared with T@ in all groups , while a decrease in high frequency ( HF ) power was only observed in Group N ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24261345", "label": "results", "text": "LF/HF ratios of Group R and D were significantly suppressed at T@ compared with T@ ( P = @ and P < @ , respectively ) , but was increased Group N ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24261345", "label": "results", "text": "The LF/HF ratio of Group N was significantly higher than Group R and D at T@ ( P < @ in both ) , with Group D showing a significantly lower LF/HF ratio compared with Group R ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24261345", "label": "conclusions", "text": "Remifentanil and dexmedetomidine did not have sympathetic nervous system-stimulating effects during controlled hypotension , while remifentanil seemed to be superior in preserving the overall balance in autonomic nervous system activity .", "sentence_id": 6}
+{"abstract_id": "24261345", "label": "conclusions", "text": "Nicardipine was found to stimulate the sympathetic nervous system , which may be problematic in patients vulnerable to disturbances in the autonomic nervous system .", "sentence_id": 7}
+{"abstract_id": "26035185", "label": "background", "text": "Vortioxetine ( Lu AA@ ) is an antidepressant with a mechanism of action thought to be related to a combination of @ pharmacologic actions : direct modulation of several receptors and inhibition of the serotonin transporter .", "sentence_id": 0}
+{"abstract_id": "26035185", "label": "objective", "text": "To evaluate the efficacy of vortioxetine @ and @ mg once daily in outpatients with major depressive disorder .", "sentence_id": 1}
+{"abstract_id": "26035185", "label": "methods", "text": "This @-week , multicenter , randomized , double-blind , placebo-controlled , parallel-group study was conducted from July @ to January @ among adults with a primary diagnosis of recurrent major depressive disorder ( DSM-IV-TR ) .", "sentence_id": 2}
+{"abstract_id": "26035185", "label": "methods", "text": "Eligible subjects were randomized in @:@:@ ratio to @ of @ treatment arms : vortioxetine @ mg , vortioxetine @ mg , or placebo once daily for @ weeks .", "sentence_id": 3}
+{"abstract_id": "26035185", "label": "methods", "text": "Subjects who completed the @-week trial entered a @-week blinded discontinuation period to assess potential discontinuation symptoms .", "sentence_id": 4}
+{"abstract_id": "26035185", "label": "methods", "text": "The primary endpoint was the least squares mean change in Montgomery-Asberg Depression Rating Scale ( MADRS ) total score from baseline .", "sentence_id": 5}
+{"abstract_id": "26035185", "label": "methods", "text": "Key secondary outcomes were analyzed in the following prespecified sequential order : MADRS response ( @ % decrease from baseline in total score ) , Clinical Global Impressions-Improvement score , change from baseline in MADRS total score in subjects with baseline Hamilton Anxiety Rating Scale score @ , MADRS remission ( total score @ ) , and change from baseline in Sheehan Disability Scale total score ( all at week @ ) .", "sentence_id": 6}
+{"abstract_id": "26035185", "label": "results", "text": "A total of @ subjects were randomized to placebo ( n = @ ) , vortioxetine @ mg ( n = @ ) , and vortioxetine @ mg ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "26035185", "label": "results", "text": "Mean ( SE ) reductions from baseline in MADRS total score ( week @ ) were -@ ( @ ) , -@ ( @ ) , and -@ ( @ ) for the placebo , vortioxetine @ mg ( P = @ vs placebo ) , and vortioxetine @ mg ( P = @ vs placebo ) groups .", "sentence_id": 8}
+{"abstract_id": "26035185", "label": "results", "text": "MADRS response/remission was achieved in @ % / @ % , @ % / @ % , and @ % / @ % of subjects , respectively , in the @ groups .", "sentence_id": 9}
+{"abstract_id": "26035185", "label": "results", "text": "Only MADRS response for vortioxetine @ mg significantly separated from placebo ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26035185", "label": "results", "text": "Treatment was well tolerated , with the most frequently reported adverse events consisting of nausea , headache , diarrhea , and dizziness .", "sentence_id": 11}
+{"abstract_id": "26035185", "label": "conclusions", "text": "Vortioxetine @ mg significantly reduced MADRS total score at @ weeks in this study population .", "sentence_id": 12}
+{"abstract_id": "26035185", "label": "conclusions", "text": "Overall , vortioxetine was well tolerated in this study .", "sentence_id": 13}
+{"abstract_id": "25516195", "label": "objective", "text": "Experimental evidence has indicated the benefits of simvastatin for the treatment of subarachnoid hemorrhage .", "sentence_id": 0}
+{"abstract_id": "25516195", "label": "objective", "text": "Two randomized placebo-controlled pilot trials that used the highest clinically approved dose of simvastatin ( @ mg daily ) gave positive results despite the fact that a lower dose of simvastatin ( @ mg daily ) did not improve clinical outcomes .", "sentence_id": 1}
+{"abstract_id": "25516195", "label": "objective", "text": "We hypothesized that a high dose of @ mg of simvastatin daily for @ weeks would reduce the incidence of delayed ischemic deficits after subarachnoid hemorrhage compared with a lower dose ( @ mg of simvastatin daily ) and lead to improved clinical outcomes .", "sentence_id": 2}
+{"abstract_id": "25516195", "label": "methods", "text": "The study design was a randomized controlled double-blinded clinical trial .", "sentence_id": 3}
+{"abstract_id": "25516195", "label": "methods", "text": "Patients with aneurysmal subarachnoid hemorrhage ( presenting within @ hours of the ictus ) from @ neurosurgical centers were recruited for @ years .", "sentence_id": 4}
+{"abstract_id": "25516195", "label": "methods", "text": "The primary outcome measure was the presence of delayed ischemic deficits , and secondary outcome measures included a modified Rankin disability score at @ months and an analysis of cost-effectiveness .", "sentence_id": 5}
+{"abstract_id": "25516195", "label": "results", "text": "No difference was observed between the groups treated with the higher dose or the lower dose of simvastatin in the incidence of delayed ischemic deficits ( @ % versus @ % ; odds ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) or in the rate of favorable outcomes ( modified Rankin Scale score , @-@ ) at @ months ( @ % versus @ % ; odds ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25516195", "label": "conclusions", "text": "High-dose simvastatin treatment should not be prescribed routinely for aneurysmal subarachnoid hemorrhage .", "sentence_id": 7}
+{"abstract_id": "24884753", "label": "objective", "text": "We examined the cost-effectiveness of an intervention to reduce coronary heart disease ( CHD ) risk and blood pressure in African Americans .", "sentence_id": 0}
+{"abstract_id": "24884753", "label": "methods", "text": "Stochastic cost-effectiveness analysis alongside a clinical trial , augmented by a Markov model of lifetime cost-effectiveness .", "sentence_id": 1}
+{"abstract_id": "24884753", "label": "methods", "text": "In @ urban academic primary care practices , we randomized African American patients with uncontrolled hypertension to a @-month intervention of office practice and peer coach behavioral support ( N = @ ) or informational brochures about CHD risk factors ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "24884753", "label": "methods", "text": "Costs were estimated from the perspective of the provider .", "sentence_id": 3}
+{"abstract_id": "24884753", "label": "methods", "text": "Outcomes included estimated CHD events avoided over @ months and reduction in systolic blood pressure ( SBP ) ( mm Hg ) .", "sentence_id": 4}
+{"abstract_id": "24884753", "label": "methods", "text": "Subgroup analysis was performed for compliers who received an `` effective '' dose of the peer coach and office staff visits .", "sentence_id": 5}
+{"abstract_id": "24884753", "label": "methods", "text": "Long-term cost-effectiveness was estimated by applying the clinical trial cost and effectiveness into a Markov model of CHD risk .", "sentence_id": 6}
+{"abstract_id": "24884753", "label": "results", "text": "The average cost for the behavioral support intervention group was $ @ compared with $ @ for the brochure control group .", "sentence_id": 7}
+{"abstract_id": "24884753", "label": "results", "text": "The incremental cost-effectiveness ratio ( ICER ) was $ @ per mm Hg reduction in SBP and $ @,@ per CHD event avoided in @ months .", "sentence_id": 8}
+{"abstract_id": "24884753", "label": "results", "text": "Modeled over a @-year horizon , the intervention had an ICER only as high as $ @ per incremental quality-adjusted life-year .", "sentence_id": 9}
+{"abstract_id": "24884753", "label": "conclusions", "text": "A community-primary care practice behavioral intervention to reduce hypertension in African Americans with sustained uncontrolled hypertension does not appear to be cost-effective in the first @ months .", "sentence_id": 10}
+{"abstract_id": "24884753", "label": "conclusions", "text": "If intervention results are sustained over the long term , the program may be cost-effective over the patient 's lifetime .", "sentence_id": 11}
+{"abstract_id": "24975869", "label": "objective", "text": "Our primary objective was to determine the proportion of patients with atrial fibrillation ( AF ) eligible for enrollment in a randomized controlled trial for a novel oral anticoagulant , the ARISTOTLE trial .", "sentence_id": 0}
+{"abstract_id": "24975869", "label": "objective", "text": "A secondary objective was to describe the reasons for trial ineligibility .", "sentence_id": 1}
+{"abstract_id": "24975869", "label": "methods", "text": "We performed a cross-sectional study of an unselected population including @ patients in Skellefte , Sweden with at least one verified episode of AF on or before December @ , @ .", "sentence_id": 2}
+{"abstract_id": "24975869", "label": "methods", "text": "Patients were classified as suitable or unsuitable for anticoagulant treatment according to current guidelines .", "sentence_id": 3}
+{"abstract_id": "24975869", "label": "methods", "text": "The enrollment criteria from the ARISTOTLE trial were extracted from the original publication and applied to the population .", "sentence_id": 4}
+{"abstract_id": "24975869", "label": "results", "text": "Among all patients with AF , @ were classified as suitable for anticoagulant treatment .", "sentence_id": 5}
+{"abstract_id": "24975869", "label": "results", "text": "Of these , only @ patients ( @ % ) were eligible for participation in the ARISTOTLE trial .", "sentence_id": 6}
+{"abstract_id": "24975869", "label": "results", "text": "Among the @ patients ineligible for participation , @ did not meet the ECG criteria , @ had psychosocial problems , and in addition , @ patients were excluded due to both of these criteria .", "sentence_id": 7}
+{"abstract_id": "24975869", "label": "conclusions", "text": "Our study shows that a majority of the patients in an unselected population with AF suitable for anticoagulant treatment were ineligible for participation in the ARISTOTLE trial .", "sentence_id": 8}
+{"abstract_id": "24975869", "label": "conclusions", "text": "The applicability of the ARISTOTLE trial is therefore unknown for a considerable proportion of patients with AF in real life .", "sentence_id": 9}
+{"abstract_id": "25380538", "label": "objective", "text": "The purpose of this study was to evaluate the safety and effectiveness of @-level total disc replacement ( TDR ) using a Mobi-C cervical artificial disc at @ months ' follow-up .", "sentence_id": 0}
+{"abstract_id": "25380538", "label": "methods", "text": "A prospective randomized , US FDA investigational device exemption pivotal trial of the Mobi-C cervical artificial disc was conducted at @ centers in the U.S. Three hundred thirty patients with degenerative disc disease were randomized and treated with cervical total disc replacement ( @ patients ) or the control treatment , anterior cervical discectomy and fusion ( ACDF ) ( @ patients ) .", "sentence_id": 1}
+{"abstract_id": "25380538", "label": "methods", "text": "Patients were followed up at regular intervals for @ years after surgery .", "sentence_id": 2}
+{"abstract_id": "25380538", "label": "results", "text": "At @ months , both groups demonstrated improvement in clinical outcome measures and a comparable safety profile .", "sentence_id": 3}
+{"abstract_id": "25380538", "label": "results", "text": "Data were available for @ TDR patients and @ ACDF patients in calculation of the primary endpoint .", "sentence_id": 4}
+{"abstract_id": "25380538", "label": "results", "text": "TDR patients had statistically significantly greater improvement than ACDF patients for the following outcome measures compared with baseline : Neck Disability Index scores , @-Item Short Form Health Survey Physical Component Summary scores , patient satisfaction , and overall success .", "sentence_id": 5}
+{"abstract_id": "25380538", "label": "results", "text": "ACDF patients experienced higher subsequent surgery rates and displayed a higher rate of adjacent-segment degeneration as seen on radiographs .", "sentence_id": 6}
+{"abstract_id": "25380538", "label": "results", "text": "Overall , TDR patients maintained segmental range of motion through @ months with no device failure .", "sentence_id": 7}
+{"abstract_id": "25380538", "label": "conclusions", "text": "Four-year results from this study continue to support TDR as a safe , effective , and statistically superior alternative to ACDF for the treatment of degenerative disc disease at @ contiguous cervical levels .", "sentence_id": 8}
+{"abstract_id": "25380538", "label": "conclusions", "text": "Clinical trial registration no. : NCT@ ( clinicaltrials.gov ) .", "sentence_id": 9}
+{"abstract_id": "25491714", "label": "objective", "text": "The objective of this study was to test the effect of a brief educational and counseling intervention on increasing the uptake of free testing for Chlamydia trachomatis ( chlamydia ) and Neisseria gonorrhea ( gonorrhea ) among young female emergency department ( ED ) patients .", "sentence_id": 0}
+{"abstract_id": "25491714", "label": "objective", "text": "Women are particularly vulnerable to more serious consequences of these infections due to asymptomatic presentation .", "sentence_id": 1}
+{"abstract_id": "25491714", "label": "objective", "text": "Increased testing is important to detect , treat , and halt the spread of these infections among asymptomatic women .", "sentence_id": 2}
+{"abstract_id": "25491714", "label": "methods", "text": "This was a randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "25491714", "label": "methods", "text": "Research assistants ( RAs ) approached female patients in two EDs .", "sentence_id": 4}
+{"abstract_id": "25491714", "label": "methods", "text": "Eligible patients were between @ and @ years of age , who reported having sex with males , but were not attending the ED for either treatment of sexually transmitted infection ( STI ) or testing for possible STI exposure .", "sentence_id": 5}
+{"abstract_id": "25491714", "label": "methods", "text": "Participants responded to survey questions about their lifetime and past @-month substance use , number of recent sexual partners , condom use , and perception of risks for chlamydia and gonorrhea infections .", "sentence_id": 6}
+{"abstract_id": "25491714", "label": "methods", "text": "Following the survey , the RAs randomized participants into study control or treatment arms .", "sentence_id": 7}
+{"abstract_id": "25491714", "label": "methods", "text": "Each treatment arm participant received a brief educational/counseling intervention from the RA .", "sentence_id": 8}
+{"abstract_id": "25491714", "label": "methods", "text": "The brief intervention focused on the woman 's personal risks for chlamydia and gonorrhea and condoms attitudes and usage .", "sentence_id": 9}
+{"abstract_id": "25491714", "label": "methods", "text": "As the primary outcome of this study , participants were offered free urine tests for chlamydia and gonorrhea infection postintervention or post-survey completion , depending on group assignment .", "sentence_id": 10}
+{"abstract_id": "25491714", "label": "results", "text": "A total of @ women completed the baseline assessment and were offered chlamydia and gonorrhea testing .", "sentence_id": 11}
+{"abstract_id": "25491714", "label": "results", "text": "The mean ( SD ) age was @ ( @ ) years , @ % were Hispanic , and @ % were Spanish-speaking only .", "sentence_id": 12}
+{"abstract_id": "25491714", "label": "results", "text": "The brief intervention that was offered to increase these women 's awareness of their STI risk did not result in increased acceptance of testing ; @ % in the brief intervention group accepted testing ( @ % confidence interval -LSB- CI -RSB- = @ % to @ % ) versus @ % in the control group ( @ % CI = @ % to @ % ) .", "sentence_id": 13}
+{"abstract_id": "25491714", "label": "results", "text": "In a multivariable logistic regression , only self-identifying as being Hispanic was associated with greater willingness to be tested .", "sentence_id": 14}
+{"abstract_id": "25491714", "label": "results", "text": "Of the asymptomatic women tested ( n = @ ) , five tested positive for chlamydia .", "sentence_id": 15}
+{"abstract_id": "25491714", "label": "results", "text": "This represents a positivity rate of @ % .", "sentence_id": 16}
+{"abstract_id": "25491714", "label": "results", "text": "There were no positive test results for gonorrhea .", "sentence_id": 17}
+{"abstract_id": "25491714", "label": "results", "text": "Women who reported high-risk factors for STI , such as younger age ( @ years ) , having sex in the past @ days without using condoms , identified substance use , or previous STI , were not more likely to accept the offer of chlamydia and gonorrhea testing .", "sentence_id": 18}
+{"abstract_id": "25491714", "label": "conclusions", "text": "The brief intervention used in this study did not increase the uptake of testing for chlamydia and gonorrhea infections in this sample , in comparison to receiving no intervention .", "sentence_id": 19}
+{"abstract_id": "25491714", "label": "conclusions", "text": "Although Hispanic women were more likely to accept chlamydia and gonorrhea testing , it is concerning that those women who report STI risk factors were not more likely to accept the offer of chlamydia and gonorrhea testing .", "sentence_id": 20}
+{"abstract_id": "25491714", "label": "conclusions", "text": "Future research should focus on the refinement of an intervention protocol to focus on prior STI and lack of condom use to increase the uptake of testing among this high-risk group .", "sentence_id": 21}
+{"abstract_id": "24557088", "label": "background", "text": "Preclinical studies support the hypothesis that endogenous neuroactive steroids mediate some effects of alcohol .", "sentence_id": 0}
+{"abstract_id": "24557088", "label": "objective", "text": "The aim of this study was to examine the effect of dutasteride inhibition of @-reduced neuroactive steroid production on subjective responses to alcohol in adult men .", "sentence_id": 1}
+{"abstract_id": "24557088", "label": "methods", "text": "Using a within-subject factorial design , @ men completed four randomly ordered monthly sessions in which pretreatment with @ mg dutasteride or placebo was paired with a moderate dose of alcohol ( @ g/kg ) or placebo beverage .", "sentence_id": 2}
+{"abstract_id": "24557088", "label": "methods", "text": "The pharmacologic effect of dutasteride was measured by an assay of serum androstanediol glucuronide .", "sentence_id": 3}
+{"abstract_id": "24557088", "label": "methods", "text": "Self-reports of alcohol effects were obtained at @-min intervals following alcohol administration using the Biphasic Alcohol Effects Scale ( BAES ) and the Alcohol Sensation Scale ( SS ) .", "sentence_id": 4}
+{"abstract_id": "24557088", "label": "methods", "text": "We used linear mixed models to examine the effects of dutasteride and alcohol on BAES and SS responses and the interaction of dutasteride with the GABRA@ alcohol dependence-associated polymorphism rs@ .", "sentence_id": 5}
+{"abstract_id": "24557088", "label": "methods", "text": "We also examined whether exposure to dutasteride influenced drinking in the weeks following each laboratory session .", "sentence_id": 6}
+{"abstract_id": "24557088", "label": "results", "text": "A single @-mg dose of dutasteride produced a @ % reduction in androstanediol glucuronide .", "sentence_id": 7}
+{"abstract_id": "24557088", "label": "results", "text": "Dutasteride pretreatment reduced alcohol effects on the BAES sedation and SS anesthesia scales .", "sentence_id": 8}
+{"abstract_id": "24557088", "label": "results", "text": "There was no interaction of dutasteride with rs@ .", "sentence_id": 9}
+{"abstract_id": "24557088", "label": "results", "text": "Heavy drinkers had fewer heavy drinking days during the @ weeks following the dutasteride sessions and fewer total drinks in the first week after dutasteride .", "sentence_id": 10}
+{"abstract_id": "24557088", "label": "conclusions", "text": "These results provide evidence that neuroactive steroids mediate some of the sedative effects of alcohol in adult men and that dutasteride may reduce drinking , presumably through its effects on neuroactive steroid concentrations .", "sentence_id": 11}
+{"abstract_id": "25054392", "label": "background", "text": "Tapentadol prolonged release ( PR ) is effective and well tolerated for chronic osteoarthritis , low back , and diabetic peripheral neuropathic pain .", "sentence_id": 0}
+{"abstract_id": "25054392", "label": "objective", "text": "To evaluate the efficacy and tolerability of tapentadol PR compared with placebo and morphine controlled release ( CR ) for managing moderate to severe chronic malignant tumor-related pain .", "sentence_id": 1}
+{"abstract_id": "25054392", "label": "methods", "text": "Randomized-withdrawal , parallel group , active - and placebo-controlled , double-blind phase @ study ( NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "25054392", "label": "methods", "text": "Primary , secondary , and tertiary care settings in @ countries .", "sentence_id": 3}
+{"abstract_id": "25054392", "label": "methods", "text": "Eligible patients ( pain intensity @ -LSB- @-point numerical rating scale -RSB- on prior analgesics ) were randomized ( @:@ ) and titrated to their optimal dose of tapentadol PR ( @-@ mg bid ) or morphine sulfate CR ( @-@ mg bid ) over @ weeks .", "sentence_id": 4}
+{"abstract_id": "25054392", "label": "methods", "text": "Morphine sulfate immediate release @ mg was permitted as needed for rescue medication ( no maximum dose ) .", "sentence_id": 5}
+{"abstract_id": "25054392", "label": "methods", "text": "Patients who completed titration and , during the last @ days of titration , had mean pain intensity < @ ( based on twice-daily ratings ) and mean rescue medication use = @ mg/day continued into a @-week maintenance period ; patients who received morphine CR during titration continued taking morphine CR , and those who received tapentadol PR were re-randomized ( @:@ ) to tapentadol PR or placebo bid .", "sentence_id": 6}
+{"abstract_id": "25054392", "label": "methods", "text": "Response during maintenance ( primary efficacy endpoint ) was defined as having : ( @ ) completed the maintenance period , ( @ ) a mean pain intensity < @ during maintenance , and ( @ ) used an average of = @ mg/day of rescue medication during maintenance .", "sentence_id": 7}
+{"abstract_id": "25054392", "label": "methods", "text": "Response at the end of titration was defined similarly , with pain intensity and rescue medication averages based on the last @ days of titration .", "sentence_id": 8}
+{"abstract_id": "25054392", "label": "results", "text": "Of @ patients screened , @ were randomized , treated during titration , and evaluable for safety ; @ were re-randomized , treated during maintenance , and evaluable for safety ; and @ were evaluable for efficacy .", "sentence_id": 9}
+{"abstract_id": "25054392", "label": "results", "text": "The adjusted responder rate estimate during maintenance ( logistic regression adjusting for treatment group , pooled center , and pain intensity at start of maintenance ) was significantly higher with tapentadol PR ( @ % ) than with placebo ( @ % ; odds ratio ( OR ) , @ -LSB- @ % confidence interval ( CI ) , @ - @ -RSB- ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25054392", "label": "results", "text": "Based on responder rates at the end of titration , tapentadol PR ( @ % -LSB- @/@ -RSB- ) was non-inferior to morphine CR ( @ % -LSB- @/@ -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "25054392", "label": "results", "text": "The lower limit of the @ % CI for the between-groups difference ( -@ % ) was within the pre-specified @ % non-inferiority margin .", "sentence_id": 12}
+{"abstract_id": "25054392", "label": "results", "text": "During titration , incidences of treatment-emergent adverse events ( TEAEs ) were @ % ( @/@ ) with tapentadol PR and @ % ( @/@ ) with morphine CR ; incidences of nausea , vomiting , and dry mouth were lower with tapentadol PR than with morphine CR .", "sentence_id": 13}
+{"abstract_id": "25054392", "label": "results", "text": "During maintenance , incidences of TEAEs were @ % ( @/@ ) , @ % ( @/@ ) , and @ % ( @/@ ) with placebo , tapentadol PR , and morphine CR , respectively .", "sentence_id": 14}
+{"abstract_id": "25054392", "label": "conclusions", "text": "Statistical comparisons between tapentadol PR and morphine CR were limited to descriptive statistics during the maintenance period because of the pre-selection of responders to tapentadol PR or morphine CR during titration .", "sentence_id": 15}
+{"abstract_id": "25054392", "label": "conclusions", "text": "Results obtained during maintenance indicate that tapentadol PR ( @-@ mg bid ) is effective compared with placebo for managing moderate to severe chronic malignant tumor-related pain .", "sentence_id": 16}
+{"abstract_id": "25054392", "label": "conclusions", "text": "Based on results obtained during titration , tapentadol PR provides comparable efficacy to that of morphine sulfate CR ( @-@ mg bid ) , but is associated with better gastrointestinal tolerability .", "sentence_id": 17}
+{"abstract_id": "25188774", "label": "objective", "text": "The aim of this study was to determine the effect of a single dose of @g of clonidine as an adjuvant to levobupivacaine ( Chirocaine ( ) ) in retrobulbar block on postoperative safety and analgesia .", "sentence_id": 0}
+{"abstract_id": "25188774", "label": "methods", "text": "This was a prospective , randomized , controlled , double-blind trial .", "sentence_id": 1}
+{"abstract_id": "25188774", "label": "methods", "text": "One hundred twenty patients with a rhegmatogenous retinal detachment scheduled to undergo external buckling surgery and cryocoagulation were asked to participate .", "sentence_id": 2}
+{"abstract_id": "25188774", "label": "methods", "text": "Participants were randomly assigned either to receive @-@mL Chirocaine ( @-@ @ mg ) or @-@mL Chirocaine and @mL clonidine ( @g ) before surgery .", "sentence_id": 3}
+{"abstract_id": "25188774", "label": "methods", "text": "Main outcome measures were postoperative pain , use of analgesics , blood pressure , and plasma clonidine concentration .", "sentence_id": 4}
+{"abstract_id": "25188774", "label": "methods", "text": "Nine nonrandomized patients consented to give blood samples for pharmacokinetic analysis .", "sentence_id": 5}
+{"abstract_id": "25188774", "label": "results", "text": "There was no significant difference in pain score between both groups .", "sentence_id": 6}
+{"abstract_id": "25188774", "label": "results", "text": "On average , the use of analgesic medication occurred later in the clonidine group ( P = @ ) , but there was no statistical difference in the first time that postoperative medication was taken ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25188774", "label": "results", "text": "Blood pressure was reduced by clonidine ( systolic : P = @ , diastolic : P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25188774", "label": "results", "text": "Clonidine levels could be demonstrated during the @-h postoperative period , with an average half-life of @h .", "sentence_id": 9}
+{"abstract_id": "25188774", "label": "conclusions", "text": "Administration of clonidine as an adjuvant to conventional retrobulbar block is safe , and delays the postoperative use of analgesics .", "sentence_id": 10}
+{"abstract_id": "25188774", "label": "conclusions", "text": "The reduction of postoperative pain and the time of first use of analgesic medication , however , were not significantly different between groups .", "sentence_id": 11}
+{"abstract_id": "25188774", "label": "conclusions", "text": "Further , pain scores in both study groups remained low .", "sentence_id": 12}
+{"abstract_id": "25188774", "label": "conclusions", "text": "Therefore , the beneficial effect of clonidine in conventional scleral buckle surgery appears to be limited .", "sentence_id": 13}
+{"abstract_id": "25560820", "label": "objective", "text": "Osteoporosis is a skeletal disorder characterized by impaired bone turnover and compromised bone strength , thereby predisposing to increased risk of fracture .", "sentence_id": 0}
+{"abstract_id": "25560820", "label": "objective", "text": "Preclinical research has shown that compounds produced by the olive tree ( Olea europaea ) , may protect from bone loss , by increasing osteoblast activity at the expense of adipocyte formation .", "sentence_id": 1}
+{"abstract_id": "25560820", "label": "objective", "text": "The aim of this exploratory study was to obtain a first insight on the effect of intake of an olive extract on bone turnover in postmenopausal women with decreased bone mass ( osteopenia ) .", "sentence_id": 2}
+{"abstract_id": "25560820", "label": "methods", "text": "For that , a double blind , placebo-controlled study was performed in which participants were randomly allocated to either treatment or placebo groups .", "sentence_id": 3}
+{"abstract_id": "25560820", "label": "methods", "text": "@ osteopenic patients , with a mean bone mineral density ( BMD ) T-score between -@ and -@ in the lumbar spine ( L@-L@ ) were included in the study .", "sentence_id": 4}
+{"abstract_id": "25560820", "label": "methods", "text": "PARTICIPANTS received for @ months daily either @ mg/day of olive extract and @ mg Ca ( treatment ) or @ mg Ca alone ( placebo ) .", "sentence_id": 5}
+{"abstract_id": "25560820", "label": "methods", "text": "Primary endpoints consisted of evaluation of bone turnover markers .", "sentence_id": 6}
+{"abstract_id": "25560820", "label": "methods", "text": "Secondary endpoints included BMD measurements and blood lipid profiles .", "sentence_id": 7}
+{"abstract_id": "25560820", "label": "results", "text": "After @ months , the levels of the pro-osteoblastic marker osteocalcin were found to significantly increase in the treatment group as compared to placebo .", "sentence_id": 8}
+{"abstract_id": "25560820", "label": "results", "text": "Simultaneously , BMD decreased in the placebo group , while remaining stable in the treatment group .", "sentence_id": 9}
+{"abstract_id": "25560820", "label": "results", "text": "In addition , improved lipid profiles were observed , with significant decrease in total - and LDL-cholesterol in the treatment group .", "sentence_id": 10}
+{"abstract_id": "25560820", "label": "conclusions", "text": "This exploratory study supports preclinical observations and warrants further research by showing that a specific olive polyphenol extract ( Bonolive ) affects serum osteocalcin levels and may stabilize lumbar spine BMD .", "sentence_id": 11}
+{"abstract_id": "25560820", "label": "conclusions", "text": "Moreover , the improved blood lipid profiles suggest additional health benefits associated to the intake of the olive polyphenol extract .", "sentence_id": 12}
+{"abstract_id": "25260762", "label": "background", "text": "Recruitment is a challenge in developing population-representative pregnancy and birth cohorts .", "sentence_id": 0}
+{"abstract_id": "25260762", "label": "methods", "text": "We developed a collaborative recruitment infrastructure ( CRI ) to recruit pregnant women for @ pregnancy cohorts using : faxes from obstetrical offices , in-clinic recruiters , university and funder-driven free-media events , paid-media , and attendance at relevant tradeshows .", "sentence_id": 1}
+{"abstract_id": "25260762", "label": "methods", "text": "Recruitment rates and demographic differences were compared between recruitment methods .", "sentence_id": 2}
+{"abstract_id": "25260762", "label": "results", "text": "We received @ referrals over @ months .", "sentence_id": 3}
+{"abstract_id": "25260762", "label": "results", "text": "Compared to fax , free-media referrals were @ times more likely to be recruited ( OR @ , @ % CI @ , @ : p < @ ) and paid-media referrals were @ times more likely to be recruited ( OR @ , @ % CI @ , @ : p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25260762", "label": "results", "text": "Among paid-media advertisements , free-to-read print ( e.g. Metro ) was the most effective ( OR @ , @ % CI @ , @ : p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25260762", "label": "results", "text": "Several demographic differences were identified between recruitment methods and against a reference population .", "sentence_id": 6}
+{"abstract_id": "25260762", "label": "results", "text": "Between recruitment methods , media recruits had a similar proportion families with incomes $ @,@ ( paid-media : @ % ; free-media : @ % ) compared to fax recruits ( @ % ) , while in-clinic recruits were less likely to have family incomes $ @,@ ( @ % , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25260762", "label": "results", "text": "Maternal recruits from fax and in-clinic were more likely to attend university ( Fax : @ % , in-clinic @ % ) versus the reference population ( @ % ; p < @ for both ) and both were less likely to smoke ( Fax : @ % , in-clinic @ % ) versus reference ( @ % ; p < @ for both ) .", "sentence_id": 8}
+{"abstract_id": "25260762", "label": "results", "text": "However , while fax referrals were more likely to be Caucasian ( @ % versus reference @ % ; p < @ ) , in-clinic referrals were not significantly different ( @ % ; P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25260762", "label": "conclusions", "text": "Recruitment methods result in different recruitment rates and participant demographics .", "sentence_id": 10}
+{"abstract_id": "25260762", "label": "conclusions", "text": "A variety of methods are required to recruit a generalizable sample .", "sentence_id": 11}
+{"abstract_id": "25064019", "label": "background", "text": "Research on contingency management to treat excessive alcohol use is limited due to feasibility issues with monitoring adherence .", "sentence_id": 0}
+{"abstract_id": "25064019", "label": "background", "text": "This study examined the effectiveness of using transdermal alcohol monitoring as a continuous measure of alcohol use to implement financial contingencies to reduce heavy drinking .", "sentence_id": 1}
+{"abstract_id": "25064019", "label": "methods", "text": "Twenty-six male and female drinkers ( from @ to @ years old ) were recruited from the community .", "sentence_id": 2}
+{"abstract_id": "25064019", "label": "methods", "text": "Participants were randomly assigned to one of the two treatment sequences .", "sentence_id": 3}
+{"abstract_id": "25064019", "label": "methods", "text": "Sequence @ received @ weeks of no financial contingency ( i.e. , $ @ ) drinking followed by @ weeks each of $ @ and then $ @ contingency management ; Sequence @ received @ weeks of $ @ contingency management followed by @ weeks each of no contingency ( i.e. , $ @ ) and then $ @ contingency management .", "sentence_id": 4}
+{"abstract_id": "25064019", "label": "methods", "text": "During the $ @ and $ @ contingency management conditions , participants were paid each week when the Secure Continuous Remote Alcohol Monitor ( SCRAM-II ) identified no heavy drinking days .", "sentence_id": 5}
+{"abstract_id": "25064019", "label": "results", "text": "Participants in both contingency management conditions had fewer drinking episodes and reduced frequencies of heavy drinking compared to the $ @ condition .", "sentence_id": 6}
+{"abstract_id": "25064019", "label": "results", "text": "Participants randomized to Sequence @ ( receiving $ @ contingency before the $ @ condition ) exhibited less frequent drinking and less heavy drinking in the $ @ condition compared to participants from Sequence @ .", "sentence_id": 7}
+{"abstract_id": "25064019", "label": "conclusions", "text": "Transdermal alcohol monitoring can be used to implement contingency management programs to reduce excessive alcohol consumption .", "sentence_id": 8}
+{"abstract_id": "26194675", "label": "objective", "text": "In the European HIT-SIOP PNET@ randomized controlled trial , children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy ( HFRT arm , including a partially focused boost ) or standard radiation therapy ( STRT arm ) , followed , in both arms , by maintenance chemotherapy .", "sentence_id": 0}
+{"abstract_id": "26194675", "label": "objective", "text": "Event-free survival was similar in both arms .", "sentence_id": 1}
+{"abstract_id": "26194675", "label": "objective", "text": "Previous work showed that the HFRT arm was associated with worse growth and better questionnaire-based executive function , especially in children < @years of age at diagnosis .", "sentence_id": 2}
+{"abstract_id": "26194675", "label": "objective", "text": "Therefore , the aim of this study was to compare performance-based cognitive outcomes between treatment arms .", "sentence_id": 3}
+{"abstract_id": "26194675", "label": "methods", "text": "Neuropsychological data were collected prospectively in @ patients .", "sentence_id": 4}
+{"abstract_id": "26194675", "label": "methods", "text": "Using the Wechsler Intelligence Scales , Kaufman Assessment Battery for Children , and Raven 's Progressive Matrices , we estimated full-scale intelligence quotient ( FSIQ ) and , when available , verbal IQ ( VIQ ) , performance IQ ( PIQ ) , working memory index ( WMI ) , and processing speed index ( PSI ) .", "sentence_id": 5}
+{"abstract_id": "26194675", "label": "results", "text": "Among the @ participants ( HFRT arm n = @ , STRT arm n = @ , @ % males ) , mean ( SD ) ages at diagnosis and assessment respectively were @ ( @ ) years of age ( @ % < @years of age at diagnosis ) and @ ( @ ) years of age .", "sentence_id": 6}
+{"abstract_id": "26194675", "label": "results", "text": "Mean ( SD ) FSIQ was @ ( @ ) , and mean intergroup difference was @ ( @ % confidence interval : -@ to @ , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26194675", "label": "results", "text": "No significant differences were found in children > @years of age at diagnosis .", "sentence_id": 8}
+{"abstract_id": "26194675", "label": "results", "text": "In children < @years of age at diagnosis , a marginally significant trend toward higher VIQ was found in those treated in the HFRT arm ; a similar trend was found for PSI but not for PIQ , WMI , or FSIQ ( mean intergroup differences were : @ for VIQ -LSB- @ % CI : @-@ @ ; P = @ -RSB- ; @ for PIQ -LSB- @ % CI : -@ to @ ; P > @ -RSB- ; @ for WMI -LSB- @ % CI : -@ to @ ; P > @ -RSB- ; @ for PSI -LSB- @ % CI : -@ to @ ; P = @ -RSB- ; and @ for FSIQ -LSB- @ % CI : -@ to @ ; P > @ -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "26194675", "label": "conclusions", "text": "HFRT was associated with marginally higher VIQ in children < @years of age at diagnosis , consistent with a previous report using questionnaire-based data .", "sentence_id": 10}
+{"abstract_id": "26194675", "label": "conclusions", "text": "However , overall cognitive ability was not significantly different .", "sentence_id": 11}
+{"abstract_id": "24628437", "label": "objective", "text": "Compare the treatment outcome after scaling and root-planing using local anesthesia gel or injected local anesthesia .", "sentence_id": 0}
+{"abstract_id": "24628437", "label": "methods", "text": "Thirty-eight patients with periodontitis and good general health were included in a randomized , single-blind , split-mouth clinical trial .", "sentence_id": 1}
+{"abstract_id": "24628437", "label": "methods", "text": "Probing depths and clinical attachment levels were recorded at baseline and @weeks after treatment .", "sentence_id": 2}
+{"abstract_id": "24628437", "label": "methods", "text": "Performed treatment procedures were scaling and root planing using two types of local anesthesia for separate treatment appointments .", "sentence_id": 3}
+{"abstract_id": "24628437", "label": "methods", "text": "Anesthetics used were intra-pocket lidocaine and prilocaine gel ( @ % each ) and injected articaine ( @:@,@ adrenaline ) .", "sentence_id": 4}
+{"abstract_id": "24628437", "label": "methods", "text": "Type of anesthesia for first appointment was randomized and switched for second appointment .", "sentence_id": 5}
+{"abstract_id": "24628437", "label": "methods", "text": "Patients ' pain perception and anesthesia acceptance were recorded on questionnaires .", "sentence_id": 6}
+{"abstract_id": "24628437", "label": "results", "text": "No influence of applied type of anesthesia could be detected for change of probing pocket depths and clinical attachment level ( p > @ ) .", "sentence_id": 7}
+{"abstract_id": "24628437", "label": "results", "text": "These findings are valid even for deeper pockets .", "sentence_id": 8}
+{"abstract_id": "24628437", "label": "results", "text": "Gel-group had significant higher intra-operative pain perception .", "sentence_id": 9}
+{"abstract_id": "24628437", "label": "results", "text": "In retrospect @ % of patients favored gel .", "sentence_id": 10}
+{"abstract_id": "24628437", "label": "conclusions", "text": "Treatment outcome is not compromised by use of anesthesia gel in comparison to injected anesthesia .", "sentence_id": 11}
+{"abstract_id": "24628437", "label": "conclusions", "text": "The same beneficial results for probing pocket depths and clinical attachment gain could be detected .", "sentence_id": 12}
+{"abstract_id": "24628437", "label": "conclusions", "text": "The majority of patients prefer local anesthesia gel despite a slightly greater procedural discomfort .", "sentence_id": 13}
+{"abstract_id": "24548447", "label": "objective", "text": "To explore the clinical values of detecting drug related molecules excision repair cross complementing @ ( ERCC@ ) and top-isomerase I ( TOPO I ) in individualized therapies of metastatic colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "24548447", "label": "methods", "text": "From June @ to December @ , @ patients at Huadong Hospital with metastatic colorectal cancer were randomly separated into @ groups after operation .", "sentence_id": 1}
+{"abstract_id": "24548447", "label": "methods", "text": "Each group had @ patients without difference in gender , age or TNM stage .", "sentence_id": 2}
+{"abstract_id": "24548447", "label": "methods", "text": "The expressions of ERCC@ and TOPO Iin cancer tissues were detected by immunohistochemical staining .", "sentence_id": 3}
+{"abstract_id": "24548447", "label": "methods", "text": "The testing group received individualized chemotherapies following the expression results while the control group had random chemotherapies .", "sentence_id": 4}
+{"abstract_id": "24548447", "label": "methods", "text": "The survival difference between two groups was analyzed by log-rank test and Kaplan-Meier analysis .", "sentence_id": 5}
+{"abstract_id": "24548447", "label": "methods", "text": "And curative effect was analyzed by ( @ ) or Fisher 's analysis .", "sentence_id": 6}
+{"abstract_id": "24548447", "label": "results", "text": "The expressions of ERCC@ and TOPO I had no statistical significance between two groups ( both P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24548447", "label": "results", "text": "In the testing group , the median survival time was @ days and the beneficial ratio @ % ( @/@ ) versus @ days and @ % ( @/@ ) respectively in the control group .", "sentence_id": 8}
+{"abstract_id": "24548447", "label": "results", "text": "The inter-group comparisons of survival ( P = @ ) and curative effect ( ( @ ) = @ , P > @ ) showed no statistical significance .", "sentence_id": 9}
+{"abstract_id": "24548447", "label": "results", "text": "In the estimated drug tolerated group ( ERCC@ high expression or TOPO I low expression ) , the median survival time was @ days and the beneficial ratio @/@ versus @ days and @ % ( @/@ ) in the estimated drug sensitive group .", "sentence_id": 10}
+{"abstract_id": "24548447", "label": "results", "text": "The inter-group comparisons of survival and curative effect ( both P < @ ) had statistical significance .", "sentence_id": 11}
+{"abstract_id": "24548447", "label": "results", "text": "The median survival time and beneficial ratio significantly increased in estimated drug sensitive group than those in estimated drug tolerated group .", "sentence_id": 12}
+{"abstract_id": "24548447", "label": "conclusions", "text": "The expression of drug related molecule in colorectal cancer tissue is significantly associated with curative effect in patients .", "sentence_id": 13}
+{"abstract_id": "24548447", "label": "conclusions", "text": "Patients with down-regulated ERCC@ on Oxaliplatin or up-regulated TOPO Ion Irinotecan have longer survival and better curative effect .", "sentence_id": 14}
+{"abstract_id": "24548447", "label": "conclusions", "text": "And chemotherapies guided by drug related molecule detection may boost curative effects in metastatic colorectal cancer .", "sentence_id": 15}
+{"abstract_id": "25411159", "label": "background", "text": "Biodegradable-polymer drug-eluting stents ( BP-DES ) were developed to be as effective as second-generation durable-polymer drug-eluting stents ( DP-DES ) and as safe > @ year as bare-metal stents ( BMS ) .", "sentence_id": 0}
+{"abstract_id": "25411159", "label": "background", "text": "Thus , very late stent thrombosis ( VLST ) attributable to durable polymers should no longer appear .", "sentence_id": 1}
+{"abstract_id": "25411159", "label": "results", "text": "To address these early and late aspects , @ patients presenting with acute or stable coronary disease needing stents @ mm in diameter between April @ and May @ were randomly assigned to biolimus-A@-eluting BP-DES , second-generation everolimus-eluting DP-DES , or thin-strut silicon-carbide-coated BMS in @ European centers .", "sentence_id": 2}
+{"abstract_id": "25411159", "label": "results", "text": "All patients were treated with aspirin and risk-adjusted doses of prasugrel .", "sentence_id": 3}
+{"abstract_id": "25411159", "label": "results", "text": "The primary end point was combined cardiac death , myocardial infarction , and clinically indicated target-vessel revascularization within @ years .", "sentence_id": 4}
+{"abstract_id": "25411159", "label": "results", "text": "The combined secondary safety end point was a composite of VLST , myocardial infarction , and cardiac death .", "sentence_id": 5}
+{"abstract_id": "25411159", "label": "results", "text": "The cumulative incidence of the primary end point was @ % with BP-DES , @ % with DP-DES , and @ % with BMS .", "sentence_id": 6}
+{"abstract_id": "25411159", "label": "results", "text": "By intention-to-treat BP-DES were noninferior ( predefined margin , @ % ) compared with DP-DES ( absolute risk difference , @ % ; -@ % to @ % ; P for noninferiority @ ; per protocol P = @ ) and superior to BMS ( absolute risk difference , -@ ; -@ to -@ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25411159", "label": "results", "text": "The @ stent groups did not differ in the combined safety end point , with no decrease in events > @ year , particularly VLST with BP-DES .", "sentence_id": 8}
+{"abstract_id": "25411159", "label": "conclusions", "text": "In large vessel stenting , BP-DES appeared barely noninferior compared with DP-DES and more effective than thin-strut BMS , but without evidence for better safety nor lower VLST rates > @ year .", "sentence_id": 9}
+{"abstract_id": "25411159", "label": "conclusions", "text": "Findings challenge the concept that durable polymers are key in VLST formation .", "sentence_id": 10}
+{"abstract_id": "25136048", "label": "background", "text": "The World Health Organization recommends vitamin A supplementation ( VAS ) at routine vaccination contacts after @ months of age based on the assumption that it reduces mortality by @ % .", "sentence_id": 0}
+{"abstract_id": "25136048", "label": "background", "text": "The policy has never been evaluated in randomized controlled trials for its effect on overall mortality .", "sentence_id": 1}
+{"abstract_id": "25136048", "label": "background", "text": "We conducted a randomized double-blind trial to evaluate the effect of VAS with vaccines .", "sentence_id": 2}
+{"abstract_id": "25136048", "label": "methods", "text": "We randomized children aged @ to @ months @:@ to VAS ( @ IU if aged @-@ months , @ IU if aged @-@ months ) or placebo at vaccination contacts in Guinea-Bissau .", "sentence_id": 3}
+{"abstract_id": "25136048", "label": "methods", "text": "Mortality rates were compared in Cox proportional-hazards models overall , and by gender and vaccine .", "sentence_id": 4}
+{"abstract_id": "25136048", "label": "results", "text": "Between August @ and November @ , @ children were enrolled .", "sentence_id": 5}
+{"abstract_id": "25136048", "label": "results", "text": "Within @ months of follow-up @ nonaccident deaths occurred ( VAS : @ ; placebo : @ ) .", "sentence_id": 6}
+{"abstract_id": "25136048", "label": "results", "text": "The mortality rate ratio ( MRR ) comparing VAS versus placebo recipients was @ ( @ % confidence interval @-@ @ ) and differed significantly between boys ( MRR @ -LSB- @-@ @ -RSB- ) and girls ( MRR @ -LSB- @-@ @ -RSB- ) ( P = @ for interaction between VAS and gender ) .", "sentence_id": 7}
+{"abstract_id": "25136048", "label": "results", "text": "At enrollment , @ % ( @/@ ) received live measles vaccine , @ % ( @/@ ) received inactivated diphtheria-tetanus-pertussis-containing vaccines , and @ % ( @/@ ) received both live and inactivated vaccines .", "sentence_id": 8}
+{"abstract_id": "25136048", "label": "results", "text": "The effect of VAS did not differ by vaccine group .", "sentence_id": 9}
+{"abstract_id": "25136048", "label": "conclusions", "text": "This is the first randomized controlled trial to assess the effect of the policy on overall mortality .", "sentence_id": 10}
+{"abstract_id": "25136048", "label": "conclusions", "text": "VAS had no overall effect , but the effect differed significantly by gender .", "sentence_id": 11}
+{"abstract_id": "25136048", "label": "conclusions", "text": "More trials to ensure an optimal evidence-based vitamin A policy are warranted .", "sentence_id": 12}
+{"abstract_id": "24565243", "label": "objective", "text": "Sedation-analgesia is recommended for comfortable colonoscopy procedures , which are invasive and can be painful .", "sentence_id": 0}
+{"abstract_id": "24565243", "label": "objective", "text": "This study aimed to compare the combinations of propofol-alfentanil and propofol-fentanyl for sedation-analgesia in elective colonoscopy patients .", "sentence_id": 1}
+{"abstract_id": "24565243", "label": "methods", "text": "This prospective and randomized study was planned in ASA I-II groups and included @ patients between the ages of @ and @ years .", "sentence_id": 2}
+{"abstract_id": "24565243", "label": "methods", "text": "Sedation-analgesia induction was performed as @ g.kg ( -@ ) fentanyl , @mg .", "sentence_id": 3}
+{"abstract_id": "24565243", "label": "methods", "text": "kg ( -@ ) propofol in the propofol-fentanyl group ( Group PF ) and @ g.kg ( -@ ) alfentanil , @mg .", "sentence_id": 4}
+{"abstract_id": "24565243", "label": "methods", "text": "kg ( -@ ) propofol in the propofol-alfentanil group ( Group PA ) .", "sentence_id": 5}
+{"abstract_id": "24565243", "label": "methods", "text": "Patients ' scores were limited to @-@ values on the Ramsey Sedation Scale ( RSS ) by @ mg.kg ( -@ ) bolus additional doses of propofol in sedation-analgesia maintenance .", "sentence_id": 6}
+{"abstract_id": "24565243", "label": "methods", "text": "We recorded demographical data , heart rate , mean arterial pressure ( MAP ) , oxygen saturation of hemoglobin ( SpO@ ) , RSS value , colonoscopy time , total dose of propofol , complications , recovery time , and discharge time , as well as colonoscopist and patient satisfaction scores .", "sentence_id": 7}
+{"abstract_id": "24565243", "label": "results", "text": "MAP at the @ ( th ) minute in Group PA was significantly higher than in Group PF ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24565243", "label": "results", "text": "Group PA 's beginning mean heart rate was higher than the mean heart rate at subsequent readings ( p = @ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24565243", "label": "results", "text": "The mean total propofol dose of Group PA was significantly higher than the total dose of Group PF ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24565243", "label": "results", "text": "The mean recovery time of Group PA was significantly longer than that of Group PF ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24565243", "label": "conclusions", "text": "Fentanyl provides better operative conditions and reduces the need for additional propofol doses .", "sentence_id": 12}
+{"abstract_id": "24565243", "label": "conclusions", "text": "These advantages cause a shorter recovery time .", "sentence_id": 13}
+{"abstract_id": "24565243", "label": "conclusions", "text": "Therefore , propofol-fentanyl is superior to the propofol-alfentanil for sedation-analgesia in colonoscopy .", "sentence_id": 14}
+{"abstract_id": "24494737", "label": "objective", "text": "To investigate the immediate effects of manipulation of bilateral sacroiliac joints ( SIJs ) on the plantar pressure distribution in asymptomatic participants in the standing position .", "sentence_id": 0}
+{"abstract_id": "24494737", "label": "methods", "text": "Randomized , controlled , double-blind clinical trial .", "sentence_id": 1}
+{"abstract_id": "24494737", "label": "methods", "text": "Sixty-two asymptomatic men and women ( mean age , @ years ) randomly assigned to @ groups .", "sentence_id": 2}
+{"abstract_id": "24494737", "label": "methods", "text": "The experimental group underwent mobilization without tension of the hips in the supine position and high-velocity , low-amplitude manipulation in the SIJs bilaterally .", "sentence_id": 3}
+{"abstract_id": "24494737", "label": "methods", "text": "The control group underwent only mobilization , without tension of the hips in supine position .", "sentence_id": 4}
+{"abstract_id": "24494737", "label": "methods", "text": "Pre - and postintervention outcomes measured by an assessor blinded to the treatment allocation of the participants included a baropodometric analysis performed by using a force platform .", "sentence_id": 5}
+{"abstract_id": "24494737", "label": "methods", "text": "Baseline between-group differences were examined with a Kolmogorov-Smirnov test .", "sentence_id": 6}
+{"abstract_id": "24494737", "label": "methods", "text": "A chi-square test was used for categorical data .", "sentence_id": 7}
+{"abstract_id": "24494737", "label": "methods", "text": "Analysis of covariance ( ANCOVA ) was used to assess differences between groups , with the preintervention value as covariant ( @ % confidence level ) .", "sentence_id": 8}
+{"abstract_id": "24494737", "label": "results", "text": "At baseline , no variables significantly differed between groups .", "sentence_id": 9}
+{"abstract_id": "24494737", "label": "results", "text": "Baropodometric analysis showed statistically significant differences in the location of the maximum pressure point in the experimental group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24494737", "label": "results", "text": "Pre - and postintervention analysis with ANCOVA showed statistically significant differences between both groups in the left hindfoot load percentage ( interaction p = @ ; ANCOVA p = @ ) , right foot load percentage ( ANCOVA p = @ ) , and surface of the right forefoot ( interaction p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24494737", "label": "results", "text": "There was also a significant effect in the variables that analyze the entire foot ( left foot : surface -LSB- interaction p = @ -RSB- , percentage of load -LSB- ANCOVA p = @ -RSB- ) and between both groups ( right foot : weight -LSB- interaction p = @ ; ANCOVA p = @ -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "24494737", "label": "conclusions", "text": "Sacroiliac joint manipulation applied bilaterally in asymptomatic persons resulted in immediate changes in load distribution on plantar support in the standing position .", "sentence_id": 13}
+{"abstract_id": "24494737", "label": "conclusions", "text": "Study limitations and suggestions for future studies are discussed .", "sentence_id": 14}
+{"abstract_id": "24452849", "label": "background", "text": "New-onset diabetes after transplantation ( NODAT ) is a common complication after renal transplantation .", "sentence_id": 0}
+{"abstract_id": "24452849", "label": "background", "text": "There are limited available oral drugs to treat hyperglycaemia in this population owing to reduced renal function , potential interactions with immunosuppressive drugs and adverse effects such as hypoglycaemic events that may increase the cardiovascular risk .", "sentence_id": 1}
+{"abstract_id": "24452849", "label": "background", "text": "This study was initiated to investigate efficacy and safety of sitagliptin treatment that may represent a novel alternative in renal transplant recipients .", "sentence_id": 2}
+{"abstract_id": "24452849", "label": "methods", "text": "Nineteen long-term stable renal transplant recipients with NODAT were included in a controlled , cross-over study and randomized to first receive either sitagliptin @-@ mg/day or a sitagliptin-free period of @ weeks .", "sentence_id": 3}
+{"abstract_id": "24452849", "label": "methods", "text": "Median age ( interquartile range , IQR ) was @ ( @-@ ) years ( @ males/@ females ) , all studied @ ( @-@ ) year after transplantation .", "sentence_id": 4}
+{"abstract_id": "24452849", "label": "methods", "text": "The immunosuppressive regimen was a triple calcineurin inhibitor-based therapy .", "sentence_id": 5}
+{"abstract_id": "24452849", "label": "methods", "text": "Oral glucose tolerance test ( OGTT ) with insulin and C-peptide responses and laser Doppler ( LD ) flowmetry assessment of endothelial function were performed at baseline and after each treatment period .", "sentence_id": 6}
+{"abstract_id": "24452849", "label": "methods", "text": "Home measurements of plasma glucose were performed daily during the study .", "sentence_id": 7}
+{"abstract_id": "24452849", "label": "results", "text": "The median ( IQR ) first - and second-phase insulin secretion responses increased significantly by @ % ( @-@ @ % , P = @ ) and @ % ( @-@ @ % , P = @ ) , respectively , following sitagliptin treatment as compared with no sitagliptin treatment .", "sentence_id": 8}
+{"abstract_id": "24452849", "label": "results", "text": "Fasting and @-h plasma glucose concentrations fell significantly -LCB- @ mmol/L -LSB- @-@ @ mmol/L ( @ mg/dL ) , P = @ -RSB- and @ mmol/L -LSB- @-@ @ mmol/L ( @ mg/dL ) , P = @ -RSB- , respectively -RCB- , as did also home measurements of plasma glucose .", "sentence_id": 9}
+{"abstract_id": "24452849", "label": "results", "text": "Endothelial function and plasma markers of cardiovascular risk were unaffected .", "sentence_id": 10}
+{"abstract_id": "24452849", "label": "results", "text": "No serious adverse events were observed .", "sentence_id": 11}
+{"abstract_id": "24452849", "label": "results", "text": "Two mild and asymptomatic hypoglycaemic episodes were observed in combination with glipizide .", "sentence_id": 12}
+{"abstract_id": "24452849", "label": "conclusions", "text": "Sitagliptin increases insulin secretion and reduces fasting and postprandial plasma glucose in renal transplant recipients with NODAT .", "sentence_id": 13}
+{"abstract_id": "24452849", "label": "conclusions", "text": "The short-term treatment was well tolerated , and sitagliptin seems safe in this population .", "sentence_id": 14}
+{"abstract_id": "24393424", "label": "background", "text": "Sepsis , a leading cause of death in critically ill patients , is the result of complex interactions between the infecting microorganisms and the host responses that influence clinical outcomes .", "sentence_id": 0}
+{"abstract_id": "24393424", "label": "background", "text": "We evaluated the prognostic value of presepsin ( sCD@-ST ) , a novel biomarker of bacterial infection , and compared it with procalcitonin ( PCT ) .", "sentence_id": 1}
+{"abstract_id": "24393424", "label": "methods", "text": "This is a retrospective , case-control study of a multicenter , randomized clinical trial enrolling patients with severe sepsis or septic shock in ICUs in Italy .", "sentence_id": 2}
+{"abstract_id": "24393424", "label": "methods", "text": "We selected @ survivors and @ non-survivors at ICU discharge , matched for age , sex and time from sepsis diagnosis to enrollment .", "sentence_id": 3}
+{"abstract_id": "24393424", "label": "methods", "text": "Plasma samples were collected @ , @ and @ days after enrollment to assay presepsin and PCT .", "sentence_id": 4}
+{"abstract_id": "24393424", "label": "methods", "text": "Outcome was assessed @ and @ days after enrollment .", "sentence_id": 5}
+{"abstract_id": "24393424", "label": "results", "text": "Early presepsin ( day @ ) was higher in decedents ( @,@ pg/ml , median ( Q@ to Q@ ) , @,@ to @,@ pg/ml ) than in survivors ( @,@ pg/ml ( median , @ to @,@ ) ; P = @ ) , whereas PCT was not different ( @ g/L ( median @ to @ ) and @ g/L ( @ to @ ) ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24393424", "label": "results", "text": "The evolution of presepsin levels over time was significantly different in survivors compared to decedents ( P for time-survival interaction = @ ) , whereas PCT decreased similarly in the two groups ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24393424", "label": "results", "text": "Presepsin was the only variable independently associated with ICU and @-day mortality in Cox models adjusted for clinical characteristics .", "sentence_id": 8}
+{"abstract_id": "24393424", "label": "results", "text": "It showed better prognostic accuracy than PCT in the range of Sequential Organ Failure Assessment score ( area under the curve ( AUC ) from @ to @ vs. AUC @ to @ ) .", "sentence_id": 9}
+{"abstract_id": "24393424", "label": "conclusions", "text": "In this multicenter clinical trial , we provide the first evidence that presepsin measurements may have useful prognostic information for patients with severe sepsis or septic shock .", "sentence_id": 10}
+{"abstract_id": "24393424", "label": "conclusions", "text": "These preliminary findings suggest that presepsin may be of clinical importance for early risk stratification .", "sentence_id": 11}
+{"abstract_id": "25600720", "label": "objective", "text": "To compare the efficacy of celecoxib for treatment of withdrawal headache vs prednisone in patients with medication overuse headache ( MOH ) .", "sentence_id": 0}
+{"abstract_id": "25600720", "label": "methods", "text": "In this prospective , double-blind , parallel-group clinical trial , @ consecutive subjects with MOH were randomized ( simple randomization using computer-generated numbers ) for treatment with either @mg/day celecoxib ( for the first @ days then decreased at a rate of @mg every @ days ) or prednisone @ mg/day orally ( for the first @ days then tapered off every @ days ) .", "sentence_id": 1}
+{"abstract_id": "25600720", "label": "methods", "text": "Subjects who met the International Headache Society criteria for MOH were included in the trial .", "sentence_id": 2}
+{"abstract_id": "25600720", "label": "methods", "text": "The change in headache days and intake of rescue medication were considered as primary outcomes while the change in headache severity defined as a secondary outcome .", "sentence_id": 3}
+{"abstract_id": "25600720", "label": "results", "text": "Patients treated with celecoxib experienced lower headache intensity during the first @ weeks after withdrawal ( after @ weeks , the median of visual analog scale was @ for patients in celecoxib group vs @ for prednisone group -LSB- P < @ -RSB- ) .", "sentence_id": 4}
+{"abstract_id": "25600720", "label": "results", "text": "However , headache frequency and the need for rescue medication intake were not different between @ groups .", "sentence_id": 5}
+{"abstract_id": "25600720", "label": "conclusions", "text": "During withdrawal in MOH , in order to reduce headache days or rescue medication intake , using either of celecoxib or prednisone as a bridge is not different .", "sentence_id": 6}
+{"abstract_id": "25280410", "label": "objective", "text": "Short-term dietary glucose supplementation has been shown to accelerate the gastric emptying rate of both glucose and fructose solutions .", "sentence_id": 0}
+{"abstract_id": "25280410", "label": "objective", "text": "The aim of this study was to examine gastric emptying rate responses to monosaccharide ingestion following short-term dietary fructose supplementation .", "sentence_id": 1}
+{"abstract_id": "25280410", "label": "methods", "text": "The gastric emptying rate of a fructose solution containing @ g of fructose and an equicaloric glucose solution containing @ g glucose monohydrate were measured in @ healthy non-smoking men with and without prior fructose supplementation ( water control ) using a randomized crossover design .", "sentence_id": 2}
+{"abstract_id": "25280410", "label": "methods", "text": "Gastric emptying rate was assessed for a period of @ h using the -LSB- ( @ ) C -RSB- breath test with sample collections at baseline and @-min intervals following drink ingestion .", "sentence_id": 3}
+{"abstract_id": "25280410", "label": "methods", "text": "Additionally , appetite ratings of hunger , fullness , and prospective food consumption were recorded at baseline and every @ min using visual analog scales .", "sentence_id": 4}
+{"abstract_id": "25280410", "label": "results", "text": "Increased dietary fructose ingestion resulted in significantly accelerated half-emptying time of a fructose solution ( mean = @ , SD = @ versus @ , SD = @ min control ; P = @ ) , whereas the emptying of a glucose solution remained unchanged ( mean = @ , SD = @ versus @ , SD = @ min control ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25280410", "label": "results", "text": "Time of maximal emptying rate of fructose was also significantly accelerated following increased dietary fructose intake ( mean = @ , SD = @ versus @ , SD = @ min control ; P = @ ) , while it remained unchanged for glucose ( mean = @ , SD = @ versus @ , SD = @ min control ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25280410", "label": "results", "text": "No effects of supplementation were observed for appetite measures .", "sentence_id": 7}
+{"abstract_id": "25280410", "label": "conclusions", "text": "Three d of supplementation with @ g/d of fructose resulted in an acceleration of gastric emptying rate of a fructose solution but not a glucose solution .", "sentence_id": 8}
+{"abstract_id": "26248345", "label": "objective", "text": "To evaluate intraocular lens ( IOL ) axial movements and refractive changes during a @-month follow-up period after femtosecond laser-assisted cataract surgery and conventional cataract surgery , investigate the influence of capsulorhexis features on postoperative IOL axial changes , and assess the prediction error for both techniques .", "sentence_id": 0}
+{"abstract_id": "26248345", "label": "methods", "text": "Eighty eyes of @ candidates for cataract extraction were randomized into two groups : femtosecond laser ( @ eyes ) and manual ( @ eyes ) .", "sentence_id": 1}
+{"abstract_id": "26248345", "label": "results", "text": "The overall anterior chamber depth variation was significantly lower in the femtosecond laser group compared to the manual group during follow-up ( P < @ ) .", "sentence_id": 2}
+{"abstract_id": "26248345", "label": "results", "text": "At @ and @ days postoperatively , the mean spherical equivalent showed a hyperopic shift ( @ diopters -LSB- D -RSB- ) in the femtosecond laser group and a myopic shift in the manual group ( -@ D ) .", "sentence_id": 3}
+{"abstract_id": "26248345", "label": "results", "text": "Median absolute error was not significantly different between the two groups with standard formulas ranging between @ and @ ( Hoffer Q ) in the femtosecond laser group and between @ ( SRK-T ) and @ D ( Hoffer Q ) in the manual group .", "sentence_id": 4}
+{"abstract_id": "26248345", "label": "results", "text": "There was a significant lower deviation from intended versus achieved capsulotomy/capsulorhexis area in the femtosecond laser group ( P < @ ) compared to the manual group .", "sentence_id": 5}
+{"abstract_id": "26248345", "label": "results", "text": "The femtosecond laser group showed better IOL centration compared to the manual group at all time periods ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "26248345", "label": "conclusions", "text": "Femtosecond laser-assisted cataract surgery was related to a lower overall variability of anterior chamber depth compared to conventional cataract surgery with more stable postoperative refraction .", "sentence_id": 7}
+{"abstract_id": "26248345", "label": "conclusions", "text": "The two techniques did not show significant differences of prediction error .", "sentence_id": 8}
+{"abstract_id": "24337154", "label": "objective", "text": "Insulin-sensitive tissues ( muscle , liver ) of individuals with obesity and type @ diabetes mellitus are in a state of low-grade inflammation , characterised by increased Toll-like receptor ( TLR ) expression and TLR-driven signalling .", "sentence_id": 0}
+{"abstract_id": "24337154", "label": "objective", "text": "However , the cause of this mild inflammatory state is unclear .", "sentence_id": 1}
+{"abstract_id": "24337154", "label": "objective", "text": "We tested the hypothesis that a prolonged mild increase in plasma NEFA will increase TLR expression and TLR-driven signalling ( nuclear factor B -LSB- NFB -RSB- and mitogen-activated kinase -LSB- MAPK -RSB- ) and impair insulin action in muscle of lean healthy individuals .", "sentence_id": 2}
+{"abstract_id": "24337154", "label": "methods", "text": "Twelve lean , normal-glucose-tolerant participants were randomised to receive a @ h infusion ( @ ml/h ) of saline or Intralipid followed by a euglycaemic-hyperinsulinaemic clamp .", "sentence_id": 3}
+{"abstract_id": "24337154", "label": "methods", "text": "Vastus lateralis muscle biopsies were performed before and during the clamp .", "sentence_id": 4}
+{"abstract_id": "24337154", "label": "results", "text": "Lipid infusion impaired insulin-stimulated IRS-@ tyrosine phosphorylation and reduced peripheral insulin sensitivity ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24337154", "label": "results", "text": "The elevation in circulating NEFA increased expression of TLR@ , TLR@ and TLR@ , and several MAPK ( MAPK@ , MAP@K@ , MAP@K@ ) and inhibitor of B kinase-NFB ( CHUK -LSB- IKKA -RSB- , c-REL -LSB- REL -RSB- and p@ -LSB- RELA , NFKB@ , p@ -RSB- ) signalling genes ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24337154", "label": "results", "text": "The lipid infusion also increased extracellular signal-regulated kinase ( ERK ) phosphorylation ( p < @ ) and tended to reduce the content of inhibitor of kappa B ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24337154", "label": "results", "text": "The muscle content of most diacylglycerol , ceramide and acylcarnitine species was unaffected .", "sentence_id": 8}
+{"abstract_id": "24337154", "label": "results", "text": "In summary , insulin resistance induced by prolonged low-dose lipid infusion occurs together with increased TLR-driven inflammatory signalling and impaired insulin-stimulated IRS-@ tyrosine phosphorylation .", "sentence_id": 9}
+{"abstract_id": "24337154", "label": "conclusions", "text": "A sustained , mild elevation in plasma NEFA is sufficient to increase TLR expression and TLR-driven signalling ( NFB and MAPK ) in lean individuals .", "sentence_id": 10}
+{"abstract_id": "24337154", "label": "conclusions", "text": "The activation of this pathway by NEFA may be involved in the pathogenesis of insulin resistance in humans .", "sentence_id": 11}
+{"abstract_id": "24856939", "label": "objective", "text": "In children with cerebral palsy , does a @-month physical activity stimulation program improve physical activity , mobility capacity , fitness , fatigue and attitude towards sports more than usual paediatric physiotherapy ?", "sentence_id": 0}
+{"abstract_id": "24856939", "label": "methods", "text": "Multicentre randomised controlled trial with concealed allocation , blinded assessments and intention-to-treat analysis .", "sentence_id": 1}
+{"abstract_id": "24856939", "label": "methods", "text": "Forty-nine walking children ( @ males ) aged @-@ years with spastic cerebral palsy and severity of the disability classified as Gross Motor Function Classification System level I-III .", "sentence_id": 2}
+{"abstract_id": "24856939", "label": "methods", "text": "The intervention group followed a @-month physical activity stimulation program involving counselling through motivational interviewing , home-based physiotherapy , and @ months of fitness training .", "sentence_id": 3}
+{"abstract_id": "24856939", "label": "methods", "text": "The control group continued their usual paediatric physiotherapy .", "sentence_id": 4}
+{"abstract_id": "24856939", "label": "methods", "text": "Primary outcomes were walking activity ( assessed objectively with an activity monitor ) and parent-reported physical activity ( Activity QUESTIONnaire for Adults and Adolescents ) .", "sentence_id": 5}
+{"abstract_id": "24856939", "label": "methods", "text": "Secondary outcomes were : mobility capacity , consisting of Gross Motor Function Measure-@ ( GMFM-@ ) , walking capacity and functional strength , fitness ( aerobic and anaerobic capacity , muscle strength ) , self-reported fatigue , and attitude towards sport ( child and parent ) .", "sentence_id": 6}
+{"abstract_id": "24856939", "label": "methods", "text": "Assessments were performed at baseline , @ months , @ months and @ months .", "sentence_id": 7}
+{"abstract_id": "24856939", "label": "results", "text": "There were no significant intervention effects for physical activity or secondary outcomes at any assessment time .", "sentence_id": 8}
+{"abstract_id": "24856939", "label": "results", "text": "Positive trends were found for parent-reported time at moderate-to-vigorous intensity ( between-group change ratio = @ , @ % CI @ to @ ) and GMFM-@ ( mean between-group difference = @ points , @ % CI @ to @ ) at @ months , but not at @ months .", "sentence_id": 9}
+{"abstract_id": "24856939", "label": "results", "text": "There was a trend for a small , but clinically irrelevant , improvement in the children 's attitudes towards the disadvantages of sports at @ months , and towards the advantages of sports at @ months .", "sentence_id": 10}
+{"abstract_id": "24856939", "label": "conclusions", "text": "This physical activity stimulation program , that combined fitness training , counselling and home-based therapy , was not effective in children with cerebral palsy .", "sentence_id": 11}
+{"abstract_id": "24856939", "label": "conclusions", "text": "Further research should examine the potential of each component of the intervention for improving physical activity in this population .", "sentence_id": 12}
+{"abstract_id": "25298165", "label": "objective", "text": "To evaluate glucose-lowering treatment strategies with linagliptin and metformin in people with newly diagnosed type @ diabetes and marked hyperglycaemia , a prevalent population for which few dedicated studies of oral antidiabetes drugs have been conducted .", "sentence_id": 0}
+{"abstract_id": "25298165", "label": "methods", "text": "A total of @ patients , with type @ diabetes diagnosed for @months and with glycated haemoglobin ( HbA@c ) concentration in the range @-@ @ % , were randomized @:@ to double-blind , free-combination treatment with linagliptin @mg once daily and metformin twice daily ( uptitrated to @mg/day maximum ) or to linagliptin monotherapy .", "sentence_id": 1}
+{"abstract_id": "25298165", "label": "methods", "text": "The primary endpoint was change in HbA@c concentration from baseline at week @ ( per-protocol completers ' cohort : n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25298165", "label": "results", "text": "The mean ( standard deviation ) age and HbA@c at baseline were @ ( @ ) years and @ ( @ ) % , respectively .", "sentence_id": 3}
+{"abstract_id": "25298165", "label": "results", "text": "At week @ , the meanstandard error ( s.e. ) HbA@c decreased from baseline by -@ % with linagliptin/metformin and -@ % with linagliptin ; a treatment difference of -@ % ( @ % confidence interval -@ to -@ ; p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25298165", "label": "results", "text": "Similar results were observed in a sensitivity analysis based on intent-to-treat principles : adjusted means.e .", "sentence_id": 5}
+{"abstract_id": "25298165", "label": "results", "text": "changes in HbA@c of -@ % and -@ % , respectively ; treatment difference of -@ % ( @ % CI -@ to -@ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25298165", "label": "results", "text": "A treatment response of HbA@c < @ % was achieved by @ and @ % of patients in the linagliptin/metformin and linagliptin groups , respectively .", "sentence_id": 7}
+{"abstract_id": "25298165", "label": "results", "text": "Few patients experienced drug-related adverse events ( @ and @ % of patients in the linagliptin/metformin and linagliptin groups , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25298165", "label": "results", "text": "Hypoglycaemia occurred in @ and @ % of patients in the linagliptin/metformin and linagliptin groups , respectively ( no severe episodes ) .", "sentence_id": 9}
+{"abstract_id": "25298165", "label": "results", "text": "Body weight decreased significantly with the combination therapy ( -@ kg between-group difference ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25298165", "label": "conclusions", "text": "Linagliptin in initial combination with metformin in patients with newly diagnosed type @ diabetes and marked hyperglycaemia , an understudied group , elicited significant improvements in glycaemic control with a low incidence of hypoglycaemia , weight gain or other adverse effects .", "sentence_id": 11}
+{"abstract_id": "25298165", "label": "conclusions", "text": "These results support early combination treatment strategies and suggest that newly diagnosed patients with marked hyperglycaemia may be effectively managed with oral , non-insulin therapy .", "sentence_id": 12}
+{"abstract_id": "24269603", "label": "objective", "text": "To assess post-operative pain in patients who underwent arthroscopic anterior cruciate ligament ( ACL ) reconstruction by the all-inside technique .", "sentence_id": 0}
+{"abstract_id": "24269603", "label": "methods", "text": "A prospective randomized comparative parallel trial was performed in @-@ including all patients who underwent an ACL reconstruction in an orthopaedic department in accordance with the CONSORT statement @ .", "sentence_id": 1}
+{"abstract_id": "24269603", "label": "methods", "text": "Patients were randomized to the surgical procedure , all-inside or classical , and were blinded to the surgical technique .", "sentence_id": 2}
+{"abstract_id": "24269603", "label": "methods", "text": "Primary evaluation criterion was pain assessed on the Visual Analogical Scale @ month after surgery .", "sentence_id": 3}
+{"abstract_id": "24269603", "label": "methods", "text": "Secondary parameters were analgesic consumption , tunnel positioning on X-ray according to Aglietti 's criteria and functional evaluation at six months with IKDC score .", "sentence_id": 4}
+{"abstract_id": "24269603", "label": "methods", "text": "None of the patients was lost to follow-up .", "sentence_id": 5}
+{"abstract_id": "24269603", "label": "results", "text": "@ consecutive patients were included , @ in each group , mean age @ years .", "sentence_id": 6}
+{"abstract_id": "24269603", "label": "results", "text": "Two patients were excluded due to postoperative complications that required early revision surgery .", "sentence_id": 7}
+{"abstract_id": "24269603", "label": "results", "text": "Forty-four patients were analyzed , @ in each group .", "sentence_id": 8}
+{"abstract_id": "24269603", "label": "results", "text": "At one month , the pain level was @ for the all-inside group and @ for the classical group , p = @ ( @ % CI @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "24269603", "label": "results", "text": "Postoperative analgesic consumption was similar .", "sentence_id": 10}
+{"abstract_id": "24269603", "label": "results", "text": "The position of the tibial tunnels was better with the all-inside method , p = @ ( @ % CI @-@ @ % ) .", "sentence_id": 11}
+{"abstract_id": "24269603", "label": "results", "text": "There was no significant difference in the mean IKDC subjective score at six months , p = @ ( @ % CI-@ @ to @ ) .", "sentence_id": 12}
+{"abstract_id": "24269603", "label": "conclusions", "text": "At one month , the pain level seemed lower in the all-inside group than in the classical group , at the limit of statistical significance because the study was underpowered .", "sentence_id": 13}
+{"abstract_id": "24269603", "label": "conclusions", "text": "The all-inside technique is a reliable procedure with very good results for pain , stability and knee function .", "sentence_id": 14}
+{"abstract_id": "24269603", "label": "methods", "text": "I ; Therapeutic study .", "sentence_id": 15}
+{"abstract_id": "24927436", "label": "objective", "text": "To evaluate the effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria among preterm infants in the neonatal intensive care unit ( NICU ) .", "sentence_id": 0}
+{"abstract_id": "24927436", "label": "methods", "text": "A double-blind , randomized , placebo-controlled trial was carried out in the preterm infants who were transferred to the NICU immediately after birth .", "sentence_id": 1}
+{"abstract_id": "24927436", "label": "methods", "text": "These infants were stratified by whether they were breastfed and then randomized into test group and control group .", "sentence_id": 2}
+{"abstract_id": "24927436", "label": "methods", "text": "The test group was given probiotics from the day when enteral feeding began , while the control group was treated conventionally without probiotics .", "sentence_id": 3}
+{"abstract_id": "24927436", "label": "methods", "text": "The two groups were compared in terms of the colonization with extended-spectrum beta-lactamase-producing bacteria , as assessed by rectal swabs on days @ , @ , @ , and @ after birth , and the incidence of diseases .", "sentence_id": 4}
+{"abstract_id": "24927436", "label": "results", "text": "Rectal colonization with drug-resistant bacteria was found in the test group ( n = @ ) and control group ( n = @ ) on days @ , @ , @ , and @ after birth .", "sentence_id": 5}
+{"abstract_id": "24927436", "label": "results", "text": "There were no significant differences in the incidence of late-onset sepsis and necrotizing enterocolitis between the two groups ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24927436", "label": "results", "text": "Among non-breastfed infants , the test group had significantly decreased rectal colonization with drug-resistant bacteria compared with the control group on day @ after birth ( @ % vs @ % ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24927436", "label": "results", "text": "No probiotic-related adverse events were observed in the study .", "sentence_id": 8}
+{"abstract_id": "24927436", "label": "conclusions", "text": "Oral administration of probiotics may reduce rectal colonization with drug-resistant bacteria in preterm infants under certain conditions and shows good safety .", "sentence_id": 9}
+{"abstract_id": "25286173", "label": "objective", "text": "The clinical benefit of adding a macrolide to a - lactam for empirical treatment of moderately severe community-acquired pneumonia remains controversial .", "sentence_id": 0}
+{"abstract_id": "25286173", "label": "objective", "text": "To test noninferiority of a - lactam alone compared with a - lactam and macrolide combination in moderately severe community-acquired pneumonia .", "sentence_id": 1}
+{"abstract_id": "25286173", "label": "methods", "text": "Open-label , multicenter , noninferiority , randomized trial conducted from January @ , @ , through January @ , @ , in @ immunocompetent adult patients hospitalized in @ acute care hospitals in Switzerland for moderately severe community-acquired pneumonia .", "sentence_id": 2}
+{"abstract_id": "25286173", "label": "methods", "text": "Follow-up extended to @ days .", "sentence_id": 3}
+{"abstract_id": "25286173", "label": "methods", "text": "Outcome assessors were masked to treatment allocation .", "sentence_id": 4}
+{"abstract_id": "25286173", "label": "methods", "text": "Patients were treated with a - lactam and a macrolide ( combination arm ) or with a - lactam alone ( monotherapy arm ) .", "sentence_id": 5}
+{"abstract_id": "25286173", "label": "methods", "text": "Legionella pneumophila infection was systematically searched and treated by addition of a macrolide to the monotherapy arm .", "sentence_id": 6}
+{"abstract_id": "25286173", "label": "methods", "text": "Proportion of patients not reaching clinical stability ( heart rate < @/min , systolic blood pressure > @ mm Hg , temperature < @ C , respiratory rate < @/min , and oxygen saturation > @ % on room air ) at day @ .", "sentence_id": 7}
+{"abstract_id": "25286173", "label": "results", "text": "After @ days of treatment , @ of @ patients ( @ % ) in the monotherapy arm vs @ of @ ( @ % ) in the combination arm had not reached clinical stability ( @ % difference , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25286173", "label": "results", "text": "The upper limit of the @-sided @ % CI was @ % , exceeding the predefined noninferiority boundary of @ % .", "sentence_id": 9}
+{"abstract_id": "25286173", "label": "results", "text": "Patients infected with atypical pathogens ( hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @-@ @ ) or with Pneumonia Severity Index ( PSI ) category IV pneumonia ( HR , @ ; @ % CI , @-@ @ ) were less likely to reach clinical stability with monotherapy , whereas patients not infected with atypical pathogens ( HR , @ ; @ % CI , @-@ @ ) or with PSI category I to III pneumonia ( HR , @ ; @ % CI , @-@ @ ) had equivalent outcomes in the @ arms .", "sentence_id": 10}
+{"abstract_id": "25286173", "label": "results", "text": "There were more @-day readmissions in the monotherapy arm ( @ % vs @ % , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25286173", "label": "results", "text": "Mortality , intensive care unit admission , complications , length of stay , and recurrence of pneumonia within @ days did not differ between the @ arms .", "sentence_id": 12}
+{"abstract_id": "25286173", "label": "conclusions", "text": "We did not find noninferiority of - lactam monotherapy in patients hospitalized for moderately severe community-acquired pneumonia .", "sentence_id": 13}
+{"abstract_id": "25286173", "label": "conclusions", "text": "Patients infected with atypical pathogens or with PSI category IV pneumonia had delayed clinical stability with monotherapy .", "sentence_id": 14}
+{"abstract_id": "24966672", "label": "background", "text": "Olodaterol is a long-acting @-agonist with a @-hour bronchodilator profile .", "sentence_id": 0}
+{"abstract_id": "24966672", "label": "background", "text": "Two replicate , randomized , double-blind , placebo-controlled , parallel-group , Phase III trials were performed as part of a comprehensive clinical program to investigate the long-term safety and efficacy of olodaterol in patients with moderate to very severe chronic obstructive pulmonary disease ( COPD ) receiving usual-care background therapy .", "sentence_id": 1}
+{"abstract_id": "24966672", "label": "methods", "text": "Patients received olodaterol @ g or @ g or placebo once daily for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24966672", "label": "methods", "text": "Coprimary end points were forced expiratory volume in @ second ( FEV@ ) area under the curve from @ to @ hours ( AUC@-@ ) response ( change from baseline ) , and trough FEV@ response at @ weeks .", "sentence_id": 3}
+{"abstract_id": "24966672", "label": "methods", "text": "Secondary end points included additional lung function assessments , use of rescue medications , FEV@ AUC response from @ to @ hours , and Patient Global Rating over @ weeks .", "sentence_id": 4}
+{"abstract_id": "24966672", "label": "results", "text": "Overall , @ and @ patients were evaluated in studies @ and @ , respectively .", "sentence_id": 5}
+{"abstract_id": "24966672", "label": "results", "text": "In both studies , olodaterol @ g and @ g significantly improved the FEV@ AUC@-@ response ( P < @ ) and trough FEV@ ( study @ , P < @ ; study @ , P < @ , post hoc ) at week @ , with an incidence of adverse events comparable with that of placebo .", "sentence_id": 6}
+{"abstract_id": "24966672", "label": "results", "text": "Secondary end points supported the efficacy of olodaterol .", "sentence_id": 7}
+{"abstract_id": "24966672", "label": "conclusions", "text": "These studies demonstrate the long-term efficacy and safety of once-daily olodaterol @ g and @ g in patients with moderate to very severe COPD continuing with usual-care maintenance therapy .", "sentence_id": 8}
+{"abstract_id": "25300706", "label": "objective", "text": "WARCEF randomized @,@ patients in sinus rhythm with ejection fraction ( EF ) @ % to warfarin ( INR @-@ @ ) or aspirin @ mg .", "sentence_id": 0}
+{"abstract_id": "25300706", "label": "objective", "text": "Warfarin reduced the incident ischemic stroke ( IIS ) hazard rate by @ % over aspirin in a secondary analysis .", "sentence_id": 1}
+{"abstract_id": "25300706", "label": "objective", "text": "The IIS rate in heart failure ( HF ) is too low to warrant routine anticoagulation but epidemiologic studies show that prior stroke increases the stroke risk in HF .", "sentence_id": 2}
+{"abstract_id": "25300706", "label": "objective", "text": "In this study , we explore IIS rates in WARCEF patients with and without baseline stroke to look for risk factors for IIS and determine if a subgroup with an IIS rate high enough to give a clinically relevant stroke risk reduction can be identified .", "sentence_id": 3}
+{"abstract_id": "25300706", "label": "methods", "text": "We compared potential stroke risk factors between patients with baseline stroke and those without using the exact conditional score test for Poisson variables .", "sentence_id": 4}
+{"abstract_id": "25300706", "label": "methods", "text": "We looked for risk factors for IIS , by comparing IIS rates between different risk factors .", "sentence_id": 5}
+{"abstract_id": "25300706", "label": "methods", "text": "For EF we tried cut-off points of @ , @ and @ % .", "sentence_id": 6}
+{"abstract_id": "25300706", "label": "methods", "text": "The cut-off point @ % was used as it was the highest EF that was associated with a significant increase in IIS rate .", "sentence_id": 7}
+{"abstract_id": "25300706", "label": "methods", "text": "IIS and EF strata were balanced as to warfarin/aspirin assignment by the stratified randomized design .", "sentence_id": 8}
+{"abstract_id": "25300706", "label": "methods", "text": "A multiple Poisson regression examined the simultaneous effects of all risk factors on IIS rate .", "sentence_id": 9}
+{"abstract_id": "25300706", "label": "methods", "text": "IIS rates per hundred patient years ( / @ PY ) were calculated in patient groups with significant risk factors .", "sentence_id": 10}
+{"abstract_id": "25300706", "label": "methods", "text": "Missing values were assigned the modal value .", "sentence_id": 11}
+{"abstract_id": "25300706", "label": "results", "text": "Twenty of @ ( @ % ) patients with baseline stroke and @ of @,@ ( @ % ) without had IIS .", "sentence_id": 12}
+{"abstract_id": "25300706", "label": "results", "text": "IIS rate in patients with baseline stroke ( @ / @ PY ) was greater than patients without ( @ / @ PY ) ( rate ratio @ , p < @ ) .", "sentence_id": 13}
+{"abstract_id": "25300706", "label": "results", "text": "Fourteen of @ ( @ % ) patients with ejection fraction ( EF ) < @ % and @ of @,@ ( @ % ) with EF @ % had IIS .", "sentence_id": 14}
+{"abstract_id": "25300706", "label": "results", "text": "In the multiple regression analysis stroke at baseline ( p < @ ) and EF < @ % vs. @ % ( p = @ ) remained significant predictors of IIS .", "sentence_id": 15}
+{"abstract_id": "25300706", "label": "results", "text": "IIS rate was @ / @ PY in patients with EF < @ % and @ / @ PY in patients with EF @ % ( p = @ ) .", "sentence_id": 16}
+{"abstract_id": "25300706", "label": "results", "text": "IIS rate in patients with baseline stroke and reduced EF was @ / @ PY with EF < @ % decreasing to @ / @ PY with EF < @ % .", "sentence_id": 17}
+{"abstract_id": "25300706", "label": "conclusions", "text": "In a WARCEF exploratory analysis , prior stroke and EF < @ % were risk factors for IIS .", "sentence_id": 18}
+{"abstract_id": "25300706", "label": "conclusions", "text": "Further research is needed to determine if a clinically relevant stroke risk reduction is obtainable with warfarin in HF patients with prior stroke and reduced EF .", "sentence_id": 19}
+{"abstract_id": "24219891", "label": "objective", "text": "High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders .", "sentence_id": 0}
+{"abstract_id": "24219891", "label": "objective", "text": "Especially , high-fructose intake is regarded as potentially harmful to cardiometabolic health .", "sentence_id": 1}
+{"abstract_id": "24219891", "label": "objective", "text": "It may cause not only weight gain but also low-grade inflammation , which represents an independent risk factor for developing type @ diabetes and cardiovascular disease .", "sentence_id": 2}
+{"abstract_id": "24219891", "label": "objective", "text": "In particular , fructose has been suggested to induce plasminogen activator inhibitor-@ ( PAI-@ ) expression in the liver and to increase circulating inflammatory cytokines .", "sentence_id": 3}
+{"abstract_id": "24219891", "label": "objective", "text": "We therefore aimed to investigate , whether high-fructose diet has an impact on PAI-@ , monocyte chemoattractant protein-@ ( MCP-@ ) , e-selectin and C-reactive protein ( CRP ) concentrations in healthy humans .", "sentence_id": 4}
+{"abstract_id": "24219891", "label": "methods", "text": "We studied @ participants ( @ males and @ females ) of the TUebingen FRuctose Or Glucose study .", "sentence_id": 5}
+{"abstract_id": "24219891", "label": "methods", "text": "This is an exploratory , parallel , prospective , randomized , single-blinded , outpatient , hypercaloric , intervention study .", "sentence_id": 6}
+{"abstract_id": "24219891", "label": "methods", "text": "The participants had a mean age of @ @ years and a mean body mass index of @ @ kg/m ( @ ) and they received @ g of either fructose or glucose per day for @ weeks .", "sentence_id": 7}
+{"abstract_id": "24219891", "label": "results", "text": "There were neither significant changes of PAI-@ , MCP-@ , e-selectin and CRP after fructose ( n = @ ) and glucose ( n = @ ) intervention nor treatment effects ( all P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24219891", "label": "results", "text": "Moreover , we did not observe longitudinal associations of the inflammatory parameters with triglycerides , liver fat , visceral fat and body weight in the fructose group .", "sentence_id": 9}
+{"abstract_id": "24219891", "label": "conclusions", "text": "Temporary high-fructose intake does not seem to cause inflammation in apparently healthy people in this secondary analysis of a small feeding trial .", "sentence_id": 10}
+{"abstract_id": "24502959", "label": "background", "text": "Studies have demonstrated that plasmakinetic enucleation of the prostate ( PKEP ) and open prostatectomy ( OP ) have equivalent short-term efficacy for large prostates , but no comparison concerning their long-term results was reported .", "sentence_id": 0}
+{"abstract_id": "24502959", "label": "objective", "text": "To demonstrate the noninferiority of PKEP to OP concerning maximum urinary flow rate ( Qmax ) at @ yr postoperatively and to compare the long-term results of both procedures .", "sentence_id": 1}
+{"abstract_id": "24502959", "label": "methods", "text": "From @ to @ , @ patients with prostates > @g were randomized to receive PKEP or OP .", "sentence_id": 2}
+{"abstract_id": "24502959", "label": "methods", "text": "A total of @ patients ( @ % ) completed the noninferiority study , and @ patients ( @ % ) finished a @-yr follow-up assessment .", "sentence_id": 3}
+{"abstract_id": "24502959", "label": "methods", "text": "The PKEP procedures were performed with @F Karl Storz continuous flow resectoscopy and the Gyrus PlasmaKinetic device .", "sentence_id": 4}
+{"abstract_id": "24502959", "label": "methods", "text": "OP was performed by a suprapubic transvesical approach .", "sentence_id": 5}
+{"abstract_id": "24502959", "label": "methods", "text": "The primary end point was Qmax at @ yr postoperatively .", "sentence_id": 6}
+{"abstract_id": "24502959", "label": "methods", "text": "Secondary end points included other perioperative parameters and postoperative micturition variables .", "sentence_id": 7}
+{"abstract_id": "24502959", "label": "methods", "text": "The student t test , Mann-Whitney U test , chi-square test , or Fisher exact probability test was used as appropriate .", "sentence_id": 8}
+{"abstract_id": "24502959", "label": "conclusions", "text": "PKEP was noninferior to OP regarding Qmax at @ yr postoperatively .", "sentence_id": 9}
+{"abstract_id": "24502959", "label": "conclusions", "text": "Compared with OP , PKEP was associated with less perioperative hemoglobin decrease , shorter catheterization time , and shorter postoperative hospital stay ( @ vs @ g/dl , @ vs @h , and @ vs @ d , respectively ; p < @ for all ) , as well as fewer short-term complications ( @ % vs @ % , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24502959", "label": "conclusions", "text": "On intention-to-treat analysis , both the PKEP and OP groups had equivalent Qmax ( @ ml/s vs @ ml/s , respectively ; p = @ ) , International Prostate Symptom Score ( @ -LSB- @-@ -RSB- vs @ -LSB- @-@ -RSB- , respectively p = @ ) , quality of life ( @ -LSB- @-@ -RSB- vs @ -LSB- @-@ -RSB- , respectively ; p = @ ) , and postvoid residual urine ( @ -LSB- @-@ @ -RSB- vs @ -LSB- @-@ -RSB- ml , respectively ; p = @ ) at @ mo postoperatively .", "sentence_id": 11}
+{"abstract_id": "24502959", "label": "conclusions", "text": "No patients required reoperation because of recurrence of BPH .", "sentence_id": 12}
+{"abstract_id": "24502959", "label": "conclusions", "text": "The relatively small sample size is the limitation .", "sentence_id": 13}
+{"abstract_id": "24502959", "label": "conclusions", "text": "PKEP is a durable procedure with short - to long-term micturition improvement equivalent to OP and significantly lower perioperative morbidity .", "sentence_id": 14}
+{"abstract_id": "24502959", "label": "results", "text": "We compared PKEP with OP for large prostates and found that PKEP is less invasive , with short - to long-term micturition improvement equivalent to OP .", "sentence_id": 15}
+{"abstract_id": "25414152", "label": "objective", "text": "To evaluate whether treatment of mild gestational diabetes mellitus ( GDM ) confers sustained offspring health benefits , including a lower frequency of obesity .", "sentence_id": 0}
+{"abstract_id": "25414152", "label": "methods", "text": "Follow-up study of children ( ages @-@ ) of women enrolled in a multicenter trial of treatment versus no treatment of mild GDM .", "sentence_id": 1}
+{"abstract_id": "25414152", "label": "methods", "text": "Height , weight , blood pressure , waist circumference , fasting glucose , fasting insulin , triglycerides , and HDL cholesterol were measured .", "sentence_id": 2}
+{"abstract_id": "25414152", "label": "results", "text": "Five hundred of @ eligible offspring ( @ % ) were enrolled .", "sentence_id": 3}
+{"abstract_id": "25414152", "label": "results", "text": "Maternal baseline characteristics were similar between the follow-up treated and untreated groups .", "sentence_id": 4}
+{"abstract_id": "25414152", "label": "results", "text": "The frequencies of BMI @th ( @ % and @ % ) and @th ( @ % and @ % ) percentiles were not significantly different in treated versus untreated offspring ( P = @ and P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25414152", "label": "results", "text": "No associations were observed for BMI z score , log waist circumference , log triglycerides , HDL cholesterol , blood pressure , or log HOMA-estimated insulin resistance ( HOMA-IR ) .", "sentence_id": 6}
+{"abstract_id": "25414152", "label": "results", "text": "The effect of treatment was different by sex for fasting glucose and log HOMA-IR ( P for interaction = @ and @ , respectively ) but not by age-group ( @-@ and @-@ years ) for any outcomes .", "sentence_id": 7}
+{"abstract_id": "25414152", "label": "results", "text": "Female offspring of treated women had significantly lower fasting glucose levels .", "sentence_id": 8}
+{"abstract_id": "25414152", "label": "conclusions", "text": "Although treatment for mild GDM has been associated with neonatal benefits , no reduction in childhood obesity or metabolic dysfunction in the offspring of treated women was found .", "sentence_id": 9}
+{"abstract_id": "25414152", "label": "conclusions", "text": "However , only female offspring of women treated for mild GDM had lower fasting glucose .", "sentence_id": 10}
+{"abstract_id": "25703320", "label": "objective", "text": "To evaluate the long-term effects of an illicit drug use prevention program for adolescents that integrates life skills into the theory of planned behavior .", "sentence_id": 0}
+{"abstract_id": "25703320", "label": "methods", "text": "We conducted a cluster-randomized trial in which @ participating schools were randomized to either an intervention group ( @ schools , n = @,@ students ) or a control group ( @schools , n = @ students ) .", "sentence_id": 1}
+{"abstract_id": "25703320", "label": "methods", "text": "Participants were grade @ students .", "sentence_id": 2}
+{"abstract_id": "25703320", "label": "methods", "text": "The intervention comprised a main intervention of @ sessions and two booster interventions .", "sentence_id": 3}
+{"abstract_id": "25703320", "label": "methods", "text": "Booster @ ( four sessions ) and booster @ ( two sessions ) were performed at @months and @months , respectively , after completion of the main intervention .", "sentence_id": 4}
+{"abstract_id": "25703320", "label": "methods", "text": "Assessments were made at baseline , after the main intervention , and after each booster session using specific questionnaires for measuring participants ' attitudes , subjective norms , perceived behavioral control , and life skills .", "sentence_id": 5}
+{"abstract_id": "25703320", "label": "results", "text": "Retention rates were @ % ( @/@ ,@ ) in the intervention group and @ % ( @/@ ) in the control group after the @-month follow-up .", "sentence_id": 6}
+{"abstract_id": "25703320", "label": "results", "text": "A significantly lower proportion of intervention group participants reported illicit drug use after the first and second booster sessions compared with control group participants ( @ % vs. @ % and @ % vs. @ % , respectively ; both p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25703320", "label": "results", "text": "Attitudes , subjective norms , perceived behavioral control , life skills , and behavioral intention scores of theintervention group were significantly higher than those of control group after the first and second booster sessions ( all p < @ ) , suggesting that intervention group students tended to avoid drug use .", "sentence_id": 8}
+{"abstract_id": "25703320", "label": "conclusions", "text": "A drug use prevention program integrating life skills into the theory of planned behavior may be effective for reducing illicit drug use and improving planned behavior-related constructs in adolescents .", "sentence_id": 9}
+{"abstract_id": "26054142", "label": "objective", "text": "To compare the difference of the clinical efficacy in treatment of nervous tinnitus of kidney deficiency between the combined therapy of Zhuang medicine at Qineihuan point combined with the conventional acupuncture and simple conventional acupancture .", "sentence_id": 0}
+{"abstract_id": "26054142", "label": "methods", "text": "Sixty patients were randomized into an observation group and a control group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "26054142", "label": "methods", "text": "In the control group , the conventional acupuncture was applied to Taixi ( KI @ ) , Zhaohai ( KI @ ) , Tinggong ( SI @ ) and Waiguan ( TE @ ) , etc. and the needles were retained for @ min .", "sentence_id": 2}
+{"abstract_id": "26054142", "label": "methods", "text": "In the observation group , on the basic treatment as the control group , Zhuang medicine acupuncture at Qineihuan point was added .", "sentence_id": 3}
+{"abstract_id": "26054142", "label": "methods", "text": "The treatment was given once every day , @ treatments made one session and there were @ days of interval between the sessions .", "sentence_id": 4}
+{"abstract_id": "26054142", "label": "methods", "text": "In @ sessions of treatment , the changes of tinnitus were observed and the clinical efficacy was evaluated .", "sentence_id": 5}
+{"abstract_id": "26054142", "label": "results", "text": "After treatment , tinnitus score and tinnitus grade were all improved as compared with those before treatment in the two groups ( all P < @ ) and the results in the observation group were better than those in the control group ( all P < @ ) .", "sentence_id": 6}
+{"abstract_id": "26054142", "label": "results", "text": "The curative and remarkably effective rate was @ % ( @/@ ) and the total effective rate was @ % ( @/@ ) in the observation group , better than @ % ( @/@ ) and @ % ( @/@ ) in the control group ( both P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26054142", "label": "conclusions", "text": "The combined therapy of Zhuang medicine at Qineihuan point and conventional acupuncture achieves the better efficacy on nervous tinnitus of kidney deficiency as compared with the simple conventional acupuncture .", "sentence_id": 8}
+{"abstract_id": "25319385", "label": "objective", "text": "Presepsin is a soluble fragment of the cluster-of-differentiation marker protein @ ( CD@ ) involved in pathogen recognition by innate immunity .", "sentence_id": 0}
+{"abstract_id": "25319385", "label": "objective", "text": "We evaluated the relation between its circulating concentration , host response , appropriateness of antibiotic therapy , and mortality in patients with severe sepsis .", "sentence_id": 1}
+{"abstract_id": "25319385", "label": "methods", "text": "Plasma presepsin was measured @ , @ , and @ days after enrollment of @ patients with severe sepsis or septic shock in the multicenter Albumin Italian Outcome Sepsis ( ALBIOS ) trial .", "sentence_id": 2}
+{"abstract_id": "25319385", "label": "methods", "text": "They were randomized to albumin or crystalloids .", "sentence_id": 3}
+{"abstract_id": "25319385", "label": "methods", "text": "We tested with univariate and adjusted models the association of single measurements of presepsin or changes over time with clinical events , organ dysfunctions , appropriateness of antibiotic therapy , and ICU or @-day mortality .", "sentence_id": 4}
+{"abstract_id": "25319385", "label": "results", "text": "Presepsin concentration at baseline ( @ -LSB- @-@ ,@ -RSB- ng/L ) increased with the SOFA score , the number of prevalent organ dysfunctions or failures , and the incidence of new failures of the respiratory , coagulation , liver , and kidney systems .", "sentence_id": 5}
+{"abstract_id": "25319385", "label": "results", "text": "The concentration decreased in ICU over @ days in patients with negative blood cultures , and in those with positive blood cultures and appropriate antibiotic therapy ; it increased with inappropriate antibiotic therapy ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25319385", "label": "results", "text": "Baseline presepsin was independently associated with , and correctly reclassified , the risk of ICU and @-day mortality .", "sentence_id": 7}
+{"abstract_id": "25319385", "label": "results", "text": "Increasing concentrations of presepsin from day @ to day @ predicted higher ICU and @-day mortality ( adjusted p < @ and @ , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25319385", "label": "results", "text": "Albumin had no effect on presepsin concentration .", "sentence_id": 9}
+{"abstract_id": "25319385", "label": "conclusions", "text": "Presepsin is an early predictor of host response and mortality in septic patients .", "sentence_id": 10}
+{"abstract_id": "25319385", "label": "conclusions", "text": "Changes in concentrations over time seem to reflect the appropriateness of antibiotic therapy .", "sentence_id": 11}
+{"abstract_id": "24507830", "label": "background", "text": "The methacholine challenge test quantifies airway hyper-responsiveness , which is measured by the provocative concentration of methacholine causing a @ % decrease in forced expiration volume in @ second ( PC@ ) .", "sentence_id": 0}
+{"abstract_id": "24507830", "label": "background", "text": "The dose-response effect of inhaled corticosteroids ( ICS ) on PC@ has been inconsistent and within-patient variability of PC@ is not well established .", "sentence_id": 1}
+{"abstract_id": "24507830", "label": "objective", "text": "To determine the effect of high - vs low-dose ICS on PC@ and within-patient variability in those with repeated measurements of PC@ .", "sentence_id": 2}
+{"abstract_id": "24507830", "label": "methods", "text": "A randomized , double-masked , crossover trial was conducted in patients with asthma on controller medications with PC@ of @ mg/mL or lower ( n = @ ) to evaluate the effect of high-dose ( @,@ g/d ) vs low-dose ( @ g/d ) fluticasone for @ weeks on PC@ .", "sentence_id": 3}
+{"abstract_id": "24507830", "label": "methods", "text": "In addition , the variability of PC@ was assessed in participants who underwent @ or @ PC@ measurements on the same dose of ICS ( n = @ ) over a @-week interval .", "sentence_id": 4}
+{"abstract_id": "24507830", "label": "results", "text": "Because there was a significant period effect , dose comparison of the change in PC@ was assessed in the first treatment period .", "sentence_id": 5}
+{"abstract_id": "24507830", "label": "results", "text": "There was no significant difference in the change in PC@ for high - vs low-dose ICS ( @ % vs @ % increase , respectively ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24507830", "label": "results", "text": "The within - and between-participant variances for log PC@ were @ and @ , respectively , with an intra-class correlation of @ , and @ % of participants had more than @ doubling dose changes in PC@ in those with repeated measurements .", "sentence_id": 7}
+{"abstract_id": "24507830", "label": "conclusions", "text": "The effect of ICS on PC@ is not dose dependent at fluticasone levels of @ and @,@ g/d .", "sentence_id": 8}
+{"abstract_id": "24507830", "label": "conclusions", "text": "Interpersonal variability for PC@ is large .", "sentence_id": 9}
+{"abstract_id": "24507830", "label": "conclusions", "text": "A lack of precise measurements should be taken into account when interpreting any change in PC@ .", "sentence_id": 10}
+{"abstract_id": "24976433", "label": "objective", "text": "Selenium supplementation for women infected with HIV may increase genital shedding of HIV-@ , however , to our knowledge , no studies have examined the effect on viral shedding in breast milk .", "sentence_id": 0}
+{"abstract_id": "24976433", "label": "objective", "text": "The aim of this study was to determine the effect of selenium supplementation on HIV-@ RNA detection in breast milk of HIV-infected women .", "sentence_id": 1}
+{"abstract_id": "24976433", "label": "methods", "text": "HIV-infected pregnant women enrolled at @ to @ wk gestation in a randomized , double-blind , placebo-controlled trial of daily selenium ( @ g as selenomethionine ) had cell-free HIV-@ RNA quantified in breast milk at @ to @ wk postpartum .", "sentence_id": 2}
+{"abstract_id": "24976433", "label": "methods", "text": "All participants received high-dose multivitamins containing vitamin B complex , C , and E as standard of care .", "sentence_id": 3}
+{"abstract_id": "24976433", "label": "results", "text": "The proportion of women with detectable ( > @ copies/mL ) HIV-@ RNA in breast milk appeared to be increased in the selenium group ( @ % ) compared with those in the placebo group ( @ % ) among the total cohort ( N = @ ) , but results were borderline statistically significant ( relative risk -LSB- RR -RSB- , @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24976433", "label": "results", "text": "In secondary analyses , the proportion of women with detectable HIV-@ RNA in breast milk was significantly greater in the selenium group ( @ % ) compared with placebo group ( @ % ) among women who did not receive highly active antiretroviral therapy ( HAART ; RR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24976433", "label": "results", "text": "This relationship was primarily due to a significant effect of selenium among primiparous women ( RR , @ ; @ % CI , @-@ @ ; P < @ ) , but not multiparous women ( RR , @ ; @ % CI , @-@ @ ; P = @ ) ( P-value for interaction = @ ) .", "sentence_id": 6}
+{"abstract_id": "24976433", "label": "results", "text": "Too few women received HAART in this study ( n = @ ) to establish the effect of selenium supplementation .", "sentence_id": 7}
+{"abstract_id": "24976433", "label": "conclusions", "text": "Selenium supplementation appears to increase HIV-@ RNA detection in breast milk among primiparous women not receiving HAART .", "sentence_id": 8}
+{"abstract_id": "24976433", "label": "conclusions", "text": "Safety studies among pregnant women on HAART need to be conducted before administering selenium-containing supplements .", "sentence_id": 9}
+{"abstract_id": "25249415", "label": "background", "text": "Published studies have reported conflicting results regarding the effects of cinnamon on glucose , lipids and insulin .", "sentence_id": 0}
+{"abstract_id": "25249415", "label": "background", "text": "To gain further insight into the metabolic effects of Cinnamomum cassia we performed randomized , double-blinded placebo-controlled study using euglycaemic-hyperinsulinaemic clamp .", "sentence_id": 1}
+{"abstract_id": "25249415", "label": "methods", "text": "Twenty-one subjects with impaired glucose tolerance ( IGT ) were included in the study ( @ or @ subjects in each group ) .", "sentence_id": 2}
+{"abstract_id": "25249415", "label": "methods", "text": "The study groups were matched for age , gender and body mass index ( BMI ) .", "sentence_id": 3}
+{"abstract_id": "25249415", "label": "methods", "text": "Waist-to-hip ratio , BMI , blood pressure , fasting blood glucose , insulin , triglycerides , total cholesterol , low-density lipoprotein , high-density lipoprotein , HbA@c , ASAT , ALAT , bilirubin , ALP , GT and PK were measured before and after the intake of capsules equivalent to @ g cinnamon twice a day for @ weeks .", "sentence_id": 4}
+{"abstract_id": "25249415", "label": "methods", "text": "The changes in insulin resistance were measured by euglycaemic-hyperinsulinaemic clamp .", "sentence_id": 5}
+{"abstract_id": "25249415", "label": "methods", "text": "The Wilcoxon signed rank sum test , the Mann-Whitney U test and Pearson 's chi-squared test were used to analyse the data .", "sentence_id": 6}
+{"abstract_id": "25249415", "label": "methods", "text": "Values of p < @ were considered to indicate statistically significant differences .", "sentence_id": 7}
+{"abstract_id": "25249415", "label": "results", "text": "At enrolment , the groups were similar in terms of age , gender and BMI .", "sentence_id": 8}
+{"abstract_id": "25249415", "label": "results", "text": "Of the @ randomized patients with IGT , @ completed the study ( @ controls vs. @ treated ) .", "sentence_id": 9}
+{"abstract_id": "25249415", "label": "results", "text": "The ingestion of @ g cinnamon twice a day for @ weeks had no significant effect on insulin sensitivity , HbA@c , fasting glucose or BMI .", "sentence_id": 10}
+{"abstract_id": "25249415", "label": "results", "text": "No significant changes were seen in lipids or liver enzymes .", "sentence_id": 11}
+{"abstract_id": "25249415", "label": "conclusions", "text": "This study showed that ingestion of @ g C. cassia twice a day for @ weeks did not change the insulin sensitivity or liver enzymes in subjects with IGT .", "sentence_id": 12}
+{"abstract_id": "24443982", "label": "background", "text": "Up to @ % of patients suffer from long-term functional restrictions following conservative treatment of distal radius fractures .", "sentence_id": 0}
+{"abstract_id": "24443982", "label": "background", "text": "Whether duration of cast immobilisation influences functional outcome remains unclear .", "sentence_id": 1}
+{"abstract_id": "24443982", "label": "methods", "text": "The aim of the study is to evaluate whether the duration of immobilization of non or minimally displaced distal radial fractures can be safely reduced .", "sentence_id": 2}
+{"abstract_id": "24443982", "label": "methods", "text": "We will compare three weeks of plaster cast immobilization with five weeks of plaster cast immobilization in adult patient with non or minimally displaced distal radial fractures .", "sentence_id": 3}
+{"abstract_id": "24443982", "label": "methods", "text": "a prospective randomized clinical trial .", "sentence_id": 4}
+{"abstract_id": "24443982", "label": "methods", "text": "adult ( > @ years ) ( independent in activities of daily living ) patients with a non/minimal displaced distal radius fracture ( dorsal angulation < @ , volar tilt < @ , radial inclination > @ , ulnar positive variance < @ mm and an articular step off < @ mm ) .", "sentence_id": 5}
+{"abstract_id": "24443982", "label": "methods", "text": "three weeks of plaster cast immobilization versus five weeks of plaster cast immobilization.Main study parameters : primary outcome parameters : Patient related wrist evaluation ( PRWE ) Quick Disability of Arm , Shoulder and Hand ( QUICKDASH ) score after a one year follow-up , and secondary parameters : range of motion , pain level ( VAS ) and complications .", "sentence_id": 6}
+{"abstract_id": "24443982", "label": "conclusions", "text": "The expectation of this study is that shorter duration of plaster cast immobilisation is beneficial for the patient with a distal radius fracture .", "sentence_id": 7}
+{"abstract_id": "24443982", "label": "conclusions", "text": "This risk of specific complications is low and generally similar in both treatment options .", "sentence_id": 8}
+{"abstract_id": "24443982", "label": "conclusions", "text": "Moreover , the burden of the study is not much higher compared to standard treatment .", "sentence_id": 9}
+{"abstract_id": "24443982", "label": "conclusions", "text": "Follow-up is standardized according to current trauma guidelines .", "sentence_id": 10}
+{"abstract_id": "24443982", "label": "conclusions", "text": "Literature indicates that both treatment options from the study are accepted for displaced distal radius fractures .", "sentence_id": 11}
+{"abstract_id": "24443982", "label": "conclusions", "text": "No clear advantage for one treatment options is found at present in the literature , although there is no level I evidence present .", "sentence_id": 12}
+{"abstract_id": "24443982", "label": "conclusions", "text": "This trial will provide level-@ evidence for the comparison of consolidation and functional outcome between two treatment options for non-displaced distal radial fractures .", "sentence_id": 13}
+{"abstract_id": "24443982", "label": "conclusions", "text": "The gathered data may support the development of a clinical guideline for conservative treatment of distal radial fractures .", "sentence_id": 14}
+{"abstract_id": "24265159", "label": "background", "text": "The event-free survival of childhood acute lymphoblastic leukemia ( ALL ) has been reported to be superior when oral methotrexate ( MTX ) and @-mercaptopurine ( @MP ) maintenance therapy ( MT ) is administered in the evening compared to the morning .", "sentence_id": 0}
+{"abstract_id": "24265159", "label": "methods", "text": "In the ALL@ MT study we prospectively registered the intake of MTX/@MP .", "sentence_id": 1}
+{"abstract_id": "24265159", "label": "methods", "text": "The registration was done when blood samples for erythrocyte MTX/@MP metabolite measurements were collected , and referred to the time of intake in the period since last registration .", "sentence_id": 2}
+{"abstract_id": "24265159", "label": "methods", "text": "Nine thousand one hundred ninety-five registrations in total .", "sentence_id": 3}
+{"abstract_id": "24265159", "label": "methods", "text": "The administration of MTX/@MP was scored as morning , midday , or evening .", "sentence_id": 4}
+{"abstract_id": "24265159", "label": "results", "text": "Of @ patients , @ took their medication consistently in the evening , @ in the evening @-@ @ % of the time , and @ in the evening < @ % of the time , six did not have any registrations .", "sentence_id": 5}
+{"abstract_id": "24265159", "label": "results", "text": "The circadian schedule did not differ significantly by age , sex , MTX/@MP doses , and average absolute neutrophil counts .", "sentence_id": 6}
+{"abstract_id": "24265159", "label": "results", "text": "The circadian schedule groups did differ on risk groups ( P = @ ) with fewer HR patients in the @-@ @ % group , and there was a negative correlation between percentage of time on evening schedule and average WBC ( Spearman 's rho -@ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24265159", "label": "results", "text": "Average WBC was not associated with relapse on ALL@ .", "sentence_id": 8}
+{"abstract_id": "24265159", "label": "results", "text": "In a Cox multivariate model the circadian schedule of MTX/@MP was not of prognostic significance for the risk of relapse , and the @-year cumulative relapse risk was below @ % in all groups .", "sentence_id": 9}
+{"abstract_id": "24265159", "label": "conclusions", "text": "An evening schedule may still be recommended based on the previous publications , but in this study morning administration of MTX and @MP does not seem to impact EFS .", "sentence_id": 10}
+{"abstract_id": "25710762", "label": "objective", "text": "To quantify plasma concentrations and determine adverse ocular , renal , or hepatic effects associated with repeated topical ophthalmic application of @ % diclofenac to healthy cats .", "sentence_id": 0}
+{"abstract_id": "25710762", "label": "methods", "text": "@ healthy sexually intact male cats .", "sentence_id": 1}
+{"abstract_id": "25710762", "label": "methods", "text": "A randomized , placebo-controlled crossover study was conducted .", "sentence_id": 2}
+{"abstract_id": "25710762", "label": "methods", "text": "A topical formulation of @ % diclofenac was administered @ times/d for @ days to @ cats , and artificial tear ( control ) solution was administered to the other @ cats .", "sentence_id": 3}
+{"abstract_id": "25710762", "label": "methods", "text": "After a @-day washout period , cats received the other treatment .", "sentence_id": 4}
+{"abstract_id": "25710762", "label": "methods", "text": "Ophthalmic examinations were performed daily .", "sentence_id": 5}
+{"abstract_id": "25710762", "label": "methods", "text": "Plasma samples were obtained on days @ and @ for pharmacokinetic analysis .", "sentence_id": 6}
+{"abstract_id": "25710762", "label": "methods", "text": "A CBC , serum biochemical analysis , urinalysis , determination of urine protein-to-creatinine ratio , and determination of glomerular filtration rate were performed before the start of the study and after each @-day treatment period .", "sentence_id": 7}
+{"abstract_id": "25710762", "label": "results", "text": "Mild conjunctival hyperemia was the only adverse ocular effect detected .", "sentence_id": 8}
+{"abstract_id": "25710762", "label": "results", "text": "Maximal drug concentration and area under the curve were significantly higher on day @ than on day @ .", "sentence_id": 9}
+{"abstract_id": "25710762", "label": "results", "text": "Diclofenac-treated cats had a significantly lower glomerular filtration rate than did control-treated cats after the second but not after the first treatment period , presumably associated with iatrogenic hypovolemia .", "sentence_id": 10}
+{"abstract_id": "25710762", "label": "conclusions", "text": "Topical ophthalmic administration of @ % diclofenac was well tolerated in healthy cats , with only mild signs of ocular irritation .", "sentence_id": 11}
+{"abstract_id": "25710762", "label": "conclusions", "text": "Detectable systemic concentrations of diclofenac were achieved with accumulation over @ days .", "sentence_id": 12}
+{"abstract_id": "25710762", "label": "conclusions", "text": "Systemic absorption of diclofenac may be associated with reduced glomerular filtration rate , particularly in volume-contracted animals .", "sentence_id": 13}
+{"abstract_id": "25710762", "label": "conclusions", "text": "Topical ophthalmic @ % diclofenac should be used with caution in volume-contracted or systemically ill cats .", "sentence_id": 14}
+{"abstract_id": "25636048", "label": "background", "text": "Mild primary hyperparathyroidism ( PHPT ) is a common disease especially in middle-aged and elderly women .", "sentence_id": 0}
+{"abstract_id": "25636048", "label": "background", "text": "The diagnosis is frequently made incidentally and treatment strategies are widely discussed .", "sentence_id": 1}
+{"abstract_id": "25636048", "label": "objective", "text": "To study the effect of parathyroidectomy ( PTX ) compared with observation ( OBS ) on biochemistry , safety , bone mineral density ( BMD ) , and new fractures .", "sentence_id": 2}
+{"abstract_id": "25636048", "label": "methods", "text": "Prospective , randomized controlled study ( SIPH study ) , with a @-year follow-up .", "sentence_id": 3}
+{"abstract_id": "25636048", "label": "methods", "text": "The study was conducted at multicenter , tertiary referral centers .", "sentence_id": 4}
+{"abstract_id": "25636048", "label": "methods", "text": "Of @ randomized patients with mild PHPT , biochemical data were available for @ patients after @ years , with a mean age at inclusion of @ years ( OBS group , @ males ) and @ years ( PTX group , @ males ) .", "sentence_id": 5}
+{"abstract_id": "25636048", "label": "methods", "text": "Parathyroidectomy vs observation .", "sentence_id": 6}
+{"abstract_id": "25636048", "label": "methods", "text": "Biochemistry , BMD , and new radiographic vertebral fractures .", "sentence_id": 7}
+{"abstract_id": "25636048", "label": "results", "text": "Serum-calcium and PTH-levels normalized after surgery and did not deteriorate by observation .", "sentence_id": 8}
+{"abstract_id": "25636048", "label": "results", "text": "BMD Z-scores were normal at inclusion in the lumbar spine ( LS ) and femoral neck ( FN ) .", "sentence_id": 9}
+{"abstract_id": "25636048", "label": "results", "text": "For LS , BMD Z-scores were stable for @ years with observation , but decreased in FN ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25636048", "label": "results", "text": "After surgery , BMD Z-scores increased significantly in both compartments ( P < @ for both ) , with a highly significant treatment effect of surgery compared to observation ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25636048", "label": "results", "text": "During follow-up , five new clinically unrecognized vertebral fractures were found in @ females , all in the OBS group ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25636048", "label": "conclusions", "text": "Even though new vertebral fractures occurred only in the observation group , the frequency was not significantly different from the surgery group .", "sentence_id": 13}
+{"abstract_id": "25636048", "label": "conclusions", "text": "Longer follow-up is needed before firm conclusions can be drawn about the long-term safety of observation , as opposed to surgery .", "sentence_id": 14}
+{"abstract_id": "24965060", "label": "background", "text": "The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix ( ADM ) materials produced by different processing techniques , freeze-dried ( FDADM ) and solvent-dehydrated ( SDADM ) ADM , in their ability to correct Miller Class I and II recession defects .", "sentence_id": 0}
+{"abstract_id": "24965060", "label": "methods", "text": "Eighty individuals from four study centers , each with a single maxillary anterior Miller Class I or II recession defect were enrolled .", "sentence_id": 1}
+{"abstract_id": "24965060", "label": "methods", "text": "Participants were randomly assigned and treated with coronally advanced flap ( CAF ) + FDADM ( n = @ ) or CAF + SDADM ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24965060", "label": "methods", "text": "Gingival thickness , recession depth , recession width , probing depth ( PD ) , clinical attachment level , gingival index , plaque index , patient discomfort , and wound healing index were recorded before surgery ( day @ ) , immediately after surgery ( day @ ) , and @ , @ , @ , @ , and @ weeks postoperatively .", "sentence_id": 3}
+{"abstract_id": "24965060", "label": "methods", "text": "The Student t test , paired t test , and Kruskal-Wallis one-way ANOVA were used to analyze the data .", "sentence_id": 4}
+{"abstract_id": "24965060", "label": "results", "text": "When evaluating the clinical parameters after @ year , both groups showed significant ( P < @ ) improvement for most of the parameters evaluated when compared to baseline ( day @ ) .", "sentence_id": 5}
+{"abstract_id": "24965060", "label": "results", "text": "For example , percentage of root coverage was @ % @ % for CAF + FDADM and @ % @ % for CAF + SDADM .", "sentence_id": 6}
+{"abstract_id": "24965060", "label": "results", "text": "Conversely , no significant differences were observed between the two materials for any clinical parameter tested or for patient satisfaction except PD on the mesial side of the defects ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24965060", "label": "conclusions", "text": "Both FDADM and SDADM can be used successfully to correct Miller Class I or II recession defects .", "sentence_id": 8}
+{"abstract_id": "24965060", "label": "conclusions", "text": "There were no statistically significant differences between groups for any of the clinical parameters tested .", "sentence_id": 9}
+{"abstract_id": "24889213", "label": "background", "text": "Total Hip Arthroplasty ( THA ) is being used more commonly in younger higher demand patients .", "sentence_id": 0}
+{"abstract_id": "24889213", "label": "background", "text": "The purpose of this randomized pilot study was to explore a ) feasibility of comprehensive postoperative rehabilitation compared to usual care following primary THA in subjects < @ years , b ) appropriate outcome measures including performance-based measures and c ) timing of assessments .", "sentence_id": 1}
+{"abstract_id": "24889213", "label": "methods", "text": "@ subjects who underwent primary THA were randomized to receive a three-month out-patient rehabilitation program ( Intervention ) or usual postoperative care ( Control ) .", "sentence_id": 2}
+{"abstract_id": "24889213", "label": "methods", "text": "Subjects were assessed preoperatively , six-weeks postoperatively ( Pre-intervention ) and four and @ months postoperatively ( Post-intervention ) .", "sentence_id": 3}
+{"abstract_id": "24889213", "label": "methods", "text": "Self-report measures were the Western Ontario McMaster Osteoarthritis Index ( WOMAC ) and Rand @-Item Health Survey ( RAND-@ ) .", "sentence_id": 4}
+{"abstract_id": "24889213", "label": "methods", "text": "Performance-based measures included lower extremity strength , walking speed and endurance , and gait laboratory assessment .", "sentence_id": 5}
+{"abstract_id": "24889213", "label": "results", "text": "Ten Control and @ Intervention subjects with an average age of @ ( SD@ @ ) years were randomized .", "sentence_id": 6}
+{"abstract_id": "24889213", "label": "results", "text": "All Intervention subjects completed the program without adverse effects .", "sentence_id": 7}
+{"abstract_id": "24889213", "label": "results", "text": "Although no statistically significantly results were reported , four months postoperatively , Intervention subjects had clinically important differences ( CID ) in strength compared with Control subjects .", "sentence_id": 8}
+{"abstract_id": "24889213", "label": "results", "text": "Walking endurance , WOMAC and RAND scores improved significantly with no CID noted between groups .", "sentence_id": 9}
+{"abstract_id": "24889213", "label": "results", "text": "Ten ( @ % ) subjects reported a ceiling effect on the WOMAC ( @ ( @ % ) subjects on Pain ; @ ( @ % ) subject on Function ) .", "sentence_id": 10}
+{"abstract_id": "24889213", "label": "results", "text": "No group CID were noted in gait measures .", "sentence_id": 11}
+{"abstract_id": "24889213", "label": "conclusions", "text": "Our recommendations would be that performance-based strength measures should be considered for the primary outcome in this younger cohort .", "sentence_id": 12}
+{"abstract_id": "24889213", "label": "conclusions", "text": "Because of the ceiling effects with WOMAC Pain , a different pain measure is indicated .", "sentence_id": 13}
+{"abstract_id": "24889213", "label": "conclusions", "text": "Other more challenging functional performance-based tests should be considered such as a more prolonged endurance test .", "sentence_id": 14}
+{"abstract_id": "24889213", "label": "conclusions", "text": "There is merit in one-year follow-up as strength improved after four months in both groups .", "sentence_id": 15}
+{"abstract_id": "24429202", "label": "background", "text": "Long-term complications of cystic fibrosis include osteoporosis and fragility fractures , but few data are available about effective treatment strategies , especially in young patients .", "sentence_id": 0}
+{"abstract_id": "24429202", "label": "background", "text": "We investigated treatment of low bone mineral density in children , adolescents , and young adults with cystic fibrosis .", "sentence_id": 1}
+{"abstract_id": "24429202", "label": "methods", "text": "We did a multicentre trial in two phases .", "sentence_id": 2}
+{"abstract_id": "24429202", "label": "methods", "text": "We enrolled patients aged @-@ years with cystic fibrosis and low bone mineral density , from ten cystic fibrosis regional centres in Italy .", "sentence_id": 3}
+{"abstract_id": "24429202", "label": "methods", "text": "The first phase was an open-label , @-month observational study of the effect of adequate calcium intake plus calcifediol .", "sentence_id": 4}
+{"abstract_id": "24429202", "label": "methods", "text": "The second phase was a @-month , double-blind , randomised , placebo-controlled , parallel group study of the efficacy and safety of oral alendronate in patients whose bone mineral apparent density had not increased by @ % or more by the end of the observational phase .", "sentence_id": 5}
+{"abstract_id": "24429202", "label": "methods", "text": "Patients were randomly assigned to either alendronate or placebo .", "sentence_id": 6}
+{"abstract_id": "24429202", "label": "methods", "text": "Both patients and investigators were masked to treatment assignment .", "sentence_id": 7}
+{"abstract_id": "24429202", "label": "methods", "text": "We used dual x-ray absorptiometry at baseline and every @ months thereafter , corrected for body size , to assess lumbar spine bone mineral apparent density .", "sentence_id": 8}
+{"abstract_id": "24429202", "label": "methods", "text": "We assessed bone turnover markers and other laboratory parameters every @-@ months .", "sentence_id": 9}
+{"abstract_id": "24429202", "label": "methods", "text": "The primary endpoint was mean increase of lumbar spine bone mineral apparent density , assessed in the intention-to-treat population .", "sentence_id": 10}
+{"abstract_id": "24429202", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 11}
+{"abstract_id": "24429202", "label": "results", "text": "We screened @ patients and enrolled @ ( mean age @ years , SD @ , range @-@ ) .", "sentence_id": 12}
+{"abstract_id": "24429202", "label": "results", "text": "In the observational phase , treatment with calcium and calcifediol increased bone mineral apparent density by @ % or more in @ patients ( @ % ) .", "sentence_id": 13}
+{"abstract_id": "24429202", "label": "results", "text": "@ patients entered the randomised phase .", "sentence_id": 14}
+{"abstract_id": "24429202", "label": "results", "text": "Bone mineral apparent density increased by @ % in the alendronate group ( n = @ ) versus @ % in the placebo group ( n = @ ; p = @ ) .", "sentence_id": 15}
+{"abstract_id": "24429202", "label": "results", "text": "@ of @ young people ( @ % ) receiving alendronate attained a normal-for-age bone mineral apparent density Z score .", "sentence_id": 16}
+{"abstract_id": "24429202", "label": "results", "text": "In the observational phase , five patients had moderate episodes of hypercalciuria , which resolved after short interruption of calcifediol treatment .", "sentence_id": 17}
+{"abstract_id": "24429202", "label": "results", "text": "During the randomised phase , one patient taking alendronate had mild fever versus none in the placebo group ; treatment groups did not differ significantly for other adverse events .", "sentence_id": 18}
+{"abstract_id": "24429202", "label": "conclusions", "text": "Correct calcium intake plus calcifediol can improve bone mineral density in some young patients with cystic fibrosis .", "sentence_id": 19}
+{"abstract_id": "24429202", "label": "conclusions", "text": "In those who do not respond to calcium and calcifediol alone , alendronate can safely and effectively increase bone mineral density .", "sentence_id": 20}
+{"abstract_id": "25005045", "label": "background", "text": "The optimal crystalloid solution to use perioperatively in patients undergoing open radical cystectomy remains unclear .", "sentence_id": 0}
+{"abstract_id": "25005045", "label": "background", "text": "Many of the fluids used for intravenous hydration contain supraphysiologic concentrations of chloride , which can induce hyperchloremia and metabolic acidosis , resulting in renal vasoconstriction and decreased renal function .", "sentence_id": 1}
+{"abstract_id": "25005045", "label": "background", "text": "In addition , patients receiving less fluid and less sodium show faster recovery of gastrointestinal ( GI ) function after colonic surgery .", "sentence_id": 2}
+{"abstract_id": "25005045", "label": "methods", "text": "This is an investigator-initiated , single-center , randomized , controlled , parallel group trial with assessor-blinded outcome assessment , in the Department of Urology , University Hospital Bern , Switzerland .", "sentence_id": 3}
+{"abstract_id": "25005045", "label": "methods", "text": "The study will involve @ patients with bladder cancer scheduled for radical cystectomy and urinary diversion .", "sentence_id": 4}
+{"abstract_id": "25005045", "label": "methods", "text": "The primary outcome is the duration between the end of surgery and the return of the GI function ( first defecation ) .", "sentence_id": 5}
+{"abstract_id": "25005045", "label": "methods", "text": "Secondary outcomes are fluid balance ( body weight difference postoperatively versus preoperatively ) and the incidence of kidney function disorders according to the Risk-Injury-Failure-Loss-End Stage Renal Disease ( RIFLE classification ) .", "sentence_id": 6}
+{"abstract_id": "25005045", "label": "methods", "text": "An equal number of patients are allocated to receive Ringerfundin solution or a glucose/potassium-based balanced crystalloid solution as baseline infusion during the entire time that intravenous administration of fluid is necessary during the perioperative period .", "sentence_id": 7}
+{"abstract_id": "25005045", "label": "methods", "text": "The randomized crystalloid solution is infused at a rate of @ ml/kg/h until the bladder has been removed , followed by @ ml/kg/h until the end of surgery .", "sentence_id": 8}
+{"abstract_id": "25005045", "label": "methods", "text": "Postoperative hydration is identical in both groups and consists of @,@ ml of the randomized crystalloid solution per @ hours .", "sentence_id": 9}
+{"abstract_id": "25005045", "label": "methods", "text": "Postoperative patient care is identical in both groups ; patients are allowed to drink clear fluids immediately after surgery , and liquid diet is started on postoperative day @ , as well as active mobilization and the use of chewing gum .", "sentence_id": 10}
+{"abstract_id": "25005045", "label": "methods", "text": "Body weight is measured daily in the morning .", "sentence_id": 11}
+{"abstract_id": "25005045", "label": "methods", "text": "Time of first flatus and first defecation are recorded .", "sentence_id": 12}
+{"abstract_id": "25005045", "label": "conclusions", "text": "This trial assesses the benefits and harms of two different balanced crystalloid solutions for perioperative fluid management in patients undergoing open radical cystectomy with urinary diversion , with regard to return of GI function and effects on postoperative renal function .", "sentence_id": 13}
+{"abstract_id": "25200821", "label": "objective", "text": "Tubal factor accounts for @-@ % of cases of female infertility .", "sentence_id": 0}
+{"abstract_id": "25200821", "label": "objective", "text": "Laparoscopy `` Gold Standard '' for tubal evaluation .", "sentence_id": 1}
+{"abstract_id": "25200821", "label": "objective", "text": "However , it is known that during the initial infection of the fallopian tube mucosal damage occurs , a condition which plays a decisive role in reproduction .", "sentence_id": 2}
+{"abstract_id": "25200821", "label": "methods", "text": "In this prospective randomized study , @ infertile women with evidence of fallopian tube disease were included .", "sentence_id": 3}
+{"abstract_id": "25200821", "label": "methods", "text": "In this , for @ patients ( group @ ) after laparoscopic salpingolysis , salpingostomy we performed an additional step operation transcervical falloposcopy tubal dilatation ( TFTD ) .", "sentence_id": 4}
+{"abstract_id": "25200821", "label": "methods", "text": "@ patients ( group @ ) produced only laparoscopic salpingolysis , salpingostomy .", "sentence_id": 5}
+{"abstract_id": "25200821", "label": "results", "text": "As a result , TFTD patency of the fallopian tubes for coaxial catheter was restored in @ ( @ % ) of @ tubes with bilateral total occlusion , in @ ( @ % ) of @ with partial occlusion of the bilateral , in @ ( @ % ) of @ total unilateral occlusion and @ ( @ % ) of @ with partial unilateral occlusion .", "sentence_id": 6}
+{"abstract_id": "25200821", "label": "results", "text": "Total number of pregnancies for one year in the first group of patients was @ ( @ % ) , in the second @ ( @ % ) , of which in the first group @ - intrauterine pregnancies ( @ % ) and in the second - @ ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25200821", "label": "conclusions", "text": "Falloposcopy surgeon provides good opportunities for the diagnosis and treatment of intralumen lesions .", "sentence_id": 8}
+{"abstract_id": "25200821", "label": "conclusions", "text": "Significant increase in the frequency of uterine pregnancy in the case of an additional step - TFTD during salpingolysis , salpingostomy in patients with tubal factor infertility .", "sentence_id": 9}
+{"abstract_id": "24582119", "label": "objective", "text": "To determine clinical and demographic characteristics associated with antimuscarinic treatment response using a regression model .", "sentence_id": 0}
+{"abstract_id": "24582119", "label": "methods", "text": "Adults with overactive bladder ( OAB ) symptoms for > @ months and @ urgency urinary incontinence ( UUI ) episode and @ micturitions per @ hours at baseline were randomized to fesoterodine ( @ mg ) , tolterodine extended-release ( @ mg ) , or placebo in two @-week , double-blind , head-to-head studies .", "sentence_id": 1}
+{"abstract_id": "24582119", "label": "methods", "text": "Fesoterodine-treated patients received @ mg/d during the first week and @ mg/d thereafter .", "sentence_id": 2}
+{"abstract_id": "24582119", "label": "methods", "text": "Patients completed @-day bladder diaries and the Overactive Bladder Questionnaire at baseline and week @ .", "sentence_id": 3}
+{"abstract_id": "24582119", "label": "methods", "text": "Pooled data for changes from baseline to week @ in winsorized UUI episodes , micturitions , and urgency episodes per @ hours and Overactive Bladder Questionnaire Symptom Bother and health-related quality of life scores were analyzed posthoc using a regression model that selects outcome predictors from baseline values and patient characteristics while retaining baseline values and treatment , with stepwise inclusion of significant covariates and assessment of treatment interactions .", "sentence_id": 4}
+{"abstract_id": "24582119", "label": "methods", "text": "Logistic regression was used for analysis of diary-dry rates .", "sentence_id": 5}
+{"abstract_id": "24582119", "label": "results", "text": "Younger age , lack of previous antimuscarinic treatment , shorter duration of OAB diagnosis , and female gender were common predictors of larger changes in outcomes from baseline to week @ .", "sentence_id": 6}
+{"abstract_id": "24582119", "label": "results", "text": "Baseline measures often interacted with treatment , such that poorer baseline outcomes were predictive of larger treatment differences .", "sentence_id": 7}
+{"abstract_id": "24582119", "label": "results", "text": "Longer duration since OAB diagnosis predicted greater treatment differences for UUI episodes and in diary-dry rate , and increased age predicted greater treatment differences for micturitions .", "sentence_id": 8}
+{"abstract_id": "24582119", "label": "conclusions", "text": "Symptom severity and duration , age , gender , and previous antimuscarinic pharmacotherapy impact the response to antimuscarinic treatment .", "sentence_id": 9}
+{"abstract_id": "24441734", "label": "objective", "text": "To compare long-term functional and radiological outcome following microfracture technique ( MF ) versus osteochondral autologous transplantation ( OAT ) mosaicplasty for treating focal chondral lesions of the knee .", "sentence_id": 0}
+{"abstract_id": "24441734", "label": "methods", "text": "Twenty-five patients ( mean age @ years , SD @ ) with a full-thickness ( International Cartilage Repair Society grade @ or @ ) chondral lesion of the articulating surface of the femur were randomized to either MF ( n = @ ) or OAT mosaicplasty ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24441734", "label": "methods", "text": "At a median follow-up of @ years ( range @-@ @ ) , the patients were evaluated using Lysholm score ( n = @ ) , Knee Injury and Osteoarthritis Outcome Score ( KOOS , n = @ ) , isokinetic quadriceps measurement and hamstring strength measurement ( n = @ ) and standing radiographs ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24441734", "label": "results", "text": "There were no significant differences in Lysholm score , KOOS , isokinetic muscle strength or radiographic osteoarthritis between MF-treated patients and OAT mosaicplasty-treated patients at follow-up .", "sentence_id": 3}
+{"abstract_id": "24441734", "label": "results", "text": "Mean Lysholm score at follow-up was @ -LSB- @ % confidence interval ( CI ) , @-@ @ -RSB- for the MF group and @ ( @ % CI , @-@ @ ) for the OAT mosaicplasty group .", "sentence_id": 4}
+{"abstract_id": "24441734", "label": "conclusions", "text": "At long-term follow-up , there were no significant differences between patients treated with MF and patients treated with OAT mosaicplasty in patient-reported outcomes , muscle strength or radiological outcome .", "sentence_id": 5}
+{"abstract_id": "24441734", "label": "methods", "text": "Therapeutic study , Level II .", "sentence_id": 6}
+{"abstract_id": "25463664", "label": "background", "text": "Studies suggest that smokers present more or greater numbers of potential periodontal pathogens than non-smokers .", "sentence_id": 0}
+{"abstract_id": "25463664", "label": "background", "text": "The aim of this study was to investigate the microbiologic effects of adjunctive aPDT on nonsurgical periodontal treatment in smokers with chronic periodontitis ( CP ) .", "sentence_id": 1}
+{"abstract_id": "25463664", "label": "methods", "text": "Twenty smokers with CP had two contralateral teeth randomly assigned in a split-mouth design to receive SRP ( CG ) or SRP + a single episode of aPDT ( TG ) , with a diode laser and a phenothiazine photosensitizer .", "sentence_id": 2}
+{"abstract_id": "25463664", "label": "methods", "text": "Levels of @ subgingival species were measured using checkerboard DNA-DNA hybridization at baseline and @ , @ and @ weeks after periodontal treatment .", "sentence_id": 3}
+{"abstract_id": "25463664", "label": "results", "text": "All @ bacterial species evaluated were detected in different levels at baseline , with no statistic significant differences between groups .", "sentence_id": 4}
+{"abstract_id": "25463664", "label": "results", "text": "After periodontal treatment , the levels of some bacterial species decreased , while some other species presented an increase .", "sentence_id": 5}
+{"abstract_id": "25463664", "label": "results", "text": "Despite this variation , the statistical analysis was not able to identify significant differences neither at intragroup nor at intergroup comparisons .", "sentence_id": 6}
+{"abstract_id": "25463664", "label": "conclusions", "text": "Periodontal treatment with SRP or SRP + aPDT was not able to reduce levels of @ subgingival species in smokers with CP .", "sentence_id": 7}
+{"abstract_id": "25463664", "label": "conclusions", "text": "These outcomes indicate that smoking impairs periodontal healing after nonsurgical treatment even associated with aPDT .", "sentence_id": 8}
+{"abstract_id": "24429164", "label": "objective", "text": "To evaluate whether patients with rheumatoid arthritis who did not respond sufficiently to tocilizumab ( TCZ ) plus disease-modifying antirheumatic drug ( DMARD ) treatment by Week @ responded at later timepoints when continuing to take their original dose of TCZ .", "sentence_id": 0}
+{"abstract_id": "24429164", "label": "methods", "text": "In this posthoc analysis of data from phase III randomized controlled trials of inadequate responders ( IR ) to DMARD or tumor necrosis factor - inhibitors ( anti-TNF ) , percentages of patients meeting early response criteria were calculated by randomized treatment arm ( TCZ @ mg/kg , @ mg/kg , or placebo in combination with DMARD ) .", "sentence_id": 1}
+{"abstract_id": "24429164", "label": "methods", "text": "Percentages of patients achieving certain disease activity thresholds at later timepoints were calculated for patients who had/had not achieved response by Week @ .", "sentence_id": 2}
+{"abstract_id": "24429164", "label": "results", "text": "In DMARD-IR early nonresponders , @ % , @ % , and @ % of TCZ @ mg/kg-randomized , TCZ @ mg/kg-randomized , and placebo-randomized patients , respectively , achieved @-joint Disease Activity Score ( DAS@ ) @ by Week @ .", "sentence_id": 3}
+{"abstract_id": "24429164", "label": "results", "text": "Among anti-TNF-IR patients without early response , @ % , @ % , and @ % of TCZ @ mg/kg-randomized , TCZ @ mg/kg-randomized , and placebo-randomized patients , respectively , achieved DAS@ @ at Week @ .", "sentence_id": 4}
+{"abstract_id": "24429164", "label": "conclusions", "text": "A substantial number of DMARD-IR patients taking TCZ @ or @ mg/kg and anti-TNF-IR patients taking TCZ @ mg/kg who failed to respond by @ weeks benefited from continued TCZ treatment in combination with DMARD .", "sentence_id": 5}
+{"abstract_id": "24429164", "label": "conclusions", "text": "In contrast , the anti-TNF-IR patients without early responses who continued to take TCZ @ mg/kg were unlikely to experience a cumulative benefit .", "sentence_id": 6}
+{"abstract_id": "24429164", "label": "conclusions", "text": "ClinicalTrials.gov registration numbers : NCT@ , NCT@ , NCT@ , NCT@ .", "sentence_id": 7}
+{"abstract_id": "25277144", "label": "objective", "text": "The objective of this study was to assess the safety , tolerability , pharmacokinetics , and pharmacodynamics of selexipag , an orally available selective prostacyclin receptor agonist , in development for pulmonary arterial hypertension in healthy subjects .", "sentence_id": 0}
+{"abstract_id": "25277144", "label": "methods", "text": "This was a double-blind , placebo-controlled , randomised , multiple-ascending-dose , up-titration study .", "sentence_id": 1}
+{"abstract_id": "25277144", "label": "methods", "text": "Male subjects received increasing oral doses of selexipag ( @-@ ,@ g ; n = @ ) or placebo ( n = @ ) twice daily for @ days each , using incremental steps of @ g between each dose level .", "sentence_id": 2}
+{"abstract_id": "25277144", "label": "methods", "text": "Standard safety and tolerability data were collected .", "sentence_id": 3}
+{"abstract_id": "25277144", "label": "methods", "text": "Blood samples were taken to assess the pharmacokinetics of selexipag and its active metabolite ACT-@ and possible effects on platelet aggregation .", "sentence_id": 4}
+{"abstract_id": "25277144", "label": "results", "text": "Dose levels of selexipag up to @,@ g were well tolerated and this dose was identified as the maximum tolerated dose .", "sentence_id": 5}
+{"abstract_id": "25277144", "label": "results", "text": "Plasma exposure to ACT-@ was approximately @ times higher than that to selexipag .", "sentence_id": 6}
+{"abstract_id": "25277144", "label": "results", "text": "Steady-state conditions for both compounds were reached on day @ of each dose level , and no accumulation of selexipag or ACT-@ was observed .", "sentence_id": 7}
+{"abstract_id": "25277144", "label": "results", "text": "Based on the area under the curve and the maximum plasma concentration , the pharmacokinetics of selexipag and ACT-@ were dose proportional .", "sentence_id": 8}
+{"abstract_id": "25277144", "label": "results", "text": "At the highest dose level , the geometric mean terminal half-life of selexipag and ACT-@ was @ and @ h , respectively .", "sentence_id": 9}
+{"abstract_id": "25277144", "label": "results", "text": "The observed effects on platelet aggregation were variable without obvious drug - or dose-dependent pattern .", "sentence_id": 10}
+{"abstract_id": "25277144", "label": "conclusions", "text": "Oral administration of increasing doses of selexipag was well tolerated .", "sentence_id": 11}
+{"abstract_id": "25277144", "label": "conclusions", "text": "The present results support the conduct of future clinical trials .", "sentence_id": 12}
+{"abstract_id": "25512670", "label": "background", "text": "The objective of this study was to compare the costs and outcomes of two sexually transmitted infection ( STI ) screening interventions targeted at men in football club settings in England , including screening promoted by team captains .", "sentence_id": 0}
+{"abstract_id": "25512670", "label": "methods", "text": "A comparison of costs and outcomes was undertaken alongside a pilot cluster randomised control trial involving three trial arms : ( @ ) captain-led and poster STI screening promotion ; ( @ ) sexual health advisor-led and poster STI screening promotion and ( @ ) poster-only STI screening promotion ( control/comparator ) .", "sentence_id": 1}
+{"abstract_id": "25512670", "label": "methods", "text": "For all study arms , resource use and cost data were collected prospectively .", "sentence_id": 2}
+{"abstract_id": "25512670", "label": "results", "text": "There was considerable variation in uptake rates between clubs , but results were broadly comparable across study arms with @ % of men accepting the screening offer in the captain-led arm , @ % in the sexual health advisor-led arm and @ % in the poster-only control arm .", "sentence_id": 3}
+{"abstract_id": "25512670", "label": "results", "text": "The overall costs associated with the intervention arms were similar .", "sentence_id": 4}
+{"abstract_id": "25512670", "label": "results", "text": "The average cost per player tested was comparable , with the average cost per player tested for the captain-led promotion estimated to be @ compared with @ for the sexual health advisor-led promotion and @ for the poster-only ( control ) arm .", "sentence_id": 5}
+{"abstract_id": "25512670", "label": "conclusions", "text": "Costs and outcomes were similar across intervention arms .", "sentence_id": 6}
+{"abstract_id": "25512670", "label": "conclusions", "text": "The target sample size was not achieved , and we found a greater than anticipated variability between clubs in the acceptability of screening , which limited our ability to estimate acceptability for intervention arms .", "sentence_id": 7}
+{"abstract_id": "25512670", "label": "conclusions", "text": "Further evidence is needed about the public health benefits associated with screening interventions in non-clinical settings so that their cost-effectiveness can be fully evaluated .", "sentence_id": 8}
+{"abstract_id": "24660603", "label": "objective", "text": "To explore the regulatory effects of established Chinese herbal formulas on inflammatory mediators released during asthma attacks , and to elucidate the molecular mechanism of Traditional Chinese Medicine in the treatment of asthma .", "sentence_id": 0}
+{"abstract_id": "24660603", "label": "methods", "text": "Seventy-five asthmatic children were randomly divided into a Chinese medication group ( @ cases ) and a Western medication control group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24660603", "label": "methods", "text": "Patients in the Chinese medication group were treated with a series of established Chinese herbal formulas , whereas the Western medication control group received a leukotriene receptor antagonist and a bronchial relaxant .", "sentence_id": 2}
+{"abstract_id": "24660603", "label": "methods", "text": "Real-time PCR was used to determine the mRNA expression levels of interleukin ( IL ) -@ , cysteinyl leukotriene receptor @ ( CysLTR@ ) , and interferon ( IFN ) - gamma in peripheral blood mononuclear cells before and after treatment .", "sentence_id": 3}
+{"abstract_id": "24660603", "label": "methods", "text": "Enzyme-linked immunosorbent assay was used to measure the peripheral blood levels of IL-@ , leukotriene ( LTE ) -@ , and INF-gamma before and after treatment .", "sentence_id": 4}
+{"abstract_id": "24660603", "label": "results", "text": "After treatment , the mRNA expression levels of IL-@ and CysLTR@ were down-regulated ( P < @ ) and the mRNA expression levels of IFN-gamma were up-regulated ( P < @ ) in the Chinese medication and Western medication groups ; no significant difference was found between the two groups .", "sentence_id": 5}
+{"abstract_id": "24660603", "label": "results", "text": "In the Chinese medication group , IL-@ blood level was decreased and it was significantly different from that in the Western medication group ( P < @ ) ; there was also a significant increase in IFN-gamma blood levels after treatment with Chinese medication ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24660603", "label": "results", "text": "There were no significant differences in LTE-@ blood levels between the two groups before and after treatment ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24660603", "label": "conclusions", "text": "Chinese medication has a regulatory effect on leukotriene receptor gene expression and the imbalance of Th@/Th@ immune cells during asthma attacks in pediatric patients .", "sentence_id": 8}
+{"abstract_id": "24725787", "label": "objective", "text": "To determine inter-rater reliability in identifying a knee extension lag using the sitting active and prone passive lag test ( SAPLT ) .", "sentence_id": 0}
+{"abstract_id": "24725787", "label": "methods", "text": "@ patients with a diagnosis of knee pain were randomly assigned and independently examined by two physical therapists at a time , to determine the presence of an active or a passive extension lag at the knee .", "sentence_id": 1}
+{"abstract_id": "24725787", "label": "methods", "text": "An active lag was determined by the inability of the erectly seated subject to actively extend the involved knee in maximal dorsiflexion of the ankle to the same level as the normal knee held in maximal extension and ankle in maximal dorsiflexion , as seen by the levels of the toes .", "sentence_id": 2}
+{"abstract_id": "24725787", "label": "methods", "text": "A passive lag was determined by placing the subject prone with the knees just past the edge of the table and determining the high position of the heel in a fully resting extension position compared to the heel on the normal side .", "sentence_id": 3}
+{"abstract_id": "24725787", "label": "results", "text": "For the sitting active lag test , the inter-rater reliability was ` good ' ( Kappa @ , SE of kappa @ , @ % confidence interval ) .", "sentence_id": 4}
+{"abstract_id": "24725787", "label": "results", "text": "For the prone passive lag test , the inter-rater reliability was ` good ' ( Kappa @ , SE of kappa @ , @ % confidence interval ) .", "sentence_id": 5}
+{"abstract_id": "24725787", "label": "conclusions", "text": "The SAPLT may be incorporated as a simple yet effective test to determine the presence of a knee extension lag .", "sentence_id": 6}
+{"abstract_id": "24725787", "label": "conclusions", "text": "It identifies the type of restraint , active , passive or both , and is suggestive of the most appropriate management .", "sentence_id": 7}
+{"abstract_id": "25274048", "label": "background", "text": "In a large cluster-randomized trial on the impact of a prediction model , presenting the calculated risk of postoperative nausea and vomiting ( PONV ) on-screen ( assistive approach ) increased the administration of risk-dependent PONV prophylaxis by anaesthetists .", "sentence_id": 0}
+{"abstract_id": "25274048", "label": "background", "text": "This change in therapeutic decision-making did not improve the patient outcome ; that is , the incidence of PONV .", "sentence_id": 1}
+{"abstract_id": "25274048", "label": "background", "text": "The present study aimed to quantify the effects of adding a specific therapeutic recommendation to the predicted risk ( directive approach ) on PONV prophylaxis decision-making and the incidence of PONV .", "sentence_id": 2}
+{"abstract_id": "25274048", "label": "methods", "text": "A prospective before-after study was conducted in @ elective surgical inpatients .", "sentence_id": 3}
+{"abstract_id": "25274048", "label": "methods", "text": "The before-period included care-as-usual and the after-period included the directive risk-based ( intervention ) strategy .", "sentence_id": 4}
+{"abstract_id": "25274048", "label": "methods", "text": "Risk-dependent effects on the administered number of prophylactic antiemetics and incidence of PONV were analysed by mixed-effects regression analysis .", "sentence_id": 5}
+{"abstract_id": "25274048", "label": "results", "text": "During the intervention period anaesthetists administered @ -LSB- @ % confidence intervals ( CIs ) : @-@ @ -RSB- more antiemetics for patients identified as being at greater risk of PONV .", "sentence_id": 6}
+{"abstract_id": "25274048", "label": "results", "text": "This directive approach led to a reduction in PONV -LSB- odds ratio ( OR ) : @ , @ % CI : @-@ @ -RSB- , with an even greater reduction in PONV in high-risk patients ( OR : @ , @ % CI : @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "25274048", "label": "conclusions", "text": "Anaesthetists administered more prophylactic antiemetics when a directive approach was used for risk-tailored intervention compared with care-as-usual .", "sentence_id": 8}
+{"abstract_id": "25274048", "label": "conclusions", "text": "In contrast to the previously studied assistive approach , the increase in PONV prophylaxis now resulted in a lower PONV incidence , particularly in high-risk patients .", "sentence_id": 9}
+{"abstract_id": "25274048", "label": "conclusions", "text": "When one aims for a truly ` PONV-free hospital ' , a more liberal use of prophylactic antiemetics must be accepted and lower-risk thresholds should be set for the actionable recommendations .", "sentence_id": 10}
+{"abstract_id": "24601857", "label": "objective", "text": "Several field triage systems have been developed to rapidly sort patients following a mass casualty incident ( MCI ) .", "sentence_id": 0}
+{"abstract_id": "24601857", "label": "objective", "text": "JumpSTART ( Simple Triage and Rapid Transport ) is a pediatric-specific MCI triage system .", "sentence_id": 1}
+{"abstract_id": "24601857", "label": "objective", "text": "SALT ( Sort , Assess , Lifesaving interventions , Treat/Transport ) has been proposed as a new national standard for MCI triage for both adult and pediatric patients , but it has not been tested in a pediatric population .", "sentence_id": 2}
+{"abstract_id": "24601857", "label": "objective", "text": "This pilot study hypothesizes that SALT is at least as good as JumpSTART in triage accuracy , speed , and ease of use in a simulated pediatric MCI .", "sentence_id": 3}
+{"abstract_id": "24601857", "label": "methods", "text": "Paramedics were invited and randomly assigned to either SALT or JumpSTART study groups .", "sentence_id": 4}
+{"abstract_id": "24601857", "label": "methods", "text": "Following randomization , subjects viewed a @-minute PowerPoint lecture on either JumpSTART or SALT .", "sentence_id": 5}
+{"abstract_id": "24601857", "label": "methods", "text": "Subjects were provided with a triage algorithm card for reference and were asked to assign triage categories to @ pediatric patients in a simulated building collapse .", "sentence_id": 6}
+{"abstract_id": "24601857", "label": "methods", "text": "The scenario consisted of @ children in moulage and @ high-fidelity pediatric simulators .", "sentence_id": 7}
+{"abstract_id": "24601857", "label": "methods", "text": "Injuries and triage categories were based on a previously published MCI scenario .", "sentence_id": 8}
+{"abstract_id": "24601857", "label": "methods", "text": "One investigator followed each subject to record time and triage assignment .", "sentence_id": 9}
+{"abstract_id": "24601857", "label": "methods", "text": "All subjects completed a post-test survey and structured interview following the simulated disaster .", "sentence_id": 10}
+{"abstract_id": "24601857", "label": "results", "text": "Forty-three paramedics were enrolled .", "sentence_id": 11}
+{"abstract_id": "24601857", "label": "results", "text": "Seventeen were assigned to the SALT group with an overall triage accuracy of @ % @ % , an overtriage mean rate of @ @ % , and an undertriage rate of @ @ % .", "sentence_id": 12}
+{"abstract_id": "24601857", "label": "results", "text": "Twenty-six participants were assigned to the JumpSTART group with an overall accuracy of @ @ % , an overtriage mean of @ @ % , and an undertriage rate of @ @ % .", "sentence_id": 13}
+{"abstract_id": "24601857", "label": "results", "text": "Ease of use was not statistically different between the two systems ( median Likert value of both systems = @ , p = @ ) Time to triage per patient was statistically faster in the JumpSTART group ( SALT = @ @ seconds , JumpSTART = @ @ seconds , p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24601857", "label": "results", "text": "Both systems were prone to cognitive and affective error .", "sentence_id": 15}
+{"abstract_id": "24601857", "label": "conclusions", "text": "SALT appears to be at least as good as JumpSTART in overall triage accuracy , overtriage , or undertriage rates in a simulated pediatric MCI .", "sentence_id": 16}
+{"abstract_id": "24601857", "label": "conclusions", "text": "Both systems were considered easy to use .", "sentence_id": 17}
+{"abstract_id": "24601857", "label": "conclusions", "text": "However , JumpSTART was @ seconds faster per patient in time taken to assign triage designations .", "sentence_id": 18}
+{"abstract_id": "25876348", "label": "objective", "text": "To explore the clinical efficacy and effect mechanism on chronic urticaria treated with moving cupping therapy combined with autohemotherapy with acupaint injection for desensitization at acupoints .", "sentence_id": 0}
+{"abstract_id": "25876348", "label": "methods", "text": "One hundred and four patients of chronic urticaria were randomized into a comprehensive therapy group and a medication group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25876348", "label": "methods", "text": "In the comprehensive therapy group , the moving cupping therapy along the governor vessel and bladder meridian of foot-taiyang was applied combined with autohemotherapy with acupaint injection for desensitization at acupoints .", "sentence_id": 2}
+{"abstract_id": "25876348", "label": "methods", "text": "The self-venous blood was injected at bilateral Quchi ( LI @ ) and Zusanli ( ST @ ) , @ mL at each acupoint , once every @ days .", "sentence_id": 3}
+{"abstract_id": "25876348", "label": "methods", "text": "In the medication group , cetirizine tablets , @ mg were prescribed for oral administration , once every day , and the compound dexamethasone acetate cream was used externally , once to twice a day .", "sentence_id": 4}
+{"abstract_id": "25876348", "label": "methods", "text": "The clinical efficacy : was observed in @ days of treatment in the two groups .", "sentence_id": 5}
+{"abstract_id": "25876348", "label": "methods", "text": "The changes of serum interleukin @ ( IL-@ ) and immunoglobulin E ( Ig E ) before and after treatment were observed .", "sentence_id": 6}
+{"abstract_id": "25876348", "label": "methods", "text": "The recurrence rate was compared between the two groups in @ months after treatment .", "sentence_id": 7}
+{"abstract_id": "25876348", "label": "results", "text": "The cured and markedly effective rate was @ % ( @/@ ) in the comprehensive therapy group , which was higher obviously than @ % ( @/@ , P < @ ) in the medication group .", "sentence_id": 8}
+{"abstract_id": "25876348", "label": "results", "text": "The levels of serum IL-@ and IgE were reduced in the patients of the two groups , indicating the significant difference in comparison before and after treatment ( all P < @ ) and the reducing degree in the comprehensive therapy group was much more significant than that in the medicine group ( both P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25876348", "label": "results", "text": "The recurrence rate was @ % ( @/@ ) in the comprehensive therapy group in the @-month follow-up after treatment , and apparently lower than @ % ( @/@ , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25876348", "label": "conclusions", "text": "The moving cupping therapy combined with autohemotherapy with acupaint injection for desensitization at acupoints achieves the better efficacy on chronic urticaria compared with the routine western medicine treatment and the recurrence rate is low .", "sentence_id": 11}
+{"abstract_id": "25876348", "label": "conclusions", "text": "The effect mechanism is possibly related to the down-regulation of serum IL-@ and IgE in the patients .", "sentence_id": 12}
+{"abstract_id": "24469141", "label": "objective", "text": "To investigate the education effect of case-based learning ( CBL ) pattern on clinical internship of conservative dentistry and endodontics .", "sentence_id": 0}
+{"abstract_id": "24469141", "label": "methods", "text": "Forty-one undergraduates were randomly assigned into CBL group and traditional teaching group .", "sentence_id": 1}
+{"abstract_id": "24469141", "label": "methods", "text": "After clinical internship in the department of conservative dentistry and endodontics for @ weeks , each student in the @ groups underwent comprehensive examinations including medical record writing , case analysis , academic knowledge , professional skills and the ability of winning the trust of the patients .", "sentence_id": 2}
+{"abstract_id": "24469141", "label": "methods", "text": "The scores were compared between the @ groups using SPSS @ software package .", "sentence_id": 3}
+{"abstract_id": "24469141", "label": "results", "text": "There was no significant difference between the @ groups with regard to the scores of academic knowledge and profession skills ( P > @ ) .", "sentence_id": 4}
+{"abstract_id": "24469141", "label": "results", "text": "However , the results of medical record writing , case analysis and the ability of winning the trust of the patients showed significant difference between the @ groups ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24469141", "label": "conclusions", "text": "Proper application of CBL in clinical internship of conservative dentistry and endodontics contributes to improve students ' ability of clinical thinking , synthetical analysis and adaptability to different patients .", "sentence_id": 6}
+{"abstract_id": "25016303", "label": "background", "text": "People with dementia living in care homes often have complex mental health problems , disabilities and social needs .", "sentence_id": 0}
+{"abstract_id": "25016303", "label": "background", "text": "Providing more comprehensive training for staff working in care home environments is a high national priority .", "sentence_id": 1}
+{"abstract_id": "25016303", "label": "background", "text": "It is important that this training is evidence based and delivers improvement for people with dementia residing in these environments .", "sentence_id": 2}
+{"abstract_id": "25016303", "label": "background", "text": "Well-being and Health for People with Dementia ( WHELD ) combines the most effective elements of existing approaches to develop a comprehensive but practical staff training intervention .", "sentence_id": 3}
+{"abstract_id": "25016303", "label": "background", "text": "This optimised intervention is based on a factorial study and qualitative evaluation , to combine : training on person-centred care , promoting person-centred activities and interactions , and providing care home staff and general practitioners with updated knowledge regarding the optimal use of psychotropic medications for persons with dementia in care homes .", "sentence_id": 4}
+{"abstract_id": "25016303", "label": "methods", "text": "The trial will be a randomised controlled two-arm cluster single blind trial that will take place for nine months across @ care homes in the United Kingdom .", "sentence_id": 5}
+{"abstract_id": "25016303", "label": "conclusions", "text": "The overarching goal of this trial is to determine whether this optimised WHELD intervention is more effective in improving the quality of life and mental health than the usual care provided to people with dementia living in nursing homes .", "sentence_id": 6}
+{"abstract_id": "25016303", "label": "conclusions", "text": "This study will be the largest and best powered randomised controlled trial ( RCT ) evaluating the benefits of an augmented person-centred care training intervention in care homes worldwide .", "sentence_id": 7}
+{"abstract_id": "26237979", "label": "objective", "text": "To observe the clinical effect of slow-rapid reinforcing-reducing needling manipulation at Jiaji ( EX-B @ ) acupoint for lumbar intervertebral disc protrusion .", "sentence_id": 0}
+{"abstract_id": "26237979", "label": "methods", "text": "Sixty subjects met the inclusion criteria of disc herniation were randomly divided into treatment group ( n = @ ) and control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "26237979", "label": "methods", "text": "In the treatment group , the stimulation mode ( slow or fast , reinforcement or reduction ) of Jiaji acupoints ( EX-B @ ) was based on the status of the patients by an overall analysis of symptoms and signs .", "sentence_id": 2}
+{"abstract_id": "26237979", "label": "methods", "text": "Other acupoints such as Huantiao ( GB @ ) , Weizhong ( BL @ ) , etc. were stimulated with uniform reinforcing-reducing manipulation .", "sentence_id": 3}
+{"abstract_id": "26237979", "label": "methods", "text": "In the control group , all the acupoints were stimulated in uniform reinforcing-reducing mode .", "sentence_id": 4}
+{"abstract_id": "26237979", "label": "methods", "text": "The treatment was conducted once a day , continuously for @ days with @ day 's break between every @ days .", "sentence_id": 5}
+{"abstract_id": "26237979", "label": "methods", "text": "The clinical efficacy appraisal , visual analogue scale ( VAS ) and Japanese orthopaedic association ( JOA ) scores and traditional Chinese medicine ( TCM ) syndrome scores were used for outcome assessment .", "sentence_id": 6}
+{"abstract_id": "26237979", "label": "results", "text": "In comparison with pretreatment , the VAS scores and TCM syndrome scores were significantly decreased in both control and treatment groups ( P < @ ) , and the JOA scores were markedly increased after the treatment ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26237979", "label": "results", "text": "The therapeutic effects of the treatment group were obviously superior to those of the control group in down-regulating the VAS score and TCM syndome score and up-regulating JOA score ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "26237979", "label": "conclusions", "text": "Slow-fast reinforcing-reducing needling manipulation is superior to the routine acupuncture in the management of lumbar intervertebral disc protrusion .", "sentence_id": 9}
+{"abstract_id": "24527853", "label": "background", "text": "There are limited clinical experiments addressing the effects of photodynamic therapy ( PDT ) as an adjunct to conventional scaling and root planing ( SRP ) on clinical and biologic features of periodontitis .", "sentence_id": 0}
+{"abstract_id": "24527853", "label": "background", "text": "This trial compares the clinical parameters and cytokine profiles in gingival crevicular fluid of patients with moderate-to-severe chronic periodontitis ( CP ) who have been treated using SRP alone or SRP + PDT .", "sentence_id": 1}
+{"abstract_id": "24527853", "label": "methods", "text": "Twenty-two patients with two contralateral teeth affected with moderate-to-severe CP were selected .", "sentence_id": 2}
+{"abstract_id": "24527853", "label": "methods", "text": "After SRP , the participants ' teeth were randomized to receive either no further treatment or a single application of PDT using a @-nm laser and toluidine blue .", "sentence_id": 3}
+{"abstract_id": "24527853", "label": "methods", "text": "Although the change in probing depth was the primary outcome , bleeding on probing , clinical attachment level , gingival recession , interleukin-@ , tumor necrosis factor ( TNF ) - , and matrix metalloproteinase @ and @ were also evaluated at baseline and @ months postintervention .", "sentence_id": 4}
+{"abstract_id": "24527853", "label": "methods", "text": "An oral rinse assay was also performed to determine the total levels of oral polymorphonuclear cells ( PMNs ) before and @ months after the treatments .", "sentence_id": 5}
+{"abstract_id": "24527853", "label": "results", "text": "Within each group , significant improvements ( P < @ ) were found for all variables in @-month follow-up compared with baseline .", "sentence_id": 6}
+{"abstract_id": "24527853", "label": "results", "text": "Only TNF - was significantly improved in the PDT + SRP versus SRP group .", "sentence_id": 7}
+{"abstract_id": "24527853", "label": "results", "text": "Total levels of PMNs were reduced for all patients compared with baseline levels ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24527853", "label": "conclusions", "text": "In patients with CP , a single application of PDT ( using a @-nm laser and toluidine blue ) did not provide any additional benefit to SRP in terms of clinical parameters or inflammatory markers @ months following the intervention .", "sentence_id": 9}
+{"abstract_id": "24565123", "label": "objective", "text": "The combination of ketamine and remifentanil seems to be associated with better analgesia and duration .", "sentence_id": 0}
+{"abstract_id": "24565123", "label": "objective", "text": "The aim of this study was to evaluate whether a ketamine - remifentanil combination promotes improved postoperative analgesia .", "sentence_id": 1}
+{"abstract_id": "24565123", "label": "methods", "text": "Prospective , randomized , double blind study of @ patients undergoing video laparoscopic cholecystectomy .", "sentence_id": 2}
+{"abstract_id": "24565123", "label": "methods", "text": "Anesthesia was performed with remifentanil , propofol , atracurium , and @ % oxygen .", "sentence_id": 3}
+{"abstract_id": "24565123", "label": "methods", "text": "Group @ ( GI ) patients received remifentanil ( @ mcg.kg ( -@ ) .", "sentence_id": 4}
+{"abstract_id": "24565123", "label": "methods", "text": "min ( -@ ) ) and ketamine ( @ mcg.kg ( -@ ) .", "sentence_id": 5}
+{"abstract_id": "24565123", "label": "methods", "text": "min ( -@ ) ) and Group @ ( G@ ) received remifentanil ( @ mcg.kg ( -@ ) .", "sentence_id": 6}
+{"abstract_id": "24565123", "label": "methods", "text": "min ( -@ ) ) and saline solution .", "sentence_id": 7}
+{"abstract_id": "24565123", "label": "methods", "text": "Morphine @ mg.kg ( -@ ) was administered at the end of the procedure , and postoperative pain was treated with morphine via PCA .", "sentence_id": 8}
+{"abstract_id": "24565123", "label": "methods", "text": "We evaluated the severity of postoperative pain by a numerical scale from zero to @ during @ hours .", "sentence_id": 9}
+{"abstract_id": "24565123", "label": "methods", "text": "We registered the time to the first analgesic supplementation , amount of morphine used in the first @ hours , and adverse effects .", "sentence_id": 10}
+{"abstract_id": "24565123", "label": "results", "text": "There was a decrease in pain severity between extubation and other times evaluated in G@ and G@ .", "sentence_id": 11}
+{"abstract_id": "24565123", "label": "results", "text": "There was no significant difference in pain intensity between the groups .", "sentence_id": 12}
+{"abstract_id": "24565123", "label": "results", "text": "There was no difference between G@ ( @ @ min ) and G@ ( @ @ min ) regarding time to first dose of morphine and dose supplement of morphine consumed in G@ ( @ @ mg ) and G@ ( @ @ mg ) .", "sentence_id": 13}
+{"abstract_id": "24565123", "label": "conclusions", "text": "The combination of ketamine ( @ mcg.kg ( -@ ) .", "sentence_id": 14}
+{"abstract_id": "24565123", "label": "conclusions", "text": "min ( -@ ) ) and remifentanil ( @ mcg.kg ( -@ ) .", "sentence_id": 15}
+{"abstract_id": "24565123", "label": "conclusions", "text": "min ( -@ ) ) for cholecystectomy did not alter the severity of postoperative pain , time to first analgesic supplementation or dose of morphine in @ hours .", "sentence_id": 16}
+{"abstract_id": "24812898", "label": "objective", "text": "To observe the efficacy of integrative medical sequential method in treating cerebral palsy ( CP ) children 's intelligence development , muscular tension , serum interleukin @ ( IL-@ ) , and tumor necrosis factor alpha ( TNF-alpha ) .", "sentence_id": 0}
+{"abstract_id": "24812898", "label": "methods", "text": "Totally @ CP children were randomly assigned to the control group ( @ cases ) and the treatment group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24812898", "label": "methods", "text": "All patients received comprehensive rehabilitation training and intravenous dripping of Monosialotetrahexosylganglioside Sodium Injection for @ days .", "sentence_id": 2}
+{"abstract_id": "24812898", "label": "methods", "text": "But those in the treatment group additionally received Chinese medical enema for brain resuscitation , relieving rigidity of muscles and activating collaterals for @ days .", "sentence_id": 3}
+{"abstract_id": "24812898", "label": "methods", "text": "Then they started another medication cycle and lasted for a total of @ cycles .", "sentence_id": 4}
+{"abstract_id": "24812898", "label": "methods", "text": "Serum IL-@ levels and TNF-alpha contents were determined before treatment .", "sentence_id": 5}
+{"abstract_id": "24812898", "label": "methods", "text": "Scoring for muscular tension , Gesell score for intelligence development , contents of serum IL-@ and TNF-alpha were assessed before and after treatment in the two groups .", "sentence_id": 6}
+{"abstract_id": "24812898", "label": "results", "text": "Compared with before treatment in this group , muscular tension , Gesell scores for intelligence development all decreased in the two groups ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24812898", "label": "results", "text": "As for inter-group comparison , the decrement was more obvious in the treatment group than in the control group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24812898", "label": "results", "text": "The total effective rate was @ % in the treatment group and @ % in the control group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24812898", "label": "results", "text": "The contents of IL-@ and TNF-alpha were obviously reduced in the treatment group and the control group after treatment ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24812898", "label": "results", "text": "The decrement was more obvious in the treatment group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24812898", "label": "conclusions", "text": "The two treatment methods were effective for CP children , but the efficacy was superior in the treatment group than in the control group , indicating integrative medical methods could play a synergistic effect and optimize the treatment program for CP .", "sentence_id": 12}
+{"abstract_id": "25879524", "label": "background", "text": "A post-hoc analysis was performed on the data from a @weeks phase III study ( ClinicalTrials.gov identifier : NCT@ ) to measure changes in the health-related quality of life ( HRQoL ) of @,@ patients aged @ with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide ( OLM/AML/HCTZ ) , using the MINICHAL and EQ-@D instruments .", "sentence_id": 0}
+{"abstract_id": "25879524", "label": "methods", "text": "Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period .", "sentence_id": 1}
+{"abstract_id": "25879524", "label": "methods", "text": "Analysis of covariance ( ANCOVA ) was used to identify those factors that could possibly have influenced HRQoL .", "sentence_id": 2}
+{"abstract_id": "25879524", "label": "methods", "text": "Linear regression was used to assess the relationship between changes in blood pressure and HRQoL scores .", "sentence_id": 3}
+{"abstract_id": "25879524", "label": "results", "text": "Patients ' baseline MINICHAL mood and somatic domains scores were @ and @ .", "sentence_id": 4}
+{"abstract_id": "25879524", "label": "results", "text": "Over the study period HRQoL improved as both MINICHAL scores decreased by @-@ % .", "sentence_id": 5}
+{"abstract_id": "25879524", "label": "results", "text": "Patients ' baseline EQ-@D index and VAS scores were @ and @ respectively , increasing by @ % and @ % over the study period .", "sentence_id": 6}
+{"abstract_id": "25879524", "label": "results", "text": "Patients ' QALY gain over the @weeks study period was estimated to be @ QALYs .", "sentence_id": 7}
+{"abstract_id": "25879524", "label": "results", "text": "The ANCOVA showed that changes in patients ' HRQoL was likely to have been influenced by patients ' achievement of blood pressure control , the amount of concomitant medication and patients ' last used dosage strength of antihypertensive .", "sentence_id": 8}
+{"abstract_id": "25879524", "label": "results", "text": "Linear regression showed that blood pressure improvement may have been associated with improved HRQoL .", "sentence_id": 9}
+{"abstract_id": "25879524", "label": "conclusions", "text": "This study showed that OLM/AML/HCTZ reduced blood pressure and significantly increased blood pressure control whilst improving patients ' HRQoL .", "sentence_id": 10}
+{"abstract_id": "25879524", "label": "conclusions", "text": "Achieving blood pressure control , amount of concomitant medication and dosage strength of antihypertensive impacted on patients ' HRQoL .", "sentence_id": 11}
+{"abstract_id": "24583820", "label": "background", "text": "The effect of anaesthetic drugs on long-term oncological outcomes after cancer surgery is an area of current interest .", "sentence_id": 0}
+{"abstract_id": "24583820", "label": "background", "text": "Dexamethasone is widely used in anaesthetic practice ; however , its effect on long-term survival and cancer outcomes is not known .", "sentence_id": 1}
+{"abstract_id": "24583820", "label": "background", "text": "This study presents the results of a @-yr follow-up of patients receiving dexamethasone before elective colectomy as part of a previous randomized clinical trial .", "sentence_id": 2}
+{"abstract_id": "24583820", "label": "methods", "text": "Sixty patients who underwent elective open colonic resection for any indication between June @ and March @ were randomized to receive either @ mg i.v. dexamethasone or placebo before surgery .", "sentence_id": 3}
+{"abstract_id": "24583820", "label": "methods", "text": "A @-yr follow-up analysis was conducted to evaluate overall survival , disease-free survival and recurrence specifically for patients undergoing resection for Stage I-III colon cancer .", "sentence_id": 4}
+{"abstract_id": "24583820", "label": "methods", "text": "Kaplan-Meier analysis was performed and log-rank test was used to evaluate difference in survival between groups .", "sentence_id": 5}
+{"abstract_id": "24583820", "label": "results", "text": "Forty-three of the @ subjects had Stage I-III colon cancer and were included in the follow-up analysis .", "sentence_id": 6}
+{"abstract_id": "24583820", "label": "results", "text": "Twenty received preoperative dexamethasone and @ received placebo .", "sentence_id": 7}
+{"abstract_id": "24583820", "label": "results", "text": "There were no significant differences between groups in baseline or disease characteristics .", "sentence_id": 8}
+{"abstract_id": "24583820", "label": "results", "text": "No differences were found between groups for overall or disease-free survival .", "sentence_id": 9}
+{"abstract_id": "24583820", "label": "results", "text": "In the dexamethasone group , there was a significantly higher rate of distant recurrence ( @ compared with @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24583820", "label": "conclusions", "text": "Preoperative dexamethasone was associated with a higher rate of distant recurrence in patients undergoing colectomy for colon cancer .", "sentence_id": 11}
+{"abstract_id": "24583820", "label": "conclusions", "text": "Given the small sample size , this finding should be interpreted with caution , but warrants further investigation in a prospective study .", "sentence_id": 12}
+{"abstract_id": "24432712", "label": "background", "text": "The EXAcerbations of Chronic Pulmonary Disease Tool ( EXACT ) is a patient-reported outcome measure to standardize the symptomatic assessment of chronic obstructive pulmonary disease exacerbations , including reported and unreported events .", "sentence_id": 0}
+{"abstract_id": "24432712", "label": "background", "text": "The instrument has been validated in a short-term study of patients with acute exacerbation and stable disease ; its performance in longer-term studies has not been assessed .", "sentence_id": 1}
+{"abstract_id": "24432712", "label": "objective", "text": "To test the EXACT 's performance in three randomized controlled trials and describe the relationship between resource-defined medically treated exacerbations ( MTEs ) and symptom ( EXACT ) - defined events .", "sentence_id": 2}
+{"abstract_id": "24432712", "label": "methods", "text": "Prespecified secondary analyses of data from phase II randomized controlled trials testing new drugs for the management of chronic obstructive pulmonary disease : one @-month trial ( United States ) ( n = @ ) and two @-month , multinational trials ( AZ @ -LSB- n = @ -RSB- , AZ @ -LSB- n = @ -RSB- ) .", "sentence_id": 3}
+{"abstract_id": "24432712", "label": "methods", "text": "In each case , the experimental drugs were found to be ineffective , permitting assessment of the EXACT 's performance in three independent studies of moderate to severe high-risk patients on maintenance therapies .", "sentence_id": 4}
+{"abstract_id": "24432712", "label": "results", "text": "The mean age of subjects was @ to @ years ; @ to @ % were male .", "sentence_id": 5}
+{"abstract_id": "24432712", "label": "results", "text": "Mean FEV@ % predicted was @ to @ % .", "sentence_id": 6}
+{"abstract_id": "24432712", "label": "results", "text": "EXACT scores exhibited internal consistency ( Cronbach 's @ ) , reproducibility ( intraclass correlation @ ) , correlation with St. George 's Respiratory Questionnaire ( Spearman rho -LSB- rs -RSB- = @ , @ , @ in the three trials ; P < @ ) , and Breathlessness Cough and Sputum Scale ( AZ @ , rs = @ ; AZ @ , rs = @ ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24432712", "label": "results", "text": "EXACT-defined events had a high correspondence with alternative indicators of worsening ( @ , @ , and @ % ) .", "sentence_id": 8}
+{"abstract_id": "24432712", "label": "results", "text": "In each trial , unreported events were similar in severity ( mean EXACT score , @ , @ , @ vs. @ , @ -LSB- P < @ -RSB- , @ -LSB- P < @ -RSB- , respectively ; @-point scale ) and longer ( median , @ , @ , @ vs. @ , @ -LSB- P < @ -RSB- , @ days , respectively ) than moderate MTEs .", "sentence_id": 9}
+{"abstract_id": "24432712", "label": "conclusions", "text": "Data generated through the EXACT offers insight into the symptomatic nature of MTEs and the frequency , severity , and duration of unreported symptom-defined events .", "sentence_id": 10}
+{"abstract_id": "24432712", "label": "conclusions", "text": "Clinical trials registered with www.clinicaltrials.gov ( MPEX : NCT@ ; AZ @ : NCT@ ; AZ @ : NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24621686", "label": "background", "text": "Complex regional pain syndrome is multifactorial .", "sentence_id": 0}
+{"abstract_id": "24621686", "label": "background", "text": "Exaggerated inflammatory responses to limb injury may be involved .", "sentence_id": 1}
+{"abstract_id": "24621686", "label": "background", "text": "The authors hypothesized that capsaicin-induced pain and neurogenic inflammation ( skin perfusion and flare area ) are increased in patients with complex regional pain syndrome compared with that in controls .", "sentence_id": 2}
+{"abstract_id": "24621686", "label": "methods", "text": "Twenty patients with unilateral upper-limb complex regional pain syndrome and @ age - , sex - , and body mass index-matched controls participated .", "sentence_id": 3}
+{"abstract_id": "24621686", "label": "methods", "text": "Topical capsaicin @ % was applied to the back of both hands for @ min , and pain intensity was assessed on a visual analogue scale .", "sentence_id": 4}
+{"abstract_id": "24621686", "label": "methods", "text": "A laser Doppler perfusion imager scanner estimated capsaicin-induced skin perfusion and flare area .", "sentence_id": 5}
+{"abstract_id": "24621686", "label": "methods", "text": "Autonomic and small-fiber function was assessed by sensory testing , quantitative sudomotor axon reflex test , and vasoconstrictor responses .", "sentence_id": 6}
+{"abstract_id": "24621686", "label": "results", "text": "The authors found bilateral hypersensitivity to capsaicin ( P @ ) , skin fold ( P = @ ) , joint pressure ( P < @ ) , cold ( P @ ) , and heat pain ( P @ ) in patients compared with that in controls and thermal and mechanical hyperalgesia in the complex regional pain syndrome-affected hand compared with that in the unaffected hand ( P @ ) .", "sentence_id": 7}
+{"abstract_id": "24621686", "label": "results", "text": "The patients had normal capsaicin-induced flare areas , thermal detection thresholds , quantitative sudomotor axon reflex test , and vasoconstrictor responses .", "sentence_id": 8}
+{"abstract_id": "24621686", "label": "conclusions", "text": "The main finding is bilaterally increased capsaicin-induced pain in patients compared with controls .", "sentence_id": 9}
+{"abstract_id": "24621686", "label": "conclusions", "text": "The flare response to capsaicin was normal , suggesting that the increased pain response was not due to increased neurogenic inflammation .", "sentence_id": 10}
+{"abstract_id": "24621686", "label": "conclusions", "text": "The bilateral hypersensitivity to painful chemical , thermal , and mechanical stimuli not confined to the innervation area of a peripheral nerve or root can not be explained by a regional change and may partly be due to central sensitization .", "sentence_id": 11}
+{"abstract_id": "25037883", "label": "background", "text": "Diurnal variation in serum growth hormone ( s-GH ) levels after exogenous GH delivery has previously been reported in patients with no endogenous GH secretion .", "sentence_id": 0}
+{"abstract_id": "25037883", "label": "background", "text": "Changes in postural position or physical activity , leading to changes in blood flow and/or lymphatic drainage may be underlying explanations .", "sentence_id": 1}
+{"abstract_id": "25037883", "label": "objective", "text": "The primary aim of this study is to study a possible impact of exercise and supine rest on pharmacokinetics ( PK ) and day-to-day variation of subcutaneously ( s.c. ) administered GH in adult GH deficient ( AGHD ) patients .", "sentence_id": 2}
+{"abstract_id": "25037883", "label": "objective", "text": "The secondary aim of this study is to compare s-IGF-I , s-insulin , and plasma ( p ) - glucose profiles after a carbohydrate rich breakfast following s.c. GH injection vs. continuous infusion .", "sentence_id": 3}
+{"abstract_id": "25037883", "label": "methods", "text": "During supine rest eight AGHD males ( @ years , BMI @ kg/m ( @ ) ) were treated with one daily s.c. GH injections of @ mg/@ h for @ h ( treatment sessions A , B ) or a continuous s.c. GH infusion of @ mg/@ h for @ h ( treatment sessions C , D ) .", "sentence_id": 4}
+{"abstract_id": "25037883", "label": "methods", "text": "Exercise comprised @ h bicycling with @ W load on two consecutive days during treatment sessions B and D.", "sentence_id": 5}
+{"abstract_id": "25037883", "label": "results", "text": "Administration of GH as a bolus injection , but not as a continuous GH infusion , resulted in about @ % higher s-GH levels during exercise ( @ min ) as well as @ min after ( s-GH logAUC ( B-A ) difference was @ ; @ % CI : @-@ @ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25037883", "label": "results", "text": "However , the total s-GH ( AUC @-@ h ) ( p = @ ) and s-IGF-I ( AUC@-@ h ) levels ( p = @ ) remained unchanged between the two occasions .", "sentence_id": 7}
+{"abstract_id": "25037883", "label": "results", "text": "P-glucose and insulin profiles were significantly higher after carbohydrate rich breakfast before first and second dosing both following s.c. GH injection and continuous infusion ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25037883", "label": "conclusions", "text": "Moderate exercise intermittently increased s-GH levels .", "sentence_id": 9}
+{"abstract_id": "25037883", "label": "conclusions", "text": "These changes seem to have no clinical short-term relevance , since total s-GH ( @ h ) and s-IGF-I ( @ h ) levels were unaffected .", "sentence_id": 10}
+{"abstract_id": "24420155", "label": "objective", "text": "The purpose of this prospective , randomised study was to evaluate long-term clinical results , radiographic findings , complications and revision and survivorship rates in patients < @ years at a minimum of @ years after undergoing bilateral , sequential , simultaneous , cemented and cementless total knee arthroplasties ( TKAs ) in the same patients .", "sentence_id": 0}
+{"abstract_id": "24420155", "label": "methods", "text": "Bilateral , sequential , simultaneous TKAs were performed in @ patients ( @ knees ) .", "sentence_id": 1}
+{"abstract_id": "24420155", "label": "methods", "text": "There were @ women and @ men with a mean age of @ years ( range @-@ ) , who received a cementless prosthesis in one knee and a cemented prosthesis in the other .", "sentence_id": 2}
+{"abstract_id": "24420155", "label": "methods", "text": "The mean follow-up was @ years ( range @-@ ) .", "sentence_id": 3}
+{"abstract_id": "24420155", "label": "results", "text": "At final review , the mean Knee Society ( KS ) knee scores ( @ versus @ ) , Western Ontario and McMaster Universities ( WOMAC ) osteoarthritis ( OA ) index ( @ versus @ ) , range of motion ( ROM ) ( @ versus @ ) , patient satisfaction ( @ versus @ ) and radiological results were similar in both groups .", "sentence_id": 4}
+{"abstract_id": "24420155", "label": "results", "text": "Femoral component survival rate was @ % in both groups at @ years ; at @ years , the cemented tibial component survival rate was @ % and the cementless tibial component @ % .", "sentence_id": 5}
+{"abstract_id": "24420155", "label": "results", "text": "No osteolysis was identified in either group .", "sentence_id": 6}
+{"abstract_id": "24420155", "label": "conclusions", "text": "Long-term results of both cementless and cemented TKAs were encouraging in patients with OA who were < @ years .", "sentence_id": 7}
+{"abstract_id": "24420155", "label": "conclusions", "text": "However , we found no evidence to prove the superiority of cementless over cemented TKAs .", "sentence_id": 8}
+{"abstract_id": "25022777", "label": "objective", "text": "To assess the relationship between session-by-session mediators and treatment outcomes in traditional cognitive-behavioral therapy ( CBT ) and acceptance and commitment therapy ( ACT ) for social anxiety disorder .", "sentence_id": 0}
+{"abstract_id": "25022777", "label": "methods", "text": "Session-by-session changes in negative cognitions ( a theorized mediator of CBT ) and experiential avoidance ( a theorized mediator of ACT ) were assessed in @ adult outpatients randomized to CBT ( n = @ ) or ACT ( n = @ ) for DSM-IV social anxiety disorder .", "sentence_id": 1}
+{"abstract_id": "25022777", "label": "results", "text": "Multilevel modeling analyses revealed significant nonlinear decreases in the proposed mediators in both treatments , with ACT showing steeper decline than CBT at the beginning of treatment and CBT showing steeper decline than ACT at the end of treatment .", "sentence_id": 2}
+{"abstract_id": "25022777", "label": "results", "text": "Curvature ( or the nonlinear effect ) of experiential avoidance during treatment significantly mediated posttreatment social anxiety symptoms and anhedonic depression in ACT , but not in CBT , with steeper decline of the Acceptance and Action Questionnaire at the beginning of treatment predicting fewer symptoms in ACT only .", "sentence_id": 3}
+{"abstract_id": "25022777", "label": "results", "text": "Curvature of negative cognitions during both treatments predicted outcome , with steeper decline of negative cognitions at the beginning of treatment predicting lower posttreatment social anxiety and depressive symptoms .", "sentence_id": 4}
+{"abstract_id": "25022777", "label": "conclusions", "text": "Rate of change in negative cognitions at the beginning of treatment is an important predictor of change across both ACT and CBT , whereas rate of change in experiential avoidance at the beginning of treatment is a mechanism specific to ACT .", "sentence_id": 5}
+{"abstract_id": "25011612", "label": "background", "text": "Although the benefits of physical activity ( PA ) on to prevent and manage non-communicable diseases are well known , strategies to help increase the levels of PA among different populations are limited .", "sentence_id": 0}
+{"abstract_id": "25011612", "label": "background", "text": "Exercise-referral schemes have emerged as one effective approach to promote PA ; however , there is uncertainty about the feasibility and effectiveness of these schemes in settings outside high-income countries .", "sentence_id": 1}
+{"abstract_id": "25011612", "label": "background", "text": "This study will examine the effectiveness of a scheme to refer hypertensive patients identified in Primary Health Care facilities ( PHCU ) of the Mexican social security institution to a group PA program offered in the same institution .", "sentence_id": 2}
+{"abstract_id": "25011612", "label": "methods", "text": "We will describe the methods of a cluster randomized trial study designed to evaluate the effectiveness of an exercise referral scheme to increasing physical activity in hypertensive patients compared to a non-referral scheme .", "sentence_id": 3}
+{"abstract_id": "25011612", "label": "methods", "text": "Four PHCU were selected for the study ; the PHCU will take part as the unit of randomization and sedentary hypertensive patients as the unit of assessment .", "sentence_id": 4}
+{"abstract_id": "25011612", "label": "methods", "text": "@ PHCU of control group ( GC ) will provide information to hypertensive patients about physical activity benefits and ways to increase it safely .", "sentence_id": 5}
+{"abstract_id": "25011612", "label": "methods", "text": "@ PHCU of intervention group ( IG ) will refer patients to sports facilities at the same institution , to follow a group-based PA program developed to increase the PA levels with a designed based on the Transtheoretical Model and Social Cognitive Theory .", "sentence_id": 6}
+{"abstract_id": "25011612", "label": "methods", "text": "To evaluate the effects of the intervention as well as short-term maintenance of the intervention 's effects , PA will be assessed at baseline , at @ and @ weeks of follow-up .", "sentence_id": 7}
+{"abstract_id": "25011612", "label": "methods", "text": "The main outcome will be the difference before and after intervention in the percentage of participants meeting recommended levels of PA between and within intervention and control groups .", "sentence_id": 8}
+{"abstract_id": "25011612", "label": "methods", "text": "PA will be measured through self-report and with objective measure by accelerometer .", "sentence_id": 9}
+{"abstract_id": "25011612", "label": "conclusions", "text": "This study will allow us to evaluate a multidisciplinary effort to link the primary care and community-based areas of the same health care system .", "sentence_id": 10}
+{"abstract_id": "25011612", "label": "conclusions", "text": "Our findings will provide important information about the feasibility and effectiveness of an exercise-referral scheme and will be useful for decision-making about the implementation of strategies for increasing PA among hypertensive and other clinical populations in Mexico and Latin America .", "sentence_id": 11}
+{"abstract_id": "24719046", "label": "objective", "text": "Rheumatoid arthritis ( RA ) patients display high levels of oxidative stress .", "sentence_id": 0}
+{"abstract_id": "24719046", "label": "objective", "text": "Transient exercise-induced increases in oxidative stress are thought to be adaptive in healthy populations .", "sentence_id": 1}
+{"abstract_id": "24719046", "label": "objective", "text": "This study investigated the effect of exercise on markers of oxidative stress in RA , following acute exercise and a period of exercise training .", "sentence_id": 2}
+{"abstract_id": "24719046", "label": "methods", "text": "Acute exercise study : RA patients ( N = @ , age : @ ) undertook a bout of exercise ( @-@min , @ % VO@MAX ) , and blood samples were taken before and after exercise to assess markers of oxidative stress .", "sentence_id": 3}
+{"abstract_id": "24719046", "label": "methods", "text": "Training study : RA patients ( N = @ , age : @ ) were randomised into either a control or exercise group , who undertook @ exercise sessions per week ( @-@min @ @ % VO@MAX ) for @months .", "sentence_id": 4}
+{"abstract_id": "24719046", "label": "methods", "text": "Plasma markers of oxidative stress ( protein carbonyls ( PC ) , lipid hydroperoxides ( LOOH ) , @-nitrotyrosine ( @-NT ) , total antioxidant capacity ( TAC ) and catalase ( CAT ) activity ) , inflammation ( interleukin-@ ( IL-@ ) and C-reactive protein ( CRP ) ) and nitric oxide metabolites ( NOx ) were assessed before and after training .", "sentence_id": 5}
+{"abstract_id": "24719046", "label": "results", "text": "Acute exercise study : Protein carbonyls ( PC ) ( +@ % ) and NOx ( +@ % ) were significantly increased following exercise .", "sentence_id": 6}
+{"abstract_id": "24719046", "label": "results", "text": "Training study : @-nitrotyrosine ( @-NT ) decreased ( @ to @ M ) in the exercise group only , alongside increases in aerobic fitness ( @ to @ ml/kg/min ( -@ ) ) and reductions in disease activity score ( DAS : @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "24719046", "label": "results", "text": "PC , LOOH , TAC , IL-@ , CRP and NOx concentrations , and CAT activity were unchanged in both groups .", "sentence_id": 8}
+{"abstract_id": "24719046", "label": "conclusions", "text": "Aerobic exercise training did not increase markers of oxidative stress in RA patients .", "sentence_id": 9}
+{"abstract_id": "24719046", "label": "conclusions", "text": "@-Nitrotyrosine and disease activity were decreased following exercise training .", "sentence_id": 10}
+{"abstract_id": "25019632", "label": "background", "text": "The application of internet technology for telerehabilitation in patients with stroke has developed rapidly .", "sentence_id": 0}
+{"abstract_id": "25019632", "label": "objective", "text": "The current study aimed to evaluate the effect of a bidirectional and multi-user telerehabilitation system on balance and satisfaction in patients with chronic stroke living in long-term care facilities ( LTCFs ) .", "sentence_id": 1}
+{"abstract_id": "25019632", "label": "methods", "text": "This pilot study used a multi-site , blocked randomization design .", "sentence_id": 2}
+{"abstract_id": "25019632", "label": "methods", "text": "Twenty-four participants from three LTCFs were recruited , and the participants were randomly assigned into the telerehabilitation ( Tele ) and conventional therapy ( Conv ) groups within each LTCF .", "sentence_id": 3}
+{"abstract_id": "25019632", "label": "methods", "text": "Tele group received telerehabilitation but the Conv group received conventional therapy with two persons in each group for three sessions per week and for four weeks .", "sentence_id": 4}
+{"abstract_id": "25019632", "label": "methods", "text": "The outcome measures included Berg Balance Scale ( BBS ) , Barthel Index ( BI ) , and the telerehabilitation satisfaction of the participants .", "sentence_id": 5}
+{"abstract_id": "25019632", "label": "methods", "text": "A telerehabilitation system included `` therapist end '' in a laboratory , and the `` client end '' in LTCFs .", "sentence_id": 6}
+{"abstract_id": "25019632", "label": "methods", "text": "The conventional therapy was conducted in LTCFs .", "sentence_id": 7}
+{"abstract_id": "25019632", "label": "results", "text": "Training programs conducted for both the Tele and Conv groups showed significant effects within groups on the participant BBS as well as the total and self-care scores of BI .", "sentence_id": 8}
+{"abstract_id": "25019632", "label": "results", "text": "No significant difference between groups could be demonstrated .", "sentence_id": 9}
+{"abstract_id": "25019632", "label": "results", "text": "The satisfaction of participants between the Tele and the Conv groups also did not show significant difference .", "sentence_id": 10}
+{"abstract_id": "25019632", "label": "conclusions", "text": "This pilot study indicated that the multi-user telerehabilitation program is feasible for improving the balance and functional activity similar to conventional therapy in patients with chronic stroke living in LTCFs .", "sentence_id": 11}
+{"abstract_id": "24312382", "label": "background", "text": "The reward value of food is partly dependent on learned associations .", "sentence_id": 0}
+{"abstract_id": "24312382", "label": "background", "text": "It is not yet known whether replacing sugar with non-caloric sweeteners in food is affecting long-term acceptance .", "sentence_id": 1}
+{"abstract_id": "24312382", "label": "objective", "text": "To determine the effect of replacing sugar with non-caloric sweeteners in a nutrient-empty drink ( soft drink ) versus nutrient-rich drink ( yoghurt drink ) on reward value after repeated exposure .", "sentence_id": 2}
+{"abstract_id": "24312382", "label": "methods", "text": "We used a randomized crossover design whereby forty subjects ( @ men , @ women ) with a mean SD age of @ @ y and BMI of @ @ kg/m ( @ ) consumed a fixed portion of a non-caloric sweetened ( NS ) and sugar sweetened ( SS ) versions of either a soft drink or a yoghurt drink ( counterbalanced ) for breakfast which were distinguishable by means of colored labels .", "sentence_id": 3}
+{"abstract_id": "24312382", "label": "methods", "text": "Each version of a drink was offered @ times in semi-random order .", "sentence_id": 4}
+{"abstract_id": "24312382", "label": "methods", "text": "Before and after conditioning the reward value of the drinks was assessed using behavioral tasks on wanting , liking , and expected satiety .", "sentence_id": 5}
+{"abstract_id": "24312382", "label": "methods", "text": "In a subgroup ( n = @ ) fMRI was performed to assess brain reward responses to the drinks .", "sentence_id": 6}
+{"abstract_id": "24312382", "label": "results", "text": "Outcomes of both the behavioral tasks and fMRI showed that conditioning did not affect the reward value of the NS and SS versions of the drinks significantly .", "sentence_id": 7}
+{"abstract_id": "24312382", "label": "results", "text": "Overall , subjects preferred the yoghurt drinks to the soft drinks and the ss drinks to the NS drinks .", "sentence_id": 8}
+{"abstract_id": "24312382", "label": "results", "text": "In addition , they expected the yoghurt drinks to be more satiating , they reduced hunger more , and delayed the first eating episode more .", "sentence_id": 9}
+{"abstract_id": "24312382", "label": "results", "text": "Conditioning did not influence these effects .", "sentence_id": 10}
+{"abstract_id": "24312382", "label": "conclusions", "text": "Our study showed that repeated consumption of a non-caloric sweetened beverage , instead of a sugar sweetened version , appears not to result in changes in the reward value .", "sentence_id": 11}
+{"abstract_id": "24312382", "label": "conclusions", "text": "It can not be ruled out that learned associations between sensory attributes and food satiating capacity which developed preceding the conditioning period , during lifetime , affected the reward value of the drinks .", "sentence_id": 12}
+{"abstract_id": "24439713", "label": "objective", "text": "We test the hypothesis that anesthesia , measured as pain scores , induced by a novel topical anesthetic putty is non-inferior ( margin = @ ) to that provided by conventional lidocaine infiltration for the repair of lacerations .", "sentence_id": 0}
+{"abstract_id": "24439713", "label": "methods", "text": "A randomized controlled trial was conducted in the emergency department ( ED ) of a local hospital .", "sentence_id": 1}
+{"abstract_id": "24439713", "label": "methods", "text": "Participants were randomly allocated to receive either infiltration anesthesia or topical anesthetic putty as per the trial protocol .", "sentence_id": 2}
+{"abstract_id": "24439713", "label": "methods", "text": "Pain scores were recorded @ minutes after infiltration and @ minutes after topical anesthetic putty application .", "sentence_id": 3}
+{"abstract_id": "24439713", "label": "methods", "text": "Median pain scores were compared between groups .", "sentence_id": 4}
+{"abstract_id": "24439713", "label": "methods", "text": "Wound evaluation scores were conducted after @ to @ days and adverse events were monitored for both groups of participants throughout the study .", "sentence_id": 5}
+{"abstract_id": "24439713", "label": "results", "text": "One hundred and ten participants were enrolled in the study , with @ receiving infiltration and @ receiving topical anesthetic putty .", "sentence_id": 6}
+{"abstract_id": "24439713", "label": "results", "text": "The median difference between the pain scores of the @ groups was @ ( @ % confidence interval -@ to @ ) .", "sentence_id": 7}
+{"abstract_id": "24439713", "label": "results", "text": "There were no substantial differences between the @ groups in terms of either the wound evaluation scores or the incidence of adverse events .", "sentence_id": 8}
+{"abstract_id": "24439713", "label": "conclusions", "text": "The novel topical anesthetic putty was not inferior to infiltration with lidocaine with respect to the pain experienced during suturing , and this putty is a feasible alternative to infiltration anesthesia of lacerations in the ED .", "sentence_id": 9}
+{"abstract_id": "25529948", "label": "objective", "text": "To explore the value of preoperative evaluation with three-dimensional endoanal ultrasonography ( @D-EAUS ) for anal fistula in order to provide preoperative assessment for anal fistula .", "sentence_id": 0}
+{"abstract_id": "25529948", "label": "methods", "text": "One hundred patients diagnosed with anal fistula undergoing surgery between March @ and March @ in our department were prospectively enrolled .", "sentence_id": 1}
+{"abstract_id": "25529948", "label": "methods", "text": "All the patients were randomly divided into the ultrasound group and the control group with fifty patients in each group .", "sentence_id": 2}
+{"abstract_id": "25529948", "label": "methods", "text": "The ultrasound group received @D-EAUS and the control group received routine examinations ( digital examination and probe ) to assess the position of the internal opening , the type of fistula and secondary tracks , respectively .", "sentence_id": 3}
+{"abstract_id": "25529948", "label": "methods", "text": "The concordance rate of the preoperative assessment and intraoperative exploration was evaluated between the two groups .", "sentence_id": 4}
+{"abstract_id": "25529948", "label": "results", "text": "The accuracy of identifying internal opening was @ % for the ultrasound group and @ % for the control group with statistically significant difference ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25529948", "label": "results", "text": "The accuracy of identifying internal opening for simple anal fistula was similar ( @ % vs. @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25529948", "label": "results", "text": "For complex anal fistula , the accuracy was also higher in the ultrasound group ( @ % vs. @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25529948", "label": "results", "text": "The accuracy of fistula classification was @ % for the ultrasound group and @ % for the control group with significant difference ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25529948", "label": "results", "text": "The accuracy of identifying a second track was higher in the ultrasound group ( @ % vs. @ % , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25529948", "label": "conclusions", "text": "It is significantly superior for @D-EAUS to detect the internal opening , fistula classification and identification of a second track in complex anal fistulas as compared to conventional examination .", "sentence_id": 10}
+{"abstract_id": "25529948", "label": "conclusions", "text": "@D-EAUS should be recommended as a preoperative assessment for anal fistula , especially for complex one .", "sentence_id": 11}
+{"abstract_id": "26225442", "label": "objective", "text": "The quality of integrated diabetes care is important for reducing the burden of diabetes .", "sentence_id": 0}
+{"abstract_id": "26225442", "label": "objective", "text": "Therefore , we have evaluated the effect of a supervision program on the quality of integrated diabetes care in the Netherlands in the @-@ period .", "sentence_id": 1}
+{"abstract_id": "26225442", "label": "methods", "text": "In this cluster RCT , the supervision program was assigned to randomly selected care groups providing care to diabetes patients .", "sentence_id": 2}
+{"abstract_id": "26225442", "label": "methods", "text": "The supervision program included announcements of inspections , site visits , and sending individualized reports .", "sentence_id": 3}
+{"abstract_id": "26225442", "label": "methods", "text": "Indicators of effectiveness were derived from the structures , processes , and outcomes of care .", "sentence_id": 4}
+{"abstract_id": "26225442", "label": "methods", "text": "These indicators were collected from patients ' files , before and after the supervision program .", "sentence_id": 5}
+{"abstract_id": "26225442", "label": "methods", "text": "Hierarchical linear and logistic regression models were used to analyze data from @ patients of @ intervention and @ control care groups .", "sentence_id": 6}
+{"abstract_id": "26225442", "label": "results", "text": "Structures and processes of care did not improve more in the intervention groups than in the control care groups .", "sentence_id": 7}
+{"abstract_id": "26225442", "label": "results", "text": "Moreover , health outcomes did not improve more in the intervention groups than in the control care groups .", "sentence_id": 8}
+{"abstract_id": "26225442", "label": "results", "text": "Although structures of care improved over time in the total population of intervention and control care groups , there were no changes in process of care or health outcomes .", "sentence_id": 9}
+{"abstract_id": "26225442", "label": "conclusions", "text": "In this cluster RCT , we could not demonstrate improvements in quality of integrated diabetes care resulting from the supervision program .", "sentence_id": 10}
+{"abstract_id": "26225442", "label": "conclusions", "text": "Although structures of care did improve over time , other quality-improvement initiatives are necessary to substantially strengthen integrated care for diabetes patients .", "sentence_id": 11}
+{"abstract_id": "25807408", "label": "background", "text": "Following a major burn , skeletal muscle protein synthesis rate increases but is often insufficient to compensate for massively elevated muscle protein breakdown rates .", "sentence_id": 0}
+{"abstract_id": "25807408", "label": "background", "text": "Given the long-term nature of the pathophysiologic response to burn injury , we hypothesized that muscle protein synthesis rate would be chronically elevated in severely burned children .", "sentence_id": 1}
+{"abstract_id": "25807408", "label": "background", "text": "The objectives of this study were to characterize muscle protein synthesis rate of burned children over a period of @ months after injury and to identify predictors that influence this response .", "sentence_id": 2}
+{"abstract_id": "25807408", "label": "methods", "text": "A total of @ children with @ % or greater total body surface area ( TBSA ) burned were included .", "sentence_id": 3}
+{"abstract_id": "25807408", "label": "methods", "text": "Patients participated in stable isotope infusion studies at @ , @ , and approximately @ weeks after burn and at @ , @ , and @ months after injury to determine skeletal muscle protein fractional synthesis rate .", "sentence_id": 4}
+{"abstract_id": "25807408", "label": "methods", "text": "Generalized estimating equations with log link normal distribution were applied to account for clustering of patients and control for patient characteristics .", "sentence_id": 5}
+{"abstract_id": "25807408", "label": "results", "text": "Patients ( @ @ years ) had large ( @ , @-@ % TBSA ) and deep ( @ % @ % TBSA third degree ) burns .", "sentence_id": 6}
+{"abstract_id": "25807408", "label": "results", "text": "Muscle protein fractional synthesis rate was elevated throughout the first @ months after burn compared with established values from healthy young adults .", "sentence_id": 7}
+{"abstract_id": "25807408", "label": "results", "text": "Muscle protein fractional synthesis rate was lower in boys , in children older than @ years , and when burns were greater than @ % TBSA .", "sentence_id": 8}
+{"abstract_id": "25807408", "label": "conclusions", "text": "Muscle protein synthesis is elevated for at least @ year after injury , suggesting that greater muscle protein turnover is a component of the long-term pathophysiologic response to burn trauma .", "sentence_id": 9}
+{"abstract_id": "25807408", "label": "conclusions", "text": "Muscle protein synthesis is highly affected by sex , age , and burn size in severely burned children .", "sentence_id": 10}
+{"abstract_id": "25807408", "label": "conclusions", "text": "These findings may explain the divergence in net protein balance and lean body mass in different populations of burn patients .", "sentence_id": 11}
+{"abstract_id": "25807408", "label": "methods", "text": "Prognostic study , level III .", "sentence_id": 12}
+{"abstract_id": "25754845", "label": "background", "text": "In this study , we evaluated long-term survival in patients treated with and without mechanical bowel preparation ( MBP ) before colorectal surgery for cancer .", "sentence_id": 0}
+{"abstract_id": "25754845", "label": "methods", "text": "Long-term outcome of patients of @ main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed .", "sentence_id": 1}
+{"abstract_id": "25754845", "label": "methods", "text": "Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality .", "sentence_id": 2}
+{"abstract_id": "25754845", "label": "results", "text": "A total of @ patients underwent potentially curative surgery for colorectal cancer .", "sentence_id": 3}
+{"abstract_id": "25754845", "label": "results", "text": "One hundred seventy-seven ( @ % ) patients were treated with MBP and @ ( @ % ) were not before surgery .", "sentence_id": 4}
+{"abstract_id": "25754845", "label": "results", "text": "Median follow-up was @ years ( mean @ , range @ to @ ) .", "sentence_id": 5}
+{"abstract_id": "25754845", "label": "results", "text": "There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP ( P = @ and P = @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "25754845", "label": "results", "text": "Multivariate analysis , taking account of age , sex , AJCC cancer stage , and ASA classification , also showed no survival difference .", "sentence_id": 7}
+{"abstract_id": "25754845", "label": "conclusions", "text": "Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer .", "sentence_id": 8}
+{"abstract_id": "24477032", "label": "background", "text": "Applying appropriate positive end-expiratory pressure ( PEEP ) to corresponding intra-abdominal pressure ( IAP ) can improve gas exchange during capnoperitoneum without any hemodynamic effects .", "sentence_id": 0}
+{"abstract_id": "24477032", "label": "methods", "text": "A total of @ patients were randomly allocated to group @PEEP ( n = @ ) , group @PEEP ( n = @ ) , and group @PEEP ( n = @ ) according to the level of PEEP , in whom capnoperitoneum was created with IAP of @ , @ , and @ mm Hg , respectively .", "sentence_id": 1}
+{"abstract_id": "24477032", "label": "methods", "text": "Hemodynamic and respiratory parameters were recorded up to @ minutes after capnoperitoneum .", "sentence_id": 2}
+{"abstract_id": "24477032", "label": "results", "text": "In @PEEP group , mean end-tidal carbon dioxide demonstrated significant rise @ minutes after capnoperitoneum and plateaued at about @ minutes but remained at high level for up to @ minutes when compared with the @PEEP and @PEEP groups ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24477032", "label": "results", "text": "Correspondingly , the mean PaCO@ ( @ mm Hg ) for the @PEEP group was higher at @ minutes when compared with @PEEP ( @ mm Hg ) and @PEEP ( @ mm Hg ) groups .", "sentence_id": 4}
+{"abstract_id": "24477032", "label": "results", "text": "The oxygenation was better preserved in @PEEP and @PEEP groups with significantly higher PaO@/Fio@ ratio .", "sentence_id": 5}
+{"abstract_id": "24477032", "label": "results", "text": "Heart rate , mean arterial pressure , and cardiac output remained stable throughout the study in all the @ groups .", "sentence_id": 6}
+{"abstract_id": "24477032", "label": "conclusions", "text": "Application of appropriate PEEP corresponding to the IAP helped maintain CO@ elimination and improved oxygenation without any hemodynamic disturbance in patients undergoing laparoscopic cholecystectomy .", "sentence_id": 7}
+{"abstract_id": "24939433", "label": "objective", "text": "Isoflavones are present in soy foods and soy-based supplements .", "sentence_id": 0}
+{"abstract_id": "24939433", "label": "objective", "text": "Despite low plasma isoflavone concentrations in the general Western population , concentrations in supplement users exceed those suggested to be beneficial for health in Asian populations , raising concerns for adverse effects .", "sentence_id": 1}
+{"abstract_id": "24939433", "label": "objective", "text": "To aid risk assessment , quantification of the relation between isoflavone intake and plasma concentrations is essential .", "sentence_id": 2}
+{"abstract_id": "24939433", "label": "methods", "text": "Plasma samples were collected from postmenopausal women in three placebo-controlled crossover studies with @-week periods for supplements ( two studies , ~ @mg isoflavones/day , n = @ ) or @-week periods for soy foods ( one study , ~ @mg isoflavones/day , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24939433", "label": "methods", "text": "Plasma isoflavone concentrations ( daidzein , equol , genistein and glycitein ) were quantified using high-performance liquid chromatography and electrochemical detection .", "sentence_id": 4}
+{"abstract_id": "24939433", "label": "methods", "text": "The association between plasma concentrations and isoflavone intake , equol producer status , intake-producer interaction and background dietary intake was assessed based on the assumption of a log-linear relation .", "sentence_id": 5}
+{"abstract_id": "24939433", "label": "results", "text": "Median plasma total isoflavone concentrations after the soy food and supplement interventions were respectively @ and @ mol/l for equol producers and @ and @ mol/l for non-producers .", "sentence_id": 6}
+{"abstract_id": "24939433", "label": "results", "text": "Regression analysis showed that doubling isoflavone intake increased plasma concentrations by @-@ % ( s.e. @-@ % , R ( @ ) > @ ) for daidzein , genistein , equol ( only for producers ) and total isoflavones ; for glycitein the association was weaker ( @ % , R ( @ ) = @ ) .", "sentence_id": 7}
+{"abstract_id": "24939433", "label": "results", "text": "Adjustments for energy , carbohydrate and fat intake did not affect these estimates .", "sentence_id": 8}
+{"abstract_id": "24939433", "label": "results", "text": "Inter-individual variation , estimated based on repeated measures in one of the studies , was @-@ % .", "sentence_id": 9}
+{"abstract_id": "24939433", "label": "conclusions", "text": "Although the relation between isoflavone intake and plasma concentrations was adequately quantified , the use of isoflavone intake data for risk assessment needs caution due to large inter-individual variation in plasma concentrations .", "sentence_id": 10}
+{"abstract_id": "25907821", "label": "background", "text": "The simultaneous presence of cancer and other medical conditions ( comorbidity ) is frequent .", "sentence_id": 0}
+{"abstract_id": "25907821", "label": "background", "text": "Cigarette smoking is the major risk factor for as well head and neck cancer ( HNC ) and lung cancer ( LC ) as chronic obstructive pulmonary disease ( COPD ) .", "sentence_id": 1}
+{"abstract_id": "25907821", "label": "background", "text": "COPD is the most common comorbidity in LC patients , and presence of COPD worsens the prognosis of HNC and LC .", "sentence_id": 2}
+{"abstract_id": "25907821", "label": "background", "text": "COPD is under-diagnosed and under-treated in the Danish population .", "sentence_id": 3}
+{"abstract_id": "25907821", "label": "background", "text": "The aims of this study were to determine the prevalence of COPD in a HNC and LC population , and to determine the need and feasibility of a randomized controlled phase II trial comparing usual care with optimized medical treatment of COPD in cancer patients .", "sentence_id": 4}
+{"abstract_id": "25907821", "label": "methods", "text": "All patients with HNC or LC referred for oncologic treatment in a university hospital during a @-month period were invited to attend a pulmonary clinic for evaluation of lung function .", "sentence_id": 5}
+{"abstract_id": "25907821", "label": "methods", "text": "Patients who were found to have concomitant COPD were randomized to intervention or usual care .", "sentence_id": 6}
+{"abstract_id": "25907821", "label": "methods", "text": "Primary endpoints were prevalence of COPD among the referred patients with either LC or HNC , and further whether the patients that were diagnosed with COPD already received treatment in accordance with Danish COPD guidelines .", "sentence_id": 7}
+{"abstract_id": "25907821", "label": "methods", "text": "Secondary outcome was feasibility , i.e. the proportion of eligible patients that accepted follow-up in the pulmonary clinic for @ weeks in addition to oncological treatment .", "sentence_id": 8}
+{"abstract_id": "25907821", "label": "methods", "text": "The design of the randomized trail is described in detail .", "sentence_id": 9}
+{"abstract_id": "25907821", "label": "results", "text": "In total @ patients of whom @ % had LC and @ % HNC have been screened during the first seven months of this ongoing trial .", "sentence_id": 10}
+{"abstract_id": "25907821", "label": "results", "text": "Sixty-eight percent of LC patients and @ % of HNC patients had COPD .", "sentence_id": 11}
+{"abstract_id": "25907821", "label": "results", "text": "All but one of @ eligible patients accepted randomization .", "sentence_id": 12}
+{"abstract_id": "25907821", "label": "results", "text": "Nearly one third ( @ % ) of the LC and HNC patients with COPD were diagnosed prior to study entry , and of these , only @ % were receiving correct treatment according to current guidelines .", "sentence_id": 13}
+{"abstract_id": "25907821", "label": "conclusions", "text": "For patients with LC , and to a lesser extend HNC , there is a need for improved diagnosis and treatment of concomitant COPD .", "sentence_id": 14}
+{"abstract_id": "25907821", "label": "conclusions", "text": "Furthermore , patients found it acceptable to be scheduled for a @-week follow-up in a pulmonary clinic along with their oncological treatment .", "sentence_id": 15}
+{"abstract_id": "25101966", "label": "background", "text": "Existing eye-tracking literature has shown that both adults and children with autism spectrum disorders ( ASD ) show fewer and slower fixations on faces .", "sentence_id": 0}
+{"abstract_id": "25101966", "label": "background", "text": "Despite this reduced saliency and processing of other faces , recognition of their own face is reported to be more `` typical '' in nature .", "sentence_id": 1}
+{"abstract_id": "25101966", "label": "background", "text": "This study uses eye-tracking to explore the typicality of gaze patterns when children with ASD attend their own faces compared to other familiar and unfamiliar faces .", "sentence_id": 2}
+{"abstract_id": "25101966", "label": "methods", "text": "Eye-tracking methodology was used to explore fixation duration and time taken to fixate on the Eye and Mouth regions of familiar , unfamiliar and Self Faces .", "sentence_id": 3}
+{"abstract_id": "25101966", "label": "methods", "text": "Twenty-one children with ASD ( @-@ years ) were compared to typically developing matched groups .", "sentence_id": 4}
+{"abstract_id": "25101966", "label": "results", "text": "There were no significant differences between children with ASD and typically matched groups for fixation patterns to the Eye and Mouth areas of all face types ( familiar , unfamiliar and self ) .", "sentence_id": 5}
+{"abstract_id": "25101966", "label": "results", "text": "Correlational analyses showed that attention to the Eye area of unfamiliar and Self Faces was related to socio-communicative ability in children with ASD .", "sentence_id": 6}
+{"abstract_id": "25101966", "label": "conclusions", "text": "Levels of socio-communicative ability in children with ASD were related to gaze patterns on unfamiliar and Self Faces , but not familiar faces .", "sentence_id": 7}
+{"abstract_id": "25101966", "label": "conclusions", "text": "This lack of relationship between ability and attention to familiar faces may indicate that children across the autism spectrum are able to fixate these faces in a similar way .", "sentence_id": 8}
+{"abstract_id": "25101966", "label": "conclusions", "text": "The implications for these findings are discussed .", "sentence_id": 9}
+{"abstract_id": "25070547", "label": "objective", "text": "To determine if increasing the hormone dose or eliminating the hormone-free interval improves key pharmacokinetic ( PK ) alterations caused by obesity during oral contraceptive ( OC ) use .", "sentence_id": 0}
+{"abstract_id": "25070547", "label": "methods", "text": "Obese -LSB- body mass index ( BMI ) @ kg/m ( @ ) -RSB- , ovulatory , otherwise healthy , women received an OC containing @ mcg ethinyl estradiol ( EE ) / @ mcg levonorgestrel ( LNG ) dosed cyclically ( @ days active pills with @-day placebo week ) for two cycles and then were randomized for two additional cycles to the following : continuous cycling ( CC , a dose neutral arm using the same OC with no hormone-free interval ) or increased dose ( ID , a dose escalation arm using an OC containing @ mcg EE/@ mcg LNG cyclically ) .", "sentence_id": 1}
+{"abstract_id": "25070547", "label": "methods", "text": "During Cycles @ , @ and @ , outpatient visits were performed to assess maximum serum concentration ( Cmax ) , area under the curve ( AUC@ - ) and time to steady state as well as pharmacodynamics .", "sentence_id": 2}
+{"abstract_id": "25070547", "label": "methods", "text": "These key PK parameters were calculated and compared within groups between baseline and treatment cycles .", "sentence_id": 3}
+{"abstract_id": "25070547", "label": "results", "text": "A total of @ women enrolled and completed the study ( CC group , n = @ ; ID group , n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25070547", "label": "results", "text": "Demographics were similar between groups -LSB- mean BMI : CC , @ kg/m ( @ ) ( S.D. @ ) ; ID , @ kg/m ( @ ) ( S.D. @ ) -RSB- .", "sentence_id": 5}
+{"abstract_id": "25070547", "label": "results", "text": "At baseline , the key LNG PK parameters were no different between groups ; average time to reach steady state was @ days in both groups ; Cmax were CC : @ ng/mL and ID : @ ng/mL ; and AUC@ - were CC : @ h ng/mL and ID : @ h ng/mL .", "sentence_id": 6}
+{"abstract_id": "25070547", "label": "results", "text": "Following randomization , the CC group maintained steady-state serum levels whereas the ID group had a significantly higher Cmax ( p < @ ) but again required @ days to achieve steady state .", "sentence_id": 7}
+{"abstract_id": "25070547", "label": "results", "text": "However , AUC was not significantly different between CC ( @ h ng/mL ) and ID ( @ h ng/mL ) .", "sentence_id": 8}
+{"abstract_id": "25070547", "label": "results", "text": "Forty-five percent ( @/@ ) of the study population had evidence of an active follicle-like structure prior to randomization and afterwards this decreased to @ % ( @/@ ) .", "sentence_id": 9}
+{"abstract_id": "25070547", "label": "conclusions", "text": "Both increasing the OC dose and continuous dosing appear to counteract the impact of obesity on key OC PK parameters .", "sentence_id": 10}
+{"abstract_id": "25070547", "label": "conclusions", "text": "Obesity adversely affects the pharmacokinetics of very low dose OC pills .", "sentence_id": 11}
+{"abstract_id": "25070547", "label": "conclusions", "text": "Although the impact of these changes on OC efficacy is still under debate , PK parameters can be normalized in obese users by continuous dosing or increasing to a low-dose pill .", "sentence_id": 12}
+{"abstract_id": "25341431", "label": "background", "text": "Postural balance and potentially fall risk increases among older adults living with neurological diseases , especially Parkinson 's disease ( PD ) .", "sentence_id": 0}
+{"abstract_id": "25341431", "label": "background", "text": "Since conventional therapies such as levodopa or deep brain stimulation may fail to alleviate or may even worsen balance , interest is growing in evaluating alternative PD therapies .", "sentence_id": 1}
+{"abstract_id": "25341431", "label": "objective", "text": "The purpose of the current study was to assess improvement in postural balance in PD patients following electroacupuncture ( EA ) as an alternative therapy .", "sentence_id": 2}
+{"abstract_id": "25341431", "label": "methods", "text": "@ aging adults ( @ @ years ) with idiopathic PD and @ healthy age-matched participants ( @ @ years ) were recruited .", "sentence_id": 3}
+{"abstract_id": "25341431", "label": "methods", "text": "The PD participants were randomly assigned ( at a ratio of @:@ ) to an intervention ( n = @ ) or to a control group ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25341431", "label": "methods", "text": "The intervention group received a @-min EA treatment on a weekly basis for @ weeks , while the control group received a sham treatment .", "sentence_id": 5}
+{"abstract_id": "25341431", "label": "methods", "text": "Outcomes were assessed at baseline and after the final therapy .", "sentence_id": 6}
+{"abstract_id": "25341431", "label": "methods", "text": "Measurements included balance assessment , specifically the ratio of medial-lateral ( ML ) center-of-gravity ( COG ) sway to anterior-posterior ( AP ) sway ( COGML/AP ) and ankle/hip sway during eyes-open , eyes-closed , and eyes-open dual-task trials , the Unified Parkinson 's Disease Rating Scale ( UPDRS ) , as well as quality of life , concerns for fall , and pain questionnaires .", "sentence_id": 7}
+{"abstract_id": "25341431", "label": "results", "text": "No difference was observed for the assessed parameters between the intervention and the control group at baseline .", "sentence_id": 8}
+{"abstract_id": "25341431", "label": "results", "text": "After treatment , an improvement in balance performance was observed in the intervention group .", "sentence_id": 9}
+{"abstract_id": "25341431", "label": "results", "text": "Compared with the healthy population , PD patients prior to treatment had larger COGML/AP sway with more dependency on upper-body movements for maintaining balance .", "sentence_id": 10}
+{"abstract_id": "25341431", "label": "results", "text": "Following EA therapy , COGML/AP sway was reduced by @ % and ankle/hip sway increased by @ % in the different conditions ( p = @ for the dual-task condition ) .", "sentence_id": 11}
+{"abstract_id": "25341431", "label": "results", "text": "The clinical rating revealed an overall improvement ( p < @ ) in mentation , behavior , and mood ( UPDRS part I , @ % ) , activities of daily living ( UPDRS part II , @ % ) , and motor examination ( UPDRS part III , @ % ) .", "sentence_id": 12}
+{"abstract_id": "25341431", "label": "results", "text": "There was a significant reduction ( p < @ ) in the specific items regarding UPDRS fall status ( @ % ) and rigidity ( @ % ) .", "sentence_id": 13}
+{"abstract_id": "25341431", "label": "results", "text": "Changes were small and nonsignificant in the controls ( p > @ ) .", "sentence_id": 14}
+{"abstract_id": "25341431", "label": "conclusions", "text": "This pilot study demonstrates improvement in rigidity and balance following EA .", "sentence_id": 15}
+{"abstract_id": "25341431", "label": "conclusions", "text": "These preliminary results suggest EA could be a promising alternative treatment for balance disturbance in PD .", "sentence_id": 16}
+{"abstract_id": "25358095", "label": "background", "text": "Smoking reduction remains a pivotal issue in public health policy , but quit rates obtained with traditional quit-smoking therapies remain disappointingly low .", "sentence_id": 0}
+{"abstract_id": "25358095", "label": "background", "text": "Tobacco Harm Reduction ( THR ) , aiming at less harmful ways of consuming nicotine , may provide a more effective alternative .", "sentence_id": 1}
+{"abstract_id": "25358095", "label": "background", "text": "One promising candidate for THR are electronic cigarettes ( e-cigs ) .", "sentence_id": 2}
+{"abstract_id": "25358095", "label": "background", "text": "The aim of this study was to investigate the efficacy of second-generation e-cigs both in terms of acute craving-reduction in the lab and in terms of smoking reduction and experienced benefits/complaints in an eight-month Randomized Controlled Trial ( RCT ) .", "sentence_id": 3}
+{"abstract_id": "25358095", "label": "methods", "text": "RCT with three arms .", "sentence_id": 4}
+{"abstract_id": "25358095", "label": "methods", "text": "Participants ( N = @ ) unwilling to quit smoking were randomized into two e-cig groups and one control group .", "sentence_id": 5}
+{"abstract_id": "25358095", "label": "methods", "text": "During three lab sessions ( over two months ) participants , who had been abstinent for four hours , vaped/smoked for five minutes , after which we monitored the effect on craving and withdrawal symptoms .", "sentence_id": 6}
+{"abstract_id": "25358095", "label": "methods", "text": "eCO and saliva cotinine levels were also measured .", "sentence_id": 7}
+{"abstract_id": "25358095", "label": "methods", "text": "In between lab sessions , participants in the e-cig groups could use e-cigs or smoke ad libitum , whereas the control group could only smoke .", "sentence_id": 8}
+{"abstract_id": "25358095", "label": "methods", "text": "After the lab sessions , the control group also received an e-cig .", "sentence_id": 9}
+{"abstract_id": "25358095", "label": "methods", "text": "The RCT included several questionnaires , which repeatedly monitored the effect of ad libitum e-cig use on the use of tobacco cigarettes and the experienced benefits/complaints up to six months after the last lab session .", "sentence_id": 10}
+{"abstract_id": "25358095", "label": "results", "text": "From the first lab session on , e-cig use after four hours of abstinence resulted in a reduction in cigarette craving which was of the same magnitude as when a cigarette was smoked , while eCO was unaffected .", "sentence_id": 11}
+{"abstract_id": "25358095", "label": "results", "text": "After two months , we observed that @ % of the e-cig groups had stopped smoking tobacco cigarettes , versus @ % of the control group .", "sentence_id": 12}
+{"abstract_id": "25358095", "label": "results", "text": "After five months , the e-cig groups demonstrated a total quit-rate of @ % , whereas the control group showed a quit rate of @ % three months after initiating e-cig use .", "sentence_id": 13}
+{"abstract_id": "25358095", "label": "results", "text": "At the end of the eight-month study , @ % of the e-cig groups and @ % of the control group were totally abstinent from smoking , while an overall reduction of @ % in the number of cigarettes smoked per day was observed ( compared to intake ) .", "sentence_id": 14}
+{"abstract_id": "25358095", "label": "results", "text": "eCO levels decreased , whereas cotinine levels were the same in all groups at each moment of measurement .", "sentence_id": 15}
+{"abstract_id": "25358095", "label": "results", "text": "Reported benefits far outweighed the reported complaints .", "sentence_id": 16}
+{"abstract_id": "25358095", "label": "conclusions", "text": "In a series of controlled lab sessions with e-cig nave tobacco smokers , second generation e-cigs were shown to be immediately and highly effective in reducing abstinence induced cigarette craving and withdrawal symptoms , while not resulting in increases in eCO .", "sentence_id": 17}
+{"abstract_id": "25358095", "label": "conclusions", "text": "Remarkable ( > @ pc ) eight-month reductions in , or complete abstinence from tobacco smoking was achieved with the e-cig in almost half ( @ % ) of the participants .", "sentence_id": 18}
+{"abstract_id": "24783961", "label": "background", "text": "Improving nutrition and physical activity behaviors associated with childhood obesity are significant national public health goals .", "sentence_id": 0}
+{"abstract_id": "24783961", "label": "background", "text": "Energy Balance for Kids with Play ( EB@K with Play ) , developed through a partnership between the Academy of Nutrition and Dietetics Foundation and Playworks , is a multi-component school-based intervention designed to address youth 's nutrition and physical activity behaviors .", "sentence_id": 1}
+{"abstract_id": "24783961", "label": "background", "text": "This article describes the EB@K with Play intervention and evaluation study and presents the baseline data .", "sentence_id": 2}
+{"abstract_id": "24783961", "label": "methods", "text": "The evaluation is a @-year cluster-randomized design targeting third - to fifth-grade students enrolled in a low-income , urban school district in northern California .", "sentence_id": 3}
+{"abstract_id": "24783961", "label": "methods", "text": "Six schools were recruited to participate .", "sentence_id": 4}
+{"abstract_id": "24783961", "label": "methods", "text": "Four were randomized to the intervention group and two into a control group .", "sentence_id": 5}
+{"abstract_id": "24783961", "label": "methods", "text": "Baseline student-level data pertaining to nutrition , physical activity , fitness , and BMI were collected in the fall of @ .", "sentence_id": 6}
+{"abstract_id": "24783961", "label": "methods", "text": "The EB@K with Play program , which includes direct-to-student nutrition and physical activity interventions , a school wellness component , and parent/community partner outreach components , began immediately after baseline data collection .", "sentence_id": 7}
+{"abstract_id": "24783961", "label": "results", "text": "An ethnically diverse sample of students ( n = @ ) was recruited to participate in the study .", "sentence_id": 8}
+{"abstract_id": "24783961", "label": "results", "text": "Baseline data showed a higher percent of eligibility for free and reduced-price school lunch and higher rates of obesity/overweight than the California state averages .", "sentence_id": 9}
+{"abstract_id": "24783961", "label": "results", "text": "Fitness levels and levels of moderate-to-vigorous physical activity were comparable to state averages .", "sentence_id": 10}
+{"abstract_id": "24783961", "label": "conclusions", "text": "End-point data will be collected after @ years of the intervention .", "sentence_id": 11}
+{"abstract_id": "24783961", "label": "conclusions", "text": "The findings from this study should help guide future efforts to design effective intervention programs to support the prevention of pediatric obesity .", "sentence_id": 12}
+{"abstract_id": "25040180", "label": "background", "text": "A topical fixed-dose clindamycin phosphate @ % and benzoyl peroxide @ % combination gel ( CLNP/BPO @ % ) is known to be effective and safe in white people with acne .", "sentence_id": 0}
+{"abstract_id": "25040180", "label": "objective", "text": "To evaluate the efficacy and safety of CLNP/BPO @ % topically applied once or twice daily vs. CLNP twice daily in Japanese patients with acne .", "sentence_id": 1}
+{"abstract_id": "25040180", "label": "methods", "text": "Eight hundred patients were randomized to receive CLNP/BPO @ % once daily , CLNP/BPO @ % twice daily or CLNP twice daily for @weeks .", "sentence_id": 2}
+{"abstract_id": "25040180", "label": "methods", "text": "Primary endpoints were absolute change in number of total lesions ( TLs ) from baseline to week @ to demonstrate the superiority of CLNP/BPO @ % twice daily and noninferiority of CLNP/BPO @ % once daily vs. CLNP twice daily .", "sentence_id": 3}
+{"abstract_id": "25040180", "label": "methods", "text": "Secondary endpoints were absolute and percentage changes in TLs , inflammatory lesions ( ILs ) , noninflammatory lesions ( non-ILs ) and Investigator 's Static Global Assessment ( ISGA ) score .", "sentence_id": 4}
+{"abstract_id": "25040180", "label": "methods", "text": "Safety assessments included adverse events ( AEs ) , laboratory tests , vital signs and local skin tolerability .", "sentence_id": 5}
+{"abstract_id": "25040180", "label": "results", "text": "Change in TL counts from baseline to week @ for CLNP/BPO @ % twice daily was superior to CLNP twice daily ( difference -@ ; P < @ ) ; CLNP/BPO @ % once daily was not inferior to CLNP twice daily ( difference -@ ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25040180", "label": "results", "text": "Absolute and percentage reductions in TL , IL and non-IL counts and ISGA score were greater for CLNP/BPO @ % once or twice daily than for CLNP twice daily with significant differences seen from early on .", "sentence_id": 7}
+{"abstract_id": "25040180", "label": "results", "text": "Most AEs were mild or moderate .", "sentence_id": 8}
+{"abstract_id": "25040180", "label": "results", "text": "The incidence of adverse drug reactions was higher for CLNP/BPO @ % once ( @ % ) or twice ( @ % ) daily than for CLNP twice daily ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "25040180", "label": "conclusions", "text": "Compared with CLNP twice daily , CLNP/BPO @ % once daily was more effective and CLNP/BPO @ % twice daily at least as effective , with an early onset of action and an acceptable safety and tolerability profile in Japanese patients .", "sentence_id": 10}
+{"abstract_id": "25265449", "label": "objective", "text": "No effective pharmaceutical agents have yet been identified to treat acute kidney injury after cardiac surgery .", "sentence_id": 0}
+{"abstract_id": "25265449", "label": "objective", "text": "To determine whether fenoldopam reduces the need for renal replacement therapy in critically ill cardiac surgery patients with acute kidney injury .", "sentence_id": 1}
+{"abstract_id": "25265449", "label": "methods", "text": "Multicenter , randomized , double-blind , placebo-controlled , parallel-group study from March @ to April @ in @ cardiovascular intensive care units in Italy .", "sentence_id": 2}
+{"abstract_id": "25265449", "label": "methods", "text": "We randomly assigned @ patients admitted to intensive care units after cardiac surgery with early acute kidney injury ( @ % increase of serum creatinine level from baseline or oliguria for @ hours ) to receive fenoldopam ( @ patients ) or placebo ( @ patients ) .", "sentence_id": 3}
+{"abstract_id": "25265449", "label": "methods", "text": "We used a computer-generated permuted block randomization sequence for treatment allocation .", "sentence_id": 4}
+{"abstract_id": "25265449", "label": "methods", "text": "All patients completed their follow-up @ days after surgery , and data were analyzed according to the intention-to-treat principle .", "sentence_id": 5}
+{"abstract_id": "25265449", "label": "methods", "text": "Continuous infusion of fenoldopam or placebo for up to @ days with a starting dose of @ g/kg/min ( range , @-@ @ g/kg/min ) .", "sentence_id": 6}
+{"abstract_id": "25265449", "label": "methods", "text": "The primary end point was the rate of renal replacement therapy .", "sentence_id": 7}
+{"abstract_id": "25265449", "label": "methods", "text": "Secondary end points included mortality ( intensive care unit and @-day mortality ) and the rate of hypotension during study drug infusion .", "sentence_id": 8}
+{"abstract_id": "25265449", "label": "results", "text": "The study was stopped for futility as recommended by the safety committee after a planned interim analysis .", "sentence_id": 9}
+{"abstract_id": "25265449", "label": "results", "text": "Sixty-nine of @ patients ( @ % ) allocated to the fenoldopam group and @ of @ patients ( @ % ) allocated to the placebo group received renal replacement therapy ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25265449", "label": "results", "text": "Mortality at @ days was @ of @ ( @ % ) in the fenoldopam group and @ of @ ( @ % ) in the placebo group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25265449", "label": "results", "text": "Hypotension occurred in @ ( @ % ) patients in the fenoldopam group and in @ ( @ % ) patients in the placebo group ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25265449", "label": "conclusions", "text": "Among patients with acute kidney injury after cardiac surgery , fenoldopam infusion , compared with placebo , did not reduce the need for renal replacement therapy or risk of @-day mortality but was associated with an increased rate of hypotension .", "sentence_id": 13}
+{"abstract_id": "24886638", "label": "background", "text": "Osteoarthritis ( OA ) is a common problem in older women that is associated with pain and disabilities .", "sentence_id": 0}
+{"abstract_id": "24886638", "label": "background", "text": "Although yoga is recommended as an exercise intervention to manage arthritis , there is limited evidence documenting its effectiveness , with little known about its long term benefits .", "sentence_id": 1}
+{"abstract_id": "24886638", "label": "background", "text": "This study 's aims were to assess the feasibility and potential efficacy of a Hatha yoga exercise program in managing OA-related symptoms in older women with knee OA .", "sentence_id": 2}
+{"abstract_id": "24886638", "label": "methods", "text": "Eligible participants ( N = @ ; mean age @ years ) were randomly assigned to @-week yoga program involving group and home-based sessions or wait-list control .", "sentence_id": 3}
+{"abstract_id": "24886638", "label": "methods", "text": "The yoga intervention program was developed by a group of yoga experts ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "24886638", "label": "methods", "text": "The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index ( WOMAC ) total score that measures knee OA pain , stiffness , and function at @ weeks .", "sentence_id": 5}
+{"abstract_id": "24886638", "label": "methods", "text": "The secondary outcomes , physical function of the lower extremities , body mass index ( BMI ) , quality of sleep ( QOS ) , and quality of life ( QOL ) , were measured using weight , height , the short physical performance battery ( SPPB ) , the Pittsburgh Sleep Quality Index ( PSQI ) , the Cantril Self-Anchoring Ladder , and the SF@v@ Health Survey .", "sentence_id": 6}
+{"abstract_id": "24886638", "label": "methods", "text": "Data were collected at baseline , @ weeks and @ weeks , and @ weeks .", "sentence_id": 7}
+{"abstract_id": "24886638", "label": "results", "text": "The recruitment target was met , with study retention at @ % .", "sentence_id": 8}
+{"abstract_id": "24886638", "label": "results", "text": "Based on ANCOVAs , participants in the treatment group exhibited significantly greater improvement in WOMAC pain ( adjusted means -LSB- SE -RSB- ) ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) , stiffness ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) and SPPB ( repeated chair stands ) ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) at @ weeks .", "sentence_id": 9}
+{"abstract_id": "24886638", "label": "results", "text": "Significant treatment and time effects were seen in WOMAC pain ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) , function ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) and total scores ( @ -LSB- @ -RSB- , @ -LSB- @ -RSB- ; p = @ ) from @ to @ weeks .", "sentence_id": 10}
+{"abstract_id": "24886638", "label": "results", "text": "Sleep disturbance was improved but the PSQI total score declined significantly at @ weeks .", "sentence_id": 11}
+{"abstract_id": "24886638", "label": "results", "text": "Changes in BMI and QOL were not significant .", "sentence_id": 12}
+{"abstract_id": "24886638", "label": "results", "text": "No yoga related adverse events were observed .", "sentence_id": 13}
+{"abstract_id": "24886638", "label": "conclusions", "text": "A weekly yoga program with home practice is feasible , acceptable , and safe for older women with knee OA , and shows therapeutic benefits .", "sentence_id": 14}
+{"abstract_id": "24384959", "label": "objective", "text": "To select suitable chemotherapy for cervical cancer patients by ATP-tumor chemosensitivity assay .", "sentence_id": 0}
+{"abstract_id": "24384959", "label": "methods", "text": "Seventy-two hospitalized patients with cervical cancer between July @ and October @ were enrolled .", "sentence_id": 1}
+{"abstract_id": "24384959", "label": "methods", "text": "The patients were randomly divided into a trial group ( n = @ ) and a control group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24384959", "label": "methods", "text": "ATP-TCA was used to detect the sensitivity of @ samples of cervical cancer in the trial group to @ combined chemotherapy regimens .", "sentence_id": 3}
+{"abstract_id": "24384959", "label": "methods", "text": "The chemotherapy regimen in the trial group was confirmed by the results of susceptibility testing and that in the control group was confirmed by clinical experience .", "sentence_id": 4}
+{"abstract_id": "24384959", "label": "methods", "text": "One-year recurrence rate and @ - year survival rate of two groups were compared after @ year follow-up .", "sentence_id": 5}
+{"abstract_id": "24384959", "label": "results", "text": "ATP-TCA was measured in @ of the @ patients in the trial group .", "sentence_id": 6}
+{"abstract_id": "24384959", "label": "results", "text": "The sensitive patients for paclitaxel + carboplatin , paclitaxel + oxaliplatin , bleomycin + ifosfamide + cisplatin , bleomycin + vincristine + cisplatin , fluorouracil + cisplatin , and gemcitabine + cisplatin were @ , @ , @ , @ , @ , and @ , respectively .", "sentence_id": 7}
+{"abstract_id": "24384959", "label": "results", "text": "There was no significant difference in the @-year recurrence between the two groups ( P > @ ) , while the @-year survivors in the trial group were more than those in the control group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24384959", "label": "conclusions", "text": "ATP-TCA method is good for patients with cervical cancer because it is sensitive , effective , and individualized .", "sentence_id": 9}
+{"abstract_id": "25439084", "label": "background", "text": "Exercise is a potential treatment for depression .", "sentence_id": 0}
+{"abstract_id": "25439084", "label": "background", "text": "However , few studies have evaluated the role of adjunct exercise in the treatment of severely major depressed inpatients .", "sentence_id": 1}
+{"abstract_id": "25439084", "label": "background", "text": "The goal of this study was to evaluate the effects of add-on exercise on the usual treatment of severely depressed inpatients .", "sentence_id": 2}
+{"abstract_id": "25439084", "label": "methods", "text": "Fifty participants were randomized to an exercise ( exercise + usual treatment ) or a control ( usual treatment ) group .", "sentence_id": 3}
+{"abstract_id": "25439084", "label": "methods", "text": "Twenty-five patients were randomly allocated to each group .", "sentence_id": 4}
+{"abstract_id": "25439084", "label": "methods", "text": "The participants in the exercise group performed three sessions per week throughout the hospitalization period , with a goal dose of @ kcal/kg/week plus the usual pharmacological treatment .", "sentence_id": 5}
+{"abstract_id": "25439084", "label": "methods", "text": "Depressive symptoms and the Quality of Life ( QoL ) of the participants were assessed at the baseline , the second week , and discharge .", "sentence_id": 6}
+{"abstract_id": "25439084", "label": "results", "text": "A significant group time interaction was found for depressive symptoms and the physical and psychological domains of QoL .", "sentence_id": 7}
+{"abstract_id": "25439084", "label": "results", "text": "Differences between groups occurred at the second week and discharge with respect to depressive symptoms and the physical and psychological domains of QoL .", "sentence_id": 8}
+{"abstract_id": "25439084", "label": "results", "text": "There was no difference in the remission rate at discharge ( @ % and @ % for the exercise and control group , respectively ) .", "sentence_id": 9}
+{"abstract_id": "25439084", "label": "results", "text": "An NNT of @ was found .", "sentence_id": 10}
+{"abstract_id": "25439084", "label": "results", "text": "No significant baseline characteristics predict remission at discharge .", "sentence_id": 11}
+{"abstract_id": "25439084", "label": "conclusions", "text": "Add-on exercise is an efficacious treatment for severely depressed inpatients , improving their depressive symptoms and QoL .", "sentence_id": 12}
+{"abstract_id": "25439084", "label": "conclusions", "text": "Initial acceptance of exercise remains a challenge .", "sentence_id": 13}
+{"abstract_id": "25692840", "label": "background", "text": "The IMProved Reduction of Outcomes : Vytorin Efficacy International Trial ( IMPROVE-IT ) is evaluating the potential benefit for reduction in major cardiovascular ( CV ) events from the addition of ezetimibe versus placebo to @ mg/d of simvastatin therapy in patients who present with acute coronary syndromes and have low-density lipoprotein cholesterol ( LDL-C ) @ mg/dl .", "sentence_id": 0}
+{"abstract_id": "25692840", "label": "methods", "text": "Randomized double blind clinical trial in patients with acute coronary syndrome and low cholesterol level .", "sentence_id": 1}
+{"abstract_id": "25692840", "label": "methods", "text": "The simvastatin monotherapy arms LDL-C target was < @ mg/dl , the comparison arm was simvastatin + ezetimibe .", "sentence_id": 2}
+{"abstract_id": "25692840", "label": "methods", "text": "Ezetimibe was assumed to further lower LDL-C by @ mg/dl and produce an estimated ~ @ % to @ % treatment effect .", "sentence_id": 3}
+{"abstract_id": "25692840", "label": "methods", "text": "The primary composite end point was CV death , nonfatal myocardial infarction ( MI ) , nonfatal stroke , rehospitalization for unstable angina ( UA ) , and coronary revascularization ( @ days postrandomization ) .", "sentence_id": 4}
+{"abstract_id": "25692840", "label": "methods", "text": "The targeted number of events was @,@ .", "sentence_id": 5}
+{"abstract_id": "25692840", "label": "results", "text": "@,@ patients were enroled with either ST segment elevation MI ( STEMI , n = @,@ ) or UA/non-ST segment elevation MI ( UA/NSTEMI , n = @,@ ) from October @ to July @ .", "sentence_id": 6}
+{"abstract_id": "25692840", "label": "results", "text": "Primary endpoint occured in @ patients ( @ % ) treated with simvastatin in monotherapy and in @ patients ( @ % ) ( p = @ ) treated with combination .", "sentence_id": 7}
+{"abstract_id": "25692840", "label": "results", "text": "Compared to patients with coronary heart disease given the drug simvastatin plus a placebo , those given both simvastatin and the non-statin drug , ezetimibe , had a @ % lower combined risk of subsequent heart attack , stroke , cardiovascular death , rehospitalization for unstable angina and procedures to restore blood flow to the heart .", "sentence_id": 8}
+{"abstract_id": "25692840", "label": "results", "text": "Heart attacks alone were reduced by @ % , and non-fatal stroke by @ % .", "sentence_id": 9}
+{"abstract_id": "25692840", "label": "results", "text": "Deaths from cardiovascular disease were statistically the same in both groups .", "sentence_id": 10}
+{"abstract_id": "25692840", "label": "results", "text": "Patients were followed an average of approximately six years , and some as long as @ years .", "sentence_id": 11}
+{"abstract_id": "25692840", "label": "results", "text": "Approximately @ patients out of every @ patients treated for @ years avoided a heart attack or stroke -LSB- Number Needed to Treat ( NNT ) = @/@ years -RSB- .", "sentence_id": 12}
+{"abstract_id": "25692840", "label": "conclusions", "text": "The study has shown a claer benefit from combination treatment with simvastatin and ezetimibe in patients with acute coronary syndrome and low LDL-C .", "sentence_id": 13}
+{"abstract_id": "24705855", "label": "objective", "text": "We investigated the feasibility and acceptance of electronic monitoring of symptoms and syndromes in oncological outpatient clinics using a PALM ( handheld computer ) .", "sentence_id": 0}
+{"abstract_id": "24705855", "label": "methods", "text": "The assessment of a combination of symptoms and clinical benefit parameters grouped in four pairs was tested in a pilot phase in advanced cancer patients .", "sentence_id": 1}
+{"abstract_id": "24705855", "label": "methods", "text": "Based on these experiences , the software E-MOSAIC was developed , consisting of patient-reported symptoms and nutritional intake and objective assessments ( weight , weight loss , performance status and medication for pain , fatigue , and cachexia ) .", "sentence_id": 2}
+{"abstract_id": "24705855", "label": "methods", "text": "E-MOSAIC was then tested in four Swiss oncology centers .", "sentence_id": 3}
+{"abstract_id": "24705855", "label": "methods", "text": "In order to compare the methods , patients completed the E-MOSAIC as a paper and a PALM version .", "sentence_id": 4}
+{"abstract_id": "24705855", "label": "methods", "text": "Preferences of version and completion times were collected .", "sentence_id": 5}
+{"abstract_id": "24705855", "label": "methods", "text": "Assessments were compared using Wilcoxon signed-rank tests , and the test-retest reliability was evaluated .", "sentence_id": 6}
+{"abstract_id": "24705855", "label": "results", "text": "The pilot phase was completed by @ patients .", "sentence_id": 7}
+{"abstract_id": "24705855", "label": "results", "text": "Most patients and physicians perceived the assessment as useful .", "sentence_id": 8}
+{"abstract_id": "24705855", "label": "results", "text": "Sixty-two patients participated in the feasibility study .", "sentence_id": 9}
+{"abstract_id": "24705855", "label": "results", "text": "Twelve patients reported problems ( understanding , optical , tactile ) , and five patients could not complete the assessment .", "sentence_id": 10}
+{"abstract_id": "24705855", "label": "results", "text": "The median time to complete the PALM-based assessment was @min .", "sentence_id": 11}
+{"abstract_id": "24705855", "label": "results", "text": "Forty-nine percent of patients preferred the PALM , @ % preferred a paper version , and @ % of patients had no preference .", "sentence_id": 12}
+{"abstract_id": "24705855", "label": "results", "text": "Paper vs. PALM revealed no significant differences in symptoms , but in nutritional intake ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24705855", "label": "results", "text": "Test-retest ( @h , n = @ ) reliability was satisfactory ( r = @-@ ) .", "sentence_id": 14}
+{"abstract_id": "24705855", "label": "conclusions", "text": "Electronic symptom and clinical benefit monitoring is feasible in oncology outpatient clinics and perceived as useful by patients , oncology nurses , and oncologists .", "sentence_id": 15}
+{"abstract_id": "24705855", "label": "conclusions", "text": "E-MOSAIC is tested in a prospective randomized trial .", "sentence_id": 16}
+{"abstract_id": "24669146", "label": "objective", "text": "To perform a comparative evaluation of the efficacy and acceptability of Rose-K and Soper contact lenses in Keratoconus .", "sentence_id": 0}
+{"abstract_id": "24669146", "label": "methods", "text": "Dr. Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi .", "sentence_id": 1}
+{"abstract_id": "24669146", "label": "methods", "text": "A randomized comparative clinical trial was performed in keratoconic eyes fitted with Rose-K ( Rose-K group ) and Soper ( Soper group ) contact lenses .", "sentence_id": 2}
+{"abstract_id": "24669146", "label": "methods", "text": "Patients data were evaluated for best spectacle corrected visual acuity , best contact lens corrected visual acuity ( BCLCVA ) , corneal topography , glare acuity , contrast sensitivity , tear function tests and specular microscopy .", "sentence_id": 3}
+{"abstract_id": "24669146", "label": "methods", "text": "Patients were also asked to complete a self-reported comfort questionnaire at each visit .", "sentence_id": 4}
+{"abstract_id": "24669146", "label": "results", "text": "Sixty eyes were randomized to the Rose-K and Soper groups .", "sentence_id": 5}
+{"abstract_id": "24669146", "label": "results", "text": "The two groups were comparable in all the baseline parameters .", "sentence_id": 6}
+{"abstract_id": "24669146", "label": "results", "text": "There was a statistically significant improvement in BCLCVA in both groups at @ months ( P < @ , both groups ) .", "sentence_id": 7}
+{"abstract_id": "24669146", "label": "results", "text": "The difference between in BCLCVA in both groups was not statistically significant .", "sentence_id": 8}
+{"abstract_id": "24669146", "label": "results", "text": "In both groups , there was a significant improvement in the comfort score at @ months compared to baseline ( P < @ , both group ) .", "sentence_id": 9}
+{"abstract_id": "24669146", "label": "results", "text": "The Rose-K group had statistically significantly better scores at @ and @ months compared with the Soper group ( P = @ and P < @ respectively ) .", "sentence_id": 10}
+{"abstract_id": "24669146", "label": "results", "text": "Both groups were associated with a significant ( P < @ ) , but comparable improvement in glare acuity at @ months .", "sentence_id": 11}
+{"abstract_id": "24669146", "label": "results", "text": "There was a significant improvement in contrast sensitivity at @ months in both groups ( P < @ ) ; the Rose-K group was significantly better than the Soper group at @ and @ months ( P = @ and @ respectively ) .", "sentence_id": 12}
+{"abstract_id": "24669146", "label": "results", "text": "The mean number of trial lenses required for fitting Rose-K lens ( @ @ ) was significantly lower than the Soper lens ( @ @ ; P < @ ) .", "sentence_id": 13}
+{"abstract_id": "24669146", "label": "conclusions", "text": "Both the contact lens designs provide an equal improvement in visual acuity in patients with Keratoconus .", "sentence_id": 14}
+{"abstract_id": "24669146", "label": "conclusions", "text": "However , Rose-K contact lens provides greater comfort , better quality of vision and requires less chair time compared with the Soper lens and hence may possibly have a greater acceptability .", "sentence_id": 15}
+{"abstract_id": "25854021", "label": "objective", "text": "To observe the effect of electroacupuncture ( EA ) combined with ultraviolet therapy on herpes zoster at the acute stage and the impacts on serum interleukin @ ( IL-@ ) , interleukin @ ( IL-@ ) and interleukin @ ( IL-@ ) in the patients .", "sentence_id": 0}
+{"abstract_id": "25854021", "label": "methods", "text": "Thirty-four patients of herpes zoster were randomized into a medicine group and a combined therapy group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25854021", "label": "methods", "text": "In the medicine group , the intravenous drops with acyclovir injection , muscular injection with cobamamide and the topical with acyclovir ointment were applied .", "sentence_id": 2}
+{"abstract_id": "25854021", "label": "methods", "text": "Additionally , TDP was radiated locally .", "sentence_id": 3}
+{"abstract_id": "25854021", "label": "methods", "text": "In the combined therapy group , on the basis of the treatment as the medicine group , EA and ultraviolet therapy were supplemented .", "sentence_id": 4}
+{"abstract_id": "25854021", "label": "methods", "text": "The duration of treatment was @ days in the two groups .", "sentence_id": 5}
+{"abstract_id": "25854021", "label": "methods", "text": "Before and after treatment , blister relief , incrustation time and the visible analogue scale ( VAS ) were recorded in the two groups .", "sentence_id": 6}
+{"abstract_id": "25854021", "label": "methods", "text": "The clinical efficacy was assessed in the two groups and the levels of serum IL-@ , IL-@ and IL-@ were determined in the two groups .", "sentence_id": 7}
+{"abstract_id": "25854021", "label": "results", "text": "In the combined therapy group , the time of blister relief and incrustation was earlier apparently than that in the medicine group ( both P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25854021", "label": "results", "text": "VAS score after treatment were reduced as compared with that before treatment in the two groups ( both P < @ ) , and the reducing amplitude in the combined therapy group was larger than that in the medicine group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25854021", "label": "results", "text": "The total effective rate was @ % ( @/@ ) in the combined therapy group , higher than @ % ( @/@ ) in the medicine group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25854021", "label": "results", "text": "After treatment , IL-@ levels were increased as compared with those before treatment in the two groups ( both P < @ ) , the levels of IL-@ and IL-@ were reduced obviously as compared with those before treatment in the two groups ( all P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25854021", "label": "results", "text": "After treatment , the levels of IL-@ , IL-@ were reduced much more apparently in the combined therapy group as compared with those in the medicine group ( both P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25854021", "label": "conclusions", "text": "EA combined with ultraviolet irradiation more rapidly and effectively relief the symptoms of herpes zoster , significantly relief pain , shorten the duration of sickness , improve the body immunity and reduce nerve injury .", "sentence_id": 13}
+{"abstract_id": "25881751", "label": "background", "text": "Imatinib mesylate ( IM ) is a selective tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors .", "sentence_id": 0}
+{"abstract_id": "25881751", "label": "background", "text": "A new once-daily @-mg film-coated tablet of imatinib has been developed by a pharmaceutical company in Korea .", "sentence_id": 1}
+{"abstract_id": "25881751", "label": "objective", "text": "The present study was designed to assess and compare the PK parameters , bioavailability , and bioequivalence of the new imatinib @-mg formulation ( test ) versus the conventional @-mg formulation ( reference ) administered as a single @-mg dose in healthy adult male volunteers .", "sentence_id": 2}
+{"abstract_id": "25881751", "label": "methods", "text": "This randomized , open-label , single-dose , two-way crossover study was conducted in healthy Korean male volunteers .", "sentence_id": 3}
+{"abstract_id": "25881751", "label": "methods", "text": "Eligible subjects were randomly assigned in a @ : @ ratio to receive @ mg of the test ( one @-mg tablet ) or reference ( four @-mg tablets ) formulation , followed by a @-week washout period and administration of the alternate formulation .", "sentence_id": 4}
+{"abstract_id": "25881751", "label": "methods", "text": "Serial blood samples were collected at @ ( predose ) , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , and @ hours after administration .", "sentence_id": 5}
+{"abstract_id": "25881751", "label": "methods", "text": "Plasma imatinib concentrations were determined using liquid chromatography coupled with tandem mass spectrometry .", "sentence_id": 6}
+{"abstract_id": "25881751", "label": "methods", "text": "The formulations were to be considered bioequivalent if the @ % confidence intervals ( CIs ) of the adjusted geometric mean ratios for Cmax , AUC ( @-t ) , and AUC ( @ - ) were within the predetermined range of @ - @ .", "sentence_id": 7}
+{"abstract_id": "25881751", "label": "results", "text": "In total , @ subjects completed the study .", "sentence_id": 8}
+{"abstract_id": "25881751", "label": "results", "text": "No serious adverse event was reported during the study .", "sentence_id": 9}
+{"abstract_id": "25881751", "label": "results", "text": "The @ % CIs of the adjusted geometric mean ratios of the test formulation to the reference formulation for C ( max ) , AUC ( @-t ) and AUC ( @ - ) of imatinib were all within the bioequivalence criteria range of @ - @ .", "sentence_id": 10}
+{"abstract_id": "25881751", "label": "conclusions", "text": "The test formulation of imatinib met the Korean regulatory requirements for bioequivalence .", "sentence_id": 11}
+{"abstract_id": "25881751", "label": "conclusions", "text": "Both imatinib formulations were well-tolerated in all subjects .", "sentence_id": 12}
+{"abstract_id": "25972254", "label": "objective", "text": "To assess the safety and effectiveness of the Hydrus Microstent ( Ivantis , Inc , Irvine , CA ) with concurrent cataract surgery ( CS ) for reducing intraocular pressure ( IOP ) in open-angle glaucoma ( OAG ) .", "sentence_id": 0}
+{"abstract_id": "25972254", "label": "methods", "text": "Prospective , multicenter , randomized , single-masked , controlled clinical trial .", "sentence_id": 1}
+{"abstract_id": "25972254", "label": "methods", "text": "One hundred eyes from @ patients @ to @ years of age with OAG and cataract with IOP of @ mmHg or less with @ or fewer hypotensive medications and a washed-out diurnal IOP ( DIOP ) of @ to @ mmHg .", "sentence_id": 2}
+{"abstract_id": "25972254", "label": "methods", "text": "On the day of surgery , patients were randomized @:@ to undergo CS with the microstent or CS alone .", "sentence_id": 3}
+{"abstract_id": "25972254", "label": "methods", "text": "Postoperative follow-up was at @ day , @ week , and @ , @ , @ , @ , @ , and @ months .", "sentence_id": 4}
+{"abstract_id": "25972254", "label": "methods", "text": "Washout of hypotensive medications was repeated at @ and @ months .", "sentence_id": 5}
+{"abstract_id": "25972254", "label": "methods", "text": "Response to treatment was defined as a @ % or more decrease in washed out DIOP at @ and @ months of follow-up compared with baseline .", "sentence_id": 6}
+{"abstract_id": "25972254", "label": "methods", "text": "Mean DIOP at @ and @ months , the proportion of subjects requiring medications at follow-up , and the mean number of medications were analyzed .", "sentence_id": 7}
+{"abstract_id": "25972254", "label": "methods", "text": "Safety measures included change in visual acuity , slit-lamp observations , and adverse events .", "sentence_id": 8}
+{"abstract_id": "25972254", "label": "results", "text": "The proportion of patients with a @ % reduction in washed out DIOP was significantly higher in the Hydrus plus CS group at @ months compared with the CS group ( @ % vs. @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25972254", "label": "results", "text": "Washed out mean DIOP in the Hydrus plus CS group was significantly lower at @ months compared with the CS group ( @ mmHg vs. @ mmHg ; P = @ ) , and the proportion of patients using no hypotensive medications was significantly higher at @ months in the Hydrus plus CS group ( @ % vs. @ % ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25972254", "label": "results", "text": "There were no differences in follow-up visual acuity between groups .", "sentence_id": 11}
+{"abstract_id": "25972254", "label": "results", "text": "The only notable device-related adverse event was focal peripheral anterior synechiae ( @-@ mm in length ) .", "sentence_id": 12}
+{"abstract_id": "25972254", "label": "results", "text": "Otherwise , adverse event frequency was similar in the @ groups .", "sentence_id": 13}
+{"abstract_id": "25972254", "label": "conclusions", "text": "Intraocular pressure was clinically and statistically significantly lower at @ years in the Hydrus plus CS group compared with the CS alone group , with no differences in safety .", "sentence_id": 14}
+{"abstract_id": "24996984", "label": "objective", "text": "To determine whether bronchoalveolar lavage ( BAL ) - directed therapy for infants and young children with cystic fibrosis ( CF ) , rather than standard therapy , was justified on the grounds of a decrease in average costs and whether the use of BAL reduced treatment costs associated with hospital admissions .", "sentence_id": 0}
+{"abstract_id": "24996984", "label": "methods", "text": "Costs were assessed in a randomized controlled trial conducted in Australia and New Zealand on infants diagnosed with CF after newborn screening and assigned to receive either BAL-directed or standard therapy until they reached @ years of age .", "sentence_id": 1}
+{"abstract_id": "24996984", "label": "methods", "text": "A health care funder perspective was adopted .", "sentence_id": 2}
+{"abstract_id": "24996984", "label": "methods", "text": "Resource use measurement was based on standardized data collection forms administered for patients across all sites .", "sentence_id": 3}
+{"abstract_id": "24996984", "label": "methods", "text": "Unit costs were obtained primarily from government schedules .", "sentence_id": 4}
+{"abstract_id": "24996984", "label": "results", "text": "Mean costs per child during the study period were Australian dollars ( AUD ) @ in BAL-directed therapy group and AUD@ in standard therapy group ( mean difference AUD@ , @ % CI AUD-@ to @ , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24996984", "label": "results", "text": "Mean hospital costs per child during the study period were AUD@ in the BAL-directed therapy group and AUD@ in the standard therapy group ( mean difference AUD-@ ; @ % CI AUD-@ to @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24996984", "label": "conclusions", "text": "BAL-directed therapy did not result in either lower mean hospital admission costs or mean costs overall compared with managing patients with CF by a standard protocol based upon clinical features and oropharyngeal culture results alone .", "sentence_id": 7}
+{"abstract_id": "24996984", "label": "conclusions", "text": "Following on our previous findings that BAL-directed treatment offers no clinical advantage over standard therapy at age @ years , flexible bronchoscopy with BAL can not be recommended for the routine management of preschool children with CF on the basis of overall cost savings .", "sentence_id": 8}
+{"abstract_id": "25493129", "label": "background", "text": "Recent research has investigated the use of ultrasound ( US ) for confirming endotracheal tube ( ETT ) placement with varying techniques , accuracies , and challenges .", "sentence_id": 0}
+{"abstract_id": "25493129", "label": "background", "text": "Our objective was to evaluate the accuracy of a novel , simplified , four-step ( @S ) technique .", "sentence_id": 1}
+{"abstract_id": "25493129", "label": "methods", "text": "We conducted a blinded , randomized trial of the @S technique utilizing an adult human cadaver model .", "sentence_id": 2}
+{"abstract_id": "25493129", "label": "methods", "text": "ETT placement was randomized to tracheal or esophageal location .", "sentence_id": 3}
+{"abstract_id": "25493129", "label": "methods", "text": "Three US experts and @ emergency medicine residents ( EMR ) performed a total of @ scans .", "sentence_id": 4}
+{"abstract_id": "25493129", "label": "methods", "text": "The primary outcome was the overall sensitivity and specificity of both experts and EMRs to detect location of ETT placement .", "sentence_id": 5}
+{"abstract_id": "25493129", "label": "methods", "text": "Secondary outcomes included a priori subgroup comparison of experts and EMRs for thin and obese cadavers , time to detection , and level of operator confidence .", "sentence_id": 6}
+{"abstract_id": "25493129", "label": "results", "text": "Experts had a sensitivity of @ % ( @ % CI = @ % to @ % ) and specificity of @ % ( @ % CI = @ % to @ % ) on thin , and a sensitivity of @ % ( @ % CI = @ % to @ % ) and specificity of @ % ( @ % CI = @ % to @ % ) on obese cadavers .", "sentence_id": 7}
+{"abstract_id": "25493129", "label": "results", "text": "EMRs had a sensitivity of @ % ( @ % CI = @ % to @ % ) and of specificity @ % ( @ % CI = @ % to @ % ) on thin , and a sensitivity of @ % ( @ % CI = @ % to @ % ) specificity of @ % ( @ % CI = @ % to @ % ) on obese cadavers .", "sentence_id": 8}
+{"abstract_id": "25493129", "label": "results", "text": "The overall mean time to detection was @ seconds ( @ % CI = @ seconds to @ seconds , range : @ to @ seconds ) for US experts and @ seconds ( @ % CI = @ seconds to @ seconds ; range : @ to @ seconds ) for EMRs .", "sentence_id": 9}
+{"abstract_id": "25493129", "label": "results", "text": "There was a statistically significant decrease in the specificity of this technique on obese cadavers when comparing the EMRs and experts , as well as an increased overall time to detection among the EMRs .", "sentence_id": 10}
+{"abstract_id": "25493129", "label": "conclusions", "text": "The simplified @S technique was accurate and rapid for US experts .", "sentence_id": 11}
+{"abstract_id": "25493129", "label": "conclusions", "text": "Among novices , the @S technique was accurate in thin , but appears less accurate in obese cadavers .", "sentence_id": 12}
+{"abstract_id": "25493129", "label": "conclusions", "text": "Further studies will determine optimal teaching time and accuracy in emergency department patients .", "sentence_id": 13}
+{"abstract_id": "25771069", "label": "objective", "text": "Uncertainty remains about the efficacy of folic acid therapy for the primary prevention of stroke because of limited and inconsistent data .", "sentence_id": 0}
+{"abstract_id": "25771069", "label": "objective", "text": "To test the primary hypothesis that therapy with enalapril and folic acid is more effective in reducing first stroke than enalapril alone among Chinese adults with hypertension .", "sentence_id": 1}
+{"abstract_id": "25771069", "label": "methods", "text": "The China Stroke Primary Prevention Trial , a randomized , double-blind clinical trial conducted from May @ , @ , to August @ , @ , in @ communities in Jiangsu and Anhui provinces in China .", "sentence_id": 2}
+{"abstract_id": "25771069", "label": "methods", "text": "A total of @,@ adults with hypertension without history of stroke or myocardial infarction ( MI ) participated in the study .", "sentence_id": 3}
+{"abstract_id": "25771069", "label": "methods", "text": "Eligible participants , stratified by MTHFR C@T genotypes ( CC , CT , and TT ) , were randomly assigned to receive double-blind daily treatment with a single-pill combination containing enalapril , @ mg , and folic acid , @ mg ( n = @,@ ) or a tablet containing enalapril , @ mg , alone ( n = @,@ ) .", "sentence_id": 4}
+{"abstract_id": "25771069", "label": "methods", "text": "The primary outcome was first stroke .", "sentence_id": 5}
+{"abstract_id": "25771069", "label": "methods", "text": "Secondary outcomes included first ischemic stroke ; first hemorrhagic stroke ; MI ; a composite of cardiovascular events consisting of cardiovascular death , MI , and stroke ; and all-cause death .", "sentence_id": 6}
+{"abstract_id": "25771069", "label": "results", "text": "During a median treatment duration of @ years , compared with the enalapril alone group , the enalapril-folic acid group had a significant risk reduction in first stroke ( @ % of participants in the enalapril-folic acid group vs @ % in the enalapril alone group ; hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @-@ @ ) , first ischemic stroke ( @ % with enalapril-folic acid vs @ % with enalapril alone ; HR , @ ; @ % CI , @-@ @ ) , and composite cardiovascular events consisting of cardiovascular death , MI , and stroke ( @ % with enalapril-folic acid vs @ % with enalapril alone ; HR , @ ; @ % CI , @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "25771069", "label": "results", "text": "The risks of hemorrhagic stroke ( HR , @ ; @ % CI , @-@ @ ) , MI ( HR , @ ; @ % CI , @-@ @ ) , and all-cause deaths ( HR , @ ; @ % CI , @-@ @ ) did not differ significantly between the @ treatment groups .", "sentence_id": 8}
+{"abstract_id": "25771069", "label": "results", "text": "There were no significant differences between the @ treatment groups in the frequencies of adverse events .", "sentence_id": 9}
+{"abstract_id": "25771069", "label": "conclusions", "text": "Among adults with hypertension in China without a history of stroke or MI , the combined use of enalapril and folic acid , compared with enalapril alone , significantly reduced the risk of first stroke .", "sentence_id": 10}
+{"abstract_id": "25771069", "label": "conclusions", "text": "These findings are consistent with benefits from folate use among adults with hypertension and low baseline folate levels .", "sentence_id": 11}
+{"abstract_id": "24819432", "label": "objective", "text": "To establish whether there was a difference in health-related quality of life ( HRQoL ) in people with chronic musculoskeletal disorders ( PwCMSKD ) after participating in a multimodal physiotherapy program ( MPP ) either two or three sessions a week .", "sentence_id": 0}
+{"abstract_id": "24819432", "label": "methods", "text": "Total of @ PwCMSKD participated in this prospective randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "24819432", "label": "methods", "text": "An individualised MPP , consisting of exercises for mobility , motor-control , muscle strengthening , cardiovascular training , and health education , was implemented either twice a week ( G@ : n = @ ) or three times a week ) ( G@ : n = @ ) for @ year .", "sentence_id": 2}
+{"abstract_id": "24819432", "label": "results", "text": "HRQoL physical and mental health state ( PHS/MHS ) , Roland Morris disability Questionnaire ( RMQ ) , Neck-Disability-Index ( NDI ) and Western Ontario and McMaster Universities ' Arthritis Index ( WOMAC ) were used to measure outcomes of MPP for people with chronic low back pain , chronic neck pain and osteoarthritis , respectively .", "sentence_id": 3}
+{"abstract_id": "24819432", "label": "results", "text": "Measures were taken at baseline , @ weeks ( @ w ) , @ months ( @m ) , and @ year ( @y ) after starting the programme .", "sentence_id": 4}
+{"abstract_id": "24819432", "label": "results", "text": "No statistically significant differences were found between the two groups ( G@ and G@ ) , except in NDI at @ w ( -@ , ( CI @ % : -@ / @ , p = @ ( scale @-@ ) ) .", "sentence_id": 5}
+{"abstract_id": "24819432", "label": "results", "text": "All variables showed improvement reaching the following values ( from baseline to @y ) G@ : PHS : @ ( baseline : @ ; ( improvement : @ % ) , MHS : @ ( baseline : @ , @ % ) , HRQoL @ ( baseline : @ , @ % ) ) , HRQoL-VAS @ ( baseline : @ , @ % ) , RMQ @ ( baseline : @ , @ % ) , NDI @ ( baseline : @ , @ % ) , WOMAC @ ( baseline : @ , @ % ) .", "sentence_id": 6}
+{"abstract_id": "24819432", "label": "results", "text": "G@ : PHS : @ ( baseline : @ , @ % ) , MHS : @ ( baseline : @ , ( @ % ) , HRQoL @ ( baseline : @ , @ % ) , HRQoL-VAS @ ( baseline : @ , @ % ) , RMQ @ ( baseline : @ , @ % ) , NDI @ ( baseline : @ , @ % ) , WOMAC @ ( baseline : @ , @ % ) .", "sentence_id": 7}
+{"abstract_id": "24819432", "label": "conclusions", "text": "No significant differences between the two groups were found in the outcomes of a MPP except in the NDI at @ weeks , but both groups improved in all variables during the course of @ year under study .", "sentence_id": 8}
+{"abstract_id": "24819432", "label": "conclusions", "text": "Implications for Rehabilitation A multimodal physiotherapy program ( MPP ) improves quality of life , overall health , and function in people with chronic musculoskeletal disease after an intervention of short , medium and long term .", "sentence_id": 9}
+{"abstract_id": "24819432", "label": "conclusions", "text": "This implies that twice a week MPP for people with chronic musculoskeletal pain has comparable results to three times a week provision and therefore may have implications in saving resources and cost for patients and service providers without compromising the outcomes of treatment .", "sentence_id": 10}
+{"abstract_id": "24819432", "label": "conclusions", "text": "These results can be considered not only for therapists , but also for managers who offer the services to optimise the balance cost-effectiveness of the proposed interventions .", "sentence_id": 11}
+{"abstract_id": "24232362", "label": "objective", "text": "The beneficial role of exercise as a treatment approach in Huntington 's disease ( HD ) has support from both preclinical work and small-scale studies ; however , there have been no controlled studies of gym-based exercise in people with HD .", "sentence_id": 0}
+{"abstract_id": "24232362", "label": "objective", "text": "This phase @ randomized trial ( ISRCTN @ ) assessed feasibility , safety , acceptability , and benefit of a structured exercise program .", "sentence_id": 1}
+{"abstract_id": "24232362", "label": "methods", "text": "Thirty-one participants ( @ men ; mean -LSB- SD -RSB- age = @ -LSB- @ -RSB- years ) were randomly allocated to intervention ( n = @ ) or control group ( usual care ; n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24232362", "label": "methods", "text": "The intervention entailed a weekly supervised gym session of stationary cycling and resistance exercises , and a twice weekly independent home-based walking program .", "sentence_id": 3}
+{"abstract_id": "24232362", "label": "methods", "text": "Retention and adherence rates and adverse events were recorded .", "sentence_id": 4}
+{"abstract_id": "24232362", "label": "methods", "text": "Acceptability was determined from subjective reports of tolerability and physiological measures recorded during the gym sessions .", "sentence_id": 5}
+{"abstract_id": "24232362", "label": "methods", "text": "Assessment of benefit included measures of physical abilities , disease severity , and quality of life ( @-Item Short Form Health Survey ) .", "sentence_id": 6}
+{"abstract_id": "24232362", "label": "methods", "text": "Analysis of covariance was used to test outcomes of interest .", "sentence_id": 7}
+{"abstract_id": "24232362", "label": "results", "text": "The retention rate was @ % ( @ of the @ individuals who started the intervention completed it ) and of the @ who completed the program , @ attended more than @ % ( @/@ ) of the gym sessions .", "sentence_id": 8}
+{"abstract_id": "24232362", "label": "results", "text": "There were no related adverse events and the intervention was well tolerated by most participants .", "sentence_id": 9}
+{"abstract_id": "24232362", "label": "results", "text": "The between-group effect estimate for the Mental Component Summary score of the @-Item Short Form Health Survey ( n = @ ; intervention , n = @ ; control ) was @ ( @ % CI : @-@ @ ) Moderate effect sizes for cognitive outcomes and measures of walking were also observed .", "sentence_id": 10}
+{"abstract_id": "24232362", "label": "conclusions", "text": "Observed effect sizes for clinical outcomes suggest the structured exercise program has benefit for persons with HD ; larger scale trials are warranted.Video Abstract available ( see Video , Supplemental Digital Content @ , http://links.lww.com/JNPT/A@ ) for more insights from the authors .", "sentence_id": 11}
+{"abstract_id": "25116938", "label": "background", "text": "To optimize positive outcomes , the design of new pharmacy services should consider the preferences of consumers with chronic condition ( s ) and their carers .", "sentence_id": 0}
+{"abstract_id": "25116938", "label": "objective", "text": "( i ) To evaluate the relative importance of community pharmacy service characteristics , from the perspective of consumers with chronic condition ( s ) and carers ; ( ii ) To compare consumer and carer preferences to health professional beliefs about ideal service characteristics for consumers .", "sentence_id": 1}
+{"abstract_id": "25116938", "label": "methods", "text": "A discrete choice experiment was completed by consumers with chronic condition ( s ) and/or carers ( n = @ ) and health professionals ( n = @ ) , recruited from four regions in Australia .", "sentence_id": 2}
+{"abstract_id": "25116938", "label": "methods", "text": "Participants were each randomized to one survey version containing four ( from a total @ ) different choices between two new pharmacy services .", "sentence_id": 3}
+{"abstract_id": "25116938", "label": "methods", "text": "Consumer and carer participants were also given an ` opt out ' alternative of current service .", "sentence_id": 4}
+{"abstract_id": "25116938", "label": "methods", "text": "Each service was described using six attributes related to pharmacy service characteristics : continued medicines supply , continuity and coordinated care , location , medication management , education and information , and cost .", "sentence_id": 5}
+{"abstract_id": "25116938", "label": "results", "text": "Consumers and carers placed highest priority on continued medicines supply by a pharmacist for regular and symptom flare up medicines ( @ priority points ) , a pharmacy located within a ` one-stop ' health center ( @ points ) and home delivery of medicines ( @ points ) .", "sentence_id": 6}
+{"abstract_id": "25116938", "label": "results", "text": "Although continuedmedicines supply was most important for consumers and carers , pharmacy location was perceivedby health professionals to be the most important characteristic for consumers .", "sentence_id": 7}
+{"abstract_id": "25116938", "label": "results", "text": "Participants were less inclined to choose new services if their current pharmacy offered high quality services thatwere person-centered , easy to access and responsive to their needs .", "sentence_id": 8}
+{"abstract_id": "25116938", "label": "results", "text": "Younger , more highly educated and employed participants , and those with established condition ( s ) were more likely to choose new services .", "sentence_id": 9}
+{"abstract_id": "25116938", "label": "conclusions", "text": "Person-centered care is a fundamental tenet for pharmacy services .", "sentence_id": 10}
+{"abstract_id": "25116938", "label": "conclusions", "text": "The provision of continued medicines supply ( e.g. through pharmacist prescribing ) , convenient and coordinated care delivered through a one stop health centre , and home delivery of medicines , should be prioritized when planning pharmacy services to best assist consumers to manage chronic conditions .", "sentence_id": 11}
+{"abstract_id": "24360924", "label": "objective", "text": "Farm youth continue to experience high rates of injury and deaths as a result of agricultural activities .", "sentence_id": 0}
+{"abstract_id": "24360924", "label": "objective", "text": "Farm machinery , especially tractors , is the most common cause of casualties to youth .", "sentence_id": 1}
+{"abstract_id": "24360924", "label": "objective", "text": "A Roll-Over Protection Structure ( ROPS ) along with a fastened seatbelt can prevent almost all injuries and fatalities from tractor overturns .", "sentence_id": 2}
+{"abstract_id": "24360924", "label": "objective", "text": "Despite this knowledge , the use of seatbelts by farmers on ROPS tractors remains low .", "sentence_id": 3}
+{"abstract_id": "24360924", "label": "objective", "text": "This study treats farm safety as a family issue and builds on the central role of parents as teachers and role models of farm safety for youth .", "sentence_id": 4}
+{"abstract_id": "24360924", "label": "methods", "text": "This research study used a longitudinal , repeated-measures , randomized-control design in which youth @-@years of age were randomly assigned to either of two intervention groups ( parent-led group and staff-led group ) or the control group .", "sentence_id": 5}
+{"abstract_id": "24360924", "label": "results", "text": "Fathers in the parent-led group were less likely to operate ROPS tractors without a seatbelt compared with other groups .", "sentence_id": 6}
+{"abstract_id": "24360924", "label": "results", "text": "They were more likely to have communicated with youth about the importance of wearing seatbelts on ROPS tractors .", "sentence_id": 7}
+{"abstract_id": "24360924", "label": "results", "text": "Consequently , youth in the parent-led group were less likely to operate a ROPS tractor without a seatbelt than the control group at post-test .", "sentence_id": 8}
+{"abstract_id": "24360924", "label": "conclusions", "text": "This randomized control trial supports the effectiveness of a home-based , father-led farm safety intervention as a promising strategy for reducing youth as well as father-unsafe behaviors ( related to tractor seatbelts ) on the farm .", "sentence_id": 9}
+{"abstract_id": "24360924", "label": "conclusions", "text": "This intervention appealed to fathers ' strong motivation to practice tractor safety for the sake of their youth .", "sentence_id": 10}
+{"abstract_id": "24360924", "label": "conclusions", "text": "Involving fathers helped change both father as well as youth unsafe tractor-seatbelt behaviors .", "sentence_id": 11}
+{"abstract_id": "24255597", "label": "background", "text": "Several studies have confirmed dramatic changes in skin surface parameters during the winter months .", "sentence_id": 0}
+{"abstract_id": "24255597", "label": "background", "text": "Although there are many studies supporting the positive effects of topical treatment , there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter .", "sentence_id": 1}
+{"abstract_id": "24255597", "label": "background", "text": "The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments .", "sentence_id": 2}
+{"abstract_id": "24255597", "label": "methods", "text": "This study included @ healthy female volunteers aged @-@ years with phototype II-IV skin .", "sentence_id": 3}
+{"abstract_id": "24255597", "label": "methods", "text": "Randomization was balanced .", "sentence_id": 4}
+{"abstract_id": "24255597", "label": "methods", "text": "Two tablets of a micronutrient supplement ( Perfectil Platinum ) or placebo were administered once daily for @ months .", "sentence_id": 5}
+{"abstract_id": "24255597", "label": "methods", "text": "The volunteers were examined at baseline , after @ months , and @ weeks after termination of treatment ( month @ ) .", "sentence_id": 6}
+{"abstract_id": "24255597", "label": "methods", "text": "The evaluation included skin microrelief by Visioscan as the main outcome , and the secondary outcomes were results on standard macrophotography , skin tension by Reviscometer , skin high-frequency ultrasound , and self-assessment .", "sentence_id": 7}
+{"abstract_id": "24255597", "label": "results", "text": "For all pseudoroughness and microrelief indicators , there was a significant increase from baseline to month @ in the placebo group ( P < @ ) but no change in the active group .", "sentence_id": 8}
+{"abstract_id": "24255597", "label": "results", "text": "Descriptive statistics for the mean minimum , mean maximum , and minimum to maximum ratio on the nonexposed study zone showed a significant and dramatic difference between baseline and month @ and between baseline and month @ ( P < @ ) in the active group , indicating decreasing anisotropy of the skin .", "sentence_id": 9}
+{"abstract_id": "24255597", "label": "results", "text": "High-frequency ultrasound on the exposed study zone revealed that skin thickness was significantly decreased in the placebo group during winter but was stable in the treated group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24255597", "label": "results", "text": "The photography scaling and self-assessment questionnaire revealed no significant changes in either group .", "sentence_id": 11}
+{"abstract_id": "24255597", "label": "conclusions", "text": "These results indicate that the skin is prone to seasonal changes during winter , particularly in exposed areas .", "sentence_id": 12}
+{"abstract_id": "24255597", "label": "conclusions", "text": "The data also indicate that oral supplementation can be a safe treatment , with no serious side effects , and may prevent or even eliminate the negative effects of winter on the skin .", "sentence_id": 13}
+{"abstract_id": "25576320", "label": "objective", "text": "To compare the effectiveness of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle with that of intrauterine insemination with controlled ovarian hyperstimulation in terms of a healthy child .", "sentence_id": 0}
+{"abstract_id": "25576320", "label": "methods", "text": "Multicentre , open label , three arm , parallel group , randomised controlled non-inferiority trial .", "sentence_id": 1}
+{"abstract_id": "25576320", "label": "methods", "text": "@ centres in the Netherlands .", "sentence_id": 2}
+{"abstract_id": "25576320", "label": "methods", "text": "Couples seeking fertility treatment after at least @ months of unprotected intercourse , with the female partner aged between @ and @ years , an unfavourable prognosis for natural conception , and a diagnosis of unexplained or mild male subfertility .", "sentence_id": 3}
+{"abstract_id": "25576320", "label": "methods", "text": "Three cycles of in vitro fertilisation with single embryo transfer ( plus subsequent cryocycles ) , six cycles of in vitro fertilisation in a modified natural cycle , or six cycles of intrauterine insemination with ovarian hyperstimulation within @ months after randomisation .", "sentence_id": 4}
+{"abstract_id": "25576320", "label": "methods", "text": "The primary outcome was birth of a healthy child resulting from a singleton pregnancy conceived within @ months after randomisation .", "sentence_id": 5}
+{"abstract_id": "25576320", "label": "methods", "text": "Secondary outcomes were live birth , clinical pregnancy , ongoing pregnancy , multiple pregnancy , time to pregnancy , complications of pregnancy , and neonatal morbidity and mortality", "sentence_id": 6}
+{"abstract_id": "25576320", "label": "results", "text": "@ couples were randomly assigned between January @ and February @ ; @ were allocated to in vitro fertilisation with single embryo transfer , @ to in vitro fertilisation in a modified natural cycle , and @ to intrauterine insemination with controlled ovarian hyperstimulation .", "sentence_id": 7}
+{"abstract_id": "25576320", "label": "results", "text": "Birth of a healthy child occurred in @ ( @ % ) couples in the in vitro fertilisation with single embryo transfer group , @ ( @ % ) in the in vitro fertilisation in a modified natural cycle group , and @ ( @ % ) in the intrauterine insemination with controlled ovarian hyperstimulation group .", "sentence_id": 8}
+{"abstract_id": "25576320", "label": "results", "text": "This corresponds to a risk , relative to intrauterine insemination with ovarian hyperstimulation , of @ ( @ % confidence interval @ to @ ) for in vitro fertilisation with single embryo transfer and @ ( @ to @ ) for in vitro fertilisation in a modified natural cycle .", "sentence_id": 9}
+{"abstract_id": "25576320", "label": "results", "text": "These @ % confidence intervals do not extend below the predefined threshold of @ for inferiority .", "sentence_id": 10}
+{"abstract_id": "25576320", "label": "results", "text": "Multiple pregnancy rates per ongoing pregnancy were @ % ( @/@ ) after in vitro fertilisation with single embryo transfer , @ % ( @/@ ) after in vitro fertilisation in a modified natural cycle , and @ % ( @/@ ) after intrauterine insemination with ovarian hyperstimulation ( one sided P = @ for in vitro fertilisation with single embryo transfer compared with intrauterine insemination with ovarian hyperstimulation ; one sided P = @ for in vitro fertilisation in a modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation ) .", "sentence_id": 11}
+{"abstract_id": "25576320", "label": "conclusions", "text": "In vitro fertilisation with single embryo transfer and in vitro fertilisation in a modified natural cycle were non-inferior to intrauterine insemination with controlled ovarian hyperstimulation in terms of the birth of a healthy child and showed comparable , low multiple pregnancy rates.Trial registration Current Controlled Trials ISRCTN@ ; Nederlands Trial Register NTR@ .", "sentence_id": 12}
+{"abstract_id": "25415157", "label": "objective", "text": "The comparative risks and benefits of early compared with delayed cord clamping in the preterm neonate remain unclear .", "sentence_id": 0}
+{"abstract_id": "25415157", "label": "objective", "text": "Our objective was to evaluate the short-term effects of delayed clamping of the umbilical cord in preterm neonates .", "sentence_id": 1}
+{"abstract_id": "25415157", "label": "methods", "text": "We conducted a randomized controlled trial comparing immediate with delayed cord clamping among preterm neonates born between @ and @ weeks of gestation .", "sentence_id": 2}
+{"abstract_id": "25415157", "label": "methods", "text": "The primary study outcome was the need for blood transfusion .", "sentence_id": 3}
+{"abstract_id": "25415157", "label": "methods", "text": "To detect a @ % reduction in this outcome ( from @ to @ % ) with a two-tailed of @ and of @ required @ patients equally divided into two groups .", "sentence_id": 4}
+{"abstract_id": "25415157", "label": "results", "text": "A total of @ women were randomized , @ to the delayed and @ to the immediate clamp group .", "sentence_id": 5}
+{"abstract_id": "25415157", "label": "results", "text": "The groups were similar with respect to baseline characteristics .", "sentence_id": 6}
+{"abstract_id": "25415157", "label": "results", "text": "The mean gestational age at delivery was @ weeks in the delayed compared with @ weeks in the immediate clamp group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25415157", "label": "results", "text": "There was no statistically significant difference between groups with regard to the need for blood transfusion : @ of @ ( @ % ) in the delayed cord clamp group received one or more blood transfusion compared with @ of @ ( @ % ) in the immediate clamp group ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25415157", "label": "results", "text": "The rates of various neonatal outcomes including respiratory distress syndrome , periventricular leukomalacia , necrotizing enterocolitis , anemia of prematurity , and neonatal morality did not differ significantly between the groups .", "sentence_id": 9}
+{"abstract_id": "25415157", "label": "results", "text": "However , the mean initial hemoglobin ( @ compared with @ g/dL , P = @ ) and hematocrit ( @ compared with @ , P = @ ) was significantly higher in the delayed group .", "sentence_id": 10}
+{"abstract_id": "25415157", "label": "results", "text": "In the delayed clamp group , @ % ( @/@ ) of neonates had intraventricular hemorrhage compared with @ % ( @/@ ) in the immediate clamp group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25415157", "label": "conclusions", "text": "Delayed cord clamping for @ seconds did not decrease the need for blood transfusion among preterm neonates .", "sentence_id": 12}
+{"abstract_id": "25037201", "label": "background", "text": "Acute hamstring re-injuries are common and hard to predict .", "sentence_id": 0}
+{"abstract_id": "25037201", "label": "background", "text": "The aim of this study was to investigate the association between clinical and imaging findings and the occurrence of hamstring re-injuries .", "sentence_id": 1}
+{"abstract_id": "25037201", "label": "methods", "text": "We obtained baseline data ( clinical and MRI findings ) of athletes who sustained an acute hamstring injury within @days of initial injury .", "sentence_id": 2}
+{"abstract_id": "25037201", "label": "methods", "text": "We also collected data of standardised clinical tests within @days after return to play ( RTP ) .", "sentence_id": 3}
+{"abstract_id": "25037201", "label": "methods", "text": "The number of re-injuries was recorded within @months .", "sentence_id": 4}
+{"abstract_id": "25037201", "label": "methods", "text": "We analysed the association between the possible predictive variables and re-injuries with a multivariate Cox proportional-hazards regression model .", "sentence_id": 5}
+{"abstract_id": "25037201", "label": "results", "text": "Eighty patients were included at baseline and @ patients could be included in the final analysis because data after RTP were not available in @ cases .", "sentence_id": 6}
+{"abstract_id": "25037201", "label": "results", "text": "There were @ re-injuries ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25037201", "label": "results", "text": "None of the baseline MRI findings were univariately associated with re-injury .", "sentence_id": 8}
+{"abstract_id": "25037201", "label": "results", "text": "A higher number of previous hamstring injuries ( adjusted OR ( AOR ) @ ; @ % CI @ to @ ) , more degrees of active knee extension deficit after RTP ( AOR @ ; @ % CI @ to @ ) , isometric knee flexion force deficit at @ after RTP ( AOR @ ; @ % CI @ to @ ) and presence of localised discomfort on hamstring palpation after RTP ( AOR @ ; @ % CI @ to @ ) were significant independent predictors of re-injury .", "sentence_id": 9}
+{"abstract_id": "25037201", "label": "results", "text": "Athletes with localised discomfort on hamstring palpation just after RTP were consequently almost four times more likely to sustain a re-injury .", "sentence_id": 10}
+{"abstract_id": "25037201", "label": "conclusions", "text": "The number of previous hamstring injuries , active knee extension deficit , isometric knee flexion force deficit at @ and presence of localised discomfort on palpation just after RTP are associated with a higher hamstring re-injury rate .", "sentence_id": 11}
+{"abstract_id": "25037201", "label": "conclusions", "text": "None of the baseline MRI parameters was a predictor of hamstring re-injury .", "sentence_id": 12}
+{"abstract_id": "25851766", "label": "objective", "text": "Intra-arterial treatment ( IAT ) in patients with acute ischemic stroke ( AIS ) can be performed with or without general anesthesia ( GA ) .", "sentence_id": 0}
+{"abstract_id": "25851766", "label": "objective", "text": "Previous studies suggested that IAT without the use of GA ( non-GA ) is associated with better clinical outcome .", "sentence_id": 1}
+{"abstract_id": "25851766", "label": "objective", "text": "Nevertheless , no consensus exists about the anesthetic management during IAT of AIS patients .", "sentence_id": 2}
+{"abstract_id": "25851766", "label": "objective", "text": "This study investigates the association between type of anesthesia and clinical outcome in a large cohort of patients with AIS treated with IAT .", "sentence_id": 3}
+{"abstract_id": "25851766", "label": "methods", "text": "All consecutive patients with AIS of the anterior circulation who received IAT between @ and @ in @ Dutch hospitals were included in the study .", "sentence_id": 4}
+{"abstract_id": "25851766", "label": "methods", "text": "Primary outcome was functional outcome on the modified Rankin Scale at discharge .", "sentence_id": 5}
+{"abstract_id": "25851766", "label": "methods", "text": "Difference in primary outcome between GA and non-GA was estimated using multiple ordinal regression analysis , adjusting for age , stroke severity , occlusion of the internal carotid artery terminus , previous stroke , atrial fibrillation , and diabetes mellitus .", "sentence_id": 6}
+{"abstract_id": "25851766", "label": "results", "text": "Three hundred forty-eight patients were included in the analysis ; @ patients received GA and @ patients did not receive GA. .", "sentence_id": 7}
+{"abstract_id": "25851766", "label": "results", "text": "Non-GA was significantly associated with good clinical outcome ( odds ratio @ , @ % confidence interval @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25851766", "label": "results", "text": "After adjusting for prespecified prognostic factors , the point estimate remained similar ; statistical significance , however , was lost ( odds ratio @ , @ % confidence interval @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25851766", "label": "conclusions", "text": "Our study suggests that patients with AIS of the anterior circulation undergoing IAT without GA have a higher probability of good clinical outcome compared with patients treated with general anesthesia .", "sentence_id": 10}
+{"abstract_id": "24613691", "label": "objective", "text": "Restenosis is a limitation of endovascular interventions performed in the superficial femoral artery ( SFA ) .", "sentence_id": 0}
+{"abstract_id": "24613691", "label": "objective", "text": "Preclinical studies have demonstrated that the perivascular delivery of tissue-engineered allogeneic aortic endothelial cells ( PVS-@ ) reduced stenosis in porcine models of SFA revascularization .", "sentence_id": 1}
+{"abstract_id": "24613691", "label": "objective", "text": "The purpose of this study was to investigate the safety and feasibility of percutaneous PVS-@ delivery after angioplasty and stenting in the SFA of patients with peripheral artery disease .", "sentence_id": 2}
+{"abstract_id": "24613691", "label": "methods", "text": "In this phase I open-label trial , @ patients ( average lesion length of @ @ cm and @ % stenosis ) were treated with PVS-@ : @ in a low-dose cohort ( cohort A ) and @ in a high-dose cohort ( cohort B ) .", "sentence_id": 3}
+{"abstract_id": "24613691", "label": "methods", "text": "The primary objective was to demonstrate the safety ( incidence of major adverse events ) of PVS-@ within @ weeks after surgery .", "sentence_id": 4}
+{"abstract_id": "24613691", "label": "methods", "text": "Secondary end points included assessments of resting ankle-brachial index ( ABI ) in the treated leg , Fontaine class , and time to target lesion revascularization ( TLR ) .", "sentence_id": 5}
+{"abstract_id": "24613691", "label": "results", "text": "No patient had a major adverse event within @ weeks .", "sentence_id": 6}
+{"abstract_id": "24613691", "label": "results", "text": "One patient required a limb amputation at @ weeks .", "sentence_id": 7}
+{"abstract_id": "24613691", "label": "results", "text": "At @ weeks , cohort A and cohort B patients maintained a @ % and @ % increase in ABI compared with baseline , respectively ; @ % of cohort A and @ % of cohort B improved by @ Fontaine classification stage , and the TLR rate was @ % for cohort A and @ % for cohort B.", "sentence_id": 8}
+{"abstract_id": "24613691", "label": "conclusions", "text": "Percutaneous local delivery of PVS-@ is a well-tolerated and novel therapeutic approach that may be a suitable treatment for patients after endovascular intervention of the SFA .", "sentence_id": 9}
+{"abstract_id": "24613691", "label": "conclusions", "text": "Larger randomized trials are needed to determine if PVS-@ can improve ABI and reduce TLR rates .", "sentence_id": 10}
+{"abstract_id": "26027613", "label": "background", "text": "Prior studies have demonstrated a significant gap between guideline-based recommendations and clinical practice in the management of acute ischemic stroke ( AIS ) in China .", "sentence_id": 0}
+{"abstract_id": "26027613", "label": "objective", "text": "This study implements a targeted multifaceted quality improvement intervention in AIS patients and identifies the feasibility and efficacy of this intervention .", "sentence_id": 1}
+{"abstract_id": "26027613", "label": "methods", "text": "This is a multicenter , @-arm , open-label , cluster-randomized trial involving @ clusters ( hospitals ) from China National Network of Stroke Research .", "sentence_id": 2}
+{"abstract_id": "26027613", "label": "methods", "text": "Hospitals are randomized to receive a targeted multifaceted quality improvement intervention ( experimental group ) or routine standard of care ( control group ) .", "sentence_id": 3}
+{"abstract_id": "26027613", "label": "methods", "text": "The multifaceted intervention includes an evidence-based clinical pathway , written care protocols , a quality coordinator , and a monitoring and feedback system of performance measures .", "sentence_id": 4}
+{"abstract_id": "26027613", "label": "methods", "text": "The number of enrolled patients in the trial will be @,@ .", "sentence_id": 5}
+{"abstract_id": "26027613", "label": "methods", "text": "Primary outcome is the measure of the adherence to AIS evidence-based performance measures including the composite measure ( defined as the total number of interventions performed among eligible patients divided by the total number of possible interventions among eligible patients ) and the all-or-none measure ( defined as the proportion of eligible patients who receive all of the performance measure interventions for which they are eligible ) .", "sentence_id": 6}
+{"abstract_id": "26027613", "label": "methods", "text": "Secondary patient outcomes include inhospital death ; a new vascular event ; disability ; and all-cause death at @ , @ , and @ months after initial symptom onset .", "sentence_id": 7}
+{"abstract_id": "26027613", "label": "methods", "text": "All analyses will be performed according to the intention-to-treatment principle and accounted for clustering using generalized estimating equations .", "sentence_id": 8}
+{"abstract_id": "26027613", "label": "conclusions", "text": "If proven effective , this targeted multifaceted intervention model will be extended nationwide as a model to bridge the evidence-based gap in the AIS management in China .", "sentence_id": 9}
+{"abstract_id": "24906040", "label": "objective", "text": "Administration of secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancreatography ( MRCP ) .", "sentence_id": 0}
+{"abstract_id": "24906040", "label": "objective", "text": "We performed a large prospective study to investigate whether synthetic human secretin ( RG@ ) - stimulated MRCP detects pancreatic duct abnormalities with higher levels of sensitivity than MRCP .", "sentence_id": 1}
+{"abstract_id": "24906040", "label": "methods", "text": "We performed a phase @ , multicenter , baseline-controlled study of patients with acute or acute recurrent pancreatitis who were scheduled to undergo endoscopic retrograde cholangiopancreatography ( ERCP ) between March @ , @ , and October @ , @ .", "sentence_id": 2}
+{"abstract_id": "24906040", "label": "methods", "text": "Patients underwent a baseline MRCP that was immediately followed by administration of RG@ and repeat MRCP and then underwent ERCP within @ days ; they were followed up for @ days .", "sentence_id": 3}
+{"abstract_id": "24906040", "label": "methods", "text": "MRCP and ERCP images were read centrally by @ radiologists and @ endoscopists , respectively , who were all independent and blinded ; pancreatic duct abnormalities were evaluated .", "sentence_id": 4}
+{"abstract_id": "24906040", "label": "methods", "text": "The accuracy of MRCP was evaluated using ERCP as the standard .", "sentence_id": 5}
+{"abstract_id": "24906040", "label": "results", "text": "In total , @ patients were enrolled in the study ; @ MRCP image sets were assessed , and @ patients had evaluable ERCPs .", "sentence_id": 6}
+{"abstract_id": "24906040", "label": "results", "text": "Pancreatic duct abnormalities were observed in @ % of ERCP images .", "sentence_id": 7}
+{"abstract_id": "24906040", "label": "results", "text": "All radiologists identified duct abnormalities in RG@-cin MRCP image sets with significantly higher levels of sensitivity ( P < @ ) than in images from MRCP , with minimal loss of specificity .", "sentence_id": 8}
+{"abstract_id": "24906040", "label": "results", "text": "Adverse events were reported in @ % of patients after MRCP and @ % after ERCP .", "sentence_id": 9}
+{"abstract_id": "24906040", "label": "results", "text": "Of the @ patients who experienced a serious adverse event , @ ( @ % ) and @ ( @ % ) of the events were reported to be temporally associated with MRCP and ERCP , respectively .", "sentence_id": 10}
+{"abstract_id": "24906040", "label": "results", "text": "The adverse events most frequently considered related to RG@ were nausea , abdominal pain , and flushing ; most were mild .", "sentence_id": 11}
+{"abstract_id": "24906040", "label": "conclusions", "text": "Compared with images from MRCP , those from RG@-stimulated MRCP are improved in many aspects and could aid in diagnosis and clinical decision making for patients with acute , acute recurrent , or chronic pancreatitis .", "sentence_id": 12}
+{"abstract_id": "24906040", "label": "conclusions", "text": "RG@-enhanced MRCP might also better identify patients in need of therapeutic ERCP ( ClinicalTrials.gov , Number : NCT@ ) .", "sentence_id": 13}
+{"abstract_id": "24383441", "label": "background", "text": "Stress , depression , and anxiety affect @ % to @ % of pregnant women .", "sentence_id": 0}
+{"abstract_id": "24383441", "label": "background", "text": "However , substantial barriers to psychosocial assessment exist , resulting in less than @ % of prenatal care providers assessing and treating mental health problems .", "sentence_id": 1}
+{"abstract_id": "24383441", "label": "background", "text": "Moreover , pregnant women are often reluctant to disclose their mental health concerns to a healthcare provider .", "sentence_id": 2}
+{"abstract_id": "24383441", "label": "background", "text": "Identifying screening and assessment tools and procedures that are acceptable to both women and service providers , cost-effective , and clinically useful is needed .", "sentence_id": 3}
+{"abstract_id": "24383441", "label": "methods", "text": "The primary objective of this randomized , parallel-group , superiority trial is to evaluate the feasibility and acceptability of a computer tablet-based prenatal psychosocial assessment ( e-screening ) compared to paper-based screening .", "sentence_id": 4}
+{"abstract_id": "24383441", "label": "methods", "text": "Secondary objectives are to compare the two modes of screening on : ( @ ) the level of detection of prenatal depression and anxiety symptoms and psychosocial risk ; ( @ ) the level of disclosure of symptoms ; ( @ ) the factors associated with feasibility , acceptability , and disclosure ; ( @ ) the psychometric properties of the e-version of the assessment tools ; and ( @ ) cost-effectiveness .", "sentence_id": 5}
+{"abstract_id": "24383441", "label": "methods", "text": "A sample of @ women will be recruited from large , primary care maternity clinics and a high-risk antenatal unit in an urban Canadian city .", "sentence_id": 6}
+{"abstract_id": "24383441", "label": "methods", "text": "Pregnant women are eligible to participate if they : ( @ ) receive care at one of the recruitment sites ; ( @ ) are able to speak/read English ; ( @ ) are willing to be randomized to e-screening ; and ( @ ) are willing to participate in a follow-up diagnostic interview within @ week of recruitment .", "sentence_id": 7}
+{"abstract_id": "24383441", "label": "methods", "text": "Allocation is by computer-generated randomization .", "sentence_id": 8}
+{"abstract_id": "24383441", "label": "methods", "text": "Women in the intervention group will complete an online psychosocial assessment on a computer tablet , while those in the control group will complete the same assessment in paper-based form .", "sentence_id": 9}
+{"abstract_id": "24383441", "label": "methods", "text": "All women will complete baseline questionnaires at the time of recruitment and will participate in a diagnostic interview within @ week of recruitment .", "sentence_id": 10}
+{"abstract_id": "24383441", "label": "methods", "text": "Research assistants conducting diagnostic interviews and physicians will be blinded .", "sentence_id": 11}
+{"abstract_id": "24383441", "label": "methods", "text": "A qualitative descriptive study involving healthcare providers from the recruitment sites and women will provide data on feasibility and acceptability of the intervention .", "sentence_id": 12}
+{"abstract_id": "24383441", "label": "methods", "text": "We hypothesize that mental health e-screening in primary care maternity settings and high-risk antenatal units will be as or more feasible , acceptable , and capable of detecting depression , anxiety , and psychosocial risk compared to paper-based screening .", "sentence_id": 13}
+{"abstract_id": "24687829", "label": "objective", "text": "To determine the effects of bevacizumab on patient-reported outcomes ( PROs ; secondary end point ) in the AURELIA trial .", "sentence_id": 0}
+{"abstract_id": "24687829", "label": "methods", "text": "Patients with platinum-resistant ovarian cancer were randomly assigned to chemotherapy alone ( CT ) or with bevacizumab ( BEV-CT ) .", "sentence_id": 1}
+{"abstract_id": "24687829", "label": "methods", "text": "PROs were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Ovarian Cancer Module @ ( EORTC QLQ-OV@ ) and Functional Assessment of Cancer Therapy-Ovarian Cancer symptom index ( FOSI ) at baseline and every two or three cycles ( @/@ weeks ) until disease progression .", "sentence_id": 2}
+{"abstract_id": "24687829", "label": "methods", "text": "The primary PRO hypothesis was that more patients receiving BEV-CT than CT would achieve at least a @ % ( @-point ) absolute improvement on the QLQ-OV@ abdominal/GI symptom subscale ( items @-@ ) at week @/@ .", "sentence_id": 3}
+{"abstract_id": "24687829", "label": "methods", "text": "Patients with missing week @/@ questionnaires were included as unimproved .", "sentence_id": 4}
+{"abstract_id": "24687829", "label": "methods", "text": "Questionnaires from all assessments until disease progression were analyzed using mixed-model repeated-measures ( MMRM ) analysis .", "sentence_id": 5}
+{"abstract_id": "24687829", "label": "methods", "text": "Sensitivity analyses were used to determine the effects of differing assumptions and methods for missing data .", "sentence_id": 6}
+{"abstract_id": "24687829", "label": "results", "text": "Baseline questionnaires were available from @ % of @ randomly assigned patients .", "sentence_id": 7}
+{"abstract_id": "24687829", "label": "results", "text": "More BEV-CT than CT patients achieved a @ % improvement in abdominal/GI symptoms at week @/@ ( primary PRO end point , @ % v @ % ; difference , @ % ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24687829", "label": "results", "text": "MMRM analysis covering all time points also favored BEV-CT ( difference , @ points ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24687829", "label": "results", "text": "More BEV-CT than CT patients achieved @ % improvement in FOSI at week @/@ ( @ % v @ % ; difference , @ % ; @ % CI , @ % to @ % ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24687829", "label": "results", "text": "Sensitivity analyses gave similar results and conclusions .", "sentence_id": 11}
+{"abstract_id": "24687829", "label": "conclusions", "text": "Bevacizumab increased the proportion of patients achieving a @ % improvement in patient-reported abdominal/GI symptoms during chemotherapy for platinum-resistant ovarian cancer .", "sentence_id": 12}
+{"abstract_id": "25281300", "label": "background", "text": "Breastfeeding is associated with significant positive health outcomes for mothers and infants .", "sentence_id": 0}
+{"abstract_id": "25281300", "label": "background", "text": "However , despite recommendations from the World Health Organization , exclusive breastfeeding for six months is uncommon .", "sentence_id": 1}
+{"abstract_id": "25281300", "label": "background", "text": "Increased breastfeeding support early in the postpartum period may be effective in improving breastfeeding maintenance .", "sentence_id": 2}
+{"abstract_id": "25281300", "label": "background", "text": "This trial will evaluate two community-based interventions to increase breastfeeding duration in Local Government Areas ( LGAs ) in Victoria , Australia .", "sentence_id": 3}
+{"abstract_id": "25281300", "label": "methods", "text": "A three-arm cluster randomised controlled trial design will be used .", "sentence_id": 4}
+{"abstract_id": "25281300", "label": "methods", "text": "Victorian LGAs with a lower than average rate of any breastfeeding at discharge from hospital and more than @ births per year that agree to participate will be randomly allocated to one of three trial arms : @ ) standard care ; @ ) home-based breastfeeding support ; or @ ) home-based breastfeeding support plus access to a community-based breastfeeding drop-in centre .", "sentence_id": 5}
+{"abstract_id": "25281300", "label": "methods", "text": "The services provided in LGAs allocated to ` standard care ' are those routinely available to postpartum women .", "sentence_id": 6}
+{"abstract_id": "25281300", "label": "methods", "text": "LGAs allocated to the home-based visiting intervention will provide home-visits to women who are identified as at risk of breastfeeding cessation in the early postnatal period .", "sentence_id": 7}
+{"abstract_id": "25281300", "label": "methods", "text": "These visits will be provided by Maternal and Child Health Nurses who have received training to provide the intervention ( SILC-MCHNs ) .", "sentence_id": 8}
+{"abstract_id": "25281300", "label": "methods", "text": "In areas allocated to receive the second intervention , in addition to home-based breastfeeding support , community breastfeeding drop-in centres will be made available , staffed by a SILC-MCHN .", "sentence_id": 9}
+{"abstract_id": "25281300", "label": "methods", "text": "The interventions will run in LGAs for a nine to twelve month period depending on birth numbers .", "sentence_id": 10}
+{"abstract_id": "25281300", "label": "methods", "text": "The primary outcome is the proportion of infants receiving any breast milk at four months of age .", "sentence_id": 11}
+{"abstract_id": "25281300", "label": "methods", "text": "Breastfeeding outcomes will be obtained from routinely collected Maternal and Child Health centre data and from a new data item collecting infant feeding ` in the last @ hours ' .", "sentence_id": 12}
+{"abstract_id": "25281300", "label": "methods", "text": "Information will also be obtained directly from women via a postal survey .", "sentence_id": 13}
+{"abstract_id": "25281300", "label": "methods", "text": "A comprehensive process evaluation will be conducted .", "sentence_id": 14}
+{"abstract_id": "25281300", "label": "conclusions", "text": "This study will determine if early home-based breastfeeding support by a health professional for women at risk of stopping breastfeeding , with or without access to a community-based breastfeeding drop-in centre , increases breastfeeding duration in Victorian LGAs with low breastfeeding rates .", "sentence_id": 15}
+{"abstract_id": "26093872", "label": "background", "text": "Insulin-resistant states , including type @ diabetes ( T@D ) and prediabetes , are associated with elevated cardiovascular ( CV ) risk .", "sentence_id": 0}
+{"abstract_id": "26093872", "label": "background", "text": "Aleglitazar is a dual peroxisome proliferator-activated receptor / agonist with favorable insulin-sensitizing and glucose-lowering actions , favorable effects on blood lipids , and an acceptable safety profile in short-time studies .", "sentence_id": 1}
+{"abstract_id": "26093872", "label": "background", "text": "Therefore , it was hypothesized that aleglitazar would reduce CV morbidity and mortality in patients with T@D mellitus and prediabetes ( defined as glycosylated hemoglobin @ % to < @ % ) with previous CV complications .", "sentence_id": 2}
+{"abstract_id": "26093872", "label": "methods", "text": "ALEPREVENT was a phase III , multicenter , randomized , double-blind , trial comparing aleglitazar @ g or placebo daily in patients with T@D or prediabetes with established , stable CV disease .", "sentence_id": 3}
+{"abstract_id": "26093872", "label": "methods", "text": "The intended sample size was @,@ with a primary efficacy measure of major adverse CV events .", "sentence_id": 4}
+{"abstract_id": "26093872", "label": "methods", "text": "However , the trial was halted prematurely after @,@ patients had been randomized because of futility and an unfavorable benefit risk ratio in another CV outcomes trial evaluating aleglitazar .", "sentence_id": 5}
+{"abstract_id": "26093872", "label": "results", "text": "At study termination after @ @ days of treatment , data had been collected from @,@ patients ( @,@ with T@D and @ with pre-T@D ) .", "sentence_id": 6}
+{"abstract_id": "26093872", "label": "results", "text": "Despite the brief duration of treatment , aleglitazar induced favorable changes in glycosylated hemoglobin and blood lipids , similar for participants with T@D or prediabetes .", "sentence_id": 7}
+{"abstract_id": "26093872", "label": "results", "text": "However , compared with placebo , aleglitazar increased the incidence of hypoglycemia ( @ vs @ ; P < @ ) , and muscular events ( @ vs@ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26093872", "label": "conclusions", "text": "Even within a short duration of exposure , aleglitazar was associated with excess adverse events , corroborating the findings of a larger and longer trial in T@D .", "sentence_id": 9}
+{"abstract_id": "26093872", "label": "conclusions", "text": "Coupled with the previous failure of several other peroxisome proliferator-activated receptor / activators , this class now holds little promise for CV therapeutics .", "sentence_id": 10}
+{"abstract_id": "24760465", "label": "objective", "text": "Monopolar electrosurgery is the gold standard for surgical preparation in thoracoscopic spine procedures .", "sentence_id": 0}
+{"abstract_id": "24760465", "label": "objective", "text": "However , use of ultrasound scissors could decrease blood loss , accelerate the preparation time and improve patient safety , while minimizing operative costs .", "sentence_id": 1}
+{"abstract_id": "24760465", "label": "objective", "text": "This trial compares both preparation techniques for ventral thoracoscopic spondylodesis .", "sentence_id": 2}
+{"abstract_id": "24760465", "label": "methods", "text": "The study design is an open , prospective , randomized , and double-blinded two-armed clinical trial performed in two centres .", "sentence_id": 3}
+{"abstract_id": "24760465", "label": "methods", "text": "Forty-one patients with vertebral body fractures from T@ to L@ were included .", "sentence_id": 4}
+{"abstract_id": "24760465", "label": "methods", "text": "Primary endpoint : preparation time .", "sentence_id": 5}
+{"abstract_id": "24760465", "label": "methods", "text": "Secondary endpoints : blood loss , organ injuries , duration of hospitalization .", "sentence_id": 6}
+{"abstract_id": "24760465", "label": "results", "text": "Primary and secondary endpoints did not differ significantly between groups ( p level @ ) .", "sentence_id": 7}
+{"abstract_id": "24760465", "label": "results", "text": "Increased blood loss ( @ ml or more ) was eliminated with ultrasound scissors ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24760465", "label": "conclusions", "text": "Primary and secondary endpoints did not differ significantly between the two preparation techniques .", "sentence_id": 9}
+{"abstract_id": "24760465", "label": "conclusions", "text": "The use of either ultrasound scissors or electric scalpel offers safe and effective preparation for thoracoscopic spine surgery .", "sentence_id": 10}
+{"abstract_id": "24461612", "label": "background", "text": "Delirium is frequently diagnosed in critically ill patients and is associated with poor clinical outcomes .", "sentence_id": 0}
+{"abstract_id": "24461612", "label": "background", "text": "Haloperidol is the most commonly used drug for delirium despite little evidence of its effectiveness .", "sentence_id": 1}
+{"abstract_id": "24461612", "label": "background", "text": "The aim of this study was to establish whether early treatment with haloperidol would decrease the time that survivors of critical illness spent in delirium or coma .", "sentence_id": 2}
+{"abstract_id": "24461612", "label": "methods", "text": "We did this double-blind , placebo-controlled randomised trial in a general adult intensive care unit ( ICU ) .", "sentence_id": 3}
+{"abstract_id": "24461612", "label": "methods", "text": "Critically ill patients ( @ years ) needing mechanical ventilation within @ h of admission were enrolled .", "sentence_id": 4}
+{"abstract_id": "24461612", "label": "methods", "text": "Patients were randomised ( by an independent nurse , in @:@ ratio , with permuted block size of four and six , using a centralised , secure web-based randomisation service ) to receive haloperidol @ mg or @ % saline placebo intravenously every @ h , irrespective of coma or delirium status .", "sentence_id": 5}
+{"abstract_id": "24461612", "label": "methods", "text": "Study drug was discontinued on ICU discharge , once delirium-free and coma-free for @ consecutive days , or after a maximum of @ days of treatment , whichever came first .", "sentence_id": 6}
+{"abstract_id": "24461612", "label": "methods", "text": "Delirium was assessed using the confusion assessment method for the ICU ( CAM-ICU ) .", "sentence_id": 7}
+{"abstract_id": "24461612", "label": "methods", "text": "The primary outcome was delirium-free and coma-free days , defined as the number of days in the first @ days after randomisation during which the patient was alive without delirium and not in coma from any cause .", "sentence_id": 8}
+{"abstract_id": "24461612", "label": "methods", "text": "Patients who died within the @ day study period were recorded as having @ days free of delirium and coma .", "sentence_id": 9}
+{"abstract_id": "24461612", "label": "methods", "text": "ICU clinical and research staff and patients were masked to treatment throughout the study .", "sentence_id": 10}
+{"abstract_id": "24461612", "label": "methods", "text": "Analyses were by intention to treat .", "sentence_id": 11}
+{"abstract_id": "24461612", "label": "methods", "text": "This trial is registered with the International Standard Randomised Controlled Trial Registry , number ISRCTN@ .", "sentence_id": 12}
+{"abstract_id": "24461612", "label": "results", "text": "@ patients were randomised , @ were included in the final analysis ( @ haloperidol , @ placebo ) .", "sentence_id": 13}
+{"abstract_id": "24461612", "label": "results", "text": "Patients in the haloperidol group spent about the same number of days alive , without delirium , and without coma as did patients in the placebo group ( median @ days -LSB- IQR @-@ -RSB- vs @ days -LSB- @-@ -RSB- days ; p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24461612", "label": "results", "text": "The most common adverse events were oversedation ( @ patients in the haloperidol group vs six in the placebo group ) and QTc prolongation ( seven patients in the haloperidol group vs six in the placebo group ) .", "sentence_id": 15}
+{"abstract_id": "24461612", "label": "results", "text": "No patient had a serious adverse event related to the study drug .", "sentence_id": 16}
+{"abstract_id": "24461612", "label": "conclusions", "text": "These results do not support the hypothesis that haloperidol modifies duration of delirium in critically ill patients .", "sentence_id": 17}
+{"abstract_id": "24461612", "label": "conclusions", "text": "Although haloperidol can be used safely in this population of patients , pending the results of trials in progress , the use of intravenous haloperidol should be reserved for short-term management of acute agitation .", "sentence_id": 18}
+{"abstract_id": "25389218", "label": "objective", "text": "A recently published study showed the safety and efficacy of LSD-assisted psychotherapy in patients with anxiety associated with life-threatening diseases .", "sentence_id": 0}
+{"abstract_id": "25389218", "label": "objective", "text": "Participants of this study were included in a prospective follow-up .", "sentence_id": 1}
+{"abstract_id": "25389218", "label": "methods", "text": "@ months after finishing LSD psychotherapy , @ participants were tested for anxiety ( STAI ) and participated in a semi-structured interview .", "sentence_id": 2}
+{"abstract_id": "25389218", "label": "methods", "text": "A Qualitative Content Analysis ( QCA ) was carried out on the interviews to elaborate about LSD effects and lasting psychological changes .", "sentence_id": 3}
+{"abstract_id": "25389218", "label": "results", "text": "None of the participants reported lasting adverse reactions .", "sentence_id": 4}
+{"abstract_id": "25389218", "label": "results", "text": "The significant benefits as measured with the STAI were sustained over a @-month period .", "sentence_id": 5}
+{"abstract_id": "25389218", "label": "results", "text": "In the QCA participants consistently reported insightful , cathartic and interpersonal experiences , accompanied by a reduction in anxiety ( @ % ) and a rise in quality of life ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25389218", "label": "results", "text": "Evaluations of subjective experiences suggest facilitated access to emotions , confrontation of previously unknown anxieties , worries , resources and intense emotional peak experiences la Maslow as major psychological working mechanisms .", "sentence_id": 7}
+{"abstract_id": "25389218", "label": "results", "text": "The experiences created led to a restructuring of the person 's emotional trust , situational understanding , habits and world view .", "sentence_id": 8}
+{"abstract_id": "25389218", "label": "conclusions", "text": "LSD administered in a medically supervised psychotherapeutic setting can be safe and generate lasting benefits in patients with a life-threatening disease .", "sentence_id": 9}
+{"abstract_id": "25389218", "label": "conclusions", "text": "Explanatory models for the therapeutic effects of LSD warrant further study .", "sentence_id": 10}
+{"abstract_id": "24837141", "label": "objective", "text": "This study aimed to evaluate the effectiveness of a static ground reaction ankle foot orthosis and strapping system on improving gait parameters in children with spastic diplegic cerebral palsy .", "sentence_id": 0}
+{"abstract_id": "24837141", "label": "methods", "text": "The current study was conducted at the physical therapy faculty of Cairo University , Egypt .", "sentence_id": 1}
+{"abstract_id": "24837141", "label": "methods", "text": "This study included @ children of both sexes , aged @ to @ years .", "sentence_id": 2}
+{"abstract_id": "24837141", "label": "methods", "text": "Three-armed randomized control trial .", "sentence_id": 3}
+{"abstract_id": "24837141", "label": "methods", "text": "Participants in all groups received a traditional neuro-developmental physical therapy program that included standing and gait training exercises .", "sentence_id": 4}
+{"abstract_id": "24837141", "label": "methods", "text": "Children in group A performed the training program without any orthotic management , in group B with the TheraTogs strapping system , and in group C with the TheraTogs strapping system and static ground reaction ankle foot orthoses .", "sentence_id": 5}
+{"abstract_id": "24837141", "label": "methods", "text": "Children underwent treatment for two hours daily , except on weekends , for twelve successive weeks .", "sentence_id": 6}
+{"abstract_id": "24837141", "label": "methods", "text": "Gait speed , cadence , stride length , and hip and knee flexion angles in the mid-stance phase were evaluated pre-and post-treatment using a three-dimensional motion analysis system ( pre-reflex system ) .", "sentence_id": 7}
+{"abstract_id": "24837141", "label": "results", "text": "Statistically significant differences were recorded among the three groups post-treatment in gait speed , cadences , and stride length .", "sentence_id": 8}
+{"abstract_id": "24837141", "label": "results", "text": "The P-values for these variable differences were @ , @ , and @ respectively .", "sentence_id": 9}
+{"abstract_id": "24837141", "label": "results", "text": "Significant post-treatment differences were also recorded for bilateral hip-and knee-flexion angles .", "sentence_id": 10}
+{"abstract_id": "24837141", "label": "results", "text": "For all measured parameters , better significant results were registered for group C than for the other groups .", "sentence_id": 11}
+{"abstract_id": "24837141", "label": "conclusions", "text": "Orthotic intervention composed of a static ground reaction ankle foot orthosis combined with the TheraTogs strapping system improves gait more than conventional treatment with or without TheraTogs in children with spastic diplegic cerebral palsy .", "sentence_id": 12}
+{"abstract_id": "24727897", "label": "background", "text": "To investigate if the cramp threshold frequency ( CTF ) can be altered by electrical muscle stimulation in a shortened position .", "sentence_id": 0}
+{"abstract_id": "24727897", "label": "methods", "text": "A total of @ healthy male sport students were randomly allocated to an intervention ( IG , n = @ ) and a non-treatment control group ( CG , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24727897", "label": "methods", "text": "Calf muscles of both legs in the IG were stimulated equally twice a week over @ weeks .", "sentence_id": 2}
+{"abstract_id": "24727897", "label": "methods", "text": "The protocol was @ s on , @ s off , @ s impulse width , @ Hz above the individual CTF , and was at @ % of the maximal tolerated stimulation energy .", "sentence_id": 3}
+{"abstract_id": "24727897", "label": "methods", "text": "One leg was stimulated in a shortened position , inducing muscle cramps ( CT ) , while the opposite leg was fixated in a neutral position at the ankle , hindering muscle cramps ( nCT ) .", "sentence_id": 4}
+{"abstract_id": "24727897", "label": "methods", "text": "CTF tests were performed prior to the first and @ h after the @ ( th ) ( @ w ) and @ ( th ) ( @ w ) training session .", "sentence_id": 5}
+{"abstract_id": "24727897", "label": "results", "text": "After @ w , the CTF had significantly ( p < @ ) increased in CT calves from @ Hz to @ Hz , while it remained unchanged in nCT ( pre : @ Hz , mid : @ Hz ) and in both legs of the CG ( pre : @ Hz , mid : @ Hz ) .", "sentence_id": 6}
+{"abstract_id": "24727897", "label": "results", "text": "Only CT saw further insignificant increases in the CTF .", "sentence_id": 7}
+{"abstract_id": "24727897", "label": "results", "text": "The applied stimulation energy ( mA s ) positively correlated with the effect on the CTF ( r = @ ; p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24727897", "label": "conclusions", "text": "The present study may be useful for developing new non-pharmacological strategies to reduce cramp susceptibility .", "sentence_id": 9}
+{"abstract_id": "25238659", "label": "objective", "text": "To determine the effects of addition of different dosages of gonadotrophin releasing hormone agonist ( GnRH-a ) to routine luteal phase support ( LPS ) on implantation and pregnancy rates .", "sentence_id": 0}
+{"abstract_id": "25238659", "label": "methods", "text": "Three hundred infertile couples who were treated by intracytoplasmic sperm injection and embryo transfer ( ICSI-ET ) following controlled ovarian stimulation ( COS ) with long luteal GnRH agonist protocol were enrolled .", "sentence_id": 1}
+{"abstract_id": "25238659", "label": "methods", "text": "All women received @ mg/day vaginal micronized progesterone plus @ mg @ estradiol for LPS starting from the day of oocyte retrieval .", "sentence_id": 2}
+{"abstract_id": "25238659", "label": "methods", "text": "Patients ( n = @ ) were randomized into three treatment groups .", "sentence_id": 3}
+{"abstract_id": "25238659", "label": "methods", "text": "Group A ( n = @ ) received leuprolide acetate @ mg s.c. injection @ days after ET in addition to routine LPS .", "sentence_id": 4}
+{"abstract_id": "25238659", "label": "methods", "text": "Group B ( n = @ ) received two sequential doses of leuprolide acetate @ mg s.c. injections @ and @ days after ET in addition to routine LPS .", "sentence_id": 5}
+{"abstract_id": "25238659", "label": "methods", "text": "Control group ( n = @ ) received only the routine LPS .", "sentence_id": 6}
+{"abstract_id": "25238659", "label": "results", "text": "A total of @ patients completed the study .", "sentence_id": 7}
+{"abstract_id": "25238659", "label": "results", "text": "The groups were comparable in terms of baseline demographic parameters including age , duration of infertility and day @ levels of FSH and estradiol .", "sentence_id": 8}
+{"abstract_id": "25238659", "label": "results", "text": "The cycle parameters of the groups were also comparable regarding the E@ level on day of hCG , number of retrieved oocytes , number of day @ embryos , number of embryos transferred , and endometrial thickness on both days of OPU and ET .", "sentence_id": 9}
+{"abstract_id": "25238659", "label": "results", "text": "The implantation rates were similar in between the Groups A , B , and control group ( @ % and @ % vs. @ % , respectively ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25238659", "label": "results", "text": "The clinical pregnancy rates and miscarriage rates were similar in between the groups .", "sentence_id": 11}
+{"abstract_id": "25238659", "label": "results", "text": "The ongoing pregnancy rates were @ % in control group , @ % in Group A and @ % in Group B ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25238659", "label": "results", "text": "The OHSS rates were comparable in between the groups .", "sentence_id": 13}
+{"abstract_id": "25238659", "label": "results", "text": "The multiple pregnancy rates were significantly higher in Groups A and B than in control group ( @ % and @ % vs. @ % , respectively ; P = @ ) .", "sentence_id": 14}
+{"abstract_id": "25238659", "label": "conclusions", "text": "The implantation , clinical pregnancy and ongoing pregnancy and multiple pregnancy rates seem to be increased with the addition of GnRH-a to routine luteal phase support .", "sentence_id": 15}
+{"abstract_id": "24572452", "label": "objective", "text": "Obesity-induced chronic inflammation is a key component of the pathogenesis of insulin resistance .", "sentence_id": 0}
+{"abstract_id": "24572452", "label": "objective", "text": "Mounting evidence has demonstrated anti-inflammatory characteristics for vitamin D. Although analogues of vitamin D@ have extensively been used in the treatment of various chronic inflammatory diseases , to our knowledge , no such research is conducted in regards with obesity .", "sentence_id": 1}
+{"abstract_id": "24572452", "label": "objective", "text": "The aim of this double blind clinical trial study is to investigate whether alphacalcidol treatment in obese subjects can affect the cytokine profile and insulin resistance .", "sentence_id": 2}
+{"abstract_id": "24572452", "label": "objective", "text": "Moreover , we evaluated the pathways of vitamin D receptor ( VDR ) , PPAR and PGC@ gene expressions which may lead to insulin resistance following treatment with either alphacalcidol or placebo .", "sentence_id": 3}
+{"abstract_id": "24572452", "label": "methods", "text": "A total of @ obese participants ( BMI@ ) were recruited for the current double blind clinical trial study .", "sentence_id": 4}
+{"abstract_id": "24572452", "label": "methods", "text": "Patients were divided into two intervention ( N. = @ ) and control groups ( N. = @ ) based on the stratified randomized method .", "sentence_id": 5}
+{"abstract_id": "24572452", "label": "methods", "text": "One-Alpha Capsules @ microgram : alfacalcidol ( @ - hydroxyvitamin D@ ) and placebo were given to subjects once a day for @ weeks .", "sentence_id": 6}
+{"abstract_id": "24572452", "label": "methods", "text": "Analysis of body composition was performed with use of Body Composition Analyzer .", "sentence_id": 7}
+{"abstract_id": "24572452", "label": "methods", "text": "The circulating levels of TNF - , IL-@ , IL-@ , IL-@ , IL-@ , IL-@ , IL-@ , PTH , and @-Hydroxy Vi-tamin D were measured with the use of EIA method .", "sentence_id": 8}
+{"abstract_id": "24572452", "label": "methods", "text": "The PBMCs were separated from whole blood by Ficoll-hypaque technique .", "sentence_id": 9}
+{"abstract_id": "24572452", "label": "methods", "text": "Total cellular RNA was extracted and the cDNA was synthesized .", "sentence_id": 10}
+{"abstract_id": "24572452", "label": "methods", "text": "The real-time PCR using specific primer pairs for VDR , PGC@ , PPAR , and - actin was performed .", "sentence_id": 11}
+{"abstract_id": "24572452", "label": "results", "text": "The FPG , fat percent and PTH levels were decreased and the levels of HDL-cholesterol and @-hydroxy vitamin D were significantly increased after treatment with Alfacalcidol .", "sentence_id": 12}
+{"abstract_id": "24572452", "label": "results", "text": "Regarding to cytokines levels , the levels of IL@ were significantly decreased and IL@ were significantly increased in Alfacalcidol group in comparison with the control group .", "sentence_id": 13}
+{"abstract_id": "24572452", "label": "results", "text": "The relative expressions of VDR , PGC@ , and PPAR genes significantly increased in Alfacalcidol group .", "sentence_id": 14}
+{"abstract_id": "24572452", "label": "results", "text": "We found also significant positive correlation between circulating @-OH vitamin D and relative PGC@ gene expression in participants with insulin resistance .", "sentence_id": 15}
+{"abstract_id": "24572452", "label": "conclusions", "text": "It seems that Alfacalcidol treatment may be effective in amelioration of the inflammatory state in obesity .", "sentence_id": 16}
+{"abstract_id": "24572452", "label": "conclusions", "text": "This supplement might also improve resistance to insulin through enhancement of relative VDR and its downstream genes expression , which are demonstrated to be involved in glucose homeostasis pathways .", "sentence_id": 17}
+{"abstract_id": "24229360", "label": "background", "text": "Macrolides reduce exacerbations in patients with COPD .", "sentence_id": 0}
+{"abstract_id": "24229360", "label": "background", "text": "Their effects on health status has not been assessed as primary outcome and is less clear .", "sentence_id": 1}
+{"abstract_id": "24229360", "label": "background", "text": "This study assessed the effects of prophylactic azithromycin on cough-specific health status in COPD-patients with chronic productive cough .", "sentence_id": 2}
+{"abstract_id": "24229360", "label": "methods", "text": "In this randomised controlled trial @ patients met the eligibility criteria : age of @ years , COPD GOLD stage @ and chronic productive cough .", "sentence_id": 3}
+{"abstract_id": "24229360", "label": "methods", "text": "The intervention-group ( n = @ ) received azithromycin @ mg @ times a week and the control-group ( n = @ ) received a placebo .", "sentence_id": 4}
+{"abstract_id": "24229360", "label": "methods", "text": "Primary outcome was cough-specific health status at @ weeks , measured with the Leicester Cough Questionnaire ( LCQ ) .", "sentence_id": 5}
+{"abstract_id": "24229360", "label": "methods", "text": "Secondary outcomes included generic and COPD-specific health status and exacerbations .", "sentence_id": 6}
+{"abstract_id": "24229360", "label": "methods", "text": "Changes in adverse events and microbiology were monitored .", "sentence_id": 7}
+{"abstract_id": "24229360", "label": "results", "text": "Mean age of participants was @ years and mean FEV@ was @ L.", "sentence_id": 8}
+{"abstract_id": "24229360", "label": "results", "text": "The improvement in LCQ total score at @ weeks was significantly greater with azithromycin ( difference @ , @ % CI @ ; @ , p = @ ) and met the minimal clinically important difference .", "sentence_id": 9}
+{"abstract_id": "24229360", "label": "results", "text": "Similar results were found for the domain scores , and COPD-specific and generic health status questionnaires .", "sentence_id": 10}
+{"abstract_id": "24229360", "label": "results", "text": "Other secondary endpoints were non-significant .", "sentence_id": 11}
+{"abstract_id": "24229360", "label": "results", "text": "No imbalances in adverse events were found .", "sentence_id": 12}
+{"abstract_id": "24229360", "label": "conclusions", "text": "Prophylactic azithromycin improved cough-specific health status in COPD-patients with chronic productive cough to a clinically relevant degree .", "sentence_id": 13}
+{"abstract_id": "25332329", "label": "background", "text": "High intake of cow-milk protein in formula-fed infants is associated with higher weight gain and increased adiposity , which have led to recommendations to limit protein intake in later infancy .", "sentence_id": 0}
+{"abstract_id": "25332329", "label": "background", "text": "The impact of protein from meats for breastfed infants during complementary feeding may be different .", "sentence_id": 1}
+{"abstract_id": "25332329", "label": "objective", "text": "We examined the effect of protein from meat as complementary foods on growth and metabolic profiles of breastfed infants .", "sentence_id": 2}
+{"abstract_id": "25332329", "label": "methods", "text": "This was a secondary analysis from a trial in which exclusively breastfed infants ( @-@ mo old from the Denver , CO , metro area ) were randomly assigned to receive commercially available pureed meats ( Meat group ; n = @ ) or infant cereal ( Cereal group ; n = @ ) as their primary complementary feedings for @ mo. .", "sentence_id": 3}
+{"abstract_id": "25332329", "label": "methods", "text": "Anthropometric measures and diet records were collected monthly from @ to @ mo of age ; intakes from complementary feeding and breast milk were assessed at @ mo of age .", "sentence_id": 4}
+{"abstract_id": "25332329", "label": "results", "text": "The Meat group had significantly higher protein intake , whereas energy , carbohydrate , and fat intakes from complementary feeding did not differ by group over time .", "sentence_id": 5}
+{"abstract_id": "25332329", "label": "results", "text": "At @ mo of age , mean ( SEM ) intakes of total ( complementary feeding plus breast milk ) protein were @ @ and @ @ g kg ( -@ ) d ( -@ ) , @ % and @ % of daily energy intake , for Meat and Cereal groups , respectively ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25332329", "label": "results", "text": "From @ to @ mo of age , the weight-for-age z score ( WAZ ) and length-for-age z score ( LAZ ) increased in the Meat group ( WAZ : @ @ ; LAZ : @ @ ) and decreased in the Cereal group ( WAZ : -@ @ ; LAZ : -@ @ ) ( P-group by time < @ ) .", "sentence_id": 7}
+{"abstract_id": "25332329", "label": "results", "text": "The change in weight-for-length z score did not differ between groups .", "sentence_id": 8}
+{"abstract_id": "25332329", "label": "results", "text": "Total protein intake at @ mo of age and baseline WAZ were important predictors of changes in the WAZ ( R ( @ ) = @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25332329", "label": "conclusions", "text": "In breastfed infants , higher protein intake from meats was associated with greater linear growth and weight gain but without excessive gain in adiposity , suggesting that potential risks of high protein intake may differ between breastfed and formula-fed infants and by the source of protein .", "sentence_id": 10}
+{"abstract_id": "25379850", "label": "objective", "text": "We aimed to examine the association between total number of resected nodes and survival in patients after esophagectomy with and without nCRT .", "sentence_id": 0}
+{"abstract_id": "25379850", "label": "background", "text": "Most studies concerning the potentially positive effect of extended lymphadenectomy on survival have been performed in patients who underwent surgery alone .", "sentence_id": 1}
+{"abstract_id": "25379850", "label": "background", "text": "As nCRT is known to frequently `` sterilize '' regional nodes , it is unclear whether extended lymphadenectomy after nCRT is still useful .", "sentence_id": 2}
+{"abstract_id": "25379850", "label": "methods", "text": "Patients from the randomized CROSS-trial who completed the entire protocol ( ie , surgery alone or chemoradiotherapy + surgery ) were included .", "sentence_id": 3}
+{"abstract_id": "25379850", "label": "methods", "text": "With Cox regression models , we compared the impact of number of resected nodes as well as resected positive nodes on survival in both groups .", "sentence_id": 4}
+{"abstract_id": "25379850", "label": "results", "text": "One hundred sixty-one patients underwent surgery alone , and @ patients received multimodality treatment .", "sentence_id": 5}
+{"abstract_id": "25379850", "label": "results", "text": "The median ( interquartile range ) number of resected nodes was @ ( @-@ ) and @ ( @-@ ) , with @ ( @-@ ) and @ ( @-@ ) resected positive nodes , respectively .", "sentence_id": 6}
+{"abstract_id": "25379850", "label": "results", "text": "Persistent lymph node positivity after nCRT had a greater negative prognostic impact on survival as compared with lymph node positivity after surgery alone .", "sentence_id": 7}
+{"abstract_id": "25379850", "label": "results", "text": "The total number of resected nodes was significantly associated with survival for patients in the surgery-alone arm ( hazard ratio per @ additionally resected nodes , @ ; P = @ ) , but not in the multimodality arm ( hazard ratio @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25379850", "label": "conclusions", "text": "The number of resected nodes had a prognostic impact on survival in patients after surgery alone , but its therapeutic value is still controversial .", "sentence_id": 9}
+{"abstract_id": "25379850", "label": "conclusions", "text": "After nCRT , the number of resected nodes was not associated with survival .", "sentence_id": 10}
+{"abstract_id": "25379850", "label": "conclusions", "text": "These data question the indication for maximization of lymphadenectomy after nCRT .", "sentence_id": 11}
+{"abstract_id": "24439644", "label": "objective", "text": "To examine the effects of foot reflexology massage on anxiety in patients following CABG surgery .", "sentence_id": 0}
+{"abstract_id": "24439644", "label": "methods", "text": "In this randomized controlled trial , @ patients who met the inclusion criteria were conveniently sampled and randomly allocated to the experimental and control groups after they were matched on age and gender .", "sentence_id": 1}
+{"abstract_id": "24439644", "label": "methods", "text": "On the days following surgery , the experimental group received foot reflexology massage on their left foot @mina day for @ days , while the control group was given a gentle foot rub with oil for one minute .", "sentence_id": 2}
+{"abstract_id": "24439644", "label": "methods", "text": "Anxiety was measured using the short-form of the Spielberger State-Trait Anxiety Inventory and the Visual Analogue Scale-Anxiety .", "sentence_id": 3}
+{"abstract_id": "24439644", "label": "results", "text": "Both measurement instruments confirmed a significant decrease in anxiety following the foot reflexology massage .", "sentence_id": 4}
+{"abstract_id": "24439644", "label": "conclusions", "text": "The significant decrease in anxiety in the experimental group following the foot reflexology massage supports the use of this complementary therapy technique for the relief of anxiety .", "sentence_id": 5}
+{"abstract_id": "25773557", "label": "objective", "text": "To estimate the effect of sequence on response precision and response behavior in health valuation studies .", "sentence_id": 0}
+{"abstract_id": "25773557", "label": "methods", "text": "Time trade-off ( TTO ) and paired comparison responses from six health valuation studies-four US , one Spanish , and one Dutch-were examined ( @,@ respondents ) to test whether task sequence influences response precision ( e.g. , rounding ) , response changes , and median response times .", "sentence_id": 1}
+{"abstract_id": "25773557", "label": "methods", "text": "Each study used a computer-based instrument that randomized task sequence among a national sample of adults , age @ years or older , from the general population .", "sentence_id": 2}
+{"abstract_id": "25773557", "label": "results", "text": "For both TTO and paired comparisons , median response times decreased with sequence ( i.e. , learning ) , but tended to flatten after the first three tasks .", "sentence_id": 3}
+{"abstract_id": "25773557", "label": "results", "text": "Although the paired comparison evidence demonstrated that sequence had no effect on response precision , the frequency of rounded TTO responses ( to either @-year or @-year units ) increased with sequence .", "sentence_id": 4}
+{"abstract_id": "25773557", "label": "conclusions", "text": "Based on these results , randomizing or reducing the number of paired comparison tasks does not appear to influence response precision ; however , generalizability , practicality , and precautionary considerations remain .", "sentence_id": 5}
+{"abstract_id": "25773557", "label": "conclusions", "text": "Overall , participants learned to respond efficiently within the first three tasks and did not resort to satisficing , but may have rounded their TTO responses .", "sentence_id": 6}
+{"abstract_id": "24704117", "label": "objective", "text": "Bulkamid is a new polyacrylamide hydrogel bulking agent for stress urinary incontinence that is injected in the urethral submucosa using a specifically designed device .", "sentence_id": 0}
+{"abstract_id": "24704117", "label": "objective", "text": "We evaluated the safety and efficacy of Bulkamid vs Contigen collagen gel for stress urinary incontinence or stress predominant mixed urinary incontinence .", "sentence_id": 1}
+{"abstract_id": "24704117", "label": "methods", "text": "This was a single-blind , randomized , prospective , @-center , @-arm parallel study of hydrogel vs collagen gel with followup to @year .", "sentence_id": 2}
+{"abstract_id": "24704117", "label": "methods", "text": "At baseline patients underwent physical examination and bladder testing , and completed quality of life questionnaires and bladder diaries .", "sentence_id": 3}
+{"abstract_id": "24704117", "label": "methods", "text": "After randomization patients could receive up to @ injections at @-month intervals .", "sentence_id": 4}
+{"abstract_id": "24704117", "label": "methods", "text": "Patients were assessed @ , @ , @ and @ months after bulking .", "sentence_id": 5}
+{"abstract_id": "24704117", "label": "methods", "text": "They completed bladder diaries and quality of life questionnaires , and pad weight was tested .", "sentence_id": 6}
+{"abstract_id": "24704117", "label": "methods", "text": "Atthe last visit Valsalva leak point pressure was measured .", "sentence_id": 7}
+{"abstract_id": "24704117", "label": "methods", "text": "Subjective and objective incontinence outcomes and adverse events were compared .", "sentence_id": 8}
+{"abstract_id": "24704117", "label": "results", "text": "Of the @ women @ were randomized to hydrogel and @ were randomized to collagen gel .", "sentence_id": 9}
+{"abstract_id": "24704117", "label": "results", "text": "At @ months a @ % or greater decrease in leakage and incontinence episodes was seen in @ % and @ % of patients who received hydrogel and collagen gel , respectively .", "sentence_id": 10}
+{"abstract_id": "24704117", "label": "results", "text": "At @ months @ % of patients with hydrogel and @ % with collagen gel reported zero stress incontinence episodes , and @ % and @ % , respectively , considered themselves cured or improved .", "sentence_id": 11}
+{"abstract_id": "24704117", "label": "results", "text": "Major adverse events were rare in each group .", "sentence_id": 12}
+{"abstract_id": "24704117", "label": "conclusions", "text": "Bulkamid is not inferior to Contigen .", "sentence_id": 13}
+{"abstract_id": "24704117", "label": "conclusions", "text": "It has a favorable , persistent effect on stress urinary incontinence with a low risk of serious adverse events .", "sentence_id": 14}
+{"abstract_id": "24704117", "label": "conclusions", "text": "Bulkamid is a new , simple , office based bulking system that shows promise asatreatment in women with stress urinary incontinence , particularly since Contigen is no longer commercially available .", "sentence_id": 15}
+{"abstract_id": "25300885", "label": "objective", "text": "Most problematic alcohol users never seek professional help to reduce their use , and Web-based interventions might fulfill users ' unmet needs for professional support .", "sentence_id": 0}
+{"abstract_id": "25300885", "label": "methods", "text": "This randomized controlled trial compared two open Web-based interventions , one extended self-help program and one brief screening and feedback intervention , with an assessment-only control group .", "sentence_id": 1}
+{"abstract_id": "25300885", "label": "methods", "text": "Participants were @ Internet help seekers with at least hazardous alcohol use ( Alcohol Use Disorders Identification Test , AUDIT @ for women and @ for men ) .", "sentence_id": 2}
+{"abstract_id": "25300885", "label": "results", "text": "All groups reduced their alcohol use at @-month follow-up ( p < @ ) , remaining stable at the @ - and @-month follow-ups ( n.s. ) according to AUDIT-C and AUDIT scores ( intention-to-treat , ITT , analysis ) .", "sentence_id": 3}
+{"abstract_id": "25300885", "label": "results", "text": "Per protocol ( PP ) analysis , including only participants who accessed the interventions and also reported accessing additional outside interventions during the trial , showed that about @ % of extended self-help participants moved from probable dependence , harmful or hazardous use to lower alcohol use levels at @ - and @ - and @-month follow-ups , compared to about @-@ % of brief intervention users and controls who accessed extra help ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25300885", "label": "conclusions", "text": "ITT analysis suggested parity over time for all interventions , including assessment only , in reducing problematic alcohol use .", "sentence_id": 5}
+{"abstract_id": "25300885", "label": "conclusions", "text": "In contrast , PP analysis suggested that cognitive-behavioral extended self-help in combination with other interventions was more effective in changing alcohol use than brief intervention or assessment only .", "sentence_id": 6}
+{"abstract_id": "24796059", "label": "objective", "text": "To compare the difference in the efficacy on cervical type of cervical spondylosis ( CS ) between the combined treatment of sword-like needle and chiropractic spinal manipulation ( the combined therapy ) and the simple chiropractic spinal manipulation .", "sentence_id": 0}
+{"abstract_id": "24796059", "label": "methods", "text": "One hundred and thirty-eight cases of cervical type of CS were randomized into a combined therapy group ( @ cases ) and a simple chiropractic spinal manipulation group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24796059", "label": "methods", "text": "In the combined therapy group , the sword-like needle therapy was applied at Fengchi ( GB @ ) , Tianzhu ( BL @ ) and Jiaji ( EX-B @ ) C@-C@ .", "sentence_id": 2}
+{"abstract_id": "24796059", "label": "methods", "text": "The chiropractic spinal manipulation was used in combination .", "sentence_id": 3}
+{"abstract_id": "24796059", "label": "methods", "text": "In the chiropractic spinal manipulation group , the simple chiropractic spinal manipulation was adopted .", "sentence_id": 4}
+{"abstract_id": "24796059", "label": "methods", "text": "The treatment was given once every other day in the two groups , @ days made one session .", "sentence_id": 5}
+{"abstract_id": "24796059", "label": "methods", "text": "One session of treatment was required .", "sentence_id": 6}
+{"abstract_id": "24796059", "label": "methods", "text": "Visual analog scale ( VAS ) score was observed before and after treatment in the two groups and the efficacies were compared between the two groups .", "sentence_id": 7}
+{"abstract_id": "24796059", "label": "results", "text": "VAS score after treatment was reduced obviously as compared with that before treatment in the patients of the two groups ( both P < @ ) and VAS score after treatment in the combined therapy group was lower than that in the simple chiropractic spinal manipulation group ( @ + / - @ vs @ + / -@ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24796059", "label": "results", "text": "In the combined therapy group , @ cases were cured , @ cases remarkably effective , @ cases improved and @ case failed .", "sentence_id": 9}
+{"abstract_id": "24796059", "label": "results", "text": "In the chiropractic spinal manipulation group , @ cases were cured , @ cases remarkably effective , @ cases improved and @ case failed .", "sentence_id": 10}
+{"abstract_id": "24796059", "label": "results", "text": "The overall efficacy in the combined therapy group was better than that in the chiropractic spinal manipulation ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24796059", "label": "conclusions", "text": "The sword-like needle therapy combined with chiropractic spinal manipulation relieve effectively pain in cervical type of CS and the efficacy is superior to the simple chiropractic spinal manipulation .", "sentence_id": 12}
+{"abstract_id": "24878085", "label": "background", "text": "Recently it has been reported a benefit effect with the use of metformin in patients with malignant disease .", "sentence_id": 0}
+{"abstract_id": "24878085", "label": "background", "text": "Our objective was to evaluate the effect of adding metformin to chemotherapy regimen over the percentage of early relapse in acute lymphoblastic leukemia .", "sentence_id": 1}
+{"abstract_id": "24878085", "label": "methods", "text": "A prospective , longitudinal and experimental study was performed in patients with de novo acute lymphoblastic leukemia enrolled in the Hospital General de Mxico .", "sentence_id": 2}
+{"abstract_id": "24878085", "label": "methods", "text": "They were divided in two groups : first group received chemotherapy + metformin ( @ mg three times a day ) ; second group only received standard chemotherapy .", "sentence_id": 3}
+{"abstract_id": "24878085", "label": "methods", "text": "The sample was randomized @:@ in favor of the second group .", "sentence_id": 4}
+{"abstract_id": "24878085", "label": "results", "text": "@ patients were included ( @ treated with chemotherapy + metformin and @ received standard chemotherapy ) , with @ @ days of follow-up .", "sentence_id": 5}
+{"abstract_id": "24878085", "label": "results", "text": "Complete remission was higher in the group without metformin ( @ % -LSB- n = @ -RSB- versus @ % -LSB- n = @ -RSB- ) , which also presented more patients with relapse ( @ % versus @ % ) .", "sentence_id": 6}
+{"abstract_id": "24878085", "label": "results", "text": "Overall survival at one year was of @ % and free survival disease was @ % , without significant differences between groups .", "sentence_id": 7}
+{"abstract_id": "24878085", "label": "results", "text": "Absence of metformin was the only variable of adverse prognostic considered significant ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24878085", "label": "results", "text": "Cox regression showed that adding metfomin reduced @ % the risk of relapse .", "sentence_id": 9}
+{"abstract_id": "24878085", "label": "conclusions", "text": "The adding metformin to the treatment of leukemias showed that was useful in our research .", "sentence_id": 10}
+{"abstract_id": "24878085", "label": "conclusions", "text": "However , randomized and double-blind studies must be designed in order to express final recommendations about its use .", "sentence_id": 11}
+{"abstract_id": "24384646", "label": "objective", "text": "To determine whether smaller brain volumes in older women who had completed Women 's Health Initiative ( WHI ) - assigned conjugated equine estrogen-based hormone therapy ( HT ) , reported by WHI Memory Study ( WHIMS ) - MRI , correspond to a continuing increased rate of atrophy an average of @ to @ years later in WHIMS-MRI@ .", "sentence_id": 0}
+{"abstract_id": "24384646", "label": "methods", "text": "A total of @,@ WHI participants were contacted : @ ( @ % ) consented , and @ ( @ % ) were rescanned an average of @ years after the initial MRI scan .", "sentence_id": 1}
+{"abstract_id": "24384646", "label": "methods", "text": "Mean annual rates of change in total brain volume , the primary outcome , and rates of change in ischemic lesion volumes , the secondary outcome , were compared between treatment groups using mixed-effect models with adjustment for trial , clinical site , age , intracranial volumes , and time between MRI measures .", "sentence_id": 2}
+{"abstract_id": "24384646", "label": "results", "text": "Total brain volume decreased an average of @ cm ( @ ) / y in the active arm and @ cm ( @ ) / y in the placebo arm ( p = @ ) .", "sentence_id": 3}
+{"abstract_id": "24384646", "label": "results", "text": "Total ischemic lesion volumes increased in both arms at a rate of @ cm ( @ ) / y ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24384646", "label": "conclusions", "text": "Conjugated equine estrogen-based postmenopausal HT , previously assigned at WHI baseline , did not affect rates of decline in brain volumes or increases in brain lesion volumes during the @ years between the initial and follow-up WHIMS-MRI studies .", "sentence_id": 5}
+{"abstract_id": "24384646", "label": "conclusions", "text": "Smaller frontal lobe volumes were observed as persistent group differences among women assigned to active HT compared with placebo .", "sentence_id": 6}
+{"abstract_id": "24384646", "label": "conclusions", "text": "Women with a history of cardiovascular disease treated with active HT , compared with placebo , had higher rates of accumulation in white matter lesion volume and total brain lesion volume .", "sentence_id": 7}
+{"abstract_id": "24384646", "label": "conclusions", "text": "Further study may elucidate mechanisms that explain these findings .", "sentence_id": 8}
+{"abstract_id": "26179814", "label": "background", "text": "Surgical patients are at risk of adverse drug events ( ADEs ) causing morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "26179814", "label": "background", "text": "Much harm is preventable .", "sentence_id": 1}
+{"abstract_id": "26179814", "label": "background", "text": "Ward-based pharmacy interventions to reduce medication-related harm have not been evaluated in surgical patients .", "sentence_id": 2}
+{"abstract_id": "26179814", "label": "methods", "text": "This multicentre prospective clinical trial evaluated a protocolled , ward-based pharmacy method compared with standard pharmaceutical care in surgical patients .", "sentence_id": 3}
+{"abstract_id": "26179814", "label": "methods", "text": "Allocation of study group was done by one-time randomization at ward level .", "sentence_id": 4}
+{"abstract_id": "26179814", "label": "methods", "text": "Consecutive patients admitted for elective surgery with an expected hospital stay longer than @ h were included .", "sentence_id": 5}
+{"abstract_id": "26179814", "label": "methods", "text": "Pharmacy practitioners performed bedside medication reconciliation at admission and discharge , and hospital pharmacists undertook regular medication reviews in the study wards .", "sentence_id": 6}
+{"abstract_id": "26179814", "label": "methods", "text": "Preventable ADEs and clinical outcomes were assessed .", "sentence_id": 7}
+{"abstract_id": "26179814", "label": "results", "text": "A total of @ surgical patients were studied .", "sentence_id": 8}
+{"abstract_id": "26179814", "label": "results", "text": "Some @ specific interventions were made by the hospital pharmacist to improve pharmacotherapy in @ of @ patients on study wards .", "sentence_id": 9}
+{"abstract_id": "26179814", "label": "results", "text": "A further @ patients were included on control wards .", "sentence_id": 10}
+{"abstract_id": "26179814", "label": "results", "text": "A crude non-significant reduction in incidence of preventable ADEs was seen on intervention wards in comparison with control wards ( @ versus @ preventable ADEs per @ admissions ; incidence rate ratio @ , @ per cent c.i. @ to @ ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "26179814", "label": "results", "text": "After adjustment for differences in treatment groups and for potential confounding , the incidence rate ratio remained non-significant ( @ , @ to @ ; P = @ ) .", "sentence_id": 12}
+{"abstract_id": "26179814", "label": "results", "text": "No differences were seen for other outcomes , such as duration of hospital stay , number of complications and quality of life .", "sentence_id": 13}
+{"abstract_id": "26179814", "label": "conclusions", "text": "The present prospective controlled trial showed no significant reduction in medication-related harm or changes in clinical outcomes when surgical patients received protocolled ward-based pharmacy interventions .", "sentence_id": 14}
+{"abstract_id": "25923552", "label": "background", "text": "The Diabetes Control and Complications Trial ( DCCT ) showed a beneficial effect of @ years of intensive glycemic control on retinopathy in patients with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25923552", "label": "methods", "text": "Between @ and @ , a total of @ patients with type @ diabetes in the DCCT were randomly assigned to receive either intensive diabetes therapy or conventional therapy aimed at preventing hyperglycemic symptoms .", "sentence_id": 1}
+{"abstract_id": "25923552", "label": "methods", "text": "They were treated and followed until @ .", "sentence_id": 2}
+{"abstract_id": "25923552", "label": "methods", "text": "Subsequently , @ of these patients were followed in the observational Epidemiology of Diabetes Interventions and Complications ( EDIC ) study .", "sentence_id": 3}
+{"abstract_id": "25923552", "label": "methods", "text": "The self-reported history of ocular surgical procedures was obtained annually .", "sentence_id": 4}
+{"abstract_id": "25923552", "label": "methods", "text": "We evaluated the effect of intensive therapy as compared with conventional therapy on the incidence and cost of ocular surgery during these two studies .", "sentence_id": 5}
+{"abstract_id": "25923552", "label": "results", "text": "Over a median follow-up of @ years , @ ocular operations were performed in @ of @ patients assigned to intensive therapy ( @ % ) and @ ocular operations in @ of @ patients assigned to conventional therapy ( @ % ) ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25923552", "label": "results", "text": "After adjustment for DCCT baseline factors , intensive therapy was associated with a reduction in the risk of any diabetes-related ocular surgery by @ % ( @ % confidence interval -LSB- CI -RSB- , @ to @ ; P < @ ) and a reduction in the risk of all such ocular procedures by @ % ( @ % CI , @ to @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25923552", "label": "results", "text": "Forty-two patients who received intensive therapy and @ who received conventional therapy underwent cataract extraction ( adjusted risk reduction with intensive therapy , @ % ; @ % CI , @ to @ ; P = @ ) ; @ patients who received intensive therapy and @ who received conventional therapy underwent vitrectomy , retinal-detachment surgery , or both ( adjusted risk reduction , @ % ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25923552", "label": "results", "text": "The costs of surgery were @ % lower in the intensive-therapy group .", "sentence_id": 9}
+{"abstract_id": "25923552", "label": "results", "text": "The beneficial effects of intensive therapy were fully attenuated after adjustment for mean glycated hemoglobin levels over the entire follow-up .", "sentence_id": 10}
+{"abstract_id": "25923552", "label": "conclusions", "text": "Intensive therapy in patients with type @ diabetes was associated with a substantial reduction in the long-term risk of ocular surgery .", "sentence_id": 11}
+{"abstract_id": "25923552", "label": "conclusions", "text": "( Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others ; DCCT/EDIC ClinicalTrials.gov numbers , NCT@ and NCT@ . )", "sentence_id": 12}
+{"abstract_id": "24792106", "label": "objective", "text": "To compare the safety and efficacy of microcoaxial phacoemulsification surgeries performed with the OZil Intelligent Phaco torsional mode ( Alcon Laboratories , Inc. , Fort Worth , USA ) and combined torsional/longitudinal ultrasound mode using @ degree aperture angled tips .", "sentence_id": 0}
+{"abstract_id": "24792106", "label": "methods", "text": "Prospective randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "24792106", "label": "methods", "text": "setting : Maltepe University , Istanbul .", "sentence_id": 2}
+{"abstract_id": "24792106", "label": "methods", "text": "patient population : Eighty eyes of @ cataract patients were randomly assigned to @ mm microcoaxial phacoemulsification using the OZil Intelligent Phaco torsional mode ( Group @ ) or combined torsional/longitudinal ultrasound mode ( Group @ ) .", "sentence_id": 3}
+{"abstract_id": "24792106", "label": "methods", "text": "observation procedure : Intraoperative fluid and energy usage and postoperative examinations were evaluated .", "sentence_id": 4}
+{"abstract_id": "24792106", "label": "methods", "text": "main outcome measures : Ultrasound time , cumulative dissipated energy , longitudinal and torsional ultrasound amplitudes , mean operation time , mean volume of fluid used , and surgical complications .", "sentence_id": 5}
+{"abstract_id": "24792106", "label": "results", "text": "Both groups included @ eyes .", "sentence_id": 6}
+{"abstract_id": "24792106", "label": "results", "text": "Mean ultrasound time , cumulative dissipated energy , and longitudinal and torsional ultrasound amplitudes in Group @ were @ seconds , @ , @ , and @ % , respectively , and these parameters in Group @ were @ seconds , @ , @ , and @ % , respectively .", "sentence_id": 7}
+{"abstract_id": "24792106", "label": "results", "text": "Cumulative dissipated energy and longitudinal and torsional amplitudes were found to be significantly lower in Group @ ( P = @ , P < @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24792106", "label": "results", "text": "Mean volumes of fluid used in Groups @ and @ were @ cc and @ cc , respectively ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24792106", "label": "conclusions", "text": "With the aid of a @ degree aperture angled tip , the OZil Intelligent Phaco torsional mode provided more effective lens removal than the combined torsional/longitudinal ultrasound mode , with a lower cumulative dissipated energy and volume of fluid used .", "sentence_id": 10}
+{"abstract_id": "24356749", "label": "objective", "text": "The aim of this study was to investigate whether genetic variance can influence the efficacy of glibenclamide in patients with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24356749", "label": "methods", "text": "A total of @ patients with type @ diabetes was enrolled from the Xiaoke Pills Clinical Trial , which is a double-blind , randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "24356749", "label": "methods", "text": "All the patients had been treated with glibenclamide for @ weeks , with strict drug dose adjustment and data collection .", "sentence_id": 2}
+{"abstract_id": "24356749", "label": "methods", "text": "Treatment failure was confirmed when patients reached the criteria for terminating their participation in the study ( fasting blood glucose level @ mmol/l on two consecutive tests @ weeks after reaching the pre-set maximal dose or maximal tolerated dose ) .", "sentence_id": 3}
+{"abstract_id": "24356749", "label": "methods", "text": "Using this cohort , we tested @ single-nucleotide polymorphisms ( SNPs ) in @ gene regions .", "sentence_id": 4}
+{"abstract_id": "24356749", "label": "methods", "text": "The genes in our study were involved in the metabolism of sulfonylureas , islet beta cell function , insulin resistance and beta cell growth and differentiation .", "sentence_id": 5}
+{"abstract_id": "24356749", "label": "methods", "text": "A logistic regression model was used to evaluate the relationship between genetic variants and treatment failure over a period of @ weeks .", "sentence_id": 6}
+{"abstract_id": "24356749", "label": "results", "text": "We found that no SNP reached the significance level of p < @ if Bonferroni correction was performed for multiple testing in the logistic regression model used in this pharmacogenetic study .", "sentence_id": 7}
+{"abstract_id": "24356749", "label": "results", "text": "Participants with the minor allele C of rs@ in CDKN@A/CDKN@B showed a significantly greater reduction in fasting blood glucose ( TT vs TC vs CC : @ % ( @-@ @ % ) vs @ % ( @-@ @ % ) vs @ % ( @-@ @ % ) , p = @ ) after the initial @ weeks of treatment independent of age , sex and BMI .", "sentence_id": 8}
+{"abstract_id": "24356749", "label": "results", "text": "There was a significant difference in beta cell function among carriers of different genotypes of rs@ .", "sentence_id": 9}
+{"abstract_id": "24356749", "label": "conclusions", "text": "Our study demonstrated that the CDKN@A/CDKN@B gene may be nominally associated with the efficacy of glibenclamide , and that CDKN@A/CDKN@B is associated with beta cell function .", "sentence_id": 10}
+{"abstract_id": "25346376", "label": "objective", "text": "The effect of the Pillar implant on mild sleep-disordered breathing ( SDB ) has been assessed in various studies .", "sentence_id": 0}
+{"abstract_id": "25346376", "label": "objective", "text": "However , most of these were conducted among a non-Asian population at a single institution .", "sentence_id": 1}
+{"abstract_id": "25346376", "label": "objective", "text": "Therefore , the aim of this study was to prospectively evaluate the efficacy of the Pillar implant in Asian patients with simple snoring and mild obstructive sleep apnea ( OSA ) at multiple centers .", "sentence_id": 2}
+{"abstract_id": "25346376", "label": "methods", "text": "Multicenter prospective clinical trials .", "sentence_id": 3}
+{"abstract_id": "25346376", "label": "methods", "text": "This study included consecutive subjects with simple snoring or mild OSA .", "sentence_id": 4}
+{"abstract_id": "25346376", "label": "methods", "text": "We examined subjective symptoms ( snoring intensity , frequency , witnessed apnea , and daytime sleepiness ) and objective snoring and respiratory parameters ( snoring duration -LSB- proportion of sleep while snoring louder than @ dB -RSB- , snoring loudness , apnea-hypopnea index , respiratory disturbance index , minimum arterial oxygen saturation , and oxygen desaturation index@ % ) at @ to @ months after surgery .", "sentence_id": 5}
+{"abstract_id": "25346376", "label": "methods", "text": "Adverse events were also investigated .", "sentence_id": 6}
+{"abstract_id": "25346376", "label": "results", "text": "Twenty-nine subjects with mild SDB completed the study .", "sentence_id": 7}
+{"abstract_id": "25346376", "label": "results", "text": "Whole group analysis found significant improvements in various subjective symptoms , but not in the objective snoring and respiratory parameters .", "sentence_id": 8}
+{"abstract_id": "25346376", "label": "results", "text": "A subgroup analysis of subjects with mild OSA ( n = @ ) found significant alleviation in various subjective symptoms , apnea-hypopnea index , respiratory disturbance index , and oxygen desaturation index@ % .", "sentence_id": 9}
+{"abstract_id": "25346376", "label": "results", "text": "No major complication related to surgery was observed , and most minor adverse effects were resolved without morbidity .", "sentence_id": 10}
+{"abstract_id": "25346376", "label": "conclusions", "text": "In selected Korean patients , the Pillar implant significantly improved not only subjective symptoms of mild SDB but also respiratory disturbances in mild OSA .", "sentence_id": 11}
+{"abstract_id": "25109754", "label": "objective", "text": "The study objective was to determine the impact of diabetes on radial artery and saphenous vein graft occlusion and clinical outcomes more than @ years after coronary artery bypass surgery in the multicenter Radial Artery Patency Study ( NCT@ ) .", "sentence_id": 0}
+{"abstract_id": "25109754", "label": "methods", "text": "A total of @ patients aged less than @ years with triple-vessel disease undergoing coronary bypass surgery participated in this study .", "sentence_id": 1}
+{"abstract_id": "25109754", "label": "methods", "text": "Angiographic follow-up occurred more than @ years after surgery with annual clinical follow-up .", "sentence_id": 2}
+{"abstract_id": "25109754", "label": "methods", "text": "The primary objective was to compare the proportion of complete graft occlusion between radial artery and saphenous vein grafts among diabetic and nondiabetic persons .", "sentence_id": 3}
+{"abstract_id": "25109754", "label": "methods", "text": "Additional objectives included determining predictors of complete graft occlusion and comparison of major adverse cardiac events defined by cardiac death , late myocardial infarction , and reintervention .", "sentence_id": 4}
+{"abstract_id": "25109754", "label": "results", "text": "There were @ of @ patients ( @ % ) with diabetes ; @ patients ( @/@ -LSB- @ % -RSB- diabetic ) underwent late angiography at mean of @ years after surgery .", "sentence_id": 5}
+{"abstract_id": "25109754", "label": "results", "text": "In diabetic patients , the proportion of complete graft occlusion was significantly lower in the radial grafts ( @/@ -LSB- @ % -RSB- ) than in the saphenous grafts ( @/@ -LSB- @ % -RSB- ) ( P = @ ) , and this was similar in nondiabetic patients ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25109754", "label": "results", "text": "Multivariate modeling showed that the use of the radial artery and high-grade target vessel stenosis were protective against late graft occlusion , whereas female gender , smoking history , and elevated creatinine were associated with an increased risk ; interaction between diabetic status and conduit type also was significant ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25109754", "label": "results", "text": "Major adverse cardiac events were higher in diabetic patients ( @/@ -LSB- @ % -RSB- vs @/@ -LSB- @ % -RSB- , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25109754", "label": "conclusions", "text": "The use of the radial artery should be strongly considered in diabetic patients undergoing coronary bypass surgery , especially with high-grade target vessel stenosis .", "sentence_id": 9}
+{"abstract_id": "24738516", "label": "background", "text": "Andropause and aging are associated with neuroendocrine dysfunctions .", "sentence_id": 0}
+{"abstract_id": "24738516", "label": "background", "text": "Growth hormone and testosterone play a significant role in several processes affecting adaptation and thereby also everyday functioning .", "sentence_id": 1}
+{"abstract_id": "24738516", "label": "background", "text": "The aim of this research project was to evaluate the effects of recombinant human growth hormone and testosterone enanthate injections on body mass and body composition , aerobic and anaerobic fitness and lipid profile in middle-aged men .", "sentence_id": 2}
+{"abstract_id": "24738516", "label": "methods", "text": "The research group was comprised of @ men aged @ - @ years .", "sentence_id": 3}
+{"abstract_id": "24738516", "label": "methods", "text": "Two series of laboratory analyses were performed .", "sentence_id": 4}
+{"abstract_id": "24738516", "label": "methods", "text": "Independent tests were carried out at baseline and after @ weeks of the experiment .", "sentence_id": 5}
+{"abstract_id": "24738516", "label": "methods", "text": "The data were analyzed using Statistica @ software .", "sentence_id": 6}
+{"abstract_id": "24738516", "label": "results", "text": "A two-way repeated measures ANOVA revealed a statistically significant effect of the intervention programme on fat-free mass ( ( @ ) = @ ) , total body fat ( ( @ ) = @ ) , total cholesterol ( ( @ ) = @ ) , high-density lipoprotein cholesterol ( ( @ ) = @ ) , low-density lipoprotein cholesterol ( ( @ ) = @ ) , triglyceride ( ( @ ) = @ ) , testosterone ( ( @ ) = @ ) , insulin-like growth factor @ ( ( @ ) = @ ) and growth hormone ( ( @ ) = @ ) .", "sentence_id": 7}
+{"abstract_id": "24738516", "label": "results", "text": "Furthermore , ANOVA revealed a statistically significant effect of the rhGH and T treatment on maximal oxygen uptake ( ( @ ) = @ ) , anaerobic threshold ( ( @ ) = @ ) and maximal work rate ( ( @ ) = @ ) .", "sentence_id": 8}
+{"abstract_id": "24738516", "label": "conclusions", "text": "It should be emphasized that the lipid profile was affected not only by rhGH + T replacement therapy , but also by the prescribed physical activity programme .", "sentence_id": 9}
+{"abstract_id": "24738516", "label": "conclusions", "text": "The strength and endurance fitness programme alone did not cause significant changes in body mass and composition , nor the anaerobic and aerobic capacity .", "sentence_id": 10}
+{"abstract_id": "24738516", "label": "conclusions", "text": "On the other hand , the rhGH = T treatment stimulated these changes significantly .", "sentence_id": 11}
+{"abstract_id": "25488897", "label": "objective", "text": "The objective of this study was to compare participation rates and clinical effectiveness of sedated esophagogastroduodenoscopy ( sEGD ) and unsedated transnasal endoscopy ( uTNE ) for esophageal assessment and Barrett 's esophagus ( BE ) screening in a population-based cohort .", "sentence_id": 0}
+{"abstract_id": "25488897", "label": "methods", "text": "This was a prospective , randomized , controlled trial in a community population .", "sentence_id": 1}
+{"abstract_id": "25488897", "label": "methods", "text": "Subjects @ years of age who previously completed validated gastrointestinal symptom questionnaires were randomized ( stratified by age , sex , and reflux symptoms ) to one of three screening techniques ( either sEGD or uTNE in a mobile research van ( muTNE ) or uTNE in a hospital outpatient endoscopy suite ( huTNE ) ) and invited to participate .", "sentence_id": 2}
+{"abstract_id": "25488897", "label": "results", "text": "Of the @ subjects , @ ( @ % ) agreed to participate ( muTNE n = @ , huTNE n = @ , and sEGD n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25488897", "label": "results", "text": "Participation rates were numerically higher in the unsedated arms of muTNE ( @ % ) and huTNE ( @ % ) compared with the sEGD arm ( @ % ) , but were not statistically different ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25488897", "label": "results", "text": "Complete evaluation of the esophagus was similar using muTNE ( @ % ) , huTNE ( @ % ) , and sEGD ( @ % ) techniques ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25488897", "label": "results", "text": "Mean recovery times ( min ) were longer for sEGD ( @ ) compared with muTNE ( @ ) and huTNE ( @ ) ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25488897", "label": "results", "text": "Approximately @ % of uTNE subjects were willing to undergo the procedure again in future .", "sentence_id": 7}
+{"abstract_id": "25488897", "label": "results", "text": "Respectively , @ % and @ % of participating subjects had esophagitis and BE .", "sentence_id": 8}
+{"abstract_id": "25488897", "label": "conclusions", "text": "Mobile van and clinic uTNE screening had comparable clinical effectiveness with similar participation rates and safety profile to sEGD .", "sentence_id": 9}
+{"abstract_id": "25488897", "label": "conclusions", "text": "Evaluation time with uTNE was significantly shorter .", "sentence_id": 10}
+{"abstract_id": "25488897", "label": "conclusions", "text": "Prevalence of BE and esophagitis in community subjects @ years of age was substantial .", "sentence_id": 11}
+{"abstract_id": "25488897", "label": "conclusions", "text": "Mobile and outpatient unsedated techniques may provide an effective alternative strategy to sEGD for esophageal assessment and BE screening .", "sentence_id": 12}
+{"abstract_id": "25945691", "label": "objective", "text": "Although medical intervention is the first option for treatment of nasal polyps , surgery is still a therapeutic option for symptomatic cases that do not respond or partially respond to medical intervention .", "sentence_id": 0}
+{"abstract_id": "25945691", "label": "objective", "text": "However , there is a need for high-level evidence for the preoperative use of steroids in nasal polyposis surgery .", "sentence_id": 1}
+{"abstract_id": "25945691", "label": "objective", "text": "We aimed to assess the perioperative effect of preoperative use of oral prednisolone for advanced-stage diffuse nasal polyposis .", "sentence_id": 2}
+{"abstract_id": "25945691", "label": "methods", "text": "Prospective , double-blind , randomized , placebo-controlled study .", "sentence_id": 3}
+{"abstract_id": "25945691", "label": "methods", "text": "A visual analog scale ( VAS ) was evaluated for smell , nasal discharge , nasal obstruction , facial pressure , headache , butanol smell threshold , and peak nasal inspiratory flow ( PNIF ) before and after the use of study drug .", "sentence_id": 4}
+{"abstract_id": "25945691", "label": "methods", "text": "Perioperative bleeding volume , visibility of operative field , operative time , hospital stay , and complication rate were also evaluated .", "sentence_id": 5}
+{"abstract_id": "25945691", "label": "results", "text": "The improvement in the corticosteroid group ( CG ) in the VAS scores , butanol thresholds , and PNIF values showed statistically significant differences compared to the placebo group ( PG ) ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25945691", "label": "results", "text": "The perioperative bleeding volume , visibility score , operative time , and hospital stay for CG/PG were @ mL/@ mL , @ / @ , @ min/@ @ min , and @ day/@ @ day , respectively ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25945691", "label": "results", "text": "The difference between the complication rates for the two groups did not show any statistically significant difference ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25945691", "label": "conclusions", "text": "Preoperative administration of systemic corticosteroids improves the perioperative visibility by reducing blood loss and shortens the operation time .", "sentence_id": 9}
+{"abstract_id": "25945691", "label": "conclusions", "text": "We recommend the use of preoperative corticosteroid for the safety of the patients .", "sentence_id": 10}
+{"abstract_id": "25945691", "label": "conclusions", "text": "The optimum dose and duration have not been established and require further studies .", "sentence_id": 11}
+{"abstract_id": "24470436", "label": "objective", "text": "Observational studies suggest that hydroxychloroquine ( HCQ ) may reduce the risk of developing diabetes mellitus in patients with rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "24470436", "label": "objective", "text": "We examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA .", "sentence_id": 1}
+{"abstract_id": "24470436", "label": "methods", "text": "Twenty-three RA subjects not currently using HCQ completed a @-week , double-blind crossover study .", "sentence_id": 2}
+{"abstract_id": "24470436", "label": "methods", "text": "Subjects were randomly allocated to receive HCQ ( @ mg/kg/day ) or placebo for the first @ weeks , followed by crossover to the other arm for the final @ weeks .", "sentence_id": 3}
+{"abstract_id": "24470436", "label": "methods", "text": "Subjects underwent oral glucose tolerance testing and fasting lipid measurements at baseline , @ weeks , and @ weeks .", "sentence_id": 4}
+{"abstract_id": "24470436", "label": "methods", "text": "The change SD from baseline in insulin sensitivity index ( ISI ) , homeostatic model assessment for insulin resistance ( HOMA-IR ) , and lipid parameters were compared between placebo and HCQ using linear regression .", "sentence_id": 5}
+{"abstract_id": "24470436", "label": "results", "text": "The mean patient age was @ years , with @ % women , and the median body mass index was @ kg/m@ .", "sentence_id": 6}
+{"abstract_id": "24470436", "label": "results", "text": "After @ weeks of HCQ , the mean SD ISI increase was @ @ compared with a small increase during placebo of @ @ ( adjusted P = @ ) , and the mean SD HOMA-IR decrease was @ @ during HCQ versus a decrease of @ @ during placebo ( adjusted P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24470436", "label": "results", "text": "Small decreases in total cholesterol ( @ mg/dl ) and low-density lipoprotein ( LDL ) cholesterol ( @ mg/dl ) were observed during the HCQ treatment periods ( both adjusted P < @ compared to placebo ) .", "sentence_id": 8}
+{"abstract_id": "24470436", "label": "conclusions", "text": "HCQ use for @ weeks in patients without diabetes mellitus with stable RA produced no significant change in insulin resistance .", "sentence_id": 9}
+{"abstract_id": "24470436", "label": "conclusions", "text": "We observed small and statistically significant improvements in total and LDL cholesterol during HCQ treatment .", "sentence_id": 10}
+{"abstract_id": "24428951", "label": "background", "text": "Breastfeeding has countless benefits to mothers , children and community at large , especially in developing countries .", "sentence_id": 0}
+{"abstract_id": "24428951", "label": "background", "text": "Studies from Lebanon report disappointingly low breastfeeding exclusivity and continuation rates .", "sentence_id": 1}
+{"abstract_id": "24428951", "label": "background", "text": "Evidence reveals that antenatal breastfeeding education , professional lactation support , and peer lay support are individually effective at increasing breastfeeding duration and exclusivity , particularly in low-income settings .", "sentence_id": 2}
+{"abstract_id": "24428951", "label": "background", "text": "Given the complex nature of the breastfeeding ecosystem and its barriers in Lebanon , we hypothesize that a complex breastfeeding support intervention , which is centered on the three components mentioned above , would significantly increase breastfeeding rates .", "sentence_id": 3}
+{"abstract_id": "24428951", "label": "methods", "text": "A multi-center randomized controlled trial .", "sentence_id": 4}
+{"abstract_id": "24428951", "label": "methods", "text": "@ healthy pregnant women in their first trimester will be randomized to control or intervention group .", "sentence_id": 5}
+{"abstract_id": "24428951", "label": "methods", "text": "A `` prenatal/postnatal '' professional and peer breastfeeding support package continuing till @ months postpartum , guided by the Social Network and Social Support Theory .", "sentence_id": 6}
+{"abstract_id": "24428951", "label": "methods", "text": "Control group will receive standard prenatal and postnatal care .", "sentence_id": 7}
+{"abstract_id": "24428951", "label": "methods", "text": "Mothers will be followed up from early pregnancy till five years after delivery .", "sentence_id": 8}
+{"abstract_id": "24428951", "label": "methods", "text": "Total and exclusive breastfeeding rates , quality of life at @ , @ and @ months postpartum , maternal breastfeeding knowledge and attitudes at @ months postpartum , maternal exclusive breastfeeding rates of future infants up to five years from baseline , cost-benefit and cost-effectiveness analyses of the intervention .", "sentence_id": 9}
+{"abstract_id": "24428951", "label": "methods", "text": "Descriptive and regression analysis will be conducted under the intention to treat basis using the most recent version of SPSS .", "sentence_id": 10}
+{"abstract_id": "24428951", "label": "conclusions", "text": "Exclusive breastfeeding is a cost-effective public health measure that has a significant impact on infant morbidity and mortality .", "sentence_id": 11}
+{"abstract_id": "24428951", "label": "conclusions", "text": "In a country with limited healthcare resources like Lebanon , developing an effective breastfeeding promotion and support intervention that is easily replicated across various settings becomes a priority .", "sentence_id": 12}
+{"abstract_id": "24428951", "label": "conclusions", "text": "If positive , the results of this study would provide a generalizable model to bolster breastfeeding promotion efforts and contribute to improved child health in Lebanon and the Middle East and North Africa ( MENA ) region .", "sentence_id": 13}
+{"abstract_id": "24935020", "label": "objective", "text": "Beta-blockers ( BBs ) improve outcomes in heart failure .", "sentence_id": 0}
+{"abstract_id": "24935020", "label": "objective", "text": "Results from the Cardiac Insufficiency Bisoprolol Study in Elderly ( CIBIS-ELD ) trial previously demonstrated the feasibility of heart rate , not maximum dose , as a treatment goal .", "sentence_id": 1}
+{"abstract_id": "24935020", "label": "objective", "text": "In this pre-specified analysis , we investigated the prognostic value of achieved heart rate after BB optimization on long-term mortality .", "sentence_id": 2}
+{"abstract_id": "24935020", "label": "results", "text": "Elderly heart failure patients from the CIBIS-ELD trial were invited to participate in a follow-up examination @ years after the initial @-week BB up-titration period .", "sentence_id": 3}
+{"abstract_id": "24935020", "label": "results", "text": "The relationship between all-cause mortality , BB dose , and heart rate after titration and potentially confounding clinical variables was analysed by multivariable Cox regression .", "sentence_id": 4}
+{"abstract_id": "24935020", "label": "results", "text": "In total , @ patients ( @ % women ; mean age @ @ years ) were included .", "sentence_id": 5}
+{"abstract_id": "24935020", "label": "results", "text": "During a mean follow-up period of @ @ months , @ patients ( @ % ) died , thus accumulating @ patient-years at risk .", "sentence_id": 6}
+{"abstract_id": "24935020", "label": "results", "text": "There was no significant difference in baseline heart rate for survivors and non-survivors ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24935020", "label": "results", "text": "In models adjusting for age , sex , BB pre-treatment , ventricular function , heart rate , and NYHA class at baseline , a heart rate increase by @ b.p.m. following up-titration was associated with a subsequent mortality hazard ratio of @ ( @ % confidence interval @-@ @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24935020", "label": "results", "text": "The heart rate range with the lowest mortality and the fewest treatment-related adverse events was @-@ b.p.m.", "sentence_id": 9}
+{"abstract_id": "24935020", "label": "results", "text": "The achieved BB dose was not associated with mortality risk .", "sentence_id": 10}
+{"abstract_id": "24935020", "label": "conclusions", "text": "The heart rate after up-titration , but not BB dose , predicted all-cause mortality risk in elderly patients with chronic heart failure .", "sentence_id": 11}
+{"abstract_id": "24935020", "label": "conclusions", "text": "These patients should be titrated to resting heart rates between @ and @ b.p.m.", "sentence_id": 12}
+{"abstract_id": "24518763", "label": "objective", "text": "Regional analgesic techniques are commonly used in pediatric urology .", "sentence_id": 0}
+{"abstract_id": "24518763", "label": "objective", "text": "Ultrasound guided transversus abdominis plane block has recently gained popularity .", "sentence_id": 1}
+{"abstract_id": "24518763", "label": "objective", "text": "However , there is a paucity of information supporting a benefit over regional field infiltration .", "sentence_id": 2}
+{"abstract_id": "24518763", "label": "objective", "text": "We present a parallel group , randomized , controlled trial evaluating ultrasound guided transversus abdominis plane block superiority over surgeon delivered regional field infiltration for children undergoing open pyeloplasty at a tertiary referral center .", "sentence_id": 3}
+{"abstract_id": "24518763", "label": "methods", "text": "Following ethics board approval and registration , children @ to @ years old were recruited and randomized to undergo perioperative transversus abdominis plane block or regional field infiltration for early post-pyeloplasty pain control .", "sentence_id": 4}
+{"abstract_id": "24518763", "label": "methods", "text": "General anesthetic delivery , surgical technique and postoperative analgesics were standardized .", "sentence_id": 5}
+{"abstract_id": "24518763", "label": "methods", "text": "A blinded assessor regularly captured pain scores in the recovery room using the FLACC ( Face , Legs , Activity , Cry , Consolability ) scale .", "sentence_id": 6}
+{"abstract_id": "24518763", "label": "methods", "text": "The primary outcome was the need for rescue morphine administration based on a FLACC score of @ or higher .", "sentence_id": 7}
+{"abstract_id": "24518763", "label": "results", "text": "Two pediatric urologists performed @ pyeloplasties during a @-year period , enrolling @ children ( @ in each group , balanced for age and weight ) .", "sentence_id": 8}
+{"abstract_id": "24518763", "label": "results", "text": "There were statistically significant differences in the number of children requiring rescue morphine administration ( @ of @ receiving transversus abdominis plane block and @ of @ receiving regional field infiltration , p = @ ) , mean SD total morphine consumption ( @ @ vs @ @ mg/kg , p = @ ) and mean SD pain scores ( @ @ vs @ @ , p = @ ) in the recovery room , in favor of surgeon administered regional field infiltration .", "sentence_id": 9}
+{"abstract_id": "24518763", "label": "results", "text": "No local anesthetic specific adverse events were noted .", "sentence_id": 10}
+{"abstract_id": "24518763", "label": "conclusions", "text": "Ultrasound guided transversus abdominis plane block is not superior to regional field infiltration with bupivacaine as a strategy to minimize early opioid requirements following open pyeloplasty in children .", "sentence_id": 11}
+{"abstract_id": "24518763", "label": "conclusions", "text": "Instead , our data suggest that surgeon delivered regional field infiltration provides better pain control .", "sentence_id": 12}
+{"abstract_id": "24305430", "label": "background", "text": "The addition of hydrophobically modified polymers ( HMPs ) to cleansers that contain surfactants can create polymer-surfactant complexes that are less irritating to the skin than commercially available mild cleansers .", "sentence_id": 0}
+{"abstract_id": "24305430", "label": "background", "text": "Our objective was to compare the tolerability and efficacy of a test foaming liquid facial cleanser containing HMPs with a commercial liquid nonfoaming facial cleanser in women with sensitive skin .", "sentence_id": 1}
+{"abstract_id": "24305430", "label": "methods", "text": "In this randomized , prospective , double-blind , comparative study , women ( n = @ per group ) with mild-to-moderate atopic dermatitis ( AD ) , eczema , acne , or rosacea used a test gentle foaming liquid facial cleanser containing HMPs or a commercial gentle liquid nonfoaming facial cleanser daily for @weeks .", "sentence_id": 2}
+{"abstract_id": "24305430", "label": "methods", "text": "Investigators assessed irritation and skin condition .", "sentence_id": 3}
+{"abstract_id": "24305430", "label": "methods", "text": "Study subjects also assessed their skin properties and the performance of each cleanser .", "sentence_id": 4}
+{"abstract_id": "24305430", "label": "results", "text": "Clinicians as well as study subjects consistently rated the test cleanser as effective or slightly more effective at improving symptoms than the commercial cleanser , although no significant differences between groups were observed .", "sentence_id": 5}
+{"abstract_id": "24305430", "label": "results", "text": "At weeks @ and @ , respectively , more users of the commercial cleanser reported irritation ( @ % and @ % ) than users of the test cleanser ( @ % and @ % ) .", "sentence_id": 6}
+{"abstract_id": "24305430", "label": "results", "text": "In addition , subject self-assessments of skin condition and cleansing properties were slightly more improved with the test cleanser than with the commercial cleanser .", "sentence_id": 7}
+{"abstract_id": "24305430", "label": "conclusions", "text": "Both the test foaming cleanser containing HMPs and the commercial nonfoaming cleanser were effective and well accepted by most women in the study .", "sentence_id": 8}
+{"abstract_id": "24305430", "label": "conclusions", "text": "Improvements were observed by both clinicians and subjects in the group using the test cleanser containing HMPs in all evaluated skin categories .", "sentence_id": 9}
+{"abstract_id": "24684105", "label": "objective", "text": "To determine the safety and effectiveness of electroacupuncture ( EA ) intervention combined with general anesthesia ( GA ) for craniocerebral tumor-removal surgery involving cerebral eloquent areas .", "sentence_id": 0}
+{"abstract_id": "24684105", "label": "methods", "text": "A total of @ patients with cerebral tumors ( durosarcoma , neurogliocytoma , metastatic tumor ) involving the cerebral eloquent areas were recruited in the present summary .", "sentence_id": 1}
+{"abstract_id": "24684105", "label": "methods", "text": "They were equally divided into general anesthesia ( GA ) group and EA + GA group .", "sentence_id": 2}
+{"abstract_id": "24684105", "label": "methods", "text": "Patients of the EA + GA group were treated with EA stimulation ( @ Hz/@ Hz ) of the bilateral Fengchi ( GB @ ) , Shuaigu ( GB @ ) and acupuncture stimulation of Quanliao ( SI @ ) , Zulinqi ( GB @ ) and Taichong ( LR @ ) , and not given intubation during surgery .", "sentence_id": 3}
+{"abstract_id": "24684105", "label": "methods", "text": "Patients of the GA group were treated with intravenous administration of Propofol , Fentanyl , Midazolam , Isopropanol , etc. .", "sentence_id": 4}
+{"abstract_id": "24684105", "label": "methods", "text": "In addition , all the patients were given with controlled hypotension by intravenous injection of Propofol and Fentanyl .", "sentence_id": 5}
+{"abstract_id": "24684105", "label": "methods", "text": "Dosages of Propofol and Sulfentanyl used were recorded .", "sentence_id": 6}
+{"abstract_id": "24684105", "label": "methods", "text": "Karnofsky performance status scale was used to assess the patient 's general well-being and activities of daily life .", "sentence_id": 7}
+{"abstract_id": "24684105", "label": "results", "text": "The craniocerebral tumor-removal surgery was successful in all the @ patients .", "sentence_id": 8}
+{"abstract_id": "24684105", "label": "results", "text": "Compared with the GA group , the dosages of Sulfentanyl and Propofol of the EA + GA group were significantly lower ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24684105", "label": "results", "text": "No significant difference was found between the GA and EA + GA groups in Karnofsky performance scores ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "24684105", "label": "results", "text": "Patients of the EA+GA group experienced successful tumour-removal surgery without trachea cannula , were awake and could make a good cooperation with the operator during surgery .", "sentence_id": 11}
+{"abstract_id": "24684105", "label": "results", "text": "They had no aggravation of neurofunctional disturbance following the operation .", "sentence_id": 12}
+{"abstract_id": "24684105", "label": "conclusions", "text": "EA combined with general anesthesia is safe and effective for patients with craniocerebral tumor-removal operations involving cerebral eloquent areas .", "sentence_id": 13}
+{"abstract_id": "25139724", "label": "objective", "text": "To determine if intrauterine administration of @ cc of @ % lidocaine in addition to paracervical block reduces pain during laminaria insertion , when compared with paracervical block and saline placebo .", "sentence_id": 0}
+{"abstract_id": "25139724", "label": "methods", "text": "This was a randomized , double blind placebo-controlled trial .", "sentence_id": 1}
+{"abstract_id": "25139724", "label": "methods", "text": "Women presenting for abortion by dilation and evacuation ( D&E ) at @-@ weeks gestational age were randomized to receive an intrauterine instillation of either @ mL of @ % lidocaine or @ mL of normal saline , in addition to standard paracervical block with @ cc of @ % bupivacaine .", "sentence_id": 2}
+{"abstract_id": "25139724", "label": "methods", "text": "Our primary outcome was self-reported pain scores on a @mm Visual Analogue Scale ( VAS ) immediately following laminaria insertion .", "sentence_id": 3}
+{"abstract_id": "25139724", "label": "methods", "text": "Secondary outcome was self-reported VAS pain score indicating the maximum level of pain experienced during the @-@-h interval between laminaria insertion and D&E procedure .", "sentence_id": 4}
+{"abstract_id": "25139724", "label": "results", "text": "Seventy-two women were enrolled , and data for @ women were analyzed , only two of whom were more than @ weeks on gestation .", "sentence_id": 5}
+{"abstract_id": "25139724", "label": "results", "text": "The range of pain scores at both time points was large ( @-@ mm at laminaria insertion ; @-@mm in laminaria-D & E interval ) .", "sentence_id": 6}
+{"abstract_id": "25139724", "label": "results", "text": "Mean pain scores were not different between treatment groups at laminaria insertion , ( @ vs. @ , p = @ ) or in the laminaria - D&E interval ( @ vs. @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25139724", "label": "conclusions", "text": "Intrauterine administration of @ cc of @ % lidocaine in addition to paracervical block did not reduce pain with laminaria insertion when compared to paracervical block with saline placebo .", "sentence_id": 8}
+{"abstract_id": "25139724", "label": "conclusions", "text": "Intrauterine lidocaine combined with paracervical block does not improve pain control at laminaria insertion when compared with paracervical block and saline placebo .", "sentence_id": 9}
+{"abstract_id": "25139724", "label": "conclusions", "text": "Wide variation in pain scores and persistent pain after laminaria insertion suggests patient would benefit from more effective methods of pain control at laminaria insertion and during the post-laminaria interval .", "sentence_id": 10}
+{"abstract_id": "25256368", "label": "background", "text": "Our aim was to determine if a surgeon 's behaviors can encourage or discourage trainees from speaking up when they witness a surgical mistake .", "sentence_id": 0}
+{"abstract_id": "25256368", "label": "methods", "text": "A randomized clinical trial in which medical students ( n = @ ) were randomly assigned to an `` encouraged '' ( n = @ ) or `` discouraged '' ( n = @ ) group .", "sentence_id": 1}
+{"abstract_id": "25256368", "label": "methods", "text": "Participants underwent personality tests to assess decision-making styles , and were then trained on basic tasks ( `` burn '' then `` cut '' ) on a laparoscopic surgery simulator .", "sentence_id": 2}
+{"abstract_id": "25256368", "label": "methods", "text": "After randomization , students assisted at a simulated laparoscopic salpingectomy .", "sentence_id": 3}
+{"abstract_id": "25256368", "label": "methods", "text": "The senior surgeon used either an `` encourage '' script ( eg , `` Your opinion is important . '' )", "sentence_id": 4}
+{"abstract_id": "25256368", "label": "methods", "text": "or a `` discourage '' script ( eg , `` Do what I say .", "sentence_id": 5}
+{"abstract_id": "25256368", "label": "methods", "text": "Save questions for next time . '' )", "sentence_id": 6}
+{"abstract_id": "25256368", "label": "methods", "text": "Otherwise , the surgery was conducted identically .", "sentence_id": 7}
+{"abstract_id": "25256368", "label": "methods", "text": "Subsequently , a surgical mistake was made by the senior surgeon when he instructed students to cut without burning .", "sentence_id": 8}
+{"abstract_id": "25256368", "label": "methods", "text": "Students were considered to have spoken up if they questioned the instruction and did not cut .", "sentence_id": 9}
+{"abstract_id": "25256368", "label": "methods", "text": "Potential personality bias was assessed with two validated personality tests before simulation .", "sentence_id": 10}
+{"abstract_id": "25256368", "label": "methods", "text": "Data were processed with Mann-Whitney and Fisher exact tests .", "sentence_id": 11}
+{"abstract_id": "25256368", "label": "results", "text": "The students in the encouraged group were significantly more likely to speak up ( @ of @ -LSB- @ % -RSB- vs @ of @ -LSB- @ % -RSB- ; p < @ ) .", "sentence_id": 12}
+{"abstract_id": "25256368", "label": "results", "text": "There was no statistically significant difference between the two groups in personality traits , student training level ( p = @ ) , or sex ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25256368", "label": "conclusions", "text": "A discouraging environment decreases the frequency with which trainees speak up when witnessing a surgical error .", "sentence_id": 14}
+{"abstract_id": "25256368", "label": "conclusions", "text": "The senior surgeon plays an important role in improving intraoperative communication between junior and senior clinicians and can enhance patient safety .", "sentence_id": 15}
+{"abstract_id": "24913003", "label": "background", "text": "Despite growing emphasis on transitional care to reduce costs and improve quality , few studies have examined transitional care improvements in socioeconomically disadvantaged adults .", "sentence_id": 0}
+{"abstract_id": "24913003", "label": "background", "text": "It is important to consider these patients separately as many are high-utilizers , have different needs , and may have different responses to interventions .", "sentence_id": 1}
+{"abstract_id": "24913003", "label": "objective", "text": "To evaluate the impact of a multicomponent transitional care improvement program on @-day readmissions , emergency department ( ED ) use , transitional care quality , and mortality .", "sentence_id": 2}
+{"abstract_id": "24913003", "label": "methods", "text": "Clustered randomized controlled trial conducted at a single urban academic medical center in Portland , Oregon .", "sentence_id": 3}
+{"abstract_id": "24913003", "label": "methods", "text": "Three hundred eighty-two hospitalized low-income adults admitted to general medicine or cardiology who were uninsured or had public insurance .", "sentence_id": 4}
+{"abstract_id": "24913003", "label": "methods", "text": "Multicomponent intervention including ( @ ) transitional nurse coaching and education , including home visits for highest risk patients ; ( @ ) pharmacy care , including provision of @ days of medications after discharge for those without prescription drug coverage ; ( @ ) post-hospital primary care linkages ; ( @ ) systems integration and continuous quality improvement .", "sentence_id": 5}
+{"abstract_id": "24913003", "label": "methods", "text": "Primary outcomes included @-day inpatient readmission and ED use .", "sentence_id": 6}
+{"abstract_id": "24913003", "label": "methods", "text": "Readmission data were obtained using state-wide administrative data for all participants ( insured and uninsured ) .", "sentence_id": 7}
+{"abstract_id": "24913003", "label": "methods", "text": "Secondary outcomes included quality ( @-item Care Transitions Measure ) and mortality .", "sentence_id": 8}
+{"abstract_id": "24913003", "label": "methods", "text": "Research staff administering questionnaires and assessing outcomes were blinded .", "sentence_id": 9}
+{"abstract_id": "24913003", "label": "results", "text": "There was no significant difference in @-day readmission between C-TraIn ( @/@ , @ % ) and control patients ( @/@ , @ % ) , p = @ , or in ED visits between C-TraIn ( @/@ , @ % ) and control ( @/@ , @ % ) , p = @ .", "sentence_id": 10}
+{"abstract_id": "24913003", "label": "results", "text": "C-TraIn was associated with improved transitional care quality ; @ % ( @/@ ) of C-TraIn patients reported a high quality transition compared to @ % ( @/@ ) control patients , odds ratio @ ( @ % CI @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24913003", "label": "results", "text": "Zero C-TraIn patients died in the @-day post-discharge period compared with five in the control group ( unadjusted p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24913003", "label": "conclusions", "text": "C-TraIn did not reduce @-day inpatient readmissions or ED use ; however , it improved transitional care quality .", "sentence_id": 13}
+{"abstract_id": "24786469", "label": "objective", "text": "To compare the effect of heated , humidified , high-flow nasal cannula ( HHHFNC ) and nasal continuous positive airways pressure ( NCPAP ) on lung function and mechanics in preterm infants with respiratory distress syndrome ( RDS ) at the same level of retropharyngeal pressure ( Prp ) .", "sentence_id": 0}
+{"abstract_id": "24786469", "label": "methods", "text": "Randomised crossover trial .", "sentence_id": 1}
+{"abstract_id": "24786469", "label": "methods", "text": "Neonatal intensive care unit , Ospedale Maggiore Policlinico , Milan , Italy .", "sentence_id": 2}
+{"abstract_id": "24786469", "label": "methods", "text": "@ preterm infants ( gestational age : @ wks ) with mild-moderate RDS requiring non-invasive respiratory support within @ h after birth .", "sentence_id": 3}
+{"abstract_id": "24786469", "label": "methods", "text": "Infants were exposed to a randomised sequence of NCPAP and HHHFNC at different settings ( @ , @ and @ cmHO for NCPAP and @ , @ , @ L/min for HHHFNC ) to enable comparison at the same level of Prp .", "sentence_id": 4}
+{"abstract_id": "24786469", "label": "methods", "text": "Tidal volume by respiratory inductance plethysmography , pleural pressure estimated by oesophageal pressure , and gas exchange were evaluated at each setting and used to compute breathing pattern parameters , lung mechanics and work of breathing ( WOB ) .", "sentence_id": 5}
+{"abstract_id": "24786469", "label": "results", "text": "A poor linear regression between flow and Prp was found during HHHFNC ( Prp = @ +@ * flow ; r = @ ) .", "sentence_id": 6}
+{"abstract_id": "24786469", "label": "results", "text": "Only in @ out of @ infants it was possible to compare HHHFNC and NCPAP at a Prp of @ and @ cmHO .", "sentence_id": 7}
+{"abstract_id": "24786469", "label": "results", "text": "No statistically significant differences were found in breathing pattern , gas exchange , lung mechanics and total WOB .", "sentence_id": 8}
+{"abstract_id": "24786469", "label": "results", "text": "Resistive WOB in the upper airways was slightly but significantly higher during HHHFNC ( @ ( @ ; @ ) vs @ ( @ ; @ ) cmHO median ( IQR ) ) .", "sentence_id": 9}
+{"abstract_id": "24786469", "label": "conclusions", "text": "Despite differing mechanisms for generating positive airway pressure , when compared at the same Prp , NCPAP and HHHFNC provide similar effects on all the outcomes explored .", "sentence_id": 10}
+{"abstract_id": "25619520", "label": "background", "text": "Recurrent airway obstruction ( RAO ) , an asthma-like disease , is @ of the most common allergic diseases in horses in the northern hemisphere .", "sentence_id": 0}
+{"abstract_id": "25619520", "label": "background", "text": "Hypersensitivity reactions to environmental antigens cause an allergic inflammatory response in the equine airways .", "sentence_id": 1}
+{"abstract_id": "25619520", "label": "background", "text": "Cytosine-phosphate-guanosine-oligodeoxynucleotides ( CpG-ODN ) are known to direct the immune system toward a Th@-pathway , and away from the pro-allergic Th@-line ( Th@/Th@-shift ) .", "sentence_id": 2}
+{"abstract_id": "25619520", "label": "background", "text": "Gelatin nanoparticles ( GNPs ) are biocompatible and biodegradable immunological inert drug delivery systems that protect CpG-ODN against nuclease degeneration .", "sentence_id": 3}
+{"abstract_id": "25619520", "label": "background", "text": "Preliminary studies on the inhalation of GNP-bound CpG-ODN in RAO-affected horses have shown promising results .", "sentence_id": 4}
+{"abstract_id": "25619520", "label": "objective", "text": "The aim of this study was to evaluate the clinical and immunological effects of GNP-bound CpG-ODN in a double-blinded , placebo-controlled , prospective , randomized clinical trial and to verify a sustained effect post-treatment .", "sentence_id": 5}
+{"abstract_id": "25619520", "label": "methods", "text": "Twenty-four RAO-affected horses received @ inhalation every @ days for @ consecutive administrations .", "sentence_id": 6}
+{"abstract_id": "25619520", "label": "methods", "text": "Horses were examined for clinical , endoscopic , cytological , and blood biochemical variables before the inhalation regimen ( I ) , immediately afterwards ( II ) , and @ weeks post-treatment ( III ) .", "sentence_id": 7}
+{"abstract_id": "25619520", "label": "results", "text": "At time points I and II , administration of treatment rather than placebo corresponded to a statistically significant decrease in respiratory effort , nasal discharge , tracheal secretion , and viscosity , AaDO@ and neutrophil percentage , and an increase in arterial oxygen pressure .", "sentence_id": 8}
+{"abstract_id": "25619520", "label": "conclusions", "text": "Administration of a GNP-bound CpG-ODN formulation caused a potent and persistent effect on allergic and inflammatory-induced clinical variables in RAO-affected horses .", "sentence_id": 9}
+{"abstract_id": "25619520", "label": "conclusions", "text": "This treatment , therefore , provides an innovative , promising , and well-tolerated strategy beyond conventional symptomatic long-term therapy and could serve as a model for asthma treatment in humans .", "sentence_id": 10}
+{"abstract_id": "26057285", "label": "objective", "text": "Some patients with lower leg amputations may be candidates for motorized prosthetic limbs .", "sentence_id": 0}
+{"abstract_id": "26057285", "label": "objective", "text": "Optimal control of such devices requires accurate classification of the patient 's ambulation mode ( eg , on level ground or ascending stairs ) and natural transitions between different ambulation modes .", "sentence_id": 1}
+{"abstract_id": "26057285", "label": "objective", "text": "To determine the effect of including electromyographic ( EMG ) data and historical information from prior gait strides in a real-time control system for a powered prosthetic leg capable of level-ground walking , stair ascent and descent , ramp ascent and descent , and natural transitions between these ambulation modes .", "sentence_id": 2}
+{"abstract_id": "26057285", "label": "methods", "text": "Blinded , randomized crossover clinical trial conducted between August @ and November @ in a research laboratory at the Rehabilitation Institute of Chicago .", "sentence_id": 3}
+{"abstract_id": "26057285", "label": "methods", "text": "Participants were @ patients with unilateral above-knee ( n = @ ) or knee-disarticulation ( n = @ ) amputations .", "sentence_id": 4}
+{"abstract_id": "26057285", "label": "methods", "text": "All patients were capable of ambulation within their home and community using a passive prosthesis ( ie , one that does not provide external power ) .", "sentence_id": 5}
+{"abstract_id": "26057285", "label": "methods", "text": "Electrodes were placed over @ residual limb muscles and EMG signals were recorded as patients ambulated and completed @ circuit trials involving level-ground walking , ramp ascent and descent , and stair ascent and descent .", "sentence_id": 6}
+{"abstract_id": "26057285", "label": "methods", "text": "Data were acquired simultaneously from @ mechanical sensors embedded on the prosthesis .", "sentence_id": 7}
+{"abstract_id": "26057285", "label": "methods", "text": "Two real-time pattern recognition algorithms , using either ( @ ) mechanical sensor data alone or ( @ ) mechanical sensor data in combination with EMG data and historical information from earlier in the gait cycle , were evaluated .", "sentence_id": 8}
+{"abstract_id": "26057285", "label": "methods", "text": "The order in which patients used each configuration was randomized ( @:@ blocked randomization ) and double-blinded so patients and experimenters did not know which control configuration was being used .", "sentence_id": 9}
+{"abstract_id": "26057285", "label": "methods", "text": "The main outcome of the study was classification error for each real-time control system .", "sentence_id": 10}
+{"abstract_id": "26057285", "label": "methods", "text": "Classification error is defined as the percentage of steps incorrectly predicted by the control system .", "sentence_id": 11}
+{"abstract_id": "26057285", "label": "results", "text": "Including EMG signals and historical information in the real-time control system resulted in significantly lower classification error ( mean , @ % -LSB- @ % CI , @ % -@ % -RSB- ) across a mean of @ steps ( range , @-@ steps ) compared with using mechanical sensor data only ( mean , @ % -LSB- @ % CI , @ % -@ % -RSB- ) across a mean of @ steps ( range , @-@ steps ) , with a mean difference between groups of @ % ( @ % CI , @ % -@ % -RSB- ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "26057285", "label": "conclusions", "text": "In this study of @ patients with lower limb amputations , inclusion of EMG signals and temporal gait information reduced classification error across ambulation modes and during transitions between ambulation modes .", "sentence_id": 13}
+{"abstract_id": "26057285", "label": "conclusions", "text": "These preliminary findings , if confirmed , have the potential to improve the control of powered leg prostheses .", "sentence_id": 14}
+{"abstract_id": "25127697", "label": "objective", "text": "To measure choroidal thickness on spectral-domain optical coherence tomography ( SD OCT ) images using automated algorithms and to correlate choroidal pathology with retinal changes attributable to diabetic macular edema ( DME ) .", "sentence_id": 0}
+{"abstract_id": "25127697", "label": "methods", "text": "Post hoc analysis of multicenter clinical trial baseline data .", "sentence_id": 1}
+{"abstract_id": "25127697", "label": "methods", "text": "SD OCT raster scans/fluorescein angiograms were obtained from @ treatment-nave eyes of @ patients with clinically significant DME and from @ controls .", "sentence_id": 2}
+{"abstract_id": "25127697", "label": "methods", "text": "Three-dimensional ( @D ) SD OCT images were evaluated by a certified independent reading center analyzing retinal changes associated with diabetic retinopathy .", "sentence_id": 3}
+{"abstract_id": "25127697", "label": "methods", "text": "Choroidal thicknesses were analyzed using a fully automated algorithm .", "sentence_id": 4}
+{"abstract_id": "25127697", "label": "methods", "text": "Angiograms were assessed manually .", "sentence_id": 5}
+{"abstract_id": "25127697", "label": "methods", "text": "Multiple endpoint correction according to Bonferroni-Holm was applied .", "sentence_id": 6}
+{"abstract_id": "25127697", "label": "methods", "text": "Main outcome measures were average retinal/choroidal thickness on fovea-centered or peak of edema ( thickest point of edema ) - centered Early Treatment Diabetic Retinopathy Study grid , maximum area of leakage , and the correlation between retinal and choroidal thicknesses .", "sentence_id": 7}
+{"abstract_id": "25127697", "label": "results", "text": "Total choroidal thickness is significantly reduced in DME ( @ @ m ; P = @ ) and nonedematous fellow eyes ( @ @ m ; P = @ ) of patients compared with healthy control eyes ( @ @ m ) .", "sentence_id": 8}
+{"abstract_id": "25127697", "label": "results", "text": "Retinal/choroidal thickness values showed no significant correlation ( @-mm : P = @ , r ( @ ) = @ ; @-mm : P = @ , r ( @ ) < @ ; @-mm : P = @ , r ( @ ) = @ ) .", "sentence_id": 9}
+{"abstract_id": "25127697", "label": "results", "text": "No significant difference was found in the @ - or @-mm circle of a retinal peak of edema-centered grid .", "sentence_id": 10}
+{"abstract_id": "25127697", "label": "results", "text": "All other measurements of choroidal/retinal thickness ( DME vs healthy , DME vs peak of edema-centered , DME vs fellow , healthy vs fellow , peak of edema-centered vs healthy , peak of edema-centered vs fellow eyes ) were compared but no statistically significant correlation was found .", "sentence_id": 11}
+{"abstract_id": "25127697", "label": "results", "text": "By tendency a thinner choroid correlates with larger retinal leakage areas .", "sentence_id": 12}
+{"abstract_id": "25127697", "label": "conclusions", "text": "Automated algorithms can be used to reliably assess choroidal thickness in eyes with DME .", "sentence_id": 13}
+{"abstract_id": "25127697", "label": "conclusions", "text": "Choroidal thickness was generally reduced in patients with diabetes if DME is present in @ eye ; however , no correlation was found between choroidal/retinal pathologies , suggesting different pathogenetic pathways .", "sentence_id": 14}
+{"abstract_id": "24756814", "label": "background", "text": "This update of a randomized , prospective study presents the effect of external beam radiation therapy ( EBRT ) on long-term overall survival , local control , and limb function following limb-sparing surgery ( LSS ) for the treatment extremity soft tissue sarcoma ( STS ) .", "sentence_id": 0}
+{"abstract_id": "24756814", "label": "methods", "text": "Following LSS , patients with extremity STS were randomized to receive EBRT or surgery alone .", "sentence_id": 1}
+{"abstract_id": "24756814", "label": "methods", "text": "All patients with high-grade STS received adjuvant chemotherapy .", "sentence_id": 2}
+{"abstract_id": "24756814", "label": "methods", "text": "Long-term follow-up was obtained through telephone interviews using a questionnaire based on validated methods .", "sentence_id": 3}
+{"abstract_id": "24756814", "label": "methods", "text": "Overall survival ( OS ) was determined by Kaplan-Meier method .", "sentence_id": 4}
+{"abstract_id": "24756814", "label": "results", "text": "A total of @ patients with extremity STS were randomized to receive adjuvant EBRT ( n = @ ) or LSS alone ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24756814", "label": "results", "text": "Median follow-up was @ years .", "sentence_id": 6}
+{"abstract_id": "24756814", "label": "results", "text": "The @ - and @-year survival was @ % ( @ % CI @-@ % ) and @ % ( @ % CI @-@ % ) for patients receiving LSS alone and @ % ( @ % CI @-@ % ) and @ % ( @ % CI @-@ % ) for patients receiving EBRT ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24756814", "label": "results", "text": "Of the @ patients who completed telephone interviews , the incidence of local recurrence during the follow-up period was @ % ( @ of @ ) in the LSS alone cohort compared with @ % ( @ of @ ) in those who received EBRT ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24756814", "label": "results", "text": "Patients treated with EBRT tended to have more wound complications ( @ vs. @ % , p = @ ) , clinically significant edema ( @ vs. @ % , p = @ ) , and functional limb deficits ( @ vs. @ % , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24756814", "label": "conclusions", "text": "Adjuvant EBRT following surgery for STS of the extremity provides excellent local control with acceptable treatment-related morbidity and no statistically significant improvement in overall survival .", "sentence_id": 10}
+{"abstract_id": "24820932", "label": "objective", "text": "In this pilot study we evaluated the feasibility of and methods for assessing the quality of life of long term survivors of European Organisation for Research and Treatment of Cancer ( EORTC ) phase III clinical trials .", "sentence_id": 0}
+{"abstract_id": "24820932", "label": "objective", "text": "Here we report the results pertaining to the feasibility of conducting such research .", "sentence_id": 1}
+{"abstract_id": "24820932", "label": "methods", "text": "In this cross-sectional study , we recruited long-term , disease-free survivors from two mature EORTC clinical trials in testicular and prostate cancer from centres in Northern and Southern Europe , and the United Kingdom ( UK ) .", "sentence_id": 2}
+{"abstract_id": "24820932", "label": "results", "text": "A number of challenges were encountered in recruiting participating centres , obtaining medical ethical approval and in recruiting survivors and collecting the health-related quality of life ( HRQoL ) data in a timely manner .", "sentence_id": 3}
+{"abstract_id": "24820932", "label": "results", "text": "The efficiency with which the study could be conducted varied widely across centres and countries .", "sentence_id": 4}
+{"abstract_id": "24820932", "label": "results", "text": "Time to obtain medical ethical approval for the study ranged from @ to @ months .", "sentence_id": 5}
+{"abstract_id": "24820932", "label": "results", "text": "We encountered most problems with ethical approval in the UK , Italy and Belgium .", "sentence_id": 6}
+{"abstract_id": "24820932", "label": "results", "text": "In most cases , data collection was completed within @ months ( range @ weeks-@ year ) .", "sentence_id": 7}
+{"abstract_id": "24820932", "label": "results", "text": "Completed questionnaires were obtained from @ % and @ % , respectively , of the testicular and prostate cancer survivors who were approached .", "sentence_id": 8}
+{"abstract_id": "24820932", "label": "conclusions", "text": "HRQoL research among long-term survivors of EORTC phase III clinical trials is possible , but the process of ethical approval and data collection is a lengthy one .", "sentence_id": 9}
+{"abstract_id": "24820932", "label": "conclusions", "text": "To minimise many of the logistical problems , long-term follow-up of patients should be an integral part of future clinical trials .", "sentence_id": 10}
+{"abstract_id": "24820932", "label": "conclusions", "text": "Moreover , regulations governing medical ethical approval for clinical research within the EU should be carefully evaluated to facilitate long-term follow-up of cancer survivors in Europe .", "sentence_id": 11}
+{"abstract_id": "25339155", "label": "background", "text": "The serum collection under the abdominal flap is the most common complication after a lipo-abdominoplasty .", "sentence_id": 0}
+{"abstract_id": "25339155", "label": "background", "text": "The frequency of seroma increases further among obese patients , who have achieved massive weight loss after bariatric surgery .", "sentence_id": 1}
+{"abstract_id": "25339155", "label": "background", "text": "The purpose of this study is to demonstrate the effectiveness of fibrin glues with a low concentration of thrombin in reducing seroma formation after a lipo-abdominoplasty .", "sentence_id": 2}
+{"abstract_id": "25339155", "label": "methods", "text": "Thirty patients , that had achieved a significant weight loss after an intervention of laparoscopic adjustable gastric banding ( LAGB ) , underwent a circular lipo-abdominoplasty at our bariatric surgery department .", "sentence_id": 3}
+{"abstract_id": "25339155", "label": "methods", "text": "Patients were divided into two groups of @ subjects each : group A underwent traditional surgery ; in group B , we applied a slow-clotting variant of fibrin glue ( ARTISS , Baxter ) under the abdominal flap .", "sentence_id": 4}
+{"abstract_id": "25339155", "label": "methods", "text": "All subjects were evaluated clinically using an ultrasound device on postoperative day @ .", "sentence_id": 5}
+{"abstract_id": "25339155", "label": "methods", "text": "We considered positive for seroma , those cases with a liquid collection greater than @ cc .", "sentence_id": 6}
+{"abstract_id": "25339155", "label": "results", "text": "The groups were homogeneous for age , BMI , male/female ratio , and diabetic or smoker patients .", "sentence_id": 7}
+{"abstract_id": "25339155", "label": "results", "text": "The mean hospital stay was significantly longer in group A than in group B.", "sentence_id": 8}
+{"abstract_id": "25339155", "label": "results", "text": "We found eight cases of serum collection > @ cc in group A and only one case in group B. Hematoma , umbilicus necrosis , and surgical site infection occurred in both groups , but overall complication rate was lower in group B.", "sentence_id": 9}
+{"abstract_id": "25339155", "label": "conclusions", "text": "The use of a fibrin glue with a low concentration of thrombin could be useful during wound closure and may decrease seroma formation in postbariatric patients undergoing lipo-abdominoplasty .", "sentence_id": 10}
+{"abstract_id": "24548796", "label": "background", "text": "Children with pulmonary hypertension routinely undergo pulmonary vascular resistance studies to assess the disease severity and vasodilator responsiveness .", "sentence_id": 0}
+{"abstract_id": "24548796", "label": "background", "text": "It is vital that results are accurate and reliable and are not influenced by the choice of anaesthetic agent .", "sentence_id": 1}
+{"abstract_id": "24548796", "label": "background", "text": "However , there are anecdotal data to suggest that propofol and inhalational agents have different effects on pulmonary vascular resistance .", "sentence_id": 2}
+{"abstract_id": "24548796", "label": "methods", "text": "A total of @ children with pulmonary hypertension were selected sequentially to be included in the study .", "sentence_id": 3}
+{"abstract_id": "24548796", "label": "methods", "text": "To avoid confounding because of baseline anatomic or demographic details , a crossover protocol was implemented , using propofol or isoflurane , with time for washout in between each agent and blinding of the interventionalist .", "sentence_id": 4}
+{"abstract_id": "24548796", "label": "results", "text": "Pulmonary and systemic vascular resistance were not significantly different when using propofol or isoflurane .", "sentence_id": 5}
+{"abstract_id": "24548796", "label": "results", "text": "However , the calculated resistance fraction - ratio of pulmonary resistance to systemic resistance - was significantly lower when using propofol than when using isoflurane .", "sentence_id": 6}
+{"abstract_id": "24548796", "label": "conclusions", "text": "Although no difference in pulmonary vascular resistance was demonstrated , this pilot study suggests that the choice of anaesthetic agent may affect the calculation of relative pulmonary and systemic vascular resistance , and provides some preliminary evidence to favour propofol over isoflurane .", "sentence_id": 7}
+{"abstract_id": "24548796", "label": "conclusions", "text": "These findings require replication in a larger study , and thus they should be considered in future calculations to make informed decisions about the management of children with pulmonary hypertension .", "sentence_id": 8}
+{"abstract_id": "25069770", "label": "background", "text": "Dirofilaria repens is the causative agent of subcutaneous dirofilariosis of dogs , other animals and humans .", "sentence_id": 0}
+{"abstract_id": "25069770", "label": "background", "text": "This nematode is transmitted by mosquitoes of Aedes , Anopheles and Culex genera .", "sentence_id": 1}
+{"abstract_id": "25069770", "label": "background", "text": "In dogs , the parasite may cause subclinical infection or cutaneous signs .", "sentence_id": 2}
+{"abstract_id": "25069770", "label": "background", "text": "Recently , D. repens has emerged and spread in different geographical areas , with an increase of cases in dogs and humans .", "sentence_id": 3}
+{"abstract_id": "25069770", "label": "background", "text": "Chemoprevention in dogs in endemic areas is the most reliable approach for controlling this infection .", "sentence_id": 4}
+{"abstract_id": "25069770", "label": "background", "text": "This paper describes a randomized , blocked and multicentric clinical field study investigating the efficacy of an oral , chewable formulation containing milbemycin oxime/praziquantel ( Milbemax , Novartis Animal Health ) in the chemoprevention of subcutaneous dirofilariosis in dogs .", "sentence_id": 5}
+{"abstract_id": "25069770", "label": "methods", "text": "This study was conducted in endemic areas of Italy .", "sentence_id": 6}
+{"abstract_id": "25069770", "label": "methods", "text": "A total of @ dogs , at two sites , negative for D. repens , were allocated into two groups ( i.e. Treated - T@ vs Untreated-T@ ) with a ratio of @:@ , and subjected to clinical visits and blood sampling once monthly until the end of the study .", "sentence_id": 7}
+{"abstract_id": "25069770", "label": "methods", "text": "All blood samples were microscopically and genetically examined .", "sentence_id": 8}
+{"abstract_id": "25069770", "label": "methods", "text": "Animals belonging to T@ group received a minimum target dose of @ mg/kg bodyweight of milbemycin oxime and @ mg/kg of praziquantel in commercial tablets ( Milbemax ) according body weight once every @ weeks .", "sentence_id": 9}
+{"abstract_id": "25069770", "label": "methods", "text": "Animals of group T@ were not treated with Milbemax but received , when necessary , specific parasiticide treatments .", "sentence_id": 10}
+{"abstract_id": "25069770", "label": "methods", "text": "The study duration was @ @ days for each dog .", "sentence_id": 11}
+{"abstract_id": "25069770", "label": "results", "text": "A total of @ dogs completed the study ( i.e. @ in T@ and @ in T@ ) , while @ dogs ( i.e. @ in T@ , @ in T@ ) were withdrawn for a variety of reasons unrelated to administration of Milbemax .", "sentence_id": 12}
+{"abstract_id": "25069770", "label": "results", "text": "The percentages of animals not showing microfilariae of D. repens were @ % ( @ animals ) in T@ and @ % ( @ animals out of @ ) in group T@ .", "sentence_id": 13}
+{"abstract_id": "25069770", "label": "results", "text": "Milbemax was shown to be safe in treated dogs .", "sentence_id": 14}
+{"abstract_id": "25069770", "label": "conclusions", "text": "The results of this study confirm that the monthly use of Milbemax in dogs is effective and safe for the prevention of subcutaneous dirofilariosis in endemic areas .", "sentence_id": 15}
+{"abstract_id": "24651243", "label": "background", "text": "We investigated whether medial cord stimulation is inferior to posterior cord stimulation for vertical infraclavicular block with respect to block success .", "sentence_id": 0}
+{"abstract_id": "24651243", "label": "methods", "text": "Ninety-six patients scheduled for upper limb surgery were randomly elicited a medial or posterior cord response for infraclavicular block using @ mL of @ % ropivacaine .", "sentence_id": 1}
+{"abstract_id": "24651243", "label": "methods", "text": "We assessed block success ( complete sensory block of the @ nerves in the forearm at @ minutes ) as the primary end point and block procedure characteristics and adverse events as secondary end points .", "sentence_id": 2}
+{"abstract_id": "24651243", "label": "results", "text": "The block success rates did not differ significantly between medial and posterior cord stimulation ( @ % -LSB- @/@ -RSB- vs @ % -LSB- @/@ -RSB- , @ % CI of difference , -@ % to @ % ) , while the secondary end points were comparable in both groups .", "sentence_id": 3}
+{"abstract_id": "24651243", "label": "conclusions", "text": "Needle manipulation to elicit medial cord response is noninferior to posterior cord response of block success during neurostimulation-guided vertical infraclavicular block .", "sentence_id": 4}
+{"abstract_id": "25117066", "label": "background", "text": "Pharmacokinetically guided ( PK-guided ) versus body surface area-based @-fluorouracil ( @-FU ) dosing results in higher response rates and better tolerability .", "sentence_id": 0}
+{"abstract_id": "25117066", "label": "background", "text": "A paucity of data exists on PK-guided @-FU dosing in the community setting .", "sentence_id": 1}
+{"abstract_id": "25117066", "label": "methods", "text": "Seventy colorectal cancer patients , from one academic and five community cancer centers , received the mFOLFOX@ regimen ( @-FU @,@ mg/m ( @ ) over @ hours every @ weeks ) with or without bevacizumab at cycle @ .", "sentence_id": 2}
+{"abstract_id": "25117066", "label": "methods", "text": "The @-FU continuous-infusion dose was adjusted for cycles @-@ using a PK-guided algorithm to achieve a literature-based target area under the concentration-time curve ( AUC ) .", "sentence_id": 3}
+{"abstract_id": "25117066", "label": "methods", "text": "The primary objective was to demonstrate that PK-guided @-FU dosing improves the ability to achieve a target AUC within four cycles of therapy .", "sentence_id": 4}
+{"abstract_id": "25117066", "label": "methods", "text": "The secondary objective was to demonstrate reduced incidence of @-FU-related toxicities .", "sentence_id": 5}
+{"abstract_id": "25117066", "label": "results", "text": "At cycles @ and @ , @ % and @ % of patients achieved the target AUC ( @-@ mg hour/L ) , respectively ( odds ratio -LSB- OR -RSB- : @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25117066", "label": "results", "text": "Significantly more patients were within range at cycle @ compared with a literature rate of @ % ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25117066", "label": "results", "text": "Patients had significantly higher odds of not being underdosed at cycle @ versus cycle @ ( OR : @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25117066", "label": "results", "text": "The odds of a patient being within range increased by @ % at each subsequent cycle ( OR : @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25117066", "label": "results", "text": "Less grade @/@ mucositis and diarrhea were observed compared with historical data ( @ % vs @ % and @ % vs @ % , respectively ) ; however , rates of grade @/@ neutropenia were similar ( @ % vs @ % -@ % ) .", "sentence_id": 10}
+{"abstract_id": "25117066", "label": "conclusions", "text": "PK-guided @-FU dosing resulted in significantly fewer underdosed patients and less gastrointestinal toxicity and allows for the application of personalized colorectal cancer therapy in the community setting .", "sentence_id": 11}
+{"abstract_id": "24815101", "label": "objective", "text": "To assess the side effects unrelated to disease activity and the acceptability of combined oral contraceptives ( COCs ) , progestin-only pills ( POPs ) and copper-releasing intrauterine devices ( IUDs ) in women with systemic lupus erythematosus ( SLE ) .", "sentence_id": 0}
+{"abstract_id": "24815101", "label": "methods", "text": "A randomized clinical trial including @ women with SLE , assigned to COC ( n = @ ) , POP ( n = @ ) or IUD ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24815101", "label": "methods", "text": "Follow-up visits were conducted after @ , @ , @ , @ , @ and @ months of treatment to monitor the presence of symptoms , changes in body weight and blood pressure as well as the development of health problems other than those relating to lupus .", "sentence_id": 2}
+{"abstract_id": "24815101", "label": "methods", "text": "Reasons for discontinuation and satisfaction with the use of the assigned method were recorded at the end of treatment .", "sentence_id": 3}
+{"abstract_id": "24815101", "label": "methods", "text": "Statistical analysis included descriptive statistics , repeated measure analyses and Kaplan-Meier curves .", "sentence_id": 4}
+{"abstract_id": "24815101", "label": "results", "text": "Significantly different discontinuation rates due to any reason -LSB- @ % , @ % , @ % ( p < @ ) -RSB- or nonmedical reasons -LSB- ( @ % , @ % , @ % ( p < @ ) -RSB- were observed among the COC , POP and IUD groups .", "sentence_id": 5}
+{"abstract_id": "24815101", "label": "results", "text": "Nausea was most frequent among COC users , dysmenorrhea among IUD users and acne and hirsutism among POP users .", "sentence_id": 6}
+{"abstract_id": "24815101", "label": "results", "text": "Mean blood pressures remained unchanged .", "sentence_id": 7}
+{"abstract_id": "24815101", "label": "results", "text": "Mild increases in body weight were observed over time in all treatment groups .", "sentence_id": 8}
+{"abstract_id": "24815101", "label": "results", "text": "Most women were satisfied with the use of the assigned contraceptive method .", "sentence_id": 9}
+{"abstract_id": "24815101", "label": "conclusions", "text": "Oral contraceptives and IUD are acceptable birth control methods for patients with lupus , when counseling and specialized health attention are provided ; however , the acceptability of POP appears to be inferior .", "sentence_id": 10}
+{"abstract_id": "24815101", "label": "conclusions", "text": "Side effects unrelated to lupus disease activity are not frequent reasons to discontinue the contraceptive methods .", "sentence_id": 11}
+{"abstract_id": "24815101", "label": "conclusions", "text": "This study delves into an area that has not been explored among patients with lupus .", "sentence_id": 12}
+{"abstract_id": "24815101", "label": "conclusions", "text": "Our findings on the associated side effects and reasons for discontinuing COCs , POPs or copper-bearing IUDs may be useful in improving contraceptive counseling for women with lupus .", "sentence_id": 13}
+{"abstract_id": "24815101", "label": "conclusions", "text": "Furthermore , they also heighten our knowledge on the reasons that may preclude the widespread use of effective contraceptives among lupus patients .", "sentence_id": 14}
+{"abstract_id": "24684165", "label": "background", "text": "Post-inflammatory hyperpigmentation is a frequent concern when treating solar lentigines .", "sentence_id": 0}
+{"abstract_id": "24684165", "label": "objective", "text": "To assess the safety and efficacy of a triple combination cream with fluocinolone acetonide @ % , hydroquinone @ % and tretinoin @ % as adjuvant to cryotherapy in the treatment of solar lentigines in hands dorsum , and in the prevention of post-inflammatory hyperpigmentation after cryotherapy .", "sentence_id": 1}
+{"abstract_id": "24684165", "label": "methods", "text": "This prospective , randomized , controlled , investigator-blinded , single-centre study enrolled @ patients .", "sentence_id": 2}
+{"abstract_id": "24684165", "label": "methods", "text": "Twenty-five patients received a @-week daily triple combination cream plus sunscreen pre-treatment and @ received sunscreen alone .", "sentence_id": 3}
+{"abstract_id": "24684165", "label": "methods", "text": "After that , cryotherapy was performed in all patients followed by a @-week recovery period .", "sentence_id": 4}
+{"abstract_id": "24684165", "label": "methods", "text": "After this period , patients received the same initial treatment and were followed up for @weeks .", "sentence_id": 5}
+{"abstract_id": "24684165", "label": "methods", "text": "Melanin and erythema levels of a target and a control lentigo were objectively measured using a narrowband reflectance spectrophotometer .", "sentence_id": 6}
+{"abstract_id": "24684165", "label": "methods", "text": "Lentigines count , colour homogeneity and global improvement were also assessed .", "sentence_id": 7}
+{"abstract_id": "24684165", "label": "results", "text": "The number of solar lentigines reduced in the first @weeks only in patients who used the triple combination @ vs. @ ( P < @ ) , and reduced at the end of the study for both groups ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24684165", "label": "results", "text": "The melanin levels also reduced in the first @weeks only in patients who used the triple combination @ vs. @ ( P < @ ) and reduced at the end of the study for both groups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24684165", "label": "results", "text": "Erythema and residual blisters from cryotherapy were the reported adverse reactions .", "sentence_id": 10}
+{"abstract_id": "24684165", "label": "conclusions", "text": "Triple combination cream can be used to enhance the resolution of solar lentigines , and to significantly reduce melanin levels and lentigines count , improving treatment results .", "sentence_id": 11}
+{"abstract_id": "24684165", "label": "conclusions", "text": "It was well-tolerated and did not increase the occurrence of neither erythema nor other side-effects after the cryotherapy .", "sentence_id": 12}
+{"abstract_id": "25053749", "label": "objective", "text": "The purpose of this article is to investigate the efficacy and safety of frovatriptan plus dexketoprofen @ or @ mg ( FroDex@ or FroDex@ @ , respectively ) compared to that of frovatriptan @ mg ( Frova ) in menstrually related migraine ( MRM ) .", "sentence_id": 0}
+{"abstract_id": "25053749", "label": "objective", "text": "The aim of this article is to analyze a subgroup of @ women who treated an MRM attack in this multicenter , randomized , double-blind , parallel-group study .", "sentence_id": 1}
+{"abstract_id": "25053749", "label": "methods", "text": "The primary end-point was the proportion of patients who were pain free ( PF ) at two hours .", "sentence_id": 2}
+{"abstract_id": "25053749", "label": "methods", "text": "Secondary end-points included pain-relief ( PR ) at two hours and @ hours sustained pain free ( SPF ) .", "sentence_id": 3}
+{"abstract_id": "25053749", "label": "results", "text": "PF rates at two hours were @ % under Frova , @ % under FroDex@ and @ % under FroDex@ @ ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25053749", "label": "results", "text": "PR at two hours was Frova @ % , FroDex@ @ % and FroDex@ @ @ % , while @ hours SPF was @ % under Frova , @ % under FroDex@ and @ % under FroDex@ @ .", "sentence_id": 5}
+{"abstract_id": "25053749", "label": "conclusions", "text": "Combining frovatriptan + dexketoprofen produced higher PF rates at two hours compared to Frova while maintaining efficacy at @ hours .", "sentence_id": 6}
+{"abstract_id": "25053749", "label": "conclusions", "text": "Tolerability profiles were comparable .", "sentence_id": 7}
+{"abstract_id": "25667975", "label": "objective", "text": "Triage of HPV screen-positive women is needed to identify those with underlying cervical intraepithelial neoplasia grade @/@ or worse ( CIN@/@ + ) .", "sentence_id": 0}
+{"abstract_id": "25667975", "label": "objective", "text": "Presently , cytology on a physician-taken cervical scrape is mostly accepted as triage test , but needs follow-up testing in order not to miss severe disease .", "sentence_id": 1}
+{"abstract_id": "25667975", "label": "objective", "text": "Here , we evaluated the performance of combined cytology and bi-marker CADM@/MAL-methylation analysis as triage test on physician-taken cervical scrapes of HPV positive women .", "sentence_id": 2}
+{"abstract_id": "25667975", "label": "methods", "text": "In this post-hoc analysis , we used @ left-over HPV positive cytology triage samples of participants of a randomized controlled trial ( PROHTECT-@ : n = @,@ ) performed in population-based cervical screening .", "sentence_id": 3}
+{"abstract_id": "25667975", "label": "methods", "text": "Study endpoints were CIN@ + and CIN@ + detection .", "sentence_id": 4}
+{"abstract_id": "25667975", "label": "methods", "text": "Cytology testing with and without methylation marker analysis was evaluated with regard to sensitivity , specificity , positive and negative predictive value , and referral rate .", "sentence_id": 5}
+{"abstract_id": "25667975", "label": "results", "text": "Bi-marker CADM@/MAL-methylation positivity increased proportionally with severity of underlying lesions .", "sentence_id": 6}
+{"abstract_id": "25667975", "label": "results", "text": "Overall , cytology and bi-marker CADM@/MAL-methylation analysis yielded similar performances with regard to CIN@ + detection , yet in combination a significantly higher sensitivity for CIN@ + ( @ % ) was obtained at a specificity of @ % and a colposcopy referral rate of @ % .", "sentence_id": 7}
+{"abstract_id": "25667975", "label": "results", "text": "The combined strategy detected all six cervical cancers , whereas triage by cytology alone failed to detect two of them .", "sentence_id": 8}
+{"abstract_id": "25667975", "label": "conclusions", "text": "Cytology and bi-marker CADM@/MAL-methylation analysis perform complementary for CIN@ + / CIN@ + detection when used as triage tool on cervical scrapes of HPV positive women .", "sentence_id": 9}
+{"abstract_id": "25667975", "label": "conclusions", "text": "This approach not only results in a higher CIN@ + sensitivity than cytology triage with an acceptable referral rate , but also seems to reduce the risk of missing cervical cancers and advanced high-grade lesions .", "sentence_id": 10}
+{"abstract_id": "25347623", "label": "background", "text": "The analgesic efficacy of the transversus abdominis plane peripheral nerve block following abdominal tissue breast reconstruction has not been studied in a randomized controlled trial .", "sentence_id": 0}
+{"abstract_id": "25347623", "label": "methods", "text": "The authors conducted a double-blind , placebo-controlled , @:@ allocation , two-arm parallel group , superiority design , randomized controlled trial in patients undergoing microsurgical abdominally based breast reconstruction .", "sentence_id": 1}
+{"abstract_id": "25347623", "label": "methods", "text": "Intraoperatively , epidural catheters were inserted under direct vision through the triangle of Petit on both sides of the abdomen into the transversus abdominis plane just before rectus fascial closure .", "sentence_id": 2}
+{"abstract_id": "25347623", "label": "methods", "text": "Patients received either bupivacaine ( study group ) or saline ( placebo group ) through the catheters for @ postoperative days .", "sentence_id": 3}
+{"abstract_id": "25347623", "label": "methods", "text": "All patients received hydromorphone by means of a patient-controlled analgesic pump .", "sentence_id": 4}
+{"abstract_id": "25347623", "label": "methods", "text": "The primary outcome was the difference in the parenteral opioid consumption on each postoperative day between the groups .", "sentence_id": 5}
+{"abstract_id": "25347623", "label": "methods", "text": "The secondary outcome measures included the following : total in-hospital opioid ; antinausea medication ; pain , nausea , and sedation scores ; Quality of Recovery Score ; time to ambulation ; and hospital stay duration .", "sentence_id": 6}
+{"abstract_id": "25347623", "label": "results", "text": "Between September of @ and June of @ , @ patients were enrolled : @ received bupivacaine and @ received saline .", "sentence_id": 7}
+{"abstract_id": "25347623", "label": "results", "text": "There were @ postoperative complications ( @ percent ) ; none were related to the catheter .", "sentence_id": 8}
+{"abstract_id": "25347623", "label": "results", "text": "Primary outcomes were completed by @ of @ patients ( @ percent ) ; the mean parenteral morphine consumption was significantly reduced on postoperative day @ in the bupivacaine group ( @ mg ) compared with @ mg in the control group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25347623", "label": "results", "text": "There were no significant differences in secondary outcomes .", "sentence_id": 10}
+{"abstract_id": "25347623", "label": "conclusions", "text": "Following abdominally based breast reconstruction , transversus abdominis plane peripheral nerve block is safe and significantly reduces morphine consumption in the early postoperative period .", "sentence_id": 11}
+{"abstract_id": "25347623", "label": "methods", "text": "Therapeutic , II .", "sentence_id": 12}
+{"abstract_id": "25436350", "label": "objective", "text": "The aim of this study was to comparatively examine the convenience of use of the QUEST and GerdQ questionnaires as self-administered diagnostic instruments .", "sentence_id": 0}
+{"abstract_id": "25436350", "label": "methods", "text": "This was a two-way crossover study conducted from December @ to April @ .", "sentence_id": 1}
+{"abstract_id": "25436350", "label": "methods", "text": "The subjects were @ third-year nursing students of Yokohama Soei University in Yokohama , Japan .", "sentence_id": 2}
+{"abstract_id": "25436350", "label": "methods", "text": "They were randomly assigned to fill in either of the study questionnaires first , and then the other on a later .", "sentence_id": 3}
+{"abstract_id": "25436350", "label": "results", "text": "A significant difference was observed in the questionnaire completion time between the QUEST and GerdQ questionnaires ( @ vs. @ seconds , P < @ ) and also in the number of subjects asking questions while completing the questionnaires ( @ vs. @ subject , respectively : P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25436350", "label": "results", "text": "To detect GERD based on a QUEST score of @ , ROC analysis revealed an area under the curve for the GerdQ score of @ .", "sentence_id": 5}
+{"abstract_id": "25436350", "label": "results", "text": "The optimal cutoff value of the GerdQ score was @ , and the sensitivity and specificity calculated using this cutoff value were @ and @ , respectively .", "sentence_id": 6}
+{"abstract_id": "25436350", "label": "conclusions", "text": "This study revealed that Japanese subjects may find it easier to complete the GerdQ than the QUEST questionnaire .", "sentence_id": 7}
+{"abstract_id": "24756128", "label": "objective", "text": "Prevention of iron deficiency in infancy may promote neurodevelopment .", "sentence_id": 0}
+{"abstract_id": "24756128", "label": "objective", "text": "Delayed cord clamping ( DCC ) can prevent iron deficiency during the first @ months of life .", "sentence_id": 1}
+{"abstract_id": "24756128", "label": "objective", "text": "However , no data are available on long-term effects on infant outcomes in relation to time for umbilical cord clamping .", "sentence_id": 2}
+{"abstract_id": "24756128", "label": "objective", "text": "To investigate effects of DCC , as compared with early cord clamping ( ECC ) , on infant iron status and neurodevelopment at age @ months in a European setting .", "sentence_id": 3}
+{"abstract_id": "24756128", "label": "methods", "text": "Randomized clinical trial of @ full-term infants born after a low-risk pregnancy at a Swedish county hospital .", "sentence_id": 4}
+{"abstract_id": "24756128", "label": "methods", "text": "Follow-up at @ months included evaluation of iron status ( ferritin level , transferrin saturation , transferrin receptor level , reticulocyte hemoglobin level , and mean cell volume ) and parental assessment of neurodevelopment by the Ages and Stages Questionnaire , second edition ( ASQ ) .", "sentence_id": 5}
+{"abstract_id": "24756128", "label": "methods", "text": "Infants were randomized to DCC ( @ seconds after delivery ) or ECC ( @ seconds after delivery ) .", "sentence_id": 6}
+{"abstract_id": "24756128", "label": "methods", "text": "The main outcome was iron status at age @ months ; the secondary outcome was ASQ score .", "sentence_id": 7}
+{"abstract_id": "24756128", "label": "results", "text": "In total , @ of @ infants ( @ % ) were assessed .", "sentence_id": 8}
+{"abstract_id": "24756128", "label": "results", "text": "The DCC and ECC groups did not differ in iron status ( mean ferritin level , @ vs @ ng/mL , respectively ; P = @ ) or neurodevelopment ( mean ASQ total score , @ vs @ , respectively ; P = @ ) at age @ months .", "sentence_id": 9}
+{"abstract_id": "24756128", "label": "results", "text": "Predictors of ferritin levels were infant sex and ferritin in umbilical cord blood .", "sentence_id": 10}
+{"abstract_id": "24756128", "label": "results", "text": "Predictors of ASQ score were infant sex and breastfeeding within @ hour after birth .", "sentence_id": 11}
+{"abstract_id": "24756128", "label": "results", "text": "For both outcomes , being a boy was associated with lower results .", "sentence_id": 12}
+{"abstract_id": "24756128", "label": "results", "text": "Interaction analysis showed that DCC was associated with an ASQ score @ points higher among boys ( mean -LSB- SD -RSB- score , @ -LSB- @ -RSB- for DCC vs @ -LSB- @ -RSB- for ECC ) but @ points lower among girls ( mean -LSB- SD -RSB- score , @ -LSB- @ -RSB- for DCC vs @ -LSB- @ -RSB- for ECC ) , out of a maximum of @ points ( P = @ for the interaction term ) .", "sentence_id": 13}
+{"abstract_id": "24756128", "label": "conclusions", "text": "Delayed cord clamping did not affect iron status or neurodevelopment at age @ months in a selected population of healthy term-born infants .", "sentence_id": 14}
+{"abstract_id": "24756128", "label": "conclusions", "text": "However , it may not be possible to demonstrate minor effects on neurodevelopment with the size of the study population and the chosen method for assessment .", "sentence_id": 15}
+{"abstract_id": "24756128", "label": "conclusions", "text": "The current data indicate that sex may influence the effects on infant development after DCC in different directions .", "sentence_id": 16}
+{"abstract_id": "24756128", "label": "conclusions", "text": "The magnitude and biological reason for this finding remain to be investigated .", "sentence_id": 17}
+{"abstract_id": "24756128", "label": "conclusions", "text": "TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT@ .", "sentence_id": 18}
+{"abstract_id": "25439692", "label": "background", "text": "Dacomitinib is an irreversible pan-HER tyrosine-kinase inhibitor with preclinical and clinical evidence of activity in non-small-cell lung cancer .", "sentence_id": 0}
+{"abstract_id": "25439692", "label": "background", "text": "We designed BR @ to assess whether dacomitinib improved overall survival in heavily pretreated patients with this disease .", "sentence_id": 1}
+{"abstract_id": "25439692", "label": "methods", "text": "In this double-blind , randomised , placebo-controlled , phase @ trial , we enrolled adults ( aged @ years ) with advanced or metastatic non-small-cell lung cancer from @ centres in @ countries .", "sentence_id": 2}
+{"abstract_id": "25439692", "label": "methods", "text": "Eligible patients had received up to three previous lines of chemotherapy and either gefitinib or erlotinib , and had assessable disease ( RECIST @ ) and tumour tissue samples for translational studies .", "sentence_id": 3}
+{"abstract_id": "25439692", "label": "methods", "text": "Patients were stratified according to centre , performance status , tobacco use , best response to previous EGFR tyrosine-kinase inhibitor , weight loss within the previous @ months , and ethnicity , and were then randomly allocated @:@ to oral dacomitinib @ mg once-daily or matched placebo centrally via a web-based system .", "sentence_id": 4}
+{"abstract_id": "25439692", "label": "methods", "text": "Treatment continued until disease progression or unacceptable toxicity .", "sentence_id": 5}
+{"abstract_id": "25439692", "label": "methods", "text": "The primary outcome was overall survival in the intention-to-treat population ; secondary outcomes included overall survival in predefined molecular subgroups , progression-free survival , the proportion of patients who achieved an objective response , safety , and quality of life .", "sentence_id": 6}
+{"abstract_id": "25439692", "label": "methods", "text": "This study is completed , although follow-up is ongoing for patients on treatment .", "sentence_id": 7}
+{"abstract_id": "25439692", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "25439692", "label": "results", "text": "Between Dec @ , @ , and June @ , @ , we randomly assigned @ patients to dacomitinib and @ patients to placebo .", "sentence_id": 9}
+{"abstract_id": "25439692", "label": "results", "text": "At the final analysis ( January , @ ) , median follow-up was @ months ( IQR @-@ ) for patients in the dacomitinib group and @ months ( @-@ ) for those in the placebo group .", "sentence_id": 10}
+{"abstract_id": "25439692", "label": "results", "text": "Dacomitinib did not improve overall survival compared with placebo ( median @ months -LSB- @ % CI @-@ -RSB- for dacomitinib vs @ months -LSB- @-@ -RSB- for placebo ; hazard ratio -LSB- HR -RSB- @ -LSB- @ % CI @-@ -RSB- ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25439692", "label": "results", "text": "However , patients in the dacomitinib group had longer progression-free survival than those in the placebo group ( median @ months -LSB- @-@ -RSB- vs @ months -LSB- @-@ -RSB- , respectively ; HR @ -LSB- @ % CI @-@ -RSB- ; p < @ ) , and a significantly greater proportion of patients in the dacomitinb group achieved an objective response than in the placebo group ( @ -LSB- @ % -RSB- of @ patients vs three -LSB- @ % -RSB- of @ patients , respectively ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25439692", "label": "results", "text": "Compared with placebo , the effect of dacomitinib on overall survival seemed similar in patients with EGFR-mutation-positive tumours ( HR @ , @ % CI @-@ ) and EGFR wild-type tumours ( @ , @-@ ; pinteraction = @ ) .", "sentence_id": 13}
+{"abstract_id": "25439692", "label": "results", "text": "However , we noted qualitative differences in the effect of dacomitinib on overall survival for patients with KRAS-mutation-positive tumours ( @ , @-@ ) and patients with KRAS wild-type tumours ( @ , @-@ ; pinteraction = @ ) .", "sentence_id": 14}
+{"abstract_id": "25439692", "label": "results", "text": "Compared with placebo , patients allocated dacomitinib had significantly longer time to deterioration of cough ( p < @ ) , dyspnoea ( p = @ ) , and pain ( p = @ ) .", "sentence_id": 15}
+{"abstract_id": "25439692", "label": "results", "text": "@ ( @ % ) of @ patients who received dacomitinib and @ ( @ % ) of @ patients who received placebo had serious adverse events .", "sentence_id": 16}
+{"abstract_id": "25439692", "label": "results", "text": "The most common grade @-@ adverse events were diarrhoea ( @ -LSB- @ % -RSB- patients on dacomitinib vs no controls ) , acneiform rash ( @ -LSB- @ % -RSB- vs one -LSB- < @ % -RSB- ) , oral mucositis ( @ -LSB- @ % -RSB- vs none ) , and fatigue ( @ -LSB- @ % -RSB- vs four -LSB- @ % -RSB- ) .", "sentence_id": 17}
+{"abstract_id": "25439692", "label": "conclusions", "text": "Dacomitinib did not increase overall survival and can not be recommended for treatment of patients with advanced non-small-cell lung cancer previously treated with chemotherapy and an EGFR tyrosine-kinase inhibitor .", "sentence_id": 18}
+{"abstract_id": "24333184", "label": "objective", "text": "Treatment for CH-C contains interferon with substantial associated side effects and health-related quality of life ( HRQL ) impairment .", "sentence_id": 0}
+{"abstract_id": "24333184", "label": "objective", "text": "Currently , there is no published data assessing the impact of interferon-free regimens on HRQL .", "sentence_id": 1}
+{"abstract_id": "24333184", "label": "objective", "text": "The aim is to report the HRQL of patients who participated in clinical trials of sofosbuvir ( SOF ) for CH-C .", "sentence_id": 2}
+{"abstract_id": "24333184", "label": "methods", "text": "CH-C patients were treated with sofosbuvir ( SOF ) , pegylated interferon ( PegIFN ) , ribavirin ( RBV ) , or placebo in different combinations and duration ( POSITRON , FISSION , FUSION , and NEUTRINO phase III trials ) .", "sentence_id": 3}
+{"abstract_id": "24333184", "label": "methods", "text": "HRQL was assessed using SF-@ at baseline , during treatment , at the end of treatment , and at follow-up , and compared between treatment arms .", "sentence_id": 4}
+{"abstract_id": "24333184", "label": "results", "text": "HRQL scores decreased over the course of treatment for all treatment arms in all studies ; however , patients returned to their baseline score by the end of follow-up .", "sentence_id": 5}
+{"abstract_id": "24333184", "label": "results", "text": "Compared to placebo , SOF and RBV was not associated with HRQL impairment ( POSITRON ) .", "sentence_id": 6}
+{"abstract_id": "24333184", "label": "results", "text": "Compared to SOF and RBV , HRQL was significantly more impaired in the PegIFN and RBV arm ( FISSION ) .", "sentence_id": 7}
+{"abstract_id": "24333184", "label": "results", "text": "For those treated with SOF and RBV , there was no difference in HRQL between @ weeks or @ weeks of treatment ( FUSION ) .", "sentence_id": 8}
+{"abstract_id": "24333184", "label": "results", "text": "Multivariate analysis demonstrated that depression , fatigue , and insomnia were important predictors of patients ' HRQL prior , during or after treatment .", "sentence_id": 9}
+{"abstract_id": "24333184", "label": "results", "text": "Additionally , anemia and receiving interferon were predictors of HRQL impairment during treatment .", "sentence_id": 10}
+{"abstract_id": "24333184", "label": "results", "text": "Achieving sustained virologic response after @ weeks of follow-up ( SVR-@ ) with SOF and RBV was associated with improvement in HRQL scores from baseline .", "sentence_id": 11}
+{"abstract_id": "24333184", "label": "conclusions", "text": "Treatment-related HRQL impairment during SOF and RBV regimen is mild , and does not increase with longer treatment duration .", "sentence_id": 12}
+{"abstract_id": "24333184", "label": "conclusions", "text": "Achieving SVR-@ with SOF and RBV is associated with an improvement in HRQL .", "sentence_id": 13}
+{"abstract_id": "24866985", "label": "background", "text": "Fetal Alcohol Spectrum Disorders ( FASDs ) are the leading known preventable birth defects in North America .", "sentence_id": 0}
+{"abstract_id": "24866985", "label": "background", "text": "Knowledge surveys about FASD have been conducted with various health and allied healthcare providers and have proven useful in identifying gaps in knowledge and differences among provider groups to support prevention efforts .", "sentence_id": 1}
+{"abstract_id": "24866985", "label": "background", "text": "To date , no research has been conducted exploring FASD knowledge among college students .", "sentence_id": 2}
+{"abstract_id": "24866985", "label": "objective", "text": "This study explored FASD knowledge in a sample of college students , a group at particularly high risk for alcohol-exposed pregnancies .", "sentence_id": 3}
+{"abstract_id": "24866985", "label": "objective", "text": "Findings are compared to professionals in several healthcare and affiliated professional groups who were previously surveyed with the same FASD-related items .", "sentence_id": 4}
+{"abstract_id": "24866985", "label": "methods", "text": "Surveys from @,@ college students at a northwestern university were analyzed .", "sentence_id": 5}
+{"abstract_id": "24866985", "label": "methods", "text": "Included with the ACHA-National College Health Assessment II were questions regarding FASD .", "sentence_id": 6}
+{"abstract_id": "24866985", "label": "methods", "text": "College students ' knowledge was compared with that of professionals in key healthcare and affiliated positions to define their relative awareness of FASD risk .", "sentence_id": 7}
+{"abstract_id": "24866985", "label": "results", "text": "Overall , findings revealed adequate FASD knowledge among college students .", "sentence_id": 8}
+{"abstract_id": "24866985", "label": "results", "text": "Although minor differences emerged when comparing students and professionals ' responses , most respondent groups answered with an @ % accuracy rate or higher .", "sentence_id": 9}
+{"abstract_id": "24866985", "label": "conclusions", "text": "College students demonstrated adequate knowledgeable about FASD .", "sentence_id": 10}
+{"abstract_id": "24866985", "label": "conclusions", "text": "Future research must explore whether such knowledge translates into lower risk behavior and consequent reduction in alcohol-exposed pregnancies .", "sentence_id": 11}
+{"abstract_id": "25140931", "label": "background", "text": "High - and low-frequency repetitive transcranial magnetic stimulation ( HF-rTMS and LF-rTMS ) has been shown to be beneficial for upper limb hemiparesis in patients with acute stroke .", "sentence_id": 0}
+{"abstract_id": "25140931", "label": "background", "text": "However , no study has examined the usefulness of bilateral application of HF - and LF-rTMS ( BL-rTMS ) .", "sentence_id": 1}
+{"abstract_id": "25140931", "label": "methods", "text": "Fifty-eight hemiparetic patients with acute stroke were randomly assigned into two groups : HF-rTMS group and BL-rTMS group .", "sentence_id": 2}
+{"abstract_id": "25140931", "label": "methods", "text": "All patients were scheduled to receive five sessions of either HF-rTMS over the lesional hemisphere or BL-rTMS over both hemispheres for @ days .", "sentence_id": 3}
+{"abstract_id": "25140931", "label": "methods", "text": "Motor function of the affected upper limb was evaluated using the Brunnstrom Recovery Stage ( BRS ) for upper-limb and hand-fingers , grip strength and tapping frequency , before the first session and after the last session of rTMS .", "sentence_id": 4}
+{"abstract_id": "25140931", "label": "results", "text": "Improvement of BRS for the upper limb and hand/finger was significantly greater in the BL-rTMS group than the HF-rTMS group ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25140931", "label": "results", "text": "Improvement in grip strength and tapping frequency was also greater in the BL-rTMS group , although the differences were not statistically significant .", "sentence_id": 6}
+{"abstract_id": "25140931", "label": "conclusions", "text": "The proposed BL-rTMS is safe and feasible and showed a greater improvement of BRS of the affected upper limb compared to HF-rTMS .", "sentence_id": 7}
+{"abstract_id": "25140931", "label": "conclusions", "text": "This novel rTMS approach may be a useful intervention for hemiparetic patients with acute stroke .", "sentence_id": 8}
+{"abstract_id": "24997003", "label": "background", "text": "The evaluation of intestinal trophism , mainly the mucosal layer , is an important issue in various conditions associated with injury , atrophy , recovery , and healing of the gut .", "sentence_id": 0}
+{"abstract_id": "24997003", "label": "background", "text": "The aim of the present study was to evaluate the kinetics of the proliferation and apoptosis of enterocytes by immunohistochemistry and to assess the complexity of intestinal mucosa by fractal dimension ( FD ) analysis in Solea solea fed different experimental diets .", "sentence_id": 1}
+{"abstract_id": "24997003", "label": "results", "text": "Histomorphological evaluation of all intestinal segments did not show signs of degeneration or inflammation .", "sentence_id": 2}
+{"abstract_id": "24997003", "label": "results", "text": "Cell proliferation index and FD were significantly reduced with a diet high in mussel meal ( MM ; p = @ and p = @ , respectively ) , while apoptotic index did not show any significant difference for the same comparison ( p = @ ) .", "sentence_id": 3}
+{"abstract_id": "24997003", "label": "results", "text": "Linear regression analysis between apoptotic index ( independent variable ) and FD ( dependent variable ) showed a statistically significant inverse relationship ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24997003", "label": "results", "text": "Linear regression analysis between cell proliferation index ( independent variable ) and FD ( dependent variable ) did not show any significant correlation ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24997003", "label": "conclusions", "text": "The results demonstrated that diets containing increasing levels of mussel meal in substitution of fishmeal did not incite a hyperplastic response of the intestinal mucosa .", "sentence_id": 6}
+{"abstract_id": "24997003", "label": "conclusions", "text": "The mussel meal , which is derived from molluscs , could mimic the characteristics of the sole 's natural prey , being readily digestible , even without increasing the absorptive surface of intestinal mucosa .", "sentence_id": 7}
+{"abstract_id": "24997003", "label": "conclusions", "text": "Interestingly , from this study emerged that FD could be used as a numeric indicator complementary to in situ quantification methods to measure intestinal trophism , in conjunction with functional parameters .", "sentence_id": 8}
+{"abstract_id": "25970252", "label": "objective", "text": "It is unclear whether d-cycloserine ( DCS ) , a partial N-methyl-d-aspartate agonist that enhances fear extinction , can augment the effects of exposure-based cognitive behavioral therapy ( CBT ) for obsessive-compulsive disorder ( OCD ) .", "sentence_id": 0}
+{"abstract_id": "25970252", "label": "objective", "text": "To examine whether DCS augments the effects of CBT for OCD and to explore ( post hoc ) whether concomitant antidepressant medication moderates the effects of DCS .", "sentence_id": 1}
+{"abstract_id": "25970252", "label": "methods", "text": "A @-week , double-blind randomized clinical trial with @-month follow-up conducted at an academic medical center between September @ , @ , and September @ , @ .", "sentence_id": 2}
+{"abstract_id": "25970252", "label": "methods", "text": "Participants included @ adult outpatients with a primary diagnosis of OCD and a Yale-Brown Obsessive Compulsive Scale ( Y-BOCS ) score of @ or higher .", "sentence_id": 3}
+{"abstract_id": "25970252", "label": "methods", "text": "Concurrent antidepressant medication was permitted if the dose had been stable for at least @ months prior to enrollment and remained unchanged during the trial .", "sentence_id": 4}
+{"abstract_id": "25970252", "label": "methods", "text": "The main analysis was by intention-to-treat population .", "sentence_id": 5}
+{"abstract_id": "25970252", "label": "methods", "text": "All participants received a previously validated Internet-based CBT protocol over @ weeks and were randomized to receive either @ mg of DCS or placebo , administered @ hour before each of @ exposure and response prevention tasks .", "sentence_id": 6}
+{"abstract_id": "25970252", "label": "methods", "text": "Clinician-administered Y-BOCS score at week @ and at @-month follow-up .", "sentence_id": 7}
+{"abstract_id": "25970252", "label": "methods", "text": "Remission was defined as a score of @ or lower on the Y-BOCS .", "sentence_id": 8}
+{"abstract_id": "25970252", "label": "results", "text": "In the primary intention-to-treat analyses , DCS did not augment the effects of CBT compared with placebo ( mean -LSB- SD -RSB- clinician-rated Y-BOCS score , DCS : @ -LSB- @ -RSB- at week @ and @ -LSB- @ -RSB- at @-month follow-up ; placebo : @ -LSB- @ -RSB- at week @ and @ -LSB- @ -RSB- at @-month follow-up ) but showed a significant interaction with antidepressants ( clinician-rated Y-BOCS , B = -@ ; Z = -@ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25970252", "label": "results", "text": "Post hoc analyses revealed that antidepressants significantly impaired treatment response in the DCS group but not the placebo group , at both posttreatment and follow-up ( clinician-rated Y-BOCS : t@ = -@ ; P = @ ; and t@ = -@ ; P < @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "25970252", "label": "results", "text": "In the DCS group , a significantly greater proportion of antidepressant-free patients achieved remission status at follow-up ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) than antidepressant-medicated patients ( @ % -LSB- @ % CI , @ % -@ % -RSB- ) ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25970252", "label": "results", "text": "Antidepressants had no effect in the placebo group ( @ % -LSB- @ % CI , @ % -@ % -RSB- remission rate in both groups ) .", "sentence_id": 12}
+{"abstract_id": "25970252", "label": "conclusions", "text": "The findings suggest that antidepressants may interact with DCS to block its facilitating effect on fear extinction .", "sentence_id": 13}
+{"abstract_id": "25970252", "label": "conclusions", "text": "Use of DCS may be a promising CBT augmentation strategy but only in antidepressant-free patients with OCD .", "sentence_id": 14}
+{"abstract_id": "24666826", "label": "background", "text": "Acute heart failure ( AHF ) is characterized by inadequate cardiac output ( CO ) , congestive symptoms , poor peripheral perfusion and end-organ dysfunction .", "sentence_id": 0}
+{"abstract_id": "24666826", "label": "background", "text": "Treatment often includes a combination of diuretics , oxygen , positive pressure ventilation , inotropes and vasodilators or vasopressors .", "sentence_id": 1}
+{"abstract_id": "24666826", "label": "background", "text": "Lactate is a marker of illness severity but is also an important metabolic substrate for the myocardium at rest and during stress .", "sentence_id": 2}
+{"abstract_id": "24666826", "label": "background", "text": "We tested the effects of half-molar sodium lactate infusion on cardiac performance in AHF .", "sentence_id": 3}
+{"abstract_id": "24666826", "label": "methods", "text": "We conducted a prospective , randomised , controlled , open-label , pilot clinical trial in @ patients fulfilling two of the following three criteria for AHF : ( @ ) left ventricular ejection fraction < @ % , ( @ ) acute pulmonary oedema or respiratory failure of predominantly cardiac origin requiring mechanical ventilation and ( @ ) currently receiving vasopressor and/or inotropic support .", "sentence_id": 4}
+{"abstract_id": "24666826", "label": "methods", "text": "Patients in the intervention group received a @ ml/kg bolus of half-molar sodium lactate over the course of @ minutes followed by @ ml/kg/h continuous infusion for @ hours .", "sentence_id": 5}
+{"abstract_id": "24666826", "label": "methods", "text": "The control group received only a @ ml/kg bolus of Hartmann 's solution without continuous infusion .", "sentence_id": 6}
+{"abstract_id": "24666826", "label": "methods", "text": "The primary outcome was CO assessed by transthoracic echocardiography @ hours after randomisation .", "sentence_id": 7}
+{"abstract_id": "24666826", "label": "methods", "text": "Secondary outcomes included a measure of right ventricular systolic function ( tricuspid annular plane systolic excursion ( TAPSE ) ) , acid-base balance , electrolyte and organ function parameters , along with length of stay and mortality .", "sentence_id": 8}
+{"abstract_id": "24666826", "label": "results", "text": "The infusion of half-molar sodium lactate increased ( meanSD ) CO from @ L/min to @ L/min ( P < @ ) and TAPSE from @ mm to @ mm ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24666826", "label": "results", "text": "Plasma sodium and pH increased ( @ to @ and @ to @ , respectively ; both P < @ ) , but potassium , chloride and phosphate levels decreased .", "sentence_id": 10}
+{"abstract_id": "24666826", "label": "results", "text": "There were no significant differences in the need for vasoactive therapy , respiratory support , renal or liver function tests , duration of ICU and hospital stay or @ - and @-day mortality .", "sentence_id": 11}
+{"abstract_id": "24666826", "label": "conclusions", "text": "Infusion of half-molar sodium lactate improved cardiac performance and led to metabolic alkalosis in AHF patients without any detrimental effects on organ function .", "sentence_id": 12}
+{"abstract_id": "25482425", "label": "background", "text": "Experimental data indicate that reducing factor XI levels attenuates thrombosis without causing bleeding , but the role of factor XI in the prevention of postoperative venous thrombosis in humans is unknown .", "sentence_id": 0}
+{"abstract_id": "25482425", "label": "background", "text": "FXI-ASO ( ISIS @ ) is a second-generation antisense oligonucleotide that specifically reduces factor XI levels .", "sentence_id": 1}
+{"abstract_id": "25482425", "label": "background", "text": "We compared the efficacy and safety of FXI-ASO with those of enoxaparin in patients undergoing total knee arthroplasty .", "sentence_id": 2}
+{"abstract_id": "25482425", "label": "methods", "text": "In this open-label , parallel-group study , we randomly assigned @ patients who were undergoing elective primary unilateral total knee arthroplasty to receive one of two doses of FXI-ASO ( @ mg or @ mg ) or @ mg of enoxaparin once daily .", "sentence_id": 3}
+{"abstract_id": "25482425", "label": "methods", "text": "The primary efficacy outcome was the incidence of venous thromboembolism ( assessed by mandatory bilateral venography or report of symptomatic events ) .", "sentence_id": 4}
+{"abstract_id": "25482425", "label": "methods", "text": "The principal safety outcome was major or clinically relevant nonmajor bleeding .", "sentence_id": 5}
+{"abstract_id": "25482425", "label": "results", "text": "Around the time of surgery , the mean ( SE ) factor XI levels were @ units per milliliter in the @-mg FXI-ASO group , @ units per milliliter in the @-mg FXI-ASO group , and @ units per milliliter in the enoxaparin group .", "sentence_id": 6}
+{"abstract_id": "25482425", "label": "results", "text": "The primary efficacy outcome occurred in @ of @ patients ( @ % ) who received the @-mg dose of FXI-ASO and in @ of @ patients ( @ % ) who received the @-mg dose of FXI-ASO , as compared with @ of @ patients ( @ % ) who received enoxaparin .", "sentence_id": 7}
+{"abstract_id": "25482425", "label": "results", "text": "The @-mg regimen was noninferior , and the @-mg regimen was superior , to enoxaparin ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25482425", "label": "results", "text": "Bleeding occurred in @ % , @ % , and @ % of the patients in the three study groups , respectively .", "sentence_id": 9}
+{"abstract_id": "25482425", "label": "conclusions", "text": "This study showed that factor XI contributes to postoperative venous thromboembolism ; reducing factor XI levels in patients undergoing elective primary unilateral total knee arthroplasty was an effective method for its prevention and appeared to be safe with respect to the risk of bleeding .", "sentence_id": 10}
+{"abstract_id": "25482425", "label": "conclusions", "text": "( Funded by Isis Pharmaceuticals ; FXI-ASO TKA ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24666696", "label": "background", "text": "Inhalation of capsaicin , the extract of hot chili peppers , induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid @ ( TRPV@ ) on airway sensory nerves .", "sentence_id": 0}
+{"abstract_id": "24666696", "label": "background", "text": "Therefore the TRPV@ receptor is an attractive target for the development of antitussive agents .", "sentence_id": 1}
+{"abstract_id": "24666696", "label": "objective", "text": "We sought to assess the antitussive effect of TRPV@ antagonism in patients with refractory chronic cough .", "sentence_id": 2}
+{"abstract_id": "24666696", "label": "methods", "text": "Twenty-one subjects with refractory chronic cough ( > @ weeks ) attending a specialist clinic were recruited to a randomized , double-blind , placebo-controlled crossover trial assessing a TRPV@ antagonist ( SB-@ ) .", "sentence_id": 3}
+{"abstract_id": "24666696", "label": "methods", "text": "Cough reflex sensitivity to capsaicin ( concentration of capsaicin inducing at least @ coughs ) and @-hour cough frequency were coprimary end points assessed after a single dose of SB-@ ( @ mg ) and matched placebo .", "sentence_id": 4}
+{"abstract_id": "24666696", "label": "methods", "text": "Cough severity and urge to cough were reported on visual analog scales , and cough-specific quality of life data were also collected .", "sentence_id": 5}
+{"abstract_id": "24666696", "label": "results", "text": "Treatment with SB-@ produced a significant improvement in cough reflex sensitivity to capsaicin at @ hours and a borderline significant improvement at @ hours compared with placebo ( adjusted mean difference of +@ doubling doses at @ hours -LSB- @ % CI , +@ to +@ ; P = @ -RSB- and +@ doubling doses at @ hours -LSB- @ % CI , +@ to +@ ; P = @ -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "24666696", "label": "results", "text": "However , @-hour objective cough frequency was not improved compared with placebo .", "sentence_id": 7}
+{"abstract_id": "24666696", "label": "results", "text": "Patient-reported cough severity , urge to cough , and cough-specific quality of life similarly suggested no effect of SB-@ .", "sentence_id": 8}
+{"abstract_id": "24666696", "label": "conclusions", "text": "This study raises important questions about both the role of TRVP@-mediated mechanisms in patients with refractory chronic cough and also the predictive value of capsaicin challenge testing in the assessment of novel antitussive agents .", "sentence_id": 9}
+{"abstract_id": "24220704", "label": "objective", "text": "To develop an optimal model and age-specific centiles for the decline in antimllerian hormone ( AMH ) as measured by the new Beckman Coulter AMH Generation II ( Gen II ) assay and compare this to the previous nomogram derived for the Diagnostics Systems Laboratory ( DSL ) assay .", "sentence_id": 0}
+{"abstract_id": "24220704", "label": "methods", "text": "Multicenter retrospective population study , with validation of linear , biphasic linear , differential , power , and quadratic equations .", "sentence_id": 1}
+{"abstract_id": "24220704", "label": "methods", "text": "Two clinical pathology laboratories .", "sentence_id": 2}
+{"abstract_id": "24220704", "label": "methods", "text": "A new cohort of @,@ women aged @ to @ years old attending infertility clinics , randomly divided into a training cohort of @,@ women and a validation cohort of @,@ women , and an existing cohort of @,@ women , who had contributed to the development and validation of a nomogram for AMH measured by the DSL assay .", "sentence_id": 3}
+{"abstract_id": "24220704", "label": "methods", "text": "Serum measurement of AMH as determined by the Beckman Coulter AMH Generation II assay in @,@ women .", "sentence_id": 4}
+{"abstract_id": "24220704", "label": "methods", "text": "Optimal model for the decline in AMH as measured by the AMH Gen II assay with age , with age-specific @th , @th , @th , @th , @th , @th , and @th percentiles .", "sentence_id": 5}
+{"abstract_id": "24220704", "label": "results", "text": "A quadratic model defined as ( @ + @ * Age + -@ * Age ( @ ) ) fitted the decline in AMH with age .", "sentence_id": 6}
+{"abstract_id": "24220704", "label": "results", "text": "The anticipated @ % increase in age-specific population values relative to the previously validated DSL assay nomogram was not observed .", "sentence_id": 7}
+{"abstract_id": "24220704", "label": "conclusions", "text": "Age-specific reference ranges for the AMH gen II assay suggest a systematic shift in assay calibration since initial evaluation and commercial release of the AMH Gen II assay .", "sentence_id": 8}
+{"abstract_id": "24886034", "label": "background", "text": "Mild cognitive impairment ( MCI ) is a condition characterized by memory problems that are more severe than the normal cognitive changes due to aging , but less severe than dementia .", "sentence_id": 0}
+{"abstract_id": "24886034", "label": "background", "text": "Reduced working memory ( WM ) is regarded as one of the core symptoms of an MCI condition .", "sentence_id": 1}
+{"abstract_id": "24886034", "label": "background", "text": "Recent studies have indicated that WM can be improved through computer-based training .", "sentence_id": 2}
+{"abstract_id": "24886034", "label": "background", "text": "The objective of this study is to evaluate if WM training is effective in improving cognitive function in elderly patients with MCI , and if cognitive training induces structural changes in the white and gray matter of the brain , as assessed by structural MRI .", "sentence_id": 3}
+{"abstract_id": "24886034", "label": "methods", "text": "The proposed study is a blinded , randomized , controlled trail that will include @ elderly patients diagnosed with MCI at a hospital-based memory clinic .", "sentence_id": 4}
+{"abstract_id": "24886034", "label": "methods", "text": "The participants will be randomized to either a training program or a placebo version of the program .", "sentence_id": 5}
+{"abstract_id": "24886034", "label": "methods", "text": "The intervention is computerized WM training performed for @minutes of @ sessions over @weeks .", "sentence_id": 6}
+{"abstract_id": "24886034", "label": "methods", "text": "The placebo version is identical in duration but is non-adaptive in the difficulty level of the tasks .", "sentence_id": 7}
+{"abstract_id": "24886034", "label": "methods", "text": "Neuropsychological assessment and structural MRI will be performed before and @ month after training , and at a @-month folllow-up .", "sentence_id": 8}
+{"abstract_id": "24886034", "label": "conclusions", "text": "If computer-based training results in positive changes to memory functions in patients with MCI this may represent a new , cost-effective treatment for MCI .", "sentence_id": 9}
+{"abstract_id": "24886034", "label": "conclusions", "text": "Secondly , evaluation of any training-induced structural changes to gray or white matter will improve the current understanding of the mechanisms behind effective cognitive interventions in patients with MCI .", "sentence_id": 10}
+{"abstract_id": "24294837", "label": "objective", "text": "We compared mindfulness-based cognitive therapy ( MBCT ) with both cognitive psychological education ( CPE ) and treatment as usual ( TAU ) in preventing relapse to major depressive disorder ( MDD ) in people currently in remission following at least @ previous episodes .", "sentence_id": 0}
+{"abstract_id": "24294837", "label": "methods", "text": "A randomized controlled trial in which @ participants were allocated in the ratio @:@:@ to MBCT plus TAU , CPE plus TAU , and TAU alone , and data were analyzed for the @ ( @ % ; MBCT = @ , CPE = @ , TAU = @ ) retained to follow-up .", "sentence_id": 1}
+{"abstract_id": "24294837", "label": "methods", "text": "MBCT was delivered in accordance with its published manual , modified to address suicidal cognitions ; CPE was modeled on MBCT , but without training in meditation .", "sentence_id": 2}
+{"abstract_id": "24294837", "label": "methods", "text": "Both treatments were delivered through @ weekly classes .", "sentence_id": 3}
+{"abstract_id": "24294837", "label": "results", "text": "Allocated treatment had no significant effect on risk of relapse to MDD over @ months follow-up , hazard ratio for MBCT vs. CPE = @ , @ % CI -LSB- @ , @ -RSB- ; for MBCT vs. TAU = @ , @ % CI -LSB- @ , @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "24294837", "label": "results", "text": "However , severity of childhood trauma affected relapse , hazard ratio for increase of @ standard deviation = @ ( @ % CI -LSB- @ , @ -RSB- ) , and significantly interacted with allocated treatment .", "sentence_id": 5}
+{"abstract_id": "24294837", "label": "results", "text": "Among participants above median severity , the hazard ratio was @ , @ % CI -LSB- @ , @ -RSB- , for MBCT vs. CPE , and @ , @ % CI -LSB- @ , @ -RSB- , for MBCT vs. TAU .", "sentence_id": 6}
+{"abstract_id": "24294837", "label": "results", "text": "For those below median severity , there were no such differences between treatment groups .", "sentence_id": 7}
+{"abstract_id": "24294837", "label": "conclusions", "text": "MBCT provided significant protection against relapse for participants with increased vulnerability due to history of childhood trauma , but showed no significant advantage in comparison to an active control treatment and usual care over the whole group of patients with recurrent depression .", "sentence_id": 8}
+{"abstract_id": "25233569", "label": "background", "text": "The aim of this study was to evaluate the patient 's perceived pain response to injection and anesthetic deposition for the greater palatine nerve block .", "sentence_id": 0}
+{"abstract_id": "25233569", "label": "methods", "text": "Heft-Parker Visual Analog Scale ( VAS ) pain scale measurements were used to compare the following techniques for the injection : ( @ ) control ( no concurrent stimulation ) , ( @ ) pressure , ( @ ) pressure and topical anesthetic ( @ % benzocaine ) , and ( @ ) pressure and cold ( TFE ) .", "sentence_id": 1}
+{"abstract_id": "25233569", "label": "methods", "text": "Forty-two volunteers , @ male and @ female , participated in the study .", "sentence_id": 2}
+{"abstract_id": "25233569", "label": "methods", "text": "A bilateral model was used on each patient to give an injection on each side of the palate with two different techniques followed by the next appointment ( > or = two weeks later ) , when the two other injection techniques were used .", "sentence_id": 3}
+{"abstract_id": "25233569", "label": "methods", "text": "Following injection given in the supine position , the patients were returned to an upright position and asked to rate their pain on a VAS .", "sentence_id": 4}
+{"abstract_id": "25233569", "label": "results", "text": "Pain upon needle insertion appears less than that of anesthetic deposition .", "sentence_id": 5}
+{"abstract_id": "25233569", "label": "results", "text": "There was no statistically significant difference in perceived pain response among the four techniques , the visit , the order , the side , or patient gender at either time point .", "sentence_id": 6}
+{"abstract_id": "25233569", "label": "results", "text": "Following the application of Endo Ice , @ % of participants reported a sore on their palate occurring two to @ hours after cold application and persisting for one to @ days .", "sentence_id": 7}
+{"abstract_id": "25233569", "label": "results", "text": "The pain score for this injection had a mean value of @ % ( @ / @ ) .", "sentence_id": 8}
+{"abstract_id": "25233569", "label": "conclusions", "text": "This prospective , single-blind study evaluating three injection techniques to reduce posterior palatal injection pain to a control injection method showed no significant reduction in pain with any of the three techniques .", "sentence_id": 9}
+{"abstract_id": "25233569", "label": "conclusions", "text": "Furthermore , @,@,@,@-tetrafluoroethane placed with pressure for @ seconds appeared injurious to the oral mucosa .", "sentence_id": 10}
+{"abstract_id": "25034216", "label": "background", "text": "Continuous glucose monitoring ( CGM ) has been shown to improve glucose control in adults with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25034216", "label": "background", "text": "Effectiveness of CGM is directly linked with CGM adherence , which can be challenging to maintain in children and adolescents .", "sentence_id": 1}
+{"abstract_id": "25034216", "label": "background", "text": "We hypothesize that initiating CGM at the same time as starting insulin pump therapy in pump nave children and adolescents with type @ diabetes will result in greater CGM adherence and effectiveness compared to delaying CGM introduction by @ months , and that this is related to greater readiness for making behaviour change at the time of pump initiation .", "sentence_id": 2}
+{"abstract_id": "25034216", "label": "methods", "text": "The CGM TIME Trial is a multicenter randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "25034216", "label": "methods", "text": "Eligible children and adolescents ( @-@ years ) with established type @ diabetes were randomized to simultaneous initiation of pump ( Medtronic Veo ) and CGM ( Enlite ) or to standard pump therapy with delayed CGM introduction .", "sentence_id": 4}
+{"abstract_id": "25034216", "label": "methods", "text": "Primary outcomes are CGM adherence and hemoglobin A@C at @ and @ months post pump initiation .", "sentence_id": 5}
+{"abstract_id": "25034216", "label": "methods", "text": "Secondary outcomes include glycemic variability , stage of readiness , and other patient-reported outcomes with follow-up to @ months .", "sentence_id": 6}
+{"abstract_id": "25034216", "label": "methods", "text": "@ ( @ % ) of the @ eligible patients were enrolled and randomized .", "sentence_id": 7}
+{"abstract_id": "25034216", "label": "methods", "text": "Allowing for @ % withdrawals , this will provide @ % power to detect a between group difference in CGM adherence and @ % power to detect a between group difference in hemoglobin A@C .", "sentence_id": 8}
+{"abstract_id": "25034216", "label": "methods", "text": "Baseline characteristics were similar between the treatment groups .", "sentence_id": 9}
+{"abstract_id": "25034216", "label": "methods", "text": "Analysis of @ month primary outcomes will begin in September @ .", "sentence_id": 10}
+{"abstract_id": "25034216", "label": "conclusions", "text": "The CGM TIME Trial is the first study to examine the relationship between timing of CGM initiation , readiness for behaviour change , and subsequent CGM adherence in pump nave children and adolescents .", "sentence_id": 11}
+{"abstract_id": "25034216", "label": "conclusions", "text": "Its findings will advance our understanding of when and how to initiate CGM in children and adolescents with type @ diabetes .", "sentence_id": 12}
+{"abstract_id": "25262434", "label": "objective", "text": "Early statin therapy after acute coronary syndrome reduces atherothrombotic vascular events .", "sentence_id": 0}
+{"abstract_id": "25262434", "label": "objective", "text": "This study aimed to compare the effects of hydrophilic and hydrophobic statins on myocardial salvage and left ventricular ( LV ) function in patients with ST-elevated myocardial infarction ( STEMI ) .", "sentence_id": 1}
+{"abstract_id": "25262434", "label": "methods", "text": "Seventy-five STEMI patients who had received emergency reperfusion therapy were enrolled and randomized into the hydrophilic statin group ( rosuvastatin ; @ mg/day , n = @ ) and hydrophobic statin group ( atorvastatin ; @ mg/day , n = @ ) for @ months .", "sentence_id": 2}
+{"abstract_id": "25262434", "label": "methods", "text": "LV ejection fraction ( LVEF ) , and B-type natriuretic peptide ( BNP ) and co-enzyme Q@ ( CoQ@ ) levels were measured at baseline and the end of treatment .", "sentence_id": 3}
+{"abstract_id": "25262434", "label": "methods", "text": "The myocardial salvage index was assessed by single photon emission computed tomography with ( @ - ) I -- methyl-iodophenylpentadecanoic acid ( ischemic area-at-risk at onset of STEMI : AAR ) and ( @ - ) thallium scintigraphy ( area-at-infarction at @ months : AAI ) -LSB- myocardial salvage index = ( AAR-AAI ) @/AAR ( % ) -RSB- .", "sentence_id": 4}
+{"abstract_id": "25262434", "label": "results", "text": "Onset-to-balloon time and maximum creatine phosphokinase levels were comparable between the groups .", "sentence_id": 5}
+{"abstract_id": "25262434", "label": "results", "text": "After @ months , rosuvastatin ( -@ % @ % ) and atorvastatin ( -@ % @ % ) equally reduced low-density lipoprotein-cholesterol ( LDL-C ) levels ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25262434", "label": "results", "text": "However , rosuvastatin ( +@ % @ % , p < @ ) , but not atorvastatin ( +@ % @ % , p = @ ) , improved LVEF .", "sentence_id": 7}
+{"abstract_id": "25262434", "label": "results", "text": "Rosuvastatin reduced BNP levels compared with atorvastatin ( -@ % @ % versus -@ % @ % , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25262434", "label": "results", "text": "The myocardial salvage index was significantly higher in the rosuvastatin group than the atorvastatin group ( @ % @ % versus @ % @ % , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25262434", "label": "results", "text": "CoQ@/LDL-C levels at @ months were increased in the rosuvastatin group ( +@ % , p < @ ) and percent changes in CoQ@/LDL-C were correlated with the myocardial salvage index ( r = @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25262434", "label": "conclusions", "text": "Rosuvastatin shows better beneficial effects on myocardial salvage than atorvastatin in STEMI patients , including long-term cardiac function , associated with increasing CoQ@/LDL-C .", "sentence_id": 11}
+{"abstract_id": "24746254", "label": "background", "text": "Laparoscopic common bile duct exploration ( LCBDE ) is now one of the main methods for treating choledocholithiasis accompanied with cholelithiasis .", "sentence_id": 0}
+{"abstract_id": "24746254", "label": "background", "text": "The objective of our study was to assess the safety and effectiveness of laparoscopic primary closure for the treatment of common bile duct ( CBD ) stones compared with T-tube drainage .", "sentence_id": 1}
+{"abstract_id": "24746254", "label": "methods", "text": "Patients who underwent CBD stones were studied prospectively from @-@ in a single center .", "sentence_id": 2}
+{"abstract_id": "24746254", "label": "methods", "text": "A total of @ patients were randomly assigned to group A ( LCBDE with primary closure ) with @ cases and group B ( LCBDE with T-tube drainage ) with @ cases .", "sentence_id": 3}
+{"abstract_id": "24746254", "label": "methods", "text": "Intraoperative cholangiography and choledochoscopy were performed in all patients .", "sentence_id": 4}
+{"abstract_id": "24746254", "label": "methods", "text": "Patient demographics , intraoperative findings , postoperative stay , complications , and hospital expenses were recorded and analyzed .", "sentence_id": 5}
+{"abstract_id": "24746254", "label": "results", "text": "There was no mortality in the two groups .", "sentence_id": 6}
+{"abstract_id": "24746254", "label": "results", "text": "Four patients ( @ % ) of group A were converted to open surgery , and three patients ( @ % ) in group B.", "sentence_id": 7}
+{"abstract_id": "24746254", "label": "results", "text": "The mean operating time was much shorter in group A than in group B ( @ @ min versus @ @ min , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24746254", "label": "results", "text": "The length of postoperative hospital stay was longer in group B ( @ @ d ) than in group A ( @ @ d ) .", "sentence_id": 9}
+{"abstract_id": "24746254", "label": "results", "text": "The hospital expenses were significantly lower in group A. Three patients experienced postoperative complications , which were related to the usage of the T-tube in group B.", "sentence_id": 10}
+{"abstract_id": "24746254", "label": "results", "text": "The incidences of overall postoperative complications were insignificantly lower in group A.", "sentence_id": 11}
+{"abstract_id": "24746254", "label": "conclusions", "text": "Laparoscopic primary closure of CBD is safe and effective for the management of CBD stones , and can be performed routinely as an alternative to T-tube drainage .", "sentence_id": 12}
+{"abstract_id": "24325584", "label": "objective", "text": "A recently discovered myokine , irisin , may have an important role in energy metabolism .", "sentence_id": 0}
+{"abstract_id": "24325584", "label": "objective", "text": "This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome ( MetS ) following a hypocaloric diet .", "sentence_id": 1}
+{"abstract_id": "24325584", "label": "methods", "text": "Ninety-three Caucasian adults ( @ men/@ women ) diagnosed with MetS followed an @-week-long energy-restricted programme ( -@ % of the energy requirements ) .", "sentence_id": 2}
+{"abstract_id": "24325584", "label": "methods", "text": "Anthropometric measurements , biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention .", "sentence_id": 3}
+{"abstract_id": "24325584", "label": "results", "text": "Global plasma irisin levels were significantly reduced at the end of the study ( -@ @ ng/ml , P < @ ) accompanying the weight loss ( -@ % ) .", "sentence_id": 4}
+{"abstract_id": "24325584", "label": "results", "text": "The depletion of irisin significantly correlated with changes in some atherogenic-related variables : total cholesterol ( B = @ , P = @ ) , total cholesterol/high-density lipoprotein cholesterol ratio ( B = @ , P = @ ) , low-density lipoprotein cholesterol ( B = @ , P = @ ) and apolipoprotein B ( B = @ , P = @ ) , independently of changes in body weight .", "sentence_id": 5}
+{"abstract_id": "24325584", "label": "conclusions", "text": "An association between the reduction in plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy-restricted programme .", "sentence_id": 6}
+{"abstract_id": "25012957", "label": "background", "text": "The @-valent pneumococcal polysaccharide vaccine is recommended for elders , especially those with chronic conditions .", "sentence_id": 0}
+{"abstract_id": "25012957", "label": "objective", "text": "The aim of this study was to determine if an additional multi-component health education intervention increases the uptake rate of the pneumococcal vaccination among older patients with chronic diseases .", "sentence_id": 1}
+{"abstract_id": "25012957", "label": "methods", "text": "A cluster randomized controlled trial was conducted from @ December @ to @ March @ .", "sentence_id": 2}
+{"abstract_id": "25012957", "label": "methods", "text": "The clusters were the individual weeks within five Hong Kong outpatient clinics over a @-week period .", "sentence_id": 3}
+{"abstract_id": "25012957", "label": "methods", "text": "A sample of @ patients aged @ or above with chronic diseases was recruited .", "sentence_id": 4}
+{"abstract_id": "25012957", "label": "methods", "text": "Intervention group received a @-min brief telephone education intervention before and a @-min face-to-face intervention during scheduled medical appointments at the respective clinics .", "sentence_id": 5}
+{"abstract_id": "25012957", "label": "methods", "text": "All subjects received standard care including health education leaflets and/or a video show at the clinics .", "sentence_id": 6}
+{"abstract_id": "25012957", "label": "methods", "text": "Pneumococcal vaccination rate and awareness of the vaccination at @-month follow up were measured .", "sentence_id": 7}
+{"abstract_id": "25012957", "label": "results", "text": "The vaccination rate was higher in the intervention group compared to the control group ( @ % vs @ % ; relative risk = @ , @ % CI = @-@ @ ) , but the two groups did not differ significantly in their awareness of the vaccination at @-month follow up ( @ % vs @ % , relative risk = @ , @ % CI = @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25012957", "label": "conclusions", "text": "A nurse-delivered brief health education intervention was effective in increasing uptake of pneumococcal vaccination among older patients with chronic diseases .", "sentence_id": 9}
+{"abstract_id": "25035114", "label": "background", "text": "In assessing quality of care in developing countries , retrospectively collected data are usually used given their availability .", "sentence_id": 0}
+{"abstract_id": "25035114", "label": "background", "text": "Retrospective data however suffer from such biases as recall bias and non-response bias .", "sentence_id": 1}
+{"abstract_id": "25035114", "label": "background", "text": "Comparing results obtained using prospectively and retrospectively collected data will help validate the use of the easily available retrospective data in assessing quality of care in past and future studies .", "sentence_id": 2}
+{"abstract_id": "25035114", "label": "methods", "text": "Prospective and retrospective datasets were obtained from a cluster randomized trial of a multifaceted intervention aimed at improving paediatric inpatient care conducted in eight rural Kenyan district hospitals by improving management of children admitted with pneumonia , malaria and diarrhea and/or dehydration .", "sentence_id": 3}
+{"abstract_id": "25035114", "label": "methods", "text": "Four hospitals received a full intervention and four a partial intervention .", "sentence_id": 4}
+{"abstract_id": "25035114", "label": "methods", "text": "Data were collected through @ two weeks surveys conducted at baseline , after @ and @ months .", "sentence_id": 5}
+{"abstract_id": "25035114", "label": "methods", "text": "Retrospective data was sampled from paediatric medical records of patients discharged in the preceding six months of the survey while prospective data was collected from patients discharged during the two week period of each survey .", "sentence_id": 6}
+{"abstract_id": "25035114", "label": "methods", "text": "Risk Differences during post-intervention period of @ quality of care indicators were analyzed separately for prospective and retrospective datasets and later plotted side by side for comparison .", "sentence_id": 7}
+{"abstract_id": "25035114", "label": "results", "text": "For the prospective data there was strong evidence of an intervention effect for @ of the indicators and weaker evidence of an effect for one indicator , with magnitude of effect sizes varying from @ % to @ % difference .", "sentence_id": 8}
+{"abstract_id": "25035114", "label": "results", "text": "For the retrospective data , @ process ( these include the @ indicators found to be statistically significant in prospective data analysis ) indicators had statistically significant differences with magnitude of effects varying from @ % to @ % .", "sentence_id": 9}
+{"abstract_id": "25035114", "label": "results", "text": "The bar-graph comparing results from the prospective and retrospective datasets showed similarity in terms of magnitude of effects and statistical significance for all except two indicators .", "sentence_id": 10}
+{"abstract_id": "25035114", "label": "conclusions", "text": "Multifaceted interventions can help improve adoption of clinical guidelines and hence improve the quality of care .", "sentence_id": 11}
+{"abstract_id": "25035114", "label": "conclusions", "text": "The similar inference reached after analyses based on prospective assessment of case management is a useful finding as it supports the utility of work based on examination of retrospectively assembled case records allowing longer time periods to be studied while constraining costs .", "sentence_id": 12}
+{"abstract_id": "24863954", "label": "objective", "text": "Poor patient understanding of their diagnosis and treatment plan can adversely impact clinical outcome following hospital discharge .", "sentence_id": 0}
+{"abstract_id": "24863954", "label": "objective", "text": "Discharge summaries are primarily written for the doctor rather than the patient .", "sentence_id": 1}
+{"abstract_id": "24863954", "label": "objective", "text": "We determined patient understanding of the reasons for hospitalisation , in-hospital tests , treatments and post-discharge recommendations , and whether a brief patient-directed discharge letter ( PADDLE ) delivered during a brief discussion prior to discharge would improve understanding .", "sentence_id": 2}
+{"abstract_id": "24863954", "label": "methods", "text": "A prospective randomised controlled trial was conducted , including @ hospitalised patients .", "sentence_id": 3}
+{"abstract_id": "24863954", "label": "methods", "text": "After a baseline questionnaire , patients were randomised to receive the PADDLE letter or usual care .", "sentence_id": 4}
+{"abstract_id": "24863954", "label": "methods", "text": "Those receiving the letter had an immediate follow-up questionnaire .", "sentence_id": 5}
+{"abstract_id": "24863954", "label": "methods", "text": "Patient understanding was compared with a summary letter written by the treating clinician , using a @-point Likert scale ranging from none to full understanding .", "sentence_id": 6}
+{"abstract_id": "24863954", "label": "methods", "text": "A questionnaire was administered at @ and @ months .", "sentence_id": 7}
+{"abstract_id": "24863954", "label": "results", "text": "At baseline , patients had almost full understanding ( median score @ ) of reasons for hospitalisation and treatments .", "sentence_id": 8}
+{"abstract_id": "24863954", "label": "results", "text": "However , despite high self-appraisal , patients objectively had very little understanding of tests performed and post-discharge recommendations ( median @ ) .", "sentence_id": 9}
+{"abstract_id": "24863954", "label": "results", "text": "Those receiving the letter had an immediate increase to almost full understanding ( median @ ) of tests performed ( P < @ ) and to full understanding ( median @ ) of post-discharge recommendations .", "sentence_id": 10}
+{"abstract_id": "24863954", "label": "results", "text": "This increase did not persist at @ or @ months .", "sentence_id": 11}
+{"abstract_id": "24863954", "label": "conclusions", "text": "A simple patient-directed letter delivered during a brief discussion improves patient understanding of their hospitalisation and post-discharge recommendations , which is otherwise limited .", "sentence_id": 12}
+{"abstract_id": "24863954", "label": "conclusions", "text": "Further evaluation of this brief and well-received intervention is indicated , with the goal of improving patient understanding , satisfaction and clinical outcomes .", "sentence_id": 13}
+{"abstract_id": "25315148", "label": "background", "text": "Patient reported outcome measures ( PROMs ) are used to evaluate lifestyle interventions but little is known about differences between patients returning valid and invalid responses , or of potential for bias in evaluations .", "sentence_id": 0}
+{"abstract_id": "25315148", "label": "background", "text": "We aimed to examine the characteristics of patients who returned valid responses to lifestyle questionnaires compared to those whose responses were invalid for evaluating lifestyle change .", "sentence_id": 1}
+{"abstract_id": "25315148", "label": "methods", "text": "We conducted a secondary data analysis from the SPHERE Study , a trial of an intervention to improve outcomes for patients with coronary heart disease in primary care .", "sentence_id": 2}
+{"abstract_id": "25315148", "label": "methods", "text": "Postal questionnaires were used to assess physical activity ( Godin ) and diet ( DINE ) among study participants at baseline and @ month follow-up .", "sentence_id": 3}
+{"abstract_id": "25315148", "label": "methods", "text": "Three binary response variables were generated for analysis : ( @ ) valid Godin score ; ( @ ) valid DINE Fibre score ; and ( @ ) valid DINE Total Fat score .", "sentence_id": 4}
+{"abstract_id": "25315148", "label": "methods", "text": "Multivariate analysis comprised generalised estimating equation regression to examine the association of patients ' characteristics with their return of valid responses at both timepoints .", "sentence_id": 5}
+{"abstract_id": "25315148", "label": "results", "text": "Overall , @ % of participants ( @/@ ) returned questionnaires at both baseline and @ months .", "sentence_id": 6}
+{"abstract_id": "25315148", "label": "results", "text": "Relatively fewer valid Godin scores were returned by those who left school aged < @ years ( @ % ) than aged @ and over ( @ % ) , manual workers ( @ % ) than non-manual ( @ % ) and those with an elevated cholesterol ( > @ mmol ) ( @ % ) than those with a lower cholesterol ( @ % ) but multivariate analysis identified that only school leaving age ( p = @ ) was of statistical significance.Relatively fewer valid DINE scores were returned by manual than non-manual workers ( fibre : @ % v @ % ; fat : @ % v @ % ) , smokers ( fibre : @ % v @ % ; fat : @ % v @ % ) , patients with diabetes ( fibre : @ % v @ % ; fat : @ % v @ % ) and those with cholesterol > @ mmol ( fat : @ % v @ % ) but multivariate analysis showed statistical significance only for smoking ( fibre : p = @ ; fat : p = @ ) , diabetes ( fibre : p = @ ; fat : p = @ ) , and cholesterol ( fat : p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25315148", "label": "conclusions", "text": "Our findings illustrate the importance of detailed reporting of research methods , with clear information about response rates , respondents and valid outcome data .", "sentence_id": 8}
+{"abstract_id": "25315148", "label": "conclusions", "text": "Outcome measures which are relevant to a study population should be chosen carefully .", "sentence_id": 9}
+{"abstract_id": "25315148", "label": "conclusions", "text": "The impact of methods of outcome measurement and valid response rates in evaluating healthcare requires further study .", "sentence_id": 10}
+{"abstract_id": "24304291", "label": "background", "text": "Previous studies have shown that a calcium ( Ca ) pre-rinse given before a @ ppm fluoride ( F ) rinse greatly increased salivary fluoride .", "sentence_id": 0}
+{"abstract_id": "24304291", "label": "background", "text": "Objectives .", "sentence_id": 1}
+{"abstract_id": "24304291", "label": "background", "text": "The aim of this randomized controlled trial is to examine if Ca pre-rinse could increase the fluoride concentration in the overnight unstimulated saliva after a @ ppm F-rinse .", "sentence_id": 2}
+{"abstract_id": "24304291", "label": "methods", "text": "Pre-rinses containing @ mM , @ mM or @ mM Ca-lactate prepared by a validated pharmaceutical cGPM procedure were tested by nine subjects in a randomized order immediately followed by a @ ppm F-rinse .", "sentence_id": 3}
+{"abstract_id": "24304291", "label": "methods", "text": "The fluoride concentration was measured in unstimulated saliva collected @ h later .", "sentence_id": 4}
+{"abstract_id": "24304291", "label": "conclusions", "text": "The Ca pre-treatment significantly increased F level in overnight saliva following the @ ppm fluoride rinse by @ relative to the @ ppm F-rinse alone ; however , a significant effect was only observed with the highest ( @ mM ) Ca concentration as pre-rinse .", "sentence_id": 5}
+{"abstract_id": "24304291", "label": "conclusions", "text": "Clinical relevance .", "sentence_id": 6}
+{"abstract_id": "24304291", "label": "conclusions", "text": "High concentration F rinses ( @ ppm ) are commonly recommended for patients at high-risk of caries .", "sentence_id": 7}
+{"abstract_id": "24304291", "label": "conclusions", "text": "A pre-treatment with high levels of Ca may further improve the cariostatic effect of this ion .", "sentence_id": 8}
+{"abstract_id": "25035882", "label": "objective", "text": "Social media sites , such as Facebook , merge two factors that influence risk for eating disorders : media and peers .", "sentence_id": 0}
+{"abstract_id": "25035882", "label": "objective", "text": "Previous work has identified cross-sectional and temporal associations between Facebook use and disordered eating .", "sentence_id": 1}
+{"abstract_id": "25035882", "label": "objective", "text": "This study sought to replicate and extend these findings using an experimental design .", "sentence_id": 2}
+{"abstract_id": "25035882", "label": "methods", "text": "In Study @ , @ women completed self-report surveys regarding Facebook use and disordered eating .", "sentence_id": 3}
+{"abstract_id": "25035882", "label": "methods", "text": "In Study @ , @ women were randomly assigned to use Facebook or to use an alternate internet site for @ min .", "sentence_id": 4}
+{"abstract_id": "25035882", "label": "results", "text": "More frequent Facebook use was associated with greater disordered eating in a cross-sectional survey .", "sentence_id": 5}
+{"abstract_id": "25035882", "label": "results", "text": "Facebook use was associated with the maintenance of weight/shape concerns and state anxiety compared to an alternate internet activity .", "sentence_id": 6}
+{"abstract_id": "25035882", "label": "conclusions", "text": "Facebook use may contribute to disordered eating by maintaining risk for eating pathology .", "sentence_id": 7}
+{"abstract_id": "25035882", "label": "conclusions", "text": "As such , targeting Facebook use may be helpful in intervention and prevention programs .", "sentence_id": 8}
+{"abstract_id": "25294250", "label": "background", "text": "Oritavancin is a lipoglycopeptide antibiotic with rapid bactericidal activity against gram-positive bacteria .", "sentence_id": 0}
+{"abstract_id": "25294250", "label": "background", "text": "Its concentration-dependent activity and long half-life allow for single-dose treatment .", "sentence_id": 1}
+{"abstract_id": "25294250", "label": "methods", "text": "In a randomized , double-blind trial , adults with acute bacterial skin and skin structure infections ( ABSSSIs ) received either a single intravenous @-mg dose of oritavancin or @-@ days of twice-daily vancomycin .", "sentence_id": 2}
+{"abstract_id": "25294250", "label": "methods", "text": "Three efficacy endpoints were tested for noninferiority : ( @ ) primary composite endpoint at @-@ hours ( cessation of spreading or reduction in lesion size , absence of fever , and no rescue antibiotic ) ; ( @ ) investigator-assessed clinical cure @-@ days after end of treatment ; and ( @ ) @ % reduction in lesion area at @-@ hours .", "sentence_id": 3}
+{"abstract_id": "25294250", "label": "results", "text": "A total of @ and @ patients comprised the modified intent-to-treat population for oritavancin and vancomycin , respectively .", "sentence_id": 4}
+{"abstract_id": "25294250", "label": "results", "text": "All @ efficacy endpoints met the @ % noninferiority margin : the primary composite endpoint ( @ % vs @ % ; @ % confidence interval -LSB- CI -RSB- , -@ to @ ) , investigator-assessed clinical cure ( @ % vs @ % ; @ % CI , -@ to @ ) , and proportion of patients attaining @ % reduction in lesion area ( @ % vs @ % ; @ % CI , -@ to @ ) for oritavancin vs vancomycin , respectively .", "sentence_id": 5}
+{"abstract_id": "25294250", "label": "results", "text": "Efficacy outcomes by pathogen , including methicillin-resistant Staphylococcus aureus and the frequency of adverse events , were similar between treatment groups .", "sentence_id": 6}
+{"abstract_id": "25294250", "label": "conclusions", "text": "A single @-mg dose of oritavancin was noninferior to @-@ days of vancomycin in treating ABSSSIs caused by gram-positive pathogens , and was well tolerated .", "sentence_id": 7}
+{"abstract_id": "25294250", "label": "conclusions", "text": "Oritavancin provides a single-dose alternative to multidose therapies for the treatment of ABSSSIs .", "sentence_id": 8}
+{"abstract_id": "25294250", "label": "conclusions", "text": "Clinical Trials Registration .", "sentence_id": 9}
+{"abstract_id": "25294250", "label": "conclusions", "text": "NCT@ .", "sentence_id": 10}
+{"abstract_id": "24528934", "label": "objective", "text": "To test a combination of dexamethasone intravitreal implant with macular grid laser for macular edema in patients with branch retinal vein occlusion ( BRVO ) .", "sentence_id": 0}
+{"abstract_id": "24528934", "label": "methods", "text": "Prospective interventional , randomized , multicenter study .", "sentence_id": 1}
+{"abstract_id": "24528934", "label": "methods", "text": "Patients with macular edema secondary to BRVO underwent an Ozurdex intravitreal implant at baseline .", "sentence_id": 2}
+{"abstract_id": "24528934", "label": "methods", "text": "After @ month , patients were randomly assigned to @ study groups .", "sentence_id": 3}
+{"abstract_id": "24528934", "label": "methods", "text": "Patients in Group @ were followed up monthly and retreated with Ozurdex implant whenever there was a recurrence of macular edema or a decrease in best-corrected visual acuity ( BCVA ) .", "sentence_id": 4}
+{"abstract_id": "24528934", "label": "methods", "text": "In Group @ patients macular grid laser was performed between weeks @ and @ .", "sentence_id": 5}
+{"abstract_id": "24528934", "label": "methods", "text": "After that , patients were followed up and retreated as for Group @ .", "sentence_id": 6}
+{"abstract_id": "24528934", "label": "results", "text": "In Group @ at @ months , mean BCVA was @ @ logMAR and central retinal thickness ( CRT ) was @ @ m ; both improved significantly at @ months , to @ @ logMAR and @ @ m , respectively .", "sentence_id": 7}
+{"abstract_id": "24528934", "label": "results", "text": "In Group @ , CRT was reduced significantly to @ @ m at @ months , and BCVA improved to @ @ logMAR .", "sentence_id": 8}
+{"abstract_id": "24528934", "label": "results", "text": "At the final visit , BCVA was @ @ logMAR and mean CRT was @ @ m.", "sentence_id": 9}
+{"abstract_id": "24528934", "label": "results", "text": "The number of Ozurdex implants at @ months was @ of @ ( @ % ) in Group @ patients vs @ of @ ( @ % ) in Group @ patients ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24528934", "label": "results", "text": "At @ months @ of @ patients ( @ % ) in Group @ vs @ of @ ( @ % ) in Group @ ( P = @ ) were retreated .", "sentence_id": 11}
+{"abstract_id": "24528934", "label": "conclusions", "text": "The combination of Ozurdex implant and macular grid laser is synergistic in increasing BCVA and lengthening the time between injections .", "sentence_id": 12}
+{"abstract_id": "25122150", "label": "background", "text": "Pulmonary arterial hypertension ( PAH ) is a progressive disease with high rates of morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "25122150", "label": "background", "text": "Current therapies improve symptoms , functional capacity , and , in select cases , survival .", "sentence_id": 1}
+{"abstract_id": "25122150", "label": "background", "text": "Little is known about patient factors that may predict the likelihood of patient-important , clinically relevant responses to therapy such as the @-min walk distance ( @MWD ) and health-related quality of life ( HRQoL ) .", "sentence_id": 2}
+{"abstract_id": "25122150", "label": "methods", "text": "Data from the randomized clinical trial of tadalafil in PAH were used .", "sentence_id": 3}
+{"abstract_id": "25122150", "label": "methods", "text": "Adjusted logistic regression models were created to examine the relationship between baseline characteristics and odds of achieving the minimal important difference ( MID ) in three parameters , defined as either a > @-m increase in @MWD , a > @-unit increase in physical component summary score of the Medical Outcomes Study Short Form-@ ( SF-@ ) , or a > @-unit increase in mental component summary score of the SF-@ .", "sentence_id": 4}
+{"abstract_id": "25122150", "label": "results", "text": "The study included @ subjects .", "sentence_id": 5}
+{"abstract_id": "25122150", "label": "results", "text": "Younger age , male sex , lower baseline @MWD , and disease etiology were associated with greater odds of achieving the MID for the @-min walk test .", "sentence_id": 6}
+{"abstract_id": "25122150", "label": "results", "text": "Active treatment , younger age , and male sex were associated with greater odds of achieving the MID for the physical component summary score .", "sentence_id": 7}
+{"abstract_id": "25122150", "label": "results", "text": "Male sex was associated with greater odds of achieving the MID for the mental component summary score .", "sentence_id": 8}
+{"abstract_id": "25122150", "label": "conclusions", "text": "Age , sex , baseline functional capacity , and disease etiology are variably associated with the likelihood of achieving clinically relevant responses in patient-important outcomes to PAH-specific therapy such as @MWD and HRQoL .", "sentence_id": 9}
+{"abstract_id": "25122150", "label": "conclusions", "text": "The increased likelihood of response in men compared with women is a novel finding and may reflect pathophysiologic differences between sexes .", "sentence_id": 10}
+{"abstract_id": "24288395", "label": "background", "text": "Vascular calcification is a potent predictor of plaque instability and cardiac events .", "sentence_id": 0}
+{"abstract_id": "24288395", "label": "background", "text": "Osteoprotegerin ( OPG ) , well-known vascular calcification mediator , is a signaling molecule involved in bone remodeling , which has been implicated in the regulation of vascular calcification and atherogenesis .", "sentence_id": 1}
+{"abstract_id": "24288395", "label": "background", "text": "The purpose of this study was to compare the combination treatments of olmesartan/azelnidipine and olmesartan/diuretics on serum bone-related markers in patients with essential hypertension .", "sentence_id": 2}
+{"abstract_id": "24288395", "label": "results", "text": "A total of @ patients with hypertension treated with @ mg olmesartan were randomized to receive combination treatment with @ mg azelnidipine ( O/A group ) or diuretics ( @ mg indapamide ; O/D group ) for @ months .", "sentence_id": 3}
+{"abstract_id": "24288395", "label": "results", "text": "Osteoprotegerin , matrix metalloproteinase @ ( MMP-@ ) , and high-sensitive CRP ( hs-CRP ) were measured after @ and @ months of treatment .", "sentence_id": 4}
+{"abstract_id": "24288395", "label": "results", "text": "Cardio-ankle vascular index ( CAVI ) was measured as the arterial stiffness using a VaSera CAVI instrument at the same time points .", "sentence_id": 5}
+{"abstract_id": "24288395", "label": "results", "text": "In both groups , the systolic and diastolic blood pressure reduction is similar .", "sentence_id": 6}
+{"abstract_id": "24288395", "label": "results", "text": "Serum OPG , MMP-@ , and hs-CRP were significantly decreased at @ months in the O/A group ( P < @ ) , while there were no significant reductions in the O/D group .", "sentence_id": 7}
+{"abstract_id": "24288395", "label": "results", "text": "CAVI was significantly improved at @ months in both the treatment groups .", "sentence_id": 8}
+{"abstract_id": "24288395", "label": "results", "text": "The improvement in CAVI was significantly greater in the O/A group than in the O/D group .", "sentence_id": 9}
+{"abstract_id": "24288395", "label": "conclusions", "text": "Azelnidipine , but not indapamide , combined with olmesartan , improved arterial stiffness and were associated with significant decrease in OPG , MMP-@ , and hs-CRP concentrations .", "sentence_id": 10}
+{"abstract_id": "24288395", "label": "conclusions", "text": "These results suggest that the beneficial effects of the combination treatments of olmesartan/azelnidipine on arterial stiffness are mediated by alteration in bone-remodeling and inflammatory markers .", "sentence_id": 11}
+{"abstract_id": "25653199", "label": "background", "text": "Excessive alcohol use is a prevalent and worldwide problem .", "sentence_id": 0}
+{"abstract_id": "25653199", "label": "background", "text": "Excessive drinking causes a significant burden of disease and is associated with both morbidity and excess mortality .", "sentence_id": 1}
+{"abstract_id": "25653199", "label": "background", "text": "Prototype alteration and provision of a cue reminder could be useful strategies to enhance the effectiveness of online tailored interventions for excessive drinking .", "sentence_id": 2}
+{"abstract_id": "25653199", "label": "objective", "text": "Through a Web-based randomized controlled trial , @ strategies ( ie , prototype alteration and cue reminders ) within an existing online personalized feedback intervention ( Drinktest ) aimed to reduce adults ' excessive drinking .", "sentence_id": 3}
+{"abstract_id": "25653199", "label": "objective", "text": "It was expected that both strategies would add to Drinktest and would result in reductions in alcohol consumption by intrinsic motivation and the seizure of opportunities to act .", "sentence_id": 4}
+{"abstract_id": "25653199", "label": "methods", "text": "Participants were recruited online and through printed materials .", "sentence_id": 5}
+{"abstract_id": "25653199", "label": "methods", "text": "Excessive drinking adults ( N = @ ) were randomly assigned to @ conditions : original Drinktest , Drinktest plus prototype alteration , Drinktest plus cue reminder , and Drinktest plus prototype alteration and cue reminder .", "sentence_id": 6}
+{"abstract_id": "25653199", "label": "methods", "text": "Evaluation took place at @-month posttest and @-month follow-up .", "sentence_id": 7}
+{"abstract_id": "25653199", "label": "methods", "text": "Differences in drinking behavior , intentions , and behavioral willingness ( ie , primary outcomes ) were assessed by means of longitudinal multilevel analyses using a last observation carried forward method .", "sentence_id": 8}
+{"abstract_id": "25653199", "label": "methods", "text": "Measures were based on self-reports .", "sentence_id": 9}
+{"abstract_id": "25653199", "label": "results", "text": "All conditions showed reductions in drinking behavior and willingness to drink , and increased intentions to reduce drinking .", "sentence_id": 10}
+{"abstract_id": "25653199", "label": "results", "text": "Prototype alteration ( B = -@ , P < @ ) and cue reminder usage ( B = -@ , P < @ ) were both more effective in reducing alcohol consumption than when these strategies were not provided .", "sentence_id": 11}
+{"abstract_id": "25653199", "label": "results", "text": "Combining the strategies did not produce a synergistic effect .", "sentence_id": 12}
+{"abstract_id": "25653199", "label": "results", "text": "No differences across conditions were found regarding intentions or willingness .", "sentence_id": 13}
+{"abstract_id": "25653199", "label": "conclusions", "text": "Although individuals ' awareness of their cue was reasonable , their reported alcohol consumption was nevertheless reduced .", "sentence_id": 14}
+{"abstract_id": "25653199", "label": "conclusions", "text": "Individuals appeared to distance their self-image from heavier drinking prototypes .", "sentence_id": 15}
+{"abstract_id": "25653199", "label": "conclusions", "text": "Thus , prototype alteration and cue reminder usage may be feasible and simple intervention strategies to promote reductions in alcohol consumption among adults , with an effect up to @ months .", "sentence_id": 16}
+{"abstract_id": "24604881", "label": "background", "text": "Evidence suggests depression increases hospital readmission risk .", "sentence_id": 0}
+{"abstract_id": "24604881", "label": "objective", "text": "Determine whether depressive symptoms are associated with unplanned readmission within @ days of discharge of general medical patients .", "sentence_id": 1}
+{"abstract_id": "24604881", "label": "methods", "text": "Secondary analysis of the Project Re-Engineered Discharge ( RED ) randomized controlled trials .", "sentence_id": 2}
+{"abstract_id": "24604881", "label": "methods", "text": "Urban academic safety-net hospital .", "sentence_id": 3}
+{"abstract_id": "24604881", "label": "methods", "text": "A total of @ hospitalized adult English-speaking patients .", "sentence_id": 4}
+{"abstract_id": "24604881", "label": "methods", "text": "The @-Item Patient Health Questionnaire ( PHQ-@ ) was used to screen patients for depressive symptoms .", "sentence_id": 5}
+{"abstract_id": "24604881", "label": "methods", "text": "Hospital readmission within @ days of discharge .", "sentence_id": 6}
+{"abstract_id": "24604881", "label": "methods", "text": "Poisson regression was used to control for confounding variables .", "sentence_id": 7}
+{"abstract_id": "24604881", "label": "results", "text": "There were @ ( @ % ) patients who screened positive for mild depressive symptoms ( @ PHQ-@ @ ) and @ ( @ % ) for moderate or severe depressive symptoms ( PHQ-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24604881", "label": "results", "text": "After controlling for confounders , a higher rate of readmission was observed in subjects with mild depressive symptoms compared to subjects with PHQ-@ < @ , incidence rate ratio ( IRR ) @ ( @ % confidence interval -LSB- CI -RSB- : @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "24604881", "label": "results", "text": "The adjusted IRR of readmission for those with moderate-to-severe symptoms was @ ( @ % CI : @-@ @ ) compared to those with no depression .", "sentence_id": 10}
+{"abstract_id": "24604881", "label": "conclusions", "text": "Screening positive for mild and moderate-to-severe depressive symptoms during a hospitalization on a general medical service is associated with an increased dose-dependent readmission rate within @ days of discharge in an urban , academic , safety-net hospital .", "sentence_id": 11}
+{"abstract_id": "24604881", "label": "conclusions", "text": "Further research is needed to determine whether treatments targeting the reduction of depressive symptoms reduce the risk of readmission .", "sentence_id": 12}
+{"abstract_id": "25688781", "label": "objective", "text": "Gaucher disease type @ is characterized by hepatosplenomegaly , anemia , thrombocytopenia , and skeletal disease .", "sentence_id": 0}
+{"abstract_id": "25688781", "label": "objective", "text": "A safe , effective oral therapy is needed .", "sentence_id": 1}
+{"abstract_id": "25688781", "label": "objective", "text": "To determine whether eliglustat , a novel oral substrate reduction therapy , safely reverses clinical manifestations in untreated adults with Gaucher disease type @ .", "sentence_id": 2}
+{"abstract_id": "25688781", "label": "methods", "text": "Phase @ , randomized , double-blind , placebo-controlled trial conducted at @ sites in @ countries from November @ to July @ among eligible patients with splenomegaly plus thrombocytopenia and/or anemia .", "sentence_id": 3}
+{"abstract_id": "25688781", "label": "methods", "text": "Of @ patients screened , @ were enrolled .", "sentence_id": 4}
+{"abstract_id": "25688781", "label": "methods", "text": "Patients were stratified by spleen volume and randomized @:@ to receive eliglustat ( @ or @ mg twice daily ; n = @ ) or placebo ( n = @ ) for @ months .", "sentence_id": 5}
+{"abstract_id": "25688781", "label": "methods", "text": "The primary efficacy end point was percentage change in spleen volume in multiples of normal from baseline to @ months ; secondary efficacy end points were change in hemoglobin level and percentage changes in liver volume and platelet count .", "sentence_id": 6}
+{"abstract_id": "25688781", "label": "results", "text": "All patients had baseline splenomegaly and thrombocytopenia ( mostly moderate or severe ) , most had mild or moderate hepatomegaly , and @ % had mild anemia .", "sentence_id": 7}
+{"abstract_id": "25688781", "label": "results", "text": "Least-square mean spleen volume decreased by @ % ( @ % CI , -@ % to -@ % ) in the eliglustat group ( from @ to @ multiples of normal ) vs an increase of @ % ( @ % CI , -@ % to @ % ) in the placebo group ( from @ to @ multiples of normal ) for an absolute treatment difference of -@ % ( @ % CI , -@ % to -@ % ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25688781", "label": "results", "text": "For the secondary end points , the least-square mean absolute differences between groups all favored eliglustat , with a @-g / dL increase in hemoglobin level ( @ % CI , @-@ @ g/dL ; P < @ ) , @ % decrease in liver volume ( @ % CI , -@ % to -@ % ; P = @ ) , and @ % increase in platelet count ( @ % CI , @ % -@ % ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25688781", "label": "results", "text": "No serious adverse events occurred .", "sentence_id": 10}
+{"abstract_id": "25688781", "label": "results", "text": "One patient in the eliglustat group withdrew ( non-treatment related ) ; @ of the @ patients transitioned to an open-label extension study .", "sentence_id": 11}
+{"abstract_id": "25688781", "label": "conclusions", "text": "Among previously untreated adults with Gaucher disease type @ , treatment with eliglustat compared with placebo for @ months resulted in significant improvements in spleen volume , hemoglobin level , liver volume , and platelet count .", "sentence_id": 12}
+{"abstract_id": "25688781", "label": "conclusions", "text": "The clinical significance of these findings is uncertain , and more definitive conclusions about clinical efficacy and utility will require comparison with the standard treatment of enzyme replacement therapy as well as longer-term follow-up .", "sentence_id": 13}
+{"abstract_id": "24848282", "label": "objective", "text": "To investigate urine excretion of nephrin in patients with proteinuric nephropathies associated with rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "24848282", "label": "methods", "text": "We enrolled in the study @ patients with seropositive RA and proteinuria , the control group ( @ persons ) was formed from healthy blood donors , the comparison group ( @ persons ) was formed from RA patients without proteinuria .", "sentence_id": 1}
+{"abstract_id": "24848282", "label": "methods", "text": "Kidney biopsy was performed in @ patients ( glomerulonephritis was diagnosed in @ patients , - amyloidosis in @ patients and tubulointerstitial nephritis in @ patients ) .", "sentence_id": 2}
+{"abstract_id": "24848282", "label": "results", "text": "Urine nephrin concentration in patients with RA and proteinuria was @ ( @ ; @ ) ng/ml and significantly differed in its levels both in controls - @ ( @ ; @ ) ng/ml ( p = @ ) and RA patients without proteinuria - @ ( @ ; @ ) ng / ml ( p = @ ) group .", "sentence_id": 3}
+{"abstract_id": "24848282", "label": "results", "text": "In RA patients with proteinuria , we found a positive correlation between urine nephrin and protein concentrations ( r = @ ; p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24848282", "label": "results", "text": "Urine nephrin levels in patients of the glomerulonephritis - @ ( @ ; @ ) and amyloidosis groups - @ ( @ ; @ ) ng/ml were higher than in the controls ( p = @ ; p = @ ) and in the group of patients without proteinuria ( p = @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24848282", "label": "results", "text": "In the patients with tubulointerstitial nephritis urine nephrin concentration did not differ significantly with the values in both the control and the RA patients without proteinuria groups .", "sentence_id": 6}
+{"abstract_id": "24848282", "label": "conclusions", "text": "According to our data , proteinuria in the overall cohort of patients with seropositive RA is associated with increased levels of urine nephrin excretion , the highest levels of nephrin excretion were registered in patients with glomerulonephritis and amyloidosis .", "sentence_id": 7}
+{"abstract_id": "25416496", "label": "background", "text": "Depression is one the most common mental disorders that can be seen all over the world .", "sentence_id": 0}
+{"abstract_id": "25416496", "label": "background", "text": "In traditional Persian medicine , some medicinal herbs are recommended for depression treatment .", "sentence_id": 1}
+{"abstract_id": "25416496", "label": "background", "text": "This study aimed to evaluate the effects of Cuscuta planiflora Ten .", "sentence_id": 2}
+{"abstract_id": "25416496", "label": "background", "text": "and Nepeta menthoides Boiss .", "sentence_id": 3}
+{"abstract_id": "25416496", "label": "background", "text": "& Buhse in patients with major depression .", "sentence_id": 4}
+{"abstract_id": "25416496", "label": "methods", "text": "This study is a randomized triple-blind controlled clinical trial conducted in the year @ in Shiraz University of Medical Sciences on patients with major depression .", "sentence_id": 5}
+{"abstract_id": "25416496", "label": "methods", "text": "Pharmaceutical capsules of Cuscuta planiflora ( @ mg ) and Nepeta menthoides ( @ mg ) were prepared by a pharmacist .", "sentence_id": 6}
+{"abstract_id": "25416496", "label": "methods", "text": "Patients were randomly assigned to @ groups : group A ( treated with Nepeta menthoides capsules and conventional drugs ) , group B ( treated with Cuscuta planiflora capsules and conventional drugs ) , and group C ( treated only with conventional drugs ) .", "sentence_id": 7}
+{"abstract_id": "25416496", "label": "methods", "text": "The study period was @ weeks and depression was measured before and after the study by Beck Depression Inventory and Hamilton Depression Inventory .", "sentence_id": 8}
+{"abstract_id": "25416496", "label": "methods", "text": "The data were analyzed by SPSS version @ and the P < @ was considered statistically significant .", "sentence_id": 9}
+{"abstract_id": "25416496", "label": "results", "text": "A total of @ subjects participated in this study , of whom @ % were females ( n = @ ) and @ % were males ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "25416496", "label": "results", "text": "The mean standard deviation of age of the participants was @ @ years .", "sentence_id": 11}
+{"abstract_id": "25416496", "label": "results", "text": "The majority of patients ( @ % , n = @ ) were married .", "sentence_id": 12}
+{"abstract_id": "25416496", "label": "results", "text": "There were @ patients ( @ % ) in group A , @ ( @ % ) in group B , and @ ( @ % ) in group C.", "sentence_id": 13}
+{"abstract_id": "25416496", "label": "results", "text": "There was a significant decrease in mean scores of Beck and Hamilton depression inventories in the @ groups after treatment ( P < @ ) ; moreover , there was more decrease in scores of the Beck and Hamilton depression inventories in groups A and B compared with group C after treatment ( P < @ ) .", "sentence_id": 14}
+{"abstract_id": "25416496", "label": "conclusions", "text": "Despite the paucity of the population under study , the findings showed that Cuscuta planiflora and Nepeta menthoides capsules could be effective , affordable herbal medicines with improved cost-benefit in treatment of major depression and it is worth designing further and more extensive studies to get to a more accurate conclusion .", "sentence_id": 15}
+{"abstract_id": "24667038", "label": "objective", "text": "To evaluate the effect of side-cut angle profile on corneal biomechanical properties after femtosecond laser in situ keratomileusis ( FS-LASIK ) .", "sentence_id": 0}
+{"abstract_id": "24667038", "label": "methods", "text": "Ninety-six myopic eyes of @ patients underwent FS-LASIK .", "sentence_id": 1}
+{"abstract_id": "24667038", "label": "methods", "text": "One eye of each patient was randomized to flap creation with a side-cut angle of @ .", "sentence_id": 2}
+{"abstract_id": "24667038", "label": "methods", "text": "The fellow eye flap side-cut angle was adjusted to @ .", "sentence_id": 3}
+{"abstract_id": "24667038", "label": "methods", "text": "Mean absolute error of flap diameter and mean change in Goldmann-correlated intra-ocular pressure ( IOPg ) , corneal-compensated IOP ( IOPcc ) , corneal hysteresis ( CH ) , corneal resistance factor ( CRF ) , p@ area , p@ area , p@ area @ and p@ area @ were compared between both groups .", "sentence_id": 4}
+{"abstract_id": "24667038", "label": "results", "text": "Overall , the mean IOPg and CRF showed significant reduction at the end of @ and @months , as well as between @ and @months postoperatively ( p@ @ ) .", "sentence_id": 5}
+{"abstract_id": "24667038", "label": "results", "text": "The mean IOPcc and CH showed significant reduction ( p < @ ) at the end of @months postoperatively .", "sentence_id": 6}
+{"abstract_id": "24667038", "label": "results", "text": "The parameters p@ area , p@ area , p@ area @ and p@ area @ changed significantly at the end of @ and @months postoperatively ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24667038", "label": "results", "text": "There was no significant difference between both groups with regards to the mean change of IOPg , IOPcc , CH , CRF , p@ area , and p@ area @ .", "sentence_id": 8}
+{"abstract_id": "24667038", "label": "results", "text": "In @ group , the mean absolute error in flap diameter was greater compared with @ group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24667038", "label": "conclusions", "text": "The stability of IOP and corneal biomechanical properties were not enhanced in FS-LASIK flaps with an inverted side-cut angle .", "sentence_id": 10}
+{"abstract_id": "24667038", "label": "conclusions", "text": "The size of corneal flap created with @ side-cut angle was more accurate compared with @ side-cut angle .", "sentence_id": 11}
+{"abstract_id": "25764643", "label": "objective", "text": "To study post-operative pain and blood loss after intraoperative periarticular injection with the multimodal drugs diclofenac , adrenaline , marcaine ( bupivacaine ) and morphine in total knee arthroplasty .", "sentence_id": 0}
+{"abstract_id": "25764643", "label": "methods", "text": "A prospective randomized controlled trial of knee osteoarthritis patients age more than @ years undergoing total knee arthroplasty at Maharat Nakhon Ratchasima hospital from January @ through June @ was performed .", "sentence_id": 1}
+{"abstract_id": "25764643", "label": "methods", "text": "A group receiving intra-operative periarticular injections was compared to a control group receiving no injections .", "sentence_id": 2}
+{"abstract_id": "25764643", "label": "methods", "text": "Half of a group of forty-two patients , @ males and @ females , average age @ years ( range @-@ years ) , were randomly assigned to receive the periarticular injection ( the injection group ) , the others to the control group .", "sentence_id": 3}
+{"abstract_id": "25764643", "label": "methods", "text": "Pain was measured by two methods : visual analog score at @ , @ , @ and @ hours post-operation and by patient controlled analgesia ( PCA ) measuring the daily amount of intravenous morphine used .", "sentence_id": 4}
+{"abstract_id": "25764643", "label": "methods", "text": "The amount of blood loss post operation ( in the redivac drain ) , degree of knee flexion , time to onset of assisted ambulation , length of hospital stay and any complications were also analyzed .", "sentence_id": 5}
+{"abstract_id": "25764643", "label": "results", "text": "The mean VAS at @ and @ hours post operation of the injection group were @ and @ , whereas the values for the control group were @ and @ , respectively ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25764643", "label": "results", "text": "Mean quantities of morphine used by PCA by the injection group during the first day was @ mg , significantly lower than the @ mg used by the control group .", "sentence_id": 7}
+{"abstract_id": "25764643", "label": "results", "text": "Average blood loss of the injection group at @ ml was also significantly below the @ ml of the control group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25764643", "label": "results", "text": "The degree of knee flexion , time to onset of assist ambulation , length of hospital stay and complications , however were not significantly different between the groups .", "sentence_id": 9}
+{"abstract_id": "25764643", "label": "conclusions", "text": "Multimodal drugs , periarticular injections consisting of diclofenac , adrenaline , Marcaine plus a patient controled anesthetic machine ( PCA ) with morphine can significantly reduce post-operative pain and blood loss in total knee arthroplasty without significant adverse effects .", "sentence_id": 10}
+{"abstract_id": "24861959", "label": "objective", "text": "Most primary care clinicians lack the skills and resources to offer effective lifestyle and medication ( L&M ) counseling to reduce coronary heart disease ( CHD ) risk .", "sentence_id": 0}
+{"abstract_id": "24861959", "label": "objective", "text": "Thus , effective and feasible CHD prevention programs are needed for typical practice settings .", "sentence_id": 1}
+{"abstract_id": "24861959", "label": "objective", "text": "To assess the effectiveness , acceptability , and cost-effectiveness of a combined L&M intervention to reduce CHD risk offered in counselor-delivered and web-based formats .", "sentence_id": 2}
+{"abstract_id": "24861959", "label": "methods", "text": "A comparative effectiveness trial in @ diverse family medicine practices in North Carolina .", "sentence_id": 3}
+{"abstract_id": "24861959", "label": "methods", "text": "Participants were established patients , aged @ to @ years , with no known cardiovascular disease , and at moderate to high risk for CHD ( @-year Framingham Risk Score -LSB- FRS -RSB- , @ % ) .", "sentence_id": 4}
+{"abstract_id": "24861959", "label": "methods", "text": "Participants were randomized to counselor-delivered or web-based format , each including @ intensive and @ maintenance sessions .", "sentence_id": 5}
+{"abstract_id": "24861959", "label": "methods", "text": "After randomization , both formats used a web-based decision aid showing potential CHD risk reduction associated with L&M risk-reducing strategies .", "sentence_id": 6}
+{"abstract_id": "24861959", "label": "methods", "text": "Participants chose the risk-reducing strategies they wished to follow .", "sentence_id": 7}
+{"abstract_id": "24861959", "label": "methods", "text": "The primary outcome was within-group change in FRS at @-month follow-up .", "sentence_id": 8}
+{"abstract_id": "24861959", "label": "methods", "text": "Other measures included standardized assessments of blood pressure , blood lipid levels , lifestyle behaviors , and medication adherence .", "sentence_id": 9}
+{"abstract_id": "24861959", "label": "methods", "text": "Acceptability and cost-effectiveness were also assessed .", "sentence_id": 10}
+{"abstract_id": "24861959", "label": "methods", "text": "Outcomes were assessed at @ and @ months .", "sentence_id": 11}
+{"abstract_id": "24861959", "label": "results", "text": "Of @ screened patients , @ were randomized ( @ counselor ; @ web ) : mean age , @ years ; @ % African American ; and mean FRS , @ % .", "sentence_id": 12}
+{"abstract_id": "24861959", "label": "results", "text": "Follow-up at @ and @ months included @ % and @ % of the randomized participants , respectively .", "sentence_id": 13}
+{"abstract_id": "24861959", "label": "results", "text": "There was a sustained reduction in FRS at both @ months ( primary outcome ) and @ months for both counselor-based ( -@ % -LSB- @ % CI , -@ % to -@ % -RSB- and -@ % -LSB- @ % CI , -@ % to -@ % -RSB- , respectively ) and web-based groups ( -@ % -LSB- @ % CI , -@ % to -@ % -RSB- and -@ % -LSB- @ % CI , -@ % to -@ % -RSB- respectively ) .", "sentence_id": 14}
+{"abstract_id": "24861959", "label": "results", "text": "At @ months , the adjusted difference in FRS between groups was -@ % ( @ % CI , -@ % to -@ % ) ( P = @ ) , and at @ months , it was -@ % ( @ % CI , -@ % to @ % ) ( P = @ ) .", "sentence_id": 15}
+{"abstract_id": "24861959", "label": "results", "text": "The @-month costs from the payer perspective were $ @ and $ @ per person for the counselor - and web-based interventions , respectively .", "sentence_id": 16}
+{"abstract_id": "24861959", "label": "conclusions", "text": "Both intervention formats reduced CHD risk through @-month follow-up .", "sentence_id": 17}
+{"abstract_id": "24861959", "label": "conclusions", "text": "The web format was less expensive .", "sentence_id": 18}
+{"abstract_id": "25650503", "label": "objective", "text": "This randomized , double-blind @ week study compared the efficacy and tolerability of fixed-dose treatment with vortioxetine ( @mg/day ) and venlafaxine extended release ( XR ) ( @mg/day ) in major depressive disorder ( MDD ) patients .", "sentence_id": 0}
+{"abstract_id": "25650503", "label": "methods", "text": "Patients aged @-@ years with a primary diagnosis of recurrent MDD , a Montgomery-sberg Depression Rating Scale ( MADRS ) total score @ and a Clinical Global Impression-Severity ( CGI-S ) score @ were randomized ( @:@ ) to treatment with either vortioxetine or venlafaxine XR .", "sentence_id": 1}
+{"abstract_id": "25650503", "label": "methods", "text": "The primary endpoint was change from baseline to Week @ in MADRS total score ( analysis of covariance -LSB- ANCOVA -RSB- , full-analysis set -LSB- FAS -RSB- , last observation carried forward -LSB- LOCF -RSB- ) , using a non-inferiority margin of +@ points .", "sentence_id": 2}
+{"abstract_id": "25650503", "label": "methods", "text": "Pre-specified secondary endpoints included MADRS response and remission rates , anxiety symptoms ( HAM-A ) , CGI , overall functioning ( SDS ) , and health-related quality of life ( Q-LES-Q ) .", "sentence_id": 3}
+{"abstract_id": "25650503", "label": "background", "text": "This study ( SOLUTION ) has the www.ClinicalTrials.gov identifier : NCT@ .", "sentence_id": 4}
+{"abstract_id": "25650503", "label": "results", "text": "On the primary efficacy endpoint at Week @ , non-inferiority was established with a difference of -@ MADRS points in favor of vortioxetine ( @ % CI : -@ to @ ) .", "sentence_id": 5}
+{"abstract_id": "25650503", "label": "results", "text": "The MADRS total score decreased ( improved ) from @ at baseline to @ ( vortioxetine : n = @ ) and from @ to @ ( venlafaxine XR : n = @ ) ( FAS , LOCF ) .", "sentence_id": 6}
+{"abstract_id": "25650503", "label": "results", "text": "At Week @ , the HAM-A and SDS total scores , CGI and Q-LES-Q scores , and response and remission rates demonstrated similar improvement for vortioxetine and venlafaxine XR , with remission rates ( MADRS @ ) of @ % ( vortioxetine ) versus @ % ( venlafaxine XR ) ( LOCF ) .", "sentence_id": 7}
+{"abstract_id": "25650503", "label": "results", "text": "Fewer vortioxetine than venlafaxine XR patients withdrew for any reason ( @ % versus @ % ) or for adverse events ( @ % versus @ % ) .", "sentence_id": 8}
+{"abstract_id": "25650503", "label": "results", "text": "The most frequent adverse events ( @ % ) for both treatments were nausea , dizziness , headache , and dry mouth .", "sentence_id": 9}
+{"abstract_id": "25650503", "label": "results", "text": "In addition , accidental overdose , decreased appetite , constipation and insomnia were reported by ( @ % ) of patients treated with venlafaxine XR .", "sentence_id": 10}
+{"abstract_id": "25650503", "label": "conclusions", "text": "The inclusion and exclusion criteria may limit the generalizability of the study .", "sentence_id": 11}
+{"abstract_id": "25650503", "label": "conclusions", "text": "Since patients with a history of lack of response to venlafaxine XR were excluded from this study , there is a selection bias in favor of venlafaxine XR .", "sentence_id": 12}
+{"abstract_id": "25650503", "label": "conclusions", "text": "Vortioxetine was at least as efficacious as venlafaxine XR and was safe and better tolerated than venlafaxine XR .", "sentence_id": 13}
+{"abstract_id": "24733807", "label": "objective", "text": "Empiric antibiotic monotherapy is considered the standard of treatment for febrile neutropenic patients with cancer , but this approach may be inadequate because of the increasing prevalence of infections caused by multidrug resistant ( MDR ) bacteria .", "sentence_id": 0}
+{"abstract_id": "24733807", "label": "methods", "text": "In this multicenter , open-label , randomized , superiority trial , adult , febrile , high-risk neutropenic patients ( FhrNPs ) with hematologic malignancies were randomly assigned to receive piperacillin/tazobactam ( @ g intravenously every @ hours ) with or without tigecycline ( @ mg intravenously every @ hours ; loading dose @ mg ) .", "sentence_id": 1}
+{"abstract_id": "24733807", "label": "methods", "text": "The primary end point was resolution of febrile episode without modifications of the initial allocated treatment .", "sentence_id": 2}
+{"abstract_id": "24733807", "label": "results", "text": "Three hundred ninety FhrNPs were enrolled ( combination/monotherapy , @/@ ) and were included in the intention-to-treat analysis ( ITTA ) .", "sentence_id": 3}
+{"abstract_id": "24733807", "label": "results", "text": "The ITTA revealed a successful outcome in @ % v @ % of patients who had received combination therapy and monotherapy , respectively ( @/@ v @/@ ; absolute difference in risk ( adr ) , @ % ; @ % CI , @ % to @ % ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24733807", "label": "results", "text": "The combination regimen proved better than monotherapy in bacteremias ( adr , @ % ; @ % CI , @ % to @ % ; P < @ ) and in clinically documented infections ( adr , @ % ; @ % CI , @ % to @ % ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24733807", "label": "results", "text": "Mortality and number of adverse effects were limited and similar in the two groups .", "sentence_id": 6}
+{"abstract_id": "24733807", "label": "conclusions", "text": "The combination of piperacillin/tazobactam and tigecycline is safe , well tolerated , and more effective than piperacillin/tazobactam alone in febrile , high-risk , neutropenic hematologic patients with cancer .", "sentence_id": 7}
+{"abstract_id": "24733807", "label": "conclusions", "text": "In epidemiologic settings characterized by a high prevalence of infections because of MDR microorganisms , this combination could be considered as one of the first-line empiric antibiotic therapies .", "sentence_id": 8}
+{"abstract_id": "24899755", "label": "objective", "text": "To compare pregabalin versus placebo and pramipexole for reducing restless legs syndrome ( RLS ) - related sleep disturbance .", "sentence_id": 0}
+{"abstract_id": "24899755", "label": "methods", "text": "Randomized , double-blinded , crossover trial .", "sentence_id": 1}
+{"abstract_id": "24899755", "label": "methods", "text": "Twenty-three US sleep centers .", "sentence_id": 2}
+{"abstract_id": "24899755", "label": "methods", "text": "Eighty-five individuals with moderate to severe idiopathic RLS and associated sleep disturbance .", "sentence_id": 3}
+{"abstract_id": "24899755", "label": "methods", "text": "Participants were randomized across @ treatment sequences comprising three @-week periods on pregabalin @ mg/day ( n = @ ) , pramipexole @ mg/day ( n = @ ) , or placebo ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24899755", "label": "results", "text": "Polysomnography was conducted over @ nights at the end of each period .", "sentence_id": 5}
+{"abstract_id": "24899755", "label": "results", "text": "Primary ( wake after sleep onset -LSB- WASO -RSB- , pregabalin vs placebo ) and key secondary endpoints were analyzed for statistical significance , with descriptive statistics for other endpoints .", "sentence_id": 6}
+{"abstract_id": "24899755", "label": "results", "text": "Pregabalin improved sleep maintenance , demonstrated by reductions in WASO ( -@ min vs placebo -LSB- P < @ -RSB- ; -@ vs pramipexole ) and number of awakenings after sleep onset ( -@ vs placebo ; -@ vs pramipexole -LSB- P < @ -RSB- ) by polysomnography , and an increase in subjective total sleep time ( @ min vs placebo -LSB- P < @ -RSB- ; @ vs pramipexole ) .", "sentence_id": 7}
+{"abstract_id": "24899755", "label": "results", "text": "Pregabalin also increased slow wave sleep duration ( @ min vs placebo ; @ vs pramipexole -LSB- P < @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "24899755", "label": "results", "text": "Reduction in periodic limb movement arousal index ( PLMAI ) with pregabalin was similar to pramipexole and greater than placebo ( -@ PLMA/h -LSB- P < @ -RSB- ) , although reduction in total PLM in sleep was less than for pramipexole .", "sentence_id": 9}
+{"abstract_id": "24899755", "label": "conclusions", "text": "This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole .", "sentence_id": 10}
+{"abstract_id": "24899755", "label": "conclusions", "text": "Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole .", "sentence_id": 11}
+{"abstract_id": "25042266", "label": "objective", "text": "Limited data exist on radial access in carotid artery stenting .", "sentence_id": 0}
+{"abstract_id": "25042266", "label": "objective", "text": "This multicentre prospective randomised study was performed to compare the outcome and complication rates of transradial and transfemoral carotid artery stenting .", "sentence_id": 1}
+{"abstract_id": "25042266", "label": "results", "text": "The clinical and angiographic data of @ consecutive patients with high risk for carotid endarterectomy , treated between @ and @ by carotid stenting with cerebral protection , were evaluated .", "sentence_id": 2}
+{"abstract_id": "25042266", "label": "results", "text": "Patients were randomised to transradial ( n = @ ) or transfemoral ( n = @ ) groups and several parameters were evaluated .", "sentence_id": 3}
+{"abstract_id": "25042266", "label": "results", "text": "Primary combined endpoint : major adverse cardiac and cerebral events , rate of access-site complications .", "sentence_id": 4}
+{"abstract_id": "25042266", "label": "results", "text": "Secondary endpoints : angiographic outcome of the procedure , fluoroscopy time and X-ray dose , procedural time , crossover rate to another puncture site and hospitalisation in days .", "sentence_id": 5}
+{"abstract_id": "25042266", "label": "results", "text": "Procedural success was achieved in all @ patients ( @ % ) , the crossover rate was @ % in the TR and @ % in the TF group ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25042266", "label": "results", "text": "A major access-site complication was encountered in one patient ( @ % ) in the TR group and in one patient ( @ % ) in the TF group ( p = ns ) .", "sentence_id": 7}
+{"abstract_id": "25042266", "label": "results", "text": "The incidence of major adverse cardiac and cerebral events was @ % in the TR and @ % in the TF group ( p = ns ) .", "sentence_id": 8}
+{"abstract_id": "25042266", "label": "results", "text": "Procedure time ( @,@ -LSB- @,@-@ ,@ -RSB- vs. @,@ -LSB- @,@-@ ,@ -RSB- sec , p = ns ) and fluoroscopy time ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- sec , p = ns ) were not significantly different , but the radiation dose was significantly higher in the TR group ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- Gy * cm@ , p < @ ) by per-protocol analysis .", "sentence_id": 9}
+{"abstract_id": "25042266", "label": "results", "text": "Hospitalisation days were significantly lower in the TR group ( @ vs. @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25042266", "label": "results", "text": "By intention-to-treat analysis there was a significantly higher radiation dose in the TR group ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- , p < @ ) , but no difference in major events ( @ vs. @ , p = ns ) and length of hospitalisation in days ( @ vs. @ , p = ns ) .", "sentence_id": 11}
+{"abstract_id": "25042266", "label": "conclusions", "text": "The transradial approach for carotid artery stenting is safe and efficacious ; however , the crossover rate is higher with transradial access .", "sentence_id": 12}
+{"abstract_id": "25042266", "label": "conclusions", "text": "There are no differences in the total procedure duration and fluoroscopy time between the two approaches but the radiation dose is significantly higher in the radial group , and the hospitalisation is shorter with the use of transradial access by per-protocol analysis .", "sentence_id": 13}
+{"abstract_id": "25042266", "label": "conclusions", "text": "By evaluating the patient data according to intention-to-treat analysis we found no difference in major adverse events and hospitalisation .", "sentence_id": 14}
+{"abstract_id": "25042266", "label": "conclusions", "text": "In both groups , vascular complications rarely occurred .", "sentence_id": 15}
+{"abstract_id": "24620920", "label": "objective", "text": "Here , we evaluated the safety and immunogenicity of hepatitis B virus ( HBV ) DNA vaccine , HB-@ , in mice and Korean patients with chronic hepatitis B ( CHB ) undergoing adefovir dipivoxil ( ADV ) treatment .", "sentence_id": 0}
+{"abstract_id": "24620920", "label": "methods", "text": "For animal study , mice ( BALB/c or HBV transgenic ) were immunized with mHB-@ , and T-cell and antibody responses were evaluated .", "sentence_id": 1}
+{"abstract_id": "24620920", "label": "methods", "text": "For clinical study , @ patients randomly received either ADV alone or ADV in combination with HB-@ .", "sentence_id": 2}
+{"abstract_id": "24620920", "label": "methods", "text": "Liver function tests , serum HBV DNA levels and the presence of HBeAg/anti-HBe were analysed .", "sentence_id": 3}
+{"abstract_id": "24620920", "label": "methods", "text": "T-cell responses were estimated by ELISPOT and FACS analysis .", "sentence_id": 4}
+{"abstract_id": "24620920", "label": "results", "text": "mHB-@ induced higher T-cell and antibody responses than mHB-@ in mice .", "sentence_id": 5}
+{"abstract_id": "24620920", "label": "results", "text": "No adverse effects were observed by HB-@ cotreated with ADV. HBV-specific T-cell responses were induced in a portion of patients in medium to high dose of HB-@ .", "sentence_id": 6}
+{"abstract_id": "24620920", "label": "results", "text": "Interestingly , HB-@ exhibited positive effects on ALT normalization and maintenance of HBeAg seroconversion .", "sentence_id": 7}
+{"abstract_id": "24620920", "label": "results", "text": "One patient , who received high dose of HB-@ exhibited HBeAg seroconversion during vaccination , which correlated with vaccine-induced T-cell responses without ALT elevation .", "sentence_id": 8}
+{"abstract_id": "24620920", "label": "conclusions", "text": "HB-@ was safe and tolerable in CHB patients .", "sentence_id": 9}
+{"abstract_id": "24620920", "label": "conclusions", "text": "In contrast to results in animal models , HB-@ in Korean patients exhibited weaker capability of inducing HBV-specific T-cell responses and HBeAg seroconversion than HB-@ in Caucasian patients .", "sentence_id": 10}
+{"abstract_id": "24620920", "label": "conclusions", "text": "As Asian patients , who are generally infected via vertical transmission , appeared to have higher level of immune tolerance than Caucasian , novel approaches for breaking immune tolerance rather than enhancing immunogenicity may be more urgently demanded to develop effective therapeutic HBV DNA vaccines .", "sentence_id": 11}
+{"abstract_id": "25127208", "label": "background", "text": "We assessed the efficacy , safety , and tolerability of ponesimod , an oral , selective , reversible modulator of sphingosine @-phosphate receptor @ , in patients with moderate to severe chronic plaque psoriasis .", "sentence_id": 0}
+{"abstract_id": "25127208", "label": "methods", "text": "Between Sept @ , @ , and Oct @ , @ , patients with psoriasis area and severity index ( PASI ) scores higher than @ were enrolled into this multicentre double-blind , phase @ study .", "sentence_id": 1}
+{"abstract_id": "25127208", "label": "methods", "text": "They received @ mg or @ mg ponesimod or placebo once daily for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25127208", "label": "methods", "text": "Those with at least @ % reduction in PASI score at @ weeks and who were receiving ponesimod were rerandomised to receive maintenance ponesimod therapy or placebo until week @ .", "sentence_id": 3}
+{"abstract_id": "25127208", "label": "methods", "text": "The primary endpoint was reduction in PASI score from baseline of at least @ % ( PASI@ ) at week @ .", "sentence_id": 4}
+{"abstract_id": "25127208", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 5}
+{"abstract_id": "25127208", "label": "results", "text": "Of @ patients initially randomised ( @ mg ponesimod n = @ , @ mg ponesimod n = @ , and placebo n = @ ) PASI@ was achieved at week @ in @ ( @ % ) , @ ( @ % ) , and nine ( @ % ) , respectively .", "sentence_id": 6}
+{"abstract_id": "25127208", "label": "results", "text": "The treatment effect was significant for the two ponesimod doses ( both p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25127208", "label": "results", "text": "Of @ patients who entered the maintenance period , PASI@ was achieved by week @ in @ ( @ % ) of @ who continued on @ mg ponesimod and @ ( @ % ) of @ on @ mg ponesimod , and in @ ( @ % ) of @ who swapped from @ mg to placebo and @ ( @ % ) of @ from @ mg to placebo .", "sentence_id": 8}
+{"abstract_id": "25127208", "label": "results", "text": "Ponesimod was associated with dyspnoea , raised liver enzyme concentrations , and dizziness .", "sentence_id": 9}
+{"abstract_id": "25127208", "label": "conclusions", "text": "Significant clinical benefit was seen at week @ that increased with maintenance therapy .", "sentence_id": 10}
+{"abstract_id": "24889819", "label": "objective", "text": "We have previously reported excellent cecal intubation rates using a short double-balloon endoscope in patients with a history of incomplete colonoscopy .", "sentence_id": 0}
+{"abstract_id": "24889819", "label": "objective", "text": "However , data on the endoscopic treatment of colorectal tumors using a double-balloon endoscope are limited .", "sentence_id": 1}
+{"abstract_id": "24889819", "label": "objective", "text": "The aim of the present study was to evaluate the efficacy and safety of endoscopic intervention of colorectal tumors using a short double-balloon endoscope .", "sentence_id": 2}
+{"abstract_id": "24889819", "label": "methods", "text": "We analyzed data from a multicenter , prospective study on @ patients ( @ men , median age @ years ) who underwent total colonoscopy after incomplete colonoscopy to assess the characteristics of colorectal tumors , endoscopic interventions , and complications .", "sentence_id": 3}
+{"abstract_id": "24889819", "label": "results", "text": "In all , @ colorectal tumors were detected in @ patients ; @ of the tumors were adenomas ( @ advanced adenomas ) and two each were intramucosal and advanced cancers .", "sentence_id": 4}
+{"abstract_id": "24889819", "label": "results", "text": "Locations of the lesions were eight in the cecum , @ in the ascending colon , @ in the transverse colon , @ in the descending colon , @ in the sigmoid colon , five in the rectosigmoid and six in the rectum .", "sentence_id": 5}
+{"abstract_id": "24889819", "label": "results", "text": "Average tumor diameter was @ mm .", "sentence_id": 6}
+{"abstract_id": "24889819", "label": "results", "text": "Fifty-nine polypectomies , @ endoscopic mucosal resections , four hot biopsies , and six cold biopsies were done .", "sentence_id": 7}
+{"abstract_id": "24889819", "label": "results", "text": "All endoscopic interventions were successfully completed and no complications were noted .", "sentence_id": 8}
+{"abstract_id": "24889819", "label": "results", "text": "Two advanced cancers were located in the ascending colon and only a double-balloon endoscope could reach them to take a biopsy sample .", "sentence_id": 9}
+{"abstract_id": "24889819", "label": "conclusions", "text": "Double-balloon endoscopy is effective and safe for endoscopic intervention of colorectal tumors , irrespective of the location , in patients after incomplete colonoscopy .", "sentence_id": 10}
+{"abstract_id": "25982133", "label": "background", "text": "The commonality between chronic conditions that are treated with low-dose ketamine , such as specific chronic pain conditions , depression , and post-traumatic stress disorder , can be found in relation to the stress system , particularly the hypothalamus-pituitary-adrenal axis .", "sentence_id": 0}
+{"abstract_id": "25982133", "label": "background", "text": "In this study we assess the effect of ketamine on the stress system by measuring plasma and saliva cortisol production during and following exposure to low-dose ketamine .", "sentence_id": 1}
+{"abstract_id": "25982133", "label": "methods", "text": "In a double-blind , randomized , placebo-controlled study , the influence of subanaesthetic ketamine ( @ mg kg ( -@ ) h ( -@ ) for @ h , followed by @ mg kg ( -@ ) h ( -@ ) for another hour ) was studied with repeated plasma and saliva cortisol samples in @ healthy male volunteers .", "sentence_id": 2}
+{"abstract_id": "25982133", "label": "methods", "text": "A pharmacokinetic-pharmacodynamic model was used to describe the circadian rhythm-dependent ketamine-induced production of cortisol .", "sentence_id": 3}
+{"abstract_id": "25982133", "label": "results", "text": "The endogenous mean baseline cortisol production was @ ( SE @ ) nM min ( -@ ) .", "sentence_id": 4}
+{"abstract_id": "25982133", "label": "results", "text": "Consistent with the circadian rhythm , cortisol production decayed by @ nM min ( -@ ) h ( -@ ) .", "sentence_id": 5}
+{"abstract_id": "25982133", "label": "results", "text": "Ketamine doubled the cortisol production at a concentration of @ ( SE @ ) ng ml ( -@ ) .", "sentence_id": 6}
+{"abstract_id": "25982133", "label": "results", "text": "The salivary cortisol concentration closely mirrored the plasma concentration and was exponentially related to the plasma concentration with , at @ ng ml ( -@ ) ketamine , a saliva : plasma ratio of @ ( se @ ) .", "sentence_id": 7}
+{"abstract_id": "25982133", "label": "conclusions", "text": "Ketamine has an appreciable effect on cortisol production .", "sentence_id": 8}
+{"abstract_id": "25982133", "label": "conclusions", "text": "This may impact on critical physiological and psychological functions .", "sentence_id": 9}
+{"abstract_id": "24630956", "label": "objective", "text": "The purpose of this randomized controlled study was to compare knee stability , kneeling pain , harvest site pain , sensitivity loss , and subjective clinical outcome after primary anterior cruciate ligament ( ACL ) reconstruction with either bone-patellar tendon-bone ( BPTB ) or quadriceps tendon-bone ( QTB ) autografts in a noninferiority study design .", "sentence_id": 0}
+{"abstract_id": "24630956", "label": "methods", "text": "From @ to @ , a total of @ patients were included in the present study .", "sentence_id": 1}
+{"abstract_id": "24630956", "label": "methods", "text": "Inclusion criteria were isolated ACL injuries in adults .", "sentence_id": 2}
+{"abstract_id": "24630956", "label": "methods", "text": "Twenty-five patients were randomized to BPTB grafts and @ to QTB grafts .", "sentence_id": 3}
+{"abstract_id": "24630956", "label": "methods", "text": "An independent examiner performed follow-up evaluations @ and @ years postoperatively .", "sentence_id": 4}
+{"abstract_id": "24630956", "label": "methods", "text": "Anteroposterior knee laxity was measured with a KT-@ arthrometer ( MEDmetric , San Diego , CA ) .", "sentence_id": 5}
+{"abstract_id": "24630956", "label": "methods", "text": "Anterior knee pain was assessed clinically and by knee-walking ability .", "sentence_id": 6}
+{"abstract_id": "24630956", "label": "methods", "text": "Knee Injury and Osteoarthritis Outcome Score ( KOOS ) and subjective International Knee Documentation Committee ( IKDC ) score were used for patient-evaluated outcome .", "sentence_id": 7}
+{"abstract_id": "24630956", "label": "results", "text": "Anterior knee laxity was equal between the @ groups with KT-@ values of @ @ mm and @ @ mm standard deviation ( SD ) at follow-up in QTB and BPTB groups , respectively ( P = @ ) , whereas positive pivot shift test results were seen less frequently ( @ % compared with @ % , respectively ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24630956", "label": "results", "text": "Anterior kneeling pain , evaluated by the knee walking ability test , was significantly less in the QTB group , with only @ % of patients grading knee walking as difficult or impossible compared with @ % in the BPTB group .", "sentence_id": 9}
+{"abstract_id": "24630956", "label": "results", "text": "At @ and @ years ' follow-up , there was no difference between the @ groups in subjective patient-evaluated outcome .", "sentence_id": 10}
+{"abstract_id": "24630956", "label": "results", "text": "The IKDC score was @ @ patients and @ @ SD at @-year follow-up in QTB and BPTB groups , respectively ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24630956", "label": "results", "text": "At @ years , @ patients were lost to follow-up , resulting in @ in the BPTB group and @ in the QTB group .", "sentence_id": 12}
+{"abstract_id": "24630956", "label": "conclusions", "text": "The use of the QTB graft results in less kneeling pain , graft site pain , and sensitivity loss than seen with BPTB grafts ; however , similar anterior knee stability and subjective outcomes are seen .", "sentence_id": 13}
+{"abstract_id": "24630956", "label": "conclusions", "text": "The results of this study show that QTB is a viable option for ACL reconstruction .", "sentence_id": 14}
+{"abstract_id": "24630956", "label": "methods", "text": "Level II , randomized controlled clinical trial .", "sentence_id": 15}
+{"abstract_id": "25362221", "label": "background", "text": "This study was aimed to investigate the effects of raloxifene on intact parathyroid hormone ( PTH ) level and bone mineral density ( BMD ) for @ months in women on hemodialysis and women with chronic kidney disease stage @ not dependent on dialysis to determine its effect on secondary hyperparathyroidism and osteoporosis .", "sentence_id": 0}
+{"abstract_id": "25362221", "label": "methods", "text": "Fifty-one women on hemodialysis and @ with chronic kidney disease stage @ were randomly assigned to receive oral raloxifene , @ mg/d , or placebo for @ months .", "sentence_id": 1}
+{"abstract_id": "25362221", "label": "methods", "text": "Baseline blood determinations and BMD were done and repeated after @ months .", "sentence_id": 2}
+{"abstract_id": "25362221", "label": "methods", "text": "Serum levels of total calcium , phosphorus , alkaline phosphatase , and intact PTH were measured .", "sentence_id": 3}
+{"abstract_id": "25362221", "label": "results", "text": "Serum levels of intact PTH significantly decreased in both groups , and there was no difference between the two groups after @ months ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25362221", "label": "results", "text": "Serum phosphorus levels also decreased by @ % in the two groups .", "sentence_id": 5}
+{"abstract_id": "25362221", "label": "results", "text": "After @ months of treatment , the BMD of the lumbar spine and femural neck decreased by @ % in the control group , while an increase in BMD was observed in the raloxifene group , with an average increase in both BMDs of the lumbar spine and the femural neck by @ % ( significant in the lumbar spine ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25362221", "label": "conclusions", "text": "Raloxifene has proven to be an effective medication in terms of improving BMD , with no adverse effects .", "sentence_id": 7}
+{"abstract_id": "25362221", "label": "conclusions", "text": "However , it had no effect on controlling hyperparathyroidism in our patients .", "sentence_id": 8}
+{"abstract_id": "25362221", "label": "conclusions", "text": "Long-term studies should be done to investigate the effects of raloxifene in chronic kidney disease and dialysis patients .", "sentence_id": 9}
+{"abstract_id": "24864639", "label": "objective", "text": "To determine whether the addition of @ mg dexamethasone to axillary brachial plexus block would prolong the duration of sensory and motor block in patients undergoing hand and forearm surgery .", "sentence_id": 0}
+{"abstract_id": "24864639", "label": "methods", "text": "The prospective , randomised , double-blinded study was conducted at the Eskisehir Osmangazi University Medical School , Turkey , from October @ to December @ .", "sentence_id": 1}
+{"abstract_id": "24864639", "label": "methods", "text": "It comprised @ American Society of Anaesthesiologists grade I and II patients under elective surgery of the hand and forearm .", "sentence_id": 2}
+{"abstract_id": "24864639", "label": "methods", "text": "The patients were randomly divided into @ groups : @ mg/kg of @ % prilocaine was applied to Group @ ; @ mg/kg of @ % prilocaine +@ mg of dexamethasone ( @ ml ) was applied to Group @ ; and @ mg/kg @ % levobupivacaine was applied to Group @ .", "sentence_id": 3}
+{"abstract_id": "24864639", "label": "methods", "text": "Sensory and motor block onset time as well as the duration of motor and sensory block of those were monitored and recorded .", "sentence_id": 4}
+{"abstract_id": "24864639", "label": "methods", "text": "SPSS @ was used for statistical analysis .", "sentence_id": 5}
+{"abstract_id": "24864639", "label": "results", "text": "Of the @ patients , @ ( @ % ) were men and @ ( @ % ) were women .", "sentence_id": 6}
+{"abstract_id": "24864639", "label": "results", "text": "There was no significant difference among the groups in terms of demographic data .", "sentence_id": 7}
+{"abstract_id": "24864639", "label": "results", "text": "Based on the duration of motor and sensory block , similar periods of time in Group @ and Group @ were noted , whereas this period was statistically different and significantly longer in Group @ ( p < or = @ ) .", "sentence_id": 8}
+{"abstract_id": "24864639", "label": "results", "text": "There were no complications encountered .", "sentence_id": 9}
+{"abstract_id": "24864639", "label": "conclusions", "text": "The addition of dexamethasone to prilocaine prolonged the duration of sensory and motor block .", "sentence_id": 10}
+{"abstract_id": "24864639", "label": "conclusions", "text": "It could be used as an effective adjuvant agent .", "sentence_id": 11}
+{"abstract_id": "24864639", "label": "conclusions", "text": "Levobupivacain could be a more appropriate local anaesthetic in postoperative analgesia and prolonged surgical procedures .", "sentence_id": 12}
+{"abstract_id": "24233244", "label": "objective", "text": "To investigate the effect of @ weeks of aerobic training performed at two different intensities on nitric oxide ( tNOx ) availability and iNOS/nNOS expression , oxidative stress ( OS ) and inflammation in obese humans with or without type @ diabetes mellitus ( T@DM ) .", "sentence_id": 0}
+{"abstract_id": "24233244", "label": "methods", "text": "Twenty-five sedentary , obese ( BMI > @ kg/m@ ) males ( @ @ years ) ; @ controls versus @ T@DM were randomly allocated to four groups that exercised for @ min , three times per week either at low ( Fat-Max ; @-@ % VO ( @max ) ) or moderate ( T ( vent ) ; @-@ % VO ( @max ) ) intensity .", "sentence_id": 1}
+{"abstract_id": "24233244", "label": "methods", "text": "Before and after training , blood and muscle samples ( v. lateralis ) were collected .", "sentence_id": 2}
+{"abstract_id": "24233244", "label": "results", "text": "Baseline erythrocyte glutathione was lower ( @ @ vs. @ @ nmol/ml ) and plasma protein oxidative damage and IL-@ were higher in T@DM ( @ @ vs. @ @ nmol/ml ) .", "sentence_id": 3}
+{"abstract_id": "24233244", "label": "results", "text": "Plasma catalase increased in T@DM after T ( vent ) training ( from @ @ to @ @ nmol/min/ml ) .", "sentence_id": 4}
+{"abstract_id": "24233244", "label": "results", "text": "T@DM groups demonstrated evidence of oxidative damage in response to training ( elevated protein carbonyls ) .", "sentence_id": 5}
+{"abstract_id": "24233244", "label": "results", "text": "Baseline serum tNOx were higher in controls than T@DM ( @ @ vs. @ @ mol/l ) .", "sentence_id": 6}
+{"abstract_id": "24233244", "label": "results", "text": "Training at T ( vent ) increased muscle nNOS and tNOx in the control group only .", "sentence_id": 7}
+{"abstract_id": "24233244", "label": "results", "text": "Pre-training muscle nNOS was higher in controls than in T@DMs , while the opposite was found for iNOS .", "sentence_id": 8}
+{"abstract_id": "24233244", "label": "results", "text": "No differences were found after training for plasma inflammatory markers .", "sentence_id": 9}
+{"abstract_id": "24233244", "label": "conclusions", "text": "Exercise training did not change body composition or aerobic fitness , but improved OS markers , especially when performed at T ( vent ) .", "sentence_id": 10}
+{"abstract_id": "24233244", "label": "conclusions", "text": "Non-diabetics responded to T ( vent ) training by increasing muscle nNOS expression and tNOx levels in skeletal muscle while these parameters did not change in T@DM , perhaps due to higher insulin resistance ( unchanged after intervention ) .", "sentence_id": 11}
+{"abstract_id": "25112084", "label": "objective", "text": "To verify the efficacy of Jianpi-xingniao needling therapy on prevention and treatment of motion sickness .", "sentence_id": 0}
+{"abstract_id": "25112084", "label": "methods", "text": "Sixty volunteers of motion sickness were randomized into an acupuncture group and a delayed acupuncture group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25112084", "label": "methods", "text": "In the acupuncture group , acupuncture was given at Baihui ( GV @ ) , Sishencong ( EX-HN @ ) , Neiguan ( PC @ ) , Zusanli ( ST @ ) and Hegu ( LI @ ) .", "sentence_id": 2}
+{"abstract_id": "25112084", "label": "methods", "text": "The needles were retained for @ min .", "sentence_id": 3}
+{"abstract_id": "25112084", "label": "methods", "text": "The treatment was given twice a week and @ treatments were required .", "sentence_id": 4}
+{"abstract_id": "25112084", "label": "methods", "text": "In the delayed acupuncture group , acupuncture was postponed , meaning no acupuncture during observation stage .", "sentence_id": 5}
+{"abstract_id": "25112084", "label": "methods", "text": "Graybel scale was adopted to observe the score of symptoms and physical signs of the subjects of motion sickness before and after intervention .", "sentence_id": 6}
+{"abstract_id": "25112084", "label": "methods", "text": "The efficacy was compared between the two groups .", "sentence_id": 7}
+{"abstract_id": "25112084", "label": "results", "text": "Twenty-five cases in the acupuncture group and @ cases in the delayed acupuncture group were included in the statistical analysis .", "sentence_id": 8}
+{"abstract_id": "25112084", "label": "results", "text": "The score of symptoms and physical signs of motion sickness was reduced significantly after treatment in the acupuncture group as compared with that before treatment ( @ + / - @ vs @ + / - @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25112084", "label": "results", "text": "The score in the acupuncture group was lower apparently than that in the delayed acupuncture group ( @ + / - @ vs @ + / - @ , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25112084", "label": "results", "text": "The difference was not significant before and after treatment in the self-comparison of the delayed acupuncture group ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "25112084", "label": "results", "text": "The total effective rate was @ % ( @/@ ) in the acupuncture group , which was significantly better than @ % ( @/@ ) in the delayed acupuncture group ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25112084", "label": "conclusions", "text": "Jianpixingniao needling therapy relieves the symptoms of motion sickness in the patients and achieves a better clinical efficacy .", "sentence_id": 13}
+{"abstract_id": "25118967", "label": "background", "text": "Rapid HIV testing in high-risk populations can increase the number of persons who learn their HIV status and avoid spending clinic resources to locate persons identified as HIV infected .", "sentence_id": 0}
+{"abstract_id": "25118967", "label": "methods", "text": "We determined the cost to sexually transmitted disease ( STD ) clinics of point-of-care rapid HIV testing using data from @ public clinics that participated in a randomized trial of rapid testing with and without brief patient-centered risk reduction counseling in @ .", "sentence_id": 1}
+{"abstract_id": "25118967", "label": "methods", "text": "Costs included counselor and trainer time , supplies , and clinic overhead .", "sentence_id": 2}
+{"abstract_id": "25118967", "label": "methods", "text": "We applied national labor rates and test costs .", "sentence_id": 3}
+{"abstract_id": "25118967", "label": "methods", "text": "We calculated median clinic start-up costs and mean cost per patient tested , and projected incremental annual costs of implementing universal rapid HIV testing compared with current testing practices .", "sentence_id": 4}
+{"abstract_id": "25118967", "label": "results", "text": "Criteria for offering rapid HIV testing and methods for delivering nonrapid test results varied among clinics before the trial .", "sentence_id": 5}
+{"abstract_id": "25118967", "label": "results", "text": "Rapid HIV testing cost an average of US $ @/patient without brief risk reduction counseling and US $ @/patient with counseling in these @ clinics .", "sentence_id": 6}
+{"abstract_id": "25118967", "label": "results", "text": "Median start-up costs per clinic were US $ @ and US $ @,@ without and with counseling , respectively .", "sentence_id": 7}
+{"abstract_id": "25118967", "label": "results", "text": "Estimated incremental annual costs per clinic of implementing universal rapid HIV testing varied by whether or not brief counseling is conducted and by current clinic testing practices , ranging from a savings of US $ @,@ to a cost of US $ @,@ without counseling and a cost of US $ @,@ to US $ @,@ with counseling .", "sentence_id": 8}
+{"abstract_id": "25118967", "label": "conclusions", "text": "Universal rapid HIV testing in STD clinics with same-day results can be implemented at relatively low cost to STD clinics , if brief risk reduction counseling is not offered .", "sentence_id": 9}
+{"abstract_id": "25009161", "label": "background", "text": "The risk of persistent tardive dyskinesia ( TD ) was compared in patients with acute psychosis or agitation aged @ years or older who were treated with olanzapine ( OLZ ) or conventional antipsychotic ( CNV ) drug therapy .", "sentence_id": 0}
+{"abstract_id": "25009161", "label": "methods", "text": "Patients without TD were randomized to treatment with OLZ ( @-@ mg/d ; n = @ ) or CNV ( dosed per label ; n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25009161", "label": "methods", "text": "Following a @-week drug tapering/initiation period , patients without TD were treated with OLZ or CNV for up to @ year .", "sentence_id": 2}
+{"abstract_id": "25009161", "label": "methods", "text": "The a priori defined primary outcome end point was persistent TD defined as Abnormal Involuntary Movement Scale ( AIMS ) scores = @ on at least @ items or @ on at least @ item ( items @-@ ) lasting at least for @ month ( Criterion A ) .", "sentence_id": 3}
+{"abstract_id": "25009161", "label": "methods", "text": "Post hoc analyses assessed persistent TD meeting the criterion of moderate severity defined as AIMS score @ on at least @ item persisting for @ month ( Criterion B ) and probable TD defined as elevated AIMS scores ( Criterion A or B ) not persisting for @ month .", "sentence_id": 4}
+{"abstract_id": "25009161", "label": "methods", "text": "Treatment groups were compared using Kaplan-Meier curve with log-rank exact test .", "sentence_id": 5}
+{"abstract_id": "25009161", "label": "results", "text": "On average , patients were @ years of age ; the predominant diagnosis was dementia ( @ % in the OLZ group and @ % in the CNV group ) .", "sentence_id": 6}
+{"abstract_id": "25009161", "label": "results", "text": "Approximately , @ % of patients in the CNV group received haloperidol .", "sentence_id": 7}
+{"abstract_id": "25009161", "label": "results", "text": "No significant difference in time to developing persistent TD was observed during treatment with OLZ or CNV ( cumulative incidence : OLZ , @ % -LSB- @ % confidence interval -LSB- @ % CI -RSB- : @-@ @ -RSB- ; CNV , @ % -LSB- @ % CI : @-@ @ -RSB- , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25009161", "label": "results", "text": "The exposure-adjusted event rates per @ person-years were not significantly different between treatment groups : OLZ ( @ ) and CNV ( @ ; ratio : @ ; @ % CI : @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25009161", "label": "results", "text": "Post hoc analyses revealed a significantly lower risk of at least moderately severe persistent TD persisting for @ month ( P = @ ) and probable TD not persisting for @ month ( Criterion A , P = @ ; Criterion B , P = @ ) in OLZ-treated patients .", "sentence_id": 10}
+{"abstract_id": "25009161", "label": "results", "text": "For those patients without significant extrapyramidal symptoms at baseline , significantly more patients in the CNV treatment group developed treatment-emergent parkinsonism than for patients in the OLZ treatment group ( CNV : @ % , @ of @ patients ; OLZ @ % , @ of @ patients ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25009161", "label": "results", "text": "No significant difference between the groups was observed for treatment-emergent akathisia ( CNV : @ % , @ of @ patients ; OLZ : @ % , @ of @ patients ; P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25009161", "label": "conclusions", "text": "The cumulative incidence of persistent TD was low and the risk of persistent TD did not differ significantly among predominantly older adult patients having dementia with acute psychosis or agitation treated with OLZ or CNV .", "sentence_id": 13}
+{"abstract_id": "25186820", "label": "background", "text": "The effect of anaesthesia on postoperative outcome is unclear .", "sentence_id": 0}
+{"abstract_id": "25186820", "label": "background", "text": "Cardioprotective properties of volatile anaesthetics have been demonstrated experimentally and in haemodynamically stable patients undergoing coronary artery bypass grafting .", "sentence_id": 1}
+{"abstract_id": "25186820", "label": "background", "text": "Their effects in patients undergoing high-risk cardiac surgery have not been reported .", "sentence_id": 2}
+{"abstract_id": "25186820", "label": "methods", "text": "We performed a multicentre , randomized , parallel group , controlled study among patients undergoing high-risk cardiac surgery ( combined valvular and coronary surgery ) in @-@ .", "sentence_id": 3}
+{"abstract_id": "25186820", "label": "methods", "text": "One hundred subjects assigned to the treatment group received sevoflurane for anaesthesia maintenance , while @ subjects assigned to the control group received propofol-based total i.v. anaesthesia .", "sentence_id": 4}
+{"abstract_id": "25186820", "label": "methods", "text": "The primary outcome was a composite of death , prolonged intensive care unit ( ICU ) stay , or both .", "sentence_id": 5}
+{"abstract_id": "25186820", "label": "methods", "text": "Thirty day and @ yr follow-up , focused on mortality , was performed .", "sentence_id": 6}
+{"abstract_id": "25186820", "label": "results", "text": "All @ subjects completed the follow-up and were included in efficacy analyses , conducted according to the intention-to-treat principle .", "sentence_id": 7}
+{"abstract_id": "25186820", "label": "results", "text": "Death , prolonged ICU stay , or both occurred in @ out of @ subjects ( @ % ) in the propofol group and in @ out of @ subjects ( @ % ) in the sevoflurane group ; relative risk @ , @ % confidence interval @-@ @ ; P = @ .", "sentence_id": 8}
+{"abstract_id": "25186820", "label": "results", "text": "No difference was identified in postoperative cardiac troponin release -LSB- @ ( @-@ ) compared with @ ( @-@ @ ) ng ml ( -@ ) , P = @ -RSB- , @ yr all-cause mortality -LSB- @/@ ( @ % ) compared with @/@ ( @ % ) , P = @ -RSB- , re-hospitalizations -LSB- @/@ ( @ % ) compared with @/@ ( @ % ) , P = @ -RSB- , and adverse cardiac events -LSB- @/@ ( @ % ) compared with @/@ ( @ % ) , P = @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "25186820", "label": "conclusions", "text": "There was no observed beneficial effect of sevoflurane on the composite endpoint of prolonged ICU stay , mortality , or both in patients undergoing high-risk cardiac surgery .", "sentence_id": 10}
+{"abstract_id": "25480782", "label": "background", "text": "Characteristics and outcomes of patients with heart failure and reduced ejection fraction receiving care at Veterans Affairs ( VA ) versus non-VA hospitals have not been previously reported .", "sentence_id": 0}
+{"abstract_id": "25480782", "label": "results", "text": "In the randomized controlled Beta-blocker Evaluation of Survival Trial ( BEST ; @-@ ) , of the @ ( bucindolol = @ ; placebo = @ ) patients with heart failure and left ventricular ejection fraction @ % , @ received care at VA hospitals , of which @ % ( n = @ ) were male .", "sentence_id": 1}
+{"abstract_id": "25480782", "label": "results", "text": "Of the @ receiving care at non-VA hospitals , @ % ( n = @ ) were male .", "sentence_id": 2}
+{"abstract_id": "25480782", "label": "results", "text": "Our analyses were restricted to these @ male patients .", "sentence_id": 3}
+{"abstract_id": "25480782", "label": "results", "text": "VA patients were older with higher symptom and comorbidity burdens .", "sentence_id": 4}
+{"abstract_id": "25480782", "label": "results", "text": "There was no significant between-group difference in unadjusted primary end point of @-year all-cause mortality ( @ % VA versus @ % non-VA ; hazard ratio associated with VA hospitals , @ ; @ % confidence interval , @-@ @ ) , which remained unchanged after adjustment for age and race ( hazard ratio , @ ; @ % confidence interval , @-@ @ ) or multivariable adjustment , including cardiovascular morbidities ( hazard ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25480782", "label": "results", "text": "There was no between-group difference in cause-specific mortalities or hospitalizations .", "sentence_id": 6}
+{"abstract_id": "25480782", "label": "results", "text": "Chronic kidney disease , pulmonary edema , left ventricular ejection fraction < @ % , and peripheral arterial disease were significant predictors of mortality for both groups .", "sentence_id": 7}
+{"abstract_id": "25480782", "label": "results", "text": "African America race , New York Heart Association class IV symptoms , atrial fibrillation , and right ventricular ejection fraction < @ % were associated with higher mortality among non-VA hospital patients only ; however , these differences from VA patients were not significant .", "sentence_id": 8}
+{"abstract_id": "25480782", "label": "conclusions", "text": "Patients with heart failure and reduced ejection fraction receiving care at VA hospitals were older and sicker ; yet their risk of mortality and hospitalization was similar to younger and healthier patients receiving care at non-VA hospitals .", "sentence_id": 9}
+{"abstract_id": "24582046", "label": "objective", "text": "The aim of this study was to assess the effectiveness and safety of different strategies of ivabradine therapy by comparing the effects on heart rate ( HR ) , blood pressure ( BP ) , and image quality of coronary CT angiography ( CTA ) .", "sentence_id": 0}
+{"abstract_id": "24582046", "label": "methods", "text": "A total of @ consecutive patients were randomly assigned to @ groups of oral premedication with ivabradine @ mg ( single dose ) , @ mg ( single dose ) , and @ mg twice daily for @ days , prospectively .", "sentence_id": 1}
+{"abstract_id": "24582046", "label": "methods", "text": "Patients using HR-lowering drugs and patients with - blockade contraindication were excluded .", "sentence_id": 2}
+{"abstract_id": "24582046", "label": "methods", "text": "The target HR was @ beats/min .", "sentence_id": 3}
+{"abstract_id": "24582046", "label": "methods", "text": "In addition @ to @ mg of intravenous metoprolol was administered to the patients at the CT unit , if required .", "sentence_id": 4}
+{"abstract_id": "24582046", "label": "methods", "text": "The systolic and diastolic blood BP values and the HRs were recorded .", "sentence_id": 5}
+{"abstract_id": "24582046", "label": "methods", "text": "Image quality was assessed for @ of @ coronary segments with a @-point grading scale .", "sentence_id": 6}
+{"abstract_id": "24582046", "label": "methods", "text": "Results were compared with the Kruskal-Wallis test , one-way ANOVA , and @ test .", "sentence_id": 7}
+{"abstract_id": "24582046", "label": "results", "text": "Reductions in mean HR after the treatment were @ @ , @ @ , and @ @ beats/min for groups @ , @ , and @ , respectively .", "sentence_id": 8}
+{"abstract_id": "24582046", "label": "results", "text": "With the total additional therapies , @ % , @ % , and @ % of the patients achieved HR < @ beats/min in groups @ , @ , and @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24582046", "label": "results", "text": "The mean BP values before coronary CTA were not significantly changed except for patients in group @ .", "sentence_id": 10}
+{"abstract_id": "24582046", "label": "results", "text": "Unacceptable ( score @ ) image quality was obtained in only @ % , @ % , and @ % of all the coronary segments , in groups @ , @ , and @ , respectively .", "sentence_id": 11}
+{"abstract_id": "24582046", "label": "conclusions", "text": "Our study indicates that coronary CTA with premedication with oral ivabradine in all @ strategies is safe and effective in reducing HR , in particular with a - blockade combination .", "sentence_id": 12}
+{"abstract_id": "24582046", "label": "conclusions", "text": "All @ ivabradine regimes may be an alternative strategy for HR lowering in patients undergoing coronary CTA .", "sentence_id": 13}
+{"abstract_id": "24582046", "label": "conclusions", "text": "Ivabradine @ mg ( single dose ) and ivabradine @ mg twice daily for @ days are superior to the ivabradine @-mg single-dose regime for HR lowering without adjunctive intravenous - blocker usage .", "sentence_id": 14}
+{"abstract_id": "24925124", "label": "objective", "text": "There has been no systematic investigation of the individual and combined effects of impaired glucose tolerance ( IGT ) and obesity on cognitive function in the absence of ageing .", "sentence_id": 0}
+{"abstract_id": "24925124", "label": "objective", "text": "The aims were to examine the effects of IGT and increased waist circumference on cognitive function in ostensibly healthy adults , and to investigate whether a low glycaemic load ( GL ) breakfast can attenuate cognitive impairments in these populations .", "sentence_id": 1}
+{"abstract_id": "24925124", "label": "results", "text": "Sixty five females aged @-@ years were classified into one of four groups following waist circumference ( WC ) measurements and an oral glucose tolerance test : NGT/low WC ( n = @ ) , NGT/high WC ( n = @ ) , IGT/low WC ( n = @ ) , IGT/high WC ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24925124", "label": "results", "text": "Memory , psychomotor and executive functions were examined @ and @ min after consuming low GL , high GL and water breakfasts according to a randomised , crossover , counterbalanced design .", "sentence_id": 3}
+{"abstract_id": "24925124", "label": "results", "text": "IGT was associated with impairment of verbal and spatial memory , and psychomotor function relative to females with NGT , independent of waist circumference .", "sentence_id": 4}
+{"abstract_id": "24925124", "label": "results", "text": "Increased waist circumference was associated with impairment of verbal memory and executive function relative to females with low WC , independent of IGT .", "sentence_id": 5}
+{"abstract_id": "24925124", "label": "results", "text": "Consumption of the LGL breakfast attenuated verbal memory impairment in the IGT/high WC group relative to the HGL breakfast and no energy control .", "sentence_id": 6}
+{"abstract_id": "24925124", "label": "conclusions", "text": "Increased central adiposity and abnormalities in glucose tolerance preceding type @ diabetes can have demonstrable negative effects on cognitive function , even in ostensibly healthy , middle-aged females .", "sentence_id": 7}
+{"abstract_id": "24925124", "label": "conclusions", "text": "The potential for GL manipulations to modulate glycaemic response and cognitive function in type @ diabetes and obesity merits further investigation .", "sentence_id": 8}
+{"abstract_id": "25027257", "label": "background", "text": "Tracheal intubation with Macintosh laryngoscope is taught to medical students as it is a lifesaving procedure .", "sentence_id": 0}
+{"abstract_id": "25027257", "label": "background", "text": "However , it is a difficult technique to learn and the consequences of intubation failure are potentially serious .", "sentence_id": 1}
+{"abstract_id": "25027257", "label": "background", "text": "The Airtraq optical laryngoscope is a relatively novel intubation device , which allows visualization of the glottic plane without alignment of the oral , pharyngeal , and tracheal axes , possessing advantages over Macintosh for novice personnel .", "sentence_id": 2}
+{"abstract_id": "25027257", "label": "background", "text": "We introduced a teaching mode featured with a progressive evaluation scheme for preparation and performance of tracheal intubation with medical students in this prospective randomized crossover trial who had no prior airway management experience to find the superior one .", "sentence_id": 3}
+{"abstract_id": "25027257", "label": "methods", "text": "Twenty-six medical students of the @-year programme in the @th year participated in this trial , when they did their one-week rotation in the department of anaesthesiology .", "sentence_id": 4}
+{"abstract_id": "25027257", "label": "methods", "text": "Each of the students intubated @ patients , who were scheduled for surgeries under general anaesthesia , each laryngoscope for @ patients respectively .", "sentence_id": 5}
+{"abstract_id": "25027257", "label": "methods", "text": "One hundred and forty-nine consecutive patients scheduled for surgical procedures requiring tracheal intubation were enrolled .", "sentence_id": 6}
+{"abstract_id": "25027257", "label": "methods", "text": "Patients were randomly allocated to undergo tracheal intubation using Macintosh ( n = @ ) or Airtraq ( n = @ ) laryngoscope .", "sentence_id": 7}
+{"abstract_id": "25027257", "label": "methods", "text": "The progressive evaluation scheme was applied to each intubation attempt .", "sentence_id": 8}
+{"abstract_id": "25027257", "label": "results", "text": "Intubation success rate was significantly higher in Airtraq group than Macintosh group ( @ % vs. @ % , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25027257", "label": "results", "text": "Duration of glottis exposure was significantly shorter in Airtraq group compared to Macintosh group ( @ @ s vs. @ @ s , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25027257", "label": "results", "text": "A grade I Cormack and Lehane glottic view was obtained in @ % of patients in the Airtraq group versus @ % of patients in the Macintosh group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25027257", "label": "results", "text": "Duration of intubation in Airtraq group was significantly shorter ( @ @ s vs. @ @ s , P < @ ) compared to Macintosh group .", "sentence_id": 12}
+{"abstract_id": "25027257", "label": "conclusions", "text": "Airtraq laryngoscope is easier to master for novice personnel with a higher intubation success rate and shorter intubation duration compared with the Macintosh laryngoscope .", "sentence_id": 13}
+{"abstract_id": "24884894", "label": "background", "text": "Previously considered as a disease of the affluent , west or urban people and not of public health importance , diabetes mellitus is increasingly becoming a significant cause of morbidity and mortality in sub-Saharan Africa .", "sentence_id": 0}
+{"abstract_id": "24884894", "label": "background", "text": "However , population-based data to inform prevention , treatment and control are lacking .", "sentence_id": 1}
+{"abstract_id": "24884894", "label": "methods", "text": "Using the WHO STEPwise approach to chronic disease risk factor surveillance , a population-based , nationwide cross-sectional survey was conducted between July and September @ on participants aged @-@ years .", "sentence_id": 2}
+{"abstract_id": "24884894", "label": "methods", "text": "A multi-stage cluster sample design and weighting were used to produce a national representative data for that age range .", "sentence_id": 3}
+{"abstract_id": "24884894", "label": "methods", "text": "Detailed findings on the magnitude of diabetes mellitus and impaired fasting blood glucose are presented in this paper .", "sentence_id": 4}
+{"abstract_id": "24884894", "label": "results", "text": "Fasting blood glucose measurement was conducted on @ participants ( @ % females , @ % from rural areas ) .", "sentence_id": 5}
+{"abstract_id": "24884894", "label": "results", "text": "The age - sex standardised population-based mean fasting blood glucose was @ mmol/L ( @ % CI @-@ @ mmol/L ) with no significant differences by age , sex and location ( urban/rural ) .", "sentence_id": 6}
+{"abstract_id": "24884894", "label": "results", "text": "The overall prevalence of impaired fasting blood glucose was @ % ( @ % CI @ % -@ % ) .", "sentence_id": 7}
+{"abstract_id": "24884894", "label": "results", "text": "Prevalence of impaired blood glucose was higher in men than in women , @ % ( @ % CI @ % -@ % ) vs @ % ( @ % CI @ % - @ % ) , p < @ .", "sentence_id": 8}
+{"abstract_id": "24884894", "label": "results", "text": "In both men and women , prevalence of raised fasting blood glucose or currently on medication for diabetes was @ % ( @ % CI @ % - @ % ) .", "sentence_id": 9}
+{"abstract_id": "24884894", "label": "results", "text": "Although the prevalence of diabetes was higher in men than women , @ % ( @ % CI @ % -@ % ) vs @ % ( @ % CI @ % -@ % ) , in rural than urban , @ % ( @ % CI @ % -@ % ) vs @ % ( @ % CI @ % -@ % ) and in males in rural than males in urban , @ % ( @ % CI @ % -@ % ) vs @ % ( @ % CI @ % -@ % ) , the differences were not statistically significant , p > @ .", "sentence_id": 10}
+{"abstract_id": "24884894", "label": "results", "text": "Compared to previous estimates , prevalence of diabetes increased from < @ % in @s to @ % in @ ( this study ) .", "sentence_id": 11}
+{"abstract_id": "24884894", "label": "conclusions", "text": "High prevalence of impaired fasting blood glucose and diabetes mellitus call for the implementation of primary healthcare approaches such as the WHO package for essential non-communicable diseases to promote healthy lifestyles , early detection , treatment and control .", "sentence_id": 12}
+{"abstract_id": "25498773", "label": "background", "text": "Malaria rapid diagnostic tests ( RDTs ) are a valid alternative to malaria testing with microscopy and are recommended for the testing of febrile patients before prescribing an antimalarial .", "sentence_id": 0}
+{"abstract_id": "25498773", "label": "background", "text": "There is a need for interventions to support the uptake of RDTs by health workers .", "sentence_id": 1}
+{"abstract_id": "25498773", "label": "objective", "text": "To evaluate the cost-effectiveness of introducing RDTs with basic or enhanced training in health facilities in which microscopy was available , compared with current practice .", "sentence_id": 2}
+{"abstract_id": "25498773", "label": "methods", "text": "A three-arm cluster randomized trial was conducted in @ facilities in central and northwest Cameroon .", "sentence_id": 3}
+{"abstract_id": "25498773", "label": "methods", "text": "Basic training had a practical session on RDTs and lectures on malaria treatment guidelines .", "sentence_id": 4}
+{"abstract_id": "25498773", "label": "methods", "text": "Enhanced training included small-group activities designed to change health workers ' practice and reduce the consumption of antimalarials among test-negative patients .", "sentence_id": 5}
+{"abstract_id": "25498773", "label": "methods", "text": "The primary outcome was the proportion of febrile patients correctly treated : febrile patients should be tested for malaria , artemisinin combination therapy should be prescribed for confirmed cases , and no antimalarial should be prescribed for patients who are test-negative .", "sentence_id": 6}
+{"abstract_id": "25498773", "label": "methods", "text": "Individual patient data were obtained from facility records and an exit survey .", "sentence_id": 7}
+{"abstract_id": "25498773", "label": "methods", "text": "Costs were estimated from a societal perspective using project reports and patient exit data .", "sentence_id": 8}
+{"abstract_id": "25498773", "label": "methods", "text": "The analysis used bivariate multilevel modeling and adjusted for imbalance in baseline covariates .", "sentence_id": 9}
+{"abstract_id": "25498773", "label": "results", "text": "Incremental cost per febrile patient correctly treated was $ @ for the basic arm and $ @ for the enhanced arm .", "sentence_id": 10}
+{"abstract_id": "25498773", "label": "results", "text": "On scale-up , it was estimated that RDTs with enhanced training would save $ @ per additional febrile patient correctly treated .", "sentence_id": 11}
+{"abstract_id": "25498773", "label": "conclusions", "text": "Introducing RDTs with enhanced training was more cost-effective than RDTs with basic training when each was compared with current practice .", "sentence_id": 12}
+{"abstract_id": "25238874", "label": "background", "text": "Functional decline and frailty are common in community dwelling older adults , increasing the risk of adverse outcomes .", "sentence_id": 0}
+{"abstract_id": "25238874", "label": "background", "text": "Given this , we investigated the prevalence of frailty-associated risk factors and their distribution according to the severity of perceived risk in a cohort of community dwelling older adults , using the Risk Instrument for Screening in the Community ( RISC ) .", "sentence_id": 1}
+{"abstract_id": "25238874", "label": "methods", "text": "A cohort of @ community dwelling older adults were scored for frailty by their public health nurse ( PHN ) using the Clinical Frailty Scale ( CFS ) and for risk of three adverse outcomes : i ) institutionalisation , ii ) hospitalisation and iii ) death , within the next year , from one ( lowest ) to five ( highest ) using the RISC .", "sentence_id": 2}
+{"abstract_id": "25238874", "label": "methods", "text": "Prior to scoring , PHNs stated whether they regarded patients as frail .", "sentence_id": 3}
+{"abstract_id": "25238874", "label": "results", "text": "The median age of patients was @years ( interquartile range @ ) , of whom @ % were female and @ % were living alone .", "sentence_id": 4}
+{"abstract_id": "25238874", "label": "results", "text": "The median Abbreviated Mental Test Score ( AMTS ) was @ ( @ ) and Barthel Index was @/@ ( @ ) .", "sentence_id": 5}
+{"abstract_id": "25238874", "label": "results", "text": "PHNs regarded @ % of patients as frail , while the CFS categorized @ % ( scoring @ ) as frail .", "sentence_id": 6}
+{"abstract_id": "25238874", "label": "results", "text": "Dividing patients into low-risk ( score one or two ) , medium-risk ( score three ) and high-risk ( score four or five ) using the RISC showed that @ % were considered high risk of institutionalization , @ % for hospitalization , and @ % for death , within one year of the assessment .", "sentence_id": 7}
+{"abstract_id": "25238874", "label": "results", "text": "There were significant differences in median CFS ( @/@ versus @/@ versus @/@ , p < @ ) , Barthel Index ( @/@ versus @/@ versus @/@ , p < @ ) and mean AMTS scores ( @ versus @ versus @ , p < @ ) between those considered low , medium and high risk of institutionalisation respectively .", "sentence_id": 8}
+{"abstract_id": "25238874", "label": "results", "text": "Differences were also statistically significant for hospitalisation and death .", "sentence_id": 9}
+{"abstract_id": "25238874", "label": "results", "text": "Age , gender and living alone were inconsistently associated with perceived risk .", "sentence_id": 10}
+{"abstract_id": "25238874", "label": "results", "text": "Frailty most closely correlated with functional impairment , r = -@ , p < @ .", "sentence_id": 11}
+{"abstract_id": "25238874", "label": "conclusions", "text": "The majority of patients in this community sample were perceived to be low risk for adverse outcomes .", "sentence_id": 12}
+{"abstract_id": "25238874", "label": "conclusions", "text": "Frailty , cognitive impairment and functional status were markers of perceived risk .", "sentence_id": 13}
+{"abstract_id": "25238874", "label": "conclusions", "text": "Age , gender and social isolation were not and may not be useful indicators when triaging community dwellers .", "sentence_id": 14}
+{"abstract_id": "25238874", "label": "conclusions", "text": "The RISC now requires validation against adverse outcomes .", "sentence_id": 15}
+{"abstract_id": "24369195", "label": "background", "text": "Currently , there is limited data on the prevention of chemotherapy-induced nausea and vomiting ( CINV ) in Indian patients .", "sentence_id": 0}
+{"abstract_id": "24369195", "label": "objective", "text": "This post hoc study assessed the efficacy and safety of fosaprepitant compared with aprepitant for prevention of CINV in the Indian population .", "sentence_id": 1}
+{"abstract_id": "24369195", "label": "objective", "text": "A subgroup analysis was performed from data collected in a phase @ study of intravenous ( IV ) fosaprepitant or oral aprepitant , plus the @-HT @ antagonist ondansetron and the corticosteroid dexamethasone , in cisplatin-nave patients with solid malignancies .", "sentence_id": 2}
+{"abstract_id": "24369195", "label": "methods", "text": "Patients scheduled to receive cisplatin ( @ mg/m @ ) were administered a single IV dose of fosaprepitant dimeglumine ( @ mg ) on day @ or a @-day dosing regimen of oral aprepitant ( day @:@ mg , days @ and @:@ mg ) with standard doses of ondansetron and dexamethasone .", "sentence_id": 3}
+{"abstract_id": "24369195", "label": "methods", "text": "Patients recorded nausea and/or vomiting episodes and their use of rescue medication and were monitored for adverse events ( AEs ) and tolerability .", "sentence_id": 4}
+{"abstract_id": "24369195", "label": "methods", "text": "Differences in response rates between fosaprepitant and aprepitant were calculated using the Miettinen and Nurminen method .", "sentence_id": 5}
+{"abstract_id": "24369195", "label": "results", "text": "In the Indian subpopulation ( n = @ ) , efficacy was similar for patients in both the fosaprepitant or aprepitant groups ; complete response in the overall , acute , and delayed phases and no vomiting in all phases were approximately @ percentage points higher in the fosaprepitant group compared with the aprepitant group .", "sentence_id": 6}
+{"abstract_id": "24369195", "label": "results", "text": "Fosaprepitant was generally well-tolerated ; common AEs were similar to oral aprepitant .", "sentence_id": 7}
+{"abstract_id": "24369195", "label": "conclusions", "text": "IV fosaprepitant is as safe and effective as oral aprepitant in the Indian subpopulation and offers an alternative to the oral formulation .", "sentence_id": 8}
+{"abstract_id": "24281396", "label": "background", "text": "Collaborative stepped care ( CSC ) may be an appropriate model to provide evidence-based treatment for anxiety disorders in primary care .", "sentence_id": 0}
+{"abstract_id": "24281396", "label": "methods", "text": "In a cluster randomised controlled trial , the effectiveness of CSC compared to care as usual ( CAU ) for adults with panic disorder ( PD ) or generalised anxiety disorder ( GAD ) in primary care was evaluated .", "sentence_id": 1}
+{"abstract_id": "24281396", "label": "methods", "text": "Thirty-one psychiatric nurses who provided their services to @ primary care practices in the Netherlands were randomised to deliver CSC ( @ psychiatric nurses , @ practices ) or CAU ( @ psychiatric nurses , @ practices ) .", "sentence_id": 2}
+{"abstract_id": "24281396", "label": "methods", "text": "CSC was provided by the psychiatric nurses ( care managers ) in collaboration with the general practitioner and a consultant psychiatrist .", "sentence_id": 3}
+{"abstract_id": "24281396", "label": "methods", "text": "The intervention consisted of @ steps , namely guided self-help , cognitive behavioural therapy and antidepressants .", "sentence_id": 4}
+{"abstract_id": "24281396", "label": "methods", "text": "Anxiety symptoms were measured with the Beck Anxiety Inventory ( BAI ) at baseline and after @ , @ , @ and @ months .", "sentence_id": 5}
+{"abstract_id": "24281396", "label": "results", "text": "We recruited @ patients with a DSM-IV diagnosis of PD or GAD , of whom @ received CSC and @ received usual primary care .", "sentence_id": 6}
+{"abstract_id": "24281396", "label": "results", "text": "On the BAI , CSC was superior to CAU -LSB- difference in gain scores from baseline to @ months : -@ , @ % confidence interval ( CI ) -@ to -@ ; @ months : -@ , @ % CI -@ to -@ ; @ months : -@ , @ % CI -@ to -@ ; @ months : -@ , @ % CI -@ to -@ -RSB- .", "sentence_id": 7}
+{"abstract_id": "24281396", "label": "conclusions", "text": "CSC , with guided self-help as a first step , was more effective than CAU for primary care patients with PD or GAD .", "sentence_id": 8}
+{"abstract_id": "24711047", "label": "objective", "text": "Optimizing assessments of rate of progression in Parkinson disease ( PD ) is important in designing clinical trials , especially of potential disease-modifying agents .", "sentence_id": 0}
+{"abstract_id": "24711047", "label": "objective", "text": "To examine the value of measures of impairment , disability , and quality of life in assessing progression in early PD .", "sentence_id": 1}
+{"abstract_id": "24711047", "label": "methods", "text": "Inception cohort analysis of data from @ patients with early , untreated PD who were enrolled in @ multicenter , randomized , double-blind clinical trials .", "sentence_id": 2}
+{"abstract_id": "24711047", "label": "methods", "text": "Participants were randomly assigned to @ of @ treatments ( @ received creatine , @ received minocycline , @ received coenzyme Q@ , @ received GPI-@ , and @ received placebo ) .", "sentence_id": 3}
+{"abstract_id": "24711047", "label": "methods", "text": "We assessed the association between the rates of change in measures of impairment , disability , and quality of life and time to initiation of symptomatic treatment .", "sentence_id": 4}
+{"abstract_id": "24711047", "label": "methods", "text": "Time between baseline assessment and need for the initiation of symptomatic pharmaceutical treatment for PD was the primary indicator of disease progression .", "sentence_id": 5}
+{"abstract_id": "24711047", "label": "results", "text": "After adjusting for baseline confounding variables with regard to the Unified Parkinson 's Disease Rating Scale ( UPDRS ) Part II score , the UPDRS Part III score , the modified Rankin Scale score , level of education , and treatment group , we assessed the rate of change for the following measurements : the UPDRS Part II score ; the UPDRS Part III score ; the Schwab and England Independence Scale score ( which measures activities of daily living ) ; the Total Functional Capacity scale ; the @-item Parkinson 's Disease Questionnaire , summary index , and activities of daily living subscale ; and version @ of the @-item Short Form Health Survey Physical Summary and Mental Summary .", "sentence_id": 6}
+{"abstract_id": "24711047", "label": "results", "text": "Variables reaching the statistical threshold in univariate analysis were entered into a multivariable Cox proportional hazards model using time to symptomatic treatment as the dependent variable .", "sentence_id": 7}
+{"abstract_id": "24711047", "label": "results", "text": "More rapid change ( ie , worsening ) in the UPDRS Part II score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ scale unit change per @ months ) , the UPDRS Part III score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ scale unit change per @ months ) , and the Schwab and England Independence Scale score ( hazard ratio , @ -LSB- @ % CI , @-@ @ -RSB- for @ percentage point change per @ months ) was associated with earlier need for symptomatic therapy .", "sentence_id": 8}
+{"abstract_id": "24711047", "label": "conclusions", "text": "AND RELEVANCE In early PD , the UPDRS Part II score and Part III score and the Schwab and England Independence Scale score can be used to measure disease progression , whereas the @-item Parkinson 's Disease Questionnaire and summary index , Total Functional Capacity scale , and the @-item Short Form Health Survey Physical Summary and Mental Summary are not sensitive to change .", "sentence_id": 9}
+{"abstract_id": "24411480", "label": "background", "text": "To examine the effects of complex cognitive ( mahjong ) and physical ( Tai Chi ) activities on dementia severity in nursing home residents with dementia .", "sentence_id": 0}
+{"abstract_id": "24411480", "label": "methods", "text": "Cluster-randomized open-label controlled design .", "sentence_id": 1}
+{"abstract_id": "24411480", "label": "methods", "text": "@ residents were randomized by nursing home into three conditions : mahjong , Tai Chi , and simple handicrafts ( control ) .", "sentence_id": 2}
+{"abstract_id": "24411480", "label": "methods", "text": "Activities were conducted three times a week for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24411480", "label": "methods", "text": "Clinical Dementia Rating ( CDR ) was taken at @ ( baseline ) , @ ( post-treatment ) , @ , and @ months .", "sentence_id": 4}
+{"abstract_id": "24411480", "label": "methods", "text": "The outcome measure was CDR sum-of-box , which is a composite measure of both cognitive and functional deterioration in dementia .", "sentence_id": 5}
+{"abstract_id": "24411480", "label": "results", "text": "Intent-to-treat analyses were performed using multilevel regression models .", "sentence_id": 6}
+{"abstract_id": "24411480", "label": "results", "text": "Apolipoprotein E @ allele and education were included as covariates .", "sentence_id": 7}
+{"abstract_id": "24411480", "label": "results", "text": "Neither treatments had effects on the cognitive and functional components of the CDR , but mahjong had a significant interaction with time on the CDR sum-of-box total , suggesting a slower rate of global deterioration in the mahjong group as compared with the control group .", "sentence_id": 8}
+{"abstract_id": "24411480", "label": "conclusions", "text": "Mahjong led to a gradual improvement in global functioning and a slightly slower rate of dementia progression over time .", "sentence_id": 9}
+{"abstract_id": "24411480", "label": "conclusions", "text": "The effect was generalized and was not specific to cognition or daily functioning .", "sentence_id": 10}
+{"abstract_id": "24430407", "label": "background", "text": "There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee .", "sentence_id": 0}
+{"abstract_id": "24430407", "label": "background", "text": "Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation .", "sentence_id": 1}
+{"abstract_id": "24430407", "label": "background", "text": "In a randomized , double-blind , controlled study , the safety of the intra-articular injection of human mesenchymal stem cells into the knee , the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy , and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated .", "sentence_id": 2}
+{"abstract_id": "24430407", "label": "methods", "text": "A total of fifty-five patients at seven institutions underwent a partial medial meniscectomy .", "sentence_id": 3}
+{"abstract_id": "24430407", "label": "methods", "text": "A single superolateral knee injection was given within seven to ten days after the meniscectomy .", "sentence_id": 4}
+{"abstract_id": "24430407", "label": "methods", "text": "Patients were randomized to one of three treatment groups : Group A , in which patients received an injection of @ @ allogeneic mesenchymal stem cells ; Group B , @ @ allogeneic mesenchymal stem cells ; and the control group , a sodium hyaluronate ( hyaluronic acid/hyaluronan ) vehicle control .", "sentence_id": 5}
+{"abstract_id": "24430407", "label": "methods", "text": "Patients were followed to evaluate safety , meniscus regeneration , the overall condition of the knee joint , and clinical outcomes at intervals through two years .", "sentence_id": 6}
+{"abstract_id": "24430407", "label": "methods", "text": "Evaluations included sequential magnetic resonance imaging ( MRI ) .", "sentence_id": 7}
+{"abstract_id": "24430407", "label": "results", "text": "No ectopic tissue formation or clinically important safety issues were identified .", "sentence_id": 8}
+{"abstract_id": "24430407", "label": "results", "text": "There was significantly increased meniscal volume ( defined a priori as a @ % threshold ) determined by quantitative MRI in @ % of patients in Group A and @ % in Group B at twelve months post meniscectomy ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24430407", "label": "results", "text": "No patients in the control group met the @ % threshold for increased meniscal volume .", "sentence_id": 10}
+{"abstract_id": "24430407", "label": "results", "text": "Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control , on the basis of visual analog scale assessments .", "sentence_id": 11}
+{"abstract_id": "24430407", "label": "conclusions", "text": "There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells .", "sentence_id": 12}
+{"abstract_id": "24430407", "label": "conclusions", "text": "These results support the study of human mesenchymal stem cells for the apparent knee-tissue regeneration and protective effects .", "sentence_id": 13}
+{"abstract_id": "25648901", "label": "background", "text": "Amyotrophic lateral sclerosis patients have significant respiratory abnormalities with incomplete understanding of respiratory control .", "sentence_id": 0}
+{"abstract_id": "25648901", "label": "background", "text": "This study analyzes electromyography ( EMG ) of the diaphragm ( dEMG ) using implanted diaphragm pacing ( DP ) electrodes .", "sentence_id": 1}
+{"abstract_id": "25648901", "label": "methods", "text": "Retrospective analysis of dEMG data were obtained during Institutional Review Board and US Food and Drug Administration approved trials .", "sentence_id": 2}
+{"abstract_id": "25648901", "label": "methods", "text": "The electrodes were used to analyze epochs of dEMG during multiple respiratory cycles .", "sentence_id": 3}
+{"abstract_id": "25648901", "label": "results", "text": "Fifty-three patients were implanted .", "sentence_id": 4}
+{"abstract_id": "25648901", "label": "results", "text": "Thirty-six had bilateral dEMG assessments , @ had continuous overnight readings with pulse oximetry , and @ had serial analysis .", "sentence_id": 5}
+{"abstract_id": "25648901", "label": "results", "text": "Several findings revealed an alteration in the central respiratory drive including central apnea , hypoventilation , and hypercarbia .", "sentence_id": 6}
+{"abstract_id": "25648901", "label": "results", "text": "The electrodes showed unilateral dysfunction and demonstrated noninvasive ventilation suppression of diaphragm activity .", "sentence_id": 7}
+{"abstract_id": "25648901", "label": "results", "text": "DP can be used for serial monitoring , to decrease hypercarbia , improve sleep , and decrease atrophy .", "sentence_id": 8}
+{"abstract_id": "25648901", "label": "conclusions", "text": "Multiple abnormalities of respiratory control can be seen in amyotrophic lateral sclerosis patients using dEMG through therapeutic DP electrodes .", "sentence_id": 9}
+{"abstract_id": "25648901", "label": "conclusions", "text": "DP is used to overcome instability of respiratory control when there are intact diaphragm motor units leading to improved survival .", "sentence_id": 10}
+{"abstract_id": "24593225", "label": "background", "text": "Atherosclerotic cardiovascular disease ( CVD ) is the most common cause of morbidity and mortality among hemodialysis ( HD ) patients .", "sentence_id": 0}
+{"abstract_id": "24593225", "label": "background", "text": "It has been attributed , among other causes , to hypertension and dyslipidemia .", "sentence_id": 1}
+{"abstract_id": "24593225", "label": "background", "text": "The aim of the present study was to investigate the effect of a year-long consumption of Pomegranate juice ( PJ ) , on two traditional cardiovascular ( CV ) risk factors : hypertension and lipid profile , as well as on cardiovascular events .", "sentence_id": 2}
+{"abstract_id": "24593225", "label": "methods", "text": "@ HD patients were randomized to receive @cc of PJ ( @ mM polyphenols ) or matching placebo juice , three times a week for one year .", "sentence_id": 3}
+{"abstract_id": "24593225", "label": "methods", "text": "The primary endpoints were traditional CV risk factors ; blood pressure and lipid profile .", "sentence_id": 4}
+{"abstract_id": "24593225", "label": "methods", "text": "Systolic , diastolic and pulse pressure , plasma levels of triglycerides ( TG ) , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) and total cholesterol were monitored quarterly during the study year .", "sentence_id": 5}
+{"abstract_id": "24593225", "label": "methods", "text": "Secondary endpoint was incidence of cardiovascular events .", "sentence_id": 6}
+{"abstract_id": "24593225", "label": "results", "text": "PJ consumption yielded a significant time response improvement in systolic blood pressure , pulse pressure , triglycerides and HDL level ; an improvement that was not observed in the placebo intake group .", "sentence_id": 7}
+{"abstract_id": "24593225", "label": "results", "text": "These beneficial outcomes were more pronounced among patients with hypertension , high level of triglycerides and low levels of HDL .", "sentence_id": 8}
+{"abstract_id": "24593225", "label": "conclusions", "text": "Regular PJ consumption by HD patients reduced systolic blood pressure and improved lipid profile .", "sentence_id": 9}
+{"abstract_id": "24593225", "label": "conclusions", "text": "These favorable changes may reduce the accelerated atherosclerosis and high incidence of CVD among HD patients .", "sentence_id": 10}
+{"abstract_id": "24256699", "label": "objective", "text": "Statins and calcium channel blockers have been proven beneficial toward improvement of endothelial function .", "sentence_id": 0}
+{"abstract_id": "24256699", "label": "objective", "text": "The aim of this study was to compare the effect of combination therapy of statin and calcium channel blocker with solo treatment in patients with cardiac syndrome X.", "sentence_id": 1}
+{"abstract_id": "24256699", "label": "results", "text": "Sixty-eight patients with cardiac syndrome X were divided randomly into three groups : fluvastatin ( @ mg/day , n = @ ) , diltiazem ( @ mg/day , n = @ ) , and combination of fluvastatin ( @ mg/day ) and diltiazem ( @ mg/day , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24256699", "label": "results", "text": "At the end of @ days , the coronary flow reserve was improved in the three groups ( fluvastatin-treated group : @ % ; diltiazem-treated group : @ % ; fluvastatin + diltiazem-treated group : @ % , all P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24256699", "label": "results", "text": "The time to @ mm ST segment depression increased significantly in the fluvastatin-treated group ( from @ to @ s , P < @ ) , the diltiazem-treated group ( from @ to @ s , P < @ ) , and the fluvastatin + diltiazem-treated group ( from @ to @ s , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24256699", "label": "results", "text": "The improvement in coronary flow reserve and prolonged time to @ mm ST segment depression in the combination treatment group were more remarkable than in those who received monotherapy .", "sentence_id": 5}
+{"abstract_id": "24256699", "label": "results", "text": "Combination therapy also induced a significant increase ( @ % , P < @ ) in nitric oxide and an apparent reduction ( @ % , P < @ ) in endothelin-@ .", "sentence_id": 6}
+{"abstract_id": "24256699", "label": "conclusions", "text": "Combination treatment with fluvastatin and diltiazem is more effective on endothelial function and exercise tolerance than solo treatment in patients with cardiac syndrome X.", "sentence_id": 7}
+{"abstract_id": "24256699", "label": "conclusions", "text": "The benefits of these drugs may be related to the elevation of nitric oxide and reduction of endothelin-@ .", "sentence_id": 8}
+{"abstract_id": "24393120", "label": "background", "text": "Pulmonary embolism ( PE ) is the third most common cause of death from cardiovascular disease .", "sentence_id": 0}
+{"abstract_id": "24393120", "label": "background", "text": "Computed-tomographic pulmonary angiography ( CTPA ) is an accurate and safe test for diagnosing PE .", "sentence_id": 1}
+{"abstract_id": "24393120", "label": "background", "text": "The aim of this retrospective analysis was to evaluate the effects on image quality ( IQ ) of electrocardiogram ( ECG ) gating during CTPA .", "sentence_id": 2}
+{"abstract_id": "24393120", "label": "methods", "text": "Fifty consecutive patients presenting for CTPA were included in the study .", "sentence_id": 3}
+{"abstract_id": "24393120", "label": "methods", "text": "A single acquisition was performed , resulting in two reconstructions : one at @ % of the R-R interval and the other without ECG influence .", "sentence_id": 4}
+{"abstract_id": "24393120", "label": "methods", "text": "IQ evaluation was undertaken by two radiologists , focusing on respiratory and cardiac motion , image noise , low-contrast resolution , vessel and lung clarity , contrast media opacification and artefacts .", "sentence_id": 5}
+{"abstract_id": "24393120", "label": "methods", "text": "Various regions of the lungs and vasculature were evaluated , and IQ scores were statistically compared .", "sentence_id": 6}
+{"abstract_id": "24393120", "label": "results", "text": "For the ECG-tagged reconstructions , IQ was noted to be better overall with regard to vessel clarity ( P < @ ) and cardiac motion ( P < @ ) , while lung clarity was better only in the left lower zone ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24393120", "label": "results", "text": "IQ was better with regard to image noise ( P < @ ) and low-contrast resolution ( P < @ ) in the non-ECG-tagged reconstructions .", "sentence_id": 8}
+{"abstract_id": "24393120", "label": "results", "text": "No statistical IQ difference between the two types of reconstruction was noted with regard to respiratory motion , contrast media opacification or presence of artefacts .", "sentence_id": 9}
+{"abstract_id": "24393120", "label": "conclusions", "text": "The two types of reconstruction provide complementary information for evaluating CTPA results .", "sentence_id": 10}
+{"abstract_id": "25742308", "label": "background", "text": "Adaptive support ventilation ( ASV ) is a closed loop mode of mechanical ventilation ( MV ) that provides a target minute ventilation by automatically adapting inspiratory pressure and respiratory rate with the minimum work of breathing on the part of the patient .", "sentence_id": 0}
+{"abstract_id": "25742308", "label": "background", "text": "The aim of this study was to determine the effect of ASV on total MV duration when compared with pressure assist/control ventilation .", "sentence_id": 1}
+{"abstract_id": "25742308", "label": "methods", "text": "Adult medical patients intubated and mechanically ventilated for > @ h in a medical ICU were randomized to either ASV or pressure assist/control ventilation .", "sentence_id": 2}
+{"abstract_id": "25742308", "label": "methods", "text": "Sedation and medical treatment were standardized for each group .", "sentence_id": 3}
+{"abstract_id": "25742308", "label": "methods", "text": "Primary outcome was the total MV duration .", "sentence_id": 4}
+{"abstract_id": "25742308", "label": "methods", "text": "Secondary outcomes were the weaning duration , number of manual settings of the ventilator , and weaning success rates .", "sentence_id": 5}
+{"abstract_id": "25742308", "label": "results", "text": "Two hundred twenty-nine patients were included .", "sentence_id": 6}
+{"abstract_id": "25742308", "label": "results", "text": "Median MV duration until weaning , weaning duration , and total MV duration were significantly shorter in the ASV group ( @ -LSB- @-@ -RSB- h vs @ -LSB- @-@ -RSB- h , P = @ ; @ -LSB- @-@ -RSB- h vs @ -LSB- @-@ -RSB- h , P = @ ; and @ -LSB- @-@ -RSB- days vs @ -LSB- @-@ -RSB- days , P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "25742308", "label": "results", "text": "Patients in the ASV group required fewer total number of manual settings on the ventilator to reach the desired pH and Paco@ levels ( @ -LSB- @-@ -RSB- vs @ -LSB- @-@ -RSB- , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25742308", "label": "results", "text": "The number of patients extubated successfully on the first attempt was significantly higher in the ASV group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25742308", "label": "results", "text": "Weaning success and mortality at day @ were comparable between the two groups .", "sentence_id": 10}
+{"abstract_id": "25742308", "label": "conclusions", "text": "In medical patients in the ICU , ASV may shorten the duration of weaning and total MV duration with a fewer number of manual ventilator settings .", "sentence_id": 11}
+{"abstract_id": "24498368", "label": "background", "text": "We aim to test the hypothesis that high plasma YKL-@ is associated with short progression-free survival ( PFS ) and overall survival ( OS ) in patients with metastatic colorectal cancer ( mCRC ) treated with first-line oxaliplatin and @-flourouracil with or without cetuximab .", "sentence_id": 0}
+{"abstract_id": "24498368", "label": "methods", "text": "A total of @ patients in the NORDIC VII Study were randomized @ to arm A ( Nordic FLOX ) , arm B ( Nordic FLOX + cetuximab ) , or arm C ( Nordic FLOX + cetuximab for @ weeks followed by cetuximab alone as maintenance therapy ) .", "sentence_id": 1}
+{"abstract_id": "24498368", "label": "methods", "text": "Pretreatment plasma samples were available from @ patients .", "sentence_id": 2}
+{"abstract_id": "24498368", "label": "methods", "text": "Plasma YKL-@ was determined by ELISA and dichotomized according to the age-corrected @ % YKL-@ level in @ healthy subjects .", "sentence_id": 3}
+{"abstract_id": "24498368", "label": "results", "text": "Pretreatment plasma YKL-@ was elevated in @ patients ( @ % ) , and median YKL-@ was higher in patients with mCRC than in healthy subjects ( age adjusted , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24498368", "label": "results", "text": "Patients with elevated YKL-@ had shorter PFS than patients with normal YKL-@ ( @ vs. @ months ; hazard ratio ( HR ) = @ @ % confidence interval ( CI ) @-@ @ P = @ ) and shorter OS ( @ vs. @ months ; HR = @ , @-@ @ , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24498368", "label": "results", "text": "Multivariate Cox analysis demonstrated that elevated pretreatment YKL-@ was an independent biomarker of short OS ( HR = @ , @-@ @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24498368", "label": "results", "text": "The ratio of the updated plasma YKL-@ ( i.e. level after @ , @ , @ weeks of treatment , and at end of treatment compared to the baseline level ) was associated with OS ( HR = @ , @-@ @ , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24498368", "label": "conclusions", "text": "Plasma YKL-@ is an independent prognostic biomarker in patients with mCRC treated with first-line oxaliplatin-based therapy alone or combined with cetuximab .", "sentence_id": 8}
+{"abstract_id": "24497345", "label": "objective", "text": "Intra-myocardial transplantation of CD@ ( + ) bone marrow stem cells ( BMC ) yielded promising results in clinical pilot trials .", "sentence_id": 0}
+{"abstract_id": "24497345", "label": "objective", "text": "We now performed the double-blinded , randomized , placebo-controlled CARDIO@ trial to determine its impact on left ventricular ( LV ) function and clinical symptoms .", "sentence_id": 1}
+{"abstract_id": "24497345", "label": "results", "text": "Sixty patients with chronic ischaemic heart disease and impaired LV function ( left ventricular ejection fraction , LVEF < @ % ) were randomized to undergo either coronary artery bypass grafting ( CABG ) and injection of CD@ ( + ) BMC in the non-transmural , hypokinetic infarct border zone ( CD@ ) , or CABG and placebo injection ( placebo ) .", "sentence_id": 2}
+{"abstract_id": "24497345", "label": "results", "text": "Pre-operative LVEF was @ @ % in CD@ patients and @ @ % in placebo patients .", "sentence_id": 3}
+{"abstract_id": "24497345", "label": "results", "text": "Outcome was assessed after @ months , and the primary endpoint was LVEF measured by cardiac magnetic resonance imaging ( MRI ) at rest .", "sentence_id": 4}
+{"abstract_id": "24497345", "label": "results", "text": "The incidence of adverse events was similar in both groups .", "sentence_id": 5}
+{"abstract_id": "24497345", "label": "results", "text": "There was no difference in @-min walking distance , Minnesota Living with Heart Failure score , or Canadian Cardiovascular Society ( CCS ) class between groups at follow-up , and New York Heart Association class improved more in the placebo group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24497345", "label": "results", "text": "By cardiac MRI , LVEF at @ months was @ @ % in the placebo group and @ @ % in verum patients ( P = @ ) , with an average inter-group difference of -@ % ( @ % CI -@ to @ ) .", "sentence_id": 7}
+{"abstract_id": "24497345", "label": "results", "text": "Systolic or diastolic LV dimensions at @ months were not different , either .", "sentence_id": 8}
+{"abstract_id": "24497345", "label": "results", "text": "In the CD@ group , myocardial perfusion at rest recovered in more LV segments than in the placebo group ( @ vs. @ % , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24497345", "label": "results", "text": "Scar mass decreased by @ @ g in CD@ ( + ) patients ( P = @ ) , but was unchanged in the placebo group ( @ @ g , P = @ ; inter-group difference in change = @ g ( @ % CI -@ to @ ) ) .", "sentence_id": 10}
+{"abstract_id": "24497345", "label": "results", "text": "By speckle-tracking echocardiography , cell-treated patients showed a better recovery of regional wall motion when the target area was posterior .", "sentence_id": 11}
+{"abstract_id": "24497345", "label": "conclusions", "text": "Although there may be some improvements in scar size and regional perfusion , intra-myocardial injection of CD@ ( + ) BMC has no effect on global LV function and clinical symptoms .", "sentence_id": 12}
+{"abstract_id": "24497345", "label": "conclusions", "text": "Improvements in regional myocardial function are only detectable in patients with posterior infarction , probably because the interventricular septum after anterior infarction is not accessible by trans-epicardial injection .", "sentence_id": 13}
+{"abstract_id": "25189358", "label": "background", "text": "Although adolescent girls are the main population for prophylactic human papillomavirus ( HPV ) vaccines , adult women who remain at risk of cervical cancer can also be vaccinated .", "sentence_id": 0}
+{"abstract_id": "25189358", "label": "background", "text": "We report data from the interim analysis of the ongoing VIVIANE study , the aim of which is to assess the efficacy , safety , and immunogenicity of the HPV @/@ AS@-adjuvanted vaccine in adult women .", "sentence_id": 1}
+{"abstract_id": "25189358", "label": "methods", "text": "In this phase @ , multinational , double-blind , randomised controlled trial , we randomly assigned healthy women older than @ years to the HPV @/@ vaccine or control ( @:@ ) , via an internet-based system with an algorithm process that accounted for region , age stratum , baseline HPV DNA status , HPV @/@ serostatus , and cytology .", "sentence_id": 2}
+{"abstract_id": "25189358", "label": "methods", "text": "Enrolment was age-stratified , with about @ % of participants in each of the @-@ and @-@ years age strata and @ % in the @ years and older stratum .", "sentence_id": 3}
+{"abstract_id": "25189358", "label": "methods", "text": "Up to @ % of women in each age stratum could have a history of HPV infection or disease .", "sentence_id": 4}
+{"abstract_id": "25189358", "label": "methods", "text": "The primary endpoint was vaccine efficacy against @-month persistent infection or cervical intraepithelial neoplasia grade @ or higher ( CIN@ + ) associated with HPV @/@ .", "sentence_id": 5}
+{"abstract_id": "25189358", "label": "methods", "text": "The primary analysis was done in the according-to-protocol cohort for efficacy , which consists of women who received all three vaccine or control doses , had negative or low-grade cytology at baseline , and had no history of HPV disease .", "sentence_id": 6}
+{"abstract_id": "25189358", "label": "methods", "text": "Secondary analyses included vaccine efficacy against non-vaccine oncogenic HPV types .", "sentence_id": 7}
+{"abstract_id": "25189358", "label": "methods", "text": "Mean follow-up time was @ months .", "sentence_id": 8}
+{"abstract_id": "25189358", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25189358", "label": "results", "text": "The first participant was enrolled on Feb @ , @ , and the last study visit for the present analysis took place on Dec @ , @ ; @ women were included in the total vaccinated cohort ( n = @ vaccine , n = @ control ) , and @ in the according-to-protocol cohort for efficacy ( n = @ vaccine , n = @ control ) .", "sentence_id": 10}
+{"abstract_id": "25189358", "label": "results", "text": "Vaccine efficacy against HPV @/@-related @-month persistent infection or CIN@ + was significant in all age groups combined ( @ % , @ % CI @-@ ) , in the @-@ years age group ( @ % , @-@ ) , and in the @-@ years age group ( @ % , @-@ ) ; no cases were seen in women aged @ years and older .", "sentence_id": 11}
+{"abstract_id": "25189358", "label": "results", "text": "Vaccine efficacy against atypical squamous cells of undetermined significance or greater associated with HPV @/@ was also significant .", "sentence_id": 12}
+{"abstract_id": "25189358", "label": "results", "text": "We also noted significant cross-protective vaccine efficacy against @-month persistent infection with HPV @ ( @ % , @ % CI @-@ ) and HPV @ ( @ % , @-@ -RSB- ) Serious adverse events occurred in @ ( @ % ) of @ women in the vaccine group and @ ( @ % ) of @ in the control group ; five ( < @ % ) and eight ( < @ % ) of these events , respectively , were believed to be related to vaccination .", "sentence_id": 13}
+{"abstract_id": "25189358", "label": "conclusions", "text": "In women older than @ years , the HPV @/@ vaccine is efficacious against infections and cervical abnormalities associated with the vaccine types , as well as infections with the non-vaccine HPV types @ and @ .", "sentence_id": 14}
+{"abstract_id": "24578074", "label": "objective", "text": "To describe the predictors of nurse actions in response to a mobile health decision-support system ( mHealth DSS ) for guideline-based screening and management of tobacco use .", "sentence_id": 0}
+{"abstract_id": "24578074", "label": "methods", "text": "Observational design focused on an experimental arm of a randomized , controlled trial .", "sentence_id": 1}
+{"abstract_id": "24578074", "label": "methods", "text": "Acute and ambulatory care settings in the New York City metropolitan area .", "sentence_id": 2}
+{"abstract_id": "24578074", "label": "methods", "text": "@,@ patient encounters in which @ RNs enrolled in advanced practice nurse ( APN ) training were prompted by an mHealth DSS to screen for tobacco use and select guideline-based treatment recommendations .", "sentence_id": 3}
+{"abstract_id": "24578074", "label": "methods", "text": "Data were entered and stored during nurse documentation in the mHealth DSS and subsequently stored in the study database where they were retrieved for analysis using descriptive statistics and logistic regressions .", "sentence_id": 4}
+{"abstract_id": "24578074", "label": "methods", "text": "Predictor variables included patient gender , patient race or ethnicity , patient payer source , APN specialty , and predominant payer source in clinical site .", "sentence_id": 5}
+{"abstract_id": "24578074", "label": "methods", "text": "Dependent variables included the number of patient encounters in which the nurse screened for tobacco use , provided smoking cessation teaching and counseling , or referred patients for smoking cessation for patients who indicated a willingness to quit .", "sentence_id": 6}
+{"abstract_id": "24578074", "label": "results", "text": "Screening was more likely to occur in encounters where patients were female , African American , and received care from a nurse in the adult nurse practitioner specialty or in a clinical site in which the predominant payer source was Medicare , Medicaid , or State Children 's Health Insurance Program .", "sentence_id": 7}
+{"abstract_id": "24578074", "label": "results", "text": "In encounters where the patient payer source was other , nurses were less likely to provide tobacco cessation teaching and counseling .", "sentence_id": 8}
+{"abstract_id": "24578074", "label": "conclusions", "text": "mHealth DSS has the potential to affect nurse provision of guideline-based care .", "sentence_id": 9}
+{"abstract_id": "24578074", "label": "conclusions", "text": "However , patient , nurse , and setting factors influence nurse actions in response to an mHealth DSS for tobacco cessation .", "sentence_id": 10}
+{"abstract_id": "24578074", "label": "conclusions", "text": "The combination of a reminder to screen and integration of guideline-based recommendations into the mHealth DSS may reduce racial or ethnic disparities to screening , as well as clinician barriers related to time , training , and familiarity with resources .", "sentence_id": 11}
+{"abstract_id": "25733652", "label": "background", "text": "Although iron supplementation in malaria-free areas mostly reduces infectious morbidity , it can sometimes increase morbidity from infections as a result of the dependence of pathogenic microorganisms on iron .", "sentence_id": 0}
+{"abstract_id": "25733652", "label": "background", "text": "Supplementation with n-@ ( -@ ) long-chain polyunsaturated fatty acids ( LCPUFAs ) improved morbidity in several human studies .", "sentence_id": 1}
+{"abstract_id": "25733652", "label": "background", "text": "However , information on the combined effect of iron and n-@ LCPUFA supplementation on infectious morbidity is limited .", "sentence_id": 2}
+{"abstract_id": "25733652", "label": "objective", "text": "We determined whether n-@ LCPUFAs and iron supplementation , alone or in combination , affected absenteeism and illness in iron-deficient schoolchildren with low fish intake .", "sentence_id": 3}
+{"abstract_id": "25733652", "label": "methods", "text": "A total of @ South African children ( aged @-@ y ) with iron deficiency ( ID ) were randomly divided into @ groups to receive @ ) iron plus placebo , @ ) a mixture of docosahexaenoic acid and eicosapentaenoic acid ( DHA/EPA ) plus placebo , @ ) iron plus DHA/EPA , or @ ) placebo plus placebo as oral supplements @ times/wk for @ mo. .", "sentence_id": 4}
+{"abstract_id": "25733652", "label": "methods", "text": "Morbidity was recorded , and iron-status indexes were measured .", "sentence_id": 5}
+{"abstract_id": "25733652", "label": "methods", "text": "The total phospholipid fatty acid composition of peripheral blood mononuclear cell membranes was analyzed in a subsample ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "25733652", "label": "results", "text": "Iron supplementation increased the number of days with illness when all symptoms were considered ( B : @ ; @ % CI : @ , @ ) as well as illness that was specifically caused by respiratory symptoms ( B : @ ; @ % CI : @ , @ ) , whereas DHA/EPA reduced the number of days with illness at school ( B : -@ ; @ % CI : -@ , -@ ) .", "sentence_id": 7}
+{"abstract_id": "25733652", "label": "results", "text": "The increases caused by iron were reduced to the levels seen in the placebo plus placebo group when iron was provided in combination with DHA/EPA as indicated by significant iron DHA/EPA interactions ( both P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25733652", "label": "conclusions", "text": "Iron supplementation increased morbidity ( mostly respiratory ) in iron-deficient South African schoolchildren with low DHA/EPA intake , but when iron was given in combination with DHA/EPA , this effect was prevented .", "sentence_id": 9}
+{"abstract_id": "25250660", "label": "objective", "text": "Anorexia nervosa ( AN ) is a serious disorder with high rates of morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "25250660", "label": "objective", "text": "Family-based treatment ( FBT ) is an evidence-based therapy for adolescent AN , but less than half of those who receive this approach recover .", "sentence_id": 1}
+{"abstract_id": "25250660", "label": "objective", "text": "Hence , it is important to identify other approaches to prevent the development of the chronic form of AN for which there is no known evidence-based treatment .", "sentence_id": 2}
+{"abstract_id": "25250660", "label": "objective", "text": "To compare FBT with systemic family therapy ( SyFT ) for the treatment of adolescent-onset AN .", "sentence_id": 3}
+{"abstract_id": "25250660", "label": "methods", "text": "Research in Anorexia Nervosa ( RIAN ) is a @-group ( FBT and SyFT ) randomized trial conducted between September @ and April @ .", "sentence_id": 4}
+{"abstract_id": "25250660", "label": "methods", "text": "Interviewers were blinded to the treatment condition .", "sentence_id": 5}
+{"abstract_id": "25250660", "label": "methods", "text": "A total of @ adolescents receiving care at @ outpatient clinics experienced in the treatment of AN were screened .", "sentence_id": 6}
+{"abstract_id": "25250660", "label": "methods", "text": "Of these , @ adolescents did not meet the inclusion criteria and @ declined to participate ; hence , @ adolescents ( aged @-@ years ) of both sexes meeting the criteria for Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition , AN ( except for amenorrhea ) were enrolled .", "sentence_id": 7}
+{"abstract_id": "25250660", "label": "methods", "text": "Three participants were withdrawn from FBT and @ were withdrawn from SyFT after serious adverse events occurred .", "sentence_id": 8}
+{"abstract_id": "25250660", "label": "methods", "text": "Two manualized family therapies with @ one-hour sessions during @ months .", "sentence_id": 9}
+{"abstract_id": "25250660", "label": "methods", "text": "Family-based therapy focuses on the facilitation of weight gain , whereas SyFT addresses general family processes .", "sentence_id": 10}
+{"abstract_id": "25250660", "label": "methods", "text": "The primary outcomes were percentage of ideal body weight ( IBW ) and remission ( @ % of IBW ) .", "sentence_id": 11}
+{"abstract_id": "25250660", "label": "methods", "text": "The a priori hypothesis was that FBT would result in faster weight gain early in treatment and at the end of treatment ( EOT ) .", "sentence_id": 12}
+{"abstract_id": "25250660", "label": "results", "text": "There were no statistically significant differences between treatment groups for the primary outcome , for eating disorder symptoms or comorbid psychiatric disorders at the EOT or follow-up .", "sentence_id": 13}
+{"abstract_id": "25250660", "label": "results", "text": "Remission rates included FBT , @ % at the EOT and @ % at follow-up and SyFT , @ % and @ % , respectively .", "sentence_id": 14}
+{"abstract_id": "25250660", "label": "results", "text": "Family-based therapy led to significantly faster weight gain early in treatment , significantly fewer days in the hospital , and lower treatment costs per patient in remission at the EOT ( FBT , $ @ ; SyFT , $ @ ) .", "sentence_id": 15}
+{"abstract_id": "25250660", "label": "results", "text": "An exploratory moderator analysis found that SyFT led to greater weight gain than did FBT for participants with more severe obsessive-compulsive symptoms .", "sentence_id": 16}
+{"abstract_id": "25250660", "label": "conclusions", "text": "The findings of this study suggest that FBT is the preferred treatment for adolescent AN because it is not significantly different from SyFT and leads to similar outcomes at a lower cost than SyFT .", "sentence_id": 17}
+{"abstract_id": "25250660", "label": "conclusions", "text": "Adolescents with more severe obsessive-compulsive symptoms may receive more benefits with SyFT .", "sentence_id": 18}
+{"abstract_id": "24279284", "label": "background", "text": "The aim of the present study was to assess the efficacy of structured education in insulin-treated type @ diabetes mellitus ( T@DM ) patients .", "sentence_id": 0}
+{"abstract_id": "24279284", "label": "methods", "text": "In a @-week open-label randomized controlled study , @ T@DM patients with inadequate responses to two or more oral antidiabetic drugs ( OADs ) for > @ months ( HbA@c > @ % ) were randomized ( @:@ ) to either an education group ( structured diabetes education plus insulin therapy ) or a control group ( usual care plus insulin therapy ) .", "sentence_id": 1}
+{"abstract_id": "24279284", "label": "methods", "text": "Both groups discontinued previous OADs ( except biguanides and - glucosidase inhibitors ) and started twice daily injections of @ % soluble-@ % isophane recombinant insulin .", "sentence_id": 2}
+{"abstract_id": "24279284", "label": "methods", "text": "The primary endpoint was the change in HbA@c from baseline .", "sentence_id": 3}
+{"abstract_id": "24279284", "label": "methods", "text": "Efficacy and safety data were analyzed for within - and between-group differences .", "sentence_id": 4}
+{"abstract_id": "24279284", "label": "results", "text": "Of the initial @ patients , @ completed the study ( @ in the control group ; @ in the education group ) .", "sentence_id": 5}
+{"abstract_id": "24279284", "label": "results", "text": "At the end of the study , significant reductions in HbA@c versus baseline were evident in both groups , but the reduction was greater in the education group ( @ % vs. @ % ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24279284", "label": "results", "text": "A higher proportion of patients in the education group achieved target HbA@c levels < @ % ( @ % vs. @ % ; P < @ ) and @ % ( @ % vs. @ % ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24279284", "label": "results", "text": "In addition , patients in the education group showed greater increments in scores and improvement in the Morisky Medication Adherence Scale ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24279284", "label": "results", "text": "The overall incidence of hypoglycemic events was similar in the two groups .", "sentence_id": 9}
+{"abstract_id": "24279284", "label": "conclusions", "text": "Structured education can promote the ability of patients to self-manage and their compliance with medications , thereby achieving better outcomes .", "sentence_id": 10}
+{"abstract_id": "24461364", "label": "objective", "text": "The present study is a comparison of two point-of-care ( POC ) tests as endpoints of protamine titration after CPB .", "sentence_id": 0}
+{"abstract_id": "24461364", "label": "objective", "text": "The authors hypothesized that using the heparinase-kaolin thromboelastography ( TEG-HK ) R-time difference would more readily identify residual heparin necessitating additional protamine than when using activated coagulation time ( ACT ) .", "sentence_id": 1}
+{"abstract_id": "24461364", "label": "objective", "text": "The primary endpoint was the between-group difference in protamine dose .", "sentence_id": 2}
+{"abstract_id": "24461364", "label": "objective", "text": "Whether this approach would lessen postoperative bleeding and sequelae also was investigated .", "sentence_id": 3}
+{"abstract_id": "24461364", "label": "methods", "text": "Single center , blinded , prospective , randomized study .", "sentence_id": 4}
+{"abstract_id": "24461364", "label": "methods", "text": "University teaching hospital .", "sentence_id": 5}
+{"abstract_id": "24461364", "label": "methods", "text": "Eighty-two adult patients for on-pump coronary artery bypass and/or valve surgery .", "sentence_id": 6}
+{"abstract_id": "24461364", "label": "methods", "text": "Patients were randomized .", "sentence_id": 7}
+{"abstract_id": "24461364", "label": "methods", "text": "In the ACT group , protamine was titrated until ACT did not exceed baseline by more than @ % .", "sentence_id": 8}
+{"abstract_id": "24461364", "label": "methods", "text": "In the TEG group , a TEG-HK R-time difference less than @ % was targeted .", "sentence_id": 9}
+{"abstract_id": "24461364", "label": "methods", "text": "Protamine was repeated to achieve the endpoints .", "sentence_id": 10}
+{"abstract_id": "24461364", "label": "methods", "text": "Clinicians in the ACT group were blinded to TEG data and vice versa .", "sentence_id": 11}
+{"abstract_id": "24461364", "label": "results", "text": "There was no between-group difference in total protamine dose ( @ @ and @ @ ; @ % CI of the difference between means : -@ to @ mg/kg ; p = @ ) or protamine : heparin ratios ( @:@ and @:@ ; @ % CI of the difference between means : -@ to @ mg/mg ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24461364", "label": "results", "text": "In the ACT group , @ % of patients required a second protamine dose , and in the TEG group , @ % of patients required a second protamine dose .", "sentence_id": 13}
+{"abstract_id": "24461364", "label": "results", "text": "No between-group differences in the postoperative transfusion requirements or intensive care unit length of stay were demonstrated .", "sentence_id": 14}
+{"abstract_id": "24461364", "label": "conclusions", "text": "No difference was identified in protamine dosing using either ACT or TEG-HK R-time difference as endpoints .", "sentence_id": 15}
+{"abstract_id": "24461364", "label": "conclusions", "text": "Heparinase TEG may be useful for monitoring heparin reversal .", "sentence_id": 16}
+{"abstract_id": "24830716", "label": "background", "text": "Clinical practice guidelines are considered important instruments to improve quality of care .", "sentence_id": 0}
+{"abstract_id": "24830716", "label": "background", "text": "However , success is dependent on adherence , which may be improved using peer assessment , a strategy in which professionals assess performance of their peers in a simulated setting .", "sentence_id": 1}
+{"abstract_id": "24830716", "label": "objective", "text": "The aim of this study was to determine whether peer assessment is more effective than case-based discussions to improve knowledge and guideline-consistent clinical reasoning in the Dutch physical therapy guideline for low back pain ( LBP ) .", "sentence_id": 2}
+{"abstract_id": "24830716", "label": "methods", "text": "A cluster randomized controlled trial was conducted .", "sentence_id": 3}
+{"abstract_id": "24830716", "label": "methods", "text": "Ten communities of practice ( CoPs ) of physical therapists were cluster randomized ( N = @ ) : @ CoPs in the peer-assessment group ( n = @ ) and @ CoPs in the case-based discussion group ( control group ) ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24830716", "label": "methods", "text": "Both groups participated in @ educational sessions and used clinical patient cases .", "sentence_id": 5}
+{"abstract_id": "24830716", "label": "methods", "text": "The peer-assessment group reflected on performed LBP management in different roles .", "sentence_id": 6}
+{"abstract_id": "24830716", "label": "methods", "text": "The control group used structured discussions .", "sentence_id": 7}
+{"abstract_id": "24830716", "label": "methods", "text": "Outcomes were assessed at baseline and at @ months .", "sentence_id": 8}
+{"abstract_id": "24830716", "label": "methods", "text": "The primary outcome measure was knowledge and guideline-consistent reasoning , measured with @ performance indicators using @ vignettes with specific guideline-related patient profiles .", "sentence_id": 9}
+{"abstract_id": "24830716", "label": "methods", "text": "For each participant , the total score was calculated by adding up the percentage scores ( @-@ ) per vignette , divided by @ .", "sentence_id": 10}
+{"abstract_id": "24830716", "label": "methods", "text": "The secondary outcome measure was reflective practice , as measured by the Self-Reflection and Insight Scale ( @-@ ) .", "sentence_id": 11}
+{"abstract_id": "24830716", "label": "results", "text": "Vignettes were completed by @ participants ( @ % ) .", "sentence_id": 12}
+{"abstract_id": "24830716", "label": "results", "text": "Multilevel analysis showed an increase in guideline-consistent clinical reasoning of @ % in the peer-assessment group , whereas the control group showed a decline of @ % ( estimated group difference = @ % , @ % confidence interval = @ to @ ) .", "sentence_id": 13}
+{"abstract_id": "24830716", "label": "results", "text": "No group differences were found on self-reflection .", "sentence_id": 14}
+{"abstract_id": "24830716", "label": "conclusions", "text": "The small sample size , a short-term follow-up , and the use of vignettes as a proxy for behavior were limitations of the study .", "sentence_id": 15}
+{"abstract_id": "24830716", "label": "conclusions", "text": "Peer assessment leads to an increase in knowledge and guideline-consistent clinical reasoning .", "sentence_id": 16}
+{"abstract_id": "25781193", "label": "background", "text": "Eczema is one of the most common chronic inflammatory skin diseases , affecting about @ % of children .", "sentence_id": 0}
+{"abstract_id": "25781193", "label": "background", "text": "The pathogenic mechanisms of eczema are still not fully understood , and current treatment of moderate-severe eczema is often difficult .", "sentence_id": 1}
+{"abstract_id": "25781193", "label": "background", "text": "Recently , it has been suggested that Vitamin D plays a key role in this disease , even if mechanisms are only partially known .", "sentence_id": 2}
+{"abstract_id": "25781193", "label": "objective", "text": "The purpose of our study was to assess the @-Hydroxyvitamin D serum levels in a pediatric population suffering from chronic eczema ( IgE-mediated and non-IgE-mediated ) , and to correlate these phenotypes with the SCORAD severity and selected clinical and biological parameters .", "sentence_id": 3}
+{"abstract_id": "25781193", "label": "objective", "text": "Moreover , we aimed to evaluate whether a supplementation of Vitamin D@ could affect the same clinical and laboratory parameters .", "sentence_id": 4}
+{"abstract_id": "25781193", "label": "methods", "text": "@ children with chronic eczema were enrolled in the study .", "sentence_id": 5}
+{"abstract_id": "25781193", "label": "methods", "text": "Severity of eczema was assessed with the SCORAD index .", "sentence_id": 6}
+{"abstract_id": "25781193", "label": "methods", "text": "Past and present history was taken , and patients were divided into two groups according to the state of sensitization .", "sentence_id": 7}
+{"abstract_id": "25781193", "label": "methods", "text": "According to a randomization schedule , the enrolled children were assigned to the following groups : supplementation group , which received a daily oral Vitamin D@ supplementation ( @ IUs ) for @ months ; control group which received no supplementation .", "sentence_id": 8}
+{"abstract_id": "25781193", "label": "results", "text": "Vitamin D concentrations in patients with moderate and severe eczema were not statistically different from Vitamin D concentration detected in the serum of patients with mild eczema .", "sentence_id": 9}
+{"abstract_id": "25781193", "label": "results", "text": "Furthermore , we did not find any correlation between Vitamin D levels , total IgEs and SCORAD index , both in the Sensitized and in the Not-Sensitized group .", "sentence_id": 10}
+{"abstract_id": "25781193", "label": "results", "text": "The Vitamin D@ supplementation did not influence the SCORAD severity or the total IgEs concentration .", "sentence_id": 11}
+{"abstract_id": "25781193", "label": "conclusions", "text": "To our knowledge , our study is the first one that shows no correlation between serum levels of Vitamin D , eczema severity and IgE sensitization in a pediatric population suffering from chronic eczema .", "sentence_id": 12}
+{"abstract_id": "25444222", "label": "background", "text": "Up to @ % of severely injured patients develop trauma-induced coagulopathy .", "sentence_id": 0}
+{"abstract_id": "25444222", "label": "background", "text": "To study interventions for this vulnerable population for whom consent can not be obtained easily , the Food and Drug Administration issued regulations for emergency research with an exception from informed consent ( ER-EIC ) .", "sentence_id": 1}
+{"abstract_id": "25444222", "label": "background", "text": "We describe the community consultation and public disclosure ( CC/PD ) process in preparation for an ER-EIC study , namely the Control Of Major Bleeding After Trauma ( COMBAT ) study .", "sentence_id": 2}
+{"abstract_id": "25444222", "label": "methods", "text": "The CC/PD was guided by the four bioethical principles .", "sentence_id": 3}
+{"abstract_id": "25444222", "label": "methods", "text": "We used a multimedia approach , including one-way communications ( newspaper ads , brochures , television , radio , and web ) and two-way communications ( interactive in-person presentations at community meetings , printed and online feedback forms ) to reach the trials catchment area ( Denver County 's population : @,@ and the Denver larger metro area where commuters reside : @ million ) .", "sentence_id": 4}
+{"abstract_id": "25444222", "label": "methods", "text": "Particular attention was given to special-interests groups ( eg , Jehovah Witnesses , homeless ) and to Spanish-speaking communities ( brochures and presentations in Spanish ) .", "sentence_id": 5}
+{"abstract_id": "25444222", "label": "methods", "text": "Opt-out materials were available during on-site presentations or via the COMBAT study website .", "sentence_id": 6}
+{"abstract_id": "25444222", "label": "results", "text": "A total of @ community organizations were contacted .", "sentence_id": 7}
+{"abstract_id": "25444222", "label": "results", "text": "Brochures were distributed to @ medical clinics and @ homeless shelters .", "sentence_id": 8}
+{"abstract_id": "25444222", "label": "results", "text": "The multimedia campaign had the potential to reach an estimated audience of @ million individuals in large metro Denver area , the majority via one-way communication and @ in two-way communications .", "sentence_id": 9}
+{"abstract_id": "25444222", "label": "results", "text": "This resource intensive process cost more than $ @,@ .", "sentence_id": 10}
+{"abstract_id": "25444222", "label": "conclusions", "text": "The CC/PD process is resource-intensive , costly , and complex .", "sentence_id": 11}
+{"abstract_id": "25444222", "label": "conclusions", "text": "Although the multimedia CC/PD reached a large audience , the effectiveness of this process remains elusive .", "sentence_id": 12}
+{"abstract_id": "25444222", "label": "conclusions", "text": "The templates can be helpful to similar ER-EIC studies .", "sentence_id": 13}
+{"abstract_id": "25417403", "label": "objective", "text": "To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji ( CV @ ) and Guanyuan ( CV @ ) for preventing dysuria after internal fixation of lower limb fractures .", "sentence_id": 0}
+{"abstract_id": "25417403", "label": "methods", "text": "Sixty patients conforming to the inclusion standards were randomly divided into a treatment group ( n = @ ) and a control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25417403", "label": "methods", "text": "Fuzi-cake-separated moxibustion was performed at Guanyuan ( CV @ ) and Zhongji ( CV @ ) , @ min at a time , twice a day , for @ days before operation in the treatment group .", "sentence_id": 2}
+{"abstract_id": "25417403", "label": "methods", "text": "No fuzi-cake-separated moxibustion was performed in the control group .", "sentence_id": 3}
+{"abstract_id": "25417403", "label": "methods", "text": "After treatment , the score for symptoms of first urination , urinary time , urinary volume , @ h remaining urinary volume , incidence of uroschesis , and rate of controlling dysuria were compared to evaluate the curative effect of preventing post-operative dysuria .", "sentence_id": 4}
+{"abstract_id": "25417403", "label": "results", "text": "The score for symptoms of first urination , @ h remaining urinary volume ( maximum @ mL vs @ ml , and less than @ ml in @ cases vs @ cases ) , and the rate of controlling dysuria ( @ % vs @ % ) were significantly better ( P < @ , P < @ , and P < @ , respectively ) in the treatment compared with the control group .", "sentence_id": 5}
+{"abstract_id": "25417403", "label": "results", "text": "There was no statistical difference ( P > @ ) between the two groups in first post-operative urinary time , urinary volume , or incidence of @ h uroschesis .", "sentence_id": 6}
+{"abstract_id": "25417403", "label": "conclusions", "text": "Fuzi-cake-separated moxibustion at Zhongji ( CV @ ) and Guanyuan ( CV @ ) can better prevent post-operative dysuria , effectively promote the functional restoration of the urinary bladder , and control the incidence of post-operative dysuria .", "sentence_id": 7}
+{"abstract_id": "24628859", "label": "background", "text": "Chronic angina is a profoundly symptomatic disease .", "sentence_id": 0}
+{"abstract_id": "24628859", "label": "background", "text": "We evaluated the relationship between angina frequency and health utility .", "sentence_id": 1}
+{"abstract_id": "24628859", "label": "methods", "text": "We used data from stable angina patients reporting @ attacks/week enrolled in the Efficacy of Ranolazine in Chronic Angina ( ERICA ) trial .", "sentence_id": 2}
+{"abstract_id": "24628859", "label": "methods", "text": "Angina frequency was classified using the Seattle Angina Questionnaire angina frequency ( SAQAF ) domain into no ( @ ) ; monthly ( @-@ ) ; weekly ( @-@ ) ; and daily ( @-@ ) angina .", "sentence_id": 3}
+{"abstract_id": "24628859", "label": "methods", "text": "EuroQol ( EQ ) -@ D health utility scores were derived from SAQ data using two mapping equations .", "sentence_id": 4}
+{"abstract_id": "24628859", "label": "methods", "text": "Median EQ-@D utility scores for each SAQAF classification after the @-week trial period were calculated ( reported as : Equation @/Equation @ ) .", "sentence_id": 5}
+{"abstract_id": "24628859", "label": "methods", "text": "Changes in EQ-@D utility scores from baseline to end-of-trial for patients achieving and not achieving a @-point improvement in SAQAF score and improving and not improving @ SAQAF classification were compared .", "sentence_id": 6}
+{"abstract_id": "24628859", "label": "results", "text": "Median EQ-@D utility scores ( n = @ ) were @ / @ .", "sentence_id": 7}
+{"abstract_id": "24628859", "label": "results", "text": "Compared to patients reporting no angina symptoms ( n = @ ; @ / @ ) patients reporting monthly ( n = @ ; @ / @ ) , weekly ( n = @ ; @ / @ ) and daily ( n = @ ; @ / @ ) symptoms had poorer health utility ( p < @ for both equations ) .", "sentence_id": 8}
+{"abstract_id": "24628859", "label": "results", "text": "Patients improving @SAQAF classification ( n = @/@ , @ % ) experienced a median @ / @ greater improvement in EQ-@D health utility compared to those not improving @ classification ( p < @ for both equations ) .", "sentence_id": 9}
+{"abstract_id": "24628859", "label": "results", "text": "Patients improving @-points on the SAQAF ( n = @/@ , @ % ) experienced a median @ / @ greater improvement in health utility compared to those not achieving a @-point improvement ( p < @ for both ) .", "sentence_id": 10}
+{"abstract_id": "24628859", "label": "conclusions", "text": "Chronic angina patient health utility decreases as angina frequency increases .", "sentence_id": 11}
+{"abstract_id": "24628859", "label": "conclusions", "text": "Patients reporting clinically important improvement in angina frequency experience a tangible improvement in health utility .", "sentence_id": 12}
+{"abstract_id": "25420431", "label": "background", "text": "Patients with bipolar disorder often show decreased adherence with mood stabilizers and frequently interventions on prodromal depressive and manic symptoms are delayed .", "sentence_id": 0}
+{"abstract_id": "25420431", "label": "background", "text": "Recently , the MONARCA I randomized controlled trial investigated the effect of electronic self-monitoring using smartphones on depressive and manic symptoms .", "sentence_id": 1}
+{"abstract_id": "25420431", "label": "background", "text": "The findings suggested that patients using the MONARCA system had more sustained depressive symptoms than patients using a smartphone for normal communicative purposes , but had fewer manic symptoms during the trial .", "sentence_id": 2}
+{"abstract_id": "25420431", "label": "background", "text": "It is likely that the ability of these self-monitored measures to detect prodromal symptoms of depression and mania may be insufficient compared to automatically generated objective data on measures of illness activity such as phone usage , social activity , physical activity , and mobility .", "sentence_id": 3}
+{"abstract_id": "25420431", "label": "background", "text": "The Monsenso system , for smartphones integrating subjective and objective measures of illness activity was developed and will be tested in the present trial .", "sentence_id": 4}
+{"abstract_id": "25420431", "label": "methods", "text": "The MONARCA II trial uses a randomized controlled single-blind parallel-group design .", "sentence_id": 5}
+{"abstract_id": "25420431", "label": "methods", "text": "Patients with bipolar disorder according to ICD-@ who previously have been treated at the Copenhagen Clinic for Affective Disorder , Denmark are included and randomized to either daily use of the Monsenso system including an feedback loop between patients and clinicians ( the intervention group ) or to the use of a smartphone for normal communicative purposes ( the control group ) for a @-month trial period .", "sentence_id": 6}
+{"abstract_id": "25420431", "label": "methods", "text": "The trial was started in September @ and recruitment is ongoing .", "sentence_id": 7}
+{"abstract_id": "25420431", "label": "methods", "text": "The outcomes are : differences in depressive and manic symptoms ; rate of depressive and manic episodes ( primary ) ; automatically generated objective data on measures of illness activity ; number of days hospitalized ; psychosocial functioning ( secondary ) ; perceived stress ; quality of life ; self-rated depressive symptoms ; self-rated manic symptoms ; recovery ; empowerment and adherence to medication ( tertiary ) between the intervention group and the control group during the trial .", "sentence_id": 8}
+{"abstract_id": "25420431", "label": "methods", "text": "Ethical permission has been obtained .", "sentence_id": 9}
+{"abstract_id": "25420431", "label": "methods", "text": "Positive , neutral and negative findings will be published .", "sentence_id": 10}
+{"abstract_id": "25420431", "label": "conclusions", "text": "If the system is effective in reducing depressive and/or manic symptoms ( and other symptoms of bipolar disorder ) and the rate of episodes , there will be basis for extending the use to the treatment of bipolar disorder in general and in larger scale .", "sentence_id": 11}
+{"abstract_id": "24996379", "label": "objective", "text": "There are scarce data regarding the impact of sphincterotome design on cannulation success .", "sentence_id": 0}
+{"abstract_id": "24996379", "label": "objective", "text": "We aimed to compare two different @ Fr standard sphincterotomes to determine initial cannulation success .", "sentence_id": 1}
+{"abstract_id": "24996379", "label": "methods", "text": "Adult patients with naive papillae were enrolled in a prospective , randomized , crossover study .", "sentence_id": 2}
+{"abstract_id": "24996379", "label": "methods", "text": "Two different @ Fr sphincterotomes preloaded with guidewire ( GW ) were used in two groups with @ patients included per group .", "sentence_id": 3}
+{"abstract_id": "24996379", "label": "methods", "text": "A total of five papillary attempts and two pancreatic channel entries were allowed as maximum targets .", "sentence_id": 4}
+{"abstract_id": "24996379", "label": "methods", "text": "In a case of more than two pancreatic entries , a double GW technique was attempted before crossover .", "sentence_id": 5}
+{"abstract_id": "24996379", "label": "methods", "text": "If choledochal cannulation was not achieved within ten papillary attempts or more than four pancreatic entries despite crossover , access papillotomy was performed .", "sentence_id": 6}
+{"abstract_id": "24996379", "label": "methods", "text": "Successful biliary cannulation was the primary outcome .", "sentence_id": 7}
+{"abstract_id": "24996379", "label": "methods", "text": "Secondary outcomes were incidence of early complications and overall cannulation success .", "sentence_id": 8}
+{"abstract_id": "24996379", "label": "results", "text": "Higher initial cannulation success was achieved in group I compared with group II ( @ vs. @ % , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24996379", "label": "results", "text": "The crossover and double GW techniques reduced the need for precut from @ to @ % .", "sentence_id": 10}
+{"abstract_id": "24996379", "label": "results", "text": "The overall cannulation success including precut for failed cases was @ % ( group I ) and @ % ( group II ) .", "sentence_id": 11}
+{"abstract_id": "24996379", "label": "results", "text": "Sphincterotome type , presence of crossover , and number of cannulation attempts were predictors of successful cannulation in multivariate analysis .", "sentence_id": 12}
+{"abstract_id": "24996379", "label": "conclusions", "text": "There was a significant difference in cannulation success between two different @ Fr sphincterotomes .", "sentence_id": 13}
+{"abstract_id": "24996379", "label": "conclusions", "text": "The cannulation success was mainly governed by sphincterotome design which serves a proper spatial orientation during the procedure .", "sentence_id": 14}
+{"abstract_id": "24996379", "label": "conclusions", "text": "The combined use of crossover and double GW techniques may substantially decrease precut necessity .", "sentence_id": 15}
+{"abstract_id": "24239213", "label": "background", "text": "Providing written medicine information to consumers enables them to make informed decisions about their medicines , playing an important role in educating and improving health literacy .", "sentence_id": 0}
+{"abstract_id": "24239213", "label": "background", "text": "In Australia , standardized written medicine information called Consumer Medicine Information ( CMI ) is available for medicines as package inserts , computer prints , or leaflets .", "sentence_id": 1}
+{"abstract_id": "24239213", "label": "background", "text": "Consumers want and read CMI , but may not always ask for it .", "sentence_id": 2}
+{"abstract_id": "24239213", "label": "background", "text": "General practitioners ( GPs ) and pharmacists are an important source of written medicine information , yet may not always provide CMI in their practice .", "sentence_id": 3}
+{"abstract_id": "24239213", "label": "objective", "text": "To examine and compare the awareness , use and provision of CMI by consumers , pharmacists and general practitioners ( GPs ) .", "sentence_id": 4}
+{"abstract_id": "24239213", "label": "methods", "text": "Based on previous studies , structured questionnaires were developed and administered to a national sample of consumers ( phone survey ) ; community pharmacists and GPs ( postal surveys ) about utilization of CMI .", "sentence_id": 5}
+{"abstract_id": "24239213", "label": "methods", "text": "Descriptive , comparative and logistic regression analyses were conducted .", "sentence_id": 6}
+{"abstract_id": "24239213", "label": "results", "text": "The respondents comprised of @ pharmacists , @ GPs and @ consumers .", "sentence_id": 7}
+{"abstract_id": "24239213", "label": "results", "text": "Two-thirds of consumers , nearly all ( @ % ) pharmacists and @ % of GPs were aware of CMI .", "sentence_id": 8}
+{"abstract_id": "24239213", "label": "results", "text": "About @ % of consumers reported receiving CMI as a package insert , however most pharmacists ( @ % ) and GPs ( @ % ) reported providing computer-generated CMI .", "sentence_id": 9}
+{"abstract_id": "24239213", "label": "results", "text": "GPs ' and pharmacists ' main reason for providing CMI was on patient request .", "sentence_id": 10}
+{"abstract_id": "24239213", "label": "results", "text": "Reasons for not providing were predominantly because consumers were already taking the medicine , concerns regarding difficulty understanding the information , or potential non-adherence .", "sentence_id": 11}
+{"abstract_id": "24239213", "label": "results", "text": "Of the @ consumers reportedly reading CMI , @ % indicated concerns after reading .", "sentence_id": 12}
+{"abstract_id": "24239213", "label": "results", "text": "Factors associated with reading included gender , type of CMI received and frequency of provision .", "sentence_id": 13}
+{"abstract_id": "24239213", "label": "conclusions", "text": "Consumers want and read information about their medicines , especially when received from their GP or pharmacist .", "sentence_id": 14}
+{"abstract_id": "24239213", "label": "conclusions", "text": "Healthcare professionals report usually discussing CMI when providing it to patients , although continued improvements in dissemination rates are desirable .", "sentence_id": 15}
+{"abstract_id": "24239213", "label": "conclusions", "text": "Regular use of CMI remains a challenge , and ongoing strategies to promote CMI use are necessary to improve uptake of CMI in Australia .", "sentence_id": 16}
+{"abstract_id": "24872002", "label": "objective", "text": "The aim of this study was to compare the contrast-to-noise ratio ( CNR ) values of infarct and remote myocardium as well as infarct and blood after application of @ mmol/kg gadobutrol and @ mmol/kg gadobenate dimeglumine on late gadolinium enhancement magnetic resonance ( MR ) images .", "sentence_id": 0}
+{"abstract_id": "24872002", "label": "methods", "text": "The study was a prospective randomized controlled clinical study .", "sentence_id": 1}
+{"abstract_id": "24872002", "label": "methods", "text": "After informed consent was obtained , @ patients ( @ men , @ women ; mean age , @ @ years ) with known chronic myocardial infarction were included for an intraindividual comparison of a single-dose gadobutrol and a single-dose gadobenate dimeglumine .", "sentence_id": 2}
+{"abstract_id": "24872002", "label": "methods", "text": "Two MR imaging examinations were performed within a period of @ days in a crossover design .", "sentence_id": 3}
+{"abstract_id": "24872002", "label": "methods", "text": "Late gadolinium enhancement imaging was performed @ minutes after gadolinium administration using a @-dimensional phase-sensitive inversion recovery gradient echo sequence at @ T. Infarct size , signal intensities ( SIs ) , signal-to-noise ratio , and CNR were determined on phase-sensitive MR images .", "sentence_id": 4}
+{"abstract_id": "24872002", "label": "methods", "text": "Values for CNR were calculated as CNRinfarct/myocardium = ( SIinfarct - SImyocardium ) / SDnoise and CNRinfarct/blood = ( SIinfarct - SIblood ) / SDnoise .", "sentence_id": 5}
+{"abstract_id": "24872002", "label": "methods", "text": "In addition , the areas of myocardial infarction were determined on single slices .", "sentence_id": 6}
+{"abstract_id": "24872002", "label": "methods", "text": "The entire infarct volumes were calculated by adding the areas with hyperenhancement multiplied by the slice thickness .", "sentence_id": 7}
+{"abstract_id": "24872002", "label": "results", "text": "Late gadolinium enhancement was present in all patients .", "sentence_id": 8}
+{"abstract_id": "24872002", "label": "results", "text": "Median values of the infarct area , infarct volume , and transmurality for gadobutrol and gadobenate dimeglumine showed good to excellent concordance ( rc = @ , rc = @ , and rc = @ , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24872002", "label": "results", "text": "The mean signal-to-noise ratio values for infarct , remote myocardium , and ventricular blood were @ @ , @ @ , and @ @ , respectively , for gadobutrol and @ @ , @ @ , and @ @ , respectively , for gadobenate dimeglumine ( P = @ , P = @ , and P = @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "24872002", "label": "results", "text": "The mean values of CNRinfarct/myocardium and CNRinfarct/blood were @ @ and @ @ , respectively , for gadobutrol and @ @ and @ @ , respectively , for gadobenate dimeglumine ( P = @ and P = @ , respectively ) .", "sentence_id": 11}
+{"abstract_id": "24872002", "label": "conclusions", "text": "Both gadobutrol and gadobenate dimeglumine allow for successful late gadolinium enhancement imaging of chronic myocardial infarction after a single-dose application ( @ mmol/kg ) at @ T. Gadobutrol provides a higher CNR between infarct and blood .", "sentence_id": 12}
+{"abstract_id": "24872002", "label": "conclusions", "text": "The CNRs between infarct and normal myocardium , infarct size , and transmural extent were similar for both contrast agents .", "sentence_id": 13}
+{"abstract_id": "24956453", "label": "objective", "text": "Patients undergoing breast cancer surgery frequently experience chronic postoperative pain .", "sentence_id": 0}
+{"abstract_id": "24956453", "label": "objective", "text": "The primary objective of this randomized study was to determine if thoracic paravertebral block ( TPVB ) reduced the incidence of chronic pain after a modified radical mastectomy ( MRM ) when compared with general anesthesia ( GA ) .", "sentence_id": 1}
+{"abstract_id": "24956453", "label": "methods", "text": "One hundred eighty women undergoing MRM were randomized to @ of @ study groups : group @ : standardized GA , group @ : GA with a single-injection TPVB and placebo paravertebral infusion , and group @ : GA with a continuous TPVB .", "sentence_id": 2}
+{"abstract_id": "24956453", "label": "methods", "text": "Outcomes assessed postoperatively included acute postoperative pain and analgesic consumption and , at @ and @ months , the incidence and severity of chronic pain and physical and mental health-related quality of life ( HRQOL ) .", "sentence_id": 3}
+{"abstract_id": "24956453", "label": "results", "text": "There was no significant difference in the incidence of chronic pain at @ months ( P = @ ) and @ months ( P = @ ) after the MRM between the study groups .", "sentence_id": 4}
+{"abstract_id": "24956453", "label": "results", "text": "The relative risk of developing chronic pain ( P = @ ) was also similar between the groups .", "sentence_id": 5}
+{"abstract_id": "24956453", "label": "results", "text": "There was no difference in acute pain ( P = @ ) or postoperative analgesic consumption ( P = @ ) between the groups .", "sentence_id": 6}
+{"abstract_id": "24956453", "label": "results", "text": "Nevertheless , differences were observed in chronic pain-related secondary outcome variables .", "sentence_id": 7}
+{"abstract_id": "24956453", "label": "results", "text": "The TPVB groups reported lower chronic pain scores ( P < @ ) , exhibited fewer symptoms and signs of chronic pain ( P @ ) , and also experienced better physical and mental HRQOL than did the GA group .", "sentence_id": 8}
+{"abstract_id": "24956453", "label": "results", "text": "Chronic pain scores also decreased with time in all study groups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24956453", "label": "conclusions", "text": "There is no significant difference in the incidence or relative risk of chronic pain at @ and @ months after an MRM when TPVB is used in conjunction with GA. .", "sentence_id": 10}
+{"abstract_id": "24956453", "label": "conclusions", "text": "Nevertheless , patients who receive a TPVB report less severe chronic pain , exhibit fewer symptoms and signs of chronic pain , and also experience better physical and mental HRQOL .", "sentence_id": 11}
+{"abstract_id": "25927297", "label": "background", "text": "Narrative exposure therapy ( NET ) is a brief , manualised treatment for Posttraumatic Stress Disorder ( PTSD ) .", "sentence_id": 0}
+{"abstract_id": "25927297", "label": "background", "text": "It has been shown to have therapeutic benefits for a wide range of individuals and settings .", "sentence_id": 1}
+{"abstract_id": "25927297", "label": "background", "text": "This study , following our previous work applying the original NET in earthquake survivors , aimed to revise NET to be adaptable for treating PTSD after a natural disaster .", "sentence_id": 2}
+{"abstract_id": "25927297", "label": "methods", "text": "A randomised waiting-list controlled study was conducted with @ adult participants with PTSD who were randomly allocated to NET ( n = @ ) , revised NET ( NET-R ; n = @ ) or a waiting list condition ( WL ; n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25927297", "label": "methods", "text": "Participants in NET and NET-R received treatment immediately ; those in the WL condition received NET-R treatment after a waiting period .", "sentence_id": 4}
+{"abstract_id": "25927297", "label": "methods", "text": "All groups were assessed on PTSD , general distress , anxiety , depression , social support , coping and posttraumatic change before and after treatment and three-month follow-up .", "sentence_id": 5}
+{"abstract_id": "25927297", "label": "results", "text": "Compared with WL , both NET and NET-R groups showed significant reductions in PTSD and related symptoms .", "sentence_id": 6}
+{"abstract_id": "25927297", "label": "results", "text": "Significant increases were found in posttraumatic growth , active coping and perceived social support .", "sentence_id": 7}
+{"abstract_id": "25927297", "label": "results", "text": "The WL group showed similar improvements after treatment .", "sentence_id": 8}
+{"abstract_id": "25927297", "label": "results", "text": "Further reductions on PTSD symptoms were found at three months , showing that NET-R is as effective as the original NET in treating post-earthquake traumatic symptoms in adult Chinese earthquake survivors .", "sentence_id": 9}
+{"abstract_id": "25927297", "label": "conclusions", "text": "NET-R is a feasible and cost-effective intervention for Chinese earthquake survivors .", "sentence_id": 10}
+{"abstract_id": "25927297", "label": "conclusions", "text": "Further studies are needed to replicate these findings in other survivor populations , and with larger samples and over longer periods .", "sentence_id": 11}
+{"abstract_id": "25927297", "label": "conclusions", "text": "This study highlighted the value of oral narrative approach , which is well-accepted and useful in the context of single natural disaster and lower - income area .", "sentence_id": 12}
+{"abstract_id": "24473367", "label": "objective", "text": "The objective of the study was to test the diagnostic performance of low-dose computed tomography pulmonary angiography ( CTPA ) at peak tube voltage of @ kVp with both reduced radiation and reduced contrast material ( CM ) dose .", "sentence_id": 0}
+{"abstract_id": "24473367", "label": "methods", "text": "In this single-center , single-blinded prospective randomized trial , @ patients with body weights of less than @ kg with suspected acute pulmonary embolism ( PE ) were assigned to normal-dose CTPA ( @-kVp tube energy and @-mL CM , @ patients ) and low-dose CTPA ( @-kVp tube energy and @-mL CM , @ patients ) .", "sentence_id": 1}
+{"abstract_id": "24473367", "label": "methods", "text": "Primary end points were evidence of PE in CTPA and accuracy of CTPA on a composite reference standard .", "sentence_id": 2}
+{"abstract_id": "24473367", "label": "methods", "text": "Results were compared by calculating the odds ratio with the @ % confidence interval .", "sentence_id": 3}
+{"abstract_id": "24473367", "label": "results", "text": "The reference diagnosis was equivocal in @ of the @ patients .", "sentence_id": 4}
+{"abstract_id": "24473367", "label": "results", "text": "Diagnosis of CTPA was correct in @ patients and incorrect in @ in the normal-dose group .", "sentence_id": 5}
+{"abstract_id": "24473367", "label": "results", "text": "Computed tomography pulmonary angiography was correct in @ patients and incorrect in @ in the low-dose group ( odds ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24473367", "label": "results", "text": "Sensitivity was @ % and @ % and specificity was @ % and @ % in the normal-dose and low-dose groups , respectively .", "sentence_id": 7}
+{"abstract_id": "24473367", "label": "results", "text": "No PE or PE-related death occurred during the @-day follow-up .", "sentence_id": 8}
+{"abstract_id": "24473367", "label": "results", "text": "The size-specific dose estimates were @ % lower at @ kVp ( @ @ mGy ) compared with that at @ kVp ( @ @ mGy ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24473367", "label": "conclusions", "text": "The accuracy of low-dose CTPA at @ kVp with a @ % reduced radiation dose and a @ % lower CM volume is not significantly different from that of normal-dose CTPA at @ kVp in detecting acute PE in patients weighing less than @ kg .", "sentence_id": 10}
+{"abstract_id": "26143666", "label": "objective", "text": "To evaluate the association of subretinal hyperreflective material ( SHRM ) with visual acuity ( VA ) , geographic atrophy ( GA ) , and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials ( CATT ) .", "sentence_id": 0}
+{"abstract_id": "26143666", "label": "methods", "text": "Prospective cohort study within a randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "26143666", "label": "methods", "text": "The @ CATT participants .", "sentence_id": 2}
+{"abstract_id": "26143666", "label": "methods", "text": "Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain ( SD ) optical coherence tomography ( OCT ) throughout @ weeks .", "sentence_id": 3}
+{"abstract_id": "26143666", "label": "methods", "text": "Measurements of SHRM height and width in the fovea , within the center @ mm ( @ ) , or outside the center @mm ( @ ) were obtained on SD OCT images at @ ( n = @ ) and @ ( n = @ ) weeks .", "sentence_id": 4}
+{"abstract_id": "26143666", "label": "methods", "text": "Presence of SHRM , as well as location and size , and associations with VA , scar , and GA. .", "sentence_id": 5}
+{"abstract_id": "26143666", "label": "results", "text": "Among CATT participants , the percentage with SHRM at enrollment was @ % , decreasing to @ % at @ weeks after treatment and to @ % at @ weeks .", "sentence_id": 6}
+{"abstract_id": "26143666", "label": "results", "text": "At @ weeks , scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved ( @ % vs. @ % ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26143666", "label": "results", "text": "Among eyes with detailed evaluation of SHRM at weeks @ ( n = @ ) and @ ( n = @ ) , mean VA letter score was @ ( standard error -LSB- SE -RSB- , @ ) , @ ( SE , @ ) , @ ( SE , @ ) , and @ ( SE , @ ) when SHRM was absent , present outside the central @ mm ( @ ) , present within the central @ mm ( @ ) but not the foveal center , or present at the foveal center ( P = @ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "26143666", "label": "results", "text": "When SHRM was present , the median maximum height under the fovea , within the central @ mm ( @ ) including the fovea and anywhere within the scan , was @ m , @ m , and @ m , respectively .", "sentence_id": 9}
+{"abstract_id": "26143666", "label": "results", "text": "Visual acuity was decreased with greater SHRM height and width ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "26143666", "label": "conclusions", "text": "In eyes with neovascular age-related macular degeneration ( AMD ) , SHRM is common and often persists after anti-vascular endothelial growth factor treatment .", "sentence_id": 11}
+{"abstract_id": "26143666", "label": "conclusions", "text": "At @ years , eyes with scar were more likely to have SHRM than other eyes .", "sentence_id": 12}
+{"abstract_id": "26143666", "label": "conclusions", "text": "Greater SHRM dimensions were associated with worse VA. .", "sentence_id": 13}
+{"abstract_id": "26143666", "label": "conclusions", "text": "In eyes with neovascular AMD , SHRM is an important morphologic biomarker .", "sentence_id": 14}
+{"abstract_id": "25307295", "label": "background", "text": "A phase @ randomized clinical trial was designed to test whether bardoxolone methyl , a nuclear factor erythroid-@-related factor @ ( Nrf@ ) activator , slows progression to end-stage renal disease in patients with stage @ chronic kidney disease and type @ diabetes mellitus .", "sentence_id": 0}
+{"abstract_id": "25307295", "label": "background", "text": "The trial was terminated because of an increase in heart failure in the bardoxolone methyl group ; many of the events were clinically associated with fluid retention .", "sentence_id": 1}
+{"abstract_id": "25307295", "label": "results", "text": "We randomized @,@ patients with type @ diabetes mellitus ( T@DM ) and stage @ chronic kidney disease ( CKD ) ( estimated glomerular filtration rate @ to < @ mL min ( -@ ) @ m ( -@ ) ) to once-daily bardoxolone methyl ( @ mg ) or placebo .", "sentence_id": 2}
+{"abstract_id": "25307295", "label": "results", "text": "We used classification and regression tree analysis to identify baseline factors predictive of heart failure or fluid overload events .", "sentence_id": 3}
+{"abstract_id": "25307295", "label": "results", "text": "Elevated baseline B-type natriuretic peptide and previous hospitalization for heart failure were identified as predictors of heart failure events ; bardoxolone methyl increased the risk of heart failure by @ % in patients with these risk factors .", "sentence_id": 4}
+{"abstract_id": "25307295", "label": "results", "text": "For patients without these baseline characteristics , the risk for heart failure events among bardoxolone methyl - and placebo-treated patients was similar ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25307295", "label": "results", "text": "The same risk factors were also identified as predictors of fluid overload and appeared to be related to other serious adverse events .", "sentence_id": 6}
+{"abstract_id": "25307295", "label": "conclusions", "text": "Bardoxolone methyl contributed to events related to heart failure and/or fluid overload in a subpopulation of susceptible patients with an increased risk for heart failure at baseline .", "sentence_id": 7}
+{"abstract_id": "25307295", "label": "conclusions", "text": "Careful selection of participants and vigilant monitoring of the study drug will be required in any future trials of bardoxolone methyl to mitigate the risk of heart failure and other serious adverse events .", "sentence_id": 8}
+{"abstract_id": "24247300", "label": "objective", "text": "Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction ; however , neither strategy has been rigorously tested .", "sentence_id": 0}
+{"abstract_id": "24247300", "label": "objective", "text": "To test the @ independent hypotheses that , compared with placebo , addition of low-dose dopamine ( @ g/kg/min ) or low-dose nesiritide ( @ g/kg/min without bolus ) to diuretic therapy will enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction .", "sentence_id": 1}
+{"abstract_id": "24247300", "label": "methods", "text": "Multicenter , double-blind , placebo-controlled clinical trial ( Renal Optimization Strategies Evaluation -LSB- ROSE -RSB- ) of @ hospitalized patients with acute heart failure and renal dysfunction ( estimated glomerular filtration rate of @-@ mL/min/@ @ m@ ) , randomized within @ hours of admission .", "sentence_id": 2}
+{"abstract_id": "24247300", "label": "methods", "text": "Enrollment occurred from September @ to March @ across @ sites in North America .", "sentence_id": 3}
+{"abstract_id": "24247300", "label": "methods", "text": "Participants were randomized in an open , @:@ allocation ratio to the dopamine or nesiritide strategy .", "sentence_id": 4}
+{"abstract_id": "24247300", "label": "methods", "text": "Within each strategy , participants were randomized in a double-blind , @:@ ratio to active treatment or placebo .", "sentence_id": 5}
+{"abstract_id": "24247300", "label": "methods", "text": "The dopamine ( n = @ ) and nesiritide ( n = @ ) groups were independently compared with the pooled placebo group ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24247300", "label": "methods", "text": "Coprimary end points included @-hour cumulative urine volume ( decongestion end point ) and the change in serum cystatin C from enrollment to @ hours ( renal function end point ) .", "sentence_id": 7}
+{"abstract_id": "24247300", "label": "results", "text": "Compared with placebo , low-dose dopamine had no significant effect on @-hour cumulative urine volume ( dopamine , @ mL ; @ % CI , @-@ vs placebo , @ mL ; @ % CI , @-@ ; difference , @ mL ; @ % CI , -@ to @ mL ; P = @ ) or on the change in cystatin C level ( dopamine , @ mg/L ; @ % CI , @-@ @ vs placebo , @ mg/L ; @ % CI , @-@ @ ; difference , @ ; @ % CI , -@ to @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24247300", "label": "results", "text": "Similarly , low-dose nesiritide had no significant effect on @-hour cumulative urine volume ( nesiritide , @ mL ; @ % CI , @-@ vs placebo , @ mL ; @ % CI , @-@ ; difference , @ mL ; @ % CI , -@ to @ mL ; P = @ ) or on the change in cystatin C level ( nesiritide , @ mg/L ; @ % CI , @-@ @ vs placebo , @ mg/L ; @ % CI , @-@ @ ; difference , -@ ; @ % CI , -@ to @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24247300", "label": "results", "text": "Compared with placebo , there was no effect of low-dose dopamine or nesiritide on secondary end points reflective of decongestion , renal function , or clinical outcomes .", "sentence_id": 10}
+{"abstract_id": "24247300", "label": "conclusions", "text": "In participants with acute heart failure and renal dysfunction , neither low-dose dopamine nor low-dose nesiritide enhanced decongestion or improved renal function when added to diuretic therapy .", "sentence_id": 11}
+{"abstract_id": "25130678", "label": "background", "text": "The administration of statins seems to be a promising new avenue in the treatment of patients suffering from major depressive disorder ( MDD ) , though patients suffering from severe MDD remain unstudied in this respect .", "sentence_id": 0}
+{"abstract_id": "25130678", "label": "background", "text": "The aim of the present study was therefore to investigate , in a randomized double-blind clinical trial , the influence of adjuvant atorvastatin on symptoms of depression in patients with MDD .", "sentence_id": 1}
+{"abstract_id": "25130678", "label": "methods", "text": "A total of @ patients suffering from MDD ( mean age : @ years ; @ % males ) received a standard medication of @ mg/d citalopram .", "sentence_id": 2}
+{"abstract_id": "25130678", "label": "methods", "text": "Next , patients were randomly assigned either to the atorvastatin group ( @ mg/d ) or to the placebo group .", "sentence_id": 3}
+{"abstract_id": "25130678", "label": "methods", "text": "Blood lipid values were assessed at baseline and on completion of the study @ weeks later .", "sentence_id": 4}
+{"abstract_id": "25130678", "label": "methods", "text": "Experts rated depressive symptoms via Hamilton Depression Rating Scales ( HDRS ) at baseline and @ , @ and @ weeks later .", "sentence_id": 5}
+{"abstract_id": "25130678", "label": "results", "text": "HDRS scores decreased over time ; the significant Time by Group interaction showed that symptoms of depression decreased more in the atorvastatin than in the placebo group .", "sentence_id": 6}
+{"abstract_id": "25130678", "label": "results", "text": "Compared to the placebo group , in the atorvastatin group cholesterol , triglyceride , and Low Density Lipids ( LDL ) significantly decreased , and High Density Lipids ( HDL ) significantly increased over time .", "sentence_id": 7}
+{"abstract_id": "25130678", "label": "results", "text": "HDRS scores and blood lipid values were generally not associated .", "sentence_id": 8}
+{"abstract_id": "25130678", "label": "conclusions", "text": "The pattern of results suggests that adjuvant atorvastatin favorably influences symptoms of depression among patients with severe MDD .", "sentence_id": 9}
+{"abstract_id": "25130678", "label": "conclusions", "text": "Given that after @ weeks of monotherapy and adjuvant atorvastatin patients were still moderately to severely depressed , more powerful treatment algorithms such as augmentation and change of medication are highly recommended .", "sentence_id": 10}
+{"abstract_id": "24721460", "label": "objective", "text": "To compare measurement properties of the P@ pain scale , Western Ontario and McMaster Universities Arthritis Index pain subscale ( WOMAC-pain ) , and Intermittent and Constant Osteoarthritis Pain ( ICOAP ) measure in patients with knee osteoarthritis ( OA ) .", "sentence_id": 0}
+{"abstract_id": "24721460", "label": "methods", "text": "A secondary analysis from a randomized controlled trial included participants ( n = @ ) with knee OA that were consulting with a surgeon regarding knee arthroplasty .", "sentence_id": 1}
+{"abstract_id": "24721460", "label": "methods", "text": "They completed pain measures ( P@ , WOMAC-pain , ICOAP ) and WOMAC-function subscale ( WOMAC-function ) at baseline and @ weeks .", "sentence_id": 2}
+{"abstract_id": "24721460", "label": "methods", "text": "Measurement properties assessed in various subgroups included floor/ceiling effects , test-retest reliability using intraclass correlation coefficients ( ICC@ ,@ ) , internal consistency using Cronbach 's , factorial structure of each pain measure combined with WOMAC-function using principal component analysis , and responsiveness using standardized response mean ( SRM ) .", "sentence_id": 3}
+{"abstract_id": "24721460", "label": "results", "text": "P@ had low floor and ceiling effects ( < @ % ) .", "sentence_id": 4}
+{"abstract_id": "24721460", "label": "results", "text": "P@ test-retest reliability ( ICC@ ,@ = @ ) , internal consistency ( Chronbach 's = @ ) , and responsiveness ( SRM = @ ) were similar to the values for WOMAC-pain and ICOAP .", "sentence_id": 5}
+{"abstract_id": "24721460", "label": "results", "text": "Factorial structure of P@ and ICOAP were separate from WOMAC-function items .", "sentence_id": 6}
+{"abstract_id": "24721460", "label": "results", "text": "WOMAC-pain and WOMAC-function items loaded on similar factors .", "sentence_id": 7}
+{"abstract_id": "24721460", "label": "results", "text": "ICOAP-constant subscale had a large floor effect ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24721460", "label": "conclusions", "text": "P@ should be used to measure pain in patients with knee OA .", "sentence_id": 9}
+{"abstract_id": "24721460", "label": "conclusions", "text": "It had acceptable measurement properties which is comparable to more widely used pain measures .", "sentence_id": 10}
+{"abstract_id": "24721460", "label": "conclusions", "text": "WOMAC-pain shared a factorial structure with WOMAC-function indicating these measures might be capturing the same construct , questioning its validity to measure pain separately from function .", "sentence_id": 11}
+{"abstract_id": "24721460", "label": "conclusions", "text": "ICOAP had acceptable properties .", "sentence_id": 12}
+{"abstract_id": "24721460", "label": "conclusions", "text": "More work should compare pain measures in less severely affected OA populations .", "sentence_id": 13}
+{"abstract_id": "25907157", "label": "background", "text": "Individuals with a history of recurrent depression have a high risk of repeated depressive relapse or recurrence .", "sentence_id": 0}
+{"abstract_id": "25907157", "label": "background", "text": "Maintenance antidepressants for at least @ years is the current recommended treatment , but many individuals are interested in alternatives to medication .", "sentence_id": 1}
+{"abstract_id": "25907157", "label": "background", "text": "Mindfulness-based cognitive therapy ( MBCT ) has been shown to reduce risk of relapse or recurrence compared with usual care , but has not yet been compared with maintenance antidepressant treatment in a definitive trial .", "sentence_id": 2}
+{"abstract_id": "25907157", "label": "background", "text": "We aimed to see whether MBCT with support to taper or discontinue antidepressant treatment ( MBCT-TS ) was superior to maintenance antidepressants for prevention of depressive relapse or recurrence over @ months .", "sentence_id": 3}
+{"abstract_id": "25907157", "label": "methods", "text": "In this single-blind , parallel , group randomised controlled trial ( PREVENT ) , we recruited adult patients with three or more previous major depressive episodes and on a therapeutic dose of maintenance antidepressants , from primary care general practices in urban and rural settings in the UK .", "sentence_id": 4}
+{"abstract_id": "25907157", "label": "methods", "text": "Participants were randomly assigned to either MBCT-TS or maintenance antidepressants ( in a @:@ ratio ) with a computer-generated random number sequence with stratification by centre and symptomatic status .", "sentence_id": 5}
+{"abstract_id": "25907157", "label": "methods", "text": "Participants were aware of treatment allocation and research assessors were masked to treatment allocation .", "sentence_id": 6}
+{"abstract_id": "25907157", "label": "methods", "text": "The primary outcome was time to relapse or recurrence of depression , with patients followed up at five separate intervals during the @-month study period .", "sentence_id": 7}
+{"abstract_id": "25907157", "label": "methods", "text": "The primary analysis was based on the principle of intention to treat .", "sentence_id": 8}
+{"abstract_id": "25907157", "label": "methods", "text": "The trial is registered with Current Controlled Trials , ISRCTN@ .", "sentence_id": 9}
+{"abstract_id": "25907157", "label": "results", "text": "Between March @ , @ , and Oct @ , @ , we assessed @ participants for eligibility and recruited @ patients from @ general practices .", "sentence_id": 10}
+{"abstract_id": "25907157", "label": "results", "text": "@ patients were randomly assigned to MBCT-TS and @ to maintenance antidepressants .", "sentence_id": 11}
+{"abstract_id": "25907157", "label": "results", "text": "The time to relapse or recurrence of depression did not differ between MBCT-TS and maintenance antidepressants over @ months ( hazard ratio @ , @ % CI @-@ ; p = @ ) , nor did the number of serious adverse events .", "sentence_id": 12}
+{"abstract_id": "25907157", "label": "results", "text": "Five adverse events were reported , including two deaths , in each of the MBCT-TS and maintenance antidepressants groups .", "sentence_id": 13}
+{"abstract_id": "25907157", "label": "results", "text": "No adverse events were attributable to the interventions or the trial .", "sentence_id": 14}
+{"abstract_id": "25907157", "label": "conclusions", "text": "We found no evidence that MBCT-TS is superior to maintenance antidepressant treatment for the prevention of depressive relapse in individuals at risk for depressive relapse or recurrence .", "sentence_id": 15}
+{"abstract_id": "25907157", "label": "conclusions", "text": "Both treatments were associated with enduring positive outcomes in terms of relapse or recurrence , residual depressive symptoms , and quality of life .", "sentence_id": 16}
+{"abstract_id": "24862764", "label": "objective", "text": "To compare the effects of exergaming with conventional weight-shift training on balance function in patients with chronic stroke .", "sentence_id": 0}
+{"abstract_id": "24862764", "label": "methods", "text": "Single-blind randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24862764", "label": "methods", "text": "Medical center .", "sentence_id": 2}
+{"abstract_id": "24862764", "label": "methods", "text": "Patients ( N = @ ) with chronic stroke and balance deficits .", "sentence_id": 3}
+{"abstract_id": "24862764", "label": "methods", "text": "Twelve weeks of Wii Fit training or conventional weight-shift training .", "sentence_id": 4}
+{"abstract_id": "24862764", "label": "methods", "text": "Static balance was assessed using posturography .", "sentence_id": 5}
+{"abstract_id": "24862764", "label": "methods", "text": "We recorded the stability index and percentage of weight bearing on the affected leg in @ positions .", "sentence_id": 6}
+{"abstract_id": "24862764", "label": "methods", "text": "We also used the timed Up and Go and forward reach tests for dynamic balance evaluation , Falls Efficacy Scale-International for fear of falling assessment , and Physical Activity Enjoyment Scale for estimating the enjoyment of training .", "sentence_id": 7}
+{"abstract_id": "24862764", "label": "results", "text": "The exergaming group showed more improvement in stability index than the control group in head straight with eyes open while standing on a foam surface , eyes closed while standing on a solid surface with head turned @ to the left , and eyes closed while standing on a solid surface with head turned up positions ( time-group interaction P = @ , @ , and @ , respectively ) ; however , the effects were not maintained .", "sentence_id": 8}
+{"abstract_id": "24862764", "label": "results", "text": "At @-month follow-up , the control group showed more improvement in weight-bearing symmetry in the head straight with eyes open while standing on a solid surface position than the exergaming group ( time-group interaction P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24862764", "label": "results", "text": "Both groups showed improvement in the timed Up and Go test , forward reach test , and fear of falling .", "sentence_id": 10}
+{"abstract_id": "24862764", "label": "results", "text": "The improvement in fear of falling was not maintained .", "sentence_id": 11}
+{"abstract_id": "24862764", "label": "results", "text": "The exergaming group enjoyed training more than the control group ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24862764", "label": "conclusions", "text": "Exergaming is enjoyable and effective for patients with chronic stroke .", "sentence_id": 13}
+{"abstract_id": "25474232", "label": "objective", "text": "The aim of this study was to compare the recurrence rates for primary pterygia after fibrin glue-assisted conjunctival autograft ( CAG ) versus conjunctivolimbal autograft ( CLAG ) transplantation , using a technique of limited conjunctival resection and Tenon extended removal .", "sentence_id": 0}
+{"abstract_id": "25474232", "label": "methods", "text": "In this comparative case series , @ eyes of @ patients with primary nasal pterygium were included .", "sentence_id": 1}
+{"abstract_id": "25474232", "label": "methods", "text": "Patients were randomized into @ groups to undergo fibrin glue-assisted CAG ( group @ , @ eyes ) or fibrin glue-assisted CLAG ( group @ , @ eyes ) following excision of pterygium .", "sentence_id": 2}
+{"abstract_id": "25474232", "label": "methods", "text": "The surgical technique used in all patients involved limited conjunctival resection combined with extensive removal of the Tenon capsule up to the caruncle medially and also @ mm beyond the inferior and superior free edges of the conjunctiva .", "sentence_id": 3}
+{"abstract_id": "25474232", "label": "methods", "text": "The main outcome measure studied was the absence or presence of recurrence .", "sentence_id": 4}
+{"abstract_id": "25474232", "label": "results", "text": "There was @ % recurrence rate in both groups after a mean follow-up of @ weeks ( range , @-@ weeks ) with all eyes completing at least @-year of follow-up .", "sentence_id": 5}
+{"abstract_id": "25474232", "label": "conclusions", "text": "Fibrin glue-assisted CAG and CLAG using the technique of conjunctival resection and Tenon extended removal were equally efficacious in terms of preventing recurrences in patients with primary pterygia in our series .", "sentence_id": 6}
+{"abstract_id": "24421886", "label": "background", "text": "Acellular pertussis vaccines do not control pertussis .", "sentence_id": 0}
+{"abstract_id": "24421886", "label": "background", "text": "A new approach to offer protection to infants is necessary .", "sentence_id": 1}
+{"abstract_id": "24421886", "label": "background", "text": "BPZE@ , a genetically modified Bordetella pertussis strain , was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying @ toxins .", "sentence_id": 2}
+{"abstract_id": "24421886", "label": "methods", "text": "We performed a double-blind , placebo-controlled , dose-escalating study of BPZE@ given intranasally for the first time to human volunteers , the first trial of a live attenuated bacterial vaccine specifically designed for the respiratory tract .", "sentence_id": 3}
+{"abstract_id": "24421886", "label": "methods", "text": "@ subjects per dose group received @ , @ or @ colony-forming units as droplets with half of the dose in each nostril .", "sentence_id": 4}
+{"abstract_id": "24421886", "label": "methods", "text": "@ controls received the diluent .", "sentence_id": 5}
+{"abstract_id": "24421886", "label": "methods", "text": "Local and systemic safety and immune responses were assessed during @ months , and nasopharyngeal colonization with BPZE@ was determined with repeated cultures during the first @ weeks after vaccination .", "sentence_id": 6}
+{"abstract_id": "24421886", "label": "results", "text": "Colonization was seen in one subject in the low dose , one in the medium dose and five in the high dose group .", "sentence_id": 7}
+{"abstract_id": "24421886", "label": "results", "text": "Significant increases in immune responses against pertussis antigens were seen in all colonized subjects .", "sentence_id": 8}
+{"abstract_id": "24421886", "label": "results", "text": "There was one serious adverse event not related to the vaccine .", "sentence_id": 9}
+{"abstract_id": "24421886", "label": "results", "text": "Other adverse events were trivial and occurred with similar frequency in the placebo and vaccine groups .", "sentence_id": 10}
+{"abstract_id": "24421886", "label": "conclusions", "text": "BPZE@ is safe in healthy adults and able to transiently colonize the nasopharynx .", "sentence_id": 11}
+{"abstract_id": "24421886", "label": "conclusions", "text": "It induces immune responses in all colonized individuals .", "sentence_id": 12}
+{"abstract_id": "24421886", "label": "conclusions", "text": "BPZE@ can thus undergo further clinical development , including dose optimization and trials in younger age groups .", "sentence_id": 13}
+{"abstract_id": "25041312", "label": "objective", "text": "This study aimed to evaluate the internal consistency reliability and construct validity of the Fitzpatrick Skin Type Scale during radiation therapy in a cohort of women receiving treatment for breast cancer .", "sentence_id": 0}
+{"abstract_id": "25041312", "label": "methods", "text": "The assessment of the scale was performed as a nested study within a randomised controlled trial of two creams used for radiation therapy skin care for breast cancer patients .", "sentence_id": 1}
+{"abstract_id": "25041312", "label": "methods", "text": "The sample consisted of @ female patients undergoing radiation therapy for breast cancer .", "sentence_id": 2}
+{"abstract_id": "25041312", "label": "methods", "text": "Participants completed a modified version of the Fitzpatrick Skin Type Scale .", "sentence_id": 3}
+{"abstract_id": "25041312", "label": "results", "text": "Internal consistency as measured by Cronbach 's alpha was @ , @ and @ for the Genetic Disposition , Sun Exposure and Tanning Habits subscales respectively .", "sentence_id": 4}
+{"abstract_id": "25041312", "label": "results", "text": "Only the Sun Exposure subscale surpassed the @ cut-off , indicating good internal consistency .", "sentence_id": 5}
+{"abstract_id": "25041312", "label": "results", "text": "Maximum likelihood factor analysis with promax rotation method confirmed the a priori factor structure for the Sun Exposure subscale as well as providing evidence of construct validity for this subscale .", "sentence_id": 6}
+{"abstract_id": "25041312", "label": "results", "text": "Analysis for the other two subscales highlighted issues with internal reliability and construct validity suggesting that not all items on each subscale truly measure the intended trait .", "sentence_id": 7}
+{"abstract_id": "25041312", "label": "conclusions", "text": "The study findings support reliability and validity of the Sun Exposure subscale of the Fitzpatrick Skin Type Scale in a convenience sample of women receiving radiation therapy for cancer .", "sentence_id": 8}
+{"abstract_id": "25041312", "label": "conclusions", "text": "Despite limitations with two of the three subscales , this tool continues to be used in clinical practice .", "sentence_id": 9}
+{"abstract_id": "25611228", "label": "background", "text": "Treatment impact on quality of life ( QoL ) informs treatment management decisions in advanced nonsquamous non-small-cell lung cancer ( NS NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "25611228", "label": "background", "text": "QoL outcomes from the phase III PointBreak trial are reported .", "sentence_id": 1}
+{"abstract_id": "25611228", "label": "methods", "text": "Chemonaive patients ( n = @ ) with stage IIIB/IV nonsquamous non-small-cell lung cancer and Eastern Cooperative Oncology Group performance status @ to @ were randomized ( @:@ ) to pemetrexed-carboplatin-bevacizumab ( pemetrexed arm ) or paclitaxel-carboplatin-bevacizumab ( paclitaxel arm ) .", "sentence_id": 2}
+{"abstract_id": "25611228", "label": "methods", "text": "Patients without progressive disease received maintenance pemetrexed-bevacizumab ( pemetrexed arm ) or bevacizumab ( paclitaxel arm ) .", "sentence_id": 3}
+{"abstract_id": "25611228", "label": "methods", "text": "QoL was assessed using Functional Assessment of Cancer Therapy ( FACT ) - General ( FACT-G ) , FACT-Lung ( FACT-L ) , and FACT/Gynecologic Oncology Group-Neurotoxicity ( FACT-Ntx ) instruments .", "sentence_id": 4}
+{"abstract_id": "25611228", "label": "methods", "text": "Subscale scores , total scores , and trial outcome indices were analyzed using linear mixed-effects models .", "sentence_id": 5}
+{"abstract_id": "25611228", "label": "methods", "text": "Post hoc analyses examined the association between baseline FACT scores and overall survival ( OS ) .", "sentence_id": 6}
+{"abstract_id": "25611228", "label": "results", "text": "Mean score differences in change from baseline significantly favored the pemetrexed arm for the neurotoxicity subscale score , FACT-Ntx total scores , and FACT-Ntx trial outcome index .", "sentence_id": 7}
+{"abstract_id": "25611228", "label": "results", "text": "They occurred at cycle @ ( p < @ ) and persisted through induction cycles @ to @ and six maintenance cycles .", "sentence_id": 8}
+{"abstract_id": "25611228", "label": "results", "text": "Investigator-assessed , qualitative , drug-related differences in grade @ ( @ % versus @ % ) and grade @ ( @ % versus @ % ) sensory neuropathy and grade @/@ fatigue ( @ % versus @ % , p = @ ) were observed between the pemetrexed and paclitaxel arms .", "sentence_id": 9}
+{"abstract_id": "25611228", "label": "results", "text": "Baseline FACT-G , FACT-L , and FACT-Ntx scores were significant prognostic factors for OS ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25611228", "label": "conclusions", "text": "Randomized patients reported similar changes in QoL , except for less change from baseline in neurotoxicity on the pemetrexed arm ; investigators reported greater neurotoxicity on the paclitaxel arm and greater fatigue on the pemetrexed arm .", "sentence_id": 11}
+{"abstract_id": "25611228", "label": "conclusions", "text": "Higher baseline FACT scores were favorable prognostic factors for OS .", "sentence_id": 12}
+{"abstract_id": "24565092", "label": "objective", "text": "Initiation of epidural anesthesia with long-lasting local anesthetics consumes a significant amount of time , which could be problematic in busy obstetric anesthesia suites .", "sentence_id": 0}
+{"abstract_id": "24565092", "label": "objective", "text": "We have hypothesized that a combination of articaine and ropivacaine provides faster onset and even an early recovery of sensory-motor block characteristics .", "sentence_id": 1}
+{"abstract_id": "24565092", "label": "methods", "text": "Sixty term parturients scheduled to have elective cesarean section were randomly allocated into three groups to receive either @ mL @ % articaine ( Group A ) , @ mL @ % articaine + @ mL @ % ropivacaine ( Group AR ) or @ mL @ % ropivacaine ( Group R ) via lumbar epidural catheter .", "sentence_id": 2}
+{"abstract_id": "24565092", "label": "methods", "text": "The onset time of sensory block to T@ , T@ and maximum sensory block level , time to two segments regression from maximum sensory block level , onset time and duration of motor block were all recorded .", "sentence_id": 3}
+{"abstract_id": "24565092", "label": "methods", "text": "Intraoperative and postoperative additional analgesic requirements were also recorded .", "sentence_id": 4}
+{"abstract_id": "24565092", "label": "results", "text": "Demographic data were similar .", "sentence_id": 5}
+{"abstract_id": "24565092", "label": "results", "text": "The onset times of sensorial block to T@ and T@ were significantly shorter in Groups A and AR in comparison with Group R ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24565092", "label": "results", "text": "The onset times of motor block were similar in all groups , but a more intense motor block was observed in Group R ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24565092", "label": "results", "text": "Two segments regression time and motor block durations were significantly shorter in Groups A and AR in comparison with Group R ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24565092", "label": "results", "text": "Intraoperative supplementary analgesic requirements were higher in Group A than in the other two groups ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24565092", "label": "conclusions", "text": "A combination of @ % articaine and @ % ropivacaine for epidural anesthesia in a cesarean section should be preferred over epidural @ % ropivacaine alone .", "sentence_id": 10}
+{"abstract_id": "24638852", "label": "background", "text": "Few clinical studies involving cigarettes have provided a comprehensive picture of smoke exposure , test article characterization , and insights into sensory properties combined .", "sentence_id": 0}
+{"abstract_id": "24638852", "label": "background", "text": "The purpose of these pilot studies was to determine whether cigarettes with different levels of nicotine but similar tar levels would affect sensory experience or smoking behavior so as to significantly alter levels of selected biomarkers of exposure ( BOE ) .", "sentence_id": 1}
+{"abstract_id": "24638852", "label": "methods", "text": "In @ confined , double-blind studies , @ adult smokers switched from Marlboro Gold cigarettes at baseline to either @ of @ lower nicotine cigarettes or @ of @ higher nicotine cigarettes and then to the other cigarette after @ days .", "sentence_id": 2}
+{"abstract_id": "24638852", "label": "methods", "text": "Urinary excretion of exposure biomarkers ( nicotine equivalents -LSB- NE -RSB- , total and free @ - ( methylnitrosamino ) -@ - ( @-pyridyl ) -@ - butanol -LSB- NNAL -RSB- , @-hydroxypyrene , and @-hydroxypropyl mercapturic acid ) as well as carboxyhemoglobin and plasma cotinine were measured at baseline , Day @ , and Day @ .", "sentence_id": 3}
+{"abstract_id": "24638852", "label": "methods", "text": "Daily cigarette consumption was monitored and sensory characteristics were rated for each cigarette .", "sentence_id": 4}
+{"abstract_id": "24638852", "label": "results", "text": "With higher nicotine yield , urine NE , urine total NNAL , and plasma cotinine increased while nonnicotine BOE decreased without changes in cigarette consumption .", "sentence_id": 5}
+{"abstract_id": "24638852", "label": "results", "text": "In contrast , with lower nicotine yield , urine NE , urine total NNAL , and plasma cotinine dropped while nonnicotine BOE and cigarettes per day increased .", "sentence_id": 6}
+{"abstract_id": "24638852", "label": "results", "text": "Higher nicotine cigarettes were rated harsher and stronger than at baseline while lower nicotine cigarettes were less strong .", "sentence_id": 7}
+{"abstract_id": "24638852", "label": "results", "text": "All @ test cigarettes were highly disliked .", "sentence_id": 8}
+{"abstract_id": "24638852", "label": "conclusions", "text": "These studies demonstrate that abrupt increases or decreases in nicotine and the resulting sensory changes impact BOE through changes in intensity or frequency of smoking .", "sentence_id": 9}
+{"abstract_id": "25970861", "label": "objective", "text": "To compare the measurements and growth rates of geographic atrophy ( GA ) secondary to age-related macular degeneration ( AMD ) obtained using different imaging modalities .", "sentence_id": 0}
+{"abstract_id": "25970861", "label": "methods", "text": "Thirty patients with AMD and GA measuring from @ mm to @ mm based on spectral-domain optical coherence tomography ( SD-OCT ) fundus imaging were enrolled .", "sentence_id": 1}
+{"abstract_id": "25970861", "label": "methods", "text": "Imaging was performed at baseline and at follow-up months @ , @ , @ , and @ , including autofluorescence ( AF ) imaging with a fundus camera-based flash system ( TRC-@DX ; Topcon Medical Systems , Oakland , NJ ; AF excitation : @-@ nm ; detection : @-@ nm ) , AF and fluorescein angiography ( FA ) imaging with a confocal scanning laser ophthalmoscopy ( SLO ) system ( Spectralis ; Heidelberg Engineering , Heidelberg , Germany ; AF excitation : @ nm ; detection : > @ nm ) , and SD-OCT en face imaging ( Cirrus ; Carl Zeiss Meditec , Dublin , CA ) .", "sentence_id": 2}
+{"abstract_id": "25970861", "label": "results", "text": "Average baseline square root measurements and enlargement rates of square root areas appeared similar across all modalities ; @ mm was the largest difference between any pair of measurement means .", "sentence_id": 3}
+{"abstract_id": "25970861", "label": "results", "text": "The intraclass correlation coefficients ( ICC ) were essentially equal to @ for all comparisons of area measurements but were lower for growth rates than area measurements .", "sentence_id": 4}
+{"abstract_id": "25970861", "label": "results", "text": "Comparison of @-week average enlargement rates showed no significant difference between the SLO AF image and enhanced SD-OCT en face image ( mean difference : @ mm ; SD : @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25970861", "label": "conclusions", "text": "Agreement among all imaging modalities in measuring the areas of GA at baseline diminished when the growth rates of GA were compared over @ weeks , likely because each imaging technique identifies different anatomic features along the border of GA , which may appear similar but change at different rates .", "sentence_id": 6}
+{"abstract_id": "25130704", "label": "background", "text": "Red blood cell ( RBC ) transfusion is frequently used to treat women with acute anaemia after postpartum haemorrhage .", "sentence_id": 0}
+{"abstract_id": "25130704", "label": "background", "text": "We aimed to assess the economic consequences of red blood cell transfusion compared to non-intervention in these women .", "sentence_id": 1}
+{"abstract_id": "25130704", "label": "methods", "text": "A trial-based cost-effectiveness analysis was performed alongside the Well-Being of Obstetric patients on Minimal Blood transfusions ( WOMB ) trial .", "sentence_id": 2}
+{"abstract_id": "25130704", "label": "methods", "text": "Women with acute anaemia -LSB- Hb @-@g / dl ( @-@mm ) -RSB- after postpartum haemorrhage , without severe anaemic symptoms , were randomly allocated to RBC transfusion or non-intervention .", "sentence_id": 3}
+{"abstract_id": "25130704", "label": "methods", "text": "Primary outcome of the trial was physical fatigue ( Multidimensional Fatigue Inventory , scale @-@ ; @ represents maximal fatigue ) .", "sentence_id": 4}
+{"abstract_id": "25130704", "label": "methods", "text": "Total costs per arm were calculated using a hospital perspective with a @weeks time horizon .", "sentence_id": 5}
+{"abstract_id": "25130704", "label": "results", "text": "Per woman , mean costs in the RBC transfusion arm ( n = @ ) were @ compared to @ in the non-intervention arm ( n = @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25130704", "label": "results", "text": "The @ % difference in costs between study arms predominantly originated from costs of RBC units , as costs of RBC units were six times higher in the RBC transfusion arm .", "sentence_id": 7}
+{"abstract_id": "25130704", "label": "results", "text": "RBC transfusion led to a small improvement in physical fatigue of @ points per day ; thus , the costs to improve the physical fatigue score with one point would be @ .", "sentence_id": 8}
+{"abstract_id": "25130704", "label": "conclusions", "text": "In women with acute anaemia after postpartum haemorrhage ( PPH ) , RBC transfusion is on average @ more expensive per woman than non-intervention , with only a small gain in HRQoL after RBC transfusion .", "sentence_id": 9}
+{"abstract_id": "25130704", "label": "conclusions", "text": "Taking both clinical and economic consequences into account , implementation of a non-intervention policy seems justified .", "sentence_id": 10}
+{"abstract_id": "25077896", "label": "background", "text": "Regular endotracheal tube cuff monitoring may prevent silent aspiration .", "sentence_id": 0}
+{"abstract_id": "25077896", "label": "objective", "text": "We hypothesised that active management of the cuff of the tracheal tube during deep hypothermic cardiac arrest would reduce silent subglottic aspiration .", "sentence_id": 1}
+{"abstract_id": "25077896", "label": "objective", "text": "We also determined to study its effect on postoperative mechanical ventilation and the incidence of postoperative positive tracheal cultures .", "sentence_id": 2}
+{"abstract_id": "25077896", "label": "methods", "text": "A randomised clinical trial .", "sentence_id": 3}
+{"abstract_id": "25077896", "label": "methods", "text": "The study was conducted in a University Teaching Hospital from September @ to November @ .", "sentence_id": 4}
+{"abstract_id": "25077896", "label": "methods", "text": "Twenty-four patients undergoing elective pulmonary endarterectomy were included in the study .", "sentence_id": 5}
+{"abstract_id": "25077896", "label": "methods", "text": "After induction of general anaesthesia and tracheal intubation , the cuff of the tracheal tube was inflated to @cmH@O .", "sentence_id": 6}
+{"abstract_id": "25077896", "label": "methods", "text": "Following this , @ml of methylene blue dye diluted in @ml of physiological saline was injected into the hypopharynx .", "sentence_id": 7}
+{"abstract_id": "25077896", "label": "methods", "text": "Patients were randomly assigned to active cuff management during cooling and warming ( where cuff pressure was monitored and the cuff was reinflated if it dropped below @cmH@O , or deflated if pressure exceeded @cmH@O ) or passive monitoring ( where cuff pressure was monitored but volume was not altered ) .", "sentence_id": 8}
+{"abstract_id": "25077896", "label": "methods", "text": "Before weaning from cardiopulmonary bypass , fibreoptic bronchoscopy was performed .", "sentence_id": 9}
+{"abstract_id": "25077896", "label": "methods", "text": "Silent aspiration was then diagnosed if blue dye was seen in the trachea below the cuff of the tube .", "sentence_id": 10}
+{"abstract_id": "25077896", "label": "methods", "text": "The primary aim of this study was to determine the incidence of silent aspiration .", "sentence_id": 11}
+{"abstract_id": "25077896", "label": "methods", "text": "Secondary outcomes included duration of postoperative mechanical ventilation of the lungs and incidence of positive culture of tracheal aspirate .", "sentence_id": 12}
+{"abstract_id": "25077896", "label": "results", "text": "Active cuff management patients were younger than controls ( @ vs. @ years , P = @ ) , but otherwise the two groups were similar .", "sentence_id": 13}
+{"abstract_id": "25077896", "label": "results", "text": "The primary endpoint was reached because we showed that silent aspiration was significantly less frequent in the study group ( @/@ vs. @/@ patients , P = @ ) .", "sentence_id": 14}
+{"abstract_id": "25077896", "label": "results", "text": "Significantly lower intracuff pressures were measured in the control group patients at several timepoints during cooling , just before hypothermic arrest and at all timepoints during rewarming .", "sentence_id": 15}
+{"abstract_id": "25077896", "label": "conclusions", "text": "We recommend that the cuff of the tracheal tube should be checked regularly during surgery under deep hypothermia , and the cuff pressure adjusted as required .", "sentence_id": 16}
+{"abstract_id": "24742019", "label": "background", "text": "Cetuximab is a chimeric monoclonal antibody against the epidermal growth factor receptor ( EGFR ) .", "sentence_id": 0}
+{"abstract_id": "24742019", "label": "background", "text": "Skin reactions are the most common side effects of cetuximab .", "sentence_id": 1}
+{"abstract_id": "24742019", "label": "background", "text": "Rhagades of the tips of the fingers and toes , the heels and especially the interphalangeal joints are one of the most frightening and painful dermatological side effects that may develop from EGFR-inhibitor therapy .", "sentence_id": 2}
+{"abstract_id": "24742019", "label": "background", "text": "Rhagades are characterized by pain , severe tenderness and poor healing response .", "sentence_id": 3}
+{"abstract_id": "24742019", "label": "background", "text": "They are challenging to treat .", "sentence_id": 4}
+{"abstract_id": "24742019", "label": "background", "text": "Thus , rhagades often poses the most significant threat to the quality of life ( QoL ) for these patients .", "sentence_id": 5}
+{"abstract_id": "24742019", "label": "background", "text": "Ethyl-@-cyanoacrylate ( ECA ) , an ethyl ester of the @-cyano-@-propenoic acid , is often used as adhesive in a variety of different work settings in industry , i.e. as a component in nail-care products such as nail glue .", "sentence_id": 6}
+{"abstract_id": "24742019", "label": "background", "text": "In addition , ECA is used for various medical indications , such as for liquid bandages and for suture-less surgery .", "sentence_id": 7}
+{"abstract_id": "24742019", "label": "background", "text": "Wound healing can be accelerated with ECA .", "sentence_id": 8}
+{"abstract_id": "24742019", "label": "background", "text": "The purpose of the SUPPORT trial is to investigate the efficacy of ECA for the treatment of cetuximab-induced rhagades and to assess the clinical usefulness of the SUPO score , a new classification system for rhagades induced by EGFR-inhibitor therapy .", "sentence_id": 9}
+{"abstract_id": "24742019", "label": "methods", "text": "The SUPPORT trial is an open-label , prospective , randomized , national multicenter intervention study to evaluate the effectiveness of ECA versus the standard treatment of each institution on the pain intensity and QoL in patients with locally advanced head and neck cancer suffering from painful cetuximab-induced rhagades during radioimmunotherapy .", "sentence_id": 10}
+{"abstract_id": "24742019", "label": "methods", "text": "Primary endpoint is the assessment of the pain intensity @ hours after application of ECA or the standard treatment quantified by the visual analogue scale ( VAS ) .", "sentence_id": 11}
+{"abstract_id": "24742019", "label": "methods", "text": "Secondary endpoints are the evaluation of QoL assessed by the EORTC-QoL-C@ questionnaire and the Dermatological Life Quality Index ( DLQI ) .", "sentence_id": 12}
+{"abstract_id": "24742019", "label": "conclusions", "text": "During treatment with EGFR inhibitors it is necessary to recognize and manage side effects promptly to assure better patient QoL .", "sentence_id": 13}
+{"abstract_id": "24742019", "label": "conclusions", "text": "The SUPPORT trial is the first randomized clinical trial evaluating a new treatment option for painful cetuximab-induced rhagades .", "sentence_id": 14}
+{"abstract_id": "24742019", "label": "conclusions", "text": "Furthermore , the new SUPO score will be prospectively assessed in terms of clinical usefulness for classification of EGFR inhibitor-induced rhagades .", "sentence_id": 15}
+{"abstract_id": "24655119", "label": "background", "text": "The aim of this study was to characterize cardiac reactivity measures , heart rate ( HR ) , and heart rate variability ( HRV ) , following acute intravenous ( IV ) alcohol administration and their association with subjective responses in social drinkers .", "sentence_id": 0}
+{"abstract_id": "24655119", "label": "methods", "text": "Twenty-four subjects ( @ females ) received IV alcohol infusions to attain and clamp the breath alcohol concentration ( BrAC ) at @ mg % or placebo in separate sessions .", "sentence_id": 1}
+{"abstract_id": "24655119", "label": "methods", "text": "Serial @-minute cardiac recordings at baseline and during the infusion were analyzed to obtain frequency and time domain cardiac measures .", "sentence_id": 2}
+{"abstract_id": "24655119", "label": "methods", "text": "Self-reported subjective perceptions were also obtained at the same time points .", "sentence_id": 3}
+{"abstract_id": "24655119", "label": "results", "text": "HR showed significant decreases from baseline , while the HRV measure pNN@ showed steady increases during the ascending phase of alcohol infusion .", "sentence_id": 4}
+{"abstract_id": "24655119", "label": "results", "text": "HR was inversely correlated with pNN@ across time and treatment .", "sentence_id": 5}
+{"abstract_id": "24655119", "label": "results", "text": "There was a significant association of HR with subjective feelings of high , intoxication , feeling drug effects , and liking drug effects across time during the ascending phase .", "sentence_id": 6}
+{"abstract_id": "24655119", "label": "conclusions", "text": "Acute IV alcohol resulted in decreases in HR and increases in HRV consistent with autonomic parasympathetic activation .", "sentence_id": 7}
+{"abstract_id": "24655119", "label": "conclusions", "text": "The association of these changes with subjective responses suggests that cardiac reactivity may serve as a physiological marker of subjective alcohol effects .", "sentence_id": 8}
+{"abstract_id": "24655119", "label": "conclusions", "text": "This study broadens the understanding of acute cardiovascular effects of alcohol and clinically significant cardiac conditions such as arrhythmia and cardiomyopathy associated with chronic alcohol drinking .", "sentence_id": 9}
+{"abstract_id": "24911577", "label": "objective", "text": "A @-h phase advance model of insomnia was used to evaluate the efficacy of lorediplon , a new non-benzodiazepine hypnotic .", "sentence_id": 0}
+{"abstract_id": "24911577", "label": "methods", "text": "Thirty-five male , healthy subjects were included in a five-way randomized cross-over study .", "sentence_id": 1}
+{"abstract_id": "24911577", "label": "methods", "text": "During each of the periods , sleep was recorded , and residual effects were measured .", "sentence_id": 2}
+{"abstract_id": "24911577", "label": "methods", "text": "All subjects received lorediplon @ , @ , and @ mg , placebo , and zolpidem @ mg ( i.e. , active control ) .", "sentence_id": 3}
+{"abstract_id": "24911577", "label": "results", "text": "Polysomnographic evaluation revealed that lorediplon ( @ and @ mg ) significantly decreased wake after sleep onset ( WASO ) and increased total sleep time .", "sentence_id": 4}
+{"abstract_id": "24911577", "label": "results", "text": "Analysis by quarters of the night showed a progressive increasing effectiveness of lorediplon @ mg across the first three quarters .", "sentence_id": 5}
+{"abstract_id": "24911577", "label": "results", "text": "Lorediplon increased non-rapid eye movement slow wave sleep and stage N@ sleep in the second and third quarters .", "sentence_id": 6}
+{"abstract_id": "24911577", "label": "results", "text": "The magnitude of these effects was dose related , with minimal effects seen with @ mg .", "sentence_id": 7}
+{"abstract_id": "24911577", "label": "results", "text": "No residual effects were observed @ h post dose .", "sentence_id": 8}
+{"abstract_id": "24911577", "label": "conclusions", "text": "Lorediplon demonstrated a dose-dependent improvement in sleep , whereas zolpidem showed a more sustained WASO effect .", "sentence_id": 9}
+{"abstract_id": "24911577", "label": "conclusions", "text": "No next-day hangover effects were observed .", "sentence_id": 10}
+{"abstract_id": "24911577", "label": "conclusions", "text": "These sleep effects are also consistent with the pharmacokinetic profile of lorediplon .", "sentence_id": 11}
+{"abstract_id": "24911577", "label": "conclusions", "text": "These results warrant clinical trials in patients with insomnia .", "sentence_id": 12}
+{"abstract_id": "24290290", "label": "background", "text": "Whether adiposity indicators other than body mass index ( BMI ) should be used in studies of childhood asthma is largely unknown .", "sentence_id": 0}
+{"abstract_id": "24290290", "label": "background", "text": "The role of atopy in `` obese asthma '' is also unclear .", "sentence_id": 1}
+{"abstract_id": "24290290", "label": "objective", "text": "To examine the relationship among adiposity indicators , asthma , and atopy in Puerto Rican children , and to assess whether atopy mediates the obesity-asthma association .", "sentence_id": 2}
+{"abstract_id": "24290290", "label": "methods", "text": "In a study of Puerto Rican children with ( n = @ ) and without ( n = @ ) asthma , we measured BMI , percent of body fat , waist circumference , and waist-to-hip ratio .", "sentence_id": 3}
+{"abstract_id": "24290290", "label": "methods", "text": "The outcomes studied included asthma , lung function , measures of atopy , and , among cases , indicators of asthma severity or control .", "sentence_id": 4}
+{"abstract_id": "24290290", "label": "methods", "text": "We performed mediation analysis to assess the contribution of atopy to the relationship between adiposity and asthma .", "sentence_id": 5}
+{"abstract_id": "24290290", "label": "results", "text": "BMI , percent of body fat , and waist circumference were associated with increased odds of asthma .", "sentence_id": 6}
+{"abstract_id": "24290290", "label": "results", "text": "Among cases , all @ measures were generally associated with lung function , asthma severity/control , and atopy ; however , there were differences depending on the adiposity indicator analyzed .", "sentence_id": 7}
+{"abstract_id": "24290290", "label": "results", "text": "Atopy considerably mediated the adiposity-asthma association in this population : allergic rhinitis accounted for @ % to @ % of the association with asthma , and sensitization to cockroach mediated @ % to @ % of the association with forced vital capacity and @ % to @ % of the association with emergency department visits for asthma .", "sentence_id": 8}
+{"abstract_id": "24290290", "label": "conclusions", "text": "Adiposity indicators are associated with asthma , asthma severity/control , and atopy in Puerto Rican children .", "sentence_id": 9}
+{"abstract_id": "24290290", "label": "conclusions", "text": "Atopy significantly mediates the effect of adiposity on asthma outcomes .", "sentence_id": 10}
+{"abstract_id": "24290290", "label": "conclusions", "text": "Longitudinal studies are needed to further investigate the causal role , if any , of adiposity distribution and atopy on `` obese asthma '' in childhood .", "sentence_id": 11}
+{"abstract_id": "24702835", "label": "background", "text": "Preconception-initiated low-dose aspirin might positively affect pregnancy outcomes , but this possibility has not been adequately assessed .", "sentence_id": 0}
+{"abstract_id": "24702835", "label": "background", "text": "Our aim was to investigate whether low-dose aspirin improved livebirth rates in women with one to two previous pregnancy losses .", "sentence_id": 1}
+{"abstract_id": "24702835", "label": "methods", "text": "In this multicentre , block-randomised , double-blind , placebo-controlled trial , women aged @-@ years who were attempting to become pregnant were recruited from four medical centres in the USA .", "sentence_id": 2}
+{"abstract_id": "24702835", "label": "methods", "text": "Participants were stratified by eligibility criteria -- the original stratum was restricted to women with one loss at less than @ weeks ' gestation during the previous year , whereas the expanded stratum included women with one to two previous losses , with no restrictions on gestational age or time of loss .", "sentence_id": 3}
+{"abstract_id": "24702835", "label": "methods", "text": "Women were block-randomised by centre and eligibility stratum in a @:@ ratio .", "sentence_id": 4}
+{"abstract_id": "24702835", "label": "methods", "text": "Preconception-initiated daily low-dose aspirin ( @ mg per day ) plus folic acid was compared with placebo plus folic acid for up to six menstrual cycles ; for women who conceived , study treatment continued until @ weeks ' gestation .", "sentence_id": 5}
+{"abstract_id": "24702835", "label": "methods", "text": "Participants , trial staff , and investigators were masked to the assigned treatment .", "sentence_id": 6}
+{"abstract_id": "24702835", "label": "methods", "text": "The primary outcome was livebirth rate , which was analysed by intention to treat .", "sentence_id": 7}
+{"abstract_id": "24702835", "label": "methods", "text": "The trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24702835", "label": "results", "text": "Overall , @ women were recruited and randomly assigned between June @ , @ , and July @ , @ , @ of whom completed the trial and were included in the analysis ( @ in the low-dose aspirin group and @ in the placebo group ) .", "sentence_id": 9}
+{"abstract_id": "24702835", "label": "results", "text": "@ ( @ % ) women in the low-dose aspirin group had livebirths , compared with @ ( @ % ) in the placebo group ( p = @ ; absolute difference in livebirth rate @ % -LSB- @ % CI -@ to @ -RSB- ) .", "sentence_id": 10}
+{"abstract_id": "24702835", "label": "results", "text": "Pregnancy loss occurred in @ ( @ % ) women in the low-dose aspirin group , compared with @ ( @ % ) women in the placebo group ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24702835", "label": "results", "text": "In the original stratum , @ ( @ % ) of @ women in the low-dose aspirin group had livebirths , compared with @ ( @ % ) of @ in the placebo group ( p = @ ; absolute difference in livebirth rate @ % -LSB- @ to @ -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "24702835", "label": "results", "text": "In the expanded stratum , @ ( @ % ) of @ women in the low-dose aspirin group and @ ( @ % ) of @ in the placebo group had livebirths ( p = @ ; absolute difference in livebirth rate @ % -LSB- -@ to @ -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "24702835", "label": "results", "text": "Major adverse events were similar between treatment groups .", "sentence_id": 14}
+{"abstract_id": "24702835", "label": "results", "text": "Low-dose aspirin was associated with increased vaginal bleeding , but this adverse event was not associated with pregnancy loss .", "sentence_id": 15}
+{"abstract_id": "24702835", "label": "conclusions", "text": "Preconception-initiated low-dose aspirin was not significantly associated with livebirth or pregnancy loss in women with one to two previous losses .", "sentence_id": 16}
+{"abstract_id": "24702835", "label": "conclusions", "text": "However , higher livebirth rates were seen in women with a single documented loss at less than @ weeks ' gestation during the previous year .", "sentence_id": 17}
+{"abstract_id": "24702835", "label": "conclusions", "text": "Low-dose aspirin is not recommended for the prevention of pregnancy loss .", "sentence_id": 18}
+{"abstract_id": "25735045", "label": "objective", "text": "To evaluate intereye corneal asymmetry in Pentacam ( Oculus Optikgerte GmbH , Wetzlar , Germany ) indices as a diagnostic method between normal patients and patients with keratoconus .", "sentence_id": 0}
+{"abstract_id": "25735045", "label": "methods", "text": "A retrospective , observational case series of @ healthy , @ indeterminate , and @ patients with keratoconus classified by Pentacam ectasia detection indices , randomized to analysis and validation datasets .", "sentence_id": 1}
+{"abstract_id": "25735045", "label": "methods", "text": "Intereye asymmetry in @ Scheimpflug tomography corneal descriptors was calculated and compared to develop diagnostic models .", "sentence_id": 2}
+{"abstract_id": "25735045", "label": "results", "text": "Intereye asymmetry was not correlated with anisometropia in healthy controls but was correlated with the ectasia grade of the worse eye in patients with keratoconus .", "sentence_id": 3}
+{"abstract_id": "25735045", "label": "results", "text": "Patients with keratoconus had significantly greater intereye asymmetry in all descriptors except for relational thickness indices .", "sentence_id": 4}
+{"abstract_id": "25735045", "label": "results", "text": "Intereye asymmetry in front elevation at the thinnest corneal location afforded the single highest diagnostic performance ( @ % sensitivity and @ % specificity ) , whereas the best multivariate model combining intereye asymmetry in anterior and posterior keratometry , corneal thickness , and front and back elevation at the thinnest point provided @ % sensitivity and @ % specificity .", "sentence_id": 5}
+{"abstract_id": "25735045", "label": "results", "text": "Multivariate models upheld their performance in the validation dataset .", "sentence_id": 6}
+{"abstract_id": "25735045", "label": "results", "text": "Most ( more than @ % ) indeterminate patients , according to conventional Pentacam analysis , showed within-normal-range corneal asymmetry .", "sentence_id": 7}
+{"abstract_id": "25735045", "label": "conclusions", "text": "Healthy corneas are markedly symmetric irrespective of anisometropia , but corneal asymmetry analysis does not provide sufficient sensitivity to be used alone for detecting keratoconus .", "sentence_id": 8}
+{"abstract_id": "25735045", "label": "conclusions", "text": "However , its remarkable specificity suggests that it could be used combined with conventional single cornea Pentacam analysis to reduce the false-positive rate or in dubious cases .", "sentence_id": 9}
+{"abstract_id": "25847555", "label": "objective", "text": "To determine effects of Argentine tango on motor and non-motor manifestations of Parkinson 's disease .", "sentence_id": 0}
+{"abstract_id": "25847555", "label": "methods", "text": "Randomized control trial .", "sentence_id": 1}
+{"abstract_id": "25847555", "label": "methods", "text": "Forty patients with idiopathic Parkinson 's disease .", "sentence_id": 2}
+{"abstract_id": "25847555", "label": "methods", "text": "Movement disorder clinic and dance studio .", "sentence_id": 3}
+{"abstract_id": "25847555", "label": "methods", "text": "Two randomized groups : group ( N = @ ) with @ partnered tango classes , and control self-directed exercise group ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "25847555", "label": "methods", "text": "The primary outcome was overall motor severity .", "sentence_id": 5}
+{"abstract_id": "25847555", "label": "methods", "text": "Secondary outcomes included other motor measures , balance , cognition , fatigue , apathy , depression and quality of life .", "sentence_id": 6}
+{"abstract_id": "25847555", "label": "results", "text": "On the primary intention-to-treat analysis there was no difference in motor severity between groups MDS-UPDRS-@ ( @ vs@-point reduction , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25847555", "label": "results", "text": "Patient-rated clinical global impression of change did not differ ( p = @ ) , however examiner rating improved in favor of tango ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25847555", "label": "results", "text": "Mini-BESTest improved in the tango group compared to controls ( @ vs. -@ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25847555", "label": "results", "text": "Among individual items , tango improved in both simple TUG time ( -@ s vs. @ , p = @ ) and TUG Dual Task score ( @ vs. -@ , p = @ ) , with borderline improvement in walk with pivot turns ( @ vs. -@ , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25847555", "label": "results", "text": "MoCa ( @ vs. -@ , p = @ ) and FSS ( -@ vs. @ , p = @ ) showed a non-significant trend toward improvement in the tango group .", "sentence_id": 11}
+{"abstract_id": "25847555", "label": "results", "text": "Tango participants found the activity more enjoyable ( p < @ ) and felt more `` overall '' treatment satisfaction ( p < @ ) .", "sentence_id": 12}
+{"abstract_id": "25847555", "label": "results", "text": "We found no significant differences in other outcomes or adverse events .", "sentence_id": 13}
+{"abstract_id": "25847555", "label": "conclusions", "text": "Argentine tango can improve balance , and functional mobility , and may have modest benefits upon cognition and fatigue in Parkinson 's disease .", "sentence_id": 14}
+{"abstract_id": "25847555", "label": "conclusions", "text": "These findings must be confirmed in longer-term trials explicitly powered for cognition and fatigue .", "sentence_id": 15}
+{"abstract_id": "25390870", "label": "objective", "text": "The aim of this preliminary clinical report was to evaluate and compare the clinical outcomes of immediate and early loaded mini-implants ( MIs ) supporting mandibular overdentures .", "sentence_id": 0}
+{"abstract_id": "25390870", "label": "methods", "text": "Thirty-six completely edentulous patients ( @ men and @ women ) complaining of insufficient retention of their mandibular dentures were randomly assigned to two groups .", "sentence_id": 1}
+{"abstract_id": "25390870", "label": "methods", "text": "Each patient received four MIs in the interforaminal area of the mandible using the nonsubmerged flapless surgical approach .", "sentence_id": 2}
+{"abstract_id": "25390870", "label": "methods", "text": "In group @ ( G@ ) , MIs were loaded with mandibular overdentures using the immediate loading protocol , while in group @ ( G@ ) , MIs were loaded with overdentures using the early loading protocol .", "sentence_id": 3}
+{"abstract_id": "25390870", "label": "methods", "text": "The cumulative survival rate was calculated using Kaplan-Meier analysis .", "sentence_id": 4}
+{"abstract_id": "25390870", "label": "methods", "text": "Peri-implant health indices ( Plaque Index/Bleeding Index ) , probing depths , and marginal bone levels were recorded for both groups after MI insertions and @ , @ , @ , and @ months thereafter .", "sentence_id": 5}
+{"abstract_id": "25390870", "label": "results", "text": "The cumulative implant survival rates were @ % and @ % for G@ and G@ , respectively .", "sentence_id": 6}
+{"abstract_id": "25390870", "label": "results", "text": "G@ recorded significantly higher Plaque Index , Bleeding Index , and probing depths than G@ after @ months , while other observation times demonstrated no significant difference between groups .", "sentence_id": 7}
+{"abstract_id": "25390870", "label": "results", "text": "Most of the recorded marginal bone loss occurred in the first year , and no significant bone loss was noted in subsequent years .", "sentence_id": 8}
+{"abstract_id": "25390870", "label": "results", "text": "After @ months , marginal bone loss was significantly higher in G@ compared to G@ , but no significant differences between groups were noted thereafter .", "sentence_id": 9}
+{"abstract_id": "25390870", "label": "conclusions", "text": "Within the limitations of this study 's research design and duration of follow-up outcome analyses , immediate and early loading protocols showed good clinical results with favorable peri-implant tissue response @ years after implant insertion .", "sentence_id": 10}
+{"abstract_id": "25390870", "label": "conclusions", "text": "Early loading of MIs supporting a mandibular overdenture appears to be preferable to immediate loading .", "sentence_id": 11}
+{"abstract_id": "24627290", "label": "objective", "text": "Gemigliptin is a novel dipeptidyl peptidase-@ ( DPP-@ ) inhibitor used in the treatment of type @ diabetes mellitus .", "sentence_id": 0}
+{"abstract_id": "24627290", "label": "objective", "text": "This study evaluated possible pharmacodynamic and pharmacokinetic interactions between gemigliptin and metformin and investigated their tolerability .", "sentence_id": 1}
+{"abstract_id": "24627290", "label": "methods", "text": "A randomized , open-label , multiple-dose , three-treatment , three-period , three-sequence crossover study was conducted in healthy male subjects .", "sentence_id": 2}
+{"abstract_id": "24627290", "label": "methods", "text": "Twenty-seven subjects received gemigliptin ( @mg once daily ) , metformin ( @,@ mg twice a day ) , or both drugs for @days per dosing period .", "sentence_id": 3}
+{"abstract_id": "24627290", "label": "methods", "text": "Blood samples were drawn over @h on the seventh day of each period for pharmacokinetic and pharmacodynamic evaluations , including plasma DPP-@ activity and total/active glucagon-like peptide-@ ( GLP-@ ) levels .", "sentence_id": 4}
+{"abstract_id": "24627290", "label": "methods", "text": "Meal tolerance tests were conducted for pharmacodynamic assessment on the eighth day .", "sentence_id": 5}
+{"abstract_id": "24627290", "label": "methods", "text": "Safety and tolerability were evaluated using adverse events , vital signs , ECGs , and clinical laboratory tests .", "sentence_id": 6}
+{"abstract_id": "24627290", "label": "results", "text": "Coadministration of gemigliptin and metformin had no significant effect on the pharmacokinetics of gemigliptin or metformin .", "sentence_id": 7}
+{"abstract_id": "24627290", "label": "results", "text": "The inhibition of DPP-@ by gemigliptin was not affected by coadministration with metformin .", "sentence_id": 8}
+{"abstract_id": "24627290", "label": "results", "text": "Co-therapy of gemigliptin and metformin showed additional effects by increasing plasma active GLP-@ concentrations and lowering serum glucose levels .", "sentence_id": 9}
+{"abstract_id": "24627290", "label": "results", "text": "The plasma glucagon level was lower in co-therapy than with metformin monotherapy .", "sentence_id": 10}
+{"abstract_id": "24627290", "label": "results", "text": "The coadministration of gemigliptin and metformin was well-tolerated without serious adverse events .", "sentence_id": 11}
+{"abstract_id": "24627290", "label": "conclusions", "text": "Coadministration of gemigliptin and metformin showed beneficial anti-diabetic effects without pharmacokinetic drug-drug interactions .", "sentence_id": 12}
+{"abstract_id": "24898680", "label": "background", "text": "The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exercise .", "sentence_id": 0}
+{"abstract_id": "24898680", "label": "methods", "text": "Using a @ x @ factorial design with continuous effect endpoint ( Maximal Oxygen Uptake ( VO@peak ) ) , @ patients with non-small cell lung cancer ( NSCLC ) stage I-IIIa referred for surgical resection will be randomly assigned to one of four groups : ( @ ) preoperative and early postoperative rehabilitation ( starting two weeks after surgery ) ; ( @ ) preoperative and late postoperative rehabilitation ( starting six weeks after surgery ) ; ( @ ) early postoperative rehabilitation alone ; ( @ ) today 's standard care which is postoperative rehabilitation initiated six weeks after surgery .", "sentence_id": 1}
+{"abstract_id": "24898680", "label": "methods", "text": "The preoperative rehabilitation program consists of an individually designed , @-minute home-based exercise program performed daily .", "sentence_id": 2}
+{"abstract_id": "24898680", "label": "methods", "text": "The postoperative rehabilitation program consists of a supervised group exercise program comprising cardiovascular and resistance training two-hour weekly for @ weeks combined with individual counseling .", "sentence_id": 3}
+{"abstract_id": "24898680", "label": "methods", "text": "The primary study endpoint is VO@peak and secondary endpoints include : Six-minute walk distance ( @MWD ) , one-repetition-maximum ( @RM ) , pulmonary function , patient-reported outcomes ( PROs ) on health-related quality of life ( HRQoL ) , symptoms and side effects of the cancer disease and the treatment of the disease , anxiety , depression , wellbeing , lifestyle , hospitalization time , sick leave , work status , postoperative complications ( up to @ days after surgery ) and survival .", "sentence_id": 4}
+{"abstract_id": "24898680", "label": "methods", "text": "Endpoints will be assessed at baseline , the day before surgery , pre-intervention , post-intervention , six months after surgery and one year after surgery .", "sentence_id": 5}
+{"abstract_id": "24898680", "label": "conclusions", "text": "The results of the PROLUCA study may potentially contribute to the identification of the optimal perioperative rehabilitation for operable lung cancer patients focusing on exercise initiated immediately after diagnosis and rehabilitation shortly after surgery .", "sentence_id": 6}
+{"abstract_id": "25736132", "label": "objective", "text": "To investigate the safety and feasibility of domestically made endoscopic stapling instrument in laparoscopic assisted rectal cancer resection ( Dixon ) .", "sentence_id": 0}
+{"abstract_id": "25736132", "label": "methods", "text": "Sixty-four patients with rectal cancer were randomly divided into the research group ( @ cases ) to receive laparoscopic assisted rectal cancer resection using ENDO RLC general endoscopic linear cutter and single-use loading unit and circular staplers with staples ( from REACH medical equipment co.LTD ) and the control group ( @ cases ) to receive surgery with the corresponding products widely used ( fom Johnson and Johnson Medical Euipment C.Ltd ) .", "sentence_id": 1}
+{"abstract_id": "25736132", "label": "methods", "text": "The clinical data of the two groups were compared .", "sentence_id": 2}
+{"abstract_id": "25736132", "label": "results", "text": "Satisfactory therapeutic effects were obtained in all the cases .", "sentence_id": 3}
+{"abstract_id": "25736132", "label": "results", "text": "The two groups showed no significant differences in the operative time , intraoperative anastomosis success rate , or postoperative complications ( anastomotic bleeding , leakage , or stricture ) between the two groups ( P > @ ) , but the average cost of endoscopic stapling instrument was significantly lower in the research group ( @ @ vs @ @ RMB Yuan , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25736132", "label": "conclusions", "text": "The domestic endoscopic stapling instrument is safe , effective and less costly for laparoscopic assisted rectal cancer resection .", "sentence_id": 5}
+{"abstract_id": "25647781", "label": "objective", "text": "Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors @-@ .", "sentence_id": 0}
+{"abstract_id": "25647781", "label": "objective", "text": "This analysis compared efficacy and safety of axitinib plus gemcitabine in patients with advanced pancreatic cancer from Japan , North America and the European Union , enrolled in a randomized Phase III study .", "sentence_id": 1}
+{"abstract_id": "25647781", "label": "methods", "text": "Patients ( n = @ ) , stratified by disease extent , were randomly assigned ( @:@ ) to receive axitinib/gemcitabine or placebo/gemcitabine .", "sentence_id": 2}
+{"abstract_id": "25647781", "label": "methods", "text": "Axitinib was administered at a starting dose of @ mg orally twice daily and gemcitabine at @ mg/m ( @ ) once weekly for @ weeks in @ week cycles .", "sentence_id": 3}
+{"abstract_id": "25647781", "label": "methods", "text": "Primary endpoint was overall survival .", "sentence_id": 4}
+{"abstract_id": "25647781", "label": "results", "text": "Among Japanese patients , median overall survival was not estimable ( @ % confidence interval , @ months-not estimable ) with axitinib/gemcitabine ( n = @ ) and @ months ( @ % confidence interval , @-@ @ ) with placebo/gemcitabine ( n = @ ) ( hazard ratio @ -LSB- @ % confidence interval , @-@ @ -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "25647781", "label": "results", "text": "Median survival follow-up ( range ) was @ months ( @-@ @ ) with axitinib/gemcitabine vs. @ months ( @-@ @ ) with placebo/gemcitabine .", "sentence_id": 6}
+{"abstract_id": "25647781", "label": "results", "text": "Similarly , no difference was detected in overall survival between axitinib/gemcitabine and placebo/gemcitabine in patients from North America or the European Union .", "sentence_id": 7}
+{"abstract_id": "25647781", "label": "results", "text": "Common adverse events with axitinib/gemcitabine in Japanese patients were fatigue , anorexia , dysphonia , nausea and decreased platelet count .", "sentence_id": 8}
+{"abstract_id": "25647781", "label": "results", "text": "Axitinib safety profile was generally similar in patients from the three regions , although there were differences in incidence of some adverse events .", "sentence_id": 9}
+{"abstract_id": "25647781", "label": "results", "text": "An exploratory analysis did not show any correlation between axitinib/gemcitabine-related hypertension and overall survival .", "sentence_id": 10}
+{"abstract_id": "25647781", "label": "conclusions", "text": "Axitinib/gemcitabine , while tolerated , did not provide survival benefit over gemcitabine alone in patients with advanced pancreatic cancer from Japan or other regions .", "sentence_id": 11}
+{"abstract_id": "24507404", "label": "objective", "text": "Bypass Angioplasty Revascularization Investigation @ Diabetes ( BARI @D ) was a study of management strategies for diabetic patients with myocardial ischemia and coronary artery disease .", "sentence_id": 0}
+{"abstract_id": "24507404", "label": "objective", "text": "In a @ design , early revascularization versus medical management with or without late revascularization and insulin sensitization versus insulin provision were examined .", "sentence_id": 1}
+{"abstract_id": "24507404", "label": "objective", "text": "No advantage for either strategy was seen , except in the group undergoing early coronary artery bypass grafting ( CABG ) .", "sentence_id": 2}
+{"abstract_id": "24507404", "label": "objective", "text": "In that group , a reduction in subsequent myocardial infarction was noted .", "sentence_id": 3}
+{"abstract_id": "24507404", "label": "objective", "text": "The purpose of our report was to characterize the conduct and short-term outcomes for CABG that led to this result .", "sentence_id": 4}
+{"abstract_id": "24507404", "label": "methods", "text": "Data from the BARI @D CABG stratum were collected , including the baseline demographic and cardiovascular characteristics , technical details of the operation , and perioperative morbidity and mortality , and analyzed .", "sentence_id": 5}
+{"abstract_id": "24507404", "label": "results", "text": "A total of @ patients were studied .", "sentence_id": 6}
+{"abstract_id": "24507404", "label": "results", "text": "The average cardiac function was normal , and most had multivessel disease .", "sentence_id": 7}
+{"abstract_id": "24507404", "label": "results", "text": "Almost all had undergone CABG by way of a median sternotomy using an internal mammary artery , and one third were off pump .", "sentence_id": 8}
+{"abstract_id": "24507404", "label": "results", "text": "The perioperative morbidity and mortality were low and compared well with larger outcomes databases .", "sentence_id": 9}
+{"abstract_id": "24507404", "label": "conclusions", "text": "BARI @D showed that early CABG in patients with type @ diabetes and myocardial ischemia and multivessel disease reduced the subsequent myocardial infarction rates .", "sentence_id": 10}
+{"abstract_id": "24507404", "label": "conclusions", "text": "The present results have demonstrated that this was achieved using off-pump surgery in certain cases , standard myocardial protection , and routine use of the internal mammary artery or other arterial grafts .", "sentence_id": 11}
+{"abstract_id": "25236611", "label": "background", "text": "Interpretive front-of-pack nutrition labels are better understood than non-interpretive labels .", "sentence_id": 0}
+{"abstract_id": "25236611", "label": "background", "text": "However , robust evidence on the effects of such labels on consumer food purchases in the real-world is lacking .", "sentence_id": 1}
+{"abstract_id": "25236611", "label": "background", "text": "Our aim is to assess the effects of two interpretive front-of-pack nutrition labels , compared with a non-interpretive label , on the healthiness of consumer food purchases .", "sentence_id": 2}
+{"abstract_id": "25236611", "label": "methods", "text": "A five-week ( @-week baseline and @-week intervention ) three-arm parallel randomised controlled trial will be conducted using a bespoke smartphone application , which will administer study questionnaires and deliver intervention ( Multiple Traffic Light and Health Star Rating ) and control ( Nutrition Information Panel ) labels .", "sentence_id": 3}
+{"abstract_id": "25236611", "label": "methods", "text": "To view their allocated nutrition label , participants scan the barcode of packaged food products using their smartphone camera .", "sentence_id": 4}
+{"abstract_id": "25236611", "label": "methods", "text": "The assigned label is displayed instantly on the smartphone screen @ eligible participants ( New Zealand adult smartphone owners who shop in a supermarket at least once a week and are main household shoppers ) will be randomised in a @:@:@ ratio to one of the three nutrition label formats , using computer-generated randomisation sequences .", "sentence_id": 5}
+{"abstract_id": "25236611", "label": "methods", "text": "Randomisation will be stratified by ethnicity and interest in healthy eating .", "sentence_id": 6}
+{"abstract_id": "25236611", "label": "methods", "text": "Food and beverage purchase data will be collected continuously throughout the study via hard copy till receipts and electronic grocery purchase lists recorded and transmitted using the smartphone application .", "sentence_id": 7}
+{"abstract_id": "25236611", "label": "methods", "text": "The primary outcome will be healthiness of food purchases in each trial arm , assessed as mean Food Standards Australia New Zealand nutrient profiling score criterion score for all food and beverages purchased over the intervention period .", "sentence_id": 8}
+{"abstract_id": "25236611", "label": "methods", "text": "Secondary outcomes will include saturated fat , sugar , sodium and energy content of food purchases ; food expenditure ; labelling profile of food purchases ( i.e. mean number of Health Star Rating stars and proportion of red , green and amber traffic lights ) ; nutrient profiling score over time and by food categories ; purchases of unpackaged foods ; self-reported nutrition knowledge and recorded use of assigned labelling system .", "sentence_id": 9}
+{"abstract_id": "25236611", "label": "conclusions", "text": "The Starlight randomised , controlled trial will determine the effects of interpretive front-of-pack nutrition labels on the healthiness of consumer food purchases in the real world .", "sentence_id": 10}
+{"abstract_id": "24884942", "label": "background", "text": "A gene-based estimate of lung cancer risk in smokers has been shown to act as a smoking cessation motivator in hospital recruited subjects .", "sentence_id": 0}
+{"abstract_id": "24884942", "label": "background", "text": "The objective of this trial is to determine if this motivator is as effective in subjects recruited from an NHS primary care unit .", "sentence_id": 1}
+{"abstract_id": "24884942", "label": "methods", "text": "Subjects will be recruited by mailings using smoking entries on the GP electronic data-base ( total practice population = @,@ ) to identify smokers who may want to quit .", "sentence_id": 2}
+{"abstract_id": "24884942", "label": "methods", "text": "Smoking cessation clinics based on medical centre premises will run for eight weeks .", "sentence_id": 3}
+{"abstract_id": "24884942", "label": "methods", "text": "Clinics will be randomised to have the gene-based test for estimation of lung cancer risk or to act as controls groups .", "sentence_id": 4}
+{"abstract_id": "24884942", "label": "methods", "text": "The primary endpoint will be smoking cessation at eight weeks and six months .", "sentence_id": 5}
+{"abstract_id": "24884942", "label": "methods", "text": "Secondary outcomes will include ranking of the gene-based test with other smoking cessation motivators .", "sentence_id": 6}
+{"abstract_id": "24884942", "label": "conclusions", "text": "The results will inform as to whether the gene-based test is both effective as motivator and acceptable to subjects recruited from primary care .", "sentence_id": 7}
+{"abstract_id": "25537303", "label": "background", "text": "Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration .", "sentence_id": 0}
+{"abstract_id": "25537303", "label": "background", "text": "However , clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats .", "sentence_id": 1}
+{"abstract_id": "25537303", "label": "objective", "text": "To compare the effect of PO administered famotidine , fractionated omeprazole tablet ( fOT ) , and omeprazole reformulated paste ( ORP ) on intragastric pH in cats .", "sentence_id": 2}
+{"abstract_id": "25537303", "label": "objective", "text": "We hypothesized that both omeprazole formulations would be superior to famotidine and placebo .", "sentence_id": 3}
+{"abstract_id": "25537303", "label": "methods", "text": "Six healthy adult DSH colony cats .", "sentence_id": 4}
+{"abstract_id": "25537303", "label": "methods", "text": "Utilizing a randomized , @-way crossover design , cats received @-@ @ mg/kg PO q@h fOT , ORP , famotidine , and placebo ( lactose capsules ) .", "sentence_id": 5}
+{"abstract_id": "25537303", "label": "methods", "text": "Intragastric pH monitoring was used to continuously record intragastric pH for @ hours beginning on day @ of treatment .", "sentence_id": 6}
+{"abstract_id": "25537303", "label": "methods", "text": "Plasma omeprazole concentrations at steady state ( day @ ) were determined by high performance liquid chromatography ( HPLC ) with ultraviolet detection .", "sentence_id": 7}
+{"abstract_id": "25537303", "label": "methods", "text": "Mean percentage time that intragastric pH was @ and @ were compared among groups using ANOVA with a posthoc Tukey-Kramer test ( = @ ) .", "sentence_id": 8}
+{"abstract_id": "25537303", "label": "results", "text": "The mean percentage time SD that intragastric pH was @ was @ @ % for fOT , @ @ % for ORP , @ @ % for famotidine , and @ @ % for placebo .", "sentence_id": 9}
+{"abstract_id": "25537303", "label": "results", "text": "Mean SD plasma omeprazole concentrations were similar in cats receiving fOT compared to those receiving ORP and in a range associated with acid suppression reported in other studies .", "sentence_id": 10}
+{"abstract_id": "25537303", "label": "conclusions", "text": "These results suggest that both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo .", "sentence_id": 11}
+{"abstract_id": "25537303", "label": "conclusions", "text": "Fractionated enteric-coated OT is an effective acid suppressant despite disruption of the enteric coating .", "sentence_id": 12}
+{"abstract_id": "24335016", "label": "background", "text": "Recent publications show that heat-mediated tissue tightening is a promising treatment for the lax abdomen and may provide better long-term outcomes than traditional suction-assisted liposuction ( SAL ) .", "sentence_id": 0}
+{"abstract_id": "24335016", "label": "objective", "text": "The author evaluates the degree and duration of skin surface area contraction , as well as the influence of anatomic location of the treatment region on the degree of tissue tightening , in a study comparing SAL alone vs SAL plus radiofrequency-assisted liposuction ( RFAL ) .", "sentence_id": 1}
+{"abstract_id": "24335016", "label": "methods", "text": "In this prospective , randomized , split abdominal study , @ consecutive patients were treated with SAL alone on @ side and with SAL plus RFAL on the other side .", "sentence_id": 2}
+{"abstract_id": "24335016", "label": "methods", "text": "Each patient had @ ( @ @-cm ) squares-@ per treatment type-tattooed in the lower abdominal region ( @ on the right and @ on the left ) .", "sentence_id": 3}
+{"abstract_id": "24335016", "label": "methods", "text": "The surface area of these squares was measured with the Vectra computerized measurement system ( Canfield , Inc , Fairfield , New Jersey ) at pretreatment , at @ weeks posttreatment , and at @ year posttreatment .", "sentence_id": 4}
+{"abstract_id": "24335016", "label": "methods", "text": "All measurements were subjected to statistical analysis using predictive analytic software and were evaluated for statistical significance .", "sentence_id": 5}
+{"abstract_id": "24335016", "label": "results", "text": "In regions treated with SAL alone , there was a @ % mean skin surface area contraction at @ weeks and @ % at @ year posttreatment .", "sentence_id": 6}
+{"abstract_id": "24335016", "label": "results", "text": "The mean skin surface area reduction was @ % in regions treated with radiofrequency plus SAL at @ weeks and at @ year .", "sentence_id": 7}
+{"abstract_id": "24335016", "label": "results", "text": "The anatomic location of each square ( medial vs lateral ) did not statistically correlate with more or less tissue tightening .", "sentence_id": 8}
+{"abstract_id": "24335016", "label": "conclusions", "text": "Radiofrequency-assisted tissue tightening , when applied in conjunction with SAL , is effective in achieving greater skin surface area reduction .", "sentence_id": 9}
+{"abstract_id": "25431855", "label": "objective", "text": "Inhalation therapy is the main treatment for asthma and its adequate use has been a factor responsible for disease control ; therefore , the aim of the study was to determine whether a digital media tool , which features portability on mobile phones , modifies the assimilation of the inhalation technique .", "sentence_id": 0}
+{"abstract_id": "25431855", "label": "methods", "text": "A total of @ professionals working in the health care area with the pediatric population were selected .", "sentence_id": 1}
+{"abstract_id": "25431855", "label": "methods", "text": "They were submitted to a pre-test on their knowledge of inhalation therapy .", "sentence_id": 2}
+{"abstract_id": "25431855", "label": "methods", "text": "The professionals were randomized into two groups ( A and B ) .", "sentence_id": 3}
+{"abstract_id": "25431855", "label": "methods", "text": "Group A received a media application on their mobile phones showing the steps of inhalation therapy , while group B received the same information in written form only .", "sentence_id": 4}
+{"abstract_id": "25431855", "label": "methods", "text": "A post-test was applied after @ days .", "sentence_id": 5}
+{"abstract_id": "25431855", "label": "methods", "text": "The results ( pre - and post - ) were analyzed by two pediatric pulmonologists .", "sentence_id": 6}
+{"abstract_id": "25431855", "label": "results", "text": "Of the @ professionals , @ % were females .", "sentence_id": 7}
+{"abstract_id": "25431855", "label": "results", "text": "Of a total possible score of ten , the mean score obtained in the pre-test was @ @ , and in the second test , @ @ ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25431855", "label": "results", "text": "There were no significant differences when comparing the two groups ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25431855", "label": "results", "text": "The nurses had the lowest mean scores in the initial test ( @ @ ) ; however , they were the group that learned the most with the intervention , showing similar means to those of other groups in the second test ( @ @ ) .", "sentence_id": 10}
+{"abstract_id": "25431855", "label": "conclusions", "text": "There was significant improvement in knowledge about inhalation therapy in all professional categories using both methods , demonstrating that education , when available to professionals , positively modifies medical practice .", "sentence_id": 11}
+{"abstract_id": "24625934", "label": "background", "text": "Succinylcholine a depolarizing muscle relaxant with rapid onset , predictable course and short duration of action is associated with myalgia .", "sentence_id": 0}
+{"abstract_id": "24625934", "label": "objective", "text": "The aim of this study is to evaluate the efficacy of pregabalin , gabapentin and diclofenac on the incidence and severity of succinylcholine-induced myalgia .", "sentence_id": 1}
+{"abstract_id": "24625934", "label": "methods", "text": "Tertiary Care Teaching Hospital .", "sentence_id": 2}
+{"abstract_id": "24625934", "label": "methods", "text": "A total of @ patients undergoing laparoscopic cholecystectomy were randomly assigned into three groups : Pregabalin group received @ mg of pregabalin , gabapentin group received @ mg of gabapentin and diclofenac group received @ mg of diclofenac sodium orally @ h prior to surgery .", "sentence_id": 3}
+{"abstract_id": "24625934", "label": "methods", "text": "Anesthesia was induced with fentanyl @ g/kg , propofol @-@ @ mg/kg and succinylcholine @ mg/kg and was maintained with oxygen with sevoflurane in the air and intermittent vecuronium bromide .", "sentence_id": 4}
+{"abstract_id": "24625934", "label": "methods", "text": "A blinded observer recorded post-operative pain scores on visual analog scale at different time intervals and myalgia at @ h. Post-operative pain relief was provided with fentanyl based patient-controlled analgesia .", "sentence_id": 5}
+{"abstract_id": "24625934", "label": "methods", "text": "Fentanyl consumption in @ h was recorded as a primary outcome .", "sentence_id": 6}
+{"abstract_id": "24625934", "label": "methods", "text": "Patients ' characteristics and total fentanyl consumption were compared using one-way ANOVA followed by post-hoc test .", "sentence_id": 7}
+{"abstract_id": "24625934", "label": "methods", "text": "Pain score was compared amongst the groups using Kruskal Wallis test .", "sentence_id": 8}
+{"abstract_id": "24625934", "label": "results", "text": "The myalgia occurred in @ , @ and @ patients in pregabalin , gabapentin and diclofenac sodium group respectively ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24625934", "label": "results", "text": "Patients in diclofenac group had significantly higher fentanyl consumption ( @ @ g ) compared with pregabalin group ( @ @ g ) ( @ % confidence interval -LSB- CI -RSB- = @-@ @ ) and gabapentin group ( @ @ g ) ( @ % CI = @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24625934", "label": "results", "text": "However , there was no significant difference in fentanyl consumption between pregabalin and gabapentin groups ( @ % CI = -@ -@ ) .", "sentence_id": 11}
+{"abstract_id": "24625934", "label": "results", "text": "There was a significant difference in visual analog score at time points @ , @ and @ h among the study groups .", "sentence_id": 12}
+{"abstract_id": "24625934", "label": "conclusions", "text": "Pre-treatment with pregabalin , gabapentin and diclofenac had equal efficacy in reducing the incidence and severity of succinylcholine-induced myalgia .", "sentence_id": 13}
+{"abstract_id": "24625934", "label": "conclusions", "text": "However , pre-treatment with pregabalin and gabapentin decreased post-operative pain scores and fentanyl consumption .", "sentence_id": 14}
+{"abstract_id": "25488084", "label": "objective", "text": "To undertake a five year follow up of a cohort of women and children delivered by forceps or vacuum extractor in a randomised controlled study .", "sentence_id": 0}
+{"abstract_id": "25488084", "label": "methods", "text": "Follow up of a randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25488084", "label": "methods", "text": "District general hospital in the West Midlands .", "sentence_id": 2}
+{"abstract_id": "25488084", "label": "methods", "text": "Follow up questionnaires were sent to @ of the @ women originally recruited at the North Staffordshire Hospital to a randomised controlled study comparing forceps and vacuum extractor for assisted delivery .", "sentence_id": 3}
+{"abstract_id": "25488084", "label": "methods", "text": "Two hundred and twenty-eight women responded ( @ % ) and all were included in the study ; forceps ( n = @ ) and vacuum extractor ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25488084", "label": "methods", "text": "Bowel and urinary dysfunction , child vision assessment , and child development .", "sentence_id": 5}
+{"abstract_id": "25488084", "label": "results", "text": "Maternal adverse symptoms at long term follow up were relatively common .", "sentence_id": 6}
+{"abstract_id": "25488084", "label": "results", "text": "Urinary incontinence of various severity was reported by @ % , bowel habit urgency was reported by @ % ( @/@ ) , and loss of bowel control ` sometimes ' or ` frequently ' by @ % of women ( @/@ ) .", "sentence_id": 7}
+{"abstract_id": "25488084", "label": "results", "text": "No significant differences between instruments were found in terms of either bowel or urinary dysfunction .", "sentence_id": 8}
+{"abstract_id": "25488084", "label": "results", "text": "Overall , @ % ( @/@ ) of children were noted to have visual problems .", "sentence_id": 9}
+{"abstract_id": "25488084", "label": "results", "text": "There was no significant difference in visual function between the two groups : ventouse @/@ ( @ % ) , compared with forceps @/@ ( @ % ) ; odds ratio @ , @ % CI @-@ @ .", "sentence_id": 10}
+{"abstract_id": "25488084", "label": "results", "text": "Of the @ children with visual problems , a family history was known in @ , and @/@ ( @ % ) had a positive family history for visual problems .", "sentence_id": 11}
+{"abstract_id": "25488084", "label": "results", "text": "No significant differences in child development were found between the two groups .", "sentence_id": 12}
+{"abstract_id": "25488084", "label": "conclusions", "text": "There is no evidence to suggest that at five years after delivery use of the ventouse or forceps has specific maternal or child benefits or side effects .", "sentence_id": 13}
+{"abstract_id": "24818633", "label": "background", "text": "Recently , we documented the likely non-inferiority of Combinatietherapie Bij Reumatode Artritis ( COBRA ) - light therapy ( methotrexate increased to @mg/week with initial prednisolone @mg/day ) compared with the original COBRA therapy ( methotrexate @ mg/week , sulfasalazine @g/day , with initial prednisolone @mg/day ) after @weeks in patients with early active rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "24818633", "label": "objective", "text": "To assess the non-inferiority of COBRA-light versus COBRA after @year in terms of disease activity ( DAS@ ) , functional outcome ( Health Assessment Questionnaire ( HAQ ) ) and radiographic progression ( Sharp/van der Heijde score ( SHS ) ) , and to assess the effect of adding etanercept .", "sentence_id": 1}
+{"abstract_id": "24818633", "label": "methods", "text": "An open-label , randomised controlled , non-inferiority trial of @ patients with active early RA , following a treat-to-target protocol incorporating the addition of etanercept if DAS@ @ at weeks @ or @ .", "sentence_id": 2}
+{"abstract_id": "24818633", "label": "results", "text": "Both groups showed major improvements in DAS@ after @weeks : mean ( SD ) -@ ( @ ) in the COBRA and -@ ( @ ) in the COBRA-light group ( p = ns ) .", "sentence_id": 3}
+{"abstract_id": "24818633", "label": "results", "text": "In both groups , functional ability improved and radiological progression of joints was minimal .", "sentence_id": 4}
+{"abstract_id": "24818633", "label": "results", "text": "At least one adverse event was reported in @ % of the patients in both groups .", "sentence_id": 5}
+{"abstract_id": "24818633", "label": "results", "text": "In total , @ serious adverse events occurred : @ vs @ in COBRA and COBRA-light , respectively .", "sentence_id": 6}
+{"abstract_id": "24818633", "label": "results", "text": "Treatment actually instituted was often less intensive than required by the protocol : of the total population , @ patients ( @ % ) required etanercept ( more in the COBRA-light group ) , but only @ of these ( @ % ) actually received it .", "sentence_id": 7}
+{"abstract_id": "24818633", "label": "conclusions", "text": "Intensive COBRA or COBRA-light therapy has major , comparably favourable effects on disease activity , functional ability and radiological outcome after @year in patients with early RA .", "sentence_id": 8}
+{"abstract_id": "24818633", "label": "conclusions", "text": "Protocolised addition of etanercept was often not implemented by treating rheumatologists , and patients receiving it appeared to have limited added benefit , probably because of low disease activity levels at its initiation .", "sentence_id": 9}
+{"abstract_id": "24468198", "label": "objective", "text": "This study compared time-to-hospitalization among subjects enrolled in different diabetes self-management programs ( DSMP ) .", "sentence_id": 0}
+{"abstract_id": "24468198", "label": "objective", "text": "We sought to determine whether the interventions delayed the occurrence of any acute event necessitating hospitalization .", "sentence_id": 1}
+{"abstract_id": "24468198", "label": "methods", "text": "Electronic medical records ( EMR ) were obtained for @ adults enrolled in a randomized controlled trial ( RCT ) of Type @ diabetes ( T@DM ) self-management programs .", "sentence_id": 2}
+{"abstract_id": "24468198", "label": "methods", "text": "All study participants had uncontrolled diabetes and were randomized into either : personal digital assistant ( PDA ) , Chronic Disease Self-Management Program ( CDSMP ) , combined PDA and CDSMP ( COM ) , or usual care ( UC ) groups .", "sentence_id": 3}
+{"abstract_id": "24468198", "label": "methods", "text": "Subjects were followed for a maximum of two years .", "sentence_id": 4}
+{"abstract_id": "24468198", "label": "methods", "text": "Time-to-hospitalization was measured as the interval between study enrollment and the occurrence of a diabetes-related hospitalization .", "sentence_id": 5}
+{"abstract_id": "24468198", "label": "results", "text": "Subjects enrolled in the CDSMP-only arm had significantly prolonged time-to-hospitalization ( Hazard ratio : @ ; p = @ ) when compared to subjects in the control arm .", "sentence_id": 6}
+{"abstract_id": "24468198", "label": "results", "text": "Subjects in the PDA-only and combined PDA and CDSMP arms showed no improvements in comparison to the control arm .", "sentence_id": 7}
+{"abstract_id": "24468198", "label": "conclusions", "text": "CDSMP can be effective in delaying time-to-hospitalization among patients with T@DM .", "sentence_id": 8}
+{"abstract_id": "24468198", "label": "conclusions", "text": "Reducing unnecessary healthcare utilization , particularly inpatient hospitalization is a key strategy to improving the quality of health care and lowering associated health care costs .", "sentence_id": 9}
+{"abstract_id": "24468198", "label": "conclusions", "text": "The CDSMP offers the potential to reduce time-to-hospitalization among T@DM patients .", "sentence_id": 10}
+{"abstract_id": "25788230", "label": "background", "text": "The benefit of CT coronary angiography ( CTCA ) in patients presenting with stable chest pain has not been systematically studied .", "sentence_id": 0}
+{"abstract_id": "25788230", "label": "background", "text": "We aimed to assess the effect of CTCA on the diagnosis , management , and outcome of patients referred to the cardiology clinic with suspected angina due to coronary heart disease .", "sentence_id": 1}
+{"abstract_id": "25788230", "label": "methods", "text": "In this prospective open-label , parallel-group , multicentre trial , we recruited patients aged @-@ years referred for the assessment of suspected angina due to coronary heart disease from @ cardiology chest pain clinics across Scotland .", "sentence_id": 2}
+{"abstract_id": "25788230", "label": "methods", "text": "We randomly assigned ( @:@ ) participants to standard care plus CTCA or standard care alone .", "sentence_id": 3}
+{"abstract_id": "25788230", "label": "methods", "text": "Randomisation was done with a web-based service to ensure allocation concealment .", "sentence_id": 4}
+{"abstract_id": "25788230", "label": "methods", "text": "The primary endpoint was certainty of the diagnosis of angina secondary to coronary heart disease at @ weeks .", "sentence_id": 5}
+{"abstract_id": "25788230", "label": "methods", "text": "All analyses were intention to treat , and patients were analysed in the group they were allocated to , irrespective of compliance with scanning .", "sentence_id": 6}
+{"abstract_id": "25788230", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "25788230", "label": "results", "text": "Between Nov @ , @ , and Sept @ , @ , we randomly assigned @ ( @ % ) of @ patients who had been referred for assessment of suspected angina due to coronary heart disease .", "sentence_id": 8}
+{"abstract_id": "25788230", "label": "results", "text": "@ % of participants had a baseline clinic diagnosis of coronary heart disease and @ % had angina due to coronary heart disease .", "sentence_id": 9}
+{"abstract_id": "25788230", "label": "results", "text": "At @ weeks , CTCA reclassified the diagnosis of coronary heart disease in @ ( @ % ) patients and the diagnosis of angina due to coronary heart disease in @ ( @ % ) patients ( standard care @ -LSB- @ % -RSB- and @ -LSB- @ % -RSB- ; p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25788230", "label": "results", "text": "Although both the certainty ( relative risk -LSB- RR -RSB- @ , @ % CI @-@ ; p < @ ) and frequency of coronary heart disease increased ( @ , @-@ ; p = @ ) , the certainty increased ( @ , @-@ ; p < @ ) and frequency seemed to decrease ( @ , @-@ ; p = @ ) for the diagnosis of angina due to coronary heart disease .", "sentence_id": 11}
+{"abstract_id": "25788230", "label": "results", "text": "This changed planned investigations ( @ % vs @ % ; p < @ ) and treatments ( @ % vs @ % ; p < @ ) but did not affect @-week symptom severity or subsequent admittances to hospital for chest pain .", "sentence_id": 12}
+{"abstract_id": "25788230", "label": "results", "text": "After @ years , CTCA was associated with a @ % reduction in fatal and non-fatal myocardial infarction ( @ vs @ , HR @ , @ % CI @-@ ; p = @ ) , but this was not significant .", "sentence_id": 13}
+{"abstract_id": "25788230", "label": "conclusions", "text": "In patients with suspected angina due to coronary heart disease , CTCA clarifies the diagnosis , enables targeting of interventions , and might reduce the future risk of myocardial infarction .", "sentence_id": 14}
+{"abstract_id": "24392486", "label": "objective", "text": "To evaluate the effect of different polymerization sequences employed during application of bis-GMAbased particulate filler composites ( PFC ) or a flowable resin ( FR ) on fiber-reinforced composite ( FRC ) .", "sentence_id": 0}
+{"abstract_id": "24392486", "label": "methods", "text": "Unidirectional , pre-impregnated S@-glass fibers ( Dentapreg ) and multidirectional preimpregnated E-glass fibers ( Dentapreg ) ( length : @ mm ; thickness : @ mm ) were obtained ( N = @ , n = @ per group ) and embedded in translucent silicone material with the adhesion surface exposed .", "sentence_id": 1}
+{"abstract_id": "24392486", "label": "methods", "text": "The resulting specimens were randomly divided into @ groups for the following application sequences : a ) FRC+PFC ( photopolymerized in one step ) , b ) FRC+FR ( photopolymerized in one step ) , c ) FRC+PFC ( photopolymerized individually ) , d ) FRC+FR ( photopolymerized individually ) , e ) FRC ( photopolymerized ) + intermediate adhesive resin and PFC ( photopolymerized in one step ) , f ) FRC ( photopolymerized ) + intermediate adhesive resin and FR ( photopolymerized in one step ) .", "sentence_id": 2}
+{"abstract_id": "24392486", "label": "methods", "text": "The sequences of unidirectional ( groups a to f ) were repeated for multidirectional ( groups g to l ) FRCs .", "sentence_id": 3}
+{"abstract_id": "24392486", "label": "methods", "text": "PFCs were debonded from the FRC surfaces using the shear bond test in a universal testing machine ( @ mm/min ) .", "sentence_id": 4}
+{"abstract_id": "24392486", "label": "methods", "text": "On additional specimens from each FRC type , thermogravimetric analysis ( TGA ) was performed to characterize the fiber weight content ( Wf ) ( N = @ , n = @ per group ) .", "sentence_id": 5}
+{"abstract_id": "24392486", "label": "methods", "text": "After debonding , all specimens were analyzed using SEM to categorize the failure modes .", "sentence_id": 6}
+{"abstract_id": "24392486", "label": "methods", "text": "The data were statistically analyzed using @-way ANOVA and Tukey 's tests ( = @ ) .", "sentence_id": 7}
+{"abstract_id": "24392486", "label": "results", "text": "Significant effects of the FRC type ( S@ or E-glass ) ( p < @ ) , resin type ( PFC or FR ) ( p < @ ) and polymerization protocol ( p < @ ) were observed on the bond strength ( MPa ) .", "sentence_id": 8}
+{"abstract_id": "24392486", "label": "results", "text": "Interaction terms were also significant ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24392486", "label": "results", "text": "The multidirectional FRC groups ( g to l ) showed significantly lower bond strengths ( @ @ to @ @ MPa ) than did the unidirectional FRC groups ( a to f ) ( @ @ to @ @ MPa ) .", "sentence_id": 10}
+{"abstract_id": "24392486", "label": "results", "text": "Among the unidirectional FRC groups , the highest values were obtained with protocol f ( @ @ ) , followed by protocol e ( @ @ ) .", "sentence_id": 11}
+{"abstract_id": "24392486", "label": "results", "text": "PFC adhesion to unidirectional FRC was lower when FRC and PFC were polymerized in one step ( protocol a : @ @ ) than individual polymerization ( protocol c : @ @ ) .", "sentence_id": 12}
+{"abstract_id": "24392486", "label": "results", "text": "The opposite situation was true for FR ( protocol b : @ @ ; protocol d : @ @ ) .", "sentence_id": 13}
+{"abstract_id": "24392486", "label": "results", "text": "Groups a to f presented exclusively mixed failures ( a combination of partial cohesive failure in the PFC and adhesive failure between the FRC and PFC ) and groups g to l demonstrated only adhesive failure ( intact FRC no cohesive failure of PFC ) .", "sentence_id": 14}
+{"abstract_id": "24392486", "label": "results", "text": "TGA revealed @ @ wt % fiber content for multidirectional and @ @ wt % for unidirectional FRCs tested .", "sentence_id": 15}
+{"abstract_id": "24392486", "label": "conclusions", "text": "Multidirectional pre-impregnated E-glass fibers can not be recommended in combination with the PFC and FR materials tested in this study .", "sentence_id": 16}
+{"abstract_id": "24392486", "label": "conclusions", "text": "Application of an intermediate adhesive resin layer increases the adhesion of both PFC and FR to unidirectional FRC .", "sentence_id": 17}
+{"abstract_id": "24392486", "label": "conclusions", "text": "FRC and FR can be polymerized in one step , but FRC and PFC combinations should be polymerized individually .", "sentence_id": 18}
+{"abstract_id": "25074387", "label": "background", "text": "Medium chain triglycerides ( MCT ) enhance thermogenesis and may reduce food intake relative to long chain triglycerides ( LCT ) .", "sentence_id": 0}
+{"abstract_id": "25074387", "label": "background", "text": "The goal of this study was to establish the effects of MCT on appetite and food intake and determine whether differences were due to differences in hormone concentrations .", "sentence_id": 1}
+{"abstract_id": "25074387", "label": "methods", "text": "Two randomized , crossover studies were conducted in which overweight men consumed @g of MCT or corn oil ( LCT ) at breakfast .", "sentence_id": 2}
+{"abstract_id": "25074387", "label": "methods", "text": "Blood samples were obtained over @h .", "sentence_id": 3}
+{"abstract_id": "25074387", "label": "methods", "text": "In Study @ ( n = @ ) , an ad lib lunch was served after @h .", "sentence_id": 4}
+{"abstract_id": "25074387", "label": "methods", "text": "In Study @ ( n = @ ) , a preload containing @g of test oil was given at @h and lunch was served @h later .", "sentence_id": 5}
+{"abstract_id": "25074387", "label": "methods", "text": "Linear mixed model analyses were performed to determine the effects of MCT and LCT oil on change in hormones and metabolites from fasting , adjusting for body weight .", "sentence_id": 6}
+{"abstract_id": "25074387", "label": "methods", "text": "Correlations were computed between differences in hormones just before the test meals and differences in intakes after the two oils for Study @ only .", "sentence_id": 7}
+{"abstract_id": "25074387", "label": "results", "text": "Food intake at the lunch test meal after the MCT preload ( Study @ ) was ( means.e.m . )", "sentence_id": 8}
+{"abstract_id": "25074387", "label": "results", "text": "@kcal vs @kcal after LCT ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25074387", "label": "results", "text": "MCT consumption resulted in a lower rise in triglycerides ( P = @ ) and glucose ( P = @ ) and a higher rise in peptide YY ( PYY , P = @ ) and leptin ( P = @ ) compared with LCT ( combined data ) .", "sentence_id": 10}
+{"abstract_id": "25074387", "label": "results", "text": "Correlations between differences in hormone levels ( glucagon-like peptide ( GLP-@ ) , PYY ) and differences in food intake were in the opposite direction to expectations .", "sentence_id": 11}
+{"abstract_id": "25074387", "label": "conclusions", "text": "MCT consumption reduced food intake acutely but this does not seem to be mediated by changes in GLP-@ , PYY and insulin .", "sentence_id": 12}
+{"abstract_id": "25304255", "label": "background", "text": "High-risk prescribing in primary care is common and causes considerable harm .", "sentence_id": 0}
+{"abstract_id": "25304255", "label": "background", "text": "Feedback interventions have small/moderate effects on clinical practice , but few trials explicitly compare different forms of feedback .", "sentence_id": 1}
+{"abstract_id": "25304255", "label": "background", "text": "There is growing recognition that intervention development should be theory-informed , and that comprehensive reporting of intervention design is required by potential users of trial findings .", "sentence_id": 2}
+{"abstract_id": "25304255", "label": "background", "text": "The paper describes intervention development for the Effective Feedback to Improve Primary Care Prescribing Safety ( EFIPPS ) study , a pragmatic three-arm cluster randomised trial in @ Scottish general practices .", "sentence_id": 3}
+{"abstract_id": "25304255", "label": "methods", "text": "The NHS chose to implement a feedback intervention to utilise a new resource , new Prescribing Information System ( newPIS ) .", "sentence_id": 4}
+{"abstract_id": "25304255", "label": "methods", "text": "The development phase required selection of high-risk prescribing outcome measures and design of intervention components : ( @ ) educational material ( the usual care comparison ) , ( @ ) feedback of practice rates of high-risk prescribing received by both intervention arms and ( @ ) a theory-informed behaviour change component to be received by one intervention arm .", "sentence_id": 5}
+{"abstract_id": "25304255", "label": "methods", "text": "Outcome measures , educational material and feedback design , were developed with a National Health Service Advisory Group .", "sentence_id": 6}
+{"abstract_id": "25304255", "label": "methods", "text": "The behaviour change component was informed by the Theory of Planned Behaviour and the Health Action Process Approach .", "sentence_id": 7}
+{"abstract_id": "25304255", "label": "methods", "text": "A focus group elicitation study and an email Delphi study with general practitioners ( GPs ) identified key attitudes and barriers of responding to the prescribing feedback .", "sentence_id": 8}
+{"abstract_id": "25304255", "label": "methods", "text": "Behaviour change techniques were mapped to the psychological constructs , and the content was informed by the results of the elicitation and Delphi study .", "sentence_id": 9}
+{"abstract_id": "25304255", "label": "results", "text": "Six high-risk prescribing measures were selected in a consensus process based on importance and feasibility .", "sentence_id": 10}
+{"abstract_id": "25304255", "label": "results", "text": "Educational material and feedback design were based on current NHS Scotland practice and Advisory Group recommendations .", "sentence_id": 11}
+{"abstract_id": "25304255", "label": "results", "text": "The behaviour change component was resource constrained in development , mirroring what is feasible in an NHS context .", "sentence_id": 12}
+{"abstract_id": "25304255", "label": "results", "text": "Four behaviour change interventions were developed and embedded in five quarterly rounds of feedback targeting attitudes , subjective norms , perceived behavioural control and action planning ( @ ) .", "sentence_id": 13}
+{"abstract_id": "25304255", "label": "conclusions", "text": "The paper describes a process which is feasible to use in the resource-constrained environment of NHS-led intervention development and documents the intervention to make its design and implementation explicit to potential users of the trial findings .", "sentence_id": 14}
+{"abstract_id": "25409167", "label": "objective", "text": "Rectal nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence of postendoscopic retrograde cholangiopancreatography ( ERCP ) pancreatitis ( PEP ) .", "sentence_id": 0}
+{"abstract_id": "25409167", "label": "objective", "text": "The aim of this study was to determine whether intramuscular diclofenac reduces the risk of PEP .", "sentence_id": 1}
+{"abstract_id": "25409167", "label": "methods", "text": "Patients who underwent ERCP were randomized to receive either @mg of diclofenac or placebo by intramuscular injection immediately after the procedure .", "sentence_id": 2}
+{"abstract_id": "25409167", "label": "methods", "text": "PEP was defined as elevated serum amylase levels ( at least three times the upper limit of normal @ hours after the procedure ) associated with new or worsened upper abdominal , epigastric , or back pain .", "sentence_id": 3}
+{"abstract_id": "25409167", "label": "results", "text": "In total , @ patients were randomized , and @ were eligible for analysis .", "sentence_id": 4}
+{"abstract_id": "25409167", "label": "results", "text": "The two groups were similar regarding clinical and demographic factors , as well as patient - and procedure-related risk factors for PEP .", "sentence_id": 5}
+{"abstract_id": "25409167", "label": "results", "text": "PEP developed in @/@ patients ( @ % ) in the placebo group and in @/@ patients ( @ % ) in the diclofenac group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25409167", "label": "results", "text": "Multivariate regression analysis failed to illustrate that intramuscular diclofenac prevented PEP ( odds ratio @ ; @ % confidence interval @-@ @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25409167", "label": "conclusions", "text": "Prophylactic intramuscular diclofenac had no beneficial preventive effect on PEP.Clinicaltrials.gov NCT@ .", "sentence_id": 8}
+{"abstract_id": "25891548", "label": "background", "text": "Infusion of PDA-@ , a preparation of mesenchymal-like cells derived from full-term human placenta , is a new approach in the treatment of patients with multiple sclerosis .", "sentence_id": 0}
+{"abstract_id": "25891548", "label": "objective", "text": "This safety study aimed to rule out the possibility of paradoxical exacerbation of disease activity by PDA-@ in patients with multiple sclerosis .", "sentence_id": 1}
+{"abstract_id": "25891548", "label": "methods", "text": "This was a phase @b , multicenter , randomized , double-blind , placebo-controlled , @-dose ranging study including patients with relapsing-remitting multiple sclerosis or secondary progressive multiple sclerosis .", "sentence_id": 2}
+{"abstract_id": "25891548", "label": "methods", "text": "The study was conducted at @ sites in the United States and @ sites in Canada .", "sentence_id": 3}
+{"abstract_id": "25891548", "label": "methods", "text": "Patients were randomized @:@ to receive @ low-dose infusions of PDA-@ ( @ ( @ ) cells ) or placebo , given @ week apart .", "sentence_id": 4}
+{"abstract_id": "25891548", "label": "methods", "text": "After completing this cohort , subsequent patients received high-dose PDA-@ ( @ ( @ ) cells ) or placebo .", "sentence_id": 5}
+{"abstract_id": "25891548", "label": "methods", "text": "Monthly brain magnetic resonance imaging scans were performed .", "sentence_id": 6}
+{"abstract_id": "25891548", "label": "methods", "text": "The primary end point was ruling out the possibility of paradoxical worsening of MS disease activity .", "sentence_id": 7}
+{"abstract_id": "25891548", "label": "methods", "text": "This was monitored using Cutters rule ( @ new gadolinium lesions on @ consecutive scans ) by brain magnetic resonance imaging on a monthly basis for six months and also the frequency of multiple sclerosis relapse .", "sentence_id": 8}
+{"abstract_id": "25891548", "label": "results", "text": "Ten patients with relapsing-remitting multiple sclerosis and @ with secondary progressive multiple sclerosis were randomly assigned to treatment : @ to low-dose PDA-@ , @ to high-dose PDA-@ , and @ to placebo .", "sentence_id": 9}
+{"abstract_id": "25891548", "label": "results", "text": "No patient met Cutters rule .", "sentence_id": 10}
+{"abstract_id": "25891548", "label": "results", "text": "One patient receiving high-dose PDA-@ had an increase in T@ and gadolinium lesions and in Expanded Disability Status Scale score during a multiple sclerosis flare @ months after receiving PDA-@ .", "sentence_id": 11}
+{"abstract_id": "25891548", "label": "results", "text": "No other patient had an increase in Expanded Disability Status Scale score > @ , and most had stable or decreasing Expanded Disability Status Scale scores .", "sentence_id": 12}
+{"abstract_id": "25891548", "label": "results", "text": "With high-dose PDA-@ , @ patient experienced a grade @ anaphylactoid reaction and @ had grade @ superficial thrombophlebitis .", "sentence_id": 13}
+{"abstract_id": "25891548", "label": "results", "text": "Other adverse events were mild to moderate and included headache , fatigue , infusion site reactions , and urinary tract infection .", "sentence_id": 14}
+{"abstract_id": "25891548", "label": "conclusions", "text": "PDA-@ infusions were safe and well tolerated in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis patients .", "sentence_id": 15}
+{"abstract_id": "25891548", "label": "conclusions", "text": "No paradoxical worsening of lesion counts was noted with either dose .", "sentence_id": 16}
+{"abstract_id": "24409075", "label": "objective", "text": "To evaluate the efficacy and toxicity of nedaplatin ( NDP ) concurrent with radiotherapy in the treatment of locally advanced esophageal carcinoma .", "sentence_id": 0}
+{"abstract_id": "24409075", "label": "methods", "text": "Sixty-eight patients with locally advanced esophageal carcinoma were randomized into either a NDP group ( n = @ ) or a cisplatin ( DDP ) group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24409075", "label": "methods", "text": "The NDP group received NDP @-@ mg/m iv on day @ + leucovorin ( CF ) @ mg/m iv on days @-@ + @-fluorouracil ( @-FU ) @ mg/m iv on days @-@ .", "sentence_id": 2}
+{"abstract_id": "24409075", "label": "methods", "text": "The DDP group received DDP @ mg/m iv on days @-@ + CF @ mg/m on days @-@ + @-FU @ mg/m iv on days @-@ .", "sentence_id": 3}
+{"abstract_id": "24409075", "label": "methods", "text": "The treatment was repeated every @ wk in both groups .", "sentence_id": 4}
+{"abstract_id": "24409075", "label": "methods", "text": "Concurrent radiotherapy -LSB- @-@ Gy / ( @-@ f ) / ( @-@ wk ) -RSB- was given during chemotherapy .", "sentence_id": 5}
+{"abstract_id": "24409075", "label": "results", "text": "There was no significant difference in the short-term response rate between the NDP group and DDP group ( @ % vs @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24409075", "label": "results", "text": "Although the @ - and @-year survival rates were higher in the NDP group than in the DDP group ( @ % vs @ % , @ % vs @ % ) , the difference in the overall survival rate was not statistically significant between the two groups ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24409075", "label": "results", "text": "The incidences of nausea , vomiting and nephrotoxicity were significantly lower in the NDP group than in the DDP group ( @ % vs @ % , P = @ ; @ % vs @ % , P = @ ; @ % vs @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24409075", "label": "results", "text": "There was no significant difference in the incidence of myelosuppression , radiation-induced esophagitis or radiation-induced pneumonia between the two groups .", "sentence_id": 9}
+{"abstract_id": "24409075", "label": "conclusions", "text": "NDP-based concurrent chemoradiotherapy is effective and well-tolerated in patients with locally advanced esophageal carcinoma .", "sentence_id": 10}
+{"abstract_id": "24409075", "label": "conclusions", "text": "NDP-based regimen has comparable efficacy to DDP-based regimen but is associated with lower incidences of gastrointestinal and renal toxicity .", "sentence_id": 11}
+{"abstract_id": "25439340", "label": "objective", "text": "A growing body of studies consistently demonstrates that social responsiveness toward others is influenced by the neurohormone oxytocin .", "sentence_id": 0}
+{"abstract_id": "25439340", "label": "objective", "text": "However , the potential role of oxytocin for self-perception remains relatively unexplored .", "sentence_id": 1}
+{"abstract_id": "25439340", "label": "objective", "text": "Thus , we investigated whether oxytocin administration influences the self-attribution of positive and negative adjectives at the early , effortful stage of self-related information processing .", "sentence_id": 2}
+{"abstract_id": "25439340", "label": "methods", "text": "Sixty healthy male participants received either @I .", "sentence_id": 3}
+{"abstract_id": "25439340", "label": "methods", "text": "U. oxytocin or a placebo in a randomized double-blind study before completing a sorting task , in which they were instructed to co-classify , as fast as possible , positive and negative adjectives into either self or non-self categories .", "sentence_id": 4}
+{"abstract_id": "25439340", "label": "results", "text": "Oxytocin-treated participants reported stronger positive attitudes toward themselves compared to placebo .", "sentence_id": 5}
+{"abstract_id": "25439340", "label": "conclusions", "text": "The present findings demonstrate that oxytocin administration influences the early stage of self-related information processing and suggests that the oxytocinergic system might be involved in psychopathological conditions characterized by a negative representation of self .", "sentence_id": 6}
+{"abstract_id": "24225379", "label": "objective", "text": "Nonarteriitic anterior ischemic optic neuropathy ( NAION ) is a leading cause of sudden loss of vision , which particularly affects individuals older than @ years .", "sentence_id": 0}
+{"abstract_id": "24225379", "label": "objective", "text": "Up to now there is no treatment that is effective at reversing or limiting the course of this disease .", "sentence_id": 1}
+{"abstract_id": "24225379", "label": "objective", "text": "To study the short - and long-term effects of fluocortolone ( FC ) on the visual outcome of patients with acute NAION compared to standard treatment with pentoxifylline ( PFX ) .", "sentence_id": 2}
+{"abstract_id": "24225379", "label": "methods", "text": "A prospective , quasirandomized intervention trial was conducted involving @ patients with acute-onset NAION .", "sentence_id": 3}
+{"abstract_id": "24225379", "label": "methods", "text": "Patients in the comparison ( PFX ) group ( n = @ ) received PFX intravenously and per os for @ days and then per os for a further @ months , which is a standard treatment .", "sentence_id": 4}
+{"abstract_id": "24225379", "label": "methods", "text": "Patients in the intervention ( PFX + FC ) group ( n = @ ) received the standard treatment plus @ mg/kg FC for @ days , with a subsequent stepwise dose reduction over time .", "sentence_id": 5}
+{"abstract_id": "24225379", "label": "methods", "text": "As a primary outcome measure , the best corrected visual acuity ( BCVA ) was determined at the initial baseline consultation ( i.e. , before treatment ) , and at @ days and @ months after therapy onset .", "sentence_id": 6}
+{"abstract_id": "24225379", "label": "methods", "text": "Visual field ( VF ) was analyzed using standard automated perimetry at the initial baseline examination and at @ month after therapy onset .", "sentence_id": 7}
+{"abstract_id": "24225379", "label": "methods", "text": "Changes in BCVA and visual field in the PFX and PFX + FC groups were compared and analyzed statistically .", "sentence_id": 8}
+{"abstract_id": "24225379", "label": "results", "text": "Treatment with FC resulted in a significant improvement in BCVA .", "sentence_id": 9}
+{"abstract_id": "24225379", "label": "results", "text": "Patients receiving FC in acute NAION were more likely to experience improvement and less likely to have worsened visual acuity ( mean BCVA scores : at baseline , @ ; after @ days and @ months of treatment , @ and @ , respectively ) than PFX patients ( mean BCVA scores : at baseline , @ ; after @ days and @ months of treatment , @ and @ , respectively ; p < @ and @ ) .", "sentence_id": 10}
+{"abstract_id": "24225379", "label": "results", "text": "The beneficial effect was even more marked @ months after therapy onset .", "sentence_id": 11}
+{"abstract_id": "24225379", "label": "results", "text": "Remarkably , patients with a baseline BCVA score of > = @ profited significantly by FC treatment ( p < @ and @ ) , whereas those with a baseline BCVA score of < @ did not ( p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24225379", "label": "results", "text": "PFX did not improve BCVA .", "sentence_id": 13}
+{"abstract_id": "24225379", "label": "results", "text": "However , VF did not show any significant improvement due to FC therapy .", "sentence_id": 14}
+{"abstract_id": "24225379", "label": "conclusions", "text": "This is the first prospective randomized intervention trial that demonstrates the distinctive beneficial effects of FC in terms of the visual outcome of patients with NAION compared to standard treatment with only PFX .", "sentence_id": 15}
+{"abstract_id": "24225379", "label": "conclusions", "text": "FC significantly improves both short - and long-term visual acuity in patients with moderate BCVA impairment due to recent onset of NAION , while VF did not show any significant improvement ; however , PFX did neither enhance BCVA nor VF .", "sentence_id": 16}
+{"abstract_id": "24225379", "label": "conclusions", "text": "Administration of FC should be seriously considered for the treatment of NAION whenever there are no contraindications .", "sentence_id": 17}
+{"abstract_id": "24671237", "label": "objective", "text": "Currently , there is no consensus concerning the possible beneficial colonic and systemic effects of prebiotic-containing infant formula .", "sentence_id": 0}
+{"abstract_id": "24671237", "label": "objective", "text": "This study assesses whether the feeding of a galactooligosaccharides ( GOS ) - containing infant formula ( @ g/dl of GOS ) and the subsequent feeding of a GOS-containing follow-on formula ( @ g/dl of GOS ) have a prebiotic effect on intestinal microbiota that helps to decrease infections and allergy manifestations in healthy infants during the first year of life .", "sentence_id": 1}
+{"abstract_id": "24671237", "label": "methods", "text": "A multicentre , randomised , double-blind and placebo-controlled trial was carried out on @ healthy term infants enrolled before @ weeks of age and randomly assigned to a formula with or without GOS , until @ months of age .", "sentence_id": 2}
+{"abstract_id": "24671237", "label": "methods", "text": "The incidence of infections and allergy manifestations , the antibiotics prescribed and faecal characteristics were recorded up to @ months of age , while faecal samples were collected up to @ months for the measurement of secretory immunoglobulin A , short-chain fatty acids and microbiota .", "sentence_id": 3}
+{"abstract_id": "24671237", "label": "results", "text": "A prebiotic effect on the faecal analysis was observed at @ months of life .", "sentence_id": 4}
+{"abstract_id": "24671237", "label": "results", "text": "The GOS group showed a lower faecal pH ( P = @ ) , a lower decreasing trend in secretory immunoglobulin A ( P = @ ) , lower butyric acid concentration ( P = @ ) and an increase in Bifidobacterium counts ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24671237", "label": "results", "text": "Changes in faecal characteristics involved greater frequency ( P < @ ) and softer consistency ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24671237", "label": "results", "text": "The incidence of infections or allergic manifestations during the first year of life was similar in both groups , with no statistical differences ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24671237", "label": "conclusions", "text": "The feeding of GOS-containing infant formula produced a definite prebiotic effect consisting of changes in faecal composition and microbiota , and in faecal consistency and the frequency of defaecation .", "sentence_id": 8}
+{"abstract_id": "24671237", "label": "conclusions", "text": "No changes in the incidence of infection or allergic manifestation during the first year of life were observed .", "sentence_id": 9}
+{"abstract_id": "24754911", "label": "background", "text": "The Canola Oil Multicenter Intervention Trial ( COMIT ) was a randomized controlled crossover study designed to evaluate the effects of five diets that provided different oils and/or oil blends on cardiovascular disease ( CVD ) risk factors in individuals with abdominal obesity .", "sentence_id": 0}
+{"abstract_id": "24754911", "label": "background", "text": "The present objective is to report preliminary findings on plasma fatty acid profiles in volunteers with abdominal obesity , following the consumption of diets enriched with n-@ , n-@ and n-@ fatty acids .", "sentence_id": 1}
+{"abstract_id": "24754911", "label": "methods", "text": "COMIT was conducted at three clinical sites , Winnipeg , Manitoba , Canada , Qubec City , Qubec , Canada and University Park , Pennsylvania , United States .", "sentence_id": 2}
+{"abstract_id": "24754911", "label": "methods", "text": "Inclusion criteria were at least one of the followings : waist circumference ( @ cm for males and @ cm for females ) , and at least one other criterion : triglycerides @ mmol/L , high density lipoprotein cholesterol < @ mmol/L ( males ) or < @ mmol/L ( females ) , blood pressure @ mmHg ( systolic ) and/or @ mmHg ( diastolic ) , and glucose @ mmol/L .", "sentence_id": 3}
+{"abstract_id": "24754911", "label": "methods", "text": "Weight-maintaining diets that included shakes with one of the dietary oil blends were provided during each of the five @-day dietary phases .", "sentence_id": 4}
+{"abstract_id": "24754911", "label": "methods", "text": "Dietary phases were separated by four-week washout periods .", "sentence_id": 5}
+{"abstract_id": "24754911", "label": "methods", "text": "Treatment oils were canola oil , high oleic canola oil , high oleic canola oil enriched with docosahexaenoic acid ( DHA ) , flax oil and safflower oil blend , and corn oil and safflower oil blend .", "sentence_id": 6}
+{"abstract_id": "24754911", "label": "methods", "text": "A per protocol approach with a mixed model analysis was decided to be appropriate for data analysis .", "sentence_id": 7}
+{"abstract_id": "24754911", "label": "results", "text": "One hundred and seventy volunteers were randomized and @ completed the study with a dropout rate of @ % .", "sentence_id": 8}
+{"abstract_id": "24754911", "label": "results", "text": "The mean plasma total DHA concentrations , which were analyzed among all participants as a measure of adherence , increased by more than @ % in the DHA-enriched phase , compared to other phases , demonstrating excellent dietary adherence .", "sentence_id": 9}
+{"abstract_id": "24754911", "label": "conclusions", "text": "Recruitment and retention strategies were effective in achieving a sufficient number of participants who completed the study protocol to enable sufficient statistical power to resolve small differences in outcome measures .", "sentence_id": 10}
+{"abstract_id": "24754911", "label": "conclusions", "text": "It is expected that the study will generate important data thereby enhancing our understanding of the effects of n-@ , n-@ , and n-@ fatty acid-containing oils on CVD risks .", "sentence_id": 11}
+{"abstract_id": "24506142", "label": "objective", "text": "UK cancer guidelines recommend patients with colonic obstruction due to suspected malignancy be considered for stenting with a self-expanding metal stent ( SEMS ) .", "sentence_id": 0}
+{"abstract_id": "24506142", "label": "objective", "text": "Considerable variation in practice exists due to a lack of expertise , technical difficulties and other , as yet ill-defined features .", "sentence_id": 1}
+{"abstract_id": "24506142", "label": "objective", "text": "This retrospective multi-centre study aims to determine the outcome following colonic stenting for large bowel obstruction and identify factors associated with successful intervention .", "sentence_id": 2}
+{"abstract_id": "24506142", "label": "methods", "text": "A regional programme of colonic stenting for large bowel obstruction , in five UK centres from @ to @ was evaluated for outcome including technical and clinical success , survival , complications and reoperation .", "sentence_id": 3}
+{"abstract_id": "24506142", "label": "results", "text": "A SEMS was inserted in @ patients , including @ ( @ % ) for palliation and @ ( @ % ) as a bridge to surgery .", "sentence_id": 4}
+{"abstract_id": "24506142", "label": "results", "text": "Technical success was achieved in @ ( @ % ) patients , with @ ( @ % ) experiencing a complication or technical failure .", "sentence_id": 5}
+{"abstract_id": "24506142", "label": "results", "text": "Reoperation was required in @ ( @ % ) patients stented for palliation of colorectal cancer of whom @ ( @ % ) subsequently required a colostomy .", "sentence_id": 6}
+{"abstract_id": "24506142", "label": "results", "text": "A one-stage primary anastomosis was achieved in @ ( @ % ) of the @ patients undergoing stenting as a bridge to resection .", "sentence_id": 7}
+{"abstract_id": "24506142", "label": "results", "text": "Technical success did not vary by indication or site of obstruction ( P = @ ) but was higher for operators who had performed more than @ procedures ( OR @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24506142", "label": "results", "text": "ASA grade @ predicted a worse clinical outcome ( OR @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24506142", "label": "results", "text": "The through-the-scope ( TTS ) endoscopy technique was more successful than radiological placement alone ( @ % vs @ % , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24506142", "label": "conclusions", "text": "Experienced operators using a TTS technique achieved a better outcome for the emergency management of large bowel obstruction .", "sentence_id": 11}
+{"abstract_id": "24506142", "label": "conclusions", "text": "Older , sicker patients and those with extracolonic and benign strictures fared less well .", "sentence_id": 12}
+{"abstract_id": "24907703", "label": "objective", "text": "The guided outcomes in learned efficiency ( GOLE ) model emphasizes the use of evidence-based resources to understand the diagnosis , treatment , follow-up , and prevention of disease .", "sentence_id": 0}
+{"abstract_id": "24907703", "label": "objective", "text": "We seek to determine whether presentations created using the GOLE model are superior to an unstructured approach in achieving Accreditation Council for Graduate Medical Education ( ACGME ) Core Competencies .", "sentence_id": 1}
+{"abstract_id": "24907703", "label": "methods", "text": "Consenting medical students were randomized to GOLE or control groups to individually research a self-selected clinical topic .", "sentence_id": 2}
+{"abstract_id": "24907703", "label": "methods", "text": "A validated survey instrument was used prepresentation and postpresentation to assess perceived improvement in knowledge .", "sentence_id": 3}
+{"abstract_id": "24907703", "label": "methods", "text": "Subjects completed self-evaluations at enrollment and after presentation of their chosen clinical topic .", "sentence_id": 4}
+{"abstract_id": "24907703", "label": "methods", "text": "Other students , residents , and a faculty member also completed evaluations after each student presentation .", "sentence_id": 5}
+{"abstract_id": "24907703", "label": "methods", "text": "Standard statistical methods ( analysis of variance , @-tailed t test ) were used to determine if a statistically significant difference existed between intervention and control groups .", "sentence_id": 6}
+{"abstract_id": "24907703", "label": "results", "text": "Self-assessments were similar in the GOLE and control groups .", "sentence_id": 7}
+{"abstract_id": "24907703", "label": "results", "text": "Externally perceived presentation scores were greater in the GOLE group ( ACGME global P < @ , presentation global P = @ ) , which demonstrated a significant improvement in @ core competencies .", "sentence_id": 8}
+{"abstract_id": "24907703", "label": "results", "text": "Time spent preparing the presentation and resources utilized did not differ between groups .", "sentence_id": 9}
+{"abstract_id": "24907703", "label": "conclusions", "text": "The presentations prepared using the GOLE model were rated higher by observers than those prepared using traditional techniques .", "sentence_id": 10}
+{"abstract_id": "25311606", "label": "objective", "text": "The neighborhoods in which children live , play , and eat provide an environmental context that may influence obesity risk and ameliorate or exacerbate health disparities .", "sentence_id": 0}
+{"abstract_id": "25311606", "label": "objective", "text": "The current study examines whether neighborhood characteristics predict obesity in a prospective cohort of girls .", "sentence_id": 1}
+{"abstract_id": "25311606", "label": "methods", "text": "Participants were @ girls ( aged @-@ years at baseline ) , a subset from the Cohort Study of Young Girls ' Nutrition , Environment , and Transitions .", "sentence_id": 2}
+{"abstract_id": "25311606", "label": "methods", "text": "Trained observers completed street audits within a @-mile radius around each girl 's residence .", "sentence_id": 3}
+{"abstract_id": "25311606", "label": "methods", "text": "Four scales ( food and service retail , recreation , walkability , and physical disorder ) were created from @ observed neighborhood features .", "sentence_id": 4}
+{"abstract_id": "25311606", "label": "methods", "text": "BMI was calculated from clinically measured height and weight .", "sentence_id": 5}
+{"abstract_id": "25311606", "label": "methods", "text": "Obesity was defined as BMI-for-age @ % .", "sentence_id": 6}
+{"abstract_id": "25311606", "label": "methods", "text": "Logistic regression models using generalized estimating equations were used to examine neighborhood influences on obesity risk over @ years of follow-up , controlling for race/ethnicity , pubertal status , and baseline BMI .", "sentence_id": 7}
+{"abstract_id": "25311606", "label": "methods", "text": "Fully adjusted models also controlled for household income , parent education , and a census tract measure of neighborhood socioeconomic status .", "sentence_id": 8}
+{"abstract_id": "25311606", "label": "results", "text": "A @-SD increase on the food and service retail scale was associated with a @ ( @ % confidence interval , @ to @ ; P < @ ) increased odds of being obese .", "sentence_id": 9}
+{"abstract_id": "25311606", "label": "results", "text": "A @-SD increase in physical disorder was associated with a @ ( @ % confidence interval , @ to @ ; P = @ ) increased odds of being obese .", "sentence_id": 10}
+{"abstract_id": "25311606", "label": "results", "text": "Other neighborhood scales were not associated with risk for obesity .", "sentence_id": 11}
+{"abstract_id": "25311606", "label": "conclusions", "text": "Neighborhood food and retail environment and physical disorder around a girl 's home predict risk for obesity across the transition from late childhood to adolescence .", "sentence_id": 12}
+{"abstract_id": "25321869", "label": "objective", "text": "Cervical total disc replacement ( CTDR ) was developed to treat cervical spondylosis , while preserving motion .", "sentence_id": 0}
+{"abstract_id": "25321869", "label": "objective", "text": "While anterior cervical discectomy and fusion ( ACDF ) has been the standard of care for @-level disease , a randomized clinical trial ( RCT ) suggested similar outcomes .", "sentence_id": 1}
+{"abstract_id": "25321869", "label": "objective", "text": "Cost-effectiveness of this intervention has never been elucidated .", "sentence_id": 2}
+{"abstract_id": "25321869", "label": "objective", "text": "To determine the cost-effectiveness of CTDR compared with ACDF .", "sentence_id": 3}
+{"abstract_id": "25321869", "label": "methods", "text": "Data were derived from an RCT that followed up @ patients over @ months .", "sentence_id": 4}
+{"abstract_id": "25321869", "label": "methods", "text": "The original RCT consisted of multi-institutional data including private and academic institutions .", "sentence_id": 5}
+{"abstract_id": "25321869", "label": "methods", "text": "Using linear regression for the current study , health states were constructed based on the stratification of the Neck Disability Index and a visual analog scale .", "sentence_id": 6}
+{"abstract_id": "25321869", "label": "methods", "text": "Data from the @-item Short-Form Health Survey questionnaires were transformed into utilities values using the SF-@D mapping algorithm .", "sentence_id": 7}
+{"abstract_id": "25321869", "label": "methods", "text": "Costs were calculated by extracting Diagnosis-Related Group codes from institutional billing data and then applying @ Medicare reimbursement rates .", "sentence_id": 8}
+{"abstract_id": "25321869", "label": "methods", "text": "The costs of complications and return-to-work data were also calculated .", "sentence_id": 9}
+{"abstract_id": "25321869", "label": "methods", "text": "A Markov model was built to evaluate quality-adjusted life-years ( QALYs ) for both treatment groups .", "sentence_id": 10}
+{"abstract_id": "25321869", "label": "methods", "text": "The model adopted a third-party payer perspective and applied a @ % annual discount rate .", "sentence_id": 11}
+{"abstract_id": "25321869", "label": "methods", "text": "Patients included in the original RCT had to be diagnosed as having radiculopathy or myeloradiculopathy at @ contiguous levels from C@-C@ that was unresponsive to conservative treatment for at least @ weeks or demonstrated progressive symptoms .", "sentence_id": 12}
+{"abstract_id": "25321869", "label": "methods", "text": "Incremental cost-effectiveness ratio of CTDR compared with ACDF .", "sentence_id": 13}
+{"abstract_id": "25321869", "label": "results", "text": "A strong correlation ( R@ = @ ; P < @ ) was found by projecting a visual analog scale onto the Neck Disability Index .", "sentence_id": 14}
+{"abstract_id": "25321869", "label": "results", "text": "Cervical total disc replacement had an average of @ QALYs after @ months compared with @ QALYs for ACDF recipients .", "sentence_id": 15}
+{"abstract_id": "25321869", "label": "results", "text": "Cervical total disc replacement was associated with $ @ greater average cost .", "sentence_id": 16}
+{"abstract_id": "25321869", "label": "results", "text": "The incremental cost-effectiveness ratio of CTDR compared with ACDF was $ @,@ per QALY at @ years .", "sentence_id": 17}
+{"abstract_id": "25321869", "label": "results", "text": "Despite varying input parameters in the sensitivity analysis , the incremental cost-effectiveness ratio value stays below the threshold of $ @,@ per QALY in most scenarios ( range , - $ @,@ to $ @,@ per QALY ) .", "sentence_id": 18}
+{"abstract_id": "25321869", "label": "conclusions", "text": "The incremental cost-effectiveness ratio of CTDR compared with traditional ACDF is lower than the commonly accepted threshold of $ @,@ per QALY .", "sentence_id": 19}
+{"abstract_id": "25321869", "label": "conclusions", "text": "This remains true with varying input parameters in a robust sensitivity analysis , reaffirming the stability of the model and the sustainability of this intervention .", "sentence_id": 20}
+{"abstract_id": "24601174", "label": "background", "text": "Dipeptidyl peptidase-@ ( DPP-@ ) inhibitors are a new class of antihyperglycemic drugs that block degradation ofincretin hormones .", "sentence_id": 0}
+{"abstract_id": "24601174", "label": "objective", "text": "To assess the effects oftreatment with DPP-@ inhibitors on glucoregulation and body weight in obese patients with type @ diabetes mellitus .", "sentence_id": 1}
+{"abstract_id": "24601174", "label": "methods", "text": "The study included @ females and @ males with type @ diabetes ( n = @ ) , BMI = @ + / - @,@ kg/m@ , mean age @ + / - @,@ years .", "sentence_id": 2}
+{"abstract_id": "24601174", "label": "methods", "text": "The patients have been thoroughly evaluated before treatment , and @ months after treatment with DPP-@ inhibitor ( sitagliptin ) in combination with metformin .", "sentence_id": 3}
+{"abstract_id": "24601174", "label": "results", "text": "After @ months of treatment with DPP-@ inhibitors in combination with metformin HbAlc ( -@,@ % ) .", "sentence_id": 4}
+{"abstract_id": "24601174", "label": "results", "text": ", FBG ( -@ mmol/L ) and PBG ( -@ mmol/L ) significantly reduced ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24601174", "label": "results", "text": "Mean body weight also significantly reduced ( -@ % ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24601174", "label": "results", "text": "Reduction of mean fasting insulin was @ mIU/L or @ % ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24601174", "label": "results", "text": "Mean HOMA-IR change was -@ ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24601174", "label": "results", "text": "Also there was significant decreasing of systolic blood pressure ( p = @ ) , cholesterol ( p = @ ) , triglycerides ( p = @ ) , LDL ( p = @ ) and increasing of HDL ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24601174", "label": "results", "text": "Hypoglycaemia was not registered in any of the patients .", "sentence_id": 10}
+{"abstract_id": "24601174", "label": "conclusions", "text": "These results show that in obese patients with type @ diabetes , DPP-@ inhibitors treatment in combination with metformin was associated with improvements in glycaemic control , and a reduction in body weight .", "sentence_id": 11}
+{"abstract_id": "24742970", "label": "background", "text": "This is a report of a clinical trial on the therapeutic efficacy and safety of combined aliskiren and losartan ( an angiotensin II receptor blocker ( ARB ) ) versus aliskiren alone and ARB alone in non-diabetic chronic kidney disease ( CKD ) over a @-year period .", "sentence_id": 0}
+{"abstract_id": "24742970", "label": "methods", "text": "This was a randomised trial in @ patients with non-diabetic CKD comparing aliskiren ( @ mg/day ) ( n = @ ) versus losartan ( @ mg/day ) ( n = @ ) and the third group aliskiren ( @ mg/day ) combined with losartan ( @ mg/day ) ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24742970", "label": "methods", "text": "The trial utilised primary renal end points of eGFR < @ ml/min or end-stage renal failure .", "sentence_id": 2}
+{"abstract_id": "24742970", "label": "results", "text": "All three groups had significant reduction of proteinuria ( p < @ for all ) .", "sentence_id": 3}
+{"abstract_id": "24742970", "label": "results", "text": "The changes in eGFR , total urinary protein from baseline to each year were not significantly different between the three therapeutic groups .", "sentence_id": 4}
+{"abstract_id": "24742970", "label": "conclusions", "text": "This study in non-diabetic CKD patients showed that combination therapy with aliskiren and ARB was as efficacious as aliskiren alone and ARB alone .", "sentence_id": 5}
+{"abstract_id": "24742970", "label": "conclusions", "text": "There was one patient who developed a non-fatal stroke in the combined aliskiren and ARB group while the other two groups had none .", "sentence_id": 6}
+{"abstract_id": "25117466", "label": "objective", "text": "Very low density lipoprotein triglyceride ( VLDL-TG ) and free fatty acids ( FFA ) constitute a substantial proportion of human energy supply both at rest and during exercise .", "sentence_id": 0}
+{"abstract_id": "25117466", "label": "objective", "text": "Exercise acutely decreases VLDL-TG concentration , and VLDL-TG clearance is increased after an exercise bout .", "sentence_id": 1}
+{"abstract_id": "25117466", "label": "objective", "text": "However , the effects of long-term training are not clear .", "sentence_id": 2}
+{"abstract_id": "25117466", "label": "methods", "text": "The aim was to investigate long-term effects of training by direct assessments of VLDL-TG and palmitate kinetics and oxidation in healthy lean men ( n = @ ) at rest , before and after a @-week training program , compared with a non-training control group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25117466", "label": "methods", "text": "VLDL-TG kinetics were assessed by a primed constant infusion of -LSB- @-@C -RSB- VLDL-TG , and VLDL-TG oxidation by specific activity ( @CO@ ) in expired air .", "sentence_id": 4}
+{"abstract_id": "25117466", "label": "methods", "text": "The metabolic study days were placed @-@h after the last exercise bout .", "sentence_id": 5}
+{"abstract_id": "25117466", "label": "results", "text": "Palmitate kinetics and oxidation were assessed by a @h constant infusion of -LSB- @,@ - ( @ ) H -RSB- palmitate .", "sentence_id": 6}
+{"abstract_id": "25117466", "label": "results", "text": "In the training group ( n = @ ) , maximal oxygen uptake increased significantly by @ % ( P < @ ) , and the insulin sensitivity ( assessed by the hyperinsulinemic-euglycemic clamp ) improved significantly ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25117466", "label": "results", "text": "Despite these metabolic improvements , no changes were observed in VLDL-TG secretion , clearance , or oxidation or in palmitate kinetics .", "sentence_id": 8}
+{"abstract_id": "25117466", "label": "conclusions", "text": "We conclude that @ weeks of exercise training did not induce changes in VLDL-TG and palmitate kinetics in healthy lean men .", "sentence_id": 9}
+{"abstract_id": "25229957", "label": "objective", "text": "To explore the effect of structural family therapy ( SFT ) , which refers to the application of the theory and technology of SFT for improving the internal family environment of pediatric patients through reorganization of the family roles , tasks , and boundaries , on the family structure and function in children with hematological tumors .", "sentence_id": 0}
+{"abstract_id": "25229957", "label": "methods", "text": "Forty children with hematological tumors were randomly divided into SFT and control groups ( n = @ each ) .", "sentence_id": 1}
+{"abstract_id": "25229957", "label": "methods", "text": "The control group received conventional chemotherapy .", "sentence_id": 2}
+{"abstract_id": "25229957", "label": "methods", "text": "The SFT group received SFT by a trained therapist in addition to conventional chemotherapy ; the family of each patient received SFT four times ( once every two weeks ) .", "sentence_id": 3}
+{"abstract_id": "25229957", "label": "methods", "text": "Both groups were assessed by the Family Assessment Device ( FAD ) and Family Environment Scale-Chinese Version ( FES-CV ) on admission and one month after the end of SFT .", "sentence_id": 4}
+{"abstract_id": "25229957", "label": "results", "text": "After treatment , the SFT group showed significant decreases in all factor scores of FAD ( P < @ ) ; the SFT group had significantly lower scores of problem solving , communication , roles , affective involvement , behavior control , and general functioning than the control group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25229957", "label": "results", "text": "In addition , the SFT group had significantly increased FES-CV scores of cohesion , emotional expression , intellectual-cultural orientation , and active-recreational orientation and a significantly decreased score of conflict after treatment ( P < @ ) , and the SFT group was significantly superior to the control group in terms of these items ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25229957", "label": "conclusions", "text": "SFT could promote beneficial family changes in children with hematological tumors by improving the family function and internal environment , which would increase the long-term chemotherapy compliance of these children and their parents .", "sentence_id": 7}
+{"abstract_id": "24720741", "label": "objective", "text": "The aim of this study was to assess pain associated with subcutaneous injection into the abdomen and thigh of different combinations of injection speeds and volumes .", "sentence_id": 0}
+{"abstract_id": "24720741", "label": "methods", "text": "The study was a single-centre , one-visit , double-blinded , randomized controlled trial in @ adults with type @ or type @ diabetes receiving daily injections of insulin or glucagon-like peptide-@ ( GLP-@ ) agonists .", "sentence_id": 1}
+{"abstract_id": "24720741", "label": "methods", "text": "Participants received @ subcutaneous injections ( @ in abdomen , @ in thigh ) of saline at different injection speeds ( @ , @ and @ l/s ) , with different volumes ( @ , @ , @ and @ l ) , and two needle insertions without any injection .", "sentence_id": 2}
+{"abstract_id": "24720741", "label": "methods", "text": "Pain was evaluated on a @-mm visual analogue scale ( VAS ) ( @ mm no pain , @ mm worst pain ) and on a yes/no scale for pain acceptability .", "sentence_id": 3}
+{"abstract_id": "24720741", "label": "results", "text": "Injection speed had no impact on injection pain ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24720741", "label": "results", "text": "Injection of larger volumes caused significantly more pain -LSB- VAS least square mean differences @ vs. @ l , @ @ mm ( @ % confidence interval - CI ; @-@ @ ; p < @ ) ; @ vs. @ l , @ mm ( @-@ @ ; p < @ ) ; @ vs. @ l , @ mm ( @-@ @ ; p = @ ) and @ vs. @ l , @ mm ( @-@ @ ; p = @ ) -RSB- .", "sentence_id": 5}
+{"abstract_id": "24720741", "label": "results", "text": "Significantly more pain occurred in the thigh versus the abdomen -LSB- @ mm ( @-@ @ ; p < @ ) -RSB- .", "sentence_id": 6}
+{"abstract_id": "24720741", "label": "conclusions", "text": "Injection speed had no effect on injection pain , whereas higher injection volumes caused more pain .", "sentence_id": 7}
+{"abstract_id": "24720741", "label": "conclusions", "text": "The results of this study may be of value for guiding patients to use the appropriate injection site and technique to reduce their injection pain .", "sentence_id": 8}
+{"abstract_id": "24720741", "label": "conclusions", "text": "Furthermore , these findings may have important implications for the development of new injection devices and drug formulations for clinical practice .", "sentence_id": 9}
+{"abstract_id": "26258318", "label": "objective", "text": "To compare with antibiotics with methicillin-resistant microbial coverage in a prospective fashion .", "sentence_id": 0}
+{"abstract_id": "26258318", "label": "background", "text": "Current antibiotic prophylaxis for vascular procedures includes a first generation cephalosporin .", "sentence_id": 1}
+{"abstract_id": "26258318", "label": "background", "text": "No changes in recommendations have occurred despite changes in reports of incidence of MRSA related surgical site infections .", "sentence_id": 2}
+{"abstract_id": "26258318", "label": "background", "text": "Does supplemental anti-MRSA prophylactic coverage provide a significant reduction in Gram-positive or MRSA infections ?", "sentence_id": 3}
+{"abstract_id": "26258318", "label": "methods", "text": "Single center prospective double blinded randomized study of patients undergoing lower extremity vascular procedures from @ to @ .", "sentence_id": 4}
+{"abstract_id": "26258318", "label": "methods", "text": "One hundred seventy-eight ( @ ) patients were evaluated at @ days for surgical site infection .", "sentence_id": 5}
+{"abstract_id": "26258318", "label": "methods", "text": "Infections were categorized as early infections less than @ days of the index procedure and late after @ days .", "sentence_id": 6}
+{"abstract_id": "26258318", "label": "results", "text": "Early vascular surgical site infection occurred in @ ( @ % ) of patients in the Vancomycin arm , and @ ( @ % ) in the Daptomycin arm ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26258318", "label": "results", "text": "Gram-positive related infections and MRSA infections occurred in @ ( @ % ) / @ ( @ % ) of Vancomycin patients and @ ( @ % ) / @ ( @ % ) of Daptomycin patients , respectively ( P < @ and P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26258318", "label": "results", "text": "Readmissions related to surgical site infections occurred in @ ( @ % ) in the Vancomycin group and @ ( @ % ) in the Daptomycin group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26258318", "label": "results", "text": "Patients undergoing operative exploration occurred in @ ( @ % ) in the Vancomycin group and @ ( @ % ) of the Daptomycin group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26258318", "label": "results", "text": "Late infections were reported in @ patients , @ of which were in the combined Daptomycin group .", "sentence_id": 11}
+{"abstract_id": "26258318", "label": "results", "text": "Median hospital charges related to readmissions due to a surgical site infection was $ @,@ in the combination Vancomycin arm and $ @,@ in the combination Daptomycin group ; however , no statistical significance was appreciated ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "26258318", "label": "conclusions", "text": "Vancomycin supplemental prophylaxis seems to reduce the incidence of Gram-positive infection compared with adding supplemental Daptomycin prophylaxis .", "sentence_id": 13}
+{"abstract_id": "26258318", "label": "conclusions", "text": "The Incidence of MRSA-related surgical site infections is low with the addition of either anti-MRSA agents compared with historical incidence of MRSA-related infection .", "sentence_id": 14}
+{"abstract_id": "24758510", "label": "background", "text": "The management of patients with angiographically intermediate coronary lesions is a major clinical issue .", "sentence_id": 0}
+{"abstract_id": "24758510", "label": "background", "text": "Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging .", "sentence_id": 1}
+{"abstract_id": "24758510", "label": "background", "text": "Both techniques may be applied to guide management in case of angiographically intermediate coronary lesions .", "sentence_id": 2}
+{"abstract_id": "24758510", "label": "background", "text": "Moreover , these techniques may be used to optimize the result of percutaneous coronary intervention .", "sentence_id": 3}
+{"abstract_id": "24758510", "label": "background", "text": "We aim to compare the clinical and economic impact of fractional flow reserve versus optical coherence tomography guidance in patients with angiographically intermediate coronary lesions .", "sentence_id": 4}
+{"abstract_id": "24758510", "label": "methods", "text": "Patients with at least one angiographically intermediate coronary lesion will be randomized ( ratio @:@ ) to fractional flow reserve or optical coherence tomography guidance .", "sentence_id": 5}
+{"abstract_id": "24758510", "label": "methods", "text": "In the fractional flow reserve arm , percutaneous coronary intervention will be performed if fractional flow reserve value is @ , and will be conducted with the aim of achieving a post-percutaneous coronary intervention fractional flow reserve target value of @ .", "sentence_id": 6}
+{"abstract_id": "24758510", "label": "methods", "text": "In the optical coherence tomography arm , percutaneous coronary intervention will be performed if percentage of area stenosis ( AS % ) is @ % or @ to @ % with minimal lumen area < @ mm@ , or if a major plaque ulceration is detected .", "sentence_id": 7}
+{"abstract_id": "24758510", "label": "methods", "text": "In case of percutaneous coronary intervention , optical coherence tomography will guide the procedure in order to minimize under-expansion , malapposition , and edge dissections.Cost load and clinical outcome will be prospectively assessed at one and thirteen months .", "sentence_id": 8}
+{"abstract_id": "24758510", "label": "methods", "text": "The assessed clinical outcome measures will be : major cardiovascular events and occurrence of significant angina defined as a Seattle Angina Questionnaire score < @ in the angina frequency scale .", "sentence_id": 9}
+{"abstract_id": "24758510", "label": "conclusions", "text": "The FORZA trial will provide useful guidance for the management of patients with coronary artery disease by prospectively assessing the use of two techniques representing the gold standard for functional and anatomical definition of coronary plaques .", "sentence_id": 10}
+{"abstract_id": "25474278", "label": "objective", "text": "The aim of this study was to evaluate the prognostic value of MSI-H and p@ overexpression in metastatic colorectal cancer ( mCRC ) treated with oxaliplatin and fluoropyrimidine-based first line chemotherapy .", "sentence_id": 0}
+{"abstract_id": "25474278", "label": "methods", "text": "Tumour samples were retrospectively obtained from @ patients from a prospective randomised phase III trial of the AIO colorectal study group , comparing CAPOX and FUFOX in mCRC .", "sentence_id": 1}
+{"abstract_id": "25474278", "label": "methods", "text": "Immunohistochemistry of p@ and MMR proteins as well as microsatellite analysis were performed .", "sentence_id": 2}
+{"abstract_id": "25474278", "label": "results", "text": "The incidence of MSI-H and p@ overexpression was @ % and @ % , respectively .", "sentence_id": 3}
+{"abstract_id": "25474278", "label": "results", "text": "MSI-H status was not correlated with ORR , PFS and OS .", "sentence_id": 4}
+{"abstract_id": "25474278", "label": "results", "text": "We observed a trend to lower DCR for MSI-H tumours ( @ % vs. @ % , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25474278", "label": "results", "text": "p@ overexpression was not correlated with DCR , ORR and PFS .", "sentence_id": 6}
+{"abstract_id": "25474278", "label": "results", "text": "The median OS of patients with tumors with p@ overexpression was significantly longer compared to tumors withhout p@ overexpression ( @ vs. @ months ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25474278", "label": "results", "text": "The post-progression survival ( PPS ) of p@-positive patients undergoing @nd and/or @rd line chemotherapy with irinotecan and/or cetuximab was significantly longer compared to p@-negative patients .", "sentence_id": 8}
+{"abstract_id": "25474278", "label": "conclusions", "text": "MSI-H tumours tend to have lower disease control rates when treated with an oxaliplatin/fluoropyrmidin combination .", "sentence_id": 9}
+{"abstract_id": "25474278", "label": "conclusions", "text": "mCRC patients with p@ overexpression undergoing an irinotecan containing second - or third-line chemotherapy after oxaliplatin failure have a significantly longer post-progression survival compared to patients without p@ overexpression .", "sentence_id": 10}
+{"abstract_id": "25474278", "label": "conclusions", "text": "To validate the clinical impact of p@ in patients with mCRC treated with irinotecan - and/or cetuximab further studies are needed .", "sentence_id": 11}
+{"abstract_id": "24629635", "label": "background", "text": "New drug regimens of greater efficacy and shorter duration are needed for tuberculosis ( TB ) treatment .", "sentence_id": 0}
+{"abstract_id": "24629635", "label": "background", "text": "The identification of accurate , quantitative , non-culture based markers of treatment response would improve the efficiency of Phase @ TB drug testing .", "sentence_id": 1}
+{"abstract_id": "24629635", "label": "methods", "text": "In an unbiased biomarker discovery approach , we applied a highly multiplexed , aptamer-based , proteomic technology to analyze serum samples collected at baseline and after @ weeks of treatment from @ patients with pulmonary TB from Kampala , Uganda enrolled in a Centers for Disease Control and Prevention ( CDC ) TB Trials Consortium Phase @B treatment trial .", "sentence_id": 2}
+{"abstract_id": "24629635", "label": "results", "text": "We identified protein expression differences associated with @-week culture status , including Coagulation Factor V , SAA , XPNPEP@ , PSME@ , IL-@ R , HSP@ , Galectin-@ , @-Antiplasmin , ECM@ , YES , IGFBP-@ , CATZ , BGN , LYNB , and IL-@ .", "sentence_id": 3}
+{"abstract_id": "24629635", "label": "results", "text": "Markers noted to have differential changes between responders and slow-responders included nectin-like protein @ , EphA@ ( Ephrin type-A receptor @ ) , gp@ , CNDP@ , TGF-b RIII , MRC@ , ADAM@ , and CDON .", "sentence_id": 4}
+{"abstract_id": "24629635", "label": "results", "text": "A logistic regression model combining markers associated with @-week culture status revealed an ROC curve with AUC = @ , sensitivity = @ and specificity = @ .", "sentence_id": 5}
+{"abstract_id": "24629635", "label": "results", "text": "Additional markers showed differential changes between responders and slow-responders ( nectin-like protein ) , or correlated with time-to-culture-conversion ( KLRK@ ) .", "sentence_id": 6}
+{"abstract_id": "24629635", "label": "conclusions", "text": "Serum proteins involved in the coagulation cascade , neutrophil activity , immunity , inflammation , and tissue remodeling were found to be associated with TB treatment response .", "sentence_id": 7}
+{"abstract_id": "24629635", "label": "conclusions", "text": "A quantitative , non-culture based , five-marker signature predictive of @-week culture status was identified in this pilot study .", "sentence_id": 8}
+{"abstract_id": "24481333", "label": "objective", "text": "The ability of polymer-modified coils to promote stable aneurysm occlusion after endovascular treatment is not well-documented .", "sentence_id": 0}
+{"abstract_id": "24481333", "label": "objective", "text": "Angiographic aneurysm recurrence is widely used as a surrogate for treatment failure , but studies documenting the correlation of angiographic recurrence with clinical failure are limited .", "sentence_id": 1}
+{"abstract_id": "24481333", "label": "objective", "text": "This trial compares the effectiveness of Matrix ( @ ) polyglycolic/polylactic acid biopolymer-modified coils with bare metal coils and correlates the angiographic findings with clinical failure ( ie , target aneurysm recurrence ) , a composite end point that includes any incident of posttreatment aneurysm rupture , retreatment , or unexplained death .", "sentence_id": 2}
+{"abstract_id": "24481333", "label": "methods", "text": "This was a multicenter randomized noninferiority trial with blinded end point adjudication .", "sentence_id": 3}
+{"abstract_id": "24481333", "label": "methods", "text": "We enrolled @ patients , divided between Matrix ( @ ) and bare metal coil groups .", "sentence_id": 4}
+{"abstract_id": "24481333", "label": "methods", "text": "The primary outcome was target aneurysm recurrence at @ @ months .", "sentence_id": 5}
+{"abstract_id": "24481333", "label": "results", "text": "At @ days , at least @ target aneurysm recurrence event had occurred in @ % of patients treated with bare metal coils and @ % of Matrix ( @ ) ( P = @ , log-rank test ) patients ; @ % of target aneurysm recurrence events were re-interventions for aneurysms that had not bled after treatment , and @ % of target aneurysm recurrence events resulted from hemorrhage or rehemorrhage , with or without retreatment .", "sentence_id": 6}
+{"abstract_id": "24481333", "label": "results", "text": "Symptomatic re-intervention occurred in only @ ( @ % ) patients .", "sentence_id": 7}
+{"abstract_id": "24481333", "label": "results", "text": "At @ days , @ % of patients with unruptured aneurysms and @ % of those with ruptured aneurysms were independent ( mRS @ ) .", "sentence_id": 8}
+{"abstract_id": "24481333", "label": "results", "text": "Target aneurysm recurrence was associated with incomplete initial angiographic aneurysm obliteration , presentation with rupture , and a larger aneurysmal dome and neck size .", "sentence_id": 9}
+{"abstract_id": "24481333", "label": "conclusions", "text": "Tested Matrix ( @ ) coils were not inferior to bare metal coils .", "sentence_id": 10}
+{"abstract_id": "24481333", "label": "conclusions", "text": "Endovascular coiling of intracranial aneurysms was safe , and the rate of technical success was high .", "sentence_id": 11}
+{"abstract_id": "24481333", "label": "conclusions", "text": "Target aneurysm recurrence is a promising clinical outcome measure that correlates well with established angiographic measurements .", "sentence_id": 12}
+{"abstract_id": "25140032", "label": "background", "text": "Regular aerobic exercise in patients with cystic fibrosis ( CF ) improves aerobic conditioning and delays disease progression , resulting in better quality of life .", "sentence_id": 0}
+{"abstract_id": "25140032", "label": "background", "text": "The purpose of this study was to evaluate the effect of an aerobic exercise program based on verbal and written guidelines on maximum exercise capacity using a cardiopulmonary exercise test , quality of life , and the self-reported aerobic exercise practice of children and adolescents with CF.", "sentence_id": 1}
+{"abstract_id": "25140032", "label": "methods", "text": "This randomized controlled trial followed guidelines for physical exercise in a CF center .", "sentence_id": 2}
+{"abstract_id": "25140032", "label": "methods", "text": "Subjects were assigned to @ groups : intervention ( group @ ) , with @ subjects ; and control ( group @ ) , also with @ subjects .", "sentence_id": 3}
+{"abstract_id": "25140032", "label": "methods", "text": "Data were collected from October @ to October @ , and the study population comprised @-@-y-old children and adolescents with CF. The intervention consisted of handing out a manual with guidelines for aerobic physical exercises and reinforcing recommendations in telephone calls every @ weeks .", "sentence_id": 4}
+{"abstract_id": "25140032", "label": "results", "text": "Thirty-four subjects were included in the study , @ of whom were boys ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25140032", "label": "results", "text": "The groups were similar at baseline .", "sentence_id": 6}
+{"abstract_id": "25140032", "label": "results", "text": "In group @ , @ subjects ( @ % ) reported practicing physical exercises regularly .", "sentence_id": 7}
+{"abstract_id": "25140032", "label": "results", "text": "The mean age was @ @ y , the mean percent-of-predicted FEV@ was @ @ % , and the mean peak oxygen uptake ( VO@ ) relative to body mass was @ @ mL/kg/min .", "sentence_id": 8}
+{"abstract_id": "25140032", "label": "results", "text": "In group @ , @ subjects ( @ % ) reported practicing physical exercises regularly .", "sentence_id": 9}
+{"abstract_id": "25140032", "label": "results", "text": "The mean age was @ @ y , the mean percent-of-predicted FEV@ was @ @ % , and the mean peak VO@ was @ @ mL/kg/min .", "sentence_id": 10}
+{"abstract_id": "25140032", "label": "results", "text": "In group @ , there was a significant increase in physical exercise practice as reported by subjects after @ months of intervention compared with group @ ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25140032", "label": "results", "text": "No statistically significant differences were found for the other variables .", "sentence_id": 12}
+{"abstract_id": "25140032", "label": "conclusions", "text": "Verbal and written guidelines for aerobic exercise , together with supervision over the telephone , had a positive impact on the self-reported regular physical exercise practice of children and adolescents .", "sentence_id": 13}
+{"abstract_id": "25140032", "label": "conclusions", "text": "However , no improvement was found in lung function and maximum exercise capacity or domains of the quality of life questionnaire .", "sentence_id": 14}
+{"abstract_id": "25915712", "label": "background", "text": "The stepped care program Bridging Intervention in Anesthesiology ( BRIA ) aims at motivating and supporting surgical patients with comorbid mental disorders to engage in psychosocial mental healthcare options .", "sentence_id": 0}
+{"abstract_id": "25915712", "label": "background", "text": "This study examined the efficacy of BRIA .", "sentence_id": 1}
+{"abstract_id": "25915712", "label": "methods", "text": "This randomized , parallel-group , open-label , controlled trial was conducted in the preoperative anesthesiological assessment clinics and surgical wards of a large university hospital in Germany .", "sentence_id": 2}
+{"abstract_id": "25915712", "label": "methods", "text": "A total of @ surgical patients with comorbid mental disorders were randomized by using the computer-generated lists to one of two intervention groups : BRIA psychotherapy sessions up to @ months postoperatively ( BRIA ) versus no psychotherapy/computerized brief written advice ( BWA ) only .", "sentence_id": 3}
+{"abstract_id": "25915712", "label": "methods", "text": "Primary outcome was participation in psychosocial mental healthcare options at month @ .", "sentence_id": 4}
+{"abstract_id": "25915712", "label": "methods", "text": "Secondary outcome was change of self-reported general psychological distress ( Global Severity Index of the Brief Symptom Inventory ) between baseline and month @ .", "sentence_id": 5}
+{"abstract_id": "25915712", "label": "results", "text": "At @-month follow-up , the rate of patients who engaged in psychosocial mental healthcare options was @ % ( @ of @ ) in BRIA compared with @ % ( @ of @ ) in BWA ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25915712", "label": "results", "text": "Number needed to treat and relative risk reduction were @ ( @ % CI , @ to @ ) and @ ( @ to @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "25915712", "label": "results", "text": "In BRIA , Global Severity Index decreased between baseline and month @ ( P < @ ) , whereas it did not change significantly in BWA ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25915712", "label": "conclusions", "text": "Among surgical patients with comorbid mental disorders , BRIA results in an increased engagement in subsequent therapy options and a decrease of general psychological distress .", "sentence_id": 9}
+{"abstract_id": "25915712", "label": "conclusions", "text": "These data suggest that it is reasonable to integrate innovative psychotherapy programs into the context of interdisciplinary surgical care .", "sentence_id": 10}
+{"abstract_id": "24812543", "label": "objective", "text": "This study investigated the effects of fatty fish on sleep , daily functioning and biomarkers such as heart rate variability ( HRV ) , vitamin D status ( serum @-hydroxyvitamin D ( @OHD ) , and eicosapentaenoic acid ( EPA , @:@ n-@ ) + docosahexaenoic acid ( DHA , @:@ n-@ ) in red blood cells .", "sentence_id": 0}
+{"abstract_id": "24812543", "label": "objective", "text": "Moreover the relationship among sleep , daily functioning , HRV , vitamin D status , and levels of EPA+DHA was investigated .", "sentence_id": 1}
+{"abstract_id": "24812543", "label": "methods", "text": "Ninety-five male forensic patients from a secure forensic inpatient facility in the USA were randomly assigned into a Fish or a Control group .", "sentence_id": 2}
+{"abstract_id": "24812543", "label": "methods", "text": "The Fish group received Atlantic salmon three times per week from September to February , and the Control group was provided an alternative meal ( e.g. , chicken , pork , beef ) , but with the same nutritional value as their habitual diet , three times per week during the same period .", "sentence_id": 3}
+{"abstract_id": "24812543", "label": "methods", "text": "Sleep ( sleep latency , sleep efficiency , actual sleep time , and actual wake time ) , self-perceived sleep quality and daily functioning , as well as vitamin D status , EPA+DHA , and HRV , were assessed pre - and post-intervention period .", "sentence_id": 4}
+{"abstract_id": "24812543", "label": "results", "text": "There was a significant increase in sleep latency from pre - to post-test in the Control group .", "sentence_id": 5}
+{"abstract_id": "24812543", "label": "results", "text": "The Fish group reported better daily functioning than the Control group during post-test .", "sentence_id": 6}
+{"abstract_id": "24812543", "label": "results", "text": "Fish consumption throughout the wintertime had also an effect on resting HRV and EPA+DHA , but not on vitamin D status .", "sentence_id": 7}
+{"abstract_id": "24812543", "label": "results", "text": "However , at post-test , the vitamin D status in the Fish group was still closer to the level regarded as optimal compared to the Control group .", "sentence_id": 8}
+{"abstract_id": "24812543", "label": "results", "text": "Vitamin D status correlated negatively with actual wake time and positively with sleep efficiency during pre-test , as well as positively with daily functioning and sleep quality during post-test .", "sentence_id": 9}
+{"abstract_id": "24812543", "label": "results", "text": "Finally , HRV correlated negatively with sleep latency and positively with daily functioning .", "sentence_id": 10}
+{"abstract_id": "24812543", "label": "conclusions", "text": "Fish consumption seemed to have a positive impact on sleep in general and also on daily functioning , which may be related to vitamin D status and HRV .", "sentence_id": 11}
+{"abstract_id": "25092547", "label": "objective", "text": "Neurocysticercosis ( NCC ) is a major cause of seizures and epilepsy in endemic countries .", "sentence_id": 0}
+{"abstract_id": "25092547", "label": "objective", "text": "Antiparasitic treatment of brain cysts leads to seizures due to the host 's inflammatory reaction , requiring concomitant steroids .", "sentence_id": 1}
+{"abstract_id": "25092547", "label": "objective", "text": "We hypothesized that increased steroid dosing will reduce treatment-associated seizures .", "sentence_id": 2}
+{"abstract_id": "25092547", "label": "methods", "text": "Open-label randomized trial comparing @ mg/day dexamethasone for @ days ( conventional ) with @ mg/day for @ days followed by a @-week taper ( enhanced ) in patients with NCC receiving albendazole .", "sentence_id": 3}
+{"abstract_id": "25092547", "label": "methods", "text": "Follow-up included active seizure surveillance and brain imaging .", "sentence_id": 4}
+{"abstract_id": "25092547", "label": "methods", "text": "Study outcomes were seizure days and patients with seizures , both measured in days @-@ .", "sentence_id": 5}
+{"abstract_id": "25092547", "label": "methods", "text": "Additional analyses compared days @-@ , @-@ , @-@ , @-@ , @-@ , and @-@ .", "sentence_id": 6}
+{"abstract_id": "25092547", "label": "results", "text": "Thirty-two individuals were randomized into each study arm ; two did not complete follow-up .", "sentence_id": 7}
+{"abstract_id": "25092547", "label": "results", "text": "From days @ to @ , @ partial and @ generalized seizure days occurred in @ individuals , nonsignificantly fewer in the enhanced arm ( @ vs. @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25092547", "label": "results", "text": "The numbers of patients with seizures in this period showed similar nonsignificant differences .", "sentence_id": 9}
+{"abstract_id": "25092547", "label": "results", "text": "In the enhanced steroid arm there were significantly fewer days and individuals with seizures during antiparasitic treatment ( days @-@ : @ vs. @ , p = @ , and @ vs. @ , p = @ , number needed to treat -LSB- NNT -RSB- @ , relative risk -LSB- RR -RSB- @ , @ % confidence interval -LSB- CI -RSB- @-@ @ ) and early after dexamethasone cessation ( days @-@ : @ vs. @ , p = @ , and @ vs. @ , p = @ , NNT @ , RR @ , @ % CI @-@ @ ) but not after day @ .", "sentence_id": 10}
+{"abstract_id": "25092547", "label": "results", "text": "There were no significant differences in antiparasitic efficacy or relevant adverse events .", "sentence_id": 11}
+{"abstract_id": "25092547", "label": "conclusions", "text": "Increased dexamethasone dosing results in fewer seizures for the first @ days during and early after antiparasitic treatment for viable parenchymal NCC but not during the first @-@ days , which was the primary predetermined time of analysis .", "sentence_id": 12}
+{"abstract_id": "24240611", "label": "objective", "text": "A strategy using mechanical chest compressions might improve the poor outcome in out-of-hospital cardiac arrest , but such a strategy has not been tested in large clinical trials .", "sentence_id": 0}
+{"abstract_id": "24240611", "label": "objective", "text": "To determine whether administering mechanical chest compressions with defibrillation during ongoing compressions ( mechanical CPR ) , compared with manual cardiopulmonary resuscitation ( manual CPR ) , according to guidelines , would improve @-hour survival .", "sentence_id": 1}
+{"abstract_id": "24240611", "label": "methods", "text": "Multicenter randomized clinical trial of @ patients with out-of-hospital cardiac arrest conducted between January @ and February @ in @ Swedish , @ British , and @ Dutch ambulance services and their referring hospitals .", "sentence_id": 2}
+{"abstract_id": "24240611", "label": "methods", "text": "Duration of follow-up was @ months .", "sentence_id": 3}
+{"abstract_id": "24240611", "label": "methods", "text": "Patients were randomized to receive either mechanical chest compressions ( LUCAS Chest Compression System , Physio-Control/Jolife AB ) combined with defibrillation during ongoing compressions ( n = @ ) or to manual CPR according to guidelines ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24240611", "label": "methods", "text": "Four-hour survival , with secondary end points of survival up to @ months with good neurological outcome using the Cerebral Performance Category ( CPC ) score .", "sentence_id": 5}
+{"abstract_id": "24240611", "label": "methods", "text": "A CPC score of @ or @ was classified as a good outcome .", "sentence_id": 6}
+{"abstract_id": "24240611", "label": "results", "text": "Four-hour survival was achieved in @ patients ( @ % ) with mechanical CPR and @ ( @ % ) with manual CPR ( risk difference , -@ % ; @ % CI , -@ % to @ % ; P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24240611", "label": "results", "text": "Survival with a CPC score of @ or @ occurred in @ ( @ % ) vs @ ( @ % ) ( risk difference , @ % ; @ % CI , -@ % to @ % ) at intensive care unit discharge , in @ ( @ % ) vs @ ( @ % ) ( risk difference , @ % ; @ % CI , -@ % to @ % ) at hospital discharge , in @ ( @ % ) vs @ ( @ % ) ( risk difference , @ % ; @ % CI , -@ % to @ % ) at @ month , and in @ ( @ % ) vs @ ( @ % ) ( risk difference , @ % ; @ % CI , -@ % to @ % ) at @ months with mechanical CPR and manual CPR , respectively .", "sentence_id": 8}
+{"abstract_id": "24240611", "label": "results", "text": "Among patients surviving at @ months , @ % in the mechanical CPR group and @ % in the manual CPR group had CPC scores of @ or @ .", "sentence_id": 9}
+{"abstract_id": "24240611", "label": "conclusions", "text": "Among adults with out-of-hospital cardiac arrest , there was no significant difference in @-hour survival between patients treated with the mechanical CPR algorithm or those treated with guideline-adherent manual CPR .", "sentence_id": 10}
+{"abstract_id": "24240611", "label": "conclusions", "text": "The vast majority of survivors in both groups had good neurological outcomes by @ months .", "sentence_id": 11}
+{"abstract_id": "24240611", "label": "conclusions", "text": "In clinical practice , mechanical CPR using the presented algorithm did not result in improved effectiveness compared with manual CPR .", "sentence_id": 12}
+{"abstract_id": "25237116", "label": "background", "text": "Parkinson 's disease ( PD ) has a progressive course and is characterized by the degeneration of dopaminergic neurons .", "sentence_id": 0}
+{"abstract_id": "25237116", "label": "background", "text": "Although no neuroprotective treatments for PD have been found to date , the endocannabinoid system has emerged as a promising target .", "sentence_id": 1}
+{"abstract_id": "25237116", "label": "methods", "text": "From a sample of @ patients consecutively evaluated in a specialized movement disorders outpatient clinic , we selected @ PD patients without dementia or comorbid psychiatric conditions .", "sentence_id": 2}
+{"abstract_id": "25237116", "label": "methods", "text": "Participants were assigned to three groups of seven subjects each who were treated with placebo , cannabidiol ( CBD ) @ mg/day or CBD @ mg/day .", "sentence_id": 3}
+{"abstract_id": "25237116", "label": "methods", "text": "One week before the trial and in the last week of treatment participants were assessed in respect to ( i ) motor and general symptoms score ( UPDRS ) ; ( ii ) well-being and quality of life ( PDQ-@ ) ; and ( iii ) possible neuroprotective effects ( BDNF and H ( @ ) - MRS ) .", "sentence_id": 4}
+{"abstract_id": "25237116", "label": "results", "text": "We found no statistically significant differences in UPDRS scores , plasma BDNF levels or H ( @ ) - MRS measures .", "sentence_id": 5}
+{"abstract_id": "25237116", "label": "results", "text": "However , the groups treated with placebo and CBD @ mg/day had significantly different mean total scores in the PDQ-@ ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25237116", "label": "conclusions", "text": "Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities ; however , studies with larger samples and specific objectives are required before definitive conclusions can be drawn .", "sentence_id": 7}
+{"abstract_id": "24273298", "label": "background", "text": "Gait training for patients with hemiparesis is carried out independently overground or on a treadmill .", "sentence_id": 0}
+{"abstract_id": "24273298", "label": "background", "text": "Several studies have shown differences in hemiparetic gait parameters during overground versus treadmill walking .", "sentence_id": 1}
+{"abstract_id": "24273298", "label": "background", "text": "However , few studies have compared the effects of these @ gait training conditions on gait parameters , and no study has compared the short-term effects of these techniques on all biomechanical gait parameters .", "sentence_id": 2}
+{"abstract_id": "24273298", "label": "objective", "text": "To determine whether a gait training session performed overground or on a treadmill induces specific short-term effects on biomechanical gait parameters in patients with hemiparesis .", "sentence_id": 3}
+{"abstract_id": "24273298", "label": "methods", "text": "Twenty-six subjects with hemiparesis were randomly assigned to a single session of either overground or treadmill gait training .", "sentence_id": 4}
+{"abstract_id": "24273298", "label": "methods", "text": "The short-term effects on spatiotemporal , kinematic , and kinetic gait parameters were assessed using gait analysis before and immediately after the training and after a @-minute rest .", "sentence_id": 5}
+{"abstract_id": "24273298", "label": "results", "text": "Speed , cadence , percentage of single support phase , peak knee extension , peak propulsion , and braking on the paretic side were significantly increased after the gait training session .", "sentence_id": 6}
+{"abstract_id": "24273298", "label": "results", "text": "However , there were no specific changes dependent on the type of gait training performed ( overground or on a treadmill ) .", "sentence_id": 7}
+{"abstract_id": "24273298", "label": "conclusions", "text": "A gait training session performed by subjects with hemiparesis overground or on a treadmill did not induce specific short-term effects on biomechanical gait parameters .", "sentence_id": 8}
+{"abstract_id": "24273298", "label": "conclusions", "text": "The increase in gait velocity that followed a gait training session seemed to reflect specific modifications of the paretic lower limb and adaptation of the nonparetic lower limb .", "sentence_id": 9}
+{"abstract_id": "25062861", "label": "background", "text": "Virtual visits through web-based video conferencing can increase access to specialty care for individuals with Huntington disease ( HD ) and facilitate research participation .", "sentence_id": 0}
+{"abstract_id": "25062861", "label": "objective", "text": "To determine the feasibility of conducting virtual visits directly into the homes of individuals with HD , to assess the reliability of conducting remote versus in-person motor assessments , and to determine the test-retest reliability of conducting motor assessments remotely .", "sentence_id": 1}
+{"abstract_id": "25062861", "label": "methods", "text": "Individuals with mild to moderate HD underwent baseline in-person clinic assessments and completed a HD care survey .", "sentence_id": 2}
+{"abstract_id": "25062861", "label": "methods", "text": "Participants were randomized to receive three virtual visits from one of two physicians over four months that included a modified Unified Huntington 's Disease Rating Scale motor examination ( excluding rigidity and balance assessments ) via web-based video conferencing .", "sentence_id": 3}
+{"abstract_id": "25062861", "label": "methods", "text": "Intraclass coefficients ( ICC ) were calculated to determine the level of agreement between remote and in-person assessments .", "sentence_id": 4}
+{"abstract_id": "25062861", "label": "methods", "text": "Participants also completed a survey on their interest in telemedicine .", "sentence_id": 5}
+{"abstract_id": "25062861", "label": "results", "text": "Thirteen individuals underwent baseline assessments , eleven ( @ % ) participants completed at least one virtual visit , and @ ( @ % ) of @ total virtual visits were completed .", "sentence_id": 6}
+{"abstract_id": "25062861", "label": "results", "text": "Remote motor scores demonstrated good reliability ( ICC = @ ; n = @ ) compared to in-person motor scores .", "sentence_id": 7}
+{"abstract_id": "25062861", "label": "results", "text": "Test-retest reliability of motor scores conducted remotely was excellent ( ICC = @ ; n = @ ) .", "sentence_id": 8}
+{"abstract_id": "25062861", "label": "results", "text": "Participants expressed moderate future interest in using virtual visits to participate in research and to receive care .", "sentence_id": 9}
+{"abstract_id": "25062861", "label": "conclusions", "text": "In this pilot study , virtual visits into the home were feasible and reliable for conducting motor assessments in HD .", "sentence_id": 10}
+{"abstract_id": "25062861", "label": "conclusions", "text": "Larger scale studies need to confirm and generalize these findings to a broader population of participants .", "sentence_id": 11}
+{"abstract_id": "24962503", "label": "objective", "text": "To improve adolescent notification of positive sexually transmitted infection ( STI ) tests using mobile phone technology and STI information cards .", "sentence_id": 0}
+{"abstract_id": "24962503", "label": "methods", "text": "A randomized intervention among @ - to @-year olds in a pediatric emergency department ( PED ) .", "sentence_id": 1}
+{"abstract_id": "24962503", "label": "methods", "text": "A @ @ factorial design with replication was used to evaluate the effectiveness of six combinations of two factors on the proportion of STI-positive adolescents notified within @days of testing .", "sentence_id": 2}
+{"abstract_id": "24962503", "label": "methods", "text": "Independent factors included method of notification ( call , text message , or call + text message ) and provision of an STI information card with or without a phone number to obtain results .", "sentence_id": 3}
+{"abstract_id": "24962503", "label": "methods", "text": "Covariates for logistic regression included age , empiric STI treatment , days until first attempted notification , and documentation of confidential phone number .", "sentence_id": 4}
+{"abstract_id": "24962503", "label": "results", "text": "Approximately half of the @ females and @ males enrolled were @years of age .", "sentence_id": 5}
+{"abstract_id": "24962503", "label": "results", "text": "Texting only or type of card was not significantly associated with patient notification rates , and there was no significant interaction between card and notification method .", "sentence_id": 6}
+{"abstract_id": "24962503", "label": "results", "text": "For females , successful notification was significantly greater for call + text message ( odds ratio , @ ; @ % confidence interval , @-@ @ ) , and documenting a confidential phone number was independently associated with successful notification ( odds ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24962503", "label": "results", "text": "We found no significant predictors of successful notification for males .", "sentence_id": 8}
+{"abstract_id": "24962503", "label": "results", "text": "Of patients with a documented confidential phone number who received a call + text message , @ % of females and @ % of males were successfully notified .", "sentence_id": 9}
+{"abstract_id": "24962503", "label": "conclusions", "text": "Obtaining a confidential phone number and using call + text message improved STI notification rates among female but not male adolescents in a pediatric emergency department .", "sentence_id": 10}
+{"abstract_id": "24379072", "label": "objective", "text": "To investigate biochemically whether total intravenous anesthesia ( TIVA ) using propofol creates a risk for Propofol Infusion Syndrome ( PRIS ) .", "sentence_id": 0}
+{"abstract_id": "24379072", "label": "methods", "text": "Forty patients scheduled for thyroid gland surgery were randomly assigned into Group T or C and premedicated @ min before operation .", "sentence_id": 1}
+{"abstract_id": "24379072", "label": "methods", "text": "Group T received remifentanyl hydrochloride , propofol infusion following anesthesia induction with propofol , vecuronium bromide and intubation .", "sentence_id": 2}
+{"abstract_id": "24379072", "label": "methods", "text": "Group C received remifentanyl hydrochloride infusion , @-@ @ MAC desflurane inhalation following anesthesia induction with thiopental , vecuronium bromide and intubation .", "sentence_id": 3}
+{"abstract_id": "24379072", "label": "methods", "text": "Patients were respired @ % O@-air mixture .", "sentence_id": 4}
+{"abstract_id": "24379072", "label": "methods", "text": "Blood gas , potassium , lactic acid , CK-MB , myoglobin , troponin I , total carnitine , triglyceride , creatinine concentrations were determined before operation , at intraoperative hour-@ , postoperative hour-@ .", "sentence_id": 5}
+{"abstract_id": "24379072", "label": "results", "text": "There were no significant differences between groups in potassium , lactic acid CK-MB , myoglobin , total carnitine or creatinine levels .", "sentence_id": 6}
+{"abstract_id": "24379072", "label": "results", "text": "Triglyceride level at intraoperative hour-@ increased in Group T , decreased at postoperative hour-@ .", "sentence_id": 7}
+{"abstract_id": "24379072", "label": "results", "text": "Troponin I was higher in Group C than Group T at intraoperative hour-@ ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24379072", "label": "results", "text": "No asystole , bradycardia , arrhythmia , hypotension or change in urine color was detected .", "sentence_id": 9}
+{"abstract_id": "24379072", "label": "conclusions", "text": "The present biochemical findings suggest that TIVA using propofol is safe .", "sentence_id": 10}
+{"abstract_id": "25687878", "label": "objective", "text": "Traditional rotation-based models of placebo nausea are limited because they do not have vehicle settings and are tied to their context .", "sentence_id": 0}
+{"abstract_id": "25687878", "label": "objective", "text": "The present study introduces a new model for examining placebo-induced nausea in the laboratory that overcomes these limitations , namely , Galvanic Vestibular Stimulation ( GVS ) .", "sentence_id": 1}
+{"abstract_id": "25687878", "label": "objective", "text": "GVS stimulates the vestibular system to cause nausea through sensory mismatch with visual cues and importantly has a non-nauseating placebo setting .", "sentence_id": 2}
+{"abstract_id": "25687878", "label": "objective", "text": "Using this , we tested whether conditioning could elicit placebo nausea when participants were later exposed to placebo stimulation as well as whether this placebo nausea was generalised across contexts -- something that is extremely difficult to test with rotation-based models of placebo nausea .", "sentence_id": 3}
+{"abstract_id": "25687878", "label": "methods", "text": "Thirty healthy undergraduate students were randomised to receive either placebo GVS ( controls ) or active GVS during training ( Context-Consistent and Context-Change ) .", "sentence_id": 4}
+{"abstract_id": "25687878", "label": "methods", "text": "On test , all groups received placebo GVS .", "sentence_id": 5}
+{"abstract_id": "25687878", "label": "methods", "text": "The controls and Context-Consistent groups were tested in the same context as training , whereas the Context-Change group was tested in a new context .", "sentence_id": 6}
+{"abstract_id": "25687878", "label": "results", "text": "Participants conditioned with nausea during training had significantly higher nausea symptom ratings after placebo stimulation on test than those given no conditioning .", "sentence_id": 7}
+{"abstract_id": "25687878", "label": "results", "text": "This placebo-induced nausea also generalised to a novel test context with no differences observed between the Context-Change and Context-Consistent groups .", "sentence_id": 8}
+{"abstract_id": "25687878", "label": "conclusions", "text": "GVS provides a new model of placebo-induced nausea that overcomes limitations to traditional rotation-based paradigms .", "sentence_id": 9}
+{"abstract_id": "25687878", "label": "conclusions", "text": "Future studies should use this device to explore the effect of instructions and conditioning on the development of placebo nausea and to assess the efficacy of conditioning-based interventions for clinical use .", "sentence_id": 10}
+{"abstract_id": "24529654", "label": "background", "text": "Contrasting results have been reported regarding the influence of the use of adhesive on biofilm formation .", "sentence_id": 0}
+{"abstract_id": "24529654", "label": "objective", "text": "The purpose of this study was to evaluate the influence of the use of adhesive on the formation of biofilm on the internal surface of complete dentures and the palatal mucosa of denture wearers .", "sentence_id": 1}
+{"abstract_id": "24529654", "label": "methods", "text": "Thirty participants with well-fitting complete dentures were randomly divided according to the experimental design : protocol @ , adhesive use during the first @ days , followed by no use of adhesive over the next @ days ; protocol @ , no use of adhesives during the first @ days , followed by adhesive use over the next @ days .", "sentence_id": 2}
+{"abstract_id": "24529654", "label": "methods", "text": "After each period , material from the mucosa and intaglio of the maxillary dentures was collected .", "sentence_id": 3}
+{"abstract_id": "24529654", "label": "methods", "text": "Replicate aliquots were plated onto Petri dishes containing selective media for Candida spp , Streptococcus mutans , and a nonselective culture medium .", "sentence_id": 4}
+{"abstract_id": "24529654", "label": "methods", "text": "Colony-forming units were expressed as log ( CFU +@ ) / mL .", "sentence_id": 5}
+{"abstract_id": "24529654", "label": "methods", "text": "In addition , the internal surfaces of the maxillary and mandibular complete dentures were stained and photographed .", "sentence_id": 6}
+{"abstract_id": "24529654", "label": "methods", "text": "From the photographs , the total internal surface and the surface stained with biofilm were quantified ( software ImageTool @ ) , and the percentage of the biofilm-covered area ( % ) on the maxillary and mandibular dentures was calculated and compared with @-way ANOVA .", "sentence_id": 7}
+{"abstract_id": "24529654", "label": "methods", "text": "For the nonselective culture medium , data were compared with the paired-sample t test , and the Wilcoxon signed rank test was performed to compare the colony counts of Candida spp and Streptococcus mutans ( = @ ) .", "sentence_id": 8}
+{"abstract_id": "24529654", "label": "results", "text": "Similar colony counts were found with or without the use of adhesive for the mucosa and internal surfaces of maxillary dentures , irrespective of the culture medium ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24529654", "label": "results", "text": "The area of dentures covered with biofilm was influenced by the use of adhesive ( P = @ ) , regardless of the type of denture ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24529654", "label": "conclusions", "text": "The use of adhesive did not alter the colony counts of microorganisms from the palatal mucosa and maxillary dentures of complete denture wearers during the @-day period , but it did influence the area covered with biofilm on the internal surfaces of the complete dentures .", "sentence_id": 11}
+{"abstract_id": "24645966", "label": "objective", "text": "To compare the efficacy and tolerability of a low-volume ( @-L ) polyethylene glycol ( PEG ) regimen for colonoscopy compared to single ( @-L ) or split-dose ( @-L +@ - L ) regimens .", "sentence_id": 0}
+{"abstract_id": "24645966", "label": "methods", "text": "In-hospital patients who were candidates for colonoscopy were randomly assigned to : group @ single-dose ( PEG @L the day before the study , n = @ ) ; group @ : split-dose ( @L the day before and @L on the day of the procedure , n = @ ) ; and group @ : low-volume @-L PEG solution ( the day of the procedure , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24645966", "label": "methods", "text": "A blinded evaluation of the quality of colonic preparation was assessed by the Boston bowel preparation scale .", "sentence_id": 2}
+{"abstract_id": "24645966", "label": "results", "text": "Satisfactory bowel preparation of the right colon was more frequently reported for group @ than for group @ ( @ % vs @ % , P = @ ) , in the transverse colon it was @ % versus @ % ( P = @ ) , and on the left side of the colon it was @ % versus @ % ( P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24645966", "label": "results", "text": "Compared to group @ , satisfactory bowel preparation in group @ was similar in the transverse colon and left colon .", "sentence_id": 4}
+{"abstract_id": "24645966", "label": "results", "text": "Nausea , vomiting , and abdominal discomfort were less frequent in patients of group @ .", "sentence_id": 5}
+{"abstract_id": "24645966", "label": "results", "text": "Patients in group @ had fewer sleep disorders and fewer hours of sleep loss compared to patients in the other groups .", "sentence_id": 6}
+{"abstract_id": "24645966", "label": "conclusions", "text": "Preparation with @L caused less abdominal discomfort and fewer sleep disorders .", "sentence_id": 7}
+{"abstract_id": "24645966", "label": "conclusions", "text": "The split dose had a better quality of preparation in the right colon .", "sentence_id": 8}
+{"abstract_id": "24645966", "label": "conclusions", "text": "Both preparations were clearly better than the @-L preparation .", "sentence_id": 9}
+{"abstract_id": "24861837", "label": "background", "text": "Traditional Chinese medicine ( TCM ) is considered an important complementary therapy with beneficial effects for cancer patients .", "sentence_id": 0}
+{"abstract_id": "24861837", "label": "background", "text": "Elderly patients with non-small-cell lung cancer ( NSCLC ) are a complex patient group with increasing co-morbidity and shrinking physiological reserve , and may derive substantial benefit from the supportive aspects of TCM .", "sentence_id": 1}
+{"abstract_id": "24861837", "label": "background", "text": "Researchers from Shanghai Longhua Hospital found that qi and yin deficiency is a common syndrome in patients with stage III or IV lung cancer .", "sentence_id": 2}
+{"abstract_id": "24861837", "label": "background", "text": "This project was designed to study the combination of single-agent chemotherapy with TCM methods of benefiting qi and yin in elderly patients with advanced NSCLC .", "sentence_id": 3}
+{"abstract_id": "24861837", "label": "methods", "text": "This is a double-blind controlled , multi-center , and prospective study with randomly selected participants from elderly NSCLC patients in China .", "sentence_id": 4}
+{"abstract_id": "24861837", "label": "methods", "text": "Seventy-six patients who meet the inclusion criteria will be allocated into two groups , which will receive treatments of @-week single-agent chemotherapy with TCM or placebo for four cycles .", "sentence_id": 5}
+{"abstract_id": "24861837", "label": "methods", "text": "Progression-free survival ( PFS ) is the primary end point , and the secondary end points are overall survival , objective response rate , time-to-progression , and quality of life ( EORTC QLQ-LC@ , and TCM syndrome score ) .", "sentence_id": 6}
+{"abstract_id": "24861837", "label": "methods", "text": "Meanwhile , other end points such as toxicity , side effects and safety of the treatments will be assessed .", "sentence_id": 7}
+{"abstract_id": "24861837", "label": "conclusions", "text": "Results from this study may provide evidence on the effectiveness , and parameters for the usage of single-agent chemotherapy combined with or without TCM on PFS of elderly patients with NSCLC .", "sentence_id": 8}
+{"abstract_id": "25592987", "label": "background", "text": "Coadministration of a bacterial adjuvant with oral immunotherapy ( OIT ) has been suggested as a potential treatment for food allergy .", "sentence_id": 0}
+{"abstract_id": "25592987", "label": "objective", "text": "To evaluate a combined therapy comprising a probiotic together with peanut OIT .", "sentence_id": 1}
+{"abstract_id": "25592987", "label": "methods", "text": "We performed a double-blind , placebo-controlled randomized trial of the probiotic Lactobacillus rhamnosus CGMCC @ and peanut OIT ( probiotic and peanut oral immunotherapy -LSB- PPOIT -RSB- ) in children ( @-@ years ) with peanut allergy .", "sentence_id": 2}
+{"abstract_id": "25592987", "label": "methods", "text": "The primary outcome was induction of sustained unresponsiveness @ to @ weeks after discontinuation of treatment ( referred to as possible sustained unresponsiveness ) .", "sentence_id": 3}
+{"abstract_id": "25592987", "label": "methods", "text": "Secondary outcomes were desensitization , peanut skin prick test , and specific IgE and specific IgG@ measurements .", "sentence_id": 4}
+{"abstract_id": "25592987", "label": "results", "text": "Sixty-two children were randomized and stratified by age ( @ and > @ years ) and peanut skin test wheal size ( @ and > @ mm ) ; @ reached the trial 's end .", "sentence_id": 5}
+{"abstract_id": "25592987", "label": "results", "text": "Baseline demographics were similar across groups .", "sentence_id": 6}
+{"abstract_id": "25592987", "label": "results", "text": "Possible sustained unresponsiveness was achieved in @ % receiving PPOIT and @ % receiving placebo ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25592987", "label": "results", "text": "Nine children need to be treated for @ to achieve sustained unresponsiveness ( number needed to treat , @ ; @ % CI , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25592987", "label": "results", "text": "Of the subjects , @ % receiving PPOIT and @ % receiving placebo were desensitized ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25592987", "label": "results", "text": "PPOIT was associated with reduced peanut skin prick test responses and peanut-specific IgE levels and increased peanut-specific IgG@ levels ( all P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25592987", "label": "results", "text": "PPOIT-treated participants reported a greater number of adverse events , mostly with maintenance home dosing .", "sentence_id": 11}
+{"abstract_id": "25592987", "label": "conclusions", "text": "This is the first randomized placebo-controlled trial evaluating the novel coadministration of a probiotic and peanut OIT and assessing sustained unresponsiveness in children with peanut allergy .", "sentence_id": 12}
+{"abstract_id": "25592987", "label": "conclusions", "text": "PPOIT was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response .", "sentence_id": 13}
+{"abstract_id": "25592987", "label": "conclusions", "text": "Further work is required to confirm sustained unresponsiveness after a longer period of secondary peanut elimination and to clarify the relative contributions of probiotics versus OIT .", "sentence_id": 14}
+{"abstract_id": "24331381", "label": "background", "text": "Atopic dermatitis ( AD ) is a common inflammatory skin disease with a global prevalence ranging from @ % to @ % .", "sentence_id": 0}
+{"abstract_id": "24331381", "label": "background", "text": "Patients with AD have an increased risk for complications after viral infection ( eg , herpes simplex virus ) , and vaccination of patients with AD with live vaccinia virus is contraindicated because of a heightened risk of eczema vaccinatum , a rare but potentially lethal complication associated with smallpox vaccination .", "sentence_id": 1}
+{"abstract_id": "24331381", "label": "objective", "text": "We sought to develop a better understanding of immunity to cutaneous viral infection in patients with AD .", "sentence_id": 2}
+{"abstract_id": "24331381", "label": "methods", "text": "In a double-blind randomized study we investigated the safety and immunogenicity of live attenuated yellow fever virus ( YFV ) vaccination of nonatopic subjects and patients with AD after standard subcutaneous inoculation or transcutaneous vaccination administered with a bifurcated needle .", "sentence_id": 3}
+{"abstract_id": "24331381", "label": "methods", "text": "Viremia , neutralizing antibody , and antiviral T-cell responses were analyzed for up to @ days after vaccination .", "sentence_id": 4}
+{"abstract_id": "24331381", "label": "results", "text": "YFV vaccination administered through either route was well tolerated .", "sentence_id": 5}
+{"abstract_id": "24331381", "label": "results", "text": "Subcutaneous vaccination resulted in higher seroconversion rates than transcutaneous vaccination but elicited similar antiviral antibody levels and T-cell responses in both the nonatopic and AD groups .", "sentence_id": 6}
+{"abstract_id": "24331381", "label": "results", "text": "After transcutaneous vaccination , both groups mounted similar neutralizing antibody responses , but patients with AD demonstrated lower antiviral T-cell responses by @ days after vaccination .", "sentence_id": 7}
+{"abstract_id": "24331381", "label": "results", "text": "Among transcutaneously vaccinated subjects , a significant inverse correlation between baseline IgE levels and the magnitude of antiviral antibody and CD@ ( + ) T-cell responses was observed .", "sentence_id": 8}
+{"abstract_id": "24331381", "label": "conclusions", "text": "YFV vaccination of patients with AD through the transcutaneous route revealed that high baseline IgE levels provide a potential biomarker for predicting reduced virus-specific immune memory after transcutaneous infection with a live virus .", "sentence_id": 9}
+{"abstract_id": "25807399", "label": "background", "text": "Optimal resuscitation of hypotensive trauma patients has not been defined .", "sentence_id": 0}
+{"abstract_id": "25807399", "label": "background", "text": "This trial was performed to assess the feasibility and safety of controlled resuscitation ( CR ) versus standard resuscitation ( SR ) in hypotensive trauma patients .", "sentence_id": 1}
+{"abstract_id": "25807399", "label": "methods", "text": "Patients were enrolled and randomized in the out-of-hospital setting .", "sentence_id": 2}
+{"abstract_id": "25807399", "label": "methods", "text": "Nineteen emergency medical services ( EMS ) systems in the Resuscitation Outcome Consortium participated .", "sentence_id": 3}
+{"abstract_id": "25807399", "label": "methods", "text": "Eligible patients had an out-of-hospital systolic blood pressure ( SBP ) of @ mm Hg or lower .", "sentence_id": 4}
+{"abstract_id": "25807399", "label": "methods", "text": "CR patients received @ mL of fluid if they had no radial pulse or an SBP lower than @ mm Hg and additional @-mL boluses to maintain a radial pulse or an SBP of @ mm Hg or greater .", "sentence_id": 5}
+{"abstract_id": "25807399", "label": "methods", "text": "The SR group patients received @ L initially and additional fluid as needed to maintain an SBP of @ mm Hg or greater .", "sentence_id": 6}
+{"abstract_id": "25807399", "label": "methods", "text": "The crystalloid protocol was maintained until hemorrhage control or @ hours after hospital arrival .", "sentence_id": 7}
+{"abstract_id": "25807399", "label": "results", "text": "A total of @ patients were randomized ( @ CR and @ SR ) .", "sentence_id": 8}
+{"abstract_id": "25807399", "label": "results", "text": "The CR and SR groups were similar at baseline .", "sentence_id": 9}
+{"abstract_id": "25807399", "label": "results", "text": "The mean ( SD ) crystalloid volume administered during the study period was @ L ( @ ) in the CR group and @ L ( @ ) in the SR group , a difference of @ L ( @ % confidence interval -LSB- CI -RSB- , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25807399", "label": "results", "text": "Intensive care unit-free days , ventilator-free days , renal injury , and renal failure did not differ between the groups .", "sentence_id": 11}
+{"abstract_id": "25807399", "label": "results", "text": "At @ hours after admission , there were @ deaths ( @ % ) in the CR group and @ ( @ % ) in the SR group ( adjusted odds ratio , @ ; @ % CI , @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "25807399", "label": "results", "text": "Among patients with blunt trauma , @-hour mortality was @ % ( CR ) and @ % ( SR ) with an adjusted odds ratio of @ ( @-@ @ ) .", "sentence_id": 13}
+{"abstract_id": "25807399", "label": "results", "text": "There was no difference among patients with penetrating trauma ( @ % vs. @ % ; adjusted odds ratio , @ ; @ % CI , @-@ @ ) .", "sentence_id": 14}
+{"abstract_id": "25807399", "label": "conclusions", "text": "CR is achievable in out-of-hospital and hospital settings and may offer an early survival advantage in blunt trauma .", "sentence_id": 15}
+{"abstract_id": "25807399", "label": "conclusions", "text": "A large-scale , Phase III trial to examine its effects on survival and other clinical outcomes is warranted .", "sentence_id": 16}
+{"abstract_id": "25807399", "label": "methods", "text": "Therapeutic study , level I.", "sentence_id": 17}
+{"abstract_id": "25256183", "label": "objective", "text": "Early and intensive blood pressure-lowering treatment seems to be beneficial in patients with acute hemorrhagic stroke and high blood pressure .", "sentence_id": 0}
+{"abstract_id": "25256183", "label": "objective", "text": "We wanted to see if similar benefits can be shown from a later and more gradual blood pressure lowering , using data from the Scandinavian Candesartan Acute Stroke Trial ( SCAST ) .", "sentence_id": 1}
+{"abstract_id": "25256183", "label": "methods", "text": "SCAST was a randomized - and placebo-controlled , double-masked trial of candesartan given for @ days , in @ patients with acute stroke and systolic blood pressure @ mm Hg .", "sentence_id": 2}
+{"abstract_id": "25256183", "label": "methods", "text": "We assessed the effects of candesartan in the @ patients with hemorrhagic stroke , using the trial 's @ coprimary effect variables : the composite vascular end point of vascular death , stroke or myocardial infarction , and functional outcome at @ months , according to the modified Rankin Scale .", "sentence_id": 3}
+{"abstract_id": "25256183", "label": "methods", "text": "We used Cox proportional hazards models and ordinal regression for analysis and adjusted for key , predefined prognostic variables .", "sentence_id": 4}
+{"abstract_id": "25256183", "label": "results", "text": "There was no association between treatment with candesartan and risk of vascular events ( @ of @ -LSB- @ % -RSB- versus @ of @ -LSB- @ % -RSB- ; hazard ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25256183", "label": "results", "text": "For functional outcome we found evidence of a negative effect of candesartan ( common odds ratio , @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25256183", "label": "conclusions", "text": "There was no evidence that blood pressure-lowering treatment with candesartan is beneficial during the first week of hemorrhagic stroke .", "sentence_id": 7}
+{"abstract_id": "25256183", "label": "conclusions", "text": "Instead , there were signs that such treatment may be harmful , but this needs to be verified in larger studies .", "sentence_id": 8}
+{"abstract_id": "25449513", "label": "background", "text": "The prognostic significance of long-term visit-to-visit blood pressure variability ( BPV ) has not yet been validated in `` real world '' hypertensive patients .", "sentence_id": 0}
+{"abstract_id": "25449513", "label": "background", "text": "The aim of the current study is to explore the prognostic value of BPV on stroke in hypertensive patients .", "sentence_id": 1}
+{"abstract_id": "25449513", "label": "methods", "text": "This was a dynamic prospective cohort study based on electronic medical records in Shanghai , China .", "sentence_id": 2}
+{"abstract_id": "25449513", "label": "methods", "text": "Hypertensive patients ( N = @,@ ) without history of stroke at baseline , were followed up from @ to @ .", "sentence_id": 3}
+{"abstract_id": "25449513", "label": "methods", "text": "The cohort comprised of @ stroke patients and @,@ non-stroke patients during a mean follow-up duration of @ months .", "sentence_id": 4}
+{"abstract_id": "25449513", "label": "methods", "text": "BPV was measured by standard deviation ( SD ) and the coefficient of variation ( CV ) of blood pressure .", "sentence_id": 5}
+{"abstract_id": "25449513", "label": "results", "text": "The visit-to-visit variability of both systolic blood pressure ( SBP ) and diastolic blood pressure ( DBP ) was independently associated with the occurrence of stroke -LSB- SD : the hazard ratios ( @ % confidence intervals ) of SBP and DBP were @ ( @ to @ ) and @ ( @ to @ ) ; CV : the hazard ratios ( @ % confidence intervals ) of SBP and DBP were @ ( @ to @ ) and @ ( @ to @ ) , respectively -RSB- .", "sentence_id": 6}
+{"abstract_id": "25449513", "label": "results", "text": "The hazard ratio values increased along with an increase of the BPV levels of SBP and DBP .", "sentence_id": 7}
+{"abstract_id": "25449513", "label": "results", "text": "The increment effect remained significant after controlling the blood pressure control status of subjects .", "sentence_id": 8}
+{"abstract_id": "25449513", "label": "conclusions", "text": "Increased BPV of both SBP and DBP , independent of the average blood pressure , is a predictor of stroke among community hypertensive patients in real-world clinical practice .", "sentence_id": 9}
+{"abstract_id": "25449513", "label": "conclusions", "text": "The risk of stroke increased along with increased BPV .", "sentence_id": 10}
+{"abstract_id": "25449513", "label": "conclusions", "text": "Stabilizing BPV might be a therapeutic target in hypertension .", "sentence_id": 11}
+{"abstract_id": "25271779", "label": "objective", "text": "Trichotillomania is a psychiatric condition characterized by the chronic pulling and plucking of one 's own hair .", "sentence_id": 0}
+{"abstract_id": "25271779", "label": "objective", "text": "Cognitive-behavioral therapy shows promise as a treatment for trichotillomania and might be preferable to pharmacotherapy .", "sentence_id": 1}
+{"abstract_id": "25271779", "label": "objective", "text": "However , there have been no randomized , controlled studies of the efficacy of group cognitive-behavioral therapy .", "sentence_id": 2}
+{"abstract_id": "25271779", "label": "methods", "text": "We evaluated @ subjects , recruited from April @ to May @ , all of whom met DSM-IV criteria for a diagnosis of trichotillomania .", "sentence_id": 3}
+{"abstract_id": "25271779", "label": "methods", "text": "Subjects were randomized to receive @ sessions of either group cognitive-behavioral therapy or group supportive therapy ( control ) .", "sentence_id": 4}
+{"abstract_id": "25271779", "label": "methods", "text": "Treatment evaluation was non-blind and used self-report scales .", "sentence_id": 5}
+{"abstract_id": "25271779", "label": "methods", "text": "The primary outcome measure was the improvement of hair-plucking behavior as assessed by the Massachusetts General Hospital Hairpulling Scale .", "sentence_id": 6}
+{"abstract_id": "25271779", "label": "methods", "text": "Secondary measures included scores on the Beck Depression Inventory , the Beck Anxiety Inventory , and the Social Adjustment Scale-Self-Report .", "sentence_id": 7}
+{"abstract_id": "25271779", "label": "results", "text": "Both groups showed significant posttreatment improvement in the scores from the Massachusetts General Hospital Hairpulling Scale ( F = @ , P < @ ) and the Beck Depression Inventory ( F = @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25271779", "label": "results", "text": "The decrease in hair-plucking behavior over time was significantly greater in the study group than in the control group ( F = @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25271779", "label": "results", "text": "There were no significant differences between the pretreatment and posttreatment time points or between the groups in the scores from the Beck Anxiety Inventory and the Social Adjustment Scale-Self-Report .", "sentence_id": 10}
+{"abstract_id": "25271779", "label": "conclusions", "text": "We conclude that group cognitive-behavioral therapy is a valid treatment for trichotillomania .", "sentence_id": 11}
+{"abstract_id": "25271779", "label": "conclusions", "text": "This treatment model should be further revised and expanded to address comorbidities such as anxiety and social maladjustment .", "sentence_id": 12}
+{"abstract_id": "25668198", "label": "background", "text": "Longitudinal data on bone mineral density ( BMD ) in children and adolescents with Prader-Willi Syndrome ( PWS ) during long-term GH treatment are not available .", "sentence_id": 0}
+{"abstract_id": "25668198", "label": "objective", "text": "This study aimed to determine effects of long-term GH treatment and puberty on BMD of total body ( BMDTB ) , lumbar spine ( BMDLS ) , and bone mineral apparent density of the lumbar spine ( BMADLS ) in children with PWS .", "sentence_id": 1}
+{"abstract_id": "25668198", "label": "methods", "text": "This was a prospective longitudinal study of a Dutch PWS cohort .", "sentence_id": 2}
+{"abstract_id": "25668198", "label": "methods", "text": "Seventy-seven children with PWS who remained prepubertal during GH treatment for @ years and @ children with PWS who received GH treatment for @ years participated in the study .", "sentence_id": 3}
+{"abstract_id": "25668198", "label": "methods", "text": "The children received GH treatment , @ mg/m ( @ ) / day ( @ mg/kg/d ) .", "sentence_id": 4}
+{"abstract_id": "25668198", "label": "methods", "text": "BMDTB , BMDLS , and BMADLS was measured by using the same dual-energy x-ray absorptiometry machine for all annual measurements .", "sentence_id": 5}
+{"abstract_id": "25668198", "label": "results", "text": "In the prepubertal group , BMDTB standard deviation score ( SDS ) and BMDLSSDS significantly increased during @ years of GH treatment whereas BMADLSSDS remained stable .", "sentence_id": 6}
+{"abstract_id": "25668198", "label": "results", "text": "During adolescence , BMDTBSDS and BMADLSSDS decreased significantly , in girls from the age of @ years and in boys from the ages of @ and @ years , respectively , but all BMD parameters remained within the normal range .", "sentence_id": 7}
+{"abstract_id": "25668198", "label": "results", "text": "Higher Tanner stages tended to be associated with lower BMDTBSDS ( P = @ ) and a significantly lower BMADLSSDS ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25668198", "label": "results", "text": "After @ years of GH treatment , lean body mass SDS was the most powerful predictor of BMDTBSDS and BMDLSSDS in adolescents with PWS .", "sentence_id": 9}
+{"abstract_id": "25668198", "label": "conclusions", "text": "This long-term GH study demonstrates that BMDTB , BMDLS , and BMADLS remain stable in prepubertal children with PWS but decreases during adolescence , parallel to incomplete pubertal development .", "sentence_id": 10}
+{"abstract_id": "25668198", "label": "conclusions", "text": "Based on our findings , clinicians should start sex hormone therapy from the age of @ years in girls and @ years in boys unless there is a normal progression of puberty .", "sentence_id": 11}
+{"abstract_id": "24676798", "label": "objective", "text": "To examine disordered eating and associations with health-related quality of life ( HRQOL ) in rural overweight/obese ( OW/OB ) children .", "sentence_id": 0}
+{"abstract_id": "24676798", "label": "methods", "text": "Cross-sectional analyses were conducted with @ rural OW/OB children aged @-@ years ( M = @ ; SD = @ ) .", "sentence_id": 1}
+{"abstract_id": "24676798", "label": "methods", "text": "Child anthropometrics , demographics , disordered eating attitudes , unhealthy weight control behaviors ( UWCBs ) , and HRQOL were measured .", "sentence_id": 2}
+{"abstract_id": "24676798", "label": "methods", "text": "Relationships between these variables were analyzed using bootstrapped multiple linear regressions .", "sentence_id": 3}
+{"abstract_id": "24676798", "label": "results", "text": "Clinically significant disordered eating attitudes were endorsed by @ % of the sample , and the majority endorsed UWCBs .", "sentence_id": 4}
+{"abstract_id": "24676798", "label": "results", "text": "Disordered eating attitudes and weight status were the most common predictors of HRQOL .", "sentence_id": 5}
+{"abstract_id": "24676798", "label": "results", "text": "Disordered eating attitudes and UWCBs were negatively related to emotional HRQOL but were unrelated to social , school , or physical HRQOL .", "sentence_id": 6}
+{"abstract_id": "24676798", "label": "conclusions", "text": "Disordered eating is a serious and relevant problem in OW/OB children living in rural areas and may be indicative of impairments in emotional functioning .", "sentence_id": 7}
+{"abstract_id": "24676798", "label": "conclusions", "text": "Early intervention may reduce the risk for eating disorders and associated negative sequelae .", "sentence_id": 8}
+{"abstract_id": "24344215", "label": "objective", "text": "From @ to @ , the International Berlin-Frankfurt-Mnster Study Group conducted a prospective randomized clinical trial ( ALL IC-BFM @ ) for the management of childhood acute lymphoblastic leukemia ( ALL ) in @ countries on three continents .", "sentence_id": 0}
+{"abstract_id": "24344215", "label": "objective", "text": "The aim of this trial was to explore the impact of differential delayed intensification ( DI ) on outcome in all risk groups .", "sentence_id": 1}
+{"abstract_id": "24344215", "label": "methods", "text": "For this trial , @,@ eligible patients were divided into three risk groups according to age , WBC , early treatment response , and unfavorable genetic aberrations .", "sentence_id": 2}
+{"abstract_id": "24344215", "label": "methods", "text": "DI was randomized as follows : standard risk ( SR ) , two @-week intensive elements ( protocol III ) versus one @-week protocol II ; intermediate risk ( IR ) , protocol III @ versus protocol II @ ; high risk ( HR ) , protocol III @ versus either protocol II @ ( Associazione Italiana Ematologia Oncologia Pediatrica -LSB- AIEOP -RSB- option ) , or @ HR blocks plus single protocol II ( Berlin-Frankfurt-Mnster -LSB- BFM -RSB- option ) .", "sentence_id": 3}
+{"abstract_id": "24344215", "label": "results", "text": "At @ years , the probabilities of event-free survival and survival were @ % ( @ % ) and @ % ( @ % ) for all @,@ eligible patients , @ % and @ % for the SR ( n = @,@ ) , @ % and @ % for the IR ( n = @,@ ) , and @ % and @ % for the HR ( n = @ ) groups , respectively .", "sentence_id": 4}
+{"abstract_id": "24344215", "label": "results", "text": "No improvement was accomplished by more intense and/or prolonged DI .", "sentence_id": 5}
+{"abstract_id": "24344215", "label": "conclusions", "text": "The ALL IC-BFM @ trial is a good example of international collaboration in pediatric oncology .", "sentence_id": 6}
+{"abstract_id": "24344215", "label": "conclusions", "text": "A wide platform of countries able to run randomized studies in ALL has been established .", "sentence_id": 7}
+{"abstract_id": "24344215", "label": "conclusions", "text": "Although the alternative DI did not improve outcome compared with standard treatment and the overall results are worse than those achieved by longer established leukemia groups , the national results have generally improved .", "sentence_id": 8}
+{"abstract_id": "26437532", "label": "objective", "text": "To evaluate the efficacy and safety of azithromycinfor treatment of uncomplicated pediatric scrub typhus .", "sentence_id": 0}
+{"abstract_id": "26437532", "label": "methods", "text": "A randomized controlled trial was performed .", "sentence_id": 1}
+{"abstract_id": "26437532", "label": "methods", "text": "We compared azithromycin with doxycycline or chloramphenicol in uncomplicated pediatric scrub typhus from inpatient pediatric department of Chiangrai Prachanukroh Hospital .", "sentence_id": 2}
+{"abstract_id": "26437532", "label": "methods", "text": "The primary outcome was cure rate at day @ .", "sentence_id": 3}
+{"abstract_id": "26437532", "label": "methods", "text": "The secondary outcomes were timing to defervescence within @ hours , side effects , and relapsed rate .", "sentence_id": 4}
+{"abstract_id": "26437532", "label": "methods", "text": "We compared data between both groups with Fisher 's exact test or Mann-Whitney U test , and failure rate was demonstrated by Kaplan-Meier survival curve and Log-rank test .", "sentence_id": 5}
+{"abstract_id": "26437532", "label": "results", "text": "We included @ patients , ofwhom , @ were assigned to doxycycline or chloramphenicol ( control group ) and @ to azithromycin ( study group ) .", "sentence_id": 6}
+{"abstract_id": "26437532", "label": "results", "text": "The baseline characteristics of both groups were similar The cure rate was @ % in the doxycycline or chloramphenicol group , as compared to @ % in the azithromycin group ( p = @ ) , and a median time to defervescence was @ hours ( IQR @ , @ ) vs. @ hours ( IQR @ , @ ) respectively ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "26437532", "label": "results", "text": "There was a little minor side effect in azithromycin group .", "sentence_id": 8}
+{"abstract_id": "26437532", "label": "results", "text": "No relapsed was found in either groups .", "sentence_id": 9}
+{"abstract_id": "26437532", "label": "conclusions", "text": "Azithromycin was as effective as doxycycline or chloramphenicol in treatment of uncomplicated pediatric scrub typhus .", "sentence_id": 10}
+{"abstract_id": "24509504", "label": "background", "text": "Obesity in youth remains a major public health issue .", "sentence_id": 0}
+{"abstract_id": "24509504", "label": "background", "text": "Yet no effective long-term preventive strategy exists .", "sentence_id": 1}
+{"abstract_id": "24509504", "label": "background", "text": "We previously showed that a school-based socio-ecological approach targeting behavior and social/environmental influences on physical activity ( PA ) prevented @-year excessive weight gain in @-year olds .", "sentence_id": 2}
+{"abstract_id": "24509504", "label": "background", "text": "In this study , we investigated if this efficacy persists @ months after intervention cessation .", "sentence_id": 3}
+{"abstract_id": "24509504", "label": "results", "text": "The program targeted students , family , school and the living environment to promote/support PA and prevent sedentary behavior ( SB ) .", "sentence_id": 4}
+{"abstract_id": "24509504", "label": "results", "text": "A total of @ students from eight randomized middle schools completed the @-year trial .", "sentence_id": 5}
+{"abstract_id": "24509504", "label": "results", "text": "At the @-month post-trial follow-up , body mass index ( BMI ) , fat mass index ( FMI ) , leisure PA ( LPA ) , home/school/workplace active commuting , TV/video time ( TVT ) , and attitudes toward PA were measured in @ adolescents .", "sentence_id": 6}
+{"abstract_id": "24509504", "label": "results", "text": "The beneficial effects of the intervention on the excess BMI increase ( +@ vs +@ kgm ( -@ ) in the intervention and control groups , respectively ) and on the overweight incidence in initially non-overweight students ( @ % vs @ % ; odds ratio = @ ( @ % confidence interval : @-@ @ ) ) were maintained at the post-trial follow-up .", "sentence_id": 7}
+{"abstract_id": "24509504", "label": "results", "text": "LPA was not maintained at the level achieved during the trial .", "sentence_id": 8}
+{"abstract_id": "24509504", "label": "results", "text": "However , we still observed a prevention of the age-related decrease of the adolescents ' percentage reporting regular LPA ( -@ % vs -@ % ) and a higher intention to exercise in the intervention group .", "sentence_id": 9}
+{"abstract_id": "24509504", "label": "results", "text": "The intervention promoted lower TVT ( -@ vs +@ min per day ) and higher active commuting changes ( +@ % vs -@ % ) .", "sentence_id": 10}
+{"abstract_id": "24509504", "label": "results", "text": "Trends in higher BMI reduction in students with high initial TVT and in the least wealthy group were noted .", "sentence_id": 11}
+{"abstract_id": "24509504", "label": "results", "text": "TVT changes throughout the follow-up predicted excess BMI and FMI changes .", "sentence_id": 12}
+{"abstract_id": "24509504", "label": "conclusions", "text": "Long-term multilevel approach targeting PA and SB prevents excessive weight gain up to @ months after intervention cessation .", "sentence_id": 13}
+{"abstract_id": "24509504", "label": "conclusions", "text": "The efficacy may be higher in the most sedentary and least wealthy adolescents .", "sentence_id": 14}
+{"abstract_id": "24509504", "label": "conclusions", "text": "Healthy PA-related behavior inducing long-lasting weight effects can be promoted in youth providing that an ecological approach is introduced in the prevention strategy .", "sentence_id": 15}
+{"abstract_id": "24843066", "label": "background", "text": "Adolescents with chronic disease ( ACD ) must develop independent disease self-management and learn to communicate effectively with their health care team to transition from pediatric to adult-oriented health care systems .", "sentence_id": 0}
+{"abstract_id": "24843066", "label": "background", "text": "Disease-specific interventions have been implemented to aid specific ACD groups through transition .", "sentence_id": 1}
+{"abstract_id": "24843066", "label": "background", "text": "A generic approach might be effective and cost-saving .", "sentence_id": 2}
+{"abstract_id": "24843066", "label": "methods", "text": "Eighty-one ACD , aged @ to @ years , were recruited for a randomized clinical trial evaluating an @-month transition intervention ( MD@Me ) .", "sentence_id": 3}
+{"abstract_id": "24843066", "label": "methods", "text": "MD@Me recipients received a @-month intensive Web-based and text-delivered disease management and skill-based intervention followed by a @-month review period .", "sentence_id": 4}
+{"abstract_id": "24843066", "label": "methods", "text": "MD@Me recipients also had access to a texting algorithm for disease assessment and health care team contact .", "sentence_id": 5}
+{"abstract_id": "24843066", "label": "methods", "text": "The intervention was applicable to adolescents with diverse chronic illnesses .", "sentence_id": 6}
+{"abstract_id": "24843066", "label": "methods", "text": "Controls received mailed materials on general health topics .", "sentence_id": 7}
+{"abstract_id": "24843066", "label": "methods", "text": "Disease management , health-related self-efficacy , and health assessments were performed at baseline and at @ and @ months .", "sentence_id": 8}
+{"abstract_id": "24843066", "label": "methods", "text": "Frequency of patient-initiated communications was recorded over the study period .", "sentence_id": 9}
+{"abstract_id": "24843066", "label": "methods", "text": "Outcomes were analyzed according to assigned treatment group over time .", "sentence_id": 10}
+{"abstract_id": "24843066", "label": "results", "text": "MD@Me recipients demonstrated significant improvements in performance of disease management tasks , health-related self-efficacy , and patient-initiated communications compared with controls .", "sentence_id": 11}
+{"abstract_id": "24843066", "label": "conclusions", "text": "Outcomes in ACD improved significantly among recipients of a generic , technology-based intervention .", "sentence_id": 12}
+{"abstract_id": "24843066", "label": "conclusions", "text": "Technology can deliver transition interventions to adolescents with diverse chronic illnesses , and a generic approach offers a cost-effective means of positively influencing transition outcomes .", "sentence_id": 13}
+{"abstract_id": "24843066", "label": "conclusions", "text": "Further research is needed to determine whether improved short-term outcomes translate into an improved transition for ACD .", "sentence_id": 14}
+{"abstract_id": "24877146", "label": "background", "text": "NK cells have anti-HIV activity mediated through killer cell immunoglobulin-like receptors ( KIRs ) .", "sentence_id": 0}
+{"abstract_id": "24877146", "label": "background", "text": "The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection in discordant couples ( DCs ) , where one spouse remains seronegative ( HSN ) despite repeated exposure to the HIV .", "sentence_id": 1}
+{"abstract_id": "24877146", "label": "methods", "text": "KIR was genotyped using PCR SSP .", "sentence_id": 2}
+{"abstract_id": "24877146", "label": "methods", "text": "Viral load and CD@ counts were estimated using commercially available reagents .", "sentence_id": 3}
+{"abstract_id": "24877146", "label": "methods", "text": "Data were analyzed using SPSS software .", "sentence_id": 4}
+{"abstract_id": "24877146", "label": "results", "text": "Among the @ DCs , HSN spouses had significantly ( P = @ ) higher frequencies of KIR@DS@ .", "sentence_id": 5}
+{"abstract_id": "24877146", "label": "results", "text": "Regression analysis revealed significant ( P = @ ) association of KIR@DS@ with low viral load .", "sentence_id": 6}
+{"abstract_id": "24877146", "label": "results", "text": "KIR@DS@ variant was associated ( P = @ ) with high viral load .", "sentence_id": 7}
+{"abstract_id": "24877146", "label": "results", "text": "Three pairs of KIR genes were in strong LD in HSNs and two pairs in HSPs .", "sentence_id": 8}
+{"abstract_id": "24877146", "label": "results", "text": "There were @ KIR genotypes , and @ are reported the first time in the Indian population .", "sentence_id": 9}
+{"abstract_id": "24877146", "label": "results", "text": "Exclusive genotypes were present either in HSPs ( N = @ , @ unique genotypes ) or in HSNs ( n = @ , @ unique genotypes ) .", "sentence_id": 10}
+{"abstract_id": "24877146", "label": "conclusions", "text": "This study highlights for the first time in the Indian population an association of KIR genes in HIV infection where presence of exclusive and unique genotypes indicates possible association with either HIV infection or with protection .", "sentence_id": 11}
+{"abstract_id": "25624132", "label": "background", "text": "Allergic rhinitis ( AR ) is an inflammatory condition of the nasal mucosa characterized by symptoms of nasal discharge , itching , sneezing , and congestion .", "sentence_id": 0}
+{"abstract_id": "25624132", "label": "background", "text": "Ocular symptoms are commonly associated with AR and include itching or burning , tearing or watering , and redness .", "sentence_id": 1}
+{"abstract_id": "25624132", "label": "background", "text": "Intranasal corticosteroids are a mainstay of treatment , and their effect on nasal symptoms is well described .", "sentence_id": 2}
+{"abstract_id": "25624132", "label": "objective", "text": "To demonstrate that a @-day course of @ g/d of nasal fluticasone propionate is superior to placebo in relieving ocular symptoms associated with AR .", "sentence_id": 3}
+{"abstract_id": "25624132", "label": "methods", "text": "This was a randomized , double-blind , parallel group , multicenter study comparing @ g/d of fluticasone propionate with placebo in patients with seasonal allergic rhinitis .", "sentence_id": 4}
+{"abstract_id": "25624132", "label": "methods", "text": "The primary end point was mean change from baseline in patient-rated reflective total ocular symptom score ( rTOSS ) .", "sentence_id": 5}
+{"abstract_id": "25624132", "label": "methods", "text": "Key secondary end points included mean change from baseline in the morning and evening rTOSS , end-of-treatment assessment of response , and effect on activities of daily living .", "sentence_id": 6}
+{"abstract_id": "25624132", "label": "methods", "text": "The primary analysis was performed using analysis of covariance with a linear fixed-effects model .", "sentence_id": 7}
+{"abstract_id": "25624132", "label": "results", "text": "Fluticasone was statistically significantly more efficacious in reducing the ocular symptoms of AR than placebo .", "sentence_id": 8}
+{"abstract_id": "25624132", "label": "results", "text": "The least squares mean difference in the change from baseline of rTOSS was -@ ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25624132", "label": "results", "text": "A statistically significant difference in mean change from baseline was observed in favor of fluticasone for morning and evening rTOSS .", "sentence_id": 10}
+{"abstract_id": "25624132", "label": "results", "text": "Significantly more patients taking fluticasone achieved an overall response compared with placebo .", "sentence_id": 11}
+{"abstract_id": "25624132", "label": "results", "text": "Fluticasone had a significantly greater effect on daily living activities and was well tolerated .", "sentence_id": 12}
+{"abstract_id": "25624132", "label": "conclusions", "text": "This study supports the efficacy of fluticasone in treating ocular symptoms associated with AR .", "sentence_id": 13}
+{"abstract_id": "26017129", "label": "background", "text": "The Checklist During Multidisciplinary Visits for Reduction of Mortality in Intensive Care Units ( Checklist - ICU ) trial is a pragmatic , two-arm , cluster-randomised trial involving @ intensive care units in Brazil , with the primary objective of determining if a multifaceted qualityimprovement intervention with a daily checklist , definition of daily care goals during multidisciplinary daily rounds and clinician prompts can reduce inhospital mortality .", "sentence_id": 0}
+{"abstract_id": "26017129", "label": "objective", "text": "To describe our trial statistical analysis plan ( SAP ) .", "sentence_id": 1}
+{"abstract_id": "26017129", "label": "methods", "text": "This is an ongoing trial conducted in two phases .", "sentence_id": 2}
+{"abstract_id": "26017129", "label": "methods", "text": "In the preparatory observational phase , we collect three sets of baseline data : ICU characteristics ; patient characteristics , processes of care and outcomes ; and completed safety attitudes questionnaires ( SAQs ) .", "sentence_id": 3}
+{"abstract_id": "26017129", "label": "methods", "text": "In the randomised phase , ICUs are assigned to the experimental or control arms and we collect patient data and repeat the SAQ .", "sentence_id": 4}
+{"abstract_id": "26017129", "label": "results", "text": "Our SAP includes the prespecified model for the primary and secondary outcome analyses , which account for the cluster-randomised design and availability of baseline data .", "sentence_id": 5}
+{"abstract_id": "26017129", "label": "results", "text": "We also detail the multiple mediation models that we will use to assess our secondary hypothesis ( that the effect of the intervention on inhospital mortality is mediated not only through care processes targeted by the checklist , but also through changes in safety culture ) .", "sentence_id": 6}
+{"abstract_id": "26017129", "label": "results", "text": "We describe our approach to sensitivity and subgroup analyses and missing data .", "sentence_id": 7}
+{"abstract_id": "26017129", "label": "conclusions", "text": "We report our SAP before closing our study database and starting analysis .", "sentence_id": 8}
+{"abstract_id": "26017129", "label": "conclusions", "text": "We anticipate that this should prevent analysis bias and enhance the utility of results .", "sentence_id": 9}
+{"abstract_id": "25240700", "label": "background", "text": "The aim of this study is to investigate if therapeutic weight loss reduces P wave dispersion .", "sentence_id": 0}
+{"abstract_id": "25240700", "label": "methods", "text": "@ obese patients ( @ males and @ females ) , part of a randomized clinical trial , were examined over a @ month period .", "sentence_id": 1}
+{"abstract_id": "25240700", "label": "methods", "text": "They were treated with a diet , aiming at @ % weight loss at the @th month .", "sentence_id": 2}
+{"abstract_id": "25240700", "label": "methods", "text": "After physical examination , they underwent laboratory tests , bioelectrical impedance analysis and a electrocardiogram ( ECG ) .", "sentence_id": 3}
+{"abstract_id": "25240700", "label": "methods", "text": "ECGs were transferred to a personal computer via a scanner and then magnified @ times .", "sentence_id": 4}
+{"abstract_id": "25240700", "label": "methods", "text": "We examined at baseline and at the @th month , maximum and minimum P-wave duration , P-wave dispersion and heart rate .", "sentence_id": 5}
+{"abstract_id": "25240700", "label": "results", "text": "Comparing responders ( patients who lost @ % of weight at t@ ) and not responders ( who lost less than @ % ) , responders showed a significant reduction of P wave dispersion value ( -@ -LSB- SD : @ -RSB- mm equal to -@ -LSB- SD : @ -RSB- % p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25240700", "label": "results", "text": "All responders present a reduction of P wave dispersion , while for not-responders this is no longer evident .", "sentence_id": 7}
+{"abstract_id": "25240700", "label": "results", "text": "Finally , a good degree of correlation ( r = @ ) between P wave dispersion difference and the decrease of weight was noticed .", "sentence_id": 8}
+{"abstract_id": "25240700", "label": "results", "text": "Females have a better response in P dispersion reduction strictly connected with their weight loss with a good correlation , ( r = @ , p = @ ) , versus a moderate correlation evidenced in males ( r = @ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25240700", "label": "conclusions", "text": "P wave duration and dispersion are significantly reduced in patients who lost more than @ % of weight and this decrease is highly related to the extent of weight loss .", "sentence_id": 10}
+{"abstract_id": "24342196", "label": "objective", "text": "To evaluate the efficacy and safety of iron protein succinylate ( IPS ) oral solution in preventing and treating anemia of prematurity ( AOP ) .", "sentence_id": 0}
+{"abstract_id": "24342196", "label": "methods", "text": "Sixty premature infants less than @ weeks of gestation were randomly divided into IPS ( n = @ ) and polysaccharide iron complex ( PIC ) groups ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24342196", "label": "methods", "text": "Treatment began at two weeks after birth .", "sentence_id": 2}
+{"abstract_id": "24342196", "label": "methods", "text": "The infants received IPS or PIC in addition to recombinant human erythropoietin .", "sentence_id": 3}
+{"abstract_id": "24342196", "label": "methods", "text": "On days @ , @ , @ , and @ after treatment , hemoglobin ( Hb ) , red blood cell count ( RBC ) , hematocrit ( HCT ) , percentage of reticulocytes , serum iron , and serum ferritin were determined .", "sentence_id": 4}
+{"abstract_id": "24342196", "label": "methods", "text": "Liver and renal functions were evaluated before and after treatment .", "sentence_id": 5}
+{"abstract_id": "24342196", "label": "results", "text": "There were significant differences in the changing trends of RBC and HCT between the two groups ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24342196", "label": "results", "text": "In the IPS group , RBC and HCT gradually decreased after birth , but began to rise gradually on days @ and @ of treatment ; in the PIC group , RBC and HCT kept decreasing from birth to day @ of treatment .", "sentence_id": 7}
+{"abstract_id": "24342196", "label": "results", "text": "On day @ of treatment , the IPS group had significantly higher levels of Hb , RBC , HCT , serum iron , and serum ferritin than the PIC group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24342196", "label": "results", "text": "No notable adverse events occurred in either group .", "sentence_id": 9}
+{"abstract_id": "24342196", "label": "conclusions", "text": "IPS oral solution has good efficacy and tolerability in preventing and treating AOP .", "sentence_id": 10}
+{"abstract_id": "25450242", "label": "objective", "text": "To compare the features of capsulotomy obtained during femtosecond laser-assisted cataract surgery with those of continuous curvilinear capsulorhexis ( CCC ) obtained using a standard manual technique .", "sentence_id": 0}
+{"abstract_id": "25450242", "label": "methods", "text": "Ophthalmology Clinic , Department of Medicine and Science of Ageing , University G. D'Annunzio Chieti-Pescara , Chieti , Italy .", "sentence_id": 1}
+{"abstract_id": "25450242", "label": "methods", "text": "Prospective randomized clinical study .", "sentence_id": 2}
+{"abstract_id": "25450242", "label": "methods", "text": "Candidates for cataract extraction were randomized into @ of @ groups as follows : Lensx femtosecond laser-assisted cataract surgery capsulotomy ( laser group @ ) , Lensar femtosecond laser-assisted cataract surgery capsulotomy ( laser group @ ) , and manual CCC ( manual group ) .", "sentence_id": 3}
+{"abstract_id": "25450242", "label": "results", "text": "Each group comprised @ eyes ( @ patients ) .", "sentence_id": 4}
+{"abstract_id": "25450242", "label": "results", "text": "The capsulotomies in laser group @ and laser group @ showed significantly better circularity than the manual CCCs at @ days ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25450242", "label": "results", "text": "There was a significant correlation between the intended versus achieved capsulotomy size in the @ laser groups .", "sentence_id": 6}
+{"abstract_id": "25450242", "label": "results", "text": "Both laser groups had better intraocular lens ( IOL ) centration than the manual group at all timepoints ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25450242", "label": "results", "text": "Between-group differences in uncorrected and corrected distance visual acuities were not statistically significant .", "sentence_id": 8}
+{"abstract_id": "25450242", "label": "results", "text": "The residual spherical equivalent and mean absolute error were statistically significantly smaller in the @ laser groups than in the manual group ( P = @ ) and increased significantly over time in all the groups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25450242", "label": "conclusions", "text": "Femtosecond laser capsulotomies showed better circularity with more predictable size than manual CCCs .", "sentence_id": 10}
+{"abstract_id": "25450242", "label": "conclusions", "text": "In addition , IOL centration was better immediately after surgery and over time with better refractive results in the @ laser groups .", "sentence_id": 11}
+{"abstract_id": "25052076", "label": "objective", "text": "To evaluate the effect of automated tube voltage selection on radiation dose and image quality at cardiovascular CT angiography ( CTA ) .", "sentence_id": 0}
+{"abstract_id": "25052076", "label": "methods", "text": "We retrospectively analysed paired studies in @ patients ( @ male , @ years ) , who had undergone CTA acquisitions of the heart or aorta both before and after the implementation of an automated x-ray tube voltage selection algorithm ( ATVS ) .", "sentence_id": 1}
+{"abstract_id": "25052076", "label": "methods", "text": "All other parameters were kept identical between the two acquisitions .", "sentence_id": 2}
+{"abstract_id": "25052076", "label": "methods", "text": "Subjective image quality ( IQ ) was rated and objective IQ was measured by image noise , signal-to-noise ratio ( SNR ) , contrast-to-noise ratio ( CNR ) and figure of merit ( FOM ) .", "sentence_id": 3}
+{"abstract_id": "25052076", "label": "methods", "text": "Image quality parameters and effective dose were compared between acquisitions .", "sentence_id": 4}
+{"abstract_id": "25052076", "label": "results", "text": "Overall subjective image quality improved with the percentage of cases scored as adequate or higher increasing from @ % to @ % after implementation of ATVS ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25052076", "label": "results", "text": "SNR ( @ , @ , P = @ ) , CNR ( @ , @ , P = @ ) , and FOM ( @ , @ , P < @ ) were significantly higher after implementation of ATVS .", "sentence_id": 6}
+{"abstract_id": "25052076", "label": "results", "text": "Mean image noise ( @ HU , @ HU , P = @ ) and mean effective dose ( @ mSv , @ mSv , P = @ ) were significantly lower after implementation of ATVS .", "sentence_id": 7}
+{"abstract_id": "25052076", "label": "conclusions", "text": "Automated tube voltage selection can operator-independently optimize cardiovascular CTA image acquisition parameters with improved image quality at reduced dose .", "sentence_id": 8}
+{"abstract_id": "25052076", "label": "conclusions", "text": "Automatic tube voltage selection optimizes tube voltage for each individual patient .", "sentence_id": 9}
+{"abstract_id": "25052076", "label": "conclusions", "text": "In this population , overall radiation dose decreased while image quality improved .", "sentence_id": 10}
+{"abstract_id": "25052076", "label": "conclusions", "text": "This tool may become valuable for improving dose/quality ratio .", "sentence_id": 11}
+{"abstract_id": "24841163", "label": "background", "text": "Inhaled corticosteroids ( ICSs ) are widely used in asthma control .", "sentence_id": 0}
+{"abstract_id": "24841163", "label": "background", "text": "Ciclesonide ( CIC ) is an ICS with on-site lung activation for potent anti-inflammatory activity .", "sentence_id": 1}
+{"abstract_id": "24841163", "label": "objective", "text": "This study aimed to compare the clinical benefit of CIC with budesonide ( BUD ) in step-down therapy .", "sentence_id": 2}
+{"abstract_id": "24841163", "label": "methods", "text": "A total of @ patients with mild-to-moderate asthma well controlled by a combination of ICS and long-acting @-agonist were randomised to receive either CIC @g ( n = @ ) once daily or @ inhalations of BUD @g ( n = @ ) twice daily for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24841163", "label": "methods", "text": "The forced expiratory volume in @s ( FEV@ ) , maximum mid-expiratory flow ( MMEF ) and asthma control test ( ACT ) scores were measured .", "sentence_id": 4}
+{"abstract_id": "24841163", "label": "methods", "text": "Ranked stratification of patients and physicians was assessed .", "sentence_id": 5}
+{"abstract_id": "24841163", "label": "results", "text": "Drug adherence was significantly higher in the CIC group than in the BUD group ( @ % vs. @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24841163", "label": "results", "text": "The FEV@ and MMEF remained stable throughout the @-week CIC treatment .", "sentence_id": 7}
+{"abstract_id": "24841163", "label": "results", "text": "In the BUD group , FEV@ significantly decreased at weeks @ and @ .", "sentence_id": 8}
+{"abstract_id": "24841163", "label": "results", "text": "MMEF had a higher value in the CIC group than in the BUD group .", "sentence_id": 9}
+{"abstract_id": "24841163", "label": "results", "text": "Both patients and physicians ranked CIC over BUD .", "sentence_id": 10}
+{"abstract_id": "24841163", "label": "conclusions", "text": "CIC is more effective and has better drug adherence than BUD as step-down treatment when asthma is well controlled by combination therapy .", "sentence_id": 11}
+{"abstract_id": "25240140", "label": "background", "text": "The efficacy of psychodynamic therapy ( PDT ) for depression is debated due to a paucity of high-quality studies .", "sentence_id": 0}
+{"abstract_id": "25240140", "label": "background", "text": "We compared short psychodynamic supportive psychotherapy ( SPSP ) to cognitive behavioral therapy ( CBT ) in a randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "25240140", "label": "background", "text": "We used therapist-rated outcomes to examine how the course of change during treatment could be best represented and to compare treatment efficacy , hypothesizing non-significant differences .", "sentence_id": 2}
+{"abstract_id": "25240140", "label": "methods", "text": "Three hundred and forty-one adults meeting DSM-IV criteria for a depressive episode and with Hamilton Depression Rating Scale ( HAM-D ) scores @ were randomized to @ sessions of individual manualized CBT or SPSP .", "sentence_id": 3}
+{"abstract_id": "25240140", "label": "methods", "text": "Severely depressed patients ( HAM-D > @ ) received additional antidepressant medication .", "sentence_id": 4}
+{"abstract_id": "25240140", "label": "methods", "text": "After each session , therapists rated the Clinical Global Impression Scale subscales ` Severity of Illness ' ( CGI-S ) and ` Global Improvement ' ( CGI-I ) , and the DSM-IV Axis V Global Assessment of Functioning Scale ( GAF ) .", "sentence_id": 5}
+{"abstract_id": "25240140", "label": "methods", "text": "We fitted growth curves using mixed model analyses with intention-to-treat samples .", "sentence_id": 6}
+{"abstract_id": "25240140", "label": "results", "text": "CGI-S and GAF scores during treatment were best represented by a linear symptom decrease .", "sentence_id": 7}
+{"abstract_id": "25240140", "label": "results", "text": "CGI-I scores were best represented by an S-shaped curve with relative more improvement in the first and last phases than in the middle phase of treatment .", "sentence_id": 8}
+{"abstract_id": "25240140", "label": "results", "text": "No significant post-treatment treatment differences were found .", "sentence_id": 9}
+{"abstract_id": "25240140", "label": "results", "text": "A non-significant trend for a treatment effect on CGI-S scores vanished when controlling for therapist gender and profession .", "sentence_id": 10}
+{"abstract_id": "25240140", "label": "conclusions", "text": "Therapists were not specifically trained for CGI and GAF assessments .", "sentence_id": 11}
+{"abstract_id": "25240140", "label": "conclusions", "text": "These findings add to the evidence-base of PDT for depression .", "sentence_id": 12}
+{"abstract_id": "25240140", "label": "conclusions", "text": "Therapist characteristics and differences between severity and improvement measures might influence ratings and need to be taken into account when using therapist-rated outcome measures .", "sentence_id": 13}
+{"abstract_id": "24809759", "label": "objective", "text": "To compare asthma control assessment using the Asthma APGAR system , a tool developed by primary care clinicians , in a multicenter primary care sample with the Asthma Control Test ( ACT ) / Childhood Asthma Control Test ( CACT ) , a tool developed by asthma specialists .", "sentence_id": 0}
+{"abstract_id": "24809759", "label": "methods", "text": "This is a substudy of a multicenter , randomized , controlled pragmatic trial that tests the effectiveness of the Asthma APGAR system in primary care practices .", "sentence_id": 1}
+{"abstract_id": "24809759", "label": "methods", "text": "As part of the study , enrolled patients completed both the ACT/CACT and the Asthma APGAR system between March @ , @ , and December @ , @ .", "sentence_id": 2}
+{"abstract_id": "24809759", "label": "methods", "text": "Kappa and McNemar statistics were used to compare the results of questionnaires .", "sentence_id": 3}
+{"abstract_id": "24809759", "label": "results", "text": "Of the @ patients in our sample , @ ( @ % ) were classified as not controlled by the ACT/CACT or the Asthma APGAR system .", "sentence_id": 4}
+{"abstract_id": "24809759", "label": "results", "text": "The overall agreement was @ % , with a kappa value of @ ( substantial agreement ) and a McNemar test P value of @ ( suggesting no significant difference in the direction of disagreement ) .", "sentence_id": 5}
+{"abstract_id": "24809759", "label": "results", "text": "Of those with poor control as defined by the Asthma APGAR system , @ % ( @ ) had no controller medications and @ % ( @ ) were seldom or sometimes able to avoid identified triggers for their asthma .", "sentence_id": 6}
+{"abstract_id": "24809759", "label": "results", "text": "Of those who stated that they had been prescribed controller medications , @ of @ ( @ % ) stated that they did not use the controller medication on a daily basis .", "sentence_id": 7}
+{"abstract_id": "24809759", "label": "conclusions", "text": "The Asthma APGAR system and the ACT/CACT similarly assess asthma control in a multicenter primary care-based sample .", "sentence_id": 8}
+{"abstract_id": "24809759", "label": "conclusions", "text": "The Asthma APGAR system identified an `` actionable item '' in more than @ % ( @ ) of the individuals with poor asthma control , thus linking an assessment of poor asthma control with a management strategy .", "sentence_id": 9}
+{"abstract_id": "25791707", "label": "objective", "text": "To evaluate the applicability of magnetic resonance imaging ( MRI ) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment .", "sentence_id": 0}
+{"abstract_id": "25791707", "label": "methods", "text": "Prospective , randomized , controlled , double-blind study .", "sentence_id": 1}
+{"abstract_id": "25791707", "label": "methods", "text": "One single tertiary care institution in a large , cosmopolitan city .", "sentence_id": 2}
+{"abstract_id": "25791707", "label": "methods", "text": "Twenty-six patients ( n = @ ears ) with clinical , audiometric , and tomographic diagnosis of otosclerosis were enrolled .", "sentence_id": 3}
+{"abstract_id": "25791707", "label": "methods", "text": "If computed tomography ( CT ) demonstrated active lesions , these patients underwent MRI to detect otospongiotic foci , seen as areas of gadolinium enhancement .", "sentence_id": 4}
+{"abstract_id": "25791707", "label": "methods", "text": "Patients were divided into @ groups and received treatment with placebo , sodium alendronate , or sodium fluoride for @ months .", "sentence_id": 5}
+{"abstract_id": "25791707", "label": "methods", "text": "After this period , clinical and audiometric evaluations and a second MRI were performed .", "sentence_id": 6}
+{"abstract_id": "25791707", "label": "methods", "text": "Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective ( visual ) and objective ( using specific eFilm Workstation software ) manner .", "sentence_id": 7}
+{"abstract_id": "25791707", "label": "results", "text": "Otospongiosis was most predominantly identified in the region anterior to the oval window , and this site was reliable for comparing pre - and posttreatment scans .", "sentence_id": 8}
+{"abstract_id": "25791707", "label": "results", "text": "The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesions , more relevant in the alendronate group .", "sentence_id": 9}
+{"abstract_id": "25791707", "label": "results", "text": "These findings were statistically significant for both subjective and objective MRI evaluations .", "sentence_id": 10}
+{"abstract_id": "25791707", "label": "conclusions", "text": "MRI shows higher sensitivity than clinical or audiometric assessment for detecting reduction in activity of otospongiosis .", "sentence_id": 11}
+{"abstract_id": "25791707", "label": "conclusions", "text": "The objective MRI evaluation based on software analysis was the most accurate method of monitoring clinical treatment response in otospongiosis .", "sentence_id": 12}
+{"abstract_id": "24462183", "label": "background", "text": "The PLATINUM randomized trial enrolled @ patients treated with either the platinum chromium PROMUS Element everolimus-eluting stent ( PtCr-EES ; Boston Scientific , Natick , MA , USA ) or the predicate cobalt chromium PROMUS/XIENCE V EES ( CoCr-EES ; manufactured as XIENCE V by Abbott Vascular , Santa Clara , CA , USA also distributed as PROMUS by Boston Scientific ) , including @ patients from Japanese sites .", "sentence_id": 0}
+{"abstract_id": "24462183", "label": "background", "text": "This substudy examines @-year outcomes in the Japanese and non-Japanese cohorts .", "sentence_id": 1}
+{"abstract_id": "24462183", "label": "methods", "text": "Patients with @ or @ de novo native coronary artery lesions ( baseline vessel diameter @ mm to @ mm and length @mm ) were randomized @:@ to PtCr-EES ( N = @ patients in Japan ) versus CoCr-EES ( N = @ patients in Japan ) .", "sentence_id": 2}
+{"abstract_id": "24462183", "label": "results", "text": "Several significant differences were noted in baseline demographics , lesion characteristics , and procedural technique between Japanese and non-Japanese patients , including longer fluoroscopy time , less use of contrast , and greater post-dilatation usage and maximum pressure in Japan .", "sentence_id": 3}
+{"abstract_id": "24462183", "label": "results", "text": "Dual antiplatelet usage at @ years was also higher in Japan .", "sentence_id": 4}
+{"abstract_id": "24462183", "label": "results", "text": "Despite these differences , the @-year rates of target lesion failure were comparable in patients treated with PtCr-EES and CoCr-EES both in Japan ( @ % vs @ % respectively , p = @ ) and outside Japan ( @ % vs @ % respectively , p = @ ; p for interaction = @ ) .", "sentence_id": 5}
+{"abstract_id": "24462183", "label": "conclusions", "text": "This PLATINUM study subanalysis suggests that the PtCr-EES and CoCr-EES provide comparable safety and efficacy in both Japanese and non-Japanese patients .", "sentence_id": 6}
+{"abstract_id": "24350416", "label": "background", "text": "Postoperative sore throat ( POST ) is a frequent consequence following ETT intubation , which may negatively affect the postoperative course and patient satisfaction .", "sentence_id": 0}
+{"abstract_id": "24350416", "label": "background", "text": "Benzydamine hydrochloride is a topically-applied non-steroidal anti-inflammatory drug ( NSAID ) .", "sentence_id": 1}
+{"abstract_id": "24350416", "label": "background", "text": "The authors evaluated the analgesic effect of benzydamine hydrochloride dripping on the ETT cuff on POST .", "sentence_id": 2}
+{"abstract_id": "24350416", "label": "methods", "text": "Eighty-six patients participated in this randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "24350416", "label": "methods", "text": "They were assigned into either the benzydamine hydrochloride or the control group .", "sentence_id": 4}
+{"abstract_id": "24350416", "label": "methods", "text": "The whole ETT cuff was dripped either with @ ml ( @ mg ) of benzydamine hydrochloride or nothing five minutes prior to anesthesia induction .", "sentence_id": 5}
+{"abstract_id": "24350416", "label": "methods", "text": "The incidence and severity of POST at @ , @ , @ , @ , @ and @ hours postoperatively were assessed .", "sentence_id": 6}
+{"abstract_id": "24350416", "label": "methods", "text": "The potential adverse effects of benzydamine hydrochloride ( throat numbness throat burning sensation , dry mouth , and thirst ) were also evaluated .", "sentence_id": 7}
+{"abstract_id": "24350416", "label": "results", "text": "Twenty-five patients ( @ % ) in each group had POST ( p-value = @ ) .", "sentence_id": 8}
+{"abstract_id": "24350416", "label": "results", "text": "The severity of POST ( calculated from affected patients ) in both groups at different time points was not significantly different .", "sentence_id": 9}
+{"abstract_id": "24350416", "label": "results", "text": "Patients in the benzydamine hydrochloride group did not have a higher incidence of adverse effects .", "sentence_id": 10}
+{"abstract_id": "24350416", "label": "conclusions", "text": "We found that dripping benzydamine hydrochloride on the ETT cuff neither reduced the incidence of POST nor increased the incidence of adverse effects in comparison with no intervention .", "sentence_id": 11}
+{"abstract_id": "24788217", "label": "background", "text": "Inflammatory bowel diseases impose on patients a broad spectrum of somatic and psychosocial burden .", "sentence_id": 0}
+{"abstract_id": "24788217", "label": "background", "text": "We hypothesized that patients ' self-responsibility in planning and initiating adequate usually multimodal health care can be supported by self-assessment and proactive information , thus improving health-related quality of life and social participation .", "sentence_id": 1}
+{"abstract_id": "24788217", "label": "methods", "text": "We conducted a randomized controlled trial among a random sample of adult members of a German statutory health insurance with Crohn 's disease or ulcerative colitis with at least @ inflammatory bowel diseases-related hospital stay or sick leave in @ or @ .", "sentence_id": 2}
+{"abstract_id": "24788217", "label": "methods", "text": "Five hundred fourteen patients completed a postal screening questionnaire inquiring about @ problems .", "sentence_id": 3}
+{"abstract_id": "24788217", "label": "methods", "text": "The intervention group ( IG ) received an automated data analysis with individualized written advice on appropriate health services , and the control group received usual care .", "sentence_id": 4}
+{"abstract_id": "24788217", "label": "methods", "text": "Main outcomes were health-related quality of life and social participation .", "sentence_id": 5}
+{"abstract_id": "24788217", "label": "methods", "text": "Secondary outcomes included health care utilization , number of screened problems , and self-management skills .", "sentence_id": 6}
+{"abstract_id": "24788217", "label": "results", "text": "After @ months , small beneficial effects were seen for all primary outcomes in the IG : EuroQol visual analog scale score ( difference between IG and control group : @ ; @ % confidence interval , @-@ @ ; P = @ ) , index for measuring participation restriction ( IMET ) score ( difference between IG and control group : @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24788217", "label": "results", "text": "The number of disability days improved only in the IG .", "sentence_id": 8}
+{"abstract_id": "24788217", "label": "results", "text": "The IG reported significantly fewer outpatient visits , fewer disease-related problems , and improved self-management skills ( health education impact questionnaire scores ) with no increase in disease activity , hospital stays , or consultations with allied health professionals .", "sentence_id": 9}
+{"abstract_id": "24788217", "label": "conclusions", "text": "Our activation and information procedure is effective and beneficial .", "sentence_id": 10}
+{"abstract_id": "24788217", "label": "conclusions", "text": "Further studies might show its usefulness in comprehensive management of patients with inflammatory bowel diseases .", "sentence_id": 11}
+{"abstract_id": "24225216", "label": "objective", "text": "To investigate the significance of dynamic monitoring of procalcitonin ( PCT ) in guiding the use of antibiotics for treating patients with sepsis in intensive care unit ( ICU ) .", "sentence_id": 0}
+{"abstract_id": "24225216", "label": "methods", "text": "Eighty-two patients with sepsis from January @ to June @ hospitalized in ICU of First Hospital of Jilin University were enrolled , and they were randomly divided into regular antibiotic therapy group ( RAT group , n = @ ) and PCT monitoring in guiding the use of antibiotics group ( PCT group , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24225216", "label": "methods", "text": "Patients in RAT group were treated according to principle of antibiotics usage , while in PCT group patients ' PCT value was observed everyday .", "sentence_id": 2}
+{"abstract_id": "24225216", "label": "methods", "text": "When no active symptoms of infection were shown , and acute physiology and chronic health evaluation II ( APACHEII ) scores declined , PCT value decreased over @ % or PCT value lower than @ g/L time point were selected as drug withdrawal indication .", "sentence_id": 3}
+{"abstract_id": "24225216", "label": "methods", "text": "The general status of the patient , antimicrobial drug use time , and prognosis were compared between the two groups , and Kaplan-Meier method was used for survival curve analysis .", "sentence_id": 4}
+{"abstract_id": "24225216", "label": "methods", "text": "Variance analysis was used for repeating measurement to observe dynamic serum PCT level of the two groups of patients for survival and death during @ days .", "sentence_id": 5}
+{"abstract_id": "24225216", "label": "results", "text": "Mann-Whitney U test or ( @ ) test showed that there were no statistical significance in age , gender , APACHEII score , blood culture positive rate , sputum culture positive rate , cardiac insufficiency , renal failure , respiratory failure , and ventilator and hemofiltration usage ( all P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24225216", "label": "results", "text": "Log Rank test results showed that the time of antimicrobial drug usage was significantly reduced in PCT group than that in RAT group -LSB- days : @ , @ % confidence interval ( @ % CI @-@ @ ) vs. @ ( @ % CI @-@ @ ) , P = @ -RSB- .", "sentence_id": 7}
+{"abstract_id": "24225216", "label": "results", "text": "Kaplan-Meier univariate survival curves showed that the speed of curve declination in PCT group was faster significantly than that in RAT group , suggesting that the time of using antimicrobial drug was shortened .", "sentence_id": 8}
+{"abstract_id": "24225216", "label": "results", "text": "There was no significant difference in length of hospital stay , ICU stay time , number of death in @ days , number of cases of recurrence in @ days and clinical cure rate between two groups ( all P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24225216", "label": "results", "text": "PCT level in non-survivors in both groups was significantly higher than that in the survivors , exceeding more than @ g/L in the early and late stages of treatment .", "sentence_id": 10}
+{"abstract_id": "24225216", "label": "conclusions", "text": "Dynamic monitoring of PCT can effectively reduce antimicrobial drug use in ICU patients with sepsis , but there is no significant difference in patients ' prognosis .", "sentence_id": 11}
+{"abstract_id": "24524806", "label": "objective", "text": "The PDY@ study evaluated efficacy , safety and pharmacodynamics of lixisenatide in Japanese and Caucasian patients with type @ diabetes mellitus ( T@DM ) insufficiently controlled with sulphonylureas with/without metformin .", "sentence_id": 0}
+{"abstract_id": "24524806", "label": "methods", "text": "This randomized , double-blind , placebo-controlled trial comprised a single-dose assessment of lixisenatide @ and @g , and a @ - to @-week repeated dose-escalation assessment of lixisenatide @ to @g once ( QD ) or twice daily ( BID ) .", "sentence_id": 1}
+{"abstract_id": "24524806", "label": "methods", "text": "The primary endpoint was change in postprandial plasma glucose ( PPG ) area under the curve ( AUC ) -LSB- @:@ -@:@ h -RSB- after a standardized breakfast at the highest tolerated lixisenatide dose .", "sentence_id": 2}
+{"abstract_id": "24524806", "label": "methods", "text": "Change from baseline in glycated haemoglobin ( HbA@c ) , @-h PPG and fasting plasma glucose ( FPG ) were assessed , as were adverse events .", "sentence_id": 3}
+{"abstract_id": "24524806", "label": "results", "text": "Change from baseline in PPG AUC -LSB- @:@ -@:@ h -RSB- with lixisenatide QD and BID was significantly greater than placebo ( p < @ for all study populations ) , with particularly prominent effects in Japanese patients .", "sentence_id": 4}
+{"abstract_id": "24524806", "label": "results", "text": "Greater reductions in PPG AUC -LSB- @:@ -@:@ h -RSB- were seen with lixisenatide QD versus BID , while the totality of evidence suggested that the lixisenatide @g dose was optimal .", "sentence_id": 5}
+{"abstract_id": "24524806", "label": "results", "text": "In the overall population , changes from baseline for @-h PPG , HbA@c and FPG were significant with lixisenatide QD and BID versus placebo ( p < @ for all ) .", "sentence_id": 6}
+{"abstract_id": "24524806", "label": "results", "text": "Lixisenatide was well tolerated .", "sentence_id": 7}
+{"abstract_id": "24524806", "label": "conclusions", "text": "Lixisenatide significantly reduced PPG AUC -LSB- @:@ -@:@ h -RSB- versus placebo at the highest well-tolerated dose in patients with T@DM treated with sulphonylureas with/without metformin and had a good safety and tolerability profile .", "sentence_id": 8}
+{"abstract_id": "24524806", "label": "conclusions", "text": "Japanese patients experienced particular benefits with lixisenatide in terms of reductions in PPG excursions .", "sentence_id": 9}
+{"abstract_id": "25867812", "label": "background", "text": "Relatively low radioiodine uptake ( RAIU ) represents a common obstacle for radioiodine ( ( @ ) I ) therapy in patients with multinodular goiter complicated by hyperthyroidism .", "sentence_id": 0}
+{"abstract_id": "25867812", "label": "objective", "text": "To evaluate whether thiamazole ( MTZ ) pretreatment can increase ( @ ) I therapeutic efficacy .", "sentence_id": 1}
+{"abstract_id": "25867812", "label": "methods", "text": "Twenty-two patients with multinodular goiter , subclinical hyperthyroidism , and RAIU < @ % were randomized to receive either a low-iodine diet ( LID ; n = @ ) or MTZ @ mg/d ( n = @ ) for @ days .", "sentence_id": 2}
+{"abstract_id": "25867812", "label": "methods", "text": "Thyroid function and @-hour RAIU were measured before and after treatment .", "sentence_id": 3}
+{"abstract_id": "25867812", "label": "methods", "text": "Thyroid volume was evaluated by either magnetic resonance imaging or single photon emission computed tomography .", "sentence_id": 4}
+{"abstract_id": "25867812", "label": "results", "text": "Mean @-hour RAIU increased significantly from @ @ % to @ @ % in the MTZ group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25867812", "label": "results", "text": "Consequently , there was a @ % decrease in the calculated median therapeutic ( @ ) I activity after MTZ ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25867812", "label": "results", "text": "No significant changes in @-hour RAIU were observed after diet .", "sentence_id": 7}
+{"abstract_id": "25867812", "label": "results", "text": "In the MTZ group , median serum TSH levels increased significantly by @ % and mean serum free T@ and free T@ concentrations decreased by @ % and @ % , respectively , whereas no changes in thyroid function were observed in the LID group .", "sentence_id": 8}
+{"abstract_id": "25867812", "label": "results", "text": "Thyroid volume did not significantly change in either of the two groups .", "sentence_id": 9}
+{"abstract_id": "25867812", "label": "results", "text": "At @ months after radioiodine treatment , median serum TSH was within the normal range in both groups .", "sentence_id": 10}
+{"abstract_id": "25867812", "label": "conclusions", "text": "MTZ treatment before ( @ ) I therapy resulted in an average @-fold increase in thyroid RAIU and enhanced the efficiency of radioiodine therapy assessed at @ months .", "sentence_id": 11}
+{"abstract_id": "25867812", "label": "conclusions", "text": "MTZ pretreatment is therefore a safe , easily accessible alternative to recombinant human TSH stimulation and a more effective option than LID .", "sentence_id": 12}
+{"abstract_id": "25898472", "label": "objective", "text": "To evaluate pregnancy rates based on the route of progesterone replacement in frozen embryo transfer ( FET ) cycles .", "sentence_id": 0}
+{"abstract_id": "25898472", "label": "methods", "text": "A randomized controlled trial and retrospective analysis .", "sentence_id": 1}
+{"abstract_id": "25898472", "label": "methods", "text": "In the randomized group @ FET cycles were randomized .", "sentence_id": 2}
+{"abstract_id": "25898472", "label": "methods", "text": "In the retrospective group @ FET cycles were reviewed .", "sentence_id": 3}
+{"abstract_id": "25898472", "label": "methods", "text": "Intramuscular ( IM ) proges-erone in oil @ mg daily or oral micronized progesterone prior to transfer followed by compounded vaginal proges-erone @ mg @ times daily ( OV ) .", "sentence_id": 4}
+{"abstract_id": "25898472", "label": "methods", "text": "The main outcome measure was the clinical pregnancy rate ( CPR ) .", "sentence_id": 5}
+{"abstract_id": "25898472", "label": "results", "text": "Baseline characteristics did not vary be-ween groups in either cohort .", "sentence_id": 6}
+{"abstract_id": "25898472", "label": "results", "text": "In the randomized group there were no significant differences in CPR ( @ % vs. @ % ) or live birth rate ( LBR ) ( @ % vs. @ % ) for IM and OV progesterone replacement , respectively .", "sentence_id": 7}
+{"abstract_id": "25898472", "label": "results", "text": "In the retrospective cohort patients there wore also no significant differences in CPR ( @ % vs. @ % ) or LBR ( @ % vs. @ % ) f or the IM and OVp rogester-ne replacement groups , respectively .", "sentence_id": 8}
+{"abstract_id": "25898472", "label": "conclusions", "text": "This study demonstrates that either OV or IM progesterone is effective for luteal phase support for FETs .", "sentence_id": 9}
+{"abstract_id": "24785925", "label": "background", "text": "Surgically assisted rapid palatal expansion ( SARPE ) is the procedure of choice for treatment of adults with transverse maxillary deficiency greater than @ mm .", "sentence_id": 0}
+{"abstract_id": "24785925", "label": "background", "text": "There is no consensus about the dentoskeletal effect of an orthodontic retainer on the outcome of SARPE .", "sentence_id": 1}
+{"abstract_id": "24785925", "label": "background", "text": "Our objective was to assess the effectiveness of an orthodontic retainer on dentoskeletal stability .", "sentence_id": 2}
+{"abstract_id": "24785925", "label": "methods", "text": "Ninety digitized dental casts of @ adults undergoing SARPE were divided into @ groups-no retention ( n = @ ) and retention ( n = @ ) - and assessed .", "sentence_id": 3}
+{"abstract_id": "24785925", "label": "methods", "text": "The dental casts were obtained at @ checkpoints : ( @ ) @ days on average before SARPE ( preoperatively ) , ( @ ) @ months after expansion , and ( @ ) @ months after expansion was completed .", "sentence_id": 4}
+{"abstract_id": "24785925", "label": "methods", "text": "The retention patients received a transpalatal arch just after expander removal , at checkpoint @ .", "sentence_id": 5}
+{"abstract_id": "24785925", "label": "methods", "text": "The transpalatal arch was kept for @ months after completion of the expansion ( checkpoint @ and end of the study ) .", "sentence_id": 6}
+{"abstract_id": "24785925", "label": "methods", "text": "The dental casts were scanned with a Vivid @i @D laser scanner ( Konica Minolta , Wayne , NJ ) .", "sentence_id": 7}
+{"abstract_id": "24785925", "label": "methods", "text": "The distances measured were premolar and molar intercusp distances , premolar and molar intercervical distances , premolar and molar inter-WALA ( Will Andrews and Lawrence Andrews ) ridge distances , and palate height at the maxillary first molar .", "sentence_id": 8}
+{"abstract_id": "24785925", "label": "results", "text": "The planned maxillary expansion was within the expected amount ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24785925", "label": "results", "text": "Palatal height at the @-month checkpoint decreased by @ mm ( @ % ) ( P < @ ) and again at the @-month checkpoint by @ mm ( @ % ) ( P > @ ) but not significantly in both groups .", "sentence_id": 10}
+{"abstract_id": "24785925", "label": "results", "text": "The premolar intercusp distance had a relapse at checkpoint @ of @ mm ( @ % ) ( P < @ ) in the no-retention group .", "sentence_id": 11}
+{"abstract_id": "24785925", "label": "results", "text": "Both groups had average relapses of @ mm in the premolar intercervical distances , of @ mm in the premolar inter-WALA ridge distances , of @ mm in the molar intercusp distances , of @ mm in the molar intercervical distances , and of @ mm in the molar inter-WALA ridge distances ( P < @ ) at checkpoint @ .", "sentence_id": 12}
+{"abstract_id": "24785925", "label": "conclusions", "text": "The analysis of relapse in both groups suggests that the use of a transpalatal arch as a retaining device does not improve dento-osseous stability .", "sentence_id": 13}
+{"abstract_id": "26066615", "label": "background", "text": "Acellular dermal matrix ( ADM ) has been used for antiadhesion formation along with wound healing in various surgical fields .", "sentence_id": 0}
+{"abstract_id": "26066615", "label": "objective", "text": "The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional , open , total thyroidectomy .", "sentence_id": 1}
+{"abstract_id": "26066615", "label": "methods", "text": "Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study ( ADM implantation ) or control group ( without ADM ) .", "sentence_id": 2}
+{"abstract_id": "26066615", "label": "methods", "text": "Global photographic assessment , Vancouver scar scale ( VSS ) , objective scar assessment , and swallowing impairment index were assessed at baseline , immediately after surgery , and at @ and @ months after surgery .", "sentence_id": 3}
+{"abstract_id": "26066615", "label": "results", "text": "Nineteen control and @ study group participants completed the study .", "sentence_id": 4}
+{"abstract_id": "26066615", "label": "results", "text": "The mean VSS score of the study group was significantly lower than the controls at both @ month ( @ @ vs @ @ , respectively ) and @ months ( @ @ vs @ @ , respectively ) after surgery .", "sentence_id": 5}
+{"abstract_id": "26066615", "label": "results", "text": "Scar quality measures ( mean melanin and erythema indexes ) were significantly lower in the study group compared with controls .", "sentence_id": 6}
+{"abstract_id": "26066615", "label": "results", "text": "Study group participants had significantly lower swallowing impairment scores than controls .", "sentence_id": 7}
+{"abstract_id": "26066615", "label": "results", "text": "The mean postoperative hospitalization of both groups was not significantly different .", "sentence_id": 8}
+{"abstract_id": "26066615", "label": "conclusions", "text": "Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time .", "sentence_id": 9}
+{"abstract_id": "24249049", "label": "background", "text": "Heart failure with preserved ejection fraction ( HFpEF ) is associated with substantial morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "24249049", "label": "background", "text": "Existing data on cardiac structure and function in HFpEF suggest significant heterogeneity in this population .", "sentence_id": 1}
+{"abstract_id": "24249049", "label": "results", "text": "Echocardiograms were obtained from @ patients with HFpEF ( left ventricular ejection fraction @ % ) enrolled in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist ( TOPCAT ) trial before initiation of randomized therapy .", "sentence_id": 2}
+{"abstract_id": "24249049", "label": "results", "text": "Average age was @ years , @ % were women , @ % were of African descent , and comorbidities were highly prevalent .", "sentence_id": 3}
+{"abstract_id": "24249049", "label": "results", "text": "Centralized quantitative analysis in a blinded core laboratory demonstrated a mean left ventricular ejection fraction of @ % , with prevalent concentric left ventricular remodeling ( @ % ) and hypertrophy ( @ % ) , and left atrial enlargement ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "24249049", "label": "results", "text": "Diastolic dysfunction was present in @ % of gradable participants and was significantly associated with greater left ventricular hypertrophy and a higher prevalence of left atrial enlargement .", "sentence_id": 5}
+{"abstract_id": "24249049", "label": "results", "text": "Doppler evidence of pulmonary hypertension was present in @ % .", "sentence_id": 6}
+{"abstract_id": "24249049", "label": "results", "text": "At least @ measure of structural heart disease was present in @ % of patients .", "sentence_id": 7}
+{"abstract_id": "24249049", "label": "conclusions", "text": "Patients enrolled in TOPCAT demonstrated heterogeneous patterns of ventricular remodeling , with high prevalence of structural heart disease , including left ventricular hypertrophy and left atrial enlargement , in addition to pulmonary hypertension , each of which has been associated with adverse outcomes in HFpEF .", "sentence_id": 8}
+{"abstract_id": "24249049", "label": "conclusions", "text": "Diastolic function was normal in approximately one third of gradable participants , highlighting the heterogeneity of the cardiac phenotype in this syndrome .", "sentence_id": 9}
+{"abstract_id": "24249049", "label": "conclusions", "text": "These findings deepen our understanding of the TOPCAT trial population and expand our knowledge of the diversity of the cardiac phenotype in HFpEF .", "sentence_id": 10}
+{"abstract_id": "24286966", "label": "objective", "text": "This study examined the relationships between treatment fidelity and treatment outcomes in a community-based trial of a @-Step Facilitation ( TSF ) intervention .", "sentence_id": 0}
+{"abstract_id": "24286966", "label": "methods", "text": "In a prior multi-site randomized clinical trial , @ participants in @ outpatient drug treatment clinics were assigned to receive the Stimulant Abuser Groups to Engage in @-Step ( STAGE-@ ) intervention .", "sentence_id": 1}
+{"abstract_id": "24286966", "label": "methods", "text": "A secondary analysis reviewed and coded all STAGE-@ sessions for fidelity to the protocol , using the Twelve Step Facilitation Adherence Competence Empathy Scale ( TSF ACES ) .", "sentence_id": 2}
+{"abstract_id": "24286966", "label": "methods", "text": "Linear mixed-effects models tested the relationship between three fidelity measures ( adherence , competence , empathy ) and six treatment outcomes ( number of days of drug use and five Addiction Severity Index ( ASI ) composite scores ) measured at @ months post-baseline .", "sentence_id": 3}
+{"abstract_id": "24286966", "label": "results", "text": "Adherence , competence and empathy were robustly associated with improved employment status at follow up .", "sentence_id": 4}
+{"abstract_id": "24286966", "label": "results", "text": "Empathy was inversely associated with drug use , as was competence in a non-significant trend ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24286966", "label": "results", "text": "Testing individual ASI drug composite score items suggested that greater competence was associated with fewer days of drug use and , at the same time , with an increased sense of being troubled or bothered by drug use .", "sentence_id": 6}
+{"abstract_id": "24286966", "label": "conclusions", "text": "Greater competence and empathy in the delivery of a TSF intervention were associated with better drug use and employment outcomes , while adherence was associated with employment outcomes only .", "sentence_id": 7}
+{"abstract_id": "24286966", "label": "conclusions", "text": "Higher therapist competence was associated with lower self-report drug use , and also associated with greater self-report concern about drug use .", "sentence_id": 8}
+{"abstract_id": "24286966", "label": "conclusions", "text": "The nature of TSF intervention may promote high levels of concern about drug use even when actual use is low .", "sentence_id": 9}
+{"abstract_id": "24799054", "label": "objective", "text": "Clinical activity of chemotherapy plus trastuzumab in HER@ overexpressing advanced breast cancer has been documented .", "sentence_id": 0}
+{"abstract_id": "24799054", "label": "objective", "text": "We report the activity and safety results of biweekly combination of trastuzumab , docetaxel and gemcitabine as first-line therapy in HER@-positive advanced breast cancer .", "sentence_id": 1}
+{"abstract_id": "24799054", "label": "methods", "text": "Patients were biweekly treated with trastuzumab ( @ mg/kg ) , gemcitabine ( @ mg/m ( @ ) ) and docetaxel ( @ mg/m ( @ ) ) .", "sentence_id": 2}
+{"abstract_id": "24799054", "label": "methods", "text": "The primary end point was overall response rate , secondary time to progression , clinical benefit rate ( partial response plus complete response plus stable disease for @ weeks ) and tolerability .", "sentence_id": 3}
+{"abstract_id": "24799054", "label": "results", "text": "A total of @ patients with HER@-positive advanced breast cancer have been enrolled .", "sentence_id": 4}
+{"abstract_id": "24799054", "label": "results", "text": "In total , @ patients responded ( @ % ; @ % CI , @-@ ) , @ achieved complete response ( @ % ; @ % CI : @-@ @ ) , @ achieved partial response ( @ % ; @ % CI : @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "24799054", "label": "results", "text": "The clinical benefit rate was @ % ( @ % CI : @-@ ) .", "sentence_id": 6}
+{"abstract_id": "24799054", "label": "results", "text": "Three patients ( @ % ) experienced progressive disease .", "sentence_id": 7}
+{"abstract_id": "24799054", "label": "results", "text": "The median time to progression was @ months ( @ % CI : @-@ @ ) , the median overall survival was @ months and the @-month survival rate was @ % ( @ % CI : @-@ ) .", "sentence_id": 8}
+{"abstract_id": "24799054", "label": "results", "text": "The worst toxicities were grade @ neutropenia ( @ % ) , thrombocytopenia ( @ % ) and diarrhea ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24799054", "label": "results", "text": "No cardiac toxicity was reported .", "sentence_id": 10}
+{"abstract_id": "24799054", "label": "conclusions", "text": "As first-line therapy , this combination allowed the delivery of polychemotherapy in association to targeted therapy , with clinical activity and mild toxicity .", "sentence_id": 11}
+{"abstract_id": "24799054", "label": "conclusions", "text": "The promising results should be further explored in Phase III randomized clinical trials .", "sentence_id": 12}
+{"abstract_id": "24285491", "label": "objective", "text": "To assess whether in early ( rheumatoid ) arthritis ( RA ) patients , metacarpal bone mineral density ( BMD ) loss after @months predicts radiological progression after @year of antirheumatic treatment .", "sentence_id": 0}
+{"abstract_id": "24285491", "label": "methods", "text": "Metacarpal BMD was measured @ monthly during the first year by digital X-ray radiogrammetry ( DXR-BMD ) in patients participating in the IMPROVED study , a clinical trial in @ patients with recent onset RA ( @ criteria ) or undifferentiated arthritis , treated according to a remission ( disease activity score < @ ) steered strategy .", "sentence_id": 1}
+{"abstract_id": "24285491", "label": "methods", "text": "With Sharp/van der Heijde progression @ points after @year ( yes/no ) as dependent variable , univariate and multivariate logistic regression analyses were performed .", "sentence_id": 2}
+{"abstract_id": "24285491", "label": "results", "text": "Of @ patients with DXR-BMD results and progression scores available , @ ( @ % ) had radiological progression after @year .", "sentence_id": 3}
+{"abstract_id": "24285491", "label": "results", "text": "Independent predictors for radiological progression were presence of baseline erosions ( OR ( @ % CI ) @ ( @ to @ ) ) and early DXR-BMD loss ( OR ( @ % CI ) @ ( @ to @ ) ) .", "sentence_id": 4}
+{"abstract_id": "24285491", "label": "results", "text": "In @ ( @ % ) patients without baseline erosions , early DXR-BMD loss was the only independent predictor of progression ( OR ( @ % CI ) @ ( @ to @ ) ) .", "sentence_id": 5}
+{"abstract_id": "24285491", "label": "conclusions", "text": "In early RA patients , metacarpal BMD loss after @months of treatment is an independent predictor of radiological progression after @year .", "sentence_id": 6}
+{"abstract_id": "24285491", "label": "conclusions", "text": "In patients without baseline erosions , early metacarpal BMD loss is the main predictor of radiological progression .", "sentence_id": 7}
+{"abstract_id": "24969260", "label": "objective", "text": "To compare the effectiveness of two low-intensity approaches for distressed patients with cancer and caregivers who had called cancer helplines seeking support .", "sentence_id": 0}
+{"abstract_id": "24969260", "label": "objective", "text": "Baseline distress was hypothesized as a moderator of intervention effect .", "sentence_id": 1}
+{"abstract_id": "24969260", "label": "methods", "text": "Randomized trial .", "sentence_id": 2}
+{"abstract_id": "24969260", "label": "methods", "text": "Community-based cancer helplines in Queensland and New South Wales , Australia .", "sentence_id": 3}
+{"abstract_id": "24969260", "label": "methods", "text": "@ patients with cancer and @ caregivers .", "sentence_id": 4}
+{"abstract_id": "24969260", "label": "methods", "text": "Participants were randomized to either a single session of nurse-led self-management intervention or a five-session psychologist cognitive behavioral intervention delivered by telephone .", "sentence_id": 5}
+{"abstract_id": "24969260", "label": "methods", "text": "Assessments were undertaken at baseline ( preintervention ) and at @ , @ , and @ months .", "sentence_id": 6}
+{"abstract_id": "24969260", "label": "methods", "text": "Psychological and cancer-specific distress and post-traumatic growth .", "sentence_id": 7}
+{"abstract_id": "24969260", "label": "results", "text": "No significant moderation by baseline cancer-specific distress was noted .", "sentence_id": 8}
+{"abstract_id": "24969260", "label": "results", "text": "For low-education patients , only the psychologist intervention was associated with a significant drop in distress .", "sentence_id": 9}
+{"abstract_id": "24969260", "label": "results", "text": "For all other participants , distress decreased over time in both arms with small to large effect sizes ( Cohen 's ds = @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24969260", "label": "results", "text": "Post-traumatic growth increased over time for all participants ( Cohen 's ds = @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24969260", "label": "conclusions", "text": "Many distressed patients with cancer and their caregivers may benefit significantly from a single session of a nurse psychoeducation intervention that can be delivered remotely by telephone and supported by self-management materials .", "sentence_id": 12}
+{"abstract_id": "24969260", "label": "conclusions", "text": "Research is needed to develop an algorithm that moves beyond the use of distress as the only indicator for referral to specialist psychological services .", "sentence_id": 13}
+{"abstract_id": "24969260", "label": "conclusions", "text": "Survivors and caregivers with low education and low literacy may require more in-depth and targeted support .", "sentence_id": 14}
+{"abstract_id": "24969260", "label": "conclusions", "text": "Brief nurse psychoeducation and stress management for cancer survivors and caregivers should be considered as part of a tiered approach to psychosocial care .", "sentence_id": 15}
+{"abstract_id": "25684224", "label": "objective", "text": "To compare the effectiveness of controlled-released carbamazepine ( CR-CBZ ) to levetiracetam ( LEV ) and to lamotrigine ( LTG ) in elderly patients with newly diagnosed focal epilepsy .", "sentence_id": 0}
+{"abstract_id": "25684224", "label": "methods", "text": "Randomized , double-blind , parallel-group trial conducted between January @ and August @ , in @ ambulatory or hospital sites in Germany , Austria , or Switzerland .", "sentence_id": 1}
+{"abstract_id": "25684224", "label": "methods", "text": "Eligible participants were aged @ , had new-onset epilepsy , had no acute illness as the cause of their seizures , and had no contraindication to the drugs in the trial .", "sentence_id": 2}
+{"abstract_id": "25684224", "label": "methods", "text": "Patients were randomized @:@:@ to CR-CBZ , LTG , or LEV .", "sentence_id": 3}
+{"abstract_id": "25684224", "label": "methods", "text": "Doses were up-titrated for @ weeks and could be maintained or adjusted depending on seizure relapse or tolerability over an additional period of @ weeks .", "sentence_id": 4}
+{"abstract_id": "25684224", "label": "methods", "text": "Primary outcome was the retention to treatment at week @ ; secondary measures related to seizure and adverse event frequency .", "sentence_id": 5}
+{"abstract_id": "25684224", "label": "results", "text": "Of @ randomized patients , @ were included ( CR-CBZ n = @ , LTG n = @ , LEV n = @ ) in the modified intent-to-treat population ( mean age -LSB- range -RSB- @ -LSB- @-@ -RSB- years ) .", "sentence_id": 6}
+{"abstract_id": "25684224", "label": "results", "text": "At week @ , the retention rate for LEV was significantly higher than for CR-CBZ ( @ % vs. @ % , p = @ ) , and similar to LTG ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25684224", "label": "results", "text": "Seizure freedom rates at weeks @ and @ were not different across the groups .", "sentence_id": 8}
+{"abstract_id": "25684224", "label": "results", "text": "Twice as many patients receiving CR-CBZ discontinued due to adverse events or death compared to those in the LEV group ( @ % vs. @ % ; odds ratio @ , @ % confidence interval -LSB- CI -RSB- @-@ @ , p = @ ) , whereas discontinuation was intermediate for LTG ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "25684224", "label": "results", "text": "Median daily doses of completers ( n = @ ) were CR-CBZ @ mg/day ( @-@ @ ) , LTG @ mg/day ( @-@ @ ) , and LEV @ mg/day ( @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25684224", "label": "conclusions", "text": "In the initial monotherapy of focal epilepsy in the elderly , @-year retention to LEV was higher compared to CR-CBZ due to better tolerability .", "sentence_id": 11}
+{"abstract_id": "25684224", "label": "conclusions", "text": "Retention of LTG was intermediate and close to LEV , but did not differ significantly from either comparators .", "sentence_id": 12}
+{"abstract_id": "25684224", "label": "conclusions", "text": "NCT@ , www.clinicaltrials.gov .", "sentence_id": 13}
+{"abstract_id": "25332492", "label": "objective", "text": "To determine whether an evidence-based pediatric outpatient intervention for parents who smoke persisted after initial implementation .", "sentence_id": 0}
+{"abstract_id": "25332492", "label": "methods", "text": "A cluster randomized controlled trial of @ pediatric practices in @ states that received either Clinical and Community Effort Against Secondhand Smoke Exposure ( CEASE ) intervention or usual care .", "sentence_id": 1}
+{"abstract_id": "25332492", "label": "methods", "text": "The intervention provided practices with training to provide evidence-based assistance to parents who smoke .", "sentence_id": 2}
+{"abstract_id": "25332492", "label": "methods", "text": "The primary outcome , assessed by the @-month follow-up telephone survey with parents , was provision of meaningful tobacco control assistance , defined as discussing various strategies to quit smoking , discussing smoking cessation medication , or recommending the use of the state quitline after initial enrollment visit .", "sentence_id": 3}
+{"abstract_id": "25332492", "label": "methods", "text": "We also assessed parental quit rates at @ months , determined by self-report and biochemical verification .", "sentence_id": 4}
+{"abstract_id": "25332492", "label": "results", "text": "Practices ' rates of providing any meaningful tobacco control assistance ( @ % vs @ % ) , discussing various strategies to quit smoking ( @ % vs @ % ) , discussing cessation medication ( @ % vs @ % ) , and recommending the use of the quitline ( @ % vs @ % ) were all significantly higher in the intervention than in the control groups , respectively ( P < @ for each ) , during the @-month postintervention implementation .", "sentence_id": 5}
+{"abstract_id": "25332492", "label": "results", "text": "Receiving any assistance was associated with a cotinine-confirmed quitting adjusted odds ratio of @ ( @ % confidence interval : @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "25332492", "label": "results", "text": "After controlling for demographic and behavioral factors , the adjusted odds ratio for cotinine-confirmed quitting in intervention versus control practices was @ ( @ % confidence interval : @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "25332492", "label": "conclusions", "text": "Intervention practices had higher rates of delivering tobacco control assistance than usual care practices over the @-year follow-up period .", "sentence_id": 8}
+{"abstract_id": "25332492", "label": "conclusions", "text": "Parents who received any assistance were more likely to quit smoking ; however , parents ' likelihood of quitting smoking was not statistically different between the intervention and control groups .", "sentence_id": 9}
+{"abstract_id": "25332492", "label": "conclusions", "text": "Maximizing parental quit rates will require more complete systems-level integration and adjunctive cessation strategies .", "sentence_id": 10}
+{"abstract_id": "25069621", "label": "objective", "text": "To examine the feasibility , acceptability , and initial efficacy of a technology-based weight loss intervention for urban , low-income mothers .", "sentence_id": 0}
+{"abstract_id": "25069621", "label": "methods", "text": "Eighteen obese , ethnic minority , socioeconomically disadvantaged mothers in the first year after childbirth were randomly assigned to either : @ ) technology-based intervention , which included empirically supported behavior-change strategies , daily skills , and self-monitoring text messages with personalized feedback , biweekly counseling calls from a health coach , and access to a Facebook support group , or @ ) usual-care control .", "sentence_id": 1}
+{"abstract_id": "25069621", "label": "results", "text": "After @ weeks of treatment , the technology-based intervention participants had significantly greater weight loss ( -@ @ kg ) than usual care ( @ @ kg ; adjusted mean difference : -@ kg , @ % confidence interval -@ to -@ kg , P = @ ) .", "sentence_id": 2}
+{"abstract_id": "25069621", "label": "results", "text": "One-third of intervention participants ( @ of @ ) and no control participants lost > @ % of their initial body weight at follow up .", "sentence_id": 3}
+{"abstract_id": "25069621", "label": "conclusions", "text": "Results suggest the potential for using technology to deliver a postpartum weight loss intervention among low-income racial/ethnic minorities .", "sentence_id": 4}
+{"abstract_id": "24727325", "label": "objective", "text": "A let-@ microRNA-complementary site ( LCS@ ) polymorphism in the @ ' untranslated region of the KRAS gene has been shown to disrupt let-@ binding and upregulate KRAS expression .", "sentence_id": 0}
+{"abstract_id": "24727325", "label": "objective", "text": "We evaluated the LCS@ genotype and its association with KRAS mutation status , clinicopathologic features , and disease-free survival ( DFS ) in patients with stage III colon cancer who enrolled in a phase III clinical trial ( NCCTG N@ ) .", "sentence_id": 1}
+{"abstract_id": "24727325", "label": "methods", "text": "The LCS@ genotype was assayed by real-time PCR in DNA extracted from whole blood ( n = @,@ ) and compared with paired tumor tissue ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24727325", "label": "methods", "text": "( @ ) and two-sample t tests were used to compare baseline factors and KRAS mutation status between patients defined by LCS@ variant status .", "sentence_id": 3}
+{"abstract_id": "24727325", "label": "methods", "text": "Log-rank tests and multivariate Cox models assessed associations between LCS@ status and DFS , respectively .", "sentence_id": 4}
+{"abstract_id": "24727325", "label": "results", "text": "We identified @ ( @ % ) blood samples and @ ( @ % ) tumor samples heterozygous or homozygous for the LCS@ G-allele , and @,@ of @,@ ( @ % ) blood samples and @ of @ ( @ % ) tumor samples homozygous for the LCS@ T-allele .", "sentence_id": 5}
+{"abstract_id": "24727325", "label": "results", "text": "Genotype results were highly concordant ( @ % ) in cases with paired blood and tumor tissue ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24727325", "label": "results", "text": "G-allele carriers were significantly more frequent in Caucasians versus other races ( ( @ ) test , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24727325", "label": "results", "text": "The LCS@ genotype was not associated with KRAS mutation status , clinicopathologic features ( all P > @ ) , or DFS ( log-rank P = @ ; HR , @ ; @ % confidence interval , @-@ @ ) , even after combining LCS@ genotype with KRAS mutation status .", "sentence_id": 8}
+{"abstract_id": "24727325", "label": "conclusions", "text": "In the largest association study investigating the LCS@ polymorphism in colon cancers , the germline LCS@ genotype was not associated with KRAS mutation status or with clinical outcome in patients with stage III tumors .", "sentence_id": 9}
+{"abstract_id": "24279638", "label": "objective", "text": "To assess whether an interdisciplinary intervention is more effective than usual care for improving the health-related quality of life ( HRQoL ) among patients with fibromyalgia ( FM ) , and to identify variables that were predictors of improvement in HRQoL .", "sentence_id": 0}
+{"abstract_id": "24279638", "label": "methods", "text": "In a randomized controlled clinical trial carried out on an outpatient basis in a hospital pain management unit , @ patients with FM were randomly allocated to an experimental group ( EG ) or a control group ( CG ) .", "sentence_id": 1}
+{"abstract_id": "24279638", "label": "methods", "text": "Participants completed the Fibromyalgia Impact Questionnaire ( FIQ ) at baseline and @months after the intervention .", "sentence_id": 2}
+{"abstract_id": "24279638", "label": "methods", "text": "The EG received an interdisciplinary treatment ( @ sessions for @weeks ) which consisted of coordinated psychological , medical , educational , and physiotherapeutic interventions while the CG received standard-of-care pharmacologic treatment .", "sentence_id": 3}
+{"abstract_id": "24279638", "label": "methods", "text": "Descriptive statistics , ANOVA , Chi square and Fisher tests and generalized linear models were used for data analysis .", "sentence_id": 4}
+{"abstract_id": "24279638", "label": "results", "text": "Six months after the intervention , statistically significant improvements in HRQoL were observed in physical functioning ( P = @ ) , pain ( P = @ ) and total FIQ score ( P = @ ) in the EG compared to the CG .", "sentence_id": 5}
+{"abstract_id": "24279638", "label": "results", "text": "The number of physical illnesses was identified as a predictor for improvement .", "sentence_id": 6}
+{"abstract_id": "24279638", "label": "conclusions", "text": "This interdisciplinary intervention has shown effectiveness in improving the HRQoL of this sample of patients with FM .", "sentence_id": 7}
+{"abstract_id": "24279638", "label": "conclusions", "text": "The number of physical illnesses was identified as a predictor of that improvement .", "sentence_id": 8}
+{"abstract_id": "24616448", "label": "objective", "text": "To determine the short-term efficacy of oral glucosamine supplementation by evaluating structural lesions in the knee joints , as assessed using @T magnetic resonance imaging ( MRI ) .", "sentence_id": 0}
+{"abstract_id": "24616448", "label": "methods", "text": "This study was designed as a randomized , double-blind , placebo-controlled trial .", "sentence_id": 1}
+{"abstract_id": "24616448", "label": "methods", "text": "Recruitment was performed via mass mailings and an arthritis registry in southwestern Pennsylvania .", "sentence_id": 2}
+{"abstract_id": "24616448", "label": "methods", "text": "In total , @ participants with mild-to-moderate pain in one or both knees , as defined by a Western Ontario and McMaster Universities Osteoarthritis Index ( WOMAC ) pain score @ and @ , were enrolled .", "sentence_id": 3}
+{"abstract_id": "24616448", "label": "methods", "text": "Of these subjects , @ % had a Kellgren/Lawrence grade @ in at least @ knee .", "sentence_id": 4}
+{"abstract_id": "24616448", "label": "methods", "text": "Participants received @ weeks of treatment with @,@ mg glucosamine hydrochloride in beverage form or a placebo beverage .", "sentence_id": 5}
+{"abstract_id": "24616448", "label": "methods", "text": "The primary outcome was decreased worsening of cartilage damage on @T MRI of both knees , assessed according to a validated scoring system , the Whole-Organ MRI Score ( WORMS ) .", "sentence_id": 6}
+{"abstract_id": "24616448", "label": "methods", "text": "Secondary outcomes included change in bone marrow lesion ( BML ) scores in all knees and change in excretion of urinary C-terminal crosslinking telopeptide of type II collagen ( CTX-II ) .", "sentence_id": 7}
+{"abstract_id": "24616448", "label": "results", "text": "The adjusted odds ratio ( OR ) for the likelihood of decreased cartilage damage over @ weeks in any WORMS-scored subregion of the knee in the glucosamine treatment group compared to the control group was @ ( @ % confidence interval -LSB- @ % CI -RSB- @ , @ ) .", "sentence_id": 8}
+{"abstract_id": "24616448", "label": "results", "text": "Compared to subjects treated with glucosamine , control subjects showed more improvement in BMLs ( adjusted OR @ , @ % CI @ , @ ) but no difference in worsening BMLs ( adjusted OR @ , @ % CI @ , @ ) over @ weeks .", "sentence_id": 9}
+{"abstract_id": "24616448", "label": "results", "text": "There was no indication that treatment with glucosamine decreased the excretion of urinary CTX-II ( = -@ , @ % CI -@ , @ ) .", "sentence_id": 10}
+{"abstract_id": "24616448", "label": "conclusions", "text": "The results of this short-term study provide no evidence of structural benefits ( i.e. , improvements in MRI morphologic features or urinary CTX-II excretion ) from glucosamine supplementation in individuals with chronic knee pain .", "sentence_id": 11}
+{"abstract_id": "24884501", "label": "background", "text": "Polymorphisms of genes encoding the Fcy receptors ( Fc fragment of IgG receptor @A ( FCGR@A ) and @A ( FCGR@A ) ) , which influence their affinity for the Fc fragment , have been linked to the pharmacodynamics of monoclonal antibodies .", "sentence_id": 0}
+{"abstract_id": "24884501", "label": "background", "text": "Most studies have been limited by small samples sizes and have reported inconsistent associations between the FCGR@A and the FCGR@A polymorphisms and clinical outcome in metastatic colorectal cancer ( mCRC ) patients treated with cetuximab .", "sentence_id": 1}
+{"abstract_id": "24884501", "label": "background", "text": "We investigated the association of these polymorphisms and clinical outcome in a large cohort of mCRC patients treated with first-line @-fluorouracil/folinic acid and oxaliplatin ( Nordic FLOX ) + / - cetuximab in the NORDIC-VII study ( NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "24884501", "label": "methods", "text": "@ and @ mCRC patients were evaluable for the FCGR@A and FCGR@A genotyping , respectively .", "sentence_id": 3}
+{"abstract_id": "24884501", "label": "methods", "text": "Genotyping was performed on TaqMan ABI HT @ ( Applied Biosystems , Foster City , CA , USA ) with pre-designed SNP genotyping assays for FCGR@A ( rs@ ) and FCGR@A ( rs@ ) .", "sentence_id": 4}
+{"abstract_id": "24884501", "label": "results", "text": "The response rate for patients with the FCGR@A R/R genotype was significantly increased when cetuximab was added to Nordic FLOX ( @ % versus @ % , interaction P = @ ) , but was not significantly different compared to the response rate of patients with the FCGR@A H/H or H/R genotypes given the same treatment .", "sentence_id": 5}
+{"abstract_id": "24884501", "label": "results", "text": "A larger increase in response rate with the addition of cetuximab to Nordic FLOX in patients with KRAS mutated tumors and the FCGR@A R/R genotype was observed ( @ % versus @ % , interaction P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24884501", "label": "results", "text": "None of the FCGR@A polymorphisms were associated with altered response when cetuximab was added to Nordic FLOX ( interaction P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24884501", "label": "results", "text": "Neither of the FCGR polymorphisms showed any significant associations with progression-free survival or overall survival .", "sentence_id": 8}
+{"abstract_id": "24884501", "label": "conclusions", "text": "Patients with KRAS mutated tumors and the FCGR@A R/R polymorphism responded poorly when treated with chemotherapy only , and experienced the most benefit of the addition of cetuximab in terms of response rate .", "sentence_id": 9}
+{"abstract_id": "25112521", "label": "background", "text": "There is a large body of evidence for the involvement of the parietal cortex in orientation and navigation in space .", "sentence_id": 0}
+{"abstract_id": "25112521", "label": "background", "text": "This has been supplemented by investigation of the contribution of a number of subregions using transcranial magnetic stimulation .", "sentence_id": 1}
+{"abstract_id": "25112521", "label": "objective", "text": "The role of the precuneus area , located in the medial plane of posterior parietal cortex ( PPC ) , in visuospatial functions is not well understood .", "sentence_id": 2}
+{"abstract_id": "25112521", "label": "objective", "text": "We investigated the contribution of this area using the landmark task .", "sentence_id": 3}
+{"abstract_id": "25112521", "label": "methods", "text": "Participants were asked to make forced-choice judgments of which side of prebisected line was longer for near and far viewing conditions ( @ and @cm , respectively ) .", "sentence_id": 4}
+{"abstract_id": "25112521", "label": "methods", "text": "Online @Hz , repetitive transcranial magnetic stimulation ( rTMS ) was delivered for @ms over the right precuneus , rPPC and vertex ( control ) , in separate blocks of trials .", "sentence_id": 5}
+{"abstract_id": "25112521", "label": "methods", "text": "The rPPC stimulation was used as a positive control , having previously resulted in `` neglect like '' spatial bias effects in a number of studies .", "sentence_id": 6}
+{"abstract_id": "25112521", "label": "results", "text": "A no-TMS condition showed a leftward spatial bias ( pseudoneglect ) for near space judgments but not for far space and was used as the baseline .", "sentence_id": 7}
+{"abstract_id": "25112521", "label": "results", "text": "Precuneus stimulation resulted in rightward spatial bias from the midpoint in near space similar to the rPPC neglect-like effect .", "sentence_id": 8}
+{"abstract_id": "25112521", "label": "results", "text": "No significant effects were seen with vertex stimulation .", "sentence_id": 9}
+{"abstract_id": "25112521", "label": "conclusions", "text": "This study shows that precuneus , like other parietal areas , is involved in visuospatial functions .", "sentence_id": 10}
+{"abstract_id": "25112521", "label": "conclusions", "text": "Further work is required to clarify how the contribution of this area differs from other parietal regions .", "sentence_id": 11}
+{"abstract_id": "26126565", "label": "objective", "text": "To determine whether Care Navigation ( CN ) , a nurse-led hospital-based coordinated care intervention , reduced the use of hospital services and improved quality of life for patients with chronic illness .", "sentence_id": 0}
+{"abstract_id": "26126565", "label": "methods", "text": "Randomised controlled trial ; participants were allocated to CN or standard care .", "sentence_id": 1}
+{"abstract_id": "26126565", "label": "methods", "text": "Patients with chronic illness presenting to the emergency department of Nepean Hospital , Sydney , New South Wales .", "sentence_id": 2}
+{"abstract_id": "26126565", "label": "methods", "text": "High-risk status for an unplanned admission was defined as i ) three or more unplanned hospital admissions in @ months for patients aged @ or at least one admission for cardiac or respiratory disease in patients aged @-@ years ; or ii ) judged by a CN nurse to be high risk and likely to benefit .", "sentence_id": 3}
+{"abstract_id": "26126565", "label": "methods", "text": "Numbers of re-presentations or readmissions , quality of life , time to re-presentation , readmission or death , length of stay , and access to hospital and community health services .", "sentence_id": 4}
+{"abstract_id": "26126565", "label": "results", "text": "@ participants were randomised between May @ and February @ ; @ by previous unplanned admission and @ by clinical impression .", "sentence_id": 5}
+{"abstract_id": "26126565", "label": "results", "text": "The CN group received more community health services ( rate ratio , @ ; @ % CI , @-@ @ ; P < @ ) than participants receiving standard care ; however , this did not result in statistically significant differences in number of re-presentations ( rate ratio , @ ; @ % CI , @-@ @ ; P = @ ) , number of readmissions ( rate ratio , @ ; @ % CI , @-@ @ ; P = @ ) , quality of life at @ months ( mean difference , @ ; @ % CI , -@ to @ , P = @ ) , or other measures .", "sentence_id": 6}
+{"abstract_id": "26126565", "label": "conclusions", "text": "CN did not improve quality of life or reduce unplanned hospital presentations or admissions despite community health services almost doubling .", "sentence_id": 7}
+{"abstract_id": "26126565", "label": "conclusions", "text": "Future service development should explore potential benefits of linking navigated intrahospital care to ongoing , proactive care planning and delivery in the community .", "sentence_id": 8}
+{"abstract_id": "24952836", "label": "objective", "text": "For people with chronic low back pain , does Kinesio Taping , applied according to the treatment manual to create skin convolutions , reduce pain and disability more than a simple application without convolutions ?", "sentence_id": 0}
+{"abstract_id": "24952836", "label": "methods", "text": "Randomised trial with concealed allocation , intention-to-treat analysis and blinded assessment of some outcomes .", "sentence_id": 1}
+{"abstract_id": "24952836", "label": "methods", "text": "@ participants with chronic non-specific low back pain .", "sentence_id": 2}
+{"abstract_id": "24952836", "label": "methods", "text": "Experimental group participants received eight sessions ( over four weeks ) of Kinesio Taping applied according to the Kinesio Taping Method treatment manual ( ie , @ to @ % tension applied in flexion to create skin convolutions in neutral ) .", "sentence_id": 3}
+{"abstract_id": "24952836", "label": "methods", "text": "Control group participants received eight sessions ( over four weeks ) of Kinesio Taping with no tension , creating no convolutions .", "sentence_id": 4}
+{"abstract_id": "24952836", "label": "methods", "text": "The primary outcome measures were pain intensity and disability after the four-week intervention .", "sentence_id": 5}
+{"abstract_id": "24952836", "label": "methods", "text": "Secondary outcomes were pain intensity and disability @ weeks after randomisation , and global perceived effect at both four and @ weeks after randomisation .", "sentence_id": 6}
+{"abstract_id": "24952836", "label": "results", "text": "Applying Kinesio Tape to create convolutions in the skin did not significantly change its effect on pain ( MD-@ @ points , @ % CI-@ @ to @ ) or disability ( MD-@ @ points , @ % CI-@ @ to @ ) at four weeks .", "sentence_id": 7}
+{"abstract_id": "24952836", "label": "results", "text": "There was a small difference in favour of the experimental group for the secondary outcome of global perceived effect ( MD @ points , @ % CI @ to @ ) at four weeks .", "sentence_id": 8}
+{"abstract_id": "24952836", "label": "results", "text": "No significant between-group differences were observed for the other secondary outcomes .", "sentence_id": 9}
+{"abstract_id": "24952836", "label": "conclusions", "text": "Kinesio Taping applied with stretch to generate convolutions in the skin was no more effective than simple application of the tape without tension for the outcomes measured .", "sentence_id": 10}
+{"abstract_id": "24952836", "label": "conclusions", "text": "These results challenge the proposed mechanism of action of this therapy .", "sentence_id": 11}
+{"abstract_id": "24599111", "label": "objective", "text": "The estimation of effect size in clinical trials commonly disregards recurrent outcomes .", "sentence_id": 0}
+{"abstract_id": "24599111", "label": "objective", "text": "We investigated the effectiveness of a complex intervention on recurrent outcomes in patients with type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "24599111", "label": "methods", "text": "In the Diabetes Care in General Practice ( DCGP ) randomised controlled trial , @,@ patients newly diagnosed with type @ diabetes were randomised to @ years of structured personal care or routine care ( ClinicalTrials.gov NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "24599111", "label": "methods", "text": "The trial had @ years of registry-based follow-up and was analysed with Cox regression models .", "sentence_id": 3}
+{"abstract_id": "24599111", "label": "methods", "text": "Repeated occurrences in the same patient of outcomes ( any diabetes-related endpoint , myocardial infarction -LSB- MI -RSB- , stroke , peripheral vascular disease and microvascular disease ) were accounted for with the Wei , Lin and Weissfeld method .", "sentence_id": 4}
+{"abstract_id": "24599111", "label": "results", "text": "As previously shown , the intervention reduced the rates of first occurrence of both MI and any diabetes-related endpoint .", "sentence_id": 5}
+{"abstract_id": "24599111", "label": "results", "text": "However , for all outcomes , the HR for a second event showed a statistically non-significant tendency to be increased .", "sentence_id": 6}
+{"abstract_id": "24599111", "label": "results", "text": "We estimated a combined HR for all marginal failure times , regardless of whether they were first , second or later events .", "sentence_id": 7}
+{"abstract_id": "24599111", "label": "results", "text": "This showed that the intervention had no effect on the rate of any of the outcomes , including MI ( HR @ , @ % CI @ , @ ) and any diabetes-related endpoint ( HR @ , @ % CI @ , @ ) .", "sentence_id": 8}
+{"abstract_id": "24599111", "label": "conclusions", "text": "In the DCGP study , a smaller proportion of patients who received structured care experienced a first occurrence of MI or any diabetes-related endpoint compared with patients who received routine care .", "sentence_id": 9}
+{"abstract_id": "24599111", "label": "conclusions", "text": "However , the patients who received structured care tended to experience more recurrent outcomes , so the total outcome rate was not affected by the intervention .", "sentence_id": 10}
+{"abstract_id": "24315894", "label": "objective", "text": "This study sought to report additional safety results from the ROCKET AF ( Rivaroxaban Once-daily oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation ) .", "sentence_id": 0}
+{"abstract_id": "24315894", "label": "background", "text": "The ROCKET AF trial demonstrated similar risks of stroke/systemic embolism and major/nonmajor clinically relevant bleeding ( principal safety endpoint ) with rivaroxaban and warfarin .", "sentence_id": 1}
+{"abstract_id": "24315894", "label": "methods", "text": "The risk of the principal safety and component bleeding endpoints with rivaroxaban versus warfarin were compared , and factors associated with major bleeding were examined in a multivariable model .", "sentence_id": 2}
+{"abstract_id": "24315894", "label": "results", "text": "The principal safety endpoint was similar in the rivaroxaban and warfarin groups ( @ vs. @ events/@ patient-years ; hazard ratio : @ ; @ % confidence interval : @ to @ ) .", "sentence_id": 3}
+{"abstract_id": "24315894", "label": "results", "text": "Major bleeding risk increased with age , but there were no differences between treatments in each age category ( < @ , @ to @,@ years ; pinteraction = @ ) .", "sentence_id": 4}
+{"abstract_id": "24315894", "label": "results", "text": "Compared with those without ( n = @,@ ) , patients with a major bleed ( n = @ ) were more likely to be older , current/prior smokers , have prior gastrointestinal ( GI ) bleeding , mild anemia , and a lower calculated creatinine clearance and less likely to be female or have a prior stroke/transient ischemic attack .", "sentence_id": 5}
+{"abstract_id": "24315894", "label": "results", "text": "Increasing age , baseline diastolic blood pressure ( DBP ) @ mm Hg , history of chronic obstructive pulmonary disease or GI bleeding , prior acetylsalicylic acid use , and anemia were independently associated with major bleeding risk ; female sex and DBP < @ mm Hg were associated with a decreased risk .", "sentence_id": 6}
+{"abstract_id": "24315894", "label": "conclusions", "text": "Rivaroxaban and warfarin had similar risk for major/nonmajor clinically relevant bleeding .", "sentence_id": 7}
+{"abstract_id": "24315894", "label": "conclusions", "text": "Age , sex , DBP , prior GI bleeding , prior acetylsalicylic acid use , and anemia were associated with the risk of major bleeding .", "sentence_id": 8}
+{"abstract_id": "24315894", "label": "conclusions", "text": "( An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation : NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "24423913", "label": "objective", "text": "To compare the efficacy of laryngeal mask airway-Supreme ( TM ) versus common laryngeal mask airway in children with general anesthesia .", "sentence_id": 0}
+{"abstract_id": "24423913", "label": "methods", "text": "With local research ethics committee 's approval and written informed parental consent , @ children were randomly divided into groups L ( size @ common laryngeal mask airway ) and S ( size @ laryngeal mask airway-Supreme ( TM ) ) according to random number ( n = @ each ) .", "sentence_id": 1}
+{"abstract_id": "24423913", "label": "methods", "text": "After anesthesia induction , a common laryngeal mask airway or laryngeal mask airway-Supreme ( TM ) was inserted and mechanically ventilated .", "sentence_id": 2}
+{"abstract_id": "24423913", "label": "methods", "text": "Time and ease for insertion , insertion success rate , airway leak pressure , success rate and ease of disposal sputum collecting tube insertion in group S , quality of airway during anesthetic maintenance , abdominal circumference changes and complications within @ h post-operation were measured .", "sentence_id": 3}
+{"abstract_id": "24423913", "label": "results", "text": "Compared with group L , abdominal circumference increased less in group S ( @ @ vs @ @ cm , n = @ , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24423913", "label": "results", "text": "No significant inter-group differences existed for other measurements .", "sentence_id": 5}
+{"abstract_id": "24423913", "label": "results", "text": "Disposal sputum collecting tube was successfully placed in group S ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "24423913", "label": "conclusions", "text": "In children with mechanical ventilation , laryngeal mask airway-Supreme ( TM ) can be effectively applied to maintain a good airway .", "sentence_id": 7}
+{"abstract_id": "24423913", "label": "conclusions", "text": "And the incidence of gastric insufflation is lower .", "sentence_id": 8}
+{"abstract_id": "24423913", "label": "conclusions", "text": "It is particularly useful for those requiring evacuation of gastric contents during general anesthesia .", "sentence_id": 9}
+{"abstract_id": "25397800", "label": "objective", "text": "The purpose of this trial was to evaluate crestal bone level changes radiographically in a standardized fashion over a period of @ months in humans for implants with a @-mm machined collar ( implant type A ) versus type B implants with a @-mm machined collar .", "sentence_id": 0}
+{"abstract_id": "25397800", "label": "methods", "text": "Twenty-five patients with multiple missing teeth in posterior sectors were randomly assigned to one of the two groups : A ( @-mm machined-collar implants ) or B ( @-mm machined-collar implants ) .", "sentence_id": 1}
+{"abstract_id": "25397800", "label": "methods", "text": "Changes at crestal bone level were assessed by measuring the shoulder-crest distance ( SCD ) on the mesial and distal aspects of each implant on customized periapical radiographs , which were taken on the day of surgery and @ , @ , and @ months after surgery .", "sentence_id": 2}
+{"abstract_id": "25397800", "label": "results", "text": "Eighty-one implants were included in the study .", "sentence_id": 3}
+{"abstract_id": "25397800", "label": "results", "text": "Mean SCD was @ @ mm at baseline and @ @ mm after @ months .", "sentence_id": 4}
+{"abstract_id": "25397800", "label": "results", "text": "For @-mm-collar implants , mean SCD was @ @ mm , while it was @ @ mm for @-mm-collar implants .", "sentence_id": 5}
+{"abstract_id": "25397800", "label": "results", "text": "Statistically significant differences were found only between the two types of implants for distal measurements at @ and @ months after placement .", "sentence_id": 6}
+{"abstract_id": "25397800", "label": "conclusions", "text": "Both @ - and @-mm machined-collar implants can be used with predictable results , as changes in peri-implant crestal bone levels are similar for both implant types and do not seem to be significant from a clinical point of view .", "sentence_id": 7}
+{"abstract_id": "25397800", "label": "conclusions", "text": "The SCD may well depend more on the location of the abutment-implant interface than on machined-collar height .", "sentence_id": 8}
+{"abstract_id": "24725582", "label": "objective", "text": "To explore the early childhood pulmonary outcomes of infants who participated in the National Institute of Child Health and Human Development 's Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial ( SUPPORT ) , using a factorial design that randomized extremely preterm infants to lower vs higher oxygen saturation targets and delivery room continuous positive airway pressure ( CPAP ) vs intubation/surfactant .", "sentence_id": 0}
+{"abstract_id": "24725582", "label": "methods", "text": "The Breathing Outcomes Study , a prospective secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial , assessed respiratory morbidity at @-month intervals from hospital discharge to @-@ months corrected age ( CA ) .", "sentence_id": 1}
+{"abstract_id": "24725582", "label": "methods", "text": "Two prespecified primary outcomes-wheezing more than twice per week during the worst @-week period and cough longer than @ days without a cold-were compared for each randomized intervention .", "sentence_id": 2}
+{"abstract_id": "24725582", "label": "results", "text": "One or more interviews were completed for @ of the @ eligible infants .", "sentence_id": 3}
+{"abstract_id": "24725582", "label": "results", "text": "The incidences of wheezing and cough were @ % and @ % , respectively , and did not differ between the study arms of either randomized intervention .", "sentence_id": 4}
+{"abstract_id": "24725582", "label": "results", "text": "Infants randomized to lower vs higher oxygen saturation targets had a similar risk of death or respiratory morbidity ( except for croup and treatment with oxygen or diuretics at home ) .", "sentence_id": 5}
+{"abstract_id": "24725582", "label": "results", "text": "Infants randomized to CPAP vs intubation/surfactant had fewer episodes of wheezing without a cold ( @ % vs @ % ; P < @ ) , respiratory illnesses diagnosed by a doctor ( @ % vs @ % ; P < @ ) , and physician or emergency room visits for breathing problems ( @ % vs @ % ; P < @ ) by @-@ months CA .", "sentence_id": 6}
+{"abstract_id": "24725582", "label": "conclusions", "text": "Treatment with early CPAP rather than intubation/surfactant is associated with less respiratory morbidity by @-@ months CA .", "sentence_id": 7}
+{"abstract_id": "24725582", "label": "conclusions", "text": "Longitudinal assessment of pulmonary morbidity is necessary to fully evaluate the potential benefits of respiratory interventions for neonates .", "sentence_id": 8}
+{"abstract_id": "24837862", "label": "objective", "text": "To evaluate whether a polyethylene total body wrapping ( covering both the body and head ) is more effective than conventional treatment ( covering up to the shoulders ) in reducing perinatal thermal losses in very preterm infants .", "sentence_id": 0}
+{"abstract_id": "24837862", "label": "methods", "text": "This was a multicenter , prospective , randomized , parallel @:@ , unblinded , controlled trial of infants < @ weeks ' gestation age , comprising two study groups : experimental group ( total body group ; both the body and head covered with a polyethylene occlusive bag , with the face uncovered ) and control group ( only the body , up to the shoulders , covered with a polyethylene occlusive bag ) .", "sentence_id": 1}
+{"abstract_id": "24837862", "label": "methods", "text": "The primary outcome was axillary temperature on neonatal intensive care unit admission immediately after wrap removal .", "sentence_id": 2}
+{"abstract_id": "24837862", "label": "results", "text": "One hundred randomly allocated infants ( @ in the total body group and @ controls ) completed the study .", "sentence_id": 3}
+{"abstract_id": "24837862", "label": "results", "text": "Mean axillary temperature on neonatal intensive care unit admission was similar in the two groups ( @ C total body vs @ C controls ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24837862", "label": "results", "text": "The rate of moderate hypothermia ( temperature < @C ) was @ % in the total body group and @ % in the control group ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24837862", "label": "results", "text": "Three subjects in each group ( @ % ) had an axillary temperature > @ C on admission , and one subject in control group had an axillary temperature > @C .", "sentence_id": 6}
+{"abstract_id": "24837862", "label": "conclusions", "text": "Total body wrapping is comparable with covering the body up to the shoulders in preventing postnatal thermal losses in very preterm infants .", "sentence_id": 7}
+{"abstract_id": "24231627", "label": "background", "text": "Available preclinical and phase @ clinical data suggest that the addition of cetuximab , a monoclonal antibody directed against the epidermal growth factor receptor ( EGFR ) , to chemotherapy might improve outcome in patients with advanced non-small-cell lung cancer ( NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "24231627", "label": "background", "text": "We aimed to assess whether the addition of cetuximab to chemotherapy improved progression-free survival in patients with recurrent or progressive NSCLC after platinum-based therapy .", "sentence_id": 1}
+{"abstract_id": "24231627", "label": "methods", "text": "In this unmasked , open-label randomised phase @ trial we enrolled patients with metastatic , unresectable , or locally advanced NSCLC from @ sites in Canada and the USA .", "sentence_id": 2}
+{"abstract_id": "24231627", "label": "methods", "text": "Eligible patients were those aged @ years or older who had experienced progressive disease during or after one previous platinum-based regimen .", "sentence_id": 3}
+{"abstract_id": "24231627", "label": "methods", "text": "Initially , patients were randomly assigned to receive either pemetrexed ( @ mg/m ( @ ) ) or docetaxel ( @ mg/m ( @ ) ) and then randomly assigned within each group to receive their chemotherapy with or without cetuximab ( @ mg/m ( @ ) at first dose and @ mg/m ( @ ) weekly thereafter ) until disease progression or unacceptable toxicity .", "sentence_id": 4}
+{"abstract_id": "24231627", "label": "methods", "text": "However , after a change in the standard of care , investigators chose whether to treat with pemetrexed or docetaxel on a patient-by-patient basis .", "sentence_id": 5}
+{"abstract_id": "24231627", "label": "methods", "text": "The primary analysis was changed to compare progression-free survival with cetuximab plus pemetrexed versus pemetrexed , on an intention-to-treat basis .", "sentence_id": 6}
+{"abstract_id": "24231627", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "24231627", "label": "results", "text": "Between Jan @ , @ , and Feb @ , @ , we enrolled @ patients ; data for one patient was accidentally discarded .", "sentence_id": 8}
+{"abstract_id": "24231627", "label": "results", "text": "Of the remaining @ patients , @ received pemetrexed ( @ patients with cetuximab and @ alone ) and @ received docetaxel ( @ in combination with cetuximab and @ alone ) .", "sentence_id": 9}
+{"abstract_id": "24231627", "label": "results", "text": "Median progression-free survival with cetuximab plus pemetrexed was @ months ( @ % CI @-@ ) versus @ months ( @-@ ) with pemetrexed ( HR @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24231627", "label": "results", "text": "The most common grade @-@ adverse events with cetuximab plus pemetrexed were fatigue ( @ -LSB- @ % -RSB- of @ patients ) , acneiform rash ( @ -LSB- @ % -RSB- ) , dyspnoea ( @ -LSB- @ % -RSB- ) , and decreased neutrophil count ( @ -LSB- @ % -RSB- ) , and with pemetrexed alone were dyspnoea ( @ -LSB- @ % -RSB- of @ patients ) , decreased neutrophil count ( @ -LSB- @ % -RSB- ) , and fatigue ( @ -LSB- @ % -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "24231627", "label": "results", "text": "A significantly higher proportion of patients in the cetuximab plus pemetrexed group ( @ -LSB- @ % -RSB- of @ patients ) experienced at least one serious adverse event than those patients in the pemetrexed group ( @ -LSB- @ % -RSB- of @ patients ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24231627", "label": "results", "text": "Nine ( @ % ) of @ treated patients in the cetuximab and pemetrexed group died of adverse events compared with five ( @ % ) of @ treated patients in the pemetrexed alone group .", "sentence_id": 13}
+{"abstract_id": "24231627", "label": "conclusions", "text": "The use of cetuximab is not recommended in combination with chemotherapy in patients previously treated with platinum-based therapy .", "sentence_id": 14}
+{"abstract_id": "25522389", "label": "background", "text": "Some studies suggest better overall outcomes when right unilateral electroconvulsive therapy ( RUL ECT ) is given with an ultrabrief , rather than brief , pulse width .", "sentence_id": 0}
+{"abstract_id": "25522389", "label": "methods", "text": "The aim of the study was to test if ultrabrief-pulse RUL ECT results in less cognitive side effects than brief - pulse RUL ECT , when given at doses which achieve comparable efficacy .", "sentence_id": 1}
+{"abstract_id": "25522389", "label": "methods", "text": "One hundred and two participants were assigned to receive ultrabrief ( at @ times seizure threshold ) or brief ( at @ times seizure threshold ) pulse RUL ECT in a double-blind , randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "25522389", "label": "methods", "text": "Blinded raters assessed mood and cognitive functioning over the ECT course .", "sentence_id": 3}
+{"abstract_id": "25522389", "label": "results", "text": "Efficacy outcomes were not found to be significantly different .", "sentence_id": 4}
+{"abstract_id": "25522389", "label": "results", "text": "The ultrabrief group showed less cognitive impairment immediately after a single session of ECT , and over the treatment course ( autobiographical memory , orientation ) .", "sentence_id": 5}
+{"abstract_id": "25522389", "label": "conclusions", "text": "In summary , when ultrabrief RUL ECT was given at a higher dosage than brief RUL ECT ( @ versus @ times seizure threshold ) , efficacy was comparable while cognitive impairment was less .", "sentence_id": 6}
+{"abstract_id": "25245767", "label": "background", "text": "We compared the effects of intravenous lidocaine ( IVL ) with lumbar epidural lidocaine analgesia ( LEA ) on pain and ileus after open colonic surgery .", "sentence_id": 0}
+{"abstract_id": "25245767", "label": "methods", "text": "Between December @ and February @ , @ patients were randomly allocated to IVL , LEA , or control group .", "sentence_id": 1}
+{"abstract_id": "25245767", "label": "methods", "text": "The IVL group received intraoperatively lidocaine @ % intravenously ( @ mg/kg bolus , @ mg/kg/h infusion ) and normal saline ( NS ) epidurally .", "sentence_id": 2}
+{"abstract_id": "25245767", "label": "methods", "text": "The LEA group received lidocaine epidurally ( @ mg/kg bolus , @ mg/kg/h infusion ) and NS intravenously .", "sentence_id": 3}
+{"abstract_id": "25245767", "label": "methods", "text": "The control group received NS both intravenously and epidurally , as bolus and infusion .", "sentence_id": 4}
+{"abstract_id": "25245767", "label": "methods", "text": "All NS volumes were calculated as if containing lidocaine @ % at the aforementioned doses .", "sentence_id": 5}
+{"abstract_id": "25245767", "label": "methods", "text": "We assessed pain intensity at rest/cough at @ , @ , @ , @ , @ , and @ h postoperatively ( numerical rating scale @-@ ) , @-h analgesic consumption , and time to first flatus passage .", "sentence_id": 6}
+{"abstract_id": "25245767", "label": "results", "text": "Data from @ patients ( @ per group ) were analyzed .", "sentence_id": 7}
+{"abstract_id": "25245767", "label": "results", "text": "The IVL group had significantly lower pain scores at rest and cough compared to LEA or control group only at @ , @ , and @ h postoperatively ( P < @ for all comparisons ) .", "sentence_id": 8}
+{"abstract_id": "25245767", "label": "results", "text": "The @-h analgesic requirements and time to first flatus passage did not differ significantly between IVL group and LEA or control group ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25245767", "label": "conclusions", "text": "Compared with LEA-lidocaine or placebo , intravenous lidocaine offered no clinically significant benefit in terms of analgesia and bowel function .", "sentence_id": 10}
+{"abstract_id": "24983434", "label": "objective", "text": "To compare patient satisfaction between telemedicine and in-person follow-up appointments for orthopedic trauma .", "sentence_id": 0}
+{"abstract_id": "24983434", "label": "methods", "text": "Prospective randomized controlled trial ( pilot study ) .", "sentence_id": 1}
+{"abstract_id": "24983434", "label": "methods", "text": "Level I trauma center .", "sentence_id": 2}
+{"abstract_id": "24983434", "label": "methods", "text": "Twenty-four patients were enrolled and randomized into @ groups .", "sentence_id": 3}
+{"abstract_id": "24983434", "label": "methods", "text": "Eight patients who had telemedicine follow-up appointments and @ who had in-person follow-up visits were included in a per-protocol analysis .", "sentence_id": 4}
+{"abstract_id": "24983434", "label": "methods", "text": "In the telemedicine group , @ patients left the study because of nonadherence , @ patient withdrew because of a weak Internet connection , and @ patient sustained an open fracture .", "sentence_id": 5}
+{"abstract_id": "24983434", "label": "methods", "text": "Three control patients left the study because of nonadherence .", "sentence_id": 6}
+{"abstract_id": "24983434", "label": "methods", "text": "The patients had @ follow-up appointments during a @-month period .", "sentence_id": 7}
+{"abstract_id": "24983434", "label": "methods", "text": "Patients either had their @-week and @-month follow-ups through video calls or in the clinic .", "sentence_id": 8}
+{"abstract_id": "24983434", "label": "methods", "text": "After @-week and @-month follow-up appointments , the patients were given survey questions that were developed using literature-supported methods to compare follow-up experiences .", "sentence_id": 9}
+{"abstract_id": "24983434", "label": "methods", "text": "The patients were monitored for complications .", "sentence_id": 10}
+{"abstract_id": "24983434", "label": "results", "text": "There was no significant difference in patient satisfaction between telemedicine and in-person clinic visits ( telemedicine : @ % satisfied ; control : @ % satisfied ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24983434", "label": "results", "text": "Zero percent of patients in the telemedicine group took time off their work for their appointment compared with @ % in the control ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24983434", "label": "results", "text": "Telemedicine patients spent significantly less time on their visits ( P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24983434", "label": "results", "text": "The majority of the patients in the telemedicine group reported clear visual ( @ % ) and sound quality ( @ % ) through and agreed to future follow-up visits through telemedicine ( @ % ) .", "sentence_id": 14}
+{"abstract_id": "24983434", "label": "results", "text": "One patient in each group developed complications .", "sentence_id": 15}
+{"abstract_id": "24983434", "label": "conclusions", "text": "Telemedicine may be a viable alternative to some in-person clinic visits because of similar measures of patient satisfaction but with significantly less time and distance traveled .", "sentence_id": 16}
+{"abstract_id": "24983434", "label": "methods", "text": "Therapeutic level II .", "sentence_id": 17}
+{"abstract_id": "24983434", "label": "methods", "text": "See Instructions for authors for a complete description of levels of evidence .", "sentence_id": 18}
+{"abstract_id": "25179493", "label": "background", "text": "Chronic hepatitis B ( CHB ) is a major public health concern , particularly in endemic areas like Asia-Pacific .", "sentence_id": 0}
+{"abstract_id": "25179493", "label": "background", "text": "Sustained virologic suppression correlates with regression of histologic fibrosis and cirrhosis .", "sentence_id": 1}
+{"abstract_id": "25179493", "label": "objective", "text": "This study evaluated efficacy and safety of tenofovir disoproxil fumarate ( TDF ) in Asian patients through @ weeks of treatment .", "sentence_id": 2}
+{"abstract_id": "25179493", "label": "methods", "text": "Post hoc analysis of the Asian subpopulation from two phase @ clinical studies was performed .", "sentence_id": 3}
+{"abstract_id": "25179493", "label": "methods", "text": "Following a @-week randomized , double-blind evaluation of once-daily TDF versus once-daily adefovir dipivoxil , open-label TDF for up to @ weeks was evaluated .", "sentence_id": 4}
+{"abstract_id": "25179493", "label": "methods", "text": "Patients with both baseline and week @ liver biopsies were evaluated for histologic changes .", "sentence_id": 5}
+{"abstract_id": "25179493", "label": "results", "text": "At baseline , @/@ ( @ % ) patients randomized were Asian .", "sentence_id": 6}
+{"abstract_id": "25179493", "label": "results", "text": "Sixty-eight percent of Asian patients were male ; @ % were hepatitis B e antigen ( HBeAg ) - positive .", "sentence_id": 7}
+{"abstract_id": "25179493", "label": "results", "text": "At week @ , similar proportions of Asian ( @ % ) and non-Asian ( @ % ) patients demonstrated improvement in liver histology , and @/@ ( @ % ) Asian patients with baseline cirrhosis were no longer cirrhotic .", "sentence_id": 8}
+{"abstract_id": "25179493", "label": "results", "text": "By modified intent-to-treat analysis , @ % of Asian patients and @ % of non-Asian patients had HBV DNA < @ copies/mL at the end of week @ ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25179493", "label": "results", "text": "No differences were seen in HBeAg loss or seroconversion in Asian versus non-Asian patients .", "sentence_id": 10}
+{"abstract_id": "25179493", "label": "results", "text": "No Asian patient experienced hepatitis B surface antigen loss .", "sentence_id": 11}
+{"abstract_id": "25179493", "label": "results", "text": "Safety and tolerability of TDF through week @ , including changes in renal function and in hip/spine bone mineral density ( from weeks @ to @ ) , were comparable between Asian and non-Asian patients .", "sentence_id": 12}
+{"abstract_id": "25179493", "label": "conclusions", "text": "Long-term virologic and histologic efficacy and safety of TDF are comparable in Asian and non-Asian CHB patients .", "sentence_id": 13}
+{"abstract_id": "24909093", "label": "objective", "text": "To study the effect of exogenous i.m. glucagon on recovery from controlled insulin-induced hypoglycaemia in patients with type @ diabetes treated with the novel glucokinase activator AZD@ , in combination with metformin .", "sentence_id": 0}
+{"abstract_id": "24909093", "label": "methods", "text": "This was a single-centre randomized , open , two-way crossover phase I , automated glucose clamp ( Biostator ( ) ; Life Science Instruments , Elkhart , MD , USA ) study ( NCT@ ) in eight patients ( seven men and one woman , mean age @ years , body mass index @ kg/m ( @ ) ) .", "sentence_id": 1}
+{"abstract_id": "24909093", "label": "methods", "text": "All patients received a stable dose of metformin twice daily , ranging from @ to @ mg .", "sentence_id": 2}
+{"abstract_id": "24909093", "label": "methods", "text": "A @-day titration phase commenced with @ mg AZD@ twice daily , escalating to @ mg twice daily if tolerated .", "sentence_id": 3}
+{"abstract_id": "24909093", "label": "methods", "text": "This was followed by a single dose of @ or @ mg AZD@ , administered on days @ and @ when metabolic studies were performed .", "sentence_id": 4}
+{"abstract_id": "24909093", "label": "methods", "text": "After an overnight fast on days @ and @ , controlled hypoglycaemia was induced using an exogenous i.v. infusion of insulin .", "sentence_id": 5}
+{"abstract_id": "24909093", "label": "methods", "text": "Plasma glucose was lowered in a stepwise fashion over @ h to attain a target nadir of @ mmol/l .", "sentence_id": 6}
+{"abstract_id": "24909093", "label": "methods", "text": "This was sustained for @ min , at the end of which the hypoglycaemic clamp was released .", "sentence_id": 7}
+{"abstract_id": "24909093", "label": "methods", "text": "In random sequence , patients either received an i.m. injection of @ mg glucagon or were allowed to recover from hypoglycaemia by endogenous counter-regulation .", "sentence_id": 8}
+{"abstract_id": "24909093", "label": "methods", "text": "To avoid prolonged hypoglycaemia , a reverse glucose clamp was applied from @ to @ h post-dose .", "sentence_id": 9}
+{"abstract_id": "24909093", "label": "results", "text": "Three patients received @ mg AZD@ twice daily and five patients @ mg twice daily .", "sentence_id": 10}
+{"abstract_id": "24909093", "label": "results", "text": "Mean plasma glucose at @ min after release of the hypoglycaemic clamp was significantly lower ( @ @ mmol/l ) for AZD@ alone than for AZD@ + glucagon ( @ @ mmol/l ; p < @ between the groups ) .", "sentence_id": 11}
+{"abstract_id": "24909093", "label": "results", "text": "Catecholamine and cortisol responses were similar on the AZD@ + glucagon and AZD alone study days .", "sentence_id": 12}
+{"abstract_id": "24909093", "label": "results", "text": "Growth hormone response was @ % lower for AZD@ alone ( p = @ ) , consistent with the effect of a pharmacological dose of glucagon on growth hormone secretion .", "sentence_id": 13}
+{"abstract_id": "24909093", "label": "results", "text": "No safety or tolerability concerns were observed during treatment with AZ@ .", "sentence_id": 14}
+{"abstract_id": "24909093", "label": "conclusions", "text": "Exogenous glucagon was effective as a rescue treatment for hypoglycaemia induced during treatment with AZD@ , given in combination with metformin in patients with type @ diabetes .", "sentence_id": 15}
+{"abstract_id": "25358059", "label": "objective", "text": "Retrograde intrarenal surgery ( RIRS ) involves a minimally invasive stone surgery , lending itself potential to combined spinal-epidural anesthesia ( CSEA ) , although it is performed preferably under general anesthesia ( GA ) .", "sentence_id": 0}
+{"abstract_id": "25358059", "label": "objective", "text": "This prospective randomized study was undertaken to evaluate the feasibility and efficacy of CSEA for patients undergoing RIRS .", "sentence_id": 1}
+{"abstract_id": "25358059", "label": "methods", "text": "Seventy consecutive patients who were scheduled for RIRS were randomized to receive CSEA ( n = @ ) or GA ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25358059", "label": "methods", "text": "Operative time , stone clearance rate , visual analog scale ( VAS ) of pain , complication rate , anesthetic cost , and hospital stay were compared between the two groups .", "sentence_id": 3}
+{"abstract_id": "25358059", "label": "results", "text": "A total of @ patients randomized to CSEA ( @ ) or GA ( @ ) completed the study .", "sentence_id": 4}
+{"abstract_id": "25358059", "label": "results", "text": "In the CSEA group , each procedure was completed and there was no anesthetic conversion .", "sentence_id": 5}
+{"abstract_id": "25358059", "label": "results", "text": "Although based on the prospective randomized method , the GA group still had a little larger stone size ( p = @ ) and more multiple caliceal stones ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25358059", "label": "results", "text": "Overall , there were no statistically significant differences in operative time ( p = @ ) , stone fragmentation time ( p = @ ) , postoperative VAS pain score at @ and @ hours ( p = @ , @ ) , incidence of complications ( p = @ ) , stone-free rate ( p = @ ) , and hospital stays ( p = @ ) between the two groups .", "sentence_id": 7}
+{"abstract_id": "25358059", "label": "results", "text": "The patients in the GA group experienced a higher mean hemoglobin drop ( @ vs @ g/L , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25358059", "label": "results", "text": "In addition , the anesthetic cost was much cheaper in the CSEA group ( @ vs @ dollars , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25358059", "label": "conclusions", "text": "RIRS with CSEA can be completed with no anesthetic conversions and with the same efficacy and safety compared with GA. .", "sentence_id": 10}
+{"abstract_id": "25358059", "label": "conclusions", "text": "When considering economical aspects , CSEA appears to be a preferable alternative to GA for the patient whose general health status permits it .", "sentence_id": 11}
+{"abstract_id": "24465425", "label": "background", "text": "Progesterone is effective treatment for hot flushes/night sweats .", "sentence_id": 0}
+{"abstract_id": "24465425", "label": "background", "text": "The cardiovascular effects of progesterone therapy are unknown but evidence suggests that premenopausal normal estradiol with also normal progesterone levels may provide later cardiovascular protection .", "sentence_id": 1}
+{"abstract_id": "24465425", "label": "background", "text": "We compared the effects of progesterone to placebo on endothelial function , weight , blood pressure , metabolism , lipids , inflammation and coagulation .", "sentence_id": 2}
+{"abstract_id": "24465425", "label": "results", "text": "We conducted a randomized , double-blind , @-month placebo-controlled trial of progesterone ( @ mg daily ) among @ healthy postmenopausal women in Vancouver , Canada from @-@ .", "sentence_id": 3}
+{"abstract_id": "24465425", "label": "results", "text": "Endothelial function by venous occlusion plethysmography was a planned primary outcome .", "sentence_id": 4}
+{"abstract_id": "24465425", "label": "results", "text": "Enrolled women were @-@ y since last menstruation , not using hormones ( for > @ months ) , non-smoking , without diabetes , hypertension , heart disease or their medications .", "sentence_id": 5}
+{"abstract_id": "24465425", "label": "results", "text": "Randomized ( @ ) women ( @ @ years , body mass index @ @ ) initially had normal blood pressure , fasting lipid , glucose and electrocardiogram results .", "sentence_id": 6}
+{"abstract_id": "24465425", "label": "results", "text": "Endothelial function ( % forearm blood flow above saline ) was not changed with progesterone ( @ @ % , n = @ ) compared with placebo ( @ @ % , n = @ ) ( @ % CI diff -LSB- -@ to @ -RSB- , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24465425", "label": "results", "text": "Progesterone ( n = @ ) and placebo ( n = @ ) groups had similar changes in systolic and diastolic blood pressure , resting heart rate , weight , body mass index , waist circumference , total cholesterol , low-density lipoprotein cholesterol and triglyceride levels .", "sentence_id": 8}
+{"abstract_id": "24465425", "label": "results", "text": "High-density lipoprotein was lower ( -@ mmol/L , P = @ ) on progesterone compared with placebo .", "sentence_id": 9}
+{"abstract_id": "24465425", "label": "results", "text": "Fasting glucose , hs-C-reactive protein , albumin and D-dimer changes were all comparable to placebo .", "sentence_id": 10}
+{"abstract_id": "24465425", "label": "results", "text": "Framingham General Cardiovascular Risk Profile scores were initially low and remained low with progesterone therapy and not statistically different from placebo .", "sentence_id": 11}
+{"abstract_id": "24465425", "label": "conclusions", "text": "Results indicate that progesterone has short-term cardiovascular safety .", "sentence_id": 12}
+{"abstract_id": "24465425", "label": "conclusions", "text": "Endothelial function , weight , blood pressure , waist circumference , inflammation and coagulation were unchanged as were lipids except for HDL-C .", "sentence_id": 13}
+{"abstract_id": "24465425", "label": "conclusions", "text": "The statistically significant decrease in HDL-C levels was not clinically important ( based on lack of Cardiovascular Risk Profile change ) .", "sentence_id": 14}
+{"abstract_id": "25315498", "label": "background", "text": "Fluralaner ( Bravecto ; Merck/MSD Animal Health ) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose .", "sentence_id": 0}
+{"abstract_id": "25315498", "label": "background", "text": "Milbemycin oxime and praziquantel are routinely used to control Dirofilaria immitis and intestinal worm infections in dogs .", "sentence_id": 1}
+{"abstract_id": "25315498", "label": "background", "text": "The safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet , in particular with regard to gastrointestinal symptoms , was investigated using oral doses at or above the maximum recommended rates .", "sentence_id": 2}
+{"abstract_id": "25315498", "label": "results", "text": "Some minor and transient clinical findings were observed during the study period ; however , none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel , or to the use of either product alone .", "sentence_id": 3}
+{"abstract_id": "25315498", "label": "conclusions", "text": "Concurrent treatment with fluralaner , milbemycin oxime and praziquantel is well tolerated in dogs .", "sentence_id": 4}
+{"abstract_id": "24941286", "label": "objective", "text": "Afterschool programs can be health-promoting environments for children .", "sentence_id": 0}
+{"abstract_id": "24941286", "label": "objective", "text": "Written policies positively influence nutrition and physical activity ( PA ) environments , but effective strategies for building staff capacity to write such policies have not been evaluated .", "sentence_id": 1}
+{"abstract_id": "24941286", "label": "objective", "text": "This study measures the comprehensiveness of written nutrition , PA , and screen time policies in afterschool programs and assesses impact of the Out of School Nutrition and Physical Activity ( OSNAP ) intervention on key policies .", "sentence_id": 2}
+{"abstract_id": "24941286", "label": "methods", "text": "Twenty afterschool programs in Boston , MA participated in a group-randomized , controlled trial from September @ to June @ .", "sentence_id": 3}
+{"abstract_id": "24941286", "label": "methods", "text": "Intervention program staff attended learning collaboratives focused on practice and policy change .", "sentence_id": 4}
+{"abstract_id": "24941286", "label": "methods", "text": "The Out-of-School Time ( OST ) Policy Assessment Index evaluated written policies .", "sentence_id": 5}
+{"abstract_id": "24941286", "label": "methods", "text": "Inter-rater reliability and construct validity of the measure and impact of the intervention on written policies were assessed .", "sentence_id": 6}
+{"abstract_id": "24941286", "label": "results", "text": "The measure demonstrated moderate to excellent inter-rater reliability ( Spearman 's r = @ to @ ) and construct validity .", "sentence_id": 7}
+{"abstract_id": "24941286", "label": "results", "text": "OSNAP was associated with significant increases in standards-based policy statements surrounding snacks ( +@ , p = @ ) , beverages ( +@ , p = @ ) , screen time ( +@ , p = @ ) , family communication ( +@ , p = @ ) , and a summary index of OSNAP goals ( +@ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24941286", "label": "conclusions", "text": "OSNAP demonstrated success in building staff capacity to write health-promoting policy statements .", "sentence_id": 9}
+{"abstract_id": "24941286", "label": "conclusions", "text": "Future research should focus on determining policy change impact on practices .", "sentence_id": 10}
+{"abstract_id": "24424074", "label": "objective", "text": "Nut consumption has been found to decrease risk of coronary heart disease and diabetes and to promote healthy body weights possibly related to their favorable macronutrient profile .", "sentence_id": 0}
+{"abstract_id": "24424074", "label": "objective", "text": "We therefore assessed the effect of pistachios on postprandial glucose and insulin levels , gut hormones related to satiety and endothelial function .", "sentence_id": 1}
+{"abstract_id": "24424074", "label": "methods", "text": "In this randomized crossover study , @ subjects with metabolic syndrome consumed five study meals over @-@ weeks .", "sentence_id": 2}
+{"abstract_id": "24424074", "label": "methods", "text": "The meals differed in fat type and quantity , but were matched according to available carbohydrates ( CHOs ) .", "sentence_id": 3}
+{"abstract_id": "24424074", "label": "methods", "text": "Three meals had @ g available CHO : white bread ( WB@g ) , white bread , butter and cheese ( WB+B+C h ) and white bread and pistachios ( WB+P ) .", "sentence_id": 4}
+{"abstract_id": "24424074", "label": "methods", "text": "Two meals had @ g available CHO : white bread ( WB@g ) and pistachios ( P ) .", "sentence_id": 5}
+{"abstract_id": "24424074", "label": "results", "text": "Within each group of available CHO meals , postprandial glucose levels were the highest following the white bread-only meals , and glucose response was significantly attenuated when butter and cheese or pistachios were consumed ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24424074", "label": "results", "text": "Postprandial insulin levels were highest after the WB+B+C h meal ( P < @ ) , but did not differ between the white bread-only and pistachio meals .", "sentence_id": 7}
+{"abstract_id": "24424074", "label": "results", "text": "Both endothelial function ( reactive hyperemia index ) and arterial stiffness ( augmentation index ) significantly increased after the white bread-only meals compared with the WB+B+C h meal ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24424074", "label": "results", "text": "Insulin secretagogue levels were higher when butter and cheese or pistachios were consumed than when white bread only was consumed ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24424074", "label": "conclusions", "text": "Compared with white bread , pistachio consumption reduced postprandial glycemia , increased glucagon-like-peptide levels and may have insulin-sparing properties .", "sentence_id": 10}
+{"abstract_id": "24424074", "label": "conclusions", "text": "These effects could be beneficial for individuals with diabetes and metabolic syndrome .", "sentence_id": 11}
+{"abstract_id": "26125443", "label": "background", "text": "Bevacizumab prolongs progression-free survival ( PFS ) in patients with metastatic colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "26125443", "label": "background", "text": "We analysed the protein expression levels of vascular endothelial growth factor ( VEGF ) ligands and receptors to determine their prognostic and predictive effects .", "sentence_id": 1}
+{"abstract_id": "26125443", "label": "methods", "text": "We graded expression of VEGF-A , VEGF-B , VEGF-C , VEGF-D , VEGF-R@ , and VEGF-R@ to assess whether overexpression predicted bevacizumab resistance in samples from @ of @ patients randomised to capecitabine ( C ) , capecitabine and bevacizumab ( CB ) , or CB and mitomycin ( CBM ) in the MAX trial and extended the analysis to the CAIRO-@ population .", "sentence_id": 2}
+{"abstract_id": "26125443", "label": "results", "text": "Patients with low expression of VEGF-D ( @ , @ ) benefited from bevacizumab treatment ( PFS hazard ratio ( HR ) ( C vs CBCBM ) , @ ; @ % CI , @ ; overall survival ( OS ) HR , @ ; @ % CI , @ ) .", "sentence_id": 3}
+{"abstract_id": "26125443", "label": "results", "text": "Patients with higher VEGF-D expression received less benefit ( VEGF-D @ PFS HR , @ ; @ % CI , @ ; OS HR , @ ; @ % CI , @ ; VEGF-D @ PFS HR , @ ; @ % CI , @ ; OS HR , @ ; @ % CI , @ ) ( P interaction o@ @ ) .", "sentence_id": 4}
+{"abstract_id": "26125443", "label": "results", "text": "In CAIRO-@ , there was no difference in PFS or OS according to VEGF-D expression .", "sentence_id": 5}
+{"abstract_id": "26125443", "label": "conclusions", "text": "The predictive value of VEGF-D expression for bevacizumab may depend on the chemotherapy backbone used .", "sentence_id": 6}
+{"abstract_id": "26125443", "label": "conclusions", "text": "Further evaluation is required before clinical utilisation .", "sentence_id": 7}
+{"abstract_id": "25122186", "label": "background", "text": "Abnormalities in cardiac structure and function in heart failure with preserved ejection fraction may help identify patients at particularly high risk for cardiovascular morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "25122186", "label": "results", "text": "Cardiac structure and function were assessed by echocardiography in a blinded core laboratory at baseline in @ patients with heart failure with preserved ejection fraction ( left ventricular ejection fraction @ % ) enrolled in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist ( TOPCAT ) trial and related to the primary composite outcome of cardiovascular death , heart failure hospitalization , or aborted cardiac arrest , and its components .", "sentence_id": 1}
+{"abstract_id": "25122186", "label": "results", "text": "At a median follow-up of @ years , @ patients experienced the primary outcome .", "sentence_id": 2}
+{"abstract_id": "25122186", "label": "results", "text": "Left ventricular hypertrophy ( adjusted hazard ratio , @ ; @ % confidence interval , @-@ @ ) , elevated left ventricular filling pressure ( E/E ' ; adjusted hazard ratio @ per @ integer increase ; @ % confidence interval , @-@ @ ) , and higher pulmonary artery pressure assessed by the tricuspid regurgitation velocity ( hazard ratio , @ per @ m/s increase ; @ % confidence interval , @-@ @ ) were associated with the composite outcome and heart failure hospitalization alone after adjusting for clinical and laboratory variables .", "sentence_id": 3}
+{"abstract_id": "25122186", "label": "results", "text": "The risk of adverse outcome associated with left ventricular hypertrophy was additive to the risk associated with elevated E/E ' .", "sentence_id": 4}
+{"abstract_id": "25122186", "label": "conclusions", "text": "Among heart failure with preserved ejection fraction patients enrolled in TOPCAT , left ventricular hypertrophy , higher left ventricular filling pressure , and higher pulmonary artery pressure were predictive of heart failure hospitalization , cardiovascular death , or aborted cardiac arrest independent of clinical and laboratory predictors .", "sentence_id": 5}
+{"abstract_id": "25122186", "label": "conclusions", "text": "These features , both alone and in combination , identify heart failure with preserved ejection fraction patients at particularly high risk for cardiovascular morbidity and mortality .", "sentence_id": 6}
+{"abstract_id": "25376940", "label": "background", "text": "The clinical benefits of bioimpedance spectroscopy ( BIS ) - guided fluid management in patients on hemodialysis have been widely demonstrated .", "sentence_id": 0}
+{"abstract_id": "25376940", "label": "background", "text": "However , no previous reports have evaluated the effect of regular and serial BIS-guided fluid management on the residual renal function ( RRF ) in patients on peritoneal dialysis ( PD ) .", "sentence_id": 1}
+{"abstract_id": "25376940", "label": "background", "text": "Therefore , we will evaluate the clinical efficacy of BIS-guided fluid management for preserving RRF and protecting cardiovascular events in patients on PD .", "sentence_id": 2}
+{"abstract_id": "25376940", "label": "methods", "text": "This is a multicenter , prospective , randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "25376940", "label": "methods", "text": "A total of @ participants on PD will be enrolled and randomly assigned to receive either BIS-guided fluid management or fluid management based only on the clinical information for @ year .", "sentence_id": 4}
+{"abstract_id": "25376940", "label": "methods", "text": "The primary outcome is the change in the glomerular filtration rate ( GFR ) between months @ and @ after starting treatment .", "sentence_id": 5}
+{"abstract_id": "25376940", "label": "methods", "text": "The secondary outcomes will include GFR at month @ , time to the anuric state ( urine volume < @ ml/day ) , and fatal and nonfatal cardiovascular events during treatment .", "sentence_id": 6}
+{"abstract_id": "25376940", "label": "conclusions", "text": "This is the first clinical trial to investigate the effect of BIS-guided fluid management on RRF and for protecting against cardiovascular events in patients on PD .", "sentence_id": 7}
+{"abstract_id": "24307845", "label": "objective", "text": "This study was performed to compare the mucosal findings after esophagogastroduodenoscopy in two groups before and after the use of alendronate only and following administration of the enteric-coated alendronate ( @ mg ) and calcitriol ( @ g ) combined drug ( Maxmarvil , Yuyu Co. ) .", "sentence_id": 0}
+{"abstract_id": "24307845", "label": "methods", "text": "The study population consisted of @ postmenopausal healthy female volunteers , aged @ to @ years ( mean age , @ @ ) without gastrointestinal symptoms and with normal baseline endoscopic findings .", "sentence_id": 1}
+{"abstract_id": "24307845", "label": "methods", "text": "Esophagogastroduodenoscopy was performed at baseline and was repeated @ weeks later after daily intake of Maxmarvil ( n = @ subjects ) or alendronate only ( n = @ subjects ) .", "sentence_id": 2}
+{"abstract_id": "24307845", "label": "methods", "text": "Mucosal injury scores were reported by an endoscopist after @ weeks of treatment with each medication schedule .", "sentence_id": 3}
+{"abstract_id": "24307845", "label": "results", "text": "Esophageal mucosal injuries developed in two of @ subjects in the alendronate only group and @ of @ in the Maxmarvil group .", "sentence_id": 4}
+{"abstract_id": "24307845", "label": "results", "text": "Gastric mucosal injuries developed in eight subjects in the alendronate group and four subjects in the Maxmarvil group ; this difference was statistically significant .", "sentence_id": 5}
+{"abstract_id": "24307845", "label": "conclusions", "text": "The mucosal damage scores for the alendronate group ( total score @ ) were significantly higher than those for the Maxmarvil group ( total score @ ) in the esophagus and stomach .", "sentence_id": 6}
+{"abstract_id": "24307845", "label": "conclusions", "text": "Therefore , this study suggested that enteric-coated Maxmarvil is less harmful to gastrointestinal mucosa than alendronate , and may improve the tolerability of osteoporosis medication in clinical practice .", "sentence_id": 7}
+{"abstract_id": "24723432", "label": "objective", "text": "Although antidepressant drugs are used as first-line intervention to treat patients with generalized anxiety disorder ( GAD ) , only one-third of patients respond positively to treatment .", "sentence_id": 0}
+{"abstract_id": "24723432", "label": "objective", "text": "In our study , we investigated whether functional genetic polymorphisms in the dopamine active transporter @ ( DAT@ ) and dopamine receptor D@ ( DRD@ ) may play a role in antidepressant treatment response in GAD .", "sentence_id": 1}
+{"abstract_id": "24723432", "label": "methods", "text": "We examined @ patients diagnosed with GAD who received venlafaxine Extended-Release ( XR ) treatment as part of an @-month relapse-prevention study to determine whether variation in these genes had an effect on treatment response after @months of open-label treatment .", "sentence_id": 2}
+{"abstract_id": "24723432", "label": "methods", "text": "Genotypes were obtained for rs@ ( DRD@ ) , rs@ ( DRD@ ) , rs@ ( DAT@ ) , and a variable number tandem repeat in the @ ' untranslated region of the DAT@ gene using standard methods .", "sentence_id": 3}
+{"abstract_id": "24723432", "label": "results", "text": "Results show that none of the tested variants were associated with treatment response to venlafaxine XR in GAD .", "sentence_id": 4}
+{"abstract_id": "24723432", "label": "results", "text": "Genotype and allele frequencies did not differ statistically significantly between responders and non-responders using either the Hamilton Anxiety or Clinical Global Impressions of Improvement Scale at @months .", "sentence_id": 5}
+{"abstract_id": "24723432", "label": "conclusions", "text": "Although we detected no association in our sample , future studies using larger samples and more comprehensive gene coverage are needed to evaluate potential effects of dopaminergic variants on antidepressant treatment response in anxiety disorders .", "sentence_id": 6}
+{"abstract_id": "24419415", "label": "background", "text": "In non-small-cell lung cancer , an exon @ deletion and an L@R point mutation in the epidermal growth factor receptor ( EGFR ) are predictors of a response to EGFR-tyrosine kinase inhibitors .", "sentence_id": 0}
+{"abstract_id": "24419415", "label": "background", "text": "However , it is uncertain whether other uncommon EGFR mutations are associated with sensitivity to EGFR-tyrosine kinase inhibitors .", "sentence_id": 1}
+{"abstract_id": "24419415", "label": "methods", "text": "A post-hoc analysis to assess prognostic factors was performed with the use of patients with EGFR mutations ( exon @ deletion , L@R , G@X , and L@Q ) who were treated with gefitinib in the NEJ@ study , which compared gefitinib with carboplatin-paclitaxel as the first-line therapy .", "sentence_id": 2}
+{"abstract_id": "24419415", "label": "results", "text": "In the NEJ@ study , @ patients with EGFR mutations received gefitinib at any treatment line .", "sentence_id": 3}
+{"abstract_id": "24419415", "label": "results", "text": "The Cox proportional hazards model indicated that performance status , response to chemotherapy , response to gefitinib , and mutation types were significant prognostic factors .", "sentence_id": 4}
+{"abstract_id": "24419415", "label": "results", "text": "Overall survival ( OS ) was significantly shorter among patients with uncommon EGFR mutations ( G@X or L@Q ) compared with OS of those with common EGFR mutations ( @ versus @ months ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24419415", "label": "results", "text": "In the gefitinib group ( n = @ ) , patients with uncommon EGFR mutations had a significantly shorter OS ( @ versus @ months ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24419415", "label": "results", "text": "By contrast , OS was similar between patients with uncommon mutations and those with common mutations in the carboplatin-paclitaxel group ( n = @ ; @ versus @ months ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24419415", "label": "conclusions", "text": "The post-hoc analyses clearly demonstrated shorter survival for gefitinib-treated patients with uncommon EGFR mutations compared with the survival of those with common mutations and suggest that the first-line chemotherapy may be relatively effective for non-small-cell lung cancer with uncommon EGFR mutations .", "sentence_id": 8}
+{"abstract_id": "24628999", "label": "objective", "text": "To compare refractive changes after corneal crosslinking with and without mechanical compression of the cornea .", "sentence_id": 0}
+{"abstract_id": "24628999", "label": "methods", "text": "In a prospective , open , randomized case-control study conducted at the Department of Ophthalmology , Ume University Hospital , Sweden , sixty eyes of @ patients with progressive keratoconus aged @-@ years planned for corneal crosslinking and corresponding age - and sex-matched control subjects were included .", "sentence_id": 1}
+{"abstract_id": "24628999", "label": "methods", "text": "The patients were randomized to conventional corneal crosslinking ( CXL ; n = @ ) or corneal crosslinking with mechanical compression using a flat rigid contact lens sutured to the cornea during treatment ( CRXL ; n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24628999", "label": "methods", "text": "Subjective refraction and ETDRS best spectacle-corrected visual acuity ( BSCVA ) , axial length measurement , keratometry and pachymetry were performed before and @ and @ months after treatment .", "sentence_id": 3}
+{"abstract_id": "24628999", "label": "results", "text": "The keratoconus patients had poorer BSCVA , higher refractive astigmatism and higher keratometry readings than the control subjects at baseline ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24628999", "label": "results", "text": "In the CXL group , BSCVA increased from @ @ to @ @ logMar ( p = @ ) , and the spherical equivalent improved from -@ @ D to -@ @ D ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24628999", "label": "results", "text": "Maximum keratometry readings decreased after CXL from @ @ D to @ @ D ( p = @ ) , and the axial length decreased in the CXL group , likely due to post-treatment corneal thinning ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24628999", "label": "results", "text": "In the CRXL group , all the above variables were unaltered ( p > @ ) .", "sentence_id": 7}
+{"abstract_id": "24628999", "label": "conclusions", "text": "At @ months , the refractive results from CRXL did not surpass those of conventional CXL treatment .", "sentence_id": 8}
+{"abstract_id": "24628999", "label": "conclusions", "text": "Rather , some variables indicated a slightly inferior effect .", "sentence_id": 9}
+{"abstract_id": "24628999", "label": "conclusions", "text": "Possibly , stronger crosslinking would be necessary to stabilize the cornea in the flattened configuration achieved by the rigid contact lens .", "sentence_id": 10}
+{"abstract_id": "24841107", "label": "background", "text": "Although coexisting obstructive sleep apnea ( OSA ) and Cheyne-Stokes respiration ( CSR ) occur frequently in patients with heart diseases , optimal treatment remains unclear .", "sentence_id": 0}
+{"abstract_id": "24841107", "label": "background", "text": "Positive airway pressure ( PAP ) effectively treats OSA and adaptive servo-ventilation ( ASV ) has been shown to improve CSR .", "sentence_id": 1}
+{"abstract_id": "24841107", "label": "background", "text": "We compared a new treatment algorithm combining automatic continuous positive airway pressure ( APAP ) and ASV ( anticyclic modulated ventilation , ACMV ) versus continuous positive airway pressure ( CPAP ) .", "sentence_id": 2}
+{"abstract_id": "24841107", "label": "methods", "text": "Thirty-nine patients ( @ male , four female ; aged @ years ; body mass index , @ kg/m@ ) with underlying heart disease and coexisting OSA and CSR were enrolled .", "sentence_id": 3}
+{"abstract_id": "24841107", "label": "methods", "text": "After diagnostic polysomnography ( PSG ) and CPAP titration , patients were randomized either to CPAP or to ACMV for four weeks of treatment in a crossover design .", "sentence_id": 4}
+{"abstract_id": "24841107", "label": "results", "text": "Total apnea-hypopnea index ( AHI ) was @ / h at baseline , @ / h with CPAP ( P < @ vs baseline ) , and @ / h with ACMV ( P < @ vs. baseline and vs. CPAP ) .", "sentence_id": 5}
+{"abstract_id": "24841107", "label": "results", "text": "Obstructive AHI was @ / h at baseline , @ / h with CPAP ( P < @ vs. baseline ) , and @ / h with ACMV ( P < @ vs. baseline and vs. CPAP ) .", "sentence_id": 6}
+{"abstract_id": "24841107", "label": "results", "text": "Central AHI was @ / h at baseline , @ / h with CPAP ( P < @ vs baseline ) and @ / h with ACMV ( P < @ vs. baseline and vs. CPAP ) .", "sentence_id": 7}
+{"abstract_id": "24841107", "label": "results", "text": "Ejection fraction was increased significantly ( from @ to @ % ) only with ACMV .", "sentence_id": 8}
+{"abstract_id": "24841107", "label": "results", "text": "Subjective sleepiness significantly improved only with CPAP whereas objective sleep quality and treatment adherence were not different between both treatment modalities .", "sentence_id": 9}
+{"abstract_id": "24841107", "label": "conclusions", "text": "ACMV is an effective treatment option in patients with coexisting OSA and CSR .", "sentence_id": 10}
+{"abstract_id": "24841107", "label": "conclusions", "text": "It is superior to CPAP in reducing total AHI as well as obstructive and central AHI .", "sentence_id": 11}
+{"abstract_id": "25098819", "label": "background", "text": "HER@ and TOP@A gene status are assessed for diagnostic and research purposes in breast cancer with fluorescence in situ hybridization ( FISH ) .", "sentence_id": 0}
+{"abstract_id": "25098819", "label": "background", "text": "However , FISH probes do not target only the annotated gene , while chromosome @ ( chr@ ) is among the most unstable chromosomes in breast cancer .", "sentence_id": 1}
+{"abstract_id": "25098819", "label": "background", "text": "Here we asked whether the status of specifically targeted genes on chr@ might help in refining prognosis of early high-risk breast cancer patients .", "sentence_id": 2}
+{"abstract_id": "25098819", "label": "methods", "text": "Copy numbers ( CN ) for @ genes on chr@ , @ of which were within and @ outside the core HER@ amplicon ( HER@ - and non-HER@-genes , respectively ) were assessed with qPCR in @ paraffin-embedded tumor tissue samples from breast cancer patients treated with adjuvant chemotherapy in the frame of two randomized phase III trials .", "sentence_id": 3}
+{"abstract_id": "25098819", "label": "results", "text": "HER@-genes CN strongly correlated to each other ( Spearman 's rho > @ ) and were concordant with FISH HER@ status ( Kappa @ for ERBB@ CN ) .", "sentence_id": 4}
+{"abstract_id": "25098819", "label": "results", "text": "TOP@A CN were not concordant with TOP@A FISH status ( Kappa @ ) .", "sentence_id": 5}
+{"abstract_id": "25098819", "label": "results", "text": "CN hierarchical clustering revealed distinct patterns of gains , losses and complex alterations in HER@ - and non-HER@-genes associated with IHC@ breast cancer subtypes .", "sentence_id": 6}
+{"abstract_id": "25098819", "label": "results", "text": "Upon multivariate analysis , non-HER@-gene gains independently predicted for shorter disease-free survival ( DFS ) and overall survival ( OS ) in patients with triple-negative cancer , as compared to luminal and HER@-positive tumors ( interaction p = @ for DFS and p = @ for OS ) .", "sentence_id": 7}
+{"abstract_id": "25098819", "label": "results", "text": "Similarly , non-HER@-gene gains were associated with worse prognosis in patients who had undergone breast-conserving surgery as compared to modified radical mastectomy ( p = @ for both DFS and OS ) .", "sentence_id": 8}
+{"abstract_id": "25098819", "label": "results", "text": "Non-HER@-gene losses were unfavorable prognosticators in patients with @-@ metastatic nodes , as compared to those with @ or more nodes ( p = @ for DFS and p = @ for OS ) .", "sentence_id": 9}
+{"abstract_id": "25098819", "label": "conclusions", "text": "TOP@A FISH and qPCR may not identify the same pathology on chr@q .", "sentence_id": 10}
+{"abstract_id": "25098819", "label": "conclusions", "text": "Non-HER@ chr@ CN patterns may further predict outcome in breast cancer patients with known favorable and unfavorable prognosis .", "sentence_id": 11}
+{"abstract_id": "24225201", "label": "background", "text": "Heart failure ( HF ) and chronic obstructive pulmonary disease ( COPD ) frequently coexist , with undefined prognostic and therapeutic implications .", "sentence_id": 0}
+{"abstract_id": "24225201", "label": "background", "text": "We investigated clinical profile and outcomes of patients with chronic HF and COPD , notably the efficacy and safety of ivabradine , a heart rate-reducing agent .", "sentence_id": 1}
+{"abstract_id": "24225201", "label": "methods", "text": "@ ambulatory patients , in sinus rhythm , heart rate @ bpm and stable systolic HF were randomised to placebo or ivabradine ( @ to @ mg bid ) .", "sentence_id": 2}
+{"abstract_id": "24225201", "label": "methods", "text": "Multivariate Cox model analyses were performed to compare the COPD ( n = @ ) and non-COPD subgroups , and the ivabradine and placebo treatment effects .", "sentence_id": 3}
+{"abstract_id": "24225201", "label": "results", "text": "COPD patients were older and had a poorer risk profile .", "sentence_id": 4}
+{"abstract_id": "24225201", "label": "results", "text": "Beta-blockers were prescribed to @ % of COPD patients and @ % of non-COPD patients .", "sentence_id": 5}
+{"abstract_id": "24225201", "label": "results", "text": "The primary endpoint ( PEP ) and its component , hospitalisation for worsening HF , were more frequent in COPD patients ( HRs f , @ -LSB- p = @ -RSB- ; and @ -LSB- p < @ -RSB- ) respectively , but relative risk was reduced similarly by ivabradine in both COPD ( @ % , and @ % ) and non-COPD ( @ % and @ % ) patients ( p interaction = @ , and @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "24225201", "label": "results", "text": "Similar effect was noted also for cardiovascular death .", "sentence_id": 7}
+{"abstract_id": "24225201", "label": "results", "text": "Adverse events were more common in COPD patients , but similar in treatment subgroups .", "sentence_id": 8}
+{"abstract_id": "24225201", "label": "results", "text": "Bradycardia occurred more frequently in ivabradine subgroups , with similar incidence in patients with or without COPD .", "sentence_id": 9}
+{"abstract_id": "24225201", "label": "conclusions", "text": "The association of COPD and HF results in a worse prognosis , and COPD represents a barrier to optimisation of beta-blocker therapy .", "sentence_id": 10}
+{"abstract_id": "24225201", "label": "conclusions", "text": "Ivabradine is similarly effective and safe in chronic HF patients with or without COPD , and can be safely combined with beta-blockers in COPD .", "sentence_id": 11}
+{"abstract_id": "24590419", "label": "objective", "text": "Although several eating disorder prevention programs reduce eating disorder risk factors and symptoms for female high school and college students , few efficacious prevention programs exist for female middle school students , despite the fact that body image and eating disturbances often emerge then .", "sentence_id": 0}
+{"abstract_id": "24590419", "label": "objective", "text": "Two pilot trials evaluated a new dissonance-based eating disorder prevention program for middle school girls with body image concerns .", "sentence_id": 1}
+{"abstract_id": "24590419", "label": "methods", "text": "Female middle school students with body dissatisfaction from two sites -LSB- Study @ : N = @ , M age = @ , standard deviation ( SD ) = @ ; Study @ : N = @ , M age = @ , SD = @ -RSB- were randomized to a dissonance intervention ( MS Body Project ) or educational brochure control ; Study @ included a @-month follow-up .", "sentence_id": 2}
+{"abstract_id": "24590419", "label": "results", "text": "Intervention participants showed significant post-test reductions in only one of the six variables with both Studies @ and @ ( i.e. , pressure to be thin and negative affect , respectively ) , though post-test effect sizes suggested medium reductions in eating disorder risk factors and symptoms ( Study @ : M d = @ ; Study @ : M d = @ ) ; reductions at @-month follow-up in Study @ were not evident ( M d = @ ) .", "sentence_id": 3}
+{"abstract_id": "24590419", "label": "conclusions", "text": "Results suggest that this new middle school version of the Body Project is producing medium magnitude reductions in eating disorder risk factors at post-test but that effects are showing limited persistence .", "sentence_id": 4}
+{"abstract_id": "24590419", "label": "conclusions", "text": "Continued refinement and evaluation of this intervention appears warranted to develop more effective prevention programs for this age group .", "sentence_id": 5}
+{"abstract_id": "24809408", "label": "objective", "text": "The aim of this study is to evaluate the effect of oral glutamine ( GL ) supplementation on gut permeability and endotoxemia ( surrogate end point ) in patients with severe acute pancreatitis .", "sentence_id": 0}
+{"abstract_id": "24809408", "label": "methods", "text": "In a randomized controlled trial , patients were randomized to be given placebo or GL for @ days .", "sentence_id": 1}
+{"abstract_id": "24809408", "label": "methods", "text": "The primary outcome measures include the effect on gut permeability ( assessed by lactulose/mannitol excretion in urine and endotoxemia assessed by endotoxin core antibodies type IgG and IgM ( EndoCab IgG and IgM ) .", "sentence_id": 2}
+{"abstract_id": "24809408", "label": "methods", "text": "The secondary outcome measures include infectious complications , mortality , total hospital/intensive care unit stay , C-reactive protein , and prealbumin levels .", "sentence_id": 3}
+{"abstract_id": "24809408", "label": "results", "text": "Patients were assigned to GL ( n = @ ) and placebo ( n = @ ) groups .", "sentence_id": 4}
+{"abstract_id": "24809408", "label": "results", "text": "There was no change in gut permeability after the intervention .", "sentence_id": 5}
+{"abstract_id": "24809408", "label": "results", "text": "However , the EndoCab IgM levels increased significantly ( @ -LSB- @ , @ -RSB- to @ -LSB- @ , @ -RSB- GMU/mL ; P = @ ) and the C-reactive protein levels decreased significantly ( @ -LSB- @ , @ -RSB- to @ -LSB- @ , @ -RSB- ng/mL ; P = @ ) in the GL group .", "sentence_id": 6}
+{"abstract_id": "24809408", "label": "results", "text": "No difference was observed in infectious complication , prealbumin value , hospital/intensive care unit stay , and mortality in both groups .", "sentence_id": 7}
+{"abstract_id": "24809408", "label": "conclusions", "text": "No significant trend was identified for an effect of GL on gut permeability .", "sentence_id": 8}
+{"abstract_id": "24809408", "label": "conclusions", "text": "Decreased inflammation and endotoxemia did not translate into reduced infectious complications in severe acute pancreatitis .", "sentence_id": 9}
+{"abstract_id": "24809408", "label": "conclusions", "text": "However , the study was underpowered to detect the aforementioned difference ( trial registration : CTRI/@/@ ) .", "sentence_id": 10}
+{"abstract_id": "24713310", "label": "background", "text": "Tapentadol is an analgesic agent for treatment of acute and chronic pain that activates the - opioid receptor combined with inhibition of neuronal norepinephrine reuptake .", "sentence_id": 0}
+{"abstract_id": "24713310", "label": "background", "text": "Both mechanisms are implicated in activation of descending inhibitory pain pathways .", "sentence_id": 1}
+{"abstract_id": "24713310", "label": "background", "text": "In this study , we investigated the influence of tapentadol on conditioned pain modulation ( CPM , an experimental measure of endogenous pain inhibition that gates incoming pain signals as a consequence of a preceding tonic painful stimulus ) and offset analgesia ( OA , a test in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation ) .", "sentence_id": 2}
+{"abstract_id": "24713310", "label": "methods", "text": "Twenty-four patients with diabetic polyneuropathy ( DPN ) were randomized to receive daily treatment with tapentadol sustained-release ( SR ) -LSB- average daily dose @ ( @ ) mg -RSB- or placebo for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24713310", "label": "methods", "text": "CPM and OA were measured before and on the last day of treatment .", "sentence_id": 4}
+{"abstract_id": "24713310", "label": "results", "text": "Before treatment , none of the patients had significant CPM or OA responses .", "sentence_id": 5}
+{"abstract_id": "24713310", "label": "results", "text": "At week @ of treatment , CPM was significantly activated by tapentadol SR and coincided with significant analgesic responses .", "sentence_id": 6}
+{"abstract_id": "24713310", "label": "results", "text": "CPM increased from @ ( @ ) % ( baseline ) to @ ( @ ) % ( placebo ) and @ ( @ ) % ( tapentadol SR , P < @ vs placebo ) ; relief of DPN pain was also greater in patients treated with tapentadol than placebo ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24713310", "label": "results", "text": "Neither placebo nor tapentadol SR treatment had an effect on the magnitude of the OA responses ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24713310", "label": "conclusions", "text": "Tapentadol 's analgesic effect in chronic pain patients with DPN is dependent on activation of descending inhibitory pain pathways as observed by CPM responses .", "sentence_id": 9}
+{"abstract_id": "24548981", "label": "objective", "text": "To characterize the safety , tolerability , pharmacokinetics ( PK ) and dose proportionality of mipomersen after single subcutaneous ( SC ) administration to Japanese healthy subjects ; and to compare the PK profiles of Japanese and Western subjects .", "sentence_id": 0}
+{"abstract_id": "24548981", "label": "methods", "text": "@ healthy first-generation Japanese male subjects were enrolled into one of three treatment cohorts ( @ , @ and @ mg SC ) in a dose-escalation design .", "sentence_id": 1}
+{"abstract_id": "24548981", "label": "methods", "text": "Within each cohort , subjects were randomized in a @ : @ ratio to receive mipomersen or placebo .", "sentence_id": 2}
+{"abstract_id": "24548981", "label": "results", "text": "Mipomersen was absorbed rapidly after SC administration ; median tmax varied between @ and @ hours .", "sentence_id": 3}
+{"abstract_id": "24548981", "label": "results", "text": "After reaching peak levels , plasma concentrations of mipomersen decayed multiphasically with an initial distribution t@/@ in several hours and a terminal t@/@ of @ - @ hours .", "sentence_id": 4}
+{"abstract_id": "24548981", "label": "results", "text": "Mean Cmax increased in a dose-linear manner while all mean AUC from time @ to different cut points increased slightly more than dose proportionally .", "sentence_id": 5}
+{"abstract_id": "24548981", "label": "results", "text": "Although mean terminal t@/@ varied in the dose range tested , it did not show dose-dependence .", "sentence_id": 6}
+{"abstract_id": "24548981", "label": "results", "text": "The PK profiles of mipomersen in Japanese subjects are similar to those observed in Western subjects .", "sentence_id": 7}
+{"abstract_id": "24548981", "label": "results", "text": "A single SC dose of @ mg , @ mg and @ mg mipomersen was well tolerated by male Japanese subjects .", "sentence_id": 8}
+{"abstract_id": "24548981", "label": "conclusions", "text": "Single SC doses of @ - @ mg were safe and well tolerated when administered to Japanese subjects .", "sentence_id": 9}
+{"abstract_id": "24548981", "label": "conclusions", "text": "Comparison of PK between Japanese and Western subjects does not support any need for dose adjustment in Japanese population in future clinical development .", "sentence_id": 10}
+{"abstract_id": "25465680", "label": "background", "text": "The granisetron transdermal system ( GTS ) showed non-inferior efficacy to oral granisetron to control chemotherapy-induced nausea and vomiting ( CINV ) during multiday chemotherapy .", "sentence_id": 0}
+{"abstract_id": "25465680", "label": "background", "text": "We compared the efficacy and safety of GTS with that of intravenous and oral granisetron in Korean patients receiving moderately emetogenic chemotherapy ( MEC ) .", "sentence_id": 1}
+{"abstract_id": "25465680", "label": "methods", "text": "A total of @ patients were randomized into GTS ( n = @ , one patch on days @-@ ) or control group ( n = @ , intravenous on day @ and oral on days @-@ ) .", "sentence_id": 2}
+{"abstract_id": "25465680", "label": "methods", "text": "The primary endpoint was the percentage of patients achieving complete response ( CR ) from chemotherapy initiation until @ h after the final administration .", "sentence_id": 3}
+{"abstract_id": "25465680", "label": "results", "text": "Out of @ patients ( @ in GTS and @ in control group ) included in the per protocol analysis , @ % had gastrointestinal cancer and @ % received @-day chemotherapy .", "sentence_id": 4}
+{"abstract_id": "25465680", "label": "results", "text": "The GTS showed non-inferior efficacy achieving CR in @ % of the patients ; @ % of the patients in the control group achieved CR ( @ % confidence interval -@ to @ % ) .", "sentence_id": 5}
+{"abstract_id": "25465680", "label": "results", "text": "The CR rate did not change after subgroup analyses by sex , age , and chemotherapy naivety and analysis per day and overall days of treatment .", "sentence_id": 6}
+{"abstract_id": "25465680", "label": "results", "text": "The GTS group showed sustained CR from day @ to day @ .", "sentence_id": 7}
+{"abstract_id": "25465680", "label": "results", "text": "Patients ' satisfaction , assessed using Functional Living Index-Emesis ( FLI-E ) , showed no difference .", "sentence_id": 8}
+{"abstract_id": "25465680", "label": "results", "text": "Both treatments were well tolerated and safe .", "sentence_id": 9}
+{"abstract_id": "25465680", "label": "conclusions", "text": "The GTS showed non-inferior efficacy to intravenous and oral granisetron .", "sentence_id": 10}
+{"abstract_id": "25465680", "label": "conclusions", "text": "The safety , tolerability , and FLI-E scores of the GTS were comparable to those of control group .", "sentence_id": 11}
+{"abstract_id": "25465680", "label": "conclusions", "text": "The GTS offers a convenient alternative option for relieving CINV in patients receiving MEC .", "sentence_id": 12}
+{"abstract_id": "25225008", "label": "background", "text": "The Creighton Model FertilityCare System ( CrMS ) teaches women to identify days when intercourse is likely to result in pregnancy .", "sentence_id": 0}
+{"abstract_id": "25225008", "label": "background", "text": "We sought to assess the impact of the CrMS on time to pregnancy ( TTP ) , via per-cycle pregnancy rates ( fecundability ) .", "sentence_id": 1}
+{"abstract_id": "25225008", "label": "methods", "text": "We conducted a parallel randomised trial at the University of Utah School of Medicine , @-@ .", "sentence_id": 2}
+{"abstract_id": "25225008", "label": "methods", "text": "Women ages @-@ years , in a relationship of proven fertility , who desired to conceive , were block-randomised and stratified for age , with allocation concealment by opaque sequentially numbered sealed envelopes .", "sentence_id": 3}
+{"abstract_id": "25225008", "label": "methods", "text": "The control group received the advice to have intercourse @-@ times per week , and the intervention group received CrMS instruction .", "sentence_id": 4}
+{"abstract_id": "25225008", "label": "methods", "text": "All women were asked to begin trying to conceive starting the second cycle in the study and were followed actively up to seven cycles , without blinding of research personnel .", "sentence_id": 5}
+{"abstract_id": "25225008", "label": "methods", "text": "We calculated descriptive statistics and fecundability , and estimated Cox models for TTP .", "sentence_id": 6}
+{"abstract_id": "25225008", "label": "methods", "text": "( Clinicaltrials.gov NCT@ ) .", "sentence_id": 7}
+{"abstract_id": "25225008", "label": "results", "text": "There were @ women randomised : @ to the control group ( all analysed ) and @ to the CrMS group ( @ analysed ) .", "sentence_id": 8}
+{"abstract_id": "25225008", "label": "results", "text": "The adjusted hazard ratio for the influence of CrMS on TTP was @ -LSB- @ % confidence interval ( CI ) : @ , @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "25225008", "label": "results", "text": "Fecundability in cycles with intent to conceive was @ % in controls and @ % with CrMS ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25225008", "label": "results", "text": "By the first cycle , fecundability was @ % in controls , and @ % with CrMS ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25225008", "label": "results", "text": "No adverse events were reported .", "sentence_id": 12}
+{"abstract_id": "25225008", "label": "conclusions", "text": "We found no significant impact of CrMS on TTP or fecundability , but fewer of the women receiving CrMS conceived by the first cycle .", "sentence_id": 13}
+{"abstract_id": "25598270", "label": "background", "text": "Migraine is a highly disabling disease affecting a significant proportion of the Australian population .", "sentence_id": 0}
+{"abstract_id": "25598270", "label": "background", "text": "The methylenetetrahydrofolate reductase ( MTHFR ) C@T variant has been associated with increased levels of homocysteine and risk of migraine with aura ( MA ) .", "sentence_id": 1}
+{"abstract_id": "25598270", "label": "background", "text": "Folic acid ( FA ) , vitamin B@ , and B@ supplementation has been previously shown to reduce increased levels of homocysteine and decrease migraine symptoms .", "sentence_id": 2}
+{"abstract_id": "25598270", "label": "background", "text": "However , the influence of dietary folate intake on migraine has been unclear .", "sentence_id": 3}
+{"abstract_id": "25598270", "label": "background", "text": "The aim of the current study was to analyze the association of dietary folate intake in the form of dietary folate equivalent , FA , and total food folate ( TFF ) on migraine frequency , severity , and disability .", "sentence_id": 4}
+{"abstract_id": "25598270", "label": "methods", "text": "A cohort of @ adult females of Caucasian descent with MA was genotyped for the MTHFR C@T variant using restriction enzyme digestion .", "sentence_id": 5}
+{"abstract_id": "25598270", "label": "methods", "text": "Dietary folate information was collected from all participants and analyzed using the `` FoodWorks '' @ package .", "sentence_id": 6}
+{"abstract_id": "25598270", "label": "methods", "text": "Folate consumption was compared with migraine frequency , severity , and disability using linear regression .", "sentence_id": 7}
+{"abstract_id": "25598270", "label": "results", "text": "A significant inverse relation was observed between dietary folate equivalent ( R ( @ ) = @ , B = -@ , P = @ , @ % confidence interval -LSB- CI -RSB- -LSB- -@ , -@ -RSB- ) and FA ( R ( @ ) = @ , B = -@ , P = @ , @ % CI -LSB- -@ , -@ -RSB- ) consumption and migraine frequency .", "sentence_id": 8}
+{"abstract_id": "25598270", "label": "results", "text": "It was also observed that in individuals with the CC genotype for the MTHFR C@T variant , migraine frequency was significantly linked to FA consumption ( R ( @ ) = @ , B = -@ , P = @ , @ % CI -LSB- -@ , -@ -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "25598270", "label": "conclusions", "text": "The results from this study indicate that folate intake in the form of FA may influence migraine frequency in female MA sufferers .", "sentence_id": 10}
+{"abstract_id": "24573909", "label": "background", "text": "Electronic monitoring is recommended for accurate measurement of medication adherence but a possible limitation is that it may influence adherence .", "sentence_id": 0}
+{"abstract_id": "24573909", "label": "objective", "text": "To test the reactive effect of electronic monitoring in a randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24573909", "label": "methods", "text": "A total of @ adults with type @ diabetes and HbA@c @mmol/mol were randomized to receiving their main oral glucose lowering medication in electronic containers or standard packaging .", "sentence_id": 2}
+{"abstract_id": "24573909", "label": "methods", "text": "The primary outcomes were self-reported adherence measured with the MARS ( Medication Adherence Report Scale ; range @-@ ) and HbA@c at @weeks .", "sentence_id": 3}
+{"abstract_id": "24573909", "label": "results", "text": "Non-significantly higher adherence and lower HbA@c were observed in the electronic container group ( differences in means , adjusting for baseline value : MARS , @ -LSB- @ % CI -@ to @ , p = @ -RSB- ; HbA@c ( mmol/mol ) , -@ -LSB- -@ to @ , p = @ -RSB- ) .", "sentence_id": 4}
+{"abstract_id": "24573909", "label": "conclusions", "text": "Electronic containers may lead to a small increase in adherence but this potential limitation is outweighed by their advantages .", "sentence_id": 5}
+{"abstract_id": "24573909", "label": "conclusions", "text": "Our findings support electronic monitoring as the method of choice in research on medication adherence .", "sentence_id": 6}
+{"abstract_id": "24573909", "label": "conclusions", "text": "( Trial registration Current Controlled Trials ISRCT N@ ) .", "sentence_id": 7}
+{"abstract_id": "25343949", "label": "objective", "text": "High levels of fibroblast growth factor @ are associated with accelerated progression of CKD .", "sentence_id": 0}
+{"abstract_id": "25343949", "label": "objective", "text": "Whether high fibroblast growth factor @ levels also predict incident CKD is uncertain .", "sentence_id": 1}
+{"abstract_id": "25343949", "label": "methods", "text": "A prospective case-cohort study was conducted within the Action to Control Cardiovascular Risk in Diabetes Trial .", "sentence_id": 2}
+{"abstract_id": "25343949", "label": "methods", "text": "The analytic sample consisted of a random subcohort of @ patients with type @ diabetes without prevalent CKD at baseline , @ of whom developed incident CKD during follow-up , and @ additional patients with incident CKD outside the random subcohort .", "sentence_id": 3}
+{"abstract_id": "25343949", "label": "methods", "text": "The association between serum intact fibroblast growth factor @ and incident CKD , defined as the new onset of eGFR < @ ml/min per @ m ( @ ) that represented a @ % decrease from baseline in an individual with eGFR@ ml/min per @ m ( @ ) and no microalbuminuria ( < @ mg/g creatinine ) at baseline , was tested .", "sentence_id": 4}
+{"abstract_id": "25343949", "label": "results", "text": "The mean baseline eGFR in the random subcohort was @ ml/min per @ m ( @ ) .", "sentence_id": 5}
+{"abstract_id": "25343949", "label": "results", "text": "During a median follow-up of @ years , there was a total of @ patients with incident CKD .", "sentence_id": 6}
+{"abstract_id": "25343949", "label": "results", "text": "The median baseline fibroblast growth factor @ level was modestly higher among patients with incident CKD versus controls ( @ , interquartile range = @-@ @ versus @ , interquartile range = @-@ @ pg/ml ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25343949", "label": "results", "text": "Higher baseline fibroblast growth factor @ levels were associated with higher risk of incident CKD in unadjusted and demographics-adjusted models , but the effect was attenuated after additional adjustment for clinical risk factors and baseline eGFR ( hazard ratio per SD of natural log fibroblast growth factor @ , @ ; @ % confidence interval , @ to @ ) , which was the strongest predictor of incident CKD .", "sentence_id": 8}
+{"abstract_id": "25343949", "label": "results", "text": "Consistent with the results of primary analyses , baseline fibroblast growth factor @ was not associated with eGFR slope .", "sentence_id": 9}
+{"abstract_id": "25343949", "label": "conclusions", "text": "Higher fibroblast growth factor @ levels are not independently associated with higher risk of incident CKD in patients with type @ diabetes .", "sentence_id": 10}
+{"abstract_id": "24886098", "label": "background", "text": "Many commencing junior doctors worldwide feel ill-prepared to deal with their new responsibilities , particularly prescribing .", "sentence_id": 0}
+{"abstract_id": "24886098", "label": "background", "text": "Simulation has been widely utilised in medical education , but the use of extended multi-method simulation to emulate the junior doctor experience has rarely been reported .", "sentence_id": 1}
+{"abstract_id": "24886098", "label": "methods", "text": "A randomised controlled trial compared students who underwent two , week-long , extended simulations , several months apart ( Intervention ) , with students who attended related workshops and seminars alone ( Control ) , for a range of outcome measures .", "sentence_id": 2}
+{"abstract_id": "24886098", "label": "results", "text": "Eighty-four third year students in a graduate-entry medical program were randomised , and @ completed the study .", "sentence_id": 3}
+{"abstract_id": "24886098", "label": "results", "text": "At the end of the first week , Intervention students scored a mean of @ % on a prescribing test , compared with @ % for Control students ( P = @ ) and Intervention teams initiated cardiac compressions a mean of @ seconds into a resuscitation test scenario , compared with @ seconds for Control teams ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24886098", "label": "results", "text": "At the beginning of the second week , an average of nine months later , a significant difference was maintained in relation to the prescribing test only ( @ % vs @ % , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24886098", "label": "results", "text": "At the end of the second week , significant Intervention vs Control differences were seen on knowledge and reasoning tests , a further prescribing test ( @ % vs @ % -LSB- P < @ -RSB- ) and a paediatric resuscitation scenario test ( @ seconds to initiation of fluid resuscitation vs @ seconds -LSB- P = @ -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "24886098", "label": "conclusions", "text": "The study demonstrated long-term retention of improved prescribing skills , and an immediate effect on knowledge acquisition , reasoning and resuscitation skills , from contextualising learning activities through extended multi-method simulation .", "sentence_id": 7}
+{"abstract_id": "25038532", "label": "objective", "text": "Identify predictors of non-compliance with first round screening exams in the Prostate , Lung , Colorectal and Ovarian ( PLCO ) Cancer Screening Trial .", "sentence_id": 0}
+{"abstract_id": "25038532", "label": "methods", "text": "The PLCO was conducted from @ to @ at @ US institutions .", "sentence_id": 1}
+{"abstract_id": "25038532", "label": "methods", "text": "A total of @,@ healthy men and women ages @-@ years were randomized .", "sentence_id": 2}
+{"abstract_id": "25038532", "label": "methods", "text": "Intervention arm participants were invited to receive gender-appropriate screening exams for prostate , lung , colorectal and ovarian cancer .", "sentence_id": 3}
+{"abstract_id": "25038532", "label": "methods", "text": "Using intervention-arm data ( @,@ participants ) , non-compliance percentages for @ covariates were calculated , as were unadjusted and adjusted odds ratios ( ORs ) , and @ % confidence intervals .", "sentence_id": 4}
+{"abstract_id": "25038532", "label": "methods", "text": "Covariates included demographic factors as well as factors specific to PLCO ( e.g. , method of consent , distance from screening center ) .", "sentence_id": 5}
+{"abstract_id": "25038532", "label": "results", "text": "The rate of non-compliance was @ % overall but varied by screening center .", "sentence_id": 6}
+{"abstract_id": "25038532", "label": "results", "text": "Significant associations were observed for most covariates but indicated modest increases or decreases in odds .", "sentence_id": 7}
+{"abstract_id": "25038532", "label": "results", "text": "An exception was the use of a two-step consent process ( consented intervention arm participants for exams after randomization ) relative to a one-step process ( consented all participants prior to randomization ) ( OR : @ , @ % CI : @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25038532", "label": "results", "text": "Non-compliance percentages increased with further distance from screening centers , but ORs were not significantly different from @ .", "sentence_id": 9}
+{"abstract_id": "25038532", "label": "conclusions", "text": "Many factors modestly influenced compliance .", "sentence_id": 10}
+{"abstract_id": "25038532", "label": "conclusions", "text": "Consent process was the strongest predictor of compliance .", "sentence_id": 11}
+{"abstract_id": "24491874", "label": "background", "text": "Regular exercise is an effective intervention to decrease blood pressure ( BP ) in hypertension , but no data are available concerning the effects of heated water-based exercise ( HEx ) .", "sentence_id": 0}
+{"abstract_id": "24491874", "label": "background", "text": "This study examines the effects of HEx on BP in resistant hypertensive patients .", "sentence_id": 1}
+{"abstract_id": "24491874", "label": "methods", "text": "This is a parallel , randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "24491874", "label": "methods", "text": "@ nonconsecutive sedentary patients with resistant hypertension from a hypertension outpatient clinic in a university hospital were screened ; @ patients fulfilled the study requirements .", "sentence_id": 3}
+{"abstract_id": "24491874", "label": "methods", "text": "The training was performed for @-minute sessions in a heated pool ( @C ) , three times a week for @ weeks .", "sentence_id": 4}
+{"abstract_id": "24491874", "label": "methods", "text": "The HEx protocol consisted of callisthenic exercises and walking inside the pool .", "sentence_id": 5}
+{"abstract_id": "24491874", "label": "methods", "text": "The control group was asked to maintain habitual activities .", "sentence_id": 6}
+{"abstract_id": "24491874", "label": "methods", "text": "The main outcome measure was change in mean @-hour ambulatory BP ( ABPM ) .", "sentence_id": 7}
+{"abstract_id": "24491874", "label": "results", "text": "@ patients ( HEx n = @ ; control n = @ ) were randomized ; none were lost to follow-up .", "sentence_id": 8}
+{"abstract_id": "24491874", "label": "results", "text": "Office BPs decreased significantly after heated water exercise ( @/@ mmHg ) .", "sentence_id": 9}
+{"abstract_id": "24491874", "label": "results", "text": "HEx decreased @-hour systolic ( from @ to @ mmHg , p = @ ) and diastolic BPs ( from @ to @ mmHg , p = @ ) ; daytime systolic ( from @ to @ mmHg , p < @ ) and diastolic BPs ( from @ to @ mmHg , p = @ ) ; and nighttime systolic ( from @ to @ mmHg , p = @ ) and diastolic BPs ( from @ to @ mmHg , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24491874", "label": "results", "text": "The control group after @ weeks significantly increased in @-hour systolic and diastolic BPs , and daytime and nighttime diastolic BPs .", "sentence_id": 11}
+{"abstract_id": "24491874", "label": "conclusions", "text": "HEx reduced office BPs and @-hour ABPM levels in resistant hypertensive patients .", "sentence_id": 12}
+{"abstract_id": "24491874", "label": "conclusions", "text": "These effects suggest that HEx may be a potential new therapeutic approach in these patients .", "sentence_id": 13}
+{"abstract_id": "25111351", "label": "background", "text": "Botulinum neurotoxin type A trials in aesthetic indications have used differing efficacy parameters and responder definitions .", "sentence_id": 0}
+{"abstract_id": "25111351", "label": "objective", "text": "To analyze the treatment efficacy and duration of incobotulinumtoxinA for glabellar frown lines using pooled data from @ large , Phase @ , placebo-controlled trials , and end points similar to those used in previous botulinum neurotoxin type A studies .", "sentence_id": 1}
+{"abstract_id": "25111351", "label": "methods", "text": "IncobotulinumtoxinA and placebo groups comprised @ and @ subjects , respectively .", "sentence_id": 2}
+{"abstract_id": "25111351", "label": "methods", "text": "The efficacy of a single @-U treatment of incobotulinumtoxinA or placebo was evaluated by investigator-assessed and subject-assessed responder rates ( @-point improvement from baseline ) , mean score , and mean change from the baseline glabellar frown line severity score .", "sentence_id": 3}
+{"abstract_id": "25111351", "label": "results", "text": "At all follow-up visits , responder rates and mean change from the baseline score ( investigator-assessed and subject-assessed ) were significantly greater for incobotulinumtoxinA versus placebo ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25111351", "label": "results", "text": "The maximum investigator-assessed responder rate ( @ % ) was achieved at Day @ after treatment , when the mean improvement on the @-point facial wrinkle scale peaked at @ .", "sentence_id": 5}
+{"abstract_id": "25111351", "label": "results", "text": "Treatment effect declined over time but the investigator-assessed responder rate was @ % at the end of the study .", "sentence_id": 6}
+{"abstract_id": "25111351", "label": "conclusions", "text": "Superiority of incobotulinumtoxinA over placebo for treating glabellar frown lines was confirmed .", "sentence_id": 7}
+{"abstract_id": "25111351", "label": "conclusions", "text": "IncobotulinumtoxinA achieved a maximum responder rate of @ % and a long duration of treatment effect : @ % of subjects showed efficacy at @ days .", "sentence_id": 8}
+{"abstract_id": "25542740", "label": "objective", "text": "To investigate whether standardised cigarette packaging increases the time spent looking at health warnings , regardless of the format of those warnings .", "sentence_id": 0}
+{"abstract_id": "25542740", "label": "methods", "text": "A factorial ( two pack styles x three warning types ) within-subject experiment , with participants randomised to different orders of conditions , completed at a university in London , UK .", "sentence_id": 1}
+{"abstract_id": "25542740", "label": "methods", "text": "Mock-ups of cigarette packets were presented to participants with their branded portion in either standardised ( plain ) or manufacturer-designed ( branded ) format .", "sentence_id": 2}
+{"abstract_id": "25542740", "label": "methods", "text": "Health warnings were present on all packets , representing all three types currently in use in the UK : black & white text , colour text , or colour images with accompanying text .", "sentence_id": 3}
+{"abstract_id": "25542740", "label": "methods", "text": "Gaze position was recorded using a specialised eye tracker , providing the main outcome measure , which was the mean proportion of a five-second viewing period spent gazing at the warning-label region of the packet .", "sentence_id": 4}
+{"abstract_id": "25542740", "label": "results", "text": "An opportunity sample of @ ( six male , mean age = @ ) young adults met the following inclusion criteria : @ ) not currently a smoker ; @ ) < @ lifetime cigarettes smoked ; @ ) gaze position successfully tracked for > @ % viewing time .", "sentence_id": 5}
+{"abstract_id": "25542740", "label": "results", "text": "These participants spent a greater proportion of the available time gazing at the warning-label region when the branded section of the pack was standardised ( following current Australian guidelines ) rather than containing the manufacturer 's preferred design ( mean difference in proportions = @ , @ % confidence interval @ to @ , p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25542740", "label": "results", "text": "There was no evidence that this effect varied based on the type of warning label ( black & white text vs. colour text vs. colour image & text ; interaction p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25542740", "label": "conclusions", "text": "During incidental viewing of cigarette packets , young adult never-smokers are likely to spend more time looking at health warnings if manufacturers are compelled to use standardised packaging , regardless of the warning design .", "sentence_id": 8}
+{"abstract_id": "25287821", "label": "objective", "text": "To provide the @-week prevalence estimates of mental disorders in cancer populations .", "sentence_id": 0}
+{"abstract_id": "25287821", "label": "methods", "text": "We enrolled adult patients with cancer from in - and outpatient care facilities , using a proportional stratified random sample based on the nationwide cancer incidence in Germany .", "sentence_id": 1}
+{"abstract_id": "25287821", "label": "methods", "text": "Patients who scored @ or above on the Patient Health Questionnaire ( PHQ-@ ) were administered to the standardized computer-assisted Composite International Diagnostic Interview for mental disorders adapted for cancer patients ( CIDI-O ) .", "sentence_id": 2}
+{"abstract_id": "25287821", "label": "methods", "text": "A random sample of those with a PHQ-@ score that was less than @ were selected for a CIDI-O .", "sentence_id": 3}
+{"abstract_id": "25287821", "label": "results", "text": "A total of @,@ patients were identified , which led to @,@ participants ( a @ % response rate ) ; of those , @,@ patients were interviewed .", "sentence_id": 4}
+{"abstract_id": "25287821", "label": "results", "text": "The @-week total prevalence for any mental disorder was @ % ( @ % CI , @ % to @ % ) ; this included any anxiety disorder ( @ % ; @ % CI , @ % to @ % ) , any adjustment disorder ( @ % ; @ % CI , @ % to @ % ) , any mood disorder ( @ % ; @ % CI , @ % to @ % ) , any somatoform/conversion disorder ( @ % ; @ % CI , @ % to @ % ) , nicotine dependence ( @ % ; @ % CI , @ % to @ % ) , alcohol abuse/dependence ( @ % ; @ % CI , @ % to @ % ) , any mental disorder resulting from general medical condition ( @ % ; @ % CI , @ % to @ % ) , and any eating disorder ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25287821", "label": "results", "text": "The highest prevalence for any mental disorder was found in patients with breast cancer ( @ % ; @ % CI , @ % to @ % ) , followed by patients with head and neck cancer ( @ % ; @ % CI , @ % to @ % ) .", "sentence_id": 6}
+{"abstract_id": "25287821", "label": "results", "text": "The lowest prevalence was found in patients with pancreatic cancer ( @ % ; @ % CI , @ % to @ % ) and stomach/esophagus cancers ( @ % ; @ % CI , @ % to @ % ) .", "sentence_id": 7}
+{"abstract_id": "25287821", "label": "conclusions", "text": "Our findings provide evidence for the strong need for psycho-oncological interventions .", "sentence_id": 8}
+{"abstract_id": "24910976", "label": "background", "text": "Birt-Hogg-Dub syndrome ( BHD ) is a rare autosomal dominant disorder characterised by the occurrence of benign , mostly facial , skin tumours called fibrofolliculomas , multiple lung cysts , spontaneous pneumothorax and an increased renal cancer risk .", "sentence_id": 0}
+{"abstract_id": "24910976", "label": "background", "text": "Current treatments for fibrofolliculomas have high rates of recurrence and carry a risk of complications .", "sentence_id": 1}
+{"abstract_id": "24910976", "label": "background", "text": "It would be desirable to have a treatment that could prevent fibrofolliculomas from growing .", "sentence_id": 2}
+{"abstract_id": "24910976", "label": "background", "text": "Animal models of BHD have previously shown deregulation of mammalian target of rapamycin ( mTOR ) .", "sentence_id": 3}
+{"abstract_id": "24910976", "label": "background", "text": "Topical use of the mTOR inhibitor rapamycin is an effective treatment for the skin tumours ( angiofibromas ) in tuberous sclerosis complex , which is also characterised by mTOR deregulation .", "sentence_id": 4}
+{"abstract_id": "24910976", "label": "background", "text": "In this study we aimed to determine if topical rapamycin is also an effective treatment for fibrofolliculomas in BHD. .", "sentence_id": 5}
+{"abstract_id": "24910976", "label": "methods", "text": "We performed a double blinded , randomised , facial left-right controlled trial of topical rapamycin @ % versus placebo in @ BHD patients .", "sentence_id": 6}
+{"abstract_id": "24910976", "label": "methods", "text": "Trial duration was @ months .", "sentence_id": 7}
+{"abstract_id": "24910976", "label": "methods", "text": "The primary outcome was cosmetic improvement as measured by doctors and patients .", "sentence_id": 8}
+{"abstract_id": "24910976", "label": "methods", "text": "Changes in fibrofolliculoma number and size were also measured , as was occurrence of side effects .", "sentence_id": 9}
+{"abstract_id": "24910976", "label": "results", "text": "No change in cosmetic status of fibrofolliculomas was reported in the majority of cases for the rapamycin treated ( @ % by doctors , @ % by patients ) as well as the placebo treated facial sides ( both @ % ) .", "sentence_id": 10}
+{"abstract_id": "24910976", "label": "results", "text": "No significant differences between rapamycin and placebo treated facial halves were observed ( p = @ for doctors opinion , p = @ for patients opinion ) .", "sentence_id": 11}
+{"abstract_id": "24910976", "label": "results", "text": "No significant difference in fibrofolliculoma number or change in size of the fibrofolliculomas was seen after @ months .", "sentence_id": 12}
+{"abstract_id": "24910976", "label": "results", "text": "Side effects occurred more often after rapamycin treatment ( @ % of patients ) than after placebo ( @ % of patients ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24910976", "label": "results", "text": "A burning sensation , erythema , itching and dryness were most frequently reported .", "sentence_id": 14}
+{"abstract_id": "24910976", "label": "conclusions", "text": "This study provides no evidence that treatment of fibrofolliculomas with topical rapamycin in BHD results in cosmetic improvement .", "sentence_id": 15}
+{"abstract_id": "24263289", "label": "background", "text": "Accurately estimating the period of time that individuals are exposed to online intervention content is important for understanding program engagement .", "sentence_id": 0}
+{"abstract_id": "24263289", "label": "background", "text": "This can be calculated from time-stamped data reflecting navigation to and from individual webpages .", "sentence_id": 1}
+{"abstract_id": "24263289", "label": "background", "text": "Prolonged periods of inactivity are commonly handled with a time-out feature and assigned a prespecified exposure duration .", "sentence_id": 2}
+{"abstract_id": "24263289", "label": "background", "text": "Unfortunately , this practice can lead to biased results describing program exposure .", "sentence_id": 3}
+{"abstract_id": "24263289", "label": "objective", "text": "The aim of the study was to describe how multiple imputations can be used to better account for the time spent viewing webpages that result in a prolonged period of inactivity or a time-out .", "sentence_id": 4}
+{"abstract_id": "24263289", "label": "methods", "text": "To illustrate this method , we present data on time-outs collected from the Q ( @ ) randomized smoking cessation trial .", "sentence_id": 5}
+{"abstract_id": "24263289", "label": "methods", "text": "For this analysis , we evaluate the effects on intervention exposure of receiving content written in a prescriptive versus motivational tone .", "sentence_id": 6}
+{"abstract_id": "24263289", "label": "methods", "text": "Using multiple imputations , we created five complete datasets in which the time spent viewing webpages that resulted in a time-out were replaced with values estimated with imputation models .", "sentence_id": 7}
+{"abstract_id": "24263289", "label": "methods", "text": "We calculated standard errors using Rubin 's formulas to account for the variability due to the imputations .", "sentence_id": 8}
+{"abstract_id": "24263289", "label": "methods", "text": "We also illustrate how current methods of accounting for time-outs ( excluding timed-out page views or assigning an arbitrary viewing time ) can influence conclusions about participant engagement .", "sentence_id": 9}
+{"abstract_id": "24263289", "label": "results", "text": "A total of @ % ( @/@ ) of participants accessed the online intervention in the Q ( @ ) trial .", "sentence_id": 10}
+{"abstract_id": "24263289", "label": "results", "text": "Of the @ unique page views , @ ( @ % , @/@ ) resulted in a time-out .", "sentence_id": 11}
+{"abstract_id": "24263289", "label": "results", "text": "The median time spent viewing webpages that did not result in a time-out was @ minutes .", "sentence_id": 12}
+{"abstract_id": "24263289", "label": "results", "text": "Assuming participants did not spend any time viewing a webpage that resulted in a time-out , no difference between the two message tones was observed ( ratio of mean time online : @ , @ % CI @-@ @ ) .", "sentence_id": 13}
+{"abstract_id": "24263289", "label": "results", "text": "Assigning @ minutes of viewing time to all page views that resulted in a time-out concludes that participants who received content in a motivational tone spent less time viewing content ( ratio of mean time online : @ , @ % CI @-@ @ ) than those participants who received content in a prescriptive tone .", "sentence_id": 14}
+{"abstract_id": "24263289", "label": "results", "text": "Using multiple imputations to account for time-outs concludes that there is no difference in participant engagement between the two message tones ( ratio of mean time online : @ ; @ % CI @-@ @ ) .", "sentence_id": 15}
+{"abstract_id": "24263289", "label": "conclusions", "text": "The analytic technique chosen can significantly affect conclusions about online intervention engagement .", "sentence_id": 16}
+{"abstract_id": "24263289", "label": "conclusions", "text": "We propose a standardized methodology in which time spent viewing webpages that result in a time-out is treated as missing information and corrected with multiple imputations .", "sentence_id": 17}
+{"abstract_id": "25714214", "label": "objective", "text": "To evaluate the lung function and clinical outcome in severe chronic obstructive pulmonary disease in patients undergoing off-pump coronary artery bypass grafting with left internal thoracic artery graft , comparing the pleural drain insertion in the intercostal versus subxyphoid region .", "sentence_id": 0}
+{"abstract_id": "25714214", "label": "methods", "text": "A randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25714214", "label": "methods", "text": "Chronic obstructive pulmonary disease patients were randomized into two groups according pleural drain site : II group ( n = @ ) - pleural drain in intercostal space ; SI group ( n = @ ) - pleural drain in the subxyphoid region .", "sentence_id": 2}
+{"abstract_id": "25714214", "label": "methods", "text": "Spirometry values ( Forced Vital Capacity - and Forced expiratory volume in @ second ) were obtained on preoperative and @ , @ and @ postoperative days .", "sentence_id": 3}
+{"abstract_id": "25714214", "label": "methods", "text": "Chest x-ray from preoperative until postoperative day @ ( POD@ ) was performed for monitoring respiratory events , such as atelectasis and pleural effusion .", "sentence_id": 4}
+{"abstract_id": "25714214", "label": "methods", "text": "Pulmonary shunt fraction and pain score was evaluate preoperatively and on postoperative day @ .", "sentence_id": 5}
+{"abstract_id": "25714214", "label": "results", "text": "In both groups there was a significant decrease of the spirometry values ( Forced Vital Capacity and Forced expiratory volume in @ second ) until POD@ ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25714214", "label": "results", "text": "However , when compared , SI group presented less decrease in these parameters ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25714214", "label": "results", "text": "Pulmonary shunt fraction was significantly lower in SI group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25714214", "label": "results", "text": "Respiratory events , pain score , orotracheal intubation time and postoperative length of hospital stay were lower in the SI group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25714214", "label": "conclusions", "text": "Subxyphoid pleural drainage in severe Chronic obstructive pulmonary disease patients determined better preservation and recovery of pulmonary capacity and volumes with lower pulmonary shunt fraction and better clinical outcomes on early postoperative off-pump coronary artery bypass grafting .", "sentence_id": 10}
+{"abstract_id": "24342746", "label": "objective", "text": "Little is known about the effects of natural mineral water on constipation in adults .", "sentence_id": 0}
+{"abstract_id": "24342746", "label": "objective", "text": "We assessed the effect of a magnesium sulfate-rich natural mineral water ( Hpar ; Nestl Waters , Issy-les-Moulineaux , France ) on gastrointestinal transit in constipated women .", "sentence_id": 1}
+{"abstract_id": "24342746", "label": "methods", "text": "We performed a randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of Hpar in outpatients with functional constipation ( based on the Rome III criteria ) .", "sentence_id": 2}
+{"abstract_id": "24342746", "label": "methods", "text": "The study included @ female patients , age @ to @ years , identified by @ general practitioners throughout France .", "sentence_id": 3}
+{"abstract_id": "24342746", "label": "methods", "text": "After a washout period , subjects drank @ L natural low-mineral water daily ( control , n = @ ) , @ L Hpar and @ L natural low-mineral water daily ( Hpar @ group , n = @ ) , or @ L Hpar and @ L natural low-mineral water daily ( Hpar @ group , n = @ ) for @ weeks .", "sentence_id": 4}
+{"abstract_id": "24342746", "label": "methods", "text": "We collected information on the number and types of stools , abdominal pain , rescue medications , adverse events , and volume of water consumed .", "sentence_id": 5}
+{"abstract_id": "24342746", "label": "results", "text": "We observed no significant effect at week @ .", "sentence_id": 6}
+{"abstract_id": "24342746", "label": "results", "text": "At week @ , constipation was reduced in @ % of patients in the control group , in @ % in the Hpar @ group ( P = @ vs controls ) , and in @ % in the Hpar @ group ( P = @ vs controls ) .", "sentence_id": 7}
+{"abstract_id": "24342746", "label": "results", "text": "The Hpar @ group also had a decreased number of hard or lumpy stools ( Bristol scale , P = @ vs baseline ) and a substantial decrease in the use of rescue medication ( P = @ vs controls ) .", "sentence_id": 8}
+{"abstract_id": "24342746", "label": "results", "text": "Patient responses correlated with magnesium sulfate concentrations .", "sentence_id": 9}
+{"abstract_id": "24342746", "label": "results", "text": "Safety was very good ; there were no serious adverse events among patients who drank Hpar .", "sentence_id": 10}
+{"abstract_id": "24342746", "label": "conclusions", "text": "In a controlled trial , daily consumption of @ L Hpar reduced constipation and hard or lumpy stools in a greater percentage of women with functional constipation than natural low-mineral water , as early as the second week of treatment .", "sentence_id": 11}
+{"abstract_id": "25135542", "label": "objective", "text": "To evaluate the efficacy of adding nepafenac @ % ophthalmic suspension to dexamethasone @ % eyedrops in controlling macular swelling and other manifestations of inflammation after uneventful cataract surgery .", "sentence_id": 0}
+{"abstract_id": "25135542", "label": "methods", "text": "Ophthalmology Department , Mlndal Hospital , Gothenburg , and St. Erik Eye Hospital , Stockholm , Sweden .", "sentence_id": 1}
+{"abstract_id": "25135542", "label": "methods", "text": "Randomized double-masked clinical trial .", "sentence_id": 2}
+{"abstract_id": "25135542", "label": "methods", "text": "Patients at low risk for postoperative inflammation were recruited and randomized to the nepafenac group or to the control group .", "sentence_id": 3}
+{"abstract_id": "25135542", "label": "methods", "text": "Postoperative swelling of the macula was assessed with ocular coherence tomography .", "sentence_id": 4}
+{"abstract_id": "25135542", "label": "methods", "text": "Laser flare intensity , corrected distance visual acuity , ocular discomfort , and visual complaints were also recorded .", "sentence_id": 5}
+{"abstract_id": "25135542", "label": "results", "text": "The analysis of intent-to-treat population comprised @ patients in the nepafenac group and @ patients in the control group .", "sentence_id": 6}
+{"abstract_id": "25135542", "label": "results", "text": "Compared with the control regimen , add-on nepafenac resulted in statistically significant reductions in the following parameters : change in macular volume at @ weeks and @ weeks ( P < @ ) , proportion of patients with more than @ m of swelling in the central macula at @ weeks ( P < @ ) and @ weeks ( P = @ ) , mean laser flare intensity at @ day ( P = @ ) , pain during the first @ hours postoperatively ( P < @ ) , and ocular discomfort and photophobia during the first @ postoperative weeks ( P = @ and P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "25135542", "label": "conclusions", "text": "The combination of topical nepafenac and steroid treatment reduced subclinical macular swelling and inflammation as well as subjective complaints , indicating it is an efficient antiinflammatory regimen after cataract surgery .", "sentence_id": 8}
+{"abstract_id": "24625502", "label": "objective", "text": "Cutaneous telangiectases are a characteristic and psychologically distressing feature of SSc .", "sentence_id": 0}
+{"abstract_id": "24625502", "label": "objective", "text": "Our aim was to assess the efficacy of two light-based treatments : pulsed dye laser ( PDL ) and intense pulsed light ( IPL ) .", "sentence_id": 1}
+{"abstract_id": "24625502", "label": "methods", "text": "Nineteen patients with facial or upper limb telangiectases underwent three treatments with PDL and IPL ( randomly assigned to left - and right-sided lesions ) .", "sentence_id": 2}
+{"abstract_id": "24625502", "label": "methods", "text": "Outcome measures were clinical photography ( assessed by two clinicians ) , dermoscopy ( assessed by two observers ) , laser Doppler imaging ( LDI ) and observer and patient opinion , including patient self-assessment psychological questionnaires -LSB- Hospital Anxiety and Depression Scale ( HADS ) , Adapted Satisfaction with Appearance Scale ( ASWAP ) -RSB- .", "sentence_id": 3}
+{"abstract_id": "24625502", "label": "results", "text": "Comparison between @-week follow-up and baseline photography scores ( from -@ to +@ on a Likert scale , with > @ being improvement ) were a mean score for PDL of @ ( @ % CI @ , @ ) and for IPL @ ( @ , @ ) , with a mean difference between PDL and IPL of -@ ( -@ , -@ ) ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24625502", "label": "results", "text": "Dermoscopy scores also improved with both therapies : PDL @ ( @ , @ ) and IPL @ ( @ , @ ) , again greater with PDL ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24625502", "label": "results", "text": "LDI showed decreases in blood flow at @ weeks , indicating a response to both therapies .", "sentence_id": 6}
+{"abstract_id": "24625502", "label": "results", "text": "All patients reported benefit from treatment ( more preferred PDL at @ weeks ) .", "sentence_id": 7}
+{"abstract_id": "24625502", "label": "results", "text": "Psychological questionnaires also indicated improvement after therapy with mean change in ASWAP of -@ ( @ % CI -@ , -@ ) .", "sentence_id": 8}
+{"abstract_id": "24625502", "label": "results", "text": "No side effects were reported for IPL ; PDL caused transient bruising in most cases .", "sentence_id": 9}
+{"abstract_id": "24625502", "label": "conclusions", "text": "Both PDL and IPL are effective treatments for SSc-related telangiectases .", "sentence_id": 10}
+{"abstract_id": "24625502", "label": "conclusions", "text": "Outcome measures indicate that PDL has better outcomes in terms of appearance , although IPL had fewer side effects .", "sentence_id": 11}
+{"abstract_id": "25146745", "label": "objective", "text": "To explore the roles of ribavirin aerosol in the prevention and treatment of hand-foot-mouth disease ( HFMD ) .", "sentence_id": 0}
+{"abstract_id": "25146745", "label": "methods", "text": "For this prospective , multicenter , randomized , double-blind and placebo-controlled trial , a total of @ HFMD outpatients from @ class @A hospitals from July @ to June @ were divided into treatment ( ribavirin aerosol ) and control ( placebo ) groups ( n = @ each ) .", "sentence_id": 1}
+{"abstract_id": "25146745", "label": "methods", "text": "The age range was @ months to @ years .", "sentence_id": 2}
+{"abstract_id": "25146745", "label": "methods", "text": "The proportion of male and female was @ : @ .", "sentence_id": 3}
+{"abstract_id": "25146745", "label": "methods", "text": "Temperature , herpes of mouth and skin rash were observed before and after treatments .", "sentence_id": 4}
+{"abstract_id": "25146745", "label": "methods", "text": "Before treatment and @-@ days after , their specimens of throat swab were collected and the levels of EV@ and CA@ detected with reverse transcription ( RT ) - PCR .", "sentence_id": 5}
+{"abstract_id": "25146745", "label": "methods", "text": "The software SAS @ was used for statistic data analyses .", "sentence_id": 6}
+{"abstract_id": "25146745", "label": "results", "text": "Before treatment , no significant statistical difference existed in parameters between treatment and control groups ( all P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25146745", "label": "results", "text": "After treatment , the degree of herpes of mouth and papulovesicle of skin in treatment group was better than that in control group ( @ % ( @/@ ) vs @ % ( @/@ ) , ( @ ) = @ , P < @ ) ; ( @ % ( @/@ ) vs @ % ( @/@ ) , ( @ ) = @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25146745", "label": "results", "text": "The virus negative conversion rates had significant inter-group difference ( @ % ( @/@ ) vs @ % ( @/@ ) , ( @ ) = @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25146745", "label": "results", "text": "The temperature , compliance and differences were not significant ( all P > @ ) .", "sentence_id": 10}
+{"abstract_id": "25146745", "label": "results", "text": "The effective rate of comprehensive efficacy in treatment group was higher than that in control group ( @ % ( @/@ ) vs @ % ( @/@ ) , ( @ ) = @ , P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25146745", "label": "results", "text": "No obvious adverse drug reaction was observed .", "sentence_id": 12}
+{"abstract_id": "25146745", "label": "conclusions", "text": "Ribavirin aerosol has multiple advantages of lower dose , quicker onset , higher local concentration , better clinical efficacy and fewer side-effects .", "sentence_id": 13}
+{"abstract_id": "25146745", "label": "conclusions", "text": "Its therapeutic effect for local lesion is better than that for systemic lesion .", "sentence_id": 14}
+{"abstract_id": "25146745", "label": "conclusions", "text": "Thus it may shorten the duration of oropharyngeal and skin lesions and lower the number and time of viral release .", "sentence_id": 15}
+{"abstract_id": "25701561", "label": "background", "text": "Early combination antiretroviral therapy ( cART ) initiation at the time of primary HIV-@ infection could restrict the establishment of HIV reservoirs .", "sentence_id": 0}
+{"abstract_id": "25701561", "label": "background", "text": "We aimed to assess the effect of a cART regimen intensified with raltegravir and maraviroc , compared with standard triple-drug cART , on HIV-DNA load .", "sentence_id": 1}
+{"abstract_id": "25701561", "label": "methods", "text": "In this randomised , open-label , phase @ trial , we recruited patients from hospitals across France .", "sentence_id": 2}
+{"abstract_id": "25701561", "label": "methods", "text": "Inclusion criteria were primary HIV-@ infection ( an incomplete HIV-@ western blot and detectable plasma HIV-RNA ) , with either symptoms or a CD@ + cell count below @ cells per L. Patients were randomly assigned ( @:@ ) to an intensive , five-drug cART regimen ( raltegravir @ mg and maraviroc @ mg twice daily , and a fixed-dose combination of tenofovir disoproxil fumarate @ g plus emtricitabine @ g , darunavir @ g , and ritonavir @ g once daily ) or a standard triple-drug cART regimen ( tenofovir disoproxil fumarate @ g plus emtricitabine @ g , darunavir @ g , and ritonavir @ g once daily ) using a predefined randomised list generated by randomly selected variable block sizes .", "sentence_id": 3}
+{"abstract_id": "25701561", "label": "methods", "text": "The primary endpoint was the median number of HIV-DNA copies per @ ( @ ) peripheral blood mononuclear cells ( PBMC ) at month @ , analysed in the modified intention-to-treat population , defined as all patients who started their assigned treatment .", "sentence_id": 4}
+{"abstract_id": "25701561", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 5}
+{"abstract_id": "25701561", "label": "results", "text": "Between April @ , @ , and July @ , @ , @ patients were enrolled , of whom @ were randomly assigned and @ started treatment ( @ in each treatment group ) .", "sentence_id": 6}
+{"abstract_id": "25701561", "label": "results", "text": "Six ( @ % ) patients in the intensive cART group and two ( @ % ) in the standard cART group discontinued before month @ .", "sentence_id": 7}
+{"abstract_id": "25701561", "label": "results", "text": "At month @ , HIV-DNA loads were similar between groups ( @ -LSB- IQR @-@ -RSB- log per @ ( @ ) PBMC in the intensive cART group vs @ -LSB- @-@ -RSB- in the standard cART group ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25701561", "label": "results", "text": "Eight grade @-@ clinical adverse events were reported in seven patients in the intensive cART group and seven grade @-@ clinical adverse events were reported in seven patients in the standard cART group .", "sentence_id": 9}
+{"abstract_id": "25701561", "label": "results", "text": "Three serious clinical adverse events occurred : two ( pancreatitis and lipodystrophy ) in the standard cART group , which were regarded as treatment related , and one event ( suicide attempt ) in the intensive cART group that was unrelated to treatment .", "sentence_id": 10}
+{"abstract_id": "25701561", "label": "conclusions", "text": "After @ months , cART intensified with raltegravir and maraviroc did not have a greater effect on HIV blood reservoirs than did standard cART .", "sentence_id": 11}
+{"abstract_id": "25701561", "label": "conclusions", "text": "These results should help to design future trials of treatments aiming to decrease the HIV reservoir in patients with primary HIV-@ infection .", "sentence_id": 12}
+{"abstract_id": "25503625", "label": "objective", "text": "To test the effects of pregabalin on the induction of neurogenic claudication .", "sentence_id": 0}
+{"abstract_id": "25503625", "label": "methods", "text": "This study was a randomized , double-blind , active placebo-controlled , @-period , crossover trial .", "sentence_id": 1}
+{"abstract_id": "25503625", "label": "methods", "text": "Twenty-nine subjects were randomized to receive pregabalin followed by active placebo ( i.e. , diphenhydramine ) or active placebo followed by pregabalin .", "sentence_id": 2}
+{"abstract_id": "25503625", "label": "methods", "text": "Each treatment period lasted @ days , including a @-step titration .", "sentence_id": 3}
+{"abstract_id": "25503625", "label": "methods", "text": "Periods were separated by a @-day washout period , including a @-day taper phase after the first period .", "sentence_id": 4}
+{"abstract_id": "25503625", "label": "methods", "text": "The primary outcome variable was the time to first moderate pain symptom ( Numeric Rating Scale score @ ) during a @-minute treadmill test ( Tfirst ) .", "sentence_id": 5}
+{"abstract_id": "25503625", "label": "methods", "text": "Secondary outcome measures included pain intensity at rest , pain intensity at the end of the treadmill test , distance walked , and validated self-report measures of pain and functional limitation including the Roland-Morris Disability Questionnaire , modified Brief Pain Inventory-Short Form , Oswestry Disability Index , and Swiss Spinal Stenosis Questionnaire .", "sentence_id": 6}
+{"abstract_id": "25503625", "label": "results", "text": "No significant difference was found between pregabalin and active placebo for the time to first moderate pain symptom ( difference in median Tfirst = -@ -LSB- @ % confidence interval -@ to @ -RSB- , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25503625", "label": "results", "text": "In addition , none of the secondary outcome measures of pain or functional limitation were significantly improved by pregabalin compared with active placebo .", "sentence_id": 8}
+{"abstract_id": "25503625", "label": "conclusions", "text": "Pregabalin was not more effective than active placebo in reducing painful symptoms or functional limitations in patients with neurogenic claudication associated with lumbar spinal stenosis .", "sentence_id": 9}
+{"abstract_id": "25503625", "label": "methods", "text": "This study provides Class I evidence that for patients with neurogenic claudication , compared with diphenhydramine , pregabalin does not increase the time to moderate pain during a treadmill test .", "sentence_id": 10}
+{"abstract_id": "25053388", "label": "objective", "text": "A phase @ study was conducted to evaluate the bioavailability and food effect of a new veliparib formulation in subjects with solid tumors .", "sentence_id": 0}
+{"abstract_id": "25053388", "label": "methods", "text": "Subjects ( planned : Stage I , N = @ ; Stage II , N = @ ) received four regimens of a single oral dose of veliparib utilizing a group-sequential design .", "sentence_id": 1}
+{"abstract_id": "25053388", "label": "methods", "text": "Subjects were administered single doses of @ mg veliparib supplied as four @ mg current formulation , four @ mg new formulation and one @ mg new formulation under fasting conditions and under non-fasting conditions .", "sentence_id": 2}
+{"abstract_id": "25053388", "label": "methods", "text": "Serial blood samples were collected for the determination of veliparib pharmacokinetics .", "sentence_id": 3}
+{"abstract_id": "25053388", "label": "methods", "text": "At the end of Stage I , the relative bioavailability between each pair of regimens was assessed by a two one-sided tests procedure from the analyses of the natural logarithms of C ( max ) and AUC .", "sentence_id": 4}
+{"abstract_id": "25053388", "label": "methods", "text": "A @ % confidence interval within the @-@ @ range between each regimen pair determined bioequivalence .", "sentence_id": 5}
+{"abstract_id": "25053388", "label": "results", "text": "Four @ mg current formulation capsules , four @ mg new formulation and one @ mg new formulation were bioequivalent with respect to C ( max ) and AUC under fasting conditions .", "sentence_id": 6}
+{"abstract_id": "25053388", "label": "results", "text": "The administration of a high-fat meal did not have a significant effect on AUC and only caused a slight decrease in veliparib C ( max ) ( @ % ) and a delay of approximately @ h in T ( max ) .", "sentence_id": 7}
+{"abstract_id": "25053388", "label": "conclusions", "text": "The @ mg new capsule was bioequivalent to currently used formulation .", "sentence_id": 8}
+{"abstract_id": "25053388", "label": "conclusions", "text": "Food had no effect on the extent of veliparib absorption and only a small ( @ % ) decrease in peak exposure of veliparib .", "sentence_id": 9}
+{"abstract_id": "25012498", "label": "background", "text": "Renin-angiotensin system inhibition ( RASI ) is frequently avoided in aortic stenosis ( AS ) patients because of fear of hypotension .", "sentence_id": 0}
+{"abstract_id": "25012498", "label": "background", "text": "We evaluated if RASI with angiotensin-converting enzyme inhibitor ( ACEI ) or angiotensin receptor blocker ( ARB ) increased mortality in patients with mild to moderate AS .", "sentence_id": 1}
+{"abstract_id": "25012498", "label": "methods", "text": "All patients ( n = @ ) from the Simvastatin and Ezetimibe in Aortic Stenosis study : asymptomatic patients with AS and preserved left ventricular ( LV ) ejection fraction were included .", "sentence_id": 2}
+{"abstract_id": "25012498", "label": "methods", "text": "Risks of sudden cardiac death ( SCD ) , cardiovascular death and all-cause mortality according to RASI treatment were analyzed by multivariable time-varying Cox models and propensity score matched analyses .", "sentence_id": 3}
+{"abstract_id": "25012498", "label": "results", "text": "@ ( @ % ) patients received RASI .", "sentence_id": 4}
+{"abstract_id": "25012498", "label": "results", "text": "During a median follow-up of @ @ years , @ patients were categorized as having severe AS , @ underwent aortic valve replacement , @ SCDs , @ cardiovascular and @ all-cause deaths occurred .", "sentence_id": 5}
+{"abstract_id": "25012498", "label": "results", "text": "RASI was not associated with SCD ( HR : @ -LSB- @ % CI : @-@ @ -RSB- , p = @ ) , cardiovascular ( HR : @ -LSB- @ % CI : @-@ @ -RSB- , p = @ ) or all-cause mortality ( HR : @ -LSB- @ % CI : @-@ @ -RSB- , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25012498", "label": "results", "text": "This was confirmed in propensity matched analysis ( all p > @ ) .", "sentence_id": 7}
+{"abstract_id": "25012498", "label": "results", "text": "In separate analyses , RASI was associated with larger reduction in systolic blood pressure ( p = @ ) and less progression of LV mass ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25012498", "label": "conclusions", "text": "RASI was not associated with SCD , cardiovascular or all-cause mortality in asymptomatic AS patients .", "sentence_id": 9}
+{"abstract_id": "25012498", "label": "conclusions", "text": "However , RASI was associated with a potentially beneficial decrease in blood pressure and reduced LV mass progression .", "sentence_id": 10}
+{"abstract_id": "25247991", "label": "background", "text": "Exercise capacity is a strong predictor of survival in patients with coronary artery disease ( CAD ) .", "sentence_id": 0}
+{"abstract_id": "25247991", "label": "background", "text": "Exercise capacity improves after cardiac rehabilitation exercise training , but previous studies have demonstrated a decline in peak oxygen uptake after ending a formal rehabilitation program .", "sentence_id": 1}
+{"abstract_id": "25247991", "label": "background", "text": "There is a lack of knowledge on how long-term exercise adherence can be achieved in CAD patients .", "sentence_id": 2}
+{"abstract_id": "25247991", "label": "background", "text": "We therefore assessed if a @-month maintenance program following cardiac rehabilitation would lead to increased adherence to exercise and increased exercise capacity compared to usual care .", "sentence_id": 3}
+{"abstract_id": "25247991", "label": "methods", "text": "Two-centre , open , parallel randomized controlled trial with @ months follow-up comparing usual care to a maintenance program .", "sentence_id": 4}
+{"abstract_id": "25247991", "label": "methods", "text": "The maintenance program consisted of one monthly supervised high intensity interval training session , a written exercise program and exercise diary , and a maximum exercise test every third month during follow-up .", "sentence_id": 5}
+{"abstract_id": "25247991", "label": "methods", "text": "Forty-nine patients ( @ women ) on optimal medical treatment were included following discharge from cardiac rehabilitation .", "sentence_id": 6}
+{"abstract_id": "25247991", "label": "methods", "text": "The primary endpoint was change in peak oxygen uptake at follow-up ; secondary endpoints were physical activity level , quality of life and blood markers of cardiovascular risk .", "sentence_id": 7}
+{"abstract_id": "25247991", "label": "results", "text": "There was no change in peak oxygen uptake from baseline to follow-up in either group ( intervention group @ ( @ ) to @ ( @ ) mLkg ( -@ ) min ( -@ ) , control group @ ( @ ) to @ ( @ ) mLkg ( -@ ) min ( -@ ) , with no between-group difference , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25247991", "label": "results", "text": "Quality of life and blood biomarkers remained essentially unchanged , and both self-reported and measured physical activity levels were similar between groups after @ months .", "sentence_id": 9}
+{"abstract_id": "25247991", "label": "conclusions", "text": "A maintenance exercise program for @ months did not improve adherence to exercise or peak oxygen uptake in CAD patients after discharge from cardiac rehabilitation compared to usual care .", "sentence_id": 10}
+{"abstract_id": "25247991", "label": "conclusions", "text": "This suggests that infrequent supervised high intensity interval training sessions are inadequate to improve peak oxygen uptake in this patient group .", "sentence_id": 11}
+{"abstract_id": "25776532", "label": "background", "text": "Early , goal-directed therapy ( EGDT ) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock .", "sentence_id": 0}
+{"abstract_id": "25776532", "label": "background", "text": "However , adoption has been limited , and uncertainty about its effectiveness remains .", "sentence_id": 1}
+{"abstract_id": "25776532", "label": "methods", "text": "We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in @ hospitals in England .", "sentence_id": 2}
+{"abstract_id": "25776532", "label": "methods", "text": "Patients were randomly assigned to receive either EGDT ( a @-hour resuscitation protocol ) or usual care .", "sentence_id": 3}
+{"abstract_id": "25776532", "label": "methods", "text": "The primary clinical outcome was all-cause mortality at @ days .", "sentence_id": 4}
+{"abstract_id": "25776532", "label": "results", "text": "We enrolled @ patients , with @ assigned to EGDT and @ to usual care .", "sentence_id": 5}
+{"abstract_id": "25776532", "label": "results", "text": "By @ days , @ of @ patients ( @ % ) in the EGDT group and @ of @ patients ( @ % ) in the usual-care group had died ( relative risk in the EGDT group , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) , for an absolute risk reduction in the EGDT group of -@ percentage points ( @ % CI , -@ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25776532", "label": "results", "text": "Increased treatment intensity in the EGDT group was indicated by increased use of intravenous fluids , vasoactive drugs , and red-cell transfusions and reflected by significantly worse organ-failure scores , more days receiving advanced cardiovascular support , and longer stays in the intensive care unit .", "sentence_id": 7}
+{"abstract_id": "25776532", "label": "results", "text": "There were no significant differences in any other secondary outcomes , including health-related quality of life , or in rates of serious adverse events .", "sentence_id": 8}
+{"abstract_id": "25776532", "label": "results", "text": "On average , EGDT increased costs , and the probability that it was cost-effective was below @ % .", "sentence_id": 9}
+{"abstract_id": "25776532", "label": "conclusions", "text": "In patients with septic shock who were identified early and received intravenous antibiotics and adequate fluid resuscitation , hemodynamic management according to a strict EGDT protocol did not lead to an improvement in outcome .", "sentence_id": 10}
+{"abstract_id": "25776532", "label": "conclusions", "text": "( Funded by the United Kingdom National Institute for Health Research Health Technology Assessment Programme ; ProMISe Current Controlled Trials number , ISRCTN@ . )", "sentence_id": 11}
+{"abstract_id": "24462498", "label": "objective", "text": "To identify characteristics of hemodialysis patients most likely to experience difficulty adhering to sodium restrictions associated with their dietary regimen .", "sentence_id": 0}
+{"abstract_id": "24462498", "label": "methods", "text": "Secondary analysis using baseline data from an ongoing randomized clinical trial examining the effects of a technology-supported behavioral intervention on dietary sodium intake in hemodialysis patients .", "sentence_id": 1}
+{"abstract_id": "24462498", "label": "methods", "text": "Thirteen dialysis centers in southwestern Pennsylvania .", "sentence_id": 2}
+{"abstract_id": "24462498", "label": "methods", "text": "We included @ participants ( @ % women ; @ % African American ) aged @ @ years undergoing maintenance , intermittent hemodialysis for end-stage renal disease .", "sentence_id": 3}
+{"abstract_id": "24462498", "label": "methods", "text": "Normalized dietary sodium intake , adjusted interdialytic weight gain , perceived problems , and self-efficacy for restricting dietary sodium .", "sentence_id": 4}
+{"abstract_id": "24462498", "label": "results", "text": "Younger participants were more likely to report problems managing their hemodialysis diet and low self-efficacy for restricting sodium intake .", "sentence_id": 5}
+{"abstract_id": "24462498", "label": "results", "text": "Consistent with these findings , younger participants had a higher median sodium intake and higher average adjusted interdialytic weight gain .", "sentence_id": 6}
+{"abstract_id": "24462498", "label": "results", "text": "Females reported more problems managing their diet .", "sentence_id": 7}
+{"abstract_id": "24462498", "label": "results", "text": "Race , time on dialysis , and perceived income adequacy did not seem to influence outcome measures .", "sentence_id": 8}
+{"abstract_id": "24462498", "label": "conclusions", "text": "Our findings suggest that patients who are younger and female encounter more difficulty adhering to the hemodialysis regimen .", "sentence_id": 9}
+{"abstract_id": "24462498", "label": "conclusions", "text": "Hence , there may be a need to individualize counseling and interventions for these individuals .", "sentence_id": 10}
+{"abstract_id": "24462498", "label": "conclusions", "text": "Further investigation is needed to understand the independent effects of age and gender on adherence to hemodialysis dietary recommendations and perceived self-efficacy .", "sentence_id": 11}
+{"abstract_id": "25590926", "label": "background", "text": "Ventricular and supraventricular premature complexes ( PC ) are frequent and usually symptomatic .", "sentence_id": 0}
+{"abstract_id": "25590926", "label": "background", "text": "According to a previous study , magnesium pidolate ( MgP ) administration to symptomatic patients can improve the PC density and symptoms .", "sentence_id": 1}
+{"abstract_id": "25590926", "label": "objective", "text": "To assess the late follow-up of that clinical intervention in patients treated with MgP or placebo .", "sentence_id": 2}
+{"abstract_id": "25590926", "label": "methods", "text": "In the first phase of the study , @ symptomatic and consecutive patients with PC were randomized ( double-blind ) to receive either MgP or placebo for @ days .", "sentence_id": 3}
+{"abstract_id": "25590926", "label": "methods", "text": "Monthly follow-up visits were conducted for @ months to assess symptoms and control electrolytes .", "sentence_id": 4}
+{"abstract_id": "25590926", "label": "methods", "text": "@-hour Holter was performed twice , regardless of symptoms , or whenever symptoms were present .", "sentence_id": 5}
+{"abstract_id": "25590926", "label": "methods", "text": "In the second phase of the study , relapsing patients , who had received MgP or placebo ( crossing-over ) in the first phase , were treated with MgP according to the same protocol .", "sentence_id": 6}
+{"abstract_id": "25590926", "label": "results", "text": "Of the @ patients initially treated with MgP , @ ( @ % ) relapsed during the @-month follow-up , and the relapse time varied .", "sentence_id": 7}
+{"abstract_id": "25590926", "label": "results", "text": "Relapsing patients treated again had a statistically significant reduction in the PC density of @ / hour ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25590926", "label": "results", "text": "The crossing-over patients reduced it by @/hour ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25590926", "label": "results", "text": "Patients who did not relapse , had a low PC frequency ( @ PC/hour ) .", "sentence_id": 10}
+{"abstract_id": "25590926", "label": "results", "text": "Retreated patients had a @ % improvement in symptom , and crossing-over patients , @ % .", "sentence_id": 11}
+{"abstract_id": "25590926", "label": "conclusions", "text": "Some patients on MgP had relapse of symptoms and PC , indicating that MgP is neither a definitive nor a curative treatment for late follow-up .", "sentence_id": 12}
+{"abstract_id": "25590926", "label": "conclusions", "text": "However , improvement in the PC frequency and symptoms was observed in the second phase of treatment , similar to the response in the first phase of treatment .", "sentence_id": 13}
+{"abstract_id": "25831599", "label": "objective", "text": "To compare the efficacy of an oscillating-rotating power toothbrush with a novel brush head incorporating angled CrissCross bristles ( Oral-B Pro @ SmartSeries and Oral-B CrossAction brush head ) versus a marketed sonic toothbrush ( Colgate ProClinical A@ with the Triple Clean brush head ) in the reduction of gingivitis and plaque over a @-week period .", "sentence_id": 0}
+{"abstract_id": "25831599", "label": "methods", "text": "This was a single center , randomized , open label , examiner-blind , @-treatment , parallel group study .", "sentence_id": 1}
+{"abstract_id": "25831599", "label": "methods", "text": "Study participants who met the entrance criteria were enrolled in the study and randomly assigned to one of the two toothbrush groups .", "sentence_id": 2}
+{"abstract_id": "25831599", "label": "methods", "text": "Study participants brushed with their assigned toothbrush and a marketed fluoride dentifrice for @ minutes twice daily at home for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25831599", "label": "methods", "text": "Gingivitis and plaque were evaluated at baseline and Week @ .", "sentence_id": 4}
+{"abstract_id": "25831599", "label": "methods", "text": "Gingivitis was assessed using the Modified Gingival Index ( MGI ) and Gingival Bleeding Index ( GBI ) and plaque was assessed using the Rustogi Modified Navy Plaque Index ( RMNPI ) .", "sentence_id": 5}
+{"abstract_id": "25831599", "label": "methods", "text": "Data was analyzed using the ANCOVA with baseline as the covariate .", "sentence_id": 6}
+{"abstract_id": "25831599", "label": "results", "text": "In total , @ study participants were randomized to treatment resulting in @ study participants per group completing the study .", "sentence_id": 7}
+{"abstract_id": "25831599", "label": "results", "text": "Both brushes produced statistically significant ( P < @ ) reductions in gingivitis and plaque measures relative to baseline .", "sentence_id": 8}
+{"abstract_id": "25831599", "label": "results", "text": "The oscillating-rotating , brush with the novel brush head demonstrated statistically significantly ( P < @ ) greater reductions in all gingivitis measures , as well as whole mouth and interproximal plaque measures , compared to the sonic toothbrush .", "sentence_id": 9}
+{"abstract_id": "25831599", "label": "results", "text": "The benefit for the oscillating - rotating brush over the sonic brush was @ % for gingivitis , @ % for gingival bleeding , @ % for number of bleeding sites , @ % for whole mouth plaque , and @ % for interproximal plaque .", "sentence_id": 10}
+{"abstract_id": "25831599", "label": "results", "text": "There were no adverse events reported or observed for either brush .", "sentence_id": 11}
+{"abstract_id": "25084784", "label": "background", "text": "Value of information analysis has been proposed as an alternative to the standard hypothesis testing approach , which is based on type I and type II errors , in determining sample sizes for randomized clinical trials .", "sentence_id": 0}
+{"abstract_id": "25084784", "label": "background", "text": "However , in addition to sample size calculation , value of information analysis can optimize other aspects of research design such as possible comparator arms and alternative follow-up times , by considering trial designs that maximize the expected net benefit of research , which is the difference between the expected cost of the trial and the expected value of additional information .", "sentence_id": 1}
+{"abstract_id": "25084784", "label": "objective", "text": "To apply value of information methods to the results of a pilot study on catheter securement devices to determine the optimal design of a future larger clinical trial .", "sentence_id": 2}
+{"abstract_id": "25084784", "label": "methods", "text": "An economic evaluation was performed using data from a multi-arm randomized controlled pilot study comparing the efficacy of four types of catheter securement devices : standard polyurethane , tissue adhesive , bordered polyurethane and sutureless securement device .", "sentence_id": 3}
+{"abstract_id": "25084784", "label": "methods", "text": "Probabilistic Monte Carlo simulation was used to characterize uncertainty surrounding the study results and to calculate the expected value of additional information .", "sentence_id": 4}
+{"abstract_id": "25084784", "label": "methods", "text": "To guide the optimal future trial design , the expected costs and benefits of the alternative trial designs were estimated and compared .", "sentence_id": 5}
+{"abstract_id": "25084784", "label": "results", "text": "Analysis of the value of further information indicated that a randomized controlled trial on catheter securement devices is potentially worthwhile .", "sentence_id": 6}
+{"abstract_id": "25084784", "label": "results", "text": "Among the possible designs for the future trial , a four-arm study with @ patients/arm would provide the highest expected net benefit corresponding to @ % return-on-investment .", "sentence_id": 7}
+{"abstract_id": "25084784", "label": "results", "text": "The initially considered design of @ patients/arm , based on hypothesis testing calculations , would provide lower net benefit with return-on-investment of @ % .", "sentence_id": 8}
+{"abstract_id": "25084784", "label": "conclusions", "text": "Cost-effectiveness and value of information analyses were based on the data from a single pilot trial which might affect the accuracy of our uncertainty estimation .", "sentence_id": 9}
+{"abstract_id": "25084784", "label": "conclusions", "text": "Another limitation was that different follow-up durations for the larger trial were not evaluated .", "sentence_id": 10}
+{"abstract_id": "25084784", "label": "conclusions", "text": "The value of information approach allows efficient trial design by maximizing the expected net benefit of additional research .", "sentence_id": 11}
+{"abstract_id": "25084784", "label": "conclusions", "text": "This approach should be considered early in the design of randomized clinical trials .", "sentence_id": 12}
+{"abstract_id": "24251386", "label": "objective", "text": "To conduct a cost-effectiveness analysis comparing two different tooth replacement strategies for partially dentate older patients , namely partial removable dental prostheses ( RDP ) and functionally orientated treatment based on the shortened dental arch concept ( SDA ) .", "sentence_id": 0}
+{"abstract_id": "24251386", "label": "methods", "text": "Ninety-two partially dentate older patients completed a randomized controlled clinical trial .", "sentence_id": 1}
+{"abstract_id": "24251386", "label": "methods", "text": "Patients were randomly allocated to two treatment groups : the RDP group and the SDA group .", "sentence_id": 2}
+{"abstract_id": "24251386", "label": "methods", "text": "Treatment effect was measured using impact on oral health-related quality of life ( OHrQOL ) , and the costs involved in providing and maintaining care were recorded for all patients .", "sentence_id": 3}
+{"abstract_id": "24251386", "label": "methods", "text": "Patients were followed for @ months after treatment intervention .", "sentence_id": 4}
+{"abstract_id": "24251386", "label": "methods", "text": "All treatment was provided by a single operator .", "sentence_id": 5}
+{"abstract_id": "24251386", "label": "results", "text": "The total cost of achieving the minimally important clinical difference ( MID ) in OHrQOL for an average patient in the RDP group was @ .", "sentence_id": 6}
+{"abstract_id": "24251386", "label": "results", "text": "For the SDA group , the cost of achieving the MID for an average patient was @ .", "sentence_id": 7}
+{"abstract_id": "24251386", "label": "results", "text": "The cost-effectiveness ratio was therefore @:@ in favour of SDA treatment .", "sentence_id": 8}
+{"abstract_id": "24251386", "label": "conclusions", "text": "With an increasingly ageing population , many patients will continue to benefit from removable prostheses to replace their missing natural teeth .", "sentence_id": 9}
+{"abstract_id": "24251386", "label": "conclusions", "text": "From a purely economic standpoint , the results from this analysis suggest that the treatment of partially dentate older adults should be focused on functionally orientated treatment because it is simply more cost-effective .", "sentence_id": 10}
+{"abstract_id": "24615684", "label": "background", "text": "Previous reports suggest that adherence to patching is a major issue in amblyopia treatment .", "sentence_id": 0}
+{"abstract_id": "24615684", "label": "background", "text": "We tested with an unmasked randomised controlled clinical trial whether an intense educational/motivational intervention improves adherence when a high-dose regime is prescribed .", "sentence_id": 1}
+{"abstract_id": "24615684", "label": "methods", "text": "@ children with newly diagnosed amblyopia were randomly allocated into two treatment arms with and without educational/motivational intervention material .", "sentence_id": 2}
+{"abstract_id": "24615684", "label": "methods", "text": "Both were prescribed patching @ h/day , @ days/week for a fixed period of @ weeks .", "sentence_id": 3}
+{"abstract_id": "24615684", "label": "methods", "text": "The intervention arm received an educational/motivational intervention before patching which included information booklets , video , a cartoon story book , sticker charts and a dedicated session with a researcher .", "sentence_id": 4}
+{"abstract_id": "24615684", "label": "methods", "text": "The control arm received the usual clinical information .", "sentence_id": 5}
+{"abstract_id": "24615684", "label": "methods", "text": "The primary outcome measure was adherence measured using electronic occlusion dose monitors where a success/failure binary outcome was used to account for participants who dropped out of the study defined as patching > @ h/day .", "sentence_id": 6}
+{"abstract_id": "24615684", "label": "methods", "text": "Visual outcome , expressed as percentage visual deficit , was measured as secondary outcome .", "sentence_id": 7}
+{"abstract_id": "24615684", "label": "results", "text": "The intervention increased adherence success rate from @ % in the control group to @ % in the intervention group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24615684", "label": "results", "text": "However , visual outcome was not significantly better in the intervention group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24615684", "label": "conclusions", "text": "Our study shows that an intense educational/motivational intervention can improve adherence to patching to high prescribed doses although no significant improvement in visual outcome was observed .", "sentence_id": 10}
+{"abstract_id": "24615684", "label": "conclusions", "text": "TRIALS REGISTRATION NUMBER : ISRCTN@ ( International Standard Randomised Controlled Trial Number Register ) .", "sentence_id": 11}
+{"abstract_id": "24934646", "label": "background", "text": "Currently , there is an increased prevalence of diabetes mellitus among the elderly .", "sentence_id": 0}
+{"abstract_id": "24934646", "label": "background", "text": "To minimize adverse effects on glycemic control , prevention and management of general and oral complications in diabetic patients is essential .", "sentence_id": 1}
+{"abstract_id": "24934646", "label": "background", "text": "The purpose of the present study is to assess the effectiveness of a Lifestyle Change plus Dental Care ( LCDC ) program to improve glycemic and periodontal status in the elderly with type @ diabetes .", "sentence_id": 2}
+{"abstract_id": "24934646", "label": "methods", "text": "A quasi-experimental study was conducted in Health Centers @ ( intervention ) and @ ( control ) from October @ to January @ diabetic patients per health center were included .", "sentence_id": 3}
+{"abstract_id": "24934646", "label": "methods", "text": "At baseline , the intervention group attended a @ minute lifestyle and oral health education program , individual lifestyle counseling using motivational interviewing ( MI ) , application of self regulation manual , and individual oral hygiene instruction .", "sentence_id": 4}
+{"abstract_id": "24934646", "label": "methods", "text": "The intervention group received booster education every visit by viewing a @ minute educational video .", "sentence_id": 5}
+{"abstract_id": "24934646", "label": "methods", "text": "The control group received a routine program .", "sentence_id": 6}
+{"abstract_id": "24934646", "label": "methods", "text": "Participants were assessed at baseline and @ month follow up for glycosylated hemoglobin ( HbA@c ) , fasting plasma glucose ( FPG ) , body mass index ( BMI ) , periodontal status , knowledge , attitude and practice of oral health and diabetes mellitus .", "sentence_id": 7}
+{"abstract_id": "24934646", "label": "methods", "text": "Data were analyzed by using descriptive statistic , Chi-square test , Fisher 's exact test , t-test , and multiple linear regression .", "sentence_id": 8}
+{"abstract_id": "24934646", "label": "results", "text": "After the @ month follow up , a multiple linear regression analysis showed that the intervention group was significantly negatively correlated in both glycemic and periodontal status .", "sentence_id": 9}
+{"abstract_id": "24934646", "label": "results", "text": "Participants in the intervention group had significantly lower glycosylated hemoglobin ( HbA@c ) , fasting plasma glucose ( FPG ) , plaque index score , gingival index score , pocket depth , clinical attachment level ( CAL ) , and percentage of bleeding on probing ( BOP ) when compared to the control group .", "sentence_id": 10}
+{"abstract_id": "24934646", "label": "conclusions", "text": "The combination of lifestyle change and dental care in one program improved both glycemic and periodontal status in the elderly with type @ diabetes .", "sentence_id": 11}
+{"abstract_id": "24596005", "label": "objective", "text": "The aim of this study is to evaluate the effects of hormone replacement therapy using dienogest and medroxyprogesterone acetate on psychological symptoms in perimenopausal and postmenopausal women .", "sentence_id": 0}
+{"abstract_id": "24596005", "label": "methods", "text": "A total of @ patients who sought treatment at the menopause units of the authors ' gynecology and obstetrics clinics between of November @ and October @ complaining of vasomotor symptoms were included in the study prospectively .", "sentence_id": 1}
+{"abstract_id": "24596005", "label": "methods", "text": "The cases were divided into two groups : Group I ( @ patients ) was given @ mg estradiol valerate and @ mg dienogest , and Group II ( @ patients ) was given @ mg estradiol valerate and @ mg medroxyprogesterone acetate .", "sentence_id": 2}
+{"abstract_id": "24596005", "label": "methods", "text": "The groups ' results in months @ and @ were compared through the evaluation of vasomotor and psychological symptom levels .", "sentence_id": 3}
+{"abstract_id": "24596005", "label": "results", "text": "No significant difference was found between the groups when the initial levels of vasomotor and psychological symptom subtypes were compared ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24596005", "label": "results", "text": "It was observed that all the psychological symptoms decreased in the @th month in the group using dienogest in comparison with the initial situation , and that psychological symptoms increased in the group using medroxyprogesterone acetate in the evaluation performed in the @th month compared with the initial levels .", "sentence_id": 5}
+{"abstract_id": "24596005", "label": "results", "text": "It was also found out that there was a statistically significant difference between the two groups when compared in terms of these symptoms ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24596005", "label": "conclusions", "text": "While the use of dienogest normalizes the general psychological situation and sleep , it was observed that the use of medroxyprogesterone acetate ( MPA ) worsens the general psychological situation .", "sentence_id": 7}
+{"abstract_id": "25329583", "label": "background", "text": "Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood-brain barrier disruption , but these associations have not been assessed prospectively .", "sentence_id": 0}
+{"abstract_id": "25329583", "label": "background", "text": "Here , we aimed to determine the relationship between changes in depressive symptom severity and in blood levels of S-@ calcium-binding protein B ( S-@B ) , high-sensitivity C-reactive protein , and interleukin-@ following an inflammatory challenge .", "sentence_id": 1}
+{"abstract_id": "25329583", "label": "methods", "text": "Fifty unselected participants were recruited from a randomized , controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline .", "sentence_id": 2}
+{"abstract_id": "25329583", "label": "methods", "text": "Depressive symptom severity was measured at baseline , discharge , and six-month follow-up using the Beck Depression Inventory II ( BDI-II ) .", "sentence_id": 3}
+{"abstract_id": "25329583", "label": "methods", "text": "The primary outcome of the present biomarker study was acute change in depressive symptom severity , defined as the intra-subject difference between baseline and discharge BDI-II scores .", "sentence_id": 4}
+{"abstract_id": "25329583", "label": "methods", "text": "Blood biomarker levels were determined at baseline and @ days postoperative .", "sentence_id": 5}
+{"abstract_id": "25329583", "label": "results", "text": "Changes in S-@B levels correlated positively with acute changes in depressive symptom severity ( Spearman , @ ; P = @ ) and accounted for about one-fourth of their observed variance ( R@ , @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25329583", "label": "results", "text": "This association remained statistically significant after adjusting for baseline S-@B levels , age , weight , body-mass index , or - blocker use , but not baseline BDI-II scores ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25329583", "label": "results", "text": "There was no statistically significant association between the primary outcome and baseline S-@B levels , baseline high-sensitivity C-reactive protein or interleukin-@ levels , or changes in high-sensitivity C-reactive protein or interleukin-@ levels .", "sentence_id": 8}
+{"abstract_id": "25329583", "label": "results", "text": "Among most participants , levels of all three biomarkers were normal at baseline and markedly elevated at @ days postoperative .", "sentence_id": 9}
+{"abstract_id": "25329583", "label": "conclusions", "text": "Acute changes in depressive symptom severity were specifically associated with incremental changes in S-@B blood levels , largely independent of covariates associated with either .", "sentence_id": 10}
+{"abstract_id": "25329583", "label": "conclusions", "text": "These findings support the hypothesis that glial activation and injury and blood-brain barrier disruption can be mechanistically linked to acute exacerbation of depressive symptoms in some individuals .", "sentence_id": 11}
+{"abstract_id": "25126027", "label": "background", "text": "We hypothesized that untreated severe obstructive sleep apnea ( OSA ) is associated with elevated ambulatory blood pressure ( BP ) in subjects with high cardiovascular disease ( CVD ) risk despite medical management .", "sentence_id": 0}
+{"abstract_id": "25126027", "label": "methods", "text": "Data from the baseline examination of the Heart Biomarker Evaluation in Apnea Treatment ( HeartBEAT ) study , a @-site randomized controlled trial were analyzed .", "sentence_id": 1}
+{"abstract_id": "25126027", "label": "methods", "text": "Individuals with moderate-severe OSA ( apnea hypopnea index , AHI = @-@ ) and cardiovascular risk were recruited from cardiology practices .", "sentence_id": 2}
+{"abstract_id": "25126027", "label": "methods", "text": "Those with hypertension were included .", "sentence_id": 3}
+{"abstract_id": "25126027", "label": "methods", "text": "Intensive antihypertensive regimen ( IAR ) was defined as @ antihypertensives including a diuretic .", "sentence_id": 4}
+{"abstract_id": "25126027", "label": "methods", "text": "Definitions were : controlled BP ( BP < @/@ ) , uncontrolled elevated BP ( BP @/@ not on IAR ) and resistant elevated BP ( BP @/@ mm Hg despite IAR ) .", "sentence_id": 5}
+{"abstract_id": "25126027", "label": "methods", "text": "Associations of untreated severe OSA ( AHI @ ) and uncontrolled and resistant elevated BP were evaluated using logistic regression analyses adjusted for age , sex , race , body mass index , smoking status , diabetes , and CVD .", "sentence_id": 6}
+{"abstract_id": "25126027", "label": "results", "text": "Among the @ participants ( mean age @ @ years , @ % with severe OSA ) , @ % had controlled BP , @ % had uncontrolled elevated BP , and @ % had resistant elevated BP .", "sentence_id": 7}
+{"abstract_id": "25126027", "label": "results", "text": "Among participants prescribed IAR , resistant elevated BP was more prevalent in those with severe compared to moderate OSA ( @ % vs. @ % , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25126027", "label": "results", "text": "Participants with severe OSA had a @-fold higher adjusted odds of resistant elevated BP ( OR @ , @ % CI : @-@ @ ) , a finding not reproduced in the absence of IAR use .", "sentence_id": 9}
+{"abstract_id": "25126027", "label": "conclusions", "text": "Among patients with increased cardiovascular risk and moderate to severe OSA , untreated severe compared to moderate OSA was associated with elevated BP despite IAR suggesting untreated severe OSA contributes to poor BP control despite aggressive medication use .", "sentence_id": 10}
+{"abstract_id": "25126027", "label": "conclusions", "text": "A commentary on this article appears in this issue on page @ .", "sentence_id": 11}
+{"abstract_id": "24632316", "label": "background", "text": "The aim of this study is to explore the efficacy and safety of the combination of autologous transplantation of granulocyte colony-stimulating factor ( G-CSF ) - mobilized peripheral blood mononuclear cells ( PBMNCs ) and Panax notoginseng saponins ( PNS ) in the treatment of unreconstructable critical limb ischemia ( CLI ) .", "sentence_id": 0}
+{"abstract_id": "24632316", "label": "methods", "text": "We performed an open-label , parallel-group , single-center , randomized clinical trial in this study .", "sentence_id": 1}
+{"abstract_id": "24632316", "label": "methods", "text": "A total of @ patients were enrolled and randomly divided into @ groups ( the PBMNC + PNS group and the PBMNC group ) in a @:@ ratio .", "sentence_id": 2}
+{"abstract_id": "24632316", "label": "methods", "text": "Evaluation variables , including changes in the ankle-brachial index ( ABI ) of ischemic limbs , ulcer area , severity of rest pain , transcutaneous oxygen pressure ( T ( C ) PO@ ) , and @-min walk distance from baseline to week @ and @ , as well as angiographic scores for new collateral vessel formation at week @ , were used to compare the benefits of these @ treatment approaches .", "sentence_id": 3}
+{"abstract_id": "24632316", "label": "results", "text": "After @ weeks of treatment , improvement in ABI , T ( C ) PO@ , and @-min walk distance was significantly better in the PBMNC + PNS group .", "sentence_id": 4}
+{"abstract_id": "24632316", "label": "results", "text": "In addition , the combination of PBMNC transplantation and PNS administration yielded a greater reduction in ulcer area and severity of rest pain than did PBMNC transplantation alone .", "sentence_id": 5}
+{"abstract_id": "24632316", "label": "results", "text": "The proportion of patients experiencing any adverse event was similar between both treatment groups .", "sentence_id": 6}
+{"abstract_id": "24632316", "label": "results", "text": "Adverse events caused by PBMNC transplantation or PNS were generally mild and no serious adverse events occurred throughout the entire period of study .", "sentence_id": 7}
+{"abstract_id": "24632316", "label": "conclusions", "text": "A combination of PNS and PBMNC transplantation appears to be a safe and effective treatment for patients with unreconstructable CLI .", "sentence_id": 8}
+{"abstract_id": "24632316", "label": "conclusions", "text": "This combination may have great potential advantages in comparison with PBMNC transplantation alone and might constitute a novel therapeutic option for unreconstructable CLI .", "sentence_id": 9}
+{"abstract_id": "24977755", "label": "background", "text": "Bone marrow ( BM ) dysfunction is common in severely injured trauma patients , resulting from elevated catecholamines and plasma granulocyte colony-stimulating factor ( G-CSF ) as well as prolonged mobilization of hematopoietic progenitor cells ( HPCs ) .", "sentence_id": 0}
+{"abstract_id": "24977755", "label": "background", "text": "We have previously shown that propranolol ( - blocker -LSB- BB -RSB- ) reduces HPC mobilization in a rodent model of injury and hemorrhagic shock .", "sentence_id": 1}
+{"abstract_id": "24977755", "label": "background", "text": "We hypothesize that BB would prevent BM dysfunction in humans following severe injury .", "sentence_id": 2}
+{"abstract_id": "24977755", "label": "methods", "text": "Forty-five severely injured trauma patients were studied in a prospective , randomized pilot trial .", "sentence_id": 3}
+{"abstract_id": "24977755", "label": "methods", "text": "Twenty-five patients received BB , and @ served as untreated controls .", "sentence_id": 4}
+{"abstract_id": "24977755", "label": "methods", "text": "The dose of propranolol was adjusted to decrease the heart rate by @ % to @ % from baseline .", "sentence_id": 5}
+{"abstract_id": "24977755", "label": "methods", "text": "Blood was analyzed for the presence of HPC ( blast-forming unit erythroid cells -LSB- BFU-E -RSB- and colony-forming unit erythroid cells ) and G-CSF .", "sentence_id": 6}
+{"abstract_id": "24977755", "label": "methods", "text": "Demographic data , Injury Severity Score ( ISS ) , hemoglobin , reticulocyte number , and outcome data were obtained .", "sentence_id": 7}
+{"abstract_id": "24977755", "label": "results", "text": "The mean age of the study population was @ years ; @ % were male , with a mean ISS of @ .", "sentence_id": 8}
+{"abstract_id": "24977755", "label": "results", "text": "There is a significant increase in BFU-E in peripheral blood immediately following traumatic injury , and this mobilization persists for @ days .", "sentence_id": 9}
+{"abstract_id": "24977755", "label": "results", "text": "The use of BB significantly decreases BFU-E and colony-forming unit erythroid cells at all time points .", "sentence_id": 10}
+{"abstract_id": "24977755", "label": "results", "text": "G-CSF is significantly elevated in both groups on admission ; the use of BB decreases G-CSF levels by @ % as compared with @ % for controls .", "sentence_id": 11}
+{"abstract_id": "24977755", "label": "results", "text": "The average hemoglobin is nearly @ g higher on the day of discharge with propranolol treatment ( BB , @ @ g/dL vs. no BB , @ @ g/dL ) .", "sentence_id": 12}
+{"abstract_id": "24977755", "label": "conclusions", "text": "Following severe trauma , early treatment with propranolol following resuscitation is safe .", "sentence_id": 13}
+{"abstract_id": "24977755", "label": "conclusions", "text": "The use of propranolol blunts early tachycardia , reduces HPC mobilization , and results in a faster return to baseline of the G-CSF peak seen after injury .", "sentence_id": 14}
+{"abstract_id": "24977755", "label": "conclusions", "text": "There is also a trend toward faster recovery and resolution of anemia .", "sentence_id": 15}
+{"abstract_id": "24977755", "label": "conclusions", "text": "Propranolol may be the first therapeutic agent to show improved BM function after severe injury .", "sentence_id": 16}
+{"abstract_id": "24977755", "label": "methods", "text": "Therapeutic study , level III .", "sentence_id": 17}
+{"abstract_id": "25213157", "label": "background", "text": "Despite evidence for the effectiveness of structured psychological therapies for bipolar disorder no psychological interventions have been specifically designed to enhance personal recovery for individuals with recent-onset bipolar disorder .", "sentence_id": 0}
+{"abstract_id": "25213157", "label": "objective", "text": "A pilot study to assess the feasibility and effectiveness of a new intervention , recovery-focused cognitive-behavioural therapy ( CBT ) , designed in collaboration with individuals with recent-onset bipolar disorder intended to improve clinical and personal recovery outcomes .", "sentence_id": 1}
+{"abstract_id": "25213157", "label": "methods", "text": "A single , blind randomised controlled trial compared treatment as usual ( TAU ) with recovery-focused CBT plus TAU ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25213157", "label": "results", "text": "Recruitment and follow-up rates within @ % of pre-planned targets to @-month follow-up were achieved .", "sentence_id": 3}
+{"abstract_id": "25213157", "label": "results", "text": "An average of @ h ( s.d. = @ ) of recovery-focused CBT were attended out of a potential maximum of @ h. Compared with TAU , recovery-focused CBT significantly improved personal recovery up to @-month follow-up ( Bipolar Recovery Questionnaire mean score @ , @ % CI @-@ @ ( s.e. = @ ) , P = @ , d = @ ) and increased time to any mood relapse during up to @ months follow-up ( @ = @ , P < @ , estimated hazard ratio ( HR ) = @ , @ % CI @-@ @ ) .", "sentence_id": 4}
+{"abstract_id": "25213157", "label": "results", "text": "Groups did not differ with respect to medication adherence .", "sentence_id": 5}
+{"abstract_id": "25213157", "label": "conclusions", "text": "Recovery-focused CBT seems promising with respect to feasibility and potential clinical effectiveness .", "sentence_id": 6}
+{"abstract_id": "25213157", "label": "conclusions", "text": "Clinical - and cost-effectiveness now need to be reliably estimated in a definitive trial .", "sentence_id": 7}
+{"abstract_id": "24289224", "label": "objective", "text": "Tofacitinib is a novel , oral Janus kinase inhibitor being investigated for psoriasis .", "sentence_id": 0}
+{"abstract_id": "24289224", "label": "objective", "text": "This study assessed the relationship between pruritus and clinical signs of psoriasis ( assessed by Physician 's Global Assessment -LSB- PGA -RSB- ) in patients with moderate-to-severe chronic plaque psoriasis receiving tofacitinib .", "sentence_id": 1}
+{"abstract_id": "24289224", "label": "methods", "text": "In this @-week ( @-week treatment period , @-week observation period ) , double-blind , placebo-controlled , phase IIb study ( NCT@ ) , @ patients were randomized to tofacitinib @ , @ or @ mg BID , or placebo .", "sentence_id": 2}
+{"abstract_id": "24289224", "label": "methods", "text": "Pruritus was patient assessed using the Itch Severity Score ( ISS ) , a @-@ ( @ = worst itching ) rating scale recorded daily from baseline to week @ and at study visits .", "sentence_id": 3}
+{"abstract_id": "24289224", "label": "methods", "text": "Mediation modeling was used to determine relationships between ISS ( average score weeks @-@ ) , PGA ( average score weeks @-@ ) and treatment groups .", "sentence_id": 4}
+{"abstract_id": "24289224", "label": "results", "text": "Mediation analysis showed that @-@ @ % ( p < @ versus placebo ) of tofacitinib 's effect on pruritus was direct , and mostly independent of improvements in erythema , induration and scaling .", "sentence_id": 5}
+{"abstract_id": "24289224", "label": "results", "text": "ISS measurements had acceptable test-retest reliability .", "sentence_id": 6}
+{"abstract_id": "24289224", "label": "results", "text": "Correlation analyses with clinical outcomes supported the validity of the ISS as a pruritus measure .", "sentence_id": 7}
+{"abstract_id": "24289224", "label": "conclusions", "text": "Tofacitinib has a direct , beneficial effect on patient-reported pruritus independent from improvements in clinician-reported psoriasis severity signs .", "sentence_id": 8}
+{"abstract_id": "24289224", "label": "conclusions", "text": "The ISS demonstrated favorable psychometric characteristics , supporting its use as a pruritus assessment tool .", "sentence_id": 9}
+{"abstract_id": "24533897", "label": "background", "text": "Despite the widespread recognition that obesity in pregnant women is associated with adverse outcomes for mother and child , there is no intervention proven to reduce the risk of these complications .", "sentence_id": 0}
+{"abstract_id": "24533897", "label": "background", "text": "The primary aim of this randomised controlled trial is to assess in obese pregnant women , whether a complex behavioural intervention , based on changing diet ( to foods with a lower glycemic index ) and physical activity , will reduce the risk of gestational diabetes ( GDM ) and delivery of a large for gestational age ( LGA ) infant .", "sentence_id": 1}
+{"abstract_id": "24533897", "label": "background", "text": "A secondary aim is to determine whether the intervention lowers the long term risk of obesity in the offspring .", "sentence_id": 2}
+{"abstract_id": "24533897", "label": "methods", "text": "Multicentre randomised controlled trial comparing a behavioural intervention designed to improve glycemic control with standard antenatal care in obese pregnant women.Inclusion criteria ; women with a BMI @ kg/m@ and a singleton pregnancy between @ +@ weeks and @ +@ weeks ' gestation .", "sentence_id": 3}
+{"abstract_id": "24533897", "label": "methods", "text": "Exclusion criteria ; pre-defined , pre-existing diseases and multiple pregnancy .", "sentence_id": 4}
+{"abstract_id": "24533897", "label": "methods", "text": "Randomisation is on-line by a computer generated programme and is minimised by BMI category , maternal age , ethnicity , parity and centre .", "sentence_id": 5}
+{"abstract_id": "24533897", "label": "methods", "text": "Intervention ; this is delivered by a health trainer over @ sessions .", "sentence_id": 6}
+{"abstract_id": "24533897", "label": "methods", "text": "Based on control theory , with elements of social cognitive theory , the intervention is designed to improve maternal glycemic control .", "sentence_id": 7}
+{"abstract_id": "24533897", "label": "methods", "text": "Women randomised to the control arm receive standard antenatal care until delivery according to local guidelines .", "sentence_id": 8}
+{"abstract_id": "24533897", "label": "methods", "text": "All women have a @ g oral glucose tolerance test at @ +@ - @ +@ weeks ' gestation.Primary outcome ; Maternal : diagnosis of GDM , according to the International Association of Diabetes in Pregnancy Study Group ( IADPSG ) criteria .", "sentence_id": 9}
+{"abstract_id": "24533897", "label": "methods", "text": "Neonatal ; infant LGA defined as > @th customised birth weight centile.Sample size ; @ women to provide @ % power to detect a @ % reduction in the incidence of GDM and a @ % reduction in infants large for gestational age .", "sentence_id": 10}
+{"abstract_id": "24533897", "label": "conclusions", "text": "All aspects of this protocol have been evaluated in a pilot randomised controlled trial , with subsequent optimisation of the intervention .", "sentence_id": 11}
+{"abstract_id": "24533897", "label": "conclusions", "text": "The findings of this trial will inform whether lifestyle mediated improvement of glycemic control in obese pregnant women can minimise the risk of pregnancy complications .", "sentence_id": 12}
+{"abstract_id": "25269512", "label": "objective", "text": "Animal-assisted therapy ( AAT ) , most frequently used with dogs , is being used increasingly as an adjunctive alternative treatment for psychiatric patients .", "sentence_id": 0}
+{"abstract_id": "25269512", "label": "objective", "text": "AAT with larger animals , such as horses , may have unique benefits .", "sentence_id": 1}
+{"abstract_id": "25269512", "label": "objective", "text": "In this randomized controlled study , equine and canine forms of AAT were compared with standard treatments for hospitalized psychiatric patients to determine AAT effects on violent behavior and related measures .", "sentence_id": 2}
+{"abstract_id": "25269512", "label": "methods", "text": "The study included @ patients with recent in-hospital violent behavior or highly regressed behavior .", "sentence_id": 3}
+{"abstract_id": "25269512", "label": "methods", "text": "Hospitalization at the @-bed state psychiatric hospital was two months or longer ( mean @ years ) .", "sentence_id": 4}
+{"abstract_id": "25269512", "label": "methods", "text": "Participants were randomly selected to receive ten weekly group therapy sessions of standardized equine-assisted psychotherapy ( EAP ) , canine-assisted psychotherapy ( CAP ) , enhanced social skills psychotherapy , or regular hospital care .", "sentence_id": 5}
+{"abstract_id": "25269512", "label": "methods", "text": "Participants ' mean age was @ , @ % were female , @ % had diagnoses of schizophrenia or schizoaffective disorder , and @ % had been committed involuntarily for civil or forensic reasons .", "sentence_id": 6}
+{"abstract_id": "25269512", "label": "methods", "text": "Violence-related incident reports filed by staff in the three months after study intake were compared with reports two months preintake .", "sentence_id": 7}
+{"abstract_id": "25269512", "label": "results", "text": "Interventions were well tolerated .", "sentence_id": 8}
+{"abstract_id": "25269512", "label": "results", "text": "Analyses revealed an intervention group effect ( F = @ , df = @ and @ , p = @ ) ; post hoc tests showed specific benefits of EAP ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25269512", "label": "results", "text": "Similar AAT effects were found for the incidence of @:@ clinical observation ( F = @ , df = @ and @ , p = @ ) ; post hoc tests suggested benefits of CAP ( p = @ ) as well as EAP ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25269512", "label": "results", "text": "Covariance analyses indicated that staff can predict which patients are likely to benefit from EAP ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25269512", "label": "conclusions", "text": "AAT , and perhaps EAP uniquely , may be an effective therapeutic modality for long-term psychiatric patients at risk of violence .", "sentence_id": 12}
+{"abstract_id": "25635977", "label": "objective", "text": "Knowledge about the inhibition of centrally located angiotensin-I ( AT-I ) receptors by highly lipophilic AT-I receptor blockers and its ' effect are limited with experimental studies .", "sentence_id": 0}
+{"abstract_id": "25635977", "label": "objective", "text": "Thus , we aimed to investigate the effect of Telmisartan on Inter-dialytic weight gain ( IDWG ) % and echocardiographic measurements in anuric hemodialysis ( HD ) patients .", "sentence_id": 1}
+{"abstract_id": "25635977", "label": "methods", "text": "A total of forty-one anuric HD patients with @ months maintenance on HD were included in this prospective , randomized and self-controlled study .", "sentence_id": 2}
+{"abstract_id": "25635977", "label": "methods", "text": "Four weeks prior the study , angiotensin converting enzyme blockers and AT-I receptor blocker drugs were stopped .", "sentence_id": 3}
+{"abstract_id": "25635977", "label": "methods", "text": "Patients were assessed three times during the study protocol .", "sentence_id": 4}
+{"abstract_id": "25635977", "label": "methods", "text": "These are baseline , three months later ( without Telmisartan period ) and three months after Telmisartan therapy .", "sentence_id": 5}
+{"abstract_id": "25635977", "label": "results", "text": "IDWG % was significantly decreased in the period of with Telmisartan compared to period without Telmisartan ( @ @ % vs @ @ % , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25635977", "label": "results", "text": "After the administration of Telmisartan left ventricule end-diastolic diameter ( LVEDD ) ( p = @ ) and inferior vena cava diameter ( IVCD ) ( @ @ mm vs @ @ mm , p = @ ) were significantly decreased compared to the period of without Telmisartan .", "sentence_id": 7}
+{"abstract_id": "25635977", "label": "results", "text": "Despite of significantly changes observed in IVCD and LVEDD measurements in a period without Telmisartan , there was no significantly difference in left ventricular mass index ( LVMI ) measurements in this period .", "sentence_id": 8}
+{"abstract_id": "25635977", "label": "results", "text": "However , LVMI was significantly regressed after the administration of Telmisartan ( @ @ g vs @ @ g , p = @ respectively ) .", "sentence_id": 9}
+{"abstract_id": "25635977", "label": "conclusions", "text": "Treatment of anuric HD patients with Telmisartan at a dose of @ mg a day reduces IDWG % , LVEDD and IVCD measurements .", "sentence_id": 10}
+{"abstract_id": "25635977", "label": "conclusions", "text": "Further studies investigating the long-term effect of these beneficial effects on clinical outcomes are necessary .", "sentence_id": 11}
+{"abstract_id": "25086653", "label": "background", "text": "There are currently no serum biomarkers capable of distinguishing elevations in serum alanine aminotransferase ( ALT ) that portend serious liver injury potential from benign elevations such as those occurring during cholestyramine treatment .", "sentence_id": 0}
+{"abstract_id": "25086653", "label": "background", "text": "The aim of the research was to test the hypothesis that newly proposed biomarkers of hepatotoxicity would not significantly rise in serum during elevations in serum ALT associated with cholestyramine treatment , which has never been associated with clinically relevant liver injury .", "sentence_id": 1}
+{"abstract_id": "25086653", "label": "methods", "text": "In a double-blind placebo-controlled trial , cholestyramine ( @g ) was administered for @ days to healthy adult volunteers .", "sentence_id": 2}
+{"abstract_id": "25086653", "label": "methods", "text": "Serum from subjects with elevations in alanine aminotransferase ( ALT ) exceeding three-fold the upper limit of normal ( ULN ) were utilized for biomarker quantification .", "sentence_id": 3}
+{"abstract_id": "25086653", "label": "results", "text": "In @ of @ subjects , cholestyramine treatment resulted in ALT elevation by > @x ULN ( mean @ fold ; range @-@ fold ) .", "sentence_id": 4}
+{"abstract_id": "25086653", "label": "results", "text": "In these @ subjects , there was a @-fold mean increase in serum levels of miR-@ relative to baseline , supporting a liver origin of the serum ALT .", "sentence_id": 5}
+{"abstract_id": "25086653", "label": "results", "text": "Significant elevations were noted in mean levels of necrosis biomarkers sorbitol dehydrogenase ( @ fold ) , cytokeratin @ ( @ fold ) and HMGB@ ( @ fold ) .", "sentence_id": 6}
+{"abstract_id": "25086653", "label": "results", "text": "Caspase-cleaved cytokeratin @ , a biomarker of apoptosis was also significantly elevated ( @ fold ) .", "sentence_id": 7}
+{"abstract_id": "25086653", "label": "results", "text": "A rise in glutamate dehydrogenase ( @ fold ) may support mitochondrial dysfunction .", "sentence_id": 8}
+{"abstract_id": "25086653", "label": "conclusions", "text": "All toxicity biomarkers measured in this study were elevated along with ALT , confirming the liver origin and reflecting both hepatocyte necrosis and apoptosis .", "sentence_id": 9}
+{"abstract_id": "25086653", "label": "conclusions", "text": "Since cholestyramine treatment has no clinical liver safety concerns , we conclude that interpretation of the biomarkers studied may not be straightforward in the context of assessing liver safety of new drugs .", "sentence_id": 10}
+{"abstract_id": "24622367", "label": "background", "text": "Type @ diabetes can often be prevented by lifestyle modification ; however , successful lifestyle intervention programmes are labour intensive .", "sentence_id": 0}
+{"abstract_id": "24622367", "label": "background", "text": "Mobile phone messaging is an inexpensive alternative way to deliver educational and motivational advice about lifestyle modification .", "sentence_id": 1}
+{"abstract_id": "24622367", "label": "background", "text": "We aimed to assess whether mobile phone messaging that encouraged lifestyle change could reduce incident type @ diabetes in Indian Asian men with impaired glucose tolerance .", "sentence_id": 2}
+{"abstract_id": "24622367", "label": "methods", "text": "We did a prospective , parallel-group , randomised controlled trial between Aug @ , @ , and Nov @ , @ , at ten sites in southeast India .", "sentence_id": 3}
+{"abstract_id": "24622367", "label": "methods", "text": "Working Indian men ( aged @-@ years ) with impaired glucose tolerance were randomly assigned ( @:@ ) with a computer-generated randomisation sequence to a mobile phone messaging intervention or standard care ( control group ) .", "sentence_id": 4}
+{"abstract_id": "24622367", "label": "methods", "text": "Participants in the intervention group received frequent mobile phone messages compared with controls who received standard lifestyle modification advice at baseline only .", "sentence_id": 5}
+{"abstract_id": "24622367", "label": "methods", "text": "Field staff and participants were , by necessity , not masked to study group assignment , but allocation was concealed from laboratory personnel as well as principal and co-investigators .", "sentence_id": 6}
+{"abstract_id": "24622367", "label": "methods", "text": "The primary outcome was incidence of type @ diabetes , analysed by intention to treat .", "sentence_id": 7}
+{"abstract_id": "24622367", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24622367", "label": "results", "text": "We assessed @ participants for eligibility .", "sentence_id": 9}
+{"abstract_id": "24622367", "label": "results", "text": "@ patients were randomly assigned to either the mobile phone messaging intervention ( n = @ ) or standard care ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "24622367", "label": "results", "text": "The cumulative incidence of type @ diabetes was lower in those who received mobile phone messages than in controls : @ ( @ % ) participants in the intervention group developed type @ diabetes compared with @ ( @ % ) in the control group ( hazard ratio @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24622367", "label": "results", "text": "The number needed to treat to prevent one case of type @ diabetes was @ ( @ % CI @-@ ) .", "sentence_id": 12}
+{"abstract_id": "24622367", "label": "results", "text": "One patient in the control group died suddenly at the end of the first year .", "sentence_id": 13}
+{"abstract_id": "24622367", "label": "results", "text": "We recorded no other serious adverse events .", "sentence_id": 14}
+{"abstract_id": "24622367", "label": "conclusions", "text": "Mobile phone messaging is an effective and acceptable method to deliver advice and support towards lifestyle modification to prevent type @ diabetes in men at high risk .", "sentence_id": 15}
+{"abstract_id": "24616335", "label": "objective", "text": "We studied the unclear question whether blood pressure ( BP ) lowering reduces cardiovascular disease ( CVD ) in elderly individuals with systolic BP < @ mm Hg .", "sentence_id": 0}
+{"abstract_id": "24616335", "label": "results", "text": "We initiated a randomized placebo-controlled stratified @ @ factorial clinical trial evaluating the effects of BP lowering in @ @ elderly individuals with systolic blood pressure ( SBP ) between @ and @ mm Hg , for @ years .", "sentence_id": 1}
+{"abstract_id": "24616335", "label": "results", "text": "Following @-week active run-in , participants were randomized to aliskiren ( @ mg ) or placebo , and to an additional antihypertensive -LSB- hydrochlorothiazide ( @ mg ) or amlodipine ( @ mg ) -RSB- , or their respective placeboes .", "sentence_id": 2}
+{"abstract_id": "24616335", "label": "results", "text": "Study was terminated by sponsor after @ subjects ( age @ @ years , @ % receiving at least one antihypertensive ) were randomized and followed for @ year .", "sentence_id": 3}
+{"abstract_id": "24616335", "label": "results", "text": "Study drugs were well tolerated with few serious adverse events during run-in and after randomization , with no significant differences between treatment groups .", "sentence_id": 4}
+{"abstract_id": "24616335", "label": "results", "text": "By design , three levels of BP reductions were achieved , adjusted mean BP reductions of @ / @ mm Hg ( P < @ ) by aliskiren , @ / @ mm Hg ( P < @ ) by hydrochlorothiazide or amlodipine , and @ / @ mm Hg ( P < @ ) by double therapy compared with placebo .", "sentence_id": 5}
+{"abstract_id": "24616335", "label": "results", "text": "Twenty-five major CVD events occurred .", "sentence_id": 6}
+{"abstract_id": "24616335", "label": "results", "text": "Non-significant trends towards fewer CVD events with greater BP reductions are evident : hazard ratios ( HR ) @ -LSB- @ % confidence interval ( CI ) : @-@ @ -RSB- for @ mm Hg SBP reduction ; HR @ ( @ % CI : @-@ @ ) for @ mm Hg ; and HR @ ( @-@ @ ) for @ mm Hg reduction for primary composite of CV death , MI , stroke , or significant heart failure .", "sentence_id": 7}
+{"abstract_id": "24616335", "label": "conclusions", "text": "Sizeable reductions in BP , with potential for substantial CVD reduction , can be safely achieved using combinations of BP drugs in the elderly with normal high and Stage @ hypertension .", "sentence_id": 8}
+{"abstract_id": "24684456", "label": "background", "text": "As a result of research suggesting increased health risk with low serum @-hydroxycholecalciferol ( @ ( OH ) D ) , health care providers are measuring it frequently .", "sentence_id": 0}
+{"abstract_id": "24684456", "label": "background", "text": "Providers and patients are faced with treatment choices when low status is identified .", "sentence_id": 1}
+{"abstract_id": "24684456", "label": "objective", "text": "To compare the safety and efficacy of three vitamin D@ dietary supplements with different delivery matrices .", "sentence_id": 2}
+{"abstract_id": "24684456", "label": "methods", "text": "A @-week , parallel group , single-masked , clinical trial was conducted in Seattle , Washington and Kailua Kona , Hawaii .", "sentence_id": 3}
+{"abstract_id": "24684456", "label": "methods", "text": "Sixty-six healthy adults with ( @ ( OH ) D ) < @ ng/mL were randomly assigned to take one of three D@ supplements , ie , a chewable tablet ( TAB ) , an oil-emulsified drop ( DROP ) , or an encapsulated powder ( CAP ) at a label-claimed dose of @,@ IU/day .", "sentence_id": 4}
+{"abstract_id": "24684456", "label": "methods", "text": "Actual D@ content was assessed by a third party and the results adjusted based on the actual D@ content administered .", "sentence_id": 5}
+{"abstract_id": "24684456", "label": "methods", "text": "Mean change in @ ( OH ) D/mcg D@ administered ; difference in the proportion of D@ insufficient participants ( ie , @ ( OH ) D @ ng/mL ) reaching sufficiency ( ie , @ ( OH ) D @ ng/mL ) ; and mean change in serum @ , @-dihydroxycholecalciferol were measured .", "sentence_id": 6}
+{"abstract_id": "24684456", "label": "results", "text": "In two of the three products tested , the measured vitamin D@ content varied considerably from the label-claimed dose .", "sentence_id": 7}
+{"abstract_id": "24684456", "label": "results", "text": "Differences in @ ( OH ) D/mcg D@ administered were significantly different between groups ( P = @ ; n = @ ) .", "sentence_id": 8}
+{"abstract_id": "24684456", "label": "results", "text": "Pairwise comparisons demonstrated DROP resulted in a greater increase than TAB ( P < @ ) but not than CAP .", "sentence_id": 9}
+{"abstract_id": "24684456", "label": "results", "text": "TAB was not different from CAP .", "sentence_id": 10}
+{"abstract_id": "24684456", "label": "results", "text": "The proportions reaching sufficiency were : @ % ( TAB and CAP ) and @ % ( DROP ) ( P = @ between groups ; n = @ ) .", "sentence_id": 11}
+{"abstract_id": "24684456", "label": "results", "text": "@ , @-Dihydroxycholecalciferol did not change significantly in any group .", "sentence_id": 12}
+{"abstract_id": "24684456", "label": "conclusions", "text": "Oil-emulsified vitamin D@ supplements resulted in a greater mean change in serum @ ( OH ) D concentration , but fewer patients reaching vitamin D sufficiency , than chewable or encapsulated supplements .", "sentence_id": 13}
+{"abstract_id": "24569031", "label": "background", "text": "In the REPAIR-AMI trial , intracoronary infusion of bone marrow-derived cells ( BMCs ) was associated with a significantly greater recovery of contractile function in patients with acute myocardial infarction ( AMI ) at @-month follow-up than placebo infusion .", "sentence_id": 0}
+{"abstract_id": "24569031", "label": "background", "text": "The current analysis investigates clinical outcome and predictors of event-free survival at @ years .", "sentence_id": 1}
+{"abstract_id": "24569031", "label": "results", "text": "In the multicentre , placebo-controlled , double-blind REPAIR-AMI trial , @ patients received intracoronary infusion of BMCs ( n = @ ) or placebo ( n = @ ) into the infarct vessel @-@ days following successful percutaneous coronary intervention .", "sentence_id": 2}
+{"abstract_id": "24569031", "label": "results", "text": "Fifteen patients died in the placebo group compared with seven patients in the BMC group ( P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24569031", "label": "results", "text": "Nine placebo-treated patients and five BMC-treated patients required rehospitalization for chronic heart failure ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24569031", "label": "results", "text": "The combined endpoint cardiac/cardiovascular/unknown death or rehospitalisation for heart failure was more frequent in the placebo compared with the BMC group ( @ vs. @ events ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24569031", "label": "results", "text": "Univariate predictors of adverse outcomes were age , the CADILLAC risk score , aldosterone antagonist and diuretic treatment , changes in left ventricular ejection fraction , left ventricular end-systolic volume , and N-terminal pro-Brain Natriuretic Peptide ( all P < @ ) at @ months in the entire cohort and in the placebo group .", "sentence_id": 6}
+{"abstract_id": "24569031", "label": "results", "text": "In contrast , in the BMC group , only the basal ( P = @ ) and the stromal cell-derived factor-@-induced ( P = @ ) migratory capacity of the administered BMC were associated with improved clinical outcome .", "sentence_id": 7}
+{"abstract_id": "24569031", "label": "conclusions", "text": "In patients of the REPAIR-AMI trial , established clinical parameters are associated with adverse outcome at @ years exclusively in the placebo group , whereas the migratory capacity of the administered BMC determines event-free survival in the BMC-treated patients .", "sentence_id": 8}
+{"abstract_id": "24569031", "label": "conclusions", "text": "These data disclose a potency-effect relationship between cell therapy and long-term outcome in patients with AMI .", "sentence_id": 9}
+{"abstract_id": "25423041", "label": "background", "text": "Xpert MTB/RIF is approved for use in tuberculosis ( TB ) and rifampicin-resistance diagnosis .", "sentence_id": 0}
+{"abstract_id": "25423041", "label": "background", "text": "However , data are limited on the impact of Xpert under routine conditions in settings with high TB burden .", "sentence_id": 1}
+{"abstract_id": "25423041", "label": "results", "text": "A pragmatic prospective cluster-randomised trial of Xpert for all individuals with presumptive ( symptomatic ) TB compared to the routine diagnostic algorithm of sputum microscopy and limited use of culture was conducted in a large TB/HIV primary care clinic .", "sentence_id": 2}
+{"abstract_id": "25423041", "label": "results", "text": "The primary outcome was the proportion of bacteriologically confirmed TB cases not initiating TB treatment by @ mo after presentation .", "sentence_id": 3}
+{"abstract_id": "25423041", "label": "results", "text": "Secondary outcomes included time to TB treatment and mortality .", "sentence_id": 4}
+{"abstract_id": "25423041", "label": "results", "text": "Unblinded randomisation occurred on a weekly basis .", "sentence_id": 5}
+{"abstract_id": "25423041", "label": "results", "text": "Xpert and smear microscopy were performed on site .", "sentence_id": 6}
+{"abstract_id": "25423041", "label": "results", "text": "Analysis was both by intention to treat ( ITT ) and per protocol .", "sentence_id": 7}
+{"abstract_id": "25423041", "label": "results", "text": "Between @ September @ and @ October @ , @,@ participants were assigned to the Xpert ( n = @ ) and routine ( n = @,@ ) diagnostic algorithms ( ITT analysis ) ; @ received Xpert and @,@ routine ( per protocol analysis ) .", "sentence_id": 8}
+{"abstract_id": "25423041", "label": "results", "text": "@ % ( @/@ ) of individuals with bacteriologically confirmed TB ( smear , culture , or Xpert ) did not initiate treatment by @ mo after presentation in the Xpert arm , compared to @ % ( @/@ ) in the routine arm ( ITT analysis , risk ratio @ , @ % CI @-@ @ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25423041", "label": "results", "text": "The yield of bacteriologically confirmed TB cases among patients with presumptive TB was @ % ( @/@ ,@ ) with routine diagnosis and @ % ( @/@ ) with Xpert diagnosis ( ITT analysis , risk ratio @ , @ % CI @-@ @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25423041", "label": "results", "text": "This difference in diagnosis rates resulted in a higher rate of treatment initiation in the Xpert arm : @ % ( @/@ ,@ ) and @ % ( @/@ ) in the routine and Xpert arms , respectively ( ITT analysis , risk ratio @ , @ % CI @-@ @ , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25423041", "label": "results", "text": "Time to treatment initiation was improved overall ( ITT analysis , hazard ratio @ , @ % CI @-@ @ , p = @ ) and among HIV-infected participants ( ITT analysis , hazard ratio @ , @ % CI @-@ @ , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25423041", "label": "results", "text": "There was no difference in @-mo mortality with Xpert versus routine diagnosis .", "sentence_id": 13}
+{"abstract_id": "25423041", "label": "results", "text": "Study limitations included incorrect intervention allocation for a high proportion of participants and that the study was conducted in a single clinic .", "sentence_id": 14}
+{"abstract_id": "25423041", "label": "conclusions", "text": "These data suggest that in this routine primary care setting , use of Xpert to diagnose TB increased the number of individuals with bacteriologically confirmed TB who were treated by @ mo and reduced time to treatment initiation , particularly among HIV-infected participants .", "sentence_id": 15}
+{"abstract_id": "25336730", "label": "background", "text": "Circumsporozoite protein ( CS ) is the antigenic target for RTS , S , the most advanced malaria vaccine to date .", "sentence_id": 0}
+{"abstract_id": "25336730", "label": "background", "text": "Heterologous prime-boost with the viral vectors simian adenovirus @ ( ChAd@ ) - modified vaccinia virus Ankara ( MVA ) is the most potent inducer of T-cells in humans , demonstrating significant efficacy when expressing the preerythrocytic antigen insert multiple epitope-thrombospondin-related adhesion protein ( ME-TRAP ) .", "sentence_id": 1}
+{"abstract_id": "25336730", "label": "background", "text": "We hypothesized that ChAd@-MVA containing CS may result in a significant clinical protective efficacy .", "sentence_id": 2}
+{"abstract_id": "25336730", "label": "methods", "text": "We conducted an open-label , @-site , partially randomized Plasmodium falciparum sporozoite controlled human malaria infection ( CHMI ) study to compare the clinical efficacy of ChAd@-MVA CS with ChAd@-MVA ME-TRAP .", "sentence_id": 3}
+{"abstract_id": "25336730", "label": "results", "text": "One of @ vaccinees ( @ % ) receiving ChAd@-MVA CS and @ of @ ( @ % ) receiving ChAd@-MVA ME-TRAP achieved sterile protection after CHMI .", "sentence_id": 4}
+{"abstract_id": "25336730", "label": "results", "text": "Three of @ vaccinees ( @ % ) receiving ChAd@-MVA CS and @ of @ ( @ % ) receiving ChAd@-MVA ME-TRAP demonstrated a delay in time to treatment , compared with unvaccinated controls .", "sentence_id": 5}
+{"abstract_id": "25336730", "label": "results", "text": "In quantitative polymerase chain reaction analyses , ChAd@-MVA CS was estimated to reduce the liver parasite burden by @ % -@ % , compared with @ % -@ % for ChAd@-MVA ME-TRAP .", "sentence_id": 6}
+{"abstract_id": "25336730", "label": "conclusions", "text": "ChAd@-MVA CS does reduce the liver parasite burden , but ChAd@-MVA ME-TRAP remains the most promising antigenic insert for a vectored liver-stage vaccine .", "sentence_id": 7}
+{"abstract_id": "25336730", "label": "conclusions", "text": "Detailed analyses of parasite kinetics may allow detection of smaller but biologically important differences in vaccine efficacy that can influence future vaccine development .", "sentence_id": 8}
+{"abstract_id": "24333157", "label": "objective", "text": "The purpose of the study was to compare behavioral outcomes ( physical activity , sedentary behavior , smoking cessation , diet ) between the intervention and usual care conditions from the TEAMcare trial .", "sentence_id": 0}
+{"abstract_id": "24333157", "label": "methods", "text": "TEAMcare was a randomized trial among @ adults with depression and poorly controlled diabetes and/or coronary heart disease that promoted health behavior change and pharmacotherapy to improve health .", "sentence_id": 1}
+{"abstract_id": "24333157", "label": "methods", "text": "Behavioral outcomes were measured with the International Physical Activity Questionnaire ( physical activity , sitting time ) and the Summary of Diabetes Self-Care Activities Measure ( smoking , diet , exercise ) .", "sentence_id": 2}
+{"abstract_id": "24333157", "label": "methods", "text": "Poisson regression models among completers ( N = @ ) were conducted adjusting for age , education , smoking status and depression .", "sentence_id": 3}
+{"abstract_id": "24333157", "label": "results", "text": "Intervention participants had more days/week following a healthy eating plan -LSB- relative rate = @ , @ % confidence interval ( CI ) = @-@ @ -RSB- and more days of participation in @ min of physical activity ( relative rate = @ , @ % CI = @-@ @ ) compared to usual care .", "sentence_id": 4}
+{"abstract_id": "24333157", "label": "results", "text": "Intervention participants were more likely to meet physical activity guidelines ( @ % increase ) compared to usual care ( @ % decrease ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24333157", "label": "conclusions", "text": "Diet and activity generally improved for those receiving the intervention , while there were no differences in some aspects of diet ( fruit and vegetable and high-fat food intake ) , smoking status and sitting time between conditions in the TEAMcare trial .", "sentence_id": 6}
+{"abstract_id": "25252721", "label": "background", "text": "The @ American Heart Association guidelines suggested an increase in cardiopulmonary resuscitation compression depth with a target > @ mm and no upper limit .", "sentence_id": 0}
+{"abstract_id": "25252721", "label": "background", "text": "This target is based on limited evidence , and we sought to determine the optimal compression depth range .", "sentence_id": 1}
+{"abstract_id": "25252721", "label": "results", "text": "We studied emergency medical services-treated out-of-hospital cardiac arrest patients from the Resuscitation Outcomes Consortium Prehospital Resuscitation Impedance Valve and Early Versus Delayed Analysis clinical trial and the Epistry-Cardiac Arrest database .", "sentence_id": 2}
+{"abstract_id": "25252721", "label": "results", "text": "We calculated adjusted odds ratios for survival to hospital discharge , @-day survival , and any return of circulation .", "sentence_id": 3}
+{"abstract_id": "25252721", "label": "results", "text": "We included @ adult patients from @ US and Canadian cities with a mean age of @ years , mean compression depth of @ mm , and a return of circulation of @ % , @-day survival of @ % , and survival to hospital discharge of @ % .", "sentence_id": 4}
+{"abstract_id": "25252721", "label": "results", "text": "For survival to discharge , the adjusted odds ratios were @ ( @ % CI , @-@ @ ) for each @-mm increment in compression depth , @ ( @ % CI , @-@ @ ) for cases within @ depth range ( > @ mm ) , and @ ( @ % CI , @-@ @ ) for percentage of minutes in depth range ( @ % change ) .", "sentence_id": 5}
+{"abstract_id": "25252721", "label": "results", "text": "Covariate-adjusted spline curves revealed that the maximum survival is at a depth of @ mm ( @-mm interval with highest survival between @ and @ mm ) with no differences between men and women .", "sentence_id": 6}
+{"abstract_id": "25252721", "label": "conclusions", "text": "This large study of out-of-hospital cardiac arrest patients demonstrated that increased cardiopulmonary resuscitation compression depth is strongly associated with better survival .", "sentence_id": 7}
+{"abstract_id": "25252721", "label": "conclusions", "text": "Our adjusted analyses , however , found that maximum survival was in the depth interval of @ to @ mm ( peak , @ mm ) , suggesting that the @ American Heart Association cardiopulmonary resuscitation guideline target may be too high .", "sentence_id": 8}
+{"abstract_id": "24494277", "label": "objective", "text": "To compare the efficacy differences between acupuncture combined with auricular point sticking therapy and clomiphene oral administration in the treatment of polycystic ovary syndrome ( PCOS ) .", "sentence_id": 0}
+{"abstract_id": "24494277", "label": "methods", "text": "One hundred cases of PCOS were randomized into two groups , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "24494277", "label": "methods", "text": "Acupuncture com bined with auricular point sticking group ( group A ) : acupuncture was applied at Guanyuan ( CV @ ) , Zhongji ( CV @ ) and Zigong ( EX-CA @ ) , once daily ; auricular point sticking was applied at Spleen ( pi , CO@ ) , Endocrine ( neifenmi , CO@ ) , Unterus and Kidney ( shen , CO@ ) , t he plaster was changed once a week .", "sentence_id": 2}
+{"abstract_id": "24494277", "label": "methods", "text": "Clomiphene grou p ( group B ) : oral clomiphene was prescribed at the @th day of the menstrual , for @ consecutive days , totally @ menstrual cycles was needed .", "sentence_id": 3}
+{"abstract_id": "24494277", "label": "methods", "text": "The ovulation induction , pregnancy and menstruation resuming of patients in the two ' , The totally effective rate was @ % ( @/@ ) in group A , which was group were observed and compared .", "sentence_id": 4}
+{"abstract_id": "24494277", "label": "results", "text": "The totally effective rate was @ % ( @/@ ) in group A , which was superior to @ % ( @/@ ) in group B ( P < @ ) ; the ovulation rate and pregnancy rate were @ % ( @/@ ) and @ % ( @/@ ) in group A , whiche were superior to that of group B ( all P < @ ) ; the menstruation resuming rate was @ ( @/@ ) in group A , which was superior to @ ( @/@ ) in group B ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24494277", "label": "results", "text": "No adverse effect was observed in group A , while in group B , varying degrees of nausea , vomiting , headache and dermatitis were observed in @ cases , ovarian hyperstimulation syndrome ( OHSS ) like polycystic ovary was observed in @ cases under the B ultrasound .", "sentence_id": 6}
+{"abstract_id": "24494277", "label": "conclusions", "text": "Acupuncture combined with auricular point sticking therapy has a better effect than clomiphene in the treatment of PCOS without any adverse effect .", "sentence_id": 7}
+{"abstract_id": "24315572", "label": "background", "text": "Former sleep studies among non-treatment seeking chronic cocaine users had captured polysomnographic changes for as long as three weeks of abstinence .", "sentence_id": 0}
+{"abstract_id": "24315572", "label": "methods", "text": "@ cocaine dependent participants , randomized to placebo in an ongoing clinical trial , received @ days of inpatient substance abuse treatment followed by @ weeks of outpatient cognitive behavioral therapy .", "sentence_id": 1}
+{"abstract_id": "24315572", "label": "methods", "text": "Polysomnographic recording was performed on consecutive nights during the @st and @nd inpatient and @rd and @th outpatient weeks .", "sentence_id": 2}
+{"abstract_id": "24315572", "label": "methods", "text": "Number of days abstinent was determined from thrice weekly urine toxicology and self-report .", "sentence_id": 3}
+{"abstract_id": "24315572", "label": "methods", "text": "Polysomnographic sleep was compared between study week @ and @ , using paired t-tests .", "sentence_id": 4}
+{"abstract_id": "24315572", "label": "methods", "text": "Trajectory of total sleep time ( TST ) was modeled both as a linear and a quadratic function of days abstinent .", "sentence_id": 5}
+{"abstract_id": "24315572", "label": "results", "text": "Despite reporting an improvement in overall sleep quality , polysomnographic sleep worsened from week @ to @ .", "sentence_id": 6}
+{"abstract_id": "24315572", "label": "results", "text": "Among all participants , TST and stage @ sleep time decreased , while REM sleep latency increased .", "sentence_id": 7}
+{"abstract_id": "24315572", "label": "results", "text": "Among participants who began the study with a positive urine test , there was also a decrease in REM and a trend for decreased slow wave sleep .", "sentence_id": 8}
+{"abstract_id": "24315572", "label": "results", "text": "TST compared to number of days abstinent ( up to @ days ) was best fit with a quadratic model ( p = @ ) , suggesting the possibility of an improvement in total sleep time with extended abstinence .", "sentence_id": 9}
+{"abstract_id": "24315572", "label": "conclusions", "text": "This is the first polysomnographic characterization of sleep in a large sample of cocaine users in treatment .", "sentence_id": 10}
+{"abstract_id": "24315572", "label": "conclusions", "text": "Present findings confirm earlier results of poor and deteriorating sleep early in abstinence , and raise the possibility of improvement after an extended abstinence .", "sentence_id": 11}
+{"abstract_id": "25695686", "label": "objective", "text": "Assessment of differences in soft tissue healing and long-term issues between two techniques for bone-anchored hearing implant ( BAHI ) surgery .", "sentence_id": 0}
+{"abstract_id": "25695686", "label": "methods", "text": "Single-center , randomized , nonblinded study using balanced randomization ( @:@ ) .", "sentence_id": 1}
+{"abstract_id": "25695686", "label": "methods", "text": "Tertiary referral center in the Central Denmark Region .", "sentence_id": 2}
+{"abstract_id": "25695686", "label": "methods", "text": "Forty-seven adults with normal skin quality .", "sentence_id": 3}
+{"abstract_id": "25695686", "label": "methods", "text": "Operation with a BAHI system with randomization to @ ) dermatome technique with soft tissue removal and @ ) linear incision with no soft tissue reduction .", "sentence_id": 4}
+{"abstract_id": "25695686", "label": "methods", "text": "Holgers ' score , pain , and sensibility loss assessed at @ , @ , @ , @ , @ , and @ days and @ , @ , @ , and @ months postoperatively .", "sentence_id": 5}
+{"abstract_id": "25695686", "label": "methods", "text": "Implant loss .", "sentence_id": 6}
+{"abstract_id": "25695686", "label": "results", "text": "Forty-nine patients were randomized ( linear incision , n = @ ; dermatome , n = @ ) .", "sentence_id": 7}
+{"abstract_id": "25695686", "label": "results", "text": "Forty-seven patients were analyzed ( linear incision , n = @ ; dermatome , n = @ ) .", "sentence_id": 8}
+{"abstract_id": "25695686", "label": "results", "text": "Differences in proportions for grouped data ( outcome @ and outcome > @ ) for the total of all visits were Holgers ' Index : @ ( p = @ ; @ % confidence interval -LSB- @ % CI -RSB- , @-@ @ ) ; sensibility loss : @ ( p = @ @ ; @ % CI , @-@ @ ) ; pain : @ ( p = @ ; @ % CI , @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25695686", "label": "results", "text": "Soft tissue reactions and pain were most prominent in the early postoperative period , whereas issues with sensibility loss subsided throughout the @-year follow-up period .", "sentence_id": 10}
+{"abstract_id": "25695686", "label": "results", "text": "No implants were lost .", "sentence_id": 11}
+{"abstract_id": "25695686", "label": "conclusions", "text": "In a randomized trial for BAHI surgery , the linear incision with no subcutaneous reduction had a faster healing time and inflicted less pain and sensibility loss than the dermatome technique .", "sentence_id": 12}
+{"abstract_id": "25695686", "label": "conclusions", "text": "The long-term soft tissue problems were similar in the two groups , thus favoring the linear incision , which is less invasive .", "sentence_id": 13}
+{"abstract_id": "25047649", "label": "objective", "text": "The combined IVGTT-hyperinsulinaemic-euglycaemic clamp ( Botnia clamp ) allows the assessment of insulin secretion and sensitivity in one experiment .", "sentence_id": 0}
+{"abstract_id": "25047649", "label": "objective", "text": "It remains unclear whether this clamp yields results comparable with those of the standard hyperinsulinaemic-euglycaemic clamp ( SHEC ) in diabetes patients .", "sentence_id": 1}
+{"abstract_id": "25047649", "label": "objective", "text": "We hypothesised that the IVGTT induces responses affecting insulin sensitivity assessment .", "sentence_id": 2}
+{"abstract_id": "25047649", "label": "methods", "text": "Of @ randomised diet - or metformin-treated patients with well-controlled type @ diabetes , @ randomly underwent a Botnia clamp and an SHEC , spaced by @ weeks , in one clinical research centre in a crossover study .", "sentence_id": 3}
+{"abstract_id": "25047649", "label": "methods", "text": "The main outcomes were whole-body and hepatic insulin sensitivity as measured by the clamp and -LSB- @,@ - ( @ ) H@ -RSB- glucose .", "sentence_id": 4}
+{"abstract_id": "25047649", "label": "methods", "text": "Substrate utilisation was assessed from indirect calorimetry and beta cell function from insulin dynamics during IVGTT .", "sentence_id": 5}
+{"abstract_id": "25047649", "label": "results", "text": "The values of whole-body insulin sensitivity obtained from Botnia clamp and SHEC were correlated ( r = @ , p < @ ) , but also revealed intra-individual variations .", "sentence_id": 6}
+{"abstract_id": "25047649", "label": "results", "text": "Hepatic insulin sensitivity did not differ between experiments during the clamp , but differed after IVGTT .", "sentence_id": 7}
+{"abstract_id": "25047649", "label": "results", "text": "The contribution of glucose oxidation to glucose disposal increased by @ @ and @ @ mg kg fat-free mass ( FFM ) ( -@ ) min ( -@ ) ( Botnia and SHEC , p < @ ) , whereas lipid oxidation decreased by @ @ and @ @ mg kg FFM ( -@ ) min ( -@ ) ( p < @ ) from baseline .", "sentence_id": 8}
+{"abstract_id": "25047649", "label": "results", "text": "Differences in NEFA ( r = -@ , p < @ ) , but not C-peptide ( r = -@ , p = @ ) or hepatic insulin sensitivity between IVGTT and placebo before the clamps correlated with individual variations of insulin sensitivity .", "sentence_id": 9}
+{"abstract_id": "25047649", "label": "conclusions", "text": "The Botnia clamp provides similar estimates of insulin sensitivity as SHEC in patients with type @ diabetes , but changes in NEFA during IVGTT may affect insulin sensitivity and thereby the discrimination between insulin-sensitive and insulin-resistant individuals .", "sentence_id": 10}
+{"abstract_id": "25194408", "label": "background", "text": "Clinical studies of recent years have shown that hyperuricemia is associated with poor outcomes such as cardiovascular mortality and dialysis inadequacy in patients undergoing hemodialysis .", "sentence_id": 0}
+{"abstract_id": "25194408", "label": "background", "text": "Our study investigated the effect of vitamin C supplementation on serum uric acid levels in hemodialysis patients .", "sentence_id": 1}
+{"abstract_id": "25194408", "label": "methods", "text": "This randomized placebo-controlled trial was conducted on @ hemodialysis patients .", "sentence_id": 2}
+{"abstract_id": "25194408", "label": "methods", "text": "They were randomly divided into the intervention group , to receive @ mg of vitamin C , three times per week , for @ weeks , and control groups @ and @ , to receive placebo injection ( saline ) and no intervention , respectively .", "sentence_id": 3}
+{"abstract_id": "25194408", "label": "methods", "text": "Serum levels of uric acid and creatinine were measured at the start of the study and also after @ weeks .", "sentence_id": 4}
+{"abstract_id": "25194408", "label": "results", "text": "The mean of serum levels of uric acid was @ @ mg/dL ( reference range , @ mg/dL to @ mg/dL ) .", "sentence_id": 5}
+{"abstract_id": "25194408", "label": "results", "text": "Nearly , half of the patients ( @ % ) had a serum level of uric acid greater than @ mg/dL .", "sentence_id": 6}
+{"abstract_id": "25194408", "label": "results", "text": "The median baseline serum levels of uric acid were @ mg/dL , @ mg/dL , and @ mg/dL in the intervention , control @ , and control @ groups , respectively ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25194408", "label": "results", "text": "After @ months , median levels reduced significantly in the vitamin C group to @ mg/dL as compared to @ mg/dL and @ mg/dL in control groups ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25194408", "label": "results", "text": "The mean serum creatinine level had no significant changes during the study .", "sentence_id": 9}
+{"abstract_id": "25194408", "label": "conclusions", "text": "Our results demonstrated the existence of a significant negative relationship between vitamin C and serum uric acid levels .", "sentence_id": 10}
+{"abstract_id": "25194408", "label": "conclusions", "text": "Detailed investigations with larger sample sizes and longer-term use of vitamin C are recommended .", "sentence_id": 11}
+{"abstract_id": "25535985", "label": "objective", "text": "This prospective long-term follow-up study evaluated the effects of half-dose etanercept ( @ mg weekly ) on clinical remission and radiographic progression in a large cohort of patients with rheumatoid arthritis ( RA ) in clinical remission after etanercept @ mg bi-weekly .", "sentence_id": 0}
+{"abstract_id": "25535985", "label": "methods", "text": "@ biologic-nave RA patients were treated with etanercept @ mg bi-weekly after failure of conventional drugs .", "sentence_id": 1}
+{"abstract_id": "25535985", "label": "methods", "text": "Patients achieving remission ( DAS@ < @ ) for @ months were randomised to receive etanercept @ mg weekly or @ mg bi-weekly .", "sentence_id": 2}
+{"abstract_id": "25535985", "label": "methods", "text": "Patients were assessed at baseline and every @ weeks .", "sentence_id": 3}
+{"abstract_id": "25535985", "label": "methods", "text": "Remission rates , radiographic progression , incidence of infections and costs of the regimens were compared .", "sentence_id": 4}
+{"abstract_id": "25535985", "label": "results", "text": "After a mean follow-up of @ months , @ patients ( @ % ) achieved DAS@ remission ; @ were randomised to one of two dose regimens : etanercept @ weekly ( group A , @ patients ) and etanercept @ mg bi-weekly ( group B , @ patients ) .", "sentence_id": 5}
+{"abstract_id": "25535985", "label": "results", "text": "At the end of follow-up , @ % patients of group A maintained remission for a mean of @ years .", "sentence_id": 6}
+{"abstract_id": "25535985", "label": "results", "text": "Radiographic progression occurred in a small number of patients of group A and the rate of radiographic progression ( TSS > @ ) was not significantly different in the two groups ( @ % vs. @ % after the first year and @ % vs. @ % after the second year , respectively ) .", "sentence_id": 7}
+{"abstract_id": "25535985", "label": "results", "text": "The incidence ratio of severe infections was @ / @ patient-years in group A. Etanercept half-dose regimen resulted in a saving of @ with a cost saving up to @ per year .", "sentence_id": 8}
+{"abstract_id": "25535985", "label": "conclusions", "text": "Clinical remission and arrest of radiographic progression persisted in a substantial percentage of patients with RA even after reduction of standard-dose etanercept .", "sentence_id": 9}
+{"abstract_id": "24318410", "label": "background", "text": "Acute appendicitis is the most common reason for abdominal surgery in young adults and children .", "sentence_id": 0}
+{"abstract_id": "24318410", "label": "background", "text": "Open appendectomy is still the treatment often chosen because it is simple , safe , and effective .", "sentence_id": 1}
+{"abstract_id": "24318410", "label": "background", "text": "Our aim was to study whether cosmetic results of appendectomy wounds are better after using continuous absorbable intradermal ( A ) sutures compared with wound closure with interrupted nonabsorbable ( NA ) sutures .", "sentence_id": 2}
+{"abstract_id": "24318410", "label": "methods", "text": "A total of @ adult patients with clinically suspected appendicitis were allocated to the study and prospectively randomized into two wound-closure groups : the interrupted NA suture group and the A suture group .", "sentence_id": 3}
+{"abstract_id": "24318410", "label": "methods", "text": "Of these , @ patients with sufficient data were invited to the outpatient clinic for cosmetic analysis .", "sentence_id": 4}
+{"abstract_id": "24318410", "label": "methods", "text": "Cosmetic results were evaluated after a median of @ months .", "sentence_id": 5}
+{"abstract_id": "24318410", "label": "methods", "text": "For subjective scar assessment , the Vancouver scar scale , the patient and observer scar assessment scale ( POSAS ) , and a visual analog scale ( VAS ) were used .", "sentence_id": 6}
+{"abstract_id": "24318410", "label": "methods", "text": "Objective evaluation was carried out by measuring surface area , average width , and estimated concentration change ( ECC ) of hemoglobin and melanin in the scar using spectrocutometry .", "sentence_id": 7}
+{"abstract_id": "24318410", "label": "methods", "text": "For statistical analyses we used the Mann-Whitney test and Student 's t test .", "sentence_id": 8}
+{"abstract_id": "24318410", "label": "results", "text": "Both objective and subjective analyses showed better cosmetic results for absorbable intradermal suturing .", "sentence_id": 9}
+{"abstract_id": "24318410", "label": "results", "text": "The difference between the two groups was statistically significant as regards POSAS in both patient ( p = @ ) and observer scales ( p = @ ) , and VAS ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24318410", "label": "results", "text": "Scar surface area was significantly smaller in group A than in group NA ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24318410", "label": "results", "text": "ECC measurements showed higher values for melanin in group NA than in group A ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24318410", "label": "conclusions", "text": "Continuous intradermal absorbable suturing yields a better cosmetic result than interrupted nonabsorbable suturing in lower abdominal transverse appendectomy .", "sentence_id": 13}
+{"abstract_id": "24445098", "label": "objective", "text": "We investigated @ approaches for implementing the Chronic Care Model to improve diabetes care : ( @ ) practice facilitation over @ months using a reflective adaptive process ( RAP ) approach ; ( @ ) practice facilitation for up to @ months using a continuous quality improvement ( CQI ) approach ; and ( @ ) providing self-directed ( SD ) practices with model information and resources , without facilitation .", "sentence_id": 0}
+{"abstract_id": "24445098", "label": "methods", "text": "We conducted a cluster-randomized trial , called Enhancing Practice , Improving Care ( EPIC ) , that compared these approaches among @ small to midsized primary care practices .", "sentence_id": 1}
+{"abstract_id": "24445098", "label": "methods", "text": "At baseline and @ months and @ months after enrollment , we assessed practice diabetes quality measures from chart audits and Practice Culture Assessment scores from clinician and staff surveys .", "sentence_id": 2}
+{"abstract_id": "24445098", "label": "results", "text": "Although measures of the quality of diabetes care improved in all @ groups ( all P < @ ) , improvement was greater in CQI practices compared with both SD practices ( P < @ ) and RAP practices ( P < @ ) ; additionally , improvement was greater in SD practices compared with RAP practices ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24445098", "label": "results", "text": "In RAP practices , Change Culture scores showed a trend toward improvement at @ months ( P = @ ) but decreased below baseline at @ months ( P < @ ) , while Work Culture scores decreased from @ to @ months ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24445098", "label": "results", "text": "Both scores were stable over time in SD and CQI practices .", "sentence_id": 5}
+{"abstract_id": "24445098", "label": "conclusions", "text": "Traditional CQI interventions are effective at improving measures of the quality of diabetes care , but may not improve practice change and work culture .", "sentence_id": 6}
+{"abstract_id": "24445098", "label": "conclusions", "text": "Short-term practice facilitation based on RAP principles produced less improvement in quality measures than CQI or SD interventions and also did not produce sustained improvements in practice culture .", "sentence_id": 7}
+{"abstract_id": "25240168", "label": "objective", "text": "Intracoronary thrombus is disrupted by stent deployment and confounded by the development of intrastent plaque prolapse .", "sentence_id": 0}
+{"abstract_id": "25240168", "label": "objective", "text": "This study aims at investigating the feasibility and repeatability of thrombus quantification prior to stent implantation using optical coherence tomography ( OCT ) in ST-segment elevation myocardial infarction ( STEMI ) patients .", "sentence_id": 1}
+{"abstract_id": "25240168", "label": "results", "text": "Patients were enrolled in an OCT substudy of the TOTAL trial ( a randomized trial of routine aspiration ThrOmbecTomy with PCI vs. PCI ALone in patients with STEMI undergoing primary PCI ) of aspiration thrombectomy or percutaneous coronary intervention ( PCI ) alone in primary PCI ( PPCI ) of STEMI .", "sentence_id": 2}
+{"abstract_id": "25240168", "label": "results", "text": "Using OCT , thrombus burden ( TB ) and other measures of pre - and post-stent atherothrombus were analysed over the arterial segment defined by the final stent length .", "sentence_id": 3}
+{"abstract_id": "25240168", "label": "results", "text": "Feasibility was @ % ( @/@ patients ) for both pre - and post-stent OCT imaging .", "sentence_id": 4}
+{"abstract_id": "25240168", "label": "results", "text": "Altogether , @ OCT cross-sections were analysed .", "sentence_id": 5}
+{"abstract_id": "25240168", "label": "results", "text": "In Bland-Altman analyses of inter-observer variation ( n = @ ) , the mean pre-stent TB was @ % for Observer @ and @ % for Observer @ ( limits of agreement -@ to @ % ) .", "sentence_id": 6}
+{"abstract_id": "25240168", "label": "results", "text": "In Bland-Altman analyses of intra-observer variation ( n = @ ) , the mean pre-stent TB was @ % for the first and @ % for the second round of analysis by Observer @ ( limits of agreement -@ to @ % ) .", "sentence_id": 7}
+{"abstract_id": "25240168", "label": "results", "text": "There was a good correlation between pre-stent TB and pre-stent quadrants with thrombus/mm ( r = @ ) , but only modest correlation between pre-stent TB and post-stent atherothrombotic burden ( ATB ; r = @ ) .", "sentence_id": 8}
+{"abstract_id": "25240168", "label": "conclusions", "text": "Measurement of pre-stent TB by OCT during the PPCI of STEMI is feasible and highly repeatable .", "sentence_id": 9}
+{"abstract_id": "25240168", "label": "conclusions", "text": "Pre-stent TB is only modestly correlated with post-stent ATB , which indicates that pre-stent measurements might be of additional value when assessing the TB in STEMI .", "sentence_id": 10}
+{"abstract_id": "24866279", "label": "objective", "text": "The aim of this study was to investigate the degree of correlation between the Pelvic Organ Quantification system ( POP-Q ) measurements and symptom questionnaire scores before and after surgery .", "sentence_id": 0}
+{"abstract_id": "24866279", "label": "objective", "text": "This was a part of a randomized controlled study comparing conventional colporrhaphy with mesh repair surgery .", "sentence_id": 1}
+{"abstract_id": "24866279", "label": "methods", "text": "The correlation between POP-Q measurements and Pelvic Floor Impact Questionnaire ( PFIQ-@ ) and Pelvic Floor Distress Inventory ( PFDI-@ ) scores was investigated in @ women @ years or older scheduled for primary anterior vaginal wall prolapse surgery at baseline and the correlation between the change in point Ba and scores following surgery .", "sentence_id": 2}
+{"abstract_id": "24866279", "label": "methods", "text": "Statistical analyses used McNemar 's and Wilcoxon signed-rank tests , Spearman 's rank-order correlation , and multiple linear regression .", "sentence_id": 3}
+{"abstract_id": "24866279", "label": "results", "text": "Surgery significantly improved POP-Q , PFIQ-@ , and PFDI-@ scores , including subscales .", "sentence_id": 4}
+{"abstract_id": "24866279", "label": "results", "text": "We observed weak correlations between POP-Q and PFIQ-@ , including subscales ( r @-@ @ , p < @ ) , and PFDI-@ , including the Pelvic Organ Prolapse Distress Inventory ( POPDI ) subscale ( r @-@ @ , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24866279", "label": "results", "text": "Regression analysis demonstrated a significant relationship between point Ba and PFIQ-@ ( p = @ ) and PFDI-@ ( p = @ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "24866279", "label": "results", "text": "Furthermore , we observed a significant relationship between the change in point Ba ( following surgery ) and change in scores ; point Ba following surgery was significantly correlated with symptoms of bulging ( r = @ , p < @ ) and bladder-emptying problems ( r = @ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24866279", "label": "conclusions", "text": "The weak correlation between POP-Q and urogenital symptoms based on questionnaire scores suggests that neither scoring system is optimal .", "sentence_id": 8}
+{"abstract_id": "24393344", "label": "background", "text": "Pressure ulcers are one of the most common health complaints , which often take months or years to heal , and affect patients ' morbidity and quality of life .", "sentence_id": 0}
+{"abstract_id": "24393344", "label": "background", "text": "Medical options for pressure ulcers are limited .", "sentence_id": 1}
+{"abstract_id": "24393344", "label": "background", "text": "Electroacupuncture ( EA ) has been employed to relieve the symptoms for patients with pressure ulcers , but there is limited clinical evidence for its effectiveness .", "sentence_id": 2}
+{"abstract_id": "24393344", "label": "methods", "text": "This study consists of a randomized controlled trial ( RCT ) with two parallel arms : a control group and an EA group .", "sentence_id": 3}
+{"abstract_id": "24393344", "label": "methods", "text": "Both groups will receive standard wound care ( including changing position , using mattresses and cushions , and a good diet ) of five sessions per week for a total of @ sessions during the @-week treatment period .", "sentence_id": 4}
+{"abstract_id": "24393344", "label": "methods", "text": "In addition , the EA group will receive the EA intervention .", "sentence_id": 5}
+{"abstract_id": "24393344", "label": "methods", "text": "The following outcome measurements will be used in examination of participants : wound surface area ( WSA ) , visual analogue scale ( VAS ) , and the proportion of ulcers healed within trial period ( PUHTP ) .", "sentence_id": 6}
+{"abstract_id": "24393344", "label": "methods", "text": "All the outcomes will be evaluated at the start of the study , at the end of the fourth week , at @ weeks after randomization , and @ month after treatment cessation .", "sentence_id": 7}
+{"abstract_id": "24393344", "label": "conclusions", "text": "The aim of this study is to evaluate the effectiveness of EA for the treatment of patients with pressure ulcers .", "sentence_id": 8}
+{"abstract_id": "25190674", "label": "objective", "text": "Although statins can induce coronary atheroma regression , this benefit has yet to be demonstrated in diabetic individuals .", "sentence_id": 0}
+{"abstract_id": "25190674", "label": "objective", "text": "We tested the hypothesis that high-intensity statin therapy may promote coronary atheroma regression in patients with diabetes .", "sentence_id": 1}
+{"abstract_id": "25190674", "label": "methods", "text": "The Study of Coronary Atheroma by Intravascular Ultrasound : Effect of Rosuvastatin Versus Atorvastatin ( SATURN ) used serial intravascular ultrasound measures of coronary atheroma volume in patients treated with rosuvastatin @ mg or atorvastatin @ mg for @ months .", "sentence_id": 2}
+{"abstract_id": "25190674", "label": "methods", "text": "This analysis compared changes in biochemistry and coronary percent atheroma volume ( PAV ) in patients with ( n = @ ) and without ( n = @ ) diabetes .", "sentence_id": 3}
+{"abstract_id": "25190674", "label": "results", "text": "At baseline , patients with diabetes had lower LDL cholesterol ( LDL-C ) and HDL cholesterol ( HDL-C ) levels but higher triglyceride and CRP levels compared with patients without diabetes .", "sentence_id": 4}
+{"abstract_id": "25190674", "label": "results", "text": "At follow-up , diabetic patients had lower levels of LDL-C ( @ @ vs. @ @ mg/dL , P = @ ) and HDL-C ( @ @ vs. @ @ mg/dL , P < @ ) but higher levels of triglycerides ( @ -LSB- @ , @ -RSB- vs. @ mg/dL -LSB- @ , @ -RSB- , P = @ ) and CRP ( @ -LSB- @ , @ -RSB- vs. @ -LSB- @ , @ -RSB- mg/L , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25190674", "label": "results", "text": "Both patients with and without diabetes demonstrated regression of coronary atheroma as measured by change in PAV ( -@ @ vs. -@ @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25190674", "label": "results", "text": "PAV regression was less in diabetic compared with nondiabetic patients when on-treatment LDL-C levels were > @ mg/dL ( -@ @ vs. -@ @ % , P = @ ) but similar when LDL-C levels were @ mg/dL ( -@ @ vs. -@ @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25190674", "label": "conclusions", "text": "High-intensity statin therapy alters the progressive nature of diabetic coronary atherosclerosis , yielding regression of disease in diabetic and nondiabetic patients .", "sentence_id": 8}
+{"abstract_id": "25536736", "label": "objective", "text": "To evaluate the effects of different intracorporeal ligation techniques with titanium clips , Plasma Trisector ( Gyrus , USA ) ( PTG ) , and surgical silk on bilateral laparoscopic varicocelectomy ( LPVx ) .", "sentence_id": 0}
+{"abstract_id": "25536736", "label": "methods", "text": "Between May @ and August @ , @ patients who underwent bilateral LPVx were evaluated .", "sentence_id": 1}
+{"abstract_id": "25536736", "label": "methods", "text": "The demographic parameters of patients , preoperative radiological findings , semen analysis , operative data , and follow-up were recorded .", "sentence_id": 2}
+{"abstract_id": "25536736", "label": "methods", "text": "All of the patients were divided into @ groups , randomized prospectively .", "sentence_id": 3}
+{"abstract_id": "25536736", "label": "methods", "text": "The patients whose veins were ligated by @-mm titanium clips were included in group I , those whose veins were ligated by PTG were included in group II , and those whose veins were ligated by surgical silk were included in group III .", "sentence_id": 4}
+{"abstract_id": "25536736", "label": "methods", "text": "The recorded data of the groups were analyzed .", "sentence_id": 5}
+{"abstract_id": "25536736", "label": "results", "text": "Mean follow-up time was @ + @ months .", "sentence_id": 6}
+{"abstract_id": "25536736", "label": "results", "text": "According to the demographics of age , body mass index , spermiogram , and diameter of veins before surgery , there were no statistical differences between any of the groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25536736", "label": "results", "text": "However , operation time was longer in group III ( P < @ ) , while total numbers ofligated veins did not differ among the groups ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "25536736", "label": "results", "text": "Additionally , hospital stay , oral intake , and complications were not different among the groups ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25536736", "label": "results", "text": "In follow-up the sperm count analysis was higher than the preoperative count analysis for all of the groups ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25536736", "label": "conclusions", "text": "PTG may provide a shorter operation time than using titanium clips and/or surgical silk in LPVx .", "sentence_id": 11}
+{"abstract_id": "25536736", "label": "conclusions", "text": "Additionally , PTG may increase sperm count with fewer complications than the other ligation techniques in LPVx .", "sentence_id": 12}
+{"abstract_id": "25536736", "label": "conclusions", "text": "Therefore , PTG may be the new candidate electrosurgical standard device for LPVx in the nearby future .", "sentence_id": 13}
+{"abstract_id": "25230038", "label": "objective", "text": "To compare the level of anxiety and performance of nursing students when performing a clinical simulation through the traditional method of assessment with the presence of an evaluator and through a filmed assessment without the presence of an evaluator .", "sentence_id": 0}
+{"abstract_id": "25230038", "label": "methods", "text": "Controlled trial with the participation of Brazilian public university @ students who were randomly assigned to one of two groups : a ) assessment through the traditional method with the presence of an evaluator ; or b ) filmed assessment .", "sentence_id": 1}
+{"abstract_id": "25230038", "label": "methods", "text": "The level of anxiety was assessed using the Zung test and performance was measured based on the number of correct answers .", "sentence_id": 2}
+{"abstract_id": "25230038", "label": "results", "text": "Averages of @ and @ were obtained on the anxiety scale by the group assessed through the traditional method before and after the simulation , respectively , while the filmed group obtained averages of @ and @ ; the final scores correspond to mild anxiety .", "sentence_id": 3}
+{"abstract_id": "25230038", "label": "results", "text": "Even though there was a statistically significant reduction in the intra-groups scores before and after the simulation , there was no difference between the groups .", "sentence_id": 4}
+{"abstract_id": "25230038", "label": "results", "text": "As for the performance assessments in the clinical simulation , the groups obtained similar percentages of correct answers ( @ % in the traditional assessment and @ % in the filmed assessment ) without statistically significant differences .", "sentence_id": 5}
+{"abstract_id": "25230038", "label": "conclusions", "text": "Filming can be used and encouraged as a strategy to assess nursing undergraduate students .", "sentence_id": 6}
+{"abstract_id": "24496455", "label": "background", "text": "We aimed to evaluate whether oral anticoagulants ( OACs ) alter faecal immunochemical test ( FIT ) performance in average-risk colorectal cancer ( CRC ) screening .", "sentence_id": 0}
+{"abstract_id": "24496455", "label": "methods", "text": "Individuals aged @-@ years were invited to receive one FIT sample ( cutoff @ ng ml ( -@ ) ) between November @ and June @ .", "sentence_id": 1}
+{"abstract_id": "24496455", "label": "results", "text": "Faecal immunochemical test was positive in @ % ( @ out of @ ) of users of OAC and @ % ( @ out of @ ) of non-users ( P-trend = @ ) .", "sentence_id": 2}
+{"abstract_id": "24496455", "label": "results", "text": "The positive predictive value ( PPV ) for advanced neoplasia ( AN ) in non-users was @ % vs @ % in users ( odds ratio , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24496455", "label": "results", "text": "The PPV for AN in OAC more antiplatelets ( aspirin or clopidogrel ) was @ % ( odds ratio , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24496455", "label": "conclusions", "text": "Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program .", "sentence_id": 5}
+{"abstract_id": "24496455", "label": "conclusions", "text": "The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets .", "sentence_id": 6}
+{"abstract_id": "24738550", "label": "background", "text": "Virtual patients ( VPs ) offer valuable alternative encounters when live patients with rare conditions , such as cranial nerve ( CN ) palsies , are unavailable ; however , little is known regarding simulation and optimal social learning context .", "sentence_id": 0}
+{"abstract_id": "24738550", "label": "objective", "text": "Compare learning outcomes and perspectives between students interacting with VPs in individual and team contexts .", "sentence_id": 1}
+{"abstract_id": "24738550", "label": "methods", "text": "Seventy-eight medical students were randomly assigned to interview and examine four VPs with possible CN damage either as individuals or in three-person teams , using Neurological Examination Rehearsal Virtual Environment ( NERVE ) .", "sentence_id": 2}
+{"abstract_id": "24738550", "label": "methods", "text": "Learning was measured through diagnosis accuracy and pre - / post-simulation knowledge scores .", "sentence_id": 3}
+{"abstract_id": "24738550", "label": "methods", "text": "Perspectives of learning context were collected post-simulation .", "sentence_id": 4}
+{"abstract_id": "24738550", "label": "results", "text": "Students in teams submitted correct diagnoses significantly more often than students as individuals for CN-IV ( p = @ ; team = @ % ; individual = @ % ) and CN-VI ( p = @ ; team = @ % ; individual = @ % ) .", "sentence_id": 5}
+{"abstract_id": "24738550", "label": "results", "text": "Knowledge scores increased significantly in both contexts ( p < @ ) ; however , a significant aptitude-treatment interaction effect was observed ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24738550", "label": "results", "text": "At pre-test scores @ % , students in teams scored significantly higher ( @ % ) than students as individuals ( @ % ) at post-test ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24738550", "label": "results", "text": "Students recommended implementing future NERVE exercises in teams over five other modality-timing combinations .", "sentence_id": 8}
+{"abstract_id": "24738550", "label": "conclusions", "text": "Results allow us to define best practices for integrating VP simulators into medical education .", "sentence_id": 9}
+{"abstract_id": "24738550", "label": "conclusions", "text": "Implementing NERVE experiences in team environments with medical students in the future may be preferable .", "sentence_id": 10}
+{"abstract_id": "25419883", "label": "background", "text": "Exercise-induced cough ( EIC ) is frequently reported by winter athletes , but this symptom is not always associated with exercise-induced bronchoconstriction ( EIB ) .", "sentence_id": 0}
+{"abstract_id": "25419883", "label": "background", "text": "The aims of this study were to determine if EIC can be inhibited or reduced with the inhalation of ipratropium , and if EIC in winter athletes is associated with EIB .", "sentence_id": 1}
+{"abstract_id": "25419883", "label": "methods", "text": "On @ visits , @ cross-country skiers ( @ males and @ females , mean age @ @ years ) performed an outdoor exercise in the winter ( @-minute warm-up , followed by a @-minute sprint ) , randomly preceded by the inhalation of ipratropium or a placebo .", "sentence_id": 2}
+{"abstract_id": "25419883", "label": "methods", "text": "A spirometry was done at baseline and @ minutes after inhalation of ipratropium or placebo .", "sentence_id": 3}
+{"abstract_id": "25419883", "label": "methods", "text": "Exercise was then performed , followed by the measurement of forced expiratory volume in @ second and the recording of the number of coughs until @ minutes after exercise .", "sentence_id": 4}
+{"abstract_id": "25419883", "label": "methods", "text": "Before and after exercise , the perception of cough intensity was evaluated using a modified Borg scale .", "sentence_id": 5}
+{"abstract_id": "25419883", "label": "results", "text": "Twelve of @ athletes who completed the study ( @ % ) were symptomatic following exercise with placebo ( number of coughs @ ) , but none developed EIB .", "sentence_id": 6}
+{"abstract_id": "25419883", "label": "results", "text": "For these athletes , the number of coughs after exercise ( mean number of coughs standard deviation : placebo , @ @ ; ipratropium , @ @ ; P value , nonsignificant ) and the maximal perception score for cough intensity ( mean Borg score standard deviation : placebo , @ @ ; ipratropium , @ @ ; P value , nonsignificant ) were not significantly different between ipratropium and placebo .", "sentence_id": 7}
+{"abstract_id": "25419883", "label": "results", "text": "A decrease in the number of coughs was observed in @ of the symptomatic athletes and an increase was observed in the other @ , resulting in a nonsignificant mean effect .", "sentence_id": 8}
+{"abstract_id": "25419883", "label": "conclusions", "text": "Ipratropium does not appear to significantly influence the number and the perception of cough following exercise .", "sentence_id": 9}
+{"abstract_id": "25419883", "label": "conclusions", "text": "Moreover , these results suggest that EIC is not mainly associated with EIB .", "sentence_id": 10}
+{"abstract_id": "25419883", "label": "conclusions", "text": "However , a subgroup of athletes seems to show a beneficial response to ipratropium , suggesting different cough responses in this population .", "sentence_id": 11}
+{"abstract_id": "24408122", "label": "objective", "text": "The Avosentan on Time to Doubling of Serum Creatinine , End Stage Renal Disease or Death ( ASCEND ) trial tested the renoprotective effect of the endothelin receptor antagonist avosentan in patients with diabetes and nephropathy , but the study was terminated due to an excess of congestive heart failure ( CHF ) events in the avosentan arms , likely due to fluid retention .", "sentence_id": 0}
+{"abstract_id": "24408122", "label": "objective", "text": "The aim of this study was to identify risk markers of CHF after treatment with avosentan .", "sentence_id": 1}
+{"abstract_id": "24408122", "label": "methods", "text": "In a post hoc analysis of the ASCEND trial ( N = @ participants ) , we assessed which baseline characteristics predicted CHF risk during avosentan treatment .", "sentence_id": 2}
+{"abstract_id": "24408122", "label": "methods", "text": "Furthermore , postrandomization changes between baseline and the first available measurement of body weight and hemoglobin were examined as potential clinical indicators of fluid retention for their relationship with CHF development .", "sentence_id": 3}
+{"abstract_id": "24408122", "label": "results", "text": "Relative to placebo , avosentan increased CHF risk ( hazard ratio , @ ; @ % confidence interval , @ to @ ) .", "sentence_id": 4}
+{"abstract_id": "24408122", "label": "results", "text": "The avosentan-related CHF risk was higher with lower baseline cholesterol levels ( P interaction = @ ) and concomitant statin use ( P interaction = @ ) , whereas it was lower with a lower estimated GFR ( P interaction = @ ) .", "sentence_id": 5}
+{"abstract_id": "24408122", "label": "results", "text": "Patients allocated to avosentan had a median body weight increase of @ kg ( interquartile range , @ to @ kg ) and a median hemoglobin decrease of @ g/dl ( interquartile range , -@ to -@ g/dl ) at the first postrandomization measurement .", "sentence_id": 6}
+{"abstract_id": "24408122", "label": "results", "text": "The body weight increase induced by avosentan was associated with CHF development ( P interaction = @ ) , whereas hemoglobin decrease was not ( P interaction = @ ) .", "sentence_id": 7}
+{"abstract_id": "24408122", "label": "results", "text": "The increase in body weight was particularly pronounced in patients with a cardiovascular disease history and in patients using statins .", "sentence_id": 8}
+{"abstract_id": "24408122", "label": "conclusions", "text": "In avosentan-treated patients , body weight increase , but not hemoglobin decrease , was associated with CHF development , indicating that close body weight monitoring could provide an early signal of CHF development in future trials with endothelin receptor antagonists .", "sentence_id": 9}
+{"abstract_id": "24681859", "label": "objective", "text": "The aim of this study was to measure round window ( RW ) diameters in patients with congenital aural atresia ( CAA ) or sensorineural hearing loss ( SNHL ) and a normal control group and to analyze whether differences exist between these groups .", "sentence_id": 0}
+{"abstract_id": "24681859", "label": "methods", "text": "Temporal bone computed tomographic scans of @ patients with CAA ( @ males , @ females ) aged @ to @ years ( median age , @ years ) , @ patients with SNHL ( @ males , @ females ) aged @ to @ years ( median age , @ years ) , and @ patients ( @ males , @ females ) aged @ months to @ years ( median age , @ years ) randomly selected from a pool of patients with unilateral chronic otitis media or cholesteatoma were reviewed .", "sentence_id": 1}
+{"abstract_id": "24681859", "label": "methods", "text": "We measured RW diameter on oblique reconstruction planes .", "sentence_id": 2}
+{"abstract_id": "24681859", "label": "methods", "text": "To prevent possible individual differences , skull width was measured .", "sentence_id": 3}
+{"abstract_id": "24681859", "label": "results", "text": "There were no statistically significant differences between all groups for skull width .", "sentence_id": 4}
+{"abstract_id": "24681859", "label": "results", "text": "Both RW diameter and RW membrane width were found smaller in the CAA group than both SNHL group and control group with statistical significance , whereas there were no statistically significant differences between the SNHL group and the control group .", "sentence_id": 5}
+{"abstract_id": "24681859", "label": "conclusions", "text": "We found that both the RW diameter and RW membrane width in CAA were smaller than those in the control group .", "sentence_id": 6}
+{"abstract_id": "24681859", "label": "conclusions", "text": "If this finding is supported in future studies , the production of floating mass transducer with different sizes may be useful .", "sentence_id": 7}
+{"abstract_id": "24681859", "label": "conclusions", "text": "We suggest that RW diameter should be measured in each patient before operation and thus a floating mass transducer with the appropriate caliber should be chosen .", "sentence_id": 8}
+{"abstract_id": "24428092", "label": "background", "text": "New topical treatments studied in adults have been published to be potentially effective in the treatment of hypertrophic scar and keloids .", "sentence_id": 0}
+{"abstract_id": "24428092", "label": "background", "text": "There is still no study in Thai children .", "sentence_id": 1}
+{"abstract_id": "24428092", "label": "objective", "text": "To study the efficacy of @ % onion extract in silicone derivative gel for the prevention of hypertrophic scar and keloid in median sternotomy wound from open heart surgery in pediatric patients .", "sentence_id": 2}
+{"abstract_id": "24428092", "label": "methods", "text": "Thirty-nine pediatric patients who had median sternotomy were recruited in this prospective randomized , double-blinded , placebo-controlled split-scar experimental study .", "sentence_id": 3}
+{"abstract_id": "24428092", "label": "methods", "text": "The wound in each patient was divided into upper and lower parts , and the treatment with , either onion extract gel or placebo was randomly applied by block randomization onto each part of the wound twice daily after the seventh day postoperatively for six months .", "sentence_id": 4}
+{"abstract_id": "24428092", "label": "methods", "text": "The incidence of scars , serial photographs of the wound , Vancouver Scar Scale ( VSS ) , and adverse effect were assessed at each visit .", "sentence_id": 5}
+{"abstract_id": "24428092", "label": "results", "text": "Thirty patients with the mean age of @ years completed the @-month study period .", "sentence_id": 6}
+{"abstract_id": "24428092", "label": "results", "text": "Six patients ( @ % ) in onion extract gel group had no scar compared to one patient ( @ % ) in placebo group ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24428092", "label": "results", "text": "Of the @ patients with hypertrophic scar nine were from onion extract gel group and @ from the placebo group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24428092", "label": "results", "text": "Keloid was not statistically significant diferent in both groups ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24428092", "label": "results", "text": "VSS was not statistically significant different in all visits .", "sentence_id": 10}
+{"abstract_id": "24428092", "label": "results", "text": "One case had a pustule on the part of the onion extract in silicone derivative application at the sixth month .", "sentence_id": 11}
+{"abstract_id": "24428092", "label": "conclusions", "text": "Onion extract in silicone derivative gel can significantly decreased the incidence of hypertrophic scar from median sternotomy wound in pediatric patients .", "sentence_id": 12}
+{"abstract_id": "24428092", "label": "conclusions", "text": "Keloid did not show statistically significant differences in both groups .", "sentence_id": 13}
+{"abstract_id": "24782447", "label": "objective", "text": "To investigate the characteristics of residual symptoms and to evaluate the effects of adjuvant vestibular suppressants on residual symptoms after successful canalith repositioning procedures ( CRPs ) .", "sentence_id": 0}
+{"abstract_id": "24782447", "label": "methods", "text": "Individual randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24782447", "label": "methods", "text": "One hundred fifty patients with idiopathic benign paroxysmal positional vertigo who achieved successful CRPs on initial visit participated in this study .", "sentence_id": 2}
+{"abstract_id": "24782447", "label": "methods", "text": "Dizziness Handicap Inventory ( DHI ) questionnaires were completed before CRPs .", "sentence_id": 3}
+{"abstract_id": "24782447", "label": "methods", "text": "All study populations were divided into three groups after successful CRPs on the initial visit day : the medication ( V ) group ( treated with a vestibular suppressant -LSB- dimenhydrinate @ mg per day -RSB- ) , the placebo ( P ) group , and the no medication ( N ) group .", "sentence_id": 4}
+{"abstract_id": "24782447", "label": "methods", "text": "One week after successful CRPs , residual symptoms were checked and repeated DHI questionnaires were completed to compare residual symptoms .", "sentence_id": 5}
+{"abstract_id": "24782447", "label": "results", "text": "Among the @ patients who did not show positional nystagmus at follow-up , @ ( @ % ) complained of residual symptoms .", "sentence_id": 6}
+{"abstract_id": "24782447", "label": "results", "text": "The presence of residual symptoms was more prevalent in the P and N group compared with the V group ( P = @ , P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24782447", "label": "results", "text": "The most frequent residual symptom was lightheadedness ( n = @ ) .", "sentence_id": 8}
+{"abstract_id": "24782447", "label": "results", "text": "Moreover , in the V group , lightheadedness was significantly reduced compared with the P group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24782447", "label": "results", "text": "However , in the analysis of DHI , total and subscale scores did not differ across the three groups before or after successful CRP .", "sentence_id": 10}
+{"abstract_id": "24782447", "label": "conclusions", "text": "Vestibular suppressants significantly reduced residual symptoms compared to both placebo and no medication after CRP .", "sentence_id": 11}
+{"abstract_id": "24782447", "label": "conclusions", "text": "However , there was no significant reduction in DHI score compared with the control group , suggesting that the residual symptoms could not be evaluated by DHI score alone .", "sentence_id": 12}
+{"abstract_id": "25907945", "label": "objective", "text": "To study the effect of perioperative immunomodulatory therapy on postoperative recurrence of rectal cancer .", "sentence_id": 0}
+{"abstract_id": "25907945", "label": "methods", "text": "This prospective study was conducted among @ rectal/anal cancer patients undergoing intersphincteric resection at our center between January , @ and January , @ , among whom @ were eligible to be included and completed the study .", "sentence_id": 1}
+{"abstract_id": "25907945", "label": "methods", "text": "The @ patients were randomized in a double-blinded fashion into @ equal groups to receive immunomodulatory therapy with @ mg/kg celecoxib ( group A ) , @ mg/kg Sou-Medrol ( group B ) , or placebo ( group C ) , given daily from @ days before surgery to @ days after surgery , and the postoperative cancer recurrence were compared .", "sentence_id": 2}
+{"abstract_id": "25907945", "label": "results", "text": "At @ days after the operation , the @ groups showed significantly different C-reactive protein ( CRP ) levels , which decreased obviously in all the @ groups compared with those at @ day following the operation ( P = @ ) , especially in group B.", "sentence_id": 3}
+{"abstract_id": "25907945", "label": "results", "text": "The levels of interleukin-@ ( IL-@ ) at @ days after the operation also differed significantly between the @ groups but were lower in all the @ groups than those at @ day after the operation ( P = @ ) , and this reduction was the most obvious in group A. COX-@ expression differed significantly between the @ groups ( P = @ ) , among which group A showed the most obvious suppression of COX-@ expression .", "sentence_id": 4}
+{"abstract_id": "25907945", "label": "results", "text": "During the follow-up for a mean of @ months , no significant difference in the recurrence rate was found between the @ groups ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25907945", "label": "conclusions", "text": "With a lower efficacy than Sou-Medrol in decreasing postoperative inflammation , celecoxib produces a better effect in inhibiting COX-@ expression , but it does not lower postoperative recurrence rate of rectal cancer .", "sentence_id": 6}
+{"abstract_id": "24405854", "label": "background", "text": "In trials of behavioural interventions , the individuals who deliver the intervention are in a position of key influence on the success of the trial .", "sentence_id": 0}
+{"abstract_id": "24405854", "label": "background", "text": "Their fidelity to the intervention is crucial .", "sentence_id": 1}
+{"abstract_id": "24405854", "label": "background", "text": "Yet little is understood about the experiences of this group of trial personnel .", "sentence_id": 2}
+{"abstract_id": "24405854", "label": "background", "text": "This study aimed to investigate the views and experiences of educators who delivered a structured education intervention to people with type @ diabetes , which incorporated training in self-monitoring of either blood glucose ( SMBG ) or urine glucose ( SMUG ) as part of a randomized controlled trial ( RCT ) .", "sentence_id": 3}
+{"abstract_id": "24405854", "label": "methods", "text": "Educators ' views were explored through focus groups before and after training ( N = @ ) and approximately @ year into the trial ( N = @ ) , and semi-structured telephone interviews at approximately @ years ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "24405854", "label": "methods", "text": "Analysis was based on the constant comparative method .", "sentence_id": 5}
+{"abstract_id": "24405854", "label": "results", "text": "Educators held preferences regarding the intervention variants ; thus , they were not in individual equipoise .", "sentence_id": 6}
+{"abstract_id": "24405854", "label": "results", "text": "Training raised awareness of preferences and their potential to impact on delivery .", "sentence_id": 7}
+{"abstract_id": "24405854", "label": "results", "text": "Educators were confident in their unbiased delivery , but acknowledged the challenges involved .", "sentence_id": 8}
+{"abstract_id": "24405854", "label": "results", "text": "Concealing their preferences was helped by a sense of professionalism , the patient-centred nature of the intervention , and concessions in the trial protocol ( enabling participants to swap monitoring methods if needed ) .", "sentence_id": 9}
+{"abstract_id": "24405854", "label": "results", "text": "Commitment to unbiased delivery was explained through a desire for evidence-based knowledge in the contentious area of SMBG .", "sentence_id": 10}
+{"abstract_id": "24405854", "label": "conclusions", "text": "The findings provide insight into a previously unexplored group of trial personnel -- intervention deliverers in trials of behavioural interventions -- which will be useful to those designing and running similar trials .", "sentence_id": 11}
+{"abstract_id": "24405854", "label": "conclusions", "text": "Rather than individual equipoise , it is intervention deliverers ' awareness of personal preferences and their potential impact on the trial outcome that facilitates unbiased delivery .", "sentence_id": 12}
+{"abstract_id": "24405854", "label": "conclusions", "text": "Further , awareness of community equipoise , the need for evidence , and relevance to the individual enhance commitment to the RCT .", "sentence_id": 13}
+{"abstract_id": "25480457", "label": "objective", "text": "The purpose of this study is to determine whether varying the format used to present prognostic data alters the perception of risk among surrogate decision makers in the intensive care unit ( ICU ) .", "sentence_id": 0}
+{"abstract_id": "25480457", "label": "methods", "text": "This was a prospective randomized comparative trial conducted in a @-bed adult tertiary ICU .", "sentence_id": 1}
+{"abstract_id": "25480457", "label": "methods", "text": "Enrolled surrogate decision makers were randomized to @ of @ questionnaires , which presented hypothetical ICU scenarios , identical other than the format in which prognostic data were presented ( eg , frequencies vs percentages ) .", "sentence_id": 2}
+{"abstract_id": "25480457", "label": "methods", "text": "Participants were asked to rate the risk associated with each prognostic statement .", "sentence_id": 3}
+{"abstract_id": "25480457", "label": "results", "text": "We enrolled @ surrogate decision makers .", "sentence_id": 4}
+{"abstract_id": "25480457", "label": "results", "text": "The perception of risk varied significantly dependent on the presentation format .", "sentence_id": 5}
+{"abstract_id": "25480457", "label": "results", "text": "For `` quantitative data , '' risks were consistently perceived as higher , when presented as frequencies ( eg , @ in @ ) compared with equivalent percentages ( eg , @ % ) .", "sentence_id": 6}
+{"abstract_id": "25480457", "label": "results", "text": "Framing `` qualitative data '' in terms of chance of `` death '' rather than `` survival '' led to a statistically significant increase in perceived risks .", "sentence_id": 7}
+{"abstract_id": "25480457", "label": "results", "text": "Framing `` quantitative '' data in this way did not significantly affect risk perception .", "sentence_id": 8}
+{"abstract_id": "25480457", "label": "conclusions", "text": "Data format had a significant effect on how surrogate decision makers interpreted risk .", "sentence_id": 9}
+{"abstract_id": "25480457", "label": "conclusions", "text": "Qualitative statements are interpreted widely and affected by framing .", "sentence_id": 10}
+{"abstract_id": "25480457", "label": "conclusions", "text": "Where possible , multiple quantitative formats should be used for presenting prognostic information .", "sentence_id": 11}
+{"abstract_id": "24516645", "label": "objective", "text": "The training response of an intensified period of high-intensity exercise is not clear .", "sentence_id": 0}
+{"abstract_id": "24516645", "label": "objective", "text": "Therefore , we compared the cardiovascular adaptations of completing @ high-intensity aerobic interval training sessions carried out for either three or eight weeks , respectively .", "sentence_id": 1}
+{"abstract_id": "24516645", "label": "methods", "text": "Twenty-one healthy subjects ( @ years , @ females ) completed @ high-intensity training sessions throughout a time-period of either eight weeks ( moderate frequency , MF ) or three weeks ( high frequency , HF ) followed by a detraining period of nine weeks without any training .", "sentence_id": 2}
+{"abstract_id": "24516645", "label": "methods", "text": "In both groups , maximal oxygen uptake ( VO@max ) was evaluated before training , at the @ ( th ) and @ ( th ) session and four days after the final @ ( th ) training session .", "sentence_id": 3}
+{"abstract_id": "24516645", "label": "methods", "text": "In the detraining phase VO@max was evaluated after @ days and thereafter every second week for eight weeks .", "sentence_id": 4}
+{"abstract_id": "24516645", "label": "methods", "text": "Left ventricular echocardiography , carbon monoxide lung diffusion transfer factor , brachial artery flow mediated dilatation and vastus lateralis citrate maximal synthase activity was tested before and after training .", "sentence_id": 5}
+{"abstract_id": "24516645", "label": "results", "text": "The cardiovascular adaptation after HF training was delayed compared to training with MF .", "sentence_id": 6}
+{"abstract_id": "24516645", "label": "results", "text": "Four days after ending training the HF group showed no improvement ( +@ % , p = @ ) , whereas the MF group reached their highest VO@max with a @ % improvement ( p < @ : group difference p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24516645", "label": "results", "text": "The HF group reached their highest VO@max ( @ % increase , p = @ ) twelve days into the detraining period , compared to a concomitant reduction to @ % of VO@max ( p < @ ) above baseline in the MF group ( group difference p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24516645", "label": "conclusions", "text": "Both HF and MF training of high-intensity aerobic exercise improves VO@max .", "sentence_id": 9}
+{"abstract_id": "24516645", "label": "conclusions", "text": "The cardiovascular adaptation following a HF programme of high-intensity exercise is however delayed compared to MF training .", "sentence_id": 10}
+{"abstract_id": "25301035", "label": "objective", "text": "Impaired arterial function has been implicated in diabetes-related atherosclerosis , but its determinants in high-risk adults have not been well characterised .", "sentence_id": 0}
+{"abstract_id": "25301035", "label": "objective", "text": "We investigated factors associated with impaired arterial function in adults with type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "25301035", "label": "methods", "text": "Flow-mediated dilatation ( a marker of endothelial function ) and dilator response to glyceryl trinitrate ( to assess smooth muscle function ) of the brachial artery were assessed at baseline in @ patients with type @ diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes ( FIELD ) study .", "sentence_id": 2}
+{"abstract_id": "25301035", "label": "methods", "text": "Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function .", "sentence_id": 3}
+{"abstract_id": "25301035", "label": "results", "text": "Median age was @ years ( interquartile range , @-@ ; @ % male ) and duration of diabetes was @ years ( interquartile range , @-@ ) .", "sentence_id": 4}
+{"abstract_id": "25301035", "label": "results", "text": "Flow-mediated dilatation ( @ @ % , mean SEM ) was severely impaired but not significantly associated with other risk factors .", "sentence_id": 5}
+{"abstract_id": "25301035", "label": "results", "text": "Dilator responses to glyceryl trinitrate ( @ @ % ) were significantly and independently impaired in past and present cigarette smokers ( P = @ ) and in subjects with increased urinary albumin/creatinine ratio ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25301035", "label": "conclusions", "text": "In adults with type @ diabetes and known or suspected atherosclerosis , arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels .", "sentence_id": 7}
+{"abstract_id": "25482242", "label": "objective", "text": "To determine whether a home-based care coordination program focused on medication self-management would affect the cost of care to the Medicare program and whether the addition of technology , a medication-dispensing machine , would further reduce cost .", "sentence_id": 0}
+{"abstract_id": "25482242", "label": "methods", "text": "Randomized , controlled , three-arm longitudinal study .", "sentence_id": 1}
+{"abstract_id": "25482242", "label": "methods", "text": "Participant homes in a large Midwestern urban area .", "sentence_id": 2}
+{"abstract_id": "25482242", "label": "methods", "text": "Older adults identified as having difficulty managing their medications at discharge from Medicare Home Health Care ( N = @ ) .", "sentence_id": 3}
+{"abstract_id": "25482242", "label": "methods", "text": "A team consisting of advanced practice nurses ( APNs ) and registered nurses ( RNs ) coordinated care for two groups : home-based nurse care coordination ( NCC ) plus a pill organizer group and NCC plus a medication-dispensing machine group .", "sentence_id": 4}
+{"abstract_id": "25482242", "label": "methods", "text": "To measure cost , participant claims data from @ to @ were retrieved from Medicare Part A and B Standard Analytical Files .", "sentence_id": 5}
+{"abstract_id": "25482242", "label": "results", "text": "Ordinary least squares regression with covariate adjustment was used to estimate monthly dollar savings .", "sentence_id": 6}
+{"abstract_id": "25482242", "label": "results", "text": "Total Medicare costs were $ @ per month lower in the NCC plus pill organizer group ( P = @ ) than in a control group that received usual care .", "sentence_id": 7}
+{"abstract_id": "25482242", "label": "results", "text": "For participants in the study at least @ months , total Medicare costs were $ @ lower per month in the NCC plus pill organizer group ( P = @ ) than in the control group .", "sentence_id": 8}
+{"abstract_id": "25482242", "label": "results", "text": "The cost of the NCC plus pill organizer intervention was $ @ per month , yielding a net savings of $ @ per month or $ @,@ per year .", "sentence_id": 9}
+{"abstract_id": "25482242", "label": "results", "text": "The cost of the NCC plus medication-dispensing machine intervention was $ @ per month , and total Medicare costs were $ @ higher per month than in the NCC plus pill organizer group .", "sentence_id": 10}
+{"abstract_id": "25482242", "label": "conclusions", "text": "Nurse care coordination plus a pill organizer is a cost-effective intervention for frail elderly Medicare beneficiaries .", "sentence_id": 11}
+{"abstract_id": "25482242", "label": "conclusions", "text": "The addition of the medication machine did not enhance the cost effectiveness of the intervention .", "sentence_id": 12}
+{"abstract_id": "24289887", "label": "background", "text": "Numerous animal studies and clinical trials have demonstrated that erythropoietin ( EPO ) has therapeutic effects in ischemic and degenerative diseases .", "sentence_id": 0}
+{"abstract_id": "24289887", "label": "background", "text": "However , few clinical trials have investigated the effect of EPO in Parkinson 's disease ( PD ) patients .", "sentence_id": 1}
+{"abstract_id": "24289887", "label": "background", "text": "This study was an exploratory pilot study to investigate the effects of recombinant human EPO ( rhEPO ) on motor and non-motor symptoms ( NMS ) in PD patients .", "sentence_id": 2}
+{"abstract_id": "24289887", "label": "methods", "text": "A total of @ PD patients at the Hanyang University Hospital were enrolled in the study .", "sentence_id": 3}
+{"abstract_id": "24289887", "label": "methods", "text": "The participants were randomly assigned to rhEPO and placebo groups .", "sentence_id": 4}
+{"abstract_id": "24289887", "label": "methods", "text": "The rhEPO group was infused intravenously ( @,@ IU each ) twice a week for @ weeks .", "sentence_id": 5}
+{"abstract_id": "24289887", "label": "methods", "text": "Clinical improvement was estimated using the Unified Parkinson 's Disease Rating Scale-III ( UPDRS-III ) , the NMS Scale ( NMSS ) and the @-Item Parkinson 's Disease Questionnaire ( PDQ-@ ) .", "sentence_id": 6}
+{"abstract_id": "24289887", "label": "methods", "text": "-LSB- ( @ ) F -RSB- N - ( @-fluoropropyl ) -@ - carbon ethoxy-@ - ( @-iodophenyl ) nortropane ( FP-CIT ) photon emission tomography ( PET ) scanning was performed on each participant at baseline and again after @ months .", "sentence_id": 7}
+{"abstract_id": "24289887", "label": "results", "text": "The rhEPO administration significantly improved the NMSS and PDQ-@ scores at @ months .", "sentence_id": 8}
+{"abstract_id": "24289887", "label": "results", "text": "The UPDRS-III , which reflects motor function , did not change significantly after the rhEPO treatment .", "sentence_id": 9}
+{"abstract_id": "24289887", "label": "results", "text": "With the NMSS , the domains of cardiovascular autonomic function , sleep/fatigue , mood/cognition and attention/memory showed significant changes .", "sentence_id": 10}
+{"abstract_id": "24289887", "label": "results", "text": "None of the participants experienced any serious adverse effects .", "sentence_id": 11}
+{"abstract_id": "24289887", "label": "conclusions", "text": "We found that rhEPO had beneficial effects on NMS but not on motor function .", "sentence_id": 12}
+{"abstract_id": "24289887", "label": "conclusions", "text": "Dopaminergic refractory NMS , such as cardiovascular autonomic dysfunction and cognition , showed improvement after the administration of rhEPO .", "sentence_id": 13}
+{"abstract_id": "24289887", "label": "conclusions", "text": "Our results suggest that rhEPO might be a good candidate for the treatment of NMS in PD patients .", "sentence_id": 14}
+{"abstract_id": "24325386", "label": "objective", "text": "In the present study , the potential benefits of oral carnitine in preventing antituberculosis drug-induced hepatotoxicity ( ATDH ) were evaluated .", "sentence_id": 0}
+{"abstract_id": "24325386", "label": "methods", "text": "Fifty-four patients in the carnitine and @ patients in the placebo group completed the study .", "sentence_id": 1}
+{"abstract_id": "24325386", "label": "methods", "text": "The carnitine group received @mg oral carnitine solution twice daily for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24325386", "label": "methods", "text": "The placebo group received @mL of oral placebo solution twice daily for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24325386", "label": "methods", "text": "ATDH was defined as an increase in the serum level of aspartate aminotransferase or alanine aminotransferase greater than three or five times of the upper limit of normal with or without clinical symptoms of hepatotoxicity , respectively .", "sentence_id": 4}
+{"abstract_id": "24325386", "label": "results", "text": "During the study period , @ ( @ % ) patients experienced ATDH .", "sentence_id": 5}
+{"abstract_id": "24325386", "label": "results", "text": "Among these patients , nine ( @ % ) and @ ( @ % ) were in the carnitine and placebo groups , respectively ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24325386", "label": "results", "text": "Based on multivariate logistic regression model , age over @ years old ( odds ratio -LSB- OR -RSB- = @ , P = @ ) , human immunodeficiency virus infection ( OR = @ , P < @ ) , diabetes mellitus ( OR = @ , P = @ ) , and placebo treatment ( OR = @ , P = @ ) were identified as predisposing factors for ATDH .", "sentence_id": 7}
+{"abstract_id": "24325386", "label": "conclusions", "text": "Results of our preliminary clinical trial suggested that cotreatment with @mg oral L-carnitine solution daily for @ weeks significantly decreased the rate of ATDH .", "sentence_id": 8}
+{"abstract_id": "24468797", "label": "objective", "text": "Girdles and abdominal binders may reduce pain and stabilize the abdominal wall after laparotomy , but a risk for increased intra-abdominal pressure and decreased lung function is also hypothesized .", "sentence_id": 0}
+{"abstract_id": "24468797", "label": "objective", "text": "The aim of this study was to investigate the effect of an abdominal girdle after midline laparotomy in a randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24468797", "label": "methods", "text": "Twenty-three patients undergoing laparotomy were randomized to wear an elastic girdle postoperatively and @ were randomized to no girdle .", "sentence_id": 2}
+{"abstract_id": "24468797", "label": "methods", "text": "Pulmonary function was evaluated with ; forced vital capacity ( FVC ) , forced expiratory volume during one second ( FEV@ ) , peak expiratory flow ( PEF ) , and cough PEF .", "sentence_id": 3}
+{"abstract_id": "24468797", "label": "methods", "text": "Pain was recorded using a visual analog scale ( VAS ) .", "sentence_id": 4}
+{"abstract_id": "24468797", "label": "methods", "text": "All patients completed the ventral hernia pain questionnaire ( VHPQ ) before surgery and at the end of the study .", "sentence_id": 5}
+{"abstract_id": "24468797", "label": "methods", "text": "Intra-abdominal pressure was measured via an indwelling urinary catheter .", "sentence_id": 6}
+{"abstract_id": "24468797", "label": "methods", "text": "Wound healing was assessed from photographs .", "sentence_id": 7}
+{"abstract_id": "24468797", "label": "results", "text": "FVC , FEV@ , PEF , and cough PEF were reduced by about @ % after surgery , but there were no differences between patients with or without a girdle ( ANOVA ) .", "sentence_id": 8}
+{"abstract_id": "24468797", "label": "results", "text": "Intra-abdominal pressure and wound healing were the same in both groups .", "sentence_id": 9}
+{"abstract_id": "24468797", "label": "results", "text": "Pain was significantly lower on day @ in the girdle group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24468797", "label": "conclusions", "text": "An individually fitted elastic girdle used after midline laparotomy was found to be safe , as this did not affect lung function , coughing , intra-abdominal pressure , or wound healing .", "sentence_id": 11}
+{"abstract_id": "24468797", "label": "conclusions", "text": "The immediate decline in lung function after surgery is restrictive and due to anesthesia and the surgical procedure .", "sentence_id": 12}
+{"abstract_id": "24468797", "label": "conclusions", "text": "Pain was significantly decreased in the girdle group .", "sentence_id": 13}
+{"abstract_id": "24468797", "label": "conclusions", "text": "The study is registered at ClinicalTrials.gov , number NCT@ .", "sentence_id": 14}
+{"abstract_id": "24694337", "label": "background", "text": "Sexual dimorphism in plasma triglyceride ( TG ) metabolism is well established but it is unclear to what extent it is driven by differences in the sex hormone milieu .", "sentence_id": 0}
+{"abstract_id": "24694337", "label": "background", "text": "RESULTS from previous studies evaluating the effects of sex steroids on plasma TG homeostasis are inconclusive because they relied on orally administered synthetic hormone preparations or evaluated only plasma lipid concentrations but not kinetics .", "sentence_id": 1}
+{"abstract_id": "24694337", "label": "objective", "text": "The purpose of this study was to evaluate the effects of systemically delivered @-estradiol , progesterone , and T on very low density lipoprotein-triglyceride ( VLDL-TG ) concentration and kinetics in postmenopausal women .", "sentence_id": 2}
+{"abstract_id": "24694337", "label": "methods", "text": "VLDL-TG concentration and kinetics were evaluated by using stable isotope-labeled tracer techniques in four groups of postmenopausal women ( n = @ total ) who were studied before and after treatment with either @-estradiol ( @ mg/d via continuous delivery skin patch ) , progesterone ( @ mg/d via vaginal insert ) and T ( @ mg/d via skin gel ) , or no intervention ( control group ) .", "sentence_id": 3}
+{"abstract_id": "24694337", "label": "results", "text": "VLDL-TG concentration and kinetics were unchanged in the control group and not altered by T and progesterone administration .", "sentence_id": 4}
+{"abstract_id": "24694337", "label": "results", "text": "Estradiol treatment , in contrast , reduced VLDL-TG concentration by approximately @ % due to accelerated VLDL-TG plasma clearance ( @ @ vs. @ @ mL/min ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24694337", "label": "conclusions", "text": "Estradiol , but not progesterone or T , is a major regulator of VLDL-TG metabolism .", "sentence_id": 6}
+{"abstract_id": "25864104", "label": "background", "text": "Ombrabulin ( AVE@ ) disrupts the vasculature of established tumours and has shown preclinical synergistic anti-tumour activity when combined with cisplatin .", "sentence_id": 0}
+{"abstract_id": "25864104", "label": "background", "text": "In this phase @ trial , we aimed to assess the efficacy and safety of ombrabulin plus cisplatin compared with placebo plus cisplatin in patients with advanced soft-tissue sarcomas .", "sentence_id": 1}
+{"abstract_id": "25864104", "label": "methods", "text": "We did this multinational , randomised , double-blind , placebo-controlled phase @ study at @ centres in ten countries .", "sentence_id": 2}
+{"abstract_id": "25864104", "label": "methods", "text": "Patients aged @ years and older with metastatic soft-tissue sarcomas , an Eastern Cooperative Oncology Group performance status of @-@ , and who had previously received treatment with anthracycline and ifosfamide were randomly assigned ( @:@ ) to intravenous infusion of ombrabulin @ mg/m ( @ ) plus cisplatin @ mg/m ( @ ) or intravenous infusion of placebo plus cisplatin @ mg/m ( @ ) every @ weeks .", "sentence_id": 3}
+{"abstract_id": "25864104", "label": "methods", "text": "Patients were allocated to treatment using a permuted blocks randomisation scheme ( block size of four ) via an interactive voice-response system , and stratified by histological subtype .", "sentence_id": 4}
+{"abstract_id": "25864104", "label": "methods", "text": "Patients , medical staff , study investigators , and individuals who handled and analysed the data were masked to treatment assignment .", "sentence_id": 5}
+{"abstract_id": "25864104", "label": "methods", "text": "Our primary endpoint was median progression-free survival in the intention-to-treat population .", "sentence_id": 6}
+{"abstract_id": "25864104", "label": "methods", "text": "Safety analyses were done on all randomised patients who received at least one dose of study drug .", "sentence_id": 7}
+{"abstract_id": "25864104", "label": "methods", "text": "This trial is now closed , and is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "25864104", "label": "results", "text": "Between June @ , @ , and April @ , @ , we randomly assigned @ patients to ombrabulin plus cisplatin ( n = @ ) or placebo plus cisplatin ( n = @ ) .", "sentence_id": 9}
+{"abstract_id": "25864104", "label": "results", "text": "Median duration of follow-up was @ ( IQR @-@ ) in the placebo group and @ months ( @-@ ) in the ombrabulin group .", "sentence_id": 10}
+{"abstract_id": "25864104", "label": "results", "text": "Progression-free survival was slightly , but significantly , improved in the ombrabulin group compared with the placebo group ( median @ months -LSB- @ % CI @-@ -RSB- vs @ -LSB- @-@ -RSB- months ; hazard ratio @ -LSB- @ % CI @-@ -RSB- ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25864104", "label": "results", "text": "Grade @ or @ adverse events occurred more frequently in individuals in the ombrabulin group than in those in the placebo group and included neutropenia ( @ -LSB- @ % -RSB- in the ombrabulin group vs @ -LSB- @ % -RSB- in the placebo group ) and thrombocytopenia ( @ -LSB- @ % -RSB- vs six -LSB- @ % -RSB- for placebo ) .", "sentence_id": 12}
+{"abstract_id": "25864104", "label": "results", "text": "Adverse events leading to death occurred in @ patients in the ombrabulin group and @ patients in the placebo group .", "sentence_id": 13}
+{"abstract_id": "25864104", "label": "conclusions", "text": "The combination of ombrabulin and cisplatin significantly improved progression-free survival ; however , it did not show a sufficient clinical benefit in patients with advanced soft-tissue sarcomas to support its use as a therapeutic option .", "sentence_id": 14}
+{"abstract_id": "25864104", "label": "conclusions", "text": "Predictive biomarkers are needed for the rational clinical development of tumour vascular-disrupting drugs for soft-tissue sarcomas .", "sentence_id": 15}
+{"abstract_id": "24660579", "label": "objective", "text": "To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replace Western Medicine .", "sentence_id": 0}
+{"abstract_id": "24660579", "label": "methods", "text": "The participants in this multi-center , randomized , and controlled study were randomly divided into two groups : group A ( n = @ ) , treated with heat-sensitive moxibustion ( @ sessions ) and group B ( n = @ ) , treated with Seretide ( salmeterol @ plg/fluticasone @ pg , twice a day ) .", "sentence_id": 1}
+{"abstract_id": "24660579", "label": "methods", "text": "The scores of asthma control test ( ACT ) , forced expiratory volume in @ second ( FEV@ ) , peak expiratory flow ( PEF ) , and attack frequency were measured after @ , @ , @ , and @ days of treatment .", "sentence_id": 2}
+{"abstract_id": "24660579", "label": "methods", "text": "Patients followed up @ and @ months after treatment .", "sentence_id": 3}
+{"abstract_id": "24660579", "label": "results", "text": "There was a significant difference ( P = @ ) in the ACT score and lung function between the two groups after @ months of treatment and ( P = @ @ ) during the follow-up visits .", "sentence_id": 4}
+{"abstract_id": "24660579", "label": "results", "text": "In addition , heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the @-month follow-up visit .", "sentence_id": 5}
+{"abstract_id": "24660579", "label": "conclusions", "text": "This study shows that heat-sensitive moxibustion may have a comparable curative effect to Seretide ( salmetero/fluticasone ) on asthma .", "sentence_id": 6}
+{"abstract_id": "24295530", "label": "objective", "text": "To determine the efficacy of a custom-made wheelchair simulation in training children to use a powered wheelchair ( PWC ) .", "sentence_id": 0}
+{"abstract_id": "24295530", "label": "methods", "text": "Randomized controlled trial employing the @C/ID-model of learning .", "sentence_id": 1}
+{"abstract_id": "24295530", "label": "methods", "text": "Twenty-eight typically developing children ( @M , @F ; mean age @ years , SD @ months ) were assessed on their operation of a PWC using a functional evaluation rating scale .", "sentence_id": 2}
+{"abstract_id": "24295530", "label": "methods", "text": "Participants were randomly assigned to intervention ( @ @-minute training sessions using a joystick operated wheelchair simulation ) or control conditions ( no task ) , and were reassessed on their PWC use after the intervention phase .", "sentence_id": 3}
+{"abstract_id": "24295530", "label": "methods", "text": "Additional data from the simulation on completion times , errors , and total scores were recorded for the intervention group .", "sentence_id": 4}
+{"abstract_id": "24295530", "label": "results", "text": "Analysis of variance showed a main effect of time , with planned comparisons revealing a statistically significant change in PWC use for the intervention ( p = @ ) but not the control condition .", "sentence_id": 5}
+{"abstract_id": "24295530", "label": "results", "text": "Although the intervention group showed greater improvement than the controls , this did not reach statistical significance .", "sentence_id": 6}
+{"abstract_id": "24295530", "label": "results", "text": "Multiple regression analyses showed that gender was predictive of pretest ( p = @ ) functional ability .", "sentence_id": 7}
+{"abstract_id": "24295530", "label": "conclusions", "text": "A simulated wheelchair task appears to be effective in helping children learn to operate a PWC .", "sentence_id": 8}
+{"abstract_id": "24295530", "label": "conclusions", "text": "Greater attention should be given to female learners who underperformed when compared with their male counterparts .", "sentence_id": 9}
+{"abstract_id": "24295530", "label": "conclusions", "text": "This low-cost intervention could be easily used at home to reduce PWC training times in children with motor disorders .", "sentence_id": 10}
+{"abstract_id": "24253956", "label": "background", "text": "Aim of the study was to compare the chosen position of polyaxial locking screws with the position of monoaxial screws in the humeral head of proximal humeral fractures treated by locked plating .", "sentence_id": 0}
+{"abstract_id": "24253956", "label": "methods", "text": "In a prospective randomized observational study , @ consecutive patients ( mean age @ years ) sustaining a displaced proximal humeral fracture were treated with either monoaxial or polyaxial screw-inserted locking plate fixation .", "sentence_id": 1}
+{"abstract_id": "24253956", "label": "methods", "text": "The chosen positions of locking screws were identified from standardized postoperative radiographs in anteroposterior and outlet-view , with regard to a regional mapping of the humeral head .", "sentence_id": 2}
+{"abstract_id": "24253956", "label": "results", "text": "In monoaxial locking technique , a mean of @ screws purchased the humeral head ( @ % CI @-@ @ ) , and in polyaxial locking technique , a mean of @ screws ( @ % CI @-@ @ ) , respectively .", "sentence_id": 3}
+{"abstract_id": "24253956", "label": "results", "text": "Screws were placed in the regions superolateral : monoaxial @ % , polyaxial @ % ( p = @ ) ; superomedial : monoaxial @ % , polyaxial @ % ( p = @ ) ; inferolateral : monoaxial @ % , polyaxial @ % ( p = @ ) ; inferomedial : monoaxial @ % , polyaxial @ % ( p = @ ) , superoposterior : monoaxial @ % , polyaxial @ % ( p = @ ) ; superoanterior : monoaxial @ % , polyaxial @ % ( p = @ ) ; inferoposterior : monoaxial @ % , polyaxial @ % ( p = @ ) and inferoanterior : monoaxial @ % , polyaxial : @ % ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24253956", "label": "conclusions", "text": "The chosen screws ' position in monoaxial and polyaxial locking plate fixation of displaced proximal humeral fractures do not differ significantly .", "sentence_id": 5}
+{"abstract_id": "24253956", "label": "conclusions", "text": "However , loss of fixation is observed more frequently if the fixation did not include at least one screw within the superoposterior region of the humeral head , suggesting that a screw purchasing the superoposterior region is beneficial in locked plating of proximal humeral fractures .", "sentence_id": 6}
+{"abstract_id": "24253956", "label": "methods", "text": "Treatment Study , Level II .", "sentence_id": 7}
+{"abstract_id": "25122979", "label": "objective", "text": "To evaluate the efficacy of a marketed oscillating-rotating ( O-R ) power toothbrush ( Oral-B Triumph with SmartGuide and FlossAction brush head , D@/EB@ ) to a new sonic toothbrush ( Sonicare FlexCare Platinum ) in the reduction of gingivitis and plaque over a @-week test period .", "sentence_id": 0}
+{"abstract_id": "25122979", "label": "methods", "text": "This was a single center , randomized , open label , examiner-blind , two-treatment , parallel group study .", "sentence_id": 1}
+{"abstract_id": "25122979", "label": "methods", "text": "Subjects who met the entrance criteria were enrolled in the study and randomly assigned to either the O-R or sonic treatment group .", "sentence_id": 2}
+{"abstract_id": "25122979", "label": "methods", "text": "Subjects brushed with their assigned toothbrush and a marketed fluoride dentifrice for two minutes twice daily at home for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25122979", "label": "methods", "text": "Gingivitis and plaque were evaluated at Baseline , Week @ , and Week @ .", "sentence_id": 4}
+{"abstract_id": "25122979", "label": "methods", "text": "Gingivitis was assessed using the Modified Gingival Index ( MGI ) and Gingival Bleeding Index ( GBI ) , and plaque was assessed using the Rustogi Modified Navy Plaque Index ( RMNPI ) .", "sentence_id": 5}
+{"abstract_id": "25122979", "label": "methods", "text": "Data were analyzed using an Analysis of Covariance ( ANCOVA ) with Baseline as the covariate .", "sentence_id": 6}
+{"abstract_id": "25122979", "label": "results", "text": "In total , @ subjects ( @ per group ) were randomized to treatment and @ subjects completed the study .", "sentence_id": 7}
+{"abstract_id": "25122979", "label": "results", "text": "Both brushes produced statistically significant ( p < @ ) reductions in gingivitis and plaque measures relative to Baseline .", "sentence_id": 8}
+{"abstract_id": "25122979", "label": "results", "text": "At Week @ , the O-R brush demonstrated significantly greater reductions than the sonic brush in whole mouth gingivitis measures ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25122979", "label": "results", "text": "Additionally , the O-R brush presented significantly fewer bleeding sites ( p < @ ) and significantly greater reductions in whole mouth plaque measures ( p < or = @ ) at Weeks @ and @ versus the sonic brush .", "sentence_id": 10}
+{"abstract_id": "25122979", "label": "results", "text": "The benefit for the O-R brush versus the sonic brush at Week @ was @ % for gingivitis , @ % for number of bleeding sites , and @ % for whole mouth plaque .", "sentence_id": 11}
+{"abstract_id": "25122979", "label": "results", "text": "There were no adverse events reported or observed for either brush .", "sentence_id": 12}
+{"abstract_id": "25122979", "label": "conclusions", "text": "The oscillating-rotating toothbrush demonstrated statistically significantly greater reductions in whole mouth plaque at Weeks @ and @ , as well as significantly greater gingivitis reductions over the long-term ( @ weeks ) , compared to the new sonic toothbrush .", "sentence_id": 13}
+{"abstract_id": "24702629", "label": "background", "text": "The echocardiographic substudy of the OASIS-@ trial evaluated the prognostic implications of left ventricle ( LV ) systolic and diastolic dysfunction early postacute ST-segment elevation myocardial infarction ( STEMI ) in patients treated with fondaparinux versus usual care .", "sentence_id": 0}
+{"abstract_id": "24702629", "label": "methods", "text": "Comprehensive echocardiograms were performed a median of @ days after the index STEMI in @ patients , @ randomized to fondaparinux and @ to usual care ( unfractionated heparin or placebo ) , to assess LV systolic and diastolic function , LV mass , and LV end-systolic and end-diastolic volumes .", "sentence_id": 1}
+{"abstract_id": "24702629", "label": "methods", "text": "A total of @ ( @ % ) patients were followed up for @ months and @ ( @ % ) for @ months .", "sentence_id": 2}
+{"abstract_id": "24702629", "label": "methods", "text": "Major cardiac events ( MACE ) were defined as the composite of death , reinfarction , heart failure , or cardiogenic shock and resuscitated cardiac arrest .", "sentence_id": 3}
+{"abstract_id": "24702629", "label": "results", "text": "Patients with LV ejection fraction ( LVEF ) @ % and restrictive diastolic function ( RDF ) were at greatly increased risk of MACE ( hazard ratio -LSB- HR -RSB- = @ , @ % CI , @ ) compared to patients with LVEF @ % and without RDF .", "sentence_id": 4}
+{"abstract_id": "24702629", "label": "results", "text": "RDF remained a strong predictor for MACE in patients with LVEF @ % ( HR = @ , @ % CI , @ ) and in multivariate models adjusted for LVEF , LV end-systolic volume , and clinical variables .", "sentence_id": 5}
+{"abstract_id": "24702629", "label": "conclusions", "text": "In this large international trial , LV systolic and diastolic function , as determined by echocardiography early following STEMI , are incremental predictors of MACE .", "sentence_id": 6}
+{"abstract_id": "24702629", "label": "conclusions", "text": "In addition , RDF is a strong independent predictor of MACE after STEMI across a broad range of LVEF .", "sentence_id": 7}
+{"abstract_id": "24906419", "label": "background", "text": "The self-reported health and functional status of persons with back pain in the United States have declined in recent years , despite greatly increased medical expenditures due to this problem .", "sentence_id": 0}
+{"abstract_id": "24906419", "label": "background", "text": "Although patient psychosocial factors such as pain-related beliefs , thoughts and coping behaviors have been demonstrated to affect how well patients respond to treatments for back pain , few patients receive treatments that address these factors .", "sentence_id": 1}
+{"abstract_id": "24906419", "label": "background", "text": "Cognitive-behavioral therapy ( CBT ) , which addresses psychosocial factors , has been found to be effective for back pain , but access to qualified therapists is limited .", "sentence_id": 2}
+{"abstract_id": "24906419", "label": "background", "text": "Another treatment option with potential for addressing psychosocial issues , mindfulness-based stress reduction ( MBSR ) , is increasingly available .", "sentence_id": 3}
+{"abstract_id": "24906419", "label": "background", "text": "MBSR has been found to be helpful for various mental and physical conditions , but it has not been well-studied for application with chronic back pain patients .", "sentence_id": 4}
+{"abstract_id": "24906419", "label": "background", "text": "In this trial , we will seek to determine whether MBSR is an effective and cost-effective treatment option for persons with chronic back pain , compare its effectiveness and cost-effectiveness compared with CBT and explore the psychosocial variables that may mediate the effects of MBSR and CBT on patient outcomes .", "sentence_id": 5}
+{"abstract_id": "24906419", "label": "methods", "text": "In this trial , we will randomize @ adults with nonspecific chronic back pain to CBT , MBSR or usual care arms ( @ per group ) .", "sentence_id": 6}
+{"abstract_id": "24906419", "label": "methods", "text": "Both interventions will consist of eight weekly @-hour group sessions supplemented by home practice .", "sentence_id": 7}
+{"abstract_id": "24906419", "label": "methods", "text": "The MBSR protocol also includes an optional @-hour retreat .", "sentence_id": 8}
+{"abstract_id": "24906419", "label": "methods", "text": "Interviewers masked to treatment assignments will assess outcomes @ , @ , @ and @weeks postrandomization .", "sentence_id": 9}
+{"abstract_id": "24906419", "label": "methods", "text": "The primary outcomes will be pain-related functional limitations ( based on the Roland Disability Questionnaire ) and symptom bothersomeness ( rated on a @ to @ numerical rating scale ) at @weeks .", "sentence_id": 10}
+{"abstract_id": "24906419", "label": "conclusions", "text": "If MBSR is found to be an effective and cost-effective treatment option for patients with chronic back pain , it will become a valuable addition to the limited treatment options available to patients with significant psychosocial contributors to their pain .", "sentence_id": 11}
+{"abstract_id": "24953208", "label": "background", "text": "Endoplasmic reticulum stress and unfolded protein response have been recently associated with the development of inflammatory bowel diseases in adults .", "sentence_id": 0}
+{"abstract_id": "24953208", "label": "background", "text": "We aimed at assessing the involvement of these pathways also in paediatric inflammatory bowel disease by analysing the expression of the main genes involved in endoplasmic reticulum stress and correlating them with the degree of intestinal inflammation .", "sentence_id": 1}
+{"abstract_id": "24953208", "label": "methods", "text": "Real-time PCR and Western blot analysis of the expression of the endoplasmic reticulum stress marker HSPA@ and of selected genes representing the three pathways of unfolded protein response ( IRE-XBP@ , PERK-ATF@ , ATF@p@-p@ ) in inflamed and uninflamed biopsies from @ inflammatory bowel disease paediatric patients and @ controls .", "sentence_id": 2}
+{"abstract_id": "24953208", "label": "results", "text": "HSPA@ , PDIA@ , as well as unspliced and spliced XBP@ mRNAs were significantly increased in patients ' inflamed colonic mucosa compared to uninflamed mucosa and controls .", "sentence_id": 3}
+{"abstract_id": "24953208", "label": "results", "text": "HSPA@ , PDIA@ , ATF@ , and phospho-IRE proteins were also upregulated , indicating the activation of the IRE-XBP@ and ATF@p@-p@ branches of unfolded protein response .", "sentence_id": 4}
+{"abstract_id": "24953208", "label": "results", "text": "A positive significant correlation between interleukin-@ levels , as a marker of inflammation , and upregulated genes was found in the inflamed colonic mucosa .", "sentence_id": 5}
+{"abstract_id": "24953208", "label": "conclusions", "text": "A deregulation of the genes involved in the endoplasmic reticulum stress and unfolded protein response pathways may be a key component of the inflammatory response in paediatric patients with inflammatory bowel disease .", "sentence_id": 6}
+{"abstract_id": "25910800", "label": "background", "text": "The aims of the present study were to define the prevalence of untreated atrial fibrillation ( AF ) in a systematic screening program using intermittent ECG recordings among @ - to @-year-old individuals and to study the feasibility of initiating protective oral anticoagulant ( OAC ) treatment .", "sentence_id": 0}
+{"abstract_id": "25910800", "label": "results", "text": "Half of the @ - to @-year-old population in @ Swedish regions were invited to a screening program for AF .", "sentence_id": 1}
+{"abstract_id": "25910800", "label": "results", "text": "Participants without a previous diagnosis of AF underwent intermittent ECG recordings over @ weeks .", "sentence_id": 2}
+{"abstract_id": "25910800", "label": "results", "text": "If AF was detected , participants were offered OAC .", "sentence_id": 3}
+{"abstract_id": "25910800", "label": "results", "text": "During the @-month inclusion period , @ inhabitants were invited .", "sentence_id": 4}
+{"abstract_id": "25910800", "label": "results", "text": "Of these , @ ( @ % ) participated .", "sentence_id": 5}
+{"abstract_id": "25910800", "label": "results", "text": "Of the participants , @ ( @ % ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) were found to have previously unknown AF , and of these , AF was found in @ ( @ % of the screened population ) on their first ECG .", "sentence_id": 6}
+{"abstract_id": "25910800", "label": "results", "text": "The use of intermittent ECGs increased new AF detection @-fold .", "sentence_id": 7}
+{"abstract_id": "25910800", "label": "results", "text": "A previous diagnosis of AF was known in @ % ( n = @ ; @ % CI , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25910800", "label": "results", "text": "Total AF prevalence in the screened population was @ % .", "sentence_id": 9}
+{"abstract_id": "25910800", "label": "results", "text": "Of participants with known AF , @ ( @ % ; @ % CI , @-@ @ ) had no OAC treatment .", "sentence_id": 10}
+{"abstract_id": "25910800", "label": "results", "text": "In total , @ % ( @ % CI , @-@ @ ) of the screened population had untreated AF ; screening resulted in initiation of OAC treatment in @ % ( @ % CI , @-@ @ ) of the screened population .", "sentence_id": 11}
+{"abstract_id": "25910800", "label": "results", "text": "More than @ % of the participants with previously undiagnosed AF accepted initiation of OAC treatment .", "sentence_id": 12}
+{"abstract_id": "25910800", "label": "conclusions", "text": "Mass screening for AF in a @ - to @-year-old population identifies a significant proportion of participants with untreated AF .", "sentence_id": 13}
+{"abstract_id": "25910800", "label": "conclusions", "text": "Initiation of stroke prophylactic treatment was highly successful in individuals with newly diagnosed AF .", "sentence_id": 14}
+{"abstract_id": "25605838", "label": "objective", "text": "CEREBEL compared the incidence of CNS metastases as first site of relapse in patients with human epidermal growth factor receptor @-positive metastatic breast cancer receiving lapatinib-capecitabine or trastuzumab-capecitabine .", "sentence_id": 0}
+{"abstract_id": "25605838", "label": "methods", "text": "Patients without baseline CNS metastases were randomly assigned ( @:@ ) to receive lapatinib-capecitabine ( lapatinib @,@ mg per day ; capecitabine @,@ mg/m ( @ ) per day on days @ to @ every @ days ) or trastuzumab-capecitabine ( trastuzumab loading dose of @ mg/kg followed by an infusion of @ mg/kg every @ weeks ; capecitabine @,@ mg/m ( @ ) per day on days @ to @ every @ days ) .", "sentence_id": 1}
+{"abstract_id": "25605838", "label": "methods", "text": "The primary end point was incidence of CNS metastases as first site of relapse .", "sentence_id": 2}
+{"abstract_id": "25605838", "label": "methods", "text": "Secondary end points included progression-free survival ( PFS ) and overall survival ( OS ) .", "sentence_id": 3}
+{"abstract_id": "25605838", "label": "results", "text": "The study was terminated early with @ enrolled patients ( @ received lapatinib-capecitabine , and @ received trastuzumab-capecitabine ) .", "sentence_id": 4}
+{"abstract_id": "25605838", "label": "results", "text": "Incidence of CNS metastases as first site of relapse was @ % ( eight of @ patients ) for lapatinib-capecitabine and @ % ( @ of @ patients ) for trastuzumab-capecitabine ( treatment differences , -@ % ; @ % CI , -@ % to @ % ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25605838", "label": "results", "text": "PFS and OS were longer with trastuzumab-capecitabine versus lapatinib-capecitabine ( hazard ratio -LSB- HR -RSB- for PFS , @ ; @ % CI , @ to @ ; HR for OS , @ ; @ % CI , @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25605838", "label": "results", "text": "Serious adverse events were reported in @ % ( @ of @ patients ) and @ % ( @ of @ patients ) of patients in the lapatinib-capecitabine and trastuzumab-capecitabine arms , respectively .", "sentence_id": 7}
+{"abstract_id": "25605838", "label": "conclusions", "text": "CEREBEL is inconclusive for the primary end point , and no difference was detected between lapatinb-capecitabine and trastuzumab-capecitabine for the incidence of CNS metastases .", "sentence_id": 8}
+{"abstract_id": "25605838", "label": "conclusions", "text": "A better outcome was observed with trastuzumab-capecitabine in the overall population .", "sentence_id": 9}
+{"abstract_id": "25605838", "label": "conclusions", "text": "However , lapatinib-capecitabine efficacy may have been affected by previous exposure to a trastuzumab regimen and/or when treatment was given as first - or second-line therapy in the metastatic setting .", "sentence_id": 10}
+{"abstract_id": "24553304", "label": "objective", "text": "Factors underlying differential responsiveness to opioid analgesic medications used in chronic pain management are poorly understood .", "sentence_id": 0}
+{"abstract_id": "24553304", "label": "objective", "text": "We tested whether individual differences in endogenous opioid inhibition of chronic low-back pain were associated with the magnitude of acute reductions in back pain ratings after morphine administration .", "sentence_id": 1}
+{"abstract_id": "24553304", "label": "methods", "text": "In randomized counterbalanced order over three sessions , @ chronic low-back pain patients received intravenous naloxone ( @ mg ) , morphine ( @ mg/kg ) , or placebo .", "sentence_id": 2}
+{"abstract_id": "24553304", "label": "methods", "text": "Back pain intensity was rated predrug and again after peak drug activity was achieved using the McGill Pain Questionnaire-Short Form ( Sensory and Affective subscales , VAS Intensity measure ) .", "sentence_id": 3}
+{"abstract_id": "24553304", "label": "methods", "text": "Opioid blockade effect measures to index degree of endogenous opioid inhibition of back pain intensity were derived as the difference between predrug to postdrug changes in pain intensity across placebo and naloxone conditions , with similar morphine responsiveness measures derived across placebo and morphine conditions .", "sentence_id": 4}
+{"abstract_id": "24553304", "label": "results", "text": "Morphine significantly reduced back pain compared with placebo ( McGill Pain Questionnaire-Short Form Sensory , VAS ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24553304", "label": "results", "text": "There were no overall effects of opioid blockade on back pain intensity .", "sentence_id": 6}
+{"abstract_id": "24553304", "label": "results", "text": "However , individual differences in opioid blockade effects were significantly associated with the degree of acute morphine-related reductions in back pain on all measures , even after controlling for effects of age , sex , and chronic pain duration ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24553304", "label": "results", "text": "Individuals exhibiting greater endogenous opioid inhibition of chronic back pain intensity reported less acute relief of back pain with morphine .", "sentence_id": 8}
+{"abstract_id": "24553304", "label": "conclusions", "text": "Morphine appears to provide better acute relief of chronic back pain in individuals with lower natural opioidergic inhibition of chronic pain intensity .", "sentence_id": 9}
+{"abstract_id": "24553304", "label": "conclusions", "text": "Possible implications for personalized medicine are discussed .", "sentence_id": 10}
+{"abstract_id": "25615542", "label": "objective", "text": "The purpose of this study was to examine a dynamic assessment with graduated prompts to assess morphological awareness and determine whether such a task was related to third-grade literacy success .", "sentence_id": 0}
+{"abstract_id": "25615542", "label": "methods", "text": "A dynamic assessment of morphological awareness was adapted and administered to @ third-grade students in addition to a norm-referenced language and literacy battery .", "sentence_id": 1}
+{"abstract_id": "25615542", "label": "results", "text": "A dynamic assessment of morphological awareness measured a range of performance including that of emerging morphological awareness abilities and provided rich linguistic insights for how best to scaffold and prompt for such a skill .", "sentence_id": 2}
+{"abstract_id": "25615542", "label": "results", "text": "In addition , the dynamic morphological awareness measure was found to be significantly related to , and to contribute unique variance to , reading comprehension abilities .", "sentence_id": 3}
+{"abstract_id": "25615542", "label": "conclusions", "text": "These results suggest that morphological awareness is an important factor to consider when addressing students ' literacy performance in early elementary school and that dynamic assessment appears to be a clinically valuable tool when examining early morphological awareness abilities .", "sentence_id": 4}
+{"abstract_id": "24835379", "label": "background", "text": "Esophagogastrostomy for oesophageal cancer is the standard surgical treatment .", "sentence_id": 0}
+{"abstract_id": "24835379", "label": "background", "text": "However , traditional techniques have been associated with high frequency of anastomotic complications .", "sentence_id": 1}
+{"abstract_id": "24835379", "label": "background", "text": "The purpose of this study is to clarify the superiority of the oesophageal flap valvuloplasty and wrapping suturing technique in preventing postoperative complications after oesophagectomy for oesophageal cancer .", "sentence_id": 2}
+{"abstract_id": "24835379", "label": "methods", "text": "A prospective , randomised study was performed on @ patients treated for esophageal cancer between January @ and December @ .", "sentence_id": 3}
+{"abstract_id": "24835379", "label": "methods", "text": "The trial registry number is ChiCTR-TRC-@ in the Chinese Clinical Trial Registry .", "sentence_id": 4}
+{"abstract_id": "24835379", "label": "results", "text": "Anastomotic leaks occurred in four patients in group A ( @ % ) and in twelve patients in group B ( @ % ) with statistically significant ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24835379", "label": "results", "text": "During the evaluation of benign stricture seven patients were excluded for hospital mortality .", "sentence_id": 6}
+{"abstract_id": "24835379", "label": "results", "text": "Thirty three patients in group A ( @ % ) and @ patients in group B ( @ % ) occurred anastomotic stricture respectively ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24835379", "label": "results", "text": "Furthermore , reflux oesophagitis and Barrett 's epithelium were found in @ patients ( @ % ) of group B , and @ ( @ % ) patients in group A ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24835379", "label": "conclusions", "text": "The oesophageal flap valvuloplasty and wrapping suturing technique decreased anastomotic leakage incidence and stricture rate thereby decreasing the morbidity and mortality .", "sentence_id": 9}
+{"abstract_id": "24835379", "label": "conclusions", "text": "This procedure also prevented the occurrence of gastroesophageal reflux after esophagectomy .", "sentence_id": 10}
+{"abstract_id": "24789659", "label": "objective", "text": "Ultrasound-guided long-axis in-plane sciatic perineural catheter insertion has been described but not validated .", "sentence_id": 0}
+{"abstract_id": "24789659", "label": "objective", "text": "For the popliteal-sciatic nerve , we hypothesized that a long-axis in-plane technique , placing the catheter parallel and posterior to the nerve , results in faster onset of sensory anesthesia compared to a short-axis in-plane technique .", "sentence_id": 1}
+{"abstract_id": "24789659", "label": "methods", "text": "Preoperatively , patients receiving a popliteal-sciatic perineural catheter were randomly assigned to either the long-axis or short-axis technique .", "sentence_id": 2}
+{"abstract_id": "24789659", "label": "methods", "text": "Mepivacaine @ % was administered via the catheter following insertion .", "sentence_id": 3}
+{"abstract_id": "24789659", "label": "methods", "text": "The primary outcome was time to achieve complete sensory anesthesia .", "sentence_id": 4}
+{"abstract_id": "24789659", "label": "methods", "text": "Secondary outcomes included procedural time , onset time of motor block , and pain on postoperative day @ .", "sentence_id": 5}
+{"abstract_id": "24789659", "label": "results", "text": "Fifty patients were enrolled .", "sentence_id": 6}
+{"abstract_id": "24789659", "label": "results", "text": "In the long-axis group ( n = @ ) , all patients except @ ( @ % ) had successful catheter placement per protocol .", "sentence_id": 7}
+{"abstract_id": "24789659", "label": "results", "text": "Two patients ( @ % ) in the long-axis group and @ patient ( @ % ) in the short-axis group ( n = @ ) did not achieve sensory anesthesia by @ min and were withdrawn .", "sentence_id": 8}
+{"abstract_id": "24789659", "label": "results", "text": "Seventeen of @ ( @ % ) and @ of @ ( @ % ) patients in the short-axis and long-axis groups , respectively , achieved the primary outcome of complete sensory anesthesia ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24789659", "label": "results", "text": "The short-axis group ( n = @ ) required a median ( @th-@th ) of @ ( @-@ @ ) min compared to @ ( @-@ @ ) min for the long-axis group ( n = @ , p = @ ) to achieve complete sensory anesthesia .", "sentence_id": 10}
+{"abstract_id": "24789659", "label": "results", "text": "Procedural time was @ ( @-@ @ ) min for the short-axis and @ ( @-@ @ ) min for the long-axis ( p < @ ) group .", "sentence_id": 11}
+{"abstract_id": "24789659", "label": "results", "text": "There were no statistically significant differences in other secondary outcomes .", "sentence_id": 12}
+{"abstract_id": "24789659", "label": "conclusions", "text": "Long-axis in-plane popliteal-sciatic perineural catheter insertion requires more time to perform compared to a short-axis in-plane technique without demonstrating any advantages .", "sentence_id": 13}
+{"abstract_id": "25288340", "label": "objective", "text": "Although the analgesic effect of periarticular injection after total knee arthroplasty ( TKA ) has been well documented , the gold standard for drug combination has not yet been established .", "sentence_id": 0}
+{"abstract_id": "25288340", "label": "objective", "text": "In this study , the analgesic effects of six different drug combinations were compared .", "sentence_id": 1}
+{"abstract_id": "25288340", "label": "methods", "text": "A total of @ patients undergoing TKA for primary osteoarthritis were randomized into one of six groups : a control group ( saline solution , epinephrine , and cefazolin , n = @ ) , Group @ ( ropivacaine , n = @ ) , Group @ ( ropivacaine + morphine , n = @ ) , Group @ ( ropivacaine + ketorolac , n = @ ) , Group @ ( ropivacaine + morphine + ketorolac , n = @ ) , and Group @ ( ropivacaine + morphine + ketorolac + methylprednisolone , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25288340", "label": "methods", "text": "Pain level assessed by visual analogue scale ( VAS ) and opioid consumption were primary outcomes .", "sentence_id": 3}
+{"abstract_id": "25288340", "label": "methods", "text": "The incidence of complications , range of motion ( ROM ) , C-reactive protein ( CRP ) value , and the amount of post-operative blood drainage were also compared .", "sentence_id": 4}
+{"abstract_id": "25288340", "label": "results", "text": "Patients in Groups @ and @ complained less pain than the control group for the first @ h after surgery , and the patients in the other groups showed less pain only during the initial @ h after surgery .", "sentence_id": 5}
+{"abstract_id": "25288340", "label": "results", "text": "Groups @ and @ also showed less opioid consumption than the control group during the @ h period after surgery .", "sentence_id": 6}
+{"abstract_id": "25288340", "label": "results", "text": "Patients in Group @ showed no significant difference in VAS score and opioid consumption compared with Group @ , but they had lower CRP value and greater ROM than any other groups at post-operative day @ and day @ .", "sentence_id": 7}
+{"abstract_id": "25288340", "label": "conclusions", "text": "The combination of ropivacaine , morphine , and ketorolac showed a significantly stronger and sufficiently synergistic analgesic effect without adding methylprednisolone in periarticular injection after TKA .", "sentence_id": 8}
+{"abstract_id": "25288340", "label": "conclusions", "text": "The clinical relevance of the study is that the combination of ropivacaine , morphine , and ketorolac can be a good option for periarticular injection following TKA in terms of synergistic analgesic effect and efficiency of drug combination .", "sentence_id": 9}
+{"abstract_id": "25982539", "label": "background", "text": "Secukinumab has demonstrated high , sustained efficacy in psoriasis to @ weeks on a fixed-interval regimen .", "sentence_id": 0}
+{"abstract_id": "25982539", "label": "objective", "text": "We sought to compare a retreatment-as-needed versus a fixed-interval regimen .", "sentence_id": 1}
+{"abstract_id": "25982539", "label": "methods", "text": "In this double-blind study , adults with moderate to severe plaque psoriasis were randomized @:@ to subcutaneous secukinumab at @ mg ( n = @ ) or @ mg ( n = @ ) weekly from baseline until week @ , and at week @ .", "sentence_id": 2}
+{"abstract_id": "25982539", "label": "methods", "text": "At week @ , patients achieving @ % or more improvement from baseline Psoriasis Area and Severity Index score ( PASI @ ) were rerandomized to @ dose levels of secukinumab retreatment as needed ( n = @ , @ mg ; n = @ , @ mg ) or fixed interval ( n = @ ; n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25982539", "label": "methods", "text": "Primary end point was noninferiority of retreatment as needed versus fixed interval for maintaining PASI @ to week @ .", "sentence_id": 4}
+{"abstract_id": "25982539", "label": "results", "text": "Secukinumab induced high responses by week @ ( @ % -@ % PASI @ responders ) .", "sentence_id": 5}
+{"abstract_id": "25982539", "label": "results", "text": "From week @ to week @ , more patients on fixed interval ( @ % , @ mg ; @ % , @ mg ) maintained PASI @ versus retreatment as needed ( @ % ; @ % ) ; statistical noninferiority of retreatment as needed was not established .", "sentence_id": 6}
+{"abstract_id": "25982539", "label": "results", "text": "Overall safety , including very low incidences of treatment-emergent anti-drug antibodies ( < @ % ) , was similar between regimens .", "sentence_id": 7}
+{"abstract_id": "25982539", "label": "conclusions", "text": "The primary end point was developed without any known precedent .", "sentence_id": 8}
+{"abstract_id": "25982539", "label": "conclusions", "text": "Secukinumab fixed interval showed clear benefit versus the study-specified retreatment-as-needed regimen for maintaining efficacy .", "sentence_id": 9}
+{"abstract_id": "25982539", "label": "conclusions", "text": "Both regimens exhibited safety consistent with previous trials .", "sentence_id": 10}
+{"abstract_id": "25982539", "label": "conclusions", "text": "The potential of retreatment as needed with secukinumab warrants further investigation .", "sentence_id": 11}
+{"abstract_id": "25847605", "label": "objective", "text": "The purpose of this study was to quantify the frequency and clinical severity of quality deficiencies in intensity modulated radiation therapy ( IMRT ) planning in the Radiation Therapy Oncology Group @ protocol .", "sentence_id": 0}
+{"abstract_id": "25847605", "label": "methods", "text": "A total of @ IMRT patients from the high-dose arm ( @ Gy ) of RTOG @ were analyzed .", "sentence_id": 1}
+{"abstract_id": "25847605", "label": "methods", "text": "To quantify plan quality , we used established knowledge-based methods for patient-specific dose-volume histogram ( DVH ) prediction of organs at risk and a Lyman-Kutcher-Burman ( LKB ) model for grade @ rectal complications to convert DVHs into normal tissue complication probabilities ( NTCPs ) .", "sentence_id": 2}
+{"abstract_id": "25847605", "label": "methods", "text": "The LKB model was validated by fitting dose-response parameters relative to observed toxicities .", "sentence_id": 3}
+{"abstract_id": "25847605", "label": "methods", "text": "The @th percentile ( @ of @ ) of plans with the lowest excess risk ( difference between clinical and model-predicted NTCP ) were used to create a model for the presumed best practices in the protocol ( pDVH@ , top@ % ) .", "sentence_id": 4}
+{"abstract_id": "25847605", "label": "methods", "text": "Applying the resultant model to the entire sample enabled comparisons between DVHs that patients could have received to DVHs they actually received .", "sentence_id": 5}
+{"abstract_id": "25847605", "label": "methods", "text": "Excess risk quantified the clinical impact of suboptimal planning .", "sentence_id": 6}
+{"abstract_id": "25847605", "label": "methods", "text": "Accuracy of pDVH predictions was validated by replanning @ of @ patients ( @ % ) , including equal numbers of presumed `` high-quality , '' `` low-quality , '' and randomly sampled plans .", "sentence_id": 7}
+{"abstract_id": "25847605", "label": "methods", "text": "NTCP-predicted toxicities were compared to adverse events on protocol .", "sentence_id": 8}
+{"abstract_id": "25847605", "label": "results", "text": "Existing models showed that bladder-sparing variations were less prevalent than rectum quality variations and that increased rectal sparing was not correlated with target metrics ( dose received by @ % and @ % of the PTV , respectively ) .", "sentence_id": 9}
+{"abstract_id": "25847605", "label": "results", "text": "Observed toxicities were consistent with current LKB parameters .", "sentence_id": 10}
+{"abstract_id": "25847605", "label": "results", "text": "Converting DVH and pDVH@ , top@ % to rectal NTCPs , we observed @ of @ patients ( @ % ) with @ % excess risk , @ of @ patients ( @ % ) with @ % excess risk , and @ of @ patients ( @ % ) with @ % excess risk .", "sentence_id": 11}
+{"abstract_id": "25847605", "label": "results", "text": "Replanning demonstrated the predicted NTCP reductions while maintaining the volume of the PTV receiving prescription dose .", "sentence_id": 12}
+{"abstract_id": "25847605", "label": "results", "text": "An equivalent sample of high-quality plans showed fewer toxicities than low-quality plans , @ of @ versus @ of @ respectively , although these differences were not significant ( P = @ ) due to insufficient statistical power in this retrospective study .", "sentence_id": 13}
+{"abstract_id": "25847605", "label": "conclusions", "text": "Plan quality deficiencies in RTOG @ exposed patients to substantial excess risk for rectal complications .", "sentence_id": 14}
+{"abstract_id": "25475461", "label": "background", "text": "Transfer patterns , procedure rates , and outcomes of patients with non-ST-segment elevation myocardial infarction ( NSTEMI ) presenting to Canadian community hospitals are not well understood .", "sentence_id": 0}
+{"abstract_id": "25475461", "label": "methods", "text": "We documented all patients admitted to British Columbia ( BC ) hospitals with a primary diagnosis of NSTEMI between @ and @ .", "sentence_id": 1}
+{"abstract_id": "25475461", "label": "methods", "text": "Patients were divided by admitting hospital type into tertiary care hospitals , nonremote community hospitals , and remote community hospitals .", "sentence_id": 2}
+{"abstract_id": "25475461", "label": "methods", "text": "The aims were to compare transfer rates and time to transfer to a tertiary hospital as well as procedure rates and outcomes at index admission , at @ days , and at @ year .", "sentence_id": 3}
+{"abstract_id": "25475461", "label": "results", "text": "The mean transfer rates to a tertiary hospital were @ % for nonremote and @ % for remote community hospitals ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25475461", "label": "results", "text": "Times to and rates of cardiac procedures differed significantly among these @ hospital types .", "sentence_id": 5}
+{"abstract_id": "25475461", "label": "results", "text": "Admission to a nonremote or remote community hospital was associated with similar @-year mortality compared with admission to a tertiary care hospital ( nonremote hospitals , adjusted odds ratio -LSB- OR -RSB- , @ ; P = @ ; remote hospitals , adjusted OR , @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25475461", "label": "results", "text": "At @ year , admission to a nonremote community hospital was associated with a lower composite outcome of death or readmission for acute myocardial infarction ( AMI ) ( adjusted OR , @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25475461", "label": "conclusions", "text": "One-year mortality rates were not different between patients with NSTEMI admitted to BC community and tertiary care hospitals ; however , the rate of readmission for AMI/death was significantly less in patients admitted to nonremote community hospitals .", "sentence_id": 8}
+{"abstract_id": "25475461", "label": "conclusions", "text": "This should prompt the evaluation of key outcomes in NSTEMI in other community hospital settings .", "sentence_id": 9}
+{"abstract_id": "24636956", "label": "background", "text": "There is limited evidence supporting the podiatric treatment of children with juvenile idiopathic arthritis ( JIA ) .", "sentence_id": 0}
+{"abstract_id": "24636956", "label": "background", "text": "This multicentre randomised controlled trial aimed to determine whether preformed foot orthoses ( FOs ) impacted on pain and quality of life ( QoL ) in children with JIA .", "sentence_id": 1}
+{"abstract_id": "24636956", "label": "methods", "text": "Eligible children were randomised to receive either ` fitted ' FOs with customised chair-side corrections or ` control ' FOs made without corrections .", "sentence_id": 2}
+{"abstract_id": "24636956", "label": "methods", "text": "Changes in pain and QoL were measured using a visual analogue scale and Paediatric Quality of Life questionnaire , respectively .", "sentence_id": 3}
+{"abstract_id": "24636956", "label": "methods", "text": "JIA children were assessed at baseline , @ months and @ months .", "sentence_id": 4}
+{"abstract_id": "24636956", "label": "results", "text": "@ children were recruited .", "sentence_id": 5}
+{"abstract_id": "24636956", "label": "results", "text": "@ out of a possible @ assessments ( @ % ) were completed .", "sentence_id": 6}
+{"abstract_id": "24636956", "label": "results", "text": "A statistically significant greater difference in pain reduction ( baseline - @ months ) was seen between the two groups favouring fitted FOs ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24636956", "label": "results", "text": "The reduction in pain in the fitted FOs group was clinically important ( @ mm ) .", "sentence_id": 8}
+{"abstract_id": "24636956", "label": "results", "text": "Significant differences in QoL favouring fitted FOs were also identified as measured by the children and independently by their parents/carers .", "sentence_id": 9}
+{"abstract_id": "24636956", "label": "conclusions", "text": "Fitted FOs may reduce pain and improve QoL in selected children with JIA .", "sentence_id": 10}
+{"abstract_id": "25288125", "label": "background", "text": "Edgewise fixed orthodontic appliances are available in two different bracket slot sizes ( @ and @ inch ) .", "sentence_id": 0}
+{"abstract_id": "25288125", "label": "background", "text": "Both systems are used by clinicians worldwide with some orthodontists claiming the superiority and clinical advantages of one system over the other .", "sentence_id": 1}
+{"abstract_id": "25288125", "label": "background", "text": "However , the scientific evidence supporting this area is scarce and weak .", "sentence_id": 2}
+{"abstract_id": "25288125", "label": "background", "text": "This leaves the clinician 's choice of bracket slot system to clinical preference .", "sentence_id": 3}
+{"abstract_id": "25288125", "label": "background", "text": "We aim to compare the @-inch and @-inch pre-adjusted bracket slot systems in terms of the effectiveness of orthodontic treatment .", "sentence_id": 4}
+{"abstract_id": "25288125", "label": "methods", "text": "This is a prospective , multicenter , randomized clinical trial , undertaken in the secondary care hospital environment in the NHS Tayside region of Scotland ( United Kingdom ) .", "sentence_id": 5}
+{"abstract_id": "25288125", "label": "methods", "text": "A total of @ orthodontic patients will be recruited in three centers in secondary care hospitals in NHS Tayside .", "sentence_id": 6}
+{"abstract_id": "25288125", "label": "methods", "text": "The participants will be randomly allocated to treatment with either the @-inch or @-inch bracket slot systems ( n = @ for each group ) using Victory series conventional pre-adjusted bracket systems ( @ M Unitek , Monrovia , United States ) .", "sentence_id": 7}
+{"abstract_id": "25288125", "label": "methods", "text": "Baseline records and outcome data collected during and at the end of orthodontic treatment will be assessed .", "sentence_id": 8}
+{"abstract_id": "25288125", "label": "methods", "text": "The primary outcome measures will be the duration of orthodontic treatment in the maxillary and mandibular arches .", "sentence_id": 9}
+{"abstract_id": "25288125", "label": "methods", "text": "The secondary outcome measures will be the number of scheduled appointments for orthodontic treatment in the maxillary and mandibular arches , treatment outcome using Peer Assessment Rating index ( PAR ) , orthodontically induced inflammatory root resorption ( as measured using periapical radiographs ) and the patient 's perception of wearing orthodontic appliances .", "sentence_id": 10}
+{"abstract_id": "25288125", "label": "conclusions", "text": "The results from the current study will serve as evidence to guide the clinician in deciding whether the difference in bracket slot size has a significant impact on the effectiveness of orthodontic treatment .", "sentence_id": 11}
+{"abstract_id": "25141203", "label": "objective", "text": "Compare the effectiveness of Papacarie gel for the chemo-mechanical removal of carious lesions on primary teeth to conventional caries removal with a low-speed bur with regard to execution time , clinical aspects and radiographic findings .", "sentence_id": 0}
+{"abstract_id": "25141203", "label": "methods", "text": "A randomized controlled clinical trial with a split-mouth design was carried out .", "sentence_id": 1}
+{"abstract_id": "25141203", "label": "methods", "text": "The sample was composed of @ children aged four to seven years , in whom @ deciduous teeth were randomly divided into two groups : chemo-mechanical caries removal with Papacarie and removal of carious dentin with a low-speed bur .", "sentence_id": 2}
+{"abstract_id": "25141203", "label": "methods", "text": "Each child underwent both procedures and served as his/her own control .", "sentence_id": 3}
+{"abstract_id": "25141203", "label": "methods", "text": "Restorations were performed with glass ionomer cement .", "sentence_id": 4}
+{"abstract_id": "25141203", "label": "methods", "text": "The time required to perform the procedure was also analyzed .", "sentence_id": 5}
+{"abstract_id": "25141203", "label": "methods", "text": "The patients underwent longitudinal clinical and radiographic follow-up of the restorations .", "sentence_id": 6}
+{"abstract_id": "25141203", "label": "results", "text": "No statistically significant difference between groups was found regarding the time required to perform the procedures and the radiographic follow up .", "sentence_id": 7}
+{"abstract_id": "25141203", "label": "results", "text": "Statistically significant differences between groups were found in the clinical evaluation at @ and @ months after treatment .", "sentence_id": 8}
+{"abstract_id": "25141203", "label": "conclusions", "text": "Papacarie is as effective as the traditional method for the removal of carious dentin on deciduous teeth , but offers the advantages of the preservation of sound dental tissue as well as the avoidance of sharp rotary instruments and local anesthesia .", "sentence_id": 9}
+{"abstract_id": "25551626", "label": "objective", "text": "To examine whether hippotherapy has a clinically significant effect on gross motor function in children with cerebral palsy ( CP ) .", "sentence_id": 0}
+{"abstract_id": "25551626", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25551626", "label": "methods", "text": "Outpatient therapy center .", "sentence_id": 2}
+{"abstract_id": "25551626", "label": "methods", "text": "Ninety-two children with CP , aged @-@ years , presenting variable function ( Gross Motor Function Classification System -LSB- GMFCS -RSB- levels I-IV ) .", "sentence_id": 3}
+{"abstract_id": "25551626", "label": "methods", "text": "Hippotherapy ( @ minutes twice weekly for @ consecutive weeks ) .", "sentence_id": 4}
+{"abstract_id": "25551626", "label": "methods", "text": "Gross Motor Function Measure ( GMFM ) -@ , GMFM-@ , and Pediatric Balance Scale .", "sentence_id": 5}
+{"abstract_id": "25551626", "label": "results", "text": "Pre - and post-treatment measures were completed by @ children ( @ in the intervention group and @ in the control group ) .", "sentence_id": 6}
+{"abstract_id": "25551626", "label": "results", "text": "Differences in improvement on all three measures significantly differed between groups after the @-week study period .", "sentence_id": 7}
+{"abstract_id": "25551626", "label": "results", "text": "Dimensions of GMFM-@ improved significantly after hippotherapy varied by GMFCS level : dimension E in level I , dimensions D and E in level II , dimensions C and D in level III , and dimensions B and C in level IV .", "sentence_id": 8}
+{"abstract_id": "25551626", "label": "conclusions", "text": "Hippotherapy positively affects gross motor function and balance in children with CP of various functional levels .", "sentence_id": 9}
+{"abstract_id": "25249320", "label": "background", "text": "Treatment options for plantar fasciitis have resulted in varied patient outcomes .", "sentence_id": 0}
+{"abstract_id": "25249320", "label": "background", "text": "The aim of this study was to compare a novel treatment , cryopreserved human amniotic membrane ( c-hAM ) , to a traditional treatment , corticosteroid .", "sentence_id": 1}
+{"abstract_id": "25249320", "label": "background", "text": "Our hypothesis was that c-hAM would be safe and comparable to corticosteroids for plantar fasciitis in regard to patient outcomes .", "sentence_id": 2}
+{"abstract_id": "25249320", "label": "methods", "text": "A randomized , controlled , double-blind , single-center pilot study was completed .", "sentence_id": 3}
+{"abstract_id": "25249320", "label": "methods", "text": "Patients were randomized into one of @ treatment groups : c-hAM or corticosteroid .", "sentence_id": 4}
+{"abstract_id": "25249320", "label": "methods", "text": "Patients received an injection at their initial baseline visit with an option for a second injection at their first @-week follow-up .", "sentence_id": 5}
+{"abstract_id": "25249320", "label": "methods", "text": "Total follow-up was obtained for @ weeks after the most recent injection .", "sentence_id": 6}
+{"abstract_id": "25249320", "label": "methods", "text": "The primary outcome measurement was the Foot Health Status Questionnaire ( FHSQ ) .", "sentence_id": 7}
+{"abstract_id": "25249320", "label": "methods", "text": "The secondary outcome measurements were the Visual Analog Scale ( VAS ) and verbally reported percentage improvement .", "sentence_id": 8}
+{"abstract_id": "25249320", "label": "methods", "text": "Data were analyzed between groups for the @ different cohorts ( @ injection versus @ injections ) .", "sentence_id": 9}
+{"abstract_id": "25249320", "label": "methods", "text": "Twenty-three patients had complete follow-up .", "sentence_id": 10}
+{"abstract_id": "25249320", "label": "methods", "text": "Fourteen were randomized to receive corticosteroid and @ were randomized to receive c-hAM .", "sentence_id": 11}
+{"abstract_id": "25249320", "label": "results", "text": "Three patients in each group received second injections .", "sentence_id": 12}
+{"abstract_id": "25249320", "label": "results", "text": "With the numbers available , the majority of outcome measurements showed no statistical difference between groups .", "sentence_id": 13}
+{"abstract_id": "25249320", "label": "results", "text": "The corticosteroid did , however , have greater FHSQ shoe fit improvement ( P = @ ) at @ weeks , FHSQ general health improvement ( P = @ ) at @ weeks , and verbally reported improvement ( P = @ ) at @ weeks in the one-injection cohort .", "sentence_id": 14}
+{"abstract_id": "25249320", "label": "results", "text": "Cryopreserved hAM had greater FHSQ foot pain improvement ( P = @ ) at @ weeks in the @-injection cohort .", "sentence_id": 15}
+{"abstract_id": "25249320", "label": "conclusions", "text": "Cryopreserved hAM injection may be safe and comparable to corticosteroid injection for treatment of plantar fasciitis .", "sentence_id": 16}
+{"abstract_id": "25249320", "label": "conclusions", "text": "This is a pilot study and requires further investigation .", "sentence_id": 17}
+{"abstract_id": "25249320", "label": "methods", "text": "Level I , prospective randomized trial .", "sentence_id": 18}
+{"abstract_id": "24732230", "label": "background", "text": "Placing a central venous access device via the internal jugular or subclavian vein entails significant risks to both patient and healthcare worker .", "sentence_id": 0}
+{"abstract_id": "24732230", "label": "objective", "text": "The purpose of this randomized , prospective study was to determine whether the accelerated Seldinger technique ( AST ) offers significant safety advantages over the modified Seldinger technique ( MST ) for peripherally inserted central catheter insertion .", "sentence_id": 1}
+{"abstract_id": "24732230", "label": "methods", "text": "Patients were randomly assigned to undergo introducer sheath insertion by means of either MST or AST .", "sentence_id": 2}
+{"abstract_id": "24732230", "label": "methods", "text": "Primary outcome measures included time to completion of introducer sheath insertion , estimated blood loss , and success rate .", "sentence_id": 3}
+{"abstract_id": "24732230", "label": "methods", "text": "Secondary outcome measures included vessel-to-air exposure events and unprotected sharps exposure .", "sentence_id": 4}
+{"abstract_id": "24732230", "label": "conclusions", "text": "While both insertion methods proved equivalent for successful vessel cannulation , AST was significantly faster ( P = @ ) and resulted in less blood loss ( P = @ ) than MST .", "sentence_id": 5}
+{"abstract_id": "24732230", "label": "conclusions", "text": "Additionally , AST resulted in significantly fewer vessel-to-air exposure events ( P < @ ) and unprotected sharps exposures ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24732230", "label": "conclusions", "text": "Although this was a relatively small and unblinded study , the high degree of statistical significance of the study results suggests that , for both patients and healthcare workers , AST is faster and safer than MST for PICC peelable introducer sheath insertion .", "sentence_id": 7}
+{"abstract_id": "25504811", "label": "objective", "text": "A significant proportion of patients with rheumatoid arthritis do not respond adequately to biologic treatment .", "sentence_id": 0}
+{"abstract_id": "25504811", "label": "objective", "text": "We hypothesized that lack of response to ( biologic ) disease-modifying antirheumatic drugs ( DMARDs ) is high in patients in whom the subjective , patient-reported component of the Disease Activity Score @ ( DAS@ ) is high at baseline .", "sentence_id": 1}
+{"abstract_id": "25504811", "label": "objective", "text": "The primary aim of our present study was to investigate the contribution of the more subjective versus the objective components of the DAS@ to response to biologic agents in RA patients , as well as the changes in this contribution over time .", "sentence_id": 2}
+{"abstract_id": "25504811", "label": "objective", "text": "The secondary aim was to examine whether the value of this subjective contribution at baseline affects the response to treatment .", "sentence_id": 3}
+{"abstract_id": "25504811", "label": "methods", "text": "The DAS@-P ( the subjective components of the DAS@ relative to the total DAS@ ) was calculated .", "sentence_id": 4}
+{"abstract_id": "25504811", "label": "methods", "text": "Patients were derived from the computer-assisted Management in Early Rheumatoid Arthritis Trial-II and the Biologicals and Outcome Compared and Predicted in Utrecht Region in Rheumatoid Arthritis Study .", "sentence_id": 5}
+{"abstract_id": "25504811", "label": "methods", "text": "Ordinal logistic regression analyses were performed .", "sentence_id": 6}
+{"abstract_id": "25504811", "label": "results", "text": "The DAS@-P score at baseline was not associated with the level of response according to European League Against Rheumatism criteria at @ months .", "sentence_id": 7}
+{"abstract_id": "25504811", "label": "results", "text": "Overall , a significant reduction in the DAS@-P score was observed @ months after start of treatment , showing a greater reduction of the combined subjective components in good responders .", "sentence_id": 8}
+{"abstract_id": "25504811", "label": "conclusions", "text": "The results reject the hypothesis that the lack of response to biologic DMARDs is especially high in patients in whom the patient-reported component of the DAS@ is high at baseline ; these subjective components are not linked to treatment response .", "sentence_id": 9}
+{"abstract_id": "25275368", "label": "background", "text": "Coordination between breathing and swallowing helps prevent aspiration of foreign material into the respiratory tract .", "sentence_id": 0}
+{"abstract_id": "25275368", "label": "background", "text": "The authors examined the effects of anesthesia and hypercapnia on swallowing-breathing coordination .", "sentence_id": 1}
+{"abstract_id": "25275368", "label": "methods", "text": "In a randomized controlled crossover study , general anesthesia with propofol or sevoflurane was titrated using an up-down method to identify the threshold for suppression of the motor response to electrical stimulation of the forearm .", "sentence_id": 2}
+{"abstract_id": "25275368", "label": "methods", "text": "Additional measurements included bispectral index , genioglossus electromyogram , ventilation ( pneumotachometer ) , and hypopharyngeal pressure .", "sentence_id": 3}
+{"abstract_id": "25275368", "label": "methods", "text": "During wakefulness and at each level of anesthesia , carbon dioxide was added to increase the end-tidal pressure by @ and @ mmHg .", "sentence_id": 4}
+{"abstract_id": "25275368", "label": "methods", "text": "A swallow was defined as increased genioglossus activity with deglutition apnea and an increase in hypopharyngeal pressure .", "sentence_id": 5}
+{"abstract_id": "25275368", "label": "methods", "text": "Spontaneous swallows were categorized as physiological ( during expiration or followed by expiration ) or pathological ( during inspiration or followed by an inspiration ) .", "sentence_id": 6}
+{"abstract_id": "25275368", "label": "results", "text": "A total of @ swallows were analyzed .", "sentence_id": 7}
+{"abstract_id": "25275368", "label": "results", "text": "Anesthesia increased the proportion of pathological swallows ( @ % vs. @ % ) and decreased the number of swallows per hour ( @ vs. @ ) compared to wakefulness .", "sentence_id": 8}
+{"abstract_id": "25275368", "label": "results", "text": "During anesthesia , hypercapnia decreased hypopharyngeal pressure during inspiration ( -@ vs. -@ mmHg ) and increased minute ventilation , the proportion of pathological swallows ( @ % vs. @ % ) , and the number of swallows per hour ( @ .", "sentence_id": 9}
+{"abstract_id": "25275368", "label": "results", "text": "vs. @ ) .", "sentence_id": 10}
+{"abstract_id": "25275368", "label": "conclusions", "text": "Anesthesia impaired the coordination between swallowing and respiration .", "sentence_id": 11}
+{"abstract_id": "25275368", "label": "conclusions", "text": "Mild hypercapnia increased the frequency of swallowing during anesthesia and the likelihood of pathological swallowing .", "sentence_id": 12}
+{"abstract_id": "25275368", "label": "conclusions", "text": "During anesthesia , the risk for aspiration may be further increased when ventilatory drive is stimulated .", "sentence_id": 13}
+{"abstract_id": "25256013", "label": "background", "text": "In ruminants , lower ruminal pH causes massive disruption of ruminal epithelial structure during periods of feeding high-concentrate diets .", "sentence_id": 0}
+{"abstract_id": "25256013", "label": "background", "text": "However , the influence of excessive organic fatty acids in the lumen of hindgut on the epithelial structure is unclear .", "sentence_id": 1}
+{"abstract_id": "25256013", "label": "background", "text": "In this study , twelve mid-lactating goats were randomly assigned to either a HC diet group ( @ % concentrate of dry matter ; n = @ ) or a LC diet group ( @ % concentrate of dry matter ; n = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25256013", "label": "background", "text": "The colonic epithelial structure was detected by HE staining and transmission electron microscopy ( TEM ) , and the apoptotic status of epithelial cells was estimated by TUNEL method and caspase activities .", "sentence_id": 3}
+{"abstract_id": "25256013", "label": "results", "text": "HC goats showed higher level of free lipopolysaccharide ( LPS ) in rumen fluid ( p < @ ) but not in colonic digesta ( p > @ ) , and higher total volatile fatty acid ( VFA ) concentrations in rumen fluid ( p < @ ) and in colonic digesta ( p < @ ) , and higher content of starch in colonic digesta ( p < @ ) compared to LC goats .", "sentence_id": 4}
+{"abstract_id": "25256013", "label": "results", "text": "HC goats demonstrated profound alterations in the colonic epithelial structure and tight junctions ( TJ ) , apparently due to damage of the epithelium with widened TJs space and nuclear breakdown and mitochondrial swelling .", "sentence_id": 5}
+{"abstract_id": "25256013", "label": "results", "text": "HC goats showed higher level of apoptosis in the colonic epithelium with higher proportion of TUNEL-positive apoptotic cells and increases of caspase-@ and -@ / @ activities , as well as the lower ratio of bcl-@ / bax mRNA expression in the colonic mucosa ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25256013", "label": "results", "text": "However , - defense mRNA was significantly down-regulated in the colonic mucosa of HC goats compared to LC ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25256013", "label": "results", "text": "HC goats showed higher level of TJ proteins including claudin-@ and claudin-@ in the colonic mucosa than LC ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25256013", "label": "results", "text": "Neither free LPS content in the colonic digesta nor NF - B protein expression in tissues showed significant difference between HC and LC goats ( p > @ ) .", "sentence_id": 9}
+{"abstract_id": "25256013", "label": "conclusions", "text": "Our results reveal that long-term feeding HC diet to lactating goats causes severe damages to the colonic mucosa barrier associated with activating cells apoptosis .", "sentence_id": 10}
+{"abstract_id": "24625322", "label": "background", "text": "Earlier kinetics of serum HCV core antigen ( HCVcAg ) and its predictive value on sustained virological response ( SVR ) were investigated in patients with genotype @ HCV infection during antiviral treatment .", "sentence_id": 0}
+{"abstract_id": "24625322", "label": "methods", "text": "In a multi-centered , randomized and positive drug-controlled phase IIb clinical trial on type Y peginterferon -@ b ( NCT@ ) , forty-eight CHC patients who participated in pharmacokinetics were randomly divided into @ cohorts and treated with PegIFN ( type Y peginterferon -@ b @ g , @ g , @ g and PegIFN-@a @ g , respectively , once a week ) and ribavirin ( < @ kg , @ mg daily and@ kg , @ mg daily ) for @ weeks , and then followed up for @ weeks .", "sentence_id": 1}
+{"abstract_id": "24625322", "label": "methods", "text": "@ patients infected with genotype @ HCV and completed the whole process were included in this study .", "sentence_id": 2}
+{"abstract_id": "24625322", "label": "methods", "text": "HCV RNAs were detected at baseline , and weeks @ , @ , @ , @ and @ using Cobas TaqMan .", "sentence_id": 3}
+{"abstract_id": "24625322", "label": "methods", "text": "ARCHITECT HCVcAg was performed at @ , @ , @ , @ , @ and @ h in addition to the above time points .", "sentence_id": 4}
+{"abstract_id": "24625322", "label": "methods", "text": "The receiver operating curves ( ROCs ) were performed to study the predictive values of HCVcAg decline on SVR .", "sentence_id": 5}
+{"abstract_id": "24625322", "label": "results", "text": "Following antiviral treatment , serum HCVcAg levels rapidly declined within the first week and correlated well with corresponding HCV RNA at baseline , weeks @ , @ , @ , @ and @ ( rs = @ , @ , @ , @ , @ and @ , respectively , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24625322", "label": "results", "text": "All of the areas under the receiver operating curves ( AUROCs ) were more than @ and showed good predictive power on SVR at @ , @ , @ , @ , @ and @ h. The@ h was the best predictive time point of HCVcAg decline on SVR because of its largest AUROC ( more than @ ) .", "sentence_id": 7}
+{"abstract_id": "24625322", "label": "conclusions", "text": "Early kinetics of serum HCVcAg predicts SVR very well in genotype @ CHC patients during antiviral treatment , and its reduction value at @ h is an earlier and stronger predictor on SVR than rapid virological response and early virological response .", "sentence_id": 8}
+{"abstract_id": "24625322", "label": "conclusions", "text": "( TRN : NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "25376971", "label": "background", "text": "The pectoral nerves ( Pecs ) block types I and II are novel techniques to block the pectoral , intercostobrachial , third to sixth intercostals , and the long thoracic nerves .", "sentence_id": 0}
+{"abstract_id": "25376971", "label": "background", "text": "They may provide good analgesia during and after breast surgery .", "sentence_id": 1}
+{"abstract_id": "25376971", "label": "background", "text": "Our study aimed to compare prospectively the quality of analgesia after modified radical mastectomy surgery using general anesthesia and Pecs blocks versus general anesthesia alone .", "sentence_id": 2}
+{"abstract_id": "25376971", "label": "methods", "text": "One hundred twenty adult female patients scheduled for elective unilateral modified radical mastectomy under general anesthesia were randomly allocated to receive either general anesthesia plus Pecs block ( Pecs group , n = @ ) or general anesthesia alone ( control group , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25376971", "label": "results", "text": "Statistically significant lower visual analog scale pain scores were observed in the Pecs group than in the control group patients .", "sentence_id": 4}
+{"abstract_id": "25376971", "label": "results", "text": "Moreover , postoperative morphine consumption in the Pecs group was lower in the first @ hours after surgery than in the control group .", "sentence_id": 5}
+{"abstract_id": "25376971", "label": "results", "text": "In addition , statistically significant lower intraoperative fentanyl consumption was observed in the Pecs group than in the control group .", "sentence_id": 6}
+{"abstract_id": "25376971", "label": "results", "text": "In the postanesthesia care unit , nausea and vomiting as well as sedation scores were lower in the Pecs group compared with the control group .", "sentence_id": 7}
+{"abstract_id": "25376971", "label": "results", "text": "Overall , postanesthesia care unit and hospital stays were shorter in the Pecs group than in the control group .", "sentence_id": 8}
+{"abstract_id": "25376971", "label": "conclusions", "text": "The combined Pecs I and II block is a simple , easy-to-learn technique that produces good analgesia for radical breast surgery .", "sentence_id": 9}
+{"abstract_id": "26223721", "label": "objective", "text": "To investigate the effects of different types of nasal packings on middle ear pressure in patients undergoing septoplasty .", "sentence_id": 0}
+{"abstract_id": "26223721", "label": "methods", "text": "Sixty patients who were suffering from nasal obstruction and who had to undergo septoplasty because of nasal septal deviation were included in the study .", "sentence_id": 1}
+{"abstract_id": "26223721", "label": "methods", "text": "After the septoplasty , Merocel packings and internal nasal splints were intraoperatively applied in thirty patients each .", "sentence_id": 2}
+{"abstract_id": "26223721", "label": "methods", "text": "Middle ear pressure was evaluated by tympanometry .", "sentence_id": 3}
+{"abstract_id": "26223721", "label": "methods", "text": "Tympanometric peak pressures were used for this aim .", "sentence_id": 4}
+{"abstract_id": "26223721", "label": "methods", "text": "Acoustic impedance measurements were performed in both ears , and the average values of the two ears were calculated .", "sentence_id": 5}
+{"abstract_id": "26223721", "label": "methods", "text": "Tympanometric measurements were performed for patients during the preoperative period and on the @ ( nd ) and @ ( th ) postoperative days .", "sentence_id": 6}
+{"abstract_id": "26223721", "label": "results", "text": "There were @ ( @ females , @ males ; average age @ years ) patients in the internal nasal splint group and @ ( @ females , @ males ; average age @ years ) patients in the anterior Merocel packing group .", "sentence_id": 7}
+{"abstract_id": "26223721", "label": "results", "text": "When the values obtained by acoustic impedancemetry before the operation and on the postoperative @ ( th ) day were compared , there was no statistically significant difference between the groups .", "sentence_id": 8}
+{"abstract_id": "26223721", "label": "results", "text": "The middle ear pressure significantly decreased in the anterior Merocel packing group compared with that in the internal nasal splint group .", "sentence_id": 9}
+{"abstract_id": "26223721", "label": "results", "text": "The intragroup comparison of the acoustic impedance measurements of the internal nasal splint group revealed no significant difference between the preoperative acoustic impedance values and the values obtained on the postoperative @ ( nd ) day .", "sentence_id": 10}
+{"abstract_id": "26223721", "label": "conclusions", "text": "Cannulated silicone intranasal splints are better in terms of patient comfort after an intranasal surgery without effecting eustachian tube function .", "sentence_id": 11}
+{"abstract_id": "25171216", "label": "background", "text": "Cerebral palsy refers to permanent , mutable motor development disorders stemming from a primary brain lesion , causing secondary musculoskeletal problems and limitations in activities of daily living .", "sentence_id": 0}
+{"abstract_id": "25171216", "label": "background", "text": "The aim of the present study was to determine the effects of gait training combined with transcranial direct-current stimulation over the primary motor cortex on balance and functional performance in children with cerebral palsy .", "sentence_id": 1}
+{"abstract_id": "25171216", "label": "methods", "text": "A double-blind randomized controlled study was carried out with @ children aged five to @ years with cerebral palsy randomly allocated to two intervention groups ( blocks of six and stratified based on GMFCS level ( levels I-II or level III ) .", "sentence_id": 2}
+{"abstract_id": "25171216", "label": "methods", "text": "The experimental group ( @ children ) was submitted to treadmill training and anodal stimulation of the primary motor cortex .", "sentence_id": 3}
+{"abstract_id": "25171216", "label": "methods", "text": "The control group ( @ children ) was submitted to treadmill training and placebo transcranial direct-current stimulation .", "sentence_id": 4}
+{"abstract_id": "25171216", "label": "methods", "text": "Training was performed in five weekly sessions for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25171216", "label": "methods", "text": "Evaluations consisted of stabilometric analysis as well as the administration of the Pediatric Balance Scale and Pediatric Evaluation of Disability Inventory one week before the intervention , one week after the completion of the intervention and one month after the completion of the intervention .", "sentence_id": 6}
+{"abstract_id": "25171216", "label": "methods", "text": "All patients and two examiners were blinded to the allocation of the children to the different groups .", "sentence_id": 7}
+{"abstract_id": "25171216", "label": "results", "text": "The experimental group exhibited better results in comparison to the control group with regard to anteroposterior sway ( eyes open and closed ; p < @ ) , mediolateral sway ( eyes closed ; p < @ ) and the Pediatric Balance Scale both one week and one month after the completion of the protocol .", "sentence_id": 8}
+{"abstract_id": "25171216", "label": "conclusions", "text": "Gait training on a treadmill combined with anodal stimulation of the primary motor cortex led to improvements in static balance and functional performance in children with cerebral palsy .", "sentence_id": 9}
+{"abstract_id": "24875890", "label": "objective", "text": "To determine the effects of dexmedetomidine premedication on the minimum alveolar concentration of sevoflurane for tracheal intubation ( MACTI ) in children .", "sentence_id": 0}
+{"abstract_id": "24875890", "label": "methods", "text": "Prospective , randomized , clinical comparison study .", "sentence_id": 1}
+{"abstract_id": "24875890", "label": "methods", "text": "Operating room of an academic hospital .", "sentence_id": 2}
+{"abstract_id": "24875890", "label": "methods", "text": "@ pediatric , ASA physical status @ patients , aged @ to @ years , scheduled for minor elective surgery .", "sentence_id": 3}
+{"abstract_id": "24875890", "label": "methods", "text": "Patients were randomized to three groups to receive placebo , dexmedetomidine @ g/kg , or dexmedetomidine @ g/kg approximately @ minutes before anesthesia .", "sentence_id": 4}
+{"abstract_id": "24875890", "label": "methods", "text": "Anesthesia was induced with sevoflurane .", "sentence_id": 5}
+{"abstract_id": "24875890", "label": "methods", "text": "Each concentration of sevoflurane for which a tracheal intubation was attempted was predetermined according to modification of the Dixon 's up-and-down method , with @ % as a step size and held constant for at least @ minutes before tracheal intubation .", "sentence_id": 6}
+{"abstract_id": "24875890", "label": "methods", "text": "All responses ( `` movement '' or `` no movement '' ) to tracheal intubation were assessed .", "sentence_id": 7}
+{"abstract_id": "24875890", "label": "results", "text": "The MACTI of sevoflurane was @ % @ % in the control group , @ % @ % in the @ g/kg dexmedetomidine group , and @ % @ % in the @ g/kg dexmedetomidine group .", "sentence_id": 8}
+{"abstract_id": "24875890", "label": "results", "text": "Dexmedetomidine premedication ( @ and @ g/kg ) decreased the MACTI of sevoflurane by @ % and @ % , respectively .", "sentence_id": 9}
+{"abstract_id": "24875890", "label": "results", "text": "There were no clinically significant episodes of hypotension or bradycardia in any patients .", "sentence_id": 10}
+{"abstract_id": "24875890", "label": "conclusions", "text": "Intranasal dexmedetomidine premedication produces a dose-dependent decrease in the concentration of sevoflurane needed for tracheal intubation in children .", "sentence_id": 11}
+{"abstract_id": "25611944", "label": "objective", "text": "To examine the effect of weight loss on sleep duration , sleep quality , and mood in @ obese men and women who received one of three behavioral weight loss interventions in the Practice-based Opportunities for Weight Reduction trial at the University of Pennsylvania ( POWER-UP ) .", "sentence_id": 0}
+{"abstract_id": "25611944", "label": "methods", "text": "Sleep duration and quality were assessed at baseline and months @ and @ by the Pittsburgh Sleep Quality Index ( PSQI ) questionnaire and mood by the Patient Health Questionnaire-@ ( PHQ-@ ) .", "sentence_id": 1}
+{"abstract_id": "25611944", "label": "methods", "text": "Changes in sleep and mood were examined according to treatment group and based on participants ' having lost @ % of initial weight vs. < @ % .", "sentence_id": 2}
+{"abstract_id": "25611944", "label": "results", "text": "There were few significant differences between treatment groups in changes in sleep or mood .", "sentence_id": 3}
+{"abstract_id": "25611944", "label": "results", "text": "At month @ , however , mean ( SD ) min of sleep increased significantly more in participants who lost @ % vs. < @ % ( @ vs. @ min , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25611944", "label": "results", "text": "PSQI total scores similarly improved ( declined ) more in those who lost @ % vs. < @ % ( -@ vs. -@ , P < @ ) , as did PHQ-@ scores ( -@ vs. -@ , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25611944", "label": "results", "text": "At month @ , only the differences in mood remained statistically significant ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25611944", "label": "conclusions", "text": "Losing @ % of initial weight was associated with short-term improvements in sleep duration and sleep quality , as well as favorable short - and long-term changes in mood .", "sentence_id": 7}
+{"abstract_id": "25219423", "label": "objective", "text": "The STRIDE study assessed whether a lifestyle intervention , tailored for individuals with serious mental illnesses , reduced weight and diabetes risk .", "sentence_id": 0}
+{"abstract_id": "25219423", "label": "objective", "text": "The authors hypothesized that the STRIDE intervention would be more effective than usual care in reducing weight and improving glucose metabolism .", "sentence_id": 1}
+{"abstract_id": "25219423", "label": "methods", "text": "The study design was a multisite , parallel two-arm randomized controlled trial in community settings and an integrated health plan .", "sentence_id": 2}
+{"abstract_id": "25219423", "label": "methods", "text": "Participants who met inclusion criteria were @ years old , were taking antipsychotic agents for @ days , and had a body mass index @ .", "sentence_id": 3}
+{"abstract_id": "25219423", "label": "methods", "text": "Exclusions were significant cognitive impairment , pregnancy/breastfeeding , recent psychiatric hospitalization , bariatric surgery , cancer , heart attack , or stroke .", "sentence_id": 4}
+{"abstract_id": "25219423", "label": "methods", "text": "The intervention emphasized moderate caloric reduction , the DASH ( Dietary Approaches to Stop Hypertension ) diet , and physical activity .", "sentence_id": 5}
+{"abstract_id": "25219423", "label": "methods", "text": "Blinded staff collected data at baseline , @ months , and @ months .", "sentence_id": 6}
+{"abstract_id": "25219423", "label": "results", "text": "Participants ( men , N = @ ; women , N = @ ; mean age = @ years -LSB- SD = @ -RSB- ) were randomly assigned to usual care ( N = @ ) or a @-month weekly group intervention plus six monthly maintenance sessions ( N = @ ) .", "sentence_id": 7}
+{"abstract_id": "25219423", "label": "results", "text": "A total of @ participants ( @ % ) completed @-month assessments , and @ ( @ % ) completed @-month assessments , without differential attrition .", "sentence_id": 8}
+{"abstract_id": "25219423", "label": "results", "text": "Participants attended @ of @ sessions over @ months .", "sentence_id": 9}
+{"abstract_id": "25219423", "label": "results", "text": "Intent-to-treat analyses revealed that intervention participants lost @ kg more than control participants from baseline to @ months ( @ % CI = -@ kg to -@ kg ) and @ kg more than control participants from baseline to @ months ( @ % CI = -@ kg to -@ kg ) .", "sentence_id": 10}
+{"abstract_id": "25219423", "label": "results", "text": "At @ months , fasting glucose levels in the control group had increased from @ mg/dL to @ mg/dL and decreased in the intervention group from @ mg/dL to @ mg/dL .", "sentence_id": 11}
+{"abstract_id": "25219423", "label": "results", "text": "No serious adverse events were study-related ; medical hospitalizations were reduced in the intervention group ( @ % ) compared with the control group ( @ % ) .", "sentence_id": 12}
+{"abstract_id": "25219423", "label": "conclusions", "text": "Individuals taking antipsychotic medications can lose weight and improve fasting glucose levels .", "sentence_id": 13}
+{"abstract_id": "25219423", "label": "conclusions", "text": "Increasing reach of the intervention is an important future step .", "sentence_id": 14}
+{"abstract_id": "24495287", "label": "background", "text": "Verbal autopsy ( VA ) has been proposed to determine the cause of death ( COD ) distributions in settings where most deaths occur without medical attention or certification .", "sentence_id": 0}
+{"abstract_id": "24495287", "label": "background", "text": "We develop performance criteria for VA-based COD systems and apply these to the Registrar General of India 's ongoing , nationally-representative Indian Million Death Study ( MDS ) .", "sentence_id": 1}
+{"abstract_id": "24495287", "label": "methods", "text": "Performance criteria include a low ill-defined proportion of deaths before old age ; reproducibility , including consistency of COD distributions with independent resampling ; differences in COD distribution of hospital , home , urban or rural deaths ; age - , sex - and time-specific plausibility of specific diseases ; stability and repeatability of dual physician coding ; and the ability of the mortality classification system to capture a wide range of conditions .", "sentence_id": 2}
+{"abstract_id": "24495287", "label": "results", "text": "The introduction of the MDS in India reduced the proportion of ill-defined deaths before age @ years from @ % to @ % .", "sentence_id": 3}
+{"abstract_id": "24495287", "label": "results", "text": "The cause-specific mortality fractions ( CSMFs ) at ages @ to @ years for independently resampled deaths and the MDS were very similar across @ disease categories .", "sentence_id": 4}
+{"abstract_id": "24495287", "label": "results", "text": "By contrast , CSMFs at these ages differed between hospital and home deaths and between urban and rural deaths .", "sentence_id": 5}
+{"abstract_id": "24495287", "label": "results", "text": "Thus , reliance mostly on urban or hospital data can distort national estimates of CODs .", "sentence_id": 6}
+{"abstract_id": "24495287", "label": "results", "text": "Age - , sex - and time-specific patterns for various diseases were plausible .", "sentence_id": 7}
+{"abstract_id": "24495287", "label": "results", "text": "Initial physician agreement on COD occurred about two-thirds of the time .", "sentence_id": 8}
+{"abstract_id": "24495287", "label": "results", "text": "The MDS COD classification system was able to capture more eligible records than alternative classification systems .", "sentence_id": 9}
+{"abstract_id": "24495287", "label": "results", "text": "By these metrics , the Indian MDS performs well for deaths prior to age @ years .", "sentence_id": 10}
+{"abstract_id": "24495287", "label": "results", "text": "The key implication for low - and middle-income countries where medical certification of death remains uncommon is to implement COD surveys that randomly sample all deaths , use simple but high-quality field work with built-in resampling , and use electronic rather than paper systems to expedite field work and coding .", "sentence_id": 11}
+{"abstract_id": "24495287", "label": "conclusions", "text": "Simple criteria can evaluate the performance of VA-based COD systems .", "sentence_id": 12}
+{"abstract_id": "24495287", "label": "conclusions", "text": "Despite the misclassification of VA , the MDS demonstrates that national surveys of CODs using VA are an order of magnitude better than the limited COD data previously available .", "sentence_id": 13}
+{"abstract_id": "25409776", "label": "background", "text": "Depression accounts for the greatest disease burden of all mental health disorders , contributes heavily to healthcare costs , and by @ is set to become the second largest cause of global disability .", "sentence_id": 0}
+{"abstract_id": "25409776", "label": "background", "text": "Although @ % to @ % of people aged @ years and over are likely to experience depressive symptoms , the condition is under-diagnosed and often inadequately treated in primary care .", "sentence_id": 1}
+{"abstract_id": "25409776", "label": "background", "text": "Later-life depression is associated with chronic illness and disability , cognitive impairment and social isolation .", "sentence_id": 2}
+{"abstract_id": "25409776", "label": "background", "text": "With a progressively ageing population it becomes increasingly important to refine strategies to identity and manage depression in older people .", "sentence_id": 3}
+{"abstract_id": "25409776", "label": "background", "text": "Currently , management may be limited to the prescription of antidepressants where there may be poor concordance ; older people may lack awareness of psychosocial interventions and general practitioners may neglect to offer this treatment option .", "sentence_id": 4}
+{"abstract_id": "25409776", "label": "methods", "text": "CASPER Plus is a multi-centre , randomised controlled trial of a collaborative care intervention for individuals aged @ years and over experiencing moderate to severe depression .", "sentence_id": 5}
+{"abstract_id": "25409776", "label": "methods", "text": "Selected practices in the North of England identify potentially eligible patients and invite them to participate in the study .", "sentence_id": 6}
+{"abstract_id": "25409776", "label": "methods", "text": "A diagnostic interview is carried out and participants with major depressive disorder are randomised to either collaborative care or usual care .", "sentence_id": 7}
+{"abstract_id": "25409776", "label": "methods", "text": "The recruitment target is @ participants .", "sentence_id": 8}
+{"abstract_id": "25409776", "label": "methods", "text": "The intervention , behavioural activation and medication management in a collaborative care framework , has been adapted to meet the complex needs of older people .", "sentence_id": 9}
+{"abstract_id": "25409776", "label": "methods", "text": "It is delivered over eight to @ weekly sessions by a case manager liaising with general practitioners .", "sentence_id": 10}
+{"abstract_id": "25409776", "label": "methods", "text": "The trial aims to evaluate the clinical and cost effectiveness of collaborative care in addition to usual GP care versus usual GP care alone .", "sentence_id": 11}
+{"abstract_id": "25409776", "label": "methods", "text": "The primary clinical outcome , depression severity , will be measured with the Patient Health Questionnaire-@ ( PHQ-@ ) at baseline , @ , @ and @ months .", "sentence_id": 12}
+{"abstract_id": "25409776", "label": "methods", "text": "Cost effectiveness analysis will assess health-related quality of life using the SF-@ and EQ-@D and will examine cost-consequences of collaborative care .", "sentence_id": 13}
+{"abstract_id": "25409776", "label": "methods", "text": "A qualitative process evaluation will be undertaken to explore acceptability , gauge the extent to which the intervention is implemented and to explore sustainability beyond the clinical trial .", "sentence_id": 14}
+{"abstract_id": "25409776", "label": "conclusions", "text": "Results will add to existing evidence and a positive outcome may lead to the commissioning of this model of service in primary care .", "sentence_id": 15}
+{"abstract_id": "24901823", "label": "background", "text": "Endoscopic placement of a iodine-@ radioactive stent is useful to treat obstructive jaundice with unresectable periampullary tumors .", "sentence_id": 0}
+{"abstract_id": "24901823", "label": "background", "text": "This study aimed to retrospectively evaluate the obstructive component of biliary radioactive stents and discuss the different obstructive mechanism with common plastic stents .", "sentence_id": 1}
+{"abstract_id": "24901823", "label": "methods", "text": "Twenty consecutive patients with malignant obstruction underwent insertion of stents into the common bile duct , including @ radioactive stents and @ polyethylene stents .", "sentence_id": 2}
+{"abstract_id": "24901823", "label": "methods", "text": "The radioactive stents were withdrawn after @ months or earlier if clinical signs suggested stent clogging .", "sentence_id": 3}
+{"abstract_id": "24901823", "label": "methods", "text": "Polyethylene stents were withdrawn after physical signs suggested stent clogging .", "sentence_id": 4}
+{"abstract_id": "24901823", "label": "methods", "text": "Bacteriologic analyses included identification of aerobic and anaerobic bacteria .", "sentence_id": 5}
+{"abstract_id": "24901823", "label": "methods", "text": "Stent surfaces were observed by scanning electron microscopy .", "sentence_id": 6}
+{"abstract_id": "24901823", "label": "methods", "text": "Stent deposition was identified by Fourier-transformed infrared spectroscopy and pyrolysis derivatization/gas chromatography/mass spectrometry .", "sentence_id": 7}
+{"abstract_id": "24901823", "label": "results", "text": "Radioactive stent group and polyethylene stent group stents were placed for @ days ( interquartile range @ , @ ) and @ days ( interquartile range @ , @ ) respectively .", "sentence_id": 8}
+{"abstract_id": "24901823", "label": "results", "text": "The placement duration of the two types of stents was statistically significant .", "sentence_id": 9}
+{"abstract_id": "24901823", "label": "results", "text": "A variety of microorganisms were cultured from the stent deposits .", "sentence_id": 10}
+{"abstract_id": "24901823", "label": "results", "text": "Scanning electron microscope images showed a thicker necrotic layer on the external surface of polyethylene stent than the radioactive stent group .", "sentence_id": 11}
+{"abstract_id": "24901823", "label": "results", "text": "The proportions of obstructive components in each stent were different , but none of them were statistically significant .", "sentence_id": 12}
+{"abstract_id": "24901823", "label": "results", "text": "Necrotic tumor tissue was found in the radioactive stent group .", "sentence_id": 13}
+{"abstract_id": "24901823", "label": "conclusions", "text": "Similar clogging events occurred in both radioactive stents and polyethylene stents .", "sentence_id": 14}
+{"abstract_id": "24901823", "label": "conclusions", "text": "The median duration time of the radioactive stent was shorter , probably because of the smaller inner diameter , and the radioactive seeds exerted no beneficial effect in inhibiting microorganisms .", "sentence_id": 15}
+{"abstract_id": "24239154", "label": "background", "text": "Previous studies on cognitive and interpersonal interventions have yielded inconsistent results in ischemic heart disease patients .", "sentence_id": 0}
+{"abstract_id": "24239154", "label": "methods", "text": "@ patients aged @ years , and enrolled one week after complete revascularization with urgent/emergent angioplasty for an AMI , were randomized to standard cardiological therapy plus short-term humanistic-existential psychotherapy ( STP ) versus standard cardiological therapy only .", "sentence_id": 1}
+{"abstract_id": "24239154", "label": "methods", "text": "Primary composite end point was : one-year incidence of new cardiological events ( re-infarction , death , stroke , revascularization , life-threatening ventricular arrhythmias , and the recurrence of typical and clinically significant angina ) and of clinically significant new comorbidities .", "sentence_id": 2}
+{"abstract_id": "24239154", "label": "methods", "text": "Secondary end points were : rates for individual components of the primary outcome , incidence of re-hospitalizations for cardiological problems , New York Heart Association class , and psychometric test scores at follow-up .", "sentence_id": 3}
+{"abstract_id": "24239154", "label": "results", "text": "@ patients were analyzed at one year .", "sentence_id": 4}
+{"abstract_id": "24239154", "label": "results", "text": "The two treatment groups were similar across all baseline characteristics .", "sentence_id": 5}
+{"abstract_id": "24239154", "label": "results", "text": "At follow-up , STP patients had had a lower incidence of the primary endpoint , relative to controls ( @/@ vs. @/@ patients ; p = @ , respectively ; NNT = @ ) ; this benefit was attributable to the lower incidence of recurrent angina and of new comorbidities in the STP group ( @/@ vs. @/@ patients , p = @ , NNT = @ ; and @/@ vs. @/@ , p < @ , NNT = @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "24239154", "label": "results", "text": "Patients undergoing STP also had statistically fewer re-hospitalizations , a better NYHA class , higher quality of life , and lower depression scores .", "sentence_id": 7}
+{"abstract_id": "24239154", "label": "conclusions", "text": "Adding STP to cardiological therapy improves cardiological symptoms , quality of life , and psychological and medical outcomes one year post AMI , while reducing the need for re-hospitalizations .", "sentence_id": 8}
+{"abstract_id": "24239154", "label": "conclusions", "text": "Larger studies remain necessary to confirm the generalizability of these results .", "sentence_id": 9}
+{"abstract_id": "24951828", "label": "background", "text": "Noroviruses are the most important viral causes of gastroenteritis-related morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "24951828", "label": "background", "text": "A randomized , double-blind , placebo-controlled study evaluated an adjuvanted bivalent intramuscular norovirus virus-like particle ( VLP ) vaccine .", "sentence_id": 1}
+{"abstract_id": "24951828", "label": "methods", "text": "Forty-eight adults aged @-@ years received either @ doses containing genotype GI @ VLP and a consensus GII @ VLP or @ doses of placebo .", "sentence_id": 2}
+{"abstract_id": "24951828", "label": "methods", "text": "Doses ( @ g , @ g , @ g , or @ g of each VLP ) were administered @ weeks apart in the first stage .", "sentence_id": 3}
+{"abstract_id": "24951828", "label": "methods", "text": "Subsequently , @ adults , aged @-@ ( n = @ ) , @-@ ( n = @ ) , and @-@ ( n = @ ) years , received @ doses of vaccine containing @ g of each VLP .", "sentence_id": 4}
+{"abstract_id": "24951828", "label": "methods", "text": "Total and class-specific antibody responses , as well as histoblood group antigen ( HBGA ) blocking antibody responses , were measured before and after each dose .", "sentence_id": 5}
+{"abstract_id": "24951828", "label": "results", "text": "Local reactions were mainly injection site pain/tenderness , with no reported fever or vaccine-related serious adverse events .", "sentence_id": 6}
+{"abstract_id": "24951828", "label": "results", "text": "One dose of vaccine containing @ g of each VLP increased GI @ geometric mean titers ( GMTs ) by @-fold , @-fold , and @-fold and increased GII @ GMTs by @-fold , @-fold , and @-fold in subjects aged @-@ , @-@ , and @-@ years , respectively .", "sentence_id": 7}
+{"abstract_id": "24951828", "label": "results", "text": "Serum antibody responses peaked at day @ after the first dose , with no evidence of boosting following a second dose .", "sentence_id": 8}
+{"abstract_id": "24951828", "label": "results", "text": "Most subjects achieved HBGA-blocking antibody titers of @ .", "sentence_id": 9}
+{"abstract_id": "24951828", "label": "conclusions", "text": "The vaccine was well tolerated and immunogenic .", "sentence_id": 10}
+{"abstract_id": "24951828", "label": "conclusions", "text": "Rapid immune response to a single dose may be particularly useful in military personnel and travelers and in the control of outbreaks .", "sentence_id": 11}
+{"abstract_id": "24951828", "label": "conclusions", "text": "Clinical Trials Registration.NCT@ .", "sentence_id": 12}
+{"abstract_id": "24901635", "label": "background", "text": "The threshold values of rapid shallow breathing index ( RSBI ) were compared in pressure support ventilation ( PSV ) and T-piece assessments for spontaneous breathing trials ( SBT ) .", "sentence_id": 0}
+{"abstract_id": "24901635", "label": "background", "text": "The ability of RSBI to also predict successful weaning was evaluated .", "sentence_id": 1}
+{"abstract_id": "24901635", "label": "methods", "text": "Two hundred eight patients were weaned from mechanical ventilation through oral intubation .", "sentence_id": 2}
+{"abstract_id": "24901635", "label": "methods", "text": "They were randomly divided into PSV group ( n = @ ) and T-piece group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24901635", "label": "methods", "text": "The RSBI was calculated as f/VT at SBT of @ and @ minutes .", "sentence_id": 4}
+{"abstract_id": "24901635", "label": "methods", "text": "Receiver operating characteristic curves of RSBI were also generated , cutoff values were determined and the changes in the RSBI were calculated .", "sentence_id": 5}
+{"abstract_id": "24901635", "label": "results", "text": "Of the @ patients , @ ( @ % ) were successfully weaned from mechanical ventilation , @/@ ( @ % ) in the PSV group and @/@ ( @ % ) in the T-piece group ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24901635", "label": "results", "text": "In the PSV and T-piece groups , the average RSBI at @-minute SBT was @ @ breaths per min/L and @ @ breaths per min/L , respectively ( P < @ ) , and the average RSBI was @ @ % and @ @ % , respectively ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24901635", "label": "results", "text": "Additionally , in the @ groups , an RSBI of @ breaths per min/L ( PSV ) and @ breaths per min/L ( T-piece ) yielded a diagnostic accuracy of @ % and @ % respectively .", "sentence_id": 8}
+{"abstract_id": "24901635", "label": "results", "text": "However , a RSBI of @ % ( PSV ) and @ % ( T-piece ) yielded a diagnostic accuracy of @ % and @ % respectively .", "sentence_id": 9}
+{"abstract_id": "24901635", "label": "conclusions", "text": "The threshold values of RSBI , thus @ breaths per min/L ( PSV ) and @ breaths per min/L ( T-piece ) , for predicting successful weaning were more accurate than other values .", "sentence_id": 10}
+{"abstract_id": "24901635", "label": "conclusions", "text": "Similarly , the change in the RSBI could also predict such successes .", "sentence_id": 11}
+{"abstract_id": "24532547", "label": "background", "text": "Continuous long-term treatment with nitrates may cause nitrate tolerance .", "sentence_id": 0}
+{"abstract_id": "24532547", "label": "background", "text": "Nebivolol is a highly selective beta@-adrenergic antagonist with additional nitric oxide ( NO ) - mediated vasodilatory effects .", "sentence_id": 1}
+{"abstract_id": "24532547", "label": "background", "text": "However , there have been no investigations into whether or not the long-term administration of nebivolol might cause nitrate tolerance .", "sentence_id": 2}
+{"abstract_id": "24532547", "label": "methods", "text": "We performed a randomized , double-blind , placebo-controlled , cross-over study in @ healthy men .", "sentence_id": 3}
+{"abstract_id": "24532547", "label": "methods", "text": "Subjects received @ mg nebivolol or placebo once daily for @ days in random order divided by a drug-free interval of @ weeks .", "sentence_id": 4}
+{"abstract_id": "24532547", "label": "methods", "text": "Forearm blood flow ( FBF ) was measured by venous occlusion plethysmography @ h after oral intake of the first and last doses of nebivolol and placebo , respectively .", "sentence_id": 5}
+{"abstract_id": "24532547", "label": "methods", "text": "FBF was measured again following the intravenous administration of @ g nitroglycerin/kg body weight/min for @ min .", "sentence_id": 6}
+{"abstract_id": "24532547", "label": "results", "text": "Following @ days of continuous intake of placebo , nitroglycerin increased FBF by @ % ( p < @ ) , whereas nitroglycerin increased FBF by @ % ( p < @ ) following @ days of continuous intake of nebivolol , and the increase after @ days of nebivolol was significantly ( p < @ ) more pronounced than after @ days of placebo .", "sentence_id": 7}
+{"abstract_id": "24532547", "label": "conclusions", "text": "These findings indicate no evidence of nitrate tolerance caused by long-term administration of nebivolol .", "sentence_id": 8}
+{"abstract_id": "24532547", "label": "conclusions", "text": "On the contrary , long-term intake of nebivolol increases rather than decreases the NO-mediated vasodilating effects .", "sentence_id": 9}
+{"abstract_id": "25230595", "label": "background", "text": "Most patients with extensive stage small-cell lung cancer ( ES-SCLC ) who undergo chemotherapy , and prophylactic cranial irradiation , have persistent intrathoracic disease .", "sentence_id": 0}
+{"abstract_id": "25230595", "label": "background", "text": "We assessed thoracic radiotherapy for treatment of this patient group .", "sentence_id": 1}
+{"abstract_id": "25230595", "label": "methods", "text": "We did this phase @ randomised controlled trial at @ hospitals : @ in Netherlands , @ in the UK , three in Norway , and one in Belgium .", "sentence_id": 2}
+{"abstract_id": "25230595", "label": "methods", "text": "We enrolled patients with WHO performance score @-@ and confirmed ES-SCLC who responded to chemotherapy .", "sentence_id": 3}
+{"abstract_id": "25230595", "label": "methods", "text": "They were randomly assigned ( @:@ ) to receive either thoracic radiotherapy ( @ Gy in ten fractions ) or no thoracic radiotherapy .", "sentence_id": 4}
+{"abstract_id": "25230595", "label": "methods", "text": "All underwent prophylactic cranial irradiation .", "sentence_id": 5}
+{"abstract_id": "25230595", "label": "methods", "text": "The primary endpoint was overall survival at @ year in the intention-to-treat population .", "sentence_id": 6}
+{"abstract_id": "25230595", "label": "methods", "text": "Secondary endpoints included progression-free survival .", "sentence_id": 7}
+{"abstract_id": "25230595", "label": "methods", "text": "This study is registered with the Nederlands Trial Register , number NTR@ .", "sentence_id": 8}
+{"abstract_id": "25230595", "label": "results", "text": "We randomly assigned @ patients between Feb @ , @ , and Dec @ , @ .", "sentence_id": 9}
+{"abstract_id": "25230595", "label": "results", "text": "Three withdrew informed consent , leaving @ patients in the thoracic radiotherapy group and @ in the control group .", "sentence_id": 10}
+{"abstract_id": "25230595", "label": "results", "text": "Mean interval between diagnosis and randomisation was @ weeks .", "sentence_id": 11}
+{"abstract_id": "25230595", "label": "results", "text": "Median follow-up was @ months .", "sentence_id": 12}
+{"abstract_id": "25230595", "label": "results", "text": "Overall survival at @ year was not significantly different between groups : @ % ( @ % CI @-@ ) for the thoracic radiotherapy group versus @ % ( @ % CI @-@ ) for the control group ( hazard ratio -LSB- HR -RSB- @ , @ % CI @-@ @ ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25230595", "label": "results", "text": "However , in a secondary analysis , @-year overall survival was @ % ( @ % CI @-@ ) versus @ % ( @ % CI @-@ ; p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25230595", "label": "results", "text": "Progression was less likely in the thoracic radiotherapy group than in the control group ( HR @ , @ % CI @-@ @ ; p = @ ) .", "sentence_id": 15}
+{"abstract_id": "25230595", "label": "results", "text": "At @ months , progression-free survival was @ % ( @ % CI @-@ ) versus @ % ( @ % CI @-@ ; p = @ ) .", "sentence_id": 16}
+{"abstract_id": "25230595", "label": "results", "text": "We recorded no severe toxic effects .", "sentence_id": 17}
+{"abstract_id": "25230595", "label": "results", "text": "The most common grade @ or higher toxic effects were fatigue ( @ vs @ ) and dyspnoea ( three vs four ) .", "sentence_id": 18}
+{"abstract_id": "25230595", "label": "conclusions", "text": "Thoracic radiotherapy in addition to prophylactic cranial irradiation should be considered for all patients with ES-SCLC who respond to chemotherapy .", "sentence_id": 19}
+{"abstract_id": "24781851", "label": "objective", "text": "The aim of this study was to test the efficacy of a @-month lifestyle intervention in improving cardiovascular disease risk factors in community-based menopausal transition and early postmenopausal women in China .", "sentence_id": 0}
+{"abstract_id": "24781851", "label": "methods", "text": "One hundred healthy menopausal transition and early postmenopausal women aged @ to @ years were randomly assigned to receive either lifestyle change intervention ( n = @ ) or usual care ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24781851", "label": "methods", "text": "Menopause status was defined by the menstrual change criteria of the Stages of Reproductive Aging Workshop + @ based on prospective menstrual calendars .", "sentence_id": 2}
+{"abstract_id": "24781851", "label": "methods", "text": "Women in the intervention group were provided with a colorful booklet that included dietary and physical activity recommendations , were individually interviewed , and completed biophysical cardiovascular risk assessments at the Women 's Health Center ( Beijing , China ) .", "sentence_id": 3}
+{"abstract_id": "24781851", "label": "methods", "text": "Women were encouraged to follow a healthy eating pattern and to increase their aerobic activity ( moderate level , @ d/wk , @ min/d ) .", "sentence_id": 4}
+{"abstract_id": "24781851", "label": "methods", "text": "Women in the control group continued their usual eating patterns and activities .", "sentence_id": 5}
+{"abstract_id": "24781851", "label": "methods", "text": "Weight , body mass index ( BMI ) , waist circumference-to-hip circumference ratio ( WHR ) , waist circumference ( WC ) , body composition , blood pressure ( BP ) , blood glucose , and serum lipids were assessed at baseline , @ months , @ months , and @ months in both groups .", "sentence_id": 6}
+{"abstract_id": "24781851", "label": "results", "text": "Women in the intervention group were observed to have significant decreases in weight , BMI , WC , WHR , systolic BP , total cholesterol , and low-density lipoprotein cholesterol compared with women in the control group .", "sentence_id": 7}
+{"abstract_id": "24781851", "label": "results", "text": "At @ months , there were significant decreases in weight ( -@ vs @ kg , P = @ ) , BMI ( -@ vs @ kg/m@ , P = @ ) , WC ( -@ vs @ cm , P = @ ) , and WHR ( -@ vs @ , P = @ ) in the intervention group compared with the control group .", "sentence_id": 8}
+{"abstract_id": "24781851", "label": "results", "text": "At @ months , there were significant decreases in WC ( -@ vs @ cm , P = @ ) , WHR ( -@ vs -@ , P = @ ) , and systolic BP ( -@ vs -@ mm Hg , P = @ ) favoring the intervention group over the control group .", "sentence_id": 9}
+{"abstract_id": "24781851", "label": "results", "text": "At @ months , there were significant decreases in total cholesterol ( -@ vs @ mmol/L , P = @ ) and low-density lipoprotein cholesterol ( -@ vs @ mmol/L , P = @ ) in the intervention group versus the control group .", "sentence_id": 10}
+{"abstract_id": "24781851", "label": "conclusions", "text": "Lifestyle intervention may be an effective means for reducing cardiovascular disease risk factors in menopausal transition and early postmenopausal women in China .", "sentence_id": 11}
+{"abstract_id": "25005651", "label": "objective", "text": "Ninety percent of cases of acute calculous cholecystitis are of mild ( grade I ) or moderate ( grade II ) severity .", "sentence_id": 0}
+{"abstract_id": "25005651", "label": "objective", "text": "Although the preoperative and intraoperative antibiotic management of acute calculous cholecystitis has been standardized , few data exist on the utility of postoperative antibiotic treatment .", "sentence_id": 1}
+{"abstract_id": "25005651", "label": "objective", "text": "To determine the effect of postoperative amoxicillin plus clavulanic acid on infection rates after cholecystectomy .", "sentence_id": 2}
+{"abstract_id": "25005651", "label": "methods", "text": "A total of @ patients treated at @ medical centers for grade I or II acute calculous cholecystitis and who received @ g of amoxicillin plus clavulanic acid @ times a day while in the hospital before and once at the time of surgery were randomized after surgery to an open-label , noninferiority , randomized clinical trial between May @ and August @ .", "sentence_id": 3}
+{"abstract_id": "25005651", "label": "methods", "text": "After surgery , no antibiotics or continue with the preoperative antibiotic regimen @ times daily for @ days .", "sentence_id": 4}
+{"abstract_id": "25005651", "label": "methods", "text": "The proportion of postoperative surgical site or distant infections recorded before or at the @-week follow-up visit .", "sentence_id": 5}
+{"abstract_id": "25005651", "label": "results", "text": "An imputed intention-to-treat analysis of @ patients showed that the postoperative infection rates were @ % ( @ of @ ) in the nontreatment group and @ % ( @ of @ ) in the antibiotic group ( absolute difference , @ % ; @ % CI , -@ % to @ % ) .", "sentence_id": 6}
+{"abstract_id": "25005651", "label": "results", "text": "In the per-protocol analysis , which involved @ patients , the corresponding rates were both @ % ( absolute difference , @ % ; @ % CI , -@ % to @ % ) .", "sentence_id": 7}
+{"abstract_id": "25005651", "label": "results", "text": "Based on a noninferiority margin of @ % , the lack of postoperative antibiotic treatment was not associated with worse outcomes than antibiotic treatment .", "sentence_id": 8}
+{"abstract_id": "25005651", "label": "results", "text": "Bile cultures showed that @ % were pathogen free .", "sentence_id": 9}
+{"abstract_id": "25005651", "label": "results", "text": "Both groups had similar Clavien complication severity outcomes : @ patients ( @ % ) in the nontreatment group had a score of @ to I and @ patients ( @ % ) had a score of III to V , and @ patients ( @ % ) in the antibiotic group had a score of @ to I and @ patients ( @ % ) had a score of III to V.", "sentence_id": 10}
+{"abstract_id": "25005651", "label": "conclusions", "text": "Among patients with mild or moderate calculous cholecystitis who received preoperative and intraoperative antibiotics , lack of postoperative treatment with amoxicillin plus clavulanic acid did not result in a greater incidence of postoperative infections .", "sentence_id": 11}
+{"abstract_id": "25195059", "label": "objective", "text": "To expose residents to two methods of education for point-of-care ultrasound , a traditional didactic lecture and a model/simulation-based lecture , which focus on concepts of cardiopulmonary function , volume status , and evaluation of severe thoracic/abdominal injuries ; and to assess which method is more effective .", "sentence_id": 0}
+{"abstract_id": "25195059", "label": "methods", "text": "Single-center , prospective , blinded trial .", "sentence_id": 1}
+{"abstract_id": "25195059", "label": "methods", "text": "University hospital .", "sentence_id": 2}
+{"abstract_id": "25195059", "label": "methods", "text": "Anesthesiology residents who were assigned to an educational day during the two-month research study period .", "sentence_id": 3}
+{"abstract_id": "25195059", "label": "methods", "text": "Residents were allocated to two groups to receive either a @-minute , one-on-one didactic lecture or a @-minute lecture in a simulation center , during which they practiced on a human model and simulation mannequin ( normal pathology ) .", "sentence_id": 4}
+{"abstract_id": "25195059", "label": "methods", "text": "Data points included a pre-lecture multiple-choice test , post-lecture multiple-choice test , and post-lecture , human model-based examination .", "sentence_id": 5}
+{"abstract_id": "25195059", "label": "methods", "text": "Post-lecture tests were performed within three weeks of the lecture .", "sentence_id": 6}
+{"abstract_id": "25195059", "label": "methods", "text": "An experienced sonographer who was blinded to the education modality graded the model-based skill assessment examinations .", "sentence_id": 7}
+{"abstract_id": "25195059", "label": "methods", "text": "Participants completed a follow-up survey to assess the perceptions of the quality of their instruction between the two groups .", "sentence_id": 8}
+{"abstract_id": "25195059", "label": "results", "text": "@ residents completed the study .", "sentence_id": 9}
+{"abstract_id": "25195059", "label": "results", "text": "No differences were noted between the two groups in pre-lecture test scores ( P = @ ) , but significantly higher scores for the model/simulation group occurred on both the post-lecture multiple choice ( P = @ ) and post-lecture model ( P = @ ) examinations .", "sentence_id": 10}
+{"abstract_id": "25195059", "label": "results", "text": "Follow-up resident surveys showed significantly higher scores in the model/simulation group regarding overall interest in perioperative ultrasound ( P = @ ) as well understanding of the physiologic concepts ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25195059", "label": "conclusions", "text": "A model/simulation-based based lecture series may be more effective in teaching the skills needed to perform a point-of-care ultrasound examination to anesthesiology residents .", "sentence_id": 12}
+{"abstract_id": "24556773", "label": "objective", "text": "Women in academic medicine are not achieving the same career advancement as men , and face unique challenges in managing work and family alongside intense work demands .", "sentence_id": 0}
+{"abstract_id": "24556773", "label": "objective", "text": "The purpose of this study was to investigate how a supportive department/division culture buffered women from the impact of work demands on work-to-family conflict .", "sentence_id": 1}
+{"abstract_id": "24556773", "label": "methods", "text": "As part of a larger intervention trial , the authors collected baseline survey data from @ women assistant professors at the University of Pennsylvania Perelman School of Medicine in @ .", "sentence_id": 2}
+{"abstract_id": "24556773", "label": "methods", "text": "Validated measures of work demands , work-to-family conflict , and a department/division culture were employed .", "sentence_id": 3}
+{"abstract_id": "24556773", "label": "methods", "text": "Pearson correlations and general linear mixed modeling were used to analyze the data .", "sentence_id": 4}
+{"abstract_id": "24556773", "label": "methods", "text": "Authors investigated whether work culture moderated the association between work demands and work-to-family conflict .", "sentence_id": 5}
+{"abstract_id": "24556773", "label": "results", "text": "Heavy work demands were associated with increased levels of work-to-family conflict .", "sentence_id": 6}
+{"abstract_id": "24556773", "label": "results", "text": "There were significant interactions between work demands , work-to-family conflict , and department/division culture .", "sentence_id": 7}
+{"abstract_id": "24556773", "label": "results", "text": "A culture conducive to women 's academic success significantly moderated the effect of work hours on time-based work-to-family conflict and significantly moderated the effect of work overload on strain-based work-to-family conflict .", "sentence_id": 8}
+{"abstract_id": "24556773", "label": "results", "text": "At equivalent levels of work demands , women in more supportive cultures experienced lower levels of work-to-family conflict .", "sentence_id": 9}
+{"abstract_id": "24556773", "label": "conclusions", "text": "The culture of the department/division plays a crucial role in women 's work-to-family conflict and can exacerbate or alleviate the impact of extremely high work demands .", "sentence_id": 10}
+{"abstract_id": "24556773", "label": "conclusions", "text": "This finding leads to important insights about strategies for more effectively supporting the careers of women assistant professors .", "sentence_id": 11}
+{"abstract_id": "25003264", "label": "background", "text": "The addition of glutamine in preoperative drinks may enhance the benefits of carbohydrate alone .", "sentence_id": 0}
+{"abstract_id": "25003264", "label": "objective", "text": "To evaluate the gastric residual volume after the intake of a beverage containing carbohydrate plus glutamine .", "sentence_id": 1}
+{"abstract_id": "25003264", "label": "methods", "text": "Eleven healthy volunteers ( @-@ years-old ) were randomized in a crossover fashion to intake @ mL ( @h before ) and @ mL ( @h before ) of a beverage containing either @ % maltodextrin ( carbohydrate group ) or @ % maltodextrin plus @ g of glutamine ( glutamine group ) in two different moments @ days apart .", "sentence_id": 2}
+{"abstract_id": "25003264", "label": "methods", "text": "Magnetic ressonance was performed to measure the gastric residual volume ( mL ) @ and @ minutes after the last ingestion .", "sentence_id": 3}
+{"abstract_id": "25003264", "label": "results", "text": "Gastric residual volume similar to basal condition was found after @h and @h of the intake of beverages .", "sentence_id": 4}
+{"abstract_id": "25003264", "label": "results", "text": "There was no difference in the mean SD GRV ( mL ) found at @ minutes ( carbohydrate group : @ and glutamine group : @ ) and at @ minutes ( carbohydrate group : @ and glutamine group : @ ) between the two drinks .", "sentence_id": 5}
+{"abstract_id": "25003264", "label": "conclusions", "text": "Gastric emptying is efficient , and occurs in up to two hours after the intake of a beverage containing either carbohydrate alone or carbohydrate associated with glutamine .", "sentence_id": 6}
+{"abstract_id": "25003264", "label": "conclusions", "text": "The addition of glutamine to carbohydrate-enriched drink seems to be safe for the use up to @h before an operation .", "sentence_id": 7}
+{"abstract_id": "25583168", "label": "background", "text": "Little is known about how different antiretrovirals effect inflammation and monocyte activation in human immunodeficiency virus ( HIV ) infection .", "sentence_id": 0}
+{"abstract_id": "25583168", "label": "methods", "text": "We examined plasma specimens obtained during a randomized , double-blinded trial in antiretroviral therapy ( ART ) - naive HIV-infected adults which compared the efficacy of elvitegravir/cobicistat/emtricitabine / tenofovir disoproxil fumarate ( EVG/c/FTC / TDF ) with that of efavirenz/emtricitabine/tenofovir disoproxil fumarate ( EFV/FTC/TDF ) .", "sentence_id": 1}
+{"abstract_id": "25583168", "label": "methods", "text": "From a random sample achieving an HIV type @ RNA load of < @ copies/mL by week @ , changes over @ and @ weeks in levels of biomarkers of monocyte activation ( soluble CD@ -LSB- sCD@ -RSB- and soluble CD@ -LSB- sCD@ -RSB- ) , systemic inflammation ( soluble tumor necrosis factor receptor I -LSB- sTNF-RI -RSB- , interleukin @ -LSB- IL-@ -RSB- , and high-sensitivity C-reactive protein -LSB- hsCRP -RSB- ) , and vascular inflammation ( lipoprotein-associated phospholipase A@ -LSB- Lp-PLA@ -RSB- ) were compared .", "sentence_id": 2}
+{"abstract_id": "25583168", "label": "methods", "text": "Multivariable linear regression was used .", "sentence_id": 3}
+{"abstract_id": "25583168", "label": "results", "text": "A total of @ participants were included .", "sentence_id": 4}
+{"abstract_id": "25583168", "label": "results", "text": "Significant differences favoring EVG/c/FTC / TDF were noted for changes in sCD@ , hsCRP , and Lp-PLA@ levels .", "sentence_id": 5}
+{"abstract_id": "25583168", "label": "results", "text": "Factors independently associated with a larger decrease in the sCD@ level included random assignment to receive EVG/c/FTC / TDF , higher baseline sCD@ level , and larger decreases in hsCRP and sCD@ levels ; factors associated with a larger Lp-PLA@ decrease included higher baseline Lp-PLA@ and IL-@ levels , smaller increases in total cholesterol and triglycerides levels , a larger decrease in the sCD@ level , and a smaller decrease in the sCD@ level .", "sentence_id": 6}
+{"abstract_id": "25583168", "label": "conclusions", "text": "EVG/c/FTC / TDF led to greater decreases in sCD@ , hsCRP , and Lp-PLA@ levels , compared with EFV/FTC/TDF .", "sentence_id": 7}
+{"abstract_id": "25583168", "label": "conclusions", "text": "Randomization group independently predicted the change in sCD@ level , and changes in monocyte activation independently predicted the change in Lp-PLA@ level .", "sentence_id": 8}
+{"abstract_id": "25583168", "label": "conclusions", "text": "There appears to be a more favorable effect of the integrase inhibitor EVG over efavirenz on immune activation , which may affect vascular inflammation .", "sentence_id": 9}
+{"abstract_id": "25398967", "label": "background", "text": "Vitamin D supplementation may be an inexpensive intervention to reduce heart failure ( HF ) incidence .", "sentence_id": 0}
+{"abstract_id": "25398967", "label": "background", "text": "However , there are insufficient data to support this hypothesis .", "sentence_id": 1}
+{"abstract_id": "25398967", "label": "background", "text": "This study evaluates whether vitamin D plus calcium ( CaD ) supplementation is associated with lower rates of HF in postmenopausal women and whether the effects differ between those at high versus low risk for HF .", "sentence_id": 2}
+{"abstract_id": "25398967", "label": "results", "text": "Analyses were restricted to @ @ ( of original @ @ ) women aged @ to @ years old in the Women 's Health Initiative randomized trial of CaD supplementation who were randomized @:@ in a double-blinded fashion to receive @ mg/d of calcium plus @ IU/d of vitamin D@ or placebo .", "sentence_id": 3}
+{"abstract_id": "25398967", "label": "results", "text": "Overall , @ adjudicated incident HF cases ( intervention , @ ; control , @ ) occurred during a median follow-up of @ ( interquartile range , @ ) years .", "sentence_id": 4}
+{"abstract_id": "25398967", "label": "results", "text": "CaD supplementation , compared with placebo , was not associated with reduced HF risk in the overall population , hazard ratio , @ ; P = @ .", "sentence_id": 5}
+{"abstract_id": "25398967", "label": "results", "text": "However , CaD supplementation had differential effects ( P interaction = @ ) in subgroups stratified by baseline risk status of HF defined by the presence ( high risk = @ @ ) or absence ( low risk = @ @ ) of pre-existing HF precursors including coronary heart diseases , diabetes mellitus , or hypertension : @ % ( hazard ratio , @ -LSB- @ % confidence interval , @-@ @ -RSB- ) lower risk of HF in the low-risk versus hazard ratio , @ ; P = @ , in the high-risk subgroups .", "sentence_id": 6}
+{"abstract_id": "25398967", "label": "conclusions", "text": "CaD supplementation did not significantly reduce HF incidence in the overall cohort , however , it was beneficial among postmenopausal women without major HF precursors while of little value in high-risk subgroups .", "sentence_id": 7}
+{"abstract_id": "25398967", "label": "conclusions", "text": "Additional studies are warranted to confirm these findings and investigate the underlying mechanism .", "sentence_id": 8}
+{"abstract_id": "24401928", "label": "background", "text": "Nonpegylated liposomal doxorubicin liposomal doxorubicin , ( Myocet ; Sopherion Therapeutics , Inc Canada , and Cephalon , Europe ) ( NPLD ; Myocet ( ) ) in combination with trastuzumabHerceptin ( ) ( Hoffmann-La Roche ) has shown promising activity and cardiac safety .", "sentence_id": 0}
+{"abstract_id": "24401928", "label": "background", "text": "We conducted a randomized phase III trial of first-line NPLD plus trastuzumab and paclitaxel ( Pharmachemie B.V. ) ( MTP ) versus trastuzumab plus paclitaxel ( TP ) in patients with human epidermal growth factor @ receptor ( HER@ ) - positive metastatic breast cancer .", "sentence_id": 1}
+{"abstract_id": "24401928", "label": "methods", "text": "Patients were randomly assigned to NPLD ( M , @ mg/m ( @ ) every @ weeks for six cycles ) , trastuzumab ( T , @ mg/kg loading dose followed by @ mg/kg weekly ) , and paclitaxel ( P , @ mg/m ( @ ) weekly ) or T + P at the same doses until progression or toxicity .", "sentence_id": 2}
+{"abstract_id": "24401928", "label": "methods", "text": "The primary efficacy outcome was progression-free survival ( PFS ) .", "sentence_id": 3}
+{"abstract_id": "24401928", "label": "results", "text": "One hundred and eighty-one patients were allocated to receive MTP , and @ to TP .", "sentence_id": 4}
+{"abstract_id": "24401928", "label": "results", "text": "Median PFS was @ and @ months with MTP and TP , respectively -LSB- hazard ratio ( HR ) @ ; two-sided P = @ -RSB- .", "sentence_id": 5}
+{"abstract_id": "24401928", "label": "results", "text": "In patients with estrogen receptor ( ER ) - and progesterone receptor ( PR ) - negative tumors , PFS was @ and @ months , respectively -LSB- HR @ ; @ % confidence interval ( CI ) @-@ @ -RSB- .", "sentence_id": 6}
+{"abstract_id": "24401928", "label": "results", "text": "Median overall survival ( OS ) was @ and @ months with MTP and TP , respectively ( HR @ ; two-sided P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24401928", "label": "results", "text": "In ER - and PR-negative tumors , OS was @ and @ months , respectively ( HR @ ; @ % CI @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24401928", "label": "results", "text": "The frequency of adverse events was higher with MTP , but there was no significant difference in cardiac toxicity between treatment arms .", "sentence_id": 9}
+{"abstract_id": "24401928", "label": "conclusions", "text": "The trial failed to demonstrate a significant clinical improvement with the addition of M to TP regimen .", "sentence_id": 10}
+{"abstract_id": "24401928", "label": "conclusions", "text": "The clinical benefit observed in an exploratory analysis in the ER - and PR-negative population deserves consideration for further clinical trials .", "sentence_id": 11}
+{"abstract_id": "24581132", "label": "objective", "text": "To evaluate the efficacy of reflex entropy ( RE ) / state entropy ( SE ) in monitoring the response to nociceptive stimulus during propofol-remifentanil infusion .", "sentence_id": 0}
+{"abstract_id": "24581132", "label": "methods", "text": "After the approval of the hospital ethics committee , sixty American Society of Anesthesiologists ( ASA ) classification @-@ patients , aged @-@ years , receiving the hypogastrium operation undergoing general anesthesia , were randomly allocated to groups A and B with different remifentanil concentrations .", "sentence_id": 1}
+{"abstract_id": "24581132", "label": "methods", "text": "After the concentration of propofol and remifentanil reached balance , tetanic stimulation , intubation , and incision were performed respectively with certain intervals .", "sentence_id": 2}
+{"abstract_id": "24581132", "label": "methods", "text": "RE and SE were monitored during this procedure .", "sentence_id": 3}
+{"abstract_id": "24581132", "label": "results", "text": "Twelve patients were withdrawn from this study due to the use of vasoactive drugs .", "sentence_id": 4}
+{"abstract_id": "24581132", "label": "results", "text": "Finally , there were @ cases in group A and @ cases in group B.", "sentence_id": 5}
+{"abstract_id": "24581132", "label": "results", "text": "The RE and SE were not significantly changed before and after the tetanic stimulation in both groups ( all P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24581132", "label": "results", "text": "Both RE and SE were significantly increased after intubation in group B ( both P < @ ) and after skin incision in both groups ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24581132", "label": "results", "text": "Under the same stimulation , RE and SE showed no significant difference among groups administered with different levels of remifentanil ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24581132", "label": "conclusions", "text": "Under the anesthesia with propofol + remifentanil , nociceptive response may cause the increase of RE and SE .", "sentence_id": 9}
+{"abstract_id": "24581132", "label": "conclusions", "text": "Therefore , RE and SE may be useful parameters for monitoring the nociceptive response during general anaesthesia .", "sentence_id": 10}
+{"abstract_id": "24373326", "label": "objective", "text": "To compare the outcome of deep sclerectomy ( DS ) with and without mitomycin-C ( MMC ) in patients with normal-tension glaucoma ( NTG ) .", "sentence_id": 0}
+{"abstract_id": "24373326", "label": "methods", "text": "We prospectively analysed the results of @ eyes of @ consecutive patients with NTG ( age ; mean SD ; @ @ years ) who underwent DS with a collagen implant .", "sentence_id": 1}
+{"abstract_id": "24373326", "label": "methods", "text": "Patients were randomized to the MMC and non-MMC groups .", "sentence_id": 2}
+{"abstract_id": "24373326", "label": "methods", "text": "Subconjunctival MMC ( @ mg/ml for @ min ) was used intraoperatively in @ of @ eyes .", "sentence_id": 3}
+{"abstract_id": "24373326", "label": "methods", "text": "We defined total success as @ % reduction in intraocular pressure ( IOP ) without medication .", "sentence_id": 4}
+{"abstract_id": "24373326", "label": "methods", "text": "Follow-up time was @ months .", "sentence_id": 5}
+{"abstract_id": "24373326", "label": "results", "text": "The mean preoperative IOP was significantly reduced from @ @ mmHg to @ @ ( p < @ ) in the MMC group after @-month follow-up and from @ @ mmHg to @ @ ( p < @ ) in the non-MMC group .", "sentence_id": 6}
+{"abstract_id": "24373326", "label": "results", "text": "At @ months , the mean IOP was significantly lower in the MMC group ( p = @ ) compared with the non-MMC group .", "sentence_id": 7}
+{"abstract_id": "24373326", "label": "results", "text": "Total success was achieved in @ of @ eyes ( @ % ) in MMC group and in nine of @ eyes ( @ % ) in non-MMC group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24373326", "label": "results", "text": "The number of glaucoma medications was decreased from @ @ to @ @ in MMC group ( p = @ ) and from @ @ to @ @ in non-MMC group ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24373326", "label": "results", "text": "Goniopuncture was performed in seven eyes ( @ % ) in the MMC group , compared with @ eyes ( @ % ) in the non-MMC group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24373326", "label": "results", "text": "IOP < @ mmHg was achieved in seven of @ eyes in the MMC group and in two of @ in the non-MMC group ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24373326", "label": "results", "text": "Complication rate was low , and no difference between groups was evident .", "sentence_id": 12}
+{"abstract_id": "24373326", "label": "conclusions", "text": "Deep sclerectomy seems to be effective and safe in reducing IOP in patients with NTG .", "sentence_id": 13}
+{"abstract_id": "24373326", "label": "conclusions", "text": "Intraoperative use of MMC results in lower postoperative IOP @-month postoperatively without increased rate of complications .", "sentence_id": 14}
+{"abstract_id": "24634346", "label": "objective", "text": "Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training ( IMT ) on aerobic training ( AT ) in patients with chronic heart failure ( CHF ) .", "sentence_id": 0}
+{"abstract_id": "24634346", "label": "results", "text": "Forty-three CHF patients with a mean age of @ years , peak oxygen consumption ( peak VO@ ) @ mL/kg/min , and LVEF @ % were randomized to an AT/IMT group ( n = @ ) or to an AT/SHAM group ( n = @ ) in a @-week exercise programme .", "sentence_id": 1}
+{"abstract_id": "24634346", "label": "results", "text": "AT involved @ min of ergometer training at @-@ % of maximum heart rate , three times a week for both groups .", "sentence_id": 2}
+{"abstract_id": "24634346", "label": "results", "text": "In the AT/IMT group , IMT was performed at @ % of sustained maximal inspiratory pressure ( SPImax ) while in the AT/SHAM group it was performed at @ % of SPImax , using a computer biofeedback trainer for @ min , three times a week .", "sentence_id": 3}
+{"abstract_id": "24634346", "label": "results", "text": "At baseline and at @ months , patients were evaluated for exercise capacity , lung function , inspiratory muscle strength ( PImax ) and work capacity ( SPImax ) , quality of life ( QoL ) , LVEF and LV diameter , dyspnoea , C-reactive protein ( CRP ) , and NT-proBNP .", "sentence_id": 4}
+{"abstract_id": "24634346", "label": "results", "text": "IMT resulted in a significantly higher benefit in SPImax ( P = @ ) , QoL ( P = @ ) , dyspnoea ( P = @ ) , CRP ( P = @ ) , and NT-proBNP ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24634346", "label": "results", "text": "In both AT/IMT and AT/SHAM groups PImax ( P < @ , P = @ ) , peak VO@ ( P = @ , P = @ ) , and LVEF ( P = @ , P = @ ) improved significantly ; however , without an additional benefit for either of the groups .", "sentence_id": 6}
+{"abstract_id": "24634346", "label": "conclusions", "text": "This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF .", "sentence_id": 7}
+{"abstract_id": "24634346", "label": "conclusions", "text": "These findings advocate for application of IMT in cardiac rehabilitation programmes .", "sentence_id": 8}
+{"abstract_id": "25571933", "label": "background", "text": "Anaesthetists may fail to recognize and manage certain rare intraoperative events .", "sentence_id": 0}
+{"abstract_id": "25571933", "label": "background", "text": "Simulation has been shown to be an effective educational adjunct to typical operating room-based education to train for these events .", "sentence_id": 1}
+{"abstract_id": "25571933", "label": "background", "text": "It is yet unclear , however , why simulation has any benefit .", "sentence_id": 2}
+{"abstract_id": "25571933", "label": "background", "text": "We hypothesize that learners who are allowed to manage a scenario independently and allowed to fail , thus causing simulated morbidity , will consequently perform better when re-exposed to a similar scenario .", "sentence_id": 3}
+{"abstract_id": "25571933", "label": "methods", "text": "Using a randomized , controlled , observer-blinded design , @ first-year residents were exposed to an oxygen pipeline contamination scenario , either where patient harm occurred ( independent group , n = @ ) or where a simulated attending anaesthetist intervened to prevent harm ( supervised group , n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25571933", "label": "methods", "text": "Residents were brought back @ months later and exposed to a different scenario ( pipeline contamination ) with the same end point .", "sentence_id": 5}
+{"abstract_id": "25571933", "label": "methods", "text": "Participants ' proper treatment , time to diagnosis , and non-technical skills ( measured using the Anaesthetists ' Non-Technical Skills Checklist , ANTS ) were measured .", "sentence_id": 6}
+{"abstract_id": "25571933", "label": "results", "text": "No participants provided proper treatment in the initial exposure .", "sentence_id": 7}
+{"abstract_id": "25571933", "label": "results", "text": "In the repeat encounter @ months later , @ % in the independent group vs @ % in the supervised group resumed adequate oxygen delivery ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25571933", "label": "results", "text": "The independent group also had better ANTS scores -LSB- median ( interquartile range ) : @ ( @-@ @ ) vs @ ( @-@ ) , P = @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "25571933", "label": "results", "text": "There was no difference in time to treatment if proper management was provided -LSB- @ ( @-@ ) vs @ ( @-@ ) s , P = @ -RSB- .", "sentence_id": 10}
+{"abstract_id": "25571933", "label": "conclusions", "text": "Allowing residents to practise independently in the simulation laboratory , and subsequently , allowing them to fail , can be an important part of simulation-based learning .", "sentence_id": 11}
+{"abstract_id": "25571933", "label": "conclusions", "text": "This is not feasible in real clinical practice but appears to have improved resident performance in this study .", "sentence_id": 12}
+{"abstract_id": "25571933", "label": "conclusions", "text": "The purposeful use of independent practice and its potentially negative outcomes thus sets simulation-based learning apart from traditional operating room learning .", "sentence_id": 13}
+{"abstract_id": "25157013", "label": "objective", "text": "Cardiovascular disease ( CVD ) and underlying atherosclerosis begin in childhood and are related to CVD risk factors .", "sentence_id": 0}
+{"abstract_id": "25157013", "label": "objective", "text": "This study evaluates tools and strategies to enhance adoption of new CVD risk reduction guidelines for children .", "sentence_id": 1}
+{"abstract_id": "25157013", "label": "methods", "text": "Thirty-two practices , recruited and supported by @ primary care research networks , were cluster randomized to a multifaceted controlled intervention .", "sentence_id": 2}
+{"abstract_id": "25157013", "label": "methods", "text": "Practices were compared with guideline-based individual and composite measures for BMI , blood pressure ( BP ) , and tobacco .", "sentence_id": 3}
+{"abstract_id": "25157013", "label": "methods", "text": "Composite measures were constructed by summing the numerators and denominators of individual measures .", "sentence_id": 4}
+{"abstract_id": "25157013", "label": "methods", "text": "Preintervention and postintervention measures were assessed by medical record review of children ages @ to @ years .", "sentence_id": 5}
+{"abstract_id": "25157013", "label": "methods", "text": "Changes in measures ( pre-post and intervention versus control ) were compared .", "sentence_id": 6}
+{"abstract_id": "25157013", "label": "results", "text": "The intervention group BP composite improved by @ % , increasing from @ % to @ % , compared with the control group ( @ % to @ % ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25157013", "label": "results", "text": "Intervention group BP interpretation improved by @ % ( from @ % to @ % ) , compared with the control group ( @ % to @ % ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25157013", "label": "results", "text": "The assessment of tobacco exposure or use for @ - to @-year-olds in the intervention group improved by @ % ( from @ % to @ % ) versus the control group ( @ % to @ % ) ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25157013", "label": "results", "text": "No significant change was seen in the BMI or tobacco composites measures .", "sentence_id": 10}
+{"abstract_id": "25157013", "label": "results", "text": "The overall composite of @ measures improved by @ % ( from @ % to @ % ) for the intervention group versus the control group ( @ % to @ % ) ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25157013", "label": "conclusions", "text": "Significant improvement was demonstrated in the overall composite measure , the composite measure of BP , and tobacco assessment and advice for children aged @ to @ years .", "sentence_id": 12}
+{"abstract_id": "24452810", "label": "objective", "text": "Veliparib ( ABT-@ ) is a potent oral inhibitor of Poly ( ADP-ribose ) polymerase enzyme that is currently in development for the treatment of non-hematologic and hematologic malignancies .", "sentence_id": 0}
+{"abstract_id": "24452810", "label": "objective", "text": "This analysis characterizes the population pharmacokinetics of veliparib , including developing a structural pharmacokinetic model and testing patient demographics and covariates for potential influence on veliparib pharmacokinetics in patients with non-hematologic malignancies .", "sentence_id": 1}
+{"abstract_id": "24452810", "label": "methods", "text": "The analysis dataset included @,@ veliparib concentration values from @ patients with non-hematologic malignancies enrolled in three phase I and one phase II studies .", "sentence_id": 2}
+{"abstract_id": "24452810", "label": "methods", "text": "Population pharmacokinetic modeling was performed using NONMEM .", "sentence_id": 3}
+{"abstract_id": "24452810", "label": "methods", "text": "The likelihood ratio test was used for comparison of nested models , and visual predictive check was employed for model qualification .", "sentence_id": 4}
+{"abstract_id": "24452810", "label": "methods", "text": "Covariates tested included body size measures , creatinine clearance ( CLCR ) , formulation , age , sex , race , liver function tests , and coadministration with temozolomide .", "sentence_id": 5}
+{"abstract_id": "24452810", "label": "results", "text": "A one-compartment model with first-order absorption and elimination adequately described veliparib pharmacokinetics .", "sentence_id": 6}
+{"abstract_id": "24452810", "label": "results", "text": "The final model included fixed effects for CLCR on veliparib oral clearance ( CL/F ) and lean body mass ( LBM ) on volume of distribution ( V d/F ) .", "sentence_id": 7}
+{"abstract_id": "24452810", "label": "results", "text": "CL/F and V d/F were @ L/h ( for a CLCR of @ mL/min ) and @ L ( for an LBM of @ kg ) , respectively .", "sentence_id": 8}
+{"abstract_id": "24452810", "label": "conclusions", "text": "Only LBM and CLCR were found to be determinants of veliparib V d/F and CL/F , respectively .", "sentence_id": 9}
+{"abstract_id": "24452810", "label": "conclusions", "text": "Dosage adjustments of veliparib on the basis of body size , age , sex , race , liver function , and temozolomide coadministration are not necessary in patients with non-hematologic malignancies .", "sentence_id": 10}
+{"abstract_id": "24452810", "label": "conclusions", "text": "This is the first study to characterize the population pharmacokinetics of veliparib , and the developed model will be used to conduct simulations and evaluate veliparib exposure-response relationships .", "sentence_id": 11}
+{"abstract_id": "25516139", "label": "objective", "text": "To determine whether supplementation with vitamin D improves resilience to the adverse effects of earthquakes .", "sentence_id": 0}
+{"abstract_id": "25516139", "label": "methods", "text": "Opportunistic addition to an established randomised double blind placebo controlled trial .", "sentence_id": 1}
+{"abstract_id": "25516139", "label": "methods", "text": "Christchurch , New Zealand , where a prolonged series of catastrophic earthquakes beginning on @ September @ occurred , which caused widespread destruction , fatalities , and extensive psychological damage .", "sentence_id": 2}
+{"abstract_id": "25516139", "label": "methods", "text": "@ healthy adults ( @ women ; @ men ) aged @-@ who were already participating in the vitamin D and acute respiratory infections study ( VIDARIS ) between February @ and November @ .", "sentence_id": 3}
+{"abstract_id": "25516139", "label": "methods", "text": "Participants were randomised to receive an oral dose of either @,@ IU vitamin D@ monthly for two months then @,@ IU monthly ( n = @ ) or placebo ( n = @ ) for a total of @ months .", "sentence_id": 4}
+{"abstract_id": "25516139", "label": "methods", "text": "This is a post hoc analysis from the previously published VIDARIS trial .", "sentence_id": 5}
+{"abstract_id": "25516139", "label": "methods", "text": "The primary endpoint in the current analysis was the self reported effects and overall adverse impact of the Christchurch earthquakes as assessed by questionnaire four months after the most destructive earthquake on @ February @ , which was used as the index event .", "sentence_id": 6}
+{"abstract_id": "25516139", "label": "methods", "text": "The secondary end point was the number of `` psychological '' adverse events that participants reported at their usual monthly appointments as part of the original VIDARIS trial .", "sentence_id": 7}
+{"abstract_id": "25516139", "label": "results", "text": "@ participants completed the earthquake impact questionnaire ( n = @ in the vitamin D group and @ in the placebo group ) .", "sentence_id": 8}
+{"abstract_id": "25516139", "label": "results", "text": "There was no significant difference in the number of self reported adverse effects between those receiving vitamin D supplementation and those receiving placebo .", "sentence_id": 9}
+{"abstract_id": "25516139", "label": "results", "text": "There was also no difference in the overall adverse impact score between treatment groups ( ( @ ) P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25516139", "label": "results", "text": "The exception was that those in the vitamin D group experienced more adverse effects on family relationships ( @ % v @ % ; ( @ ) P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25516139", "label": "results", "text": "The number of psychological adverse events-such as fatigue , stress , anxiety , and insomnia-that participants reported at their usual monthly appointments was significantly higher after the earthquake ( ( @ ) P = @ ) but did not differ between treatment groups .", "sentence_id": 12}
+{"abstract_id": "25516139", "label": "conclusions", "text": "In this trial , vitamin D supplementation did not reduce the adverse impact of earthquakes in healthy adults .", "sentence_id": 13}
+{"abstract_id": "25516139", "label": "conclusions", "text": "Trial registration Australian New Zealand Clinical Trials Registry ( anzctr.org.au ) ACTRN@ .", "sentence_id": 14}
+{"abstract_id": "24297951", "label": "objective", "text": "Cumulative neurotoxicity is a prominent toxicity of oxaliplatin-based therapy .", "sentence_id": 0}
+{"abstract_id": "24297951", "label": "objective", "text": "Intravenous calcium and magnesium have been extensively used to reduce oxaliplatin-induced neurotoxicity .", "sentence_id": 1}
+{"abstract_id": "24297951", "label": "objective", "text": "This trial was designed to definitively test whether calcium/magnesium decreases oxaliplatin-related neurotoxicity .", "sentence_id": 2}
+{"abstract_id": "24297951", "label": "methods", "text": "In all , @ patients with colon cancer undergoing adjuvant therapy with FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) were randomly assigned to intravenous calcium/magnesium before and after oxaliplatin , a placebo before and after , or calcium/magnesium before and placebo after .", "sentence_id": 3}
+{"abstract_id": "24297951", "label": "methods", "text": "The primary end point was cumulative neurotoxicity measured by the sensory scale of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy @ tool .", "sentence_id": 4}
+{"abstract_id": "24297951", "label": "results", "text": "There were no statistically significant neuropathy differences among the study arms as measured by the primary end point or additional measures of neuropathy , including clinician-determined measurement of the time to grade @ neuropathy by using the National Cancer Institute Common Terminology Criteria for Adverse Events scale or an oxaliplatin-specific neuropathy scale .", "sentence_id": 5}
+{"abstract_id": "24297951", "label": "results", "text": "In addition , calcium/magnesium did not substantially decrease oxaliplatin-induced acute neuropathy .", "sentence_id": 6}
+{"abstract_id": "24297951", "label": "conclusions", "text": "This study does not support using calcium/magnesium to protect against oxaliplatin-induced neurotoxicity .", "sentence_id": 7}
+{"abstract_id": "24978428", "label": "objective", "text": "To evaluate the effects of @ mg or @ mg of ranibizumab in eyes with macular telangiectasia type @ without subretinal neovascularization .", "sentence_id": 0}
+{"abstract_id": "24978428", "label": "methods", "text": "Ten eyes were randomized to either @ mg or @ mg ranibizumab group in @ eye only .", "sentence_id": 1}
+{"abstract_id": "24978428", "label": "methods", "text": "Study eye received ranibizumab at baseline and at Months @ and @ .", "sentence_id": 2}
+{"abstract_id": "24978428", "label": "methods", "text": "Injections at Months @ , @ , and @ were at investigator 's discretion .", "sentence_id": 3}
+{"abstract_id": "24978428", "label": "methods", "text": "Participants were followed monthly through @ months with best-corrected visual acuity , fluorescein angiography , and optical coherence tomography .", "sentence_id": 4}
+{"abstract_id": "24978428", "label": "results", "text": "For study eyes at baseline , median best-corrected visual acuity letter score was @ ( @/@ Snellen equivalent ) and central subfield retinal thickness was @ m. Median number of injections was six .", "sentence_id": 5}
+{"abstract_id": "24978428", "label": "results", "text": "Median change in best-corrected visual acuity at Month @ was @ letters ( range : -@ to @ letters ) at both doses in the study eye and @ letters ( range : -@ to @ letters ) in the untreated fellow eye .", "sentence_id": 6}
+{"abstract_id": "24978428", "label": "results", "text": "At Month @ , retinal leakage decreased @ disk area and @ disk area for @ mg and @ mg ranibizumab , respectively .", "sentence_id": 7}
+{"abstract_id": "24978428", "label": "results", "text": "Median change in central subfield retinal thickness was @ m and -@ m for @ mg and @ mg ranibizumab , respectively .", "sentence_id": 8}
+{"abstract_id": "24978428", "label": "conclusions", "text": "Ranibizumab ( @ mg or @ mg ) decreases leakage secondary to macular telangiectasia type @ , but accompanying improvements in best-corrected visual acuity appear similar to improvements in the untreated fellow eye where retinal thickness is relatively unchanged .", "sentence_id": 9}
+{"abstract_id": "25552615", "label": "background", "text": "Patients with transient ischaemic attack ( TIA ) or stroke are at risk for cognitive impairment and dementia .", "sentence_id": 0}
+{"abstract_id": "25552615", "label": "background", "text": "Currently , there is no known effective strategy to prevent this cognitive decline .", "sentence_id": 1}
+{"abstract_id": "25552615", "label": "background", "text": "Increasing evidence exists that physical exercise is beneficial for cognitive function .", "sentence_id": 2}
+{"abstract_id": "25552615", "label": "background", "text": "However , in patients with TIA or stroke who are at risk of cognitive impairment and dementia , only a few trials have been conducted .", "sentence_id": 3}
+{"abstract_id": "25552615", "label": "background", "text": "In this study , we aim to investigate whether a physical exercise programme ( MoveIT ) can prevent cognitive decline in patients in the acute phase after a TIA or minor ischaemic stroke .", "sentence_id": 4}
+{"abstract_id": "25552615", "label": "methods", "text": "A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care .", "sentence_id": 5}
+{"abstract_id": "25552615", "label": "methods", "text": "@ adult patients with a TIA or minor ischaemic stroke less than @ month ago will be randomly allocated to an exercise programme consisting of a @-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the period of @ year or to usual care .", "sentence_id": 6}
+{"abstract_id": "25552615", "label": "methods", "text": "Outcome measures will be assessed at the baseline , and at the @-year and @-year follow-up .", "sentence_id": 7}
+{"abstract_id": "25552615", "label": "methods", "text": "The primary outcome is cognitive functioning measured with the Montreal Cognitive Assessment ( MoCA ) test and with additional neuropsychological tests .", "sentence_id": 8}
+{"abstract_id": "25552615", "label": "methods", "text": "Secondary outcomes include maximal exercise capacity , self-reported physical activity and measures of secondary prevention .", "sentence_id": 9}
+{"abstract_id": "24816689", "label": "objective", "text": "To compare staples with subcuticular sutures for skin closure in emergency Cesarean sections ( CS ) .", "sentence_id": 0}
+{"abstract_id": "24816689", "label": "methods", "text": "One hundred and thirty women ( undergoing emergency CS without previous abdominal delivery ) were randomly assigned to either staples or subcuticular skin closure ( monocryl @-@ ) .", "sentence_id": 1}
+{"abstract_id": "24816689", "label": "methods", "text": "Primary outcome of the study was cosmetic outcome -LSB- as assessed by patient and independent observer : Patient Scar Assessment Scale ( PSAS ) and Observer Scar Assessment Scale ( OSAS ) , respectively -RSB- , @weeks post-operative .", "sentence_id": 2}
+{"abstract_id": "24816689", "label": "methods", "text": "Secondary outcomes were wound complications , operating time , post-operative pain ( visual analogue scale day @ post-operative and patient assessment of pain in scar @weeks post-operative ) , and duration of hospital stay .", "sentence_id": 3}
+{"abstract_id": "24816689", "label": "results", "text": "@ women were available for evaluation of scar @weeks post-operative .", "sentence_id": 4}
+{"abstract_id": "24816689", "label": "results", "text": "Cosmetic result of staples was significantly better than subcuticular sutures ( PSAS and OSAS : p value @ and @ , respectively ) , with significantly lesser duration of surgery ( @ vs. @min : p value @ ) and comparable post-operative pain ( pain on day @ and @weeks post-operatively : p value @ and @ , respectively ) and wound complications ( p value @ ) .", "sentence_id": 5}
+{"abstract_id": "24816689", "label": "results", "text": "However , duration of stay in hospital was increased ( @ vs. @days : p value @ ) .", "sentence_id": 6}
+{"abstract_id": "24816689", "label": "conclusions", "text": "Staples are the method of choice for skin closure in emergency CS as they are significantly better than subcuticular sutures with respect to cosmesis and duration of surgery .", "sentence_id": 7}
+{"abstract_id": "24816689", "label": "conclusions", "text": "Post-operative pain and wound complications are comparable in two groups .", "sentence_id": 8}
+{"abstract_id": "24816689", "label": "conclusions", "text": "However , staples are associated with significantly increased duration of hospital stay .", "sentence_id": 9}
+{"abstract_id": "24816689", "label": "conclusions", "text": "Trial registered in clinical trial registry CTRI : REF/@/@ / @ .", "sentence_id": 10}
+{"abstract_id": "25429720", "label": "background", "text": "Chronic thoracic pain after cardiac surgery is prevalent ( @ to @ % ) and may affect patients ' physical and mental health status .", "sentence_id": 0}
+{"abstract_id": "25429720", "label": "background", "text": "Despite its favorable pharmacokinetic and pharmacodynamic properties , high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and increased requirements for analgesics .", "sentence_id": 1}
+{"abstract_id": "25429720", "label": "background", "text": "Recently , an association between remifentanil use and the incidence of chronic thoracic pain in the long term was also reported .", "sentence_id": 2}
+{"abstract_id": "25429720", "label": "background", "text": "Our objective is to investigate the influence of the intraoperative remifentanil on chronic postoperative pain in a prospective randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "25429720", "label": "methods", "text": "In this prospective , randomized , single-blind clinical trial , all patients ( N = @ ) between @ and @ years undergoing cardiac surgery via sternotomy receive a continuous infusion of propofol together with intermittent intravenous fentanyl at predetermined times perioperatively .", "sentence_id": 4}
+{"abstract_id": "25429720", "label": "methods", "text": "Patients are randomized to receive either an additional continuous infusion of remifentanil ( @ g ( -@ ) kgIBW ( -@ ) min ( -@ ) ) or additional fentanyl ( @ to @ g ) as needed during surgery.The primary end point is the prevalence of chronic thoracic pain @ months after surgery .", "sentence_id": 5}
+{"abstract_id": "25429720", "label": "methods", "text": "Secondary end points include acute postoperative pain ; postoperative analgesic use ; chronic thoracic pain @ and @ months after surgery ; quality of life ( SF-@ ) at @ , @ and @ months after surgery ; work productivity ; and use of health care .", "sentence_id": 6}
+{"abstract_id": "25429720", "label": "methods", "text": "In addition , thermal detection and pain thresholds are measured preoperatively , @ days after surgery and @ months after surgery using quantitative sensory testing ( QST ) .", "sentence_id": 7}
+{"abstract_id": "25429720", "label": "methods", "text": "Finally , the influence of several genetic variances on the different outcomes will be measured .", "sentence_id": 8}
+{"abstract_id": "25429720", "label": "conclusions", "text": "Chronic thoracic pain is prevalent after cardiac surgery , and research is needed to minimize the risk of chronic persistent postoperative pain , which is an invalidating , long-term complication of surgery .", "sentence_id": 9}
+{"abstract_id": "25429720", "label": "conclusions", "text": "The objective of this trial is to determine the influence of perioperative remifentanil on long-term pain outcomes for cardiac patients in a prospective randomized trial .", "sentence_id": 10}
+{"abstract_id": "25429720", "label": "conclusions", "text": "The results may be used to optimize perioperative analgesia techniques and , thereby , improve quality of life after cardiac surgery .", "sentence_id": 11}
+{"abstract_id": "25042932", "label": "objective", "text": "To develop a reliable and safe laryngeal nerve conduction technique and to obtain consistent parameters as normal reference values .", "sentence_id": 0}
+{"abstract_id": "25042932", "label": "methods", "text": "A prospective single-arm study .", "sentence_id": 1}
+{"abstract_id": "25042932", "label": "methods", "text": "A nerve conduction test was performed on the contralateral normal side in @ patients with unilateral vocal fold palsy .", "sentence_id": 2}
+{"abstract_id": "25042932", "label": "methods", "text": "The recording was performed in the intact thyroarytenoid muscle using a monopolar needle .", "sentence_id": 3}
+{"abstract_id": "25042932", "label": "methods", "text": "The electrical stimulation using a @-mm monopolar needle was applied @ cm below the lower margin of the cricoid cartilage , just lateral to the trachea and medial to the carotid artery , and its intensity was gradually increased until the amplitude of the electrical response reached the maximum level .", "sentence_id": 4}
+{"abstract_id": "25042932", "label": "methods", "text": "The latency of the evoked muscle response was acquired at the first evoked waveform deflection from the baseline .", "sentence_id": 5}
+{"abstract_id": "25042932", "label": "results", "text": "The average latency of the recurrent laryngeal nerves was @ ms. The latencies showed normal distribution according to the quantile-quantile plot and Kolmogorov-Smirnov test ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25042932", "label": "results", "text": "There was no significant difference in latencies between the right and left recurrent laryngeal nerves .", "sentence_id": 7}
+{"abstract_id": "25042932", "label": "results", "text": "Anthropometric factors including height and weight did not show any correlation with the latencies .", "sentence_id": 8}
+{"abstract_id": "25042932", "label": "conclusions", "text": "We developed a reliable and safe laryngeal nerve conduction technique and obtained normal reference values for the recurrent laryngeal nerve conduction study .", "sentence_id": 9}
+{"abstract_id": "25042932", "label": "conclusions", "text": "This laryngeal nerve conduction study can be an additional tool for detecting recurrent laryngeal nerve injury if it is performed in combination with the conventional laryngeal electromyography .", "sentence_id": 10}
+{"abstract_id": "25012422", "label": "objective", "text": "Because increased dopamine neurotransmission occurs with most antidepressants , and because antipsychotics cause behavioural supersensitivity to dopamine , short-term low-dose antipsychotic treatment was tested on depressed patients with an expectation of clinical improvement in the supersensitive phase following drug withdrawal .", "sentence_id": 0}
+{"abstract_id": "25012422", "label": "methods", "text": "This was a randomized , double-blind , placebo-controlled study of @ patients who met criteria for DSM-IV ( ) Major Depressive Disorder , were in a Major Depressive Episode , and had a Hamilton Depression Rating Scale ( HAMD ) rating of @ .", "sentence_id": 1}
+{"abstract_id": "25012422", "label": "methods", "text": "Half the participants received @ mg oral haloperidol each day for @ days , after which they received placebo daily for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25012422", "label": "methods", "text": "The other half received placebo throughout the trial .", "sentence_id": 3}
+{"abstract_id": "25012422", "label": "results", "text": "One week after stopping the medication , the HAMD ratings of the drug-treated patients fell by @ points , as compared to a reduction of @ points in the placebo-treated patients , when comparing visits @ and @ .", "sentence_id": 4}
+{"abstract_id": "25012422", "label": "results", "text": "There was no such difference when comparing visits @ and @ .", "sentence_id": 5}
+{"abstract_id": "25012422", "label": "results", "text": "The differences were not significant , but indicated a trend .", "sentence_id": 6}
+{"abstract_id": "25012422", "label": "results", "text": "One week after the medication was stopped , the Clinical Global Index fell @ units for the medication-treated patients , compared to @ units for the placebo group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25012422", "label": "results", "text": "The regimen was well tolerated .", "sentence_id": 8}
+{"abstract_id": "25012422", "label": "conclusions", "text": "Seven days of an ultra-low dose of @ mg haloperidol , followed by withdrawal of haloperidol , resulted in clinical depression improvement greater than placebo and significantly decreased psychomotor retardation , consistent with haloperidol-induced behavioural supersensitivity to dopamine .", "sentence_id": 9}
+{"abstract_id": "25012422", "label": "conclusions", "text": "The sample was small .", "sentence_id": 10}
+{"abstract_id": "25012422", "label": "conclusions", "text": "More patients are needed in a future study .", "sentence_id": 11}
+{"abstract_id": "25261241", "label": "objective", "text": "To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used .", "sentence_id": 0}
+{"abstract_id": "25261241", "label": "methods", "text": "Randomized prospective clinical trial .", "sentence_id": 1}
+{"abstract_id": "25261241", "label": "methods", "text": "The Infant Aphakia Treatment Study randomized @ patients with unilateral cataracts at age @-@ months to either primary intraocular lens ( IOL ) or contact lens correction .", "sentence_id": 2}
+{"abstract_id": "25261241", "label": "methods", "text": "At @ years of age a masked examiner assessed stereopsis on these patients using @ different tests : ( @ ) Frisby ; ( @ ) Randot Preschool ; and ( @ ) Titmus Fly .", "sentence_id": 3}
+{"abstract_id": "25261241", "label": "results", "text": "Twenty-eight patients ( @ % ) had a positive response to at least @ of the stereopsis tests .", "sentence_id": 4}
+{"abstract_id": "25261241", "label": "results", "text": "There was no statistically significant difference in stereopsis between the @ treatment groups : Frisby ( contact lens , @ -LSB- @ % -RSB- ; IOL , @ -LSB- @ % -RSB- ; P = @ ) , Randot ( contact lens , @ -LSB- @ % -RSB- ; IOL , @ -LSB- @ % -RSB- ; P = @ ) , or Titmus ( contact lens , @ -LSB- @ % -RSB- ; IOL , @ -LSB- @ % -RSB- ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25261241", "label": "results", "text": "The median age at surgery for patients with stereopsis was younger than for those without stereopsis ( @ vs @ months ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25261241", "label": "results", "text": "The median visual acuity for patients with stereopsis was better than for those without stereopsis ( @/@ vs @/@ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25261241", "label": "conclusions", "text": "The type of optical correction did not influence stereopsis outcomes .", "sentence_id": 8}
+{"abstract_id": "25261241", "label": "conclusions", "text": "However , @ other factors did : age at surgery and visual acuity in the treated eye at age @ years .", "sentence_id": 9}
+{"abstract_id": "25261241", "label": "conclusions", "text": "Early surgery for unilateral congenital cataract and the presence of visual acuity better than or equal to @/@ appear to be more important than the type of initial optical correction used for the development of stereopsis .", "sentence_id": 10}
+{"abstract_id": "24875781", "label": "background", "text": "Although the rate of bleeding among patients with atrial fibrillation ( AF ) taking novel oral anticoagulants in randomized controlled trials is described , the rate of bleeding with `` real-world '' use is uncertain .", "sentence_id": 0}
+{"abstract_id": "24875781", "label": "methods", "text": "We conducted a retrospective electronic medical record interrogation and subsequent chart review among patients within Intermountain Healthcare between October @ and November @ .", "sentence_id": 1}
+{"abstract_id": "24875781", "label": "methods", "text": "Patients were included if they had a diagnosis of AF and were receiving either dabigatran or rivaroxaban .", "sentence_id": 2}
+{"abstract_id": "24875781", "label": "methods", "text": "Rates of major bleeding were calculated .", "sentence_id": 3}
+{"abstract_id": "24875781", "label": "results", "text": "Among @ patients , @ ( @ % ) experienced major bleeding ( @ % confidence interval -LSB- CI -RSB- @-@ @ ) , @ ( @ % ) experienced intracranial hemorrhage ( @ % CI @-@ @ ) , and @ ( @ % ) experienced fatal bleeding .", "sentence_id": 4}
+{"abstract_id": "24875781", "label": "results", "text": "Of the @ patients experiencing a major bleed , @ ( @ % ) would have been excluded from the Randomized Evaluation of Long-Term Anticoagulation Therapy ( RE-LY ) and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for prevention of Stroke and Embolism Trial in Atrial Fibrillation ( ROCKET AF ) clinical trials .", "sentence_id": 5}
+{"abstract_id": "24875781", "label": "conclusions", "text": "We observed a rate of major bleeding similar to that reported in randomized clinical trials among patients with AF prescribed dabigatran or rivaroxaban .", "sentence_id": 6}
+{"abstract_id": "25409911", "label": "background", "text": "Psychosocial problems are highly prevalent among Dutch adolescents .", "sentence_id": 0}
+{"abstract_id": "25409911", "label": "background", "text": "We have conducted a trial to test whether offering chat-based consultations could be of added value within the context of Dutch Youth Health Care .", "sentence_id": 1}
+{"abstract_id": "25409911", "label": "background", "text": "This trial was ended prematurely because of recruitment issues .", "sentence_id": 2}
+{"abstract_id": "25409911", "label": "background", "text": "The aim of this study is to learn from this failed trial and to provide more insight into non-participation .", "sentence_id": 3}
+{"abstract_id": "25409911", "label": "background", "text": "Sources of data were non-participation forms , oral clarification , patient records , telephone interviews with adolescents that declined to participate , and a questionnaire-based process evaluation among nurses .", "sentence_id": 4}
+{"abstract_id": "25409911", "label": "results", "text": "Non-participation appears to be a multi-factorial problem .", "sentence_id": 5}
+{"abstract_id": "25409911", "label": "results", "text": "Of those @ adolescents eligible to participate , the majority ( n = @ , @ % ) declined to do so .", "sentence_id": 6}
+{"abstract_id": "25409911", "label": "results", "text": "Two-third of those ( n = @ ) also refused usual care , which might be indicative of not wanting help and/or experiencing problems and the validity of the assessment instrument .", "sentence_id": 7}
+{"abstract_id": "25409911", "label": "results", "text": "The other one-third ( n = @ ) did enrol in usual care and indicated other reasons for non-participation , such as a preference for face-to-face consultations , the extensive information that was provided , and not liking the idea of being randomized .", "sentence_id": 8}
+{"abstract_id": "25409911", "label": "conclusions", "text": "This study shows that even if a trial fails , we can learn about the challenges of recruiting adolescents in intervention trials .", "sentence_id": 9}
+{"abstract_id": "25046949", "label": "objective", "text": "To investigate the therapeutic effect of Yiqi Huaju Recipe ( YHR ) combined with routine therapy on the blood pressure , the blood pressure variability and other cardiovascular risk factors in hypertension patients complicated with metabolic syndrome ( MetS ) .", "sentence_id": 0}
+{"abstract_id": "25046949", "label": "methods", "text": "Totally @ hypertension patients complicated with MetS were recruited in this study and randomly assigned to the treatment group ( @ cases , treated with basic routine treatment + YHR ) and the control group ( @ cases , treated with basic routine treatment + placebo ) .", "sentence_id": 1}
+{"abstract_id": "25046949", "label": "methods", "text": "The treatment course was @ weeks .", "sentence_id": 2}
+{"abstract_id": "25046949", "label": "methods", "text": "Detected were parameters such as @-h ambulatory blood pressure monitoring ( ABPM ) , body mass index ( BMI ) , waist circumference ( WC ) , waist to hip ratio ( WHR ) , homeostatic model assessment for insulin resistance ( HOMA-IR ) , fasting glycosylated hemoglobin A@c ( HbA@c ) , fasting plasma glucose ( FPG ) , @ h postprandial plasma glucose ( @ h PPG ) , fasting plasma insulin ( FPI ) , serum lipid , etc. .", "sentence_id": 3}
+{"abstract_id": "25046949", "label": "results", "text": "The anthropometric parameters and plasma glucose levels ( except HbAlc ) were obviously lowered after treatment than before treatment in the treatment group ( P < @ , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25046949", "label": "results", "text": "Besides , better effects were obtained in the WC , WHR , @ h PPG , FPI and HOMA-IR ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25046949", "label": "results", "text": "The average blood pressure amplitude , the blood pressure variability , and blood pressure load at any time point were more obviously improved in the two groups after treatment than before treatment ( P < @ , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25046949", "label": "results", "text": "Besides , partial indices were better in the treatment group than in the control group ( P < @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25046949", "label": "conclusions", "text": "YHR combined with routine therapy exhibited better effect on reducing the blood pressure amplitude , the blood pressure variability , and the blood pressure load in hypertension patients complicated with MetS .", "sentence_id": 8}
+{"abstract_id": "25046949", "label": "conclusions", "text": "It could also effectively decrease the risk of other vascular disease .", "sentence_id": 9}
+{"abstract_id": "24980066", "label": "objective", "text": "Whether there are age-related changes in slow wave activity ( SWA ) rise time , a marker of homeostatic sleep drive , is unknown .", "sentence_id": 0}
+{"abstract_id": "24980066", "label": "objective", "text": "Additionally , although sleep medication use is highest among older adults , the quantitative electroencephalographic ( EEG ) profile of the most commonly prescribed sleep medication , zolpidem , in older adults is also unknown .", "sentence_id": 1}
+{"abstract_id": "24980066", "label": "objective", "text": "We therefore quantified age-related and regional brain differences in sleep EEG with and without zolpidem .", "sentence_id": 2}
+{"abstract_id": "24980066", "label": "methods", "text": "Thirteen healthy young adults aged @ years and @ healthy older adults aged @ years participated in a randomized , double-blind , within-subject study that compared placebo to @mg zolpidem .", "sentence_id": 3}
+{"abstract_id": "24980066", "label": "results", "text": "Older adults showed a smaller rise in SWA and zolpidem increased age-related differences in SWA rise time such that age differences were observed earlier after latency to persistent sleep .", "sentence_id": 4}
+{"abstract_id": "24980066", "label": "results", "text": "Age-related differences in EEG power differed by brain region .", "sentence_id": 5}
+{"abstract_id": "24980066", "label": "results", "text": "Older , but not young , adults showed zolpidem-dependent reductions in theta and alpha frequencies .", "sentence_id": 6}
+{"abstract_id": "24980066", "label": "results", "text": "Zolpidem decreased stage @ in older adults and did not alter other age-related sleep architecture parameters .", "sentence_id": 7}
+{"abstract_id": "24980066", "label": "conclusions", "text": "SWA findings provide additional support for reduced homeostatic sleep drive or reduced ability to respond to sleep drive with age .", "sentence_id": 8}
+{"abstract_id": "24980066", "label": "conclusions", "text": "Consequences of reduced power in theta and alpha frequencies in older adults remain to be elucidated .", "sentence_id": 9}
+{"abstract_id": "24722497", "label": "objective", "text": "To assess the long-term effects of dietary interventions on glycemic control , need for diabetes medications , and remission of type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24722497", "label": "methods", "text": "Originally , in a two-arm trial design , overweight , middle-aged men and women with newly diagnosed type @ diabetes were randomized to a low-carbohydrate Mediterranean diet ( LCMD ; n = @ ) or a low-fat diet ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24722497", "label": "methods", "text": "After @ years , participants who were still free of diabetes medications were further followed up until the primary end point ( need of a diabetic drug ) ; remission of diabetes ( partial or complete ) and changes in weight , glycemic control , and cardiovascular risk factors were also evaluated .", "sentence_id": 2}
+{"abstract_id": "24722497", "label": "results", "text": "The primary end point was reached in all participants after a total follow-up of @ years in the low-fat group and @ years in the LCMD group ; median survival time was @ years ( @ % CI @-@ @ ) and @ years ( @-@ @ ) , respectively .", "sentence_id": 3}
+{"abstract_id": "24722497", "label": "results", "text": "The unadjusted hazard ratio for the overall follow-up was @ ( @-@ @ ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24722497", "label": "results", "text": "LCMD participants were more likely to experience any remission ( partial or complete ) , with a prevalence of @ % ( @-@ @ % ) during the first year and @ % ( @-@ @ % ) during year @ compared with @ % ( @-@ @ % ) at year @ and @ % at year @ in the low-fat diet group .", "sentence_id": 5}
+{"abstract_id": "24722497", "label": "conclusions", "text": "In patients with newly diagnosed type @ diabetes , an LCMD resulted in a greater reduction of HbA@c levels , higher rate of diabetes remission , and delayed need for diabetes medication compared with a low-fat diet .", "sentence_id": 6}
+{"abstract_id": "25313586", "label": "objective", "text": "Many sub-Saharan African countries report high postpartum loss to follow-up of mother-baby pairs .", "sentence_id": 0}
+{"abstract_id": "25313586", "label": "objective", "text": "We aimed to determine whether interactive text messages improved rates of clinic attendance and early infant HIV testing in the Nyanza region of Kenya .", "sentence_id": 1}
+{"abstract_id": "25313586", "label": "methods", "text": "Parallel-group , unblinded , randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "25313586", "label": "methods", "text": "HIV-positive pregnant women at least @ years old and enrolled in the prevention of mother-to-child transmission of HIV programme were randomized to receive either text messages ( SMS group , n = @ ) or usual care ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25313586", "label": "methods", "text": "Messages were developed using formative focus group research informed by constructs of the Health Belief Model .", "sentence_id": 4}
+{"abstract_id": "25313586", "label": "methods", "text": "The SMS group received up to eight text messages before delivery ( depending on gestational age ) , and six messages postpartum .", "sentence_id": 5}
+{"abstract_id": "25313586", "label": "methods", "text": "Primary outcomes included maternal postpartum clinic attendance and virological infant HIV testing by @ weeks postpartum .", "sentence_id": 6}
+{"abstract_id": "25313586", "label": "methods", "text": "The primary analyses were intention-to-treat .", "sentence_id": 7}
+{"abstract_id": "25313586", "label": "results", "text": "Of the @ enrolled women , @ ( @ % ) had final outcome information .", "sentence_id": 8}
+{"abstract_id": "25313586", "label": "results", "text": "In the SMS group , @ of @ ( @ % ) women attended a maternal postpartum clinic compared to @ of @ ( @ % ) in the control group ( relative risk @ , @ % confidence interval @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25313586", "label": "results", "text": "HIV testing within @ weeks was performed in @ of @ ( @ % ) infants in the SMS group compared to @ of @ ( @ % ) in the control group ( relative risk @ , @ % confidence interval @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25313586", "label": "conclusions", "text": "Text messaging significantly improved maternal postpartum visit attendance , but overall return rates for these visits remained low .", "sentence_id": 11}
+{"abstract_id": "25313586", "label": "conclusions", "text": "In contrast , high rates of early infant HIV testing were achieved in both arms , with significantly higher testing rates in the SMS compared to the control infants .", "sentence_id": 12}
+{"abstract_id": "24432673", "label": "objective", "text": "To evaluate the clinical effectiveness and safety of Fangfeng Tongsheng Granule ( FTG ) in the treatment of upper respiratory infection ( superficial cold and interior heat syndrome , exterior and interior excess syndrome ) .", "sentence_id": 0}
+{"abstract_id": "24432673", "label": "methods", "text": "A randomized , double-blinded , multi-centered , placebo-parallel-controlled clinical trial was adopted .", "sentence_id": 1}
+{"abstract_id": "24432673", "label": "methods", "text": "Totally @ patients were enrolled and assigned to two groups , @ patients in the treatment group and @ patients in the control group .", "sentence_id": 2}
+{"abstract_id": "24432673", "label": "methods", "text": "Those in the treatment group took FTG at the daily dose of @ g , twice per day , the therapeutic course being @ days .", "sentence_id": 3}
+{"abstract_id": "24432673", "label": "methods", "text": "Those with axillary temperature more than @ degrees C took one more time before medication .", "sentence_id": 4}
+{"abstract_id": "24432673", "label": "methods", "text": "Those in the control group took simulated agent granules the same dose and dosage as the treatment group .", "sentence_id": 5}
+{"abstract_id": "24432673", "label": "methods", "text": "The effect of Chinese medical syndrome ( ECMS ) , the rate of temperature-dropping-to-normal ( RT ) , the time of temperature-dropping-to-normal ( TT ) , the curative effect of single symptom ( CESS ) and adverse reactions were observed .", "sentence_id": 6}
+{"abstract_id": "24432673", "label": "results", "text": "Totally @ completed the trial in the treatment group and @ in the control group .", "sentence_id": 7}
+{"abstract_id": "24432673", "label": "results", "text": "In the treatment group , the cured-effective rate was @ % ( @ / @ ) , the total effective rate was @ % ( @/@ ) , the ECMS score decreased by @ + / - @ , while they were @ % ( @/@ ) , @ % ( @/@ ) , and @ + / - @ , respectively in the control group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24432673", "label": "results", "text": "The RT was @ % ( @/@ ) in the treatment group and @ % ( @/@ ) in the control group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24432673", "label": "results", "text": "The TT in the treatment group was superior to that of the control group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24432673", "label": "results", "text": "As for CESS , all of the three primary symptoms and nine secondary symptoms were improved more obviously in the treatment group than in the control group .", "sentence_id": 11}
+{"abstract_id": "24432673", "label": "results", "text": "The integral decreased obviously , showing statistical difference ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24432673", "label": "results", "text": "The decrease was more obvious in the treatment group than in the control group ( P < @ ) .", "sentence_id": 13}
+{"abstract_id": "24432673", "label": "results", "text": "There was no adverse event related to FTG .", "sentence_id": 14}
+{"abstract_id": "24432673", "label": "conclusions", "text": "FTG was effective and safe in treating upper respiratory infection ( superficial cold and interior heat syndrome , exterior and interior excess syndrome ) .", "sentence_id": 15}
+{"abstract_id": "25239479", "label": "background", "text": "The Modifications of Diet in Renal Disease ( MDRD ) and Chronic Kidney Disease Epidemiology Collaboration ( CKD-EPI ) are @ equations commonly used to estimate glomerular filtration rate ( eGFR ) .", "sentence_id": 0}
+{"abstract_id": "25239479", "label": "background", "text": "The predictive performance offered by these equations , particularly in relation to clinical outcomes in elderly hypertensive patients , is not clear .", "sentence_id": 1}
+{"abstract_id": "25239479", "label": "methods", "text": "The Second Australian National Blood Pressure Study cohort was used to investigate the predictive performance of these @ equations for long-term outcomes ( median @ years ) in elderly treated hypertensive patients .", "sentence_id": 2}
+{"abstract_id": "25239479", "label": "methods", "text": "Both equations were used to calculate eGFR in @,@ patients aged @ years and classified as having chronic kidney disease ( CKD ) or no CKD ( eGFR @ml/min/@ @ m@ ) .", "sentence_id": 3}
+{"abstract_id": "25239479", "label": "results", "text": "More patients were classified as having no CKD using the CKD-EPI equation compared with the MDRD equation ( @ % vs. @ % ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25239479", "label": "results", "text": "Both equations performed similarly in risk prediction of all-cause and cardiovascular mortality with decreased eGFR , except for patients with baseline eGFR of @-@ml / min/@ @ m@ , where the CKD-EPI equation predicted higher risk of all-cause mortality compared with those with no CKD .", "sentence_id": 5}
+{"abstract_id": "25239479", "label": "results", "text": "However , the magnitude of difference in risk prediction was too small to be clinically meaningful .", "sentence_id": 6}
+{"abstract_id": "25239479", "label": "results", "text": "Both equations showed similar predictive performance .", "sentence_id": 7}
+{"abstract_id": "25239479", "label": "results", "text": "However , we observed longer survival and no higher risk in those who were reclassified as having no CKD using the CKD-EPI equation , but these patients were classified earlier as having CKD using the MDRD equation .", "sentence_id": 8}
+{"abstract_id": "25239479", "label": "conclusions", "text": "There was no clinically relevant difference in predictive performance for long-term survival by eGFR calculated using either of these equations in this elderly hypertensive population .", "sentence_id": 9}
+{"abstract_id": "25405390", "label": "background", "text": "Ischemic mitral regurgitation is associated with increased mortality and morbidity .", "sentence_id": 0}
+{"abstract_id": "25405390", "label": "background", "text": "For surgical patients with moderate regurgitation , the benefits of adding mitral-valve repair to coronary-artery bypass grafting ( CABG ) are uncertain .", "sentence_id": 1}
+{"abstract_id": "25405390", "label": "methods", "text": "We randomly assigned @ patients with moderate ischemic mitral regurgitation to CABG alone or CABG plus mitral-valve repair ( combined procedure ) .", "sentence_id": 2}
+{"abstract_id": "25405390", "label": "methods", "text": "The primary end point was the left ventricular end-systolic volume index ( LVESVI ) , a measure of left ventricular remodeling , at @ year .", "sentence_id": 3}
+{"abstract_id": "25405390", "label": "methods", "text": "This end point was assessed with the use of a Wilcoxon rank-sum test in which deaths were categorized as the lowest LVESVI rank .", "sentence_id": 4}
+{"abstract_id": "25405390", "label": "results", "text": "At @ year , the mean LVESVI among surviving patients was @ ml per square meter of body-surface area in the CABG-alone group and @ ml per square meter in the combined-procedure group ( mean change from baseline , -@ and -@ ml per square meter , respectively ) .", "sentence_id": 5}
+{"abstract_id": "25405390", "label": "results", "text": "The rate of death was @ % in the combined-procedure group and @ % in the CABG-alone group ( hazard ratio with mitral-valve repair , @ ; @ % confidence interval , @ to @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25405390", "label": "results", "text": "The rank-based assessment of LVESVI at @ year ( incorporating deaths ) showed no significant between-group difference ( z score , @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25405390", "label": "results", "text": "The addition of mitral-valve repair was associated with a longer bypass time ( P < @ ) , a longer hospital stay after surgery ( P = @ ) , and more neurologic events ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25405390", "label": "results", "text": "Moderate or severe mitral regurgitation was less common in the combined-procedure group than in the CABG-alone group ( @ % vs. @ % , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25405390", "label": "results", "text": "There were no significant between-group differences in major adverse cardiac or cerebrovascular events , deaths , readmissions , functional status , or quality of life at @ year .", "sentence_id": 10}
+{"abstract_id": "25405390", "label": "conclusions", "text": "In patients with moderate ischemic mitral regurgitation , the addition of mitral-valve repair to CABG did not result in a higher degree of left ventricular reverse remodeling .", "sentence_id": 11}
+{"abstract_id": "25405390", "label": "conclusions", "text": "Mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation but an increased number of untoward events .", "sentence_id": 12}
+{"abstract_id": "25405390", "label": "conclusions", "text": "Thus , at @ year , this trial did not show a clinically meaningful advantage of adding mitral-valve repair to CABG .", "sentence_id": 13}
+{"abstract_id": "25405390", "label": "conclusions", "text": "Longer-term follow-up may determine whether the lower prevalence of mitral regurgitation translates into a net clinical benefit .", "sentence_id": 14}
+{"abstract_id": "25405390", "label": "conclusions", "text": "( Funded by the National Institutes of Health and the Canadian Institutes of Health Research ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 15}
+{"abstract_id": "25422247", "label": "objective", "text": "To investigate the effects of stellate ganglion block ( SGB ) on the peri-operative vasomotor cytokine content and intrapulmonary shunt in patients with esophagus cancer who underwent thoracotomy .", "sentence_id": 0}
+{"abstract_id": "25422247", "label": "methods", "text": "Forty patients undergoing elective resection of esophageal cancer patients who had I ~ II American Society of Anesthesiologist ( ASA ) were randomly divided into total intravenous anesthesia group ( group N , n = @ ) and total intravenous anesthesia combined with SGB group ( group S , n = @ , @ mL/kg @ % lidocaine was used for SGB @ min before induction ) .", "sentence_id": 1}
+{"abstract_id": "25422247", "label": "methods", "text": "Heart rate ( HR ) , mean arterial pressure ( MAP ) , central venous pressure ( CVP ) , mean pulmonary arterial pressure ( MPAP ) and continuous cardiac output ( CCO ) were continuously monitored .", "sentence_id": 2}
+{"abstract_id": "25422247", "label": "methods", "text": "The blood from internal jugular vein was drawn respectively before induction ( T@ ) , and @ min ( T@ ) , @ min ( T@ ) and @ min ( T@ ) after one-lung ventilation ( OLV ) , and @ min ( T@ ) after two-lung ventilation .", "sentence_id": 3}
+{"abstract_id": "25422247", "label": "methods", "text": "The contents of plasma endothelin ( ET ) , nitric oxide ( NO ) and calcitonin gene-related peptide ( CGRP ) were detected with enzyme linked immunosorbent assay ( ELISA ) .", "sentence_id": 4}
+{"abstract_id": "25422247", "label": "methods", "text": "Meanwhile , arterial and mixed venous blood samples were collected for determination of blood gas and calculation of intrapulmonary shunt fraction ( Qs/Qt ) .", "sentence_id": 5}
+{"abstract_id": "25422247", "label": "results", "text": "During OLV , ET contents were increased significantly in two groups ( P < @ ) , and no significant difference was presented ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "25422247", "label": "results", "text": "NO content in group S was obviously higher than in group N at T@ ( P < @ ) , whereas CGRP content in group N was markedly lower than in group S at each time point ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25422247", "label": "results", "text": "Qs/Qt was significantly increased in both groups after OLV , but there was no statistical significant regarding the Qs/Qt at each time point between two groups .", "sentence_id": 8}
+{"abstract_id": "25422247", "label": "conclusions", "text": "Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy , and has little effect on intrapulmonary shunt at the time of OLV .", "sentence_id": 9}
+{"abstract_id": "25482145", "label": "background", "text": "Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma .", "sentence_id": 0}
+{"abstract_id": "25482145", "label": "background", "text": "The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase @ and @ study in relapsed multiple myeloma .", "sentence_id": 1}
+{"abstract_id": "25482145", "label": "methods", "text": "We randomly assigned @ patients with relapsed multiple myeloma to carfilzomib with lenalidomide and dexamethasone ( carfilzomib group ) or lenalidomide and dexamethasone alone ( control group ) .", "sentence_id": 2}
+{"abstract_id": "25482145", "label": "methods", "text": "The primary end point was progression-free survival .", "sentence_id": 3}
+{"abstract_id": "25482145", "label": "results", "text": "Progression-free survival was significantly improved with carfilzomib ( median , @ months , vs. @ months in the control group ; hazard ratio for progression or death , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25482145", "label": "results", "text": "The median overall survival was not reached in either group at the interim analysis .", "sentence_id": 5}
+{"abstract_id": "25482145", "label": "results", "text": "The Kaplan-Meier @-month overall survival rates were @ % and @ % in the carfilzomib and control groups , respectively ( hazard ratio for death , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25482145", "label": "results", "text": "The rates of overall response ( partial response or better ) were @ % and @ % in the carfilzomib and control groups , respectively ( P < @ ; @ % and @ % of patients in the respective groups had a complete response or better ; @ % and @ % had a stringent complete response ) .", "sentence_id": 7}
+{"abstract_id": "25482145", "label": "results", "text": "Adverse events of grade @ or higher were reported in @ % and @ % of patients in the carfilzomib and control groups , respectively ; @ % and @ % of patients discontinued treatment owing to adverse events .", "sentence_id": 8}
+{"abstract_id": "25482145", "label": "results", "text": "Patients in the carfilzomib group reported superior health-related quality of life .", "sentence_id": 9}
+{"abstract_id": "25482145", "label": "conclusions", "text": "In patients with relapsed multiple myeloma , the addition of carfilzomib to lenalidomide and dexamethasone resulted in significantly improved progression-free survival at the interim analysis and had a favorable risk-benefit profile .", "sentence_id": 10}
+{"abstract_id": "25482145", "label": "conclusions", "text": "( Funded by Onyx Pharmaceuticals ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "25363108", "label": "objective", "text": "One of the most important challenges in public health is to improve the quality of life in elders .", "sentence_id": 0}
+{"abstract_id": "25363108", "label": "objective", "text": "Aging may cause various disorders such as disabilities , high risk conditions and some chronic disease .", "sentence_id": 1}
+{"abstract_id": "25363108", "label": "objective", "text": "In this study the effect of educational intervention based on precede-proceed on quality of life in elders was examined .", "sentence_id": 2}
+{"abstract_id": "25363108", "label": "methods", "text": "This semi experimental study was carried out on @ elders over @ years in Zahedan that were randomly selected by multi-stage sampling method and divided in to control and intervention groups .", "sentence_id": 3}
+{"abstract_id": "25363108", "label": "methods", "text": "Data collection tool was a triploid questionnaire that included demographic data , questions of precede-proceed constructs and SF-@ questionnaire .", "sentence_id": 4}
+{"abstract_id": "25363108", "label": "methods", "text": "The validity and reliability of questionnaire confirmed by experts and Cranach 's Alpha coefficient ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25363108", "label": "methods", "text": "After primary data collecting , educational intervention was performed and after nine months data was collected again and analyzed in spss @ soft-ware using descriptive and analytical statistics .", "sentence_id": 6}
+{"abstract_id": "25363108", "label": "results", "text": "The results showed that mean score of quality of life in participants was low and more than @ % of them had a mean score less than @ % .", "sentence_id": 7}
+{"abstract_id": "25363108", "label": "results", "text": "After intervention the mean score of quality of life only in experimental group significantly increased from @ to @ .", "sentence_id": 8}
+{"abstract_id": "25363108", "label": "results", "text": "Behavior and self-rated health were the strongest predictors for quality of life in this study .", "sentence_id": 9}
+{"abstract_id": "25363108", "label": "conclusions", "text": "Implementation educational intervention based on precedes-proceed model can improve quality of life in elders .", "sentence_id": 10}
+{"abstract_id": "25363108", "label": "conclusions", "text": "Elderly women and older elderly individuals compared with elderly men and younger elderly should be considering as an important risk factor for reducing HRQOL .", "sentence_id": 11}
+{"abstract_id": "24559095", "label": "background", "text": "Yes-associated protein ( YAP@ ) is frequently reported to function as an oncogene in many types of cancer , but in breast cancer results remain controversial .", "sentence_id": 0}
+{"abstract_id": "24559095", "label": "background", "text": "We set out to clarify the role of YAP@ in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP@ in vitro and studying its role in response to the widely used anti-estrogen tamoxifen .", "sentence_id": 1}
+{"abstract_id": "24559095", "label": "methods", "text": "YAP@ protein intensity was scored as absent , weak , intermediate or strong in two primary breast cancer cohorts ( n = @ and n = @ ) and mRNA expression of YAP@ was evaluated in a gene expression dataset ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24559095", "label": "methods", "text": "Recurrence-free survival was analysed using the log-rank test and Cox multivariate analysis was used to test for independence .", "sentence_id": 3}
+{"abstract_id": "24559095", "label": "methods", "text": "WST-@ assay was employed to measure cell viability and a luciferase ERE ( estrogen responsive element ) construct was used to study the effect of tamoxifen , following downregulation of YAP@ using siRNAs .", "sentence_id": 4}
+{"abstract_id": "24559095", "label": "results", "text": "In the ER + ( Estrogen Receptor positive ) subgroup of the randomised cohort , YAP@ expression was inversely correlated to histological grade and proliferation ( p = @ and p = @ , respectively ) whereas in the ER - ( Estrogen Receptor negative ) subgroup YAP@ expression correlated positively to proliferation ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24559095", "label": "results", "text": "Notably , low YAP@ mRNA was independently associated with decreased recurrence-free survival in the gene expression dataset , specifically for the luminal A subgroup ( p < @ ) which includes low proliferating tumours of lower grade , usually associated with a good prognosis .", "sentence_id": 6}
+{"abstract_id": "24559095", "label": "results", "text": "This subgroup specificity led us to hypothesize that YAP@ may be important for response to endocrine therapies , such as tamoxifen , extensively used for luminal A breast cancers .", "sentence_id": 7}
+{"abstract_id": "24559095", "label": "results", "text": "In a tamoxifen randomised patient material , absent YAP@ protein expression was associated with impaired tamoxifen response which was significant upon interaction analysis ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24559095", "label": "results", "text": "YAP@ downregulation resulted in increased progesterone receptor ( PgR ) expression and a delayed and weaker tamoxifen in support of the clinical data .", "sentence_id": 9}
+{"abstract_id": "24559095", "label": "conclusions", "text": "Decreased YAP@ expression is an independent prognostic factor for recurrence in the less aggressive luminal A breast cancer subgroup , likely due to the decreased tamoxifen sensitivity conferred by YAP@ downregulation .", "sentence_id": 10}
+{"abstract_id": "24996973", "label": "background", "text": "Clinical validation of laboratory toothbrushing tests has important advantages .", "sentence_id": 0}
+{"abstract_id": "24996973", "label": "background", "text": "It was , therefore , the aim to demonstrate correlation of tooth cleaning efficiency of a new robot brushing simulation technique with clinical plaque removal .", "sentence_id": 1}
+{"abstract_id": "24996973", "label": "methods", "text": "Clinical programme : @ subjects received dental cleaning prior to @-day-plaque-regrowth-interval .", "sentence_id": 2}
+{"abstract_id": "24996973", "label": "methods", "text": "Plaque was stained , photographically documented and scored using planimetrical index .", "sentence_id": 3}
+{"abstract_id": "24996973", "label": "methods", "text": "Subjects brushed teeth @-@ with three techniques ( horizontal , rotating , vertical ) , each for @s buccally and for @s orally in @ consecutive intervals .", "sentence_id": 4}
+{"abstract_id": "24996973", "label": "methods", "text": "The force was calibrated , the brushing technique was video supported .", "sentence_id": 5}
+{"abstract_id": "24996973", "label": "methods", "text": "Two different brushes were randomly assigned to the subject .", "sentence_id": 6}
+{"abstract_id": "24996973", "label": "methods", "text": "Robot programme : Clinical brushing programmes were transfered to a @-axis-robot .", "sentence_id": 7}
+{"abstract_id": "24996973", "label": "methods", "text": "Artificial teeth @-@ were covered with plaque-simulating substrate .", "sentence_id": 8}
+{"abstract_id": "24996973", "label": "methods", "text": "All brushing techniques were repeated @ times , results were scored according to clinical planimetry .", "sentence_id": 9}
+{"abstract_id": "24996973", "label": "methods", "text": "All data underwent statistical analysis by t-test , U-test and multivariate analysis .", "sentence_id": 10}
+{"abstract_id": "24996973", "label": "results", "text": "The individual clinical cleaning patterns are well reproduced by the robot programmes .", "sentence_id": 11}
+{"abstract_id": "24996973", "label": "results", "text": "Differences in plaque removal are statistically significant for the two brushes , reproduced in clinical and robot data .", "sentence_id": 12}
+{"abstract_id": "24996973", "label": "results", "text": "Multivariate analysis confirms the higher cleaning efficiency for anterior teeth and for the buccal sites .", "sentence_id": 13}
+{"abstract_id": "24996973", "label": "conclusions", "text": "The robot tooth brushing simulation programme showed good correlation with clinically standardized tooth brushing.This new robot brushing simulation programme can be used for rapid , reproducible laboratory testing of tooth cleaning .", "sentence_id": 14}
+{"abstract_id": "24401159", "label": "background", "text": "Patients surviving stroke but who have significant impairment of function in the affected arm are at more risk of developing pain , stiffness and contractures .", "sentence_id": 0}
+{"abstract_id": "24401159", "label": "background", "text": "The abnormal muscle activity , associated with post-stroke spasticity , is thought to be causally associated with the development of these complications .", "sentence_id": 1}
+{"abstract_id": "24401159", "label": "background", "text": "Treatment of spasticity is currently delayed until a patient develops signs of these complications .", "sentence_id": 2}
+{"abstract_id": "24401159", "label": "methods", "text": "This protocol is for a phase II study that aims to identify whether using OnabotulinumtoxinA ( BoNT-A ) in combination with physiotherapy early post stroke when initial abnormal muscle activity is neurophysiologically identified can prevent loss of range at joints and improve functional outcomes.The trial uses a screening phase to identify which people are appropriate to be included in a double blind randomised placebo-controlled trial .", "sentence_id": 3}
+{"abstract_id": "24401159", "label": "methods", "text": "All patients admitted to Sandwell and West Birmingham NHS Trust Hospitals with a diagnosis of stroke will be screened to identify functional activity in the arm .", "sentence_id": 4}
+{"abstract_id": "24401159", "label": "methods", "text": "Those who have no function will be appropriate for further screening .", "sentence_id": 5}
+{"abstract_id": "24401159", "label": "methods", "text": "Patients who are screened and have abnormal muscle activity identified on EMG will be given electrical stimulation to forearm extensors for @ months and randomised to have either injections of BoNT-A or normal saline .", "sentence_id": 6}
+{"abstract_id": "24401159", "label": "methods", "text": "The primary outcome measure is the action research arm test - a measure of arm function .", "sentence_id": 7}
+{"abstract_id": "24401159", "label": "methods", "text": "Further measures include spasticity , stiffness , muscle strength and fatigue as well as measures of quality of life , participation and caregiver strain .", "sentence_id": 8}
+{"abstract_id": "25335326", "label": "objective", "text": "To observe the efficacy and safety of Qizhi Jiangtang Capsule ( QJC ) in treating stage @b diabetic kidney disease ( DKD ) patients with macroalbuminuria .", "sentence_id": 0}
+{"abstract_id": "25335326", "label": "methods", "text": "Patients who conformed to the diagnostic criteria of stage @b DKD were randomly assigned to two groups according to random digital table , the experiment group and the control group , @ in each group .", "sentence_id": 1}
+{"abstract_id": "25335326", "label": "methods", "text": "All patients received a two-week elution period , and then were treated with basic Western therapy .", "sentence_id": 2}
+{"abstract_id": "25335326", "label": "methods", "text": "Patients in the experiment group took QJC , @ pills per time , @ times a day , while those in the control group took Valsartan Capsule @ mg each time , once daily .", "sentence_id": 3}
+{"abstract_id": "25335326", "label": "methods", "text": "The observation period of follow-ups was limited within @ months , and the time points were set as the baseline , @st month , @rd month , and @th month .", "sentence_id": 4}
+{"abstract_id": "25335326", "label": "methods", "text": "Systolic blood pressure ( SBP ) , diastolic blood pressure ( DBS ) , @ h urine protein quantitative ( @ h UPQ ) , plasma albumin ( ALB ) , and serum creatinine ( SCr ) were detected and recorded , and estimated glomerular filtration rate ( eGFR ) was calculated .", "sentence_id": 5}
+{"abstract_id": "25335326", "label": "methods", "text": "The occurrence of hypoglycemic reaction , coagulation disorder , gastrointestinal tract reaction , allergy , hyperkalemia , doubling of creatinine , and overall adverse events were observed and recorded at same time .", "sentence_id": 6}
+{"abstract_id": "25335326", "label": "results", "text": "Finally @ patients in the experiment group and @ patients in the control group were effectively included .", "sentence_id": 7}
+{"abstract_id": "25335326", "label": "results", "text": "Compared with the baseline level , SBP and DBS obviously decreased in the control group at month @ of treatment ( P < @ ) , and more significantly decreased at month @ of treatment ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25335326", "label": "results", "text": "SBP at month @ , @ , and @ of follow-ups ; DBS at month @ of follow-ups was lower in the control group than in the experiment group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25335326", "label": "results", "text": "At month @ , @ , and @ of follow-ups , @ h UPQ of the experiment group was significantly lower than the baseline level ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25335326", "label": "results", "text": "It was also significantly lower than the level of the control group at the same time point ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25335326", "label": "results", "text": "There was no significant difference in @ h UPQ at month @ , @ , and @ of follow-ups between the control group and the baseline level ( P > @ ) .", "sentence_id": 12}
+{"abstract_id": "25335326", "label": "results", "text": "ALB of the experiment group showed an increasing trend .", "sentence_id": 13}
+{"abstract_id": "25335326", "label": "results", "text": "It was significantly higher than the baseline level at month @ ( P < @ ) , which was also higher than that of the control group at same period ( P < @ ) .", "sentence_id": 14}
+{"abstract_id": "25335326", "label": "results", "text": "There was no significant difference in the ALB level in the control group ( P > @ ) .", "sentence_id": 15}
+{"abstract_id": "25335326", "label": "results", "text": "SCr of two groups showed an increasing trend .", "sentence_id": 16}
+{"abstract_id": "25335326", "label": "results", "text": "SCr of the experiment group was significantly higher at month @ , @ , and @ follow-ups than the baseline level ( P < @ ) .", "sentence_id": 17}
+{"abstract_id": "25335326", "label": "results", "text": "But the increment of SCr was higher in the control group than in the experimental group , and obviously higher than the baseline levels ( P < @ ) .", "sentence_id": 18}
+{"abstract_id": "25335326", "label": "results", "text": "eGFR of both groups showed a decreasing trend .", "sentence_id": 19}
+{"abstract_id": "25335326", "label": "results", "text": "The decrement was higher in the control group than in the experimental group ( P < @ ) .", "sentence_id": 20}
+{"abstract_id": "25335326", "label": "results", "text": "The proportion of progression of renal functions at month @ , @ , and @ of follow-ups in the experimental group was @ % ( @ case ) , @ % ( @ cases ) , and @ % ( @ cases ) , while they were @ % ( @ cases ) , @ % ( @ cases ) , and @ % ( @ cases ) in the control group .", "sentence_id": 21}
+{"abstract_id": "25335326", "label": "results", "text": "There was no statistical difference in the proportion of progression of renal functions between the two groups at month @ and @ of follow-ups ( P < @ ) .", "sentence_id": 22}
+{"abstract_id": "25335326", "label": "results", "text": "There was no statistical difference in the incidence of adverse reactions between two groups ( P > @ ) .", "sentence_id": 23}
+{"abstract_id": "25335326", "label": "conclusions", "text": "QJC could effectively reduce urinary protein of patients with stage @b DKD , and delay the progression of renal functions .", "sentence_id": 24}
+{"abstract_id": "24687430", "label": "objective", "text": "To investigate and compare several quantification methods of myocardial perfusion measurements , paying special attention to the relation between the techniques and the required measurement duration .", "sentence_id": 0}
+{"abstract_id": "24687430", "label": "methods", "text": "Seven patients underwent contrast-enhanced rest and stress cardiac perfusion measurements at @T .", "sentence_id": 1}
+{"abstract_id": "24687430", "label": "methods", "text": "Three slices were acquired in each patient and were divided into @ segments , leading to @ rest and stress data curves , which were analyzed using various tracer kinetic models as well as a model-free deconvolution .", "sentence_id": 2}
+{"abstract_id": "24687430", "label": "methods", "text": "Plasma flow , plasma volume , and myocardial perfusion reserve were analyzed for the complete acquisition as well as for the first pass data only .", "sentence_id": 3}
+{"abstract_id": "24687430", "label": "results", "text": "Deconvolution analysis yielded stable results for both rest and stress analysis , while Fermi and one compartment models agree well for first pass data ( rest measurements only ) and prolonged data acquisition ( stress measurements only ) .", "sentence_id": 4}
+{"abstract_id": "24687430", "label": "results", "text": "More complex models do not yield satisfactory results for the short measurement times investigated in this study .", "sentence_id": 5}
+{"abstract_id": "24687430", "label": "conclusions", "text": "When performing MRI-based quantification of myocardial perfusion , care must be taken that the method used is appropriate for the time frame under investigation .", "sentence_id": 6}
+{"abstract_id": "24687430", "label": "conclusions", "text": "When a numerical deconvolution is used instead of tracer kinetic models , more stable results are obtained .", "sentence_id": 7}
+{"abstract_id": "24399554", "label": "objective", "text": "Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence .", "sentence_id": 0}
+{"abstract_id": "24399554", "label": "objective", "text": "To determine efficacy and safety of varenicline and bupropion sustained-release ( SR ; combination therapy ) compared with varenicline ( monotherapy ) in cigarette smokers .", "sentence_id": 1}
+{"abstract_id": "24399554", "label": "methods", "text": "Randomized , blinded , placebo-controlled multicenter clinical trial with a @-week treatment period and follow-up through week @ conducted between October @ and April @ at @ midwestern clinical research sites .", "sentence_id": 2}
+{"abstract_id": "24399554", "label": "methods", "text": "Five hundred six adult ( @ years ) cigarette smokers were randomly assigned and @ ( @ % ) completed the study .", "sentence_id": 3}
+{"abstract_id": "24399554", "label": "methods", "text": "Twelve weeks of varenicline and bupropion SR or varenicline and placebo .", "sentence_id": 4}
+{"abstract_id": "24399554", "label": "methods", "text": "Primary outcome was abstinence rates at week @ , defined as prolonged ( no smoking from @ weeks after the target quit date ) abstinence and @-day point-prevalence ( no smoking past @ days ) abstinence .", "sentence_id": 5}
+{"abstract_id": "24399554", "label": "methods", "text": "Secondary outcomes were prolonged and point-prevalence smoking abstinence rates at weeks @ and @ .", "sentence_id": 6}
+{"abstract_id": "24399554", "label": "methods", "text": "Outcomes were biochemically confirmed .", "sentence_id": 7}
+{"abstract_id": "24399554", "label": "results", "text": "At @ weeks , @ % of the combination therapy group achieved prolonged smoking abstinence and @ % achieved @-day point-prevalence smoking abstinence compared with @ % and @ % in varenicline monotherapy ( odds ratio -LSB- OR -RSB- , @ ; @ % CI , @-@ @ ; P = @ and OR , @ ; @ % CI , @-@ @ ; P = @ , respectively ) .", "sentence_id": 8}
+{"abstract_id": "24399554", "label": "results", "text": "At @ weeks , @ % of the combination therapy group achieved prolonged and @ % achieved @-day point-prevalence smoking abstinence compared with @ % and @ % in varenicline monotherapy ( OR , @ ; @ % CI , @-@ @ ; P = @ and OR , @ ; @ % CI , @-@ @ ; P = @ , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24399554", "label": "results", "text": "At @ weeks , @ % of the combination therapy group achieved prolonged and @ % achieved @-day point-prevalence smoking abstinence compared with @ % and @ % in varenicline monotherapy ( OR , @ ; @ % CI , @-@ @ ; P = @ and OR , @ ; @ % CI , @-@ @ ; P = @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "24399554", "label": "results", "text": "Participants receiving combination therapy reported more anxiety ( @ % vs @ % ; P = @ ) and depressive symptoms ( @ % vs @ % ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24399554", "label": "conclusions", "text": "Among cigarette smokers , combined use of varenicline and bupropion , compared with varenicline alone , increased prolonged abstinence but not @-day point prevalence at @ and @ weeks .", "sentence_id": 12}
+{"abstract_id": "24399554", "label": "conclusions", "text": "Neither outcome was significantly different at @ weeks .", "sentence_id": 13}
+{"abstract_id": "24399554", "label": "conclusions", "text": "Further research is required to determine the role of combination therapy in smoking cessation .", "sentence_id": 14}
+{"abstract_id": "24684734", "label": "objective", "text": "To study the efficacy of transdermal clonidine in the treatment of severe refractory hyperemesis gravidarum ( HG ) , the most severe illness of pregnancy .", "sentence_id": 0}
+{"abstract_id": "24684734", "label": "methods", "text": "The study had a randomised , double - blind , placebo-controlled , cross-over design ( RCT ) .", "sentence_id": 1}
+{"abstract_id": "24684734", "label": "methods", "text": "Single tertiary referral hospital after admission of patients .", "sentence_id": 2}
+{"abstract_id": "24684734", "label": "methods", "text": "Twelve women of gestational age @-@ weeks and a major grade of HG clinical severity who were unresponsive to standard antiemetic treatment .", "sentence_id": 3}
+{"abstract_id": "24684734", "label": "methods", "text": "The patients were randomly treated with and without the active drug ( @ mg patch ) for two consecutive periods of @ days .", "sentence_id": 4}
+{"abstract_id": "24684734", "label": "methods", "text": "The patients were allocated to a random list to receive first placebo and then active drug or the other way round .", "sentence_id": 5}
+{"abstract_id": "24684734", "label": "methods", "text": "Other antiemetic drugs were administered on a scheduled or as-needed basis .", "sentence_id": 6}
+{"abstract_id": "24684734", "label": "methods", "text": "All patients received intravenous hydration and thiamine supplementation .", "sentence_id": 7}
+{"abstract_id": "24684734", "label": "methods", "text": "Pregnancy Unique Quantification of Emesis ( PUQE ) and visual analog scale ( VAS ) clinical scores , positive morning urine ketonuria , number of doses of standard antiemetic drugs required , and number of days off intravenous therapy were compared in the two periods .", "sentence_id": 8}
+{"abstract_id": "24684734", "label": "results", "text": "Transdermal clonidine led to a significantly greater improvement compared with placebo of the primary ( PUQE score P = @ CI @-@ @ ; VAS score P = @ CI @-@ @ ) and secondary outcome measures .", "sentence_id": 9}
+{"abstract_id": "24684734", "label": "results", "text": "A reduction of blood pressure was reported for systolic @ mmHg P = @ and diastolic @ mmHg P = @ .", "sentence_id": 10}
+{"abstract_id": "24684734", "label": "conclusions", "text": "This preliminary RCT demonstrates the efficacy of transdermal clonidine in the treatment of severe HG , leading to a significant reduction of symptoms and reducing the need for other supportive measures and medications .", "sentence_id": 11}
+{"abstract_id": "24720885", "label": "background", "text": "Maternal obesity and gestational diabetes mellitus ( GDM ) may independently influence offspring fat mass and metabolic disease susceptibility .", "sentence_id": 0}
+{"abstract_id": "24720885", "label": "background", "text": "In this pilot study , body composition and fat distribution in offspring from obese women with and without GDM and lean women were assessed within the @st year of life , and maternal and newborn plasma factors were related to offspring adipose tissue distribution .", "sentence_id": 1}
+{"abstract_id": "24720885", "label": "methods", "text": "Serum and plasma samples from pregnant obese women with ( n = @ ) or without ( n = @ ) GDM and normoglycemic lean women ( n = @ ) at @rd trimester and offspring cord plasma were used for analyzing lipid profiles , insulin and adipokine levels .", "sentence_id": 2}
+{"abstract_id": "24720885", "label": "methods", "text": "At week-@ and @ , month-@ and year-@ , offspring anthropometrics and skinfold thickness ( SFT ) were measured and abdominal subcutaneous ( SCA ) and preperitoneal adipose tissue ( PPA ) were determined by ultrasonography .", "sentence_id": 3}
+{"abstract_id": "24720885", "label": "results", "text": "Cord insulin was significantly increased in the GDM group , whereas levels of cord leptin , total and high molecular weight ( HMW ) adiponectin were similar between the groups .", "sentence_id": 4}
+{"abstract_id": "24720885", "label": "results", "text": "Neonates of the GDM group showed significantly higher SFT and fat mass until week-@ and significantly increased SCA at week-@ compared to the lean group that persisted as strong trend at week-@ .", "sentence_id": 5}
+{"abstract_id": "24720885", "label": "results", "text": "Interestingly , PPA in neonates of the GDM group was significantly elevated at week-@ compared to both the lean and obese group .", "sentence_id": 6}
+{"abstract_id": "24720885", "label": "results", "text": "At month-@ and year-@ , significant differences in adipose tissue growth between the groups were not observed .", "sentence_id": 7}
+{"abstract_id": "24720885", "label": "results", "text": "Multiple linear regression analyses revealed that cord insulin levels are independently related to neonatal PPA that showed significant relation to PPA development at year-@ .", "sentence_id": 8}
+{"abstract_id": "24720885", "label": "results", "text": "Maternal fasted C-peptide and HMW adiponectin levels at @rd trimester emerged to be determinants for PPA at week-@ .", "sentence_id": 9}
+{"abstract_id": "24720885", "label": "conclusions", "text": "Maternal pregravid obesity combined with GDM leads to newborn hyperinsulinemia and increased offspring fat mass until week-@ , whereas pregravid obesity without GDM does not .", "sentence_id": 10}
+{"abstract_id": "24720885", "label": "conclusions", "text": "This strongly suggests the pivotal role of GDM in the adverse offspring outcome .", "sentence_id": 11}
+{"abstract_id": "24720885", "label": "conclusions", "text": "Maternal C-peptide and HMW adiponectin levels in pregnancy emerge to be predictive for elevated PPA in newborns and might be indicative for the obesity risk at later life .", "sentence_id": 12}
+{"abstract_id": "24720885", "label": "conclusions", "text": "Altogether , the findings from our pilot study warrant evaluation in long-term studies .", "sentence_id": 13}
+{"abstract_id": "25399274", "label": "objective", "text": "While effective in preventing stroke in patients with atrial fibrillation ( AF ) , warfarin is limited by a narrow therapeutic profile , a need for lifelong coagulation monitoring , and multiple drug and diet interactions .", "sentence_id": 0}
+{"abstract_id": "25399274", "label": "objective", "text": "To determine whether a local strategy of mechanical left atrial appendage ( LAA ) closure was noninferior to warfarin .", "sentence_id": 1}
+{"abstract_id": "25399274", "label": "methods", "text": "PROTECT AF was a multicenter , randomized ( @:@ ) , unblinded , Bayesian-designed study conducted at @ hospitals of @ patients with nonvalvular AF and at least @ additional stroke risk factor ( CHADS@ score @ ) .", "sentence_id": 2}
+{"abstract_id": "25399274", "label": "methods", "text": "Enrollment occurred between February @ and June @ and included @-year follow-up through October @ .", "sentence_id": 3}
+{"abstract_id": "25399274", "label": "methods", "text": "Noninferiority required a posterior probability greater than @ % and superiority a probability of @ % or greater ; the noninferiority margin was a rate ratio of @ comparing event rates between treatment groups .", "sentence_id": 4}
+{"abstract_id": "25399274", "label": "methods", "text": "Left atrial appendage closure with the device ( n = @ ) or warfarin ( n = @ ; target international normalized ratio , @-@ ) .", "sentence_id": 5}
+{"abstract_id": "25399274", "label": "methods", "text": "A composite efficacy end point including stroke , systemic embolism , and cardiovascular/unexplained death , analyzed by intention-to-treat .", "sentence_id": 6}
+{"abstract_id": "25399274", "label": "results", "text": "At a mean ( SD ) follow-up of @ ( @ ) years ( @ patient-years ) , there were @ events among @ patients ( @ % ) in the device group for a primary event rate of @ events per @ patient-years , compared with @ events among @ patients ( @ % ) for a primary event rate of @ events per @ patient-years with warfarin ( rate ratio , @ ; @ % credible interval , @-@ @ ) , meeting prespecified criteria for both noninferiority ( posterior probability , > @ % ) and superiority ( posterior probability , @ % ) .", "sentence_id": 7}
+{"abstract_id": "25399274", "label": "results", "text": "Patients in the device group demonstrated lower rates of both cardiovascular mortality ( @ events per @ patient-years for the device group -LSB- @/@ patients , @ % -RSB- vs @ events per @ patient-years with warfarin -LSB- @/@ patients , @ % -RSB- ; hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @-@ @ ; P = @ ) and all-cause mortality ( @ events per @ patient-years for the device group -LSB- @/@ patients , @ % -RSB- vs @ events per @ patient-years with warfarin -LSB- @/@ patients , @ % -RSB- ; HR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25399274", "label": "conclusions", "text": "After @ years of follow-up among patients with nonvalvular AF at elevated risk for stroke , percutaneous LAA closure met criteria for both noninferiority and superiority , compared with warfarin , for preventing the combined outcome of stroke , systemic embolism , and cardiovascular death , as well as superiority for cardiovascular and all-cause mortality .", "sentence_id": 9}
+{"abstract_id": "25758270", "label": "background", "text": "Despite great reduction of in-stent restenosis , first-generation drug-eluting stents ( DESs ) have increased the risk of late stent thrombosis due to delayed endothelialization .", "sentence_id": 0}
+{"abstract_id": "25758270", "label": "background", "text": "Arsenic trioxide , a natural substance that could inhibit cell proliferation and induce cell apoptosis , seems to be a promising surrogate of sirolimus to improve DES performance .", "sentence_id": 1}
+{"abstract_id": "25758270", "label": "background", "text": "This randomized controlled trial was to evaluate the efficacy and safety of a novel arsenic trioxide-eluting stent ( AES ) , compared with traditional sirolimus-eluting stent ( SES ) .", "sentence_id": 2}
+{"abstract_id": "25758270", "label": "methods", "text": "Patients with symptoms of angina pectoris were enrolled and randomized to AES or SES group .", "sentence_id": 3}
+{"abstract_id": "25758270", "label": "methods", "text": "The primary endpoint was target vessel failure ( TVF ) , and the second endpoint includes rates of all-cause death , cardiac death or myocardial infarction , target lesion revascularization ( TLR ) by telephone visit and late luminal loss ( LLL ) at @-month by angiographic follow-up .", "sentence_id": 4}
+{"abstract_id": "25758270", "label": "results", "text": "From July @ to @ , @ patients were enrolled and randomized @:@ to receive either AES or SES .", "sentence_id": 5}
+{"abstract_id": "25758270", "label": "results", "text": "At @ years of follow-up , TVF rate was similar between AES and SES group ( @ % vs. @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25758270", "label": "results", "text": "Frequency of all-cause death was significantly lower in AES group ( @ vs. @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25758270", "label": "results", "text": "There was no significant difference between AES and SES in frequency of TLR and in-stent restenosis , but greater in-stent LLL was observed for AES group ( @ @ mm vs. @ @ mm , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25758270", "label": "conclusions", "text": "After @ years of follow-up , AES demonstrated comparable efficacy and safety to SES for the treatment of de novo coronary artery lesions .", "sentence_id": 9}
+{"abstract_id": "24608069", "label": "background", "text": "Raltegravir is an HIV-@ integrase inhibitor approved for use in adults , children and infants @ weeks of age .", "sentence_id": 0}
+{"abstract_id": "24608069", "label": "background", "text": "As alternatives to the original film-coated tablet , a chewable ethylcellulose ( EC ) tablet and oral granules for suspension ( GFS ) have been developed for use in children .", "sentence_id": 1}
+{"abstract_id": "24608069", "label": "background", "text": "The purpose of this study was to evaluate these formulations in adults prior to use in paediatric studies .", "sentence_id": 2}
+{"abstract_id": "24608069", "label": "methods", "text": "This open-label , @-period , randomized , crossover study investigated the safety , tolerability and pharmacokinetics of raltegravir paediatric formulations and the effect of a high-fat meal on EC tablet pharmacokinetics in healthy adults .", "sentence_id": 3}
+{"abstract_id": "24608069", "label": "methods", "text": "In a balanced , crossover design ( with a @-day washout between treatments ) , @ subjects received one @ mg film-coated tablet ( fasted ) , four @ mg EC tablets ( fasted ) , one @ mg GFS dose ( fasted ) and four @ mg EC tablets ( after a high-fat meal ) .", "sentence_id": 4}
+{"abstract_id": "24608069", "label": "results", "text": "AUC@ - and Cmax were @-fold and @-fold higher for GFS and @-fold and @-fold higher for EC versus film-coated tablets .", "sentence_id": 5}
+{"abstract_id": "24608069", "label": "results", "text": "The geometric mean C@h values for the GFS formulation ( @ nM ) and the EC tablet ( @ nM ) were similar to that of the film-coated tablet ( @ nM ) .", "sentence_id": 6}
+{"abstract_id": "24608069", "label": "results", "text": "Administration with a high-fat meal increased C@h , decreased Cmax and delayed Tmax for the EC tablet , but did not affect AUC@ - .", "sentence_id": 7}
+{"abstract_id": "24608069", "label": "results", "text": "There were no serious adverse events ( AEs ) and no discontinuations due to drug-related clinical or laboratory AEs .", "sentence_id": 8}
+{"abstract_id": "24608069", "label": "conclusions", "text": "Both paediatric formulations demonstrate moderately higher AUC@ - and Cmax , and similar C@h compared with the film-coated tablet .", "sentence_id": 9}
+{"abstract_id": "24608069", "label": "conclusions", "text": "These data support the use of raltegravir GFS and EC formulations in paediatric studies .", "sentence_id": 10}
+{"abstract_id": "24840756", "label": "objective", "text": "To determine the effect of neonatal caffeine treatment on rates of developmental coordination disorder ( DCD ) .", "sentence_id": 0}
+{"abstract_id": "24840756", "label": "methods", "text": "Children in the Caffeine for Apnea of Prematurity trial were assessed for motor performance ( Movement Assessment Battery for Children -LSB- MABC -RSB- ) , clinical signs of cerebral palsy , and Full-Scale IQ at @ years of age by staff who were unaware of the children 's treatment group .", "sentence_id": 1}
+{"abstract_id": "24840756", "label": "methods", "text": "DCD was defined as MABC < @th percentile in children with a Full-Scale IQ > @ who did not have a diagnosis of cerebral palsy .", "sentence_id": 2}
+{"abstract_id": "24840756", "label": "results", "text": "There were @ children with known MABC corrected-age percentile as well as known Full-Scale IQ at @ years and cerebral palsy status , of whom @ had been randomly assigned to caffeine and @ to placebo therapy .", "sentence_id": 3}
+{"abstract_id": "24840756", "label": "results", "text": "The rate of DCD was lower in those treated with caffeine ( @ % ) than in the placebo group ( @ % ) ( OR adjusted for center and baseline covariates , @ , @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24840756", "label": "conclusions", "text": "Neonatal caffeine therapy for apnea of prematurity reduces the rate of DCD at @ years of age .", "sentence_id": 5}
+{"abstract_id": "24840756", "label": "conclusions", "text": "As more children have DCD than have cerebral palsy , this is an important additional benefit from neonatal caffeine treatment .", "sentence_id": 6}
+{"abstract_id": "25845088", "label": "objective", "text": "To determine whether exercise training might exert anti-inflammatory effect by reducing HMGB@ levels in women with breast cancer ( BC ) .", "sentence_id": 0}
+{"abstract_id": "25845088", "label": "methods", "text": "We analyzed monocentric data from the DIANA ( DIET AND ANDROGENS ) -@ PROJECT .", "sentence_id": 1}
+{"abstract_id": "25845088", "label": "methods", "text": "Study population consisted of @ patients randomized into two groups : @ patients ( @ + / - @ yrs , training group ) were assigned to a structured exercise training intervention ( @ times/week for the first @ months , and once / week for the following @ months ) ; whereas @ patients ( @ + / - @ yrs , control group ) followed only the general indications to adhere to the life-style intervention suggestions of the DIANA protocol .", "sentence_id": 2}
+{"abstract_id": "25845088", "label": "methods", "text": "At study entry and after @ months , all patients underwent cardiopulmonary exercise testing , biochemical as - sessment -LSB- HMGB@ , high-sensitivity C-reactive protein ( hs-CRP ) , interleukin-@ ( IL-@ ) -RSB- ; and lipid and glycemic profile .", "sentence_id": 3}
+{"abstract_id": "25845088", "label": "results", "text": "There were no significant differences between groups in baseline clinical and inflammatory profile .", "sentence_id": 4}
+{"abstract_id": "25845088", "label": "results", "text": "Among the training group , only @/@ patients had high adherence to the exercise intervention .", "sentence_id": 5}
+{"abstract_id": "25845088", "label": "results", "text": "After stratifying the study population according to the level of adhesion to the exer - cise intervention , @-year HMGB@ levels were lower among patients more adherent to exercise ( p for trend = @ ) .", "sentence_id": 6}
+{"abstract_id": "25845088", "label": "results", "text": "Further adjusting for age , body mass index and baseline values , @-year HMGB@ levels remained significantly and inversely associated to the level of adhesion to the exercise intervention ( B = -@ , SE = @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25845088", "label": "conclusions", "text": "Moderate intensity exercise training in BC survivors is associated with reduced HMGB@ levels that are proportional to the level of adhesion to the exercise intervention , independently from other classical inflammatory molecules , suggesting an exercise-induced anti-inflammatory effect mediated by HMGB@ .", "sentence_id": 8}
+{"abstract_id": "25010236", "label": "background", "text": "According to the literature , @ % of injuries affecting school-age children are sports related .", "sentence_id": 0}
+{"abstract_id": "25010236", "label": "background", "text": "The role of physical education students , as future teachers , seems to be of high importance in terms of protecting children 's safety during sports classes .", "sentence_id": 1}
+{"abstract_id": "25010236", "label": "objective", "text": "The aim is to evaluate the level of basic life support ( BLS ) knowledge and skills in physical education students instructed with the use of different methods .", "sentence_id": 2}
+{"abstract_id": "25010236", "label": "methods", "text": "Second-year physical education students ( n = @ , M age = @ years ) were randomly assigned to three groups : experimental @ ( E@ ) , experimental @ ( E@ ) , and control ( C ) .", "sentence_id": 3}
+{"abstract_id": "25010236", "label": "methods", "text": "Group E@ students participated in a @-hour BLS course based on computer-assisted presentations .", "sentence_id": 4}
+{"abstract_id": "25010236", "label": "methods", "text": "Group E@ trainees practiced BLS algorithm in pairs during a @-hour course .", "sentence_id": 5}
+{"abstract_id": "25010236", "label": "methods", "text": "No manikins were used in both intervention groups .", "sentence_id": 6}
+{"abstract_id": "25010236", "label": "methods", "text": "Students of Group C were asked to learn BLS algorithm on their own .", "sentence_id": 7}
+{"abstract_id": "25010236", "label": "methods", "text": "All groups fulfilled a @-question multiple-choice test on BLS at the beginning and the end of the experiment .", "sentence_id": 8}
+{"abstract_id": "25010236", "label": "methods", "text": "After completing the course participants performed BLS on a manikin .", "sentence_id": 9}
+{"abstract_id": "25010236", "label": "results", "text": "The results of knowledge test were not significant before an experiment but differed essentially among the groups afterward ( analysis of variance contrast analysis , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25010236", "label": "results", "text": "Regardless of teaching method used , no significant differences were found among the students in preparatory BLS actions and cardiopulmonary resuscitation ( CPR ) performance on a manikin .", "sentence_id": 11}
+{"abstract_id": "25010236", "label": "results", "text": "The level of CPR performance was very low in all groups .", "sentence_id": 12}
+{"abstract_id": "25010236", "label": "conclusions", "text": "Students of both intervention groups improved their BLS knowledge after the training .", "sentence_id": 13}
+{"abstract_id": "25010236", "label": "conclusions", "text": "Teaching methods used in the current study seemed to be ineffective in terms of practical CPR skills .", "sentence_id": 14}
+{"abstract_id": "25010236", "label": "conclusions", "text": "Access to greater number of modern manikins should improve the BLS training in physical education students .", "sentence_id": 15}
+{"abstract_id": "25010236", "label": "conclusions", "text": "Moreover , permanent consultation on instructional methods with emergency medicine experts is recommended for university teachers .", "sentence_id": 16}
+{"abstract_id": "24621834", "label": "background", "text": "This study evaluated the efficacy and safety of levosimendan , a positive inotropic drug with vasodilator effects , given intravenously to patients with acutely decompensated heart failure ( ADHF ) .", "sentence_id": 0}
+{"abstract_id": "24621834", "label": "methods", "text": "We performed @ sequential trials , the first to develop a new measure of efficacy in @ patients , and the second to use this measure to evaluate levosimendan in an additional @ patients .", "sentence_id": 1}
+{"abstract_id": "24621834", "label": "methods", "text": "Patients admitted with ADHF received placebo or intravenous levosimendan for @ h in addition to standard treatment .", "sentence_id": 2}
+{"abstract_id": "24621834", "label": "methods", "text": "The primary endpoint was a composite that evaluated changes in clinical status during the first @ days after randomization .", "sentence_id": 3}
+{"abstract_id": "24621834", "label": "results", "text": "In the @-patient trial , more levosimendan than placebo patients ( @ vs. @ ) were improved at all @ pre-specified time points ( @ h , @ h , and @ days ) , whereas fewer levosimendan patients ( @ vs. @ ) experienced clinical worsening ( p = @ for the difference between the groups ) .", "sentence_id": 4}
+{"abstract_id": "24621834", "label": "results", "text": "These differences were apparent , despite more frequent intensification of adjunctive therapy in the placebo group ( @ vs. @ patients ) .", "sentence_id": 5}
+{"abstract_id": "24621834", "label": "results", "text": "Improvements in patient self-assessment and declines in B-type natriuretic peptide levels with levosimendan persisted for @ days and were associated with reduced length of stay ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24621834", "label": "results", "text": "Similar findings were present in the @-patient pilot trial .", "sentence_id": 7}
+{"abstract_id": "24621834", "label": "results", "text": "Levosimendan was associated with more frequent hypotension and cardiac arrhythmias during the infusion period and a numerically higher risk of death across the @ trials ( @ of @ on a regimen of levosimendan vs. @ of @ on a regimen of placebo at @ days , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24621834", "label": "conclusions", "text": "In patients with ADHF , intravenous levosimendan provided rapid and durable symptomatic relief .", "sentence_id": 9}
+{"abstract_id": "24621834", "label": "conclusions", "text": "As dosed in this trial , levosimendan was associated with an increased risk of adverse cardiovascular events .", "sentence_id": 10}
+{"abstract_id": "24621834", "label": "conclusions", "text": "( Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure ; NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "25171502", "label": "objective", "text": "To compare the treatment outcome of tamsulosin @ mg ( TAM ) with or without solifenacin @ mg ( SOL ) for the most bothersome symptom in male lower urinary tract symptoms ( LUTS ) with overactive bladder ( OAB ) .", "sentence_id": 0}
+{"abstract_id": "25171502", "label": "methods", "text": "Male LUTS/OAB ( @ years ) patients who had a total International Prostate Symptom Score ( I-PSS ) of @ , I-PSS urgency-related question of @ , and quality of life ( QoL ) of @ points were enrolled .", "sentence_id": 1}
+{"abstract_id": "25171502", "label": "methods", "text": "Patients who complained of storage symptoms as the most bothersome were included in the ` storage ' group .", "sentence_id": 2}
+{"abstract_id": "25171502", "label": "methods", "text": "Patients who complained of voiding symptoms as the most bothersome were included in the ` voiding ' group .", "sentence_id": 3}
+{"abstract_id": "25171502", "label": "methods", "text": "The change in the I-PSS was compared between the two groups @ weeks after commencing treatment .", "sentence_id": 4}
+{"abstract_id": "25171502", "label": "results", "text": "In the storage group , @ were able to finish this study ( TAM : @ , TAM + SOL : @ ) .", "sentence_id": 5}
+{"abstract_id": "25171502", "label": "results", "text": "The improvement of I-PSS and QoL with TAM + SOL was significantly greater than with TAM alone ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25171502", "label": "results", "text": "In the voiding group , @ were able to finish the study ( TAM : @ , TAM + SOL : @ ) .", "sentence_id": 7}
+{"abstract_id": "25171502", "label": "results", "text": "The improvement of I-PSS and QoL with TAM alone was significantly greater than with TAM + SOL ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25171502", "label": "conclusions", "text": "The most bothersome symptom in male LUTS/OAB should be considered when choosing the appropriate medical treatment .", "sentence_id": 9}
+{"abstract_id": "25384338", "label": "background", "text": "Multiple phase-@ trials in men with biochemically-recurrent prostate cancer ( BRPC ) have assessed the impact of nonhormonal agents on PSA kinetics .", "sentence_id": 0}
+{"abstract_id": "25384338", "label": "background", "text": "We have previously demonstrated that changes in PSA kinetics correlate with metastasis-free survival ; however , it is unknown whether these changes also correlate with overall survival ( OS ) .", "sentence_id": 1}
+{"abstract_id": "25384338", "label": "methods", "text": "We performed a combined retrospective analysis of @ men with BRPC treated on phase-@ trials using one of four investigational drugs : lenalidomide ( n = @ ) , marimastat ( n = @ ) , ATN-@ ( n = @ ) and imatinib ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25384338", "label": "methods", "text": "We examined factors influencing OS , including within-subject changes in PSA kinetics ( PSA slope , PSA doubling time and PSA velocity ) , before and @ months after treatment initiation .", "sentence_id": 3}
+{"abstract_id": "25384338", "label": "results", "text": "After a median follow-up of @ months , @ of @ men had died .", "sentence_id": 4}
+{"abstract_id": "25384338", "label": "results", "text": "In univariate Cox regression analysis , two factors were associated with OS : baseline PSA velocity and change in PSA velocity on therapy .", "sentence_id": 5}
+{"abstract_id": "25384338", "label": "results", "text": "In a landmark multivariable model , stratified by study ( which controlled for age , Gleason score , type of local therapy and use of androgen-deprivation therapy prior to metastases ) , baseline PSA velocity and increase in PSA velocity on therapy remained independent predictors of OS .", "sentence_id": 6}
+{"abstract_id": "25384338", "label": "results", "text": "Median OS for men with an increase in PSA velocity on treatment was @ months and was not reached for men with a decrease in PSA velocity ( hazard ratio = @ , @ % confidence interval @-@ @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25384338", "label": "conclusions", "text": "This hypothesis-generating study suggests that within-subject changes in PSA velocity after initiation of nonhormonal therapy may correlate with OS in men with BRPC .", "sentence_id": 8}
+{"abstract_id": "25384338", "label": "conclusions", "text": "If validated in prospective trials , change in PSA velocity may represent a reasonable intermediate end point for screening new agents in these patients .", "sentence_id": 9}
+{"abstract_id": "24882460", "label": "objective", "text": "The aims of the present study were to evaluate the efficacy of and compliance with a new device for autoinflation in the treatment of persistent otitis media with effusion ( OME ) in young children .", "sentence_id": 0}
+{"abstract_id": "24882460", "label": "methods", "text": "Forty-five children with persistent OME with a bilateral type B or C@ tympanogram for at least three months and history of subjective hearing loss , waiting for grommet surgery , were randomised to a treatment and a control group .", "sentence_id": 1}
+{"abstract_id": "24882460", "label": "methods", "text": "Twenty-three children aged between three and eight years started as the treatment group with the new device for autoinflation .", "sentence_id": 2}
+{"abstract_id": "24882460", "label": "methods", "text": "Another @ children , aged between two and eight years were included as controls .", "sentence_id": 3}
+{"abstract_id": "24882460", "label": "methods", "text": "After a period of four weeks , a cross-over was performed .", "sentence_id": 4}
+{"abstract_id": "24882460", "label": "methods", "text": "Both groups underwent otomicroscopy , tympanometry and audiometry at inclusion and after one and two months for the evaluation of treatment efficiency .", "sentence_id": 5}
+{"abstract_id": "24882460", "label": "methods", "text": "The primary outcome measurements were improvement in middle-ear pressure and hearing thresholds at eight weeks .", "sentence_id": 6}
+{"abstract_id": "24882460", "label": "methods", "text": "Both groups were then followed up for another @ months .", "sentence_id": 7}
+{"abstract_id": "24882460", "label": "results", "text": "In the treatment group , the mean middle-ear pressure for both ears and the mean hearing thresholds for the best ear improved by @ daPa ( p < @ ) and @ dB ( p < @ ) , respectively after four weeks , while in the control group , non-significant alterations were observed .", "sentence_id": 8}
+{"abstract_id": "24882460", "label": "results", "text": "After the cross-over of the control group to treatment , equivalent improvements in the mean middle-ear pressure and the mean hearing thresholds of @ daPa ( p < @ ) and @ dB ( p < @ ) , respectively were achieved also in this group .", "sentence_id": 9}
+{"abstract_id": "24882460", "label": "results", "text": "After treatment in both groups at eight weeks , four of @ children were submitted to grommet surgery .", "sentence_id": 10}
+{"abstract_id": "24882460", "label": "results", "text": "During the long-term follow-up another five children were submitted to surgery due to recurrence of disease .", "sentence_id": 11}
+{"abstract_id": "24882460", "label": "results", "text": "All the children managed to perform the manoeuvre and no side-effects were detected .", "sentence_id": 12}
+{"abstract_id": "24882460", "label": "conclusions", "text": "The device demonstrated efficiency in improving both middle-ear pressure and hearing thresholds in most children after four weeks of treatment .", "sentence_id": 13}
+{"abstract_id": "24882460", "label": "conclusions", "text": "It might therefore be possible to consider this method of autoinflation in children with persistent OME during the watchful waiting period .", "sentence_id": 14}
+{"abstract_id": "24291151", "label": "background", "text": "The negative consequences of unhealthy weight gain and the high likelihood of pediatric obesity tracking into adulthood highlight the importance of targeting youth who are ` at risk ' of obesity .", "sentence_id": 0}
+{"abstract_id": "24291151", "label": "background", "text": "The aim of this paper is to report the rationale and study protocol for the ` Active Teen Leaders Avoiding Screen-time ' ( ATLAS ) obesity prevention intervention for adolescent boys living in low-income communities .", "sentence_id": 1}
+{"abstract_id": "24291151", "label": "methods", "text": "The ATLAS intervention will be evaluated using a cluster randomized controlled trial in @ secondary schools in the state of New South Wales ( NSW ) , Australia ( @ to @ ) .", "sentence_id": 2}
+{"abstract_id": "24291151", "label": "methods", "text": "ATLAS is an @-month multi-component , school-based program informed by self-determination theory and social cognitive theory .", "sentence_id": 3}
+{"abstract_id": "24291151", "label": "methods", "text": "The intervention consists of teacher professional development , enhanced school-sport sessions , researcher-led seminars , lunch-time physical activity mentoring sessions , pedometers for self-monitoring , provision of equipment to schools , parental newsletters , and a smartphone application and website .", "sentence_id": 4}
+{"abstract_id": "24291151", "label": "methods", "text": "Assessments were conducted at baseline and will be completed again at @ - and @-months from baseline .", "sentence_id": 5}
+{"abstract_id": "24291151", "label": "methods", "text": "Primary outcomes are body mass index ( BMI ) and waist circumference .", "sentence_id": 6}
+{"abstract_id": "24291151", "label": "methods", "text": "Secondary outcomes include BMI z-scores , body fat ( bioelectrical impedance analysis ) , physical activity ( accelerometers ) , muscular fitness ( grip strength and push-ups ) , screen-time , sugar-sweetened beverage consumption , resistance training skill competency , daytime sleepiness , subjective well-being , physical self-perception , pathological video gaming , and aggression .", "sentence_id": 7}
+{"abstract_id": "24291151", "label": "methods", "text": "Hypothesized mediators of behavior change will also be explored .", "sentence_id": 8}
+{"abstract_id": "24291151", "label": "conclusions", "text": "ATLAS is an innovative school-based intervention designed to improve the health behaviors and related outcomes of adolescent males in low-income communities .", "sentence_id": 9}
+{"abstract_id": "24682081", "label": "objective", "text": "Our recent work indicates that endogenous opioid activity influences analgesic responses to opioid medications .", "sentence_id": 0}
+{"abstract_id": "24682081", "label": "objective", "text": "This secondary analysis evaluated whether endogenous opioid activity is associated with degree of opioid analgesic adverse effects , and whether chronic pain status and sex affect these adverse effects .", "sentence_id": 1}
+{"abstract_id": "24682081", "label": "methods", "text": "Using a double-blind , randomized , placebo-controlled , crossover design , @ subjects with chronic low back pain and @ healthy controls participated in @ separate sessions , undergoing @ laboratory-evoked pain tasks ( ischemic and thermal ) after receiving placebo , naloxone , or morphine .", "sentence_id": 2}
+{"abstract_id": "24682081", "label": "methods", "text": "Endogenous opioid system function was indexed by the difference in pain responses between the placebo and naloxone conditions .", "sentence_id": 3}
+{"abstract_id": "24682081", "label": "methods", "text": "These measures were examined for associations with morphine-related adverse effects .", "sentence_id": 4}
+{"abstract_id": "24682081", "label": "results", "text": "Chronic pain subjects reported significantly greater itching and unpleasant bodily sensations with morphine than controls ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24682081", "label": "results", "text": "Across groups , only @ of @ possible associations between adverse effects and blockade effects were significant .", "sentence_id": 6}
+{"abstract_id": "24682081", "label": "results", "text": "For the ischemic task , higher endogenous opioid function was associated with greater itching ( visual analog scale -LSB- VAS -RSB- ; P < @ ) , numbness ( tolerance ; P < @ ) , dry mouth ( tolerance ; P < @ ) , and unpleasant bodily sensations ( VAS ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24682081", "label": "results", "text": "For the thermal task , higher endogenous opioid function was associated with greater numbness ( VAS ; P < @ ) and feeling carefree ( VAS ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24682081", "label": "results", "text": "There were no significant main or interaction effects of chronic pain status or sex on these findings .", "sentence_id": 9}
+{"abstract_id": "24682081", "label": "conclusions", "text": "No consistent relationships were observed between endogenous opioid function and morphine-related adverse effects .", "sentence_id": 10}
+{"abstract_id": "24682081", "label": "conclusions", "text": "This is in stark contrast to our previous observation of strong relationships between elevated endogenous opioid function and smaller morphine analgesic effects .", "sentence_id": 11}
+{"abstract_id": "25098612", "label": "objective", "text": "A new core biopsy needle for endoscopic ultrasound ( EUS ) - guided sampling has recently been developed .", "sentence_id": 0}
+{"abstract_id": "25098612", "label": "objective", "text": "The aim of this prospective multicenter study was to compare this needle with a standard needle in patients with solid pancreatic masses .", "sentence_id": 1}
+{"abstract_id": "25098612", "label": "methods", "text": "Consecutive patients with solid pancreatic masses referred to @ centers for EUS-guided sampling were included .", "sentence_id": 2}
+{"abstract_id": "25098612", "label": "methods", "text": "Each patient had two passes with a standard @G needle and a single pass with a @G core needle performed in a randomized order .", "sentence_id": 3}
+{"abstract_id": "25098612", "label": "methods", "text": "Samples from both needles were separately processed for liquid-based cytology and cell-block preparation and were assessed independently by two blinded expert pathologists .", "sentence_id": 4}
+{"abstract_id": "25098612", "label": "methods", "text": "The primary endpoint was the accuracy of the detection of malignancy .", "sentence_id": 5}
+{"abstract_id": "25098612", "label": "methods", "text": "The reference standard was based on further cytohistological analysis obtained under ultrasound or computed tomography scanning , endoscopic or surgical guidance , and/or by clinical follow-up with repeated imaging examinations for at least @ months .", "sentence_id": 6}
+{"abstract_id": "25098612", "label": "methods", "text": "The secondary endpoints were the rate of technical failure and the quality of the cytohistological samples obtained .", "sentence_id": 7}
+{"abstract_id": "25098612", "label": "results", "text": "Of the @ patients included ( @ men ; mean age @ ) , @ % had final malignant diagnoses ( adenocarcinoma n = @ , @ % ) .", "sentence_id": 8}
+{"abstract_id": "25098612", "label": "results", "text": "There was no difference between the needles in diagnostic accuracy ( standard needle @ % vs. core needle @ % ; P = @ ) or technical failure .", "sentence_id": 9}
+{"abstract_id": "25098612", "label": "results", "text": "Both pathologists found the overall sample quality significantly better for the standard needle ( expert @ , P = @ ; expert @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25098612", "label": "conclusions", "text": "The diagnostic accuracy of EUS sampling for solid pancreatic masses using standard and core needles seems comparable but with a better overall histological sample quality for the former .", "sentence_id": 11}
+{"abstract_id": "25098612", "label": "conclusions", "text": "ClinicalTrial.gov identifier : NCT@ .", "sentence_id": 12}
+{"abstract_id": "24717698", "label": "objective", "text": "The purpose of this study was to evaluate the safety and efficacy of three different intravenous ( IV ) doses of palonosetron compared with placebo for the prevention of postoperative nausea and vomiting ( PONV ) in children undergoing dental rehabilitation under general anesthesia ( DRGA ) in the first @ hours after discharge .", "sentence_id": 0}
+{"abstract_id": "24717698", "label": "methods", "text": "A total of @ children who were classified with an American Society of Anesthesiologists physical status of I and II , between three and @ years old ( mean = @ years old ) , and undergoing DRGA were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "24717698", "label": "methods", "text": "The children were randomized to receive one of the three doses of palonosetron ( @ mg , @ mg , or @ mg ) or placebo immediately before induction of anesthesia .", "sentence_id": 2}
+{"abstract_id": "24717698", "label": "results", "text": "Compared with placebo , the incidence of PONV was significantly lower in the palonosetron groups ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24717698", "label": "results", "text": "However , there were no statistically significant differences among the palonosetron groups regarding the number of children with PONV during all time periods after anesthesia ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24717698", "label": "conclusions", "text": "A single @ mg intravenous dose of palonosetron is recommended for further evaluation , as it appears to be an effective dose for prevention of postoperative nausea and vomiting in children undergoing dental rehabilitation under general anesthesia .", "sentence_id": 5}
+{"abstract_id": "25256813", "label": "objective", "text": "To assess bacillus Calmette-Gurin maintenance treatment schedule for non-muscle invasive bladder cancer at @ years , using one-third of the full dose and fewer instillations every @ months or @ months .", "sentence_id": 0}
+{"abstract_id": "25256813", "label": "methods", "text": "This was a prospective , randomized , multicenter study .", "sentence_id": 1}
+{"abstract_id": "25256813", "label": "methods", "text": "All patients had an intermediate - or high-risk non-muscle invasive bladder cancer .", "sentence_id": 2}
+{"abstract_id": "25256813", "label": "methods", "text": "They received three weekly instillations of one-third dose bacillus Calmette-Gurin every @ months ( group I ) and two weekly instillations every @ months ( group II ) during @ years .", "sentence_id": 3}
+{"abstract_id": "25256813", "label": "methods", "text": "In the two schedules we assessed efficacy , tolerance , leukocyturia and prostate-specific antigen .", "sentence_id": 4}
+{"abstract_id": "25256813", "label": "results", "text": "No significant difference was observed between the two groups for recurrence at @ , @ or @ months .", "sentence_id": 5}
+{"abstract_id": "25256813", "label": "results", "text": "At @ years , tumor recurrence was observed in @ % and muscle invasion in @ % of cases .", "sentence_id": 6}
+{"abstract_id": "25256813", "label": "results", "text": "Bacillus Calmette-Gurin tolerance was comparable - the adverse events score was @ in group I and @ in group II ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25256813", "label": "results", "text": "No statistical correlation was observed between the adverse events score over @ years , either for leukocyturia ( P = @ ) or prostate-specific antigen level ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25256813", "label": "results", "text": "Leukocyturia level was not significantly associated with tumor recurrence or progression .", "sentence_id": 9}
+{"abstract_id": "25256813", "label": "conclusions", "text": "One-third dose maintenance bacillus Calmette-Gurin is effective with no impact on tumor recurrence or muscle invasion .", "sentence_id": 10}
+{"abstract_id": "25256813", "label": "conclusions", "text": "Furthermore , there seems to be no difference in tumor response or side-effects between patients receiving two or three maintenance instillations every @ months or @ months .", "sentence_id": 11}
+{"abstract_id": "25256813", "label": "conclusions", "text": "In clinical practice , the use of leukocyturia or total prostate-specific antigen levels do not appear to be useful in predicting bacillus Calmette-Gurin toxicity .", "sentence_id": 12}
+{"abstract_id": "25217488", "label": "objective", "text": "To evaluate the usefulness of velocity ratio ( VR ) in patients with low gradient severe aortic stenosis ( LGSAS ) and preserved EF .", "sentence_id": 0}
+{"abstract_id": "25217488", "label": "background", "text": "LGSAS despite preserved EF represents a clinically challenging entity .", "sentence_id": 1}
+{"abstract_id": "25217488", "label": "background", "text": "Reliance on mean pressure gradient ( MPG ) may underestimate stenosis severity as has been reported in the context of paradoxical low flow , LGSAS .", "sentence_id": 2}
+{"abstract_id": "25217488", "label": "background", "text": "On the other hand , grading of stenosis severity by aortic valve area ( AVA ) may overrate stenosis severity due to erroneous underestimation of LV outflow tract ( LVOT ) diameter , small body size or inconsistencies in cut-off values for severe stenosis .", "sentence_id": 3}
+{"abstract_id": "25217488", "label": "background", "text": "We hypothesised that VR may have conceptual advantages over MPG and AVA , predict clinical outcomes and thereby be useful in the management of patients with LGSAS .", "sentence_id": 4}
+{"abstract_id": "25217488", "label": "methods", "text": "Patients from the prospective Simvastatin and Ezetimibe in Aortic Stenosis ( SEAS ) study with an AVA < @ cm ( @ ) , MPG@mmHg and EF@ % and asymptomatic at baseline were stratified according to VR with a cut-off value of @ .", "sentence_id": 5}
+{"abstract_id": "25217488", "label": "methods", "text": "Outcomes were evaluated according to aortic valve-related events and cardiovascular death .", "sentence_id": 6}
+{"abstract_id": "25217488", "label": "results", "text": "Of @ patients with LGSAS , @ ( @ % ) had VR < @ suggesting severe and @ ( @ % ) had VR@ @ suggesting non-severe stenosis .", "sentence_id": 7}
+{"abstract_id": "25217488", "label": "results", "text": "Aortic valve-related events ( mean follow-up @months ) were more frequent in patients with VR < @ ( @ % vs @ % ; p < @ ) as was cardiovascular death within the first @months ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25217488", "label": "results", "text": "In multivariable Cox regression analysis , MPG was the strongest independent predictor of aortic valve events ( p < @ ) followed by VR ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25217488", "label": "results", "text": "Adjusting AVA by VR increased predictive accuracy for aortic valve events ( area under the receiver operating curve @ ( @ % CI @ to @ ) vs @ ( @ % CI @ to @ ) for AVA , p = @ ) with net reclassification improvement calculated at @ ( @ % CI @ to @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25217488", "label": "results", "text": "VR did not improve the prediction of clinical events by MPG .", "sentence_id": 11}
+{"abstract_id": "25217488", "label": "conclusions", "text": "In the difficult setting of LGSAS , VR shows a strong association with valve-related events and-although not outperforming MPG-may be particularly useful in guiding clinical management .", "sentence_id": 12}
+{"abstract_id": "24944332", "label": "objective", "text": "The objective was to assess the long-term safety profile of dual-release hydrocortisone ( DR-HC ) in patients with adrenal insufficiency ( AI ) .", "sentence_id": 0}
+{"abstract_id": "24944332", "label": "methods", "text": "Randomised , open-label , crossover trial of DR-HC or thrice-daily hydrocortisone for @ months each ( stage @ ) followed by two consecutive , prospective , open-label studies of DR-HC for @ months ( stage @ ) and @ months ( stage @ ) at five university clinics in Sweden .", "sentence_id": 1}
+{"abstract_id": "24944332", "label": "methods", "text": "Sixty-four adults with primary AI started stage @ , and an additional @ entered stage @ .", "sentence_id": 2}
+{"abstract_id": "24944332", "label": "methods", "text": "Patients received DR-HC @-@mg once daily and hydrocortisone @-@mg divided into three daily doses ( stage @ only ) .", "sentence_id": 3}
+{"abstract_id": "24944332", "label": "methods", "text": "Main outcome measures were adverse events ( AEs ) and intercurrent illness ( self-reported hydrocortisone use during illness ) .", "sentence_id": 4}
+{"abstract_id": "24944332", "label": "results", "text": "In stage @ , patients had a median @ ( range , @-@ ) intercurrent illness events with DR-HC and @ ( @-@ ) with thrice-daily hydrocortisone .", "sentence_id": 5}
+{"abstract_id": "24944332", "label": "results", "text": "AEs during stage @ were not related to the cortisol exposure-time profile .", "sentence_id": 6}
+{"abstract_id": "24944332", "label": "results", "text": "The percentage of patients with one or more AEs during stage @ ( @ % with DR-HC ; @ % with thrice-daily hydrocortisone ) decreased during stage @ , when all patients received DR-HC ( @ % in the first @ months ; @ % in the second @ months ) .", "sentence_id": 7}
+{"abstract_id": "24944332", "label": "results", "text": "In stages @-@ combined , @ patients experienced @ serious AEs , equating to @ serious AEs/@ patient-years of DR-HC exposure .", "sentence_id": 8}
+{"abstract_id": "24944332", "label": "conclusions", "text": "This long-term prospective trial is the first to document the safety of DR-HC in patients with primary AI and demonstrates that such treatment is well tolerated during @ consecutive months of therapy .", "sentence_id": 9}
+{"abstract_id": "25029619", "label": "background", "text": "Low-fat and low-carbohydrate weight-loss diets can have a beneficial effect on longitudinal measures of blood pressure and blood lipids .", "sentence_id": 0}
+{"abstract_id": "25029619", "label": "background", "text": "We aimed to assess longitudinal changes in blood pressure and blood lipids in a population of premenopausal women .", "sentence_id": 1}
+{"abstract_id": "25029619", "label": "background", "text": "We hypothesized that results may differ by level of adherence to the respective diet protocol and baseline presence of hypertension or hyperlipidemia .", "sentence_id": 2}
+{"abstract_id": "25029619", "label": "methods", "text": "Overweight or obese premenopausal women were randomized to a low-fat ( n = @ ) or low-carbohydrate ( n = @ ) diet .", "sentence_id": 3}
+{"abstract_id": "25029619", "label": "methods", "text": "As part of the @-week Lifestyle Eating and Fitness ( LEAF ) intervention trial , we fit linear mixed models to determine whether a change in outcome differed by treatment arm .", "sentence_id": 4}
+{"abstract_id": "25029619", "label": "results", "text": "Within-group trends in blood pressure and blood lipids did not differ ( p > @ ) .", "sentence_id": 5}
+{"abstract_id": "25029619", "label": "results", "text": "Across study arms , there was a significant decrease in systolic blood pressure ( SBP , @mm Hg , p = @ ) over time , but diastolic blood pressure ( DBP ) did not change significantly over the course of the study .", "sentence_id": 6}
+{"abstract_id": "25029619", "label": "results", "text": "Blood lipids ( total cholesterol -LSB- TC -RSB- , low-density lipoproteins -LSB- LDL -RSB- , and high-density lipoproteins -LSB- HDL -RSB- ) all exhibited nonlinear trends over time ( p < @ ) ; each decreased initially but returned to levels comparable to baseline by study conclusion ( p > @ ) .", "sentence_id": 7}
+{"abstract_id": "25029619", "label": "results", "text": "We observed a decline in SBP among women who were hypertensive at baseline ( p < @ ) , but hypercholesterolemia at baseline did not affect trends in blood lipids ( p > @ ) .", "sentence_id": 8}
+{"abstract_id": "25029619", "label": "conclusions", "text": "Our results support that dietary interventions may be efficacious for lowering blood pressure and blood lipids among overweight or obese premenopausal women .", "sentence_id": 9}
+{"abstract_id": "25029619", "label": "conclusions", "text": "However , a decrease in SBP was the only favorable change that was sustained in this study population .", "sentence_id": 10}
+{"abstract_id": "25029619", "label": "conclusions", "text": "These changes can be maintained over the course of a @-year intervention , yet changes in blood lipids may be less sustainable .", "sentence_id": 11}
+{"abstract_id": "24767098", "label": "background", "text": "Intrafraction tumour motion in helical tomotherapy was investigated by comparing pre - and mid-fraction CT scans in patients with early non-small cell lung carcinoma ( NSCLC ) to assess the efficacy of a @-mm margin around gross tumour volumes ( GTVs ) in stereotactic body radiation therapy ( SBRT ) .", "sentence_id": 0}
+{"abstract_id": "24767098", "label": "methods", "text": "Thirty patients with early-stage NSCLC received SBRT in four or five fractions for a total of @ treatments .", "sentence_id": 1}
+{"abstract_id": "24767098", "label": "methods", "text": "A slow positron emission tomography/CT scan was fused with the simulation CT to determine the GTV .", "sentence_id": 2}
+{"abstract_id": "24767098", "label": "methods", "text": "A planning target volume was created by placing an isotropic margin of @mm around the GTV .", "sentence_id": 3}
+{"abstract_id": "24767098", "label": "methods", "text": "Data were retrospectively analyzed to assess translational tumour positional changes along the x , y and z axes and vector changes in millimeters from the pretreatment megavoltage ( MV ) - CT to the mid-fraction MV-CT .", "sentence_id": 4}
+{"abstract_id": "24767098", "label": "results", "text": "Average movements for all @ treatment days along the x , y and z axes were @ , -@ and @ mm , respectively .", "sentence_id": 5}
+{"abstract_id": "24767098", "label": "results", "text": "Average movements for each patient along the x , y and z axes were @ , -@ and @ mm , respectively .", "sentence_id": 6}
+{"abstract_id": "24767098", "label": "results", "text": "Average vector displacement was @ mm for all treatment days and @ mm for each patient .", "sentence_id": 7}
+{"abstract_id": "24767098", "label": "results", "text": "Of @ treatments , @ ( @ % ) fell within @ mm in all axes .", "sentence_id": 8}
+{"abstract_id": "24767098", "label": "conclusions", "text": "The addition of a @-mm margin to the GTV for patients receiving SBRT for NSCLC using tomotherapy is adequate to account for tumour movement .", "sentence_id": 9}
+{"abstract_id": "24767098", "label": "conclusions", "text": "Mid-fraction CT scans proved to be valuable in assessing intrafraction tumour motion .", "sentence_id": 10}
+{"abstract_id": "25545858", "label": "objective", "text": "Standard varenicline tartrate dosing was formulated to avoid adverse effects ( primarily nausea ) , but some patients may be underdosed .", "sentence_id": 0}
+{"abstract_id": "25545858", "label": "objective", "text": "To our knowledge , no evidence-based guidance exists for physicians considering increasing varenicline dose if there is no response to the standard dosage .", "sentence_id": 1}
+{"abstract_id": "25545858", "label": "objective", "text": "To determine whether increasing varenicline dose in patients showing no response to the standard dosage improves treatment efficacy .", "sentence_id": 2}
+{"abstract_id": "25545858", "label": "methods", "text": "In a double-blind randomized placebo-controlled trial , @ smokers attending a stop smoking clinic commenced varenicline use @ weeks before their target quit date ( TQD ) .", "sentence_id": 3}
+{"abstract_id": "25545858", "label": "methods", "text": "Two hundred participants reporting no strong nausea , no clear reduction in smoking enjoyment , and less than @ % reduction in their baseline smoking on day @ received additional tablets of varenicline or placebo .", "sentence_id": 4}
+{"abstract_id": "25545858", "label": "methods", "text": "All participants began standard varenicline tartrate dosing , gradually increasing to @ mg/d .", "sentence_id": 5}
+{"abstract_id": "25545858", "label": "methods", "text": "Dose increases of twice-daily varenicline ( @ mg ) or placebo took place on days @ , @ , and @ ( up to a maximum of @ mg/d ) .", "sentence_id": 6}
+{"abstract_id": "25545858", "label": "methods", "text": "Participants rated their smoking enjoyment during the prequit period and withdrawal symptoms weekly for the first @ weeks after the TQD .", "sentence_id": 7}
+{"abstract_id": "25545858", "label": "methods", "text": "Continuous validated abstinence rates were assessed at @ , @ , and @ weeks after the TQD .", "sentence_id": 8}
+{"abstract_id": "25545858", "label": "results", "text": "The dose increase reduced smoking enjoyment during the prequit period , with mean ( SD ) ratings of @ ( @ ) for varenicline vs @ ( @ ) for placebo ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25545858", "label": "results", "text": "It had no effect on the mean ( SD ) frequency of urges to smoke at @ week after the TQD , their strength , or the severity of withdrawal symptoms : these ratings for varenicline vs placebo were @ ( @ ) vs @ ( @ ) ( P = @ ) , @ ( @ ) vs @ ( @ ) ( P = @ ) , and @ ( @ ) vs @ ( @ ) ( P = @ ) , respectively .", "sentence_id": 10}
+{"abstract_id": "25545858", "label": "results", "text": "The dose increase also had no effect on smoking cessation rates for varenicline vs placebo at @ week ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , P = @ ) , @ weeks ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , P = @ ) , and @ weeks ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , P = @ ) after the TQD .", "sentence_id": 11}
+{"abstract_id": "25545858", "label": "results", "text": "There was significantly more nausea ( P < @ ) and vomiting ( P < @ ) reported in the varenicline arm than in the placebo arm .", "sentence_id": 12}
+{"abstract_id": "25545858", "label": "conclusions", "text": "Increasing varenicline dose in smokers with low response to the drug had no significant effect on tobacco withdrawal symptoms or smoking cessation .", "sentence_id": 13}
+{"abstract_id": "25545858", "label": "conclusions", "text": "Physicians often consider increasing the medication dose if there is no response to the standard dosage .", "sentence_id": 14}
+{"abstract_id": "25545858", "label": "conclusions", "text": "This approach may not work with varenicline .", "sentence_id": 15}
+{"abstract_id": "24874316", "label": "objective", "text": "To assess the efficacy of the cytoprotective neuropeptide cortexin in the complex treatment in acute and early rehabilitation stages of ischemic stroke ( II ) .", "sentence_id": 0}
+{"abstract_id": "24874316", "label": "methods", "text": "A multicenter prospective double-blind placebo-controlled trial has been carried out .", "sentence_id": 1}
+{"abstract_id": "24874316", "label": "methods", "text": "Two hundreds and seventy-two patients with II have been enrolled in the trial .", "sentence_id": 2}
+{"abstract_id": "24874316", "label": "methods", "text": "Cortexin was administered in low doses ( @ mg three times a day intramuscular , using the following schemes : group @ : @ courses of cortexin ; group @ : @ course of cortexin with the following course of placebo ; group @ : two courses of placebo .", "sentence_id": 3}
+{"abstract_id": "24874316", "label": "methods", "text": "The duration of treatment was @ days .", "sentence_id": 4}
+{"abstract_id": "24874316", "label": "methods", "text": "Patients were examined during @ visits using clinical tests and instrumental methods .", "sentence_id": 5}
+{"abstract_id": "24874316", "label": "results", "text": "High efficacy and safety of cortexin in the complex treatment of patients with II has been shown .", "sentence_id": 6}
+{"abstract_id": "24874316", "label": "results", "text": "The best therapeutic effect was seen in group @ ( two @-day courses of cortexin ) .", "sentence_id": 7}
+{"abstract_id": "24874316", "label": "results", "text": "The results were confirmed by the pharmacoeconomic analysis of treatment tactics based on the estimation of `` net monetary benefit '' .", "sentence_id": 8}
+{"abstract_id": "24874316", "label": "conclusions", "text": "Cortexin is recommended for treatment and rehabilitation of patients with II .", "sentence_id": 9}
+{"abstract_id": "25936187", "label": "objective", "text": "To compare postoperative blood loss under different negative pressures of drainage after total hip arthroplasty for the treatment of femoral neck fractures .", "sentence_id": 0}
+{"abstract_id": "25936187", "label": "methods", "text": "From January @st to December @th @ , @ patients with femoral neck fractures treated with total hip arthroplasty were randomly divided into two groups : high negative pressure drainage group and low negative pressure drainage group .", "sentence_id": 1}
+{"abstract_id": "25936187", "label": "methods", "text": "In high negative pressure drainage group , there were @ cases including @ males and @ females , with a mean age of ( @ @ ) years old , and the patients were treated with @ kPa negative pressure of drainage .", "sentence_id": 2}
+{"abstract_id": "25936187", "label": "methods", "text": "In the low negative pressure drainage group , there were @ cases including @ males and @ females , with an average age of ( @ @ ) years old , and the patients were treated with @ kPa negative pressure of drainage .", "sentence_id": 3}
+{"abstract_id": "25936187", "label": "methods", "text": "The amount of total drainage , total blood loss , and hemoglobin change were compared between these two groups .", "sentence_id": 4}
+{"abstract_id": "25936187", "label": "results", "text": "All the patients got primary healing without infections .", "sentence_id": 5}
+{"abstract_id": "25936187", "label": "results", "text": "In high negative pressure drainage group , the change of hemoglobin was ( @ @ ) g/L , total blood loss was ( @,@ @ ) ml and the drainage volume was ( @ @ ) ml ; while in low negative pressure drainage group , the results were ( @ @ ) g/L , ( @ @ ) ml and ( @ @ ) ml separately .", "sentence_id": 6}
+{"abstract_id": "25936187", "label": "results", "text": "All the results in high negative pressure drainage group were higher than those in the other group .", "sentence_id": 7}
+{"abstract_id": "25936187", "label": "results", "text": "Three days after operation , the change of hemoglobin was ( @ @ ) g/L and total blood loss was ( @,@ @ ) ml ; while in low negative pressure drainage group , the changes of hemoglobin was ( @ @ ) g/L and total blood loss was ( @,@ @ ) ml ; there were no statistically significant differences between two groups .", "sentence_id": 8}
+{"abstract_id": "25936187", "label": "conclusions", "text": "When placing drainage devices after total hip arthroplasty for the treatment of femoral neck fractures , the level of negative pressure should be chosen according to preoperative level of hemoglobin and HCT in patients .", "sentence_id": 9}
+{"abstract_id": "25936187", "label": "conclusions", "text": "For old patients with femoral neck fracture , low negative pressure is more suitable .", "sentence_id": 10}
+{"abstract_id": "24280475", "label": "objective", "text": "One objective of this study was to assess the effects of laughter on the psychological , immunological and physiological systems of the body .", "sentence_id": 0}
+{"abstract_id": "24280475", "label": "objective", "text": "Another objective was to introduce the Laughing Qigong Program ( LQP ) , as a method of standardization for simulated laughter interventions .", "sentence_id": 1}
+{"abstract_id": "24280475", "label": "methods", "text": "A randomized , prospective , experimental study of the LQP was conducted in a group of adolescents ( n = @ ) in Taiwan .", "sentence_id": 2}
+{"abstract_id": "24280475", "label": "methods", "text": "During study-hall sessions , experimental subjects ( n = @ ) attended the LQP for eight-weeks .", "sentence_id": 3}
+{"abstract_id": "24280475", "label": "methods", "text": "Simultaneously , control subjects ( n = @ ) read or did their homework .", "sentence_id": 4}
+{"abstract_id": "24280475", "label": "methods", "text": "All subjects were tested before and after the intervention on the following : Rosenberg Self-Esteem scale ( RSE ) , Chinese Humor Scale ( CHS ) and Face Scale ( FS ) as psychological markers ; saliva cortisol ( CS ) as an immunological marker ; blood pressure ( BP ) , heart rate ( HR ) , and heart rate variability ( HRV ) as physiological markers of the body 's response to stress .", "sentence_id": 5}
+{"abstract_id": "24280475", "label": "methods", "text": "Mood states ( FS ) were measured before/after each LQP session .", "sentence_id": 6}
+{"abstract_id": "24280475", "label": "results", "text": "Mood states ( p = @ ) and humor ( p = @ ; p = @ ) improved in the experimental group ; no significant changes were found in the controls ( p = @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24280475", "label": "results", "text": "The immunological marker of stress , cortisol levels , decreased significantly for those who participated in the LQP ( p = @ ) , suggesting lower levels of stress after completion of the program .", "sentence_id": 8}
+{"abstract_id": "24280475", "label": "conclusions", "text": "The LQP is a non-pharmacological and cost-effective means to help adolescents mitigate stresses in their everyday life .", "sentence_id": 9}
+{"abstract_id": "25077420", "label": "background", "text": "Neisseria meningitidis serogroup B ( MnB ) is a major cause of invasive meningococcal disease in infants .", "sentence_id": 0}
+{"abstract_id": "25077420", "label": "background", "text": "A conserved , surface-exposed lipoprotein , LP@ ( a factor H-binding protein -LSB- fHBP -RSB- ) , is a promising MnB vaccine target .", "sentence_id": 1}
+{"abstract_id": "25077420", "label": "background", "text": "A bivalent , recombinant vaccine targeting the fHBP ( rLP@ ) of MnB was developed .", "sentence_id": 2}
+{"abstract_id": "25077420", "label": "methods", "text": "This phase @/@ clinical study was designed to assess the immunogenicity , safety , and tolerability of a @-dose series of the rLP@ vaccine at @ - , @ - , @ - , or @-g dose levels in vaccine-naive infants when given with routine childhood vaccines .", "sentence_id": 3}
+{"abstract_id": "25077420", "label": "methods", "text": "The study was to consist of two phases : a single-blind sentinel phase and an open-label full enrollment phase .", "sentence_id": 4}
+{"abstract_id": "25077420", "label": "methods", "text": "During the sentinel phase , randomization of subjects to the next higher dose was delayed pending a @-day safety review of dose @ of the preceding dose cohort .", "sentence_id": 5}
+{"abstract_id": "25077420", "label": "methods", "text": "The full enrollment phase was to occur after completion of the sentinel phase .", "sentence_id": 6}
+{"abstract_id": "25077420", "label": "results", "text": "Local reactions were generally mild and adverse events infrequent ; however , after only @ infants were randomized into the study , fever rates were @ % and @ % in subjects receiving one @ - or @-g rLP@ dose , respectively .", "sentence_id": 7}
+{"abstract_id": "25077420", "label": "results", "text": "Most fevers were < @ C. Only @ subjects in the @-g group and @ subject in the @-g group experienced fevers > @ C ; no fevers were > @ C. Due to these high fever rates , the study was terminated early .", "sentence_id": 8}
+{"abstract_id": "25077420", "label": "results", "text": "No immunogenicity data were collected .", "sentence_id": 9}
+{"abstract_id": "25077420", "label": "results", "text": "This report discusses the safety and acceptability of rLP@ in infants after one @ - or @-g dose .", "sentence_id": 10}
+{"abstract_id": "25077420", "label": "conclusions", "text": "Due to the high fever rate experienced in the @ - and @-g groups , rLP@ in the current formulation may not be acceptable for infants .", "sentence_id": 11}
+{"abstract_id": "24228533", "label": "objective", "text": "To compare effects of integrated treatment traditional Chinese medicine and Western medicine ( TCM-WM ) and simple western medicine on TCM clincal symptoms in the patient of AIDS with pulmonary inflammation .", "sentence_id": 0}
+{"abstract_id": "24228533", "label": "methods", "text": "A multicenter randomized controlled trials of @ subjects evaluated the effects of clinical symptoms of AIDS with pulmonary inflammation of TWO regimens : the TCM-WM group ( n = @ ) and western medicine treatment group ( n = @ ) , while incidence of TCM symptoms in different time points in two groups were analyzed .", "sentence_id": 1}
+{"abstract_id": "24228533", "label": "results", "text": "Twenty eight days after treatment , the cured and markedly effective rate of TCM symptoms in the TCM-WM group significantly exceeding that in the western medicine treatment group ( cured and markedly effective rate significant efficiency @ % vs @ % ) , while the incidence rate for the TCM symptoms of fever and headache in the TCM-WM group was significantly lower than that in western medicine group .", "sentence_id": 2}
+{"abstract_id": "24228533", "label": "conclusions", "text": "The integrated treatment of traditional Chinese medicine and Western medicine helps to alleviate the TCM clinical symptoms of AIDS with pulmonary inflammation .", "sentence_id": 3}
+{"abstract_id": "25239928", "label": "objective", "text": "We evaluated the effects of cognitive speed of processing training ( SOPT ) on the development of additional Instrumental Activities of Daily Living ( IADL ) difficulties and the reduction of depressive symptoms in the Iowa Healthy and Active Minds Study ( IHAMS ) .", "sentence_id": 0}
+{"abstract_id": "25239928", "label": "methods", "text": "Six hundred eighty-one patients were randomized to @ groups : @ hr of on-site SOPT , @ hr of on-site SOPT plus @ hr of boosters , @ hr of at-home SOPT , or @ hr of on-site attention-control ( crossword puzzles ) .", "sentence_id": 1}
+{"abstract_id": "25239928", "label": "methods", "text": "Developing additional difficulties with IADLs and reductions in depressive symptoms @ year later were evaluated using multiple logistic regression .", "sentence_id": 2}
+{"abstract_id": "25239928", "label": "results", "text": "The on-site SOPT with boosters group had reduced odds of developing additional difficulties with IADLs ( adjusted odds ratio -LSB- AOR -RSB- = @ , p = @ ) compared with attention-controls .", "sentence_id": 3}
+{"abstract_id": "25239928", "label": "results", "text": "The on-site SOPT with boosters group also had increased odds of reduced depressive symptom levels ( AOR = @ , p = @ ) compared with attention-controls .", "sentence_id": 4}
+{"abstract_id": "25239928", "label": "conclusions", "text": "These findings provide evidence that SOPT transfers beyond the cognitive skills trained to meaningful downstream improvements in the lives of middle-aged and older adults .", "sentence_id": 5}
+{"abstract_id": "25159241", "label": "background", "text": "The success of damage-control surgery ( DCS ) for the treatment of trauma has led to its use in other surgical problems such as abdominal sepsis .", "sentence_id": 0}
+{"abstract_id": "25159241", "label": "background", "text": "Previous studies using direct peritoneal resuscitation ( DPR ) for the treatment of trauma have yielded promising results .", "sentence_id": 1}
+{"abstract_id": "25159241", "label": "background", "text": "We present the results of the application of this technique to patients experiencing abdominal sepsis .", "sentence_id": 2}
+{"abstract_id": "25159241", "label": "methods", "text": "We enrolled @ DCS patients during a @ year-period ( January @ to December @ ) into a propensity-matched study to evaluate the utility of using DPR in addition to standard resuscitation .", "sentence_id": 3}
+{"abstract_id": "25159241", "label": "methods", "text": "DPR consisted of peritoneal lavage with @ % DELFLEX , and abdominal closure was standardized across both groups .", "sentence_id": 4}
+{"abstract_id": "25159241", "label": "methods", "text": "Patients were matched using Acute Physiology and Chronic Health Evaluation II ( APACHE II ) variables .", "sentence_id": 5}
+{"abstract_id": "25159241", "label": "methods", "text": "Univariate and multivariate analyses were performed .", "sentence_id": 6}
+{"abstract_id": "25159241", "label": "results", "text": "There were no differences between the control and experimental groups with regard to age , sex , ethnicity , or APACHE II at @ hours .", "sentence_id": 7}
+{"abstract_id": "25159241", "label": "results", "text": "Indications for damage control included pancreatitis , perforated hollow viscous , bowel obstruction , and ischemic enterocolitis .", "sentence_id": 8}
+{"abstract_id": "25159241", "label": "results", "text": "Patients undergoing DPR had both a higher rate of ( @ % vs. @ % , p < @ ) and a shorter time to definitive fascial closure ( @ -LSB- @ -RSB- days vs. @ -LSB- @ -RSB- days , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25159241", "label": "results", "text": "DPR patients had a decreased APACHE II and Sequential Organ Failure Assessment ( SOFA ) score compared with the controls at @ hours .", "sentence_id": 10}
+{"abstract_id": "25159241", "label": "results", "text": "In addition , DPR patients had fewer abdominal complications compared with the controls ( RR , @ ; @ % confidence interval , @-@ @ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25159241", "label": "results", "text": "Ventilator days and intensive care unit length of stay were both significantly reduced in the DPR group .", "sentence_id": 12}
+{"abstract_id": "25159241", "label": "results", "text": "The DPR group showed a lower overall mortality at @ days ( @ % vs. @ % , p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25159241", "label": "conclusions", "text": "DPR reduces time to definitive abdominal closure , increases primary fascial closure , and reduces intra-abdominal complications following DCS .", "sentence_id": 14}
+{"abstract_id": "25159241", "label": "conclusions", "text": "DPR may also attenuate progressive physiologic injury as demonstrated by a reduction in @-hour intensive care unit severity scores .", "sentence_id": 15}
+{"abstract_id": "25159241", "label": "conclusions", "text": "As a result , DPR following DCS may afford better outcomes to patients experiencing shock .", "sentence_id": 16}
+{"abstract_id": "25159241", "label": "methods", "text": "Therapeutic study , level III .", "sentence_id": 17}
+{"abstract_id": "24364223", "label": "background", "text": "The importance of vitamin D on bone health and osteoporosis was studied by many researchers .", "sentence_id": 0}
+{"abstract_id": "24364223", "label": "background", "text": "The main role of the Vitamin D is to absorb calcium and phosphate and increase bone mineralization .", "sentence_id": 1}
+{"abstract_id": "24364223", "label": "background", "text": "Older people are at an increased risk of the inadequate vitamin D production in the skin because of lower sun exposure and reduced ability of the skin to synthesize vitamin D.", "sentence_id": 2}
+{"abstract_id": "24364223", "label": "objective", "text": "The aim of this clinical trial was to evaluate the efficacy and tolerability of short-term ( @ weeks ) low energy UVB irradiation in postmenopausal women with osteoporosis using bone mineral density and bone turnover markers .", "sentence_id": 3}
+{"abstract_id": "24364223", "label": "methods", "text": "A three-month , single-blinded , randomized , placebo-controlled clinical trial was conducted at the University hospital in Daegu , Republic of Korea .", "sentence_id": 4}
+{"abstract_id": "24364223", "label": "methods", "text": "Fifty-two postmenopausal Korean women ( older than @ years ) with osteoporosis were randomly allocated to have either low energy UVB or placebo for @ minutes a day for two weeks of treatment during winter .", "sentence_id": 5}
+{"abstract_id": "24364223", "label": "methods", "text": "Laboratory analysis and physical examination before and @ , @ and @ weeks after treatment were carried out and BMD was measured before and @ and @ weeks after treatment .", "sentence_id": 6}
+{"abstract_id": "24364223", "label": "methods", "text": "The effects of time and treatment interaction between these two groups were evaluated by repeated-measure two-factor analysis , and subgroup analysis was performed to examine UVB effect on the vitamin D insufficient group -LSB- serum @ ( OH ) D@ concentration < @ ng/mL -RSB- .", "sentence_id": 7}
+{"abstract_id": "24364223", "label": "results", "text": "In vitamin D insufficient group , the effect of UVB irradiation on vitamin D and bone ALP as well as additional benefit on bone formation was confirmed .", "sentence_id": 8}
+{"abstract_id": "24364223", "label": "results", "text": "The vitamin D insufficient group showed statistically significant increment in serum @ ( OH ) D@ compared with the normal group ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24364223", "label": "results", "text": "However , there was no significant difference between two groups in the other bone turnover markers , such as serum calcium , PTH-C , serum osteocalcin , serum CTX and BMD .", "sentence_id": 10}
+{"abstract_id": "24364223", "label": "conclusions", "text": "Low-energy-short-term UVB radiation for postmenopausal women may be of use in vitamin D synthesis .", "sentence_id": 11}
+{"abstract_id": "24364223", "label": "conclusions", "text": "There was a modest benefit in change of bone ALP especially in women with the insufficient vitamin D.", "sentence_id": 12}
+{"abstract_id": "24816725", "label": "objective", "text": "This phase II study evaluated the synthetic DNA-based immunomodulator and Toll-like receptor @ agonist MGN@ as maintenance treatment in metastatic colorectal carcinoma ( mCRC ) .", "sentence_id": 0}
+{"abstract_id": "24816725", "label": "methods", "text": "Fifty-nine patients with mCRC and disease control after standard first-line chemotherapy were randomised to MGN@ @mg ( N = @ ) or placebo ( N = @ ) .", "sentence_id": 1}
+{"abstract_id": "24816725", "label": "results", "text": "The hazard ratio ( HR ) for the primary endpoint -LSB- progression-free survival ( PFS ) from the start of maintenance -RSB- was @ ( @ % CI @-@ @ ; P = @ ) and @ ( @ % CI @-@ @ ; P = @ ) by independent and investigator review , respectively .", "sentence_id": 2}
+{"abstract_id": "24816725", "label": "results", "text": "MGN@ significantly improved PFS measured from the start of induction therapy versus placebo on independent ( HR @ ; @ % CI @-@ @ ; P = @ ) and investigator review ( HR @ ; @ % CI @-@ @ ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24816725", "label": "results", "text": "Overall survival ( OS ) data remain immature ( HR @ % ; @ % CI @-@ @ ; P = @ ) with @/@ patients alive after a medium follow-up of > @months .", "sentence_id": 4}
+{"abstract_id": "24816725", "label": "results", "text": "Retrospective subgroup analysis showed a significant effect of MGN@ on PFS versus placebo in patients with greater than median tumour size reduction and normalised carcinoembryonic antigen concentrations following induction therapy , and in patients with elevated activated NKT cells@ @ % .", "sentence_id": 5}
+{"abstract_id": "24816725", "label": "results", "text": "Adverse events were mild to moderate and limited to injection-site reactions or linked to general immune system activation .", "sentence_id": 6}
+{"abstract_id": "24816725", "label": "conclusions", "text": "MGN@ maintenance treatment was well tolerated and appears to induce durable and prolonged PFS and disease control in a subgroup of patients with mCRC following induction therapy .", "sentence_id": 7}
+{"abstract_id": "24816725", "label": "conclusions", "text": "Activated NKT cells may be a predictive biomarker for selecting patients likely to benefit more from MGN@ .", "sentence_id": 8}
+{"abstract_id": "25539805", "label": "background", "text": "Rheumatoid Arthritis ( RA ) is one of the most common autoimmune diseases , affecting approximately @ % of the UK adult population .", "sentence_id": 0}
+{"abstract_id": "25539805", "label": "background", "text": "Patients suffer considerable pain , stiffness and swelling and can sustain various degrees of joint destruction , deformity , and significant functional decline .", "sentence_id": 1}
+{"abstract_id": "25539805", "label": "background", "text": "In addition , the economic burden due to hospitalisation and loss of employment is considerable , with over @ % of patients being work-disabled within @years of diagnosis .", "sentence_id": 2}
+{"abstract_id": "25539805", "label": "background", "text": "Despite several biologic disease modifying anti-rheumatic drugs ( bDMARD ) now available , there is a lack of data to guide biologic sequencing .", "sentence_id": 3}
+{"abstract_id": "25539805", "label": "background", "text": "In the UK , second-line biologic treatment is restricted to a single option , rituximab .", "sentence_id": 4}
+{"abstract_id": "25539805", "label": "background", "text": "The aim of the SWITCH trial is to establish whether an alternative-mechanism-TNF-inhibitor ( TNFi ) or abatacept are as effective as rituximab in patients with RA who have failed an initial TNFi drug .", "sentence_id": 5}
+{"abstract_id": "25539805", "label": "methods", "text": "SWITCH is a pragmatic , phase IV , multi-centre , parallel-group design , open-label , randomised , controlled trial ( RCT ) comparing alternative-mechanism-TNFi and abatacept with rituximab in patients with RA who have failed an initial TNFi drug .", "sentence_id": 6}
+{"abstract_id": "25539805", "label": "methods", "text": "Participants are randomised in a @:@:@ ratio to receive alternative mechanism TNFi , ( monoclonal antibodies : infliximab , adalimumab , certolizumab or golimumab or the receptor fusion protein , etanercept ) , abatacept or rituximab during the interventional phase ( from randomisation up to week @ ) .", "sentence_id": 7}
+{"abstract_id": "25539805", "label": "methods", "text": "Participants are subsequently followed up to a maximum of @weeks , which constitutes the observational phase .", "sentence_id": 8}
+{"abstract_id": "25539805", "label": "methods", "text": "The primary objective is to establish whether an alternative-mechanism-TNFi or abatacept are non-inferior to rituximab in terms of disease response at @weeks post randomisation .", "sentence_id": 9}
+{"abstract_id": "25539805", "label": "methods", "text": "The secondary objectives include the comparison of alternative-mechanism-TNFi and abatacept to rituximab in terms of disease response , quality of life , toxicity , safety and structural and bone density outcomes over a @-month period ( @weeks ) and to evaluate the cost-effectiveness of switching patients to alternative active therapies compared to current practice .", "sentence_id": 10}
+{"abstract_id": "25539805", "label": "conclusions", "text": "SWITCH is a well-designed trial in this therapeutic area that aims to develop a rational treatment algorithm to potentially inform personalised treatment regimens ( as opposed to switching all patients to only one available ( and possibly unsuccessful ) therapy ) , which may lead to long-term improved patient outcomes and gains in population health .", "sentence_id": 11}
+{"abstract_id": "24888266", "label": "background", "text": "There is a need for evidence of the clinical effectiveness of minimally invasive surgery for the treatment of esophageal cancer , but randomized controlled trials in surgery are often difficult to conduct .", "sentence_id": 0}
+{"abstract_id": "24888266", "label": "background", "text": "The ROMIO ( Randomized Open or Minimally Invasive Oesophagectomy ) study will establish the feasibility of a main trial which will examine the clinical and cost-effectiveness of minimally invasive and open surgical procedures for the treatment of esophageal cancer .", "sentence_id": 1}
+{"abstract_id": "24888266", "label": "methods", "text": "A pilot randomized controlled trial ( RCT ) , in two centers ( University Hospitals Bristol NHS Foundation Trust and Plymouth Hospitals NHS Trust ) will examine numbers of incident and eligible patients who consent to participate in the ROMIO study .", "sentence_id": 2}
+{"abstract_id": "24888266", "label": "methods", "text": "Interventions will include esophagectomy by : ( @ ) open gastric mobilization and right thoracotomy , ( @ ) laparoscopic gastric mobilization and right thoracotomy , and ( @ ) totally minimally invasive surgery ( in the Bristol center only ) .", "sentence_id": 3}
+{"abstract_id": "24888266", "label": "methods", "text": "The primary outcomes of the feasibility study will be measures of recruitment , successful development of methods to monitor quality of surgery and fidelity to a surgical protocol , and development of a core outcome set to evaluate esophageal cancer surgery .", "sentence_id": 4}
+{"abstract_id": "24888266", "label": "methods", "text": "The study will test patient-reported outcomes measures to assess recovery , methods to blind participants , assessments of surgical morbidity , and methods to capture cost and resource use .", "sentence_id": 5}
+{"abstract_id": "24888266", "label": "methods", "text": "ROMIO will integrate methods to monitor and improve recruitment using audio recordings of consultations between recruiting surgeons , nurses , and patients to provide feedback for recruiting staff .", "sentence_id": 6}
+{"abstract_id": "24888266", "label": "conclusions", "text": "The ROMIO study aims to establish efficient methods to undertake a main trial of minimally invasive surgery versus open surgery for esophageal cancer .", "sentence_id": 7}
+{"abstract_id": "24907722", "label": "objective", "text": "Posttransplant anemia is associated with an increased risk of congestive heart failure , left ventricular hypertrophy , and death .", "sentence_id": 0}
+{"abstract_id": "24907722", "label": "objective", "text": "The purpose of this study was to evaluate the effect of long-acting erythropoietin-stimulating agents on anemia after kidney transplant .", "sentence_id": 1}
+{"abstract_id": "24907722", "label": "methods", "text": "In @ kidney transplant recipients , @ anemic patients ( @ % ) with stable graft function were followed at the Hamed Al-Essa Organ Transplant Centre ( Kuwait ) and were assessed for anemia .", "sentence_id": 2}
+{"abstract_id": "24907722", "label": "methods", "text": "We enrolled @ patients into this open-label study in @ groups : group @ had treatment with darbepoetin alfa ( @ patients ) and group @ had continuous erythropoietin receptor activator ( @ patients ) .", "sentence_id": 3}
+{"abstract_id": "24907722", "label": "results", "text": "Patient age correlated negatively with serum iron level .", "sentence_id": 4}
+{"abstract_id": "24907722", "label": "results", "text": "Serum ferritin correlated negatively with hemoglobin level @ months after transplant but not at time of transplant .", "sentence_id": 5}
+{"abstract_id": "24907722", "label": "results", "text": "Most patients were women who received their grafts from male donors .", "sentence_id": 6}
+{"abstract_id": "24907722", "label": "results", "text": "The @ groups were comparable in frequency of rejection and mean hemoglobin and serum albumin levels at @ , @ , @ , and @ months after transplant .", "sentence_id": 7}
+{"abstract_id": "24907722", "label": "results", "text": "There was no difference between the @ groups in renal function ( estimated glomerular filtration rate ) ; posttransplant complications such as new-onset diabetes after transplant , hypertension , serious bacterial infections , or patient and graft outcomes .", "sentence_id": 8}
+{"abstract_id": "24907722", "label": "conclusions", "text": "Anemia is an important problem after kidney transplant , and iron use is suboptimal in kidney transplant recipients .", "sentence_id": 9}
+{"abstract_id": "24907722", "label": "conclusions", "text": "Darbepoetin alfa and continuous erythropoietin receptor activator had comparable positive results .", "sentence_id": 10}
+{"abstract_id": "25541155", "label": "background", "text": "This study evaluates persistence and severity of docetaxel-induced neuropathy ( peripheral neuropathy ( PN ) ) and impact on health related quality of life in survivors from early-stage breast cancer .", "sentence_id": 0}
+{"abstract_id": "25541155", "label": "methods", "text": "One thousand and thirty-one patients with early-stage breast cancer , who received at least one cycle of docetaxel and provided information on PN during treatment , completed questionnaires on PN as an outcome ( Common Toxicity Criteria ( CTC ) scores , European Organisation for Research and Treatment of Cancer Chemotherapy-Induced Peripheral Neuropathy @ ( EORTC CIPN@ ) and EORTC Quality of Life Questionnaire ( QLQ ) - C@ ) after @-@years .", "sentence_id": 1}
+{"abstract_id": "25541155", "label": "results", "text": "Upon completion of docetaxel treatment , @ patients ( @ % ) reported PN , grades @-@ .", "sentence_id": 2}
+{"abstract_id": "25541155", "label": "results", "text": "PN persisted for @-@years among @ ( @ % ) while PN regressed to grades @-@ among @ ( @ % ) .", "sentence_id": 3}
+{"abstract_id": "25541155", "label": "results", "text": "Among @ patients ( @ % ) without PN , @ ( @ % ) developed PN @-@years later while @ ( @ % ) stayed free from PN .", "sentence_id": 4}
+{"abstract_id": "25541155", "label": "results", "text": "Significant risk factors for persistent PN were age @ ( p = @ ) , maximum grade of PN during docetaxel treatment ( p < @ ) , persistent muscle and joint pain ( p < @ ) , stomatitis ( p = @ ) and fatigue ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25541155", "label": "results", "text": "Persistent PN had a significant negative correlation with health-related quality of life ( HRQOL ) , functional scales and symptom scales .", "sentence_id": 6}
+{"abstract_id": "25541155", "label": "conclusions", "text": "Overall , @ % of breast cancer survivors treated with docetaxel report PN @-@years after treatment with a significant negative impact on HRQOL .", "sentence_id": 7}
+{"abstract_id": "24665014", "label": "background", "text": "A multivariable training has a positive impact on balance skills and risk of injury .", "sentence_id": 0}
+{"abstract_id": "24665014", "label": "background", "text": "To date the effect of this training using the Nintendo Wii balance board in sportive people has not yet been investigated .", "sentence_id": 1}
+{"abstract_id": "24665014", "label": "objective", "text": "The aim of this study was to investigate whether training with the Nintendo Wii balance board can improve balance skills .", "sentence_id": 2}
+{"abstract_id": "24665014", "label": "methods", "text": "@ people were randomized into a control and an intervention group each with @ people who performed a unilateral stance test with eyes open and closed as well as the star excursion balance test before and after the intervention .", "sentence_id": 3}
+{"abstract_id": "24665014", "label": "methods", "text": "The control group completed their usual sports and the intervention group an adjunct training with the Nintendo Wii balance board for @ weeks .", "sentence_id": 4}
+{"abstract_id": "24665014", "label": "results", "text": "Adjunct Training using the Nintendo Wii Balance Board did not improve sportive people 's balance skills significantly .", "sentence_id": 5}
+{"abstract_id": "24665014", "label": "results", "text": "The intervention group , however , attained better results in the star excursion balance test , whereas the control group did not show any changes .", "sentence_id": 6}
+{"abstract_id": "24665014", "label": "results", "text": "The unilateral stance tests did not provide significant differences before and after training within both groups .", "sentence_id": 7}
+{"abstract_id": "24665014", "label": "conclusions", "text": "The use of the Nintendo Wii balance board should be further investigated by employing individual difficulty levels .", "sentence_id": 8}
+{"abstract_id": "24723218", "label": "objective", "text": "Although some studies suggest that art therapy may be useful in the treatment of negative symptoms of schizophrenia , a recent large trial of group art therapy found no clinical advantage over standard care , but the study population was heterogeneous and uptake of the intervention was poor .", "sentence_id": 0}
+{"abstract_id": "24723218", "label": "objective", "text": "This study aimed to investigate whether art therapy was more effective for specific subgroups of patients .", "sentence_id": 1}
+{"abstract_id": "24723218", "label": "methods", "text": "Secondary analysis of data from a randomised controlled trial of group art therapy as an adjunctive treatment for schizophrenia ( n = @ ) versus standard care alone ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24723218", "label": "methods", "text": "Positive and Negative Syndrome Scale scores at @ months were compared between trial arms .", "sentence_id": 3}
+{"abstract_id": "24723218", "label": "methods", "text": "Interaction between intervention effect and different subgroups , including those with more severe negative symptoms of schizophrenia , and those who expressed a preference for art therapy prior to randomisation , was tested using a linear mixed model .", "sentence_id": 4}
+{"abstract_id": "24723218", "label": "results", "text": "The clinical effectiveness of group art therapy did not significantly differ between participants with more or less severe negative symptoms -LSB- interaction for difference in PANSS = @ , @ % CI ( -@ to @ ) , P = @ -RSB- , or between those who did and did not express a preference for art therapy -LSB- interaction = @ , @ % CI ( -@ to @ ) , P = @ -RSB- .", "sentence_id": 5}
+{"abstract_id": "24723218", "label": "results", "text": "None of the other exploratory subgroups suggested differences in intervention effect .", "sentence_id": 6}
+{"abstract_id": "24723218", "label": "conclusions", "text": "There was no evidence of greater improvement in clinical symptoms of schizophrenia for those with more severe negative symptoms or those with a preference for art therapy .", "sentence_id": 7}
+{"abstract_id": "24723218", "label": "conclusions", "text": "Identification of patients with schizophrenia who may benefit most from group art therapy remains elusive .", "sentence_id": 8}
+{"abstract_id": "24668359", "label": "objective", "text": "To investigate the feasibility and potential efficacy of the Nintendo Wii for balance rehabilitation after stroke .", "sentence_id": 0}
+{"abstract_id": "24668359", "label": "methods", "text": "Phase II , single-blind , randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24668359", "label": "methods", "text": "Inpatient rehabilitation facility .", "sentence_id": 2}
+{"abstract_id": "24668359", "label": "methods", "text": "Thirty adults ( mean age @ ( @ ) years ) undergoing inpatient rehabilitation who were less than three months post-stroke and able to stand unsupported .", "sentence_id": 3}
+{"abstract_id": "24668359", "label": "methods", "text": "Participants were allocated to a Balance Group , using the ` Wii Fit Plus ' in standing , or Upper Limb Group , using the ` Wii Sports/Sports Resort ' in sitting .", "sentence_id": 4}
+{"abstract_id": "24668359", "label": "methods", "text": "Both groups undertook three @ minute sessions per week over two to four weeks in addition to standard care .", "sentence_id": 5}
+{"abstract_id": "24668359", "label": "methods", "text": "The primary focus was feasibility , addressed by recruitment , retention , adherence , acceptability and safety .", "sentence_id": 6}
+{"abstract_id": "24668359", "label": "methods", "text": "Efficacy was evaluated by balance , mobility and upper limb outcomes .", "sentence_id": 7}
+{"abstract_id": "24668359", "label": "results", "text": "Twenty-one percent of individuals screened were recruited and @ % ( n = @ ) of eligible people agreed to participate .", "sentence_id": 8}
+{"abstract_id": "24668359", "label": "results", "text": "Study retention and session adherence was @ % and > @ % , respectively , at two weeks ; dropping to @ % and @ % at four weeks due to early discharge .", "sentence_id": 9}
+{"abstract_id": "24668359", "label": "results", "text": "All participants reported enjoying the sessions and most felt they were beneficial .", "sentence_id": 10}
+{"abstract_id": "24668359", "label": "results", "text": "No major adverse events occurred .", "sentence_id": 11}
+{"abstract_id": "24668359", "label": "results", "text": "Wii use by the Balance Group was associated with trends for improved balance , with significantly greater improvement in outcomes including the Step Test and Wii Balance Board-derived centre of pressure scores .", "sentence_id": 12}
+{"abstract_id": "24668359", "label": "results", "text": "The Upper Limb Group had larger , non-significant changes in arm function .", "sentence_id": 13}
+{"abstract_id": "24668359", "label": "conclusions", "text": "A Wii-based approach appears feasible and promising for post-stroke balance rehabilitation .", "sentence_id": 14}
+{"abstract_id": "24668359", "label": "conclusions", "text": "A larger randomized controlled trial is recommended to further investigate efficacy .", "sentence_id": 15}
+{"abstract_id": "24807158", "label": "background", "text": "Poor prognosis patients with bulky stage III locally advanced non-small-cell lung cancer may not be offered concurrent chemoradiotherapy ( CRT ) .", "sentence_id": 0}
+{"abstract_id": "24807158", "label": "background", "text": "Following a phase III trial concerning the effect of palliative CRT in inoperable poor prognosis patients , this analysis was performed to explore how tumor size influenced survival and health-related quality of life ( HRQOL ) .", "sentence_id": 1}
+{"abstract_id": "24807158", "label": "methods", "text": "A total of @ poor prognosis patients recruited in a randomized clinical trial received four courses intravenous carboplatin day @ and oral vinorelbine day @ and @ , at @-week intervals .", "sentence_id": 2}
+{"abstract_id": "24807158", "label": "methods", "text": "The experimental arm ( N = @ ) received radiotherapy with fractionation @ Gy/@ , starting at the second chemotherapy course .", "sentence_id": 3}
+{"abstract_id": "24807158", "label": "methods", "text": "This subset study compares outcomes in patients with tumors larger than @ cm ( N = @ ) versus tumors @ cm or smaller ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "24807158", "label": "results", "text": "Among those with tumors larger than @ cm , the median overall survival in the chemotherapy versus CRT arm was @ and @ months , respectively ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24807158", "label": "results", "text": "The @-year survival was @ % and @ % , respectively ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24807158", "label": "results", "text": "Except for a temporary decline during treatment , HRQOL was maintained in the CRT arm , regardless of tumor size .", "sentence_id": 7}
+{"abstract_id": "24807158", "label": "results", "text": "Among those who did not receive CRT , patients with tumors larger than @ cm experienced a gradual decline in the HRQOL .", "sentence_id": 8}
+{"abstract_id": "24807158", "label": "results", "text": "The CRT group had significantly more esophagitis and hospitalizations because of side effects regardless of tumor size .", "sentence_id": 9}
+{"abstract_id": "24807158", "label": "conclusions", "text": "In patients with poor prognosis and inoperable locally advanced non-small-cell lung cancer , large tumor size should not be considered a negative predictive factor .", "sentence_id": 10}
+{"abstract_id": "24807158", "label": "conclusions", "text": "Except for performance status @ , patients with tumors larger than @ cm apparently benefit from CRT .", "sentence_id": 11}
+{"abstract_id": "25595177", "label": "objective", "text": "To evaluate the role of intravitreal aflibercept injection as a treatment for eyes with chronic central serous chorioretinopathy ( CSCR ) .", "sentence_id": 0}
+{"abstract_id": "25595177", "label": "methods", "text": "This prospective pilot study enrolled @ patients with chronic CSCR who received a @-month treatment regimen of intravitreal aflibercept .", "sentence_id": 1}
+{"abstract_id": "25595177", "label": "methods", "text": "Patients were followed with monthly Early Treatment of Diabetic Retinopathy Study ( ETDRS ) best-corrected visual acuity ( BCVA ) and spectral domain optical coherence tomography ( SD-OCT ) with enhanced depth imaging .", "sentence_id": 2}
+{"abstract_id": "25595177", "label": "results", "text": "All patients were men between @ and @years ( median @ ) .", "sentence_id": 3}
+{"abstract_id": "25595177", "label": "results", "text": "Subfoveal fluid was present on OCT for a median duration of @months ( range @-@months ) prior to treatment .", "sentence_id": 4}
+{"abstract_id": "25595177", "label": "results", "text": "Baseline BCVA ranged from @/@ to @/@ ( median @/@ ) with a mean of @ ( SD = @ ) ETDRS letters .", "sentence_id": 5}
+{"abstract_id": "25595177", "label": "results", "text": "No patients experienced serious ocular or systemic adverse events over the course of the study .", "sentence_id": 6}
+{"abstract_id": "25595177", "label": "results", "text": "Post-treatment BCVA ranged from @/@ to @/@ ( median @/@ ) , with a mean of @ ( SD = @ ) ETDRS letters ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25595177", "label": "results", "text": "At baseline , three patients ( @ % ) had BCVA of @/@ versus seven patients ( @ % ) at the conclusion of the study .", "sentence_id": 8}
+{"abstract_id": "25595177", "label": "results", "text": "Two patients gained at least @ ETDRS letters and no patients lost more than @ ETDRS letters .", "sentence_id": 9}
+{"abstract_id": "25595177", "label": "results", "text": "Six of @ patients ( @ % ) had complete resolution of subfoveal fluid .", "sentence_id": 10}
+{"abstract_id": "25595177", "label": "results", "text": "Mean central macular thickness decreased from @m ( SD = @m ) to @m ( SD = @m ) ( p = @ ) , and mean subfoveal fluid decreased from @m ( SD = @m ) to @m ( SD = @m ) ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25595177", "label": "results", "text": "Mean choroidal thickness decreased from @m ( SD = @m ) to @m ( SD = @m ) ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25595177", "label": "conclusions", "text": "Intravitreal aflibercept was well tolerated over a @-month treatment course for chronic CSCR .", "sentence_id": 13}
+{"abstract_id": "25595177", "label": "conclusions", "text": "No change was observed in visual acuity metrics .", "sentence_id": 14}
+{"abstract_id": "25595177", "label": "conclusions", "text": "Anatomic trends may suggest some morphological activity , but larger controlled trials are needed .", "sentence_id": 15}
+{"abstract_id": "24474383", "label": "background", "text": "Serum infliximab trough levels correlate with efficacy ; dose escalation is often beneficial in patients with Crohn 's disease who stop responding to infliximab treatment .", "sentence_id": 0}
+{"abstract_id": "24474383", "label": "objective", "text": "To carry out a post hoc analysis of A Crohn 's Disease Clinical Trial Evaluating Infliximab in a New Long-term Treatment Regimen I ( ACCENT I ) to evaluate the association between serum infliximab trough levels and C-reactive protein ( CRP ) after @weeks of induction treatment with durable sustained long-term response ( Crohn 's Disease Activity Index decrease @ points and reduction @ % from baseline ) .", "sentence_id": 1}
+{"abstract_id": "24474383", "label": "methods", "text": "ACCENT I was a multicentre , randomised , placebo-controlled study .", "sentence_id": 2}
+{"abstract_id": "24474383", "label": "methods", "text": "Week @ trough levels and CRP percentage decrease from baseline to week @ were compared between patients with and without durable sustained response through week @ .", "sentence_id": 3}
+{"abstract_id": "24474383", "label": "methods", "text": "Sensitivity and specificity were determined to predict durable sustained response .", "sentence_id": 4}
+{"abstract_id": "24474383", "label": "methods", "text": "Receiver operating characteristic ( ROC ) curves identified optimal cut-off points ; logistic regression determined ORs .", "sentence_id": 5}
+{"abstract_id": "24474383", "label": "results", "text": "After induction with @mg/kg infliximab , @ % ( @/@ ) and @ % ( @/@ ) of patients sustained week @ response to infliximab @ or @mg/kg , respectively , administered every @weeks without dose escalation , through week @ .", "sentence_id": 6}
+{"abstract_id": "24474383", "label": "results", "text": "Median week @ trough levels of patients with and without durable sustained response to infliximab @mg/kg were @ and @ g/mL , respectively ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24474383", "label": "results", "text": "Optimal predictors of durable sustained response to maintenance infliximab @mg/kg were week @ trough level @ g/mL and @ % CRP decrease ( ORs ( @ % CI ) , @ ( @ to @ ) and @ ( @ to @ ) ) , respectively , in patients with raised baseline CRP ( > @ mg/L ) ; area under the ROC curve was @ for both predictors .", "sentence_id": 8}
+{"abstract_id": "24474383", "label": "results", "text": "A @ g/mL week @ infliximab serum level did not predict durable sustained response to @mg/kg maintenance infliximab .", "sentence_id": 9}
+{"abstract_id": "24474383", "label": "conclusions", "text": "Patients with durable sustained response to maintenance infliximab @mg/kg had higher postinduction trough levels than patients without durable sustained response .", "sentence_id": 10}
+{"abstract_id": "24474383", "label": "conclusions", "text": "Serum infliximab trough levels @ g/mL and @ % CRP decrease were significantly associated with durable sustained response .", "sentence_id": 11}
+{"abstract_id": "25248996", "label": "background", "text": "Intimate partner violence ( IPV ) and HIV are important and interconnected public health concerns .", "sentence_id": 0}
+{"abstract_id": "25248996", "label": "background", "text": "While it is recognized that they share common social drivers , there is limited evidence surrounding the potential of community interventions to reduce violence and HIV risk at the community level .", "sentence_id": 1}
+{"abstract_id": "25248996", "label": "background", "text": "The SASA !", "sentence_id": 2}
+{"abstract_id": "25248996", "label": "background", "text": "study assessed the community-level impact of SASA !", "sentence_id": 3}
+{"abstract_id": "25248996", "label": "background", "text": ", a community mobilization intervention to prevent violence and reduce HIV-risk behaviors .", "sentence_id": 4}
+{"abstract_id": "25248996", "label": "methods", "text": "From @ to @ a pair-matched cluster randomized controlled trial ( CRT ) was conducted in eight communities ( four intervention and four control ) in Kampala , Uganda .", "sentence_id": 5}
+{"abstract_id": "25248996", "label": "methods", "text": "Cross-sectional surveys of a random sample of community members , @ - to @-years old , were undertaken at baseline ( n = @,@ ) and four years post intervention implementation ( n = @,@ ) .", "sentence_id": 6}
+{"abstract_id": "25248996", "label": "methods", "text": "Six violence and HIV-related primary outcomes were defined a priori .", "sentence_id": 7}
+{"abstract_id": "25248996", "label": "methods", "text": "An adjusted cluster-level intention-to-treat analysis compared outcomes in intervention and control communities at follow-up .", "sentence_id": 8}
+{"abstract_id": "25248996", "label": "results", "text": "The intervention was associated with significantly lower social acceptance of IPV among women ( adjusted risk ratio @ , @ % confidence interval ( CI ) @ to @ ) and lower acceptance among men ( @ , @ % CI @ to @ ) ; significantly greater acceptance that a woman can refuse sex among women ( @ , @ % CI @ to @ ) and men ( @ , @ % CI @ to @ ) ; @ % lower past year experience of physical IPV among women ( @ , @ % CI @ to @ ) ; and lower levels of past year experience of sexual IPV ( @ , @ % CI @ to @ ) .", "sentence_id": 9}
+{"abstract_id": "25248996", "label": "results", "text": "Women experiencing violence in intervention communities were more likely to receive supportive community responses .", "sentence_id": 10}
+{"abstract_id": "25248996", "label": "results", "text": "Reported past year sexual concurrency by men was significantly lower in intervention compared to control communities ( @ , @ % CI @ to @ ) .", "sentence_id": 11}
+{"abstract_id": "25248996", "label": "conclusions", "text": "This is the first CRT in sub-Saharan Africa to assess the community impact of a mobilization program on the social acceptability of IPV , the past year prevalence of IPV and levels of sexual concurrency .", "sentence_id": 12}
+{"abstract_id": "25248996", "label": "conclusions", "text": "SASA !", "sentence_id": 13}
+{"abstract_id": "25248996", "label": "conclusions", "text": "achieved important community impacts , and is now being delivered in control communities and replicated in @ countries .", "sentence_id": 14}
+{"abstract_id": "26095867", "label": "background", "text": "It is uncertain whether bridging anticoagulation is necessary for patients with atrial fibrillation who need an interruption in warfarin treatment for an elective operation or other elective invasive procedure .", "sentence_id": 0}
+{"abstract_id": "26095867", "label": "background", "text": "We hypothesized that forgoing bridging anticoagulation would be noninferior to bridging with low-molecular-weight heparin for the prevention of perioperative arterial thromboembolism and would be superior to bridging with respect to major bleeding .", "sentence_id": 1}
+{"abstract_id": "26095867", "label": "methods", "text": "We performed a randomized , double-blind , placebo-controlled trial in which , after perioperative interruption of warfarin therapy , patients were randomly assigned to receive bridging anticoagulation therapy with low-molecular-weight heparin ( @ IU of dalteparin per kilogram of body weight ) or matching placebo administered subcutaneously twice daily , from @ days before the procedure until @ hours before the procedure and then for @ to @ days after the procedure .", "sentence_id": 2}
+{"abstract_id": "26095867", "label": "methods", "text": "Warfarin treatment was stopped @ days before the procedure and was resumed within @ hours after the procedure .", "sentence_id": 3}
+{"abstract_id": "26095867", "label": "methods", "text": "Follow-up of patients continued for @ days after the procedure .", "sentence_id": 4}
+{"abstract_id": "26095867", "label": "methods", "text": "The primary outcomes were arterial thromboembolism ( stroke , systemic embolism , or transient ischemic attack ) and major bleeding .", "sentence_id": 5}
+{"abstract_id": "26095867", "label": "results", "text": "In total , @ patients were enrolled , with @ assigned to receive no bridging therapy and @ assigned to receive bridging therapy .", "sentence_id": 6}
+{"abstract_id": "26095867", "label": "results", "text": "The incidence of arterial thromboembolism was @ % in the no-bridging group and @ % in the bridging group ( risk difference , @ percentage points ; @ % confidence interval -LSB- CI -RSB- , -@ to @ ; P = @ for noninferiority ) .", "sentence_id": 7}
+{"abstract_id": "26095867", "label": "results", "text": "The incidence of major bleeding was @ % in the no-bridging group and @ % in the bridging group ( relative risk , @ ; @ % CI , @ to @ ; P = @ for superiority ) .", "sentence_id": 8}
+{"abstract_id": "26095867", "label": "conclusions", "text": "In patients with atrial fibrillation who had warfarin treatment interrupted for an elective operation or other elective invasive procedure , forgoing bridging anticoagulation was noninferior to perioperative bridging with low-molecular-weight heparin for the prevention of arterial thromboembolism and decreased the risk of major bleeding .", "sentence_id": 9}
+{"abstract_id": "26095867", "label": "conclusions", "text": "( Funded by the National Heart , Lung , and Blood Institute of the National Institutes of Health ; BRIDGE ClinicalTrials.gov number , NCT@ . )", "sentence_id": 10}
+{"abstract_id": "25711323", "label": "objective", "text": "The Strategic Timing of AntiRetroviral Treatment ( START ) trial has recruited antiretroviral-nave individuals with high CD@ cell counts from all regions of the world .", "sentence_id": 0}
+{"abstract_id": "25711323", "label": "objective", "text": "We describe the distribution of cardiovascular disease ( CVD ) risk factors , overall and by geographical region , at study baseline .", "sentence_id": 1}
+{"abstract_id": "25711323", "label": "methods", "text": "The distribution of CVD risk factors was assessed and compared by geographical region among START participants who had a baseline electrocardiogram ( n = @ ; North America , @ % ; Europe/Australia/Israel , @ % ; South America , @ % ; Asia , @ % ; Africa , @ % ; median age @ years ; @ % female ) .", "sentence_id": 2}
+{"abstract_id": "25711323", "label": "results", "text": "About @ % ( n = @ ) of the participants had at least one CVD risk factor and @ % ( n = @ ) had two or more .", "sentence_id": 3}
+{"abstract_id": "25711323", "label": "results", "text": "The most common CVD risk factors were current smoking ( @ % ) , hypertension ( @ % ) and obesity ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "25711323", "label": "results", "text": "There were significant differences in the prevalence of CVD risk factors among geographical regions .", "sentence_id": 5}
+{"abstract_id": "25711323", "label": "results", "text": "The prevalence of at least one risk factor across regions was as follows : North America , @ % ; Europe/Australia/Israel , @ % ; South America , @ % ; Asia , @ % ; Africa , @ % ( P-value < @ ) .", "sentence_id": 6}
+{"abstract_id": "25711323", "label": "results", "text": "Significant regional differences were also observed when risk factors were used as part of the Framingham and Data Collection on Adverse events of Anti-HIV Drugs ( D : A :D ) risk scores or used to define a favourable risk profile .", "sentence_id": 7}
+{"abstract_id": "25711323", "label": "conclusions", "text": "CVD risk factors are common among START participants , and their distribution varies by geographical region .", "sentence_id": 8}
+{"abstract_id": "25711323", "label": "conclusions", "text": "Better understanding of how and why CVD risk factors develop in people with HIV infection and their geographical distributions could shed light on appropriate strategies for CVD prevention and may inform the interpretation of the results of START , as CVD is expected to be a major fraction of the primary endpoints observed .", "sentence_id": 9}
+{"abstract_id": "24341820", "label": "background", "text": "This randomized controlled trial aimed to evaluate whether the serum procalcitonin ( PCT ) level can be utilized to guide the use of antibiotics in the treatment of acute exacerbations of asthma .", "sentence_id": 0}
+{"abstract_id": "24341820", "label": "methods", "text": "A total of @ consecutive patients with suspected asthma attacks from February @ to July @ participated in this study .", "sentence_id": 1}
+{"abstract_id": "24341820", "label": "methods", "text": "@ patients completed the study .", "sentence_id": 2}
+{"abstract_id": "24341820", "label": "methods", "text": "Serum PCT levels , and other inflammatory biomarkers of all patients were measured .", "sentence_id": 3}
+{"abstract_id": "24341820", "label": "methods", "text": "In addition to the standard treatment , the control group received antibiotics according to the attending physicians ' discretions , while the patients in the PCT group were treated with antibiotics according to serum PCT concentrations .", "sentence_id": 4}
+{"abstract_id": "24341820", "label": "methods", "text": "Antibiotics usage was strongly discouraged when the PCT concentration was below @ g/L ; discouraged when the PCT concentration was between @ g/L and @ g/L ; or encouraged when the PCT concentration was above @ g/L .", "sentence_id": 5}
+{"abstract_id": "24341820", "label": "methods", "text": "The primary endpoint was the determination of antibiotics usage .", "sentence_id": 6}
+{"abstract_id": "24341820", "label": "methods", "text": "The second endpoints included the diagnostic accuracy of PCT and other laboratory biomarkers the effectiveness of asthma control , secondary ED visits , hospital re-admissions , repeated needs for steroids or dosage increase , needs for antibiotics , WBC count , PCT levels and FEV@ % .", "sentence_id": 7}
+{"abstract_id": "24341820", "label": "results", "text": "At baseline , two groups were identical regarding clinical , laboratory and symptom score .", "sentence_id": 8}
+{"abstract_id": "24341820", "label": "results", "text": "Probability of the antibiotics usage in the PCT group ( @ % ) was lower than that in the control group ( @ % ) ( @ = @ , p < @ .", "sentence_id": 9}
+{"abstract_id": "24341820", "label": "results", "text": "RR = @ , @ % CI @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24341820", "label": "results", "text": "PCT and IL-@ showed good diagnostic significance for bacterial asthma ( r = @ , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24341820", "label": "results", "text": "The degrees of asthma control in patients were categorized to three levels and were comparable between the two groups at the six weeks follow-up period ( @ = @ , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24341820", "label": "results", "text": "There were no significant difference regarding other secondary outcomes ( p > @ ) .", "sentence_id": 13}
+{"abstract_id": "24341820", "label": "conclusions", "text": "The serum PCT concentration can be used to effectively determine whether the acute asthma patients have bacterial infections in the respiratory tract , and to guide the use of antibiotics in the treatment of acute asthma exacerbations , which may substantially reduce unnecessary antibiotic use without compromising the therapeutic outcomes .", "sentence_id": 14}
+{"abstract_id": "25400162", "label": "objective", "text": "The SYMPLICITY HTN-@ randomized , blinded , sham-controlled trial confirmed the safety of renal denervation ( RDN ) , but did not meet its primary efficacy endpoint .", "sentence_id": 0}
+{"abstract_id": "25400162", "label": "objective", "text": "Prior RDN studies have demonstrated significant and durable reductions in blood pressure .", "sentence_id": 1}
+{"abstract_id": "25400162", "label": "objective", "text": "This analysis investigated factors that may help explain these disparate results .", "sentence_id": 2}
+{"abstract_id": "25400162", "label": "results", "text": "Patients with resistant hypertension were randomized @ : @ to RDN ( n = @ ) or sham ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25400162", "label": "results", "text": "The primary endpoint was the difference in office systolic blood pressure ( SBP ) change at @ months .", "sentence_id": 4}
+{"abstract_id": "25400162", "label": "results", "text": "A multivariable analysis identified predictors of SBP change .", "sentence_id": 5}
+{"abstract_id": "25400162", "label": "results", "text": "Additional analyses examined the influence of medication changes , results in selected subgroups and procedural factors .", "sentence_id": 6}
+{"abstract_id": "25400162", "label": "results", "text": "Between randomization and the @-month endpoint , @ % of patients underwent medication changes .", "sentence_id": 7}
+{"abstract_id": "25400162", "label": "results", "text": "Predictors of office SBP reduction at @ months were baseline office SBP @ mmHg , aldosterone antagonist use , and non-use of vasodilators ; number of ablations was a predictor in the RDN group .", "sentence_id": 8}
+{"abstract_id": "25400162", "label": "results", "text": "Non-African-American patients receiving RDN had a significantly greater change in office SBP than those receiving sham ; -@ @ vs. -@ @ mmHg , respectively ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25400162", "label": "results", "text": "Greater reductions in office and ambulatory SBP , and heart rate were observed with a higher number of ablations and energy delivery in a four-quadrant pattern .", "sentence_id": 10}
+{"abstract_id": "25400162", "label": "conclusions", "text": "Post hoc analyses , although derived from limited patient cohorts , reveal several potential confounding factors that may partially explain the unexpected blood pressure responses in both the sham control and RDN groups .", "sentence_id": 11}
+{"abstract_id": "25400162", "label": "conclusions", "text": "These hypothesis-generating data further inform the design of subsequent research to evaluate the potential role of RDN in the treatment of resistant hypertension .", "sentence_id": 12}
+{"abstract_id": "25400162", "label": "conclusions", "text": "CLINICALTRIALS.GOV IDENTIFIER : NCT@ .", "sentence_id": 13}
+{"abstract_id": "24424141", "label": "objective", "text": "To test the hypothesis that patients with soft tissue changes related to superficial venous insufficiency ( SVI ) have greater benefits from treatment than those with only symptomatic varicose veins .", "sentence_id": 0}
+{"abstract_id": "24424141", "label": "background", "text": "A commonly held view is that SVI is only a minor ailment , yet randomized clinical trials ( RCTs ) show that treatment improves quality of life ( QoL ) and is cost-effective .", "sentence_id": 1}
+{"abstract_id": "24424141", "label": "background", "text": "In an effort to curb the treatment costs of this common disorder , rationing is applied in many health care systems , often limiting the reimbursement of treatment to those with soft tissue changes .", "sentence_id": 2}
+{"abstract_id": "24424141", "label": "methods", "text": "This cohort study draws its data from an interventional RCT .", "sentence_id": 3}
+{"abstract_id": "24424141", "label": "methods", "text": "After informed consent , consecutive patients with symptomatic unilateral SVI were randomized to receive surgical ligation and stripping or endovenous laser ablation .", "sentence_id": 4}
+{"abstract_id": "24424141", "label": "methods", "text": "This analysis differentially studies the outcomes of patients with simple varicose veins ( C@ : n = @ ) and soft tissue complications ( C@-@ : n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24424141", "label": "methods", "text": "Effectiveness outcomes measured up to @ year included the following : Qol -LSB- short form @ ( SF@ ) , EuroQol , and the Aberdeen Varicose Veins Questionnaire -RSB- , clinical recurrence , and the need for secondary procedures .", "sentence_id": 6}
+{"abstract_id": "24424141", "label": "methods", "text": "Multivariable regression analysis was used to control for potential confounding factors .", "sentence_id": 7}
+{"abstract_id": "24424141", "label": "results", "text": "Both groups saw significant improvements in QoL .", "sentence_id": 8}
+{"abstract_id": "24424141", "label": "results", "text": "All improvements were equal between groups apart from the SF@ domain of Bodily Pain , where C@ saw an improvement of @ -LSB- @ % confidence interval ( CI ) : @-@ @ -RSB- points over C@-@ participants ( P = @ ) , who also suffered more recurrence -LSB- odds ratio ( OR ) = @ , @ % CI : @-@ @ , P = @ -RSB- and required more secondary procedures ( OR = @ , @ % CI : @-@ @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24424141", "label": "conclusions", "text": "This study suggests that rationing by clinical severity contradicts the evidence .", "sentence_id": 10}
+{"abstract_id": "24424141", "label": "conclusions", "text": "Delaying treatment until the development of skin damage leads to a degree of irreversible morbidity and greater recurrence .", "sentence_id": 11}
+{"abstract_id": "25867906", "label": "objective", "text": "To determine whether addition of an electronic sepsis evaluation and management tool to electronic sepsis alerting improves compliance with treatment guidelines and clinical outcomes in septic ICU patients .", "sentence_id": 0}
+{"abstract_id": "25867906", "label": "methods", "text": "A pragmatic randomized trial .", "sentence_id": 1}
+{"abstract_id": "25867906", "label": "methods", "text": "Medical and surgical ICUs of an academic , tertiary care medical center .", "sentence_id": 2}
+{"abstract_id": "25867906", "label": "methods", "text": "Four hundred and seven patients admitted during a @-month period to the medical or surgical ICU with a diagnosis of sepsis established at the time of admission or in response to an electronic sepsis alert .", "sentence_id": 3}
+{"abstract_id": "25867906", "label": "methods", "text": "Patients were randomized to usual care or the availability of an electronic tool capable of importing , synthesizing , and displaying sepsis-related data from the medical record , using logic rules to offer individualized evaluations of sepsis severity and response to therapy , informing users about evidence-based guidelines , and facilitating rapid order entry .", "sentence_id": 4}
+{"abstract_id": "25867906", "label": "results", "text": "There was no difference between the electronic tool ( @ patients ) and usual care ( @ patients ) with regard to the primary outcome of time to completion of all indicated Surviving Sepsis Campaign @-hour Sepsis Resuscitation Bundle elements ( hazard ratio , @ ; @ % CI , @-@ @ ; p = @ ) or time to completion of each element individually .", "sentence_id": 5}
+{"abstract_id": "25867906", "label": "results", "text": "ICU mortality , ICU-free days , and ventilator-free days did not differ between intervention and control .", "sentence_id": 6}
+{"abstract_id": "25867906", "label": "results", "text": "Providers used the tool to enter orders in only @ % of available cases .", "sentence_id": 7}
+{"abstract_id": "25867906", "label": "conclusions", "text": "A comprehensive electronic sepsis evaluation and management tool is feasible and safe but did not influence guideline compliance or clinical outcomes , perhaps due to low utilization .", "sentence_id": 8}
+{"abstract_id": "24406033", "label": "background", "text": "Colorectal cancer is a major public health problem .", "sentence_id": 0}
+{"abstract_id": "24406033", "label": "background", "text": "There is growing support for colorectal cancer survivors who are experiencing problems after cancer treatment to engage in self-management programs to reduce symptom distress .", "sentence_id": 1}
+{"abstract_id": "24406033", "label": "background", "text": "However , there is inconclusive evidence as to the effectiveness of such program especially in Asian region .", "sentence_id": 2}
+{"abstract_id": "24406033", "label": "objective", "text": "This study tested the effects of a six-month nurse-led self-efficacy-enhancing intervention for patients with colorectal cancer , compared with routine care over a six-month follow up .", "sentence_id": 3}
+{"abstract_id": "24406033", "label": "methods", "text": "A randomized controlled trial with repeated measures , two-group design .", "sentence_id": 4}
+{"abstract_id": "24406033", "label": "methods", "text": "Three teaching hospitals in Guangzhou , China .", "sentence_id": 5}
+{"abstract_id": "24406033", "label": "methods", "text": "One hundred and fifty-two Chinese adult patients with a diagnosis of colorectal cancer were recruited .", "sentence_id": 6}
+{"abstract_id": "24406033", "label": "methods", "text": "The intervention group ( n = @ ) received self-efficacy-enhancing intervention and the control group ( n = @ ) received standard care .", "sentence_id": 7}
+{"abstract_id": "24406033", "label": "methods", "text": "The participants were randomized into either intervention or control group after baseline measures .", "sentence_id": 8}
+{"abstract_id": "24406033", "label": "methods", "text": "The outcomes of the study ( self-efficacy , symptom distress , anxiety , depression and quality of life ) were compared at baseline , three and six months after the intervention .", "sentence_id": 9}
+{"abstract_id": "24406033", "label": "results", "text": "Sixty-eight participants in the intervention group and @ in the control group completed the study .", "sentence_id": 10}
+{"abstract_id": "24406033", "label": "results", "text": "Their mean age was @ ( SD = @ ) .", "sentence_id": 11}
+{"abstract_id": "24406033", "label": "results", "text": "Repeated measure MANOVA found that the patients in the intervention group had significant improvement in their self-efficacy ( F = @ , p = @ ) and a reduction of symptom severity ( F = @ , p = @ ) , symptom interference ( F = @ , p = @ ) , anxiety ( F = @ , p = @ ) and depression ( F = @ , p = @ ) at three and six months , compared with the control group .", "sentence_id": 12}
+{"abstract_id": "24406033", "label": "results", "text": "However , no statistically significant main effect was observed in quality of life perception between the two groups .", "sentence_id": 13}
+{"abstract_id": "24406033", "label": "conclusions", "text": "The nurse-led self-efficacy enhancing intervention was effective in promoting self-efficacy and psychological well-being in patients with colorectal cancer , compared with standard care .", "sentence_id": 14}
+{"abstract_id": "24406033", "label": "conclusions", "text": "The intervention can be incorporated into routine care .", "sentence_id": 15}
+{"abstract_id": "24406033", "label": "conclusions", "text": "Future empirical work is required to determine the longer term effects of the intervention .", "sentence_id": 16}
+{"abstract_id": "25491026", "label": "background", "text": "Studies that have examined the impact of a physical activity intervention on cardiometabolic risk factors have yielded conflicting results .", "sentence_id": 0}
+{"abstract_id": "25491026", "label": "background", "text": "The objective of this study was to assess the impact of a standardized physical activity program on adiposity and cardiometabolic risk factors in schoolchildren .", "sentence_id": 1}
+{"abstract_id": "25491026", "label": "methods", "text": "Cluster randomized trial study of @ schoolchildren , @-@ years , from @ public schools in the Province of Cuenca , Spain .", "sentence_id": 2}
+{"abstract_id": "25491026", "label": "methods", "text": "The intervention ( MOVI-@ ) consisted of play-based and non-competitive activities .", "sentence_id": 3}
+{"abstract_id": "25491026", "label": "methods", "text": "MOVI-@ was conducted during two @-minute sessions on weekdays and one @-minute session on Saturday mornings every week between September @ and May @ .", "sentence_id": 4}
+{"abstract_id": "25491026", "label": "methods", "text": "We measured changes in adiposity ( overweight/obesity prevalence , body mass index -LSB- BMI -RSB- , triceps skinfold thickness -LSB- TST -RSB- , body fat % , fat-free mass , waist circumference ) and other cardiometabolic risk factors ( LDL-cholesterol , triglycerides/HDL-cholesterol ratio , insulin , C-reactive protein and blood pressure ) .", "sentence_id": 5}
+{"abstract_id": "25491026", "label": "methods", "text": "The analyses used mixed regression models to adjust for baseline covariates under cluster randomization .", "sentence_id": 6}
+{"abstract_id": "25491026", "label": "results", "text": "Among girls , we found a reduction of adiposity in intervention versus control schools , with a decrease in TST ( -@ mm ; @ % confidence interval -LSB- CI -RSB- -@ to -@ ) , body fat % ( -@ % ; @ % CI -@ to -@ ) , waist circumference ( -@ cm ; @ % CI -@ to -@ ) , and an increase in fat-free mass ( @ kg ; @ % CI @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25491026", "label": "results", "text": "The intervention also led to lower serum LDL-cholesterol and insulin levels .", "sentence_id": 8}
+{"abstract_id": "25491026", "label": "results", "text": "Among boys , a reduction in waist circumference ( -@ cm ; @ % CI -@ to -@ ; P = @ ) , and an increase in fat-free mass ( @ kg ; @ % CI @ to @ ; P = @ ) was associated with the intervention versus control schools .", "sentence_id": 9}
+{"abstract_id": "25491026", "label": "results", "text": "The prevalence of overweight/obesity or underweight , BMI , and other cardiometabolic risk factors was not modified by the intervention .", "sentence_id": 10}
+{"abstract_id": "25491026", "label": "results", "text": "No important adverse events were registered .", "sentence_id": 11}
+{"abstract_id": "25491026", "label": "conclusions", "text": "An extracurricular intervention of non-competitive physical activity during an academic year , targeting all schoolchildren regardless of body weight , is a safe and effective measure to reduce adiposity in both genders and to improve cardiometabolic risk profile in girls .", "sentence_id": 12}
+{"abstract_id": "24220935", "label": "objective", "text": "We investigated potential biomarkers of efficacy in a phase III trial of sunitinib versus interferon-alpha ( IFN - ) , first-line in metastatic renal cell carcinoma ( mRCC ) , by analyzing plasma levels of vascular endothelial growth factor ( VEGF ) - A , VEGF-C , soluble VEGF receptor-@ ( sVEGFR-@ ) and interleukin ( IL ) -@ .", "sentence_id": 0}
+{"abstract_id": "24220935", "label": "methods", "text": "Seven hundred and fifty mRCC patients were randomized to oral sunitinib @ mg/day in repeated cycles of a @-week on/@-week off schedule or IFN - @ million units subcutaneously thrice weekly .", "sentence_id": 1}
+{"abstract_id": "24220935", "label": "methods", "text": "Plasma samples collected from a subset of @ patients on days @ and @ of cycles @-@ and at end of treatment were analyzed by ELISA .", "sentence_id": 2}
+{"abstract_id": "24220935", "label": "results", "text": "Baseline characteristics of biomarker-evaluated patients in sunitinib ( N = @ ) and IFN - ( N = @ ) arms were comparable to their respective intent-to-treat populations .", "sentence_id": 3}
+{"abstract_id": "24220935", "label": "results", "text": "By univariate Cox regression analysis , low baseline soluble protein levels were associated with lower risk of progression/death ( all P < @ ) : in both treatment arms , baseline VEGF-A and IL-@ were associated with overall survival ( OS ) and baseline VEGF-C with progression-free survival ( PFS ) ; in the sunitinib arm , baseline VEGF-A was associated with PFS and baseline sVEGFR-@ with PFS and OS ; in the IFN - arm , baseline IL-@ was associated with PFS .", "sentence_id": 4}
+{"abstract_id": "24220935", "label": "results", "text": "In multivariate analysis , baseline sVEGFR-@ and IL-@ remained independent predictors of OS in the sunitinib arm , while no independent predictors of outcome remained in the IFN - arm .", "sentence_id": 5}
+{"abstract_id": "24220935", "label": "results", "text": "Pharmacodynamic changes were not associated with PFS or OS for any plasma protein investigated .", "sentence_id": 6}
+{"abstract_id": "24220935", "label": "conclusions", "text": "Our findings suggest that , in mRCC , baseline VEGF-A and IL-@ may have prognostic value , while baseline sVEGFR-@ may predict sunitinib efficacy .", "sentence_id": 7}
+{"abstract_id": "24231639", "label": "objective", "text": "The aim of the study was to evaluate the relation between nutritional intake ( kilocalories , protein ) and weight and length growth in preterm infants , and to describe their metabolic tolerance with a focus on those with high protein intake ( @ g kg ( -@ ) day ( -@ ) ) .", "sentence_id": 0}
+{"abstract_id": "24231639", "label": "methods", "text": "Secondary analysis of data from appropriate-for-gestational age preterm infants in a @-day randomized clinical trial that evaluated growth , tolerance , and safety of a new ultraconcentrated liquid human milk fortifier ( original study n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24231639", "label": "methods", "text": "This subset of @ infants had complete growth and nutrition data and met criteria for the original study 's `` efficacy analysis '' ( eg , > @ % of kilocalorie intake from study diet ) .", "sentence_id": 2}
+{"abstract_id": "24231639", "label": "methods", "text": "Nutritional intake was estimated , not actual .", "sentence_id": 3}
+{"abstract_id": "24231639", "label": "methods", "text": "Regressions were used to test cumulative kilocalories and protein as the predictors of @-day change in weight and length z scores ( growth status ) , and to evaluate protein tolerance .", "sentence_id": 4}
+{"abstract_id": "24231639", "label": "results", "text": "Average intake was @ @ kcal kg ( -@ ) day ( -@ ) and @ @ g protein kg ( -@ ) day ( -@ ) , with @ @ g kg ( -@ ) day ( -@ ) and @ @ cm/week growth for @ days .", "sentence_id": 5}
+{"abstract_id": "24231639", "label": "results", "text": "Cumulative total kilocalories and protein were significant predictors of improved length z score ( P = @ , @ ) but not weight z score change .", "sentence_id": 6}
+{"abstract_id": "24231639", "label": "results", "text": "Regression models indicated that protein not kilocalories explained the improvement in length z score , with protein explaining @ % of the variability .", "sentence_id": 7}
+{"abstract_id": "24231639", "label": "results", "text": "The high protein group averaged @ to @ g kg ( -@ ) day ( -@ ) ( n = @ ) .", "sentence_id": 8}
+{"abstract_id": "24231639", "label": "results", "text": "Protein tolerance was adequate for all of the study infants based on metabolic measures ( blood urea nitrogen , serum carbon dioxide , pH ) .", "sentence_id": 9}
+{"abstract_id": "24231639", "label": "conclusions", "text": "Higher cumulative protein intake was tolerated and overall lessened the commonly occurring decline in the length but not weight growth status in a @-day study of preterm infants .", "sentence_id": 10}
+{"abstract_id": "24247211", "label": "objective", "text": "The objective of this study was to investigate whether ingestion of fructose and fructans ( such as inulin ) can exacerbate irritable bowel syndrome ( IBS ) symptoms .", "sentence_id": 0}
+{"abstract_id": "24247211", "label": "objective", "text": "The aim was to better understand the origin of these symptoms by magnetic resonance imaging ( MRI ) of the gut .", "sentence_id": 1}
+{"abstract_id": "24247211", "label": "methods", "text": "A total of @ healthy volunteers participated in a four-way , randomized , single-blind , crossover study in which they consumed @ml of water containing @g of either glucose , fructose , inulin , or a @:@ mixture of @g glucose and @g fructose .", "sentence_id": 2}
+{"abstract_id": "24247211", "label": "methods", "text": "MRI scans were performed hourly for @h , assessing the volume of gastric contents , small bowel water content ( SBWC ) , and colonic gas .", "sentence_id": 3}
+{"abstract_id": "24247211", "label": "methods", "text": "Breath hydrogen ( H@ ) was measured and symptoms recorded after each scan .", "sentence_id": 4}
+{"abstract_id": "24247211", "label": "results", "text": "Data are reported as mean ( s.d. ) ( @ % CI ) when normally distributed and median ( range ) when not .", "sentence_id": 5}
+{"abstract_id": "24247211", "label": "results", "text": "Fructose increased area under the curve ( AUC ) from @-@h of SBWC to @ ( @ ) l/min , significantly greater than for glucose at @ ( @-@ ) l/min ( P < @ ) , whereas AUC SBWC after inulin , @ ( @-@ ) l/min , was no different from that after glucose .", "sentence_id": 6}
+{"abstract_id": "24247211", "label": "results", "text": "Adding glucose to fructose decreased AUC SBWC to @ ( @ ) l/min ( P = @ ) vs. fructose .", "sentence_id": 7}
+{"abstract_id": "24247211", "label": "results", "text": "Inulin substantially increased AUC colonic gas to @ ( @ ) l/min , significantly greater than glucose and glucose + fructose ( both P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24247211", "label": "results", "text": "Breath H@ rose more with inulin than with fructose .", "sentence_id": 9}
+{"abstract_id": "24247211", "label": "results", "text": "Glucose when combined with fructose significantly reduced breath H@ by @,@ ( @,@-@ ,@ ) p.p.m. / min relative to fructose alone ( P < @ , n = @ ) .", "sentence_id": 10}
+{"abstract_id": "24247211", "label": "conclusions", "text": "Fructose but not inulin distends the small bowel with water .", "sentence_id": 11}
+{"abstract_id": "24247211", "label": "conclusions", "text": "Adding glucose to fructose reduces the effect of fructose on SBWC and breath hydrogen .", "sentence_id": 12}
+{"abstract_id": "24247211", "label": "conclusions", "text": "Inulin distends the colon with gas more than fructose , but causes few symptoms in healthy volunteers .", "sentence_id": 13}
+{"abstract_id": "25488963", "label": "objective", "text": "This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma ( HCC ) without prior systemic therapy .", "sentence_id": 0}
+{"abstract_id": "25488963", "label": "methods", "text": "Patients were randomly assigned in a @:@ ratio to linifanib @ mg once daily or sorafenib @ mg twice daily .", "sentence_id": 1}
+{"abstract_id": "25488963", "label": "methods", "text": "Patients were stratified by region ( Outside Asia , Japan , and rest of Asia ) , Eastern Cooperative Oncology Group performance score ( ECOG PS ; @ or @ ) , vascular invasion or extrahepatic spread ( yes or no ) , and hepatitis B virus ( HBV ) infection ( yes or no ) .", "sentence_id": 2}
+{"abstract_id": "25488963", "label": "methods", "text": "The primary end point of the study was overall survival ( OS ) .", "sentence_id": 3}
+{"abstract_id": "25488963", "label": "methods", "text": "Secondary end points were time to progression ( TTP ) and objective response rate ( ORR ) per RECIST v@ @ .", "sentence_id": 4}
+{"abstract_id": "25488963", "label": "results", "text": "We randomly assigned @,@ patients ( median age , @ years ; Asian , @ % ; ECOG PS @ , @ % ; HBV , @ % ; vascular invasion or extrahepatic spread , @ % ) .", "sentence_id": 5}
+{"abstract_id": "25488963", "label": "results", "text": "Median OS was @ months on the linifanib arm ( @ % CI , @ to @ ) and @ months on the sorafenib arm ( @ % CI , @ to @ ; hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25488963", "label": "results", "text": "For prespecified stratification subgroups , OS HRs ranged from @ to @ and the @ % CI contained @ .", "sentence_id": 7}
+{"abstract_id": "25488963", "label": "results", "text": "Median TTP was @ months on the linifanib arm ( @ % CI , @ to @ ) and @ months on the sorafenib arm ( @ % CI , @ to @ ; HR , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25488963", "label": "results", "text": "Best response rate was @ % on the linifanib arm versus @ % on the sorafenib arm .", "sentence_id": 9}
+{"abstract_id": "25488963", "label": "results", "text": "Grade @/@ adverse events ( AEs ) ; serious AEs ; and AEs leading to discontinuation , dose interruption , and reduction were more frequent with linifanib ( all P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25488963", "label": "conclusions", "text": "Linifanib and sorafenib had similar OS in advanced HCC .", "sentence_id": 11}
+{"abstract_id": "25488963", "label": "conclusions", "text": "Predefined superiority and noninferiority OS boundaries were not met for linifanib and the study failed to meet the primary end point .", "sentence_id": 12}
+{"abstract_id": "25488963", "label": "conclusions", "text": "TTP and ORR favored linifanib ; safety results favored sorafenib .", "sentence_id": 13}
+{"abstract_id": "24443804", "label": "background", "text": "While many of the commonly used conservative treatments for knee osteoarthritis ( OA ) have been recognized to be effective , there is still insufficient evidence available .", "sentence_id": 0}
+{"abstract_id": "24443804", "label": "background", "text": "Among the pharmacological treatments for knee OA , oral non-steroidal anti-inflammatory drugs ( NSAIDs ) act rapidly and are recommended for the management of OA .", "sentence_id": 1}
+{"abstract_id": "24443804", "label": "background", "text": "However , frequent and serious adverse effects of NSAIDs have been recognized .", "sentence_id": 2}
+{"abstract_id": "24443804", "label": "background", "text": "Intra-articular injections of hyaluronic acid ( IA-HA ) for the treatment of knee OA have been shown to reduce pain and improve joint function .", "sentence_id": 3}
+{"abstract_id": "24443804", "label": "background", "text": "However , there has been no qualified direct comparison study of the efficacy and safety between IA-HA and NSAIDs for patients with knee OA .", "sentence_id": 4}
+{"abstract_id": "24443804", "label": "background", "text": "The aim of this study was to clarify the efficacy and safety of early-phase IA-HA in comparison to those of NSAIDs for patients with knee OA .", "sentence_id": 5}
+{"abstract_id": "24443804", "label": "methods", "text": "This multicenter , randomized , open-label , parallel-group , non-inferiority comparison study with an oral NSAID involved a total of @ patients with knee OA .", "sentence_id": 6}
+{"abstract_id": "24443804", "label": "methods", "text": "An independent , computer-generated randomization sequence was used to randomly assign patients in a @:@ ratio to NSAIDs three times per day for five weeks ( n = @ ) or IA-HA once a week for five weeks ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "24443804", "label": "methods", "text": "The primary endpoint was the percentage change in the patient-oriented outcome measure for knee OA , the Japanese Knee Osteoarthritis Measure ( JKOM ) score .", "sentence_id": 8}
+{"abstract_id": "24443804", "label": "methods", "text": "All patients were questioned regarding any adverse events during treatment .", "sentence_id": 9}
+{"abstract_id": "24443804", "label": "methods", "text": "The full analysis set ( FAS ) was used for analysis .", "sentence_id": 10}
+{"abstract_id": "24443804", "label": "methods", "text": "The margin of non-inferiority was @ % .", "sentence_id": 11}
+{"abstract_id": "24443804", "label": "results", "text": "The analyses of primary endpoint included @ patients in the IA-HA group and @ patients in the NSAID group .", "sentence_id": 12}
+{"abstract_id": "24443804", "label": "results", "text": "The difference in the percentage changes of the JKOM score between the two intervention arms ( IA-HA ; -@ % ( P < @ ) , NSAID ; -@ % ( P < @ ) ) was -@ % ( @ % confidence interval ( CI ) : -@ to @ ) , indicating IA-HA was not inferior to NSAID .", "sentence_id": 13}
+{"abstract_id": "24443804", "label": "results", "text": "The frequency of both withdrawal and adverse events in the IA-HA group were significantly lower than those in the NSAID group ( P = @ and @ , respectively ) .", "sentence_id": 14}
+{"abstract_id": "24443804", "label": "conclusions", "text": "The early efficacy of IA-HA is suggested to be not inferior to that of NSAIDs , and that the safety of the early phase of IA-HA is superior to that of NSAIDs for patients with knee OA .", "sentence_id": 15}
+{"abstract_id": "25160734", "label": "background", "text": "Two randomized intraoperative radiation therapy trials for early-stage breast cancer were recently published .", "sentence_id": 0}
+{"abstract_id": "25160734", "label": "background", "text": "The ELIOT Trial used electrons ( IOERT ) , and the TARGIT-A Trial Update used @-kV X-rays ( IORT ) .", "sentence_id": 1}
+{"abstract_id": "25160734", "label": "background", "text": "These studies were compared for similarities and differences .", "sentence_id": 2}
+{"abstract_id": "25160734", "label": "background", "text": "The results were analyzed and used to determine which patients might be suitable for single-dose treatment .", "sentence_id": 3}
+{"abstract_id": "25160734", "label": "methods", "text": "The primary sources of data were the ELIOT Trial and TARGIT-A Trial , as well as a comprehensive analysis of the peer-reviewed literature of accelerated partial breast irradiation ( APBI ) using @-kV X-rays or electrons .", "sentence_id": 4}
+{"abstract_id": "25160734", "label": "methods", "text": "Studies published or presented prior to March @ were analyzed for efficacy , patient restrictions , complications , and outcome .", "sentence_id": 5}
+{"abstract_id": "25160734", "label": "results", "text": "With a median follow-up of @ years , the @-year recurrence rates for ELIOT versus external beam radiation therapy ( EBRT ) patients were @ % and @ % , respectively , p = @ .", "sentence_id": 6}
+{"abstract_id": "25160734", "label": "results", "text": "A low-risk ELIOT group was identified with a @-year recurrence rate of @ % .", "sentence_id": 7}
+{"abstract_id": "25160734", "label": "results", "text": "With a median follow-up of @months , the @-year recurrence rates for the TARGIT-A versus EBRT patients were @ % and @ % , respectively , p = @ .", "sentence_id": 8}
+{"abstract_id": "25160734", "label": "conclusions", "text": "With @ years of median follow-up , IOERT appears to have a subset of low-risk women for whom IOERT is acceptable .", "sentence_id": 9}
+{"abstract_id": "25160734", "label": "conclusions", "text": "With @months of median follow-up the results of IORT with @-kV devices are promising , but longer follow-up data are required .", "sentence_id": 10}
+{"abstract_id": "25160734", "label": "conclusions", "text": "At the current time , single-fraction IOERT or IORT patients should be treated under strict institutional protocols .", "sentence_id": 11}
+{"abstract_id": "24369008", "label": "objective", "text": "To examine whether baseline obesity severity modifies the effects of two different , primary care-based , technology-enhanced lifestyle interventions among overweight or obese adults with prediabetes and/or metabolic syndrome .", "sentence_id": 0}
+{"abstract_id": "24369008", "label": "methods", "text": "We compared mean differences in changes from baseline to @ months in clinical measures of general and central obesity among participants randomized to usual care alone ( n = @ ) or usual care plus a coach-led group ( n = @ ) or self-directed individual ( n = @ ) intervention , stratified by baseline body mass index ( BMI ) category .", "sentence_id": 1}
+{"abstract_id": "24369008", "label": "results", "text": "Participants with baseline BMI @ + had greater reductions in mean BMI , body weight ( as percentage change ) , and waist circumference in the coach-led group intervention , compared to usual care and the self-directed individual intervention ( P < @ for all ) .", "sentence_id": 2}
+{"abstract_id": "24369008", "label": "results", "text": "In contrast , the self-directed intervention was more effective than usual care only among participants with baseline BMIs between @ @ .", "sentence_id": 3}
+{"abstract_id": "24369008", "label": "results", "text": "Mean weight loss exceeded @ % in the coach-led intervention regardless of baseline BMI category , but this was achieved only among self-directed intervention participants with baseline BMIs < @ .", "sentence_id": 4}
+{"abstract_id": "24369008", "label": "conclusions", "text": "Baseline BMI may influence behavioral weight-loss treatment effectiveness .", "sentence_id": 5}
+{"abstract_id": "24369008", "label": "conclusions", "text": "Researchers and clinicians should take an individual 's baseline BMI into account when developing or recommending lifestyle focused treatment strategy .", "sentence_id": 6}
+{"abstract_id": "24369008", "label": "conclusions", "text": "This trial is registered with ClinicalTrials.gov NCT@ .", "sentence_id": 7}
+{"abstract_id": "25326007", "label": "background", "text": "Patients ' reported opinions of the health system need to be understood in order to provide patient-centered care .", "sentence_id": 0}
+{"abstract_id": "25326007", "label": "background", "text": "We investigated determinants of women 's ratings of the quality of care during their most recent facility delivery .", "sentence_id": 1}
+{"abstract_id": "25326007", "label": "methods", "text": "We conducted a census of all deliveries in the @ weeks to @ months preceding the survey , in villages served by @ primary care clinics in rural Pwani Region , Tanzania .", "sentence_id": 2}
+{"abstract_id": "25326007", "label": "methods", "text": "Women who had delivered children in a study facility were included in this analysis ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25326007", "label": "methods", "text": "We interviewed women about demographic and obstetric factors and the quality of their obstetric care using a structured questionnaire .", "sentence_id": 4}
+{"abstract_id": "25326007", "label": "methods", "text": "We created a composite index of perceived quality from six quality questions .", "sentence_id": 5}
+{"abstract_id": "25326007", "label": "methods", "text": "We also assessed the functioning of the local health clinic using structured surveys .", "sentence_id": 6}
+{"abstract_id": "25326007", "label": "methods", "text": "We used a multi-level model to analyze factors associated with women 's rating of the quality of care during delivery .", "sentence_id": 7}
+{"abstract_id": "25326007", "label": "results", "text": "@ % of respondents rated the overall quality of care received during delivery as excellent .", "sentence_id": 8}
+{"abstract_id": "25326007", "label": "results", "text": "Women who listened to the radio daily reported lower quality composite scores ( : -@ , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25326007", "label": "results", "text": "Women who reported receiving more services in ANC had higher quality scores ( : @ , p = @ ) , as did women receiving more delivery services ( : @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25326007", "label": "results", "text": "Women who reported disrespect and abuse during delivery had significantly lower quality scores ( : -@ , p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25326007", "label": "conclusions", "text": "A woman 's expectations and prior and current experiences influence her perception of the quality of care she received .", "sentence_id": 12}
+{"abstract_id": "25326007", "label": "conclusions", "text": "Health facility characteristics did not influence ratings of overall quality .", "sentence_id": 13}
+{"abstract_id": "25326007", "label": "conclusions", "text": "Focusing on improving the process rather than inputs of service delivery during ANC visits and delivery may increase perceived quality of delivery care in low-resource settings .", "sentence_id": 14}
+{"abstract_id": "25391382", "label": "background", "text": "There is a lack of knowledge about antidementia drug treatment in community dwelling people with dementia in Germany .", "sentence_id": 0}
+{"abstract_id": "25391382", "label": "objective", "text": "To determine the frequency of treatment with antidementia drugs in patients in primary care , and the socio-demographic and clinical variables associated with antidementia drug treatment .", "sentence_id": 1}
+{"abstract_id": "25391382", "label": "methods", "text": "Present analyses are based on preliminary data from the DelpHi-trial , an ongoing GP-based , cluster-randomized , controlled intervention trial to implement and evaluate an innovative concept of collaborative dementia care management in Germany .", "sentence_id": 2}
+{"abstract_id": "25391382", "label": "methods", "text": "Our sample consists of n = @ subjects who screened positive for dementia .", "sentence_id": 3}
+{"abstract_id": "25391382", "label": "results", "text": "@ % ( n = @ ) of participants received antidementia drugs : memantine @ % ( n = @ ) ; donepezil @ % ( n = @ ) ; rivastigmine @ % ( n = @ ) ; galantamine @ % ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25391382", "label": "results", "text": "A total of @ % ( n = @ ) of the subgroup of participants with a formal dementia diagnosis received antidementia drug treatment .", "sentence_id": 5}
+{"abstract_id": "25391382", "label": "results", "text": "Approximately @ % ( n = @ ) of our sample received treatment with antidementia drugs without having a formal diagnosis .", "sentence_id": 6}
+{"abstract_id": "25391382", "label": "results", "text": "Treatment with antidementia drugs was significantly associated with more severe cognitive impairment and having a formal dementia diagnosis .", "sentence_id": 7}
+{"abstract_id": "25391382", "label": "conclusions", "text": "One in three people who screened positive for dementia in primary care received antidementia drug treatment , indicating the frequent use of this class of drugs .", "sentence_id": 8}
+{"abstract_id": "25391382", "label": "conclusions", "text": "For those with a formal dementia diagnosis , these drug treatment rates are more than triple , compared to those in nursing homes .", "sentence_id": 9}
+{"abstract_id": "24767009", "label": "background", "text": "Internet-delivered trauma-focused cognitive behavioural therapy is efficacious for PTSD ; however , no studies have investigated the roles of individual treatment components or the safety of online treatments .", "sentence_id": 0}
+{"abstract_id": "24767009", "label": "objective", "text": "To compare the efficacy and safety of an online treatment for PTSD comprised of psychoeducation , stress management , cognitive restructuring and exposure components with the equivalent protocol without the exposure components , using a randomised controlled trial design .", "sentence_id": 1}
+{"abstract_id": "24767009", "label": "methods", "text": "Sixty-six individuals were randomised to a non-exposure condition and @ to the full protocol with exposure components .", "sentence_id": 2}
+{"abstract_id": "24767009", "label": "methods", "text": "Treatment duration was @ weeks and pre - , post-treatment and three-month follow-up outcomes were analysed using a mixed linear modelling approach .", "sentence_id": 3}
+{"abstract_id": "24767009", "label": "results", "text": "Both groups achieved improvements in symptoms with no differences between groups on any primary or secondary outcome measures , diagnostic remission rates or adverse events .", "sentence_id": 4}
+{"abstract_id": "24767009", "label": "conclusions", "text": "The study included several secondary measures that have not been previously validated and treatments were not time matched in terms of number of lessons .", "sentence_id": 5}
+{"abstract_id": "24767009", "label": "conclusions", "text": "These findings indicate that trauma-focused cognitive behavioural therapy for PTSD with or without exposure components can be safe and efficacious .", "sentence_id": 6}
+{"abstract_id": "24291239", "label": "objective", "text": "Patients with genotype @ hepatitis C virus ( HCV ) infection and cirrhosis have poor response rates after @ weeks treatment with pegylated interferon and ribavirin .", "sentence_id": 0}
+{"abstract_id": "24291239", "label": "objective", "text": "Treatment for @ weeks is therefore recommended , although the benefits of this are untested .", "sentence_id": 1}
+{"abstract_id": "24291239", "label": "objective", "text": "We examined extended therapy in patients with genotype @ HCV and advanced fibrosis .", "sentence_id": 2}
+{"abstract_id": "24291239", "label": "methods", "text": "Multicentre , open labelled randomized trial comparing therapy with @ weeks pegylated interferon and ribavirin to @ weeks of the same therapy .", "sentence_id": 3}
+{"abstract_id": "24291239", "label": "results", "text": "@ patients completed the study .", "sentence_id": 4}
+{"abstract_id": "24291239", "label": "results", "text": "@ received @ weeks therapy and the SVR rate ( @ % ) did not differ from that seen in the @ patients who received @ weeks therapy ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "24291239", "label": "results", "text": "The response rates in patients with biopsy proven cirrhosis ( @ patients treated for @ weeks , @ patients treated for @ weeks ) or cirrhosis proven on imaging ( @ patients treated for @ weeks and @ patients treated for @ weeks ) were @ % in those treated for @ weeks and @ % in those treated for @ weeks .", "sentence_id": 6}
+{"abstract_id": "24291239", "label": "results", "text": "The differences were not significantly different .", "sentence_id": 7}
+{"abstract_id": "24291239", "label": "results", "text": "Treatment failure was due to relapse in the majority of patients .", "sentence_id": 8}
+{"abstract_id": "24291239", "label": "conclusions", "text": "Patients with genotype @ HCV and advanced fibrosis do not benefit from extended therapy with pegylated interferon and ribavirin .", "sentence_id": 9}
+{"abstract_id": "24689967", "label": "objective", "text": "Epidemiological research links aggression to low serum concentrations of omega-@ fatty acids , such as those found in fish oil .", "sentence_id": 0}
+{"abstract_id": "24689967", "label": "objective", "text": "However , no studies have specifically examined whether fish oil supplementation can reduce the frequency and severity of impulsive aggression in children with disruptive behavior disorders .", "sentence_id": 1}
+{"abstract_id": "24689967", "label": "methods", "text": "Children presenting with impulsive aggression and meeting research criteria for diagnosis of disruptive behavior disorders were randomized to receive either : @ ) Fish oil capsules ( @g daily ) for @ weeks followed by placebo ( identical-looking capsules ) for @ weeks ; or @ ) placebo for @ weeks , followed by fish oil for @ weeks , in a double-blind , crossover design .", "sentence_id": 2}
+{"abstract_id": "24689967", "label": "methods", "text": "Primary outcomes were the Children 's Aggression Scale and the Modified Overt Aggression Scale .", "sentence_id": 3}
+{"abstract_id": "24689967", "label": "methods", "text": "Secondary outcomes included emotional and behavioral functioning ( Strengths and Difficulties Questionnaire -LSB- SDQ -RSB- ) , hyperactivity symptoms ( Attention-Deficit/Hyperactivity Disorder -LSB- ADHD -RSB- Rating Scale ) , family functioning ( Family Assessment Device ) , and cognitive functioning ( Stop Signal Task , Trail-Making Task , and Eriksen Flanker Task ) .", "sentence_id": 4}
+{"abstract_id": "24689967", "label": "methods", "text": "Serum concentrations of omega-@ and omega-@ fatty acids were measured at baseline , and at @ and @ weeks .", "sentence_id": 5}
+{"abstract_id": "24689967", "label": "results", "text": "Twenty-one children participated ( @ % male ; mean age @ years ; range @-@ ) .", "sentence_id": 6}
+{"abstract_id": "24689967", "label": "results", "text": "Fish oil treatment increased serum concentrations of eicosapentanoic acid ( F = @ , p < @ ) and total omega-@s ( F = @ , p < @ ) , but did not influence primary ratings of aggression .", "sentence_id": 7}
+{"abstract_id": "24689967", "label": "results", "text": "In fact , a trend suggested that fish oil worsened a secondary measure of aggression ( SDQ Conduct Subscale , F = @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24689967", "label": "results", "text": "Fish oil treatment was associated with an improvement in one rating of hyperactivity ( SDQ Hyperactivity Subscale , F = @ , p < @ ) , but did not influence any other outcome measures .", "sentence_id": 9}
+{"abstract_id": "24689967", "label": "conclusions", "text": "These findings suggest that fish oil treatment does not improve aggression in children with disruptive behavior disorders .", "sentence_id": 10}
+{"abstract_id": "25486542", "label": "objective", "text": "To compare outcomes of illuminated microcatheter-assisted circumferential trabeculotomy vs combined mitomycin C-augmented trabeculotomy-trabeculectomy for primary congenital glaucoma .", "sentence_id": 0}
+{"abstract_id": "25486542", "label": "methods", "text": "Prospective , randomized trial .", "sentence_id": 1}
+{"abstract_id": "25486542", "label": "methods", "text": "Of the @ patients ( @ eyes ) analyzed with bilateral primary congenital glaucoma aged @ years , @ eye of each patient was randomized to : illuminated microcatheter-assisted trabeculotomy ( Group I ) or combined trabeculotomy with trabeculectomy augmented with mitomycin C ( Group II ) .", "sentence_id": 2}
+{"abstract_id": "25486542", "label": "methods", "text": "Primary outcome measure was intraocular pressure ( IOP ) reduction .", "sentence_id": 3}
+{"abstract_id": "25486542", "label": "methods", "text": "Categorization into absolute success ( IOP @mm Hg without medication ) and qualified success ( IOP @mm Hg with medication ) was done .", "sentence_id": 4}
+{"abstract_id": "25486542", "label": "methods", "text": "Secondary outcomes included change in corneal diameter and clarity , optic disc status , refraction , need for anti-glaucoma therapy , and occurrence of complications .", "sentence_id": 5}
+{"abstract_id": "25486542", "label": "results", "text": "Mean age of patients was @ @ months .", "sentence_id": 6}
+{"abstract_id": "25486542", "label": "results", "text": "IOP fell by @ % ( @ @ to @ @ mm Hg ) in Group I and @ % in Group II ( @ @ to @ @ mm Hg ) ( P < @ in both ) .", "sentence_id": 7}
+{"abstract_id": "25486542", "label": "results", "text": "At @ year , absolute success was achieved in @ % ( @/@ ) and @ % ( @/@ ) in Groups I and II , respectively ( P > @ ) and qualified success in @ % ( @/@ ) in both groups ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25486542", "label": "results", "text": "There was significant improvement in corneal clarity ( P < @ ) and cup-to-disc ratio ( P @ ) in both groups at @ year .", "sentence_id": 9}
+{"abstract_id": "25486542", "label": "results", "text": "Though incidence of hyphema was significantly more in Group I ( P = @ ) , no vision-threatening complications occurred in either group .", "sentence_id": 10}
+{"abstract_id": "25486542", "label": "conclusions", "text": "Illuminated microcatheter-assisted circumferential trabeculotomy achieved comparable surgical outcomes to mitomycin C-augmented combined trabeculotomy-trabeculectomy and may be recommended as the initial surgical procedure for primary congenital glaucoma .", "sentence_id": 11}
+{"abstract_id": "25403717", "label": "background", "text": "Non-attenders for cervical screening are at increased risk of cervical cancer .", "sentence_id": 0}
+{"abstract_id": "25403717", "label": "background", "text": "Studies offering self-sampling for high-risk Human Papillomavirus ( HrHPV ) testing have shown greater uptake than sending another invitation for cytology .", "sentence_id": 1}
+{"abstract_id": "25403717", "label": "objective", "text": "To explore whether uptake would increase in a less diverse , more stable population than the previous English study , which demonstrated a lower response rate than other studies .", "sentence_id": 2}
+{"abstract_id": "25403717", "label": "objective", "text": "The primary objective was whether non-attenders were more likely to respond to a postal invitation , including kit , to collect a self-sample compared with a further invitation for cytology screening .", "sentence_id": 3}
+{"abstract_id": "25403717", "label": "objective", "text": "The secondary objective was whether women with an abnormal result would attend for follow-up .", "sentence_id": 4}
+{"abstract_id": "25403717", "label": "methods", "text": "@ non-attenders for screening in this pragmatic , randomized ( @:@ ) controlled trial in Newcastle-upon-Tyne were sent an HPV self-sample kit ( intervention ) or a further invitation for cytology screening ( comparator ) .", "sentence_id": 5}
+{"abstract_id": "25403717", "label": "results", "text": "@ ( @ % ) responded to the intervention , returning a self-sample ( @ ( @ % ) ) or attending for cytology ( @ ( @ % ) ) , compared with @ ( @ % ) attending for cytology , relative risk @ ( @ % CI @-@ @ ) ( comparator arm ) .", "sentence_id": 6}
+{"abstract_id": "25403717", "label": "results", "text": "Of those testing hrHPV positive ( @ ( @ % ) ) , @ ( @ % ) subsequently attended cytology screening .", "sentence_id": 7}
+{"abstract_id": "25403717", "label": "results", "text": "Of those in the intervention group who attended for cytology screening without returning an hrHPV self-sample ( n = @ ) , @ % ( n = @ ) were referred for colposcopy-all attended .", "sentence_id": 8}
+{"abstract_id": "25403717", "label": "results", "text": "In the comparator group eight of the nine referred for colposcopy attended .", "sentence_id": 9}
+{"abstract_id": "25403717", "label": "conclusions", "text": "Persistent non-responders to invitations for cervical screening are significantly more likely to respond to a postal invitation to return a self-collected sample for HPV testing than a further invitation for cytology screening .", "sentence_id": 10}
+{"abstract_id": "25403717", "label": "conclusions", "text": "However , just over half followed up on this positive HPV result .", "sentence_id": 11}
+{"abstract_id": "24418670", "label": "objective", "text": "To examine how the location where reading takes place and the availability of prior images can affect performance in breast test-set reading .", "sentence_id": 0}
+{"abstract_id": "24418670", "label": "methods", "text": "Under optimized viewing conditions , @ expert screen readers each interpreted a reader-specific set of images containing @ mammographic cases .", "sentence_id": 1}
+{"abstract_id": "24418670", "label": "methods", "text": "Readers , randomly divided into two groups read images under one of two pairs of conditions : clinical read with prior images and laboratory read with prior images ; laboratory read with prior images and laboratory read without prior images .", "sentence_id": 2}
+{"abstract_id": "24418670", "label": "methods", "text": "Region-of-interest ( ROI ) figure-of-merit ( FOM ) was analysed using JAFROC software .", "sentence_id": 3}
+{"abstract_id": "24418670", "label": "methods", "text": "Breast side-specific sensitivity and specificity were tested using Wilcoxon matched-pairs signed rank tests .", "sentence_id": 4}
+{"abstract_id": "24418670", "label": "methods", "text": "Agreement between pairs of readings was measured using Kendall 's coefficient of concordance .", "sentence_id": 5}
+{"abstract_id": "24418670", "label": "results", "text": "Group performances between test-set readings demonstrated similar ROI FOMs , sensitivity and specificity median values , and acceptable levels of agreement between pairs of readings were shown ( W = @-@ @ , p < @ ) for both pairs of reading conditions .", "sentence_id": 6}
+{"abstract_id": "24418670", "label": "results", "text": "On an individual reader level , two readers demonstrated significant decreases ( p < @ ) in ROI FOMs when prior images were unavailable .", "sentence_id": 7}
+{"abstract_id": "24418670", "label": "results", "text": "Reading location had an inconsistent impact on individual performance .", "sentence_id": 8}
+{"abstract_id": "24418670", "label": "conclusions", "text": "Reading location and availability of prior images did not significantly alter group performance .", "sentence_id": 9}
+{"abstract_id": "25575599", "label": "background", "text": "Effective strategies for contacting and recruiting study participants are critical in conducting clinical research .", "sentence_id": 0}
+{"abstract_id": "25575599", "label": "background", "text": "In this study , we conducted two sequential randomized controlled trials of mail - and telephone-based strategies for contacting and recruiting participants , and evaluated participant-related variables ' association with time to survey completion and survey completion rates .", "sentence_id": 1}
+{"abstract_id": "25575599", "label": "background", "text": "Subjects eligible for this study were survivors of acute lung injury who had been previously enrolled in a @-month observational follow-up study evaluating their physical , cognitive and mental health outcomes , with their last study visit completed at a median of @ months previously .", "sentence_id": 2}
+{"abstract_id": "25575599", "label": "methods", "text": "Eligible subjects were contacted to complete a new research survey as part of two randomized trials , initially using a randomized mail-based contact strategy , followed by a randomized telephone-based contact strategy for non-responders to the mail strategy .", "sentence_id": 3}
+{"abstract_id": "25575599", "label": "methods", "text": "Both strategies focused on using either a personalized versus a generic approach .", "sentence_id": 4}
+{"abstract_id": "25575599", "label": "methods", "text": "In addition , @ potentially relevant subject-related variables ( e.g. , demographics , last known physical and mental health status ) were evaluated for association with time to survey completion .", "sentence_id": 5}
+{"abstract_id": "25575599", "label": "results", "text": "Of @ eligible subjects , @ % completed the survey with a median ( IQR ) of @ ( @ , @ ) contact attempts required .", "sentence_id": 6}
+{"abstract_id": "25575599", "label": "results", "text": "There was no significant difference in the time to survey completion for either randomized trial of mail - or phone-based contact strategy .", "sentence_id": 7}
+{"abstract_id": "25575599", "label": "results", "text": "Among all subject-related variables , age @ years and minority race were independently associated with a longer time to survey completion .", "sentence_id": 8}
+{"abstract_id": "25575599", "label": "conclusions", "text": "We found that age @ years and minority race were associated with a longer time to survey completion , but personalized versus generic approaches to mail - and telephone-based contact strategies had no significant effect .", "sentence_id": 9}
+{"abstract_id": "25575599", "label": "conclusions", "text": "Repeating both mail and telephone contact attempts was important for increasing survey completion rate .", "sentence_id": 10}
+{"abstract_id": "24717710", "label": "objective", "text": "The purpose of this study was to compare the pain rating scale measurements from an exposure group ( injections with the aid of DentalVibe Injection Comfort System ) and control group ( traditional injection without the aid of the DentalVibe ) in adolescent patients using self-reported pain during administration of local anesthetic injections .", "sentence_id": 0}
+{"abstract_id": "24717710", "label": "methods", "text": "This was a randomized , controlled study .", "sentence_id": 1}
+{"abstract_id": "24717710", "label": "methods", "text": "Subjects consisted of @ @ - to @-year-old patients who required local anesthesia for dental treatment on both sides of the maxilla or mandible .", "sentence_id": 2}
+{"abstract_id": "24717710", "label": "methods", "text": "All subjects received a conventional injection ( control ) and an injection using DentalVibe ( experimental ) .", "sentence_id": 3}
+{"abstract_id": "24717710", "label": "methods", "text": "A pain rating for each injection was obtained from subjects using the Wong-Baker FACES Pain Rating Scale .", "sentence_id": 4}
+{"abstract_id": "24717710", "label": "results", "text": "Statistical analysis using a Wilcoxon signed rank test found a significant reduction in pain ratings for injections with the DentalVibe when compared to control injections .", "sentence_id": 5}
+{"abstract_id": "24717710", "label": "results", "text": "There was a positive correlation between the pain rating for control injection and the difference between the two types of injection , indicating that subjects who reported a higher pain score with the control injection had a greater reduction when DentalVibe was used .", "sentence_id": 6}
+{"abstract_id": "24717710", "label": "conclusions", "text": "When compared to a conventional approach , DentalVibe significantly lowered self-reported pain during local anesthesia injection for adolescent subjects in this study .", "sentence_id": 7}
+{"abstract_id": "25741642", "label": "background", "text": "Recent recommendations for lung protective mechanical ventilation include a tidal volume target of @ mL/kg predicted body weight ( PBW ) .", "sentence_id": 0}
+{"abstract_id": "25741642", "label": "background", "text": "Different PBW equations might introduce important differences in tidal volumes delivered to research subjects and patients .", "sentence_id": 1}
+{"abstract_id": "25741642", "label": "methods", "text": "PBW equations use height , age , and sex as input variables .", "sentence_id": 2}
+{"abstract_id": "25741642", "label": "methods", "text": "We compared National Institutes of Health ( NIH ) ARDS Network ( ARDSNet ) , actuarial table ( ACTUARIAL ) , and Stewart ( STEWART ) PBW equations used in clinical trials , across physiologic ranges for age and height .", "sentence_id": 3}
+{"abstract_id": "25741642", "label": "methods", "text": "We used three-dimensional and two-dimensional surface analysis to compare these PBW equations .", "sentence_id": 4}
+{"abstract_id": "25741642", "label": "methods", "text": "We then used age and height from actual clinical trial subjects to quantify PBW equation differences .", "sentence_id": 5}
+{"abstract_id": "25741642", "label": "results", "text": "Significant potential differences existed between these PBW predictions .", "sentence_id": 6}
+{"abstract_id": "25741642", "label": "results", "text": "The ACTUARIAL and ARDSNet surfaces for women were the only surfaces that intersected and produced both positive and negative differences .", "sentence_id": 7}
+{"abstract_id": "25741642", "label": "results", "text": "Mathematical differences between PBW equations at limits of height and age exceeded @ % in women and @ % in men for ACTUARIAL vs ARDSNet and about @ % for women and @ % for men for STEWART vs ARDSNet .", "sentence_id": 8}
+{"abstract_id": "25741642", "label": "results", "text": "The largest mathematical differences were present in older , shorter subjects , especially women .", "sentence_id": 9}
+{"abstract_id": "25741642", "label": "results", "text": "Actual differences for clinical trial subjects were as high as @ % for men and @ % for women .", "sentence_id": 10}
+{"abstract_id": "25741642", "label": "conclusions", "text": "Significant differences between PBW equations for both men and women could be important sources of interstudy variation .", "sentence_id": 11}
+{"abstract_id": "25741642", "label": "conclusions", "text": "Studies should adopt a standard PBW equation .", "sentence_id": 12}
+{"abstract_id": "25741642", "label": "conclusions", "text": "We recommend using the NIH National Heart , Lung , and Blood Institute ARDS Network PBW equation because it is associated with the clinical trial that identified @ mL/kg PBW as an appropriate target .", "sentence_id": 13}
+{"abstract_id": "26035724", "label": "objective", "text": "The authors examined the impacts of whole-body vibration ( WBV ) applications on balance control in postmenopausal women using clinical balance tests and computerized static posturography .", "sentence_id": 0}
+{"abstract_id": "26035724", "label": "methods", "text": "Patients were randomly divided into two groups and treated with WBV and/or home-based balance coordination exercises ( BCEs ) .", "sentence_id": 1}
+{"abstract_id": "26035724", "label": "methods", "text": "Patients in the WBV-BCE group were asked to stand on the platform in standing , squat , and deep squat positions .", "sentence_id": 2}
+{"abstract_id": "26035724", "label": "methods", "text": "During each position , @-sec vibration ( @-@ Hz ) and @-sec rest periods were applied twice ( @ sessions in total ) .", "sentence_id": 3}
+{"abstract_id": "26035724", "label": "methods", "text": "The BCE program was performed by subjects twice per day .", "sentence_id": 4}
+{"abstract_id": "26035724", "label": "methods", "text": "All subjects were evaluated before and after treatment using the Timed Up and Go test and the Berg Balance Scale ( BBS ) .", "sentence_id": 5}
+{"abstract_id": "26035724", "label": "methods", "text": "The fall index and the Fourier index were assessed via computerized static posturography .", "sentence_id": 6}
+{"abstract_id": "26035724", "label": "results", "text": "Sixty patients were recruited for the study , but only @ patients ( @ in each group ) completed it .", "sentence_id": 7}
+{"abstract_id": "26035724", "label": "results", "text": "Fall index and the total values of the Fourier index @-@ and Fourier index @-@ frequencies indicated a significant improvement in the WBV-BCE group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "26035724", "label": "results", "text": "Both groups showed significant improvements in the Berg Balance Scale and Timed Up and Go test ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "26035724", "label": "conclusions", "text": "The ease of applying WBV furthermore supports its inclusion in daily treatment protocols for age-related decline in balance performance in women and improved balance and mobility measures associated with increased fall risk .", "sentence_id": 10}
+{"abstract_id": "25100891", "label": "background", "text": "There is controversy in medical literature regarding the use of electromagnetic fields to promote bone healing .", "sentence_id": 0}
+{"abstract_id": "25100891", "label": "methods", "text": "After designing and building devices capable of generating an electromagnetic field for this study , their safety was confirmed and the electromagnetic therapy was randomly allocated and compared to placebo in patients with fracture of the femoral diaphysis .", "sentence_id": 1}
+{"abstract_id": "25100891", "label": "methods", "text": "Treatment began six weeks after the fracture and it was administered once a day , during @ h , for eight consecutive weeks .", "sentence_id": 2}
+{"abstract_id": "25100891", "label": "methods", "text": "Twenty device were built , @ of which were placebo-devices .", "sentence_id": 3}
+{"abstract_id": "25100891", "label": "methods", "text": "Between June @ and October @ , @ patients were randomized in two different hospitals and were followed for @ weeks .", "sentence_id": 4}
+{"abstract_id": "25100891", "label": "methods", "text": "The mean age was @ years ( @-@ ) and @ % were males .", "sentence_id": 5}
+{"abstract_id": "25100891", "label": "results", "text": "Healing observed at week @ was @ % vs. @ % ( p = @ ) ; at week @ it was @ % vs. @ % ( p = @ ) ; and at week @ it was @ % vs. @ % ( p = @ ) for the device group and the placebo group , respectively .", "sentence_id": 6}
+{"abstract_id": "25100891", "label": "conclusions", "text": "This study suggests that an electromagnetic field stimulus can promote earlier bone healing compared to placebo in femoral diaphyseal fractures .", "sentence_id": 7}
+{"abstract_id": "25100891", "label": "conclusions", "text": "Faster bone healing translates into sooner weight bearing , which -- in turn -- permits quicker return to normal daily activities .", "sentence_id": 8}
+{"abstract_id": "25046167", "label": "objective", "text": "The aim of this study was to assess in healthy subjects the safety , tolerability , pharmacokinetics , and pharmacodynamics of ponesimod , an oral selective sphingosine-@-phosphate receptor @ ( S@P@ ) modulator in development for multiple sclerosis , by using an uptitration scheme up to supratherapeutic doses .", "sentence_id": 0}
+{"abstract_id": "25046167", "label": "methods", "text": "This was a double-blind , placebo-controlled , randomised , parallel group , uptitration study .", "sentence_id": 1}
+{"abstract_id": "25046167", "label": "methods", "text": "Male and female subjects received ascending oral doses of ponesimod ( n = @ ) or placebo ( n = @ ) once daily for @ days at each dose level ( @-@-@-@-@-@mg ) .", "sentence_id": 2}
+{"abstract_id": "25046167", "label": "results", "text": "The most frequent adverse events were chest discomfort , headache , dizziness , dyspnoea , abdominal pain , and night sweats .", "sentence_id": 3}
+{"abstract_id": "25046167", "label": "results", "text": "Chest discomfort and dyspnoea were considered dose-limiting .", "sentence_id": 4}
+{"abstract_id": "25046167", "label": "results", "text": "A transient decrease in heart rate was observed following the first @-mg ponesimod dose ( maximum mean decrease of @ beats per minute ( bpm ) ( placebo : @ bpm ) ) .", "sentence_id": 5}
+{"abstract_id": "25046167", "label": "results", "text": "After uptitration , effects on heart rate were indistinguishable from placebo .", "sentence_id": 6}
+{"abstract_id": "25046167", "label": "results", "text": "A dose-dependent effect on pulmonary function tests was observed and reached a plateau with @-@ mg ponesimod ( maximum mean decrease from baseline of @ l ( -@ % ) in forced expiratory volume in @s ) .", "sentence_id": 7}
+{"abstract_id": "25046167", "label": "results", "text": "A plateau in mean lymphocyte count reduction of approximately @ % from baseline was reached at the @ mg dose level .", "sentence_id": 8}
+{"abstract_id": "25046167", "label": "results", "text": "Observed effects were fully reversible within @days after treatment discontinuation .", "sentence_id": 9}
+{"abstract_id": "25046167", "label": "results", "text": "No relevant sex differences were observed .", "sentence_id": 10}
+{"abstract_id": "25046167", "label": "conclusions", "text": "At supratherapeutic doses , symptoms of chest discomfort and dyspnoea were dose-limiting .", "sentence_id": 11}
+{"abstract_id": "25046167", "label": "conclusions", "text": "An uptitration dosing scheme is to be preferred in clinical studies in patients in order to limit effects of ponesimod on heart rate and atrioventricular ( AV ) conduction .", "sentence_id": 12}
+{"abstract_id": "24812022", "label": "background", "text": "A recent meta-analysis of Internet interventions for smoking cessation found mixed evidence regarding effectiveness .", "sentence_id": 0}
+{"abstract_id": "24812022", "label": "background", "text": "One explanation may be differential use of non-assigned cessation treatments-including other Internet programs-that either amplify or mask study intervention effects .", "sentence_id": 1}
+{"abstract_id": "24812022", "label": "background", "text": "We examined the impact of non-assigned treatment use on cessation outcomes in The iQUITT Study , a randomized trial of Internet and telephone treatment for smoking cessation .", "sentence_id": 2}
+{"abstract_id": "24812022", "label": "methods", "text": "Participants were randomized to a basic Internet ( BI ) comparison condition ( N = @ ) , enhanced Internet ( EI : N = @ ) , or EI plus telephone counseling ( EI+P : N = @ ) .", "sentence_id": 3}
+{"abstract_id": "24812022", "label": "methods", "text": "The primary outcome was @-day point prevalence abstinence ( ppa ) at @ and @ months .", "sentence_id": 4}
+{"abstract_id": "24812022", "label": "methods", "text": "Assigned intervention use was assessed with automated tracking data .", "sentence_id": 5}
+{"abstract_id": "24812022", "label": "methods", "text": "Assessment of non-assigned treatments included pharmacotherapy , behavioral , alternative , and non-study Internet treatments .", "sentence_id": 6}
+{"abstract_id": "24812022", "label": "methods", "text": "Univariate and multivariate logistic regression models examined whether non-assigned treatment use was associated with @-day ppa .", "sentence_id": 7}
+{"abstract_id": "24812022", "label": "results", "text": "About @ % of participants used at least one non-assigned treatment .", "sentence_id": 8}
+{"abstract_id": "24812022", "label": "results", "text": "A higher rate of non-study Internet treatment among BI participants was the only treatment group difference at both @ and @ months .", "sentence_id": 9}
+{"abstract_id": "24812022", "label": "results", "text": "Multivariate models controlling for condition and baseline predictors of non-assigned treatment use showed that high-intensity non-study Internet treatment was positively associated with @-day ppa at @ and @ months , and pharmacotherapy and behavioral treatment use was negatively associated with @-day ppa at @ months .", "sentence_id": 10}
+{"abstract_id": "24812022", "label": "conclusions", "text": "Non-assigned treatment use is an important factor to consider when evaluating Internet cessation interventions .", "sentence_id": 11}
+{"abstract_id": "24812022", "label": "conclusions", "text": "Results highlight methodological issues in selecting a comparison condition .", "sentence_id": 12}
+{"abstract_id": "24812022", "label": "conclusions", "text": "Researchers should report non-assigned treatment use alongside main trial outcomes .", "sentence_id": 13}
+{"abstract_id": "24423909", "label": "objective", "text": "To explore the effects of nutritional liquid supplement designed for diabetes mellitus on postprandial glucose state and pregnancy outcomes in patients with gestational diabetes mellitus ( GDM ) .", "sentence_id": 0}
+{"abstract_id": "24423909", "label": "methods", "text": "A total of @ cases of pregnant GDM women at Department of Obstetrics & Gynecology , First Affiliated Hospital , Chongqing Medical University from October @ to January @ were randomized into the intervention and control groups .", "sentence_id": 1}
+{"abstract_id": "24423909", "label": "methods", "text": "But only @ cases in intervention group finished the study versus @ cases in control group .", "sentence_id": 2}
+{"abstract_id": "24423909", "label": "methods", "text": "The inter-group differences were analyzed for general clinical profiles before intervention , @-hour postprandial blood glucose levels and pregnancy outcomes , etc. .", "sentence_id": 3}
+{"abstract_id": "24423909", "label": "methods", "text": "The General Linear Model Repeated Measures process was used to analyze the variance of @-hour postprandial blood glucose data .", "sentence_id": 4}
+{"abstract_id": "24423909", "label": "methods", "text": "And the Mauchy 's test of sphericity was employed to determine the correlation .", "sentence_id": 5}
+{"abstract_id": "24423909", "label": "results", "text": "( @ ) No significant difference in general clinical profiles before intervention between intervention and control groups ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24423909", "label": "results", "text": "( @ ) The mean values of @-hour postprandial blood glucose were as follows : intervention group ( mmol/L ) : @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) ; control group : @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) , @ @ ( @w ) .", "sentence_id": 7}
+{"abstract_id": "24423909", "label": "results", "text": "The results of Mauchy 's test of sphericity indicated that the blood glucose level of the intervention group was significantly lower than that of the control group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24423909", "label": "results", "text": "( @ ) The incidence of premature rupture of membranes and polyhydramnios , rate of neonatal pneumonia , weight of newborn and pregnancy women and level of glycosylated hemoglobin in intervention group were significantly lower than those in control group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24423909", "label": "conclusions", "text": "Compared with common diet , after using nutritional supplement , the postprandial blood glucose level is significantly reduced and the pregnancy outcomes also improved in GDM patients .", "sentence_id": 10}
+{"abstract_id": "25753869", "label": "objective", "text": "This prospective randomized study evaluated the efficacy of a @ mm locking plate/screw system compared with a @-mm nonlocking plate/screw system in fixation of @ isolated non-comminuted mandibular angle fractures .", "sentence_id": 0}
+{"abstract_id": "25753869", "label": "methods", "text": "Sixty patients were randomly assigned to receive a @ mm locking plate ( group A , n = @ ) or @ mm non-locking plate ( group B , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25753869", "label": "methods", "text": "All patients were followed up to @ months postoperatively and evaluated for complications , occlusal stability and overall results of fixation .", "sentence_id": 2}
+{"abstract_id": "25753869", "label": "results", "text": "Five complications occurred in the locking group and fourteen in the non-locking group with complication rates equalling @ % and @ % respectively .", "sentence_id": 3}
+{"abstract_id": "25753869", "label": "results", "text": "When comparing the overall results according to plates used , the test showed a statistically significant difference between the locking and non-locking plates ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25753869", "label": "results", "text": "Fewer patients required IMF in group A.", "sentence_id": 5}
+{"abstract_id": "25753869", "label": "conclusions", "text": "Mandibular angle fractures treated with @ mm locking plates show greater stability and were associated with fewer complications than with @ mm non-locking plates .", "sentence_id": 6}
+{"abstract_id": "25455875", "label": "objective", "text": "To conduct a follow-up association mapping to independent genome-wide linkage and admixture mapping studies of uterine leiomyoma .", "sentence_id": 0}
+{"abstract_id": "25455875", "label": "methods", "text": "Case-control , cross-sectional study .", "sentence_id": 1}
+{"abstract_id": "25455875", "label": "methods", "text": "Not applicable .", "sentence_id": 2}
+{"abstract_id": "25455875", "label": "methods", "text": "A total of @,@ premenopausal North American participants in the National Institute of Environmental Health Sciences Uterine Fibroid Study .", "sentence_id": 3}
+{"abstract_id": "25455875", "label": "methods", "text": "None .", "sentence_id": 4}
+{"abstract_id": "25455875", "label": "methods", "text": "We genotyped @,@ single-nucleotide polymorphisms from candidate genes located in peaks of linkage ( @q@ , @p@ , @p@ , @p@ , @p@ , @q@ , and @q@ ) or admixture linkage disequilibrium ( @q@ , @p@ @ , and @q@ ) mapping and reported to have regulated expression in uterine fibroids .", "sentence_id": 5}
+{"abstract_id": "25455875", "label": "results", "text": "We report significant associations of variant members of the collagen gene family with risk and tumor size , including missense variants in COL@A@ and COL@A , with replications in African American and European American study groups .", "sentence_id": 6}
+{"abstract_id": "25455875", "label": "results", "text": "Furthermore , the cell-matrix Rho GTPase-encoding ARHGAP@ gene , and MAN@C@ , a gene encoding a Golgi mannosidase involved in the maturation of procollagens , emerged as new candidate uterine leiomyoma genes affecting both risk and tumor size .", "sentence_id": 7}
+{"abstract_id": "25455875", "label": "conclusions", "text": "Our data converge onto a possible model of uterine leiomyoma pathogenesis resulting from altered regulation , maintenance , and/or renewal of the extracellular matrix .", "sentence_id": 8}
+{"abstract_id": "25616607", "label": "objective", "text": "Ureaplasma urealyticum biovar @ ( UU-@ ) , but not Ureaplasma parvum ( UP ) , has been associated with non-gonococcal urethritis ( NGU ) , but little is known about species-specific responses to standard therapies .", "sentence_id": 0}
+{"abstract_id": "25616607", "label": "objective", "text": "We examined species-specific treatment outcomes and followed men with treatment failure for @weeks .", "sentence_id": 1}
+{"abstract_id": "25616607", "label": "methods", "text": "From May @ to July @ , men aged @ attending a sexually transmitted disease ( STD ) clinic in Seattle , Washington , with NGU ( urethral discharge or urethral symptoms plus @ polymorphonuclear leucocytes / high-powered field ) enrolled in a double-blind , randomised trial .", "sentence_id": 2}
+{"abstract_id": "25616607", "label": "methods", "text": "Participants received active azithromycin ( @g ) + placebo doxycycline or active doxycycline ( @mg twice a day @days ) + placebo azithromycin .", "sentence_id": 3}
+{"abstract_id": "25616607", "label": "methods", "text": "Ureaplasma were detected in culture followed by species-specific PCR .", "sentence_id": 4}
+{"abstract_id": "25616607", "label": "methods", "text": "Outcomes were assessed at @ , @ and @weeks .", "sentence_id": 5}
+{"abstract_id": "25616607", "label": "methods", "text": "At @weeks , men with persistent Ureaplasma detection received ` reverse therapy ' ( e.g. , active doxycycline if they first received active azithromycin ) .", "sentence_id": 6}
+{"abstract_id": "25616607", "label": "methods", "text": "At @weeks , persistently positive men received moxifloxacin ( @mg@days ) .", "sentence_id": 7}
+{"abstract_id": "25616607", "label": "results", "text": "Of @ men , @ ( @ % ) and @ ( @ % ) were infected with UU-@ and UP , respectively , and returned at @weeks .", "sentence_id": 8}
+{"abstract_id": "25616607", "label": "results", "text": "Persistent detection was similar for UU-@-infected men initially treated with azithromycin or doxycycline ( @ % vs. @ % ; p = @ ) , but differed somewhat for men with UP ( @ % vs. @ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25616607", "label": "results", "text": "At @weeks , @ % of UU-@-infected and @ % of UP-infected men who received both drugs had persistent detection .", "sentence_id": 10}
+{"abstract_id": "25616607", "label": "results", "text": "Failure after moxifloxacin occurred in @ % and @ % , respectively .", "sentence_id": 11}
+{"abstract_id": "25616607", "label": "results", "text": "Persistent detection of UU-@ or UP was not associated with signs/symptoms of NGU .", "sentence_id": 12}
+{"abstract_id": "25616607", "label": "conclusions", "text": "Persistent detection after treatment with doxycycline , azithromycin and moxifloxacin was common for UU and UP , but not associated with persistent urethritis .", "sentence_id": 13}
+{"abstract_id": "24268433", "label": "objective", "text": "To explore effects of whole-head/body tilt in the roll plane on ocular-vestibular evoked myogenic potentials ( oVEMP ) .", "sentence_id": 0}
+{"abstract_id": "24268433", "label": "methods", "text": "Twenty healthy subjects were randomly tilted in an Eply Omniax rotator across a series of eight angles from @ to @ ( at @ separations ) in the roll plane .", "sentence_id": 1}
+{"abstract_id": "24268433", "label": "methods", "text": "At each position , oVEMPs to air-conducted ( AC ) and bone-conducted ( BC ) stimulation were recorded from unrectified infra-orbital surface electromyography during upward gaze .", "sentence_id": 2}
+{"abstract_id": "24268433", "label": "methods", "text": "oVEMP amplitudes , latencies and amplitude asymmetry were compared across each angle of orientation .", "sentence_id": 3}
+{"abstract_id": "24268433", "label": "results", "text": "Head orientation had a significant effect on oVEMP reflex amplitudes for both AC and BC stimulation ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24268433", "label": "results", "text": "For both stimuli there was a trend for lower amplitudes with increasing angular departure from the upright position .", "sentence_id": 5}
+{"abstract_id": "24268433", "label": "results", "text": "Mean amplitudes decreased by @-@ @ % ( AC ) and @-@ @ % ( BC ) when tilted @ .", "sentence_id": 6}
+{"abstract_id": "24268433", "label": "results", "text": "Roll-plane tilt had a significant effect on amplitude asymmetry ratios recorded in response to AC stimuli ( p < @ ) , indicating a trend for lower amplitudes from the dependent ( down ) ear .", "sentence_id": 7}
+{"abstract_id": "24268433", "label": "results", "text": "Amplitude asymmetry ratios for BC stimuli were unaffected by head and body orientation .", "sentence_id": 8}
+{"abstract_id": "24268433", "label": "conclusions", "text": "The results confirm an effect of head and body orientation on oVEMP reflexes recorded in response to air - and bone-conducted stimuli .", "sentence_id": 9}
+{"abstract_id": "24268433", "label": "conclusions", "text": "The upright position yields an optimal oVEMP response .", "sentence_id": 10}
+{"abstract_id": "25748566", "label": "objective", "text": "To evaluate the efficacy and safety of nebulized pentoxifylline for reducing the duration of oxygen supplementation in extremely preterm neonates at high risk of bronchopulmonary dysplasia ( BPD ) .", "sentence_id": 0}
+{"abstract_id": "25748566", "label": "methods", "text": "Single-center , randomized , double-blind , placebo-controlled trial was conducted .", "sentence_id": 1}
+{"abstract_id": "25748566", "label": "methods", "text": "Infants of @ ( @ ) to @ ( @ ) weeks ' gestational age requiring mechanical ventilation or @ % supplemental oxygen on continuous positive airway pressure at @-@ hours were randomized to receive @ mg/kg ( @ mL/kg ) nebulized pentoxifylline or an equal volume of normal saline placebo every @ hours for @ consecutive days via a vibrating mesh nebulizer .", "sentence_id": 2}
+{"abstract_id": "25748566", "label": "methods", "text": "The primary outcome was the duration of oxygen supplementation at @ weeks ' postmenstrual age .", "sentence_id": 3}
+{"abstract_id": "25748566", "label": "methods", "text": "We used Cox proportional hazards regression modeling to analyze outcomes .", "sentence_id": 4}
+{"abstract_id": "25748566", "label": "results", "text": "All infants had adequate data for analysis of the primary outcome .", "sentence_id": 5}
+{"abstract_id": "25748566", "label": "results", "text": "Intention-to-treat analysis revealed no differences in duration of oxygen supplementation at @ weeks ' postmenstrual age between pentoxifylline ( n = @ ) and placebo ( n = @ ) groups ( median @ vs @ hours , adjusted hazard ratio : @ , @ % CI @-@ @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25748566", "label": "results", "text": "There was no difference in mortality and further secondary outcomes .", "sentence_id": 7}
+{"abstract_id": "25748566", "label": "results", "text": "No adverse effects were noted .", "sentence_id": 8}
+{"abstract_id": "25748566", "label": "conclusions", "text": "Nebulized pentoxifylline is safe but did not reduce the duration of oxygen supplementation in extremely preterm infants at high risk of BPD .", "sentence_id": 9}
+{"abstract_id": "25748566", "label": "conclusions", "text": "Dose-ranging studies and large , well-designed clinical trials are required to determine whether the use of nebulized or systemic pentoxifylline as a prophylactic therapy offers small but relevant benefits for prevention of BPD .", "sentence_id": 10}
+{"abstract_id": "24821270", "label": "background", "text": "Secondhand smoke exposure ( SHSe ) is a significant modifiable risk for respiratory health in children .", "sentence_id": 0}
+{"abstract_id": "24821270", "label": "background", "text": "Although SHSe is declining overall , it has increased for low-income and minority populations .", "sentence_id": 1}
+{"abstract_id": "24821270", "label": "background", "text": "Implementation of effective SHSe interventions within community organizations has the potential for significant public health impact .", "sentence_id": 2}
+{"abstract_id": "24821270", "label": "objective", "text": "To evaluate the effectiveness of motivational interviewing ( MI ) delivered in the context of a SHS education reduction initiative within Head Start to reduce preschool children 's SHSe .", "sentence_id": 3}
+{"abstract_id": "24821270", "label": "methods", "text": "A total of @ children enrolled in Baltimore City Head Start whose caregivers reported a smoker living in the home were recruited .", "sentence_id": 4}
+{"abstract_id": "24821270", "label": "methods", "text": "Caregivers were randomized to MI + education or education alone .", "sentence_id": 5}
+{"abstract_id": "24821270", "label": "methods", "text": "Assessments were conducted at baseline , @ , @ , and @ months .", "sentence_id": 6}
+{"abstract_id": "24821270", "label": "results", "text": "The primary outcome measure was household air nicotine levels measured by passive dosimeters .", "sentence_id": 7}
+{"abstract_id": "24821270", "label": "results", "text": "Secondary outcomes included child salivary cotinine , self-report of home smoking ban ( HSB ) , and smoking status .", "sentence_id": 8}
+{"abstract_id": "24821270", "label": "results", "text": "Participants in the MI + education group had significantly lower air nicotine levels ( @ vs. @ mg ) , @ % increase in prevalence of caregiver-reported HSBs , and a @ % decrease in caregiver smokers compared with education-alone group ( all P values < @ ) .", "sentence_id": 9}
+{"abstract_id": "24821270", "label": "results", "text": "Although group differences in salivary cotinine were not significant , among all families who reported having an HSB , salivary cotinine and air nicotine levels declined in both groups ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24821270", "label": "conclusions", "text": "MI may be effective in community settings to reduce child SHSe .", "sentence_id": 11}
+{"abstract_id": "24821270", "label": "conclusions", "text": "More research is needed to identify ways to tailor interventions to directly impact child SHSe and to engage more families to make behavioral change .", "sentence_id": 12}
+{"abstract_id": "24821270", "label": "conclusions", "text": "Clinical trial registered with www.clinicaltrials.gov ( NCT @ ) .", "sentence_id": 13}
+{"abstract_id": "24460292", "label": "background", "text": "Conspicuous differences in participation rates for breast self-examination ( BSE ) , clinical breast examination ( CBE ) , and referral for further investigations have been observed indicating involvement of a number of different factors .", "sentence_id": 0}
+{"abstract_id": "24460292", "label": "background", "text": "This study analysed determinants for participation in different levels of the breast cancer screening process in Indian females .", "sentence_id": 1}
+{"abstract_id": "24460292", "label": "methods", "text": "An intervention group of @,@ women was interviewed in a breast cancer screening trial in Trivandrum district , India .", "sentence_id": 2}
+{"abstract_id": "24460292", "label": "methods", "text": "In order to assess demographic , socio-economic , reproductive , and cancer-related determinants of participation in BSE , CBE , and referral , uni - and multi-variate logistic regression was employed .", "sentence_id": 3}
+{"abstract_id": "24460292", "label": "results", "text": "Of the interviewed women , @ % reported practicing BSE , @ % had attended CBE , and @ % of @,@ screen-positives attended referral .", "sentence_id": 4}
+{"abstract_id": "24460292", "label": "results", "text": "Results showed an influence of various determinants on participation ; women who were currently not married or who had no family history of cancer were significantly less likely to attend the screening process at any level .", "sentence_id": 5}
+{"abstract_id": "24460292", "label": "conclusions", "text": "Increasing awareness about breast cancer , early detection methods , and the advantages of early diagnoses among women , and their families , as well as health care workers offering social support , could help to increase participation over the entire screening process in India .", "sentence_id": 6}
+{"abstract_id": "25963602", "label": "background", "text": "Reducing consumption of food away from home is often targeted during pediatric obesity treatment , given the associations with weight status and gain .", "sentence_id": 0}
+{"abstract_id": "25963602", "label": "background", "text": "However , the effects of this dietary change on weight loss are unknown .", "sentence_id": 1}
+{"abstract_id": "25963602", "label": "objective", "text": "Our aim was to evaluate associations between changes in dietary factors and child anthropometric outcomes after treatment .", "sentence_id": 2}
+{"abstract_id": "25963602", "label": "objective", "text": "It is hypothesized that reduced consumption of food away from home will be associated with improved dietary intake and greater reductions in anthropometric outcomes ( standardized body mass index -LSB- BMI -RSB- and percent body fat ) , and the relationship between food away from home and anthropometric outcomes will be mediated by improved child dietary intake .", "sentence_id": 3}
+{"abstract_id": "25963602", "label": "methods", "text": "We conducted a longitudinal evaluation of associations between dietary changes and child anthropometric outcomes .", "sentence_id": 4}
+{"abstract_id": "25963602", "label": "methods", "text": "Child diet ( three @-hour recalls ) and anthropometric data were collected at baseline and @ weeks .", "sentence_id": 5}
+{"abstract_id": "25963602", "label": "methods", "text": "Participants were @ overweight and obese children ages @ to @ years who completed a @-week family-based behavioral weight-loss treatment as part of a larger multi-site randomized controlled trial conducted in two cohorts between @ and @ ( clinical research trial ) .", "sentence_id": 6}
+{"abstract_id": "25963602", "label": "methods", "text": "Dietary treatment targets during family-based behavioral weight-loss treatment included improving diet quality and reducing food away from home .", "sentence_id": 7}
+{"abstract_id": "25963602", "label": "methods", "text": "The main outcome measures in this study were child relative weight ( standardized BMI ) and body composition ( percent body fat ) .", "sentence_id": 8}
+{"abstract_id": "25963602", "label": "methods", "text": "We performed t tests and bootstrapped single-mediation analyses adjusting for relevant covariates .", "sentence_id": 9}
+{"abstract_id": "25963602", "label": "results", "text": "As hypothesized , decreased food away from home was associated with improved diet quality and greater reductions in standardized BMI ( P < @ ) and percent body fat ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25963602", "label": "results", "text": "Associations between food away from home and anthropometric outcomes were mediated by changes in diet quality .", "sentence_id": 11}
+{"abstract_id": "25963602", "label": "results", "text": "Specifically , change in total energy intake and added sugars mediated the association between change in food away from home and standardized BMI , and change in overall diet quality , fiber , added sugars , and added fats mediated the association between change in food away from home and percent body fat .", "sentence_id": 12}
+{"abstract_id": "25963602", "label": "results", "text": "Including physical activity as a covariate did not significantly impact these findings .", "sentence_id": 13}
+{"abstract_id": "25963602", "label": "conclusions", "text": "These results suggest that reducing food away from home can be an important behavioral target for affecting positive changes in both diet quality and anthropometric outcomes during treatment .", "sentence_id": 14}
+{"abstract_id": "24767956", "label": "background", "text": "Music has been employed in various clinical settings to reduce anxiety .", "sentence_id": 0}
+{"abstract_id": "24767956", "label": "background", "text": "However , meta-analysis has shown music to have little influence on haemodynamic parameters .", "sentence_id": 1}
+{"abstract_id": "24767956", "label": "background", "text": "This study aimed at investigating the effect of relaxing music on heart rate recovery after exercise .", "sentence_id": 2}
+{"abstract_id": "24767956", "label": "methods", "text": "Twenty-three student volunteers underwent treadmill exercise and were assessed for heart rate recovery and saliva analysis ; comparing exposure to sedative music with exposure to silence during the recovery period immediately following exercise .", "sentence_id": 3}
+{"abstract_id": "24767956", "label": "results", "text": "No differences were found between music and non-music exposure regarding : heart rate recovery , resting pulse rate , and salivary cortisol .", "sentence_id": 4}
+{"abstract_id": "24767956", "label": "results", "text": "Music was no different to silence in affecting these physiological measures , which are all associated with anxiety .", "sentence_id": 5}
+{"abstract_id": "24767956", "label": "conclusions", "text": "Relaxing music unaccompanied by meditation techniques or other such interventions may not have a major role in reducing anxiety in certain experimental settings .", "sentence_id": 6}
+{"abstract_id": "24254035", "label": "background", "text": "Fatigue is one problem that is seen in high numbers in hemodialysis patients .", "sentence_id": 0}
+{"abstract_id": "24254035", "label": "background", "text": "Fatigue decreases quality of life by negatively affecting an individual 's daily performance , activities , professional life , relations with family and friends , and treatment process .", "sentence_id": 1}
+{"abstract_id": "24254035", "label": "objective", "text": "This study was carried out to determine the effect of acupressure on the level of fatigue in hemodialysis patients .", "sentence_id": 2}
+{"abstract_id": "24254035", "label": "methods", "text": "The study was conducted as experimental research with an acupressure ( intervention ) group and a control group .", "sentence_id": 3}
+{"abstract_id": "24254035", "label": "methods", "text": "The research , for which an ethics committee 's approval and institutional permission was obtained , was conducted in two central provinces of Turkey , Nevehir and Aksaray , at two hemodialysis centers with similar characteristics .", "sentence_id": 4}
+{"abstract_id": "24254035", "label": "methods", "text": "The research was completed with a total of @ participants ( @ in the intervention group and @ in the control group ) who met the inclusion criteria .", "sentence_id": 5}
+{"abstract_id": "24254035", "label": "methods", "text": "A total of @ acupressure sessions , @ / wk for @ mo , were performed for all participants in the intervention group , as required by the acupressure application protocol , applying acupressure at the Stomach @ ( ST-@ ) , Gallbladder @ ( GB-@ ) , Spleen @ ( SP-@ ) , and Kidney @ ( K-@ ) acupuncture points with a transcutaneous electrical nerve stimulation ( TENS ) acupuncture pen ( XFT-@ acupuncture pen , Shenzhen Xunfegtong Electronics Co , Ltd , Shenzhen , China ) .", "sentence_id": 6}
+{"abstract_id": "24254035", "label": "methods", "text": "A visual analog scale ( VAS ) for fatigue and the Piper Fatigue Scale ( PFS ) were used to evaluate the fatigue level of the participants before and after the acupressure application .", "sentence_id": 7}
+{"abstract_id": "24254035", "label": "results", "text": "After the acupressure applications for @ mo , the subscale and total fatigue scores for the VAS ( P < @ ) and PFS were lower ( P < @ ) for participants in the intervention group compared to the controls , except for the cognitive subscale on the PFS ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24254035", "label": "conclusions", "text": "The study found that acupressure , applied using an acupuncture pen , was effective in decreasing fatigue in hemodialysis patients .", "sentence_id": 9}
+{"abstract_id": "24254035", "label": "conclusions", "text": "Based on this result , the current research team suggests that hemodialysis patients and nurses should be informed about acupressure application so as to extend the use of acupressure in reducing fatigue symptoms .", "sentence_id": 10}
+{"abstract_id": "25944606", "label": "objective", "text": "The aim of our study was to measure the volume of gestational sac and amniotic sac in physiological pregnancies and missed abortion .", "sentence_id": 0}
+{"abstract_id": "25944606", "label": "objective", "text": "We wanted to create nomograms for individual weeks of gestation .", "sentence_id": 1}
+{"abstract_id": "25944606", "label": "methods", "text": "Retrospective cohort study .", "sentence_id": 2}
+{"abstract_id": "25944606", "label": "methods", "text": "Institute for the Care of Mother and Child , Prague .", "sentence_id": 3}
+{"abstract_id": "25944606", "label": "methods", "text": "The study randomized @ women after spontaneous conception .", "sentence_id": 4}
+{"abstract_id": "25944606", "label": "methods", "text": "The patients were divided into two groups : women with physiological pregnancy and childbirth in the period ( @ ) , and women with pregnancy terminated by missed abortion .", "sentence_id": 5}
+{"abstract_id": "25944606", "label": "methods", "text": "Both groups were performed measurement volume of gestational and amniotic sac in the first trimester of pregnancy .", "sentence_id": 6}
+{"abstract_id": "25944606", "label": "methods", "text": "Analysis was performed using @D View software applications , and volume calculations were performed using VOCAL ( Virtual Organ Computer Aided anaLysis ) .", "sentence_id": 7}
+{"abstract_id": "25944606", "label": "results", "text": "We have created the first in the Czech Republic nomograms volumes of gestational and amniotic sac in physiological pregnancies and missed abortion .", "sentence_id": 8}
+{"abstract_id": "25944606", "label": "results", "text": "We performed a correlation between the size of gestational sac and prosperity pregnancy .", "sentence_id": 9}
+{"abstract_id": "25944606", "label": "conclusions", "text": "In our study we found no correlation between the volume of gestational sac and the development of the pregnancy .", "sentence_id": 10}
+{"abstract_id": "26115386", "label": "objective", "text": "To evaluate the effect of structured physical activity on sleep-wake behaviors in sedentary community-dwelling elderly adults with mobility limitations .", "sentence_id": 0}
+{"abstract_id": "26115386", "label": "methods", "text": "Multicenter , randomized trial of moderate-intensity physical activity versus health education , with sleep-wake behaviors prespecified as a tertiary outcome over a planned intervention period ranging from @ to @ months .", "sentence_id": 1}
+{"abstract_id": "26115386", "label": "methods", "text": "Lifestyle Interventions and Independence for Elders Study .", "sentence_id": 2}
+{"abstract_id": "26115386", "label": "methods", "text": "Community-dwelling persons aged @ to @ who were initially sedentary and had a Short Physical Performance Battery score less than @ ( N = @,@ ) .", "sentence_id": 3}
+{"abstract_id": "26115386", "label": "methods", "text": "Sleep-wake behaviors were evaluated using the Insomnia Severity Index ( ISI ) ( @ defined insomnia ) , Epworth Sleepiness Scale ( ESS ) ( @ defined daytime drowsiness ) , and Pittsburgh Sleep Quality Index ( PSQI ) ( > @ defined poor sleep quality ) administered at baseline and @ , @ , and @ months .", "sentence_id": 4}
+{"abstract_id": "26115386", "label": "results", "text": "The randomized groups were similar in terms of baseline demographic variables , including mean age ( @ ) and sex ( @ % female ) .", "sentence_id": 5}
+{"abstract_id": "26115386", "label": "results", "text": "Structured physical activity resulted in a significantly lower likelihood of having poor sleep quality ( adjusted odds ratios ( aOR ) for PSQI > @ = @ , @ % confidence interval ( CI ) = @-@ @ ) , including fewer new cases ( aOR for PSQI > @ = @ , @ % CI = @-@ @ ) , than health education but not in resolution of prevalent cases ( aOR for PSQI @ = @ , @ % CI = @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "26115386", "label": "results", "text": "No significant intervention effects were observed for the ISI or ESS .", "sentence_id": 7}
+{"abstract_id": "26115386", "label": "conclusions", "text": "Structured physical activity resulted in a lower likelihood of developing poor sleep quality ( PSQI > @ ) over the intervention period than health education but had no effect on prevalent cases of poor sleep quality or on sleep-wake behaviors evaluated using the ISI or ESS .", "sentence_id": 8}
+{"abstract_id": "26115386", "label": "conclusions", "text": "These results suggest that the benefit of physical activity in this sample was preventive and limited to sleep-wake behaviors evaluated using the PSQI .", "sentence_id": 9}
+{"abstract_id": "25052238", "label": "background", "text": "The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups .", "sentence_id": 0}
+{"abstract_id": "25052238", "label": "background", "text": "This study was aimed to assess the possible efficacy of baclofen for the treatment of persistent hiccups after stroke .", "sentence_id": 1}
+{"abstract_id": "25052238", "label": "methods", "text": "In total , @ stroke patients with persistent hiccups were randomly assigned to receive baclofen ( n = @ ) or a placebo ( n = @ ) in a double-blind , parallel-group trial .", "sentence_id": 2}
+{"abstract_id": "25052238", "label": "methods", "text": "Participants in the baclofen group received @mg baclofen @ times daily for @days .", "sentence_id": 3}
+{"abstract_id": "25052238", "label": "methods", "text": "Participants assigned to the placebo group received @mg placebo @ times daily for @days .", "sentence_id": 4}
+{"abstract_id": "25052238", "label": "methods", "text": "The primary outcome measure was cessation of hiccups .", "sentence_id": 5}
+{"abstract_id": "25052238", "label": "methods", "text": "Secondary outcome measures included efficacy in the two groups and adverse events .", "sentence_id": 6}
+{"abstract_id": "25052238", "label": "results", "text": "All @ patients completed the study .", "sentence_id": 7}
+{"abstract_id": "25052238", "label": "results", "text": "The number of patients in whom the hiccups completely stopped was higher in the baclofen group than in the placebo group ( relative risk , @ ; @ % confidence interval , @-@ @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25052238", "label": "results", "text": "Furthermore , efficacy was higher in the baclofen group than in the placebo group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25052238", "label": "results", "text": "No serious adverse events were documented in either group .", "sentence_id": 10}
+{"abstract_id": "25052238", "label": "results", "text": "One case each of mild transient drowsiness and dizziness was present in the baclofen group .", "sentence_id": 11}
+{"abstract_id": "25052238", "label": "conclusions", "text": "Baclofen was more effective than a placebo for the treatment of persistent hiccups in stroke patients .", "sentence_id": 12}
+{"abstract_id": "24456999", "label": "background", "text": "A cardiac arrest can lead to hypoxic-ischaemic brain injury which can result in cognitive and emotional impairments and may negatively affect daily functioning , participation in society and quality of life .", "sentence_id": 0}
+{"abstract_id": "24456999", "label": "background", "text": "Furthermore , the impact on the family of the patient can be high .", "sentence_id": 1}
+{"abstract_id": "24456999", "label": "background", "text": "We designed an intervention called ` Stand still , and move on ' , which is a concise , individualised , semi-structured intervention for survivors of cardiac arrest and their caregivers , consisting of between one and six face-to-face consultations provided by a trained nurse .", "sentence_id": 2}
+{"abstract_id": "24456999", "label": "background", "text": "The intervention is directed at early detection of cognitive and emotional problems , provision of information , promotion of self-management and referral to specialised care if necessary .", "sentence_id": 3}
+{"abstract_id": "24456999", "label": "background", "text": "The effectiveness of the intervention is being examined in a randomised controlled trial -LSB- ISRCTN@ -RSB- .", "sentence_id": 4}
+{"abstract_id": "24456999", "label": "background", "text": "Alongside this trial we performed a process evaluation which aims to investigate the feasibility of the intervention by assessing : @ ) the attendance and dose delivered ; @ ) performance according to protocol ; and @ ) the opinion of patients , caregivers and nurses on the intervention .", "sentence_id": 5}
+{"abstract_id": "24456999", "label": "methods", "text": "Participants of this process evaluation were @ patients allocated to the intervention group of the RCT , their @ caregivers , and six nurses who conducted the intervention .", "sentence_id": 6}
+{"abstract_id": "24456999", "label": "methods", "text": "Measurement instruments used were evaluation forms for patients and caregivers , registration and evaluation forms for nurses , and semi-structured interviews with nurses .", "sentence_id": 7}
+{"abstract_id": "24456999", "label": "results", "text": "Seventy-nine of the patients ( @ % ) allocated to the intervention group and @ caregivers ( @ % ) participated in the intervention .", "sentence_id": 8}
+{"abstract_id": "24456999", "label": "results", "text": "The mean ( SD ) number of consultations per patient was @ ( @ ) , and most consultations were conducted at the patients ' home .", "sentence_id": 9}
+{"abstract_id": "24456999", "label": "results", "text": "The intervention was performed largely according to protocol , except that the intervention usually started later than intended , consultations were longer than expected , and the topic of self-management was not regularly addressed .", "sentence_id": 10}
+{"abstract_id": "24456999", "label": "results", "text": "Patients marked the quality of the intervention with a mean score of @ and the performance of the nurse with an @ out of ten .", "sentence_id": 11}
+{"abstract_id": "24456999", "label": "results", "text": "Overall , the intervention was positively evaluated by patients , caregivers and nurses .", "sentence_id": 12}
+{"abstract_id": "24456999", "label": "conclusions", "text": "The intervention ` Stand still , and move on ' is a promising intervention which was performed largely according to protocol and seems feasible for implementation after some adaptations , if it is found to be effective .", "sentence_id": 13}
+{"abstract_id": "24639290", "label": "objective", "text": "To investigate the efficacy of bupivacaine-soaked spongostan in cesarean section wound for postoperative anxiety level , satisfaction and early postpartum depression rate .", "sentence_id": 0}
+{"abstract_id": "24639290", "label": "methods", "text": "A total of @ women , American Society of Anesthesiologists physical status I-II , scheduled to undergo general anesthesia and elective cesarean section were recruited and randomized into a study group ( n = @ ) or a control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24639290", "label": "methods", "text": "In the spongostan group , bupivacaine-soaked spongostan was placed in the cesarean section wound .", "sentence_id": 2}
+{"abstract_id": "24639290", "label": "methods", "text": "The control group did not receive spongostan , but only general postoperative care .", "sentence_id": 3}
+{"abstract_id": "24639290", "label": "methods", "text": "Maternal health was assessed using a visual analog scale for satisfaction , a visual analog scale for anxiety and the Edinburgh Postpartum Depression Scale for postpartum depression .", "sentence_id": 4}
+{"abstract_id": "24639290", "label": "methods", "text": "Also , first breast-feeding time , first mobilization time and opioid consumption were recorded and compared .", "sentence_id": 5}
+{"abstract_id": "24639290", "label": "results", "text": "The anxiety level of the spongostan group was lower than that of the control group and the difference was statistically significant at all time intervals ( @ , @ , @ , @ , @ , @ , @ and @ h , p < @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "24639290", "label": "results", "text": "Postpartum depression rate again was significantly lower in the spongostan group both on postoperative day @ and day @ ( p @ ) .", "sentence_id": 7}
+{"abstract_id": "24639290", "label": "results", "text": "All satisfaction scores were significantly higher in the spongostan group than in the control group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24639290", "label": "results", "text": "Additionally , first breast-feeding and first mobilization times were significantly shorter and opioid consumption was lower in the spongostan group ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24639290", "label": "conclusions", "text": "Placement of bupivacaine-soaked spongostan into the cesarean section wound resulted in decreased postoperative anxiety level and postpartum depression rate and increased satisfaction .", "sentence_id": 10}
+{"abstract_id": "25239078", "label": "objective", "text": "Chronic hepatitis C treatment for prior non-responders to peginterferon ( PegIFN ) / ribavirin remains suboptimal .", "sentence_id": 0}
+{"abstract_id": "25239078", "label": "objective", "text": "The MATTERHORN study evaluated regimens containing ritonavir-boosted danoprevir ( danoprevir/r ) in prior PegIFN alfa/ribavirin non-responders .", "sentence_id": 1}
+{"abstract_id": "25239078", "label": "methods", "text": "Prior partial responders ( N = @ ) were randomized to @ weeks of twice-daily danoprevir/r @/@mg , mericitabine @ mg and ribavirin @/@ mg ( IFN-free ) ; danoprevir/r plus PegIFN alfa-@a / ribavirin ( triple ) ; or danoprevir/r , mericitabine and PegIFN alfa-@a / ribavirin ( Quad ) .", "sentence_id": 2}
+{"abstract_id": "25239078", "label": "methods", "text": "Prior null responders ( N = @ ) were randomized to @ weeks of IFN-free therapy , or quad alone ( Quad @ ) or quad plus @-weeks of PegIFN alfa-@a / ribavirin ( Quad @ ) .", "sentence_id": 3}
+{"abstract_id": "25239078", "label": "methods", "text": "The primary endpoint was sustained virological response ( HCV RNA < @ IU/ml ) @ weeks after end-of-treatment ( SVR@ ) .", "sentence_id": 4}
+{"abstract_id": "25239078", "label": "methods", "text": "Due to high relapse rates , genotype ( G ) @a patients in IFN-free arms were offered additional PegIFN alfa-@a / ribavirin .", "sentence_id": 5}
+{"abstract_id": "25239078", "label": "results", "text": "Among prior partial responders , SVR@ rates were @ % , @ % , and @ % , in the IFN-free , Triple and Quad arms , respectively ; among prior null responders , SVR@ rates were @ % , @ % , and @ % respectively .", "sentence_id": 6}
+{"abstract_id": "25239078", "label": "results", "text": "Relapse rates were lower and SVR@ rates higher in G@b-infected than G@a-infected patients .", "sentence_id": 7}
+{"abstract_id": "25239078", "label": "results", "text": "SVR@ rates in G@a and G@b patients randomized to Quad were @ % and @ % , respectively , in the partial Quad arm , and @ % and @ % , respectively , in the null Quad @ arm .", "sentence_id": 8}
+{"abstract_id": "25239078", "label": "results", "text": "Treatment failure was associated with resistance to danoprevir , but not to mericitabine , and was more common in G@a infected patients .", "sentence_id": 9}
+{"abstract_id": "25239078", "label": "results", "text": "Treatment was well-tolerated .", "sentence_id": 10}
+{"abstract_id": "25239078", "label": "conclusions", "text": "Danoprevir/r , mericitabine plus PegIFN alfa-@a / ribavirin was well-tolerated and produced high overall SVR@ rates in prior partial and null responders to PegIFN alfa/ribavirin .", "sentence_id": 11}
+{"abstract_id": "25239078", "label": "conclusions", "text": "In contrast , IFN-free regimens were associated with unacceptably high relapse rates .", "sentence_id": 12}
+{"abstract_id": "24411718", "label": "background", "text": "Long chain omega-@ polyunsaturated fatty acids ( LC n-@ PUFA ) such as EPA and DHA have been shown to possess beneficial health effects , and it is believed that many of their effects are mediated by their oxygenated products ( oxylipins ) .", "sentence_id": 0}
+{"abstract_id": "24411718", "label": "background", "text": "Recently , we have shown that serum levels of several hydroxy , epoxy , and dihydroxy FAs are dependent on the individual status of the parent FAs in a cohort of normo - and hyperlipidemic subjects .", "sentence_id": 1}
+{"abstract_id": "24411718", "label": "background", "text": "So far , the effect of an increased dietary LC n-@ PUFA intake on hydroxy , epoxy , and dihydroxy FA levels has not been investigated in subjects with mild combined hyperlipidemia .", "sentence_id": 2}
+{"abstract_id": "24411718", "label": "methods", "text": "In the present study , we compared oxylipin patterns of @ hyperlipidemic ( cholesterol > @mg/dl ; triglyceride > @mg/ml ) and @ normolipidemic men in response to twelve weeks of LC n-@ PUFA intake ( @ g DHA and @ g EPA ) .", "sentence_id": 3}
+{"abstract_id": "24411718", "label": "methods", "text": "Levels of @ free hydroxy , epoxy and dihydroxy FAs were analyzed in serum by LC-MS .", "sentence_id": 4}
+{"abstract_id": "24411718", "label": "methods", "text": "Additionally , oxylipin levels were compared with their parent PUFA levels in erythrocyte membranes ; a biomarker for the individual PUFA status .", "sentence_id": 5}
+{"abstract_id": "24411718", "label": "results", "text": "Differences in the oxylipin pattern between normo - and hyperlipidemic subjects were minor before and after treatment .", "sentence_id": 6}
+{"abstract_id": "24411718", "label": "results", "text": "In all subjects , levels of EPA-derived oxylipins ( @-@pM ) were considerably elevated after LC n-@ PUFA intake ( @-@ % ) , the increase of DHA-derived oxylipins ( @-@pM ) was less pronounced ( @-@ % ) .", "sentence_id": 7}
+{"abstract_id": "24411718", "label": "results", "text": "The relative change of EPA in erythrocyte membranes is strongly correlated ( r@ @ ; p < @ ) with the relative change of corresponding epoxy and dihydroxy FA serum levels .", "sentence_id": 8}
+{"abstract_id": "24411718", "label": "results", "text": "The effect on arachidonic acid ( AA ) - derived oxylipin levels ( @-@ ,@ pM ) was inconsistent .", "sentence_id": 9}
+{"abstract_id": "24411718", "label": "conclusions", "text": "The dietary LC PUFA composition has a direct influence on the endogenous oxylipin profile , including several highly biological active EPA - and DHA-derived lipid mediators .", "sentence_id": 10}
+{"abstract_id": "24411718", "label": "conclusions", "text": "The shift in oxylipin pattern appears to be dependent on the initial LC PUFA status particularly for EPA .", "sentence_id": 11}
+{"abstract_id": "24411718", "label": "conclusions", "text": "The finding that also levels of other oxylipins derived from ALA , LA or AA are modified by LC n-@ PUFA intake might suggest that at least some of the effects of EPA and DHA could be mediated by a shift in the entire oxylipin profile .", "sentence_id": 12}
+{"abstract_id": "25711322", "label": "objective", "text": "A small subset of HIV-positive adults have low HIV RNA in the absence of therapy , sometimes for years .", "sentence_id": 0}
+{"abstract_id": "25711322", "label": "objective", "text": "Clinical factors associated with low HIV RNA in early infection have not been well defined .", "sentence_id": 1}
+{"abstract_id": "25711322", "label": "methods", "text": "We assessed factors associated with low plasma HIV RNA level at study entry in the Strategic Timing of AntiRetroviral Treatment ( START ) trial .", "sentence_id": 2}
+{"abstract_id": "25711322", "label": "methods", "text": "All START participants had a baseline HIV RNA assessment within @ days prior to randomization .", "sentence_id": 3}
+{"abstract_id": "25711322", "label": "methods", "text": "The key covariables considered for this analysis were race , and hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) status .", "sentence_id": 4}
+{"abstract_id": "25711322", "label": "methods", "text": "We assessed factors associated with HIV RNA @ and @ HIV-@ RNA copies/mL using logistic regression .", "sentence_id": 5}
+{"abstract_id": "25711322", "label": "methods", "text": "Because of the strong association between region of randomization and baseline low HIV RNA , analyses were stratified by region .", "sentence_id": 6}
+{"abstract_id": "25711322", "label": "results", "text": "We found that , of @ eligible participants randomized in START with a baseline HIV RNA assessment , @ ( @ % ) had HIV RNA @copies/mL at baseline , and a further @ ( @ % ) between @ and @copies/mL .", "sentence_id": 7}
+{"abstract_id": "25711322", "label": "results", "text": "We found that HIV exposure routes other than male homosexual contact , higher high-density lipoprotein ( HDL ) cholesterol levels , higher CD@ cell counts , and higher CD@ : CD@ ratio were associated with increased odds of low HIV RNA .", "sentence_id": 8}
+{"abstract_id": "25711322", "label": "results", "text": "HCV antibody positivity was borderline statistically significantly associated with low HIV RNA .", "sentence_id": 9}
+{"abstract_id": "25711322", "label": "results", "text": "Race and HBV surface antigen positivity were not significantly associated with low HIV RNA .", "sentence_id": 10}
+{"abstract_id": "25711322", "label": "conclusions", "text": "In a modern cohort of individuals with early untreated HIV infection , we found that HIV exposure routes other than male homosexual contact and higher HDL cholesterol were associated with increased odds of low HIV RNA .", "sentence_id": 11}
+{"abstract_id": "24423823", "label": "objective", "text": "To compare the efficacy and toxicity of chemotherapy under the guidance of molecular markers and with vinorelbine in elderly patients with epidermal growth factor receptor ( EGFR ) wild-type advanced non-small cell lung cancer ( NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "24423823", "label": "methods", "text": "A total of @ elderly patients with pathologically-confirmed advanced NSCLC with EGFR wild-type were recruited between June @ to October @ .", "sentence_id": 1}
+{"abstract_id": "24423823", "label": "methods", "text": "There were @ males and @ females , aging from @ to @ years .", "sentence_id": 2}
+{"abstract_id": "24423823", "label": "methods", "text": "They were divided randomly into @ groups according to the proportion of @ : @ by SPSS @ software .", "sentence_id": 3}
+{"abstract_id": "24423823", "label": "methods", "text": "The study group received chemotherapy ( cisplatin , gemcitabine , paclitaxel , and pemetrexed ) under the guidance of molecular markers ( excision repair cross-complementing @ ERCC@ , ribonucleotide reductase M@ RRM@ , Class III beta-tubulin , thymidylate synthetase TS ) .", "sentence_id": 4}
+{"abstract_id": "24423823", "label": "methods", "text": "The control group received vinorelbine @ mg/m ( @ ) days @ and @ with @ days as a cycle .", "sentence_id": 5}
+{"abstract_id": "24423823", "label": "results", "text": "The progression-free survival ( PFS ) of the study group and the control group was @ months ( @ % CI : @-@ @ ) and @ months ( @ % CI : @-@ @ ) respectively , the difference being statistically significant ( ( @ ) = @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24423823", "label": "results", "text": "The objective response rate ( ORR ) was @ % ( @/@ ) and @ % ( @/@ ) ( ( @ ) = @ , P = @ ) , the disease control rate ( DCR ) was @ % ( @/@ ) and @ % ( @/@ ) ( ( @ ) = @ , P = @ ) , and the median overall survival ( OS ) was @ months and @ months ( ( @ ) = @ , P = @ ) , respectively ; the differences being not significant .", "sentence_id": 7}
+{"abstract_id": "24423823", "label": "results", "text": "Adverse effects were similar between the study group and the control group .", "sentence_id": 8}
+{"abstract_id": "24423823", "label": "results", "text": "The most commonly seen adverse events were hematological toxicity , nausea , vomiting , fatigue , alopecia , joint and muscle pain .", "sentence_id": 9}
+{"abstract_id": "24423823", "label": "results", "text": "Most of the toxicity was of grade I and grade II .", "sentence_id": 10}
+{"abstract_id": "24423823", "label": "results", "text": "There was no treatment-related death .", "sentence_id": 11}
+{"abstract_id": "24423823", "label": "conclusions", "text": "The PFS was prolonged in elderly patients with EGFR wild-type advanced NSCLC under the guidance of molecular markers , but there was no improvement in ORR , DCR and OS .", "sentence_id": 12}
+{"abstract_id": "24423823", "label": "conclusions", "text": "Further studies are needed to evaluate the clinical significance of this treatment modality .", "sentence_id": 13}
+{"abstract_id": "24831394", "label": "objective", "text": "To investigate the modulatory effects that dynamic hyperinflation ( DH ) , defined as a reduction in inspiratory capacity ( IC ) , has on exercise tolerance after bronchodilator in patients with COPD .", "sentence_id": 0}
+{"abstract_id": "24831394", "label": "methods", "text": "An experimental , randomized study involving @ COPD patients without severe hypoxemia .", "sentence_id": 1}
+{"abstract_id": "24831394", "label": "methods", "text": "At baseline , the patients underwent clinical assessment , spirometry , and incremental cardiopulmonary exercise testing ( CPET ) .", "sentence_id": 2}
+{"abstract_id": "24831394", "label": "methods", "text": "On two subsequent visits , the patients were randomized to receive a combination of inhaled fenoterol/ipratropium or placebo .", "sentence_id": 3}
+{"abstract_id": "24831394", "label": "methods", "text": "All patients then underwent spirometry and submaximal CPET at constant speed up to the limit of tolerance ( Tlim ) .", "sentence_id": 4}
+{"abstract_id": "24831394", "label": "methods", "text": "The patients who showed IC ( peak-rest ) < @ were considered to present with DH ( DH + ) .", "sentence_id": 5}
+{"abstract_id": "24831394", "label": "results", "text": "In this sample , @ patients ( @ % ) had DH .", "sentence_id": 6}
+{"abstract_id": "24831394", "label": "results", "text": "The DH + patients had higher airflow obstruction and lower Tlim than did the patients without DH ( DH - ) .", "sentence_id": 7}
+{"abstract_id": "24831394", "label": "results", "text": "Despite equivalent improvement in FEV@ after bronchodilator , the DH - group showed higher IC ( bronchodilator-placebo ) at rest in relation to the DH + group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24831394", "label": "results", "text": "However , this was not found in relation to IC at peak exercise between DH + and DH - groups ( @ @ L vs. @ @ L , p > @ ) .", "sentence_id": 9}
+{"abstract_id": "24831394", "label": "results", "text": "In addition , both groups showed similar improvements in Tlim after bronchodilator ( median -LSB- interquartile range -RSB- : @ % -LSB- @-@ % -RSB- vs. @ % -LSB- @-@ % -RSB- ; p > @ ) .", "sentence_id": 10}
+{"abstract_id": "24831394", "label": "conclusions", "text": "Improvement in TLim was associated with an increase in IC at rest after bronchodilator in HD - patients with COPD .", "sentence_id": 11}
+{"abstract_id": "24831394", "label": "conclusions", "text": "However , even without that improvement , COPD patients can present with greater exercise tolerance after bronchodilator provided that they develop DH during exercise .", "sentence_id": 12}
+{"abstract_id": "24394686", "label": "background", "text": "Acute otitis media ( AOM ) is a common childhood illness and the leading indication for antibiotic prescriptions for US children .", "sentence_id": 0}
+{"abstract_id": "24394686", "label": "background", "text": "Xylitol , a naturally occurring sugar alcohol , can reduce AOM when given @ times per day as a gum or syrup , but a more convenient dosing regimen is needed for widespread adoption .", "sentence_id": 1}
+{"abstract_id": "24394686", "label": "methods", "text": "We designed a pragmatic practice-based randomized controlled trial to determine if viscous xylitol solution at a dose of @ g @ times per day could reduce the occurrence of clinically diagnosed AOM among otitis-prone children @ months through @ years of age .", "sentence_id": 2}
+{"abstract_id": "24394686", "label": "results", "text": "A total of @ subjects were enrolled , with @ allocated to xylitol and @ to placebo .", "sentence_id": 3}
+{"abstract_id": "24394686", "label": "results", "text": "In the primary analysis of time to first clinically diagnosed AOM episode , the hazard ratio for xylitol versus placebo recipients was @ ( @ % confidence interval -LSB- CI -RSB- @ to @ ) .", "sentence_id": 4}
+{"abstract_id": "24394686", "label": "results", "text": "In secondary analyses , the incidence of AOM was @ episodes per @ days in the xylitol group versus @ in the placebo group ( difference @ ; @ % CI -@ to @ ) ; total antibiotic use was @ days per @ days in the xylitol group versus @ in the placebo group ( difference @ ; @ % CI -@ to @ ) .", "sentence_id": 5}
+{"abstract_id": "24394686", "label": "results", "text": "The lack of effectiveness was not explained by nonadherence to treatment , as the hazard ratio for those taking nearly all assigned xylitol compared with those taking none was @ ( @ % CI @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "24394686", "label": "conclusions", "text": "Viscous xylitol solution in a dose of @ g @ times per day was ineffective in reducing clinically diagnosed AOM among otitis-prone children .", "sentence_id": 7}
+{"abstract_id": "24374549", "label": "objective", "text": "To compare efficacy and safety of thromboprophylaxis with semuloparin started postoperatively versus enoxaparin started preoperatively in major abdominal surgery .", "sentence_id": 0}
+{"abstract_id": "24374549", "label": "background", "text": "Venous thromboembolism is an important complication following major abdominal surgery .", "sentence_id": 1}
+{"abstract_id": "24374549", "label": "background", "text": "Semuloparin is a novel ultra-low-molecular-weight heparin with high antifactor Xa and minimal antifactor IIa activity .", "sentence_id": 2}
+{"abstract_id": "24374549", "label": "methods", "text": "In this double-blind noninferiority trial , adult patients undergoing major abdominal or pelvic operation under general anesthesia lasting more than @ minutes were assigned to either daily enoxaparin @ mg commenced preoperatively or daily semuloparin @ mg commenced postoperatively , for @ to @ days .", "sentence_id": 3}
+{"abstract_id": "24374549", "label": "methods", "text": "Patients underwent bilateral leg venography between @ and @ days postsurgery .", "sentence_id": 4}
+{"abstract_id": "24374549", "label": "methods", "text": "The primary efficacy end point was the composite of any deep vein thrombosis , nonfatal pulmonary embolism , or all-cause death .", "sentence_id": 5}
+{"abstract_id": "24374549", "label": "methods", "text": "The primary safety outcome was bleeding .", "sentence_id": 6}
+{"abstract_id": "24374549", "label": "methods", "text": "Both were independently adjudicated .", "sentence_id": 7}
+{"abstract_id": "24374549", "label": "results", "text": "In total , @ patients were randomized ; @ ( @ in the enoxaparin and @ in the semuloparin groups ) were evaluable for the primary efficacy end point , which occurred in @ patients ( @ % ) in the semuloparin group and @ patients ( @ % ) in the enoxaparin group -LSB- odds ratio ( OR ) = @ , @ % confidence interval ( CI ) : @-@ @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "24374549", "label": "results", "text": "On the basis of a noninferiority margin of @ , postoperative semuloparin did not demonstrate noninferiority to preoperative enoxaparin .", "sentence_id": 9}
+{"abstract_id": "24374549", "label": "results", "text": "Major bleeding occurred in @ of @ patients ( @ % ) in the semuloparin group and @ of @ patients ( @ % ) in the enoxaparin group ( OR = @ , @ % CI : @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24374549", "label": "conclusions", "text": "Semuloparin commenced postoperatively did not demonstrate noninferiority to enoxaparin initiated preoperatively for thromboprophylaxis after major abdominal surgery .", "sentence_id": 11}
+{"abstract_id": "24374549", "label": "conclusions", "text": "Study registered with clinicaltrials.gov : NCT@ .", "sentence_id": 12}
+{"abstract_id": "25375851", "label": "objective", "text": "To compare visual outcome , higher-order aberrations , and corneal asphericity ( Q value ) between wavefront-guided and aspheric LASIK for myopia and myopic astigmatism .", "sentence_id": 0}
+{"abstract_id": "25375851", "label": "methods", "text": "Forty patients were randomly selected to receive wavefront-guided LASIK ( wavefront-guided group ) or aspheric LASIK ( aspheric group ) ( @ eyes of @ patients in each group ) using the Technolas @z excimer laser platform ( Bausch & Lomb , Rochester , NY ) .", "sentence_id": 1}
+{"abstract_id": "25375851", "label": "methods", "text": "Flaps were created using the Zyoptix XP microkeratome ( Bausch & Lomb ) .", "sentence_id": 2}
+{"abstract_id": "25375851", "label": "methods", "text": "Preoperative and postoperative evaluation included uncorrected distance visual acuity ( UDVA ) , corneal topography , wavefront aberrometry , and contrast sensitivity .", "sentence_id": 3}
+{"abstract_id": "25375851", "label": "methods", "text": "Minimum follow-up period was @ months .", "sentence_id": 4}
+{"abstract_id": "25375851", "label": "results", "text": "At @ months postoperatively , the aspheric group had significantly better UDVA ( logMAR @ @ -LSB- Snellen @/@ -RSB- -LSB- range : -@ to @ -RSB- ) and lower mean residual spherical error ( +@ @ diopters -LSB- D -RSB- -LSB- range : -@ to @ D -RSB- ) than the wavefront-guided group ( logMAR UDVA @ @ -LSB- range : -@ to @ -RSB- ; MRSE -@ @ D -LSB- range : -@ to @ D -RSB- ) ( P = @ and < @ , respectively ) .", "sentence_id": 5}
+{"abstract_id": "25375851", "label": "results", "text": "Mean change in higher-order aberration root mean square at @ months postoperatively ( @-mm pupil ) was @ @ m after aspheric LASIK and @ @ m after wavefront-guided LASIK ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25375851", "label": "results", "text": "Aspheric LASIK induced minimal change in spherical aberrations postoperatively ( @ @ m , P = @ ) , unlike wavefront-guided LASIK ( @ @ m , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25375851", "label": "results", "text": "Change in Q value was significantly less in the aspheric group ( @ @ ) than the wavefront-guided group ( @ @ ) ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25375851", "label": "results", "text": "The aspheric group had significant improvement in contrast sensitivity at all spatial frequencies ( P < @ ) , whereas the wavefront-guided group showed a slight decrease at higher spatial frequency ( @ cycles per degree ) .", "sentence_id": 9}
+{"abstract_id": "25375851", "label": "conclusions", "text": "Aspheric LASIK induced significantly less change in higher-order aberrations and maintained corneal asphericity better than wavefront-guided LASIK .", "sentence_id": 10}
+{"abstract_id": "25375851", "label": "conclusions", "text": "The visual outcome and contrast sensitivity was better in the aspheric group at @ months postoperatively .", "sentence_id": 11}
+{"abstract_id": "25029424", "label": "background", "text": "Hyperparathyroidism occurs frequently in X-linked hypophosphatemia ( XLH ) and may exacerbate phosphaturia , potentially affecting skeletal abnormalities .", "sentence_id": 0}
+{"abstract_id": "25029424", "label": "objective", "text": "The objective of the study was to suppress elevated PTH levels in XLH patients .", "sentence_id": 1}
+{"abstract_id": "25029424", "label": "methods", "text": "This was a prospective , randomized , placebo-controlled , double-blind , @-year trial of paricalcitol , with outcomes measured at entry and @ year later .", "sentence_id": 2}
+{"abstract_id": "25029424", "label": "methods", "text": "PATIENTS were recruited from the investigators ' clinics or referred from throughout the United States .", "sentence_id": 3}
+{"abstract_id": "25029424", "label": "methods", "text": "Data were collected in an in-patient hospital research unit .", "sentence_id": 4}
+{"abstract_id": "25029424", "label": "methods", "text": "Subjects with a clinical diagnosis of XLH and hyperparathyroidism were offered participation and were eligible if they were @ years old or older and not pregnant , and their serum calcium level was less than @ mg/dL , their @-hydroxyvitamin D level was @ ng/mL or greater , and their creatinine level was @ mg/dL or less .", "sentence_id": 5}
+{"abstract_id": "25029424", "label": "methods", "text": "The intervention for this study was the use of paricalcitol or placebo for @ year .", "sentence_id": 6}
+{"abstract_id": "25029424", "label": "methods", "text": "Determined prior to trial onset was the change in PTH area under the curve .", "sentence_id": 7}
+{"abstract_id": "25029424", "label": "methods", "text": "Secondary outcomes included renal phosphate threshold per glomerular filtration rate , serum phosphorus , serum alkaline phosphatase activity , and ( @m ) Tc-methylenediphosphonate bone scans .", "sentence_id": 8}
+{"abstract_id": "25029424", "label": "results", "text": "PTH area under the curve decreased @ % with paricalcitol , differing ( P = @ ) from the @ % increase with placebo .", "sentence_id": 9}
+{"abstract_id": "25029424", "label": "results", "text": "The renal phosphate threshold per glomerular filtration rate increased @ % with paricalcitol and decreased @ % with placebo ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25029424", "label": "results", "text": "Serum phosphorus increased @ % with paricalcitol but did not differ from placebo .", "sentence_id": 11}
+{"abstract_id": "25029424", "label": "results", "text": "Paricalcitol decreased alkaline phosphatase activity in adults by @ % ( no change with placebo , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25029424", "label": "results", "text": "Bone scans improved in @ of @ paricalcitol subjects , whereas no placebo-treated subject improved .", "sentence_id": 13}
+{"abstract_id": "25029424", "label": "results", "text": "Hypercalciuria developed in six paricalcitol subjects and persisted from baseline in one placebo subject .", "sentence_id": 14}
+{"abstract_id": "25029424", "label": "conclusions", "text": "Suppression of PTH may be a useful strategy for skeletal improvement in XLH patients with hyperparathyroidism , and paricalcitol appears to be an effective adjunct to standard therapy in this setting .", "sentence_id": 15}
+{"abstract_id": "25029424", "label": "conclusions", "text": "Although paricalcitol was well tolerated , urinary calcium and serum calcium and creatinine should be monitored closely with its use .", "sentence_id": 16}
+{"abstract_id": "25319187", "label": "background", "text": "Whether the type of dietary fat could alter cardiometabolic responses to a hypercaloric diet is unknown .", "sentence_id": 0}
+{"abstract_id": "25319187", "label": "background", "text": "In addition , subclinical cardiometabolic consequences of moderate weight gain require further study .", "sentence_id": 1}
+{"abstract_id": "25319187", "label": "results", "text": "In a @-week , double-blind , parallel-group , randomized controlled trial , @ healthy , lean individuals ( mean age of @ ) consumed muffins ( @ % of energy -LSB- % E -RSB- from fat and @ % E refined carbohydrates ) providing @ kcal/day added to their habitual diets .", "sentence_id": 2}
+{"abstract_id": "25319187", "label": "results", "text": "All muffins had identical contents , except for type of fat ; sunflower oil rich in polyunsaturated fatty acids ( PUFA diet ) or palm oil rich in saturated fatty acids ( SFA diet ) .", "sentence_id": 3}
+{"abstract_id": "25319187", "label": "results", "text": "Despite comparable weight gain in the @ groups , total : high-density lipoprotein ( HDL ) cholesterol , low-density lipoprotein : HDL cholesterol , and apolipoprotein B : AI ratios decreased during the PUFA versus the SFA diet ( -@ versus +@ , -@ versus +@ , and -@ versus +@ , P = @ , P = @ , and P = @ for between-group differences ) , whereas no significant differences were observed for other cardiometabolic risk markers .", "sentence_id": 4}
+{"abstract_id": "25319187", "label": "results", "text": "In the whole group ( ie , independently of fat type ) , body weight increased ( +@ % , P < @ ) together with increased plasma proinsulin ( +@ % , P = @ ) , insulin ( +@ % , P = @ ) , proprotein convertase subtilisin/kexin type @ , ( +@ % , P = @ ) fibroblast growth factor-@ ( +@ % , P = @ ) , endothelial markers vascular cell adhesion molecule-@ , intercellular adhesion molecule-@ , and E-selectin ( +@ , +@ , and +@ % , respectively , P < @ for all ) , whereas nonesterified fatty acids decreased ( -@ % , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25319187", "label": "conclusions", "text": "Excess energy from PUFA versus SFA reduces atherogenic lipoproteins .", "sentence_id": 6}
+{"abstract_id": "25319187", "label": "conclusions", "text": "Modest weight gain in young individuals induces hyperproinsulinemia and increases biomarkers of endothelial dysfunction , effects that may be partly outweighed by the lipid-lowering effects of PUFA .", "sentence_id": 7}
+{"abstract_id": "25425394", "label": "objective", "text": "To characterize the variability in exposure and metabolic effect of insulin glargine @U/ml ( Gla-@ ) at steady state in people with type @ diabetes ( T@DM ) .", "sentence_id": 0}
+{"abstract_id": "25425394", "label": "methods", "text": "A total of @ participants with T@DM underwent two @-h euglycaemic clamps in steady-state conditions after six once-daily administrations of @ U/kg Gla-@ in a double-blind , randomized , two-treatment , two-period , crossover clamp study .", "sentence_id": 1}
+{"abstract_id": "25425394", "label": "methods", "text": "Participants were randomized to receive Gla-@ as a standard cartridge formulation in the first treatment period , and as a formulation with enhanced stability through polysorbate-@ addition in the second treatment period , or vice versa .", "sentence_id": 2}
+{"abstract_id": "25425394", "label": "methods", "text": "This design allowed the assessment of bioequivalence between formulations and , subsequently , within - and between-day variability .", "sentence_id": 3}
+{"abstract_id": "25425394", "label": "results", "text": "The cumulative exposure and effect of Gla-@ developed linearly over @h , and were evenly distributed across @ - and @-h intervals .", "sentence_id": 4}
+{"abstract_id": "25425394", "label": "results", "text": "Diurnal fluctuation in exposure ( within-day variability ) was low ; the peak-to-trough ratio of insulin concentration profiles was < @ , and both the swing and peak-to-trough fluctuation were < @ .", "sentence_id": 5}
+{"abstract_id": "25425394", "label": "results", "text": "Day-to-day reproducibility of exposure was high : the between-day within-subject coefficients of variation for total systemic exposure ( area under the serum insulin glargine concentration time curve from time @ to @h after dosing ) and maximum insulin concentration were @ % -LSB- @ % confidence interval ( CI ) @-@ -RSB- and @ % ( @ % CI @-@ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "25425394", "label": "results", "text": "Reproducibility of the metabolic effect was lower than that of exposure .", "sentence_id": 7}
+{"abstract_id": "25425394", "label": "conclusions", "text": "Gla-@ provides predictable , evenly distributed @-h coverage as a result of low fluctuation and high reproducibility in insulin exposure , and appears suitable for effective basal insulin use .", "sentence_id": 8}
+{"abstract_id": "25391355", "label": "objective", "text": "Echocardiography-guided ( EG ) lead placement at the site of latest left ventricular ( LV ) mechanical activation improves outcome in patients receiving a cardiac resynchronization therapy ( CRT ) defibrillator ( D ) .", "sentence_id": 0}
+{"abstract_id": "25391355", "label": "objective", "text": "The purpose of this study is to examine whether a strategy of EG LV lead placement equally improves outcome in CRT recipients with wide ( @ ms ) versus intermediate ( @-@ ms ) QRS duration .", "sentence_id": 1}
+{"abstract_id": "25391355", "label": "methods", "text": "Patients treated with a CRT-D in the Speckle Tracking Assisted Resynchronization Therapy for Electrode Region ( STARTER ) prospective , randomized trial ( @ EG strategy and @ routine strategy ) were followed to the endpoint of death or first appropriate CRT-D therapy .", "sentence_id": 2}
+{"abstract_id": "25391355", "label": "methods", "text": "Of the patients enrolled in STARTER , @ had QRS@ ms and @ had @ < QRS@ ms.", "sentence_id": 3}
+{"abstract_id": "25391355", "label": "results", "text": "Over a mean follow-up period of @ years , @ ( @ % ) patients died and @ ( @ % ) received appropriate CRT-D therapy .", "sentence_id": 4}
+{"abstract_id": "25391355", "label": "results", "text": "Compared to patients with QRS@ ms , patients with intermediate QRS had meaningfully worse survival free from ICD therapy ( HR = @ , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25391355", "label": "results", "text": "CRT-D therapy-free survival was significantly worse in patients with intermediate QRS duration randomized to the routine LV lead placement strategy , compared to patients with intermediate QRS duration randomized to the EG LV lead placement strategy or patients with wide QRS duration regardless of LV implantation strategy ( HR = @ , @ % confidence interval = @-@ @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25391355", "label": "results", "text": "This finding was independent in type of cardiomyopathy .", "sentence_id": 7}
+{"abstract_id": "25391355", "label": "conclusions", "text": "A strategy of EG LV lead placement improves survival free from defibrillator therapy in patients with QRS between @-@ ms to levels comparable to those of patients with QRS@ ms.", "sentence_id": 8}
+{"abstract_id": "24256677", "label": "background", "text": "After traumatic brain injury ( TBI ) , catecholamines ( CAs ) may be needed to maintain adequate cerebral perfusion pressure ( CPP ) , but there are no recommended alternative vasopressor therapies .", "sentence_id": 0}
+{"abstract_id": "24256677", "label": "background", "text": "This is an interim report of the first study to test the hypothesis that arginine vasopressin ( AVP ) is a safe and effective alternative to CAs for the management of CPP in patients with severe TBI .", "sentence_id": 1}
+{"abstract_id": "24256677", "label": "methods", "text": "Since @ , all TBI patients requiring intracranial pressure monitoring at this Level @ trauma center have been eligible for a randomized trial to receive either CA or AVP if vasopressors were required to maintain CPP greater than @ mm Hg .", "sentence_id": 2}
+{"abstract_id": "24256677", "label": "results", "text": "To date , @ patients have been consented and randomized .", "sentence_id": 3}
+{"abstract_id": "24256677", "label": "results", "text": "Demographics , vital signs , and laboratory values were similar .", "sentence_id": 4}
+{"abstract_id": "24256677", "label": "results", "text": "As treated , @ required no vasopressors and were the least severely injured group with the best outcomes .", "sentence_id": 5}
+{"abstract_id": "24256677", "label": "results", "text": "Twenty-three patients received CA ( @ % levophed , @ % dopamine , @ % phenylephrine ) and @ patients received AVP .", "sentence_id": 6}
+{"abstract_id": "24256677", "label": "results", "text": "The two vasopressor groups had similar demographics , but Injury Severity Score ( ISS ) and fluid requirements on intensive care unit Day @ were worse in the AVP versus the CA groups ( all p < @ ) before treatment .", "sentence_id": 7}
+{"abstract_id": "24256677", "label": "results", "text": "These differences indicate more severe injury with accompanying hemodynamic instability .", "sentence_id": 8}
+{"abstract_id": "24256677", "label": "results", "text": "Nevertheless , adverse events were not increased with AVP versus CA .", "sentence_id": 9}
+{"abstract_id": "24256677", "label": "results", "text": "Trends favored AVP versus CA , but no apparent differences were statistically significant at this interim point .", "sentence_id": 10}
+{"abstract_id": "24256677", "label": "results", "text": "There was no difference in mortality rates between CA and AVP .", "sentence_id": 11}
+{"abstract_id": "24256677", "label": "conclusions", "text": "These preliminary results suggest that AVP is a safe and effective alternative to CA for the management of CPP after TBI and support the continued investigation and use of AVP when vasopressors are required for CPP management in TBI patients .", "sentence_id": 12}
+{"abstract_id": "24256677", "label": "methods", "text": "Therapeutic study , level II .", "sentence_id": 13}
+{"abstract_id": "24468007", "label": "background", "text": "Artemisinin-based combination therapy ( ACT ) is widely recommended as first-line therapy for uncomplicated Plasmodium falciparum malaria worldwide .", "sentence_id": 0}
+{"abstract_id": "24468007", "label": "background", "text": "Artemisinin resistance has now been reported in Southeast Asia with a clinical phenotype manifested by slow parasite clearance .", "sentence_id": 1}
+{"abstract_id": "24468007", "label": "background", "text": "Although there are no reliable reports of artemisinin resistance in Africa , there is a need to better understand the dynamics of parasite clearance in African children treated with ACT in order to better detect the emergence of artemisinin resistance .", "sentence_id": 2}
+{"abstract_id": "24468007", "label": "methods", "text": "Data from a cohort of Ugandan children four to five years old , enrolled in a longitudinal , randomized , clinical trial comparing two leading ACT , artemether-lumefantrine ( AL ) and dihydroartemisinin-piperaquine ( DP ) , were analysed .", "sentence_id": 3}
+{"abstract_id": "24468007", "label": "methods", "text": "For all episodes of uncomplicated P. falciparum malaria over a @-month period , daily blood smears were performed for three days following the initiation of therapy .", "sentence_id": 4}
+{"abstract_id": "24468007", "label": "methods", "text": "Associations between pre-treatment variables of interest and persistent parasitaemia were estimated using multivariate , generalized , estimating equations with adjustment for repeated measures in the same patient .", "sentence_id": 5}
+{"abstract_id": "24468007", "label": "results", "text": "A total of @ children were included , resulting in @ episodes of malaria treated with AL and @ episodes treated with DP .", "sentence_id": 6}
+{"abstract_id": "24468007", "label": "results", "text": "The prevalence of parasitaemia on days @ , @ , and @ following initiation of therapy was @ , @ and @ % in those treated with AL , and @ , @ and @ % in those treated with DP .", "sentence_id": 7}
+{"abstract_id": "24468007", "label": "results", "text": "Independent risk factors for persistent parasitaemia on day @ included treatment with AL vs DP ( RR = @ , @ % CI @-@ @ , p < @ ) , having a temperature @ C vs < @ C ( RR = @ , @ % CI @-@ @ , p = @ ) and having a parasite density > @,@ / L vs < @,@ / L ( RR = @ , @ % CI @-@ @ , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24468007", "label": "results", "text": "Independent risk factors for having persistent parasitaemia on day @ included elevated temperature , higher parasite density , and being HIV infected .", "sentence_id": 9}
+{"abstract_id": "24468007", "label": "conclusions", "text": "Among Ugandan children , parasite clearance following treatment with AL or DP was excellent with only one of @ patients tested having a positive blood slide three days after initiation of therapy .", "sentence_id": 10}
+{"abstract_id": "24468007", "label": "conclusions", "text": "The type of ACT given , pre-treatment temperature , pre-treatment parasite density and HIV status were associated with differences in persistent parasitaemia , one or two days following therapy .", "sentence_id": 11}
+{"abstract_id": "24297663", "label": "background", "text": "Understanding the nature and time course of the pharmacodynamic effects of attention-deficit/hyperactivity disorder ( ADHD ) medications is useful .", "sentence_id": 0}
+{"abstract_id": "24297663", "label": "background", "text": "The Cognitive Drug Research Computerized Battery of Tests ( CDR-CBT ) is a @-min battery of ten standardized , validated neuropsychometric tasks .", "sentence_id": 1}
+{"abstract_id": "24297663", "label": "objective", "text": "This pilot study examined the sensitivity and responsiveness of the CDR-CBT for assessing cognitive function in adults with ADHD prior to and up to @ h postdose during treatment with lisdexamfetamine dimesylate ( LDX ) or mixed amphetamine salts immediate release ( MAS-IR ; various generics available ) .", "sentence_id": 2}
+{"abstract_id": "24297663", "label": "methods", "text": "This was a double-blind three-period crossover study .", "sentence_id": 3}
+{"abstract_id": "24297663", "label": "methods", "text": "Participants received LDX @ mg/day , MAS-IR @ mg/day , and placebo ( ~ @ a.m. ) for @ days each in randomized order .", "sentence_id": 4}
+{"abstract_id": "24297663", "label": "methods", "text": "CDR-CBT was administered on day @ of period @ and day @ of each period at scheduled times between -@ ( predose ) and @ h postdose .", "sentence_id": 5}
+{"abstract_id": "24297663", "label": "methods", "text": "Composite power of attention ( PoA ) score ( sum of simple reaction time , choice reaction time , and digit vigilance speed ) was the primary outcome measure .", "sentence_id": 6}
+{"abstract_id": "24297663", "label": "methods", "text": "The Conners ' Adult ADHD Rating Scales-Self-Report : Short Version ( CAARS-S : S ) was administered at baseline and on day @ of period @ , and days @ and @ of each treatment period .", "sentence_id": 7}
+{"abstract_id": "24297663", "label": "methods", "text": "Tertiary outcomes included CDR-CBT composite continuity of attention scores , its component task scores , cognitive reaction time , and response variability scores .", "sentence_id": 8}
+{"abstract_id": "24297663", "label": "methods", "text": "No inferential statistical comparisons were conducted .", "sentence_id": 9}
+{"abstract_id": "24297663", "label": "methods", "text": "Safety assessments included adverse events ( AEs ) and vital signs .", "sentence_id": 10}
+{"abstract_id": "24297663", "label": "results", "text": "This analysis included @ participants ( mean age @ years ) ; one withdrew because of AEs .", "sentence_id": 11}
+{"abstract_id": "24297663", "label": "results", "text": "Mean pretreatment PoA scores were @-@ @ ms , scores commensurate with a normative age of > @ years .", "sentence_id": 12}
+{"abstract_id": "24297663", "label": "results", "text": "Maximum reductions in PoA scores with LDX and MAS-IR occurred at @ h postdose at day @ ( least squares mean difference -LSB- @ % CI -RSB- of -@ -LSB- -@ to -@ -RSB- and -@ -LSB- -@ to @ -RSB- ms vs. placebo , respectively ) .", "sentence_id": 13}
+{"abstract_id": "24297663", "label": "results", "text": "CAARS-S : S scores were unchanged with LDX and MAS-IR ( vs. placebo ) at all postdose timepoints .", "sentence_id": 14}
+{"abstract_id": "24297663", "label": "results", "text": "Tertiary attention-related CDR-CBT outcomes were sensitive to LDX and MAS-IR ( vs. placebo ) .", "sentence_id": 15}
+{"abstract_id": "24297663", "label": "results", "text": "Treatment-emergent AEs and vital signs were consistent with previous studies in adult ADHD .", "sentence_id": 16}
+{"abstract_id": "24297663", "label": "conclusions", "text": "In adults with ADHD , PoA scores indicated impaired attention at baseline and response to treatment with LDX and MAS-IR ( vs. placebo ) , demonstrating value for measuring the time course of pharmacologic treatment effects .", "sentence_id": 17}
+{"abstract_id": "24865129", "label": "objective", "text": "To evaluate approximal caries increment among @ - to @-year-olds in a low caries prevalence area in Sweden after a @-year school-based fluoride ( F ) varnish programme with Bifluorid @ and Duraphat .", "sentence_id": 0}
+{"abstract_id": "24865129", "label": "methods", "text": "The design was a RCT study with @ adolescents , divided into following four groups : Group @ Bifluorid @ two applications/year ; Group @ Duraphat two applications/year ; Group @ Bifluorid @ four applications/year and Group @ no F varnish at school .", "sentence_id": 1}
+{"abstract_id": "24865129", "label": "methods", "text": "@ children ( @ % ) completed the study .", "sentence_id": 2}
+{"abstract_id": "24865129", "label": "methods", "text": "Approximal caries was registered on bitewing radiographs .", "sentence_id": 3}
+{"abstract_id": "24865129", "label": "results", "text": "There were no statistically significant differences in caries prevalence among the groups either at baseline or after @ years .", "sentence_id": 4}
+{"abstract_id": "24865129", "label": "results", "text": "The caries increment for Group @ was @ ( meanSD ) , @ for Group @ , @ for Group @ and @ for Group @ , with no statically significant differences either between Bifluorid @ and Duraphat with the same frequency of F varnish applications or between the F groups and the control group .", "sentence_id": 5}
+{"abstract_id": "24865129", "label": "conclusions", "text": "In an area with low caries prevalence in Sweden , the supplementary caries-preventive effect of school-based F varnish applications , to regular use of F toothpaste at home and to regular caries prevention given at the Public Dental Clinics , appears to be nonsignificant regarding approximal caries increment .", "sentence_id": 6}
+{"abstract_id": "25675061", "label": "background", "text": "Dexmedetomidine and midazolam both modulate spinal analgesia by different mechanisms , and yet , no human studies are available to compare them for postoperative analgesia after neuraxial administration .", "sentence_id": 0}
+{"abstract_id": "25675061", "label": "objective", "text": "We investigated the addition of dexmedetomidine or midazolam to intrathecal bupivacaine on the duration of effective analgesia and clinical safety profile .", "sentence_id": 1}
+{"abstract_id": "25675061", "label": "methods", "text": "Prospective , randomized , double blind , placebo controlled study .", "sentence_id": 2}
+{"abstract_id": "25675061", "label": "methods", "text": "University teaching hospital .", "sentence_id": 3}
+{"abstract_id": "25675061", "label": "methods", "text": "The study cohort included a consecutive and prospective series of patients , referred for endourological procedures .", "sentence_id": 4}
+{"abstract_id": "25675061", "label": "methods", "text": "The patients were randomly allocated into @ groups ( @ patients each ) to receive intrathecally @ mL of @ % hyperbaric bupivacaine in combination with @ mcg of dexmedetomidine ( dexmedetomidine group ) , @ mg of midazolam ( midazolam group ) or @ mL of @ % saline ( control group ) .", "sentence_id": 5}
+{"abstract_id": "25675061", "label": "methods", "text": "The groups were compared to the regression time of sensory block , duration of effective analgesia ( defined as the time interval between administration of intrathecal drug to the time of first analgesic request or a numeric rating scale = @ ) , sedation score , and side effects in the first @ hours .", "sentence_id": 6}
+{"abstract_id": "25675061", "label": "methods", "text": "One way-ANOVA , Kruskal Wallis test , and Chi-square test ( ) , significance level : P < @ .", "sentence_id": 7}
+{"abstract_id": "25675061", "label": "results", "text": "The duration of effective analgesia ( time to first analgesic request ) was significantly prolonged in the dexmedetomidine group ( @ @ minutes , P < @ ) when compared with midazolam group ( @ @ minutes ) and the control group ( @ @ minutes ) .", "sentence_id": 8}
+{"abstract_id": "25675061", "label": "results", "text": "Pairwise comparisons among the @ groups with Bonferroni adjustment revealed that patients from the dexmedetomidine group were more sedated in comparison to the midazolam and control groups at the end of the first @ minutes after intrathecal injection -LSB- ( @ ) = @ , P = @ -RSB- , with a mean rank sedation score of @ for dexmedetomidine , @ for midazolam , and @ for control .", "sentence_id": 9}
+{"abstract_id": "25675061", "label": "results", "text": "No significant differences in the side effects were observed during the study period .", "sentence_id": 10}
+{"abstract_id": "25675061", "label": "results", "text": "Midazolam did not lengthen the time of the two segment sensory regression or the time to first request analgesia .", "sentence_id": 11}
+{"abstract_id": "25675061", "label": "conclusions", "text": "The study can not be extrapolated to muscle cutting surgeries under spinal anaesthesia .", "sentence_id": 12}
+{"abstract_id": "25675061", "label": "conclusions", "text": "The addition of dexmedetomidine ( @ mcg ) to @ mL of intrathecal hyperbaric bupivacaine ( @ % ) significantly prolongs the duration of effective analgesia in comparison to @ mg midazolam or placebo ( @ % normal saline ) with a comparable incidences of side effects .", "sentence_id": 13}
+{"abstract_id": "25123170", "label": "background", "text": "Several studies have presented evidence suggesting that dairy consumption has beneficial effects on blood pressure ( BP ) in healthy subjects ; however , only a few studies have examined this possibility in patients with established essential hypertension using ambulatory blood pressure monitoring .", "sentence_id": 0}
+{"abstract_id": "25123170", "label": "background", "text": "The objective of this study was to investigate how consuming dairy products impacts mean daytime systolic and diastolic BP in men and women with mild to moderate essential hypertension .", "sentence_id": 1}
+{"abstract_id": "25123170", "label": "methods", "text": "Eighty-nine men and women with systolic BP@mm Hg and@mm Hg and diastolic BP@mm Hg were enrolled in this single-blind , randomized , cross-over , controlled study .", "sentence_id": 2}
+{"abstract_id": "25123170", "label": "methods", "text": "Participants had to incorporate three daily servings of dairy products or control products equivalent in macronutrients and sodium during four-week treatment phases .", "sentence_id": 3}
+{"abstract_id": "25123170", "label": "methods", "text": "Twenty-four hour ambulatory BP and endothelial function were assessed at screening and at the end of each dietary phase .", "sentence_id": 4}
+{"abstract_id": "25123170", "label": "results", "text": "The consumption of three daily servings of dairy products led to a significant reduction in mean daytime ambulatory systolic BP ( -@ mm Hg ; P = @ ) in men compared with readings after the control phase .", "sentence_id": 5}
+{"abstract_id": "25123170", "label": "results", "text": "In women , dairy consumption had no effect on ambulatory systolic BP .", "sentence_id": 6}
+{"abstract_id": "25123170", "label": "results", "text": "Moreover , endothelial function was significantly improved by dairy consumption in the whole cohort .", "sentence_id": 7}
+{"abstract_id": "25123170", "label": "conclusions", "text": "These data indicate that the consumption of three daily servings of dairy products have beneficial effects on daytime systolic ambulatory BP compared to a heart-healthy , dairy-free , diet in men with mild to moderate essential hypertension .", "sentence_id": 8}
+{"abstract_id": "24576874", "label": "objective", "text": "The Age-Related Eye Disease Study @ ( AREDS @ ) has shown that nutritional supplementation with antioxidants and zinc modifies the natural course of AMD .", "sentence_id": 0}
+{"abstract_id": "24576874", "label": "objective", "text": "It is presumed that the supplements exert their beneficial effects by ameliorating oxidative stress due to the scavenging of reactive oxygen species ( ROS ) .", "sentence_id": 1}
+{"abstract_id": "24576874", "label": "objective", "text": "We have shown in a human model that under oxidative stress induced by administration of lipopolysaccharide ( LPS ) the vasoconstrictor response of retinal vessels to oxygen breathing is diminished .", "sentence_id": 2}
+{"abstract_id": "24576874", "label": "objective", "text": "This reduced vascular response to hyperoxia was previously shown to be normalized by the AREDS @ supplements .", "sentence_id": 3}
+{"abstract_id": "24576874", "label": "objective", "text": "In the present study , we tested the hypothesis that the response can also be restored by a different antioxidant formulation .", "sentence_id": 4}
+{"abstract_id": "24576874", "label": "methods", "text": "This randomized , double-masked , placebo-controlled parallel group study included @ healthy volunteers .", "sentence_id": 5}
+{"abstract_id": "24576874", "label": "methods", "text": "On each study day , retinal red blood cell ( RBC ) flow and the reactivity of retinal RBC flow to hyperoxia were investigated in the absence and presence of @ ng/kg LPS .", "sentence_id": 6}
+{"abstract_id": "24576874", "label": "methods", "text": "Between the two study days , subjects received either the supplement or placebo for @ days .", "sentence_id": 7}
+{"abstract_id": "24576874", "label": "results", "text": "Before supplementation LPS reduced retinal arterial vasoconstriction ( P < @ ) and reactivity of retinal RBC flow ( P = @ ) in response to @ % oxygen breathing .", "sentence_id": 8}
+{"abstract_id": "24576874", "label": "results", "text": "Two weeks of supplementation did not affect baseline retinal RBC flow , but normalized the LPS-induced change in the response to hyperoxia .", "sentence_id": 9}
+{"abstract_id": "24576874", "label": "results", "text": "The arterial vasoconstrictor response during LPS and @ % oxygen breathing was @ @ % after administration of placebo and @ @ % after supplementation ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24576874", "label": "results", "text": "The response of RBC flow to @ % oxygen breathing during LPS was @ @ % after administration of placebo and @ @ % after supplementation ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24576874", "label": "conclusions", "text": "Our data show that the supplement used in the present study can normalize the response of retinal RBC flow to hyperoxia under LPS administration .", "sentence_id": 12}
+{"abstract_id": "24576874", "label": "conclusions", "text": "This indicates that supplementation can prevent endothelial dysfunction induced by oxidative stress , which is assumed to play a role in the pathophysiology of AMD .", "sentence_id": 13}
+{"abstract_id": "24576874", "label": "conclusions", "text": "( ClinicalTrials.gov number , NCT@ . )", "sentence_id": 14}
+{"abstract_id": "24438561", "label": "objective", "text": "The aim of this clinical study was to identify changes in pulpal blood flow ( PBF ) in human central incisors resulting from short - and long-term intrusive orthodontic forces from mini-implants .", "sentence_id": 0}
+{"abstract_id": "24438561", "label": "methods", "text": "A total of @ sound upper central and lateral incisors in @ patients scheduled for intrusion for orthodontic reasons were divided into two groups .", "sentence_id": 1}
+{"abstract_id": "24438561", "label": "methods", "text": "From each group , @ teeth were subjected to intrusive force from mini-implants ( Group @ = Light Force : @ g ; Group @ = Heavy Force : @ g ) , whereas the remaining @ contralateral teeth were not subjected to forces from mini-implants and served as controls .", "sentence_id": 2}
+{"abstract_id": "24438561", "label": "methods", "text": "Laser-Doppler flowmetry ( LDF ) measurements were recorded at baseline and at @ days and @ weeks following intrusion .", "sentence_id": 3}
+{"abstract_id": "24438561", "label": "results", "text": "PBF decreased significantly at @ days ( Light Force Group : @ @ ; Heavy Force Group : @ @ ) and then increased towards baseline at @ weeks ( Light Force Group : @ @ ; Heavy Force Group : @ @ ) following intrusion .", "sentence_id": 4}
+{"abstract_id": "24438561", "label": "conclusions", "text": "In other words , despite slight regressive changes in pulpal tissue in the short-term , PBF improved after @ weeks following intrusion by mini-implants , indicating that the changes observed in PBF is reversible , even following radical incisor intrusion .", "sentence_id": 5}
+{"abstract_id": "25016216", "label": "background", "text": "Depression during pregnancy has been demonstrated to be predictive of low birthweight , prematurity , and postpartum depression .", "sentence_id": 0}
+{"abstract_id": "25016216", "label": "background", "text": "These adverse outcomes potentially have lasting effects on maternal and child well-being .", "sentence_id": 1}
+{"abstract_id": "25016216", "label": "background", "text": "Socio-economically disadvantaged women are twice as likely as middle-class women to meet diagnostic criteria for antenatal major depression ( MDD ) , but have proven difficult to engage and retain in treatment .", "sentence_id": 2}
+{"abstract_id": "25016216", "label": "background", "text": "Collaborative care treatment models for depression have not been evaluated for racially/ethnically diverse , pregnant women on Medicaid receiving care in a public health system .", "sentence_id": 3}
+{"abstract_id": "25016216", "label": "background", "text": "This paper describes the design , methodology , culturally relevant enhancements , and implementation of a randomized controlled trial of depression care management compared to public health Maternity Support Services ( MSS ) .", "sentence_id": 4}
+{"abstract_id": "25016216", "label": "methods", "text": "Pregnant , public health patients , > @ years with a likely diagnosis of MDD or dysthymia , measured respectively by the Patient Health Questionnaire-@ ( PHQ-@ ) or the Mini-International Neuropsychiatric Interview ( MINI ) , were randomized to the intervention or to public health MSS .", "sentence_id": 5}
+{"abstract_id": "25016216", "label": "methods", "text": "The primary outcome was reduction in depression severity from baseline during pregnancy to @-months post-baseline ( one-year postpartum ) .", "sentence_id": 6}
+{"abstract_id": "25016216", "label": "results", "text": "@ women with likely MDD ( @ % ) and/or dysthymia ( @ % ) were randomized .", "sentence_id": 7}
+{"abstract_id": "25016216", "label": "results", "text": "Average age was @ years and gestational age was @ weeks ; @ % racial/ethnic minority ; @ % unmarried ; @ % no high school degree/GED ; @ % unemployed ; @ % making < $ @,@ annually ; @ % having recurrent depression ; @ % PTSD , and @ % unplanned pregnancy .", "sentence_id": 8}
+{"abstract_id": "25016216", "label": "conclusions", "text": "A collaborative care team , including a psychiatrist , psychologist , project manager , and @ social workers , met weekly , collaborated with the patients ' obstetrics providers , and monitored depression severity using an electronic tracking system .", "sentence_id": 9}
+{"abstract_id": "25016216", "label": "conclusions", "text": "Potential sustainability of the intervention within a public health system requires further study .", "sentence_id": 10}
+{"abstract_id": "25612789", "label": "objective", "text": "This pilot trial evaluated the feasibility and safety of an early discharge strategy ( EDS : @ h , followed by outpatient lifestyle interventions ) , in comparison with a conventional discharge strategy ( CDS ) for low-risk ( Zwolle risk score @ ) ST-elevation myocardial infarction ( STEMI ) patients treated with primary angioplasty .", "sentence_id": 0}
+{"abstract_id": "25612789", "label": "methods", "text": "One hundred patients were randomized to an EDS ( n = @ ) or a CDS ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25612789", "label": "methods", "text": "The primary end point was the feasibility of the EDS : ( @ ) @ % of EDS patients discharged @ h , ( @ ) @ % visited by a nurse @ days after discharge , ( @ ) @ % with @ visits by the nurse and ( @ ) @ % visited by a cardiologist @ months .", "sentence_id": 2}
+{"abstract_id": "25612789", "label": "results", "text": "The mean age was @ @ years and ejection fraction @ @ % .", "sentence_id": 3}
+{"abstract_id": "25612789", "label": "results", "text": "Eighty-six percent were male ( @ % diabetics ) .", "sentence_id": 4}
+{"abstract_id": "25612789", "label": "results", "text": "Vascular access was radial in @ % .", "sentence_id": 5}
+{"abstract_id": "25612789", "label": "results", "text": "Ischemic time was @ h in @ % .", "sentence_id": 6}
+{"abstract_id": "25612789", "label": "results", "text": "Length of stay was shorter in EDS as compared with CDS ( @ @ vs. @ @ h , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25612789", "label": "results", "text": "EDS feasibility was : ( @ ) @ % ; ( @ ) @ % ; ( @ ) @ % ; ( @ ) @ % .", "sentence_id": 8}
+{"abstract_id": "25612789", "label": "results", "text": "There were no adverse events or differences in intervention goals and quality of life between groups .", "sentence_id": 9}
+{"abstract_id": "25612789", "label": "conclusions", "text": "An EDS in low-risk STEMI patients is feasible and seems to be safe .", "sentence_id": 10}
+{"abstract_id": "25612789", "label": "conclusions", "text": "A shorter hospital stay could benefit patients and health care systems .", "sentence_id": 11}
+{"abstract_id": "25180722", "label": "background", "text": "ICU-acquired weakness ( ICU-AW ) has immediate and long-term consequences for critically ill patients .", "sentence_id": 0}
+{"abstract_id": "25180722", "label": "background", "text": "Strategies for the prevention of weakness include modification of known risk factors , such as hyperglycemia and immobility .", "sentence_id": 1}
+{"abstract_id": "25180722", "label": "background", "text": "Intensive insulin therapy ( IIT ) has been proposed to prevent critical illness polyneuropathy .", "sentence_id": 2}
+{"abstract_id": "25180722", "label": "background", "text": "However , the effect of insulin and early mobilization on clinically apparent weakness is not well known .", "sentence_id": 3}
+{"abstract_id": "25180722", "label": "methods", "text": "This is a secondary analysis of all patients with mechanical ventilation ( N = @ ) previously enrolled in a randomized controlled trial of early occupational and physical therapy vs conventional therapy , which evaluated the end point of functional independence .", "sentence_id": 4}
+{"abstract_id": "25180722", "label": "methods", "text": "Every patient had IIT and blinded muscle strength testing on hospital discharge to determine the incidence of clinically apparent weakness .", "sentence_id": 5}
+{"abstract_id": "25180722", "label": "methods", "text": "The effects of insulin dose and early mobilization on the incidence of ICU-AW were assessed .", "sentence_id": 6}
+{"abstract_id": "25180722", "label": "results", "text": "On logistic regression analyses , early mobilization and increasing insulin dose prevented the incidence of ICU-AW ( OR , @ , P = @ ; OR , @ , P = @ ; respectively ) independent of known risk factors for weakness .", "sentence_id": 7}
+{"abstract_id": "25180722", "label": "results", "text": "Early mobilization also significantly reduced insulin requirements to achieve similar glycemic goals as compared with control patients ( @ units/kg/d vs @ units/kg/d , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25180722", "label": "conclusions", "text": "The duel effect of early mobilization in reducing clinically relevant ICU-AW and promoting euglycemia suggests its potential usefulness as an alternative to IIT .", "sentence_id": 9}
+{"abstract_id": "25736340", "label": "background", "text": "The prevalence of chronic diseases such as type @ diabetes and chronic low back pain is rising .", "sentence_id": 0}
+{"abstract_id": "25736340", "label": "background", "text": "Patient empowerment is a key strategy in the management of chronic diseases .", "sentence_id": 1}
+{"abstract_id": "25736340", "label": "background", "text": "Patient empowerment can be fostered by Web-based interactive health communication applications ( IHCAs ) that combine health information with decision support , social support , and/or behavioral change support .", "sentence_id": 2}
+{"abstract_id": "25736340", "label": "background", "text": "Tailoring the content and tone of IHCAs to the needs of individual patients might improve their effectiveness .", "sentence_id": 3}
+{"abstract_id": "25736340", "label": "objective", "text": "The main objective was to test the effectiveness of a Web-based , tailored , fully automated IHCA for patients with type @ diabetes or chronic low back pain against a standard website with identical content without tailoring ( control condition ) on patients ' knowledge and empowerment .", "sentence_id": 4}
+{"abstract_id": "25736340", "label": "methods", "text": "We performed a blinded randomized trial with a parallel design .", "sentence_id": 5}
+{"abstract_id": "25736340", "label": "methods", "text": "In the intervention group , the content was delivered in dialogue form , tailored to relevant patient characteristics .", "sentence_id": 6}
+{"abstract_id": "25736340", "label": "methods", "text": "In the control group , the sections of the text were presented in a content tree without any tailoring .", "sentence_id": 7}
+{"abstract_id": "25736340", "label": "methods", "text": "Participants were recruited online and offline and were blinded to their group assignments .", "sentence_id": 8}
+{"abstract_id": "25736340", "label": "methods", "text": "Measurements were taken at baseline ( t@ ) , directly after the first visit ( t@ ) , and at @-month follow-up ( t@ ) .", "sentence_id": 9}
+{"abstract_id": "25736340", "label": "methods", "text": "The primary hypothesis was that the tailored IHCA would have larger effects on knowledge and patient empowerment ( primary outcomes ) than the control website .", "sentence_id": 10}
+{"abstract_id": "25736340", "label": "methods", "text": "The secondary outcomes were decisional conflict and preparation for decision making .", "sentence_id": 11}
+{"abstract_id": "25736340", "label": "methods", "text": "All measurements were conducted by online self-report questionnaires .", "sentence_id": 12}
+{"abstract_id": "25736340", "label": "methods", "text": "Intention-to-treat ( ITT ) and available cases ( AC ) analyses were performed for all outcomes .", "sentence_id": 13}
+{"abstract_id": "25736340", "label": "results", "text": "A total of @ users agreed to participate in the study .", "sentence_id": 14}
+{"abstract_id": "25736340", "label": "results", "text": "Of these , @ ( @ % ) had type @ diabetes and @ ( @ % ) had chronic low back pain .", "sentence_id": 15}
+{"abstract_id": "25736340", "label": "results", "text": "Usage was significantly higher in the tailored system ( mean @ minutes ) than in the control system ( mean @ minutes ; P < @ ) .", "sentence_id": 16}
+{"abstract_id": "25736340", "label": "results", "text": "Three months after system use , @ % of the sample was retained .", "sentence_id": 17}
+{"abstract_id": "25736340", "label": "results", "text": "There was no significant intervention effect in the ITT analysis .", "sentence_id": 18}
+{"abstract_id": "25736340", "label": "results", "text": "In the AC analysis , participants using the tailored system displayed significantly more knowledge at t@ ( P = @ ) and more emotional well-being ( subscale of empowerment ) at t@ ( P = @ ) .", "sentence_id": 19}
+{"abstract_id": "25736340", "label": "results", "text": "The estimated mean difference between the groups was @ ( @ % CI @-@ @ ) points for knowledge and @ ( @ % CI @-@ @ ) points for emotional well-being on a @-@ points scale .", "sentence_id": 20}
+{"abstract_id": "25736340", "label": "conclusions", "text": "The primary analysis did not support the study hypothesis .", "sentence_id": 21}
+{"abstract_id": "25736340", "label": "conclusions", "text": "However , content tailoring and interactivity may increase knowledge and reduce health-related negative effects in persons who use IHCAs .", "sentence_id": 22}
+{"abstract_id": "25736340", "label": "conclusions", "text": "There were no main effects of the intervention on other dimensions of patient empowerment or decision-related outcomes .", "sentence_id": 23}
+{"abstract_id": "25736340", "label": "conclusions", "text": "This might be due to our tailored IHCA being , at its core , an educational intervention offering health information in a personalized , empathic fashion that merely additionally provides decision support .", "sentence_id": 24}
+{"abstract_id": "25736340", "label": "conclusions", "text": "Tailoring and interactivity may not make a difference with regard to these outcomes .", "sentence_id": 25}
+{"abstract_id": "24370797", "label": "objective", "text": "In this study , we tested the hypothesis that pulmonary artery venting would decrease the incidence of atrial fibrillation after coronary artery bypass surgery .", "sentence_id": 0}
+{"abstract_id": "24370797", "label": "methods", "text": "This prospective study included @ patients who underwent complete myocardial revascularization with cardiopulmonary bypass in our department during a @-year period .", "sentence_id": 1}
+{"abstract_id": "24370797", "label": "methods", "text": "The patients were randomly divided into @ groups : group I included @ patients who underwent aortic root venting and group II included @ patients who underwent pulmonary arterial venting for decompression of the left heart .", "sentence_id": 2}
+{"abstract_id": "24370797", "label": "methods", "text": "Pre - , peri - , and postoperative risk factors for atrial fibrillation were assessed in both groups .", "sentence_id": 3}
+{"abstract_id": "24370797", "label": "results", "text": "The mean age was similar in the @ groups .", "sentence_id": 4}
+{"abstract_id": "24370797", "label": "results", "text": "The mean number of anastomoses was significantly higher in group I ( @ @ ) than in group II ( @ @ ) ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24370797", "label": "results", "text": "The mean cross-clamp time was @ @ minutes in group I and @ @ minutes in group II ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24370797", "label": "results", "text": "The mean cardiopulmonary bypass time was @ @ minutes in group I and @ @ minutes in group II ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24370797", "label": "results", "text": "The incidence of atrial fibrillation was @ % ( n = @ ) in group I and @ % ( n = @ ) in group II ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24370797", "label": "results", "text": "Multivariate regression analysis showed that pulmonary artery venting decreased the postoperative incidence of atrial fibrillation by @ % .", "sentence_id": 9}
+{"abstract_id": "24370797", "label": "conclusions", "text": "Pulmonary arterial venting may be used as an alternative to aortic root venting during on-pump coronary bypass surgery , especially in patients at high risk of postoperative atrial fibrillation .", "sentence_id": 10}
+{"abstract_id": "24521647", "label": "objective", "text": "Biapenem is a newly developed carbapenem to treat moderate and severe bacterial infections .", "sentence_id": 0}
+{"abstract_id": "24521647", "label": "objective", "text": "This multicenter , randomized , parallel-controlled clinical trial was conducted to compare the clinical efficacy , bacterial eradication rates and safety of biapenem and meropenem in the treatment of bacterial lower respiratory tract infections and urinary tract infections ( UTIs ) at nine centres in China .", "sentence_id": 1}
+{"abstract_id": "24521647", "label": "methods", "text": "Patients diagnosed with bacterial lower respiratory tract infections or UTIs were randomly assigned to receive either biapenem ( @ mg every @ h ) or meropenem ( @ mg every @ h ) by intravenous infusion for @ to @ days according to their disease severity .", "sentence_id": 2}
+{"abstract_id": "24521647", "label": "methods", "text": "The overall clinical efficacy , bacterial eradication rates and drug-related adverse reactions of biapenem and meropenem were analyzed .", "sentence_id": 3}
+{"abstract_id": "24521647", "label": "results", "text": "A total of @ enrolled cases were included in the intent-to-treat ( ITT ) analysis and safety analysis .", "sentence_id": 4}
+{"abstract_id": "24521647", "label": "results", "text": "There were no differences in demographics and baseline medical characteristics between biapenem group and meropenem group .", "sentence_id": 5}
+{"abstract_id": "24521647", "label": "results", "text": "The overall clinical efficacies of biapenem and meropenem were not significantly different , @ per cent ( @/@ ) vs. @ per cent ( @/@ ) .", "sentence_id": 6}
+{"abstract_id": "24521647", "label": "results", "text": "The overall bacterial eradication rates of biapenem and meropenem showed no significant difference , @ per cent ( @/@ ) vs. @ per cent ( @/@ ) .", "sentence_id": 7}
+{"abstract_id": "24521647", "label": "results", "text": "Drug-related adverse reactions were comparable in biapenem and meropenem groups with the incidence of @ per cent ( @/@ ) and @ per cent ( @/@ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "24521647", "label": "results", "text": "The most common symptoms of biapenem-related adverse reactions were rash ( @ % ) and gastrointestinal distress ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24521647", "label": "conclusions", "text": "Biapenem was non-inferior to meropenem and was well-tolerated in the treatment of moderate and severe lower respiratory tract infections and UTIs .", "sentence_id": 10}
+{"abstract_id": "24666767", "label": "background", "text": "Early negative postoperative behavior ( e-PONB ) is common in children and manifests itself as emergence agitation ( EA ) , emergence delirium ( ED ) , and pain .", "sentence_id": 0}
+{"abstract_id": "24666767", "label": "background", "text": "The objective of this prospective double blind , randomized , placebo-controlled trial was to determine whether IV clonidine or IV fentanyl prior to surgery modifies e-PONB in children .", "sentence_id": 1}
+{"abstract_id": "24666767", "label": "methods", "text": "Ninety children scheduled for subumbilical surgery under sevoflurane anesthesia supplemented with regional anesthesia were randomized to either receive IV clonidine @mcgkg ( -@ ) , IV fentanyl @mcgkg ( -@ ) or placebo ( IV saline ) before surgery .", "sentence_id": 2}
+{"abstract_id": "24666767", "label": "methods", "text": "Primary outcome measures were the incidence of EA , ED and pain during the first hour after awakening .", "sentence_id": 3}
+{"abstract_id": "24666767", "label": "methods", "text": "Secondary outcome measures were side effects such as nausea and vomiting and delayed discharge from PACU .", "sentence_id": 4}
+{"abstract_id": "24666767", "label": "results", "text": "Eighty-seven children ( n = @ per group ) completed the study .", "sentence_id": 5}
+{"abstract_id": "24666767", "label": "results", "text": "EA was present in @ children ( six clonidine , none fentanyl , and four placebo , P = @ ) whereas ED was observed in @ children ( nine clonidine , three fentanyl , and eight placebo P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24666767", "label": "results", "text": "Sixteen children who received placebo had a CHIPPS score of @ compared with nine children in fentanyl group and @ children receiving clonidine ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24666767", "label": "results", "text": "Ten children receiving fentanyl vomited during the first postoperative day , compared with six children in placebo group and none in clonidine group ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24666767", "label": "results", "text": "Discharge from PACU was not affected .", "sentence_id": 9}
+{"abstract_id": "24666767", "label": "conclusions", "text": "IV fentanyl before surgery but not IV clonidine modifies e-PONB in children undergoing lower abdominal surgery under general anesthesia supplemented with regional anesthesia .", "sentence_id": 10}
+{"abstract_id": "24666767", "label": "conclusions", "text": "The use of fentanyl in this population was also associated with reduced pain scores after awakening but with significantly greater incidence of PONV .", "sentence_id": 11}
+{"abstract_id": "25060683", "label": "background", "text": "Although pain is a common complication of endoscopic submucosal dissection ( ESD ) , management strategies are inadequate .", "sentence_id": 0}
+{"abstract_id": "25060683", "label": "background", "text": "The aim of this study was to evaluate the efficacy of topical bupivacaine and triamcinolone acetonide for abdominal pain relief and as a potential method of pain control after ESD for gastric neoplasia .", "sentence_id": 1}
+{"abstract_id": "25060683", "label": "methods", "text": "In this randomized , double-blind , placebo-controlled trial , @ eligible patients with early gastric neoplasm were randomized into one of three groups : bupivacaine ( BV ) only , bupivacaine with triamcinolone ( BV-TA ) , or placebo .", "sentence_id": 2}
+{"abstract_id": "25060683", "label": "methods", "text": "The present pain intensity ( PPI ) score and the Short-Form McGill Pain Questionnaire ( SF-MPQ ) were used to evaluate pain at @ , @ , @ , and @ h after ESD .", "sentence_id": 3}
+{"abstract_id": "25060683", "label": "results", "text": "The mean values for the @-hour PPI in the BV-TA and BV groups were lower than those of the placebo group ( @ @ and @ @ vs. @ @ , p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25060683", "label": "results", "text": "The @-hour PPI of the BV-TA group ( @ @ ) was the lowest among the three groups ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25060683", "label": "results", "text": "The total @-hour SF-MPQ score , especially in the sensory domain , was higher in the placebo group than in BV and BV-TA groups .", "sentence_id": 6}
+{"abstract_id": "25060683", "label": "results", "text": "The @-hour SF-MPQ score was the lowest in the BV-TA group .", "sentence_id": 7}
+{"abstract_id": "25060683", "label": "results", "text": "Multivariate analysis demonstrated that BV-TA injection protocol , fibrosis , and size of residual ulcer were independently associated with the PPI score at @ h.", "sentence_id": 8}
+{"abstract_id": "25060683", "label": "conclusions", "text": "Bupivacaine after ESD was effective for pain relief at @ h postoperatively .", "sentence_id": 9}
+{"abstract_id": "25060683", "label": "conclusions", "text": "Particularly , topical infiltration of bupivacaine mixed with triamcinolone acetonide was helpful for producing a more long-lasting benefit of pain relief after gastric ESD .", "sentence_id": 10}
+{"abstract_id": "24731832", "label": "objective", "text": "Physical activity is a cornerstone in therapy for patients with metabolic syndrome .", "sentence_id": 0}
+{"abstract_id": "24731832", "label": "objective", "text": "Walking and hiking in a mountain scenery represents an ideal approach to make them move .", "sentence_id": 1}
+{"abstract_id": "24731832", "label": "objective", "text": "The Austrian Moderate Altitude Study ( AMAS ) @ main study is a randomized controlled trial to investigate the cardiovascular effects of hiking at moderate altitude on patients with metabolic syndrome compared with a control group at low altitude , to assess a potential altitude-specific effect .", "sentence_id": 2}
+{"abstract_id": "24731832", "label": "methods", "text": "Seventy-one male patients with metabolic syndrome were randomly assigned to a moderate altitude group ( at @ m ) , with @ participants , or to a low altitude group ( at @ m ) , with @ participants .", "sentence_id": 3}
+{"abstract_id": "24731832", "label": "methods", "text": "The @-week vacation program included @ hiking tours ( @ per week , average duration @ hours , intensity @ % to @ % of heart rate maximum ) .", "sentence_id": 4}
+{"abstract_id": "24731832", "label": "methods", "text": "Physical parameters , performance capacity , @-hour blood pressure , and heart rate profiles were obtained before , during , and after the stay .", "sentence_id": 5}
+{"abstract_id": "24731832", "label": "results", "text": "In both groups , we found a significant mean weight loss of -@ kg ; changes in performance capacity were minor .", "sentence_id": 6}
+{"abstract_id": "24731832", "label": "results", "text": "Systolic , diastolic , and mean arterial pressures and circadian heart rate profiles were significantly reduced in both groups , with no differences between them .", "sentence_id": 7}
+{"abstract_id": "24731832", "label": "results", "text": "Consequently , the pressure-rate product was reduced as well .", "sentence_id": 8}
+{"abstract_id": "24731832", "label": "results", "text": "All study participants tolerated the vacation well without any adverse events .", "sentence_id": 9}
+{"abstract_id": "24731832", "label": "conclusions", "text": "A @-week hiking vacation at moderate or low altitude is safe for patients with metabolic syndrome and provides several improvements in their cardiovascular parameters .", "sentence_id": 10}
+{"abstract_id": "24731832", "label": "conclusions", "text": "The cardiovascular benefits achieved are more likely to be the result of regular physical activity than the altitude-specific effect of a mountain environment .", "sentence_id": 11}
+{"abstract_id": "25144818", "label": "background", "text": "Isolated limb perfusion ( ILP ) is a treatment option most commonly used in the treatment of melanoma in-transit metastases of the extremities .", "sentence_id": 0}
+{"abstract_id": "25144818", "label": "background", "text": "The principle idea is to surgically isolate a region of the body and then deliver a high concentration of a chemotherapeutic agent together with hyperthermia .", "sentence_id": 1}
+{"abstract_id": "25144818", "label": "background", "text": "There have been three randomised trials exploring whether adjuvant ILP to patients with recurrent or high-risk primary melanomas increases survival ; one of these trials has now been updated with a @-year follow-up .", "sentence_id": 2}
+{"abstract_id": "25144818", "label": "methods", "text": "The original study randomised @ patients ( between @ and @ ) with their first satellite or in-transit recurrence to either wide excision ( WE group , n = @ patients ) or to WE and adjuvant ILP ( WE+ILP group , n = @ patients ) .", "sentence_id": 3}
+{"abstract_id": "25144818", "label": "methods", "text": "Follow-up data @ years later concerning survival and cause of death was retrieved from the Swedish National Cause of Death Register .", "sentence_id": 4}
+{"abstract_id": "25144818", "label": "results", "text": "In the WE+ILP group there were @ deaths ( @ % ) due to melanoma compared with @ deaths ( @ % ) in the WE group ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25144818", "label": "results", "text": "Median melanoma-specific survival was @ months for WE+ILP compared to @ months for the WE group , an almost @ year benefit without statistical significance ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25144818", "label": "conclusions", "text": "There is no evidence that adjuvant ILP prolongs survival in patients with high-risk or recurrent melanoma ; however , the existing randomised trials are largely underpowered to detect such a difference .", "sentence_id": 7}
+{"abstract_id": "25144818", "label": "conclusions", "text": "New studies are exploring systemic immunological effects of ILP , and a combination of regional therapy and immunotherapy may serve as a rationale for new trials using ILP in the future .", "sentence_id": 8}
+{"abstract_id": "25491243", "label": "background", "text": "Automated health behavior change interventions show promise , but suffer from high attrition and disuse .", "sentence_id": 0}
+{"abstract_id": "25491243", "label": "background", "text": "The Internet abounds with thousands of personal narrative accounts of health behavior change that could not only provide useful information and motivation for others who are also trying to change , but an endless source of novel , entertaining stories that may keep participants more engaged than messages authored by interventionists .", "sentence_id": 1}
+{"abstract_id": "25491243", "label": "objective", "text": "Given a collection of relevant personal health behavior change stories gathered from the Internet , the aim of this study was to develop and evaluate an automated indexing algorithm that could select the best possible story to provide to a user to have the greatest possible impact on their attitudes toward changing a targeted health behavior , in this case weight loss .", "sentence_id": 2}
+{"abstract_id": "25491243", "label": "methods", "text": "An indexing algorithm was developed using features informed by theories from behavioral medicine together with text classification and machine learning techniques .", "sentence_id": 3}
+{"abstract_id": "25491243", "label": "methods", "text": "The algorithm was trained using a crowdsourced dataset , then evaluated in a @ between-subjects randomized pilot study .", "sentence_id": 4}
+{"abstract_id": "25491243", "label": "methods", "text": "One factor compared the effects of participants reading @ indexed stories vs @ randomly selected stories , whereas the second factor compared the medium used to tell the stories : text or animated conversational agent .", "sentence_id": 5}
+{"abstract_id": "25491243", "label": "methods", "text": "Outcome measures included changes in self-efficacy and decisional balance for weight loss before and after the stories were read .", "sentence_id": 6}
+{"abstract_id": "25491243", "label": "results", "text": "Participants were recruited from a crowdsourcing website ( N = @ ; @ % , @/@ female ; mean age @ , SD @ years ; @ % , @/@ precontemplation ; @ % , @/@ contemplation for weight loss ) .", "sentence_id": 7}
+{"abstract_id": "25491243", "label": "results", "text": "Participants who read indexed stories exhibited a significantly greater increase in self-efficacy for weight loss compared to the control group ( F@ ,@ = @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25491243", "label": "results", "text": "There were no significant effects of indexing on change in decisional balance ( F@ ,@ = @ , P = @ ) and no significant effects of medium on change in self-efficacy ( F@ ,@ = @ , P = @ ) or decisional balance ( F@ ,@ = @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25491243", "label": "conclusions", "text": "Personal stories of health behavior change can be harvested from the Internet and used directly and automatically in interventions to affect participant attitudes , such as self-efficacy for changing behavior .", "sentence_id": 10}
+{"abstract_id": "25491243", "label": "conclusions", "text": "Such approaches have the potential to provide highly tailored interventions that maximize engagement and retention with minimal intervention development effort .", "sentence_id": 11}
+{"abstract_id": "24429275", "label": "background", "text": "Many patients with asthma or chronic obstructive pulmonary disease ( COPD ) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid , but those with severe disease often respond poorly to these classes of drug .", "sentence_id": 0}
+{"abstract_id": "24429275", "label": "background", "text": "We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase @ ( PDE@ ) and PDE@ inhibitor , RPL@ for its ability to act as a bronchodilator and anti-inflammatory drug .", "sentence_id": 1}
+{"abstract_id": "24429275", "label": "methods", "text": "Between February , @ , and January , @ , we undertook four proof-of-concept clinical trials in the Netherlands , Italy , and the UK .", "sentence_id": 2}
+{"abstract_id": "24429275", "label": "methods", "text": "Nebulised RPL@ was examined in study @ for safety in @ healthy men who were randomly assigned ( @:@:@ ) to receive an inhaled dose of RPL@ ( @ mg/kg or @ mg/kg ) or placebo by a computer-generated randomisation table .", "sentence_id": 3}
+{"abstract_id": "24429275", "label": "methods", "text": "Subsequently , six non-smoking men with mild allergic asthma received single doses of RPL@ ( three received @ mg/kg and three received @ mg/kg ) in an open-label , adaptive study , and then ten men with mild allergic asthma were randomly assigned to receive placebo or RPL@ ( @ mg/kg ) by a computer-generated randomisation table for an assessment of safety , bronchodilation , and bronchoprotection .", "sentence_id": 4}
+{"abstract_id": "24429275", "label": "methods", "text": "Study @ examined the reproducibility of the bronchodilator response to a daily dose of nebulised RPL@ ( @ mg/kg ) for @ consecutive days in a single-blind ( patients masked ) , placebo-controlled study in @ men with clinically stable asthma .", "sentence_id": 5}
+{"abstract_id": "24429275", "label": "methods", "text": "The safety and bronchodilator effect of RPL@ ( @ mg/kg ) was assessed in study @ , an open-label , placebo-controlled crossover trial , in @ men with mild-to-moderate COPD .", "sentence_id": 6}
+{"abstract_id": "24429275", "label": "methods", "text": "In study @ , a placebo-controlled crossover trial , the effect of RPL@ ( @ mg/kg ) on lipopolysaccharide-induced inflammatory cell infiltration in induced sputum was investigated in @ healthy men .", "sentence_id": 7}
+{"abstract_id": "24429275", "label": "methods", "text": "In studies @ and @ , randomisation was done by computer-generated permutation with a block size of two for study @ and four for study @ .", "sentence_id": 8}
+{"abstract_id": "24429275", "label": "methods", "text": "Unless otherwise stated , participants and clinicians were masked to treatment assignment .", "sentence_id": 9}
+{"abstract_id": "24429275", "label": "methods", "text": "Analyses were by intention to treat .", "sentence_id": 10}
+{"abstract_id": "24429275", "label": "methods", "text": "All trials were registered with EudraCT , numbers @-@-@ , @-@-@ , @-@-@ , and @-@-@ .", "sentence_id": 11}
+{"abstract_id": "24429275", "label": "results", "text": "Safety was a primary endpoint of studies @ and @ and a secondary endpoint of studies @ and @ .", "sentence_id": 12}
+{"abstract_id": "24429275", "label": "results", "text": "Overall , RPL@ was well tolerated , and adverse events were generally mild and of equal frequency between placebo and active treatment groups .", "sentence_id": 13}
+{"abstract_id": "24429275", "label": "results", "text": "Efficacy was a primary endpoint of study @ and a secondary endpoint of studies @ and @ .", "sentence_id": 14}
+{"abstract_id": "24429275", "label": "results", "text": "Study @ measured change in forced expiratory volume in @ s ( FEV@ ) and provocative concentration of methacholine causing a @ % fall in FEV@ ( PC@MCh ) in participants with asthma .", "sentence_id": 15}
+{"abstract_id": "24429275", "label": "results", "text": "RPL@ produced rapid bronchodilation in patients with asthma with an FEV@ increase at @ h of @ mL ( @ % CI @-@ ; p < @ ) , which was a @ % increase from placebo , and increased the PC@MCh by @ doubling doses ( @ % CI @-@ ; p = @ ) compared with placebo .", "sentence_id": 16}
+{"abstract_id": "24429275", "label": "results", "text": "The primary endpoint of study @ was maximum FEV@ reached during @ h after dosing with RPL@ in patients with asthma .", "sentence_id": 17}
+{"abstract_id": "24429275", "label": "results", "text": "RPL@ produced a similar maximum mean increase in FEV@ from placebo on day @ ( @ mL , @ % CI @-@ ) , day @ ( @ mL , @-@ ) , and day @ ( @ mL , @-@ ; overall p < @ ) .", "sentence_id": 18}
+{"abstract_id": "24429275", "label": "results", "text": "A secondary endpoint of study @ ( patients with COPD ) was the increase from baseline in FEV@ .", "sentence_id": 19}
+{"abstract_id": "24429275", "label": "results", "text": "RPL@ produced bronchodilation with a mean maximum FEV@ increase of @ % ( SE @ ) .", "sentence_id": 20}
+{"abstract_id": "24429275", "label": "results", "text": "In healthy individuals ( study @ ) , the primary endpoint was percentage change in neutrophil counts in induced sputum @ h after lipopolysaccharide challenge .", "sentence_id": 21}
+{"abstract_id": "24429275", "label": "results", "text": "RPL@ ( @ mg/kg ) did not significantly reduce the percentage of neutrophils in sputum ( @ % in the RPL@ group vs @ % in the placebo group ; difference -@ % , @ % CI -@ to @ , p = @ ) , since RPL@ significantly reduced neutrophils ( p = @ ) and total cells ( p = @ ) to a similar degree .", "sentence_id": 22}
+{"abstract_id": "24429275", "label": "conclusions", "text": "In four exploratory studies , inhaled RPL@ is an effective and well tolerated bronchodilator , bronchoprotector , and anti-inflammatory drug and further studies will establish the full potential of this new drug for the treatment of patients with COPD or asthma .", "sentence_id": 23}
+{"abstract_id": "24447053", "label": "objective", "text": "Intensified repetitive transcranial magnetic stimulation ( rTMS ) applied to the left dorsolateral prefrontal cortex ( DLPFC ) may result in fast clinical responses in treatment resistant depression ( TRD ) .", "sentence_id": 0}
+{"abstract_id": "24447053", "label": "objective", "text": "In these kinds of patients , subgenual anterior cingulate cortex ( sgACC ) functional connectivity ( FC ) seems to be consistently disturbed .", "sentence_id": 1}
+{"abstract_id": "24447053", "label": "objective", "text": "So far , no de novo data on the relationship between sgACC FC changes and clinical efficacy of accelerated rTMS were available .", "sentence_id": 2}
+{"abstract_id": "24447053", "label": "methods", "text": "Twenty unipolar TRD patients , all at least stage III treatment resistant , were recruited in a randomized sham-controlled crossover high-frequency ( HF ) - rTMS treatment study .", "sentence_id": 3}
+{"abstract_id": "24447053", "label": "methods", "text": "Resting-state ( rs ) functional MRI scans were collected at baseline and at the end of treatment .", "sentence_id": 4}
+{"abstract_id": "24447053", "label": "results", "text": "HF-rTMS responders showed significantly stronger resting-state functional connectivity ( rsFC ) anti-correlation between the sgACC and parts of the left superior medial prefrontal cortex .", "sentence_id": 5}
+{"abstract_id": "24447053", "label": "results", "text": "After successful treatment an inverted relative strength of the anti-correlations was observed in the perigenual prefrontal cortex ( pgPFC ) .", "sentence_id": 6}
+{"abstract_id": "24447053", "label": "results", "text": "No effects on sgACC rsFC were observed in non-responders .", "sentence_id": 7}
+{"abstract_id": "24447053", "label": "conclusions", "text": "Strong rsFC anti-correlation between the sgACC and parts of the left prefrontal cortex could be indicative of a beneficial outcome .", "sentence_id": 8}
+{"abstract_id": "24447053", "label": "conclusions", "text": "Accelerated HF-rTMS treatment designs have the potential to acutely adjust deregulated sgACC neuronal networks in TRD patients .", "sentence_id": 9}
+{"abstract_id": "25428445", "label": "background", "text": "Screening Tool of Older Person 's Prescriptions ( STOPP ) and the Screening Tool to Alert doctors to Right Treatment ( START ) have been increasingly used to evaluate potentially inappropriate prescriptions ( PIPs ) and potentially prescription omissions ( PPOs ) .", "sentence_id": 0}
+{"abstract_id": "25428445", "label": "background", "text": "The impact of hospitalization on PIPs/PPOs has not been investigated in depth .", "sentence_id": 1}
+{"abstract_id": "25428445", "label": "objective", "text": "To compare the prevalence of PIPs/PPOs in elderly patients on hospital admission and discharge and to identify associated risk factors .", "sentence_id": 2}
+{"abstract_id": "25428445", "label": "methods", "text": "An acute medical geriatric division of the Tel Aviv Medical Center ( Israel ) .", "sentence_id": 3}
+{"abstract_id": "25428445", "label": "methods", "text": "This retrospective cross-sectional study included patients admitted from @/@ to @/@ aged @ years .", "sentence_id": 4}
+{"abstract_id": "25428445", "label": "methods", "text": "Data from patients ' records included demographic details , diagnoses and medications at admission and discharge .", "sentence_id": 5}
+{"abstract_id": "25428445", "label": "methods", "text": "STOPP/START criteria were applied to each patient 's record .", "sentence_id": 6}
+{"abstract_id": "25428445", "label": "methods", "text": "Prevalence of PIPs/PPOs on hospital admission and discharge .", "sentence_id": 7}
+{"abstract_id": "25428445", "label": "results", "text": "Three hundred patients were included ( mean SD age @ @ years ) .", "sentence_id": 8}
+{"abstract_id": "25428445", "label": "results", "text": "Admission PIPs prevalence was @ % ( @ patients , @ PIPs ) and it increased to @ % ( @ patients , @ PIPs ) at discharge ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25428445", "label": "results", "text": "Admission PPOs prevalence was @ % ( @ patients , @ PPOs ) and it decreased to @ % ( @ patients , @ PPOs ) at discharge ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25428445", "label": "results", "text": "Having at least one PIP/PPO at discharge but not at admission was associated with length of hospital stay ( OR @ , @ % CI @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "25428445", "label": "results", "text": "History of falls increased the risk of being a `` new PIP patient '' ( OR @ , @ % CI @-@ @ ) , whereas diabetes increased the risk of being a `` new PPO patient '' ( OR @ , @ % CI @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "25428445", "label": "conclusions", "text": "Hospitalization in a geriatric division resulted in an increase in PIPs and a decrease in PPOs .", "sentence_id": 13}
+{"abstract_id": "25428445", "label": "conclusions", "text": "Strategies to reduce PIPs need to be implemented , especially for patients with longer hospital stay and a history of falls .", "sentence_id": 14}
+{"abstract_id": "25208597", "label": "objective", "text": "Tadalafil is a potent and selective phosphodiesterase type @ inhibitor that provides effective treatment for erectile dysfunction ( ED ) .", "sentence_id": 0}
+{"abstract_id": "25208597", "label": "objective", "text": "The purpose of this study was to explore the effect of a single on-demand dose of tadalafil compared to low-dose continuous administration on regional cerebral blood flow ( rCBF ) , in patients after stroke .", "sentence_id": 1}
+{"abstract_id": "25208597", "label": "methods", "text": "Thirty consecutive male patients ( mean age @ @ years ) with ED and a history of stroke were included in the study .", "sentence_id": 2}
+{"abstract_id": "25208597", "label": "methods", "text": "The baseline single-photon emission computed tomography ( SPECT ) study was performed @ min after iv injection of @ MBq Tc-@m-HMPAO ( Ceretec ; GE Healthcare Ltd. .", "sentence_id": 3}
+{"abstract_id": "25208597", "label": "methods", "text": "Chalfont St. Giles , UK ) .", "sentence_id": 4}
+{"abstract_id": "25208597", "label": "methods", "text": "Fifteen randomized patients received a single dose of @ mg tadalafil in the morning , and a second SPECT study was performed @ h later .", "sentence_id": 5}
+{"abstract_id": "25208597", "label": "methods", "text": "Fifteen other patients received @ mg of tadalafil each morning for seven consecutive days , and the second SPECT study was performed @ h after the last dose .", "sentence_id": 6}
+{"abstract_id": "25208597", "label": "methods", "text": "The imaging data were evaluated using SPM software ( Wellcome Department of Cognitive Neurology , University College , London ) .", "sentence_id": 7}
+{"abstract_id": "25208597", "label": "results", "text": "Associations between any of the risk factors/comorbidities and the perfusion changes were not detected .", "sentence_id": 8}
+{"abstract_id": "25208597", "label": "results", "text": "All patients showed areas of reduced relative rCBF in the affected hemisphere after tadalafil administration compared to baseline ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25208597", "label": "results", "text": "No significant difference was found between patients on @ mg tadalafil and @ mg dose .", "sentence_id": 10}
+{"abstract_id": "25208597", "label": "conclusions", "text": "Tadalafil administration after cerebral stroke may be associated with diminished blood flow to areas adjacent to the stroke .", "sentence_id": 11}
+{"abstract_id": "25208597", "label": "conclusions", "text": "The alterations in perfusion suggest a need for caution in prescribing tadalafil to patients with a history of stroke , especially with continuous administration that may impose constant stress on the cerebral circulation .", "sentence_id": 12}
+{"abstract_id": "24732169", "label": "objective", "text": "To investigate the short-term effect of a mixed Kinesio taping ( KT ) model on range of ankle motion ( ROAM ) , gait , pain , perimeter of lower limbs , and quality of life in postmenopausal women with chronic venous insufficiency ( CVI ) .", "sentence_id": 0}
+{"abstract_id": "24732169", "label": "methods", "text": "Double-blinded , randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24732169", "label": "methods", "text": "Clinical setting .", "sentence_id": 2}
+{"abstract_id": "24732169", "label": "methods", "text": "Consecutive postmenopausal women ( N = @ ; mean age SD , @ y ) with mild CVI .", "sentence_id": 3}
+{"abstract_id": "24732169", "label": "methods", "text": "No participant withdrew because of adverse effects .", "sentence_id": 4}
+{"abstract_id": "24732169", "label": "methods", "text": "Participants were randomly assigned to either ( @ ) an experimental group to receive a mixed KT-compression treatment following KT recommendations for gastrocnemius muscle enhancement and functional correction of the ankle , and adding @ tapes to simulate traditional compression bandages ( no KT guidelines ) ; or ( @ ) a placebo control group for sham KT .", "sentence_id": 5}
+{"abstract_id": "24732169", "label": "methods", "text": "Both interventions were performed @ times a week during a @-week period .", "sentence_id": 6}
+{"abstract_id": "24732169", "label": "methods", "text": "ROAM , gait , pain , perimeter of right and left lower limb , and quality of life were assessed at baseline and @ hours posttreatment .", "sentence_id": 7}
+{"abstract_id": "24732169", "label": "results", "text": "Quality of life was better in the intervention group by a mean of @ points ( @ % confidence interval -LSB- CI -RSB- , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24732169", "label": "results", "text": "The experimental group also showed significant pre - / posttreatment improvements in both lower limbs in gait dorsiflexion ROAM ( @ % CI , @-@ @ ) , cadence ( @ % CI , @-@ @ ) , stride length ( @ % CI , @-@ @ ) , step length ( @ % CI , @-@ @ ) , stance phase ( @ % CI , @-@ ) , and foot ( @ % CI , @ -@ ) and malleolus ( @ % CI , @-@ @ ) circumference .", "sentence_id": 9}
+{"abstract_id": "24732169", "label": "results", "text": "None of these variables were significantly modified in the placebo group .", "sentence_id": 10}
+{"abstract_id": "24732169", "label": "results", "text": "Both groups reported a significant reduction in pain .", "sentence_id": 11}
+{"abstract_id": "24732169", "label": "conclusions", "text": "Ankle dorsiflexion during gait , walking parameters , peripheral edema , venous pain , and quality of life remain improved in patients with CVI at @ month after mixed KT-compression therapy .", "sentence_id": 12}
+{"abstract_id": "24732169", "label": "conclusions", "text": "KT may have a placebo effect on pain perception .", "sentence_id": 13}
+{"abstract_id": "24275909", "label": "objective", "text": "The authors compared psychoanalytic psychotherapy and cognitive-behavioral therapy ( CBT ) in the treatment of bulimia nervosa .", "sentence_id": 0}
+{"abstract_id": "24275909", "label": "methods", "text": "A randomized controlled trial was conducted in which @ patients with bulimia nervosa received either @ years of weekly psychoanalytic psychotherapy or @ sessions of CBT over @ months .", "sentence_id": 1}
+{"abstract_id": "24275909", "label": "methods", "text": "The main outcome measure was the Eating Disorder Examination interview , which was administered blind to treatment condition at baseline , after @ months , and after @ years .", "sentence_id": 2}
+{"abstract_id": "24275909", "label": "methods", "text": "The primary outcome analyses were conducted using logistic regression analysis .", "sentence_id": 3}
+{"abstract_id": "24275909", "label": "results", "text": "Both treatments resulted in improvement , but a marked difference was observed between CBT and psychoanalytic psychotherapy .", "sentence_id": 4}
+{"abstract_id": "24275909", "label": "results", "text": "After @ months , @ % of patients in CBT ( N = @ ) and @ % of patients in psychoanalytic psychotherapy ( N = @ ) had stopped binge eating and purging ( odds ratio = @ , @ % confidence interval -LSB- CI -RSB- = @-@ @ ; p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24275909", "label": "results", "text": "At @ years , @ % in the CBT group and @ % in the psychoanalytic psychotherapy group had stopped binge eating and purging ( odds ratio = @ , @ % CI = @-@ @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24275909", "label": "results", "text": "By the end of both treatments , substantial improvements in eating disorder features and general psychopathology were observed , but in general these changes took place more rapidly in CBT .", "sentence_id": 7}
+{"abstract_id": "24275909", "label": "conclusions", "text": "Despite the marked disparity in the number of treatment sessions and the duration of treatment , CBT was more effective in relieving binging and purging than psychoanalytic psychotherapy and was generally faster in alleviating eating disorder features and general psychopathology .", "sentence_id": 8}
+{"abstract_id": "24275909", "label": "conclusions", "text": "The findings indicate the need to develop and test a more structured and symptom-focused version of psychoanalytic psychotherapy for bulimia nervosa .", "sentence_id": 9}
+{"abstract_id": "25369857", "label": "background", "text": "Tobacco smoking prevalence continues to be high , particularly among adolescents and young adults with lower educational levels , and is therefore a serious public health problem .", "sentence_id": 0}
+{"abstract_id": "25369857", "label": "background", "text": "Tobacco smoking and problem drinking often co-occur and relapses after successful smoking cessation are often associated with alcohol use .", "sentence_id": 1}
+{"abstract_id": "25369857", "label": "background", "text": "This study aims at testing the efficacy of an integrated smoking cessation and alcohol intervention by comparing it to a smoking cessation only intervention for young people , delivered via the Internet and mobile phone .", "sentence_id": 2}
+{"abstract_id": "25369857", "label": "methods", "text": "A two-arm cluster-randomised controlled trial with one follow-up assessment after @months will be conducted .", "sentence_id": 3}
+{"abstract_id": "25369857", "label": "methods", "text": "Participants in the integrated intervention group will : ( @ ) receive individually tailored web-based feedback on their drinking behaviour based on age and gender norms , ( @ ) receive individually tailored mobile phone text messages to promote drinking within low-risk limits over a @-month period , ( @ ) receive individually tailored mobile phone text messages to support smoking cessation for @months , and ( @ ) be offered the option of registering for a more intensive program that provides strategies for smoking cessation centred around a self-defined quit date .", "sentence_id": 4}
+{"abstract_id": "25369857", "label": "methods", "text": "Participants in the smoking cessation only intervention group will only receive components ( @ ) and ( @ ) .", "sentence_id": 5}
+{"abstract_id": "25369857", "label": "methods", "text": "Study participants will be @ students who smoke tobacco daily/occasionally , from vocational schools in Switzerland .", "sentence_id": 6}
+{"abstract_id": "25369857", "label": "methods", "text": "Main outcome criteria are @-day point prevalence smoking abstinence and cigarette consumption assessed at the @-month follow up .", "sentence_id": 7}
+{"abstract_id": "25369857", "label": "conclusions", "text": "This is the first study testing a fully automated intervention for smoking cessation that simultaneously addresses alcohol use and interrelations between tobacco and alcohol use .", "sentence_id": 8}
+{"abstract_id": "25369857", "label": "conclusions", "text": "The integrated intervention can be easily implemented in various settings and could be used with large groups of young people in a cost-effective way .", "sentence_id": 9}
+{"abstract_id": "25217473", "label": "objective", "text": "To investigate the effect of intranasal ketamine versus alfentanil in addition to oral midazolam for the prevention of emergence agitation in children .", "sentence_id": 0}
+{"abstract_id": "25217473", "label": "methods", "text": "Children undergoing urological surgery with sevoflurane anaesthesia received oral midazolam @ min before induction and were then randomly assigned to receive @ mg/kg ketamine , @ g/kg alfentanil or @ ml isotonic saline intranasally .", "sentence_id": 1}
+{"abstract_id": "25217473", "label": "methods", "text": "Parental separation status and mask acceptance were assessed preoperatively .", "sentence_id": 2}
+{"abstract_id": "25217473", "label": "methods", "text": "Emergence agitation was evaluated using a paediatric anaesthesia emergence delirium ( PAED ) score .", "sentence_id": 3}
+{"abstract_id": "25217473", "label": "results", "text": "Data from @ children were evaluated in the study .", "sentence_id": 4}
+{"abstract_id": "25217473", "label": "results", "text": "There were no significant differences between the groups in demographic characteristics , recovery times or parental separation scores .", "sentence_id": 5}
+{"abstract_id": "25217473", "label": "results", "text": "Mask acceptance was significantly better in the ketamine group than in the saline group .", "sentence_id": 6}
+{"abstract_id": "25217473", "label": "results", "text": "The mean PAED score in the ketamine group was significantly better than in the other two groups , but was similar in the saline and alfentanil groups .", "sentence_id": 7}
+{"abstract_id": "25217473", "label": "results", "text": "The incidence of emergence agitation was @ % , @ % and @ % in the ketamine , alfentanil and saline groups , respectively .", "sentence_id": 8}
+{"abstract_id": "25217473", "label": "conclusions", "text": "The addition of intranasal ketamine to oral midazolam significantly improved the quality of induction and reduced sevoflurane-induced emergence agitation , in children undergoing urological surgery .", "sentence_id": 9}
+{"abstract_id": "26075372", "label": "objective", "text": "The aim of this study was to examine the effect of chitosan membrane on wound healing .", "sentence_id": 0}
+{"abstract_id": "26075372", "label": "methods", "text": "The effect of chitosan membranes was evaluated in an experimental rat model .", "sentence_id": 1}
+{"abstract_id": "26075372", "label": "methods", "text": "On day @ , circular full-thickness skin sections were excised from the scalps of rats .", "sentence_id": 2}
+{"abstract_id": "26075372", "label": "methods", "text": "The wounds were then measured and the surrounding area tattooed .", "sentence_id": 3}
+{"abstract_id": "26075372", "label": "methods", "text": "Rats were sacrificed either immediately after excision , or randomised into control and chitosan groups and followed up on day @ , @ , @ or @ .", "sentence_id": 4}
+{"abstract_id": "26075372", "label": "methods", "text": "Control group wounds were covered with Aquacel ( wound dressing ) .", "sentence_id": 5}
+{"abstract_id": "26075372", "label": "methods", "text": "Chitosan group wounds were covered with chitosan membranes and the wound dressing .", "sentence_id": 6}
+{"abstract_id": "26075372", "label": "methods", "text": "Wounds and the distances between the tattooed marks were measured on follow-up , the wound sites were harvested and histologically examined , and serum interleukin ( IL-@ ) levels were analysed .", "sentence_id": 7}
+{"abstract_id": "26075372", "label": "results", "text": "A total of @ rats were examined and all time points included @ control and @ chitosan treated animals , except for day @ which consisted of control animals only .", "sentence_id": 8}
+{"abstract_id": "26075372", "label": "results", "text": "On day @ , wounds in the chitosan group were significantly ( p < @ ) smaller ( @ % versus @ % of the original wound area ) than in the control group .", "sentence_id": 9}
+{"abstract_id": "26075372", "label": "results", "text": "Chitosan membranes were found to degrade at the wound sites between days @ and @ .", "sentence_id": 10}
+{"abstract_id": "26075372", "label": "results", "text": "Leukocyte counts were lower in the chitosan group than in the control group on day seven ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "26075372", "label": "results", "text": "IL-@ levels were significantly higher on day @ ( p < @ ) and @ ( p < @ ) in the chitosan group .", "sentence_id": 12}
+{"abstract_id": "26075372", "label": "conclusions", "text": "According to our results chitosan membrane may promote early wound healing , reduce inflammation and affect the IL-@ pathway , however , the membrane degrades at the wound site after day @ .", "sentence_id": 13}
+{"abstract_id": "25738669", "label": "background", "text": "The treatment of symptomatic congenital cytomegalovirus ( CMV ) disease with intravenous ganciclovir for @ weeks has been shown to improve audiologic outcomes at @ months , but the benefits wane over time .", "sentence_id": 0}
+{"abstract_id": "25738669", "label": "methods", "text": "We conducted a randomized , placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease , comparing @ months of therapy with @ weeks of therapy .", "sentence_id": 1}
+{"abstract_id": "25738669", "label": "methods", "text": "The primary end point was the change in hearing in the better ear ( `` best-ear '' hearing ) from baseline to @ months .", "sentence_id": 2}
+{"abstract_id": "25738669", "label": "methods", "text": "Secondary end points included the change in hearing from baseline to follow-up at @ and @ months and neurodevelopmental outcomes , with each end point adjusted for central nervous system involvement at baseline .", "sentence_id": 3}
+{"abstract_id": "25738669", "label": "results", "text": "A total of @ neonates underwent randomization , of whom @ had follow-up data at @ months that could be evaluated .", "sentence_id": 4}
+{"abstract_id": "25738669", "label": "results", "text": "Best-ear hearing at @ months was similar in the @-month group and the @-week group ( @ and @ participants , respectively , had improvement ; @ and @ had no change ; and @ and @ had worsening ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25738669", "label": "results", "text": "Total-ear hearing ( hearing in one or both ears that could be evaluated ) was more likely to be improved or to remain normal at @ months in the @-month group than in the @-week group ( @ % vs. @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25738669", "label": "results", "text": "The benefit in total-ear hearing was maintained at @ months ( @ % vs. @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25738669", "label": "results", "text": "At @ months , the @-month group , as compared with the @-week group , had better neurodevelopmental scores on the Bayley Scales of Infant and Toddler Development , third edition , on the language-composite component ( P = @ ) and on the receptive-communication scale ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25738669", "label": "results", "text": "Grade @ or @ neutropenia occurred in @ % of the participants during the first @ weeks .", "sentence_id": 9}
+{"abstract_id": "25738669", "label": "results", "text": "During the next @ months of the study , grade @ or @ neutropenia occurred in @ % of the participants in the @-month group and in @ % of those in the @-week group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25738669", "label": "conclusions", "text": "Treating symptomatic congenital CMV disease with valganciclovir for @ months , as compared with @ weeks , did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term .", "sentence_id": 11}
+{"abstract_id": "25738669", "label": "conclusions", "text": "( Funded by the National Institute of Allergy and Infectious Diseases ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 12}
+{"abstract_id": "24428097", "label": "objective", "text": "To compare the incidence and severity of emergence agitation , recovery profile , and adverse events between desflurane and sevoflurane anesthesia in unpremedicated pediatric ambulatory urologic surgery patients .", "sentence_id": 0}
+{"abstract_id": "24428097", "label": "methods", "text": "The study was conducted among @ healthy children , aged six months to nine years , and randomized to two groups , sevoflurane and desflurane , during maintenance anesthesia with laryngeal mask airway .", "sentence_id": 1}
+{"abstract_id": "24428097", "label": "methods", "text": "Recovery profile and perioperative adverse events were recorded .", "sentence_id": 2}
+{"abstract_id": "24428097", "label": "methods", "text": "The emergence agitation ( EA ) was assessed using a @-point scale by an anesthetist nurse in the recovery room who was blinded to the treatment .", "sentence_id": 3}
+{"abstract_id": "24428097", "label": "results", "text": "The incidences of EA between sevoflurane/desflurane were not significantly different at @ % / @ % , p = @ , and neither was the median ( IQR ) of severity ( @ ( @ , @ ) / @ ( @ , @ ) , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24428097", "label": "results", "text": "The awakening time in the desflurane group was @ + / - @ minutes , faster than in the sevoflurane group of @ + / - @ minutes ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24428097", "label": "results", "text": "The number of children having intraoperative respiratory events was significantly higher in the desflurane group ( @ ) , compared to the sevoflurane group ( @ ) ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24428097", "label": "conclusions", "text": "The occurrence of EA and adverse events between sevoflurane and desflurane were not different , except that the overall of intraoperative respiratory events was higher in desflurane group .", "sentence_id": 7}
+{"abstract_id": "24838844", "label": "background", "text": "Previous research suggests that African American smokers may have improved outcomes if interventions are culturally specific .", "sentence_id": 0}
+{"abstract_id": "24838844", "label": "background", "text": "However , few interventions sufficiently address the unique needs of this population in a format with large reach potential .", "sentence_id": 1}
+{"abstract_id": "24838844", "label": "background", "text": "The purpose of this study was to test the efficacy of a newly developed digital video disc ( DVD ) - based cessation intervention targeting African Americans .", "sentence_id": 2}
+{"abstract_id": "24838844", "label": "methods", "text": "In a @-arm randomized trial , smokers ( N = @ ) were randomly assigned to view either the new Pathways to Freedom ( PTF ) DVD or a standard control DVD .", "sentence_id": 3}
+{"abstract_id": "24838844", "label": "methods", "text": "Participants were assessed at baseline , immediately postviewing the DVD , and at a @-month follow-up .", "sentence_id": 4}
+{"abstract_id": "24838844", "label": "methods", "text": "The primary outcomes were feasibility and process variables , including intervention evaluations , readiness to quit , and risk perceptions , and smoking-related behavior changes were examined as secondary outcomes .", "sentence_id": 5}
+{"abstract_id": "24838844", "label": "results", "text": "Findings demonstrated the hypothesized positive effects of the PTF DVD compared with the control DVD on content evaluations , risk perceptions , and readiness to quit at follow-up .", "sentence_id": 6}
+{"abstract_id": "24838844", "label": "conclusions", "text": "We found initial evidence for the efficacy of the PTF DVD as a stand-alone intervention .", "sentence_id": 7}
+{"abstract_id": "24838844", "label": "conclusions", "text": "Future research will test the efficacy of the DVD for smoking cessation in a larger randomized trial .", "sentence_id": 8}
+{"abstract_id": "24838844", "label": "conclusions", "text": "The ultimate goal of this research is to validate a new intervention for an underserved community of smokers that can be used in multiple settings , such as community health clinics , primary care , quitlines , cessation clinics , and seminars/workshops .", "sentence_id": 9}
+{"abstract_id": "24582162", "label": "background", "text": "The aim of this multicenter study was to determine the normal ranges and the clinical relevance of multidirectional systolic parameters to evaluate global left ventricular ( LV ) systolic function .", "sentence_id": 0}
+{"abstract_id": "24582162", "label": "methods", "text": "Three hundred twenty-three healthy adult subjects prospectively included at @ centers and a cohort of @ patients with hypertension were analyzed .", "sentence_id": 1}
+{"abstract_id": "24582162", "label": "methods", "text": "Multidirectional global LV systolic function was analyzed using two-dimensional speckle-tracking echocardiography by means of two indices : longitudinal-circumferential systolic index ( the average of longitudinal and circumferential global systolic strain ) and global systolic index ( the average of longitudinal , circumferential , and radial global systolic strain ) .", "sentence_id": 2}
+{"abstract_id": "24582162", "label": "results", "text": "The ranges of values of the multidirectional systolic parameters in healthy subjects were -@ @ % for longitudinal-circumferential systolic index and @ @ % for global systolic index .", "sentence_id": 3}
+{"abstract_id": "24582162", "label": "results", "text": "In addition , the lowest expected values of these multidirectional indices were determined in this population ( calculated as -@ SDs from the mean ) : -@ % for longitudinal-circumferential systolic index and @ % for global systolic index .", "sentence_id": 4}
+{"abstract_id": "24582162", "label": "results", "text": "Concerning the clinical relevance of these measurements , these indices indicated the presence of subtle LV global systolic dysfunction in patients with hypertension , even though LV global longitudinal systolic strain and LV ejection fraction were normal .", "sentence_id": 5}
+{"abstract_id": "24582162", "label": "results", "text": "Moreover , in these patients , functional class ( dyspnea -LSB- New York Heart Association classification -RSB- ) was inversely related to both the longitudinal-circumferential index and the global systolic index .", "sentence_id": 6}
+{"abstract_id": "24582162", "label": "conclusions", "text": "In the present multicenter study analyzing a large cohort of healthy subjects and patients with hypertension , the normal range and the clinical relevance of multidirectional systolic parameters to evaluate global LV systolic function have been determined .", "sentence_id": 7}
+{"abstract_id": "24402825", "label": "methods", "text": "Curcumin revealed various health-beneficial properties in numerous studies .", "sentence_id": 0}
+{"abstract_id": "24402825", "label": "methods", "text": "However its bioavailability is low due to its limited intestinal uptake and rapid metabolism .", "sentence_id": 1}
+{"abstract_id": "24402825", "label": "methods", "text": "The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their safety as well as potential sex-differences .", "sentence_id": 2}
+{"abstract_id": "24402825", "label": "results", "text": "In this crossover study , healthy subjects ( @ women , @ men ) took , in random order , a single oral dose of @ mg curcuminoids as native powder , micronized powder , or liquid micelles .", "sentence_id": 3}
+{"abstract_id": "24402825", "label": "results", "text": "Blood and urine samples were collected for @ h and total curcuminoids and safety parameters were quantified .", "sentence_id": 4}
+{"abstract_id": "24402825", "label": "results", "text": "Based on the area under the plasma concentration-time curve ( AUC ) , the micronized curcumin was @ - , @ - , and @-fold and micellar curcumin @ - , @ - , and @-fold better bioavailable than native curcumin in women , men , and all subjects , respectively .", "sentence_id": 5}
+{"abstract_id": "24402825", "label": "results", "text": "Thus , women absorbed curcumin more efficiently than men .", "sentence_id": 6}
+{"abstract_id": "24402825", "label": "results", "text": "All safety parameters remained within the reference ranges following the consumption of all formulations .", "sentence_id": 7}
+{"abstract_id": "24402825", "label": "conclusions", "text": "Both , the micronized powder and in particular the liquid micellar formulation of curcumin significantly improved its oral bioavailability without altering safety parameters and may thus be ideally suited to deliver curcumin in human intervention trials .", "sentence_id": 8}
+{"abstract_id": "24402825", "label": "conclusions", "text": "The observed sex differences in curcumin absorption warrant further investigation .", "sentence_id": 9}
+{"abstract_id": "24583275", "label": "objective", "text": "Late adolescence represents a developmental risk period when many youth become involved in multiple forms of high-risk behaviors with adverse consequences .", "sentence_id": 0}
+{"abstract_id": "24583275", "label": "objective", "text": "This study assessed the degree to which two such behaviors , adolescent sexual behaviors and gambling , were associated in a community-based sample with a large African-American presence .", "sentence_id": 1}
+{"abstract_id": "24583275", "label": "methods", "text": "Data are derived from a cohort study .", "sentence_id": 2}
+{"abstract_id": "24583275", "label": "methods", "text": "This study focuses on @ African-American participants with complete information on gambling and sexual behaviors by age @ ( @ % of original cohort ) .", "sentence_id": 3}
+{"abstract_id": "24583275", "label": "methods", "text": "Gambling involvement and related problems were based on responses to the South Oaks Gambling Screen - Revised for Adolescents .", "sentence_id": 4}
+{"abstract_id": "24583275", "label": "methods", "text": "Several questions assessed sexual behaviors , including age of initiation .", "sentence_id": 5}
+{"abstract_id": "24583275", "label": "methods", "text": "Multivariable logistic regression models adjusted for demographics , intervention status , impulsivity , depressive and anxiety symptoms , and alcohol and illegal drug use .", "sentence_id": 6}
+{"abstract_id": "24583275", "label": "results", "text": "Almost half of the sample ( @ % , n = @ ) had gambled at least once before age @ .", "sentence_id": 7}
+{"abstract_id": "24583275", "label": "results", "text": "More gamblers than non-gamblers had initiated sexual intercourse by age @ ( aOR : @ -LSB- @ , @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "24583275", "label": "results", "text": "Among those who had initiated sexual activity , more gamblers than non-gamblers with high impulsivity levels at age @ ( vs. low impulsivity levels ) had become pregnant or had impregnated someone .", "sentence_id": 9}
+{"abstract_id": "24583275", "label": "results", "text": "Among those who had initiated sexual activity by age @ , more male gamblers had impregnated someone by age @ as compared to female gamblers becoming pregnant .", "sentence_id": 10}
+{"abstract_id": "24583275", "label": "conclusions", "text": "Gambling and sexual behaviors often co-occur among adolescents .", "sentence_id": 11}
+{"abstract_id": "24583275", "label": "conclusions", "text": "Such findings prompt the need for the inclusion of gambling , an often overlooked risky behavior , in behavioral prevention/intervention programs targeting adolescents .", "sentence_id": 12}
+{"abstract_id": "24463657", "label": "objective", "text": "Laparoscopic and robotic sacrocolpopexy are widely used for pelvic organ prolapse ( POP ) treatment .", "sentence_id": 0}
+{"abstract_id": "24463657", "label": "objective", "text": "Evidence comparing outcomes and costs is lacking .", "sentence_id": 1}
+{"abstract_id": "24463657", "label": "objective", "text": "We compared costs and clinically relevant outcomes in women randomized to laparoscopic sacrocolpopexy compared with robotic sacrocolpopexy .", "sentence_id": 2}
+{"abstract_id": "24463657", "label": "methods", "text": "Participants with symptomatic stage POP II or greater , including significant apical support loss , were randomized to either laparoscopic or robotic sacrocolpopexy .", "sentence_id": 3}
+{"abstract_id": "24463657", "label": "methods", "text": "We compared surgical costs ( including costs for robot , initial hospitalization ) and rehospitalization within @ weeks .", "sentence_id": 4}
+{"abstract_id": "24463657", "label": "methods", "text": "Secondary outcomes included postoperative pain , POP quantification , symptom severity and quality of life , and adverse events .", "sentence_id": 5}
+{"abstract_id": "24463657", "label": "results", "text": "We randomized @ women ( mean age @ years ) : laparoscopic ( n = @ ) and robotic ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24463657", "label": "results", "text": "The robotic sacrocolpopexy group had higher initial hospital costs ( $ @,@ compared with $ @,@ , P < @ ) and over @ weeks , hospital costs remained higher for robotic sacrocolpopexy ( $ @,@ compared with $ @,@ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24463657", "label": "results", "text": "When we excluded costs of robot purchase and maintenance , we did not detect a statistical difference in initial day of surgery costs of robotic compared with laparoscopic ( $ @,@ compared with $ @,@ ; P = @ ) or hospital costs over @ weeks ( $ @,@ compared with $ @,@ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24463657", "label": "results", "text": "The robotic group had longer operating room times ( @ minutes compared with @ minutes , P = @ ) and higher pain scores @ week after surgery ( @ compared with @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24463657", "label": "results", "text": "There were no group differences in symptom bother by Pelvic Floor Distress Inventory , POP stage , or rate of adverse events .", "sentence_id": 10}
+{"abstract_id": "24463657", "label": "conclusions", "text": "Costs of robotic sacrocolpopexy are higher than laparoscopic , whereas short-term outcomes and complications are similar .", "sentence_id": 11}
+{"abstract_id": "24463657", "label": "conclusions", "text": "Primary cost differences resulted from robot maintenance and purchase costs .", "sentence_id": 12}
+{"abstract_id": "25046547", "label": "background", "text": "Proton pump inhibitor ( PPI ) increases the risk of decrease in bone mineral density ( BMD ) .", "sentence_id": 0}
+{"abstract_id": "25046547", "label": "background", "text": "However , whether calcitrol improves this situation is unknown .", "sentence_id": 1}
+{"abstract_id": "25046547", "label": "objective", "text": "The current study investigates the effects of calcitriol on BMD in patients with esomeprazole therapy .", "sentence_id": 2}
+{"abstract_id": "25046547", "label": "methods", "text": "Three hundred and eighty-six participants with gastrointestinal ulcerations were enrolled and randomly assigned into controlled and supplemented groups .", "sentence_id": 3}
+{"abstract_id": "25046547", "label": "methods", "text": "Participants in the controlled group were prescribed esomeprazole ( @mg/qd ) , while the supplemented group was prescribed esomeprazole ( @mg/qd ) and calcitriol ( @ g/qd ) .", "sentence_id": 4}
+{"abstract_id": "25046547", "label": "methods", "text": "BMD , serum levels of calcium , carboxy-terminal collagen crosslinks ( CTX ) , and alkaline-phosphatase ( ALP ) were assessed .", "sentence_id": 5}
+{"abstract_id": "25046547", "label": "results", "text": "( @ ) No significant between-group difference of age , gender , smoking , previous glucocorticoid use and hemoglobin level was found ; ( @ ) after @ d of PPI therapy , BMD T score in the controlled group was slightly increased compared with initial ( -@ versus -@ , p = @ ) , while there was no change in the supplemented group ( -@ versus -@ , p = @ ) ; ( @ ) during study termination , calcium level in the supplemented group was slightly higher than the controlled group ( @ mmol/L versus @ mmol/L , p = @ ) , while no significant differences of CTX ( @ pg/mL versus @ pg/mL , p = @ ) and ALP were found among these two groups ( @ U/L versus @ U/L , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25046547", "label": "conclusions", "text": "Patients with gastrointestinal ulcerations with esomeprazole therapy , calcitriol supplement showed no efficacy on BMD changes .", "sentence_id": 7}
+{"abstract_id": "24814528", "label": "background", "text": "Polycystic ovary syndrome ( PCOS ) is the most common endocrine cause of menstrual irregularities , hirsutism and acne .", "sentence_id": 0}
+{"abstract_id": "24814528", "label": "background", "text": "Women with PCOS present elevated plasma insulin levels , both fasting and after a glucose load , as an indirect evidence of insulin resistance .", "sentence_id": 1}
+{"abstract_id": "24814528", "label": "background", "text": "PCOS women may also present hypertension , low levels of HDL cholesterol , hypertriglyceridemia , visceral obesity and a higher level of CRP and fibrinogen that can predict an atherosclerotic risk .", "sentence_id": 2}
+{"abstract_id": "24814528", "label": "methods", "text": "This study was carried out on @ young women with PCOS selected according to the @ diagnostic criteria of The Rotterdam Consensus Statement and @ Control women .", "sentence_id": 3}
+{"abstract_id": "24814528", "label": "methods", "text": "PCOS women were treated with pioglitazone @ mg/day and at the beginning and after @ months of treatment were evaluated : menstrual cycle trend , hirsutism and acne , total cholesterolemia and HDL , triglyceridemia , fibrinogenemia , C-reactive protein , oral glucose tolerance test , glycated hemoglobin , FSH , LH , @OH-progesterone , @-estradiol , free and total testosterone , SHBG , DHEA-S , @-androstenedione and adiponectin .", "sentence_id": 4}
+{"abstract_id": "24814528", "label": "conclusions", "text": "Treatment with pioglitazone improves the irregularities of menses and hirsutism .", "sentence_id": 5}
+{"abstract_id": "24814528", "label": "conclusions", "text": "Six months of treatment modify other parameters linked with a higher risk of type @ diabetes mellitus and cardiovascular diseases : adiponectin increased with reduction of insulin resistance while fibrinogen and CRP levels decreased .", "sentence_id": 6}
+{"abstract_id": "25864242", "label": "objective", "text": "To determine the efficacy in reducing dentin hypersensitivity ( DHS ) of a combined in-office and home-use desensitizing system , each product containing @ % arginine and calcium carbonate ( Test ) , following a dental scaling procedure , compared to the combination of a conventional prophylactic paste and a potassium nitrate dentifrice ( Control ) , in a group of patients with known dentin hypersensitivity .", "sentence_id": 0}
+{"abstract_id": "25864242", "label": "methods", "text": "An @-week clinical study , with @ subjects , was conducted in Piracicaba , So Paulo , Brazil , using a double-blind/two treatment design .", "sentence_id": 1}
+{"abstract_id": "25864242", "label": "methods", "text": "Air blast sensitivity assessments were used to compare the efficacy of the two approaches using both the Schiff scale as well as a Visual Analogue Scale ( VAS ) .", "sentence_id": 2}
+{"abstract_id": "25864242", "label": "results", "text": "Immediately after prophylaxis , the Test treatment provided significant reduction in DHS when compared to baseline values ( VAS = @ % and Schiff = @ % ) , while for Control treatment this difference was not statistically significant ( VAS = @ % and Schiff = @ % ) .", "sentence_id": 3}
+{"abstract_id": "25864242", "label": "results", "text": "The comparison between groups after prophylaxis showed a greater DHS reduction for the Test treatment ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25864242", "label": "results", "text": "The reductions in DHS after @ , @ and @ weeks were significant for both groups , however , when considering Schiff scale , the Test treatment provided greater DHS reduction after @ weeks ( @ % for Test versus @ % for Control ) and @ weeks ( @ % for Test and @ % for Control ) , while after @ weeks there was no significant difference between groups ( @ % for Test versus @ % for Control ) .", "sentence_id": 5}
+{"abstract_id": "26390793", "label": "objective", "text": "To compare vision quality following phacoemulsification cataract extraction and implantation of a Big Bag or Akreos Adapt intraocular lens ( IOL ) in patients diagnosed with high myopia complicated with cataract .", "sentence_id": 0}
+{"abstract_id": "26390793", "label": "methods", "text": "This was a randomized prospective control study .", "sentence_id": 1}
+{"abstract_id": "26390793", "label": "methods", "text": "The patients with high myopia .", "sentence_id": 2}
+{"abstract_id": "26390793", "label": "methods", "text": "complicated with cataract , with axial length @ mm , and corneal astigmatism @D were enrolled and randomly divided into the Big Bag and Akreos Adapt IOL groups .", "sentence_id": 3}
+{"abstract_id": "26390793", "label": "methods", "text": "All patients underwent phacoemulsification cataract extraction and lens implantation .", "sentence_id": 4}
+{"abstract_id": "26390793", "label": "methods", "text": "At @ months after surgery , intraocular high-order aberration was measured by a Tracey-iTrace wavefront aberrometer at a pupil diameter of @ mm in an absolutely dark room and statistically compared between two groups .", "sentence_id": 5}
+{"abstract_id": "26390793", "label": "methods", "text": "The images of the anterior segment of eyes were photographed with a Scheimpflug camera using Penta-cam three-dimensional anterior segment analyzer .", "sentence_id": 6}
+{"abstract_id": "26390793", "label": "methods", "text": "The tilt and decentration of the IOL were calculated by Image-pro plus @ imaging analysis software and statistically compared between two groups .", "sentence_id": 7}
+{"abstract_id": "26390793", "label": "results", "text": "In total , @ patients ( @ eyes ) , including @ males and @ females , were enrolled in this study .", "sentence_id": 8}
+{"abstract_id": "26390793", "label": "results", "text": "The total high-order aberration and coma in the Akreos Adapt group ( @ eyes ) were significantly higher compared with those in the Big Bag ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "26390793", "label": "results", "text": "The clover and spherical aberration did not differ between the two groups ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "26390793", "label": "results", "text": "The horizontal and vertical decentration were significantly smaller in the Big Bag lens group than in the Akreos Adapt group ( both P < @ ) , whereas the tilt of IOL did not significantly differ between the two groups ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "26390793", "label": "conclusions", "text": "Both Big Bag and Akreos Adapt IOLs possess relatively good intraocular stability implanted in patients with high myopia .", "sentence_id": 12}
+{"abstract_id": "26390793", "label": "conclusions", "text": "Compared with the Akreos Adapt IOL , the Big Bag IOL presents with smaller intraocular high-order aberration .", "sentence_id": 13}
+{"abstract_id": "26390793", "label": "conclusions", "text": "Coma is the major difference between the two groups .", "sentence_id": 14}
+{"abstract_id": "25157767", "label": "background", "text": "We hypothesized that the combination of bevacizumab , carboplatin , and pemetrexed will be an effective first-line regimen in fit , elderly patients with nonsquamous non-small-cell lung cancer .", "sentence_id": 0}
+{"abstract_id": "25157767", "label": "methods", "text": "Treatment-nave , stage IIIB/IV nonsquamous non-small-cell lung cancer patients more than @ years old with good performance status ( Eastern Cooperative Oncology Group performance status @-@ ) and adequate organ function were eligible .", "sentence_id": 1}
+{"abstract_id": "25157767", "label": "methods", "text": "Carboplatin area under the curve @ , pemetrexed @ mg/m , and bevacizumab @ mg/kg were administered on day @ of each @-day cycle ( up to six cycles ) followed by maintenance pemetrexed and bevacizumab .", "sentence_id": 2}
+{"abstract_id": "25157767", "label": "methods", "text": "The primary end point of @-month progression-free survival rate of at least @ % was assessed using a one-stage binomial design .", "sentence_id": 3}
+{"abstract_id": "25157767", "label": "methods", "text": "Quality of life ( QOL ) questionnaires were administered .", "sentence_id": 4}
+{"abstract_id": "25157767", "label": "methods", "text": "Polymorphisms in genes encoding relevant proteins ( drug targets , transport , and metabolism proteins ) were correlated with treatment outcome .", "sentence_id": 5}
+{"abstract_id": "25157767", "label": "results", "text": "Fifty-seven eligible patients were enrolled .", "sentence_id": 6}
+{"abstract_id": "25157767", "label": "results", "text": "Median age was @ years .", "sentence_id": 7}
+{"abstract_id": "25157767", "label": "results", "text": "Median treatment cycles received was @ .", "sentence_id": 8}
+{"abstract_id": "25157767", "label": "results", "text": "The most common grade @ or higher non-hematologic adverse events were fatigue ( @ % ) and hypertension ( @ % ) ; @ % had grade @ neutropenia and @ % had grade @ thrombocytopenia .", "sentence_id": 9}
+{"abstract_id": "25157767", "label": "results", "text": "Three patients experienced grade @/@ hemorrhagic events ( one pulmonary , two gastrointestinal ) .", "sentence_id": 10}
+{"abstract_id": "25157767", "label": "results", "text": "Primary end point of PFS@ was @ % ( @ % confidence interval -LSB- CI -RSB- : @-@ % ) .", "sentence_id": 11}
+{"abstract_id": "25157767", "label": "results", "text": "Median PFS was @ months ( @ % CI : @-@ @ ) , median overall survival was @ months ( @ % CI : @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "25157767", "label": "results", "text": "Polymorphic KDR and VEGFA variants correlated with survival and toxicity , respectively .", "sentence_id": 13}
+{"abstract_id": "25157767", "label": "results", "text": "There was no significant change in overall QOL scores over time .", "sentence_id": 14}
+{"abstract_id": "25157767", "label": "conclusions", "text": "This regimen is feasible and did not decrease the QOL in this study population .", "sentence_id": 15}
+{"abstract_id": "25157767", "label": "conclusions", "text": "However , it did not meet the primary efficacy end point .", "sentence_id": 16}
+{"abstract_id": "24848178", "label": "objective", "text": "The aim of this study was to evaluate patient satisfaction and cost in spinal and general anesthesia for lumbar disc surgery .", "sentence_id": 0}
+{"abstract_id": "24848178", "label": "methods", "text": "The study was performed on @ ASA class I-II patients with one level lumbar disc herniation ( LDH ) .", "sentence_id": 1}
+{"abstract_id": "24848178", "label": "methods", "text": "In this prospective study , patients were assigned randomly to either spinal anesthesia or general anesthesia groups .", "sentence_id": 2}
+{"abstract_id": "24848178", "label": "methods", "text": "Hemodynamic variables , intraoperative opioid requirements , postoperative pain scores and analgesic requirements and complications were recorded .", "sentence_id": 3}
+{"abstract_id": "24848178", "label": "methods", "text": "Patients were handed a questionnaire about the procedure they underwent to determine patient satisfaction .", "sentence_id": 4}
+{"abstract_id": "24848178", "label": "methods", "text": "The costs of preoperative and postoperative anesthesia procedures , medications , and hospitalization were calculated individually .", "sentence_id": 5}
+{"abstract_id": "24848178", "label": "results", "text": "Spinal anesthesia and general anesthesia were similar concerning hemodynamic stability , first urination time , first mobilization time , postoperative analgesic requirement , and pain .", "sentence_id": 6}
+{"abstract_id": "24848178", "label": "results", "text": "Patients in group S needed less additional dose of fentanyl intraoperatively than the patients in group G. Patient satisfaction was significantly higher in Group S when compared to Group G. Total cost was higher in Group G compared to Group S.", "sentence_id": 7}
+{"abstract_id": "24848178", "label": "conclusions", "text": "We conclude that successful LDH surgery can be performed using either anesthesia type .", "sentence_id": 8}
+{"abstract_id": "24848178", "label": "conclusions", "text": "As long as patients are selected carefully , spinal anesthesia is a safe , comfortable , and a more economical alternative .", "sentence_id": 9}
+{"abstract_id": "24707676", "label": "objective", "text": "This study aims to determine the difference between transcervical resection of septum ( TCRS ) and transcervical incision of septum ( TCIS ) in the improvement of reproductive prognosis .", "sentence_id": 0}
+{"abstract_id": "24707676", "label": "methods", "text": "Women with uterine septum in the Affiliated Hospital of Ningxia Medical University were retrospectively analyzed .", "sentence_id": 1}
+{"abstract_id": "24707676", "label": "methods", "text": "A statistical method was used according to operative time , postoperative menstruation , postoperative pregnancy rate , postoperative term delivery rate , and so on .", "sentence_id": 2}
+{"abstract_id": "24707676", "label": "results", "text": "Compared with TCRS , the TCIS method decreased operative time , blood loss , and consumption of uterus distension medium .", "sentence_id": 3}
+{"abstract_id": "24707676", "label": "results", "text": "No statistical difference was observed in operative complications between the two methods .", "sentence_id": 4}
+{"abstract_id": "24707676", "label": "results", "text": "After TCIS , the incidence of uterine adhesion was low and the degree of endometrial epithelialisation was high by hysteroscopy review .", "sentence_id": 5}
+{"abstract_id": "24707676", "label": "results", "text": "No statistical difference was observed in residual septum after the operation .", "sentence_id": 6}
+{"abstract_id": "24707676", "label": "results", "text": "The total pregnancy rate after TCIS was higher than that of TCRS .", "sentence_id": 7}
+{"abstract_id": "24707676", "label": "results", "text": "However , no statistical difference was observed in early and late pregnancy loss rates , preterm birth rate , and term birth rate .", "sentence_id": 8}
+{"abstract_id": "24707676", "label": "conclusions", "text": "TCIS exhibits advantages of decreasing operative time , blood loss , and consumption of uterus distension medium .", "sentence_id": 9}
+{"abstract_id": "24707676", "label": "conclusions", "text": "TCIS can reduce the incidence of uterine adhesion and can promote endometrial epithelialisation , which are the key factors to increase pregnancy rate after operation .", "sentence_id": 10}
+{"abstract_id": "25017001", "label": "objective", "text": "Major depressive disorder has been linked with inflammatory processes , but it is unclear whether individual differences in levels of inflammatory biomarkers could help match patients to treatments that are most likely to be beneficial .", "sentence_id": 0}
+{"abstract_id": "25017001", "label": "objective", "text": "The authors tested the hypothesis that C-reactive protein ( CRP ) , a commonly available marker of systemic inflammation , predicts differential response to escitalopram ( a serotonin reuptake inhibitor ) and nortriptyline ( a norepinephrine reuptake inhibitor ) .", "sentence_id": 1}
+{"abstract_id": "25017001", "label": "methods", "text": "The hypothesis was tested in the Genome-Based Therapeutic Drugs for Depression ( GENDEP ) study , a multicenter open-label randomized clinical trial .", "sentence_id": 2}
+{"abstract_id": "25017001", "label": "methods", "text": "CRP was measured with a high-sensitivity method in serum samples from @ adult men and women with major depressive disorder randomly allocated to @-week treatment with escitalopram ( N = @ ) or nortriptyline ( N = @ ) .", "sentence_id": 3}
+{"abstract_id": "25017001", "label": "methods", "text": "The primary outcome measure was the score on the Montgomery-sberg Depression Rating Scale ( MADRS ) , administered weekly .", "sentence_id": 4}
+{"abstract_id": "25017001", "label": "results", "text": "CRP level at baseline differentially predicted treatment outcome with the two antidepressants ( CRP-drug interaction : = @ , @ % CI = @ , @ ) .", "sentence_id": 5}
+{"abstract_id": "25017001", "label": "results", "text": "For patients with low levels of CRP ( < @ mg/L ) , improvement on the MADRS score was @ points higher with escitalopram than with nortriptyline .", "sentence_id": 6}
+{"abstract_id": "25017001", "label": "results", "text": "For patients with higher CRP levels , improvement on the MADRS score was @ points higher with nortriptyline than with escitalopram .", "sentence_id": 7}
+{"abstract_id": "25017001", "label": "results", "text": "CRP and its interaction with medication explained more than @ % of individual-level variance in treatment outcome .", "sentence_id": 8}
+{"abstract_id": "25017001", "label": "conclusions", "text": "An easily accessible peripheral blood biomarker may contribute to improvement in outcomes of major depressive disorder by personalizing treatment choice .", "sentence_id": 9}
+{"abstract_id": "25636135", "label": "objective", "text": "Chronic tension-type headache ( CTTH ) is a chronic syndrome characterized by frequent headache occurring more than @ days per month .", "sentence_id": 0}
+{"abstract_id": "25636135", "label": "objective", "text": "The intensity and duration of headache pain can be very distressing and disabling on an individuals ' well-being .", "sentence_id": 1}
+{"abstract_id": "25636135", "label": "objective", "text": "The purpose of this study was to examine the applicability of sauna bathing as a new method of treatment for reducing pain in patients with CTTH .", "sentence_id": 2}
+{"abstract_id": "25636135", "label": "methods", "text": "Thirty-seven people who fulfilled the International Headache Society criteria for CTTH were randomly assigned into two groups .", "sentence_id": 3}
+{"abstract_id": "25636135", "label": "methods", "text": "The control group ( n = @ ) received advice and education while the intervention group ( n = @ ) received the same advice and attended a sauna regularly for @ weeks .", "sentence_id": 4}
+{"abstract_id": "25636135", "label": "methods", "text": "Reductions in subjective pain were determined using the numerical pain rating scale ( NPRS ) .", "sentence_id": 5}
+{"abstract_id": "25636135", "label": "methods", "text": "Disturbance in sleep , depression as assessed by Beckman Disability Index ( BDI ) , and Headache Disability Index ( HDI ) were measured .", "sentence_id": 6}
+{"abstract_id": "25636135", "label": "results", "text": "Mean change in headache intensity significantly differed between the sauna and control group by @ ( @ % confidence interval , @-@ @ ; F = @ ; df = @ , @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25636135", "label": "results", "text": "There was no statistically significant change in duration of headache or improvement in sleep , depression , or HDI between the sauna and control groups .", "sentence_id": 8}
+{"abstract_id": "25636135", "label": "conclusions", "text": "Regular sauna bathing is a simple , self-directed treatment that is effective for reducing headache pain intensity in CTTH .", "sentence_id": 9}
+{"abstract_id": "25103781", "label": "background", "text": "Alpha adrenergic drugs are usually used in the treatment of erectile and ejaculatory dysfunction in humans .", "sentence_id": 0}
+{"abstract_id": "25103781", "label": "background", "text": "The influence of such drugs on the seminal characteristics of wild animals has not been verified ; whereas their impact on the seminal characteristics and erectile and ejaculatory functions of collared peccaries ( Tayassu tajacu ) has already been determined .", "sentence_id": 1}
+{"abstract_id": "25103781", "label": "background", "text": "This study aimed at investigating and comparing the effects of medetomidine and atipamezole on the seminal variables of collared peccaries undergoing electroejaculation as well as at determining whether these drugs affected the erectile and ejaculatory functions of this species .", "sentence_id": 2}
+{"abstract_id": "25103781", "label": "results", "text": "A statistically significant difference in sperm concentration was observed between AP ( @ @ @ sperm/ml ) and MP ( @ @ @ sperm/ml ) ; however , both these treatments did not differ from P treatment ( @ @ @ sperm/ml ) .", "sentence_id": 3}
+{"abstract_id": "25103781", "label": "results", "text": "No statistically significant difference was observed among all treatments with regard to erectile function .", "sentence_id": 4}
+{"abstract_id": "25103781", "label": "results", "text": "With regard to ejaculation time , no significant difference was observed between the MP and AP treatments ; however , when compared with the P treatment , AP exhibited a significantly higher difference .", "sentence_id": 5}
+{"abstract_id": "25103781", "label": "conclusions", "text": "When collared peccaries were anesthetized with propofol , neither medetomidine nor atipamezole significantly affected the characteristics of the semen or the erectile function , despite the fact that the AP treatment increased ejaculation time .", "sentence_id": 6}
+{"abstract_id": "25103781", "label": "conclusions", "text": "Therefore , the data indicate that using propofol alone is an effective anesthetic protocol for collecting semen in collared peccaries .", "sentence_id": 7}
+{"abstract_id": "25103781", "label": "conclusions", "text": "Other non-injectable anesthetic drugs , such as inhaled anesthetics , may be used in future research to collect semen from peccaries .", "sentence_id": 8}
+{"abstract_id": "24256139", "label": "background", "text": "The currently proven time window for thrombolysis in ischemic stroke is @ h. Beyond this , the risks and benefits of thrombolysis are uncertain .", "sentence_id": 0}
+{"abstract_id": "24256139", "label": "objective", "text": "To determine whether thrombolysis and reperfusion were beneficial after @ h , we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within @-@h , using data from the Echoplanar Imaging Thrombolytic Evaluation Trial .", "sentence_id": 1}
+{"abstract_id": "24256139", "label": "methods", "text": "In the Echoplanar Imaging Thrombolytic Evaluation Trial , ischemic stroke patients presenting three to six-hours after stroke onset were randomized to tissue plasminogen activator or placebo , without knowledge of magnetic resonance imaging results .", "sentence_id": 2}
+{"abstract_id": "24256139", "label": "methods", "text": "This analysis was restricted to patients treated between @ and @h .", "sentence_id": 3}
+{"abstract_id": "24256139", "label": "methods", "text": "The effect of tissue plasminogen activator and reperfusion on infarct growth between baseline diffusion-weighted imaging and day @ T@ imaging was assessed , along with good neurological outcome ( @ point reduction or reaching @-@ at @ days on National Institutes of Health Stroke Scale ) and functional outcome ( modified Rankin scale ) .", "sentence_id": 4}
+{"abstract_id": "24256139", "label": "methods", "text": "The effect of tissue plasminogen activator on reperfusion was also analyzed .", "sentence_id": 5}
+{"abstract_id": "24256139", "label": "results", "text": "Sixty-nine patients were treated @-@h after onset , and infarct growth was assessed in @ .", "sentence_id": 6}
+{"abstract_id": "24256139", "label": "results", "text": "Tissue plasminogen activator was associated with lower relative growth ( @ % vs. @ % , P = @ ) and a trend to lower absolute growth ( -@ ml versus @ ml , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24256139", "label": "results", "text": "Reperfusion was increased in the tissue plasminogen activator group ( @ % versus @ % , P = @ ) and was associated with increased rates of good neurological ( @ % versus @ % P < @ ) and functional ( modified Rankin scale @-@ @ % versus @ % , P = @ ) outcomes .", "sentence_id": 8}
+{"abstract_id": "24256139", "label": "results", "text": "Reperfusion was strongly associated with lower relative ( @ % versus @ % , P < @ ) and absolute ( -@ ml versus @ml , P < @ ) infarct growth .", "sentence_id": 9}
+{"abstract_id": "24256139", "label": "conclusions", "text": "Thrombolysis @-@h after stroke onset reduced infarct growth and increased the rate of reperfusion , which was associated with good neurological and functional outcome .", "sentence_id": 10}
+{"abstract_id": "25109511", "label": "background", "text": "Tianeptine is widely used for controlling depressive symptoms .", "sentence_id": 0}
+{"abstract_id": "25109511", "label": "objective", "text": "The aim of this study was to evaluate the bioequivalence between the generic ( test ) formulation containing tianeptine sodium @ mg and the branded ( reference ) formulation Stablon with regard to their pharmacokinetic profiles .", "sentence_id": 1}
+{"abstract_id": "25109511", "label": "methods", "text": "A randomized , two-sequence , two-treatment crossover study was conducted in healthy male Korean volunteers .", "sentence_id": 2}
+{"abstract_id": "25109511", "label": "methods", "text": "All of the enrolled subjects were allocated to one of two sequence groups .", "sentence_id": 3}
+{"abstract_id": "25109511", "label": "methods", "text": "They were administered a tablet of the test or reference formulation and then administered the alternative formulation after a @-day washout period .", "sentence_id": 4}
+{"abstract_id": "25109511", "label": "methods", "text": "The blood samples were taken before dosing and at @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , and @ hours after dosing .", "sentence_id": 5}
+{"abstract_id": "25109511", "label": "methods", "text": "The plasma concentrations of tianeptine were analyzed using high-performance liquid chromatography with tandem mass spectrometer .", "sentence_id": 6}
+{"abstract_id": "25109511", "label": "methods", "text": "Tolerability was assessed throughout the study .", "sentence_id": 7}
+{"abstract_id": "25109511", "label": "results", "text": "The pharmacokinetic parameters were assessed in the @ subjects who completed the study .", "sentence_id": 8}
+{"abstract_id": "25109511", "label": "results", "text": "The tianeptine C ( max ) for the test formulation was @ @ ng/mL ( mean SD ) and that for the reference formulation was @ @ ng/mL .", "sentence_id": 9}
+{"abstract_id": "25109511", "label": "results", "text": "The AUC ( last ) of tianeptine was @ @ ngh/mL for the test formulation and @ @ ngh/mL for the reference formulation .", "sentence_id": 10}
+{"abstract_id": "25109511", "label": "results", "text": "The geometric mean ratio ( % ) of the test to reference formulation was @ ( @ % CI , @ - @ ) for C ( max ) and @ ( @ - @ ) for AUC ( last ) .", "sentence_id": 11}
+{"abstract_id": "25109511", "label": "results", "text": "Clinically significant adverse events were not reported during the study .", "sentence_id": 12}
+{"abstract_id": "25109511", "label": "conclusions", "text": "The test and reference formulations of tianeptine were bioequivalent with regard to the pharmacokinetic parameters of Cmax and AUC ( last ) .", "sentence_id": 13}
+{"abstract_id": "25109511", "label": "conclusions", "text": "Both formulations were tolerated by all of the participants .", "sentence_id": 14}
+{"abstract_id": "24581050", "label": "background", "text": "Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency , which has developed to synchronous mass activity owing the lack of inhibition .", "sentence_id": 0}
+{"abstract_id": "24581050", "label": "background", "text": "We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize around tonotopic regions coding the tinnitus frequency .", "sentence_id": 1}
+{"abstract_id": "24581050", "label": "background", "text": "Based on this assumption a novel treatment for tonal tinnitus - tailor-made notched music training ( TMNMT ) ( Proc Natl Acad Sci USA @:@ -@ , @ ; Ann N Y Acad Sci @:@ -@ , @ ; Frontiers Syst Neurosci @:@ , @ ) has been introduced and will be tested in this clinical trial on a large number of tinnitus patients .", "sentence_id": 2}
+{"abstract_id": "24581050", "label": "methods", "text": "A randomized controlled trial ( RCT ) in parallel group design will be performed in a double-blinded manner .", "sentence_id": 3}
+{"abstract_id": "24581050", "label": "methods", "text": "The choice of the intervention we are going to apply is based on two `` proof of concept '' studies in humans ( Proc Natl Acad Sci USA @:@ -@ , @ ; Ann N Y Acad Sci @:@ -@ , @ ; Frontiers Syst Neurosci @:@ , @ ; PloS One @ ( @ ) : e@ , @ ) and on a recent animal study ( Front Syst Neurosci @:@ , @ ) .", "sentence_id": 4}
+{"abstract_id": "24581050", "label": "methods", "text": "The RCT includes @ participants with chronic , tonal tinnitus who listened to tailor-made notched music ( TMNM ) for two hours a day for three months .", "sentence_id": 5}
+{"abstract_id": "24581050", "label": "methods", "text": "The effect of TMNMT is assessed by the tinnitus handicap questionnaire and visual analogue scales ( VAS ) measuring perceived tinnitus loudness , distress and handicap .", "sentence_id": 6}
+{"abstract_id": "24581050", "label": "conclusions", "text": "This is the first randomized controlled trial applying TMNMT on a larger number of patients with tonal tinnitus .", "sentence_id": 7}
+{"abstract_id": "24581050", "label": "conclusions", "text": "Our data will verify more securely and reliably the effectiveness of this kind of completely non-invasive and low-cost treatment approach on tonal tinnitus .", "sentence_id": 8}
+{"abstract_id": "24754529", "label": "background", "text": "Actinic damage is responsible for the development of multiple , recurrent non-melanoma skin cancers ( NMSCs ) , including actinic keratoses ( AKs ) .", "sentence_id": 0}
+{"abstract_id": "24754529", "label": "background", "text": "Photodynamic therapy ( PDT ) and imiquimod cream ( IMIQ ) @ % are recommended as field-directed treatment options .", "sentence_id": 1}
+{"abstract_id": "24754529", "label": "objective", "text": "To compare efficacy and safety of methyl aminolevulinate ( MAL ) - PDT vs. IMIQ @ % in the prevention of new NMSCs development patients with field changes .", "sentence_id": 2}
+{"abstract_id": "24754529", "label": "methods", "text": "Patients with field cancerization of the face or scalp were randomized to receive MAL-PDT on one side , and IMIQ @ % on the mirror field .", "sentence_id": 3}
+{"abstract_id": "24754529", "label": "methods", "text": "The primary endpoint was the number of new lesions on the treated fields during a @-month follow-up period .", "sentence_id": 4}
+{"abstract_id": "24754529", "label": "methods", "text": "Secondary assessments included adverse events and patient preference .", "sentence_id": 5}
+{"abstract_id": "24754529", "label": "results", "text": "Forty-four patients completed the study .", "sentence_id": 6}
+{"abstract_id": "24754529", "label": "results", "text": "MAL-PDT and IMIQ did not differ concerning the primary endpoint , as there was no statistically significant difference in terms of development of new NMSCs at any point of follow-up .", "sentence_id": 7}
+{"abstract_id": "24754529", "label": "results", "text": "Both treatment regimens were safe and well tolerated .", "sentence_id": 8}
+{"abstract_id": "24754529", "label": "results", "text": "Patients ' preference based on the procedure , response rates and future choice favoured MAL-PDT .", "sentence_id": 9}
+{"abstract_id": "24754529", "label": "conclusions", "text": "MAL-PDT and IMIQ @ % are safe and well-tolerated treatments that equally prevent development of new AKs in patients suffering from field changes .", "sentence_id": 10}
+{"abstract_id": "24754529", "label": "conclusions", "text": "MAL-PDT treatment appears to be superior in terms of patients ' preference .", "sentence_id": 11}
+{"abstract_id": "24980392", "label": "background", "text": "DX-@ is a human monoclonal antibody inhibitor of plasma kallikrein under investigation for long-term prophylaxis of hereditary angioedema .", "sentence_id": 0}
+{"abstract_id": "24980392", "label": "objective", "text": "To assess the safety , tolerability , pharmacokinetics , and pharmacodynamics of DX-@ in healthy subjects .", "sentence_id": 1}
+{"abstract_id": "24980392", "label": "methods", "text": "A single-center , double-blinded study was performed in @ healthy subjects randomized @:@ to receive a single subcutaneous administration of DX-@ or placebo within @ of @ sequential , ascending dose cohorts ( n = @ each ) : @ , @ , @ , or @ mg/kg .", "sentence_id": 2}
+{"abstract_id": "24980392", "label": "results", "text": "No dose-limiting toxicity was observed .", "sentence_id": 3}
+{"abstract_id": "24980392", "label": "results", "text": "Headache was the most commonly reported treatment emergent adverse event ( AE ) , occurring at a rate of @ % in the DX-@ - and placebo-treated groups ; none were severe and all resolved .", "sentence_id": 4}
+{"abstract_id": "24980392", "label": "results", "text": "There were no serious AEs , discontinuations owing to an AE , or deaths .", "sentence_id": 5}
+{"abstract_id": "24980392", "label": "results", "text": "Two subjects had a severe AE reported as related to treatment by the blinded investigator ; the @ AEs were asymptomatic creatinine phosphokinase elevations of @ U/L in @ subject receiving @ mg/kg DX-@ and @,@ U/L in @ subject receiving placebo .", "sentence_id": 6}
+{"abstract_id": "24980392", "label": "results", "text": "For the @ - , @ - , @ - , and @-mg / kg dose groups , respectively , mean maximum plasma concentrations were @ , @ , @ , and @ g/mL and mean elimination half-lives were @ , @ , @ , and @ days .", "sentence_id": 7}
+{"abstract_id": "24980392", "label": "results", "text": "Exploratory biomarker assays , involving exvivo activation of the kallikrein pathway , showed dose - and time-dependent inhibition of plasma kallikrein , with evidence of sustained bioactivity consistent with the pharmacokinetics profile .", "sentence_id": 8}
+{"abstract_id": "24980392", "label": "conclusions", "text": "A single administration of DX-@ in healthy subjects up to doses of @ mg/kg was well tolerated without dose-limiting toxicity .", "sentence_id": 9}
+{"abstract_id": "24980392", "label": "conclusions", "text": "Pharmacokinetic and pharmacodynamic data provide evidence fora long-acting biological effect relevant to long-term prophylaxis for hereditary angioedema with C@-inhibitor deficiency .", "sentence_id": 10}
+{"abstract_id": "24375969", "label": "objective", "text": "The impact of a text messaging-assisted lifestyle weight loss intervention on weight change among overweight adults in Beijing was examined .", "sentence_id": 0}
+{"abstract_id": "24375969", "label": "methods", "text": "It was a @-month randomized two arm clinical trial .", "sentence_id": 1}
+{"abstract_id": "24375969", "label": "methods", "text": "The control group received a brief advice session after randomization .", "sentence_id": 2}
+{"abstract_id": "24375969", "label": "methods", "text": "The intervention group received three group sessions , five coaching calls , and a daily text message prompting participants to follow predetermined lifestyle goals .", "sentence_id": 3}
+{"abstract_id": "24375969", "label": "results", "text": "A total of @ participants were randomized .", "sentence_id": 4}
+{"abstract_id": "24375969", "label": "results", "text": "At @ months , controls gained @ @ kg ( @ % @ % ) ( NS ) while intervention participants lost @ @ kg ( @ % @ % ) ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24375969", "label": "results", "text": "Intervention participants decreased waist circumference ( WC ) ( -@ @ cm , p < @ ) , percent body fat ( % BF ) ( -@ % @ % , p = @ ) , and systolic/diastolic blood pressure ( SBP/DBP ) significantly ( -@ @ / -@ @ mmHg ) , while the controls had no change in WC and % BF and increased SBP/DBP by @ @ / @ @ mmHg ( between groups : p = @ / p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24375969", "label": "conclusions", "text": "This text message-assisted lifestyle intervention was effective in reducing weight , WC , % BF , and improving BP .", "sentence_id": 7}
+{"abstract_id": "24375969", "label": "conclusions", "text": "Coupled with the scalable feature of the intervention , this finding is intriguing in light of the potential reach of the intervention for countries like China where mobile phone penetration is high and the obesity rate continues to rise .", "sentence_id": 8}
+{"abstract_id": "25962601", "label": "objective", "text": "Rheumatoid arthritis ( RA ) is a chronic autoimmune disease where TNF - is a central mediator of inflammation , and is cleaved from the cell surface by TACE/ADAM@ .", "sentence_id": 0}
+{"abstract_id": "25962601", "label": "objective", "text": "This metalloproteinase is also responsible for the release of soluble ( s ) CD@ .", "sentence_id": 1}
+{"abstract_id": "25962601", "label": "objective", "text": "Soluble CD@ reflects macrophage activation .", "sentence_id": 2}
+{"abstract_id": "25962601", "label": "objective", "text": "In RA , sCD@ has been suggested as a marker of disease activity and progression .", "sentence_id": 3}
+{"abstract_id": "25962601", "label": "objective", "text": "Our aim is to investigate sCD@ levels in early RA patients .", "sentence_id": 4}
+{"abstract_id": "25962601", "label": "methods", "text": "Soluble CD@ was measured by ELISA from @ RA plasma samples from the OPERA trial .", "sentence_id": 5}
+{"abstract_id": "25962601", "label": "methods", "text": "Averaged disease duration was three months , prior to randomisation with methotrexate ( MTX ) and adalimumab ( DMARD+ADA ) or MTX and placebo ( DMARD+PLA ) .", "sentence_id": 6}
+{"abstract_id": "25962601", "label": "methods", "text": "Soluble CD@ levels were evaluated in relation to clinical disease parameters .", "sentence_id": 7}
+{"abstract_id": "25962601", "label": "results", "text": "Plasma sCD@ at baseline was @ mg/l ( @ mg/l -@ mg/l ) , mean ( @ % CI ) , vs healthy controls : @ mg/l ( @ mg/l - @ mg/l ) , ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25962601", "label": "results", "text": "After three months of treatment sCD@ levels decreased significantly ( average @ % ) in both treatment groups .", "sentence_id": 9}
+{"abstract_id": "25962601", "label": "results", "text": "Significant incremental sCD@ levels followed withdrawal of ADA after @ months of treatment .", "sentence_id": 10}
+{"abstract_id": "25962601", "label": "results", "text": "Baseline sCD@ correlated with CRP and all investigated disease activity markers ( = @-@ @ , p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25962601", "label": "results", "text": "In the DMARD+PLA group baseline sCD@ also correlated with CRP during the follow-up period .", "sentence_id": 12}
+{"abstract_id": "25962601", "label": "conclusions", "text": "Soluble CD@ correlated with disease activity markers in early RA before treatment .", "sentence_id": 13}
+{"abstract_id": "25962601", "label": "conclusions", "text": "Plasma sCD@ may add to currently available disease measures by specifically reflecting changes in macrophage activity as evidenced by increasing levels following anti-TNF withdrawal , despite maintenance of a stable clinical condition achieved by conventional remedies .", "sentence_id": 14}
+{"abstract_id": "25962601", "label": "conclusions", "text": "It remains to be determined whether sCD@ is an early predictor of disease flare .", "sentence_id": 15}
+{"abstract_id": "26027881", "label": "background", "text": "Whether patients with early-stage oral cancers should be treated with elective neck dissection at the time of the primary surgery or with therapeutic neck dissection after nodal relapse has been a matter of debate .", "sentence_id": 0}
+{"abstract_id": "26027881", "label": "methods", "text": "In this prospective , randomized , controlled trial , we evaluated the effect on survival of elective node dissection ( ipsilateral neck dissection at the time of the primary surgery ) versus therapeutic node dissection ( watchful waiting followed by neck dissection for nodal relapse ) in patients with lateralized stage T@ or T@ oral squamous-cell carcinomas .", "sentence_id": 1}
+{"abstract_id": "26027881", "label": "methods", "text": "Primary and secondary end points were overall survival and disease-free survival , respectively .", "sentence_id": 2}
+{"abstract_id": "26027881", "label": "results", "text": "Between @ and @ , a total of @ patients were enrolled .", "sentence_id": 3}
+{"abstract_id": "26027881", "label": "results", "text": "As prespecified by the data and safety monitoring committee , this report summarizes results for the first @ patients ( @ in the elective-surgery group and @ in the therapeutic-surgery group ) , with a median follow-up of @ months .", "sentence_id": 4}
+{"abstract_id": "26027881", "label": "results", "text": "There were @ recurrences and @ deaths in the elective-surgery group and @ recurrences and @ deaths in the therapeutic-surgery group .", "sentence_id": 5}
+{"abstract_id": "26027881", "label": "results", "text": "At @ years , elective node dissection resulted in an improved rate of overall survival ( @ % ; @ % confidence interval -LSB- CI -RSB- , @ to @ ) , as compared with therapeutic dissection ( @ % ; @ % CI , @ to @ ) , for a hazard ratio for death of @ in the elective-surgery group ( @ % CI , @ to @ ; P = @ by the log-rank test ) .", "sentence_id": 6}
+{"abstract_id": "26027881", "label": "results", "text": "At that time , patients in the elective-surgery group also had a higher rate of disease-free survival than those in the therapeutic-surgery group ( @ % vs. @ % , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26027881", "label": "results", "text": "Elective node dissection was superior in most subgroups without significant interactions .", "sentence_id": 8}
+{"abstract_id": "26027881", "label": "results", "text": "Rates of adverse events were @ % and @ % in the elective-surgery group and the therapeutic-surgery group , respectively .", "sentence_id": 9}
+{"abstract_id": "26027881", "label": "conclusions", "text": "Among patients with early-stage oral squamous-cell cancer , elective neck dissection resulted in higher rates of overall and disease-free survival than did therapeutic neck dissection .", "sentence_id": 10}
+{"abstract_id": "26027881", "label": "conclusions", "text": "( Funded by the Tata Memorial Centre ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24722045", "label": "objective", "text": "The goal of this study was to preliminarily test the efficacy of a telephone intervention , Family Intervention : Telephone Tracking , designed to assist stroke survivors and their primary caregivers during the first @ months after stroke .", "sentence_id": 0}
+{"abstract_id": "24722045", "label": "methods", "text": "Forty-nine stroke survivors and their caregivers were randomly assigned to treatment as usual or treatment as usual plus the telephone intervention .", "sentence_id": 1}
+{"abstract_id": "24722045", "label": "methods", "text": "Global outcomes are reported for health care utilization , family functioning , and general functioning .", "sentence_id": 2}
+{"abstract_id": "24722045", "label": "results", "text": "Family and general functioning were positively and significantly changed at @ and @ months .", "sentence_id": 3}
+{"abstract_id": "24722045", "label": "results", "text": "Health care utilization was positively and significantly changed at @ months .", "sentence_id": 4}
+{"abstract_id": "24722045", "label": "conclusions", "text": "Findings suggest that the model has the potential to decrease health care utilization and improve quality of life for stroke survivors and their caregivers .", "sentence_id": 5}
+{"abstract_id": "24722045", "label": "conclusions", "text": "Further study is warranted .", "sentence_id": 6}
+{"abstract_id": "24449733", "label": "objective", "text": "Transesophageal echocardiography has become a standard tool for evaluating left ventricular function during cardiac surgery .", "sentence_id": 0}
+{"abstract_id": "24449733", "label": "objective", "text": "However , the image quality varies widely between patients and examinations .", "sentence_id": 1}
+{"abstract_id": "24449733", "label": "objective", "text": "The aim of this study was to investigate the influence of the image quality on @ commonly used @-dimensional methods .", "sentence_id": 2}
+{"abstract_id": "24449733", "label": "methods", "text": "Transesophageal real-time @-dimensional echocardiography ( @DE ) served as a reference .", "sentence_id": 3}
+{"abstract_id": "24449733", "label": "methods", "text": "Left ventricular function was evaluated in @ patients with sufficient real-time @DE image quality .", "sentence_id": 4}
+{"abstract_id": "24449733", "label": "methods", "text": "The image quality was rated using the ratio of the visualized border divided by the total endocardial border .", "sentence_id": 5}
+{"abstract_id": "24449733", "label": "methods", "text": "These ratings were used to generate groups of poor ( @ % -@ % ) , fair ( @ % -@ % ) , and good ( @ % -@ % ) image quality .", "sentence_id": 6}
+{"abstract_id": "24449733", "label": "methods", "text": "The ejection fraction ( EF ) , end-diastolic volume , and end-systolic volume were analyzed by the Simpson method of disks ( biplane and monoplane ) , eyeball method , Teichholz method , and speckle-tracking method .", "sentence_id": 7}
+{"abstract_id": "24449733", "label": "methods", "text": "Furthermore , the fractional area change was determined .", "sentence_id": 8}
+{"abstract_id": "24449733", "label": "methods", "text": "Each correlation with real-time @DE was evaluated .", "sentence_id": 9}
+{"abstract_id": "24449733", "label": "results", "text": "Correlations of the EF and volumes , respectively , as determined by long-axis view methods increased with improving image quality : the Simpson biplane method was found to be the most accurate method , with good image quality for the EF ( r = @ ) and volumes ( end-diastolic volume , r = @ ; end-systolic volume , r = @ ) .", "sentence_id": 10}
+{"abstract_id": "24449733", "label": "results", "text": "Correlations of the EF and fractional area change by short-axis view methods decreased with improving image quality , with the Teichholz EF found to be most accurate with poor ( r = @ ) in contrast to good ( r = @ ) image quality .", "sentence_id": 11}
+{"abstract_id": "24449733", "label": "conclusions", "text": "With good image quality , the Simpson biplane method is the most accurate @-dimensional method for assessing the left ventricular EF .", "sentence_id": 12}
+{"abstract_id": "24449733", "label": "conclusions", "text": "Short-axis view methods , especially the Teichholz method yield better correlations with poor image quality .", "sentence_id": 13}
+{"abstract_id": "24449733", "label": "conclusions", "text": "The eyeball method was unaffected by image quality .", "sentence_id": 14}
+{"abstract_id": "25228130", "label": "background", "text": "In this study , we aimed to evaluate the protective effect of tight glucose control during cardiopulmonary bypass on myocardium in adult nondiabetic patients undergoing isolated aortic valve replacement in a prospective and randomized trial .", "sentence_id": 0}
+{"abstract_id": "25228130", "label": "methods", "text": "Sixty-five adult nondiabetic patients undergoing selective isolated aortic valve replacement were enrolled and randomly assigned to an insulin group ( patients received a continuous insulin infusion during surgery ; n = @ ) or a control group ( patients were not administered insulin unless their blood glucose level exceeded @ mg/dL ; n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25228130", "label": "methods", "text": "Cardiac troponin I was assayed preoperatively , and then at @ , @ , @ , @ , and @ hours after aortic cross-declamping .", "sentence_id": 2}
+{"abstract_id": "25228130", "label": "methods", "text": "The pre - , intra - , and postoperative relevant data of all selected patients were analyzed .", "sentence_id": 3}
+{"abstract_id": "25228130", "label": "results", "text": "Tight glucose control reduced postoperative peak release by @ % for cardiac troponin I compared with the control group ( @ @ vs @ @ ng/mL ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25228130", "label": "results", "text": "Patients with continuous insulin infusion had lower peak inotropic score during the first postoperative @ hours and peak level of blood glucose ( @ @ vs @ @ g/kg/min ; P < @ ; @ @ vs @ @ mg/dL ; P < @ , respectively ) , shorter duration of mechanical ventilation and intensive care unit stay and hospital stay compared with the control group ( @ @ hours vs @ @ hours ; P = @ ; @ @ hours vs @ @ hours ; P < @ ; @ @ days vs @ @ days ; P = @ , respectively ) .", "sentence_id": 5}
+{"abstract_id": "25228130", "label": "conclusions", "text": "Tight glucose control during cardiopulmonary bypass might provide myocardial protection in adult nondiabetic patients undergoing isolated aortic valve replacement .", "sentence_id": 6}
+{"abstract_id": "24726507", "label": "objective", "text": "The decision of whether to retain or remove a previously placed cervical cerclage in women who subsequently rupture fetal membranes in a premature gestation is controversial and all studies to date are retrospective .", "sentence_id": 0}
+{"abstract_id": "24726507", "label": "objective", "text": "We performed a multicenter randomized controlled trial of removal vs retention of cerclage in these patients to determine whether leaving the cerclage in place prolonged gestation and/or increased the risk of maternal or fetal infection .", "sentence_id": 1}
+{"abstract_id": "24726507", "label": "methods", "text": "A prospective randomized multicenter trial of @ hospitals was performed .", "sentence_id": 2}
+{"abstract_id": "24726507", "label": "methods", "text": "Patients included were those with cerclage placement at @ weeks @ days in singleton or twin pregnancies , with subsequent spontaneous rupture of membranes between @ weeks @ days and @ weeks @ days .", "sentence_id": 3}
+{"abstract_id": "24726507", "label": "methods", "text": "Patients were randomized to retention or removal of cerclage .", "sentence_id": 4}
+{"abstract_id": "24726507", "label": "methods", "text": "Patients were then expectantly managed and delivered only for evidence of labor , chorioamnionitis , fetal distress , or other medical or obstetrical indications .", "sentence_id": 5}
+{"abstract_id": "24726507", "label": "methods", "text": "Management after @ weeks was at the clinician 's discretion .", "sentence_id": 6}
+{"abstract_id": "24726507", "label": "results", "text": "The initial sample size calculation determined that a total of @ patients should be included but after a second interim analysis , futility calculations determined that the conditional power for showing statistical significance after randomizing @ patients for the primary outcome of prolonging pregnancy was @ % .", "sentence_id": 7}
+{"abstract_id": "24726507", "label": "results", "text": "Thus the study was terminated after a total of @ subjects were randomized with complete data available for analysis , @ to removal and @ to retention of cerclage .", "sentence_id": 8}
+{"abstract_id": "24726507", "label": "results", "text": "There was no statistical significance in primary outcome of prolonging pregnancy by @ week comparing the @ groups ( removal @/@ , @ % ; retention @/@ , @ % ) P = @ ; or chorioamnionitis ( removal @/@ , @ % ; retention @/@ , @ % ) P = @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24726507", "label": "results", "text": "There was no statistical difference in composite neonatal outcomes ( removal @/@ , @ % ; retention @/@ , @ % ) , fetal/neonatal death ( removal @/@ , @ % ; retention @/@ , @ % ) ; or gestational age at delivery ( removal mean @ days ; retention mean @ days ) .", "sentence_id": 10}
+{"abstract_id": "24726507", "label": "conclusions", "text": "Statistically significant differences were not seen in prolongation of latency , infection , or composite neonatal outcomes .", "sentence_id": 11}
+{"abstract_id": "24726507", "label": "conclusions", "text": "However , there was a numerical trend in the direction of less infectious morbidity , with immediate removal of cerclage .", "sentence_id": 12}
+{"abstract_id": "24726507", "label": "conclusions", "text": "These findings may not have met statistical significance if the original sample size of @ was obtained , however they provide valuable data suggesting that there may be no advantage to retaining a cerclage after preterm premature rupture of membranes and a possibility of increased infection with cerclage retention .", "sentence_id": 13}
+{"abstract_id": "24871247", "label": "objective", "text": "To compare the speed and accuracy of answering clinical questions using Google versus summary resources .", "sentence_id": 0}
+{"abstract_id": "24871247", "label": "methods", "text": "In @ and @ , @ internal medicine interns from two classes at Rutgers University Robert Wood Johnson Medical School , who had been trained to use three evidence-based summary resources , performed four-minute computer searches to answer @ clinical questions .", "sentence_id": 1}
+{"abstract_id": "24871247", "label": "methods", "text": "Half were randomized to initiate searches for answers to questions @ to @ using Google ; the other half initiated searches using a summary resource .", "sentence_id": 2}
+{"abstract_id": "24871247", "label": "methods", "text": "They then crossed over and used the other resource for questions @ to @ .", "sentence_id": 3}
+{"abstract_id": "24871247", "label": "methods", "text": "They documented the time spent searching and the resource where the answer was found .", "sentence_id": 4}
+{"abstract_id": "24871247", "label": "methods", "text": "Time to correct response and percentage of correct responses were compared between groups using t test and general estimating equations .", "sentence_id": 5}
+{"abstract_id": "24871247", "label": "results", "text": "Of @ questions administered , interns found answers for @ ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "24871247", "label": "results", "text": "Interns initiating searches in Google used a wider variety of resources than those starting with summary resources .", "sentence_id": 7}
+{"abstract_id": "24871247", "label": "results", "text": "No significant difference was found in mean time to correct response ( @ seconds for Google versus @ seconds for summary resource ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24871247", "label": "results", "text": "Mean correct response rate was @ % for Google versus @ % for summary resource ( mean difference -@ % ; @ % CI -@ % to @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24871247", "label": "conclusions", "text": "The authors found no significant differences in speed or accuracy between searches initiated using Google versus summary resources .", "sentence_id": 10}
+{"abstract_id": "24871247", "label": "conclusions", "text": "Although summary resources are considered to provide the highest quality of evidence , improvements to allow for better speed and accuracy are needed .", "sentence_id": 11}
+{"abstract_id": "24510077", "label": "objective", "text": "To assess LASIK flaps made by femtosecond laser and mechanical microkeratome .", "sentence_id": 0}
+{"abstract_id": "24510077", "label": "methods", "text": "Clinical , prospective , randomized , masked study of @ eyes ( @ patients ) .", "sentence_id": 1}
+{"abstract_id": "24510077", "label": "methods", "text": "Both eyes of all patients were operated , each patient underwent different techniques for lasik .", "sentence_id": 2}
+{"abstract_id": "24510077", "label": "methods", "text": "Microkeratome Hansatome ( TM ) Bausch & Lomb ( group microkeratome ) was used in one eye and femtosecond laser Femto LDV ( TM ) Ziemer ( group femtosecond ) was used for the fellow eye .", "sentence_id": 3}
+{"abstract_id": "24510077", "label": "methods", "text": "Patients were selected from the Refractive Surgery service of the Eye Hospital of Paran between July @ and September @ .", "sentence_id": 4}
+{"abstract_id": "24510077", "label": "methods", "text": "Inclusion criteria were myopia less than @ D , astigmatism less than @ D , hyperopia less than @ D , stable refraction over one year , corneal diameter smaller than @ mm , discontinuation of contact lenses seven days before the preoperative evaluation , corrected visual acuity of at least @/@ .", "sentence_id": 5}
+{"abstract_id": "24510077", "label": "methods", "text": "Eyes were randomly allocated for each technique .", "sentence_id": 6}
+{"abstract_id": "24510077", "label": "methods", "text": "The studied variables were : visual acuity with and without correction , residual refractive error , high order aberrations , low contrast visual acuity , complications and subjective patient preference .", "sentence_id": 7}
+{"abstract_id": "24510077", "label": "results", "text": "All studied variables were similar between the two groups .", "sentence_id": 8}
+{"abstract_id": "24510077", "label": "conclusions", "text": "We could not demonstrate any difference between the studied groups .", "sentence_id": 9}
+{"abstract_id": "24472058", "label": "background", "text": "Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second-generation H@ - antihistamine in the morning and a sedating first-generation H@ - antihistamine , usually hydroxyzine , at night to enhance sleep .", "sentence_id": 0}
+{"abstract_id": "24472058", "label": "background", "text": "But is this belief well founded ?", "sentence_id": 1}
+{"abstract_id": "24472058", "label": "objective", "text": "To test this belief by comparing the effectiveness and prevalence of unwanted sedative effects when treating patients with chronic spontaneous urticaria ( CSU ) with levocetirizine @ mg daily plus hydroxyzine @ mg at night ( levocetirizine plus hydroxyzine ) vs. levocetirizine @ mg daily ( levocetirizine monotherapy ) .", "sentence_id": 2}
+{"abstract_id": "24472058", "label": "methods", "text": "In this randomized , double-blind , cross-over study , @ patients with difficult-to-treat CSU took levocetirizine plus hydroxyzine or levocetirizine monotherapy for periods of @ days each .", "sentence_id": 3}
+{"abstract_id": "24472058", "label": "methods", "text": "At the end of each treatment period , assessments were made of quality of life ( Chronic Urticaria Quality of Life Questionnaire , CU-Q@ oL ) , severity of urticaria symptoms ( Urticaria Activity Score , UAS ) , sleep disturbance during the night and daytime somnolence .", "sentence_id": 4}
+{"abstract_id": "24472058", "label": "results", "text": "Both treatments significantly decreased UAS , night-time sleep disturbances and CU-Q@ oL scores ( P < @ ) without significant differences between the two .", "sentence_id": 5}
+{"abstract_id": "24472058", "label": "results", "text": "Compared with baseline , daytime somnolence was significantly reduced by levocetirizine monotherapy ( P = @ ) but not by levocetirizine plus hydroxyzine ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24472058", "label": "results", "text": "Direct comparison of the two treatment modalities in terms of daytime somnolence favoured levocetirizine monotherapy ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24472058", "label": "conclusions", "text": "The widespread belief that sleep is aided by the addition of a sedating first-generation H@ - antihistamine , usually hydroxyzine , at night is not supported .", "sentence_id": 8}
+{"abstract_id": "24472058", "label": "conclusions", "text": "These results are in line with the urticaria guidelines , which state that first-line treatment for urticaria should be new-generation , nonsedating H@ - antihistamines only .", "sentence_id": 9}
+{"abstract_id": "25440437", "label": "background", "text": "Lignin peroxidase is a cosmetic skin-lightening alternative that breaks down plant cell walls and melanin .", "sentence_id": 0}
+{"abstract_id": "25440437", "label": "objective", "text": "This research examined the topical efficacy of lignin peroxidase in pigment lightening .", "sentence_id": 1}
+{"abstract_id": "25440437", "label": "methods", "text": "Sixty women aged @ to @ years with mild to moderate facial dyspigmentation were enrolled for @ weeks in @ cohorts .", "sentence_id": 2}
+{"abstract_id": "25440437", "label": "methods", "text": "Cohort @ applied lignin peroxidase to @ randomized side of the face and nothing to the opposite side .", "sentence_id": 3}
+{"abstract_id": "25440437", "label": "methods", "text": "Cohort @ applied lignin peroxidase to @ facial side and generic hydroquinone to the other .", "sentence_id": 4}
+{"abstract_id": "25440437", "label": "methods", "text": "Investigator , subject , and dermospectrophotometer measurements were obtained .", "sentence_id": 5}
+{"abstract_id": "25440437", "label": "results", "text": "In cohort @ , improved skin texture ( P < @ ) , roughness ( P < @ ) , and overall appearance ( P = @ ) was noted at week @ with lignin peroxidase versus no treatment .", "sentence_id": 6}
+{"abstract_id": "25440437", "label": "results", "text": "By week @ , there was a decrease in spot size with lignin peroxidase versus no treatment ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25440437", "label": "results", "text": "This was confirmed by a statistically significant reduction in melanin scores with the dermospectrophotometer on lignin peroxidase-treated side at weeks @ , @ , and @ ( P = @ ) and a similar reduction in Melasma Area Severity Index score .", "sentence_id": 8}
+{"abstract_id": "25440437", "label": "results", "text": "Cohort @ demonstrated parity between lignin peroxidase and hydroquinone , but lignin peroxidase was statistically superior in skin texture and roughness .", "sentence_id": 9}
+{"abstract_id": "25440437", "label": "conclusions", "text": "The sample size was limited .", "sentence_id": 10}
+{"abstract_id": "25440437", "label": "conclusions", "text": "Lignin peroxidase might be an over-the-counter skin-lightening preparation with efficacy parity to hydroquinone .", "sentence_id": 11}
+{"abstract_id": "25374230", "label": "background", "text": "Increasing evidence suggests that stromal monocarboxylate transporter @ ( MCT@ ) and carbonic anhydrase IX ( CA IX ) may play key roles in tumor development .", "sentence_id": 0}
+{"abstract_id": "25374230", "label": "background", "text": "However , their clinical value remains largely unexplored in gastric cancer ( GC ) .", "sentence_id": 1}
+{"abstract_id": "25374230", "label": "background", "text": "The present study aimed to determine clinicopathological significance and prognostic values of stromal MCT@ and CA IX in GC .", "sentence_id": 2}
+{"abstract_id": "25374230", "label": "methods", "text": "Specimens from @ GC patients were immunohistochemically stained using polyclonal anti-MCT@ and anti-CA IX antibodies .", "sentence_id": 3}
+{"abstract_id": "25374230", "label": "methods", "text": "Expression was correlated with patient clinicopathologic characteristics and survival data .", "sentence_id": 4}
+{"abstract_id": "25374230", "label": "results", "text": "High stromal MCT@ expression was detected in @ of @ ( @ % ) GCs and high CA IX in @ ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25374230", "label": "results", "text": "Both high stromal MCT@ and CA IX were correlated with advanced TNM stage ( p = @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25374230", "label": "results", "text": "High CA IX expression was positively related to depth of invasion ( p = @ ) and positive lymph nodes ( p = @ ) as well .", "sentence_id": 7}
+{"abstract_id": "25374230", "label": "results", "text": "Survival analysis indicated high expression of stromal MCT@ to be an independent factor in predicting poor overall survival ( OS ) ( HR and @ % CI = @ , @-@ @ , p = @ ) and disease free survival ( DFS ) ( HR and @ % CI = @ , @-@ @ , p = @ ) of GC patients .", "sentence_id": 8}
+{"abstract_id": "25374230", "label": "results", "text": "However , high CA IX expression exhibited no significant predictive value .", "sentence_id": 9}
+{"abstract_id": "25374230", "label": "conclusions", "text": "These findings suggest that high expression of stromal MCT@ and CA IX proteins is significantly correlated with GC progression .", "sentence_id": 10}
+{"abstract_id": "25374230", "label": "conclusions", "text": "High stromal MCT@ heralds worse outcome of GC patient , suggesting a novel candidate prognostic marker and therapeutic target .", "sentence_id": 11}
+{"abstract_id": "25916135", "label": "objective", "text": "To study the prevalence of H. pylori CagA strain and the activity of associated gastritis in schoolchildren of Tyva Republic ( Russia ) .", "sentence_id": 0}
+{"abstract_id": "25916135", "label": "methods", "text": "The cohorts had been formed out of @ native and alien schoolchildren picked up by random in Tyva Republic in the ages from @ to @ years .", "sentence_id": 1}
+{"abstract_id": "25916135", "label": "methods", "text": "We determined IgG to H. pylori CagA antigen in serum ( @ aliens and @ natives ) .", "sentence_id": 2}
+{"abstract_id": "25916135", "label": "methods", "text": "Out them @ Tuvins and @ Europoids with dyspeptic complaints were provided with endoscopic tests including biopsy of mucosa of antrum and stomach body .", "sentence_id": 3}
+{"abstract_id": "25916135", "label": "results", "text": "We had found ethnic peculiarities in the obtained indices in children , namely higher prevalence of the said strain of H. pylori and the absence of meaningful activity in antral sector and body of stomach in CagA-seropositive native children as compared to alien ones , in whom the activity of antral gastritis was higher than the activity in body of stomach .", "sentence_id": 4}
+{"abstract_id": "24814814", "label": "objective", "text": "To compare isoflurane and propofol for maintenance of anesthesia and quality of recovery in client-owned dogs with intracranial disease undergoing magnetic resonance imaging ( MRI ) .", "sentence_id": 0}
+{"abstract_id": "24814814", "label": "methods", "text": "Prospective , randomized , clinical trial .", "sentence_id": 1}
+{"abstract_id": "24814814", "label": "methods", "text": "Twenty-five client-owned dogs with intracranial pathology , @ females and @ males , ages @months to @years , weighing between @ and @ kg .", "sentence_id": 2}
+{"abstract_id": "24814814", "label": "methods", "text": "Each dog was randomly assigned to receive propofol or isoflurane for maintenance of anesthesia .", "sentence_id": 3}
+{"abstract_id": "24814814", "label": "methods", "text": "All dogs were not premedicated , were administered propofol intravenously to effect for induction , intubated and mechanically ventilated to maintain an end-tidal carbon dioxide tension @-@mmHg ( @-@ @ kPa ) .", "sentence_id": 4}
+{"abstract_id": "24814814", "label": "methods", "text": "Temperature and cardiac output were measured pre - and post-MRI .", "sentence_id": 5}
+{"abstract_id": "24814814", "label": "methods", "text": "Scores for mentation , neurological status , ease of maintenance , and recovery were obtained pre - and post-anesthesia .", "sentence_id": 6}
+{"abstract_id": "24814814", "label": "methods", "text": "Pulse oximetry , end-tidal gases , arterial blood pressure , heart rate ( HR ) and requirements for dopamine administration to maintain mean arterial pressure ( MAP ) > @mmHg were recorded throughout anesthesia .", "sentence_id": 7}
+{"abstract_id": "24814814", "label": "results", "text": "End-tidal isoflurane concentration was @ % and propofol infusion rate was @gkg ( -@ ) minute ( -@ ) .", "sentence_id": 8}
+{"abstract_id": "24814814", "label": "results", "text": "Cardiac index was higher , while HR was lower , with propofol than isoflurane in dogs younger than @years , but not in older dogs .", "sentence_id": 9}
+{"abstract_id": "24814814", "label": "results", "text": "Dogs maintained with isoflurane were @ times more likely to require dopamine than propofol dogs .", "sentence_id": 10}
+{"abstract_id": "24814814", "label": "results", "text": "Mentation and maintenance scores and temperature were not different .", "sentence_id": 11}
+{"abstract_id": "24814814", "label": "results", "text": "MAP and diastolic arterial pressure were higher in the propofol group .", "sentence_id": 12}
+{"abstract_id": "24814814", "label": "results", "text": "Recovery scores were better with propofol , although times to extubation were similar .", "sentence_id": 13}
+{"abstract_id": "24814814", "label": "results", "text": "Change in neurological score from pre - to post-anesthesia was not different between treatments .", "sentence_id": 14}
+{"abstract_id": "24814814", "label": "conclusions", "text": "Dogs maintained with propofol during MRI had higher arterial pressures , decreased requirements for dopamine , and better recovery scores , compared to dogs maintained with isoflurane .", "sentence_id": 15}
+{"abstract_id": "24814814", "label": "conclusions", "text": "Propofol anesthesia offered cardiovascular and recovery advantages over isoflurane during MRI in dogs with intracranial disease in this study .", "sentence_id": 16}
+{"abstract_id": "24551191", "label": "objective", "text": "This study reported on correlates of parental perception of their child 's weight status .", "sentence_id": 0}
+{"abstract_id": "24551191", "label": "objective", "text": "Associations between parental misperception ( i.e. , underestimation of the child 's weight ) and parental intention to improve their child 's overweight-related health behaviors and their child meeting guidelines regarding these behaviors were also investigated .", "sentence_id": 1}
+{"abstract_id": "24551191", "label": "methods", "text": "Baseline data from the population-based ` Be active , eat right study ' were used .", "sentence_id": 2}
+{"abstract_id": "24551191", "label": "methods", "text": "The population for analysis consisted of @ overweight and @ obese five year-old children and their parents .", "sentence_id": 3}
+{"abstract_id": "24551191", "label": "methods", "text": "Questionnaires were used to measure parental perception of the child 's weight status , correlates of misperception ( i.e. , child age , child gender , child BMI , parental age , parental gender , parental country of birth , parental educational level and parental weight status ) , overweight-related health behaviors ( i.e. , child playing outside , having breakfast , drinking sweet beverages , and watching TV ) , and parental intention to improve these behaviors .", "sentence_id": 4}
+{"abstract_id": "24551191", "label": "methods", "text": "Height and weight were measured using standardized protocols .", "sentence_id": 5}
+{"abstract_id": "24551191", "label": "methods", "text": "Multivariable logistic regression analyses were performed .", "sentence_id": 6}
+{"abstract_id": "24551191", "label": "results", "text": "In total , @ % of the parents misperceived their child 's weight status .", "sentence_id": 7}
+{"abstract_id": "24551191", "label": "results", "text": "Parental misperception was associated with lower child BMI , the parent being the father , a foreign parental country of birth , and a lower parental education level ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24551191", "label": "results", "text": "Parental misperception was not associated with parental intention to improve child overweight-related health behavior , nor with child meeting the guidelines of these behaviors .", "sentence_id": 9}
+{"abstract_id": "24551191", "label": "conclusions", "text": "This study showed that almost half of the parents with an overweight or obese child misperceived their child 's weight status .", "sentence_id": 10}
+{"abstract_id": "24551191", "label": "conclusions", "text": "A correct parental perception may be a small stepping-stone in improving the health of overweight and obese children .", "sentence_id": 11}
+{"abstract_id": "25458326", "label": "objective", "text": "To assess the beneficial effects of the components of lifestyle intervention in reducing incidence of diabetes in Asian Indian men with impaired glucose tolerance ( IGT ) in India .", "sentence_id": 0}
+{"abstract_id": "25458326", "label": "methods", "text": "This analysis was based on a @ year prospective , randomized controlled primary prevention trial in a cohort of Asian Indian men with IGT ( n = @ ) ( Clinical Trial No : NCT@ ) .", "sentence_id": 1}
+{"abstract_id": "25458326", "label": "methods", "text": "Intervention and control groups were given standard care advice at baseline .", "sentence_id": 2}
+{"abstract_id": "25458326", "label": "methods", "text": "Additionally , the intervention group received frequent , mobile phone based text message reminders on healthy lifestyle principles .", "sentence_id": 3}
+{"abstract_id": "25458326", "label": "methods", "text": "Dietary intake and physical activity habits were recorded by validated questionnaires .", "sentence_id": 4}
+{"abstract_id": "25458326", "label": "methods", "text": "The lifestyle goals were : reductions in consumption of carbohydrates , oil , portion size and body mass index of at least @ unit ( @ kg/m ( @ ) ) from baseline and maintenance of good physical activity .", "sentence_id": 5}
+{"abstract_id": "25458326", "label": "methods", "text": "The association between diabetes and lifestyle goals achieved was assessed using multiple logistic regression analyses .", "sentence_id": 6}
+{"abstract_id": "25458326", "label": "methods", "text": "Changes in insulin sensitivity ( Matsuda 's insulin sensitivity index ) and oral disposition index during the follow-up were assessed .", "sentence_id": 7}
+{"abstract_id": "25458326", "label": "results", "text": "At the end of the study , @ ( @ % ) participants developed diabetes .", "sentence_id": 8}
+{"abstract_id": "25458326", "label": "results", "text": "The mean lifestyle score was higher in the intervention group compared with control ( @ @ vs. @ @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25458326", "label": "results", "text": "Among the @ lifestyle variables , significant improvements in the @ dietary goal were seen with intervention .", "sentence_id": 10}
+{"abstract_id": "25458326", "label": "results", "text": "Concomitant improvement in insulin sensitivity and oral disposition index was noted .", "sentence_id": 11}
+{"abstract_id": "25458326", "label": "results", "text": "Higher lifestyle score was associated with lower risk of developing diabetes ( odds ratio : @ -LSB- @ % CI : @-@ @ -RSB- ; P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25458326", "label": "conclusions", "text": "Beneficial effects of intervention were associated with increased compliance to lifestyle goals .", "sentence_id": 13}
+{"abstract_id": "25458326", "label": "conclusions", "text": "The plausible mechanism is through improvement in insulin sensitivity and beta cell preservation .", "sentence_id": 14}
+{"abstract_id": "24325112", "label": "objective", "text": "To investigate the safety and efficay of low-dose furosemide in the correction of oliguria in the patients undergoing gynecologic surgery .", "sentence_id": 0}
+{"abstract_id": "24325112", "label": "methods", "text": "A total of @ patients , aged between @ to @ years old , who were scheduled to receive elective gynecological open surgery under general anesthesia , were randomly divided into @ groups : the control group , furosemide @ mg/kg ( F@ @ ) group and furosemide @ mg/kg ( F@ ) group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24325112", "label": "methods", "text": "During surgery , blood volume and blood pressure was maintained in the normal range .", "sentence_id": 2}
+{"abstract_id": "24325112", "label": "methods", "text": "The urine volume was recorded every @ minutes .", "sentence_id": 3}
+{"abstract_id": "24325112", "label": "methods", "text": "Oliguria was defined as the urine volume less than @ mL / ( kg .", "sentence_id": 4}
+{"abstract_id": "24325112", "label": "methods", "text": "h ) , When oliguria was observed , flurosemide or saline was given to the patients based on the enrollment status .", "sentence_id": 5}
+{"abstract_id": "24325112", "label": "methods", "text": "If the patients were still oliguric @ min later , the treatment was repeated .", "sentence_id": 6}
+{"abstract_id": "24325112", "label": "methods", "text": "The total time of surgery , net fluid infusion volume , urine volume per unit time per body weight at the completion of surgery , the incidence of intraoperative oliguria , the total amount of furosemide and the average specific gravity of urine were recorded .", "sentence_id": 7}
+{"abstract_id": "24325112", "label": "results", "text": "There was no statistically significant difference in sex , age , fasting time , the total time of surgery and intraoperative net fluid infusion volume among the three groups ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24325112", "label": "results", "text": "The urine volume per unit time per body weight in control group was significantly lower than that of the other two groups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24325112", "label": "results", "text": "The incidence of intraoperative oliguria in the three groups ( control , low dose , high dose groups ) were @ % , @ % and @ % , respectively ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24325112", "label": "conclusions", "text": "Low-dose of furosemide could maintain normal urine volume and specific gravity of urine during gynecological surgery .", "sentence_id": 11}
+{"abstract_id": "25540891", "label": "background", "text": "Ebola virus and Marburg virus cause serious disease outbreaks with high case fatality rates .", "sentence_id": 0}
+{"abstract_id": "25540891", "label": "background", "text": "We aimed to assess the safety and immunogenicity of two investigational DNA vaccines , one ( EBO vaccine ) encoding Ebola virus Zaire and Sudan glycoproteins and one ( MAR ) encoding Marburg virus glycoprotein .", "sentence_id": 1}
+{"abstract_id": "25540891", "label": "methods", "text": "RV @ was a phase @b , double-blinded , randomised , placebo-controlled clinical trial in Kampala , Uganda to examine the safety and immunogenicity of the EBO and MAR vaccines given individually and concomitantly .", "sentence_id": 2}
+{"abstract_id": "25540891", "label": "methods", "text": "Healthy adult volunteers aged @-@ years were randomly assigned ( @:@ ) to receive three injections of vaccine or placebo at weeks @ , @ , and @ , with vaccine allocations divided equally between three active vaccine groups : EBO vaccine only , MAR vaccine only , and both vaccines .", "sentence_id": 3}
+{"abstract_id": "25540891", "label": "methods", "text": "The primary study objective was to investigate the safety and tolerability of the vaccines , as assessed by local and systemic reactogenicity and adverse events .", "sentence_id": 4}
+{"abstract_id": "25540891", "label": "methods", "text": "We also assessed immunogenicity on the basis of antibody responses ( ELISA ) and T-cell responses ( ELISpot and intracellular cytokine staining assays ) @ weeks after the third injection .", "sentence_id": 5}
+{"abstract_id": "25540891", "label": "methods", "text": "Participants and investigators were masked to group assignment .", "sentence_id": 6}
+{"abstract_id": "25540891", "label": "methods", "text": "Analysis was based on the intention-to-treat principle .", "sentence_id": 7}
+{"abstract_id": "25540891", "label": "methods", "text": "This trial is registered at ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "25540891", "label": "results", "text": "@ participants were enrolled into the study between Nov @ , @ , and April @ , @ .", "sentence_id": 9}
+{"abstract_id": "25540891", "label": "results", "text": "All @ participants received at least one study injection ( including @ who completed the injection schedule ) and were included in safety and tolerability analyses ; @ for whom data were available were included in the immunogenicity analyses .", "sentence_id": 10}
+{"abstract_id": "25540891", "label": "results", "text": "Study injections were well tolerated , with no significant differences in local or systemic reactions between groups .", "sentence_id": 11}
+{"abstract_id": "25540891", "label": "results", "text": "The vaccines elicited antibody and T-cell responses specific to the glycoproteins received and we detected no differences between the separate and concomitant use of the two vaccines .", "sentence_id": 12}
+{"abstract_id": "25540891", "label": "results", "text": "@ of @ ( @ % , @ % CI @-@ ) participants in the EBO vaccine group had an antibody response to the Ebola Zaire glycoprotein , as did @ of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 13}
+{"abstract_id": "25540891", "label": "results", "text": "@ of @ ( @ % , @-@ ) participants in the EBO vaccine group had an antibody response to the Ebola Sudan glycoprotein , as did @ of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 14}
+{"abstract_id": "25540891", "label": "results", "text": "Nine of @ ( @ % , @-@ ) participants in the MAR vaccine groups had an antibody response to the Marburg glycoprotein , as did seven of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 15}
+{"abstract_id": "25540891", "label": "results", "text": "@ of @ ( @ % , @-@ ) participants in the EBO vaccine group had a T-cell response to the Ebola Zaire glycoprotein , as did @ of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 16}
+{"abstract_id": "25540891", "label": "results", "text": "@ of @ ( @ % , @-@ ) participants in the EBO vaccine group had a T-cell response to the Ebola Sudan glycoprotein , as did @ of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 17}
+{"abstract_id": "25540891", "label": "results", "text": "@ of @ ( @ % , @-@ ) participants in the MAR vaccine group had a T-cell response to the Marburg glycoprotein , as did @ of @ ( @ % , @-@ ) in the group that received both vaccines .", "sentence_id": 18}
+{"abstract_id": "25540891", "label": "conclusions", "text": "This study is the first Ebola or Marburg vaccine trial done in Africa , and the results show that , given separately or together , both vaccines were well tolerated and elicited antigen-specific humoral and cellular immune responses .", "sentence_id": 19}
+{"abstract_id": "25540891", "label": "conclusions", "text": "These findings have contributed to the accelerated development of more potent Ebola virus vaccines that encode the same wild-type glycoprotein antigens as the EBO vaccine , which are being assessed during the @ Ebola virus disease outbreak in west Africa .", "sentence_id": 20}
+{"abstract_id": "25304298", "label": "background", "text": "Cure of lung cancer is impossible without local tumour control .", "sentence_id": 0}
+{"abstract_id": "25304298", "label": "background", "text": "This can be compromised by accelerated repopulation of tumour cells during radiotherapy and chemotherapy .", "sentence_id": 1}
+{"abstract_id": "25304298", "label": "background", "text": "A strategy to minimise accelerated repopulation might improve local control .", "sentence_id": 2}
+{"abstract_id": "25304298", "label": "background", "text": "We investigated whether concurrent chemo-radiotherapy could be given safely over four weeks .", "sentence_id": 3}
+{"abstract_id": "25304298", "label": "methods", "text": "We conducted a randomised phase II trial in which patients with inoperable Stage III Non-Small Cell Lung Cancer ( NSCLC ) received a radical radiation dose over four weeks rather than conventional fractionation .", "sentence_id": 4}
+{"abstract_id": "25304298", "label": "methods", "text": "Treatment was given either sequentially or concurrently with three to four cycles of cisplatinum and vinorelbine .", "sentence_id": 5}
+{"abstract_id": "25304298", "label": "methods", "text": "@ patients with inoperable stage III NSCLC and PS @-@ were randomised to receive cisplatinum and vinorelbine with either sequential or concurrent chemo-radiation using @Gy in @ fractions over four weeks .", "sentence_id": 6}
+{"abstract_id": "25304298", "label": "methods", "text": "The primary end-point was treatment related mortality .", "sentence_id": 7}
+{"abstract_id": "25304298", "label": "methods", "text": "Secondary end-points were toxicity and survival .", "sentence_id": 8}
+{"abstract_id": "25304298", "label": "results", "text": "Treatment related mortality was : @ % ( exact @ % confidence interval -LSB- CI -RSB- @-@ @ % ) and @ % ( exact @ % CI @-@ @ % ) for the Concurrent and Sequential group respectively ; relative risk ( RR ) @ ; ( @ % CI @ , @ ) .", "sentence_id": 9}
+{"abstract_id": "25304298", "label": "results", "text": "Toxicity was similar between arms ; grade @ or worse oesophagitis was @ % versus @ % ; RR @ ( @ % CI @ , @ ) .", "sentence_id": 10}
+{"abstract_id": "25304298", "label": "results", "text": "OS HR was @ ; @ % CI ( @-@ @ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25304298", "label": "results", "text": "The @ year overall survival rates were : @ % versus @ % ; RR @ ( @ % CI @ , @ ) for Concurrent versus Sequential .", "sentence_id": 12}
+{"abstract_id": "25304298", "label": "conclusions", "text": "A strategy to minimise the effects of accelerated repopulation using accelerated hypofractionated radiotherapy with chemotherapy is feasible , and reasonably safe for patients with stage III NSCLC .", "sentence_id": 13}
+{"abstract_id": "25304298", "label": "conclusions", "text": "The reported two year survival is promising and suggests that a four week regime of radiotherapy should be compared with conventionally fractionated radiotherapy in an adequately powered randomised controlled phase III trial .", "sentence_id": 14}
+{"abstract_id": "25296647", "label": "objective", "text": "In this paper , we describe a trial protocol used to assess feasibility related to : study administration ( recruitment , randomization , retention , compliance , eligibility criteria , suitability of protocol instructions and data collection questionnaires ) ; resource and data management ( suitability of site , time and budget allocation , management of personnel and data ) ; intervention fidelity ( treatment dose , violations ) ; and effect size .", "sentence_id": 0}
+{"abstract_id": "25296647", "label": "background", "text": "Pressure injury can lead to increases in hospital length of stay and cost .", "sentence_id": 1}
+{"abstract_id": "25296647", "label": "background", "text": "The sacrum is identified as one of the most common anatomical pressure injury sites for hospitalized patients .", "sentence_id": 2}
+{"abstract_id": "25296647", "label": "background", "text": "Silicone foam border dressings have been proposed as one strategy to reduce pressure injury incidence ; however , rigorous testing of benefit in a general medical-surgical population is required .", "sentence_id": 3}
+{"abstract_id": "25296647", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 4}
+{"abstract_id": "25296647", "label": "methods", "text": "Eighty patients will be recruited after assessment of high risk of pressure injury in a large tertiary hospital in south-east Queensland , Australia .", "sentence_id": 5}
+{"abstract_id": "25296647", "label": "methods", "text": "Eligible , consenting participants will be randomly allocated to either a control group ( routine care ) or an intervention group ( routine care and a sacral prophylactic dressing ) .", "sentence_id": 6}
+{"abstract_id": "25296647", "label": "methods", "text": "The primary outcomes comprise feasibility criteria as identified above .", "sentence_id": 7}
+{"abstract_id": "25296647", "label": "methods", "text": "The secondary measure is the presence and severity of sacral pressure injury via blind assessment of digital photographs .", "sentence_id": 8}
+{"abstract_id": "25296647", "label": "methods", "text": "Research ethics approval was received in October @ .", "sentence_id": 9}
+{"abstract_id": "25296647", "label": "conclusions", "text": "Prophylactic dressings applied to the sacrum may be an effective method for reducing pressure injury in high-risk general medical-surgical patients .", "sentence_id": 10}
+{"abstract_id": "25296647", "label": "conclusions", "text": "However , more rigorous studies to confirm benefit are required .", "sentence_id": 11}
+{"abstract_id": "25296647", "label": "conclusions", "text": "This pilot study will determine the feasibility and effect size to inform a larger randomized controlled trial .", "sentence_id": 12}
+{"abstract_id": "24423146", "label": "background", "text": "Group cognitive behavioural intervention ( CBI ) is effective in reducing low-back pain and disability in comparison to advice in primary care .", "sentence_id": 0}
+{"abstract_id": "24423146", "label": "background", "text": "The aim of this analysis was to investigate the impact of compliance on estimates of treatment effect and to identify factors associated with compliance .", "sentence_id": 1}
+{"abstract_id": "24423146", "label": "methods", "text": "In this multicentre trial , @ adults with troublesome sub-acute or chronic low-back pain were recruited from @ general practices .", "sentence_id": 2}
+{"abstract_id": "24423146", "label": "methods", "text": "Participants were randomised to advice ( control n = @ ) or advice plus CBI ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24423146", "label": "methods", "text": "Compliance was specified a priori as attending a minimum of three group sessions and the individual assessment .", "sentence_id": 4}
+{"abstract_id": "24423146", "label": "methods", "text": "We estimated the complier average causal effect ( CACE ) of treatment .", "sentence_id": 5}
+{"abstract_id": "24423146", "label": "results", "text": "Comparison of the CACE estimate of the mean treatment difference to the intention-to-treat ( ITT ) estimate at @ months showed a greater benefit of CBI amongst participants compliant with treatment on the Roland Morris Questionnaire ( CACE : @ points , @ % CI @ to @ ; ITT : @ points , @ % CI @ to @ ) , the Modified Von Korff disability score ( CACE : @ points , @ % CI @ to @ ; ITT : @ points , @ % CI @ to @ ) and the Modified von Korff pain score ( CACE : @ points , @ % CI @ to @ ; ITT : @ points , @ % CI @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "24423146", "label": "results", "text": "People who were non-compliant were younger and had higher pain scores at randomisation .", "sentence_id": 7}
+{"abstract_id": "24423146", "label": "conclusions", "text": "Treatment compliance is important in the effectiveness of group CBI .", "sentence_id": 8}
+{"abstract_id": "24423146", "label": "conclusions", "text": "Younger people and those with more pain are at greater risk of non-compliance .", "sentence_id": 9}
+{"abstract_id": "25071901", "label": "objective", "text": "The use of proton pump inhibitors or misoprostol is known to prevent the gastrointestinal complications of nonsteroidal anti-inflammatory drugs ( NSAIDs ) .", "sentence_id": 0}
+{"abstract_id": "25071901", "label": "objective", "text": "Rebamipide is known to increase the mucosal generation of prostaglandins and to eliminate free oxygen radicals , thus enhancing the protective function of the gastric mucosa .", "sentence_id": 1}
+{"abstract_id": "25071901", "label": "objective", "text": "However , it is unknown whether rebamipide plays a role in preventing NSAID-induced gastropathy .", "sentence_id": 2}
+{"abstract_id": "25071901", "label": "objective", "text": "The aim of this study was to determine the effectiveness of rebamipide compared to misoprostol in preventing NSAID-induced gastrointestinal complications in patients requiring continuous NSAID treatment .", "sentence_id": 3}
+{"abstract_id": "25071901", "label": "methods", "text": "We studied @ patients who required continuous NSAID treatment .", "sentence_id": 4}
+{"abstract_id": "25071901", "label": "methods", "text": "The patients were randomly assigned to groups that received @ mg of rebamipide three times per day or @ g of misoprostol three times per day for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25071901", "label": "methods", "text": "The primary endpoint of the analysis was the occurrence rate of gastric ulcers , as determined by endoscopy after @ weeks of therapy .", "sentence_id": 6}
+{"abstract_id": "25071901", "label": "results", "text": "Of the @ patients in the study , @ received rebamipide , and @ received misoprostol .", "sentence_id": 7}
+{"abstract_id": "25071901", "label": "results", "text": "Ultimately , @ patients ( @ % ) withdrew from the misoprostol group and @ patients ( @ % ) withdrew from the rebamipide group .", "sentence_id": 8}
+{"abstract_id": "25071901", "label": "results", "text": "There was a significant difference in withdrawal rate between the two groups ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25071901", "label": "results", "text": "The per protocol analysis set was not valid because of the dropout rate of the misoprostol group ; thus , the intention to treat ( ITT ) analysis set is the main set for the efficacy analysis in this study .", "sentence_id": 10}
+{"abstract_id": "25071901", "label": "results", "text": "After @ weeks , the occurrence rate of gastric ulcers was similar in the rebamipide and misoprostol groups ( @ % vs @ % , p = @ ) according to ITT analysis .", "sentence_id": 11}
+{"abstract_id": "25071901", "label": "results", "text": "In addition , the therapeutic failure rate was similar in the rebamipide and misoprostol groups ( @ % vs @ % , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25071901", "label": "results", "text": "The total severity score of the gastrointestinal symptoms was significantly lower in the rebamipide group than in the misoprostol group ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25071901", "label": "results", "text": "The amount of antacid used was significantly lower in the rebamipide group than in the misoprostol group ( p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25071901", "label": "conclusions", "text": "Rebamipide can prevent gastric ulcers when used with NSAIDs and can decrease the gastrointestinal symptoms associated with NSAID administration .", "sentence_id": 15}
+{"abstract_id": "25071901", "label": "conclusions", "text": "When the possibility of poor compliance and the potential adverse effects of misoprostol are considered , rebamipide appears to be a clinically effective and safe alternative .", "sentence_id": 16}
+{"abstract_id": "24813026", "label": "objective", "text": "The purpose of this study was to evaluate the efficacy and safety of duloxetine flexible dose in children ( @-@ years ) and adolescents ( @-@ years ) with major depressive disorder ( MDD ) .", "sentence_id": 0}
+{"abstract_id": "24813026", "label": "methods", "text": "Patients ( n = @ ) in this @ week study ( @ week acute and @ week extension treatment ) received duloxetine ( @-@mg once daily -LSB- QD -RSB- , n = @ ) , fluoxetine ( @-@mg QD , n = @ ) , or placebo ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24813026", "label": "methods", "text": "Measures included : Children 's Depression Rating Scale-Revised ( CDRS-R ) , treatment-emergent adverse events ( TEAEs ) , and Columbia-Suicide Severity Rating Scale ( C-SSRS ) .", "sentence_id": 2}
+{"abstract_id": "24813026", "label": "results", "text": "Neither active drug ( duloxetine or fluoxetine ) separated significantly ( p < @ ) from placebo on mean change from baseline to end-point ( @ weeks ) on the CDRS-R total score .", "sentence_id": 3}
+{"abstract_id": "24813026", "label": "results", "text": "There were no significant differences between the duloxetine or fluoxetine groups compared with placebo on serious AEs ( SAEs ) , total TEAEs , or discontinuation for AE during acute treatment .", "sentence_id": 4}
+{"abstract_id": "24813026", "label": "results", "text": "There were no completed suicides or deaths , and no clinically significant electrocardiogram ( ECG ) abnormalities observed during the study .", "sentence_id": 5}
+{"abstract_id": "24813026", "label": "results", "text": "One fluoxetine and one duloxetine patient experienced alanine aminotransferase ( ALT ) three or more times the upper limit of normal , which resolved during the study .", "sentence_id": 6}
+{"abstract_id": "24813026", "label": "results", "text": "A total of @ ( @ % ) duloxetine patients , @ ( @ % ) placebo patients , and @ ( @ % ) fluoxetine patients had worsening of suicidal ideation from baseline during acute treatment .", "sentence_id": 7}
+{"abstract_id": "24813026", "label": "results", "text": "Of the patients with suicidal ideation at baseline , @/@ ( @ % ) duloxetine , @/@ ( @ % ) placebo , and @/@ ( @ % ) fluoxetine had improvement in suicidal ideation at end-point during acute treatment .", "sentence_id": 8}
+{"abstract_id": "24813026", "label": "results", "text": "One duloxetine and two fluoxetine patients had treatment-emergent suicidal behavior during the @ week study .", "sentence_id": 9}
+{"abstract_id": "24813026", "label": "conclusions", "text": "Trial results were inconclusive , as neither the investigational drug ( duloxetine ) nor the active control ( fluoxetine ) separated from placebo on the CDRS-R at @ weeks .", "sentence_id": 10}
+{"abstract_id": "24813026", "label": "conclusions", "text": "No new duloxetine safety signals were identified relative to those seen in adults .", "sentence_id": 11}
+{"abstract_id": "24813026", "label": "conclusions", "text": "Clinical Trial Registry Number : NCT@ .", "sentence_id": 12}
+{"abstract_id": "25145522", "label": "background", "text": "The @ Eighth Joint National Committee panel recommendations for management of high blood pressure ( BP ) recommend a systolic BP threshold for initiation of drug therapy and a therapeutic target of < @ mm Hg in those@ years of age , a departure from prior recommendations of < @ mm Hg .", "sentence_id": 0}
+{"abstract_id": "25145522", "label": "background", "text": "However , it is not known whether this is an optimal choice , especially for the large population with coronary artery disease ( CAD ) .", "sentence_id": 1}
+{"abstract_id": "25145522", "label": "objective", "text": "This study sought to evaluate optimal BP in patients@ years of age .", "sentence_id": 2}
+{"abstract_id": "25145522", "label": "methods", "text": "Patients @ years of age or older with CAD and baseline systolic BP > @ mm Hg randomized to a treatment strategy on the basis of either atenolol/hydrochlorothiazide or verapamil-SR ( sustained release ) / trandolapril in INVEST ( INternational VErapamil SR Trandolapril STudy ) were categorized into @ groups on the basis of achieved on-treatment systolic BP : group @ , < @ mm Hg ; group @ , @ to < @ mm Hg ; and group @,@ mm Hg .", "sentence_id": 3}
+{"abstract_id": "25145522", "label": "methods", "text": "Primary outcome was first occurrence of all-cause death , nonfatal myocardial infarction ( MI ) , or nonfatal stroke .", "sentence_id": 4}
+{"abstract_id": "25145522", "label": "methods", "text": "Secondary outcomes were all-cause mortality , cardiovascular mortality , total MI , nonfatal MI , total stroke , nonfatal stroke , heart failure , or revascularization , tabulated separately .", "sentence_id": 5}
+{"abstract_id": "25145522", "label": "methods", "text": "Outcomes for each group were compared in unadjusted and multiple propensity score-adjusted models .", "sentence_id": 6}
+{"abstract_id": "25145522", "label": "results", "text": "Among @,@ patients included in this analysis with an accumulated @,@ patient-years of follow-up , @,@ ( @ % ) achieved systolic BP of < @ mm Hg ( group @ ) , @,@ ( @ % ) achieved systolic BP of @ to < @ mm Hg ( group @ ) , and @,@ ( @ % ) achieved systolic BP of@ mm Hg ( group @ ) .", "sentence_id": 7}
+{"abstract_id": "25145522", "label": "results", "text": "In unadjusted models , group @ had the lowest rates of the primary outcome ( @ % vs. @ % vs. @ % ; p < @ ) , all-cause mortality ( @ % vs. @ % vs. @ % ; p < @ ) , cardiovascular mortality ( @ % vs. @ % vs. @ % ; p < @ ) , MI ( @ % vs. @ % vs. @ % ; p < @ ) , total stroke ( @ % vs. @ % vs. @ % ; p < @ ) , and nonfatal stroke ( @ % vs @ % vs @ % ; p < @ ) compared with groups @ and @ , respectively .", "sentence_id": 8}
+{"abstract_id": "25145522", "label": "results", "text": "In multiple propensity score-adjusted models , compared with the reference group of < @ mm Hg ( group @ ) , the risk of cardiovascular mortality ( adjusted hazard ratio -LSB- HR -RSB- : @ ; @ % confidence interval -LSB- CI -RSB- : @ to @ ; p = @ ) , total stroke ( adjusted HR : @ ; @ % CI : @ to @ ; p = @ ) and nonfatal stroke ( adjusted HR : @ ; @ % CI : @ to @ ; p = @ ) was increased in the group with BP of @ to < @ mm Hg , whereas the risk of primary outcome , all-cause mortality , cardiovascular mortality , total MI , nonfatal MI , total stroke , and nonfatal stroke was increased in the group with BP@ mm Hg .", "sentence_id": 9}
+{"abstract_id": "25145522", "label": "conclusions", "text": "In hypertensive patients with CAD who are@ years of age , achieving a BP target of @ to < @mm Hg as recommended by the JNC-@ panel was associated with less benefit than the previously recommended target of < @ mm Hg .", "sentence_id": 10}
+{"abstract_id": "25991758", "label": "background", "text": "After cardiac surgery , patients receive large amounts of fluid in the Intensive Care Unit ( ICU ) .", "sentence_id": 0}
+{"abstract_id": "25991758", "label": "background", "text": "We plan to conduct a multi-centre randomised controlled trial , of a conservative fluid regime , in patients after cardiac surgery , and have reported results of a feasibility study that evaluated efficacy and safety of the proposed regime .", "sentence_id": 1}
+{"abstract_id": "25991758", "label": "methods", "text": "After ethical approval , a single-centre , prospectively randomised interventional study was undertaken .", "sentence_id": 2}
+{"abstract_id": "25991758", "label": "methods", "text": "Participants were randomised to either usual care , or to a protocolised algorithm , utilising stroke volume variation , to guide fluid administration to patients who were deemed to have inadequate cardiac output and were likely to be volume responsive .", "sentence_id": 3}
+{"abstract_id": "25991758", "label": "methods", "text": "The study protocol lasted from ICU admission to de-sedation or @ h , whichever occurred first .", "sentence_id": 4}
+{"abstract_id": "25991758", "label": "results", "text": "We randomised @ subjects over @ months .", "sentence_id": 5}
+{"abstract_id": "25991758", "label": "results", "text": "Less bolus fluid and less total overall fluid volume was administered in the intervention group ( median ( IQR ) @ ml ( @-@ ) and @ ml ( @-@ ; P < @ ) , compared with the usual care group ( @ ml ( @-@ ) and @ ml ( @-@ ; P = @ ) , from ICU admission to extubation .", "sentence_id": 6}
+{"abstract_id": "25991758", "label": "results", "text": "There was no significant difference in incidence of acute kidney injury or the average amount of fluid administered to the usual care group at the beginning compared with the end of the study .", "sentence_id": 7}
+{"abstract_id": "25991758", "label": "conclusions", "text": "It is both possible and safe to achieve a significant reduction in the amount of fluid administered to patients , allocated to a conservative fluid protocol .", "sentence_id": 8}
+{"abstract_id": "25991758", "label": "conclusions", "text": "These results suggest that a planned multi-centre study is both justified and feasible .", "sentence_id": 9}
+{"abstract_id": "25588594", "label": "objective", "text": "Dexmedetomidine can prolong the duration of local anesthetics , but the effect of retrobulbar dexmedetomidine on the potency of ropivacaine for retrobulbar block has not been investigated .", "sentence_id": 0}
+{"abstract_id": "25588594", "label": "objective", "text": "Our study was designed to determine the effect of retrobulbar dexmedetomidine on ropivacaine for retrobulbar block in children .", "sentence_id": 1}
+{"abstract_id": "25588594", "label": "methods", "text": "A group of @ children aged @-@ years scheduled for vitreoretinal surgery who received retrobulbar block were randomly assigned to @ of @ groups : group L ( retrobulbar ropivacaine ) , group LD@ ( ropivacaine plus @ g.kg-@ dexmedetomidine ) , or group LD@ ( ropivacaine plus @ g.kg-@ dexmedetomidine ) .", "sentence_id": 2}
+{"abstract_id": "25588594", "label": "methods", "text": "The minimum local anesthetic concentration ( MLAC ) was determined according to a Dixon-Massey protocol .", "sentence_id": 3}
+{"abstract_id": "25588594", "label": "methods", "text": "The primary endpoint of the study was MLAC .", "sentence_id": 4}
+{"abstract_id": "25588594", "label": "methods", "text": "Secondary outcomes were duration of postoperative analgesia , postoperative pain scores , dexmedetomidine side effects , and time to hospital discharge .", "sentence_id": 5}
+{"abstract_id": "25588594", "label": "results", "text": "The MLAC values of retrobulbar ropivacaine were @ % , @ % , and @ % in groups L , LD@ , and LD@ , respectively .", "sentence_id": 6}
+{"abstract_id": "25588594", "label": "results", "text": "The median ( interquartile range ) durations of analgesia in the postoperative period were @ ( @-@ ) , @ ( @-@ ) , and @ ( @-@ ) minutes in groups L , LD@ , and LD@ , respectively ( L vs LD@ or LD@ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25588594", "label": "results", "text": "Wake-up time was significantly increased in groups LD@ and LD@ .", "sentence_id": 8}
+{"abstract_id": "25588594", "label": "conclusions", "text": "Retrobulbar dexmedetomidine reduces the MLAC values of ropivacaine and improves postoperative analgesia in children without any neurologic side effects .", "sentence_id": 9}
+{"abstract_id": "25462898", "label": "background", "text": "Empathy improves our ability to communicate in social interactions and motivates prosocial behavior .", "sentence_id": 0}
+{"abstract_id": "25462898", "label": "background", "text": "The neuropeptides arginine vasopressin and oxytocin play key roles in socioemotional processes such as pair bonding and parental care , which suggests that they may be involved in empathic processing .", "sentence_id": 1}
+{"abstract_id": "25462898", "label": "methods", "text": "We investigated how vasopressin and oxytocin affect empathic responding in a randomized , double-blind , placebo controlled , between-subjects study design .", "sentence_id": 2}
+{"abstract_id": "25462898", "label": "methods", "text": "We also examined the moderating role of parental warmth , as reported in the early family environment , on empathic responding following vasopressin , oxytocin , or placebo administration .", "sentence_id": 3}
+{"abstract_id": "25462898", "label": "results", "text": "Among participants who reported higher levels of paternal warmth ( but not maternal warmth ) , vasopressin ( vs. placebo and oxytocin ) increased ratings of empathic concern after viewing distressing and uplifting videos .", "sentence_id": 4}
+{"abstract_id": "25462898", "label": "results", "text": "No main or interaction effects were found for individuals who received oxytocin .", "sentence_id": 5}
+{"abstract_id": "25462898", "label": "conclusions", "text": "Vasopressin has a role in enhancing empathy among individuals who received higher levels of paternal warmth .", "sentence_id": 6}
+{"abstract_id": "24840511", "label": "objective", "text": "Levels of stool fatty acid soaps and beneficial bacteria differ between formula-fed and breast-fed infants ; addition of specific formula ingredients may reduce these differences .", "sentence_id": 0}
+{"abstract_id": "24840511", "label": "objective", "text": "This study evaluated the effects of a term infant formula containing high sn-@ palmitate term infant formula ( sn-@ ) or an identical formula supplemented with oligofructose ( OF ) at @ concentrations ( sn-@ +@ g/L OF , sn-@ +@ g/L OF ) on stool composition , stool characteristics , and fecal bifidobacteria .", "sentence_id": 1}
+{"abstract_id": "24840511", "label": "methods", "text": "Healthy , term formula-fed infants @ to @ days old ( n = @ ) were randomized in a double-blind manner to receive standard formula ( control ) , sn-@ , sn-@ +@ g/L OF , or sn-@ +@ g/L OF for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24840511", "label": "methods", "text": "Human milk ( HM ) - fed infants ( n = @ ) were studied in parallel .", "sentence_id": 3}
+{"abstract_id": "24840511", "label": "methods", "text": "Stool samples were collected from all subjects at week @ for fatty acid soaps and mineral content , and from a subset at baseline and week @ for bifidobacteria .", "sentence_id": 4}
+{"abstract_id": "24840511", "label": "methods", "text": "Stool characteristics were assessed via @-day diary .", "sentence_id": 5}
+{"abstract_id": "24840511", "label": "results", "text": "The sn-@ group had @ % less stool soap palmitate ( P < @ ) and softer stools than control ( @ % more mushy soft stools , P = @ ; @ % fewer formed stools , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24840511", "label": "results", "text": "Addition of OF resulted in even fewer formed stools versus control ( @ % fewer for sn-@ +@ g/L OF , @ % fewer for sn-@ +@ g/L OF ) , with @ g/L OF more closely resembling that of HM-fed infants .", "sentence_id": 7}
+{"abstract_id": "24840511", "label": "results", "text": "Both sn-@ ( P < @ ) and sn-@ with OF groups ( P < @ ) had significantly higher fecal bifidobacteria concentrations than control at week @ , not differing from HM-fed infants .", "sentence_id": 8}
+{"abstract_id": "24840511", "label": "conclusions", "text": "High sn-@-palmitate formulas led to reduced stool soaps , softer stools , and increased bifidobacteria , whereas addition of OF further improved stool consistency .", "sentence_id": 9}
+{"abstract_id": "24840511", "label": "conclusions", "text": "Those modifications brought outcomes in formula-fed infants closer to that in HM-fed infants .", "sentence_id": 10}
+{"abstract_id": "24560332", "label": "background", "text": "Targeting the epidermal-growth-factor-receptor ( EGFR ) in non-small cell lung cancer ( NSCLC ) is an established treatment option with less toxicity compared to conventional chemotherapy .", "sentence_id": 0}
+{"abstract_id": "24560332", "label": "background", "text": "This study was undertaken to determine whether Erlotinib is non-inferior compared to chemotherapy as a first-line therapy in unselected elderly patients .", "sentence_id": 1}
+{"abstract_id": "24560332", "label": "methods", "text": "Patients @ years with untreated , metastatic NSCLC were randomized to Erlotinib ( E ) , @ mg/day or Carboplatin ( AUC@ ) plus Vinorelbine ( @mg/m ( @ ) on days @ and @ ) every three weeks ( CV ) .", "sentence_id": 2}
+{"abstract_id": "24560332", "label": "methods", "text": "Primary endpoint was progression-free survival ( PFS ) .", "sentence_id": 3}
+{"abstract_id": "24560332", "label": "methods", "text": "After progression , crossover was strongly recommended .", "sentence_id": 4}
+{"abstract_id": "24560332", "label": "methods", "text": "Secondary endpoints were duration of response , @-year survival , overall survival ( OS ) , response rate ( RR ) , quality of life ( FACT-L ) , assessment of comorbidities by simplified comorbidity score ( SCS ) and Charlsons ' comorbidity score , safety and assessment of molecular markers .", "sentence_id": 5}
+{"abstract_id": "24560332", "label": "results", "text": "Between June @ and August @ @ pts were randomized to E ( @ ) and CV ( @ ) .", "sentence_id": 6}
+{"abstract_id": "24560332", "label": "results", "text": "PFS was significantly inferior with E ( median PFS @ versus @ months -LSB- HR @ , @ % CI @-@ @ , p : @ -RSB- ) as well as RR ( @ % v @ % , p : @ ) .", "sentence_id": 7}
+{"abstract_id": "24560332", "label": "results", "text": "No significant difference in OS appeared ( median E : @ months versus CV : @ months , HR : @ -LSB- @ % CI @-@ @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "24560332", "label": "results", "text": "In never smokers PFS ( median PFS : @ v @ m , E v CV , HR @ , @ % CI @-@ @ ) and OS ( median : @ versus @ months , HR @ -LSB- @ % CI @-@ @ -RSB- ) were comparable .", "sentence_id": 9}
+{"abstract_id": "24560332", "label": "results", "text": "More skin toxicity and diarrhea was seen with E compared to more myelotoxicity , neurotoxicity and constipation with CV .", "sentence_id": 10}
+{"abstract_id": "24560332", "label": "results", "text": "Less severe adverse events were observed with E ( @ v @ , E v CV ) .", "sentence_id": 11}
+{"abstract_id": "24560332", "label": "conclusions", "text": "CV had an increased efficacy compared with E in an unselected population of elderly patients with advanced NSCLC .", "sentence_id": 12}
+{"abstract_id": "24508103", "label": "background", "text": "In the BRIM-@ trial , vemurafenib was associated with risk reduction versus dacarbazine of both death and progression in patients with advanced BRAF ( V@ ) mutation-positive melanoma .", "sentence_id": 0}
+{"abstract_id": "24508103", "label": "background", "text": "We present an extended follow-up analysis of the total population and in the BRAF ( V@E ) and BRAF ( V@K ) mutation subgroups .", "sentence_id": 1}
+{"abstract_id": "24508103", "label": "methods", "text": "Patients older than @ years , with treatment-naive metastatic melanoma and whose tumour tissue was positive for BRAF ( V@ ) mutations were eligible .", "sentence_id": 2}
+{"abstract_id": "24508103", "label": "methods", "text": "Patients also had to have a life expectancy of at least @ months , an Eastern Cooperative Oncology Group ( ECOG ) performance status of @ or @ , and adequate haematological , hepatic , and renal function .", "sentence_id": 3}
+{"abstract_id": "24508103", "label": "methods", "text": "Patients were randomly assigned by interactive voice recognition system to receive either vemurafenib ( @ mg orally twice daily ) or dacarbazine ( @ mg/m ( @ ) of body surface area intravenously every @ weeks ) .", "sentence_id": 4}
+{"abstract_id": "24508103", "label": "methods", "text": "Coprimary endpoints were overall survival and progression-free survival , analysed in the intention-to-treat population ( n = @ ) , with data censored at crossover .", "sentence_id": 5}
+{"abstract_id": "24508103", "label": "methods", "text": "A sensitivity analysis was done .", "sentence_id": 6}
+{"abstract_id": "24508103", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 7}
+{"abstract_id": "24508103", "label": "results", "text": "@ eligible patients were enrolled from @ centres in @ countries between Jan @ , @ , and Dec @ , @ patients were randomly assigned to receive vemurafenib and @ to receive dacarbazine .", "sentence_id": 8}
+{"abstract_id": "24508103", "label": "results", "text": "Median follow-up was @ months ( IQR @-@ ) on vemurafenib and @ months ( @-@ ) on dacarbazine .", "sentence_id": 9}
+{"abstract_id": "24508103", "label": "results", "text": "@ ( @ % ) of the @ patients initially randomly assigned to dacarbazine crossed over from dacarbazine to vemurafenib .", "sentence_id": 10}
+{"abstract_id": "24508103", "label": "results", "text": "Median overall survival was significantly longer in the vemurafenib group than in the dacarbazine group ( @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; hazard ratio -LSB- HR -RSB- @ -LSB- @ % CI @-@ -RSB- ; p = @ ) , as was median progression-free survival ( @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; HR @ -LSB- @ % CI @-@ -RSB- ; p < @ ) .", "sentence_id": 11}
+{"abstract_id": "24508103", "label": "results", "text": "For the @ ( @ % ) patients with BRAF ( V@E ) disease , median overall survival in the vemurafenib group was @ months ( @ % CI @-@ ) compared with @ months ( @-@ ) in the dacarbazine group ( HR @ -LSB- @ % CI @-@ -RSB- ; p = @ ) ; median progression-free survival was @ months ( @ % CI @-@ ) and @ months ( @-@ ) , respectively ( HR @ -LSB- @ % CI @-@ -RSB- ; p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24508103", "label": "results", "text": "For the @ ( @ % ) patients with BRAF ( V@K ) disease , median overall survival in the vemurafenib group was @ months ( @ % CI @-not estimable ) compared with @ months ( @-@ ) in the dacarbazine group ( HR @ -LSB- @ % CI @-@ -RSB- ; p = @ ) ; median progression-free survival was @ months ( @ % CI @-@ ) and @ months ( @-@ ) , respectively ( HR @ -LSB- @ % CI @-@ -RSB- ; p < @ ) .", "sentence_id": 13}
+{"abstract_id": "24508103", "label": "results", "text": "The most frequent grade @-@ events were cutaneous squamous-cell carcinoma ( @ -LSB- @ % -RSB- of @ patients ) and keratoacanthomas ( @ -LSB- @ % -RSB- ) , rash ( @ -LSB- @ % -RSB- ) , and abnormal liver function tests ( @ -LSB- @ % -RSB- ) in the vemurafenib group and neutropenia ( @ -LSB- @ % -RSB- of @ patients ) in the dacarbazine group .", "sentence_id": 14}
+{"abstract_id": "24508103", "label": "results", "text": "Eight ( @ % ) patients in the vemurafenib group and seven ( @ % ) in the dacarbazine group had grade @ events .", "sentence_id": 15}
+{"abstract_id": "24508103", "label": "conclusions", "text": "Inhibition of BRAF with vemurafenib improves survival in patients with the most common BRAF ( V@E ) mutation and in patients with the less common BRAF ( V@K ) mutation .", "sentence_id": 16}
+{"abstract_id": "24773418", "label": "objective", "text": "This study investigated the effect of exposure to television food advertising on accessibility of food-related cognitions and motivation to eat .", "sentence_id": 0}
+{"abstract_id": "24773418", "label": "methods", "text": "We initially developed a word stem completion task to measure accessibility of food-related cognitions .", "sentence_id": 1}
+{"abstract_id": "24773418", "label": "methods", "text": "In two subsequent experiments , @ female undergraduate students ( Experiment @ ) and @ overweight or obese community-dwelling women ( Experiment @ ) viewed a series of television commercials advertising either food or non-food products .", "sentence_id": 2}
+{"abstract_id": "24773418", "label": "methods", "text": "They then completed the word stem task and also rated their desire to eat .", "sentence_id": 3}
+{"abstract_id": "24773418", "label": "results", "text": "Exposure to televised food advertisements led to the completion of word stems with more food - and eating-related words in both experiments .", "sentence_id": 4}
+{"abstract_id": "24773418", "label": "results", "text": "It also increased self-reported desire to eat , but only for overweight and obese individuals ( Experiment @ ) .", "sentence_id": 5}
+{"abstract_id": "24773418", "label": "results", "text": "In both samples , there was a positive association between accessibility of food-related cognitions and reported desire to eat , following priming with television food advertisements .", "sentence_id": 6}
+{"abstract_id": "24773418", "label": "conclusions", "text": "We conclude that an increased activation of food-related cognitions may provide a mechanism for the link between food advertising and consumption .", "sentence_id": 7}
+{"abstract_id": "24773418", "label": "conclusions", "text": "This has implications for tackling pathological ( over ) eating .", "sentence_id": 8}
+{"abstract_id": "24916838", "label": "background", "text": "The study aims to determine whether the route of insulin administration influences glycaemic variability and inflammatory or neurohormonal markers in patients with type @ diabetes and congestive heart failure ( CHF ) exacerbation .", "sentence_id": 0}
+{"abstract_id": "24916838", "label": "methods", "text": "Patients ( n = @ ) were randomized to intravenous ( IV ) insulin ( duration @ h ) or subcutaneous ( SQ ) insulin .", "sentence_id": 1}
+{"abstract_id": "24916838", "label": "methods", "text": "Inflammatory cytokines and markers of lipid oxidation , high-frequency heart rate variability ( n = @ ) and cardiac impedance ( pre-ejection period , n = @ ) were used to estimate parasympathetic and sympathetic tone in patients with valid cardiac data .", "sentence_id": 2}
+{"abstract_id": "24916838", "label": "methods", "text": "Glycaemic variability was measured using a continuous glucose monitor .", "sentence_id": 3}
+{"abstract_id": "24916838", "label": "results", "text": "Mean glucose was lower ( @ vs @ mmol/L , p = @ ) , coefficient of variation was higher ( p = @ ) and glycaemic lability index was similar on day @ in the IV group compared with the SQ group , but groups were similar by day @ .", "sentence_id": 4}
+{"abstract_id": "24916838", "label": "results", "text": "The IV group had more confirmed hypoglycaemia ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24916838", "label": "results", "text": "There were no differences in hospital readmission or hospital length of stay between groups .", "sentence_id": 6}
+{"abstract_id": "24916838", "label": "results", "text": "There were no differences in CHF biomarkers , heart rate variability or pre-ejection period between groups .", "sentence_id": 7}
+{"abstract_id": "24916838", "label": "results", "text": "Increasing log glycaemic lability index was associated with lower on-treatment pre-ejection period ( p = @ ) while increasing coefficient of variation was associated with increasing brain natriuretic peptide ( p = @ ) and paroxonase-@ ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24916838", "label": "results", "text": "Other univariable analyses were not significant .", "sentence_id": 9}
+{"abstract_id": "24916838", "label": "conclusions", "text": "There were modest , transient differences in glucose control between IV and SQ insulin in hospitalized CHF patients .", "sentence_id": 10}
+{"abstract_id": "24916838", "label": "conclusions", "text": "However , the analyses do not support a link between insulin route and inflammatory markers or autonomic tone .", "sentence_id": 11}
+{"abstract_id": "24916838", "label": "conclusions", "text": "Further study is needed to assess outcomes in hospitalized CHF patients .", "sentence_id": 12}
+{"abstract_id": "24607003", "label": "background", "text": "New vaccines containing highly conserved Streptococcus pneumoniae proteins such as pneumolysin toxoid ( dPly ) and histidine-triad protein D ( PhtD ) are being developed to provide broader protection against pneumococcal disease .", "sentence_id": 0}
+{"abstract_id": "24607003", "label": "background", "text": "This study evaluated the safety , reactogenicity and immunogenicity of different pneumococcal protein-containing formulations in adults .", "sentence_id": 1}
+{"abstract_id": "24607003", "label": "methods", "text": "In a phase I double-blind study ( www.clinicaltrials.gov : NCT@ ) , healthy adults ( @-@ years ) were randomized ( @:@:@:@:@:@:@ ) to receive two doses of one of six investigational vaccine formulations @ months apart , or a single dose of the control @-valent pneumococcal polysaccharide vaccine ( @PPV ; Pneumovax@ , Sanofi Pasteur MSD ) followed by placebo .", "sentence_id": 2}
+{"abstract_id": "24607003", "label": "methods", "text": "The investigational formulations contained dPly alone ( @ or @ g ) , or both dPly and PhtD ( @ or @ g each ) alone or combined with the polysaccharide conjugates of the @-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine ( PHiD-CV ; Synflorix , GlaxoSmithKline Vaccines ) .", "sentence_id": 3}
+{"abstract_id": "24607003", "label": "methods", "text": "Two groups primed with a formulation containing dPly and PhtD ( @ or @ g each ) continued to the follow-up phase II study ( NCT@ ) , in which they received a booster dose at @-@ months after primary vaccination .", "sentence_id": 4}
+{"abstract_id": "24607003", "label": "results", "text": "Of @ enrolled and vaccinated adults , @ completed the primary immunization and @ adults received a booster dose .", "sentence_id": 5}
+{"abstract_id": "24607003", "label": "results", "text": "During primary and booster vaccination , for any formulation , @ % of doses were followed by grade @ solicited local or general adverse events .", "sentence_id": 6}
+{"abstract_id": "24607003", "label": "results", "text": "No fever > @ C ( oral temperature ) was reported .", "sentence_id": 7}
+{"abstract_id": "24607003", "label": "results", "text": "Unsolicited adverse events considered causally related to vaccination were reported following @ % of investigational vaccine doses .", "sentence_id": 8}
+{"abstract_id": "24607003", "label": "results", "text": "No serious adverse events were reported for adults receiving investigational vaccine formulations .", "sentence_id": 9}
+{"abstract_id": "24607003", "label": "results", "text": "Formulations containing dPly with or without PhtD were immunogenic for these antigens ; polysaccharide conjugate-containing formulations were also immunogenic for those @ polysaccharides .", "sentence_id": 10}
+{"abstract_id": "24607003", "label": "conclusions", "text": "Investigational vaccine formulations containing dPly and PhtD were well tolerated and immunogenic when administered to healthy adults as standalone protein vaccine or combined with PHiD-CV conjugates .", "sentence_id": 11}
+{"abstract_id": "25552616", "label": "background", "text": "Early identification ( EI ) and brief interventions ( BIs ) for risky drinkers are effective tools in primary care .", "sentence_id": 0}
+{"abstract_id": "25552616", "label": "background", "text": "Lack of time in daily practice has been identified as one of the main barriers to implementation of BI .", "sentence_id": 1}
+{"abstract_id": "25552616", "label": "background", "text": "There is growing evidence that facilitated access by primary healthcare professionals ( PHCPs ) to a web-based BI can be a time-saving alternative to standard face-to-face BIs , but there is as yet no evidence about the effectiveness of this approach relative to conventional BI .", "sentence_id": 2}
+{"abstract_id": "25552616", "label": "background", "text": "The main aim of this study is to test non-inferiority of facilitation to a web-based BI for risky drinkers delivered by PHCP against face-to-face BI .", "sentence_id": 3}
+{"abstract_id": "25552616", "label": "methods", "text": "A randomised controlled non-inferiority trial comparing both interventions will be performed in primary care health centres in Catalonia , Spain .", "sentence_id": 4}
+{"abstract_id": "25552616", "label": "methods", "text": "Unselected adult patients attending participating centres will be given a leaflet inviting them to log on to a website to complete the Alcohol Use Disorders Identification Test ( AUDIT-C ) alcohol screening questionnaire .", "sentence_id": 5}
+{"abstract_id": "25552616", "label": "methods", "text": "Participants with positive results will be requested online to complete a trial module including consent , baseline assessment and randomisation to either face-to-face BI by the practitioner or BI via the alcohol reduction website .", "sentence_id": 6}
+{"abstract_id": "25552616", "label": "methods", "text": "Follow-up assessment of risky drinking will be undertaken online at @ months and @ year using the full AUDIT and D@-EQD@ scale .", "sentence_id": 7}
+{"abstract_id": "25552616", "label": "methods", "text": "Proportions of risky drinkers in each group will be calculated and non-inferiority assessed against a specified margin of @ % .", "sentence_id": 8}
+{"abstract_id": "25552616", "label": "methods", "text": "Assuming reduction of @ % of risky drinkers receiving standard intervention , @ patients will be required to give @ % power to reject the null hypothesis .", "sentence_id": 9}
+{"abstract_id": "24941010", "label": "objective", "text": "The hyperglycemic response to surgery may be a risk factor for cognitive dysfunction .", "sentence_id": 0}
+{"abstract_id": "24941010", "label": "objective", "text": "We hypothesize that strict maintenance of normoglycemia during cardiac surgery preserves postoperative cognitive function .", "sentence_id": 1}
+{"abstract_id": "24941010", "label": "methods", "text": "As part of a larger randomized , single-blind , interventional efficacy study on the effects of hyperinsulinemic glucose control in cardiac surgery ( NCT@ ) , consenting patients were randomly assigned to receive combined administration of insulin and glucose , titrated to preserve normoglycemia ( @-@ @ mmol L ( -@ ) ; experimental group ) , or standard metabolic care ( blood glucose @-@ mmol L ( -@ ) ; control group ) , during open heart surgery .", "sentence_id": 2}
+{"abstract_id": "24941010", "label": "methods", "text": "The patients ' cognitive function was assessed during three home visits , approximately two weeks before the operation , and two months and seven months after surgery .", "sentence_id": 3}
+{"abstract_id": "24941010", "label": "methods", "text": "The following tests were performed : Rey Auditory Verbal Learning Task ( RAVLT for verbal learning and memory ) , Digit Span Task ( working memory ) , Trail Making A & B ( visuomotor tracking and attention ) , and the Word Pair Task ( implicit memory ) .", "sentence_id": 4}
+{"abstract_id": "24941010", "label": "methods", "text": "Questionnaires measuring specific traits known to affect cognitive performance , such as self-esteem , depression , chronic stress and social support , were also administered .", "sentence_id": 5}
+{"abstract_id": "24941010", "label": "methods", "text": "The primary outcome was to assess the effect of hyperinsulinemic-normoglycemic clamp therapy versus standard therapy on specific cognitive parameters in patients receiving normoglycemic clamp , or standard metabolic care .", "sentence_id": 6}
+{"abstract_id": "24941010", "label": "results", "text": "Twenty-six patients completed the study with @ patients in the normoglycemia and @ patients in the control group .", "sentence_id": 7}
+{"abstract_id": "24941010", "label": "results", "text": "Multiple analysis of covariance ( MANCOVA ) for the RAVLT showed a significant effect for the interaction of group by visit ( F = @ , p = @ ) , and group by visit by recall ( F = @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24941010", "label": "results", "text": "The differences occurred at the second and third visit .", "sentence_id": 9}
+{"abstract_id": "24941010", "label": "results", "text": "MANCOVA for the digit span task , trail making and word pair association test showed no significant effect .", "sentence_id": 10}
+{"abstract_id": "24941010", "label": "conclusions", "text": "Preserving intraoperative normoglycemia by intravenous insulin and glucose may prevent the impairment of memory function , both short and long-term , after cardiac surgery .", "sentence_id": 11}
+{"abstract_id": "25935830", "label": "background", "text": "Cardiovascular disease and cancer are leading causes of mortality for people with a history of alcohol or other substance use disorders .", "sentence_id": 0}
+{"abstract_id": "25935830", "label": "background", "text": "These chronic diseases share the same four primary behavioural risk factors i.e. excessive alcohol use , smoking , low intake of fruit and vegetables and physical inactivity .", "sentence_id": 1}
+{"abstract_id": "25935830", "label": "background", "text": "In addition to addressing problematic alcohol use , there is the potential for substance abuse treatment services to also address these other behaviours .", "sentence_id": 2}
+{"abstract_id": "25935830", "label": "background", "text": "Healthy Recovery is an @-session group-based intervention that targets these multiple behavioural health risk factors and was developed specifically for people attending substance abuse treatment .", "sentence_id": 3}
+{"abstract_id": "25935830", "label": "background", "text": "This protocol describes a Cancer Institute NSW funded study that assesses the effectiveness of delivering Healthy Recovery for people who are attending residential alcohol and other substance abuse treatment .", "sentence_id": 4}
+{"abstract_id": "25935830", "label": "methods", "text": "The study uses a stepped wedge randomised controlled design , where randomisation occurs at the service level .", "sentence_id": 5}
+{"abstract_id": "25935830", "label": "methods", "text": "Participants will be recruited from residential rehabilitation programs provided by The Australian Salvation Army .", "sentence_id": 6}
+{"abstract_id": "25935830", "label": "methods", "text": "All participants who ( @ ) currently smoke tobacco and ( @ ) are expected to be in the residential program for the duration of the @-week intervention will be asked to participate in the study .", "sentence_id": 7}
+{"abstract_id": "25935830", "label": "methods", "text": "Those participants residing at the facilities assigned to the treatment condition will complete Healthy Recovery .", "sentence_id": 8}
+{"abstract_id": "25935830", "label": "methods", "text": "The intervention is manual guided and will be delivered over a @-week period , with participants attending @ group sessions .", "sentence_id": 9}
+{"abstract_id": "25935830", "label": "methods", "text": "All participants will continue to complete The Salvation Army residential program , a predominantly @-step based , modified therapeutic community .", "sentence_id": 10}
+{"abstract_id": "25935830", "label": "methods", "text": "Participants in the control condition will complete treatment as usual .", "sentence_id": 11}
+{"abstract_id": "25935830", "label": "methods", "text": "Research staff blind to treatment allocation will complete the primary and secondary outcome assessments at baseline and then at weeks @ , @ and @ weeks post intervention .", "sentence_id": 12}
+{"abstract_id": "25935830", "label": "conclusions", "text": "This study will provide comprehensive data on the effect of delivering a healthy lifestyle intervention ( i.e. Healthy Recovery ) within a residential substance abuse setting .", "sentence_id": 13}
+{"abstract_id": "25935830", "label": "conclusions", "text": "If shown to be effective , this intervention can be disseminated within other residential substance abuse programs .", "sentence_id": 14}
+{"abstract_id": "25068412", "label": "objective", "text": "Appropriate pain management may positively affect outcome following hip fractures .", "sentence_id": 0}
+{"abstract_id": "25068412", "label": "objective", "text": "Positioning patients for spinal anesthesia ( SA ) can be extremely painful .", "sentence_id": 1}
+{"abstract_id": "25068412", "label": "objective", "text": "Peripheral nerve blockades are gaining popularity in this setting .", "sentence_id": 2}
+{"abstract_id": "25068412", "label": "objective", "text": "This prospective , randomized study compares the efficacy of fascia iliaca compartment block ( FICB ) to intravenous ( IV ) fentanyl for positioning hip fracture patients for SA .", "sentence_id": 3}
+{"abstract_id": "25068412", "label": "methods", "text": "Forty-one patients scheduled for hip fracture surgery were randomized to receive a bolus dose of IV fentanyl ( IVFE ) @ g/kg ( IVFE group ) or an FICB using @ mL ropivacaine @ % ( FICB group ) @ or @ minutes before positioning for SA , respectively .", "sentence_id": 4}
+{"abstract_id": "25068412", "label": "methods", "text": "Numeric rating pain scale scores before and following the analgesic intervention , time needed and quality of patient position for SA performance , postoperative analgesia in terms of time to first IV morphine dose demand and morphine consumption during the first @ hours , and patient satisfaction were documented .", "sentence_id": 5}
+{"abstract_id": "25068412", "label": "results", "text": "Compared with the IVFE group , the FICB group showed significantly lower numeric rating pain scale scores in all instances following the analgesic intervention ( P < @ ) , shorter spinal performance time ( P = @ ) , and better quality of position ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25068412", "label": "results", "text": "Postoperative morphine consumption was lower ( P = @ ) , the time to first dose demand was longer ( P = @ ) , and patient satisfaction rates were higher ( P < @ ) in the FICB group .", "sentence_id": 7}
+{"abstract_id": "25068412", "label": "conclusions", "text": "Performing an FICB before positioning for SA provides superior pain management compared with IVFE administration , facilitates spinal performance , and yields satisfactory postoperative analgesia and wide patient acceptance , hence improving overall quality and efficiency of care .", "sentence_id": 8}
+{"abstract_id": "24837000", "label": "objective", "text": "To determine the psychometric properties of an observational scale of anxiety .", "sentence_id": 0}
+{"abstract_id": "24837000", "label": "methods", "text": "A cross-sectional and longitudinal survey with stroke survivor-carer dyads .", "sentence_id": 1}
+{"abstract_id": "24837000", "label": "methods", "text": "Eighty-nine dyads recruited in community stroke groups completed : a demographic questionnaire ; the Behavioural Outcomes of Anxiety scale ( BOA ) , survivor-rated ( survivor BOA ) and carer-rated ( carer BOA ) versions ; the anxiety scale of the Hospital Anxiety and Depression Scales ( HADS-A ) , also in carer and survivor versions .", "sentence_id": 2}
+{"abstract_id": "24837000", "label": "methods", "text": "Twenty-seven survivors and carers repeated the BOA after @ week .", "sentence_id": 3}
+{"abstract_id": "24837000", "label": "results", "text": "Correlations between the carer BOA and the survivor HADS-A ( r = @ , p < @ ) and the survivor BOA ( r = @ , p < @ ) demonstrated construct validity .", "sentence_id": 4}
+{"abstract_id": "24837000", "label": "results", "text": "Cronbach 's alpha for the carer BOA was @ ; item statistics did not identify any items for exclusion .", "sentence_id": 5}
+{"abstract_id": "24837000", "label": "results", "text": "The test-retest coefficient at @ week was @ .", "sentence_id": 6}
+{"abstract_id": "24837000", "label": "results", "text": "Receiver operating characteristic analysis against the survivor HADS-A and BOA produced areas under the curve of @ and @ , respectively .", "sentence_id": 7}
+{"abstract_id": "24837000", "label": "results", "text": "At a cut-off score of @/@ sensitivity and specificity against the HADS-A were @ and @ , respectively , and @ and @ against the survivor BOA .", "sentence_id": 8}
+{"abstract_id": "24837000", "label": "results", "text": "The impact of stroke on memory was associated with elevated anxiety .", "sentence_id": 9}
+{"abstract_id": "24837000", "label": "results", "text": "Scores for both BOA versions were independent of demographic variables .", "sentence_id": 10}
+{"abstract_id": "24837000", "label": "conclusions", "text": "The carer BOA has acceptable psychometric properties and is independent of survivor demographic variables such as age .", "sentence_id": 11}
+{"abstract_id": "24837000", "label": "conclusions", "text": "It identifies self-reported cases with acceptable sensitivity and specificity .", "sentence_id": 12}
+{"abstract_id": "24837000", "label": "conclusions", "text": "It has potential for use with persons unable to self-report anxiety .", "sentence_id": 13}
+{"abstract_id": "24837000", "label": "conclusions", "text": "Further validation is recommended , but its continuing use is supported .", "sentence_id": 14}
+{"abstract_id": "24758417", "label": "objective", "text": "Ginseng root and its derivatives remain atop the most widely used medicinal herbs in cardiovascular disease , despite inadequate substantiation of efficacy .", "sentence_id": 0}
+{"abstract_id": "24758417", "label": "objective", "text": "We previously reported the potential of Korean red ginseng ( KRG ) to affect vascular tone by decreasing arterial wave reflection via an unknown mechanism .", "sentence_id": 1}
+{"abstract_id": "24758417", "label": "objective", "text": "Given the preclinical link between ginseng intake and vasoactivity related to nitric oxide ( NO ) production , we sought to directly evaluate the effects of KRG root and its major root components , on an established noninvasive measure of endothelial function .", "sentence_id": 2}
+{"abstract_id": "24758417", "label": "methods", "text": "In an acute , randomized , placebo-controlled , double-blind , crossover design , @ healthy participants ( @M :@ F , age :@ y , BMI : @ kg@kg/m ( @ ) , systolicBP/diastolicBP : @/@mmHg ) on four occasions were administered : KRG root ( @g ) , KRG ginsenosides extract , KRG polysaccharides extract , and cornstarch control .", "sentence_id": 3}
+{"abstract_id": "24758417", "label": "methods", "text": "Extracted fractions were delivered at doses bioequivalent to those found in @g of KRG .", "sentence_id": 4}
+{"abstract_id": "24758417", "label": "methods", "text": "Flow-mediated vasodilatation ( FMD ) assessment , preceding a brachial blood pressure measurement , was performed at baseline and at @ and @ min posttreatment to assess endothelial function .", "sentence_id": 5}
+{"abstract_id": "24758417", "label": "results", "text": "KRG significantly improved FMD posttreatment .", "sentence_id": 6}
+{"abstract_id": "24758417", "label": "results", "text": "Maximal vasodilatation of @ % occurred at @min compared with control ( -@ % , P = @ for all comparisons ) .", "sentence_id": 7}
+{"abstract_id": "24758417", "label": "results", "text": "The ginsenoside extract produced a comparable response ( @ % ) , but not the polysaccharide fraction ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24758417", "label": "results", "text": "Brachial blood pressure remained unchanged for all treatments ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24758417", "label": "conclusions", "text": "KRG acutely improved endothelial function in healthy individuals , which appears to be attributable to its ginsenoside containing fraction .", "sentence_id": 10}
+{"abstract_id": "24758417", "label": "conclusions", "text": "Our data confirm preclinical data and support the potential for these compounds as targets for therapeutic strategies in disorders involving endothelial dysfunction .", "sentence_id": 11}
+{"abstract_id": "25012707", "label": "objective", "text": "The Micropuncture @-gauge needle may reduce complications related to vessel trauma from inadvertent venous or posterior arterial wall puncture .", "sentence_id": 0}
+{"abstract_id": "25012707", "label": "methods", "text": "This was a single-center , multiple-user trial .", "sentence_id": 1}
+{"abstract_id": "25012707", "label": "methods", "text": "Four hundred and two patients undergoing possible or definite percutaneous coronary intervention ( PCI ) were randomized @:@ to an @-gauge versus a @-gauge needle .", "sentence_id": 2}
+{"abstract_id": "25012707", "label": "methods", "text": "Patients and personnel pulling the sheaths and performing the follow-up were blinded .", "sentence_id": 3}
+{"abstract_id": "25012707", "label": "methods", "text": "The primary end point was a composite of access bleeding .", "sentence_id": 4}
+{"abstract_id": "25012707", "label": "methods", "text": "Events were tabulated following sheath removal , @ h after the procedure and at the follow-up ( at @-@ weeks ) .", "sentence_id": 5}
+{"abstract_id": "25012707", "label": "methods", "text": "End points were blindly adjudicated .", "sentence_id": 6}
+{"abstract_id": "25012707", "label": "results", "text": "The event rate overall was @ % and did not differ significantly between groups , although the @-gauge needle was found to reduce events by more than one third .", "sentence_id": 7}
+{"abstract_id": "25012707", "label": "results", "text": "An exploratory subgroup analysis of prespecified variables indicated that : patients who did not undergo PCI or elective procedures , female patients and those with a final sheath size of @ Fr all had a significant or near-significant reduction of complications with Micropuncture .", "sentence_id": 8}
+{"abstract_id": "25012707", "label": "conclusions", "text": "Although no significant differences between the use of the @ - and @-gauge needles were observed , there was a @-@ % reduction with Micropuncture in several subgroups .", "sentence_id": 9}
+{"abstract_id": "25012707", "label": "conclusions", "text": "The study was terminated prematurely .", "sentence_id": 10}
+{"abstract_id": "25012707", "label": "conclusions", "text": "Access site complications may be reduced by the use of the @-gauge needle , particularly when the risk of bleeding is not high .", "sentence_id": 11}
+{"abstract_id": "25012707", "label": "conclusions", "text": "Further multicenter data will be required to confirm these hypothesis-generating observations .", "sentence_id": 12}
+{"abstract_id": "24827405", "label": "background", "text": "No randomized comparative trials have presented long-term outcomes for laparoscopic sleeve gastrectomy ( LSG ) and laparoscopic Roux-en-Y gastric bypass ( LRYGB ) .", "sentence_id": 0}
+{"abstract_id": "24827405", "label": "background", "text": "The present study was designed to compare the efficacy and safety of these two procedures .", "sentence_id": 1}
+{"abstract_id": "24827405", "label": "methods", "text": "From January @ to July @ , @ eligible patients were randomly assigned to LSG or LRYGB .", "sentence_id": 2}
+{"abstract_id": "24827405", "label": "methods", "text": "During the @-year follow-up , we compared morbidity rate , body mass index ( BMI ) , percent of excess weight loss ( % EWL ) , Moorehead-Ardelt ( M-A ) II quality of life , and resolution or improvement rate of obesity-related comorbidities between the groups .", "sentence_id": 3}
+{"abstract_id": "24827405", "label": "results", "text": "Both groups were matched with respect to age , gender , and BMI .", "sentence_id": 4}
+{"abstract_id": "24827405", "label": "results", "text": "Slightly more major complications were observed in patients undergoing LRYGB ( P > @ ) .", "sentence_id": 5}
+{"abstract_id": "24827405", "label": "results", "text": "Weight loss was significantly better with LRYGB except during the first postoperative year .", "sentence_id": 6}
+{"abstract_id": "24827405", "label": "results", "text": "At @ years , % EWL for LSG and LRYGB was @ % and @ % ( P = @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "24827405", "label": "results", "text": "No statistical difference was observed in quality of life between the groups at all intervals ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24827405", "label": "results", "text": "At the last follow-up , most comorbidities in both groups were resolved or improved , with no difference between the groups ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24827405", "label": "conclusions", "text": "LRYGB and LSG are equally safe and effective in quality of life and improvement or resolution of comorbidities , and LRYGB possesses the superiority in terms of weight loss .", "sentence_id": 10}
+{"abstract_id": "24827405", "label": "conclusions", "text": "Further studies are needed to evaluate micronutrient deficiencies of these procedures .", "sentence_id": 11}
+{"abstract_id": "24676435", "label": "objective", "text": "To assess the effect of aerobic exercise on the cognition and functional capacity in Alzheimer 's disease ( AD ) patients .", "sentence_id": 0}
+{"abstract_id": "24676435", "label": "methods", "text": "Elderly ( n = @ ) with mild dementia ( NINCDS-ADRDA/CDR@ ) were randomly assigned to an exercise group ( EG ) on a treadmill ( @ minutes , twice a week and moderate intensity of @ % VOmax ) and control group ( GC ) @ patients .", "sentence_id": 1}
+{"abstract_id": "24676435", "label": "methods", "text": "The primary outcome measure was the cognitive function using Cambridge Cognitive Examination ( CAMCOG ) .", "sentence_id": 2}
+{"abstract_id": "24676435", "label": "methods", "text": "Specifics instruments were also applied to evaluate executive function , memory , attention and concentration , cognitive flexibility , inhibitory control and functional capacity .", "sentence_id": 3}
+{"abstract_id": "24676435", "label": "results", "text": "After @ weeks , the EG showed improvement in cognition CAMCOG whereas the CG declined .", "sentence_id": 4}
+{"abstract_id": "24676435", "label": "results", "text": "Compared to the CG , the EG presented significant improvement on the functional capacity .", "sentence_id": 5}
+{"abstract_id": "24676435", "label": "results", "text": "The analysis of the effect size has shown a favorable response to the physical exercise in all dependent variables .", "sentence_id": 6}
+{"abstract_id": "24676435", "label": "conclusions", "text": "Walking on treadmill may be recommended as an augmentation treatment for patients with AD .", "sentence_id": 7}
+{"abstract_id": "24524600", "label": "objective", "text": "To evaluate the effects and clinical prognosis of out-patient department-based smoking cessation services for coronary heart disease ( CHD ) patients .", "sentence_id": 0}
+{"abstract_id": "24524600", "label": "methods", "text": "A total of @ smoking patients diagnosed with coronary heart disease in our cardiovascular department were randomly divided into the intensive smoking cessation clinic follow-up group ( intervention group , patients were informed on the importance and methods to quit smoking at the first visit and reminded for that at months interval for @ months , n = @ ) and the conventional treatment group ( control group , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24524600", "label": "methods", "text": "After @ months , the smoking status , cardiovascular event rates , drug usage , out-patient medical costs and quality of life were compared between the two groups .", "sentence_id": 2}
+{"abstract_id": "24524600", "label": "results", "text": "Age , gender , concomitant diseases , drug usage were similar between the two groups at baseline ( all P > @ ) .", "sentence_id": 3}
+{"abstract_id": "24524600", "label": "results", "text": "After @ months , smoking quit rate -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , P < @ -RSB- , drug use rates : lipid-lowering drugs -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) -RSB- , blockers -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) -RSB- , and ACEI/ARB -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) -RSB- were significantly higher in the intervention group than in the control group , while total cardiovascular event rates -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , P < @ -RSB- and out-patient medical costs ( @ RMB vs. @ RMB , P < @ ) were significantly lower in the intervention group than in the control group .", "sentence_id": 4}
+{"abstract_id": "24524600", "label": "results", "text": "The quality of life scores derived from MYO health survey questionnaire was significantly higher in the intervention group than in the control group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24524600", "label": "results", "text": "The top three reasons responsible for continuous smoking for all patients failed to quit smoking were : ( @ ) others smoked more than me and still alive and healthy -LSB- @ % ( @/@ ) -RSB- ; ( @ ) smoking helped me to keep relaxed and reduce trouble in daily work and life -LSB- @ % ( @/@ ) -RSB- ; ( @ ) smoking was essential while chatting and drinking with friends -LSB- @ % ( @/@ ) -RSB- .", "sentence_id": 6}
+{"abstract_id": "24524600", "label": "results", "text": "The overall satisfactory rate to this smoking cessation program was @ % and the satisfactory rate was up to @ % by patients .", "sentence_id": 7}
+{"abstract_id": "24524600", "label": "conclusions", "text": "Intensive outpatient smoking cessation follow-up program can significantly improve the smoking cessation rates , the guideline drug use rate and the quality of life while reduce medical costs for coronary heart disease patients .", "sentence_id": 8}
+{"abstract_id": "24439596", "label": "background", "text": "We conducted a prospective , randomized trial comparing protocol to ad libitum ( ad lib ) feeding after laparoscopic pyloromyotomy .", "sentence_id": 0}
+{"abstract_id": "24439596", "label": "methods", "text": "Infants undergoing laparoscopic pyloromyotomy were randomized to protocol versus ad lib feeding strategies .", "sentence_id": 1}
+{"abstract_id": "24439596", "label": "methods", "text": "The protocol started with Pedialyte two hours post-operative .", "sentence_id": 2}
+{"abstract_id": "24439596", "label": "methods", "text": "This was repeated by another round of Pedialyte , then two rounds of half-strength formula or breast milk , followed by two rounds of full strength formula or breast milk , followed by the home feeding regimen , at which time the patient was discharged if feeding well .", "sentence_id": 3}
+{"abstract_id": "24439596", "label": "methods", "text": "The ad lib group was allowed formula or breast milk two hours after the operation and considered for discharge after tolerating three consecutive feeds .", "sentence_id": 4}
+{"abstract_id": "24439596", "label": "methods", "text": "The primary outcome variable was the length of postoperative hospitalization .", "sentence_id": 5}
+{"abstract_id": "24439596", "label": "results", "text": "One hundred fifty infants were enrolled between January @ and December @ .", "sentence_id": 6}
+{"abstract_id": "24439596", "label": "results", "text": "There were no differences in patient characteristics at presentation .", "sentence_id": 7}
+{"abstract_id": "24439596", "label": "results", "text": "While the ad lib group reached goal feeds sooner than the protocol group , this did not translate into a difference in duration of postoperative hospitalization .", "sentence_id": 8}
+{"abstract_id": "24439596", "label": "results", "text": "There were more patients with emesis in the ad lib group after goal feeding was reached , but no difference in readmissions .", "sentence_id": 9}
+{"abstract_id": "24439596", "label": "conclusions", "text": "Ad lib feeding allows patients to reach goal feeds more rapidly than protocol feeding following laparoscopic pyloromyotomy .", "sentence_id": 10}
+{"abstract_id": "24439596", "label": "conclusions", "text": "However , this goal is usually reached beyond discharge hours , resulting in a similar duration of hospitalization .", "sentence_id": 11}
+{"abstract_id": "25761587", "label": "objective", "text": "To evaluate the efficacy of dienogest + estradiol valerate ( E@V ) and gonadotrophin-releasing hormone analogue ( GnRH-a ) in reducing recurrence of pain in patients with chronic pelvic pain due to laparoscopically diagnosed and treated endometriosis .", "sentence_id": 0}
+{"abstract_id": "25761587", "label": "methods", "text": "Multi-center , prospective , randomized study .", "sentence_id": 1}
+{"abstract_id": "25761587", "label": "methods", "text": "Three university departments of obstetrics and gynecology in Italy .", "sentence_id": 2}
+{"abstract_id": "25761587", "label": "methods", "text": "Seventy-eight women who underwent laparoscopic surgery for endometriosis combined with chronic pelvic pain .", "sentence_id": 3}
+{"abstract_id": "25761587", "label": "methods", "text": "Post-operative administration of dienogest + E@V for @ months ( group @ ) or GnRH-a monthly for @ months ( group @ ) .", "sentence_id": 4}
+{"abstract_id": "25761587", "label": "methods", "text": "A visual analogue scale was used to test intensity of pain before laparoscopic surgery at @ , @ and @ months of follow up .", "sentence_id": 5}
+{"abstract_id": "25761587", "label": "methods", "text": "A questionnaire to investigate quality of life was administered before surgery and at @ months of follow up .", "sentence_id": 6}
+{"abstract_id": "25761587", "label": "results", "text": "The visual analogue scale score did not show any significant differences between the two groups ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25761587", "label": "results", "text": "The questionnaire showed an increase of scores for all women compared with pre-surgery values , demonstrating a marked improvement in quality of life and health-related satisfaction with both treatments .", "sentence_id": 8}
+{"abstract_id": "25761587", "label": "results", "text": "No significant differences were found between the groups .", "sentence_id": 9}
+{"abstract_id": "25761587", "label": "results", "text": "The rate of apparent endometriosis recurrence was @ % in group @ and @ % in group @ ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25761587", "label": "conclusions", "text": "Both therapies seemed equally efficacious in preventing endometriosis-related chronic pelvic pain recurrence in the first @ months of follow-up .", "sentence_id": 11}
+{"abstract_id": "25084967", "label": "background", "text": "The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown .", "sentence_id": 0}
+{"abstract_id": "25084967", "label": "background", "text": "The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity .", "sentence_id": 1}
+{"abstract_id": "25084967", "label": "methods", "text": "This was an analysis of @ mother and infant pairs from the ROLO study ( Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia ) .", "sentence_id": 2}
+{"abstract_id": "25084967", "label": "methods", "text": "Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy .", "sentence_id": 3}
+{"abstract_id": "25084967", "label": "methods", "text": "Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth .", "sentence_id": 4}
+{"abstract_id": "25084967", "label": "results", "text": "Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R@adj @ % ( F = @ , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25084967", "label": "results", "text": "The main maternal factor associated with increased birth length was non-smoking status R@adj @ % ( F = @ , p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25084967", "label": "results", "text": "Neonatal central adiposity ( determined using waist : length ratio ) was negatively associated with maternal age , and positively associated with the following parameters : smoking status , maternal pre-pregnancy arm circumference , percentage energy from saturated fat in late pregnancy , postprandial glucose at @ weeks gestation and membership of the control group with a positive trend towards association with trimester @ glycaemic load R@adj @ % ( F = @ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25084967", "label": "conclusions", "text": "Several maternal diet and lifestyle factors were associated with neonatal anthropometry .", "sentence_id": 8}
+{"abstract_id": "25084967", "label": "conclusions", "text": "Low glycaemic index dietary intervention in pregnancy was found to have a beneficial effect on neonatal central adiposity .", "sentence_id": 9}
+{"abstract_id": "25084967", "label": "conclusions", "text": "Additionally , central adiposity was positively associated with maternal dietary fat intake and postprandial glucose highlighting the important role of healthy diet in pregnancy in promoting normal neonatal adiposity .", "sentence_id": 10}
+{"abstract_id": "24737786", "label": "objective", "text": "To estimate the incremental cost-effectiveness of infliximab versus conventional combination treatment over @months in patients with methotrexate-refractory early rheumatoid arthritis .", "sentence_id": 0}
+{"abstract_id": "24737786", "label": "methods", "text": "In this multicentre , two-arm , parallel , randomised , active-controlled , open-label trial , rheumatoid arthritis patients with < @year symptom duration were recruited from @ rheumatology clinics in Sweden between October @ and December @ .", "sentence_id": 1}
+{"abstract_id": "24737786", "label": "methods", "text": "After @-@months of methotrexate monotherapy , patients not achieving low disease activity were randomised to addition of infliximab or sulfasalazine + hydroxychloroquine ( conventional treatment group ) .", "sentence_id": 2}
+{"abstract_id": "24737786", "label": "methods", "text": "Costs of drugs , healthcare use , and productivity losses were retrieved from nationwide registers , while EuroQol @-Dimensions utility was collected quarterly .", "sentence_id": 3}
+{"abstract_id": "24737786", "label": "results", "text": "Of @ patients initially enrolled , @ and @ were randomised to infliximab and conventional treatment , respectively .", "sentence_id": 4}
+{"abstract_id": "24737786", "label": "results", "text": "The infliximab group accumulated higher drug and healthcare costs ( @,@ vs @,@ ; adjusted mean difference @,@ ( @ % CI @,@ to @,@ ) ) , while productivity losses did not differ ( @,@ vs @,@ ; @ ( @ % CI -@ to @,@ ) ) , resulting in higher societal cost compared to the conventional group ( @,@ vs @,@ ; @,@ ( @ % CI @,@ to @,@ ) ) .", "sentence_id": 5}
+{"abstract_id": "24737786", "label": "results", "text": "Mean accumulated quality-adjusted life-years ( QALYs ) did not differ ( @ vs @ ; adjusted mean difference favouring infliximab treatment @ ( @ % CI -@ to @ ) ) .", "sentence_id": 6}
+{"abstract_id": "24737786", "label": "results", "text": "The incremental cost-effectiveness ratios for the infliximab versus conventional treatment strategy were @,@,@ / QALY from the societal perspective and @,@,@ / QALY from the healthcare perspective .", "sentence_id": 7}
+{"abstract_id": "24737786", "label": "conclusions", "text": "In early , methotrexate-refractory rheumatoid arthritis , a treatment strategy commencing with addition of infliximab , as compared to sulfasalazine + hydroxychloroquine , was not cost-effective over @months at willingness to pay levels generally considered acceptable .", "sentence_id": 8}
+{"abstract_id": "24655054", "label": "objective", "text": "To identify growth-related collagen and bone parameters in small-for-gestational-age ( SGA ) and appropriate-for-gestational-age ( AGA ) preterm infants during the first six months post-term .", "sentence_id": 0}
+{"abstract_id": "24655054", "label": "objective", "text": "In SGA preterm infants , increased growth and decreased bone acquisition , which we demonstrated previously , may be reflected by these markers .", "sentence_id": 1}
+{"abstract_id": "24655054", "label": "methods", "text": "Observational study within a randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "24655054", "label": "methods", "text": "Thirty-three SGA ( weight , length or both at birth < -@ SDS ) and @ AGA preterm infants ( gestational age -LSB- median ( IQR ) -RSB- : @ ( @ ) vs @ ( @ ) weeks ; @ % vs @ % boys ) .", "sentence_id": 3}
+{"abstract_id": "24655054", "label": "methods", "text": "Weight ( g ) , length ( cm ) , procollagen type I N-terminal peptide ( PINP ; g/l ) , urinary helical peptide ( UHP ; g/mmol creatinine ) and alkaline phosphatase ( ALP ; U/l ) expressed as standard deviation scores ( SDS ) at term age , three and six months post-term .", "sentence_id": 4}
+{"abstract_id": "24655054", "label": "results", "text": "Weight and length gain during the first six months post-term and PINP SDS at term age , three months and six months post-term were higher in SGA compared with AGA infants .", "sentence_id": 5}
+{"abstract_id": "24655054", "label": "results", "text": "UHP SDS and ALP SDS were similar in SGA and AGA infants .", "sentence_id": 6}
+{"abstract_id": "24655054", "label": "results", "text": "PINP SDS and UHP SDS at term age and PINP SDS at three months were associated with subsequent weight and length gain until six months post-term .", "sentence_id": 7}
+{"abstract_id": "24655054", "label": "conclusions", "text": "Increased growth in SGA compared with AGA preterm infants is reflected by increased collagen type I synthesis during the first six months post-term , suggesting that PINP and UHP correspond with growth in preterm infants .", "sentence_id": 8}
+{"abstract_id": "24655054", "label": "conclusions", "text": "An explanation for decreased bone acquisition of SGA preterm infants may be that increased collagen type I synthesis is not directly followed by increased bone mineralization .", "sentence_id": 9}
+{"abstract_id": "25758273", "label": "background", "text": "Current randomized trials have demonstrated the effects of short-term rosuvastatin therapy in preventing contrast-induced acute kidney injury ( CIAKI ) .", "sentence_id": 0}
+{"abstract_id": "25758273", "label": "background", "text": "However , the consistency of these effects on patients administered different volumes of contrast media is unknown .", "sentence_id": 1}
+{"abstract_id": "25758273", "label": "methods", "text": "In the TRACK-D trial , @ patients with type @ diabetes and concomitant chronic kidney disease ( CKD ) who underwent coronary/peripheral arterial angiography with or without percutaneous intervention were randomized to short-term ( @ days before and @ days after procedure ) rosuvastatin therapy or standard-of-care .", "sentence_id": 2}
+{"abstract_id": "25758273", "label": "methods", "text": "This prespecified analysis compared the effects of rosuvastatin versus standard therapy in patients exposed to ( moderate contrast volume -LSB- MCV -RSB- , @-@ ml , n = @ ) or ( high contrast volume -LSB- HCV -RSB- , @ ml , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25758273", "label": "methods", "text": "The primary outcome was the incidence of CIAKI .", "sentence_id": 4}
+{"abstract_id": "25758273", "label": "methods", "text": "The secondary outcome was a composite of death , dialysis/hemofiltration or worsened heart failure at @ days .", "sentence_id": 5}
+{"abstract_id": "25758273", "label": "results", "text": "Rosuvastatin treatment was associated with a significant reduction in CIAKI compared with the controls ( @ % vs. @ % , P = @ ) in the overall cohort and in patients with MCV ( @ % vs. @ % , P = @ ) , whereas no benefit was observed in patients with HCV ( @ % vs. @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25758273", "label": "results", "text": "The incidence of secondary outcomes was significantly lower in the rosuvastatin group compared with control group ( @ % vs. @ % , P = @ ) in the overall cohort , but it was similar between the patients with MCV ( @ % vs. @ % , P = @ ) or HCV ( @ % vs. @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25758273", "label": "conclusions", "text": "Periprocedural short-term rosuvastatin treatment is effective in reducing CIAKI and adverse clinical events for patients with diabetes and CKD after their exposure to a moderate volume of contrast medium .", "sentence_id": 8}
+{"abstract_id": "25341356", "label": "objective", "text": "To investgate the effect of Xuebijing Injection on immune regulation in patients with systemic inflammatory response syndrome ( SIRS ) .", "sentence_id": 0}
+{"abstract_id": "25341356", "label": "methods", "text": "@ SIRS patients admitted to the ICU of Guizhou Provincial Hospital from January @ to December @ were included in this study .", "sentence_id": 1}
+{"abstract_id": "25341356", "label": "methods", "text": "The patients were randomly divided into a control ( C ) and a treatment ( T ) group .", "sentence_id": 2}
+{"abstract_id": "25341356", "label": "methods", "text": "Patients in C group received routine treatment ; while patients in T group received additional Xuebijing Injection @ mL Bid .", "sentence_id": 3}
+{"abstract_id": "25341356", "label": "methods", "text": "The following indicators were recorded and compared between the two groups before and @ and @ days after treatments : CD@ + , CD@ + , CD@ + / CD@ + , monocytes CD@ + / human leukocyte antigen-DR ( HLA-DR ) , score of acute physiology and chronic health evaluation II ( APACHE II ) , heart rate , white blood cells , body temperature , respiration rate , and MODS ( @ d after treatment only ) .", "sentence_id": 4}
+{"abstract_id": "25341356", "label": "results", "text": "No differences were found between the two groups before treatments ( P > @ ) .", "sentence_id": 5}
+{"abstract_id": "25341356", "label": "results", "text": "T Group had higher levels of CD@ + , CD@ , CD@ + / CD@ + and monocytes CD@ + / HLA-DR than C group at @ and @ d after treatments ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25341356", "label": "results", "text": "T group also had higher levels of improvement in vital indicators compared with C group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25341356", "label": "results", "text": "No significant difference in incidence of multiple organ dysfunction syndrome ( MODS ) was found between the two groups ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "25341356", "label": "conclusions", "text": "Xuebijing Injection can regulate immune function of patients with SIRS .", "sentence_id": 9}
+{"abstract_id": "24357423", "label": "background", "text": "Incisional hernias in old stoma wounds occur in one-third of former stoma patients and pose a significant clinical problem .", "sentence_id": 0}
+{"abstract_id": "24357423", "label": "background", "text": "Parastomal hernias can be prevented by prophylactic mesh placement ; however , no trial results are available for incisional hernia prevention after stoma reversal .", "sentence_id": 1}
+{"abstract_id": "24357423", "label": "background", "text": "In this feasibility study , we explore the safety of placing an intraperitoneal mesh to prevent incisional herniation after temporary stoma reversal .", "sentence_id": 2}
+{"abstract_id": "24357423", "label": "methods", "text": "Ten patients who underwent a low anterior resection with a deviating double-loop stoma for rectal cancer received an intraperitoneal parastomal mesh at the time of stoma formation .", "sentence_id": 3}
+{"abstract_id": "24357423", "label": "methods", "text": "At stoma reversal , laparoscopy was performed and adhesions were scored .", "sentence_id": 4}
+{"abstract_id": "24357423", "label": "methods", "text": "After reversal , the mesh defect was closed .", "sentence_id": 5}
+{"abstract_id": "24357423", "label": "methods", "text": "Mesh and stoma complications were closely monitored .", "sentence_id": 6}
+{"abstract_id": "24357423", "label": "methods", "text": "Incisional herniation was assessed at the @-year follow-up after stoma reversal using ultrasonography .", "sentence_id": 7}
+{"abstract_id": "24357423", "label": "results", "text": "No infections occurred after mesh placement .", "sentence_id": 8}
+{"abstract_id": "24357423", "label": "results", "text": "After a median of @ months , stomas were reversed .", "sentence_id": 9}
+{"abstract_id": "24357423", "label": "results", "text": "Laparoscopy could be performed in seven patients ; all patients had adhesions ( median of @ % of mesh surface ) .", "sentence_id": 10}
+{"abstract_id": "24357423", "label": "results", "text": "In three patients , the bowel was involved ; one required a laparotomy for bowel mobilization during stoma reversal .", "sentence_id": 11}
+{"abstract_id": "24357423", "label": "results", "text": "No adhesion-related morbidity was noted at any time .", "sentence_id": 12}
+{"abstract_id": "24357423", "label": "results", "text": "Except for one superficial wound infection after stoma reversal , no infectious complications were observed .", "sentence_id": 13}
+{"abstract_id": "24357423", "label": "results", "text": "After a median follow-up of @ months , no incisional herniations were demonstrated .", "sentence_id": 14}
+{"abstract_id": "24357423", "label": "conclusions", "text": "Prophylactic mesh placement in temporary stoma formations seems safe and feasible and prevents incisional herniation @ years after stoma reversal .", "sentence_id": 15}
+{"abstract_id": "25596659", "label": "background", "text": "We aimed to compare panitumumab , a fully human monoclonal antibody against EGFR , plus radiotherapy with chemoradiotherapy in patients with unresected , locally advanced squamous-cell carcinoma of the head and neck .", "sentence_id": 0}
+{"abstract_id": "25596659", "label": "methods", "text": "In this international , open-label , randomised , controlled , phase @ trial , we recruited patients with locally advanced squamous-cell carcinoma of the head and neck from @ sites in eight countries worldwide .", "sentence_id": 1}
+{"abstract_id": "25596659", "label": "methods", "text": "Patients aged @ years and older with stage III , IVa , or IVb , previously untreated , measurable ( @ mm for at least one dimension ) , locally advanced squamous-cell carcinoma of the head and neck ( non-nasopharygeal ) and an Eastern Cooperative Oncology Group performance status of @-@ were randomly assigned ( @:@ ) by an independent vendor to open-label chemoradiotherapy ( two cycles of cisplatin @ mg/m ( @ ) during radiotherapy ) or to radiotherapy plus panitumumab ( three cycles of panitumumab @ mg/kg every @ weeks administered with radiotherapy ) using a stratified randomisation with a block size of five .", "sentence_id": 2}
+{"abstract_id": "25596659", "label": "methods", "text": "All patients received @-@ Gy to gross tumour and @ Gy to areas of subclinical disease with accelerated fractionation radiotherapy .", "sentence_id": 3}
+{"abstract_id": "25596659", "label": "methods", "text": "The primary endpoint was local-regional control at @ years , analysed in all randomly assigned patients who received at least one dose of their assigned protocol-specific treatment ( chemotherapy , radiation , or panitumumab ) .", "sentence_id": 4}
+{"abstract_id": "25596659", "label": "methods", "text": "The trial is closed and this is the final analysis .", "sentence_id": 5}
+{"abstract_id": "25596659", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "25596659", "label": "results", "text": "Between Nov @ , @ , and Nov @ , @ , @ patients were enrolled , and @ received treatment ( @ in the chemoradiotherapy group and @ in the radiotherapy plus panitumumab group ) .", "sentence_id": 7}
+{"abstract_id": "25596659", "label": "results", "text": "Local-regional control at @ years was @ % ( @ % CI @-@ ) in the chemoradiotherapy group and @ % ( @-@ ) in the radiotherapy plus panitumumab group .", "sentence_id": 8}
+{"abstract_id": "25596659", "label": "results", "text": "The most frequent grade @-@ adverse events were mucosal inflammation ( @ -LSB- @ % -RSB- of @ patients in the chemoradiotherapy group vs @ -LSB- @ % -RSB- of @ patients in the radiotherapy plus panitumumab group ) , dysphagia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and radiation skin injury ( seven -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "25596659", "label": "results", "text": "Serious adverse events were reported in @ ( @ % ) of @ patients in the chemoradiotherapy group and in @ ( @ % ) of @ patients in the radiotherapy plus panitumumab group .", "sentence_id": 10}
+{"abstract_id": "25596659", "label": "conclusions", "text": "Panitumumab can not replace cisplatin in the combined treatment with radiotherapy for unresected stage III-IVb squamous-cell carcinoma of the head and neck , and the role of EGFR inhibition in locally advanced squamous-cell carcinoma of the head and neck needs to be reassessed .", "sentence_id": 11}
+{"abstract_id": "24852468", "label": "background", "text": "High-intensity focused ultrasound ( HIFU ) is a noninvasive alternative to traditional invasive body sculpting procedures .", "sentence_id": 0}
+{"abstract_id": "24852468", "label": "objective", "text": "To assess the effectiveness and tolerability of HIFU treatment using high and low fluence settings with @ treatment techniques , grid repeat ( GR ) and site repeat ( SR ) .", "sentence_id": 1}
+{"abstract_id": "24852468", "label": "methods", "text": "Two multicenter studies were conducted .", "sentence_id": 2}
+{"abstract_id": "24852468", "label": "methods", "text": "Subjects underwent @ HIFU treatment with @ of @ treatment protocols ( total fluence , @-@ J/cm ) .", "sentence_id": 3}
+{"abstract_id": "24852468", "label": "methods", "text": "Primary end point was change from baseline in waist circumference ( CBWC ) at @ weeks .", "sentence_id": 4}
+{"abstract_id": "24852468", "label": "methods", "text": "Secondary end points included CBWC at @ and @ weeks and investigator - and subject-assessed clinical improvement .", "sentence_id": 5}
+{"abstract_id": "24852468", "label": "methods", "text": "Adverse events were monitored throughout the study .", "sentence_id": 6}
+{"abstract_id": "24852468", "label": "results", "text": "In the intent-to-treat ( ITT ) population , all subjects had a statistically significant mean circumferential reduction of -@ @ cm ( p < @ ) from baseline at @ weeks , with no significant differences among the @ treatment groups ( ITT : p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24852468", "label": "results", "text": "Analysis of secondary end points in the ITT population demonstrated a significant circumferential reduction starting as early as @ weeks in all subjects ( -@ @ cm , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24852468", "label": "results", "text": "Most subjects in all treatment groups showed improvements at @ weeks as rated by the investigators and subjects .", "sentence_id": 9}
+{"abstract_id": "24852468", "label": "conclusions", "text": "High-intensity focused ultrasound treatment using either a low or high fluence setting in a GR or SR method is effective for circumferential waist reduction , resulting in statistically significant CBWC in all treatment groups .", "sentence_id": 10}
+{"abstract_id": "25797757", "label": "background", "text": "Postoperative readmissions have been proposed by Medicare as a quality metric and can impact provider reimbursement .", "sentence_id": 0}
+{"abstract_id": "25797757", "label": "background", "text": "Because readmission after pancreatectomy is common , we sought to identify factors associated with readmission to establish a predictive risk scoring system .", "sentence_id": 1}
+{"abstract_id": "25797757", "label": "methods", "text": "A retrospective analysis of @,@ pancreatectomies performed at @ high-volume pancreatic centers between @ and @ was performed .", "sentence_id": 2}
+{"abstract_id": "25797757", "label": "methods", "text": "Forty-five factors strongly associated with readmission were identified .", "sentence_id": 3}
+{"abstract_id": "25797757", "label": "methods", "text": "To derive and validate a risk scoring system , the population was randomly divided into @ cohorts in a @:@ fashion .", "sentence_id": 4}
+{"abstract_id": "25797757", "label": "methods", "text": "A multivariable logistic regression model was constructed and scores were assigned based on the relative odds ratio ( OR ) of each independent predictor .", "sentence_id": 5}
+{"abstract_id": "25797757", "label": "methods", "text": "A composite Readmission after Pancreatectomy ( RAP ) score was generated and then stratified to create risk groups .", "sentence_id": 6}
+{"abstract_id": "25797757", "label": "results", "text": "Overall , @ ( @ % ) patients were readmitted within @ days .", "sentence_id": 7}
+{"abstract_id": "25797757", "label": "results", "text": "Eight pre - and postoperative factors , including earlier MI ( OR = @ ) , American Society of Anesthesiologists class @ ( OR = @ ) , dementia ( OR = @ ) , hemorrhage ( OR = @ ) , delayed gastric emptying ( OR = @ ) , surgical site infection ( OR = @ ) , sepsis ( OR = @ ) , and short length of stay ( OR = @ ) were independently predictive of readmission .", "sentence_id": 8}
+{"abstract_id": "25797757", "label": "results", "text": "The @-point RAP score generated from the derivation cohort was highly predictive of readmission in the validation cohort ( area under the receiver operating curve = @ ) .", "sentence_id": 9}
+{"abstract_id": "25797757", "label": "results", "text": "The low-risk ( @ to @ ) , intermediate-risk ( @ to @ ) , and high-risk ( > @ ) groups correlated with @ % , @ % , and @ % observed readmission rates , respectively ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25797757", "label": "conclusions", "text": "The RAP score is a novel and clinically useful risk scoring system for readmission after pancreatectomy .", "sentence_id": 11}
+{"abstract_id": "25797757", "label": "conclusions", "text": "Identification of patients with increased risk of readmission using the RAP score will allow efficient resource allocation aimed to attenuate readmission rates .", "sentence_id": 12}
+{"abstract_id": "25797757", "label": "conclusions", "text": "It also has potential to serve as a new metric for comparative research and quality assessment .", "sentence_id": 13}
+{"abstract_id": "24314158", "label": "objective", "text": "To compare the induction of remission and cost-effectiveness of enteral nutrition ( EN ) and infliximab ( IFX ) in moderate-to-severe active Crohn 's disease ( CD ) .", "sentence_id": 0}
+{"abstract_id": "24314158", "label": "methods", "text": "Moderate-to-severe active CD patients were divided into IFX group and EN group .", "sentence_id": 1}
+{"abstract_id": "24314158", "label": "methods", "text": "Remission rate , time to remission and treatment cost were compared between the two groups .", "sentence_id": 2}
+{"abstract_id": "24314158", "label": "methods", "text": "Clinical remission was defined as Crohn 's disease activity index ( CDAI ) < @ .", "sentence_id": 3}
+{"abstract_id": "24314158", "label": "methods", "text": "The quality of life was evaluated by inflammatory bowel disease questionnaire of quality of life ( IBDQ ) .", "sentence_id": 4}
+{"abstract_id": "24314158", "label": "results", "text": "A total of @ patients were analyzed , including @ patients in IFX group and @ patients in EN group .", "sentence_id": 5}
+{"abstract_id": "24314158", "label": "results", "text": "IFX group had higher remission rate -LSB- @ % ( @/@ ) vs @ % ( @/@ ) , P = @ -RSB- and shorter time to remission -LSB- ( @ @ ) days vs ( @ @ ) days , P < @ -RSB- than EN group .", "sentence_id": 6}
+{"abstract_id": "24314158", "label": "results", "text": "Treatment costs before remission were similar in two groups ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24314158", "label": "results", "text": "The increase of IBDQ scores before and after treatment in IFX group was much higher than that of EN group ( @ @ vs @ @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24314158", "label": "results", "text": "Similarly , patients in EN group had greater increase of body mass index ( BMI ) than that of IFX group -LSB- ( @ @ ) kg/m ( @ ) vs ( @ @ ) kg/m ( @ ) , P < @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "24314158", "label": "results", "text": "For patients with CDAI < @ , remission rate was not significantly different -LSB- @ % ( @/@ ) vs @ % ( @/@ ) , P = @ -RSB- between the two groups , while treatment cost in EN group was less than that of IFX group -LSB- ( @ @ ) @ ( @ ) RMB vs ( @ @ ) @ ( @ ) RMB , P = @ -RSB- .", "sentence_id": 10}
+{"abstract_id": "24314158", "label": "conclusions", "text": "For patients with severe CD ( CDAI @ ) , IFX has higher remission rate , shorter time to remission and comparable treatment cost than EN .", "sentence_id": 11}
+{"abstract_id": "24314158", "label": "conclusions", "text": "But for patients with CDAI < @ , EN group has comparable remission rate to IFX group with lower cost .", "sentence_id": 12}
+{"abstract_id": "25050898", "label": "background", "text": "Testicular germ cell cancer ( GCC ) patients treated with cisplatin-etoposide-bleomycin chemotherapy ( BEP ) have excellent prognosis but have an increased risk of late-occurring morbidities , which may be associated with changes in the inflammatory profile .", "sentence_id": 0}
+{"abstract_id": "25050898", "label": "objective", "text": "The objective of the study was to explore plasma cytokine concentrations in GCC patients randomized to resistance training or usual care during BEP , in comparison with healthy controls .", "sentence_id": 1}
+{"abstract_id": "25050898", "label": "methods", "text": "This was a randomized controlled trial in GCC patients enrolled from an oncology clinic , including a healthy reference group for comparison purposes .", "sentence_id": 2}
+{"abstract_id": "25050898", "label": "methods", "text": "Plasma granulocyte macrophage colony-stimulating factor , interferon - , IL-@ , IL-@ , IL-@ , IL-@ , IL-@ , IL-@ , and TNF - were measured in fasting blood samples from GCC patients randomized to resistance training ( INT ; n = @ ) or usual care ( CON ; n = @ ) and healthy age-matched controls ( REF ; n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25050898", "label": "methods", "text": "Clinical toxicity assessments and patient-reported end points were also recorded .", "sentence_id": 4}
+{"abstract_id": "25050898", "label": "results", "text": "CON and INT were balanced at baseline .", "sentence_id": 5}
+{"abstract_id": "25050898", "label": "results", "text": "Compared with REF , CON had higher concentrations of IL-@ , IL-@ , and interferon - , and INT had higher concentrations of IL-@ , IL-@ and TNF - ( all P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25050898", "label": "results", "text": "At the end of therapy , concentrations of IL-@ , IL-@ , and IL-@ increased in both GCC groups ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25050898", "label": "results", "text": "Three months after therapy , all cytokine concentrations were comparable with the pretreatment levels in both GCC-groups but remained elevated compared with REF ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25050898", "label": "results", "text": "Changes in TNF - correlated with pulmonary toxicity ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25050898", "label": "results", "text": "At the end of therapy , IL-@ concentrations correlated with quality of life ( P < @ ) and fatigue ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25050898", "label": "conclusions", "text": "GCC patients treated with BEP display consistently elevated levels of systemic inflammatory markers compared with healthy controls .", "sentence_id": 11}
+{"abstract_id": "25050898", "label": "conclusions", "text": "Resistance training during therapy has no impact on plasma cytokine concentrations .", "sentence_id": 12}
+{"abstract_id": "25295437", "label": "objective", "text": "This work tested the hypothesis that patients with high negative affectivity ( NA ) would have a better response to a serotonergic agent ( escitalopram ) than to one not thought to act directly on serotonin ( bupropion ) .", "sentence_id": 0}
+{"abstract_id": "25295437", "label": "methods", "text": "Data from a study conducted between August @ and July @ were reanalyzed retrospectively .", "sentence_id": 1}
+{"abstract_id": "25295437", "label": "methods", "text": "Patients ( N = @ ) meeting criteria for major depressive disorder ( MDD ) , diagnosed with DSM-IV-TR , were randomly assigned to double-blind treatment with bupropion extended-release , escitalopram , or the combination .", "sentence_id": 2}
+{"abstract_id": "25295437", "label": "methods", "text": "Negative affectivity score was estimated using the guilt , hostility/irritability , and fear/anxiety items of the Hamilton Depression Rating Scale , the Montgomery-Asberg Depression Rating Scale , the Quick Inventory of Depressive Symptoms , and the Social Adjustment Scale .", "sentence_id": 3}
+{"abstract_id": "25295437", "label": "methods", "text": "We felt that these items captured published descriptions of the NA construct .", "sentence_id": 4}
+{"abstract_id": "25295437", "label": "methods", "text": "A Clinical Global Impressions-Severity of Illness ( CGI-S ) score @ defined response .", "sentence_id": 5}
+{"abstract_id": "25295437", "label": "methods", "text": "Because combined treatment addressed both serotonin and non-serotonin systems , patients treated with both medications did not test the hypothesis and so were excluded from the analyses .", "sentence_id": 6}
+{"abstract_id": "25295437", "label": "results", "text": "Analysis of covariance with treatment as a grouping variable , NA as covariate , and CGI-S as dependent variable showed a significant @-way interaction between treatment and NA ( F , = @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25295437", "label": "results", "text": "In the low-NA group , response rates were similar between treatments ( escitalopram : @/@ -LSB- @ % -RSB- ; bupropion : @/@ -LSB- @ % -RSB- ; NS ) , while there was a significant advantage for escitalopram in patients with high NA ( escitalopram : @/@ -LSB- @ % -RSB- ; bupropion = @/@ -LSB- @ % -RSB- ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25295437", "label": "conclusions", "text": "These data suggest that patients with high negative affectivity respond preferentially to antidepressants that selectively enhance serotonin neurotransmission .", "sentence_id": 9}
+{"abstract_id": "25295437", "label": "conclusions", "text": "Although patients with low NA appear to benefit from serotonin enhancement as well , they also improved with bupropion , an antidepressant not thought to directly affect serotonin neurotransmission .", "sentence_id": 10}
+{"abstract_id": "25295437", "label": "conclusions", "text": "These findings come from retrospective analyses using unproven approximation of NA , so no clinical inferences should be made before independent replication utilizing accepted NA measurement .", "sentence_id": 11}
+{"abstract_id": "25415108", "label": "background", "text": "There is no consensus on the efficacy of postoperative infusion of local anesthetics after radical mastectomy .", "sentence_id": 0}
+{"abstract_id": "25415108", "label": "methods", "text": "A randomized , double-blind , placebo-controlled , parallel-groups clinical trial was conducted in a tertiary hospital .", "sentence_id": 1}
+{"abstract_id": "25415108", "label": "methods", "text": "Eighty consecutive women with operable breast cancer with indications for modified radical mastectomy without breast reconstruction were assigned randomly to receive infusion of levobupivacaine ( @ % ) or saline at @ ml/hour for @ hours through a wound catheter .", "sentence_id": 2}
+{"abstract_id": "25415108", "label": "methods", "text": "Seventy-three women finished the study ( intervention group , n = @ ; control group , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25415108", "label": "methods", "text": "During surgery , all patients received @ % levobupivacaine ( @ ml ) .", "sentence_id": 4}
+{"abstract_id": "25415108", "label": "results", "text": "The levobupivacaine group reported less pain ( p < @ ) than controls in the postanesthesia care unit ( @ @ versus @ @ ) and on the ward at @ ( @ @ versus @ @ ) and @ ( @ @ versus @ @ ) hours .", "sentence_id": 5}
+{"abstract_id": "25415108", "label": "results", "text": "In the postanesthesia care unit , the levobupivacaine group consumed less metamizole ( @ @ versus @ @ ; p < @ ) and dexketoprofen ( @ @ versus @ @ ; p < @ ) , with differences in paracetamol use being insignificant ( @ @ versus @ @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25415108", "label": "results", "text": "On the ward , the levobupivacaine group used significantly less paracetamol ( @ @ versus @ @ ; p < @ ) and metamizole ( @ @ versus @ @ ; p < @ ) , but differences in dexketoprofen were not significant ( @ @ versus @ @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25415108", "label": "results", "text": "In the postanesthesia care unit , the levobupivacaine and control groups consumed @ @ and @ @ doses of opioids ( p = @ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "25415108", "label": "results", "text": "The authors observed no differences in nausea and vomiting at any stage in the postanesthesia care unit ( @ @ versus @ @ ; p = @ ) or on the ward ( @ @ versus @ @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25415108", "label": "results", "text": "All participants reported high levels of satisfaction .", "sentence_id": 10}
+{"abstract_id": "25415108", "label": "conclusions", "text": "Continuous infusion of local anesthetic reduces pain and analgesic consumption , with high satisfaction , but does not affect rates of nausea and vomiting .", "sentence_id": 11}
+{"abstract_id": "24876261", "label": "objective", "text": "The Interventional Management of Stroke ( IMS ) III study tested the effect of intravenous tissue-type plasminogen activator ( tPA ) alone when compared with intravenous tPA followed by endovascular therapy and collected cost data to assess the economic implications of the @ therapies .", "sentence_id": 0}
+{"abstract_id": "24876261", "label": "objective", "text": "This report describes the factors affecting the costs of the initial hospitalization for acute stroke subjects from the United States .", "sentence_id": 1}
+{"abstract_id": "24876261", "label": "methods", "text": "Prospective cost analysis of the US subjects was treated with intravenous tPA alone or with intravenous tPA followed by endovascular therapy in the IMS III trial .", "sentence_id": 2}
+{"abstract_id": "24876261", "label": "methods", "text": "Results were compared with expected Medicare payments .", "sentence_id": 3}
+{"abstract_id": "24876261", "label": "results", "text": "The adjusted cost of a stroke admission in the study was $ @ @ for subjects treated with endovascular therapy after intravenous tPA treatment and $ @ @ for subjects treated with intravenous tPA alone ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24876261", "label": "results", "text": "Significant factors related to costs included treatment group , baseline National Institutes of Health Stroke Scale , time from stroke onset to intravenous tPA , age , stroke location , and comorbid diabetes mellitus .", "sentence_id": 5}
+{"abstract_id": "24876261", "label": "results", "text": "The mean cost for subjects who had routine use of general anesthesia as part of endovascular therapy was $ @ @ when compared with $ @ @ for those who did not have general anesthesia .", "sentence_id": 6}
+{"abstract_id": "24876261", "label": "results", "text": "The costs of embolectomy for IMS III subjects and patients from the National Inpatient Sample cohort exceeded the Medicare diagnosis-related group payment in @ % of patients .", "sentence_id": 7}
+{"abstract_id": "24876261", "label": "conclusions", "text": "Minimizing the time to start of intravenous tPA and decreasing the use of routine general anesthesia may improve the cost-effectiveness of medical and endovascular therapy for acute stroke .", "sentence_id": 8}
+{"abstract_id": "24675168", "label": "background", "text": "Dietary linoleic acid ( LA , @:@ n-@ ) lowering in rats reduces n-@ polyunsaturated fatty acid ( PUFA ) plasma concentrations and increases n-@ PUFA ( eicosapentaenoic ( EPA ) and docosahexaenoic acid ( DHA ) ) concentrations .", "sentence_id": 0}
+{"abstract_id": "24675168", "label": "objective", "text": "To evaluate the extent to which @ weeks of dietary n-@ PUFA lowering , with or without increased dietary n-@ PUFAs , alters unesterified and esterified plasma n-@ and n-@ PUFA concentrations in subjects with chronic headache .", "sentence_id": 1}
+{"abstract_id": "24675168", "label": "methods", "text": "Secondary analysis of a randomized trial .", "sentence_id": 2}
+{"abstract_id": "24675168", "label": "methods", "text": "Subjects with chronic headache were randomized for @ weeks to ( @ ) average n-@ , low n-@ ( L@ ) diet ; or ( @ ) high n-@ , low n-@ LA ( H@-L@ ) diet .", "sentence_id": 3}
+{"abstract_id": "24675168", "label": "methods", "text": "Esterified and unesterified plasma fatty acids were quantified at baseline ( @ weeks ) and after @ weeks on a diet .", "sentence_id": 4}
+{"abstract_id": "24675168", "label": "results", "text": "Compared to baseline , the L@ diet reduced esterified plasma LA and increased esterified n-@ PUFA concentrations ( nmol/ml ) , but did not significantly change plasma arachidonic acid ( AA , @:@ n-@ ) concentration .", "sentence_id": 5}
+{"abstract_id": "24675168", "label": "results", "text": "In addition , unesterified EPA concentration was increased significantly among unesterified fatty acids .", "sentence_id": 6}
+{"abstract_id": "24675168", "label": "results", "text": "The H@-L@ diet decreased esterified LA and AA concentrations , and produced more marked increases in esterified and unesterified n-@ PUFA concentrations .", "sentence_id": 7}
+{"abstract_id": "24675168", "label": "conclusions", "text": "Dietary n-@ PUFA lowering for @ weeks significantly reduces LA and increases n-@ PUFA concentrations in plasma , without altering plasma AA concentration .", "sentence_id": 8}
+{"abstract_id": "24675168", "label": "conclusions", "text": "A concurrent increase in dietary n-@ PUFAs for @ weeks further increases n-@ PUFA plasma concentrations and reduces AA .", "sentence_id": 9}
+{"abstract_id": "24656221", "label": "objective", "text": "Cognitive behaviour therapy ( CBT ) has been found to reduce the impact of menopausal symptoms , hot flushes and night sweats .", "sentence_id": 0}
+{"abstract_id": "24656221", "label": "objective", "text": "This study investigates the moderators and mediators of CBT for women who had problematic menopausal symptoms following breast cancer treatment .", "sentence_id": 1}
+{"abstract_id": "24656221", "label": "methods", "text": "Analysis of @ patients with breast cancer induced menopausal symptoms recruited to the MENOS@ trial ; @ were randomly assigned to Group CBT and @ to usual care .", "sentence_id": 2}
+{"abstract_id": "24656221", "label": "methods", "text": "Questionnaires were completed at baseline , @ and @ weeks post randomisation .", "sentence_id": 3}
+{"abstract_id": "24656221", "label": "methods", "text": "Potential moderators and mediators , including sociodemographic , clinical and psychological factors , of the treatment effect on the primary outcome were examined .", "sentence_id": 4}
+{"abstract_id": "24656221", "label": "methods", "text": "Hot Flush Problem Rating .", "sentence_id": 5}
+{"abstract_id": "24656221", "label": "results", "text": "CBT was effective at reducing problem rating at @ weeks regardless of age , BMI , time since breast cancer diagnosis , menopausal status at time of diagnosis , or type of cancer treatment ( radiotherapy or chemotherapy or endocrine treatment ) .", "sentence_id": 6}
+{"abstract_id": "24656221", "label": "results", "text": "The treatment effect was significantly greater in women not receiving chemotherapy , those with higher levels of psychological distress at baseline and for non-white women .", "sentence_id": 7}
+{"abstract_id": "24656221", "label": "results", "text": "Beliefs about control/coping with hot flushes were the main mediators of improvement in problem rating following CBT .", "sentence_id": 8}
+{"abstract_id": "24656221", "label": "results", "text": "Beliefs about hot flushes in a social context , depressed mood and sleep problems were also identified as mediators .", "sentence_id": 9}
+{"abstract_id": "24656221", "label": "conclusions", "text": "These findings suggest that CBT is widely applicable for breast cancer patients who are experiencing treatment related menopausal symptoms , and that CBT works mainly by changing beliefs and improving mood and sleep .", "sentence_id": 10}
+{"abstract_id": "25985806", "label": "objective", "text": "Opioid-induced androgen deficiency ( OPIAD ) affects patients treated with opioid analgesics .", "sentence_id": 0}
+{"abstract_id": "25985806", "label": "objective", "text": "The norepinephrine reuptake inhibitor ( NRI ) and - opioid receptor ( MOR ) agonist activities of tapentadol may result in tapentadol having less effect on serum androgen concentrations than analgesics acting through the MOR alone , such as morphine and oxycodone .", "sentence_id": 1}
+{"abstract_id": "25985806", "label": "objective", "text": "The objectives of this publication are to @ ) evaluate the effects of tapentadol ( NUCYNTA and NUCYNTA extended release -LSB- ER -RSB- ) on sex hormone concentrations in healthy male volunteers ( vs placebo and morphine ) and patients with osteoarthritis ( vs placebo and oxycodone ) , and @ ) present a mechanistic hypothesis explaining how the combined MOR agonist and NRI activities of tapentadol may result in less impact on androgen concentrations .", "sentence_id": 2}
+{"abstract_id": "25985806", "label": "methods", "text": "Three clinical studies were conducted : study @ ( single-dose comparison study vs morphine in healthy volunteers ) , study @ ( single-dose-escalation study in healthy volunteers without an active comparator ) , and study @ ( multiple-dose study vs oxycodone in patients with osteoarthritis ) .", "sentence_id": 3}
+{"abstract_id": "25985806", "label": "methods", "text": "Studies @ and @ were conducted at medical research centers in Germany and the United Kingdom ; study @ was conducted at primary and secondary care centers and medical research centers in the United States .", "sentence_id": 4}
+{"abstract_id": "25985806", "label": "methods", "text": "All three studies were randomized , double blind , and placebo controlled .", "sentence_id": 5}
+{"abstract_id": "25985806", "label": "methods", "text": "Concentrations of testosterone , luteinizing hormone ( LH ) , and follicle-stimulating hormone ( FSH ; study @ only ) were evaluated at @ and @ hours postdose in studies @ and @ , respectively , and at varying time points postdose in study @ .", "sentence_id": 6}
+{"abstract_id": "25985806", "label": "results", "text": "In study @ , mean serum total testosterone concentrations in healthy male volunteers were similar at baseline for all treatment periods ; @ hours after dosing , mean concentrations were comparable between placebo ( @ nmol/L ) and tapentadol immediate release ( IR ; @ mg , @ nmol/L ; @ mg , @ nmol/L ) , but were lower following administration of morphine IR @ mg ( @ nmol/L ) .", "sentence_id": 7}
+{"abstract_id": "25985806", "label": "results", "text": "In study @ , there were no or minimal changes in testosterone in the therapeutic dose range with tapentadol IR ( @-@ mg ) , and there was a modest decrease that appeared to level off in the supratherapeutic range ( @-@ mg ) ; mean testosterone and LH concentrations with all doses remained within normal ranges ( testosterone , @-@ @ nmol/L ; LH , @-@ @ U/L ) .", "sentence_id": 8}
+{"abstract_id": "25985806", "label": "results", "text": "In study @ , the decrease in the mean -LSB- standard deviation -RSB- testosterone concentration from baseline to endpoint for male patients receiving tapentadol ER ( @ mg , -@ -LSB- @ -RSB- nmol/L ; @ mg , -@ -LSB- @ -RSB- nmol/L ) was numerically smaller compared to oxycodone CR ( @ mg , -@ -LSB- @ -RSB- nmol/L ) , but higher compared to placebo ( -@ -LSB- @ -RSB- nmol/L ) .", "sentence_id": 9}
+{"abstract_id": "25985806", "label": "conclusions", "text": "These results suggest that tapentadol , which has combined MOR and NRI activities , may have a lower impact on sex hormone concentrations than pure opioid analgesics , such as morphine or oxycodone .", "sentence_id": 10}
+{"abstract_id": "25985806", "label": "conclusions", "text": "The data and mechanistic rationale presented herein provide a justification for conducting additional hypothesis testing studies , and are not intended to be used as a basis for clinical decision making .", "sentence_id": 11}
+{"abstract_id": "25985806", "label": "conclusions", "text": "Future studies may help elucidate whether the observed trends are clinically significant and would translate into a reduced incidence of OPIAD .", "sentence_id": 12}
+{"abstract_id": "24229754", "label": "objective", "text": "Evaluate the @-week efficacy and safety of desvenlafaxine at the recommended dose of @ mg/d in perimenopausal and postmenopausal women with major depressive disorder ( MDD ) based on the Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition , Text Revision .", "sentence_id": 0}
+{"abstract_id": "24229754", "label": "methods", "text": "This phase @ , multicenter , parallel-group , randomized , double-blind , placebo-controlled study was conducted from June @ , @ , to June @ , @ .", "sentence_id": 1}
+{"abstract_id": "24229754", "label": "methods", "text": "Patients received placebo or desvenlafaxine @ mg/d ( @:@ ratio ; n = @ in each group ) .", "sentence_id": 2}
+{"abstract_id": "24229754", "label": "methods", "text": "The primary outcome measure was the change at week @ in the @-item Hamilton Depression Rating Scale ( HDRS@ ) total score .", "sentence_id": 3}
+{"abstract_id": "24229754", "label": "methods", "text": "Secondary outcome measures included change in the Sheehan Disability Scale ( SDS ) , the Clinical Global Impressions-Improvement scale ( CGI-I ) , the Montgomery-Asberg Depression Rating Scale ( MADRS ) , and the Visual Analog Scale-Pain Intensity ( VAS-PI ) .", "sentence_id": 4}
+{"abstract_id": "24229754", "label": "results", "text": "At end point , compared to placebo , desvenlafaxine was associated with a significantly greater decrease in HDRS@ total scores ( last-observation-carried-forward analysis ; adjusted mean change from baseline -@ vs -@ , respectively ; P = @ ) and significant improvements on the CGI-I ( P < @ ) , MADRS ( P = @ ) , SDS ( P = @ ) , and VAS-PI ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24229754", "label": "results", "text": "Improvements on the SDS and VAS-PI reached significance by week @ .", "sentence_id": 6}
+{"abstract_id": "24229754", "label": "results", "text": "Desvenlafaxine was generally safe and well tolerated .", "sentence_id": 7}
+{"abstract_id": "24229754", "label": "conclusions", "text": "Short-term treatment with desvenlafaxine @ mg/d was effective for the treatment of MDD in perimenopausal and postmenopausal women , with significant benefits on pain and functional outcomes evident as early as week @ .", "sentence_id": 8}
+{"abstract_id": "24229754", "label": "conclusions", "text": "The safety and tolerability of desvenlafaxine were consistent with data in other populations .", "sentence_id": 9}
+{"abstract_id": "24452791", "label": "objective", "text": "Anemia is associated with poor tumor control .", "sentence_id": 0}
+{"abstract_id": "24452791", "label": "objective", "text": "It was previously observed that accelerated radiotherapy combined with carbogen breathing and nicotinamide ( ARCON ) can correct this adverse outcome in patients with head and neck cancer .", "sentence_id": 1}
+{"abstract_id": "24452791", "label": "objective", "text": "The purpose of this study was to validate this observation based on data from a randomized trial .", "sentence_id": 2}
+{"abstract_id": "24452791", "label": "methods", "text": "Of @ patients with cT@-@ laryngeal cancer , @ were randomly assigned to accelerated radiotherapy and @ to ARCON .", "sentence_id": 3}
+{"abstract_id": "24452791", "label": "methods", "text": "Hemoglobin levels , measured before treatment , were defined as low when < @ mmol/L for women and < @ mmol/L for men .", "sentence_id": 4}
+{"abstract_id": "24452791", "label": "methods", "text": "The hypoxia marker pimonidazole was used to assess the oxygenation status in tumor biopsies .", "sentence_id": 5}
+{"abstract_id": "24452791", "label": "methods", "text": "Data were analyzed @ years after inclusion of the last patient .", "sentence_id": 6}
+{"abstract_id": "24452791", "label": "results", "text": "Pretreatment hemoglobin levels were available and below normal in @ of @ ( @ % ) accelerated radiotherapy and @ of @ ( @ % ) ARCON patients .", "sentence_id": 7}
+{"abstract_id": "24452791", "label": "results", "text": "In patients with normal pretreatment , hemoglobin levels treatment with ARCON had no significant effect on @-year loco-regional control ( LRC , @ % versus @ % ; P = @ ) and disease-free survival ( DFS , @ % vs. @ % ; P = @ ) compared with accelerated radiotherapy .", "sentence_id": 8}
+{"abstract_id": "24452791", "label": "results", "text": "However , in patients with low pretreatment , hemoglobin levels ARCON significantly improved @-year LRC ( @ % vs. @ % ; P = @ ) and DFS ( @ % vs. @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24452791", "label": "results", "text": "In multivariate analysis including other prognostic factors , pretreatment hemoglobin remained prognostic for LRC and DFS in the accelerated radiotherapy treatment arm .", "sentence_id": 10}
+{"abstract_id": "24452791", "label": "results", "text": "No correlation between pretreatment hemoglobin levels and pimonidazole uptake was observed .", "sentence_id": 11}
+{"abstract_id": "24452791", "label": "conclusions", "text": "Results from the randomized phase III trial support previous observations that ARCON has the potential to correct the poor outcome of cancer patients with anemia ( ClinicalTrials.gov number , NCT@ ) .", "sentence_id": 12}
+{"abstract_id": "25842726", "label": "objective", "text": "To investigate the effect of different heat-stimulating time lengths on lower back pain .", "sentence_id": 0}
+{"abstract_id": "25842726", "label": "methods", "text": "Forty participants were randomly assigned to four groups of various heating time lengths .", "sentence_id": 1}
+{"abstract_id": "25842726", "label": "methods", "text": "The short heating time length group ( SL ) , moderate heating time length group ( ML ) , and long heating time length group ( LL ) respectively received @ , @ , and @ min of moxibustion therapy stimulating the acupoint Guanyuan ( CV @ ) .", "sentence_id": 2}
+{"abstract_id": "25842726", "label": "methods", "text": "The conventional acupuncture group ( CA ) received needle acupuncture treatment as a control group .", "sentence_id": 3}
+{"abstract_id": "25842726", "label": "methods", "text": "The participants were treated continuously over a @-week treatment period for a total of @ sessions , with five sessions given per week .", "sentence_id": 4}
+{"abstract_id": "25842726", "label": "methods", "text": "Participants were assessed weekly by blinded assessors , using the visual analogue scale ( VAS ) and Roland Morris Questionnaire ( RMQ ) .", "sentence_id": 5}
+{"abstract_id": "25842726", "label": "results", "text": "The VAS and RMQ scores reduced in all four groups during treatment .", "sentence_id": 6}
+{"abstract_id": "25842726", "label": "results", "text": "There were significant differences in VAS scores ( P < @ ) and RMQ scores ( P < @ ) between before treatment and after @ weeks of treatment in the LL group .", "sentence_id": 7}
+{"abstract_id": "25842726", "label": "results", "text": "After treatment , the LL group reported significantly lower VAS scores compared with the CA group , ML group , and SL group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25842726", "label": "conclusions", "text": "The long and moderate lengths of heat-stimulating time of @ and @ min may be more effective for relieving lower back pain than that of short stimulating time lengths .", "sentence_id": 9}
+{"abstract_id": "24687921", "label": "objective", "text": "In a recent phase II study of onartuzumab ( MetMAb ) , patients whose non-small cell lung cancer ( NSCLC ) tissue scored as positive for MET protein by immunohistochemistry ( IHC ) experienced a significant benefit with onartuzumab plus erlotinib ( O+E ) versus erlotinib .", "sentence_id": 0}
+{"abstract_id": "24687921", "label": "objective", "text": "We describe development and validation of a standardized MET IHC assay and , retrospectively , evaluate multiple biomarkers as predictors of patient benefit .", "sentence_id": 1}
+{"abstract_id": "24687921", "label": "methods", "text": "Biomarkers related to MET and/or EGF receptor ( EGFR ) signaling were measured by IHC , FISH , quantitative reverse transcription PCR , mutation detection techniques , and ELISA .", "sentence_id": 2}
+{"abstract_id": "24687921", "label": "results", "text": "A positive correlation between IHC , Western blotting , and MET mRNA expression was observed in NSCLC cell lines/tissues .", "sentence_id": 3}
+{"abstract_id": "24687921", "label": "results", "text": "An IHC scoring system of MET expression taking proportional and intensity-based thresholds into consideration was applied in an analysis of the phase II study and resulted in the best differentiation of outcomes .", "sentence_id": 4}
+{"abstract_id": "24687921", "label": "results", "text": "Further analyses revealed a nonsignificant overall survival ( OS ) improvement with O+E in patients with high MET copy number ( mean@ copies/cell by FISH ) ; however , benefit was maintained in `` MET IHC-positive '' / MET FISH-negative patients ( HR , @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24687921", "label": "results", "text": "MET , EGFR , amphiregulin , epiregulin , or HGF mRNA expression did not predict a significant benefit with onartuzumab ; a nonsignificant OS improvement was observed in patients with high tumor MET mRNA levels ( HR , @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24687921", "label": "results", "text": "Patients with low baseline plasma hepatocyte growth factor ( HGF ) exhibited an HR for OS of @ ( P = @ ) in favor of onartuzumab treatment .", "sentence_id": 7}
+{"abstract_id": "24687921", "label": "conclusions", "text": "MET IHC remains the most robust predictor of OS and progression-free survival benefit from O+E relative to all examined exploratory markers .", "sentence_id": 8}
+{"abstract_id": "24641883", "label": "objective", "text": "Energy deficit ( ED ) diminishes fat-free mass ( FFM ) with concomitant reductions in anabolic hormone secretion .", "sentence_id": 0}
+{"abstract_id": "24641883", "label": "objective", "text": "A modest increase in protein to recommended dietary allowance ( RDA ) levels during ED minimally attenuates decrements in insulin-like growth factor-I ( IGF-I ) .", "sentence_id": 1}
+{"abstract_id": "24641883", "label": "objective", "text": "The impact of dietary protein above the RDA on circulating anabolic hormones and their relationships with FFM in response to ED are not well described .", "sentence_id": 2}
+{"abstract_id": "24641883", "label": "methods", "text": "Thirty-three adults were assigned diets providing protein at @ ( RDA ) , @ ( @-RDA ) , and @ ( @-RDA ) g/kg/d for @days .", "sentence_id": 3}
+{"abstract_id": "24641883", "label": "methods", "text": "Testosterone , sex-hormone binding globulin ( SHBG ) and IGF-I system components were assessed after a @-day period of weight-maintenance ( WM ) and after a @-day period of ED ( @ % ) achieved by an increase in energy expenditure and decreased energy intake .", "sentence_id": 4}
+{"abstract_id": "24641883", "label": "methods", "text": "Associations between the change in FFM and anabolic hormone levels were determined .", "sentence_id": 5}
+{"abstract_id": "24641883", "label": "results", "text": "As compared to WM and regardless of dietary protein intake , total and free testosterone , total IGF-I , and acid-labile subunit decreased ( P < @ ) , whereas SHBG and IGF binding proteins-@ , -@ , and -@ increased ( P < @ ) during ED .", "sentence_id": 6}
+{"abstract_id": "24641883", "label": "results", "text": "There were no energy-by-protein interactions on any hormones or IGF-I system components measured .", "sentence_id": 7}
+{"abstract_id": "24641883", "label": "results", "text": "Changes in FFM in response to ED were negatively associated with acid-labile subunit ( ALS ) ( r = -@ , P < @ ) in @-RDA ; however , no other relationships were observed .", "sentence_id": 8}
+{"abstract_id": "24641883", "label": "conclusions", "text": "Consuming a high protein diet does not impact the androgenic and IGF-I system response to ED .", "sentence_id": 9}
+{"abstract_id": "24641883", "label": "conclusions", "text": "These data suggest that the protective effects of high protein diets on FFM during ED are likely not influenced by anabolic hormone concentrations .", "sentence_id": 10}
+{"abstract_id": "24330449", "label": "background", "text": "After renal transplantation , postoperative pain is usually mild to moderate .", "sentence_id": 0}
+{"abstract_id": "24330449", "label": "background", "text": "Postoperative pain is a concern and administration of systemic analgesic may be difficult because of underlying co-morbidities and variable responses of the graft .", "sentence_id": 1}
+{"abstract_id": "24330449", "label": "background", "text": "The transversus abdominis plane ( TAP ) block is one of the different approaches for postoperative pain relief following abdominal surgeries .", "sentence_id": 2}
+{"abstract_id": "24330449", "label": "background", "text": "We evaluated analgesic efficacy of TAP block on early postoperative pain by numeric rating scale ( NRS ) and morphine consumption during the first @ hours after kidney transplantation .", "sentence_id": 3}
+{"abstract_id": "24330449", "label": "methods", "text": "Forty-four patients , scheduled as kidney recipients were randomized into two equal groups and were anesthetized with the same technique .", "sentence_id": 4}
+{"abstract_id": "24330449", "label": "methods", "text": "After the induction of anesthesia , @mL of @ % Bupivacaine plus @/ml epinephrine or saline was deposited into the transversus abdominis neuro-fascial plane on the side of surgery by ultrasound guide .", "sentence_id": 5}
+{"abstract_id": "24330449", "label": "methods", "text": "Each patient was assessed by a blinded investigator using NRS at @st , @th , @th , @th , and @th hour postoperatively .", "sentence_id": 6}
+{"abstract_id": "24330449", "label": "results", "text": "Demographic data were not significantly different between the study groups .", "sentence_id": 7}
+{"abstract_id": "24330449", "label": "results", "text": "There was significant difference in median of NRS score measured at all time points in the study groups ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24330449", "label": "results", "text": "The @-hour morphine consumption ( meanSD ) was @ mg in bupivacaine group compared with @ mg in the saline group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24330449", "label": "results", "text": "There was statistically significant reduction in intraoperative fentanyl consumption in the TAP group @g compared to the control group @g ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24330449", "label": "results", "text": "In study group @ patients and in control group @ patients received morphine titration for pain relief ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24330449", "label": "results", "text": "There was no complication in the study groups related to nerve block .", "sentence_id": 12}
+{"abstract_id": "24330449", "label": "results", "text": "Only two patients in saline group had nausea ( P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24330449", "label": "results", "text": "None of our patients received any other oral or IV rescue medication .", "sentence_id": 14}
+{"abstract_id": "24330449", "label": "conclusions", "text": "Ultrasound TAP block can reduce postrenal transplantation pain and the amount of opioids consumption intraoperatively and during the first @ hours after surgery in kidney recipients .", "sentence_id": 15}
+{"abstract_id": "24999963", "label": "background", "text": "Elevated symmetric dimethylarginine ( SDMA ) has been shown to predict cardiovascular events and all cause mortality in diverse populations .", "sentence_id": 0}
+{"abstract_id": "24999963", "label": "background", "text": "The potential role of SDMA as a risk marker in renal transplant recipients ( RTR ) has not been investigated .", "sentence_id": 1}
+{"abstract_id": "24999963", "label": "methods", "text": "We analyzed SDMA in the placebo arm of the Assessment of Lescol in Renal Transplantation study , a randomized controlled trial of fluvastatin in RTR .", "sentence_id": 2}
+{"abstract_id": "24999963", "label": "methods", "text": "Mean follow-up was @ years .", "sentence_id": 3}
+{"abstract_id": "24999963", "label": "methods", "text": "Patients were grouped into quartiles based on SDMA levels at study inclusion .", "sentence_id": 4}
+{"abstract_id": "24999963", "label": "methods", "text": "Relationships between SDMA and traditional risk factors for graft function and all-cause mortality were analyzed in @ RTR using univariate and multivariate survival analyses .", "sentence_id": 5}
+{"abstract_id": "24999963", "label": "results", "text": "In univariate analysis , SDMA was significantly associated with renal graft loss , all-cause death , and major cardiovascular events .", "sentence_id": 6}
+{"abstract_id": "24999963", "label": "results", "text": "After adjustment for established risk factors including estimated glomerular filtration rate , an elevated SDMA-level ( @th quartile , > @ mol/L ) was associated with renal graft loss ; hazard ratio ( HR ) , @ ; @ % confidence interval ( CI ) , @-@ @ ; P = @ , compared to the @st quartile .", "sentence_id": 7}
+{"abstract_id": "24999963", "label": "results", "text": "Similarly , SDMA in the @th quartile was independently associated with all-cause mortality ( HR , @ ; @ % CI , @-@ @ ; P < @ ) , and there was a strong borderline significant trend for an association with cardiovascular mortality ( HR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24999963", "label": "conclusions", "text": "In stable RTR , an elevated SDMA level is independently associated with increased risk of all-cause mortality and renal graft loss .", "sentence_id": 9}
+{"abstract_id": "25112307", "label": "background", "text": "Medication-overuse headache ( MOH ) is common in the general population .", "sentence_id": 0}
+{"abstract_id": "25112307", "label": "background", "text": "We investigated effectiveness of brief intervention ( BI ) for achieving drug withdrawal in primary care patients with MOH .", "sentence_id": 1}
+{"abstract_id": "25112307", "label": "methods", "text": "The study was double-blind , pragmatic and cluster-randomised controlled .", "sentence_id": 2}
+{"abstract_id": "25112307", "label": "methods", "text": "A total of @,@ patients ( age @-@ ) from @ general practitioners ( GPs ) were screened for MOH .", "sentence_id": 3}
+{"abstract_id": "25112307", "label": "methods", "text": "GPs defined clusters and were randomised to receive BI training ( @ GPs ) or to continue business as usual ( BAU ; @ GPs ) .", "sentence_id": 4}
+{"abstract_id": "25112307", "label": "methods", "text": "The Severity of Dependence Scale was applied as a part of the BI .", "sentence_id": 5}
+{"abstract_id": "25112307", "label": "methods", "text": "BI involved feedback about individual risk of MOH and how to reduce overuse .", "sentence_id": 6}
+{"abstract_id": "25112307", "label": "methods", "text": "Primary outcome measures were reduction in medication and headache days/month @ months after the intervention and were assessed by a blinded clinical investigator .", "sentence_id": 7}
+{"abstract_id": "25112307", "label": "results", "text": "@ % responded to the postal screening questionnaire , and @ % screened positive for MOH .", "sentence_id": 8}
+{"abstract_id": "25112307", "label": "results", "text": "A random selection of up to three patients with MOH from each GP were invited ( @ patients ) , @ patients were randomised and @ patients included into the study .", "sentence_id": 9}
+{"abstract_id": "25112307", "label": "results", "text": "BI was significantly better than BAU for the primary outcomes ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25112307", "label": "results", "text": "Headache and medication days were reduced by @ and @ ( @ % CI @ to @ and @ to @ ) days/month in the BI compared with the BAU group .", "sentence_id": 11}
+{"abstract_id": "25112307", "label": "results", "text": "Chronic headache resolved in @ % of the BI and @ % of the BAU group .", "sentence_id": 12}
+{"abstract_id": "25112307", "label": "conclusions", "text": "The BI method provides GPs with a simple and effective instrument that reduces medication-overuse and headache frequency in patients with MOH .", "sentence_id": 13}
+{"abstract_id": "25341169", "label": "objective", "text": "The aim of this study was to determine both the value of gadolinium-enhanced MRI in children with suspected acute appendicitis and the best sequences for detecting acute appendicitis , to thereby decrease imaging time .", "sentence_id": 0}
+{"abstract_id": "25341169", "label": "methods", "text": "This was a retrospective review of pediatric patients with suspected appendicitis who had undergone MRI at our institution between @ and @ after an indeterminate ultrasound examination .", "sentence_id": 1}
+{"abstract_id": "25341169", "label": "methods", "text": "MRI examinations included T@-weighted unenhanced and contrast-enhanced , T@-weighted , and balanced steady-state free precession ( SSFP ) sequences in axial and coronal planes .", "sentence_id": 2}
+{"abstract_id": "25341169", "label": "methods", "text": "Sequences were reviewed together and individually by five radiologists who were blinded to the final diagnosis .", "sentence_id": 3}
+{"abstract_id": "25341169", "label": "methods", "text": "Radiologists were asked to score their confidence of appendicitis diagnosis using a @-point scale .", "sentence_id": 4}
+{"abstract_id": "25341169", "label": "methods", "text": "The diagnostic performance of each MR sequence was obtained by comparing the mean area under the curve ( AUC ) using receiver operating characteristic ( ROC ) analysis .", "sentence_id": 5}
+{"abstract_id": "25341169", "label": "results", "text": "A total of @ patients with clinically suspected appendicitis were included , of whom @ received a diagnosis of appendicitis .", "sentence_id": 6}
+{"abstract_id": "25341169", "label": "results", "text": "The mean AUCs for reviewing all sequences together , contrast-enhanced sequences alone , T@-weighted sequences alone , and balanced SSFP alone were @ , @ , @ , and @ , respectively .", "sentence_id": 7}
+{"abstract_id": "25341169", "label": "results", "text": "No significant difference was observed between reviewing all sequences together versus contrast-enhanced sequences alone ( p = @ ) and T@-weighted sequences alone ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25341169", "label": "results", "text": "A significant difference was observed between contrast-enhanced sequences and balanced SSFP ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25341169", "label": "conclusions", "text": "Gadolinium-enhanced images and T@-weighted images are most helpful in the assessment of acute appendicitis in the pediatric population .", "sentence_id": 10}
+{"abstract_id": "25341169", "label": "conclusions", "text": "These findings have led to protocol modifications that have reduced imaging time .", "sentence_id": 11}
+{"abstract_id": "24753225", "label": "background", "text": "There is an urgent need for more effective treatments for major depressive disorder ( MDD ) .", "sentence_id": 0}
+{"abstract_id": "24753225", "label": "background", "text": "As understanding of the cognitive and affective neuroscience underlying psychiatric disorders expands , so do opportunities to develop interventions that capitalize on the capacity for brain plasticity .", "sentence_id": 1}
+{"abstract_id": "24753225", "label": "background", "text": "Cognitive training is one such strategy .", "sentence_id": 2}
+{"abstract_id": "24753225", "label": "background", "text": "In this article , we report a proof-of-concept study of a novel cognitive-emotional training exercise designed to enhance cognitive control for emotional information processing and targeting components of the neural networks that have been implicated in MDD .", "sentence_id": 3}
+{"abstract_id": "24753225", "label": "methods", "text": "Twenty-one participants with MDD in a current episode were randomly assigned to one of the two treatment conditions : @ participating in a cognitive-emotional training paradigm ( emotional faces memory task ( EFMT ) ) involving eight sessions over @ weeks , and @ participating in an active control condition ( control training , CT ) .", "sentence_id": 4}
+{"abstract_id": "24753225", "label": "methods", "text": "Assessments of MDD symptoms , negative affective bias in cognitive processing , and neurocognition ( attention and working memory ) were administered at baseline and after @ weeks .", "sentence_id": 5}
+{"abstract_id": "24753225", "label": "results", "text": "Participants in the EFMT group exhibited a greater reduction in MDD symptoms compared to the CT group , and @ of the @ EFMT participants achieved clinical response ( @ % reduction in symptoms ) .", "sentence_id": 6}
+{"abstract_id": "24753225", "label": "results", "text": "EFMT participants also exhibited changes in negative affective bias in the hypothesized direction whereas the CT participants did not .", "sentence_id": 7}
+{"abstract_id": "24753225", "label": "results", "text": "Both groups exhibited similar , small improvements in attention and working memory .", "sentence_id": 8}
+{"abstract_id": "24753225", "label": "conclusions", "text": "Cognitive-emotional training may represent a feasible and effective intervention strategy for MDD .", "sentence_id": 9}
+{"abstract_id": "24753225", "label": "conclusions", "text": "This proof-of-concept study highlights the need for future studies to fully understand the effectiveness , and mechanisms of effect , of these training strategies .", "sentence_id": 10}
+{"abstract_id": "24423077", "label": "background", "text": "Uncertainty exists regarding the optimal method to estimate glomerular filtration rate ( GFR ) for disease detection and monitoring .", "sentence_id": 0}
+{"abstract_id": "24423077", "label": "background", "text": "Widely used GFR estimates have not been validated in British ethnic minority populations .", "sentence_id": 1}
+{"abstract_id": "24423077", "label": "methods", "text": "Iohexol measured GFR will be the reference against which each estimating equation will be compared .", "sentence_id": 2}
+{"abstract_id": "24423077", "label": "methods", "text": "The estimating equations will be based upon serum creatinine and/or cystatin C.", "sentence_id": 3}
+{"abstract_id": "24423077", "label": "methods", "text": "The eGFR-C study has @ components : @ ) A prospective longitudinal cohort study of @ adults with stage @ chronic kidney disease followed for @ years with reference ( measured ) GFR and test ( estimated GFR -LSB- eGFR -RSB- and urinary albumin-to-creatinine ratio ) measurements at baseline and @ years .", "sentence_id": 4}
+{"abstract_id": "24423077", "label": "methods", "text": "Test measurements will also be undertaken every @ months .", "sentence_id": 5}
+{"abstract_id": "24423077", "label": "methods", "text": "The study population will include a representative sample of South-Asians and African-Caribbeans .", "sentence_id": 6}
+{"abstract_id": "24423077", "label": "methods", "text": "People with diabetes and proteinuria ( ACR @ mg/mmol ) will comprise @-@ % of the study cohort @ ) A sub-study of patterns of disease progression of @ people ( @ each of Caucasian , Asian and African-Caribbean origin ; in each case containing subjects at high and low risk of renal progression ) .", "sentence_id": 7}
+{"abstract_id": "24423077", "label": "methods", "text": "Additional reference GFR measurements will be undertaken after @ and @ years to enable a model of disease progression and error to be built @ ) A biological variability study to establish reference change values for reference and test measures @ ) A modelling study of the performance of monitoring strategies on detecting progression , utilising estimates of accuracy , patterns of disease progression and estimates of measurement error from studies @ ) , @ ) and @ ) @ ) A comprehensive cost database for each diagnostic approach will be developed to enable cost-effectiveness modelling of the optimal strategy.The performance of the estimating equations will be evaluated by assessing bias , precision and accuracy .", "sentence_id": 8}
+{"abstract_id": "24423077", "label": "methods", "text": "Data will be modelled as a linear function of time utilising all available ( maximum @ ) time points compared with the difference between baseline and final reference values .", "sentence_id": 9}
+{"abstract_id": "24423077", "label": "methods", "text": "The percentage of participants demonstrating large error with the respective estimating equations will be compared .", "sentence_id": 10}
+{"abstract_id": "24423077", "label": "methods", "text": "Predictive value of GFR estimates and albumin-to-creatinine ratio will be compared amongst subjects that do or do not show progressive kidney function decline .", "sentence_id": 11}
+{"abstract_id": "24423077", "label": "conclusions", "text": "The eGFR-C study will provide evidence to inform the optimal GFR estimate to be used in clinical practice .", "sentence_id": 12}
+{"abstract_id": "24277778", "label": "background", "text": "Cardiovascular disease ( CVD ) accounts for @ % of UK deaths .", "sentence_id": 0}
+{"abstract_id": "24277778", "label": "background", "text": "It is associated with modifiable lifestyle factors , including insufficient consumption of fruit and vegetables ( F&V ) .", "sentence_id": 1}
+{"abstract_id": "24277778", "label": "background", "text": "Lay health trainers ( LHTs ) offer practical support to help people develop healthier behaviour and lifestyles .", "sentence_id": 2}
+{"abstract_id": "24277778", "label": "background", "text": "Our two-group pilot randomized controlled trial ( RCT ) investigated the effectiveness of LHTs at promoting a heart-healthy lifestyle among adults with at least one risk factor for CVD to inform a full-scale RCT .", "sentence_id": 3}
+{"abstract_id": "24277778", "label": "methods", "text": "Eligible adults ( aged @-@ years ) , recruited from five practices serving deprived populations , were randomized to health information leaflets plus LHTs ' support for @ months ( n = @ ) versus health information leaflets alone ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24277778", "label": "results", "text": "We recruited @ participants , with @ % completing @ month follow-up .", "sentence_id": 5}
+{"abstract_id": "24277778", "label": "results", "text": "Both groups increased their self-reported F&V consumption and we found no evidence for LHTs ' support having significant added impact .", "sentence_id": 6}
+{"abstract_id": "24277778", "label": "results", "text": "Most participants were relatively less deprived , as were the LHTs we were able to recruit and train .", "sentence_id": 7}
+{"abstract_id": "24277778", "label": "conclusions", "text": "Our pilot demonstrated that an LHT 's RCT whilst feasible faces considerable challenges .", "sentence_id": 8}
+{"abstract_id": "24277778", "label": "conclusions", "text": "However , to justify growing investment in LHTs , any behaviour changes and sustained impact on those at greatest need should be demonstrated in an independently evaluated , robust , fully powered RCT .", "sentence_id": 9}
+{"abstract_id": "26152000", "label": "objective", "text": "To evaluate time-limited hydrotubation combined with clomiphene citrate as treatment for unexplained infertility .", "sentence_id": 0}
+{"abstract_id": "26152000", "label": "methods", "text": "In this unblinded , randomized controlled trial of patients who had unexplained infertility , @ patients were treated with time-limited hydrotubation ( saline , @ ml ; flushed within @ to @ seconds ) and clomphene citrate ( total , @ cycles ) and @ patients were treated with clomiphene citrate alone ( total , @ cycles ) .", "sentence_id": 1}
+{"abstract_id": "26152000", "label": "methods", "text": "All women underwent an ovulation induction protocol with clomiphene citrate ( @ mg/d orally for five days , from day @ to day @ of the cycle ) .", "sentence_id": 2}
+{"abstract_id": "26152000", "label": "methods", "text": "Hydrotubation was performed after detection of the dominant follicle .", "sentence_id": 3}
+{"abstract_id": "26152000", "label": "results", "text": "There were @ pregnancies in the @ patients ( @ % ) ( total , @ stimulated cycles ; @ % pregnancies per cycle ) .", "sentence_id": 4}
+{"abstract_id": "26152000", "label": "results", "text": "The frequency of clinical pregnancy per cycle was significantly greater in patients who were treated with hydrotubation and clomiphene citrate ( nine pregnancies per cycle -LSB- @ % -RSB- ) than those treated with clomiphene citrate alone ( two pregnancies per cycle -LSB- @ % -RSB- ; odds ratio , @ ; @ % confidence interval , @ to @ ; p @ ) .", "sentence_id": 5}
+{"abstract_id": "26152000", "label": "results", "text": "The frequency of pregnancy per patient ( total , clinical , or chemical ) was similar for the two treatment groups .", "sentence_id": 6}
+{"abstract_id": "26152000", "label": "results", "text": "The frequency of live birth or abortion per cycle or patient was similar between the two treatment groups .", "sentence_id": 7}
+{"abstract_id": "26152000", "label": "conclusions", "text": "Time-limited hydrotubation and clomiphene citrate may increase the frequency of clinical pregnancy per cycle in women who have unexplained infertility .", "sentence_id": 8}
+{"abstract_id": "24338756", "label": "background", "text": "Although colonoscopy is the standard procedure in the diagnosis of colorectal neoplasia , a significant number of clinical relevant lesions may be missed even by experienced endoscopists using current technology .", "sentence_id": 0}
+{"abstract_id": "24338756", "label": "background", "text": "A transparent cap mounted at the tip of a colonoscope may be an easy way to extend the visual field during colonoscopy and may improve the detection rate of mucosal lesions .", "sentence_id": 1}
+{"abstract_id": "24338756", "label": "methods", "text": "The significance of cap assisted ( CAC ) vs. conventional colonoscopy ( CC ) on polyp detection rate was evaluated in a prospective randomized controlled trial in @ patients .", "sentence_id": 2}
+{"abstract_id": "24338756", "label": "results", "text": "CC and CAC detected polyps in @ % and @ , not significantly different .", "sentence_id": 3}
+{"abstract_id": "24338756", "label": "results", "text": "There was also no significant difference between CAC and CC according to age , sex , indication for colonoscopy , diverticulosis , sedation , bowel cleansing , withdrawal time , time/number of attempts to intubate the cecal walve , number , localization , size or histology of polyps , .", "sentence_id": 4}
+{"abstract_id": "24338756", "label": "results", "text": "However , the time to reach the cecal floor and the overall time of colonoscopy were significantly lower for CAC ( @ minute ) .", "sentence_id": 5}
+{"abstract_id": "24338756", "label": "conclusions", "text": "CAC was without clinical impact on polyp detection rate or performance of colonoscopy .", "sentence_id": 6}
+{"abstract_id": "25116294", "label": "objective", "text": "Although most intensive care unit ( ICU ) admissions originate in the emergency department ( ED ) , a substantial number of admissions arrive from hospital wards .", "sentence_id": 0}
+{"abstract_id": "25116294", "label": "objective", "text": "Patients transferred from the hospital ward often share clinical characteristics with those admitted from the ED , but family expectations may differ .", "sentence_id": 1}
+{"abstract_id": "25116294", "label": "objective", "text": "An understanding of the impact of ICU admission source on family perceptions of end-of-life care may help improve patient and family outcomes by identifying those at risk for poor outcomes .", "sentence_id": 2}
+{"abstract_id": "25116294", "label": "methods", "text": "This was a cohort study of patients with chronic illness and acute respiratory failure requiring mechanical ventilation who died after admission to an ICU in any of the @ participating hospitals in the Seattle-Tacoma area between @ and @ ( n = @,@ ) .", "sentence_id": 3}
+{"abstract_id": "25116294", "label": "methods", "text": "Using regression models adjusted for hospital site and patient - , nurse - and family-level characteristics , we examined associations between ICU admission source ( hospital ward vs. ED ) and ( @ ) family ratings of satisfaction with ICU care ; ( @ ) family and nurse ratings of quality of dying ; ( @ ) chart-based indicators of palliative care .", "sentence_id": 4}
+{"abstract_id": "25116294", "label": "results", "text": "Admission from the hospital ward was associated with lower family ratings of quality of dying -LSB- -@ , @ % confidence interval ( CI ) -@ , -@ , p = @ -RSB- and satisfaction ( total score -@ , @ % CI -@ , -@ , p = @ ; satisfaction with care domain score -@ , @ % CI -@ , -@ , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25116294", "label": "results", "text": "Nurses did not report differences in quality of dying .", "sentence_id": 6}
+{"abstract_id": "25116294", "label": "results", "text": "Patients from hospital wards were less likely to have family conferences -LSB- odds ratio ( OR ) @ , @ % CI @ , @ , p = @ -RSB- or discussion of prognosis in the first @ h after ICU admission ( OR @ , @ % CI @ , @ , p = @ ) but were more likely to receive spiritual care ( OR @ , @ % CI @ , @ , p = @ ) or have life support withdrawn ( OR @ , @ % CI @ , @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25116294", "label": "conclusions", "text": "Admission from the hospital ward is associated with family perceptions of a lower quality of dying and less satisfaction with ICU care .", "sentence_id": 8}
+{"abstract_id": "25116294", "label": "conclusions", "text": "Differences in receipt of palliative care suggest that family of patients from the hospital ward receive less communication .", "sentence_id": 9}
+{"abstract_id": "25116294", "label": "conclusions", "text": "Nurse ratings of quality of dying did not significantly differ by ICU admission source , suggesting dissimilarities between family and nurse perspectives .", "sentence_id": 10}
+{"abstract_id": "25116294", "label": "conclusions", "text": "This study identifies a patient population at risk for poor quality palliative and end-of-life care .", "sentence_id": 11}
+{"abstract_id": "25116294", "label": "conclusions", "text": "Future studies are needed to identify interventions to improve care for patients who deteriorate on the wards following hospital admission .", "sentence_id": 12}
+{"abstract_id": "24232445", "label": "objective", "text": "Hypericum perforatum ( St John 's wort ) is used to treat depression , but the effectiveness has not been established .", "sentence_id": 0}
+{"abstract_id": "24232445", "label": "objective", "text": "Recent guidelines described the analysis of clinical trials with missing data , inspiring the reanalysis of this trial using proper missing data methods .", "sentence_id": 1}
+{"abstract_id": "24232445", "label": "objective", "text": "The objective was to determine whether hypericum was superior to placebo in treating major depression .", "sentence_id": 2}
+{"abstract_id": "24232445", "label": "methods", "text": "A placebo-controlled , randomized clinical trial was conducted for @ weeks to determine the effectiveness of hypericum or sertraline in reducing depression , measured using the Hamilton depression scale.We performed sensitivity analyses under different assumptions about the missing data process .", "sentence_id": 3}
+{"abstract_id": "24232445", "label": "results", "text": "Three hundred forty participants were randomized , with @ % lost to follow-up .", "sentence_id": 4}
+{"abstract_id": "24232445", "label": "results", "text": "The missing data mechanism was not missing completely at random .", "sentence_id": 5}
+{"abstract_id": "24232445", "label": "results", "text": "Under missing at random assumptions , some sensitivity analyses found no difference between either treatment armand placebo , while some sensitivity analyses found a significant difference from baseline to week @ between sertraline and placebo ( -@ , @ % credible interval -LSB- -@ ; -@ -RSB- ) , but not between hypericum and placebo ( @ , -LSB- -@ ; @ -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "24232445", "label": "results", "text": "The results were similar when the missing data process was assumed to be missing not at random .", "sentence_id": 7}
+{"abstract_id": "24232445", "label": "conclusions", "text": "There is no difference between hypericum and placebo , regardless of the assumption about the missing data process .", "sentence_id": 8}
+{"abstract_id": "24232445", "label": "conclusions", "text": "There is a significant difference between sertraline and placebo with some statistical-methods used .", "sentence_id": 9}
+{"abstract_id": "24232445", "label": "conclusions", "text": "It is important to conduct an analysis that takes account of missing data using valid statistically principled methods .", "sentence_id": 10}
+{"abstract_id": "24232445", "label": "conclusions", "text": "The assumptions about the missing data process could influence the results .", "sentence_id": 11}
+{"abstract_id": "24875033", "label": "background", "text": "An important factor in the functional results after total knee arthroplasty is the achieved maximal flexion .", "sentence_id": 0}
+{"abstract_id": "24875033", "label": "background", "text": "The main purpose of this study was to compare the maximal knee flexion one year after surgery in patients who received either the bicruciate substituting knee system or the conventional posterior stabilized system .", "sentence_id": 1}
+{"abstract_id": "24875033", "label": "methods", "text": "In a prospective randomized controlled trial , @ patients presenting with osteoarthritis received the bicruciate substituting or the conventional posterior stabilized prosthesis .", "sentence_id": 2}
+{"abstract_id": "24875033", "label": "methods", "text": "The primary outcome was the maximum flexion angle at one year postoperatively on a lateral radiograph made with the supine patient using manual force to bend the knee .", "sentence_id": 3}
+{"abstract_id": "24875033", "label": "methods", "text": "Secondary outcomes were active flexion ( lying and standing ) , the Knee Society Score , the Patella Scoring System score , the University of California Los Angeles score , the number and type of adverse device effects , and visual analog scale satisfaction up to two years postoperatively .", "sentence_id": 4}
+{"abstract_id": "24875033", "label": "methods", "text": "The outcome measures of both groups were compared using one-sided t tests and non-parametric alternatives , with a significance level of p < @ .", "sentence_id": 5}
+{"abstract_id": "24875033", "label": "results", "text": "No significant differences between the two groups were observed in maximal flexion on radiographs and in active flexion at baseline .", "sentence_id": 6}
+{"abstract_id": "24875033", "label": "results", "text": "The median maximal flexion on radiographs was @ ( range , @ to @ ) for the bicruciate substituting group and @ ( range , @ to @ ) for the conventional posterior stabilized group .", "sentence_id": 7}
+{"abstract_id": "24875033", "label": "results", "text": "The two groups showed comparable two-year results with respect to the Knee Society Score , the Patella Scoring System , the University of California Los Angeles score , and visual analog scale satisfaction .", "sentence_id": 8}
+{"abstract_id": "24875033", "label": "results", "text": "In the bicruciate substituting group , forty-one adverse device effects in twenty-six patients were reported , including three total system revisions and fourteen manipulations under anesthesia , compared with the conventional posterior stabilized group , in which sixteen adverse device effects were observed in thirteen patients , including six manipulations under anesthesia ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24875033", "label": "conclusions", "text": "Patients who receive a bicruciate substituting system compared with those who receive a conventional posterior stabilized system have comparable knee flexion characteristics and clinical and functional outcomes but more complications by two years after total knee arthroplasty .", "sentence_id": 10}
+{"abstract_id": "24875033", "label": "methods", "text": "Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence .", "sentence_id": 11}
+{"abstract_id": "25693004", "label": "background", "text": "Angiotensin II receptor blockers ( ARBs ) is a well-tolerated class of antihypertensive agents , exhibiting effective antihypertensive and cardiovascular protective function .", "sentence_id": 0}
+{"abstract_id": "25693004", "label": "background", "text": "The objective of the study was to examine the efficacy and safety of Allisartan Isoproxil , a newly developed , selective , nonpeptide blocker of the angiotensin II type @ receptor ( AT@R ) , in essential hypertensive patients at low-medium risk .", "sentence_id": 1}
+{"abstract_id": "25693004", "label": "results", "text": "A Phase II prospective , randomized , double-blind , placebo-controlled , multicenter trial comparing Allisartan Isoproxil @mg versus placebo was conducted in essential hypertensive patients at low-medium risk at @ sites in China .", "sentence_id": 2}
+{"abstract_id": "25693004", "label": "results", "text": "After a @-week placebo baseline period , @ patients received once-daily treatment with Allisartan Isoproxil @mg or placebo randomly for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25693004", "label": "results", "text": "Systolic/diastolic blood pressure ( SBP/DBP ) was measured at week @ , @ and @ .", "sentence_id": 4}
+{"abstract_id": "25693004", "label": "results", "text": "By the end of treatment , mean reductions from baseline of SBP and DBP in Allisartan Isoproxil and placebo groups were @ / @ and @ / @ mmHg , respectively ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25693004", "label": "results", "text": "The rate of effective blood pressure control in Allisartan Isoproxil group was significantly higher than in placebo group at week @ ( @ % vs @ % , P < @ ) and week @ ( @ % vs @ % , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25693004", "label": "results", "text": "In terms of safety and tolerability , there were no report of death and serious adverse event ( SAE ) in all subjects .", "sentence_id": 7}
+{"abstract_id": "25693004", "label": "results", "text": "There was no difference of frequency between two groups in adverse event ( AE ) and adverse drug reaction ( ADR ) ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "25693004", "label": "results", "text": "No one withdraw because of an ADR in two groups .", "sentence_id": 9}
+{"abstract_id": "25693004", "label": "results", "text": "@ patients received additional @ weeks treatment with Allisartan Isoproxil and @ of them completed the study .", "sentence_id": 10}
+{"abstract_id": "25693004", "label": "results", "text": "The rate of effective BP control kept up to @ % since week @ .", "sentence_id": 11}
+{"abstract_id": "25693004", "label": "results", "text": "No significant clinical change was observed and ADRs were generally mild or moderate during the long-term study .", "sentence_id": 12}
+{"abstract_id": "25693004", "label": "conclusions", "text": "Allisartan Isoproxil @mg was effective and safe for essential hypertension patients at low-medium risk .", "sentence_id": 13}
+{"abstract_id": "24885673", "label": "background", "text": "Bipolar I disorder ( BD-I ) is a chronic mental illness characterized by the presence of one or more manic episodes , or both depressive and manic episodes , usually separated by asymptomatic intervals .", "sentence_id": 0}
+{"abstract_id": "24885673", "label": "background", "text": "Pharmacists can contribute to the management of BD-I , mainly with the use of effective and safe drugs , and improve the patient 's life quality through pharmaceutical care .", "sentence_id": 1}
+{"abstract_id": "24885673", "label": "background", "text": "Some studies have shown the effect of pharmaceutical care in the achievement of therapeutic goals in different illnesses ; however , to our knowledge , there is a lack of randomized controlled trials designed to assess the effect of pharmacist intervention in patients with BD .", "sentence_id": 2}
+{"abstract_id": "24885673", "label": "background", "text": "The aim of this study is to assess the effectiveness of the Dader Method for pharmaceutical care in patients with BD-I .", "sentence_id": 3}
+{"abstract_id": "24885673", "label": "methods", "text": "Randomized , controlled , prospective , single-center clinical trial with duration of @months will be performed to compare the effect of Dader Method of pharmaceutical care with the usual care process of patients in a psychiatric clinic .", "sentence_id": 4}
+{"abstract_id": "24885673", "label": "methods", "text": "Patients diagnosed with BD-I aged between @ and @years who have been discharged or referred from outpatients service of the San Juan de Dios Clinic ( Antioquia , Colombia ) will be included .", "sentence_id": 5}
+{"abstract_id": "24885673", "label": "methods", "text": "Patients will be randomized into the intervention group who will receive pharmaceutical care provided by pharmacists working in collaboration with psychiatrists , or into the control group who will receive usual care and verbal-written counseling regarding BD .", "sentence_id": 6}
+{"abstract_id": "24885673", "label": "methods", "text": "Study outcomes will be assessed at baseline and at @ , @ , @ , and @months after randomization .", "sentence_id": 7}
+{"abstract_id": "24885673", "label": "methods", "text": "The primary outcome will be to measure the number of hospitalizations , emergency service consultations , and unscheduled outpatient visits .", "sentence_id": 8}
+{"abstract_id": "24885673", "label": "methods", "text": "Effectiveness , safety , adherence , and quality of life will be assessed as secondary outcomes .", "sentence_id": 9}
+{"abstract_id": "24885673", "label": "methods", "text": "Statistical analyses will be performed using two-tailed McNemar tests , Pearson chi-square tests , and Student 's t-tests ; a P value < @ will be considered as statistically significant .", "sentence_id": 10}
+{"abstract_id": "24885673", "label": "conclusions", "text": "As far as we know , this is the first randomized controlled trial to assess the effect of the Dader Method for pharmaceutical care in patients with BD-I and it could generate valuable information and recommendations about the role of pharmacists in the improvement of therapeutic goals , solution of drug-related problems , and adherence .", "sentence_id": 11}
+{"abstract_id": "24915259", "label": "objective", "text": "The disease process leading to clinical type @ diabetes often starts during the first years of life .", "sentence_id": 0}
+{"abstract_id": "24915259", "label": "objective", "text": "Early exposure to complex dietary proteins may increase the risk of - cell autoimmunity in children at genetic risk for type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "24915259", "label": "objective", "text": "Extensively hydrolyzed formulas do not contain intact proteins .", "sentence_id": 2}
+{"abstract_id": "24915259", "label": "objective", "text": "To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated autoantibodies in young children .", "sentence_id": 3}
+{"abstract_id": "24915259", "label": "methods", "text": "A double-blind randomized clinical trial of @ infants with HLA-conferred disease susceptibility and a first-degree relative with type @ diabetes recruited from May @ to January @ in @ study centers in @ countries ; @ were randomized to be weaned to the extensively hydrolyzed casein formula and @ were randomized to be weaned to a conventional cows ' milk-based formula .", "sentence_id": 4}
+{"abstract_id": "24915259", "label": "methods", "text": "The participants were observed to April @ , @ .", "sentence_id": 5}
+{"abstract_id": "24915259", "label": "methods", "text": "The participants received either a casein hydrolysate or a conventional cows ' milk formula supplemented with @ % of the casein hydrolysate .", "sentence_id": 6}
+{"abstract_id": "24915259", "label": "results", "text": "AND MEASURES : Primary outcome was positivity for at least @ diabetes-associated autoantibodies out of @ analyzed .", "sentence_id": 7}
+{"abstract_id": "24915259", "label": "results", "text": "Autoantibodies to insulin , glutamic acid decarboxylase , and the insulinoma-associated-@ ( IA-@ ) molecule were analyzed using radiobinding assays and islet cell antibodies with immunofluorescence during a median observation period of @ years ( mean , @ years ) .", "sentence_id": 8}
+{"abstract_id": "24915259", "label": "results", "text": "The absolute risk of positivity for @ or more islet autoantibodies was @ % among those randomized to the casein hydrolysate formula ( n = @ ) vs @ % among those randomized to the conventional formula ( n = @ ) .", "sentence_id": 9}
+{"abstract_id": "24915259", "label": "results", "text": "The unadjusted hazard ratio for positivity for @ or more autoantibodies among those randomized to be weaned to the casein hydrolysate was @ ( @ % CI , @-@ @ ) , compared with those randomized to the conventional formula , while the hazard ratio adjusted for HLA risk , duration of breastfeeding , vitamin D use , study formula duration and consumption , and region was @ ( @ % CI , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24915259", "label": "results", "text": "There were no clinically significant differences in the rate of reported adverse events between the @ groups .", "sentence_id": 11}
+{"abstract_id": "24915259", "label": "conclusions", "text": "Among infants at risk for type @ diabetes , the use of a hydrolyzed formula , when compared with a conventional formula , did not reduce the incidence of diabetes-associated autoantibodies after @ years .", "sentence_id": 12}
+{"abstract_id": "24915259", "label": "conclusions", "text": "These findings do not support a benefit from hydrolyzed formula .", "sentence_id": 13}
+{"abstract_id": "24915259", "label": "conclusions", "text": "TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT@ .", "sentence_id": 14}
+{"abstract_id": "24502911", "label": "background", "text": "Postural control associated with self-paced movement is critical for balance in frail older adults .", "sentence_id": 0}
+{"abstract_id": "24502911", "label": "background", "text": "The present work aimed to investigate the effects of a @D virtual reality-based program on postural control associated with rapid arm movement in this population .", "sentence_id": 1}
+{"abstract_id": "24502911", "label": "methods", "text": "Participants in an upright standing position performed rapid arm-raising movements towards a target .", "sentence_id": 2}
+{"abstract_id": "24502911", "label": "methods", "text": "Practice-related changes were assessed by pre - and post-test comparisons of hand kinematics and centre-of-pressure ( CoP ) displacement parameters measured in a training group and a control group .", "sentence_id": 3}
+{"abstract_id": "24502911", "label": "methods", "text": "During these pre - and post-test sessions , patients have to reach towards yellow balls appearing on the screen , form a standardized upright position ( with @cm between the two malleoli ) .", "sentence_id": 4}
+{"abstract_id": "24502911", "label": "methods", "text": "Training group patients took part in six sessions of virtual game .", "sentence_id": 5}
+{"abstract_id": "24502911", "label": "methods", "text": "In this , patients were asked to reach their arm towards yellow balls appearing on the screen , from an upright position .", "sentence_id": 6}
+{"abstract_id": "24502911", "label": "results", "text": "After training , we observed improvements in arm movements and in the initial phase of CoP displacement , especially in the anticipatory postural adjustments .", "sentence_id": 7}
+{"abstract_id": "24502911", "label": "results", "text": "Learning curves for these two types of motor improvements showed different rates .", "sentence_id": 8}
+{"abstract_id": "24502911", "label": "results", "text": "These were continuous for the control of the arm movement , and discontinuous for the control of the CoP during the anticipatory postural adjustments .", "sentence_id": 9}
+{"abstract_id": "24502911", "label": "conclusions", "text": "These results suggest that some level of motor ( re ) - learning is maintained in frail patients with low functional reserves .", "sentence_id": 10}
+{"abstract_id": "24502911", "label": "conclusions", "text": "They also suggest that re-learning of anticipatory postural control ( i.e. motor prediction ) is less robust than explicit motor learning involved for the arm reaching .", "sentence_id": 11}
+{"abstract_id": "24502911", "label": "conclusions", "text": "This last point should encourage clinicians to extend the training course duration , even if reaching movement improvements seems acquired , in order to automate these anticipatory postural activities .", "sentence_id": 12}
+{"abstract_id": "24502911", "label": "conclusions", "text": "However , other studies should be done to measure the retention of these two types of learning on a longer-term period .", "sentence_id": 13}
+{"abstract_id": "24882173", "label": "background", "text": "The hippocampal volume is reduced in patients with major depression .", "sentence_id": 0}
+{"abstract_id": "24882173", "label": "background", "text": "Exercise leads to an increased hippocampal volume in schizophrenia and in healthy old adults .", "sentence_id": 1}
+{"abstract_id": "24882173", "label": "background", "text": "The effect of exercise on hippocampal volume is potentially mediated by brain derived neurotrophic factor ( BDNF ) , vascular endothelial growth factor ( VEGF ) , and insulin like growth factor @ ( IGF-@ ) .", "sentence_id": 2}
+{"abstract_id": "24882173", "label": "background", "text": "The aim of this trial was to assess the effect of an aerobic exercise intervention on hippocampal volume and serum BDNF , VEGF , and IGF-@ in patients with major depression .", "sentence_id": 3}
+{"abstract_id": "24882173", "label": "methods", "text": "Patients were randomized to an aerobic exercise intervention ( n = @ ) or a control condition ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24882173", "label": "methods", "text": "Both interventions consisted of three supervised sessions per week during a three months period .", "sentence_id": 5}
+{"abstract_id": "24882173", "label": "results", "text": "Post-intervention the increase in maximal oxygen uptake was @ ml/kg/min ( SD @ ) in the aerobic exercise group and @ ml/kg/min ( SD @ ) in the control group ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24882173", "label": "results", "text": "The hippocampal volume , BDNF , VEGF , or IGF-@ did not differ between the two groups .", "sentence_id": 7}
+{"abstract_id": "24882173", "label": "results", "text": "Post-hoc we found a positive association between change in hippocampal volume and verbal memory ( Rho = @ ; p = @ ) and change in hippocampal volume and depressive symptoms ( Rho = @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24882173", "label": "conclusions", "text": "Participation was low in both groups corresponding to an average participation of one session per week .", "sentence_id": 9}
+{"abstract_id": "24882173", "label": "conclusions", "text": "Despite a significant increase in maximal oxygen uptake , a pragmatic exercise intervention did not increase hippocampal volume or resting levels of neurotrophines in out-patients with mild to moderate major depression .", "sentence_id": 10}
+{"abstract_id": "24882173", "label": "conclusions", "text": "Trial identifier : ClinicalTrials.gov ( NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24726378", "label": "objective", "text": "Intra-lesional bony overgrowth ( BO ) identified during or following cartilage repair treatment is being frequently described through subjective reports focusing primarily on incidence .", "sentence_id": 0}
+{"abstract_id": "24726378", "label": "objective", "text": "Our objective was to quantify the exact volume of intra-lesional BO at @ months post-cartilage repair treatment , to determine if a correlation exists between the extent of BO and clinical outcomes , and to visualize and characterize the BO .", "sentence_id": 1}
+{"abstract_id": "24726378", "label": "methods", "text": "MRI scans were systematically obtained during a randomized clinical trial for cartilage repair ( Stanish etal. , @ ) that compared two microfracture-based treatments in @ patients .", "sentence_id": 2}
+{"abstract_id": "24726378", "label": "methods", "text": "Semi-automated morphological segmentation of pre-treatment , @ and @ months post-treatment scans utilizing a programmed anatomical atlas for all knee bone and cartilage structures permitted three-dimensional reconstruction , quantitative analysis , as well as qualitative characterization and artistic visualization ofBO .", "sentence_id": 3}
+{"abstract_id": "24726378", "label": "results", "text": "Limited intra-lesional BO representing only @ % of the original debrided cartilage lesion volume was found in @ patients with available MRIs at @ months .", "sentence_id": 4}
+{"abstract_id": "24726378", "label": "results", "text": "The majority ( @ % ) of patients had very little BO ( < @ % ) .", "sentence_id": 5}
+{"abstract_id": "24726378", "label": "results", "text": "Most occurrences of BO carried either spotty ( @ % ) or planar ( @ % ) morphological features , and the remaining balance ( @ % ) was qualitatively unobservable by eye .", "sentence_id": 6}
+{"abstract_id": "24726378", "label": "results", "text": "Pre-existing BO recurred at @ months in the same intra-lesional location in @ % of patients .", "sentence_id": 7}
+{"abstract_id": "24726378", "label": "results", "text": "No statistical correlations were found between BO and clinical outcomes .", "sentence_id": 8}
+{"abstract_id": "24726378", "label": "conclusions", "text": "Intra-lesional BO following microfracture-based treatments may not be as severe as previously believed , its incidence is partly explained by pre-existing conditions , and no relationship to clinical outcomes exists at @ months .", "sentence_id": 9}
+{"abstract_id": "24726378", "label": "conclusions", "text": "Morphologically , observable BO was categorized as comprising either spotty or planar bone .", "sentence_id": 10}
+{"abstract_id": "25151027", "label": "objective", "text": "To evaluate the role of post-surgical medical treatment with GnRHa in patients with DIE ( Deep Infiltrating Endometriosis ) that received complete or incomplete surgery laparoscopic excision .", "sentence_id": 0}
+{"abstract_id": "25151027", "label": "methods", "text": "Hundred fifty-nine patients with deep infiltrating endometriosis of the cul-de-sac and of the rectovaginal septum with pelvic pain undergoing laparoscopic surgery in academic tertiary-care medical center .", "sentence_id": 1}
+{"abstract_id": "25151027", "label": "methods", "text": "Eighty patients underwent complete laparoscopic excision of DIE ( Arm A ) while @ patients underwent incomplete surgery ( Arm B ) .", "sentence_id": 2}
+{"abstract_id": "25151027", "label": "methods", "text": "After surgery each surgical arm was randomized in two groups : no treatment groups @A -LSB- @ pts -RSB- and @B -LSB- @ pts -RSB- and GnRHa treatment for @ months groups @A -LSB- @ pts -RSB- and @B -LSB- @ pts -RSB- .", "sentence_id": 3}
+{"abstract_id": "25151027", "label": "methods", "text": "Pain recurrence and quality of life were evaluated in follow-up of @ months and compared between groups .", "sentence_id": 4}
+{"abstract_id": "25151027", "label": "results", "text": "No differences were observed between patient groups @A and @A .", "sentence_id": 5}
+{"abstract_id": "25151027", "label": "results", "text": "Groups @A , @A and @B obtained significantly lower pain scores than those achieved by the group @B undergoing incomplete surgical treatment and no post-surgical therapy .", "sentence_id": 6}
+{"abstract_id": "25151027", "label": "results", "text": "At @-year follow-up patients treated with en-block resection ( Groups @A and @A ) showed the lowest pain scores and the highest quality of life in comparison with the other two groups ( Group @B and @B ) .", "sentence_id": 7}
+{"abstract_id": "25151027", "label": "conclusions", "text": "GnRHa administration is followed by a temporary improvement of pain in patients with incomplete surgical treatment .", "sentence_id": 8}
+{"abstract_id": "25151027", "label": "conclusions", "text": "It seems that it has no role on post-surgical pain when the surgeon is able to completely excise DIE implants .", "sentence_id": 9}
+{"abstract_id": "25012446", "label": "background", "text": "Diminished quality of life ( QOL ) is associated with major depressive disorder ( MDD ) .", "sentence_id": 0}
+{"abstract_id": "25012446", "label": "methods", "text": "QOL was assessed in a post-hoc analysis of a double-blind , placebo-controlled trial .", "sentence_id": 1}
+{"abstract_id": "25012446", "label": "methods", "text": "Employed adult outpatients with MDD were randomly assigned to @ weeks of treatment with desvenlafaxine @mg/d or placebo .", "sentence_id": 2}
+{"abstract_id": "25012446", "label": "methods", "text": "Changes from baseline in the Short Form of the Quality of Life Enjoyment and Satisfaction Questionnaire ( Q-LES-Q ) item scores at week @ were analyzed using analysis of covariance with treatment , region , and baseline in the model .", "sentence_id": 3}
+{"abstract_id": "25012446", "label": "methods", "text": "Correlations between change from baseline in the @-item Hamilton Rating Scale for Depression ( HAM-D@ ) total score and Q-LES-Q scores were computed .", "sentence_id": 4}
+{"abstract_id": "25012446", "label": "results", "text": "The intent-to-treat population included @ patients .", "sentence_id": 5}
+{"abstract_id": "25012446", "label": "results", "text": "There were statistically significant improvements from baseline for desvenlafaxine vs placebo in @ of @ Q-LES-Q item scores ( P values @ ) .", "sentence_id": 6}
+{"abstract_id": "25012446", "label": "results", "text": "The percentage of patients with severe QOL impairment ( @ SD below community norm ) at week @ was significantly lower for desvenlafaxine ( @ % ) vs placebo ( @ % ; P = @ ; baseline : @ % and @ % , respectively ) .", "sentence_id": 7}
+{"abstract_id": "25012446", "label": "results", "text": "Change in Q-LES-Q total score was highly correlated with change in HAM-D@ score at week @ , LOCF ( P < @ ) , and improvement in HAM-D@ total score at week @ predicted change in Q-LES-Q total score at week @ for the desvenlafaxine group ( F = @ ; P < @ ) but not placebo .", "sentence_id": 8}
+{"abstract_id": "25012446", "label": "conclusions", "text": "This analysis excluded patients who were unemployed , had severe comorbidities , and those taking multiple , concomitant medications .", "sentence_id": 9}
+{"abstract_id": "25012446", "label": "conclusions", "text": "Improvement in QOL and depressive symptoms was significantly greater for employed depressed patients treated with desvenlafaxine vs placebo .", "sentence_id": 10}
+{"abstract_id": "25038064", "label": "background", "text": "Although physical exercise improves motor aspects of Parkinson 's disease ( PD ) , it is not clear whether it may also have a neuroprotective effect .", "sentence_id": 0}
+{"abstract_id": "25038064", "label": "background", "text": "Objective .", "sentence_id": 1}
+{"abstract_id": "25038064", "label": "background", "text": "In this @-year follow-up study , we determined whether intensive exercise in the early stages of the disease slows down PD progression .", "sentence_id": 2}
+{"abstract_id": "25038064", "label": "methods", "text": "Forty newly diagnosed patients with PD were treated with rasagiline and randomly assigned to @ groups : MIRT Group ( two @-day multidisciplinary intensive rehabilitation treatments -LSB- MIRT -RSB- , at @-year interval ) and Control Group ( only drug ) .", "sentence_id": 3}
+{"abstract_id": "25038064", "label": "methods", "text": "In both groups , Unified Parkinson 's Disease Rating Scale Section II ( UPDRS II ) , UPDRS III , @-minute walking test ( @MWT ) , Timed Up-and-Go test ( TUG ) ; PD Disability Scale ( PDDS ) , and l-dopa equivalents were assessed at baseline ( T@ ) , @ months ( T@ ) , @ year ( T@ ) , @ months ( T@ ) , and @ years ( T@ ) later .", "sentence_id": 4}
+{"abstract_id": "25038064", "label": "results", "text": "Over @ years , UPDRS II , UPDRS III , TUG , and PDDS differentially progressed in the @ groups : In the MIRT Group , all scores at T@ were better than at T@ ( all Ps < @ ) .", "sentence_id": 5}
+{"abstract_id": "25038064", "label": "results", "text": "No changes were noted in the Control Group .", "sentence_id": 6}
+{"abstract_id": "25038064", "label": "results", "text": "l-dopa equivalent dosages increased significantly only in the Control Group ( P = @ ) , with a decrease in the percentages of patients in monotherapy ( T@ @ % ; T@ , T@ , and T@ @ % ) .", "sentence_id": 7}
+{"abstract_id": "25038064", "label": "results", "text": "In the MIRT Group , the percentages of such patients remained higher ( T@ and T@ @ % ; T@ @ % ; T@ @ % ) .", "sentence_id": 8}
+{"abstract_id": "25038064", "label": "conclusions", "text": "These results suggest that MIRT might slow down the progression of motor decay , it might delay the need for increasing drug treatment , and thus , it might have a neuroprotective effect .", "sentence_id": 9}
+{"abstract_id": "24292746", "label": "objective", "text": "The aim of the present study was to investigate whether the following four markers : vitamin B@ , selenium , vitamin D , and parvalbumin may be used as compliance markers for fish intake .", "sentence_id": 0}
+{"abstract_id": "24292746", "label": "methods", "text": "Blood samples from a randomized cross-over herring intervention study ( n = @ ) were analysed by HPLC and immunochemistry .", "sentence_id": 1}
+{"abstract_id": "24292746", "label": "methods", "text": "The criteria were that plasma or serum concentrations of candidate compliance markers after the herring diet should increase significantly compared to starting concentrations .", "sentence_id": 2}
+{"abstract_id": "24292746", "label": "methods", "text": "In addition , the reference meat diet should not yield an increase in plasma concentration of the candidate marker .", "sentence_id": 3}
+{"abstract_id": "24292746", "label": "results", "text": "Vitamin B@ and selenium met the set criteria for indicating a correlation between the marker and fish intake with significant increases in serum concentrations at @ % ( p = @ ) and @ % ( p = @ ) , respectively , after a @-week herring intervention ( @ meals a week ) .", "sentence_id": 4}
+{"abstract_id": "24292746", "label": "results", "text": "Parvalbumin and @-hydroxy vitamin D@ levels did not increase significantly after the herring interventions .", "sentence_id": 5}
+{"abstract_id": "24292746", "label": "conclusions", "text": "Vitamin B@ may be suitable as a compliance marker for fish intake .", "sentence_id": 6}
+{"abstract_id": "24292746", "label": "conclusions", "text": "Although selenium also met the criteria , the change in selenium serum concentrations was small compared to the change in vitamin B@ levels .", "sentence_id": 7}
+{"abstract_id": "25073573", "label": "objective", "text": "To evaluate peripheral nerve safety and clinical efficacy of tanezumab in patients with painful osteoarthritis .", "sentence_id": 0}
+{"abstract_id": "25073573", "label": "methods", "text": "Patients received intravenous tanezumab @mg , tanezumab @mg , or placebo every @ weeks for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25073573", "label": "methods", "text": "Neurological safety was evaluated via a composite score ( nerve conduction attributes and heart rate variability with deep breathing ; @NC + HRdb ) , intraepidermal nerve fiber ( IENF ) density , and clinical assessments .", "sentence_id": 2}
+{"abstract_id": "25073573", "label": "methods", "text": "Efficacy and general safety were also evaluated .", "sentence_id": 3}
+{"abstract_id": "25073573", "label": "results", "text": "The study was stopped prematurely by an FDA partial clinical hold ( joint safety issues in other studies ) .", "sentence_id": 4}
+{"abstract_id": "25073573", "label": "results", "text": "Differences in change from baseline to Week @ in @NC + HRdb were not significant .", "sentence_id": 5}
+{"abstract_id": "25073573", "label": "results", "text": "Tanezumab @mg vs placebo exceeded the prespecified clinically important difference using last observation carried forward imputation , but not with observed data or when patients with evidence of neuropathy at baseline were excluded .", "sentence_id": 6}
+{"abstract_id": "25073573", "label": "results", "text": "No significant differences were found in individual nerve conduction measures .", "sentence_id": 7}
+{"abstract_id": "25073573", "label": "results", "text": "No treatment exceeded the prespecified clinically important decrease in IENF .", "sentence_id": 8}
+{"abstract_id": "25073573", "label": "results", "text": "Tanezumab resulted in significant improvement in pain , physical function , and Patient 's Global Assessment .", "sentence_id": 9}
+{"abstract_id": "25073573", "label": "results", "text": "Safety was similar to previous tanezumab clinical trials .", "sentence_id": 10}
+{"abstract_id": "25073573", "label": "conclusions", "text": "Tanezumab has a modulating effect on pain , does not appear to increase neurological safety signals , and offers a potentially promising , novel approach in treatment of pain .", "sentence_id": 11}
+{"abstract_id": "25338241", "label": "objective", "text": "To evaluate the safety of the performance of the traditional and protected collection techniques of tracheal aspirate and to identify qualitative and quantitative agreement of the results of microbiological cultures between the techniques .", "sentence_id": 0}
+{"abstract_id": "25338241", "label": "methods", "text": "Clinical , prospective , comparative , single-blind research .", "sentence_id": 1}
+{"abstract_id": "25338241", "label": "methods", "text": "The sample was composed of @ patients of > @ years of age , undergoing invasive mechanical ventilation for a period of @ hours and with suspected Ventilator Associated Pneumonia .", "sentence_id": 2}
+{"abstract_id": "25338241", "label": "methods", "text": "The two techniques were implemented in the same patient , one immediately after the other , with an order of random execution , according to randomization by specialized software .", "sentence_id": 3}
+{"abstract_id": "25338241", "label": "results", "text": "No significant events occurred oxygen desaturation , hemodynamic instability or tracheobronchial hemorrhage ( p < @ ) and , although there were differences in some strains , there was qualitative and quantitative agreement between the techniques ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25338241", "label": "conclusions", "text": "Utilization of the protected technique provided no advantage over the traditional and execution of both techniques was safe for the patient .", "sentence_id": 5}
+{"abstract_id": "25992536", "label": "background", "text": "The spot urine protein/creatinine ratio ( UPCR ) is proposed to be a substitute for @-hour urinary protein ( @h-UP ) .", "sentence_id": 0}
+{"abstract_id": "25992536", "label": "background", "text": "This study is aimed to determine whether the predictive accuracy of @h-UP using UPCR can be improved by simply multiplying estimated daily urine creatinine excretion ( eUCr ) and UPCR together .", "sentence_id": 1}
+{"abstract_id": "25992536", "label": "methods", "text": "This study enrolled @ participants to investigate the correlation between spot UPCR and @h-UP .", "sentence_id": 2}
+{"abstract_id": "25992536", "label": "methods", "text": "Three sets of spot urine samples were randomly collected throughout the day and night , along with the first morning void .", "sentence_id": 3}
+{"abstract_id": "25992536", "label": "methods", "text": "UPCR was weighted by eUCr to investigate the improvement of accuracy in using spot urine samples to predict @h-UP .", "sentence_id": 4}
+{"abstract_id": "25992536", "label": "results", "text": "There were strong correlation and concordance between UPCR and @h-UP irrespective of the time of spot urine sampling , and the correlation , concordance and agreement were improved after multiplying the UPCR value by the eUCr .", "sentence_id": 5}
+{"abstract_id": "25992536", "label": "results", "text": "Greater improvement was found in the subgroups with measured daily urine creatinine excretion @ g/d and @ g/d .", "sentence_id": 6}
+{"abstract_id": "25992536", "label": "conclusions", "text": "This investigation demonstrated that multiplying UPCR by eUCr can improve the accuracy of only using UPCR to predict @h-UP .", "sentence_id": 7}
+{"abstract_id": "24832000", "label": "background", "text": "Malignant pleural effusion is associated with short life expectancy and significant morbidity .", "sentence_id": 0}
+{"abstract_id": "24832000", "label": "background", "text": "A randomized controlled trial comparing indwelling pleural catheters ( IPCs ) with talc pleurodesis found that IPCs reduced in-hospital time and the need for additional procedures but were associated with excess adverse events .", "sentence_id": 1}
+{"abstract_id": "24832000", "label": "methods", "text": "Using data from the clinical trial , we compared costs associated with use of IPCs and with talc pleurodesis .", "sentence_id": 2}
+{"abstract_id": "24832000", "label": "methods", "text": "Resource use and adverse events were captured through case report forms over the @-year trial follow-up .", "sentence_id": 3}
+{"abstract_id": "24832000", "label": "methods", "text": "Costs for outpatient and inpatient visits , diagnostic imaging , nursing , and doctor time were obtained from the UK National Health Service reference costs and University of Kent 's Unit Costs of Health and Social Care @ and inflated to @ using the UK Consumer Price Index .", "sentence_id": 4}
+{"abstract_id": "24832000", "label": "methods", "text": "Procedure supply costs were obtained from the manufacturer .", "sentence_id": 5}
+{"abstract_id": "24832000", "label": "methods", "text": "Difference in mean costs was compared using nonparametric bootstrapping .", "sentence_id": 6}
+{"abstract_id": "24832000", "label": "methods", "text": "All costs were converted to US dollars using the Organisation for Economic Co-operation and Development Purchasing Power Parity Index .", "sentence_id": 7}
+{"abstract_id": "24832000", "label": "results", "text": "Overall mean cost ( SD ) for managing patients with IPCs and talc pleurodesis was $ @,@ ( $ @,@ ) and $ @,@ ( $ @,@ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "24832000", "label": "results", "text": "The incremental mean cost difference was $ @ , with @ % CI of - $ @,@ to $ @,@ .", "sentence_id": 9}
+{"abstract_id": "24832000", "label": "results", "text": "The mean cost related to ongoing drainage in the IPC group was $ @,@ ( $ @ ) vs $ @ ( $ @ ) in the talc pleurodesis group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24832000", "label": "results", "text": "This included the cost of drainage bottles , dressing changes in the first month , and catheter removal .", "sentence_id": 11}
+{"abstract_id": "24832000", "label": "results", "text": "There was no significant difference in cost of the initial intervention or adverse events between the groups .", "sentence_id": 12}
+{"abstract_id": "24832000", "label": "results", "text": "For patients with survival < @ weeks , IPC is significantly less costly than talc pleurodesis , with mean cost difference of - $ @,@ ( @ % CI , - $ @,@ to - $ @ ) .", "sentence_id": 13}
+{"abstract_id": "24832000", "label": "conclusions", "text": "There is no significant difference in the mean cost of managing patients with IPCs compared with talc pleurodesis .", "sentence_id": 14}
+{"abstract_id": "24832000", "label": "conclusions", "text": "For patients with limited survival , IPC appears less costly .", "sentence_id": 15}
+{"abstract_id": "24815795", "label": "background", "text": "In pulmonary arterial hypertension ( PAH ) , adding oral sildenafil to intravenous epoprostenol improved @-minute walk distance ( @MWD ) and hemodynamics and delayed time to clinical worsening in a @-week randomized , placebo-controlled trial ( Pulmonary Arterial Hypertension Combination Study of Epoprostenol and Sildenafil -LSB- PACES-@ -RSB- ) .", "sentence_id": 0}
+{"abstract_id": "24815795", "label": "methods", "text": "Patients completing PACES-@ could receive sildenafil ( titrated to @ mg , three times daily , as tolerated ) in an open-label extension study ( PACES-@ ) for @ years ; additional therapy was added according to investigator judgment .", "sentence_id": 1}
+{"abstract_id": "24815795", "label": "methods", "text": "Survival and changes from PACES-@ baseline in World Health Organization Functional Class and @MWD were captured .", "sentence_id": 2}
+{"abstract_id": "24815795", "label": "results", "text": "In an open-label setting , @MWD , an effort-dependent outcome measure , was known to have improved or to have been maintained in @ % , @ % , and @ % of patients at @ , @ , and @ years , respectively ; functional class was known to have improved or to have been maintained in @ % , @ % , and @ % .", "sentence_id": 3}
+{"abstract_id": "24815795", "label": "results", "text": "At @ years , @ % of patients were known to be alive , @ % were known to have died , and @ % were lost to follow-up .", "sentence_id": 4}
+{"abstract_id": "24815795", "label": "results", "text": "Patients with PACES-@ baseline @MWD < @ meters without @MWD improvement during the first @ weeks of sildenafil treatment subsequently had poorer survival .", "sentence_id": 5}
+{"abstract_id": "24815795", "label": "conclusions", "text": "Although reliable assessments of safety and efficacy require a long-term randomized trial , the addition of sildenafil to background intravenous epoprostenol therapy appeared generally to be well tolerated in PAH patients .", "sentence_id": 6}
+{"abstract_id": "24474302", "label": "objective", "text": "Erlotinib , N - ( @-ethynylphenyl ) -@,@ - bis ( @-methoxyethoxy ) quinazolin-@-amine is approved for the treatment for non-small cell lung cancer and pancreatic cancer .", "sentence_id": 0}
+{"abstract_id": "24474302", "label": "objective", "text": "Because erlotinib is metabolized predominately by CYP@A@ , co-administration of compounds that increase CYP@A@ activity may alter the efficacy and safety of erlotinib therapy .", "sentence_id": 1}
+{"abstract_id": "24474302", "label": "objective", "text": "Two phase I studies were conducted in healthy male subjects to evaluate the effect of pre - or co-administered rifampicin , a CYP@A@ inducer , on the pharmacokinetics of erlotinib .", "sentence_id": 2}
+{"abstract_id": "24474302", "label": "methods", "text": "Study @ included Groups A ( erlotinib @ mg days @ and @ , rifampicin @ mg days @-@ ) and B ( erlotinib @ mg days @ and @ ) in a parallel group study design .", "sentence_id": 3}
+{"abstract_id": "24474302", "label": "methods", "text": "Study @ subjects received erlotinib @ mg day @ , erlotinib @ mg day @ , and rifampicin @ mg days @-@ .", "sentence_id": 4}
+{"abstract_id": "24474302", "label": "methods", "text": "The primary endpoint in each study was the ratio of exposure ( AUC@ - and C max ) between days @ and @ .", "sentence_id": 5}
+{"abstract_id": "24474302", "label": "methods", "text": "Urinary cortisol metabolic induction ratios were determined in Study @ for Group A subjects only .", "sentence_id": 6}
+{"abstract_id": "24474302", "label": "results", "text": "In Study @ , the geometric mean ratios of AUC@ - and C max were @ and @ % , respectively , and the mean cortisol metabolic index increased from @ to @ , suggesting cytochrome P@ ( CYP ) enzyme induction .", "sentence_id": 7}
+{"abstract_id": "24474302", "label": "results", "text": "In Study @ , the geometric mean ratios for AUC@ - and C max were @ and @ % ( when dose adjusted from @ to @ mg erlotinib ) , respectively , a greater relative decrease than observed in Study @ .", "sentence_id": 8}
+{"abstract_id": "24474302", "label": "conclusions", "text": "Erlotinib exposure ( AUC@ - and C max ) was reduced after pre - or concomitant dosing with rifampicin .", "sentence_id": 9}
+{"abstract_id": "24474302", "label": "conclusions", "text": "Doses of @ mg erlotinib may be necessary to compensate for concomitant medications with strong CYP@A@ enzyme induction effect .", "sentence_id": 10}
+{"abstract_id": "25878306", "label": "background", "text": "Radiostereometric analysis provides highly precise measurements of component micromotion relative to the bone that is otherwise undetectable by routine radiographs .", "sentence_id": 0}
+{"abstract_id": "25878306", "label": "background", "text": "This study compared , at a minimum of five years following surgery , the micromotion of tantalum and titanium acetabular cups and femoral head penetration in highly cross-linked polyethylene liners and conventional ( ultra-high molecular weight polyethylene ) liners in active patients who had undergone total hip replacement .", "sentence_id": 1}
+{"abstract_id": "25878306", "label": "methods", "text": "This institutional review board-approved prospective , randomized , blinded study involved forty-six patients .", "sentence_id": 2}
+{"abstract_id": "25878306", "label": "methods", "text": "Patients were randomized into one of four cohorts according to both acetabular cup and polyethylene liner .", "sentence_id": 3}
+{"abstract_id": "25878306", "label": "methods", "text": "Patients received either a cementless cup with a titanium mesh surface or a tantalum trabecular surface and either a highly cross-linked polyethylene liner or an ultra-high molecular weight polyethylene liner .", "sentence_id": 4}
+{"abstract_id": "25878306", "label": "methods", "text": "Radiostereometric analysis examinations and Short Form-@ Physical Component Summary , Western Ontario and McMaster Universities Osteoarthritis Index ( WOMAC ) , University of California Los Angeles ( UCLA ) activity , and Harris hip scores were obtained preoperatively , postoperatively , at six months , and annually thereafter .", "sentence_id": 5}
+{"abstract_id": "25878306", "label": "results", "text": "All patients had significant improvement ( p < @ ) in Short Form-@ Physical Component Summary , WOMAC , UCLA activity , and Harris hip scores postoperatively .", "sentence_id": 6}
+{"abstract_id": "25878306", "label": "results", "text": "On radiostereometric analysis examination , highly cross-linked polyethylene liners showed significantly less median femoral head penetration at five years ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25878306", "label": "results", "text": "Steady-state wear rates from one year to five years were @ mm per year for ultra-high molecular weight polyethylene liners and @ mm per year for highly cross-linked polyethylene liners .", "sentence_id": 8}
+{"abstract_id": "25878306", "label": "results", "text": "At the five-year follow-up , the median migration ( and standard error ) was @ @ mm proximally for titanium cups and @ @ mm for tantalum cups .", "sentence_id": 9}
+{"abstract_id": "25878306", "label": "conclusions", "text": "In this young population who had undergone total hip replacement , radiostereometric analysis showed significantly less femoral head penetration in the highly cross-linked polyethylene liners compared with that in the conventional ultra-high molecular weight polyethylene liners .", "sentence_id": 10}
+{"abstract_id": "25878306", "label": "conclusions", "text": "Penetration rates were one order of magnitude less in highly cross-linked polyethylene liners compared with ultra-high molecular weight polyethylene liners .", "sentence_id": 11}
+{"abstract_id": "25878306", "label": "conclusions", "text": "There was no significant difference in proximal migration between the tantalum and titanium acetabular cups through the five-year follow-up ( p > @ ) .", "sentence_id": 12}
+{"abstract_id": "26026737", "label": "background", "text": "Inactivity and sedentary behavior are related to poorer health outcomes in breast cancer survivors .", "sentence_id": 0}
+{"abstract_id": "26026737", "label": "background", "text": "However , few studies examining these behaviors in survivors have used objective measures , considered activities other than moderate-to-vigorous intensity activity ( MVPA ) and/or sedentary behavior ( i.e. low intensity activities ) or compared survivors to healthy controls .", "sentence_id": 1}
+{"abstract_id": "26026737", "label": "background", "text": "The purpose of the present study is to compare accelerometer-measured activity of various intensities ( total , light , lifestyle , MVPA ) and sedentary behavior between breast cancer survivors and non-cancer controls .", "sentence_id": 2}
+{"abstract_id": "26026737", "label": "methods", "text": "An imputation-based approach of independent sample t-tests adjusting for multiple comparisons was used to compare estimates of participation in each activity and sedentary behavior between survivors -LSB- n = @ ; M ( SD ) age = @ ( @ ) -RSB- and block-matched non-cancer controls -LSB- n = @ ; M ( SD ) age = @ ( @ ) -RSB- .", "sentence_id": 3}
+{"abstract_id": "26026737", "label": "methods", "text": "Potential moderating effects of body mass index ( BMI ) , age , and education were also examined .", "sentence_id": 4}
+{"abstract_id": "26026737", "label": "results", "text": "Breast cancer survivors registered less daily total ( @ v. @ ) light ( @ v. @ ) and lifestyle ( @ v. @ ) activity minutes and more MVPA ( @ v. @ ) and sedentary behavior ( @ v. @ ) minutes than controls ( p < @ for all ) .", "sentence_id": 5}
+{"abstract_id": "26026737", "label": "results", "text": "These relationships were largely consistent across BMI , age and education .", "sentence_id": 6}
+{"abstract_id": "26026737", "label": "results", "text": "On average , survivors spent an estimated @ % of their waking time sedentary and @ % in light/lifestyle activity and @ % in MVPA .", "sentence_id": 7}
+{"abstract_id": "26026737", "label": "conclusions", "text": "Breast cancer survivors are more sedentary and participate in less low intensity activity than controls .", "sentence_id": 8}
+{"abstract_id": "26026737", "label": "conclusions", "text": "Although survivors registered more MVPA , these levels were insufficient .", "sentence_id": 9}
+{"abstract_id": "26026737", "label": "conclusions", "text": "Future research should explore these differences and potential benefits of targeting low intensity activities and reducing sedentary time in this population .", "sentence_id": 10}
+{"abstract_id": "24804638", "label": "background", "text": "Scarring represents a significant biomedical burden in clinical medicine .", "sentence_id": 0}
+{"abstract_id": "24804638", "label": "background", "text": "Mechanomodulation has been linked to scarring through inflammation , but until now a systematic approach to attenuate mechanical force and reduce scarring has not been possible .", "sentence_id": 1}
+{"abstract_id": "24804638", "label": "methods", "text": "The authors conducted a @-month , prospective , open-label , randomized , multicenter clinical trial to evaluate abdominoplasty scar appearance following postoperative treatment with the embrace Advanced Scar Therapy device to reduce mechanical forces on healing surgical incisions .", "sentence_id": 2}
+{"abstract_id": "24804638", "label": "methods", "text": "Incisions from @ healthy adult subjects were randomized to receive embrace treatment on one half of an abdominoplasty incision and control treatment ( surgeon 's optimal care methods ) on the other half .", "sentence_id": 3}
+{"abstract_id": "24804638", "label": "methods", "text": "The primary endpoint for this study was the difference between assessments of scar appearance for the treated and control sides using the visual analogue scale scar score .", "sentence_id": 4}
+{"abstract_id": "24804638", "label": "results", "text": "Final @-month study photographs were obtained from @ subjects who completed at least @ weeks of dressing application .", "sentence_id": 5}
+{"abstract_id": "24804638", "label": "results", "text": "The mean visual analogue scale score for embrace-treated scars ( @ ) was significantly improved compared with control-treated scars ( @ ) at @ months ( difference , @ ; @ percent confidence interval , @ to @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24804638", "label": "results", "text": "Both subjects and investigators found that embrace-treated scars demonstrated significant improvements in overall appearance at @ months using the Patient and Observer Scar Assessment Scale evaluation ( p = @ and p < @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24804638", "label": "results", "text": "No serious adverse events were reported .", "sentence_id": 8}
+{"abstract_id": "24804638", "label": "conclusions", "text": "These results demonstrate that the embrace device significantly reduces scarring following abdominoplasty surgery .", "sentence_id": 9}
+{"abstract_id": "24804638", "label": "conclusions", "text": "To the authors ' knowledge , this represents the first level I evidence for postoperative scar reduction .", "sentence_id": 10}
+{"abstract_id": "24804638", "label": "methods", "text": "Therapeutic , II .", "sentence_id": 11}
+{"abstract_id": "24297318", "label": "background", "text": "Peritoneal dialysis ( PD ) requires patients to take an active role in their adherence to fluid restrictions .", "sentence_id": 0}
+{"abstract_id": "24297318", "label": "background", "text": "Although fluid non-adherence had been identified among this patient group , no specific interventions have been researched or published with in the PD population .", "sentence_id": 1}
+{"abstract_id": "24297318", "label": "background", "text": "The current study sought to investigate whether an applied cognitive behavioural therapy ( CBT-based intervention ) used among haemodialysis patients would improve fluid adherence among PD patients ; utilizing clinical indicators used in practice .", "sentence_id": 2}
+{"abstract_id": "24297318", "label": "methods", "text": "Fifteen PD patients identified as fluid non-adherent were randomly assigned to an intervention group ( IG ) or a deferred-entry control group ( CG ) .", "sentence_id": 3}
+{"abstract_id": "24297318", "label": "methods", "text": "The study ran for a total of @ weeks , with five data collection points ; at baseline , post-intervention and at three follow-up points ; providing a RCT phase and a combined longitudinal analysis phase .", "sentence_id": 4}
+{"abstract_id": "24297318", "label": "methods", "text": "The content of the group intervention encompassed educational , cognitive and behavioural components , aimed to assist patients ' self-management of fluid .", "sentence_id": 5}
+{"abstract_id": "24297318", "label": "results", "text": "No significant differences in weight ( kg ) reduction were found in either phase and undesirable changes in blood pressure ( BP ) were observed .", "sentence_id": 6}
+{"abstract_id": "24297318", "label": "results", "text": "However , in the longitudinal phase , a statistically significant difference in oedematous status was observed at @-week follow-up ; which may be indicative of fluid adherence .", "sentence_id": 7}
+{"abstract_id": "24297318", "label": "results", "text": "Positive and significant differences were observed in the desired direction for measures of psychological well-being , quality of life and health beliefs ; areas correlated with enhanced fluid adherence in other research .", "sentence_id": 8}
+{"abstract_id": "24297318", "label": "conclusions", "text": "This study reveals encouraging and significant changes in predictors of fluid adherence .", "sentence_id": 9}
+{"abstract_id": "24297318", "label": "conclusions", "text": "Although there were no significant changes in weight as a crude clinical measure of fluid intake , significant reductions in oedematous status were observed as a consequence of this CBT-based group intervention .", "sentence_id": 10}
+{"abstract_id": "25127659", "label": "background", "text": "This study compared palonosetron and ondansetron as rescue medications for postoperative nausea and vomiting ( PONV ) in patients who received prophylactic ondansetron .", "sentence_id": 0}
+{"abstract_id": "25127659", "label": "background", "text": "Although guidelines recommend use of an agent from a different class when prophylaxis has failed , palonosetron has unique properties relative to other serotonin @-HT@ receptor antagonists .", "sentence_id": 1}
+{"abstract_id": "25127659", "label": "background", "text": "Prior trials assessing its use for rescue have had conflicting results .", "sentence_id": 2}
+{"abstract_id": "25127659", "label": "background", "text": "Although palonosetron has compared favorably with ondansetron for PONV prevention , the drugs have not been compared in the rescue setting of failure of @-HT@ receptor antagonist prophylaxis .", "sentence_id": 3}
+{"abstract_id": "25127659", "label": "methods", "text": "This was a randomized , open-label , multicenter trial comparing the efficacy and safety of intravenous palonosetron @ mg and intravenous ondansetron @mg in patients experiencing PONV following laparoscopic abdominal or gynecological surgery despite prophylactic ondansetron .", "sentence_id": 4}
+{"abstract_id": "25127659", "label": "results", "text": "Of @ patients screened , @ were enrolled and @ were treated for PONV : @ and @ in the palonosetron and ondansetron arms , respectively .", "sentence_id": 5}
+{"abstract_id": "25127659", "label": "results", "text": "Complete control during @hours after study drug administration was achieved in @ % of palonosetron recipients and @ % of ondansetron recipients ( @ % confidence interval -LSB- CI -RSB- , -@ , @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25127659", "label": "results", "text": "Corresponding incidences of vomiting were @ % for palonosetron and @ % for ondansetron ( @ % CI , -@ , @ ; p = @ ) , and @ % and @ % required additional rescue treatment , respectively ( @ % CI , -@ , @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25127659", "label": "results", "text": "Other than a similar incidence of procedural pain in the @ groups , the most common treatment-emergent adverse events , which were generally mild , were headache ( @ % vs @ % ) , constipation ( @ % vs @ % ) , and dizziness ( @ % vs @ % ) , for the palonosetron and ondansetron groups , respectively .", "sentence_id": 8}
+{"abstract_id": "25127659", "label": "conclusions", "text": "Palonosetron and ondansetron did not show differences in the primary efficacy endpoint of CC during the @hours after study drug administration .", "sentence_id": 9}
+{"abstract_id": "25127659", "label": "conclusions", "text": "There was a trend toward less emesis in the @-@h time period favoring palonosetron .", "sentence_id": 10}
+{"abstract_id": "25127659", "label": "conclusions", "text": "While larger studies are needed to fully assess any clinical benefits of palonosetron to rescue patients who have failed ondansetron prophylaxis for PONV , the benefit , if any , would be limited based on this study .", "sentence_id": 11}
+{"abstract_id": "25573393", "label": "background", "text": "Current methods of the transtibial pull-out meniscal root repair significantly displace under cyclic loading in porcine models but have not been evaluated in human models .", "sentence_id": 0}
+{"abstract_id": "25573393", "label": "background", "text": "One potential explanation for the displacement is that a single transtibial tunnel may not fully restore the attachment of the entire posterior medial meniscal root .", "sentence_id": 1}
+{"abstract_id": "25573393", "label": "objective", "text": "The purpose of this study was to biomechanically evaluate the transtibial pull-out technique in a human cadaveric model using either @ or @ transtibial bone tunnels .", "sentence_id": 2}
+{"abstract_id": "25573393", "label": "objective", "text": "The hypothesis was that a transtibial pull-out technique using @ transtibial bone tunnels would confer superior biomechanical properties in comparison to an iteration using @ transtibial bone tunnel .", "sentence_id": 3}
+{"abstract_id": "25573393", "label": "methods", "text": "Controlled laboratory study .", "sentence_id": 4}
+{"abstract_id": "25573393", "label": "methods", "text": "Ten matched pairs of male human cadaveric knees ( average age , @ years ) were randomly assigned ( @ each of the pair ) to @ groups consisting of a transtibial pull-out technique using either @ or @ transtibial bone tunnels .", "sentence_id": 5}
+{"abstract_id": "25573393", "label": "methods", "text": "The knees were cyclically loaded for @ cycles from @ to @ N at @ Hz , representing the loads experienced during a typical meniscal root repair postoperative rehabilitation program , and then pulled to failure at a rate of @ mm/s .", "sentence_id": 6}
+{"abstract_id": "25573393", "label": "results", "text": "Differences between @ - and @-tunnel repair groups were neither statistically nor clinically significant with respect to displacement or ultimate failure load .", "sentence_id": 7}
+{"abstract_id": "25573393", "label": "results", "text": "On average , the @ - and @-tunnel repair groups resulted in @ mm and @ mm of displacement , respectively , after @ testing cycles .", "sentence_id": 8}
+{"abstract_id": "25573393", "label": "results", "text": "At @ , @ , @ , and @ testing cycles , displacement was not significantly different between groups ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25573393", "label": "results", "text": "The @-tunnel repair technique resulted in a @ % higher ultimate failure load ( @ N vs. @ N ) ; however , this was not significant ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25573393", "label": "conclusions", "text": "Similar biomechanical properties were seen between transtibial pull-out repairs using either @ or @ transtibial bone tunnels in a human cadaveric model .", "sentence_id": 11}
+{"abstract_id": "25573393", "label": "conclusions", "text": "Both repair groups exceeded the @-mm threshold for nonanatomic displacement .", "sentence_id": 12}
+{"abstract_id": "25573393", "label": "conclusions", "text": "This study indicates that a newly proposed iteration of the transtibial pull-out repair technique using a second transtibial tunnel , which theoretically restores more of the posterior medial meniscal root , was almost identical to the current clinical standard involving a single transtibial tunnel .", "sentence_id": 13}
+{"abstract_id": "25573393", "label": "conclusions", "text": "As the importance of repairing meniscal root tears is increasingly recognized , further studies on new iterations of both techniques are warranted to minimize the risk of displacement caused by early motion in the initial postoperative rehabilitation period .", "sentence_id": 14}
+{"abstract_id": "25397817", "label": "background", "text": "Several evidence-based treatments are available to veterans diagnosed with posttraumatic stress disorder ( PTSD ) .", "sentence_id": 0}
+{"abstract_id": "25397817", "label": "background", "text": "However , not all veterans benefit from these treatments or prefer to engage in them .", "sentence_id": 1}
+{"abstract_id": "25397817", "label": "objective", "text": "The current study explored whether ( @ ) a mantram repetition program ( MRP ) increased mindful attention among veterans with PTSD , ( @ ) mindful attention mediated reduced PTSD symptom severity and enhanced psychological well-being , and ( @ ) improvement in mindful attention was due to the frequency of mantram repetition practice .", "sentence_id": 2}
+{"abstract_id": "25397817", "label": "methods", "text": "Data from a randomized controlled trial comparing MRP plus treatment as usual ( MRP+TAU ) or TAU were analyzed using hierarchical linear models .", "sentence_id": 3}
+{"abstract_id": "25397817", "label": "methods", "text": "A total of @ veterans with PTSD from military-related trauma were recruited from a Veterans Affairs outpatient PTSD clinic ( @ MRP+TAU ; @ TAU ) .", "sentence_id": 4}
+{"abstract_id": "25397817", "label": "methods", "text": "The Clinician Administered PTSD Scale ( CAPS ) , PTSD Checklist ( PCL ) , the Brief Symptom Inventory-@ depression subscale , Health Survey SF-@v@ , and Mindfulness Attention Awareness Scale ( MAAS ) were used .", "sentence_id": 5}
+{"abstract_id": "25397817", "label": "methods", "text": "Frequency of mantram repetition practice was measured using wrist-worn counters and daily logs .", "sentence_id": 6}
+{"abstract_id": "25397817", "label": "results", "text": "Intent-to-treat analyses indicated greater increases in mindful attention , as measured by the MAAS , for MRP+TAU as compared with TAU participants ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25397817", "label": "results", "text": "Mindful attention gains mediated previously reported treatment effects on reduced PTSD symptoms ( using both CAPS and PCL ) , reduced depression , and improved psychological well-being .", "sentence_id": 8}
+{"abstract_id": "25397817", "label": "results", "text": "Frequency of mantram repetition practice in turn mediated increased mindful attention .", "sentence_id": 9}
+{"abstract_id": "25397817", "label": "conclusions", "text": "The MRP intervention and specifically , mantram practice , improved mindful attention in veterans with PTSD , yielding improved overall psychological well-being .", "sentence_id": 10}
+{"abstract_id": "25397817", "label": "conclusions", "text": "MRP may be a beneficial adjunct to usual care in veterans with PTSD .", "sentence_id": 11}
+{"abstract_id": "24974051", "label": "background", "text": "ODM-@ is a novel androgen receptor ( AR ) inhibitor designed to block the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuclear translocation .", "sentence_id": 0}
+{"abstract_id": "24974051", "label": "background", "text": "This trial assessed ODM-@ 's safety , pharmacokinetics , and activity in men with metastatic castration-resistant prostate cancer .", "sentence_id": 1}
+{"abstract_id": "24974051", "label": "methods", "text": "The ARADES trial is an open-label phase @-@ trial undertaken in @ hospitals across Europe and USA with ongoing long-term follow-up .", "sentence_id": 2}
+{"abstract_id": "24974051", "label": "methods", "text": "Men with progressive metastatic castration-resistant prostate cancer , who had castrate concentrations of testosterone and an Eastern Cooperative Oncology Group score of @-@ were enrolled .", "sentence_id": 3}
+{"abstract_id": "24974051", "label": "methods", "text": "In the phase @ part of the trial , patients were given oral ODM-@ at a starting daily dose of @ mg , which was increased to @ mg , @ mg , @ mg , @ mg , and @ mg .", "sentence_id": 4}
+{"abstract_id": "24974051", "label": "methods", "text": "In phase @ , patients were randomly assigned centrally and stratified by previous chemotherapy and treatment with CPY@ inhibitors , to receive one of three daily doses of ODM-@ ( @ mg , @ mg , and @ mg ) .", "sentence_id": 5}
+{"abstract_id": "24974051", "label": "methods", "text": "The primary endpoint in phase @ was safety and tolerability , whereas in phase @ it was the proportion of patients with a PSA response ( @ % or greater decrease in serum PSA ) at week @ .", "sentence_id": 6}
+{"abstract_id": "24974051", "label": "methods", "text": "All analyses included patients who had received at least one dose of ODM-@ .", "sentence_id": 7}
+{"abstract_id": "24974051", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ , and NCT@ for the follow-up after @ weeks .", "sentence_id": 8}
+{"abstract_id": "24974051", "label": "results", "text": "We enrolled patients between April @ , @ , and March @ , @ .", "sentence_id": 9}
+{"abstract_id": "24974051", "label": "results", "text": "In phase @ , @ patients were enrolled to six sequential cohorts of three to six patients and received a daily dose of ODM-@ , @-@ mg .", "sentence_id": 10}
+{"abstract_id": "24974051", "label": "results", "text": "No dose-limiting toxic effects were reported and the maximum tolerated dose was not reached .", "sentence_id": 11}
+{"abstract_id": "24974051", "label": "results", "text": "In phase @ , three patients reported eight adverse events of grade @ ( fracture , muscle injury , laceration , paralytic ileus , pain , presyncope , urinary retention , and vomiting ) and one patient had a grade @ adverse event ( lymphoedema ) .", "sentence_id": 12}
+{"abstract_id": "24974051", "label": "results", "text": "None of the grade @-@ adverse events were deemed to be related to ODM-@ .", "sentence_id": 13}
+{"abstract_id": "24974051", "label": "results", "text": "Of the phase @ patients , the four who received @ mg , seven who received @ mg , and three who received @ mg entered the phase @ part of the trial .", "sentence_id": 14}
+{"abstract_id": "24974051", "label": "results", "text": "In addition to these patients , @ were randomly assigned to three groups : @ mg ( n = @ ) , @ mg ( n = @ ) , and @ mg ( n = @ ) .", "sentence_id": 15}
+{"abstract_id": "24974051", "label": "results", "text": "For these patients , the most common treatment-emergent adverse events were fatigue or asthenia ( @ -LSB- @ % -RSB- of @ patients ) , hot flush ( six -LSB- @ % -RSB- ) , and decreased appetite ( five -LSB- @ % -RSB- ) .", "sentence_id": 16}
+{"abstract_id": "24974051", "label": "results", "text": "One patient ( < @ % ) had a grade @ treatment-emergent adverse event ( fatigue ) ; no patients had a treatment-emergent grade @ adverse event .", "sentence_id": 17}
+{"abstract_id": "24974051", "label": "results", "text": "@ patients who received @ mg , @ who received @ mg , and @ who received @ mg were assessable for PSA response at @ weeks .", "sentence_id": 18}
+{"abstract_id": "24974051", "label": "results", "text": "@ ( @ % ) patients in the @ mg group , @ ( @ % ) in the @ mg group , and @ ( @ % ) in the @ mg group had a PSA response at @ weeks .", "sentence_id": 19}
+{"abstract_id": "24974051", "label": "conclusions", "text": "Our results suggest that ODM-@ monotherapy in men with progressive metastatic castration-resistant prostate cancer provides disease suppression and that ODM-@ has a favourable safety profile .", "sentence_id": 20}
+{"abstract_id": "24974051", "label": "conclusions", "text": "These findings support further investigation of clinical responses with ODM-@ in men with castration-resistant prostate cancer .", "sentence_id": 21}
+{"abstract_id": "24553356", "label": "background", "text": "The United Kingdom Employment Retention and Advancement ( U.K. ERA ) demonstration was the largest and most comprehensive social experiment ever conducted in the United Kingdom .", "sentence_id": 0}
+{"abstract_id": "24553356", "label": "background", "text": "It examined the extent to which a combination of postemployment advisory support and financial incentives could help lone parents on welfare to find sustained employment with prospects for advancement .", "sentence_id": 1}
+{"abstract_id": "24553356", "label": "background", "text": "ERA was experimentally tested across more than @ public employment service offices and , within each office , individuals were randomly assigned to either a program ( or treatment ) group ( eligible for ERA ) or a control group ( not eligible ) .", "sentence_id": 2}
+{"abstract_id": "24553356", "label": "methods", "text": "This article presents the results of a multilevel nonexperimental analysis that examines the variation in office-level impacts and attempts to understand what services provided in the offices tend to be associated with impacts .", "sentence_id": 3}
+{"abstract_id": "24553356", "label": "results", "text": "The analysis suggests that impacts were greater in offices that emphasized in-work advancement , support while working and financial bonuses for sustained employment , and also in those offices that assigned more caseworkers to ERA participants .", "sentence_id": 4}
+{"abstract_id": "24553356", "label": "results", "text": "Offices that encouraged further education had smaller employment impacts .", "sentence_id": 5}
+{"abstract_id": "24553356", "label": "conclusions", "text": "Plausible results are obtained identifying those particular implementation features that tended to be linked to stronger impacts of ERA .", "sentence_id": 6}
+{"abstract_id": "24553356", "label": "conclusions", "text": "The methodology employed also allows the identification of which services are associated with employment and welfare receipt of control families receiving benefits under the traditional New Deal for Lone Parent program .", "sentence_id": 7}
+{"abstract_id": "24816691", "label": "background", "text": "Minimally invasive surgeries of the soft palate have emerged as a less-invasive treatment for habitual snoring .", "sentence_id": 0}
+{"abstract_id": "24816691", "label": "background", "text": "To date , there is only limited information available comparing the effects of snoring sound between different minimally invasive surgeries in the treatment of habitual snoring .", "sentence_id": 1}
+{"abstract_id": "24816691", "label": "objective", "text": "To compare the efficacy of palatal implant and radiofrequency surgery , in the reduction of snoring through subjective evaluation of snoring and objective snoring sound analysis .", "sentence_id": 2}
+{"abstract_id": "24816691", "label": "methods", "text": "Thirty patients with habitual snoring due to palatal obstruction ( apnea-hypopnea index @ , body max index @ ) were prospectively enrolled and randomized to undergo a single session of palatal implant or temperature-controlled radiofrequency surgery of the soft palate under local anesthesia .", "sentence_id": 3}
+{"abstract_id": "24816691", "label": "methods", "text": "Snoring was primarily evaluated by the patient with a @ cm visual analogue scale ( VAS ) at baseline and at a @-month follow-up visit and the change in VAS was the primary outcome .", "sentence_id": 4}
+{"abstract_id": "24816691", "label": "methods", "text": "Moreover , life qualities , measured by snore outcomes survey , and full-night snoring sounds , analyzed by a sound analytic program ( Snore Map ) , were also investigated at the same time .", "sentence_id": 5}
+{"abstract_id": "24816691", "label": "results", "text": "Twenty-eight patients completed the study ; @ received palatal implant surgery and @ underwent radiofrequency surgery .", "sentence_id": 6}
+{"abstract_id": "24816691", "label": "results", "text": "The VAS and snore outcomes survey scores were significantly improved in both groups .", "sentence_id": 7}
+{"abstract_id": "24816691", "label": "results", "text": "However , the good response ( postoperative VAS @ or postoperative VAS @ plus snore outcomes survey score @ ) rate of the palatal implant group was significantly higher than that of the radiofrequency group ( @ % vs. @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24816691", "label": "results", "text": "The maximal loudness of low-frequency ( @-@ Hz ) snores was reduced significantly in the palatal implant group .", "sentence_id": 9}
+{"abstract_id": "24816691", "label": "results", "text": "In addition , the snoring index was significantly reduced in the radiofrequency group .", "sentence_id": 10}
+{"abstract_id": "24816691", "label": "conclusions", "text": "Both palatal implants and a single-stage radiofrequency surgery improve subjective snoring outcomes , but palatal implants have a greater effect on most measures of subjective and objective snoring .", "sentence_id": 11}
+{"abstract_id": "24816691", "label": "conclusions", "text": "Multi-stage radiofrequency surgery was not tested .", "sentence_id": 12}
+{"abstract_id": "24793701", "label": "objective", "text": "To investigate whether a maneuver for repeated cycles of collapse and reexpansion of the operative lung , termed `` intermittent reinflation '' ( IR ) , to counter hypoxemia during one-lung ventilation ( OLV ) , results in a time-dependent alteration of extravascular lung water .", "sentence_id": 0}
+{"abstract_id": "24793701", "label": "methods", "text": "Prospective , randomized clinical study .", "sentence_id": 1}
+{"abstract_id": "24793701", "label": "methods", "text": "Operating room and postsurgical intensive care unit of a university hospital .", "sentence_id": 2}
+{"abstract_id": "24793701", "label": "methods", "text": "@ ASA physical status @ and @ patients undergoing elective , video-assisted thoracic surgery for lung tumors .", "sentence_id": 3}
+{"abstract_id": "24793701", "label": "methods", "text": "Patients were randomly assigned to two groups .", "sentence_id": 4}
+{"abstract_id": "24793701", "label": "methods", "text": "Group C consisted of @ patients whose nondependent lung was kept collapsed during OLV , while Group IR included @ patients with IR that consisted of @ separate , @-second manual inflations and @-second openings within one minute at intervals of @ minutes during OLV .", "sentence_id": 5}
+{"abstract_id": "24793701", "label": "methods", "text": "Perioperative parameters included transcutaneous oxygen saturation ( SpO@ ) , hemodynamic data , extravascular lung water index ( EVLWI ) , pulmonary vascular permeability index ( PVPI ) as determined by the single-indicator transpulmonary thermodilution technique , and partial pressure of arterial oxygen/inspired oxygen fraction ( PaO@/FIO@ ) ratio .", "sentence_id": 6}
+{"abstract_id": "24793701", "label": "results", "text": "Group IR had significantly higher SpO@ at @ minutes after commencement of OLV ( @ % vs @ % , P = @ ) and average SpO@ throughout OLV ( @ % vs @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24793701", "label": "results", "text": "Hemodynamic data , EVLWI , PVPI , and PaO@/FIO@ ratio did not differ between the groups , and there were no differences between groups in postoperative morbidity or hospital stay .", "sentence_id": 8}
+{"abstract_id": "24793701", "label": "conclusions", "text": "Intermittent reinflation had a beneficial effect on oxygenation during OLV , without any significant effects on EVLW or postoperative outcomes .", "sentence_id": 9}
+{"abstract_id": "25284089", "label": "objective", "text": "To report and discuss the multi-domain impact of elosulfase alfa , with focus on tertiary and composite endpoints , in the @-week , randomized , double-blind , placebo-controlled phase @ trial in patients with Morquio A syndrome ( mucopolysaccharidosis IVA ) .", "sentence_id": 0}
+{"abstract_id": "25284089", "label": "methods", "text": "Patients with Morquio A syndrome aged @ years were randomized @:@:@ to elosulfase alfa @ mg/kg/week ( qw ; N = @ ) , elosulfase alfa @ mg/kg/every other week ( qow ; N = @ ) , or placebo ( N = @ ) for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25284089", "label": "methods", "text": "Primary and secondary efficacy measures were @-minute walk test ( @MWT ; primary ) , @-minute stair climb test ( @-MSCT ) and urinary keratan sulfate ( KS ) .", "sentence_id": 2}
+{"abstract_id": "25284089", "label": "methods", "text": "Safety was also evaluated .", "sentence_id": 3}
+{"abstract_id": "25284089", "label": "methods", "text": "Tertiary efficacy measures included respiratory function measures , activities of daily living ( MPS Health Assessment Questionnaire -LSB- MPS-HAQ -RSB- ) , anthropometric , echocardiographic and radiographic measures , hearing and corneal clouding assessment .", "sentence_id": 4}
+{"abstract_id": "25284089", "label": "methods", "text": "In order to fully characterize treatment impact in this heterogeneous disorder , the effect of elosulfase alfa on composite efficacy measures was evaluated as well .", "sentence_id": 5}
+{"abstract_id": "25284089", "label": "results", "text": "The study was not designed to have sufficient power for any of the tertiary outcomes .", "sentence_id": 6}
+{"abstract_id": "25284089", "label": "results", "text": "For most tertiary endpoints , subjects treated with the weekly dose of elosulfase alfa improved more than those receiving placebo .", "sentence_id": 7}
+{"abstract_id": "25284089", "label": "results", "text": "The largest treatment effects were seen in maximal voluntary ventilation ( MVV ) , MPS-HAQ , height , and growth rate .", "sentence_id": 8}
+{"abstract_id": "25284089", "label": "results", "text": "The qow group appeared similar to placebo .", "sentence_id": 9}
+{"abstract_id": "25284089", "label": "results", "text": "The analysis of a pre-specified composite endpoint ( combining changes from baseline in @MWT , @MSCT and MVV z-scores equally weighted ) showed a modest positive impact of elosulfase alfa qw versus placebo group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25284089", "label": "results", "text": "As a pre-specified supportive analysis , the O'Brien Rank Sum composite endpoint ( changes from baseline in @MWT , @MSC , and MVV ) , analysis also showed that the qw group performed better than the placebo group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25284089", "label": "results", "text": "In post-hoc analyses , combinations of other endpoints were also explored using the O'Brien Rank Sum test and showed statistically significant differences between elosulfase alfa qw and placebo favoring elosulfase alfa qw .", "sentence_id": 12}
+{"abstract_id": "25284089", "label": "results", "text": "Differences between elosulfase alfa qow and placebo were not statistically significant .", "sentence_id": 13}
+{"abstract_id": "25284089", "label": "results", "text": "Positive changes were observed in most tertiary variables , demonstrating the efficacy of weekly treatment with elosulfase alfa .", "sentence_id": 14}
+{"abstract_id": "25284089", "label": "conclusions", "text": "Treatment with weekly elosulfase alfa led to improvements across most efficacy measures , resulting in clinically meaningful benefits in a heterogeneous study population .", "sentence_id": 15}
+{"abstract_id": "24885600", "label": "background", "text": "Acute myocardial infarction ( AMI ) is the leading cause of mortality worldwide .", "sentence_id": 0}
+{"abstract_id": "24885600", "label": "background", "text": "Oxidative stress has been involved in the ischemia-reperfusion injury in AMI .", "sentence_id": 1}
+{"abstract_id": "24885600", "label": "background", "text": "It has been suggested that reperfusion accounts for up to @ % of the final size of a myocardial infarct , a part of the damage likely to be prevented.Therefore , we propose that antioxidant reinforcement through vitamins C and E supplementation should protect against the ischemia-reperfusion damage , thus decreasing infarct size.The PREVEC Trial ( Prevention of reperfusion damage associated with percutaneous coronary angioplasty following acute myocardial infarction ) seeks to evaluate whether antioxidant vitamins C and E reduce infarct size in patients subjected to percutaneous coronary angioplasty after AMI .", "sentence_id": 2}
+{"abstract_id": "24885600", "label": "methods", "text": "This is a randomized , @:@ , double-blind , placebo-controlled clinical trial.The study takes place at two centers in Chile : University of Chile Clinical Hospital and San Borja Arriarn Clinical Hospital.The subjects will be @ adults with acute myocardial infarction with indication for percutaneous coronary angioplasty.This intervention is being performed as a pilot study , involving high-dose vitamin C infusion plus oral administration of vitamin E ( Vitamin-treatment group ) or placebo ( Control group ) during the angioplasty procedure .", "sentence_id": 3}
+{"abstract_id": "24885600", "label": "methods", "text": "Afterward , the Vitamin-treatment group receives oral doses of vitamins C and E , and the Control group receives placebo for @ days after coronary angioplasty.Primary outcome is infarct size , assessed by cardiac magnetic resonance ( CMR ) , measured @ and @ days after coronary angioplasty.Secondary outcomes are ejection fraction , measured @ and @ days after coronary angioplasty with CMR , and biomarkers for oxidative stress , antioxidant status , heart damage , and inflammation , which will be measured at baseline , at the onset of reperfusion , @ to @ hours after revascularization , and at hospital discharge .", "sentence_id": 4}
+{"abstract_id": "24885600", "label": "conclusions", "text": "The ischemia-reperfusion event occurring during angioplasty is known to increase myocardial infarct size .", "sentence_id": 5}
+{"abstract_id": "24885600", "label": "conclusions", "text": "The cardioprotective benefits of high doses of vitamin C combined with vitamin E have not been fully explored .", "sentence_id": 6}
+{"abstract_id": "24885600", "label": "conclusions", "text": "The PREVEC Trial seeks to determine the suitability of the therapeutic use of vitamins C and E against the reperfusion damage produced during angioplasty.Patient recruitment opened in February @ .", "sentence_id": 7}
+{"abstract_id": "24885600", "label": "conclusions", "text": "The trial is scheduled to end in March @ .", "sentence_id": 8}
+{"abstract_id": "24907062", "label": "objective", "text": "To evaluate the safety and efficacy of dexamethasone intravitreal implant ( Ozurdex , DEX implant ) @ and @ mg in the treatment of patients with diabetic macular edema ( DME ) .", "sentence_id": 0}
+{"abstract_id": "24907062", "label": "methods", "text": "Two randomized , multicenter , masked , sham-controlled , phase III clinical trials with identical protocols were conducted .", "sentence_id": 1}
+{"abstract_id": "24907062", "label": "methods", "text": "Data were pooled for analysis .", "sentence_id": 2}
+{"abstract_id": "24907062", "label": "methods", "text": "Patients ( n = @ ) with DME , best-corrected visual acuity ( BCVA ) of @/@ to @/@ Snellen equivalent , and central retinal thickness ( CRT ) of @ m by optical coherence tomography .", "sentence_id": 3}
+{"abstract_id": "24907062", "label": "methods", "text": "Patients were randomized in a @:@:@ ratio to study treatment with DEX implant @ mg , DEX implant @ mg , or sham procedure and followed for @ years ( or @ months for patients treated at month @ ) at @ scheduled visits .", "sentence_id": 4}
+{"abstract_id": "24907062", "label": "methods", "text": "Patients who met retreatment eligibility criteria could be retreated no more often than every @ months .", "sentence_id": 5}
+{"abstract_id": "24907062", "label": "methods", "text": "The predefined primary efficacy endpoint for the United States Food and Drug Administration was achievement of @-letter improvement in BCVA from baseline at study end .", "sentence_id": 6}
+{"abstract_id": "24907062", "label": "methods", "text": "Safety measures included adverse events and intraocular pressure ( IOP ) .", "sentence_id": 7}
+{"abstract_id": "24907062", "label": "results", "text": "Mean number of treatments received over @ years was @ , @ , and @ with DEX implant @ mg , DEX implant @ mg , and sham , respectively .", "sentence_id": 8}
+{"abstract_id": "24907062", "label": "results", "text": "The percentage of patients with @-letter improvement in BCVA from baseline at study end was greater with DEX implant @ mg ( @ % ) and DEX implant @ mg ( @ % ) than sham ( @ % ; P @ ) .", "sentence_id": 9}
+{"abstract_id": "24907062", "label": "results", "text": "Mean average reduction in CRT from baseline was greater with DEX implant @ mg ( -@ m ) and DEX implant @ mg ( -@ m ) than sham ( -@ m ; P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24907062", "label": "results", "text": "Rates of cataract-related adverse events in phakic eyes were @ % , @ % , and @ % in the DEX implant @ mg , DEX implant @ mg , and sham groups , respectively .", "sentence_id": 11}
+{"abstract_id": "24907062", "label": "results", "text": "Increases in IOP were usually controlled with medication or no therapy ; only @ patients ( @ % ) in the DEX implant @ mg group and @ ( @ % ) in the DEX implant @ mg group required trabeculectomy .", "sentence_id": 12}
+{"abstract_id": "24907062", "label": "conclusions", "text": "The DEX implant @ mg and @ mg met the primary efficacy endpoint for improvement in BCVA .", "sentence_id": 13}
+{"abstract_id": "24907062", "label": "conclusions", "text": "The safety profile was acceptable and consistent with previous reports .", "sentence_id": 14}
+{"abstract_id": "25854017", "label": "objective", "text": "To explore the effects of early intervention of acupuncture on urinary function reconstruction of neurogenic bladder after spinal cord injury , so as to find the optimal treatment timing of acupuncture .", "sentence_id": 0}
+{"abstract_id": "25854017", "label": "methods", "text": "Fifty-three patients of neurogenic bladder after spinal cord injury were randomly divided into a prior-to-catheter group ( @ cases ) and a posterior-to-catheter group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "25854017", "label": "methods", "text": "For the prior-to-catheter group , one week before the removal of catheter , acupoints on the abdomen and back such as Guanyuan ( CV @ ) , Zhongji ( CV @ ) , Baliao ( Shangliao ( BL @ ) , Ciliao ( BL @ ) , Zhongliao ( BL @ ) , Xialiao ( BL @ ) , Jiaji ( EX-B @ ) and acupoints at distal end such as Zusanli ( ST @ ) and Sanyinjiao ( SP @ ) were selected ; after the catheter removal , simple method .", "sentence_id": 2}
+{"abstract_id": "25854017", "label": "methods", "text": "of water column was used to measure bladder capacity pressure to classify the type of bladder , and then different acupuncture manipulations were given ; intermittent catheterization was performed if condition was allowed .", "sentence_id": 3}
+{"abstract_id": "25854017", "label": "methods", "text": "The posterior-to-catheter group applied identical treatment after removal of catheter as the prior-to-catheter group .", "sentence_id": 4}
+{"abstract_id": "25854017", "label": "methods", "text": "The treatment was given @ times per week ; after one-month treatment , five aspects including the time of first effective urination , time of establishing reflex urination , average residual volume of urine , time of residual urine less than @ mL and quality of life ( QOL ) were evaluated .", "sentence_id": 5}
+{"abstract_id": "25854017", "label": "results", "text": "After treatment , the time of first effective urination , time of establishing reflex urination , average residual volume of urine and time of residual urineless than @ mL in the prior-to-catheter group were all superior to those in the posterior-to-catheter group ( all P < @ ) ; the score of QOL was improved in two groups after treatment ( both P < @ ) , but the difference between two groups was not statistically significant ( P > @ ) ; each index of urination function was not significant among patients with different injured segments of spinal cord ( all P > @ ) .", "sentence_id": 6}
+{"abstract_id": "25854017", "label": "conclusions", "text": "The early intervention of acupuncture ( prior to catheter ) has obvious improving function on establishing balanced bladder in patients with neurogenic bladder after spinal cord injury , which is superior to acupuncture intervention after removal of catheter , however , the effects of different injured segments on establishing balanced bladder are not different .", "sentence_id": 7}
+{"abstract_id": "24289994", "label": "objective", "text": "To identify a group of deliveries to mothers with indicators of subfertility ( SUBFERTILITY ) .", "sentence_id": 0}
+{"abstract_id": "24289994", "label": "methods", "text": "Longitudinal cohort study .", "sentence_id": 1}
+{"abstract_id": "24289994", "label": "methods", "text": "Hospital .", "sentence_id": 2}
+{"abstract_id": "24289994", "label": "methods", "text": "A total of @,@ deliveries to Massachusetts mothers in a Massachusetts hospital between July @ , @ , and December @ , @ .", "sentence_id": 3}
+{"abstract_id": "24289994", "label": "methods", "text": "None .", "sentence_id": 4}
+{"abstract_id": "24289994", "label": "methods", "text": "Subfertility was defined by an indication on a current or past birth certificate or hospital utilization data of infertility or assisted reproductive technology ( ART ) cycle before index delivery and no indication of ART use with index delivery .", "sentence_id": 5}
+{"abstract_id": "24289994", "label": "results", "text": "Initially , @,@ deliveries met the inclusion criteria for SUBFERTILITY ( @,@ from birth certificates , @,@ from hospital data , @,@ from prior ART treatment ) .", "sentence_id": 6}
+{"abstract_id": "24289994", "label": "results", "text": "Removing deliveries from more than one data source resulted in @,@ unique deliveries .", "sentence_id": 7}
+{"abstract_id": "24289994", "label": "results", "text": "Removing deliveries resulting from ART treatments left @,@ deliveries in the SUBFERTILITY category .", "sentence_id": 8}
+{"abstract_id": "24289994", "label": "results", "text": "Demographic analysis indicated that deliveries in SUBFERTILITY were more similar to those in the ART population than to those in the fertile population .", "sentence_id": 9}
+{"abstract_id": "24289994", "label": "conclusions", "text": "We have demonstrated the feasibility of using existing population-based linked public health data sets to identify SUBFERTILITY deliveries , and we have used ART data to distinguish ART and SUBFERTILITY births .", "sentence_id": 10}
+{"abstract_id": "24289994", "label": "conclusions", "text": "The SUBFERTILITY category can serve as a comparison group of subfertile patients for studies of ART delivery and longitudinal health outcomes .", "sentence_id": 11}
+{"abstract_id": "24597472", "label": "background", "text": "Idrabiotaparinux , a long-acting inhibitor of factor Xa , was shown to be effective in the treatment of patients with venous thromboembolism .", "sentence_id": 0}
+{"abstract_id": "24597472", "label": "objective", "text": "To assess non-inferiority for the efficacy of idrabiotaparinux versus warfarin in patients with atrial fibrillation ( AF ) at risk of stroke and systemic embolism .", "sentence_id": 1}
+{"abstract_id": "24597472", "label": "objective", "text": "Bleeding was also assessed .", "sentence_id": 2}
+{"abstract_id": "24597472", "label": "methods", "text": "This randomized , double-blind trial enrolled patients with electrocardiogram-documented AF .", "sentence_id": 3}
+{"abstract_id": "24597472", "label": "methods", "text": "Idrabiotaparinux was administered weekly via subcutaneous injection , and warfarin was administered daily with dose adjustment to maintain the international normalized ratio between @ and @ .", "sentence_id": 4}
+{"abstract_id": "24597472", "label": "methods", "text": "Each idrabiotaparinux injection was @ mg for the first @ weeks , followed by @ mg thereafter , except in patients with a creatinine clearance of @-@ mL min ( -@ ) or aged @ years .", "sentence_id": 5}
+{"abstract_id": "24597472", "label": "methods", "text": "The patients received @ mg after the first @ weeks .", "sentence_id": 6}
+{"abstract_id": "24597472", "label": "methods", "text": "The efficacy outcome was the composite of all fatal or non-fatal strokes and systemic embolism .", "sentence_id": 7}
+{"abstract_id": "24597472", "label": "methods", "text": "The safety outcome was clinically relevant bleeding ( major and clinically relevant non-major bleeding ) .", "sentence_id": 8}
+{"abstract_id": "24597472", "label": "results", "text": "The study was terminated prematurely by the sponsor for strategic/commercial , not scientific , reasons , with @ % of the planned number of patients included and an average duration of treatment of @ days .", "sentence_id": 9}
+{"abstract_id": "24597472", "label": "results", "text": "Of the @ idrabiotaparinux recipients , @ developed stroke or systemic embolism ( @ % per year ) , whereas this occurred in @ of the @ warfarin patients ( @ % per year , hazard ratio @ , @ % confidence interval @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24597472", "label": "results", "text": "The annual incidence of bleeding was @ % in the idrabiotaparinux and @ % in the warfarin group ( hazard ratio @ , @ % confidence interval @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24597472", "label": "conclusions", "text": "If anything , despite its early termination , the idrabiotaparinux regimen studied suggested a comparable efficacy to dose-adjusted warfarin , with a lower bleeding risk .", "sentence_id": 12}
+{"abstract_id": "25350546", "label": "background", "text": "Low rates of adherence to artemisinin-based combination therapy ( ACT ) regimens increase the risk of treatment failure and may lead to drug resistance , threatening the sustainability of current anti-malarial efforts .", "sentence_id": 0}
+{"abstract_id": "25350546", "label": "background", "text": "We assessed the impact of text message reminders on adherence to ACT regimens .", "sentence_id": 1}
+{"abstract_id": "25350546", "label": "methods", "text": "Health workers at hospitals , clinics , pharmacies , and other stationary ACT distributors in Tamale , Ghana provided flyers advertising free mobile health information to individuals receiving malaria treatment .", "sentence_id": 2}
+{"abstract_id": "25350546", "label": "methods", "text": "The messaging system automatically randomized self-enrolled individuals to the control group or the treatment group with equal probability ; those in the treatment group were further randomly assigned to receive a simple text message reminder or the simple reminder plus an additional statement about adherence in @-hour intervals .", "sentence_id": 3}
+{"abstract_id": "25350546", "label": "methods", "text": "The main outcome was self-reported adherence based on follow-up interviews occurring three days after treatment initiation .", "sentence_id": 4}
+{"abstract_id": "25350546", "label": "methods", "text": "We estimated the impact of the messages on treatment completion using logistic regression .", "sentence_id": 5}
+{"abstract_id": "25350546", "label": "results", "text": "@ individuals enrolled in both the study and the text reminder system .", "sentence_id": 6}
+{"abstract_id": "25350546", "label": "results", "text": "Among individuals in the control group , @ % took the full course of treatment .", "sentence_id": 7}
+{"abstract_id": "25350546", "label": "results", "text": "The simple text message reminders increased the odds of adherence ( adjusted OR @ , @ % CI -LSB- @ to @ -RSB- , p-value @ ) .", "sentence_id": 8}
+{"abstract_id": "25350546", "label": "results", "text": "Receiving an additional message did not result in a significant change in adherence ( adjusted OR @ , @ % CI -LSB- @ to @ -RSB- , p-value @ ) .", "sentence_id": 9}
+{"abstract_id": "25350546", "label": "conclusions", "text": "The results of this study suggest that a simple text message reminder can increase adherence to antimalarial treatment and that additional information included in messages does not have a significant impact on completion of ACT treatment .", "sentence_id": 10}
+{"abstract_id": "25350546", "label": "conclusions", "text": "Further research is needed to develop the most effective text message content and frequency .", "sentence_id": 11}
+{"abstract_id": "26072348", "label": "objective", "text": "We sought to define normative visual field ( VF ) values for children using common clinical test protocols for kinetic and static perimetry .", "sentence_id": 0}
+{"abstract_id": "26072348", "label": "methods", "text": "Prospective , observational study .", "sentence_id": 1}
+{"abstract_id": "26072348", "label": "methods", "text": "We recruited @ children aged @ to @ years without any ophthalmic condition that would affect the VF ( controls ) from pediatric clinics at Moorfields Eye Hospital .", "sentence_id": 2}
+{"abstract_id": "26072348", "label": "methods", "text": "Children performed perimetric assessments in a randomized order using Goldmann and Octopus kinetic perimetry , and Humphrey static perimetry ( Swedish Interactive Thresholding Algorithm -LSB- SITA -RSB- @-@ FAST ) , in a single sitting , using standardized clinical protocols , with assessment by a single examiner .", "sentence_id": 3}
+{"abstract_id": "26072348", "label": "methods", "text": "Unreliable results ( assessed qualitatively ) were excluded from the normative data analysis .", "sentence_id": 4}
+{"abstract_id": "26072348", "label": "methods", "text": "Linear , piecewise , and quantile mixed-effects regression models were used .", "sentence_id": 5}
+{"abstract_id": "26072348", "label": "methods", "text": "We developed a method to display age-specific normative isopters graphically on a VF plot to aid interpretation .", "sentence_id": 6}
+{"abstract_id": "26072348", "label": "methods", "text": "Summary measures and graphical plots describing normative VF data for @ common perimetric tests .", "sentence_id": 7}
+{"abstract_id": "26072348", "label": "results", "text": "Visual field area increased with age on testing with Goldmann isopters III@e , I@e , and I@e ( linear regression ; P < @ ) and for Octopus isopters III@e and I@e ( linear regression ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "26072348", "label": "results", "text": "Visual field development occurs predominately in the inferotemporal field .", "sentence_id": 9}
+{"abstract_id": "26072348", "label": "results", "text": "Humphrey mean deviation ( MD ) showed an increase of @ decibels ( dB ; @ % CI , @-@ @ ) MD per year up to @ years of age , when adult MD values were reached and thereafter maintained .", "sentence_id": 10}
+{"abstract_id": "26072348", "label": "conclusions", "text": "Visual field size and sensitivity increase with age in patterns that are specific to the perimetric approach used .", "sentence_id": 11}
+{"abstract_id": "26072348", "label": "conclusions", "text": "These developmental changes should be accounted for when interpreting perimetric test results in children , particularly when monitoring change over time .", "sentence_id": 12}
+{"abstract_id": "25005346", "label": "background", "text": "Guidelines for SPECT myocardial perfusion imaging ( MPI ) traditionally recommend a fixed tracer dose .", "sentence_id": 0}
+{"abstract_id": "25005346", "label": "background", "text": "Yet , clinical practice shows degraded image quality in heavier patients .", "sentence_id": 1}
+{"abstract_id": "25005346", "label": "background", "text": "The aim was to optimize and validate the tracer dose and scan time to obtain a constant image quality less dependent on patients ' physical characteristics .", "sentence_id": 2}
+{"abstract_id": "25005346", "label": "methods", "text": "@ patients underwent Cadmium Zinc Telluride ( CZT ) - SPECT stress MPI using a fixed Tc-@m-tetrofosmin tracer dose .", "sentence_id": 3}
+{"abstract_id": "25005346", "label": "methods", "text": "Image quality was scored by three physicians on a @-point grading scale and related to the number of photon counts normalized to tracer dose and scan time .", "sentence_id": 4}
+{"abstract_id": "25005346", "label": "methods", "text": "Counts were correlated with various patient-specific parameters dealing with patient size and weight to find the best predicting parameter .", "sentence_id": 5}
+{"abstract_id": "25005346", "label": "methods", "text": "From these data , a formula to provide constant image quality was derived , and subsequently tested in @ new patients .", "sentence_id": 6}
+{"abstract_id": "25005346", "label": "results", "text": "Degradation in image quality and photon counts was observed for heavier patients for all patients ' specific parameters ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25005346", "label": "results", "text": "We found body weight to be the best-predicting parameter for image quality and derived a new dose formula .", "sentence_id": 8}
+{"abstract_id": "25005346", "label": "results", "text": "After applying this new body weight-depended tracer dose and scan time in a new group , image quality was found to be constant ( P > @ ) in all patients .", "sentence_id": 9}
+{"abstract_id": "25005346", "label": "conclusions", "text": "Also in CZT SPECT image quality decreases with weight .", "sentence_id": 10}
+{"abstract_id": "25005346", "label": "conclusions", "text": "The use of a tracer dose and scan time that depends linearly on patient 's body weight corrected for the varying image quality in CZT-SPECT MPI .", "sentence_id": 11}
+{"abstract_id": "25005346", "label": "conclusions", "text": "This leads to better radiation exposure justification .", "sentence_id": 12}
+{"abstract_id": "24924991", "label": "background", "text": "No randomised study has shown whether stratification of treatment by minimal residual disease ( MRD ) response improves outcome in children and young people with acute lymphoblastic leukaemia ( ALL ) .", "sentence_id": 0}
+{"abstract_id": "24924991", "label": "background", "text": "We assessed whether children and young people with clinical standard and intermediate-risk ALL who have persistent MRD at the end of induction therapy benefit from augmented post-remission therapy .", "sentence_id": 1}
+{"abstract_id": "24924991", "label": "methods", "text": "Between Oct @ , @ , and June @ , @ , we enrolled eligible patients aged @-@ years and initially categorised them into clinical standard-risk , intermediate-risk , and high-risk groups on the basis of a combination of National Cancer Institute criteria , cytogenetics , and early morphological response to induction therapy .", "sentence_id": 2}
+{"abstract_id": "24924991", "label": "methods", "text": "Clinical standard-risk and intermediate-risk patients with MRD of @ % or higher at day @ of induction ( MRD high risk ) were randomly assigned ( @:@ ) to standard therapy ( treatment regimens A and B ) or augmented post-remission therapy ( regimen C ) .", "sentence_id": 3}
+{"abstract_id": "24924991", "label": "methods", "text": "Compared with standard therapy , the augmented treatment regimen ( regimen C ) included an additional eight doses of pegylated asparaginase , @ doses of vincristine , and escalated-dose intravenous methotrexate without folinic acid rescue during interim maintenance courses .", "sentence_id": 4}
+{"abstract_id": "24924991", "label": "methods", "text": "Computer randomisation was used for treatment allocation and was balanced for sex , age ( < @ years vs @ years ) , and white blood cell count at diagnosis ( < @ ( @ ) / L vs @ ( @ ) / L ) by minimisation .", "sentence_id": 5}
+{"abstract_id": "24924991", "label": "methods", "text": "Patients , clinicians , and data analysts were not masked to treatment allocation .", "sentence_id": 6}
+{"abstract_id": "24924991", "label": "methods", "text": "The primary outcomes were event-free survival and overall survival .", "sentence_id": 7}
+{"abstract_id": "24924991", "label": "methods", "text": "Analyses were by intention to treat .", "sentence_id": 8}
+{"abstract_id": "24924991", "label": "methods", "text": "This trial is registered with Current Controlled Trials , number ISRCTN@ .", "sentence_id": 9}
+{"abstract_id": "24924991", "label": "results", "text": "@ MRD high-risk patients were randomly assigned to receive standard ( n = @ ) or augmented ( n = @ ) post-remission therapy .", "sentence_id": 10}
+{"abstract_id": "24924991", "label": "results", "text": "After a median follow-up of @ months ( IQR @-@ ) , @-year event-free survival was better in the augmented treatment group ( @ % -LSB- @ % CI @-@ -RSB- ) than in the standard group ( @ % -LSB- @-@ -RSB- ; odds ratio -LSB- OR -RSB- @ -LSB- @ % CI @-@ -RSB- , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24924991", "label": "results", "text": "Overall survival at @ years was numerically , but not significantly , higher in the augmented treatment group ( @ % -LSB- @ % CI @-@ -RSB- ) than in the standard therapy group ( @ % -LSB- @-@ -RSB- ; OR @ -LSB- @ % CI @-@ -RSB- , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24924991", "label": "results", "text": "More adverse events occurred in the augmented treatment group than in the standard group ( asparaginase-related hypersensitivity in @ -LSB- @ % -RSB- in the augmented group vs two -LSB- @ % -RSB- in the standard group and asparaginase-related pancreatitis in eight -LSB- @ % -RSB- vs one -LSB- @ % -RSB- ; intravenous methotrexate-related mucositis in @ -LSB- @ % -RSB- vs three -LSB- @ % -RSB- and methotrexate-related stomatitis in @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "24924991", "label": "conclusions", "text": "Our findings suggest that children and young people with acute lymphoblastic leukaemia and @ % or more MRD at the end of remission induction therapy could benefit from augmented post-remission therapy .", "sentence_id": 14}
+{"abstract_id": "24924991", "label": "conclusions", "text": "However , the asparaginase and intravenous methotrexate used in the augmented treatment regimen is associated with more adverse events than is the standard post-remission treatment regimen .", "sentence_id": 15}
+{"abstract_id": "24571588", "label": "background", "text": "Quantification of molecular cell processes is important for prognostication and treatment individualization of head and neck cancer ( HNC ) .", "sentence_id": 0}
+{"abstract_id": "24571588", "label": "background", "text": "However , individual tumor comparison can show discord in upregulation similarities when analyzing multiple biological mechanisms .", "sentence_id": 1}
+{"abstract_id": "24571588", "label": "background", "text": "Elaborate tumor characterization , integrating multiple pathways reflecting intrinsic and microenvironmental properties , may be beneficial to group most uniform tumors for treatment modification schemes .", "sentence_id": 2}
+{"abstract_id": "24571588", "label": "background", "text": "The goal of this study was to systematically analyze if immunohistochemical ( IHC ) assessment of molecular markers , involved in treatment resistance , and @F-FDG PET parameters could accurately distinguish separate HNC tumors .", "sentence_id": 3}
+{"abstract_id": "24571588", "label": "methods", "text": "Several imaging parameters and texture features for @F-FDG small-animal PET and immunohistochemical markers related to metabolism , hypoxia , proliferation and tumor blood perfusion were assessed within groups of BALB/c nu/nu mice xenografted with @ human HNC models .", "sentence_id": 4}
+{"abstract_id": "24571588", "label": "methods", "text": "Classification methods were used to predict tumor line based on sets of parameters .", "sentence_id": 5}
+{"abstract_id": "24571588", "label": "results", "text": "We found that @F-FDG PET could not differentiate between the tumor lines .", "sentence_id": 6}
+{"abstract_id": "24571588", "label": "results", "text": "On the contrary , combined IHC parameters could accurately allocate individual tumors to the correct model .", "sentence_id": 7}
+{"abstract_id": "24571588", "label": "results", "text": "From @ analyzed IHC parameters , a cluster of @ random parameters already classified @ % correctly .", "sentence_id": 8}
+{"abstract_id": "24571588", "label": "results", "text": "Combining all PET/IHC characteristics resulted in the highest tumor line classification accuracy ( @ % ; cross validation @ % ) , which was just @ % higher ( p = @-@ ) than the performance of the IHC parameter/feature based model .", "sentence_id": 9}
+{"abstract_id": "24571588", "label": "conclusions", "text": "With a select set of IHC markers representing cellular processes of metabolism , proliferation , hypoxia and perfusion , one can reliably distinguish between HNC tumor lines .", "sentence_id": 10}
+{"abstract_id": "24571588", "label": "conclusions", "text": "Addition of @F-FDG PET improves classification accuracy of IHC to a significant yet minor degree .", "sentence_id": 11}
+{"abstract_id": "24571588", "label": "conclusions", "text": "These results may form a basis for development of tumor characterization models for treatment allocation purposes .", "sentence_id": 12}
+{"abstract_id": "25223462", "label": "background", "text": "The EACH study assessed the efficacy of oxaliplatin , @-fluorouracil , and leucovorin ( the FOLFOX@ regimen ) compared with doxorubicin alone in terms of overall survival ( OS ) , progression-free survival ( PFS ) , and safety in patients with advanced hepatocellular carcinoma ( HCC ) .", "sentence_id": 0}
+{"abstract_id": "25223462", "label": "background", "text": "We present the results of this study in Chinese patients .", "sentence_id": 1}
+{"abstract_id": "25223462", "label": "methods", "text": "In a multicenter , open-label , randomized , phase III study ( NCT@ ) , @ patients ( @ patients from the People 's Republic of China ) were randomized @:@ to receive either FOLFOX@ or doxorubicin until disease progression , intolerable toxicity , death , or surgical resection .", "sentence_id": 2}
+{"abstract_id": "25223462", "label": "results", "text": "Baseline characteristics of the Chinese patients enrolled in the study were similar for the @ treatment groups and in comparison with the whole EACH cohort .", "sentence_id": 3}
+{"abstract_id": "25223462", "label": "results", "text": "Median OS at the prespecified time point of treatment was @ months with FOLFOX@ and @ months with doxorubicin ( hazard ratio -LSB- HR -RSB- : @ ; @ % confidence interval -LSB- CI -RSB- :@ -@ ; p = @ ) .", "sentence_id": 4}
+{"abstract_id": "25223462", "label": "results", "text": "At the end of the follow-up period , median OS was @ months with FOLFOX@ and @ months with doxorubicin ( HR : @ ; @ % CI :@ -@ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25223462", "label": "results", "text": "Median PFS was @ months and @ months in the FOLFOX@ and doxorubicin groups , respectively ( HR : @ ; @ % CI :@ -@ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25223462", "label": "results", "text": "The response rate ( RR ) and disease control rate ( DCR ) were significantly higher in the FOLFOX@ group than in the doxorubicin group ( RR : @ % vs. @ % , p = @ ; DCR : @ % vs. @ % , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25223462", "label": "results", "text": "Hematological toxicity was more frequently reported in the FOLFOX@ group .", "sentence_id": 8}
+{"abstract_id": "25223462", "label": "conclusions", "text": "For Chinese HCC patients enrolled in the EACH study , FOLFOX@ significantly improved the RR and DCR and prolonged survival compared with doxorubicin .", "sentence_id": 9}
+{"abstract_id": "25223462", "label": "conclusions", "text": "Systemic chemotherapy with oxaliplatin-based regimens may play an important role in the treatment of Chinese patients with advanced HCC .", "sentence_id": 10}
+{"abstract_id": "24843061", "label": "objective", "text": "Children are vulnerable to diet inadequacies , which may affect immune function .", "sentence_id": 0}
+{"abstract_id": "24843061", "label": "objective", "text": "Our objective was to determine if a follow-up formula ( FUF ) containing DHA , the prebiotics PDX and GOS , and yeast - glucan affects incidence of respiratory infections and diarrheal disease in healthy children .", "sentence_id": 1}
+{"abstract_id": "24843061", "label": "methods", "text": "In a double-blind , randomized , controlled , prospective trial , @-@ year old children were fed @ servings per day of either a FUF with @ mg DHA , @ g PDX/GOS , and @ mg yeast - glucan per serving or an unfortified , cow 's milk-based beverage ( control ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24843061", "label": "methods", "text": "Fecal and blood samples were collected to assess immune markers and iron/zinc status .", "sentence_id": 3}
+{"abstract_id": "24843061", "label": "methods", "text": "Incidence of acute respiratory infections ( ARI ) , diarrheal disease , and antibiotic treatment were obtained from medical records .", "sentence_id": 4}
+{"abstract_id": "24843061", "label": "results", "text": "The FUF group had fewer episodes and shorter duration of ARI ( mean days -LSB- SE -RSB- ; control = @ -LSB- @ -RSB- ; FUF = @ -LSB- @ -RSB- ; P = @ ) , less antibiotic use ( n -LSB- % -RSB- ; control = @ -LSB- @ % -RSB- ; FUF = @ -LSB- @ % -RSB- ; P = @ ) , and fewer missed days of day care due to illness .", "sentence_id": 5}
+{"abstract_id": "24843061", "label": "results", "text": "No diarrheal disease was diagnosed in either group .", "sentence_id": 6}
+{"abstract_id": "24843061", "label": "results", "text": "The FUF group had higher interleukin-@ and white blood cell count at the end of the study .", "sentence_id": 7}
+{"abstract_id": "24843061", "label": "results", "text": "There were no differences in hemoglobin , serum ferritin and zinc , or fecal secretory immunoglobulin A.", "sentence_id": 8}
+{"abstract_id": "24843061", "label": "conclusions", "text": "Daily consumption of a FUF was associated with fewer episodes and shorter duration of ARI , as well as less antibiotic use .", "sentence_id": 9}
+{"abstract_id": "24843061", "label": "conclusions", "text": "The children who consumed the FUF had increased interleukin-@ and white blood cells , suggesting an antiinflammatory mechanism and/or an increase of effector immune cells .", "sentence_id": 10}
+{"abstract_id": "24998121", "label": "background", "text": "In the PROTECT AF ( Watchman Left Atrial Appendage Closure Technology for Embolic Protection in Patients With Atrial Fibrillation ) trial that evaluated patients with nonvalvular atrial fibrillation ( NVAF ) , left atrial appendage ( LAA ) occlusion was noninferior to warfarin for stroke prevention , but a periprocedural safety hazard was identified .", "sentence_id": 0}
+{"abstract_id": "24998121", "label": "objective", "text": "The goal of this study was to assess the safety and efficacy of LAA occlusion for stroke prevention in patients with NVAF compared with long-term warfarin therapy .", "sentence_id": 1}
+{"abstract_id": "24998121", "label": "methods", "text": "This randomized trial further assessed the efficacy and safety of the Watchman device .", "sentence_id": 2}
+{"abstract_id": "24998121", "label": "methods", "text": "Patients with NVAF who had a CHADS@ ( congestive heart failure , hypertension , age > @ years , diabetes mellitus , and previous stroke/transient ischemic attack ) score @ or @ and another risk factor were eligible .", "sentence_id": 3}
+{"abstract_id": "24998121", "label": "methods", "text": "Patients were randomly assigned ( in a @:@ ratio ) to undergo LAA occlusion and subsequent discontinuation of warfarin ( intervention group , n = @ ) or receive chronic warfarin therapy ( control group , n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24998121", "label": "methods", "text": "Two efficacy and @ safety coprimary endpoints were assessed .", "sentence_id": 5}
+{"abstract_id": "24998121", "label": "results", "text": "At @ months , the rate of the first coprimary efficacy endpoint ( composite of stroke , systemic embolism -LSB- SE -RSB- , and cardiovascular/unexplained death ) was @ in the device group versus @ in the control group ( rate ratio @ -LSB- @ % credible interval ( CrI ) : @ to @ -RSB- ) and did not achieve the prespecified criteria noninferiority ( upper boundary of @ % CrI @ ) .", "sentence_id": 6}
+{"abstract_id": "24998121", "label": "results", "text": "The rate for the second coprimary efficacy endpoint ( stroke or SE > @ days ' postrandomization ) was @ versus @ ( risk difference @ -LSB- @ % CrI : -@ to @ -RSB- ) , achieving noninferiority .", "sentence_id": 7}
+{"abstract_id": "24998121", "label": "results", "text": "Early safety events occurred in @ % of the Watchman arm , significantly lower than in PROTECT AF , satisfying the pre-specified safety performance goal .", "sentence_id": 8}
+{"abstract_id": "24998121", "label": "results", "text": "Using a broader , more inclusive definition of adverse effects , these still were lower in PREVAIL ( Watchman LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy ) trial than in PROTECT AF ( @ % vs. @ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24998121", "label": "results", "text": "Pericardial effusions requiring surgical repair decreased from @ % to @ % ( p = @ ) , and those requiring pericardiocentesis decreased from @ % to @ % ( p = @ ) , although the number of events was small .", "sentence_id": 10}
+{"abstract_id": "24998121", "label": "conclusions", "text": "In this trial , LAA occlusion was noninferior to warfarin for ischemic stroke prevention or SE > @ days ' post-procedure .", "sentence_id": 11}
+{"abstract_id": "24998121", "label": "conclusions", "text": "Although noninferiority was not achieved for overall efficacy , event rates were low and numerically comparable in both arms .", "sentence_id": 12}
+{"abstract_id": "24998121", "label": "conclusions", "text": "Procedural safety has significantly improved .", "sentence_id": 13}
+{"abstract_id": "24998121", "label": "conclusions", "text": "This trial provides additional data that LAA occlusion is a reasonable alternative to warfarin therapy for stroke prevention in patients with NVAF who do not have an absolute contraindication to short-term warfarin therapy .", "sentence_id": 14}
+{"abstract_id": "25524481", "label": "objective", "text": "To compare the clinical outcome and complications of high viscosity and low viscosity poly-methyl methacrylate bone cement PVP for severe OVCFs .", "sentence_id": 0}
+{"abstract_id": "25524481", "label": "methods", "text": "From December @ to December @ , @ patients with severe OVCFs were randomly assigned to either group H using high viscosity cement ( n = @ ) or group L using low viscosity cement ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25524481", "label": "methods", "text": "The clinical outcomes were assessed by the Visual Analog Scale ( VAS ) , Oswestry Disability Index ( ODI ) , Short Form-@ General Health Survey ( SF-@ ) , kyphosis Cobb 's angle , vertebral height , and complications .", "sentence_id": 2}
+{"abstract_id": "25524481", "label": "results", "text": "Significant improvement in the VAS , ODI , SF-@ scores , kyphosis Cobb 's angle , and vertebral height were noted in both the groups , and there were no significant differences between the two groups .", "sentence_id": 3}
+{"abstract_id": "25524481", "label": "results", "text": "Cement leakage was seen less in group H. Postoperative assessment using computed tomography identified cement leakage in @ of @ ( @ % ) vertebrae in group H and in @ of @ ( @ % ) vertebrae in group L ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25524481", "label": "conclusions", "text": "The PVP using high viscosity bone cement can provide the same clinical outcome and fewer complications compared with PVP using low viscosity bone cement .", "sentence_id": 5}
+{"abstract_id": "24456624", "label": "background", "text": "Therapeutic vaccination is a promising novel approach to treat HIV-@ infected people by boosting or redirecting immune system to neutralize critical HIV-@ antigens whose biological effects are relevant in the context of viral pathogenesis .", "sentence_id": 0}
+{"abstract_id": "24456624", "label": "background", "text": "With the aim to induce neutralizing antibodies to the matrix protein p@ we have developed a peptide-based immunogen ( AT@-KLH ) and evaluated its safety and immunogenicity .", "sentence_id": 1}
+{"abstract_id": "24456624", "label": "methods", "text": "Twenty four asymptomatic HAART-treated HIV-@ + patients were enrolled in a phase I clinical study and were randomized to three groups : @ groups were treated with five IM injection ( Arm A : @g/inoculation ; Arm B : @g/inoculation ) at day ( D ) D@ , D@ , D@ , D@ and D@ ; the control group ( Arm C ) were not injected .", "sentence_id": 2}
+{"abstract_id": "24456624", "label": "methods", "text": "Safety was assessed by monitoring local and systemic adverse events ( AEs ) , recorded till D@ .", "sentence_id": 3}
+{"abstract_id": "24456624", "label": "methods", "text": "Evaluation of immunogenicity was by titering antibodies at D@ , D@ , D@ , D@ , D@ , D@ , D@ , D@ and D@ using ELISA .", "sentence_id": 4}
+{"abstract_id": "24456624", "label": "results", "text": "In all , @ local and systemic AEs were reported across the three groups .", "sentence_id": 5}
+{"abstract_id": "24456624", "label": "results", "text": "Most were mild and resolved without sequelae .", "sentence_id": 6}
+{"abstract_id": "24456624", "label": "results", "text": "Also the few unsolicited events , deemed unrelated to the study vaccines , caused no problems .", "sentence_id": 7}
+{"abstract_id": "24456624", "label": "results", "text": "No significant changes in the routine laboratory parameters , CD@ T-cell count or HIV-@ viremia were found .", "sentence_id": 8}
+{"abstract_id": "24456624", "label": "results", "text": "At the time of enrollment @ out of @ patients had no anti-AT@ antibodies , whereas @ exhibited anti-p@ antibodies .", "sentence_id": 9}
+{"abstract_id": "24456624", "label": "results", "text": "Irrespective of the presence of preimmunization antibodies , all subjects developed high titers of anti-AT@ antibodies ( GM @ ) in response to both AT@-KLH doses .", "sentence_id": 10}
+{"abstract_id": "24456624", "label": "results", "text": "These antibodies were also capable of recognizing AT@ within the p@ framework .", "sentence_id": 11}
+{"abstract_id": "24456624", "label": "conclusions", "text": "The AT@ peptide-based approach has allowed to redirect HAART-treated patients ' humoral responses toward a previously untargeted hotspot of functional activity .", "sentence_id": 12}
+{"abstract_id": "24456624", "label": "conclusions", "text": "Overall , the tested AT@-KLH doses were safe and well tolerated , supporting further exploration of AT@-KLH as an HIV-@ therapeutic vaccine candidate .", "sentence_id": 13}
+{"abstract_id": "26089332", "label": "objective", "text": "Hypertensive patients with electrocardiographic left ventricular hypertrophy are at increased risk of all-cause and cardiovascular death .", "sentence_id": 0}
+{"abstract_id": "26089332", "label": "objective", "text": "Lowering blood pressure ( BP ) after stroke reduces the risk of recurrent stroke , but recent data suggest that lower systolic BP ( SBP ) measured @ years after stroke is associated with increased mortality .", "sentence_id": 1}
+{"abstract_id": "26089332", "label": "objective", "text": "Whether lower SBP is associated with increased short-term mortality after stroke in hypertensive patients is unclear .", "sentence_id": 2}
+{"abstract_id": "26089332", "label": "methods", "text": "All-cause and cardiovascular mortality were examined in relation to average on-treatment SBP after stroke in @ hypertensive patients with electrocardiographic left ventricular hypertrophy randomly assigned to losartan - or atenolol-based treatment who had new strokes during follow-up .", "sentence_id": 3}
+{"abstract_id": "26089332", "label": "methods", "text": "Patients with on-treatment SBP < @ mm Hg ( lowest tertile ) and SBP > @ ( highest tertile ) were compared with patients with average SBP between @ and @ .", "sentence_id": 4}
+{"abstract_id": "26089332", "label": "results", "text": "During @ years mean follow-up after incident stroke , @ patients ( @ % ) died , @ ( @ % ) from cardiovascular causes .", "sentence_id": 5}
+{"abstract_id": "26089332", "label": "results", "text": "In multivariate Cox analyses , adjusting for significant univariate predictors of mortality , compared with average SBP between @ and @ , an average SBP < @ was a significant predictor of all-cause ( hazard ratio , @ ; @ % confidence interval , @-@ @ ) and cardiovascular mortality ( hazard ratio , @ ; @ % confidence interval , @-@ @ ) , whereas patients who had an average SBP > @ had no significant increased risk of death .", "sentence_id": 6}
+{"abstract_id": "26089332", "label": "conclusions", "text": "Lower achieved SBP ( < @ mm Hg ) is associated with a significantly increased risk of cardiovascular and all-cause mortality after initial stroke in hypertensive patients during short-term follow-up .", "sentence_id": 7}
+{"abstract_id": "26089332", "label": "conclusions", "text": "Further study is required to determine ideal SBP goals after stroke .", "sentence_id": 8}
+{"abstract_id": "25607118", "label": "background", "text": "LifeWave Energy Enhancer ( LEE ) patches ( LifeWave Corp , San Diego , CA , USA ) on skin produce some changes that are consistent with increased energy production , but little is known about their effects on cortisol concentrations or the peripheral circulation .", "sentence_id": 0}
+{"abstract_id": "25607118", "label": "objective", "text": "The study intended to assess the effects of LEE patches on salivary cortisol , peripheral circulation , and psychological measures on healthy adults .", "sentence_id": 1}
+{"abstract_id": "25607118", "label": "methods", "text": "A double-blind , placebo-controlled , randomized pilot study was performed .", "sentence_id": 2}
+{"abstract_id": "25607118", "label": "methods", "text": "Measurements were made in the laboratory at Mind-Body-Science ( Tucson , AZ , USA ) .", "sentence_id": 3}
+{"abstract_id": "25607118", "label": "methods", "text": "Participants collected some of the saliva samples at work or home .", "sentence_id": 4}
+{"abstract_id": "25607118", "label": "methods", "text": "To obtain pilot data , @ healthy individuals with no chronic conditions were recruited-@ males and @ females-aged @-@ y.", "sentence_id": 5}
+{"abstract_id": "25607118", "label": "methods", "text": "Participants completed baseline psychological questionnaires and provided saliva samples for hormonal analysis .", "sentence_id": 6}
+{"abstract_id": "25607118", "label": "methods", "text": "The next day , fingertip microvascular perfusion was measured , LEE or placebo patches were applied to participants ' wrists , and perfusion scans were repeated , first immediately after and then @ min after application of the patch .", "sentence_id": 7}
+{"abstract_id": "25607118", "label": "methods", "text": "Saliva samples were collected , and questionnaires were completed .", "sentence_id": 8}
+{"abstract_id": "25607118", "label": "methods", "text": "Participants returned at noon and @:@ PM for further scans , and at the end of that time , the patches were removed .", "sentence_id": 9}
+{"abstract_id": "25607118", "label": "methods", "text": "The protocol was repeated the following day using new patches .", "sentence_id": 10}
+{"abstract_id": "25607118", "label": "methods", "text": "The research team analyzed the saliva samples for levels of cortisol and measured the percentage changes in cutaneous microvascular perfusion .", "sentence_id": 11}
+{"abstract_id": "25607118", "label": "methods", "text": "The participants completed the energy visual analog scales ( eVASs ) and the Marlowe-Crowne Social Desirability survey .", "sentence_id": 12}
+{"abstract_id": "25607118", "label": "results", "text": "After the first patch application , the active group showed significantly higher cortisol concentrations than the placebo group , both at noon-@ @ @ ng/mL vs @ @ ( P = @ ) , respectively-and at @:@ PM - @ @ vs @ @ ( P = @ ) , respectively .", "sentence_id": 13}
+{"abstract_id": "25607118", "label": "results", "text": "No consistent changes occurred in perfusion .", "sentence_id": 14}
+{"abstract_id": "25607118", "label": "results", "text": "The eVAS score decreased significantly compared with baseline in the placebo group but not in the active group .", "sentence_id": 15}
+{"abstract_id": "25607118", "label": "conclusions", "text": "Cortisol concentrations and eVAS scores showed significant differences between groups , which is consistent with the patches increasing energy production , warranting further testing .", "sentence_id": 16}
+{"abstract_id": "24968767", "label": "background", "text": "Due to the availability of new devices , the use of ventricular assist devices ( VADs ) in children has been increasing ; however , patient selection and optimal timing of device implantation in this population remains uncertain .", "sentence_id": 0}
+{"abstract_id": "24968767", "label": "methods", "text": "A retrospective review of the United Network for Organ Sharing dataset identified @,@ listings without mechanical circulatory support ( MCS ) for isolated pediatric heart transplant , @ to @ .", "sentence_id": 1}
+{"abstract_id": "24968767", "label": "methods", "text": "Patients were randomly divided into a derivation and validation cohort .", "sentence_id": 2}
+{"abstract_id": "24968767", "label": "methods", "text": "A multivariable logistic regression model predicting the likelihood of death or need for MCS within @ days was built using the derivation cohort and tested in the validation cohort .", "sentence_id": 3}
+{"abstract_id": "24968767", "label": "methods", "text": "A simplified score ( PedsMCS score ) was developed and evaluated for accuracy .", "sentence_id": 4}
+{"abstract_id": "24968767", "label": "results", "text": "The predictive model consisted of variables present at listing ( age , albumin level , creatinine clearance , serum bilirubin , mechanical ventilation , and inotropic support ) .", "sentence_id": 5}
+{"abstract_id": "24968767", "label": "results", "text": "It had good predictive ability ( C statistic @ ) within the validation cohort .", "sentence_id": 6}
+{"abstract_id": "24968767", "label": "results", "text": "The simplified PedsMCS score was also predictive ( C statistic @ ) and there was a strong correlation between predicted and expected outcomes ( r = @ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24968767", "label": "results", "text": "Patients with PedsMCS score @ or greater had a significantly higher risk of death or MCS within @ months ( @ % ) than those with low scores ( < @ ) ( @ % , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24968767", "label": "results", "text": "A single point increase in PedsMCS score was associated with a @ % increase in the risk of death or MCS with @ months ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24968767", "label": "conclusions", "text": "We have developed and validated a simplified score to predict the need for MCS based on risk factors present at listing .", "sentence_id": 10}
+{"abstract_id": "24968767", "label": "conclusions", "text": "This will provide more accurate prognostication in children awaiting heart transplant , and may improve patient selection .", "sentence_id": 11}
+{"abstract_id": "24958603", "label": "objective", "text": "Not all hypertensive patients respond well to ACE inhibition .", "sentence_id": 0}
+{"abstract_id": "24958603", "label": "objective", "text": "Here we determined whether renin-angiotensin system ( RAS ) phenotyping , i.e. , the measurement of renin or ACE , can predict the individual response to RAS blockade , either chronically ( enalapril vs. enalapril + candesartan ) or acutely ( enalaprilhydrochlorothiazide , HCT ) .", "sentence_id": 1}
+{"abstract_id": "24958603", "label": "results", "text": "Chronic enalapril + candesartan induced larger renin rises , but did not lower blood pressure ( BP ) more than enalapril .", "sentence_id": 2}
+{"abstract_id": "24958603", "label": "results", "text": "Similar observations were made for enalapril + HCT vs. enalapril when given acutely .", "sentence_id": 3}
+{"abstract_id": "24958603", "label": "results", "text": "Baseline renin predicted the peak changes in BP chronically , but not acutely .", "sentence_id": 4}
+{"abstract_id": "24958603", "label": "results", "text": "Baseline ACE levels had no predictive value .", "sentence_id": 5}
+{"abstract_id": "24958603", "label": "results", "text": "Yet , after acute drug intake , the degree of ACE inhibition , like renin , did correlate with BP .", "sentence_id": 6}
+{"abstract_id": "24958603", "label": "results", "text": "Only the relationship with renin remained significant after chronic RAS blockade .", "sentence_id": 7}
+{"abstract_id": "24958603", "label": "results", "text": "Thus , a high degree of ACE inhibition and a steep renin rise associate with larger acute responses to enalapril .", "sentence_id": 8}
+{"abstract_id": "24958603", "label": "results", "text": "However , variation was large , ranging > @mm Hg for a given degree of ACE inhibition or renin .", "sentence_id": 9}
+{"abstract_id": "24958603", "label": "results", "text": "The same was true for the relationships between renin and BP , and between baseline renin and the maximum reduction in BP in the chronic study .", "sentence_id": 10}
+{"abstract_id": "24958603", "label": "conclusions", "text": "Our data do not support that RAS phenotyping will help to predict the individual BP response to RAS blockade .", "sentence_id": 11}
+{"abstract_id": "24958603", "label": "conclusions", "text": "Notably , these conclusions were reached in a carefully characterized , homogenous population , and when taking into account the known fluctuations in renin that relate to gender , age , ethnicity , salt intake and diuretic treatment , it seems unlikely that a cut-off renin level can be defined that has predictive value .", "sentence_id": 12}
+{"abstract_id": "25282285", "label": "background", "text": "The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer .", "sentence_id": 0}
+{"abstract_id": "25282285", "label": "background", "text": "Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures , but these should be based on individuals ' probabilities of developing lung cancer .", "sentence_id": 1}
+{"abstract_id": "25282285", "label": "background", "text": "In this prespecified analysis , using data from the NELSON CT screening trial , we aimed to quantify how nodule diameter , volume , and volume doubling time affect the probability of developing lung cancer within @ years of a CT scan , and to propose and evaluate thresholds for management protocols .", "sentence_id": 2}
+{"abstract_id": "25282285", "label": "methods", "text": "Eligible participants in the NELSON trial were those aged @-@ years , who have smoked @ cigarettes or more per day for more than @ years , or ten cigarettes or more for more than @ years and were still smoking , or had stopped smoking less than @ years ago .", "sentence_id": 3}
+{"abstract_id": "25282285", "label": "methods", "text": "Participants were randomly assigned to low-dose CT screening at increasing intervals , or no screening .", "sentence_id": 4}
+{"abstract_id": "25282285", "label": "methods", "text": "We included all participants assigned to the screening group who had attended at least one round of screening , and whose results were available from the national cancer registry database .", "sentence_id": 5}
+{"abstract_id": "25282285", "label": "methods", "text": "We calculated lung cancer probabilities , stratified by nodule diameter , volume , and volume doubling time and did logistic regression analysis using diameter , volume , volume doubling time , and multinodularity as potential predictor variables .", "sentence_id": 6}
+{"abstract_id": "25282285", "label": "methods", "text": "We assessed management strategies based on nodule threshold characteristics for specificity and sensitivity , and compared them to the American College of Chest Physicians ( ACCP ) guidelines .", "sentence_id": 7}
+{"abstract_id": "25282285", "label": "methods", "text": "The NELSON trial is registered at www.trialregister.nl , number ISRCTN@ .", "sentence_id": 8}
+{"abstract_id": "25282285", "label": "results", "text": "Volume , volume doubling time , and volumetry-based diameter of @ non-calcified nodules detected by CT screening in @ participants in the screening group of NELSON were used to quantify lung cancer probability .", "sentence_id": 9}
+{"abstract_id": "25282285", "label": "results", "text": "Lung cancer probability was low in participants with a nodule volume of @ mm ( @ ) or smaller ( @ % -LSB- @ % CI @-@ -RSB- ) or maximum transverse diameter smaller than @ mm ( @ % -LSB- @-@ -RSB- ) , and not significantly different from participants without nodules ( @ % -LSB- @-@ -RSB- , p = @ and p = @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "25282285", "label": "results", "text": "Lung cancer probability was intermediate ( requiring follow-up CT ) if nodules had a volume of @-@ mm ( @ ) ( @ % -LSB- @ % CI @-@ -RSB- ) or a diameter @-@ mm ( @ % -LSB- @-@ -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "25282285", "label": "results", "text": "Volume doubling time further stratified the probabilities : @ % ( @ % CI @-@ ) for volume doubling times @ days or more , @ % ( @-@ ) for volume doubling times @-@ days , and @ % ( @-@ ) for volume doubling times of @ days or fewer .", "sentence_id": 12}
+{"abstract_id": "25282285", "label": "results", "text": "Lung cancer probability was high for participants with nodule volumes @ mm ( @ ) or bigger ( @ % -LSB- @ % CI @-@ -RSB- ) or diameters @ mm or bigger ( @ % -LSB- @-@ -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "25282285", "label": "results", "text": "The simulated ACCP management protocol yielded a sensitivity and specificity of @ % ( @ % CI @-@ ) , and @ % ( @-@ ) , respectively .", "sentence_id": 14}
+{"abstract_id": "25282285", "label": "results", "text": "A diameter-based protocol with volumetry-based nodule diameter yielded a higher sensitivity ( @ % -LSB- @ % CI @-@ -RSB- ) , and a higher specificity ( @ % -LSB- @-@ ) .", "sentence_id": 15}
+{"abstract_id": "25282285", "label": "results", "text": "A volume-based protocol ( with thresholds based on lung cancer probability ) yielded the same sensitivity as the ACCP protocol ( @ % -LSB- @ % CI @-@ -RSB- ) , and a higher specificity ( @ % -LSB- @-@ -RSB- ) .", "sentence_id": 16}
+{"abstract_id": "25282285", "label": "conclusions", "text": "Small nodules ( those with a volume < @ mm ( @ ) or diameter < @ mm ) are not predictive for lung cancer .", "sentence_id": 17}
+{"abstract_id": "25282285", "label": "conclusions", "text": "Immediate diagnostic evaluation is necessary for large nodules ( @ mm ( @ ) or @ mm ) .", "sentence_id": 18}
+{"abstract_id": "25282285", "label": "conclusions", "text": "Volume doubling time assessment is advocated only for intermediate-sized nodules ( with a volume ranging between @-@ mm ( @ ) or diameter of @-@ mm ) .", "sentence_id": 19}
+{"abstract_id": "25282285", "label": "conclusions", "text": "Nodule management protocols based on these thresholds performed better than the simulated ACCP nodule protocol .", "sentence_id": 20}
+{"abstract_id": "24249434", "label": "background", "text": "The aim of this research was to compare the pharmacodynamics of the combination of mitiglinide and sitagliptin to that of each agent alone in Korean patients with type @ diabetes mellitus ( T@DM ) .", "sentence_id": 0}
+{"abstract_id": "24249434", "label": "methods", "text": "Patients with T@DM received mitiglinide alone , sitagliptin alone , or both drugs together in randomized sequence .", "sentence_id": 1}
+{"abstract_id": "24249434", "label": "methods", "text": "A meal tolerance test ( MTT ) was conducted for each group , and plasma concentrations of glucose , insulin , C-peptide , glucagon , and intact glucagon-like peptide-@ , and dipeptidyl peptidase-@ activity were measured from @ h before breakfast through @ h after breakfast on day @ ( pretreatment ) and day @ ( posttreatment ) of each treatment period .", "sentence_id": 2}
+{"abstract_id": "24249434", "label": "methods", "text": "Integrated values of these pharmacodynamic variables were analyzed for changes from pretreatment to posttreatment and for differences between the three treatment groups .", "sentence_id": 3}
+{"abstract_id": "24249434", "label": "results", "text": "Twenty-six patients with glycated hemoglobin A@c level of @ % @ % , fasting plasma glucose concentration of @ @ mg/dL , postprandial plasma glucose ( PPG ) concentration of @ @ mg/dL @ h after the MTT , and diabetes duration of @ @ years ( mean SD ) were included in the study .", "sentence_id": 4}
+{"abstract_id": "24249434", "label": "results", "text": "Compared with mitiglinide or sitagliptin alone , the combination treatment lowered PPG additively ( P < @ vs. mitiglinide or sitagliptin alone ) and the insulin secretory response ( P = @ vs. mitiglinide or sitagliptin alone ) .", "sentence_id": 5}
+{"abstract_id": "24249434", "label": "results", "text": "The integrated insulin concentrations changed significantly from before to after treatment ( P < @ ) , but the change did not differ between the combination and mitiglinide groups .", "sentence_id": 6}
+{"abstract_id": "24249434", "label": "results", "text": "The insulinogenic index increased significantly after the combination treatment ( P < @ vs. mitiglinide or sitagliptin alone ) .", "sentence_id": 7}
+{"abstract_id": "24249434", "label": "results", "text": "The combination of mitiglinide and sitagliptin was generally well tolerated , with no hypoglycemic events .", "sentence_id": 8}
+{"abstract_id": "24249434", "label": "conclusions", "text": "The combination of mitiglinide and sitagliptin did not trigger hypoglycemia and controlled postprandial glucose excursion more effectively compared with either drug alone .", "sentence_id": 9}
+{"abstract_id": "24520741", "label": "background", "text": "Alterations of the parameters of heart rate variability , phenomenon associated with autonomic nervous system balance , have been shown as a possibly very important factor for monitoring of cardiocirculatory system in the perioperative period .", "sentence_id": 0}
+{"abstract_id": "24520741", "label": "background", "text": "Periinduction period of general anaesthesia is very important with significant changes of haemodynamics what could be reflected in the changes of the parameter of heart rate variability .", "sentence_id": 1}
+{"abstract_id": "24520741", "label": "methods", "text": "A hundred patients of ASA I and ASA II status who were scheduled for elective abdominal surgical procedures of moderate stress response , were randomly assigned to group I and group II , who were administered propofol or thiopentone as induction anaesthetic , respectively .", "sentence_id": 2}
+{"abstract_id": "24520741", "label": "methods", "text": "Monitoring during periinduction period included of monitoring of mean blood pressure ( noninvasively ) , heart rate , pulseoxymetry and recording of electrocardiogram by holter ECG recorder for further analysis of heart rate variability , in four time segments in periinduction period : Tp , T@ , T@ , T@ .", "sentence_id": 3}
+{"abstract_id": "24520741", "label": "methods", "text": "Data were presented as mean values of absolute values of the power of the total spectrum of heart rate variability , mean values of the spectrum of low frequency band ( LF ) , mean values of the high frequency range , and the ratio LF/HF .", "sentence_id": 4}
+{"abstract_id": "24520741", "label": "results", "text": "Analysis of the values of hemodynamic parameters has shown decrease of mean arterial blood pressure after induction of anaesthesia with intravenous anesthetics thiopental or propofol , with simultaneous changes of heart rate in the four time segments in periinduction period , without statistically significant changes between the groups .", "sentence_id": 5}
+{"abstract_id": "24520741", "label": "results", "text": "Analysis of the values of parameters of heart rate variability measured in the frequency domain has shown changes of mean values of the absolute values of total power spectrum , mean values of the power of low frequency spectrum and mean values of the power of high power spectrum with reduction of the values of total power spectrum , the power of low frequency spectrum and the power of high frequency spectrum , most pronounced just after induction of anaesthesia with slight increase of the values of total power spectrum and individual components of the spectrum of heart rate variability in the later postinduction period , without statistically significant differences between the groups .", "sentence_id": 6}
+{"abstract_id": "24520741", "label": "conclusions", "text": "The results have shown that in the groups of patients who underwent induction of general anaesthesia with propofol or thiopentone , there have been reductions of the total spectral power and the power of the spectrum of low frequency components and high frequency components with variations in the relationship between the components in the different periods of periinduction time .", "sentence_id": 7}
+{"abstract_id": "24986722", "label": "background", "text": "In a task-environment where visibility has deteriorated , individuals rely heavily on tactile performance ( perception and manipulation ) to complete complex tasks .", "sentence_id": 0}
+{"abstract_id": "24986722", "label": "background", "text": "When this happens under hyperbaric conditions , factors like nitrogen narcosis could influence a person 's ability to successfully complete such tasks .", "sentence_id": 1}
+{"abstract_id": "24986722", "label": "objective", "text": "To examine the effect of nitrogen narcosis on a complex neuropsychological task measuring tactile performance at a pressure of @ kPa ( @ atm abs ) , in the absence of visual access to the task .", "sentence_id": 2}
+{"abstract_id": "24986722", "label": "methods", "text": "In a prospective cross-over study , @ commercial divers were tested in a dry chamber at @ kPa and @ kPa .", "sentence_id": 3}
+{"abstract_id": "24986722", "label": "methods", "text": "They completed the Tupperware Neuropsychological Task ( TNT ) of tactile performance without visual access to the task , and completed questionnaires to provide psychological and biographical data , which included trait anxiety and transient mood states , as well as formal qualifications and technical proficiency .", "sentence_id": 4}
+{"abstract_id": "24986722", "label": "results", "text": "A significant decrement ( @ % , P < @ ) in performance on the TNT at depth was found , irrespective of the sequence of testing .", "sentence_id": 5}
+{"abstract_id": "24986722", "label": "results", "text": "Generally , neither the psychological nor biographical variables showed any significant effect on tactile performance .", "sentence_id": 6}
+{"abstract_id": "24986722", "label": "results", "text": "Tactile performance on the surface was a good indicator of performance at depth .", "sentence_id": 7}
+{"abstract_id": "24986722", "label": "conclusions", "text": "These findings have practical implications for professional diving where conditions of low visibility during deeper diving occur .", "sentence_id": 8}
+{"abstract_id": "24986722", "label": "conclusions", "text": "Recommendations are made towards managing potential impairments in tactile performance , such as pre-dive practical learning ( ` rehearsal ' ) as an aid to successful completion of tasks .", "sentence_id": 9}
+{"abstract_id": "24928359", "label": "objective", "text": "To compare the results for treatment of basal thumb osteoarthritis with and without the use of a bone tunnel at the base of the first metacarpal .", "sentence_id": 0}
+{"abstract_id": "24928359", "label": "methods", "text": "Women aged @ years or older with stage IV osteoarthritis were randomized to @ of @ treatments .", "sentence_id": 1}
+{"abstract_id": "24928359", "label": "methods", "text": "Patients were evaluated preoperatively and postoperatively at @ and @ months by assessing pain , outcome function measures , range of motion , strength , time to return to work or activities , satisfaction with the results , and complication rate .", "sentence_id": 2}
+{"abstract_id": "24928359", "label": "results", "text": "A total of @ patients were enrolled in this study .", "sentence_id": 3}
+{"abstract_id": "24928359", "label": "results", "text": "Three months after surgery , Patient-Rated Wrist and Hand Evaluation pain and total scores were significantly improved in the bone tunnel group compared with the tunnel-free group .", "sentence_id": 4}
+{"abstract_id": "24928359", "label": "results", "text": "At @ months , however , we found no significant differences for all outcome scores between groups .", "sentence_id": 5}
+{"abstract_id": "24928359", "label": "results", "text": "In addition , we observed no significant differences between groups in strength , duration to return to work or activities , patient satisfaction , and complication rates .", "sentence_id": 6}
+{"abstract_id": "24928359", "label": "conclusions", "text": "After the bone tunnel technique , patients have better function and less pain @ months after surgery than do those in the non-bone tunnel group , which indicates faster recovery .", "sentence_id": 7}
+{"abstract_id": "24928359", "label": "conclusions", "text": "However , @ months after surgery , the functional outcome was similar .", "sentence_id": 8}
+{"abstract_id": "24928359", "label": "conclusions", "text": "Because of faster recovery , we prefer the bone tunnel technique in the treatment of stage IV osteoarthritis .", "sentence_id": 9}
+{"abstract_id": "25329653", "label": "background", "text": "Within the field of oncology , increasing access to high quality care has been identified as a priority to reduce cancer disparities .", "sentence_id": 0}
+{"abstract_id": "25329653", "label": "background", "text": "Previous research reveals that the facilities where patients receive their cancer care have implications for cancer outcomes .", "sentence_id": 1}
+{"abstract_id": "25329653", "label": "background", "text": "However , there is little understanding of how patients decide where to seek cancer care .", "sentence_id": 2}
+{"abstract_id": "25329653", "label": "background", "text": "This study examined the factors that shape patients ' pathways to seek their cancer care at a National Cancer Institute-designated comprehensive cancer center ( NCI-CCC ) , and differences in these factors by race , income and education .", "sentence_id": 3}
+{"abstract_id": "25329653", "label": "methods", "text": "In-depth interviews and survey questionnaires were administered to a random sample of @ patients at one NCI-CCC in the Northeast US .", "sentence_id": 4}
+{"abstract_id": "25329653", "label": "methods", "text": "In-depth interview data was first analyzed qualitatively to identify themes and patterns in patients ' pathways to receive their cancer care at an NCI-CCC .", "sentence_id": 5}
+{"abstract_id": "25329653", "label": "methods", "text": "Logistic Regression was used to examine if these pathways varied by patient race , income , and education .", "sentence_id": 6}
+{"abstract_id": "25329653", "label": "results", "text": "Two themes emerged : following the recommendation of a physician and following advice from social network members .", "sentence_id": 7}
+{"abstract_id": "25329653", "label": "results", "text": "Quantitative data analysis shows that patient pathways to care at an NCI-CCC varied by education and income .", "sentence_id": 8}
+{"abstract_id": "25329653", "label": "results", "text": "Patients with lower income and education most commonly sought their cancer care at an NCI-CCC due to the recommendation of a physician .", "sentence_id": 9}
+{"abstract_id": "25329653", "label": "results", "text": "Patients with higher income and education most commonly cited referral by a specialist physician or the advice of a social network member .", "sentence_id": 10}
+{"abstract_id": "25329653", "label": "results", "text": "There were no statistically significant differences in pathways to care by race .", "sentence_id": 11}
+{"abstract_id": "25329653", "label": "conclusions", "text": "Our findings show that most patients relied on physician recommendations or advice from a social network member in deciding to seek their cancer care at an NCI-CCC .", "sentence_id": 12}
+{"abstract_id": "25329653", "label": "conclusions", "text": "Due to the role of physicians in shaping patients ' pathways to the NCI-CCC , initiatives that strengthen partnerships between NCI-CCCs and community physicians who serve underserved communities may improve access to NCI-CCCs .", "sentence_id": 13}
+{"abstract_id": "25571684", "label": "objective", "text": "The aim of the present study is to determine the possible effect of Bifidobacterium bifidum DN-@ @ on dental plaque of children .", "sentence_id": 0}
+{"abstract_id": "25571684", "label": "methods", "text": "@ children ( @ F and @ M ) , between the ages of @-@ , participated in the present study .", "sentence_id": 1}
+{"abstract_id": "25571684", "label": "methods", "text": "The study had a double blind , randomized crossover design and the experimental period consisted of four consecutive time periods .", "sentence_id": 2}
+{"abstract_id": "25571684", "label": "methods", "text": "During periods @ and @ ( @ weeks each ) , children consumed @ g probiotic fruit yogurt ( Bifidobacterium DN-@ @ ( @ x @ ( @ ) cfu/g ) ) , or a placebo fruit yogurt per day .", "sentence_id": 3}
+{"abstract_id": "25571684", "label": "methods", "text": "Available supragingival plaque ( @ h later ) was collected from teeth @ , @ , @ and @ at baseline and at the end of periods @ and @ .", "sentence_id": 4}
+{"abstract_id": "25571684", "label": "methods", "text": "The counts of dental plaque mutans streptococci ( MS ) were evaluated using Dentocult SM ( Strep Mutans ) .", "sentence_id": 5}
+{"abstract_id": "25571684", "label": "results", "text": "Changes of pre - and post-treatment levels of dental plaque MS were recorded for four consecutive sampling sites .", "sentence_id": 6}
+{"abstract_id": "25571684", "label": "results", "text": "There were no statistically differences between transition scores of test and placebo groups regarding different dental plaque sampling sites ( p > @ ) ( unpaired t-test ) .", "sentence_id": 7}
+{"abstract_id": "25571684", "label": "conclusions", "text": "Within the limitations of the present study , Bifidobacterium bifidum DN-@ @ has no effect on dental plaque MS levels in children .", "sentence_id": 8}
+{"abstract_id": "24957977", "label": "objective", "text": "Accumulating evidence indicates that plastic changes can be maladaptive in nature , resulting in movement and neurological disorders .", "sentence_id": 0}
+{"abstract_id": "24957977", "label": "objective", "text": "The aim of this study was to further the understanding of these neurophysiological changes in sensorimotor integration ( SMI ) using somatosensory evoked potentials ( SEPs ) and concurrent performance changes following a repetitive typing task .", "sentence_id": 1}
+{"abstract_id": "24957977", "label": "methods", "text": "SEPs were recorded following median nerve stimulation at the wrist and performed pre and post intervention .", "sentence_id": 2}
+{"abstract_id": "24957977", "label": "methods", "text": "@ participants were randomly assigned to either an intervention group which performed a @min repetitive typing task or a control group which participated in a @min period of mental recitation .", "sentence_id": 3}
+{"abstract_id": "24957977", "label": "results", "text": "The P@-N@ amplitude increased by @ % , compared to only @ % increase following the control .", "sentence_id": 4}
+{"abstract_id": "24957977", "label": "results", "text": "The P@-N@ SEP peak amplitude increased on average @ % following the motor training , compared to only @ % following the control .", "sentence_id": 5}
+{"abstract_id": "24957977", "label": "results", "text": "Significant improvement in reaction time when comparing performance of the motor task for the intervention group was observed .", "sentence_id": 6}
+{"abstract_id": "24957977", "label": "conclusions", "text": "The N@ increase supports the involvement of cerebellar connections and the N@ increase provides further support for changes in SMI following motor learning .", "sentence_id": 7}
+{"abstract_id": "24957977", "label": "conclusions", "text": "Combining motor training tasks with electrophysiological techniques gives insight into the mechanisms of disordered SMI and whether the changes are adaptive or maladaptive .", "sentence_id": 8}
+{"abstract_id": "25449510", "label": "background", "text": "Electrocardiographic ( ECG ) identification of prior myocardial infarction ( MI ) during right ventricular ( RV ) pacing is of clinical importance .", "sentence_id": 0}
+{"abstract_id": "25449510", "label": "background", "text": "Proposed ECG criteria have been evaluated only during apical pacing .", "sentence_id": 1}
+{"abstract_id": "25449510", "label": "background", "text": "We evaluated the effect of pacing site on the predictive performance of ECG signs of prior MI .", "sentence_id": 2}
+{"abstract_id": "25449510", "label": "methods", "text": "The present study is a secondary analysis of a prospective , multicenter study which randomized recipients of an implantable cardioverter defibrillator to an apical versus septal RV lead positioning .", "sentence_id": 3}
+{"abstract_id": "25449510", "label": "methods", "text": "ECGs of patients with or without prior MI were analyzed for the presence of the following criteria : Cabrera sign , Chapman sign , QR pattern in leads I , aVL , V@ or V@ , QR in inferior leads and notching in the descending slope of the QRS complex in inferior leads .", "sentence_id": 4}
+{"abstract_id": "25449510", "label": "results", "text": "The MI group included @ patients ( @ % apically paced ) , while @ patients had no prior MI ( @ % apically paced ) .", "sentence_id": 5}
+{"abstract_id": "25449510", "label": "results", "text": "In the total population , the Cabrera sign presented the highest specificity ( @ % ) and diagnostic accuracy ( @ % ) , with a sensitivity of @ % .", "sentence_id": 6}
+{"abstract_id": "25449510", "label": "results", "text": "The Cabrera sign was the only significant predictor of a prior MI -LSB- OR = @ , ( @ % CI :@ -@ ) , p < @ -RSB- , among all ECG markers .", "sentence_id": 7}
+{"abstract_id": "25449510", "label": "results", "text": "Pacing site did not significantly influence the sensitivity and specificity of the Cabrera sign for detection of prior MI .", "sentence_id": 8}
+{"abstract_id": "25449510", "label": "conclusions", "text": "In our study , the Cabrera sign was the only ECG marker that predicted the presence of prior MI during ventricular paced rhythm .", "sentence_id": 9}
+{"abstract_id": "25449510", "label": "conclusions", "text": "Septal RV lead positioning did not affect the predictive performance of the Cabrera sign .", "sentence_id": 10}
+{"abstract_id": "24684104", "label": "objective", "text": "To observe the protective effect of transcutaneous electrical acupoint stimulation ( TEAS ) on cerebral tissue in elderly hip replacement operation patients during general anesthesia under controlled hypotension .", "sentence_id": 0}
+{"abstract_id": "24684104", "label": "methods", "text": "Forty hip replacement operation patients were randomly divided into general anesthesia ( GA ) control group and TEAS + GA group ( n = @ in each group ) .", "sentence_id": 1}
+{"abstract_id": "24684104", "label": "methods", "text": "Patients of the two groups during operation were treated with controlled hypotension for reducing blood loss .", "sentence_id": 2}
+{"abstract_id": "24684104", "label": "methods", "text": "TEAS ( @ Hz/@ Hz , @-@ mA ) was applied to bilateral Yuyao ( EX-HN @ ) and Fengchi ( GB @ ) and began @ min before GA. .", "sentence_id": 3}
+{"abstract_id": "24684104", "label": "methods", "text": "General anesthesia was performed by intravenous injection of Midazolam , Diprivan , Fentanyl and Cis-atracurium , sevoflurane-inhaling , Remifentanil , etc. , and the patient 's mean arterial pressure was maintained to be about @ % of the normal level ( controlled hypotension ) by using venous administration of Remifentanil about @ min after the operation .", "sentence_id": 4}
+{"abstract_id": "24684104", "label": "methods", "text": "GEM Premier @ blood gas analyzer was used to analyze levels of the arterial oxygen ( CaO@ ) , internal jugular venous oxygen ( CjvO@ ) , arterio-venous oxygen content difference ( Da-jvO@ ) and cerebral oxygen ( CERO@ ) uptake rates of blood samples before controlled hypotension ( T@ ) , @ min after controlled hypotension ( T ) .", "sentence_id": 5}
+{"abstract_id": "24684104", "label": "methods", "text": "@ min after controlled hypotension ( T@ ) and @ min after the end of controlled hypotension ( T@ ) .", "sentence_id": 6}
+{"abstract_id": "24684104", "label": "results", "text": "Self-comparison of each group showed that in comparison with pre-controlled hypotension , CjvO@ levels at the time-points of T , T@ and T@ were significantly increased in both GA control and TEAS+GA groups ( P < @ ) , while Da-jvO@ and CERO@ uptake rate levels at the time-points of T , .", "sentence_id": 7}
+{"abstract_id": "24684104", "label": "results", "text": "T@ and T@ in these two groups were significantly decreased ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24684104", "label": "results", "text": "Comparison between two groups showed that CivO@ levels at the time-points of T@ and T@ were significantly higher in the TEAS + GA group than in the GA control group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24684104", "label": "results", "text": "while Da-jvO@ and CERO@ uptake rate levels at the time-point of T@ were obviously lower in the TEAS + GA group than in the GA control group ( P < @ ) , suggesting a reduction of cerebral oxygen consumption after TEAS .", "sentence_id": 10}
+{"abstract_id": "24684104", "label": "results", "text": "No significant differences were found between these two groups in blood CjvO@ , Da-jvO@ and CERO@ uptake rate levels at the time-points of T@ and T@ ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "24684104", "label": "conclusions", "text": "TEAS can reduce cerebral oxygen uptake rate in elderly patients undergoing hip replacement during controlled hypotension , suggesting a protective effect of TEAS on patient 's cerebral tissue .", "sentence_id": 12}
+{"abstract_id": "25081652", "label": "background", "text": "Home mechanical ventilation ( HMV ) in the Netherlands is normally initiated in hospital , but this is expensive and often a burden for the patient .", "sentence_id": 0}
+{"abstract_id": "25081652", "label": "background", "text": "In this randomised controlled study we investigated whether initiation of HMV at home in patients with chronic respiratory failure is non-inferior to an in hospital based setting .", "sentence_id": 1}
+{"abstract_id": "25081652", "label": "methods", "text": "Seventy-seven patients were included , of which @ patients started HMV at home .", "sentence_id": 2}
+{"abstract_id": "25081652", "label": "methods", "text": "All patients were diagnosed with chronic respiratory failure due to a neuromuscular or thoracic cage disease .", "sentence_id": 3}
+{"abstract_id": "25081652", "label": "methods", "text": "Primary outcome was the arterial carbon dioxide ( PaCO@ ) while quality of life and costs were secondary outcomes .", "sentence_id": 4}
+{"abstract_id": "25081652", "label": "methods", "text": "Telemonitoring was used in the home group to provide therapeutic information , for example ; transcutaneous carbon dioxide , oxygen saturation and ventilator information , to the caregivers .", "sentence_id": 5}
+{"abstract_id": "25081652", "label": "methods", "text": "Follow-up was six months .", "sentence_id": 6}
+{"abstract_id": "25081652", "label": "results", "text": "PaCO@ , improved by @ ( SE@ @ ) kPa in the hospital group and by @ ( @ ) in the home group , both improvements being significant and the latter clearly not inferior .", "sentence_id": 7}
+{"abstract_id": "25081652", "label": "results", "text": "There were also significant improvements in quality of life in both groups , again not being inferior with home treatment .", "sentence_id": 8}
+{"abstract_id": "25081652", "label": "conclusions", "text": "This study is the first to show that initiation of HMV at home in a selective group of patients with chronic respiratory failure is as effective for gas exchange and quality of life as hospital initiation .", "sentence_id": 9}
+{"abstract_id": "25081652", "label": "conclusions", "text": "In addition we found that it is safe , technically feasible and that more than @ per patient can be saved compared to our standard care .", "sentence_id": 10}
+{"abstract_id": "24316711", "label": "objective", "text": "To compare the three non-steroidal anti-inflammatory agents ( NSAIDs ) Diclofenac potassium , Etodolac and Naproxen sodium in relation to pain , swelling and trismus following impacted third molar surgery .", "sentence_id": 0}
+{"abstract_id": "24316711", "label": "methods", "text": "The study was a randomized and a double-blinded study which included @ healthy young individuals with impacted third molars and bone retention .", "sentence_id": 1}
+{"abstract_id": "24316711", "label": "methods", "text": "Patients were randomly assigned to @ groups ( n : @ ) to which Diclofenac potassium , Naproxen sodium and Etodolac were administered orally an hour before the operation .", "sentence_id": 2}
+{"abstract_id": "24316711", "label": "methods", "text": "Impacted third molars were surgically extracted with local anaesthesia .", "sentence_id": 3}
+{"abstract_id": "24316711", "label": "methods", "text": "Visual analog scales ( VAS ) were used to assess the pain in the @th , @th hours and on the @st , @nd , @rd , @th , and @th days postoperatively .", "sentence_id": 4}
+{"abstract_id": "24316711", "label": "methods", "text": "Swelling was evaluated using ultrasound ( US ) and mouth opening ( trismus ) was measured with a composing stick pre and post operatively on the @nd and @th days respectively .", "sentence_id": 5}
+{"abstract_id": "24316711", "label": "results", "text": "Regarding pain alleviation , Diclofenac potassium was better than Naproxen sodium and Naproxen sodium was better than Etodolac but these differences were not statistically significant .", "sentence_id": 6}
+{"abstract_id": "24316711", "label": "results", "text": "US measurements showed that the swelling on postoperative @nd day was significantly lowest with Diclofenac potassium as compared to others ( p = @ ) while Naproxen sodium and Etodolac acted similarly ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24316711", "label": "results", "text": "No difference was noted regarding trismus in any of the groups .", "sentence_id": 8}
+{"abstract_id": "24316711", "label": "conclusions", "text": "NSAIDs ( Diclofenac , Naproxen and Etodolac ) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but Diclofenac potassium surpasses others in reduction of swelling .", "sentence_id": 9}
+{"abstract_id": "24432626", "label": "objective", "text": "To observe the efficacy of the combination of Qilin Pills and levofloxacin in the treatment of asthenospermia accompanied with accessory sex gland infection .", "sentence_id": 0}
+{"abstract_id": "24432626", "label": "methods", "text": "We randomly assigned @ asthenospermia patients with accessory sex gland infection to groups @ and @ of equal number , the former treated with Qilin Pills + levofloxacin , and the latter with levofloxacin only .", "sentence_id": 1}
+{"abstract_id": "24432626", "label": "methods", "text": "Qilin Pills were administered at the dose of @ g tid for @ days , and levofloxacin at the dose of @ g qd for @ days .", "sentence_id": 2}
+{"abstract_id": "24432626", "label": "methods", "text": "We obtained semen parameters , including the percentage of progressively motile sperm and peroxidase-positive white blood cell ( WBC ) count , before and after medication , and compared the clinical effects between the two groups .", "sentence_id": 3}
+{"abstract_id": "24432626", "label": "results", "text": "All the patients accomplished the clinical trial .", "sentence_id": 4}
+{"abstract_id": "24432626", "label": "results", "text": "The therapeutic effectiveness rates in improving progressive sperm motility were @ % in group @ and @ % in group @ , with statistically significant differences between the two groups ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24432626", "label": "results", "text": "As for the peroxidase-positive WBC count in semen , the effectiveness rates were @ % and @ % , respectively , with no significant differences between the two groups ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24432626", "label": "conclusions", "text": "For the treatment of asthenospermia accompanied with accessory sex gland infection , Qilin Pills combined with levofloxacin is evidently better than levofloxacin alone in improving sperm motility , and it has no obvious adverse effects .", "sentence_id": 7}
+{"abstract_id": "25741969", "label": "objective", "text": "To investigate the association between feeding patterns and HIV-free survival in children born to HIV-infected mothers and to clarify whether antiretroviral ( ARV ) prophylaxis modifies the association .", "sentence_id": 0}
+{"abstract_id": "25741969", "label": "methods", "text": "From June @ to August @ , HIV-infected pregnant women were counseled regarding infant feeding options , and randomly assigned to triple-ARV prophylaxis ( triple ARV ) until breastfeeding cessation ( BFC ) before age @ months or antenatal zidovudine with single-dose nevirapine ( short-course ARV ) .", "sentence_id": 1}
+{"abstract_id": "25741969", "label": "methods", "text": "Eighteen-month HIV-free survival of infants HIV-negative at @ weeks of age was assessed by feeding patterns ( replacement feeding from birth , BFC < @ months , BFC @ months ) .", "sentence_id": 2}
+{"abstract_id": "25741969", "label": "results", "text": "Of the @ infants alive and HIV-negative at @ weeks , @ acquired infection and @ died by @ months .", "sentence_id": 3}
+{"abstract_id": "25741969", "label": "results", "text": "Overall HIV-free survival at @ months was @ -LSB- @ % confidence interval ( CI ) : @-@ @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "25741969", "label": "results", "text": "In the short-course ARV arm , HIV-free survival ( @ ; CI : @-@ @ ) did not differ by feeding patterns .", "sentence_id": 5}
+{"abstract_id": "25741969", "label": "results", "text": "In the triple ARV arm , overall HIV-free survival was @ ( CI : @-@ @ ) and BFC < @ months was associated with lower HIV-free survival than BFC @ months ( adjusted hazard ratio : @ ; CI : @-@ @ ) and replacement feeding ( adjusted hazard ratio : @ ; CI : @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "25741969", "label": "results", "text": "In the triple ARV arm , @ of @ transmissions occurred after reported BFC ( and @ of @ in the short-course arm ) , indicating that some women continued breastfeeding after interruption of ARV prophylaxis .", "sentence_id": 7}
+{"abstract_id": "25741969", "label": "conclusions", "text": "In resource-constrained settings , early weaning has previously been associated with higher infant mortality .", "sentence_id": 8}
+{"abstract_id": "25741969", "label": "conclusions", "text": "We show that , even with maternal triple-ARV prophylaxis during breastfeeding , early weaning remains associated with lower HIV-free survival , driven in particular by increased mortality .", "sentence_id": 9}
+{"abstract_id": "25108545", "label": "background", "text": "Fluticasone furoate ( FF ) is a novel , once-daily inhaled corticosteroid ( ICS ) that has been shown to improve lung function vs. placebo in asthma patients .", "sentence_id": 0}
+{"abstract_id": "25108545", "label": "background", "text": "This study evaluated the efficacy and safety of FF @ mcg compared with placebo in asthma patients uncontrolled by non-ICS therapy .", "sentence_id": 1}
+{"abstract_id": "25108545", "label": "methods", "text": "This @-week , multicentre , randomized , double-blind , placebo-controlled , parallel-group , phase III study randomized @ patients ( aged @ years ) to once-daily FF @ mcg administered via the ELLIPTAa dry powder inhaler or placebo .", "sentence_id": 2}
+{"abstract_id": "25108545", "label": "methods", "text": "The primary endpoint was change from baseline in pre-dose evening trough forced expiratory volume in one second ( FEV@ ) .", "sentence_id": 3}
+{"abstract_id": "25108545", "label": "methods", "text": "Secondary endpoints were change from baseline in percentage of rescue-free @-h periods ( powered ) , evening and morning peak expiratory flow , symptom-free @-h periods and withdrawals due to lack of efficacy .", "sentence_id": 4}
+{"abstract_id": "25108545", "label": "methods", "text": "Other endpoints included Asthma Control Test , Asthma Quality of Life Questionnaire and ELLIPTA ease of use questions .", "sentence_id": 5}
+{"abstract_id": "25108545", "label": "methods", "text": "Safety was assessed throughout the study .", "sentence_id": 6}
+{"abstract_id": "25108545", "label": "results", "text": "There was a significant difference in evening trough FEV@ between FF @ mcg and placebo ( treatment difference : @ mL ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25108545", "label": "results", "text": "There was also a significant difference in rescue-free @-h periods ( @ % ; p = @ ) vs. placebo .", "sentence_id": 8}
+{"abstract_id": "25108545", "label": "results", "text": "There were numerically greater improvements with FF vs. placebo for all remaining secondary endpoints .", "sentence_id": 9}
+{"abstract_id": "25108545", "label": "results", "text": "The incidence of adverse events was lower with FF ( @ % ) than with placebo ( @ % ) ; few were treatment-related ( FF @ mcg : n = @ , < @ % ; placebo : n = @ , @ % ) .", "sentence_id": 10}
+{"abstract_id": "25108545", "label": "conclusions", "text": "FF @ mcg once daily significantly improved FEV@ and percentage of rescue-free @-h periods experienced over @ weeks vs. placebo , and was well tolerated .", "sentence_id": 11}
+{"abstract_id": "24921611", "label": "objective", "text": "The aim of this study was to compare the effects of plyometric training versus basketball technique training on improving neuro-muscular performance .", "sentence_id": 0}
+{"abstract_id": "24921611", "label": "methods", "text": "Thirty-six ( age @ years , body height @ cm , body weight @ kg , BMI @ kgm-@ ) basketball players girls were randomly allocated to @ groups : Basketball Plyometric Training ( BPT , N. = @ ) and Basketball Technique Training ( BTT , N. = @ ) .", "sentence_id": 1}
+{"abstract_id": "24921611", "label": "methods", "text": "The players were tested by two specific tests : counter movement jump ( CMJ ) and squat jump ( SJ ) before and after @ training weeks .", "sentence_id": 2}
+{"abstract_id": "24921611", "label": "results", "text": "The jump height , as dependent variable , showed a different trend as an effect of the different training protocols , in contrast with the current knowledge .", "sentence_id": 3}
+{"abstract_id": "24921611", "label": "results", "text": "Manova did not show significant interactions between the two groups for the height of jumps , while significant differences were found for interaction time training ( P < @ ) and for main effect time ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24921611", "label": "results", "text": "After training , the BPT group increased significantly CMJ performance by @ % ( P < @ ) , whereas the BTT group increased by @ % .", "sentence_id": 5}
+{"abstract_id": "24921611", "label": "results", "text": "Likewise , the BPT group demonstrated a significant greater improvement of jump height than BTT group ( an increase of @ % vs. @ % , P < @ ; respectively ) .", "sentence_id": 6}
+{"abstract_id": "24921611", "label": "conclusions", "text": "These results suggest that both training protocols proposed in this study improved vertical jump performance .", "sentence_id": 7}
+{"abstract_id": "24921611", "label": "conclusions", "text": "However , a combination of the two protocols , plyometric training and sport-specific-exercises , could be useful to optimize performance by an easy transition from controlled a-specific to sport-specific performance requirements .", "sentence_id": 8}
+{"abstract_id": "24921611", "label": "conclusions", "text": "In conclusion , BPT is a safe and effective method of achieving a favourable neuro-muscular performance than BTT in female basketball players .", "sentence_id": 9}
+{"abstract_id": "25377415", "label": "objective", "text": "The objective of this study was to determine the feasibility of telementored instruction in bedside ultrasonography ( US ) using Google Glass .", "sentence_id": 0}
+{"abstract_id": "25377415", "label": "objective", "text": "The authors sought to examine whether first-time US users could obtain adequate parasternal long axis ( PSLA ) views to approximate ejection fraction ( EF ) using Google Glass telementoring .", "sentence_id": 1}
+{"abstract_id": "25377415", "label": "methods", "text": "This was a prospective , randomized , single-blinded study .", "sentence_id": 2}
+{"abstract_id": "25377415", "label": "methods", "text": "Eighteen second-year medical students were randomized into three groups and tasked with obtaining PSLA cardiac imaging .", "sentence_id": 3}
+{"abstract_id": "25377415", "label": "methods", "text": "Group A received real-time telementored education through Google Glass via Google Hangout from a remotely located expert .", "sentence_id": 4}
+{"abstract_id": "25377415", "label": "methods", "text": "Group B received bedside education from the same expert .", "sentence_id": 5}
+{"abstract_id": "25377415", "label": "methods", "text": "Group C represented the control and received no instruction .", "sentence_id": 6}
+{"abstract_id": "25377415", "label": "methods", "text": "Each subject was given @ minutes to obtain a best PSLA cardiac imaging using a portable GE Vscan .", "sentence_id": 7}
+{"abstract_id": "25377415", "label": "methods", "text": "Image clips obtained by each subject were stored .", "sentence_id": 8}
+{"abstract_id": "25377415", "label": "methods", "text": "A second expert , blinded to instructional mode , evaluated images for adequacy and assigned an image quality rating on a @ to @ scale .", "sentence_id": 9}
+{"abstract_id": "25377415", "label": "results", "text": "Group A was able to obtain adequate images six out of six times ( @ % ) with a median image quality rating of @ ( interquartile range -LSB- IQR -RSB- = @ to @ ) out of @ .", "sentence_id": 10}
+{"abstract_id": "25377415", "label": "results", "text": "Group B was also able to obtain adequate views six out of six times ( @ % ) , with a median image quality rating of @ ( IQR = @ to @ ) .", "sentence_id": 11}
+{"abstract_id": "25377415", "label": "results", "text": "Group C was able to obtain adequate views one out of six times ( @ % ) , with a median image quality of @ ( IQR = @ to @ ) .", "sentence_id": 12}
+{"abstract_id": "25377415", "label": "results", "text": "There were no statistically significant differences between Group A and Group B in the achievement of adequate images for E-point septal separation measurement or in image quality .", "sentence_id": 13}
+{"abstract_id": "25377415", "label": "conclusions", "text": "In this pilot/feasibility study , novice US users were able to obtain adequate imaging to determine a healthy patient 's EF through telementored education using Google Glass .", "sentence_id": 14}
+{"abstract_id": "25377415", "label": "conclusions", "text": "These preliminary data suggest telementoring as an adequate means of medical education in bedside US .", "sentence_id": 15}
+{"abstract_id": "25377415", "label": "conclusions", "text": "This conclusion will need to be validated with larger , more powerful studies including evaluation of pathologic findings and varying body habitus among models .", "sentence_id": 16}
+{"abstract_id": "24755132", "label": "objective", "text": "To compare the pharmacokinetic profiles and to evaluate the bioequivalence of two commercial amoxicillin suspension formulations ( @ mg/@ mL AMOXIL , reference formulation and AMOXI-PED , test formulation ) in healthy Brazilian volunteers .", "sentence_id": 0}
+{"abstract_id": "24755132", "label": "methods", "text": "Under fasting condition , @ volunteers ( @ males and @ females ) were included in this randomized , open-label , two-period crossover ( @-week washout interval ) bioequivalence study .", "sentence_id": 1}
+{"abstract_id": "24755132", "label": "methods", "text": "Blood samples were collected at pre-dose ( @ hour ) and @ , @ , @ , @ , @ , @ , @ , @ , @ , @ , and @ hours after drug ingestion .", "sentence_id": 2}
+{"abstract_id": "24755132", "label": "methods", "text": "Pharmacokinetic parameters ( Cmax , tmax , t@/@ , AUC@-tlast , and AUC@ - ) were calculated from plasma concentrations for both formulations in each subject .", "sentence_id": 3}
+{"abstract_id": "24755132", "label": "results", "text": "Arithmetic mean values of the pharmacokinetic parameters were : Cmax = @ ( @ ) gmL-@ ; tmax = @ ( @ ) h ; t@/@ = @ ( @ ) h ; AUC@-tlast = @ ( @ ) ghmL-@ ; and AUC@ - = @ ( @ ) ghmL-@ for reference formulation and Cmax = @ ( @ ) gmL-@ ; tmax = @ ( @ ) h ; t@/@ = @ ( @ ) h ; AUC@-tlast = @ ( @ ) ghmL-@ ; and AUC@ - = @ ( @ ) ghmL-@ for test formulation .", "sentence_id": 4}
+{"abstract_id": "24755132", "label": "results", "text": "The confidence intervals ( @ % CI ) for reference and test formulations were , respectively , @ - @ % for Cmax and @ - @ % for AUC@-t .", "sentence_id": 5}
+{"abstract_id": "24755132", "label": "conclusions", "text": "Based on the results , both formulations of amoxicillin evaluated in this study were considered bioequivalent according to FDA and ANVISA/Brazil criteria .", "sentence_id": 6}
+{"abstract_id": "24870622", "label": "objective", "text": "Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity .", "sentence_id": 0}
+{"abstract_id": "24870622", "label": "objective", "text": "However , the specific contribution of the parasympathetic nervous system ( PNS ) is unclear .", "sentence_id": 1}
+{"abstract_id": "24870622", "label": "objective", "text": "We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain .", "sentence_id": 2}
+{"abstract_id": "24870622", "label": "methods", "text": "Prior to , and following , a @-min distal oesophageal infusion of @ M hydrochloric acid , pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects .", "sentence_id": 3}
+{"abstract_id": "24870622", "label": "methods", "text": "Validated sympathetic ( skin conductance response ) and parasympathetic ( cardiac vagal tone ) parameters were measured at baseline and continuously thereafter .", "sentence_id": 4}
+{"abstract_id": "24870622", "label": "methods", "text": "In study @ , @ subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion .", "sentence_id": 5}
+{"abstract_id": "24870622", "label": "methods", "text": "In study @ , @ subjects were randomised in a blinded , crossover design to receive intravenous atropine or placebo ( saline ) with deep breathing during acid infusion .", "sentence_id": 6}
+{"abstract_id": "24870622", "label": "results", "text": "Study @ : Deep breathing increased cardiac vagal tone ( @ vs -@ , p = @ ) with concomitant withdrawal of skin conductance response ( -@ vs @ , p = @ ) in comparison with un-paced breathing .", "sentence_id": 7}
+{"abstract_id": "24870622", "label": "results", "text": "Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24870622", "label": "results", "text": "Study @ : Atropine , in comparison with placebo , blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24870622", "label": "conclusions", "text": "The development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone .", "sentence_id": 10}
+{"abstract_id": "24870622", "label": "conclusions", "text": "This effect is pharmacologically blocked with atropine , providing evidence that the PNS influences the development of oesophageal pain hypersensitivity .", "sentence_id": 11}
+{"abstract_id": "26122460", "label": "objective", "text": "Self-management challenges facing adults with epilepsy include limited understanding of the condition and treatment , associated psychosocial issues , and lack of community integration .", "sentence_id": 0}
+{"abstract_id": "26122460", "label": "objective", "text": "Self-management interventions improve patients ' medical , life role , and emotional management .", "sentence_id": 1}
+{"abstract_id": "26122460", "label": "objective", "text": "Previous interventions , developed from expert opinion , indicated issues with participant engagement/retention , and limited follow-up periods .", "sentence_id": 2}
+{"abstract_id": "26122460", "label": "objective", "text": "PACES in Epilepsy addressed methodologic concerns by utilizing patient needs assessment data ( n = @ ) to derive self-management content and program features for evaluation via randomized controlled trial ( RCT ) .", "sentence_id": 3}
+{"abstract_id": "26122460", "label": "methods", "text": "Participants were adults with chronic epilepsy ( n = @ ) , without serious mental illness or substantive intellectual impairment , who were recruited from two epilepsy centers .", "sentence_id": 4}
+{"abstract_id": "26122460", "label": "methods", "text": "Participants were assigned randomly to intervention or treatment-as-usual groups .", "sentence_id": 5}
+{"abstract_id": "26122460", "label": "methods", "text": "Outcomes included the Epilepsy Self-Management Scale ( ESMS ) , Epilepsy Self-Efficacy Scale ( ESES ) , Quality of Life in Epilepsy-@ ( QOLIE-@ ) , Patient Health Questionnaire-@ ( PHQ-@ ) , and the Generalized Anxiety Disorder-@ ( GAD-@ ) , administered at baseline , postintervention ( @weeks ) , and @months postintervention .", "sentence_id": 6}
+{"abstract_id": "26122460", "label": "methods", "text": "The intervention was an @-week group of @-@ adults co-led by a psychologist and trained peer with epilepsy that met one evening per week at a hospital for @min .", "sentence_id": 7}
+{"abstract_id": "26122460", "label": "methods", "text": "Topics included medical , psychosocial , cognitive , and self-management aspects of epilepsy , in addition to community integration and optimizing epilepsy-related communication .", "sentence_id": 8}
+{"abstract_id": "26122460", "label": "methods", "text": "The treatment group provided satisfaction ratings regarding program features .", "sentence_id": 9}
+{"abstract_id": "26122460", "label": "results", "text": "PACES participants ( n = @ ) improved relative to controls ( n = @ ) on the ESMS ( p < @ ) and subscales -LSB- Information ( p < @ ) ; Lifestyle ( p < @ ) -RSB- ; ESES ( p < @ ) ; and QOLIE-@ ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "26122460", "label": "results", "text": "At @-month follow up , PACES participants remained improved on the ESMS ( p = @ ) and Information subscale ( p = @ ) ; and Energy/Fatigue ( p = @ ) and Medication Effects ( p = @ ) of the QOLIE-@ .", "sentence_id": 11}
+{"abstract_id": "26122460", "label": "results", "text": "Attrition in both groups was low ( @ % in each group ) and all program satisfaction ratings exceeded @ / @ , with leadership ( @ ) , topics ( @ ) , and location ( @ ) as the most highly rated aspects .", "sentence_id": 12}
+{"abstract_id": "26122460", "label": "conclusions", "text": "A consumer generated epilepsy self-management program appears to be a promising intervention from multiple perspectives , particularly in relation to disability management .", "sentence_id": 13}
+{"abstract_id": "25539660", "label": "objective", "text": "Sublingual immunotherapy ( SLIT ) has been described as a significant intervention in the treatment of allergic rhinitis ( AR ) .", "sentence_id": 0}
+{"abstract_id": "25539660", "label": "objective", "text": "However , factors that may predict treatment outcomes with respect to quality of life ( QoL ) results and mainly the role of olfactory function are still being underestimated .", "sentence_id": 1}
+{"abstract_id": "25539660", "label": "objective", "text": "In this study , we investigated determinants that best predict treatment outcomes for QoL , exploring mainly the role of olfaction .", "sentence_id": 2}
+{"abstract_id": "25539660", "label": "methods", "text": "One hundred forty-five patients following SLIT , @ placebo-controls , and @ healthy subjects were studied .", "sentence_id": 3}
+{"abstract_id": "25539660", "label": "methods", "text": "Olfactory function was objectively evaluated using `` Sniffin ' Sticks '' test pre - and post-cessation of SLIT .", "sentence_id": 4}
+{"abstract_id": "25539660", "label": "methods", "text": "Three categories of validated QoL questionnaires were filled out by all subjects : questionnaire specific for olfaction ( Questionnaire of Olfactory Deficits ) , questionnaires for assessing psychology ( Beck Depression Inventory , Zung Depression Scale , State & Trait Anxiety Inventory ) , general Short Form-@ health survey .", "sentence_id": 5}
+{"abstract_id": "25539660", "label": "results", "text": "Statistically significant improvement of olfactory function by @ % and of all QoL questionnaires results ( all P < @ ) was observed on final evaluation .", "sentence_id": 6}
+{"abstract_id": "25539660", "label": "results", "text": "Anosmia , asthma history , and the severity of symptoms-expressed by the Total Symptoms Score-were proven independent determinants of clinically significant improvement in patients ' QoL .", "sentence_id": 7}
+{"abstract_id": "25539660", "label": "conclusions", "text": "Several factors were found that may predict QoL outcomes in AR patients following SLIT .", "sentence_id": 8}
+{"abstract_id": "25351119", "label": "objective", "text": "To evaluate the effect of peer education on postoperative rehabilitation of patients with laryngeal cancer .", "sentence_id": 0}
+{"abstract_id": "25351119", "label": "methods", "text": "From January @ to December @ , @ cases of primary laryngeal cancer were treated with partial or total laryngectomy as well as tracheotomy in the Department of Head and Neck Surgery in Shandong Provincial Hospital .", "sentence_id": 1}
+{"abstract_id": "25351119", "label": "methods", "text": "The patients were randomly divided into experimental group or control group by Stochastic tables law , @ patients in control group accepted only conventional nursing , @ patients in experimental group accepted both conventional nursing and peer education .", "sentence_id": 2}
+{"abstract_id": "25351119", "label": "methods", "text": "The difference in the treatment nursing cooperation attitude , postoperative recovery , postoperative symptoms and the incidence of complications between two groups were evaluated by postoperative quality of life ( UW-QOL ) , Eysenck personality questionnaire ( EPQ ) and coping style questionnaire ( CSQ ) score .", "sentence_id": 3}
+{"abstract_id": "25351119", "label": "methods", "text": "The independent sample T-test and test were used for statistical analysis .", "sentence_id": 4}
+{"abstract_id": "25351119", "label": "results", "text": "The patients of experimental group showed more positive attitude to treatment and care compared to the patients of control group ( = @ , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25351119", "label": "results", "text": "Experimental group had less time in postoperative wound healing time , gastric tube indwelling time and postoperative hospital stay than control group , with statistically significant differences ( t = @ , t = @ , t = @ , respectively , P < @ ) ; Incidence of postoperative discomfort symptoms in experimental group was less than that in control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25351119", "label": "results", "text": "Total score for quality of life ( UW-QOL ) in experimental group was higher than that in control group ( t = @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25351119", "label": "results", "text": "The P and N scores of EPQ in experimental group were lower than those in control group ( t = @ , t = @ , P < @ ) , while the E score of EPQ in experimental group was significantly higher than that in control group ( t = @ , P < @ ) , with no significant difference in the L score of EPQ between two groups ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "25351119", "label": "results", "text": "scores of factor to solve problem and help factor of CSQ in experimental group were higher than those in control group ( t = @ , t = @ , P < @ ) , and the era factor score of experimental group was lower than that of control group ( t = @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25351119", "label": "conclusions", "text": "Peer education can help the patients with laryngectomy to maintain good psychological and mental status , to cooperate actively with treatment , to reduce symptoms and complications , and to shorten the length of hospital stay , improving their postoperative rehabilitation and quality of life .", "sentence_id": 10}
+{"abstract_id": "25272534", "label": "objective", "text": "To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of @ % Diltiazem gel with @ % Glyceryl TriNitrate .", "sentence_id": 0}
+{"abstract_id": "25272534", "label": "methods", "text": "The randomized clinical trial was conducted at Aga Khan University Hospital , Karachi , from February @ , to July @ , @ , and comprised @ adult patients with anal fissure who were equally randomised to either Diltiazem or Glyceryl TriNitrate after taking informed consent .", "sentence_id": 1}
+{"abstract_id": "25272534", "label": "methods", "text": "The creams were applied locally ; the former twice daily , and the latter three times a day for a period of two weeks .", "sentence_id": 2}
+{"abstract_id": "25272534", "label": "methods", "text": "The rest of the treatment was standard .", "sentence_id": 3}
+{"abstract_id": "25272534", "label": "methods", "text": "Patients were followed up in clinic by the principal investigator at two weeks for primary outcome i.e. self-reported symptomatic relief on Visual Analogue Scale , and secondary outcomes i.e. side effects and the overall cost of treatment .", "sentence_id": 4}
+{"abstract_id": "25272534", "label": "results", "text": "Of the total , @ ( @ % ) patients were males and the overall mean age was @ + / - @ years .", "sentence_id": 5}
+{"abstract_id": "25272534", "label": "results", "text": "Patients , who used Diltiazem reported more symptomatic relief than Glyceryl TriNitrate ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25272534", "label": "results", "text": "Side effects were found more in Glyceryl TriNitrate than Diltiazem ( p < @ ) , and most common side effect in the former group was headache in @ ( @ % ) patients .", "sentence_id": 7}
+{"abstract_id": "25272534", "label": "results", "text": "Cost of the treatment was not significantly different between both treatment arms ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25272534", "label": "conclusions", "text": "Chemical sphincterotomy with topical @ % Diltiazem gel is an effective first-line treatment for early symptomatic relief of anal fissures , owing to negligible side effects .", "sentence_id": 9}
+{"abstract_id": "25226476", "label": "objective", "text": "Antenatal magnesium sulfate given to pregnant women at imminent risk of very preterm delivery reduces the risk of cerebral palsy in early childhood , although its effects into school age have not been reported from randomized trials .", "sentence_id": 0}
+{"abstract_id": "25226476", "label": "objective", "text": "To determine the association between exposure to antenatal magnesium sulfate and neurological , cognitive , academic , and behavioral outcomes at school age .", "sentence_id": 1}
+{"abstract_id": "25226476", "label": "methods", "text": "The ACTOMgSO@ was a randomized clinical trial conducted in @ centers in Australia and New Zealand , comparing magnesium sulfate with placebo given to pregnant women ( n = @ magnesium ; n = @ placebo ) for whom imminent birth was planned or expected before @ weeks ' gestation .", "sentence_id": 2}
+{"abstract_id": "25226476", "label": "methods", "text": "Children who survived from the @ centers who participated in the school-age follow-up ( n = @ magnesium ; n = @ placebo ) were invited for an assessment at @ to @ years of age between @ and @ .", "sentence_id": 3}
+{"abstract_id": "25226476", "label": "methods", "text": "Mortality , cerebral palsy , motor function , IQ , basic academic skills , attention and executive function , behavior , growth , and functional outcomes .", "sentence_id": 4}
+{"abstract_id": "25226476", "label": "methods", "text": "Main analyses were imputed for missing data .", "sentence_id": 5}
+{"abstract_id": "25226476", "label": "results", "text": "Of the @ fetuses known to be alive at randomization , the mortality rate to school age was @ % ( @/@ ) in the magnesium sulfate group and @ % ( @/@ ) in the placebo group ( risk ratio -LSB- RR -RSB- , @ ; @ % CI , @-@ @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25226476", "label": "results", "text": "Of @ survivors available for follow-up , outcomes at school age ( corrected age @-@ years ) were determined for @ ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25226476", "label": "results", "text": "Comparing the magnesium sulfate and placebo groups revealed no statistically significant difference in proportions with cerebral palsy ( @/@ -LSB- @ % -RSB- and @/@ -LSB- @ % -RSB- , respectively ; odds ratio -LSB- OR -RSB- , @ ; @ % CI , @-@ @ ; P = @ ) or abnormal motor function ( @/@ -LSB- @ % -RSB- and @/@ -LSB- @ % -RSB- , respectively ; OR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25226476", "label": "results", "text": "There was also little difference between groups on any of the cognitive , behavioral , growth , or functional outcomes .", "sentence_id": 9}
+{"abstract_id": "25226476", "label": "conclusions", "text": "Magnesium sulfate given to pregnant women at imminent risk of birth before @ weeks ' gestation was not associated with neurological , cognitive , behavioral , growth , or functional outcomes in their children at school age , although a mortality advantage can not be excluded .", "sentence_id": 10}
+{"abstract_id": "25226476", "label": "conclusions", "text": "The lack of long-term benefit requires confirmation in additional studies .", "sentence_id": 11}
+{"abstract_id": "26055947", "label": "background", "text": "The U.S. pivotal trial for the self-expanding valve found that among patients with severe aortic stenosis at increased risk for surgery , the @-year survival rate was @ percentage points higher in patients treated with a self-expanding transcatheter aortic valve bioprosthesis than in those treated with a surgical bioprosthesis .", "sentence_id": 0}
+{"abstract_id": "26055947", "label": "objective", "text": "Longer-term clinical outcomes were examined to confirm if this mortality benefit is sustained .", "sentence_id": 1}
+{"abstract_id": "26055947", "label": "methods", "text": "Patients with severe aortic stenosis who were at increased surgical risk were recruited .", "sentence_id": 2}
+{"abstract_id": "26055947", "label": "methods", "text": "Eligible patients were randomly assigned in a @:@ ratio to transcatheter aortic valve replacement with the self-expanding transcatheter valve ( transcatheter aortic valve replacement -LSB- TAVR -RSB- group ) or to aortic valve replacement with a surgical bioprosthesis ( surgical group ) .", "sentence_id": 3}
+{"abstract_id": "26055947", "label": "methods", "text": "The @-year clinical and echocardiographic outcomes were evaluated in these patients .", "sentence_id": 4}
+{"abstract_id": "26055947", "label": "results", "text": "A total of @ patients underwent randomization at @ centers in the United States .", "sentence_id": 5}
+{"abstract_id": "26055947", "label": "results", "text": "The rate of @-year all-cause mortality was significantly lower in the TAVR group ( @ % ) than in the surgical group ( @ % ; log-rank test p < @ ) in the as-treated cohort , with an absolute reduction in risk of @ percentage points .", "sentence_id": 6}
+{"abstract_id": "26055947", "label": "results", "text": "Similar results were foundin the intention-to-treat cohort ( log-rank test p < @ ) .", "sentence_id": 7}
+{"abstract_id": "26055947", "label": "results", "text": "The rate of @-year death or major stroke was significantly lower in the TAVR group ( @ % ) than in the surgical group ( @ % ; log-rank test p = @ ) .", "sentence_id": 8}
+{"abstract_id": "26055947", "label": "conclusions", "text": "In patients with severe aortic stenosis who are at increased surgical risk , the higher rate of survival with a self-expanding TAVR compared with surgery was sustained at @ years .", "sentence_id": 9}
+{"abstract_id": "26055947", "label": "conclusions", "text": "( Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement ; NCT@ ) .", "sentence_id": 10}
+{"abstract_id": "25036417", "label": "background", "text": "A prospective , randomized study examined the effect of interventional preoperative education and orientation for scoliosis surgery ( PEOSS ) on anxiety levels of patients undergoing posterior spinal fusion ( PSF ) .", "sentence_id": 0}
+{"abstract_id": "25036417", "label": "background", "text": "Secondary outcomes analyzed were caregiver anxiety , length of stay , morphine equivalent usage , and patient/caregiver satisfaction .", "sentence_id": 1}
+{"abstract_id": "25036417", "label": "methods", "text": "Patients undergoing PSF were randomly distributed into a control group ( N = @ ) or interventional group ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "25036417", "label": "methods", "text": "All subjects and caregivers completed the State ( current ) - Trait ( typical ) Anxiety Inventory ( STAI ) at different intervals : preoperative appointment , preoperative holding area , postoperative orthopaedic unit , and discharge .", "sentence_id": 3}
+{"abstract_id": "25036417", "label": "methods", "text": "At discharge , patients and caregivers completed a satisfaction survey .", "sentence_id": 4}
+{"abstract_id": "25036417", "label": "results", "text": "Significantly higher state anxiety scores were found compared with baseline at all time intervals in both the control group and PEOSS group .", "sentence_id": 5}
+{"abstract_id": "25036417", "label": "results", "text": "The PEOSS group had higher state anxiety scores than the control group at the postoperative interval ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25036417", "label": "results", "text": "There were no significant differences in the caregiver state anxiety scores between the groups at any time interval .", "sentence_id": 7}
+{"abstract_id": "25036417", "label": "results", "text": "Trait anxiety scores for both groups remained stable over time , establishing that the measurement tool accurately reflected baseline anxiety .", "sentence_id": 8}
+{"abstract_id": "25036417", "label": "results", "text": "No significant differences were found in length of stay or morphine equivalent use .", "sentence_id": 9}
+{"abstract_id": "25036417", "label": "results", "text": "Patient satisfaction scores were higher in the PEOSS group than in the control group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25036417", "label": "conclusions", "text": "PSF was associated with increased anxiety at all time intervals in adolescents in both groups .", "sentence_id": 11}
+{"abstract_id": "25036417", "label": "conclusions", "text": "In the PEOSS group , PSF was associated with increased anxiety in the immediate postoperative period .", "sentence_id": 12}
+{"abstract_id": "25036417", "label": "conclusions", "text": "Despite the increase in anxiety , patient satisfaction was higher in the intervention group .", "sentence_id": 13}
+{"abstract_id": "25036417", "label": "conclusions", "text": "It is likely that patients need age-appropriate information and educational strategies to minimize anxiety during PSF .", "sentence_id": 14}
+{"abstract_id": "25036417", "label": "conclusions", "text": "Further work is underway to study and develop more effective interventional strategies .", "sentence_id": 15}
+{"abstract_id": "25036417", "label": "methods", "text": "Level I study .", "sentence_id": 16}
+{"abstract_id": "25040840", "label": "objective", "text": "This randomized double-blind study was conducted to evaluate the analgesic efficacy and safety of addition of three different doses of dexmedetomidine in caudal ropivacaine compared with plain ropivacaine for postoperative analgesia in pediatric day care patients .", "sentence_id": 0}
+{"abstract_id": "25040840", "label": "methods", "text": "Eighty children of American Society of Anesthesiologists grade I-II , aged @-@ years , undergoing lower abdominal and perineal surgery were included .", "sentence_id": 1}
+{"abstract_id": "25040840", "label": "methods", "text": "Children were randomly allocated into four groups .", "sentence_id": 2}
+{"abstract_id": "25040840", "label": "methods", "text": "Group @ received @ % plain ropivacaine @ mlkg ( -@ ) , while group @ , @ , and @ received dexmedetomidine @ , @ , and @ gkg ( -@ ) , respectively , along with @ % ropivacaine @ mlkg ( -@ ) .", "sentence_id": 3}
+{"abstract_id": "25040840", "label": "methods", "text": "Anesthesia was induced and maintained with sevoflurane and @ % N@O in oxygen .", "sentence_id": 4}
+{"abstract_id": "25040840", "label": "methods", "text": "Children were observed for postoperative pain , nausea-vomiting , agitation , sedation , and adverse effects .", "sentence_id": 5}
+{"abstract_id": "25040840", "label": "methods", "text": "Rescue analgesia was provided with oral paracetamol .", "sentence_id": 6}
+{"abstract_id": "25040840", "label": "results", "text": "Postoperative analgesia was significantly prolonged in all dexmedetomidine groups as compared to plain ropivacaine group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25040840", "label": "results", "text": "All patients in the plain ropivacaine group required rescue analgesia within first @ postoperative hours , while none in the other three groups .", "sentence_id": 8}
+{"abstract_id": "25040840", "label": "results", "text": "None of the patients showed delayed anesthetic emergence .", "sentence_id": 9}
+{"abstract_id": "25040840", "label": "results", "text": "Four patients in the plain ropivacaine group developed agitation , while none in the dexmedetomidine groups .", "sentence_id": 10}
+{"abstract_id": "25040840", "label": "results", "text": "Patients receiving dexmedetomidine @ gkg ( -@ ) were more sedated as compared to the other groups ( P < @ ) , but it did not delay discharge of the patients .", "sentence_id": 11}
+{"abstract_id": "25040840", "label": "conclusions", "text": "All three doses of caudal dexmedetomidine appear to be effective for preventing postoperative pain in pediatric day care patients .", "sentence_id": 12}
+{"abstract_id": "25040840", "label": "conclusions", "text": "Caudal dexmedetomidine used in these doses seems to be safe for day care surgery .", "sentence_id": 13}
+{"abstract_id": "25398374", "label": "objective", "text": "Tofacitinib is an oral Janus kinase ( JAK ) inhibitor for the treatment of rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "25398374", "label": "objective", "text": "The pathways affected by tofacitinib and the effects on gene expression in situ are unknown .", "sentence_id": 1}
+{"abstract_id": "25398374", "label": "objective", "text": "Therefore , tofacitinib effects on synovial pathobiology were investigated .", "sentence_id": 2}
+{"abstract_id": "25398374", "label": "methods", "text": "A randomised , double-blind , phase II serial synovial biopsy study ( A@ ; NCT@ ) in patients with RA with an inadequate methotrexate response .", "sentence_id": 3}
+{"abstract_id": "25398374", "label": "methods", "text": "Patients on background methotrexate received tofacitinib @mg twice daily or placebo for @days .", "sentence_id": 4}
+{"abstract_id": "25398374", "label": "methods", "text": "Synovial biopsies were performed on Days -@ and @ and analysed by immunoassay or quantitative PCR .", "sentence_id": 5}
+{"abstract_id": "25398374", "label": "methods", "text": "Clinical response was determined by disease activity score and European League Against Rheumatism ( EULAR ) response on Day @ in A@ , and at Month @ in a long-term extension study ( A@ ; NCT@ ) .", "sentence_id": 6}
+{"abstract_id": "25398374", "label": "results", "text": "Tofacitinib exposure led to EULAR moderate to good responses ( @/@ patients ) , while placebo was ineffective ( @/@ patients ) on Day @ .", "sentence_id": 7}
+{"abstract_id": "25398374", "label": "results", "text": "Tofacitinib treatment significantly reduced synovial mRNA expression of matrix metalloproteinase ( MMP ) -@ and MMP-@ ( p < @ ) and chemokines CCL@ , CXCL@ and CXCL@ ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25398374", "label": "results", "text": "No overall changes were observed in synovial inflammation score or the presence of T cells , B cells or macrophages .", "sentence_id": 9}
+{"abstract_id": "25398374", "label": "results", "text": "Changes in synovial phosphorylation of signal transducer and activator of transcription @ ( STAT@ ) and STAT@ strongly correlated with @-month clinical responses ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25398374", "label": "results", "text": "Tofacitinib significantly decreased plasma CXCL@ ( p < @ ) at Day @ compared with placebo .", "sentence_id": 11}
+{"abstract_id": "25398374", "label": "conclusions", "text": "Tofacitinib reduces metalloproteinase and interferon-regulated gene expression in rheumatoid synovium , and clinical improvement correlates with reductions in STAT@ and STAT@ phosphorylation .", "sentence_id": 12}
+{"abstract_id": "25398374", "label": "conclusions", "text": "JAK@-mediated interferon and interleukin-@ signalling likely play a key role in the synovial response .", "sentence_id": 13}
+{"abstract_id": "24287222", "label": "background", "text": "Patellar straps or sports tapes are commonly used by athletes with patellar tendinopathy in order to reduce pain and to continue sports participation .", "sentence_id": 0}
+{"abstract_id": "24287222", "label": "background", "text": "Currently , there is no scientific evidence for the effectiveness of a patellar strap or sports tape in the management of this common injury .", "sentence_id": 1}
+{"abstract_id": "24287222", "label": "objective", "text": "To investigate the effect of the use of a patellar strap and sports tape on pain and sports participation in subjects with patellar tendinopathy .", "sentence_id": 2}
+{"abstract_id": "24287222", "label": "methods", "text": "The study is divided into two parts : a randomised controlled crossover experiment and a randomised controlled trial ( parallel group design ) .", "sentence_id": 3}
+{"abstract_id": "24287222", "label": "methods", "text": "@ patients diagnosed with patellar tendinopathy recruited from sports medical centres and physiotherapist practices .", "sentence_id": 4}
+{"abstract_id": "24287222", "label": "methods", "text": "In the first part of the study , participants serve as their own control by performing three functional tests under four different conditions ( patellar strap , sports tape , placebo tape , and no orthosis ) .", "sentence_id": 5}
+{"abstract_id": "24287222", "label": "methods", "text": "In the second part , participants keep a log for two weeks ( control week and intervention week ) about the pain experienced during and after sports and their level of sports participation .", "sentence_id": 6}
+{"abstract_id": "24287222", "label": "methods", "text": "In the intervention week participants will use the orthosis assigned to them during training and competition .", "sentence_id": 7}
+{"abstract_id": "24287222", "label": "methods", "text": "The amount of pain ( both parts of the study ) and sports participation ( second part only ) will be measured .", "sentence_id": 8}
+{"abstract_id": "24287222", "label": "methods", "text": "To analyse the effects of the orthoses a Linear Mixed Model will be used .", "sentence_id": 9}
+{"abstract_id": "24287222", "label": "conclusions", "text": "The knowledge gained in this study can be used by practitioners in their advice for athletes with patellar tendinopathy about using patellar strap and sports tape during sports .", "sentence_id": 10}
+{"abstract_id": "25012934", "label": "objective", "text": "A head-to-head comparison was performed between vascular endothelial growth factor blockade and laser for treatment of diabetic macular edema ( DME ) .", "sentence_id": 0}
+{"abstract_id": "25012934", "label": "methods", "text": "Two similarly designed , double-masked , randomized , phase @ trials , VISTA ( DME ) and VIVID ( DME ) .", "sentence_id": 1}
+{"abstract_id": "25012934", "label": "methods", "text": "We included @ patients ( eyes ) with type @ or @ diabetes mellitus who presented with DME with central involvement .", "sentence_id": 2}
+{"abstract_id": "25012934", "label": "methods", "text": "Eyes received either intravitreal aflibercept injection ( IAI ) @ mg every @ weeks ( @q@ ) , IAI @ mg every @ weeks after @ initial monthly doses ( @q@ ) , or macular laser photocoagulation .", "sentence_id": 3}
+{"abstract_id": "25012934", "label": "methods", "text": "The primary efficacy endpoint was the change from baseline in best-corrected visual acuity ( BCVA ) in Early Treatment Diabetic Retinopathy Study ( ETDRS ) letters at week @ .", "sentence_id": 4}
+{"abstract_id": "25012934", "label": "methods", "text": "Secondary efficacy endpoints at week @ included the proportion of eyes that gained @ letters from baseline and the mean change from baseline in central retinal thickness as determined by optical coherence tomography .", "sentence_id": 5}
+{"abstract_id": "25012934", "label": "results", "text": "Mean BCVA gains from baseline to week @ in the IAI @q@ and @q@ groups versus the laser group were @ and @ versus @ letters ( P < @ ) in VISTA , and @ and @ versus @ letters ( P < @ ) in VIVID .", "sentence_id": 6}
+{"abstract_id": "25012934", "label": "results", "text": "The corresponding proportions of eyes gaining @ letters were @ % and @ % versus @ % ( P < @ ) in VISTA , and @ % and @ % versus @ % ( P < @ ) in VIVID .", "sentence_id": 7}
+{"abstract_id": "25012934", "label": "results", "text": "Similarly , mean reductions in central retinal thickness were @ and @ versus @ m ( P < @ ) in VISTA , and @ and @ versus @ m ( P < @ ) in VIVID .", "sentence_id": 8}
+{"abstract_id": "25012934", "label": "results", "text": "Overall incidences of ocular and nonocular adverse events and serious adverse events , including the Anti-Platelet Trialists ' Collaboration-defined arterial thromboembolic events and vascular deaths , were similar across treatment groups .", "sentence_id": 9}
+{"abstract_id": "25012934", "label": "conclusions", "text": "At week @ , IAI demonstrated significant superiority in functional and anatomic endpoints over laser , with similar efficacy in the @q@ and @q@ groups despite the extended dosing interval in the @q@ group .", "sentence_id": 10}
+{"abstract_id": "25012934", "label": "conclusions", "text": "In general , IAI was well-tolerated .", "sentence_id": 11}
+{"abstract_id": "25552402", "label": "objective", "text": "To determine the effects of food on the pharmacokinetics of sublingual asenapine .", "sentence_id": 0}
+{"abstract_id": "25552402", "label": "methods", "text": "Healthy male volunteers ( n = @ , age @-@ years ) randomly received a single sublingual dose of asenapine @ mg after @ h fasting ( Treatment A , reference ) , after a high-fat meal ( Treatment B ) and after @ h fasting with a high-fat meal at @ h post-dose ( Treatment C ) .", "sentence_id": 1}
+{"abstract_id": "25552402", "label": "methods", "text": "Blood samples were drawn over @ h to measure asenapine plasma concentrations .", "sentence_id": 2}
+{"abstract_id": "25552402", "label": "methods", "text": "Effects of food intake on asenapine pharmacokinetics were assessed using bioequivalence criteria and evaluated using a compartmental modelling analysis .", "sentence_id": 3}
+{"abstract_id": "25552402", "label": "results", "text": "Compared with the reference , mean asenapine exposure ( AUC@-last and AUC@ - ) was approximately @ % lower after intake of a high-fat meal prior to dosing , whereas Cmax decreased by only about @ % .", "sentence_id": 4}
+{"abstract_id": "25552402", "label": "results", "text": "When a high-fat meal was taken @ h post-dose in the fasting state , asenapine concentrations were similar to the reference during the first @ h post-dose .", "sentence_id": 5}
+{"abstract_id": "25552402", "label": "results", "text": "After the meal intake , asenapine concentrations decreased quickly for several hours .", "sentence_id": 6}
+{"abstract_id": "25552402", "label": "results", "text": "Compartmental modelling indicated that a transient @-fold increase in asenapine clearance after eating could explain the asenapine concentration-time profiles for both food regimens .", "sentence_id": 7}
+{"abstract_id": "25552402", "label": "conclusions", "text": "To our knowledge , this is the first study investigating the effect of food upon the sublingual administration of a drug .", "sentence_id": 8}
+{"abstract_id": "25552402", "label": "conclusions", "text": "A high-fat meal taken before or @ h post-dose of sublingual asenapine indirectly caused a transient increase in liver blood flow that resulted in a temporal increase in asenapine clearance .", "sentence_id": 9}
+{"abstract_id": "25552402", "label": "conclusions", "text": "As the effects on asenapine exposure were small and not clinically relevant , no additional restrictions are required for the timing of food intake in relation to asenapine dosing .", "sentence_id": 10}
+{"abstract_id": "25527766", "label": "background", "text": "Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet ( UV ) B-induced @-hydroxyvitamin D -LSB- @ ( OH ) D -RSB- concentrations .", "sentence_id": 0}
+{"abstract_id": "25527766", "label": "background", "text": "In the Food with vitamin D ( VitmaD ) study , we showed that common genetic variants rs@ and rs@ in @-hydroxylase ( CYP@R@ ) and rs@ and rs@ in vitamin D binding protein ( GC ) predict @ ( OH ) D concentrations at late summer and after @-mo consumption of cholecalciferol ( vitamin D ) - fortified bread and milk .", "sentence_id": 1}
+{"abstract_id": "25527766", "label": "objective", "text": "In the current study , called the Vitamin D in genes ( VitDgen ) study , we analyzed associations between the increase in @ ( OH ) D concentrations after a given dose of artificial UVB irradiation and @ single nucleotide polymorphisms located in or near genes involved in vitamin D synthesis , transport , activation , or degradation as previously described for the VitmaD study .", "sentence_id": 2}
+{"abstract_id": "25527766", "label": "objective", "text": "Second , we aimed to determine whether the genetic variations in CYP@R@ and GC have similar effects on @ ( OH ) D concentrations after artificial UVB irradiation and supplementation by vitamin D-fortified bread and milk .", "sentence_id": 3}
+{"abstract_id": "25527766", "label": "methods", "text": "The VitDgen study includes @ healthy Danes who received @ whole-body UVB treatments with a total dose of @ or @ standard erythema doses during a @-d period in winter .", "sentence_id": 4}
+{"abstract_id": "25527766", "label": "methods", "text": "The VitmaD study included @ healthy Danish families who were given vitamin D-fortified bread and milk or placebo for @ mo during the winter .", "sentence_id": 5}
+{"abstract_id": "25527766", "label": "results", "text": "After UVB treatments , rs@ in CYP@R@ and rs@ in GC predicted UVB-induced @ ( OH ) D concentrations as previously shown in the VitmaD study .", "sentence_id": 6}
+{"abstract_id": "25527766", "label": "results", "text": "Compared with noncarriers , carriers of @ risk alleles of rs@ and rs@ had lowest concentrations and smallest increases in @ ( OH ) D concentrations after @ UVB treatments and largest decreases in @ ( OH ) D concentrations after @-mo consumption of vitamin D-fortified bread and milk .", "sentence_id": 7}
+{"abstract_id": "25527766", "label": "conclusions", "text": "Common genetic variants in the CYP@R@ and GC genes modify @ ( OH ) D concentrations in the same manner after artificial UVB-induced vitamin D and consumption of vitamin D-fortified bread and milk .", "sentence_id": 8}
+{"abstract_id": "26180950", "label": "objective", "text": "We evaluated a low-cost strategy for schools to improve the convenience and appeal of drinking water .", "sentence_id": 0}
+{"abstract_id": "26180950", "label": "methods", "text": "We conducted a group-randomized , controlled trial in @ Boston , Massachusetts , schools in April through June @ to test a cafeteria-based intervention .", "sentence_id": 1}
+{"abstract_id": "26180950", "label": "methods", "text": "Signage promoting water and disposable cups were installed near water sources .", "sentence_id": 2}
+{"abstract_id": "26180950", "label": "methods", "text": "Mixed linear regression models adjusting for clustering evaluated the intervention impact on average student water consumption over @ lunch periods .", "sentence_id": 3}
+{"abstract_id": "26180950", "label": "results", "text": "The percentage of students in intervention schools observed drinking water during lunch nearly doubled from baseline to follow-up compared with controls ( + @ % ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "26180950", "label": "results", "text": "The intervention was associated with a @-ounce increase in water intake across all students ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "26180950", "label": "results", "text": "Without cups , children were observed drinking @ ( SE = @ ) ounces of water from fountains ; with cups , @ ( SE = @ ) ounces .", "sentence_id": 6}
+{"abstract_id": "26180950", "label": "results", "text": "The percentage of intervention students observed with sugar-sweetened beverages declined ( -@ % ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26180950", "label": "conclusions", "text": "The current default of providing water through drinking fountains in cafeterias results in low water consumption .", "sentence_id": 8}
+{"abstract_id": "26180950", "label": "conclusions", "text": "This study shows that an inexpensive intervention to improve drinking water 's convenience by providing cups can increase student water consumption .", "sentence_id": 9}
+{"abstract_id": "24975199", "label": "background", "text": "Topical photodynamic therapy ( PDT ) for actinic keratoses ( AK ) is hampered by pain during illumination and inferior efficacy in organ-transplant recipients ( OTR ) .", "sentence_id": 0}
+{"abstract_id": "24975199", "label": "objective", "text": "We assessed ablative fractional laser ( AFL ) - assisted daylight photodynamic therapy ( PDT ) ( AFL-dPDT ) compared with daylight PDT ( dPDT ) , conventional PDT ( cPDT ) and AFL alone ( AFL ) in field treatment of AK in OTR .", "sentence_id": 1}
+{"abstract_id": "24975199", "label": "methods", "text": "In each patient , four areas in the same region were randomized to one treatment with AFL-dPDT , dPDT , cPDT and AFL .", "sentence_id": 2}
+{"abstract_id": "24975199", "label": "methods", "text": "AFL was delivered with a @-nm AFL at @ mJ per pulse , @ W , two stacks , @-s pulse-duration , @ % density .", "sentence_id": 3}
+{"abstract_id": "24975199", "label": "methods", "text": "In dPDT and AFL-dPDT , methyl aminolaevulinate ( MAL ) was applied for @ h without occlusion during daylight exposure .", "sentence_id": 4}
+{"abstract_id": "24975199", "label": "methods", "text": "For cPDT , MAL was occluded for @ h followed by red-light ( @ nm ) irradiation at @ J cm ( -@ ) .", "sentence_id": 5}
+{"abstract_id": "24975199", "label": "methods", "text": "The primary end-point was complete response ( CR ) @ months post-treatment .", "sentence_id": 6}
+{"abstract_id": "24975199", "label": "results", "text": "Sixteen patients with @ AK ( grades I-III ) in field-cancerized skin of the scalp , chest and extremities were treated during August and September @ .", "sentence_id": 7}
+{"abstract_id": "24975199", "label": "results", "text": "After @ months , CR ( AK I-III ) rates were @ % after AFL-dPDT , @ % after dPDT , @ % after cPDT and @ % after AFL ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24975199", "label": "results", "text": "CR rates in AFL-dPDT , dPDT and cPDT were also significantly different ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24975199", "label": "results", "text": "Median maximal pain scores differed significantly during AFL-dPDT ( @ ) , dPDT ( @ ) , AFL ( @ ) and cPDT ( @ ) ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24975199", "label": "results", "text": "Erythema and crusting were more intense following AFL-dPDT than dPDT and cPDT , but only transient hypopigmentation was observed .", "sentence_id": 11}
+{"abstract_id": "24975199", "label": "conclusions", "text": "AFL-dPDT is a novel PDT modality that enhances CR with excellent tolerability compared with dPDT and cPDT in difficult-to-treat AK in OTR .", "sentence_id": 12}
+{"abstract_id": "25537443", "label": "background", "text": "Microprocessor knees have improved the gait and functional abilities of persons with transfemoral amputation .", "sentence_id": 0}
+{"abstract_id": "25537443", "label": "background", "text": "The Genium prosthetic knee offers an advanced sensor and control system designed to decrease impairment by : allowing greater stance phase flexion , easing transitions between gait phases , and compensating for changes in terrain .", "sentence_id": 1}
+{"abstract_id": "25537443", "label": "background", "text": "The aim of this study was to determine differences between the knee flexion angle of persons using the Genium knee , the C-Leg knee , and non-amputee controls ; and to evaluate the impact the prostheses on gait and level of impairment of the user .", "sentence_id": 2}
+{"abstract_id": "25537443", "label": "methods", "text": "This study used a randomized experimental crossover of persons with transfemoral amputation using the Genium and C-Leg microprocessor knees ( n = @ ) , with an observational sample of non-amputee controls ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25537443", "label": "methods", "text": "Gait analysis by @D motion tracking of subjects ambulating at different speeds on level ground and on @ and @ ramps was completed .", "sentence_id": 4}
+{"abstract_id": "25537443", "label": "results", "text": "Use of the Genium resulted in a significant increase in peak knee flexion for swing ( @ , p < @ , d = @ ) and stance ( @ , p < @ , d = @ ) phases relative to C-Leg use .", "sentence_id": 5}
+{"abstract_id": "25537443", "label": "results", "text": "There was a high degree of variability between subjects , and significant differences still remain between the Genium group and the control group 's knee flexion angles for most speeds and slopes .", "sentence_id": 6}
+{"abstract_id": "25537443", "label": "conclusions", "text": "The Genium knee generally increases flexion in swing and stance , potentially decreasing the level of impairment for persons with transfemoral amputation .", "sentence_id": 7}
+{"abstract_id": "25537443", "label": "conclusions", "text": "This study demonstrates functional differences between the C-Leg and Genium knees to help prosthetists determine if the Genium will provide functional benefits to individual patients .", "sentence_id": 8}
+{"abstract_id": "26068325", "label": "objective", "text": "The present study aimed to assess the effects of two different sports training methods - traditional and maturational - on the flexibility of female rhythmic gymnasts at different levels of biological maturation .", "sentence_id": 0}
+{"abstract_id": "26068325", "label": "methods", "text": "The sample consisted of @ children , randomly divided ( by draw ) into six groups of @ children ( eight and nine-years old ) : traditional training group ( TG ) ; maturational training group ( MG ) ; and the control group ( CG ) .", "sentence_id": 1}
+{"abstract_id": "26068325", "label": "methods", "text": "These were subdivided into early , normal and late , based on biological maturation assessment by hand/wrist X-ray examination .", "sentence_id": 2}
+{"abstract_id": "26068325", "label": "methods", "text": "Flexibility was evaluated by angle goniometer testing , applying the LABIFIE protocol .", "sentence_id": 3}
+{"abstract_id": "26068325", "label": "methods", "text": "A Lafayette Goniometer Set and Hoorn-Brasil exercise mat were used and the following exercises were performed : external shoulder rotation ( ESR ) and lumbar flexion ( LF ) .", "sentence_id": 4}
+{"abstract_id": "26068325", "label": "methods", "text": "Both the TG and MG participated in twice-weekly , @-minute rhythmic gymnastics classes over @ weeks .", "sentence_id": 5}
+{"abstract_id": "26068325", "label": "methods", "text": "The TG used the traditional sports training method while the MG executed sporting activities according to biological maturation .", "sentence_id": 6}
+{"abstract_id": "26068325", "label": "methods", "text": "The CG received no special treatment .", "sentence_id": 7}
+{"abstract_id": "26068325", "label": "results", "text": "The results showed a significant improvement ( P < @ ) in the subgroups ( late , normal and early ) for both variables ( ESR = @ and LF = @ ) in the eight and nine-year age groups .", "sentence_id": 8}
+{"abstract_id": "26068325", "label": "results", "text": "Moreover , in relation to division by biological maturity , better results were recorded in the early subgroups .", "sentence_id": 9}
+{"abstract_id": "26068325", "label": "conclusions", "text": "Thus , it can be inferred that , due to the changes in important physical parameters as a result of maturation , selecting children for physical education should not be based solely on chronological , but primarily on biological maturation .", "sentence_id": 10}
+{"abstract_id": "24293753", "label": "objective", "text": "Gender differences in the prevalence of sleep apnea/hypopnea syndrome may be mediated via male sex hormones .", "sentence_id": 0}
+{"abstract_id": "24293753", "label": "objective", "text": "Our objective was to determine the exact pathway for a testosterone-mediated increased propensity for central sleep apnea via blockade of the @-reductase pathway of testosterone conversion by finasteride .", "sentence_id": 1}
+{"abstract_id": "24293753", "label": "methods", "text": "Randomization to oral finasteride vs. sham , single-center study .", "sentence_id": 2}
+{"abstract_id": "24293753", "label": "methods", "text": "Sleep research laboratory .", "sentence_id": 3}
+{"abstract_id": "24293753", "label": "methods", "text": "Fourteen healthy young males without sleep apnea .", "sentence_id": 4}
+{"abstract_id": "24293753", "label": "methods", "text": "Hypocapnia was induced via brief nasal noninvasive positive pressure ventilation during stable NREM sleep .", "sentence_id": 5}
+{"abstract_id": "24293753", "label": "methods", "text": "Cessation of mechanical ventilation resulted in hypocapnic central apnea or hypopnea .", "sentence_id": 6}
+{"abstract_id": "24293753", "label": "results", "text": "The apnea threshold ( AT ) was defined as the end-tidal CO ( P ( ET ) CO ) that demarcated the central apnea closest to the eupneic P ( ET ) CO. .", "sentence_id": 7}
+{"abstract_id": "24293753", "label": "results", "text": "The CO reserve was defined as the difference in P ( ET ) CO between eupnea and AT .", "sentence_id": 8}
+{"abstract_id": "24293753", "label": "results", "text": "The apneic threshold and CO reserve were measured at baseline and repeated after at a minimum of @ month .", "sentence_id": 9}
+{"abstract_id": "24293753", "label": "results", "text": "Administration of finasteride resulted in decreased serum dihydrotestosterone .", "sentence_id": 10}
+{"abstract_id": "24293753", "label": "results", "text": "In the finasteride group , the eupneic ventilatory parameters were unchanged ; however , the AT was decreased ( @ @ mm Hg vs. @ @ mm Hg , P = @ ) and the CO reserve was increased ( -@ @ mm Hg vs. -@ @ mm Hg , P = @ ) at follow-up , with a significantly lower hypocapnic ventilatory response , thus indicating increased breathing stability during sleep .", "sentence_id": 11}
+{"abstract_id": "24293753", "label": "results", "text": "No significant changes were noted in the sham group on follow-up study .", "sentence_id": 12}
+{"abstract_id": "24293753", "label": "conclusions", "text": "Inhibition of testosterone action via the @-reductase pathway may be effective in alleviating breathing instability during sleep , presenting an opportunity for novel therapy for central sleep apnea in selected populations .", "sentence_id": 13}
+{"abstract_id": "24823927", "label": "objective", "text": "Alternative drug therapies are needed for the treatment of portal hypertension .", "sentence_id": 0}
+{"abstract_id": "24823927", "label": "objective", "text": "The aim of this randomized study was to evaluate and compare the effects of carvedilol and nebivolol on the hepatic venous pressure gradient ( HVPG ) response in the patients with liver cirrhosis .", "sentence_id": 1}
+{"abstract_id": "24823927", "label": "methods", "text": "In total , @ cirrhotic patients were randomized into @ groups and treated with carvedilol ( n = @ ) or nebivolol ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24823927", "label": "methods", "text": "HVPG was measured at baseline , @ minutes after the administration of carvedilol ( @ mg ) or nebivolol ( @ mg ) , and after @ days of carvedilol ( @ mg ) or nebivolol ( @ mg ) administered daily .", "sentence_id": 3}
+{"abstract_id": "24823927", "label": "methods", "text": "RESULTS .", "sentence_id": 4}
+{"abstract_id": "24823927", "label": "methods", "text": "Carvedilol significantly reduced HVPG from @ mm Hg ( SD , @ ) to @ mm Hg ( SD , @ ) after @ minutes and to @ mm Hg ( SD , @ ) after @ days ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24823927", "label": "methods", "text": "Nebivolol reduced HVPG from @ mm Hg ( SD , @ ) to @ mm Hg ( SD , @ ) and @ mm Hg ( SD , @ ) , respectively ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24823927", "label": "methods", "text": "Carvedilol effectively decreased HVPG in a greater proportion of the patients after an acute probe ( @ % vs. @ % ) and after @ days of the treatment ( @ % vs. @ % , P < @ ) in comparison with nebivolol .", "sentence_id": 7}
+{"abstract_id": "24823927", "label": "conclusions", "text": "Carvedilol and nebivolol reduce HVPG in cirrhotic patients ; however , the effect of carvedilol on the HVPG reduction might be superior to that of nebivolol , especially after @ days of treatment .", "sentence_id": 8}
+{"abstract_id": "25315663", "label": "objective", "text": "To compare the efficacy and safety of intravitreal aflibercept injection ( IAI ) with macular grid laser photocoagulation for the treatment of macular edema after branch retinal vein occlusion ( BRVO ) .", "sentence_id": 0}
+{"abstract_id": "25315663", "label": "methods", "text": "The VIBRANT study was a double-masked , active-controlled , randomized , phase III trial .", "sentence_id": 1}
+{"abstract_id": "25315663", "label": "methods", "text": "Treatment-nave eyes with macular edema after BRVO were included in the study if the occlusion occurred within @ months and best-corrected visual acuity ( BCVA ) was between @ and @ Early Treatment Diabetic Retinopathy Study ( ETDRS ) letters ( @/@-@ / @ Snellen equivalent ) .", "sentence_id": 2}
+{"abstract_id": "25315663", "label": "methods", "text": "Eyes ( @ eye per patient ) received either IAI @ mg every @ weeks ( n = @ ) from baseline to week @ or grid laser ( n = @ ) at baseline with a single grid laser rescue treatment , if needed , from weeks @ through @ .", "sentence_id": 3}
+{"abstract_id": "25315663", "label": "methods", "text": "The primary outcome measure was the proportion of eyes that gained @ ETDRS letters from baseline BCVA at week @ .", "sentence_id": 4}
+{"abstract_id": "25315663", "label": "methods", "text": "Secondary end points included mean change from baseline BCVA and central retinal thickness ( CRT ) at week @ .", "sentence_id": 5}
+{"abstract_id": "25315663", "label": "results", "text": "The proportion of eyes that gained @ ETDRS letters from baseline at week @ was @ % in the IAI group compared with @ % in the laser group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25315663", "label": "results", "text": "The mean improvement from baseline BCVA at week @ was @ ETDRS letters in the IAI group and @ ETDRS letters in the laser group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25315663", "label": "results", "text": "The mean reduction in CRT from baseline at week @ was @ m in the IAI group and @ m in the laser group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25315663", "label": "results", "text": "Traumatic cataract in an IAI patient was the only ocular serious adverse event ( SAE ) that occurred .", "sentence_id": 9}
+{"abstract_id": "25315663", "label": "results", "text": "There were no cases of intraocular inflammation or endophthalmitis .", "sentence_id": 10}
+{"abstract_id": "25315663", "label": "results", "text": "The incidence of nonocular SAEs was @ % in the IAI group and @ % in the laser group .", "sentence_id": 11}
+{"abstract_id": "25315663", "label": "results", "text": "One Anti-Platelet Trialists ' Collaboration-defined event of nonfatal stroke ( @ % ) and @ death ( @ % ) due to pneumonia occurred during the @ weeks of the study , both in patients in the laser group .", "sentence_id": 12}
+{"abstract_id": "25315663", "label": "conclusions", "text": "Monthly IAI provided significantly greater visual benefit and reduction in CRT at @ weeks than grid laser photocoagulation in eyes with macular edema after BRVO .", "sentence_id": 13}
+{"abstract_id": "24962864", "label": "background", "text": "Patients undergoing sleeve gastrectomy experience a significant amount of postoperative gastrointestinal ( GI ) symptoms .", "sentence_id": 0}
+{"abstract_id": "24962864", "label": "background", "text": "The purpose of our study was to assess the efficacy of omentopexy during laparoscopic sleeve gastrectomy ( LSG ) in reducing postoperative food intolerance and GI symptoms .", "sentence_id": 1}
+{"abstract_id": "24962864", "label": "methods", "text": "Morbidly obese patients undergoing LSG were randomly assigned to have LSG with or without omentopexy from May @ to June @ .", "sentence_id": 2}
+{"abstract_id": "24962864", "label": "methods", "text": "A total of @ patients were recruited with @ patients in each group .", "sentence_id": 3}
+{"abstract_id": "24962864", "label": "methods", "text": "Patients and the symptom scorer were blinded as to the assigned surgery .", "sentence_id": 4}
+{"abstract_id": "24962864", "label": "methods", "text": "All procedures were performed by one of two surgeons utilizing the same surgical technique .", "sentence_id": 5}
+{"abstract_id": "24962864", "label": "methods", "text": "Patients were administered standardized surveys , including the Rhodes Index survey , gastroesophageal reflux disease ( GERD ) impact survey , and Eating Assessment Tool ( EAT ) survey at various time points postoperatively to assess nausea , vomiting , retching , frequency of GI symptoms , and level of distress .", "sentence_id": 6}
+{"abstract_id": "24962864", "label": "results", "text": "There was no significant difference in patient age , percent decrease in BMI at any time point , or length of hospitalization between the two groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24962864", "label": "results", "text": "Furthermore , there was no significant difference in Rhodes Index scores , GERD impact scores , or EAT scores at any time point ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24962864", "label": "results", "text": "Patients in the LSG with omentopexy group required significantly more ondansetron perioperatively ( @ @ mg vs. @ @ mg , respectively ; P = @ ) ; however , there was no difference in metoclopramide requirement ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24962864", "label": "results", "text": "Surgical morbidity was not significantly different between the two groups ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "24962864", "label": "results", "text": "Finally , there was no significant difference in number of postoperative clinic visits , office telephone encounters , total postoperative readmissions , or postoperative readmissions associated with GI symptoms ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "24962864", "label": "conclusions", "text": "Omentopexy did not significantly decrease postoperative food intolerance or GI symptoms in morbidly obese patients undergoing LSG .", "sentence_id": 12}
+{"abstract_id": "24962864", "label": "conclusions", "text": "Other methods of mitigating postoperative intolerance to oral intake and GI symptoms should be investigated .", "sentence_id": 13}
+{"abstract_id": "24641742", "label": "objective", "text": "The rehabilitation program after flexor tendon repair of zone II laceration varies .", "sentence_id": 0}
+{"abstract_id": "24641742", "label": "objective", "text": "We designed a Prospective Randomized Controlled Trial of controlled passive mobilization ( modified Kleinert ) vs. Place and active hold exercises after zone @-flexor tendon repair by two-strand suture ( Modified kessler ) .", "sentence_id": 1}
+{"abstract_id": "24641742", "label": "methods", "text": "Sixty-four fingers in @ patients with zone @ flexor tendon modified Kessler repairs were enrolled in a prospective randomized controlled trial comparing place and active hold exercises to controlled passive mobilization ( modified Kleinert ) .", "sentence_id": 2}
+{"abstract_id": "24641742", "label": "methods", "text": "The primary outcome measure was total active motion eight weeks after repair as measured by an independent and blinded therapist .", "sentence_id": 3}
+{"abstract_id": "24641742", "label": "results", "text": "Patients treated with place and active hold exercises had significantly greater total active motion ( @ ) eight weeks after surgery than patients treated with controlled passive mobilization ( @ ) ( modified Klinert ) .", "sentence_id": 4}
+{"abstract_id": "24641742", "label": "results", "text": "There were no ruptures in either group .", "sentence_id": 5}
+{"abstract_id": "24641742", "label": "conclusions", "text": "Place and hold achieves greater motion than controlled passive mobilization after a two-strand repair for zone @ flexor tendon repairs .", "sentence_id": 6}
+{"abstract_id": "25710763", "label": "objective", "text": "To determine whether directly measured arterial blood pressure differs among anatomic locations and whether arterial blood pressure is influenced by body position .", "sentence_id": 0}
+{"abstract_id": "25710763", "label": "methods", "text": "@ client-owned dogs undergoing anesthesia .", "sentence_id": 1}
+{"abstract_id": "25710763", "label": "methods", "text": "Dogs undergoing anesthetic procedures had @-gauge catheters placed in both the superficial palmar arch and the contralateral dorsal pedal artery ( group @ -LSB- n = @ -RSB- ) or the superficial palmar arch and median sacral artery ( group @ -LSB- @ -RSB- ) .", "sentence_id": 2}
+{"abstract_id": "25710763", "label": "methods", "text": "Dogs were positioned in dorsal recumbency , and mean arterial blood pressure ( MAP ) , systolic arterial blood pressure ( SAP ) , and diastolic arterial blood pressure ( DAP ) were recorded for both arteries @ times ( @-minute interval between successive measurements ) .", "sentence_id": 3}
+{"abstract_id": "25710763", "label": "methods", "text": "Dogs were positioned in right lateral recumbency , and blood pressure measurements were repeated .", "sentence_id": 4}
+{"abstract_id": "25710763", "label": "results", "text": "Differences were detected between pressures measured at the @ arterial sites in both groups .", "sentence_id": 5}
+{"abstract_id": "25710763", "label": "results", "text": "This was especially true for SAP measurements in group @ , in which hind limb measurements were a mean of @ mm Hg higher than carpus measurements when dogs were in dorsal recumbency and @ mm Hg higher than carpus measurements when dogs were in lateral recumbency .", "sentence_id": 6}
+{"abstract_id": "25710763", "label": "results", "text": "Also , there was significant dispersion about the mean for all SAP , DAP , and MAP measurements .", "sentence_id": 7}
+{"abstract_id": "25710763", "label": "conclusions", "text": "Results suggested that arterial blood pressures may be dependent on anatomic location and body position .", "sentence_id": 8}
+{"abstract_id": "25710763", "label": "conclusions", "text": "Because this may affect outcomes of studies conducted to validate indirect blood pressure measurement systems , care must be used when developing future studies or interpreting previous results .", "sentence_id": 9}
+{"abstract_id": "25444803", "label": "objective", "text": "This study was designed to identify the optimal dose of an MF@-adjuvanted , monovalent , A/H@N@ influenza vaccine in healthy paediatric subjects .", "sentence_id": 0}
+{"abstract_id": "25444803", "label": "methods", "text": "Subjects aged @-@ years ( n = @ ) and @-@ years ( n = @ ) were randomized to receive two primary doses of A/H@N@ vaccine containing either @ g antigen with half a standard dose of MF@ adjuvant , @ g antigen with a full dose of MF@ , or ( children @-@ years only ) , a non-adjuvanted @ g formulation .", "sentence_id": 1}
+{"abstract_id": "25444803", "label": "methods", "text": "A booster dose of MF@-adjuvanted seasonal influenza vaccine including homologous A/H@N@ strain was given one year after priming .", "sentence_id": 2}
+{"abstract_id": "25444803", "label": "methods", "text": "Immunogenicity was assessed by haemagglutination inhibition ( HI ) and microneutralization assays .", "sentence_id": 3}
+{"abstract_id": "25444803", "label": "methods", "text": "Vaccine safety was assessed throughout the study ( up to @ months ) .", "sentence_id": 4}
+{"abstract_id": "25444803", "label": "results", "text": "A single priming dose of either MF@-adjuvanted formulation was sufficient to meet the European licensure criteria for pandemic influenza vaccines ( HI titres @:@ > @ % ; seroconversion > @ % ; and GMR > @ ) .", "sentence_id": 5}
+{"abstract_id": "25444803", "label": "results", "text": "Two non-adjuvanted vaccine doses were required to meet the same licensure criteria .", "sentence_id": 6}
+{"abstract_id": "25444803", "label": "results", "text": "After first and second doses , percentage of subjects with HI titres @:@ were between @ % and @ % in the adjuvanted vaccine groups compared with @ % and @ % in the non-adjuvanted group , respectively .", "sentence_id": 7}
+{"abstract_id": "25444803", "label": "results", "text": "Postvaccination seroconversion rates ranged from @ % to @ % in adjuvanted groups and were @ % ( first dose ) and @ % ( second dose ) in the non-adjuvanted group .", "sentence_id": 8}
+{"abstract_id": "25444803", "label": "results", "text": "HI titres @:@ after primary doses were achieved in @ % to @ % in adjuvanted groups compared with @ % in the non-adjuvanted group .", "sentence_id": 9}
+{"abstract_id": "25444803", "label": "results", "text": "Long-term antibody persistence after priming and a robust antibody response to booster immunization were observed in all vaccination groups .", "sentence_id": 10}
+{"abstract_id": "25444803", "label": "results", "text": "All A/H@N@ vaccine formulations were generally well tolerated .", "sentence_id": 11}
+{"abstract_id": "25444803", "label": "results", "text": "No vaccine-related serious adverse events occurred , and no subjects were withdrawn from the study due to an adverse event .", "sentence_id": 12}
+{"abstract_id": "25444803", "label": "conclusions", "text": "An MF@-adjuvanted influenza vaccine containing @ g of A/H@N@ antigen was well tolerated and sufficiently immunogenic to meet all the European licensure criteria after a single dose in healthy children @-@ years old .", "sentence_id": 13}
+{"abstract_id": "24576316", "label": "objective", "text": "To evaluate the analgesic potential of the centrally acting analgesics tramadol , morphine and the novel analgesic tapentadol in a pre-clinical research model of acute nociceptive pain , the tail-flick model in dogs .", "sentence_id": 0}
+{"abstract_id": "24576316", "label": "methods", "text": "Prospective part-randomized pre-clinical research trial .", "sentence_id": 1}
+{"abstract_id": "24576316", "label": "methods", "text": "Fifteen male Beagle dogs ( HsdCpb : DOBE ) , aged @-@ months .", "sentence_id": 2}
+{"abstract_id": "24576316", "label": "methods", "text": "On different occasions separated by at least @ week , dogs received intravenous ( IV ) administrations of tramadol ( @ , @ mg kg ( -@ ) ) , tapentadol ( @ , @ , @ mg kg ( -@ ) ) or morphine ( @ , @ , @ mg kg ( -@ ) ) with subsequent measurement of tail withdrawal latencies from a thermal stimulus ( for each treatment n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24576316", "label": "methods", "text": "Blood samples were collected immediately after the pharmacodynamic measurements of tramadol to determine pharmacokinetics and the active metabolite O-demethyltramadol ( M@ ) .", "sentence_id": 4}
+{"abstract_id": "24576316", "label": "results", "text": "Tapentadol and morphine induced dose-dependent antinociception with ED@-values of @ mg kg ( -@ ) and @ mg kg ( -@ ) , respectively .", "sentence_id": 5}
+{"abstract_id": "24576316", "label": "results", "text": "In contrast , tramadol did not induce antinociception at any dose tested .", "sentence_id": 6}
+{"abstract_id": "24576316", "label": "results", "text": "Measurements of the serum levels of tramadol and the M@ metabolite revealed only marginal amounts of the M@ metabolite , which explains the absence of the antinociceptive effect of tramadol in this experimental pain model in dogs .", "sentence_id": 7}
+{"abstract_id": "24576316", "label": "conclusions", "text": "Different breeds of dogs might not or only poorly respond to treatment with tramadol due to low metabolism of the drug .", "sentence_id": 8}
+{"abstract_id": "24576316", "label": "conclusions", "text": "Tapentadol and morphine which act directly on - opioid receptors without the need for metabolic activation are demonstrated to induce potent antinociception in the experimental model used and should also provide a reliable pain management in the clinical situation .", "sentence_id": 9}
+{"abstract_id": "24576316", "label": "conclusions", "text": "The non-opioid mechanisms of tramadol do not provide antinociception in this experimental setting .", "sentence_id": 10}
+{"abstract_id": "24576316", "label": "conclusions", "text": "This contrasts to many clinical situations described in the literature , where tramadol appears to provide useful analgesia in dogs for post-operative pain relief and in more chronically pain states .", "sentence_id": 11}
+{"abstract_id": "24226381", "label": "background", "text": "This paper describes a randomized prospective study conducted in @ patients undergoing caesarean section in spinal anaesthesia at a single hospital between @ and @ to find a suitable anti-emetic strategy for these patients .", "sentence_id": 0}
+{"abstract_id": "24226381", "label": "methods", "text": "Spinal anesthesia was performed in left prone position , at L@/L@ with hyperbaric @ % Bupivacaine according to a cc/cm body height ratio .", "sentence_id": 1}
+{"abstract_id": "24226381", "label": "methods", "text": "There were no opioids given peri-operatively .", "sentence_id": 2}
+{"abstract_id": "24226381", "label": "methods", "text": "The patients received either no prophylaxis ( Group I ) or tropisetron and metoclopramide ( Group II ) or dimenhydrinate and dexamethasone ( Group III ) , or tropisetron as a single medication ( Group IV ) .", "sentence_id": 3}
+{"abstract_id": "24226381", "label": "methods", "text": "The primary outcome was nausea and/or vomiting ( NV ) in the intraoperative , early ( @-@ h ) or late ( @-@ h ) postoperative period .", "sentence_id": 4}
+{"abstract_id": "24226381", "label": "methods", "text": "Multivariate statistical analysis was conducted with a regression analysis and a backward elimination of factors without significant correlation .", "sentence_id": 5}
+{"abstract_id": "24226381", "label": "results", "text": "All prophylactic agents significantly reduced NV incidence intraoperatively .", "sentence_id": 6}
+{"abstract_id": "24226381", "label": "results", "text": "Relative risk reduction for NV by prophylaxis was most effective ( @ % ) in Group II ( tropisetron and metoclopramide ) .", "sentence_id": 7}
+{"abstract_id": "24226381", "label": "results", "text": "In Group III ( dimenhydrinate and dexamethasone ) , NV risk was reduced by @ % and by @ % in Group IV ( tropisetron mono-therapy ) .", "sentence_id": 8}
+{"abstract_id": "24226381", "label": "results", "text": "The incidence of NV in the early ( @ ?", "sentence_id": 9}
+{"abstract_id": "24226381", "label": "results", "text": "@ h ) and the late ( @ ?", "sentence_id": 10}
+{"abstract_id": "24226381", "label": "results", "text": "@ h ) postoperative period was low all over ( @ % ) , but the relative risk reduction of NV in the early postoperative period was @ % ( Group IV ) , @ % ( Group III ) , and @ % ( Group II ) , respectively .", "sentence_id": 11}
+{"abstract_id": "24226381", "label": "results", "text": "In the late postoperative period , there was no significant difference between the @ groups .", "sentence_id": 12}
+{"abstract_id": "24226381", "label": "conclusions", "text": "We recommend a prophylactic medication with tropisetron @ mg and metoclopramide @ mg for patients during caesarean section .", "sentence_id": 13}
+{"abstract_id": "24226381", "label": "conclusions", "text": "These agents are safe , reasonably priced , and highly efficient in preventing nausea and vomiting .", "sentence_id": 14}
+{"abstract_id": "24999104", "label": "objective", "text": "To explore whether topical application of atropine gel controls epiphora secondary to submandibular gland ( SMG ) transplantion for severe keratoconjunctivitis sicca .", "sentence_id": 0}
+{"abstract_id": "24999104", "label": "methods", "text": "Eighteen patients with epiphora after SMG transplantation participated in a double-blind , controlled , crossover study .", "sentence_id": 1}
+{"abstract_id": "24999104", "label": "methods", "text": "Patients were treated with topical smear common atropine ( CA ) and modified atropine ( MA ) gels ( intervals @ day ) .", "sentence_id": 2}
+{"abstract_id": "24999104", "label": "methods", "text": "The control effect of atropine gels was observed for @ hours .", "sentence_id": 3}
+{"abstract_id": "24999104", "label": "methods", "text": "Tear flow was quantified in resting and stimulated ( after exercise ) states using the Schirmer I test .", "sentence_id": 4}
+{"abstract_id": "24999104", "label": "results", "text": "With the CA gel , tear flow decreased significantly at @ , @ , and @ minutes .", "sentence_id": 5}
+{"abstract_id": "24999104", "label": "results", "text": "Average epiphora reduction rates ( AERRs ) were @ % , @ % , and @ % , respectively ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24999104", "label": "results", "text": "With the MA gel , tear flow decreased significantly from @ minutes to @ hours ; AERRs increased from @ % to @ % ( P < @ ) ; Maximum efficacy was maintained from @ minutes to @ hours ( P < @ ) ; Tear flow gradually increased from @ to @ hours but was still lower than that before atropine use ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24999104", "label": "results", "text": "According to results of the Schirmer I test and AERRs , the control efficacy of the MA gel was significantly better than that of the CA gel ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24999104", "label": "conclusions", "text": "Topical application of atropine gel could effectively control mild epiphora for patients with SMG transplantation for severe keratoconjunctivitis sicca .", "sentence_id": 9}
+{"abstract_id": "24999104", "label": "conclusions", "text": "The efficacy of MA gel was much better than that of the CA gel .", "sentence_id": 10}
+{"abstract_id": "24811963", "label": "objective", "text": "Eye drops of aganirsen , an antisense oligonucleotide preventing insulin receptor substrate-@ expression , inhibited corneal neovascularization in a previous dose-finding phase II study .", "sentence_id": 0}
+{"abstract_id": "24811963", "label": "objective", "text": "We aimed to confirm these results in a phase III study and investigated a potential clinical benefit on visual acuity ( VA ) , quality of life ( QoL ) , and need for transplantation .", "sentence_id": 1}
+{"abstract_id": "24811963", "label": "methods", "text": "Multicenter , double-masked , randomized , placebo-controlled phase III study .", "sentence_id": 2}
+{"abstract_id": "24811963", "label": "methods", "text": "Analysis of @ patients with keratitis-related progressive corneal neovascularization randomized to aganirsen ( @ patients ) or placebo ( @ patients ) .", "sentence_id": 3}
+{"abstract_id": "24811963", "label": "methods", "text": "Patients applied aganirsen eye drops ( @ g/day/eye ) or placebo twice daily for @ days and were followed up to day @ .", "sentence_id": 4}
+{"abstract_id": "24811963", "label": "methods", "text": "The primary end point was VA. .", "sentence_id": 5}
+{"abstract_id": "24811963", "label": "methods", "text": "Secondary end points included area of pathologic corneal neovascularization , need for transplantation , risk of graft rejection , and QoL .", "sentence_id": 6}
+{"abstract_id": "24811963", "label": "results", "text": "Although no significant differences in VA scores between groups were observed , aganirsen significantly reduced the relative corneal neovascularization area after @ days by @ % ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24811963", "label": "results", "text": "This improvement persisted after @ days ( @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24811963", "label": "results", "text": "Aganirsen tended to lower the transplantation need in the intent-to-treat ( ITT ) population at day @ ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24811963", "label": "results", "text": "In patients with viral keratitis and central neovascularization , a significant reduction in transplantation need was achieved ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24811963", "label": "results", "text": "No significant differences between groups were observed in the risk of graft rejection .", "sentence_id": 11}
+{"abstract_id": "24811963", "label": "results", "text": "However , aganirsen tended to decrease this risk in patients with traumatic/viral keratitis ( P = @ ) at day @ .", "sentence_id": 12}
+{"abstract_id": "24811963", "label": "results", "text": "The QoL analyses revealed a significant improvement with aganirsen in composite and near activity subscores ( P = @ and @ , respectively ) at day @ in the per protocol population .", "sentence_id": 13}
+{"abstract_id": "24811963", "label": "results", "text": "Ocular and treatment-related treatment-emergent adverse events ( TEAEs ) were reported in a lower percentage with aganirsen compared with placebo .", "sentence_id": 14}
+{"abstract_id": "24811963", "label": "results", "text": "Only @ serious TEAEs ( @ with aganirsen and @ with placebo ) were considered treatment-related .", "sentence_id": 15}
+{"abstract_id": "24811963", "label": "conclusions", "text": "This first phase III study on a topical inhibitor of corneal angiogenesis showed that aganirsen eye drops significantly inhibited corneal neovascularization in patients with keratitis .", "sentence_id": 16}
+{"abstract_id": "24811963", "label": "conclusions", "text": "The need for transplantation was significantly reduced in patients with viral keratitis and central neovascularization .", "sentence_id": 17}
+{"abstract_id": "24811963", "label": "conclusions", "text": "Topical application of aganirsen was safe and well tolerated .", "sentence_id": 18}
+{"abstract_id": "24232133", "label": "background", "text": "Structural learning theory suggests that experiencing motor task variation enables the central nervous system to extract general rules regarding tasks with a similar structure - rules that can subsequently be applied to novel situations .", "sentence_id": 0}
+{"abstract_id": "24232133", "label": "background", "text": "Complex minimally invasive surgery ( MIS ) requires different port sites , but switching ports alters the limb movements required to produce the same endpoint control of the surgical instrument .", "sentence_id": 1}
+{"abstract_id": "24232133", "label": "background", "text": "The purpose of the present study was to determine if structural learning theory can be applied to MIS to inform training methods .", "sentence_id": 2}
+{"abstract_id": "24232133", "label": "methods", "text": "A tablet laptop running bespoke software was placed within a laparoscopic box trainer and connected to a monitor situated at eye level .", "sentence_id": 3}
+{"abstract_id": "24232133", "label": "methods", "text": "Participants ( right-handed , non-surgeons , mean age = @ years ) used a standard laparoscopic grasper to move between locations on the screen .", "sentence_id": 4}
+{"abstract_id": "24232133", "label": "methods", "text": "There were two training groups : the M group ( n = @ ) who trained using multiple port sites , and the S group ( n = @ ) who trained using a single port site .", "sentence_id": 5}
+{"abstract_id": "24232133", "label": "methods", "text": "A novel port site was used as a test of generalization .", "sentence_id": 6}
+{"abstract_id": "24232133", "label": "methods", "text": "Performance metrics were a composite of speed and accuracy ( SACF ) and normalized jerk ( NJ ; a measure of movement ` smoothness ' ) .", "sentence_id": 7}
+{"abstract_id": "24232133", "label": "results", "text": "The M group showed a statistically significant performance advantage over the S group at test , as indexed by improved SACF ( p < @ ) and NJ ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24232133", "label": "conclusions", "text": "This study has demonstrated the potential benefits of incorporating a structural learning approach within MIS training .", "sentence_id": 9}
+{"abstract_id": "24232133", "label": "conclusions", "text": "This may have practical applications when training junior surgeons and developing surgical simulation devices .", "sentence_id": 10}
+{"abstract_id": "24772521", "label": "background", "text": "The Randomized Olmesartan and Diabetes Microalbuminuria Prevention ( ROADMAP ) study showed that @ mg Olmesartan medoxomil ( OM ) versus placebo delayed microalbuminuria onset in patients with type @ diabetes and normoalbuminuria .", "sentence_id": 0}
+{"abstract_id": "24772521", "label": "results", "text": "One thousand seven hundred and fifty-eight ROADMAP patients ( placebo arm : @ ; OM arm : @ ) participated in the observational follow up ( OFU ) with an average of @ years .", "sentence_id": 1}
+{"abstract_id": "24772521", "label": "results", "text": "They received standard medical care and micro - and macrovascular events were documented .", "sentence_id": 2}
+{"abstract_id": "24772521", "label": "results", "text": "During observational follow-up @ % and @ % in the former OM and placebo group , respectively , received treatment with a RAS blocking agent .", "sentence_id": 3}
+{"abstract_id": "24772521", "label": "results", "text": "During the OFU period the systolic blood pressure ( SBP ) increased to mean values of @ mm Hg in both groups .", "sentence_id": 4}
+{"abstract_id": "24772521", "label": "results", "text": "Patients who had developed microalbuminuria during ROADMAP had a higher incidence of cardio - and cerebrovascular events ( OR @ , CI @ to @ , P = @ ) during the OFU period compared with patients in whom this was not the case .", "sentence_id": 5}
+{"abstract_id": "24772521", "label": "results", "text": "Diabetic retinopathy was significantly reduced in the former OM group ( @ -LSB- @ % -RSB- versus @ -LSB- @ % -RSB- , OR : @ , CI @ to @ , P = @ ) and the rate of microalbuminuria was numerically reduced .", "sentence_id": 6}
+{"abstract_id": "24772521", "label": "results", "text": "Congestive heart failure requiring hospitalization ( @ -LSB- @ % -RSB- versus @ -LSB- @ % -RSB- , OR : @ , CI @ to @ , P = @ ) was reduced and there was a trend of reduced cardio - / cerebrovascular events ( OM versus Pb : @ -LSB- @ % -RSB- versus @ -LSB- @ % -RSB- patients ) .", "sentence_id": 7}
+{"abstract_id": "24772521", "label": "results", "text": "Seven ( @ % ) deaths ( including @ CV events ) were reported in former placebo patients versus @ ( @ % ) ( non-CV events ) in former OM patients .", "sentence_id": 8}
+{"abstract_id": "24772521", "label": "conclusions", "text": "Development of microalbuminuria is a valid marker for future CV events .", "sentence_id": 9}
+{"abstract_id": "24772521", "label": "conclusions", "text": "RAS blockade with Olmesartan might cause sustained reduction ( legacy effect ) of micro - and macrovascular events .", "sentence_id": 10}
+{"abstract_id": "25892679", "label": "background", "text": "Early mobilisation after stroke is thought to contribute to the effects of stroke-unit care ; however , the intervention is poorly defined and not underpinned by strong evidence .", "sentence_id": 0}
+{"abstract_id": "25892679", "label": "background", "text": "We aimed to compare the effectiveness of frequent , higher dose , very early mobilisation with usual care after stroke .", "sentence_id": 1}
+{"abstract_id": "25892679", "label": "methods", "text": "We did this parallel-group , single-blind , randomised controlled trial at @ acute stroke units in five countries .", "sentence_id": 2}
+{"abstract_id": "25892679", "label": "methods", "text": "Patients ( aged @ years ) with ischaemic or haemorrhagic stroke , first or recurrent , who met physiological criteria were randomly assigned ( @:@ ) , via a web-based computer generated block randomisation procedure ( block size of six ) , to receive usual stroke-unit care alone or very early mobilisation in addition to usual care .", "sentence_id": 3}
+{"abstract_id": "25892679", "label": "methods", "text": "Treatment with recombinant tissue plasminogen activator was allowed .", "sentence_id": 4}
+{"abstract_id": "25892679", "label": "methods", "text": "Randomisation was stratified by study site and stroke severity .", "sentence_id": 5}
+{"abstract_id": "25892679", "label": "methods", "text": "Patients , outcome assessors , and investigators involved in trial and data management were masked to treatment allocation .", "sentence_id": 6}
+{"abstract_id": "25892679", "label": "methods", "text": "The primary outcome was a favourable outcome @ months after stroke , defined as a modified Rankin Scale score of @-@ .", "sentence_id": 7}
+{"abstract_id": "25892679", "label": "methods", "text": "We did analysis on an intention-to-treat basis .", "sentence_id": 8}
+{"abstract_id": "25892679", "label": "methods", "text": "The trial is registered with the Australian New Zealand Clinical Trials Registry , number ACTRN@ .", "sentence_id": 9}
+{"abstract_id": "25892679", "label": "results", "text": "Between July @ , @ , and Oct @ , @ , we randomly assigned @ patients to receive either very early mobilisation ( n = @ ) or usual care ( n = @ ) ; @ ( @ % ) patients were included in the @ month follow-up assessment .", "sentence_id": 10}
+{"abstract_id": "25892679", "label": "results", "text": "@ ( @ % ) patients were mobilised within @ h in the very early mobilisation group compared with @ ( @ % ) patients in the usual care group .", "sentence_id": 11}
+{"abstract_id": "25892679", "label": "results", "text": "Fewer patients in the very early mobilisation group had a favourable outcome than those in the usual care group ( n = @ -LSB- @ % -RSB- vs n = @ -LSB- @ % -RSB- ; adjusted odds ratio -LSB- OR -RSB- @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25892679", "label": "results", "text": "@ ( @ % ) patients died in the very early mobilisation group compared with @ ( @ % ) patients in the usual care group ( OR @ , @ % CI @-@ , p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25892679", "label": "results", "text": "@ ( @ % ) patients in the very early mobilisation group and @ ( @ % ) of those in the usual care group had a non-fatal serious adverse event , with no reduction in immobility-related complications with very early mobilisation .", "sentence_id": 14}
+{"abstract_id": "25892679", "label": "conclusions", "text": "First mobilisation took place within @ h for most patients in this trial .", "sentence_id": 15}
+{"abstract_id": "25892679", "label": "conclusions", "text": "The higher dose , very early mobilisation protocol was associated with a reduction in the odds of a favourable outcome at @ months .", "sentence_id": 16}
+{"abstract_id": "25892679", "label": "conclusions", "text": "Early mobilisation after stroke is recommended in many clinical practice guidelines worldwide , and our findings should affect clinical practice by refining present guidelines ; however , clinical recommendations should be informed by future analyses of dose-response associations .", "sentence_id": 17}
+{"abstract_id": "26180474", "label": "background", "text": "To assess the short-term efficacy and safety of corneal collagen cross-linking ( CXL ) in preventing the progression of keratoconus ( KCN ) .", "sentence_id": 0}
+{"abstract_id": "26180474", "label": "methods", "text": "This randomized controlled clinical trial enrolled @ patients diagnosed with bilateral progressive KCN and were eligible for CXL .", "sentence_id": 1}
+{"abstract_id": "26180474", "label": "methods", "text": "In each patient , one eye was randomly selected for treatment , and the contralateral eye served as the control .", "sentence_id": 2}
+{"abstract_id": "26180474", "label": "methods", "text": "The patients underwent CXL with riboflavin drops and ultraviolet radiation in the treated eye .", "sentence_id": 3}
+{"abstract_id": "26180474", "label": "methods", "text": "One year follow-up data are presented .", "sentence_id": 4}
+{"abstract_id": "26180474", "label": "methods", "text": "Postoperatively , patients were assessed for progression of KCN , visual changes , and other findings .", "sentence_id": 5}
+{"abstract_id": "26180474", "label": "methods", "text": "The main outcome measures were maximum simulated keratometry ( K-max ) , best spectacle-corrected visual acuity ( BSCVA ) , and average simulated keratometry .", "sentence_id": 6}
+{"abstract_id": "26180474", "label": "methods", "text": "P < @ was considered as statistically significant .", "sentence_id": 7}
+{"abstract_id": "26180474", "label": "results", "text": "In the treated eyes , the mean K-max values decreased by @ D at @-year postoperatively and increased by @ D in the control group .", "sentence_id": 8}
+{"abstract_id": "26180474", "label": "results", "text": "This difference was statistically significant ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "26180474", "label": "results", "text": "BSCVA improved slightly ( a decrease of @ LogMAR ) and decreased slightly in the control group ( a @ LogMAR increase ) .", "sentence_id": 10}
+{"abstract_id": "26180474", "label": "results", "text": "The difference between groups was statistically significant ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "26180474", "label": "results", "text": "There was no decrease in visual acuity attributable to complications of CXL in the treated eyes .", "sentence_id": 12}
+{"abstract_id": "26180474", "label": "results", "text": "At @-year , the keratometry in @ ( @ % ) treated eyes increased by more than @ D and were considered cases of failed treatment .", "sentence_id": 13}
+{"abstract_id": "26180474", "label": "conclusions", "text": "Preliminary and @-year results indicate CXL can halt the progression of KCN in most cases without causing serious complications .", "sentence_id": 14}
+{"abstract_id": "25311746", "label": "background", "text": "We describe the organization of a prospective , randomized , multicenter trial comparing the effectiveness of open popliteal artery aneurysm repair ( OPAR ) and endovascular popliteal artery aneurysm repair ( EPAR ) of asymptomatic popliteal artery aneurysms ( PAAs ) as an example for how to use the Vascular Quality Initiative ( VQI ) framework .", "sentence_id": 0}
+{"abstract_id": "25311746", "label": "background", "text": "Given that many centers participate in the VQI , this model can be used to perform multicenters ' prospective trials on very modest budget .", "sentence_id": 1}
+{"abstract_id": "25311746", "label": "methods", "text": "VQI prospectively collects data on many vascular procedures .", "sentence_id": 2}
+{"abstract_id": "25311746", "label": "methods", "text": "These data include many important perioperative , intraoperative , and postoperative details regarding both patients and their procedures .", "sentence_id": 3}
+{"abstract_id": "25311746", "label": "methods", "text": "We describe a study where minimal changes to the collected data by participating centers can provide level-@ evidence regarding a significant clinical question .", "sentence_id": 4}
+{"abstract_id": "25311746", "label": "methods", "text": "Data will be collected using modified VQI forms within the existing VQI data reporting structure .", "sentence_id": 5}
+{"abstract_id": "25311746", "label": "methods", "text": "We plan to enroll @ patients with asymptomatic PAAs into the open and endovascular surgery cohorts .", "sentence_id": 6}
+{"abstract_id": "25311746", "label": "methods", "text": "Patients from participating VQI centers will be randomized @:@ to either OPAR or EPAR and will be followed for an average of @ years .", "sentence_id": 7}
+{"abstract_id": "25311746", "label": "methods", "text": "Our primary hypothesis is that major adverse limb event-free survival is lower in the EPAR cohort and that EPAR is associated with more secondary interventions , improved quality of life , and decreased length of stay .", "sentence_id": 8}
+{"abstract_id": "25311746", "label": "methods", "text": "The budget for this trial is fixed at $ @,@ / year for the course of the study , and the trial is judged to be feasible because of the functionality of the VQI platform .", "sentence_id": 9}
+{"abstract_id": "25311746", "label": "conclusions", "text": "Using the existing VQI infrastructure , Open versus Endovascular Repair of Popliteal Artery Aneurysm will provide level @ data for PAA treatment on a modest budget .", "sentence_id": 10}
+{"abstract_id": "25311746", "label": "conclusions", "text": "The proposed trial has an adequately powered comparative design that will use objective performance goals to describe limb-related morbidity and procedural reintervention rates .", "sentence_id": 11}
+{"abstract_id": "26182736", "label": "background", "text": "Many minimally invasive interventional techniques as well as expectant treatment exist for the management of lower ureteric calculi .", "sentence_id": 0}
+{"abstract_id": "26182736", "label": "background", "text": "This study was conducted to evaluate th efficacy of tamsulosin as an expulsive pharmacologic therapy for the treatment of distal uretern stone .", "sentence_id": 1}
+{"abstract_id": "26182736", "label": "methods", "text": "This randomized control trial included @ patients over @ years of age wit stone Size > or = mm in distal @/@ of ureter .", "sentence_id": 2}
+{"abstract_id": "26182736", "label": "methods", "text": "Patients were randomly assigned into two groups ( A & B Group A Patients were given Capsule Tamsulosin @ mg , @ daily up to @ weeks while group B patients were given placebo , @ Capsule daily up to @ weeks .", "sentence_id": 3}
+{"abstract_id": "26182736", "label": "methods", "text": "The primary endpoint was expulsio rate .", "sentence_id": 4}
+{"abstract_id": "26182736", "label": "methods", "text": "A written informed consent was taken from all the patients .", "sentence_id": 5}
+{"abstract_id": "26182736", "label": "methods", "text": "Expulsion time , need for analgesics , need for hospitalization and drug side effects were secondary endpoints .", "sentence_id": 6}
+{"abstract_id": "26182736", "label": "results", "text": "A total of @ patients in group A and @ patients in group B reported back , therefore @ out of @ patients were evaluated .", "sentence_id": 7}
+{"abstract_id": "26182736", "label": "results", "text": "Mean age of the patients was @ years ( range @-@ years ) .", "sentence_id": 8}
+{"abstract_id": "26182736", "label": "results", "text": "Mea stone size was @ mm ( range @-@ mm ) in greatest dimension .", "sentence_id": 9}
+{"abstract_id": "26182736", "label": "results", "text": "A stone expulsion rate of @ C ( @ patients ) was noted in group A and @ % ( @ patients ) in group B. Group A revealed statistically significant advantage in term of stone expulsion rate ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "26182736", "label": "results", "text": "Considering expulsio time in days group A showed statistically significant advantage ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "26182736", "label": "results", "text": "Regarding age , se ) stone size and stone lateralization ( right/left ) , there was no significant difference between th group A and B. No drug side effects were noted in both the groups .", "sentence_id": 12}
+{"abstract_id": "26182736", "label": "conclusions", "text": "By usin tamsulosin a higher stone expulsion rates can be achieved in a shorter time .", "sentence_id": 13}
+{"abstract_id": "26182736", "label": "conclusions", "text": "More randomize control trials are required to establish tamsulosin as a standard medical expulsive treatment fc", "sentence_id": 14}
+{"abstract_id": "24880345", "label": "background", "text": "Despite improvements in liver surgery over the past decades , hemostasis during hepatic resections remains challenging .", "sentence_id": 0}
+{"abstract_id": "24880345", "label": "background", "text": "This multicenter randomized study compares the hemostatic effect of a collagen hemostat vs. a carrier-bound fibrin sealant after hepatic resection .", "sentence_id": 1}
+{"abstract_id": "24880345", "label": "methods", "text": "Patients scheduled for elective liver resection were randomized intraoperatively to receive either the collagen hemostat ( COLL ) or the carrier-bound fibrin sealant ( CBFS ) for secondary hemostasis .", "sentence_id": 2}
+{"abstract_id": "24880345", "label": "methods", "text": "The primary endpoint was the proportion of patients with hemostasis after @ min .", "sentence_id": 3}
+{"abstract_id": "24880345", "label": "methods", "text": "Secondary parameters were the proportions of patients with hemostasis after @ and @ min , the total time to hemostasis , and the complication rates during a @ months follow-up period .", "sentence_id": 4}
+{"abstract_id": "24880345", "label": "results", "text": "A total of @ patients were included .", "sentence_id": 5}
+{"abstract_id": "24880345", "label": "results", "text": "In the COLL group , @ out of @ patients ( @ % ) achieved complete hemostasis within @ min after application of the hemostat compared to @ out of @ patients ( @ % ) in the CBFS group .", "sentence_id": 6}
+{"abstract_id": "24880345", "label": "results", "text": "The @ % confidence interval for this difference -LSB- -@ % , @ % -RSB- does not include the lower noninferiority margin ( -@ % ) .", "sentence_id": 7}
+{"abstract_id": "24880345", "label": "results", "text": "Thus , the COLL treatment can be regarded as noninferior to the comparator .", "sentence_id": 8}
+{"abstract_id": "24880345", "label": "results", "text": "The proportions of patients with hemostasis after @ , @ , and @ min were not significantly different between the two study arms .", "sentence_id": 9}
+{"abstract_id": "24880345", "label": "results", "text": "Postoperative mortality and morbidity were similar in both treatment groups .", "sentence_id": 10}
+{"abstract_id": "24880345", "label": "conclusions", "text": "The collagen hemostat is as effective as the carrier-bound fibrin sealant in obtaining secondary hemostasis during liver resection with a comparable complication rate .", "sentence_id": 11}
+{"abstract_id": "24253758", "label": "objective", "text": "Several studies emphasise that arabinoxylan and - glucan have more beneficial effects on glucose metabolism than low-dietary fibre ( DF ) meals .", "sentence_id": 0}
+{"abstract_id": "24253758", "label": "objective", "text": "Less attention has been paid to the effects of concentrated DF compared with whole grain .", "sentence_id": 1}
+{"abstract_id": "24253758", "label": "objective", "text": "We compared the effects of DF and whole grain on glucose , hormone responses and appetite in subjects with the metabolic syndrome ( MetS ) .", "sentence_id": 2}
+{"abstract_id": "24253758", "label": "methods", "text": "Fifteen subjects with MetS participated in this acute , randomised , cross-over intervention study .", "sentence_id": 3}
+{"abstract_id": "24253758", "label": "methods", "text": "The test breads provided @ g of digestible carbohydrate : wheat bread with concentrated arabinoxylan ( AX ) or - glucan ( BG ) , rye bread with kernels ( RK ) and wheat bread ( WB ) as control .", "sentence_id": 4}
+{"abstract_id": "24253758", "label": "methods", "text": "Blood samples were drawn for @ min to determine glucose , insulin , glucagon-like peptide-@ , glucose-dependent insulinotropic peptide ( GIP ) and ghrelin .", "sentence_id": 5}
+{"abstract_id": "24253758", "label": "methods", "text": "Appetite score was addressed every @ min .", "sentence_id": 6}
+{"abstract_id": "24253758", "label": "methods", "text": "Ad libitum energy intake ( EI ) was measured @ min after test meals .", "sentence_id": 7}
+{"abstract_id": "24253758", "label": "results", "text": "Compared with WB , BG and RK induced lower initial glycaemic responses ( P < @ ) , whereas AX only reduced the glucose peak value ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24253758", "label": "results", "text": "RK reduced insulin ( P < @ ) and GIP responses ( P < @ ) compared with the other breads .", "sentence_id": 9}
+{"abstract_id": "24253758", "label": "results", "text": "BG lowered insulin responses more than AX ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24253758", "label": "results", "text": "AX , BG and RK increased satiety feeling ( P < @ ) more than WB , but did not differ significantly in terms of subsequent EI ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24253758", "label": "conclusions", "text": "BG and RK had beneficial impact on the glucose response , whereas AX had only effect on the postprandial glucose peak .", "sentence_id": 12}
+{"abstract_id": "24253758", "label": "conclusions", "text": "The impact of the AX bread was influenced by higher protein content .", "sentence_id": 13}
+{"abstract_id": "24253758", "label": "conclusions", "text": "Whether the metabolic effects of the breads are still present to mixed meals remains to be tested .", "sentence_id": 14}
+{"abstract_id": "24661511", "label": "objective", "text": "To evaluate the clinical effect of proton pump inhibitor-based triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori ( Hp ) infection among children in terms of Hp eradication rate and incidence of adverse events .", "sentence_id": 0}
+{"abstract_id": "24661511", "label": "methods", "text": "A prospective randomised controlled study was conducted on @ children with a confirmed diagnosis of Hp infection .", "sentence_id": 1}
+{"abstract_id": "24661511", "label": "methods", "text": "These patients were randomized into triple therapy ( n = @ ) and probiotics groups ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24661511", "label": "methods", "text": "The triple therapy group received amoxicillin -LSB- @mg / ( kgd ) , Tid -RSB- , clarithromycin -LSB- @mg / ( kgd ) , Bid -RSB- and omeprazole -LSB- @-@ @ mg / ( kgd ) , Qd -RSB- , while the probiotics group received Saccharomyces boulardii ( @mg , Bid ) in addition to triple therapy .", "sentence_id": 3}
+{"abstract_id": "24661511", "label": "methods", "text": "The course of treatment was @ days in both groups .", "sentence_id": 4}
+{"abstract_id": "24661511", "label": "methods", "text": "The adverse events in subjects were recorded by their parents during treatment .", "sentence_id": 5}
+{"abstract_id": "24661511", "label": "methods", "text": "Hp eradiation was evaluated by ( @ ) C breath test at @ weeks after treatment , and the eradication rate and incidence of adverse events were compared between the two groups .", "sentence_id": 6}
+{"abstract_id": "24661511", "label": "results", "text": "The Hp eradication rates were @ % ( @/@ ) in the triple therapy group and @ % ( @/@ ) in the probiotics group ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24661511", "label": "results", "text": "Compared with the triple therapy group , the probiotics group had nonsignificantly lower incidence of nausea , vomiting , and abdominal pain ( P > @ ) and significantly lower incidence of stomatitis , constipation and diarrhea ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24661511", "label": "conclusions", "text": "Triple therapy combined with Saccharomyces boulardii can not significantly increase Hp eradication rate , but can significantly reduce the incidence of stomatitis , constipation , and diarrhea during treatment .", "sentence_id": 9}
+{"abstract_id": "25186922", "label": "background", "text": "Little is known about the differences between standard-dose statins effects on glucose level and lipids in Japanese patients with diabetes mellitus ( DM ) .", "sentence_id": 0}
+{"abstract_id": "25186922", "label": "results", "text": "The @,@ patients were randomly assigned to either the rosuvastatin group or atorvastatin group .", "sentence_id": 1}
+{"abstract_id": "25186922", "label": "results", "text": "There were no significant differences between the @ groups in the effect on non-high-density lipoprotein cholesterol ( non-HDL-C ) and HbA@c at @ months .", "sentence_id": 2}
+{"abstract_id": "25186922", "label": "results", "text": "However , physicians tended to switch to more intensive therapy for DM in the atorvastatin group .", "sentence_id": 3}
+{"abstract_id": "25186922", "label": "conclusions", "text": "Rosuvastatin @ mg and atorvastatin @ mg have a similar lowering effect on non-HDL-C , but might be different in terms of adverse effect on glucose levels .", "sentence_id": 4}
+{"abstract_id": "24888929", "label": "objective", "text": "Oral feeding is likely to have an impact on early return of normal bowel function after uncomplicated surgery including cesarean section .", "sentence_id": 0}
+{"abstract_id": "24888929", "label": "objective", "text": "This study compared postoperative outcomes of early versus late oral feeding regimes after cesarean section .", "sentence_id": 1}
+{"abstract_id": "24888929", "label": "methods", "text": "In this clinical trial , @ pregnant women who underwent elective cesarean section with regional anesthesia were randomized into two feeding groups .", "sentence_id": 2}
+{"abstract_id": "24888929", "label": "methods", "text": "In the early oral and delayed oral feeding groups , liquid diets were commenced @ and @ h after surgery , respectively .", "sentence_id": 3}
+{"abstract_id": "24888929", "label": "methods", "text": "Patients able to tolerate the liquid diet were then gradually introduced to the regular diet .", "sentence_id": 4}
+{"abstract_id": "24888929", "label": "methods", "text": "Main clinical outcomes included duration of hospital stay , time to return of normal bowel function and postoperative gastrointestinal complications .", "sentence_id": 5}
+{"abstract_id": "24888929", "label": "results", "text": "Time to return of bowel movement ( @ @ vs @ @ h , P < @ ) and time to mobilization ( @ @ vs @ @ h , P = @ ) occurred significantly earlier in the early feeding group .", "sentence_id": 6}
+{"abstract_id": "24888929", "label": "conclusions", "text": "Early oral feeding reduces the time required for return of normal bowel function .", "sentence_id": 7}
+{"abstract_id": "24888929", "label": "conclusions", "text": "This is without significant detrimental effects on the incidence of gastrointestinal complications .", "sentence_id": 8}
+{"abstract_id": "25113132", "label": "background", "text": "Hepatitis C virus ( HCV ) infection is common among prisoners , particularly those with a history of injecting drug use ( IDU ) .", "sentence_id": 0}
+{"abstract_id": "25113132", "label": "background", "text": "Incarcerated people who inject drugs frequently report high-risk injecting practices both in prison and in the community .", "sentence_id": 1}
+{"abstract_id": "25113132", "label": "background", "text": "In spite of rising morbidity and mortality , utilisation of HCV-related services in Australia has been persistently low .", "sentence_id": 2}
+{"abstract_id": "25113132", "label": "background", "text": "This study aimed to describe the incidence , prevalence and correlates of HCV seropositivity in a large cohort of prisoners who have injected drugs , and to identify correlates of receiving confirmation of active infection .", "sentence_id": 3}
+{"abstract_id": "25113132", "label": "methods", "text": "Data-linkage to a State-wide statutory notifiable diseases surveillance system was used to investigate the incidence of notified HCV seropositivity , seroconversion and confirmed HCV infection in a cohort of @ prisoners with a history of IDU , over @ years of follow up .", "sentence_id": 4}
+{"abstract_id": "25113132", "label": "methods", "text": "Hepatitis C test results from prison medical records were used to identify correlates of testing positive in prison .", "sentence_id": 5}
+{"abstract_id": "25113132", "label": "results", "text": "The crude incidence of HCV notification was @ cases per @ person-years .", "sentence_id": 6}
+{"abstract_id": "25113132", "label": "results", "text": "By the end of follow up , @ % of the cohort had been the subject of a HCV-related notification , and @ % of those tested in prison were HCV seropositive .", "sentence_id": 7}
+{"abstract_id": "25113132", "label": "results", "text": "In multivariable analyses , injecting in prison was strongly associated with HCV seropositivity , as was opioid use compared to injection of other drugs .", "sentence_id": 8}
+{"abstract_id": "25113132", "label": "results", "text": "The rate of reported diagnostic confirmation among those with notified infections was very low , at @ confirmations per @ seropositive participants per year .", "sentence_id": 9}
+{"abstract_id": "25113132", "label": "conclusions", "text": "Injecting drugs in prison was strongly associated with HCV seropositivity , highlighting the need for increased provision of services to mitigate the risk of transmission within prisons .", "sentence_id": 10}
+{"abstract_id": "25113132", "label": "conclusions", "text": "Once identified as seropositive through screening , people with a history of IDU and incarceration may not be promptly receiving diagnostic services , which are necessary if they are to access treatment .", "sentence_id": 11}
+{"abstract_id": "25113132", "label": "conclusions", "text": "Improving access to HCV-related services will be of particular importance in the coming years , as HCV-related morbidity and mortality is increasing , and next generation therapies are becoming more widely available .", "sentence_id": 12}
+{"abstract_id": "24747867", "label": "objective", "text": "Data comparing the efficacy and safety of combination therapy with peginterferon plus low-dose ribavirin and peginterferon monotherapy in treatment-naive haemodialysis patients with hepatitis C virus genotype @ ( HCV-@ ) infection are limited .", "sentence_id": 0}
+{"abstract_id": "24747867", "label": "methods", "text": "In this randomised trial , @ patients received @weeks of peginterferon alfa-@a @g/week plus ribavirin @mg/day ( n = @ ) or peginterferon alfa-@a @g/week ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24747867", "label": "methods", "text": "The efficacy and safety endpoints were sustained virological response ( SVR ) rate and adverse event ( AE ) - related withdrawal rate .", "sentence_id": 2}
+{"abstract_id": "24747867", "label": "results", "text": "Compared with monotherapy , combination therapy had a greater SVR rate ( @ % vs @ % , relative risk ( RR ) : @ -LSB- @ % CI @ to @ -RSB- ; p < @ ) .", "sentence_id": 3}
+{"abstract_id": "24747867", "label": "results", "text": "The beneficial effect of combination therapy was more pronounced in patients with baseline viral load @,@ IU/mL than those with baseline viral load < @,@ IU/mL ( RR : @ -LSB- @ % CI @ to @ -RSB- vs. RR : @ -LSB- @ % CI @ to @ -RSB- ; interaction p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24747867", "label": "results", "text": "Patients receiving combination therapy were more likely to have a haemoglobin level of < @ g/dL ( @ % vs. @ % , risk difference ( RD ) : @ % -LSB- @ % CI @ % to @ % -RSB- ; p < @ ) and required a higher dosage -LSB- mean : @,@ vs. @ IU/week , p = @ -RSB- of epoetin to manage anaemia than those receiving monotherapy .", "sentence_id": 5}
+{"abstract_id": "24747867", "label": "results", "text": "The AE-related withdrawal rates were @ % and @ % in combination therapy and monotherapy groups , respectively ( RD : @ % -LSB- @ % CI -@ % to @ % -RSB- ) .", "sentence_id": 6}
+{"abstract_id": "24747867", "label": "conclusions", "text": "In treatment-naive haemodialysis patients with HCV-@ infection , combination therapy with peginterferon plus low-dose ribavirin achieved a greater SVR rate than peginterferon monotherapy .", "sentence_id": 7}
+{"abstract_id": "24747867", "label": "conclusions", "text": "Most haemodialysis patients can tolerate combination therapy .", "sentence_id": 8}
+{"abstract_id": "24661672", "label": "objective", "text": "The secreted protein acidic and rich in cysteine-like @ ( SPARCL@ ) is expressed in various normal tissues and many types of cancers .", "sentence_id": 0}
+{"abstract_id": "24661672", "label": "objective", "text": "The function of SPARCL@ and its relationship to a patient 's prognosis have been studied , whereas its relationship to radiation therapy ( RT ) is not known .", "sentence_id": 1}
+{"abstract_id": "24661672", "label": "objective", "text": "Our aim was to investigate the expression of SPARCL@ in rectal cancer patients who participated in a clinical trial of preoperative RT. .", "sentence_id": 2}
+{"abstract_id": "24661672", "label": "methods", "text": "The study included @ rectal cancer patients who were randomized to undergo preoperative RT and surgery ( n = @ ) or surgery alone ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24661672", "label": "methods", "text": "The expression levels of SPARCL@ in normal mucosa ( n = @ ) , primary tumor ( n = @ ) , and lymph node metastasis ( n = @ ) were determined by immunohistochemistry .", "sentence_id": 4}
+{"abstract_id": "24661672", "label": "results", "text": "Tumors with RT had stronger SPARCL@ expression than tumors without RT ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24661672", "label": "results", "text": "In the RT group , strong SPARCL@ expression was related to better survival than weak expression in patients with stage III tumors , independent of sex , age , differentiation , and margin status ( P = @ ; RR = @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24661672", "label": "results", "text": "No such relationship was found in the non-RT group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24661672", "label": "results", "text": "Further analysis of interactions among SPARCL@ expression , RT , and survival showed statistical significance ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24661672", "label": "results", "text": "In patients with metastases who received RT , strong SPARCL@ expression was related to better survival compared to weak expression ( P = @ ) but not in the non-RT group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24661672", "label": "conclusions", "text": "SPARCL@ expression increases with RT and is related to better prognosis in rectal cancer patients with RT but not in patients without RT. .", "sentence_id": 10}
+{"abstract_id": "24661672", "label": "conclusions", "text": "This result may help us to select the patients best suited for preoperative RT. .", "sentence_id": 11}
+{"abstract_id": "25168034", "label": "background", "text": "Relatively few treatment programs have been developed specifically for smokeless tobacco ( ST ) users who want to quit .", "sentence_id": 0}
+{"abstract_id": "25168034", "label": "background", "text": "Their results suggest that self-help materials , telephone counseling , and nicotine lozenges are efficacious .", "sentence_id": 1}
+{"abstract_id": "25168034", "label": "background", "text": "This study provides the first direct examination of the separate and combined effects of telephone counseling and lozenges .", "sentence_id": 2}
+{"abstract_id": "25168034", "label": "methods", "text": "We recruited ST users online ( N = @ ) and randomly assigned them to @ of @ conditions : ( a ) a lozenge group ( n = @ ) , who were mailed @-mg nicotine lozenges ; ( b ) a coach calls group ( n = @ ) , who were offered @ coaching phone calls ; or ( c ) a lozenge + coach calls group ( N = @ ) , who received both lozenges and coaching calls .", "sentence_id": 3}
+{"abstract_id": "25168034", "label": "methods", "text": "Additionally , all participants were mailed self-help materials .", "sentence_id": 4}
+{"abstract_id": "25168034", "label": "methods", "text": "Self-reported tobacco abstinence was assessed at @ and @ months after randomization .", "sentence_id": 5}
+{"abstract_id": "25168034", "label": "results", "text": "Complete-case and intention-to-treat ( ITT ) analyses for all tobacco abstinence were performed at @ months , @ months , and both @ and @ months ( repeated point prevalence ) .", "sentence_id": 6}
+{"abstract_id": "25168034", "label": "results", "text": "ITT analyses revealed a highly similar result : the lozenge + coach calls condition was significantly more successful in encouraging tobacco abstinence than either the lozenge group or the coach calls group , which did not differ .", "sentence_id": 7}
+{"abstract_id": "25168034", "label": "conclusions", "text": "Combining nicotine lozenges and phone counseling significantly increased tobacco abstinence rates compared with either intervention alone , whereas coach calls and lozenges were equivalent .", "sentence_id": 8}
+{"abstract_id": "25168034", "label": "conclusions", "text": "The study confirms the high tobacco abstinence rates for self-help ST cessation interventions and offers guidance to providing tobacco treatment to ST users .", "sentence_id": 9}
+{"abstract_id": "26079800", "label": "background", "text": "The authors conducted a randomized , controlled , parallel-arm , superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty .", "sentence_id": 0}
+{"abstract_id": "26079800", "label": "methods", "text": "Subjects undergoing tricompartment knee arthroplasty were randomized using computer-generated lists to either an adductor canal or femoral perineural catheter ( @-day ropivacaine @ % infusion ) in an unmasked manner .", "sentence_id": 1}
+{"abstract_id": "26079800", "label": "methods", "text": "The primary outcome was the time to attain four criteria : ( @ ) adequate analgesia ; ( @ ) intravenous opioids independence ; ( @ ) ability to stand , walk @ m , return , and sit down ; and ( @ ) ambulate @ m.", "sentence_id": 2}
+{"abstract_id": "26079800", "label": "results", "text": "Subjects with an adductor canal catheter ( n = @ ) reached all four criteria in a median of @h ( interquartile , @ to @h ) compared with @h ( @ to @h ) for those with a femoral catheter ( n = @ ; @ % CI , -@ to @h ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "26079800", "label": "results", "text": "The percentage of subjects who reached the two mobilization criteria on postoperative days @ and @ were @ and @ % for those with an adductor canal catheter ( n = @ ) , but only @ and @ % in subjects with a femoral catheter ( n = @ ; both P < @ ) .", "sentence_id": 4}
+{"abstract_id": "26079800", "label": "results", "text": "Differences in pain scores at rest and intravenous opioid requirements were minimal , but femoral infusion improved dynamic analgesia ( P = @ to @ ) .", "sentence_id": 5}
+{"abstract_id": "26079800", "label": "conclusions", "text": "Compared with a continuous femoral nerve block , a continuous adductor canal block did not appreciably decrease the time to overall discharge readiness even though it did decrease the time until adequate mobilization , primarily because both groups experienced similar analgesia and intravenous opioid requirements that -- in most cases -- exceeded the time to mobilization .", "sentence_id": 6}
+{"abstract_id": "24535654", "label": "background", "text": "To our knowledge , only a few double-blind randomized controlled trials with antipsychotic drugs have been conducted to examine the treatment of methamphetamine-induced psychosis ( MAP ) .", "sentence_id": 0}
+{"abstract_id": "24535654", "label": "objective", "text": "The aims of this study are to compare the antipsychotic and adverse events of quetiapine , an atypical antipsychotic drug , to haloperidol , a standard treatment for primary psychotic disorder , in individuals with MAP .", "sentence_id": 1}
+{"abstract_id": "24535654", "label": "methods", "text": "Eighty individuals with MAP were randomly assigned into two groups , i.e. treatment with quetiapine ( n = @ ) and haloperidol ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24535654", "label": "methods", "text": "Sixty-eight patients ( @ % ) completed the study protocol , i.e. treatment with quetiapine at least @ mg per day or haloperidol at least @ mg per day orally once a day for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24535654", "label": "methods", "text": "The doses were increased every @ days until no psychotic symptom was observed from the Positive and Negative Syndrome Scale ( PANSS ) .", "sentence_id": 4}
+{"abstract_id": "24535654", "label": "methods", "text": "Data were analysed by survival analysis with Cox 's proportional regression analysis , general estimating equations and log-rank tests .", "sentence_id": 5}
+{"abstract_id": "24535654", "label": "results", "text": "Thirty-two ( @ % ) subjects from the quetiapine group and @ subjects ( @ % ) from the haloperidol group met the remission criteria at the end of the study .", "sentence_id": 6}
+{"abstract_id": "24535654", "label": "results", "text": "Baseline PANSS total scores of quetiapine and haloperidol groups were @ @ and @ @ , respectively ( mean SD ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24535654", "label": "results", "text": "The change-from-baseline scores were -@ for the quetiapine group and -@ for the haloperidol group .", "sentence_id": 8}
+{"abstract_id": "24535654", "label": "results", "text": "There were no significant differences between the antipsychotic effects ( coefficient value = -@ , p = @ , @ % CI = -@ , @ ) and the adverse effects of quetiapine and haloperidol .", "sentence_id": 9}
+{"abstract_id": "24535654", "label": "conclusions", "text": "Quetiapine may be used as an antipsychotic treatment for MAP with comparable therapeutic effects and adverse events to treatment with classical antipsychotic drugs .", "sentence_id": 10}
+{"abstract_id": "24433609", "label": "background", "text": "Despite the important role that health professionals have in reducing tobacco use , many have a smoking habit themselves .", "sentence_id": 0}
+{"abstract_id": "24433609", "label": "background", "text": "The prevalence of smoking is particularly high among nurses .", "sentence_id": 1}
+{"abstract_id": "24433609", "label": "objective", "text": "To test the efficacy , acceptability and feasibility of a motivational interviewing ( MI ) based smoking cessation intervention with nurses .", "sentence_id": 2}
+{"abstract_id": "24433609", "label": "methods", "text": "Two group parallel experimental design with random allocation to groups .", "sentence_id": 3}
+{"abstract_id": "24433609", "label": "methods", "text": "A large teaching hospital in the North of Spain .", "sentence_id": 4}
+{"abstract_id": "24433609", "label": "methods", "text": "Nurses who smoked ( n = @ ) were randomised into two groups : motivational interviewing based intervention ( n = @ ) and usual care ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24433609", "label": "methods", "text": "Motivational interviewing based intervention consisted of four individual MI sessions .", "sentence_id": 6}
+{"abstract_id": "24433609", "label": "methods", "text": "Usual care consisted of brief advice .", "sentence_id": 7}
+{"abstract_id": "24433609", "label": "methods", "text": "Variables considered to assess efficacy were biochemically verified smoking cessation , mean cigarettes smoked , stages of change , self-efficacy and depression score .", "sentence_id": 8}
+{"abstract_id": "24433609", "label": "methods", "text": "Variables to assess acceptability and feasibility included participant satisfaction , adherence to MI , and duration of sessions .", "sentence_id": 9}
+{"abstract_id": "24433609", "label": "methods", "text": "Data were collected at : baseline , end of intervention and three months after the end of the intervention .", "sentence_id": 10}
+{"abstract_id": "24433609", "label": "results", "text": "At three month follow up , compared with the control group , more nurses in the intervention group had quit ( absolute difference @ % ; @ % confidence interval -LSB- CI -RSB- @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24433609", "label": "results", "text": "In the nurses who did not quit , there was no significant difference between the intervention and control groups in the number of cigarettes smoked per day , although progress in the stages of change was greater in the intervention group compared to the control group .", "sentence_id": 12}
+{"abstract_id": "24433609", "label": "results", "text": "Measures of acceptability and feasibility indicated good satisfaction with the intervention , with high levels of attendance and completion .", "sentence_id": 13}
+{"abstract_id": "24433609", "label": "conclusions", "text": "This study found a beneficial effect of motivational interviewing on nurses ' smoking cessation .", "sentence_id": 14}
+{"abstract_id": "24433609", "label": "conclusions", "text": "The intervention was acceptable for nurses and a number of aspects were identified that need to be considered prior to conducting a larger scale in order to optimise the intervention .", "sentence_id": 15}
+{"abstract_id": "24433609", "label": "conclusions", "text": "Using MI might be a novel approach to the problem of health professionals who smoke .", "sentence_id": 16}
+{"abstract_id": "24787302", "label": "background", "text": "The traditional treatment after closed reduction of distal radius ( DR ) and distal both bone ( DBB ) forearm fractures has been application of a long-arm cast ( LAC ) or a short-arm cast ( SAC ) .", "sentence_id": 0}
+{"abstract_id": "24787302", "label": "background", "text": "Splinting is another option that avoids the potential complications associated with casting .", "sentence_id": 1}
+{"abstract_id": "24787302", "label": "background", "text": "The purpose of this study is to evaluate the maintenance of reduction of DR or DBB fractures placed in a double-sugar-tong splint ( DSTS ) compared with a LAC in a pediatric population .", "sentence_id": 2}
+{"abstract_id": "24787302", "label": "methods", "text": "This is an IRB-approved , prospective , randomized trial .", "sentence_id": 3}
+{"abstract_id": "24787302", "label": "methods", "text": "Patients aged @ to @ years with DR or DBB fractures treated at a single institution between @ and @ were enrolled .", "sentence_id": 4}
+{"abstract_id": "24787302", "label": "methods", "text": "After reduction , fractures were placed into either a LAC or a DSTS .", "sentence_id": 5}
+{"abstract_id": "24787302", "label": "methods", "text": "Radiographs were reviewed at initial injury , postreduction , and at set intervals for angulation , displacement , and apposition , as well as cast index and @-point index .", "sentence_id": 6}
+{"abstract_id": "24787302", "label": "methods", "text": "The DSTS was overwrapped into a cast after week @ .", "sentence_id": 7}
+{"abstract_id": "24787302", "label": "methods", "text": "The immobilization device was changed to a SAC at week @ or @ .", "sentence_id": 8}
+{"abstract_id": "24787302", "label": "methods", "text": "Total duration of immobilization was @ to @ weeks .", "sentence_id": 9}
+{"abstract_id": "24787302", "label": "results", "text": "Seventy-one patients were enrolled with @ in the LAC and @ in the DSTS .", "sentence_id": 10}
+{"abstract_id": "24787302", "label": "results", "text": "Average age was @ years ( range , @ to @ ) with @ being males .", "sentence_id": 11}
+{"abstract_id": "24787302", "label": "results", "text": "There were @ isolated DR and @ DBB fractures .", "sentence_id": 12}
+{"abstract_id": "24787302", "label": "results", "text": "There were no week-to-week differences between the @ groups in regards to sagittal alignment , coronal alignment , apposition , or displacement .", "sentence_id": 13}
+{"abstract_id": "24787302", "label": "results", "text": "Sagittal alignment at immediate postreduction and week @ showed that the DSTS was slightly better ( average @ vs. @ degrees , respectively , P = @ ) .", "sentence_id": 14}
+{"abstract_id": "24787302", "label": "results", "text": "For the entire treatment period there was an increased risk of loss of reduction of @ degrees in the LAC group versus the DSTS group ( @ patients vs. @ patients , respectively , P = @ ) , and of meeting the criteria for remanipulation ( @ patients vs. @ patients , respectively , P = @ ) .", "sentence_id": 15}
+{"abstract_id": "24787302", "label": "results", "text": "At cast removal , there was no difference between groups .", "sentence_id": 16}
+{"abstract_id": "24787302", "label": "conclusions", "text": "Although there were significant differences between the @ groups with regards to risk of reduction loss , the DSTS and LAC were comparable in maintenance of reduction at the time of cast removal .", "sentence_id": 17}
+{"abstract_id": "24787302", "label": "conclusions", "text": "Both the DSTS and LAC are appropriate immobilization devices for these pediatric fractures .", "sentence_id": 18}
+{"abstract_id": "24787302", "label": "methods", "text": "Level II-prospective , comparative study .", "sentence_id": 19}
+{"abstract_id": "25459392", "label": "background", "text": "Pancreatic ductal adenocarcinoma ( PDAC ) is one of the most common malignant tumours and is still associated with a poor prognosis in advanced disease .", "sentence_id": 0}
+{"abstract_id": "25459392", "label": "background", "text": "To improve the standard therapy with gemcitabine , we initiated a prospective randomised phase-II trial with gemcitabine ( GEM ) versus gemcitabine plus sunitinib ( SUNGEM ) based on data of in vitro trials and phase-I data for the combination treatment .", "sentence_id": 1}
+{"abstract_id": "25459392", "label": "background", "text": "The rational of adding sunitinib was its putative antiangiogenic mechanism of action .", "sentence_id": 2}
+{"abstract_id": "25459392", "label": "methods", "text": "A total of @ eligible patients with locally advanced , unresectable or metastatic PDAC without previous system therapy were randomised to receive GEM at a dosage of @ mg/m ( @ ) d@ , @ , @ q@ versus a combination of SUNGEM at a dosage of GEM @ mg/m ( @ ) d@ +@ and sunitinib @mg p.o. d@-@ , q@d .", "sentence_id": 3}
+{"abstract_id": "25459392", "label": "methods", "text": "The primary end-point was progression free survival ( PFS ) , secondary end-points were overall survival ( OS ) , toxicity and overall response rate ( ORR ) .", "sentence_id": 4}
+{"abstract_id": "25459392", "label": "results", "text": "The confirmatory analysis of PFS was based on the intend-to-treat ( ITT ) population ( N = @ ) .", "sentence_id": 5}
+{"abstract_id": "25459392", "label": "results", "text": "The median PFS was @ weeks ( @ % confidence interval ( @ % - CI ) : @-@ @ weeks ) for GEM and @ weeks for SUNGEM ( @ % - CI : @-@ @ weeks ; p = @ one-sided log-rank ) .", "sentence_id": 6}
+{"abstract_id": "25459392", "label": "results", "text": "The ORR was @ % ( @ % - CI : @-@ @ % ) for GEM and for @ % ( @ % - CI : @-@ @ % ) for SUNGEM ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25459392", "label": "results", "text": "The median time to progression ( TTP ) was @ weeks ( @ % - CI : @-@ @ weeks ) for GEM and @ weeks ( @ % - CI : @-@ @ weeks ) for SUNGEM ( p = @ ; two-sided log-rank ) .", "sentence_id": 8}
+{"abstract_id": "25459392", "label": "results", "text": "The median OS was @ weeks ( @ % - CI : @-@ @ weeks ) for the GEM arm and @ weeks ( @ % - CI : @-@ @ weeks ) for the SUNGEM ( p = @ , one-sided log-rank ) .", "sentence_id": 9}
+{"abstract_id": "25459392", "label": "results", "text": "In regard to toxicities , suspected SAEs were reported in @ % in the GEM arm and @ % in the SUNGEM arm .", "sentence_id": 10}
+{"abstract_id": "25459392", "label": "results", "text": "Grade @ and @ neutropenia was statistically significantly higher in the SUNGEM arm with @ % versus @ % in the GEM arm ( p = @ , two sided log-rank ) .", "sentence_id": 11}
+{"abstract_id": "25459392", "label": "conclusions", "text": "The combination SUNGEM was not sufficient superior in locally advanced or metastatic PDAC compared to GEM alone in regard to efficacy but was associated with more toxicity .", "sentence_id": 12}
+{"abstract_id": "24427279", "label": "background", "text": "DHA is accumulated in the central nervous system ( CNS ) before birth and is involved in early developmental processes , such as neurite outgrowth and gene expression .", "sentence_id": 0}
+{"abstract_id": "24427279", "label": "objective", "text": "To determine whether fetal DHA insufficiency occurs and constrains CNS development in term gestation infants .", "sentence_id": 1}
+{"abstract_id": "24427279", "label": "methods", "text": "A risk reduction model using a randomized prospective study of term gestation single birth healthy infants born to women ( n = @ ) given a placebo or @ mg/day DHA from @ wk gestation to delivery .", "sentence_id": 2}
+{"abstract_id": "24427279", "label": "methods", "text": "Fetal DHA deficiency sufficient to constrain CNS development was assessed based on increased risk that infants in the placebo group would not achieve neurodevelopment scores in the top quartile of all infants in the study .", "sentence_id": 3}
+{"abstract_id": "24427279", "label": "results", "text": "Infants in the placebo group were at increased risk of lower language development assessed as words understood ( OR @ , CL @-@ @ , P = @ ) and produced ( OR @ , CL @-@ @ , P = @ ) at @ mo , and words understood ( OR @ , CL @-@ @ , P = @ ) and sentences produced ( OR @ , CL @-@ @ , P = @ ) at @ mo using the McArthur Communicative Developmental Inventory ; receptive ( OR @ , CL @-@ @ , P = @ ) and expressive language ( OR @ , CL @-@ @ , P = @ ) at @ mo using the Bayley Scales of Infant Development III ; and visual acuity ( OR @ , CL @-@ @ , P = @ ) at @ mo. .", "sentence_id": 4}
+{"abstract_id": "24886786", "label": "background", "text": "Although screening , brief intervention , and referral to treatment ( SBIRT ) has shown promise for alcohol use , relatively little is known about its effectiveness for adult illicit drug use .", "sentence_id": 0}
+{"abstract_id": "24886786", "label": "background", "text": "This randomized controlled trial assessed the effectiveness of the SBIRT approach for outcomes related to drug use among patients visiting trauma and emergency departments ( EDs ) at two large , urban hospitals .", "sentence_id": 1}
+{"abstract_id": "24886786", "label": "methods", "text": "A total of @ ED patients who admitted using illegal drugs in the past @days were recruited , consented , provided baseline measures of substance use and related problems measured with the Addiction Severity Index-Lite ( ASI-Lite ) , and then randomized to the Life Shift SBIRT intervention or to an attention-placebo control group focusing on driving and traffic safety ( Shift Gears ) .", "sentence_id": 2}
+{"abstract_id": "24886786", "label": "methods", "text": "Both groups received a level of motivational intervention matched to their condition and risk level by trained paraprofessional health educators .", "sentence_id": 3}
+{"abstract_id": "24886786", "label": "methods", "text": "Separate measurement technicians conducted face-to-face follow-ups at @months post-intervention and collected hair samples to confirm reports of abstinence from drug use .", "sentence_id": 4}
+{"abstract_id": "24886786", "label": "methods", "text": "The primary outcome measure of the study was past @-day drug abstinence at @months post-intervention , as self-reported on the ASI-Lite .", "sentence_id": 5}
+{"abstract_id": "24886786", "label": "results", "text": "Of @ participants , @ ( @ % ) completed follow-up .", "sentence_id": 6}
+{"abstract_id": "24886786", "label": "results", "text": "There were no significant differences in self-reported abstinence ( @ % vs. @ % , p = @ ) for Life Shift and Shift Gears groups , respectively .", "sentence_id": 7}
+{"abstract_id": "24886786", "label": "results", "text": "When results of hair analyses were applied , the abstinence rate was @ percent for Life Shift and @ percent for Shift Gears ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24886786", "label": "results", "text": "In an analysis in which results were imputed ( n = @ ) , there was no significant difference in the ASI-Lite drug use composite scores ( Life Shift +@ vs. Shift Gears +@ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24886786", "label": "conclusions", "text": "In this randomized controlled trial , there was no evidence of effectiveness of SBIRT on the primary drug use outcome .", "sentence_id": 10}
+{"abstract_id": "25544955", "label": "objective", "text": "This study aimed to compare the effects of different local anesthetic solutions on postoperative pain of anal surgery in adult patients .", "sentence_id": 0}
+{"abstract_id": "25544955", "label": "methods", "text": "In this randomized double-blind prospective clinical trial , @ adult patients ( @ to @ years old ) with physical status class I and class II that had been brought to a university hospital operating room for fistula anal surgery with spinal anesthesia were selected .", "sentence_id": 1}
+{"abstract_id": "25544955", "label": "methods", "text": "Patients were randomly divided into @ equal groups according to table of random numbers ( created by Random Allocation Software @ ) .", "sentence_id": 2}
+{"abstract_id": "25544955", "label": "methods", "text": "Group @ received @ mL of normal saline , group @ , @ mL of normal saline plus @ mL of bupivacaine @ % , group @ , @ mL of ketamine plus @ mL of bupivacaine @ % , and group @ , no infiltration .", "sentence_id": 3}
+{"abstract_id": "25544955", "label": "methods", "text": "Intensity of pain in patients was measured using visual analogue scale ( VAS ) at @ ( transfer to ward ) , @ , @ , @ , and @ hours after surgery .", "sentence_id": 4}
+{"abstract_id": "25544955", "label": "methods", "text": "Time interval to administration of drugs and overall dose of drugs were measured in @ groups .", "sentence_id": 5}
+{"abstract_id": "25544955", "label": "results", "text": "Mean level of pain was the lowest in group @ at all occasions with a significant difference , followed by groups @ , @ , and lastly @ ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25544955", "label": "results", "text": "Furthermore , groups @ and @ compared to groups @ and @ had the least overall dose of analgesics and requested them the latest , with a significant difference ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25544955", "label": "conclusions", "text": "Local anesthesia ( @ mL of ketamine plus @ mL of bupivacaine @ % or @ mL of normal saline plus @ mL of bupivacaine @ % ) combined with spinal anesthesia reduces postoperative pain and leads to greater comfort in recovering patients .", "sentence_id": 8}
+{"abstract_id": "25481336", "label": "objective", "text": "This study investigated inter-rater agreement ( IRA ) among EEG experts for the identification of electrographic seizures and periodic discharges ( PDs ) in continuous ICU EEG recordings .", "sentence_id": 0}
+{"abstract_id": "25481336", "label": "methods", "text": "Eight board-certified EEG experts independently identified seizures and PDs in thirty @-h EEG segments which were selected from ICU EEG recordings collected from three medical centers .", "sentence_id": 1}
+{"abstract_id": "25481336", "label": "methods", "text": "IRA was compared between seizure and PD identifications , as well as among rater groups that have passed an ICU EEG Certification Test , developed by the Critical Care EEG Monitoring Research Consortium ( CCEMRC ) .", "sentence_id": 2}
+{"abstract_id": "25481336", "label": "results", "text": "Both kappa and event-based IRA statistics showed higher mean values in identification of seizures compared to PDs ( k = @ vs. @ ; p < @ ) .", "sentence_id": 3}
+{"abstract_id": "25481336", "label": "results", "text": "The group of rater pairs who had both passed the ICU EEG Certification Test had a significantly higher mean IRA in comparison to rater pairs in which neither had passed the test .", "sentence_id": 4}
+{"abstract_id": "25481336", "label": "conclusions", "text": "IRA among experts is significantly higher for identification of electrographic seizures compared to PDs .", "sentence_id": 5}
+{"abstract_id": "25481336", "label": "conclusions", "text": "Additional instruction , such as the training module and certification test developed by the CCEMRC , could enhance this IRA .", "sentence_id": 6}
+{"abstract_id": "25481336", "label": "conclusions", "text": "This study demonstrates more disagreement in the labeling of PDs in comparison to seizures .", "sentence_id": 7}
+{"abstract_id": "25481336", "label": "conclusions", "text": "This may be improved by education about standard EEG nomenclature .", "sentence_id": 8}
+{"abstract_id": "24494804", "label": "background", "text": "The aim of this study was to comparatively evaluate three different stabilization methods with regards to the amount of shrinkage in free gingival graft .", "sentence_id": 0}
+{"abstract_id": "24494804", "label": "methods", "text": "Forty-five patients were included in three study groups : where stabilization was achieved with conventional technique , cyanoacrylate or microsurgery .", "sentence_id": 1}
+{"abstract_id": "24494804", "label": "methods", "text": "In the conventional group standardized @-@ sutures were used .", "sentence_id": 2}
+{"abstract_id": "24494804", "label": "methods", "text": "In the microsurgery group grafts were stabilized with @-@ sutures and loupe .", "sentence_id": 3}
+{"abstract_id": "24494804", "label": "methods", "text": "In the third group , graft was stabilized with cyanoacrylate .", "sentence_id": 4}
+{"abstract_id": "24494804", "label": "methods", "text": "Keratinized tissue width , graft area , gingival recession were calculated by a specific software on standard photographs at baseline , @ - , @ - , @-month follow-ups .", "sentence_id": 5}
+{"abstract_id": "24494804", "label": "methods", "text": "Duration of surgery was also recorded .", "sentence_id": 6}
+{"abstract_id": "24494804", "label": "methods", "text": "Pain in recipient and donor sites was assessed using visual analogue scale within the first postoperative week .", "sentence_id": 7}
+{"abstract_id": "24494804", "label": "results", "text": "Change in keratinized tissue width was similar in the study groups at all times .", "sentence_id": 8}
+{"abstract_id": "24494804", "label": "results", "text": "Graft shrinkage was significantly less ( p < @ ) in the cyanoacrylate group than the other groups , whereas those in the conventional and microsurgery groups were similar .", "sentence_id": 9}
+{"abstract_id": "24494804", "label": "results", "text": "Significantly less pain in the recipient site was reported by the patients in the cyanoacrylate group ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24494804", "label": "results", "text": "Duration of surgery was significantly less in the cyanoacrylate group than the other groups ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "24494804", "label": "conclusions", "text": "Less graft shrinkage in the free gingival graft , together with shorter surgery time and less pain in the recipient site obtained in the cyanoacrylate group , suggest that cyanoacrylate may be considered as an alternative for stabilization of free gingival grafts .", "sentence_id": 12}
+{"abstract_id": "26001320", "label": "objective", "text": "ECAR ( Endovasculaire ou Chirurgie dans les Anvrysmes aorto-iliaques Rompus ) is a prospective multicentre randomized controlled trial including consecutive patients with ruptured aorto-iliac aneurysms ( rAIA ) eligible for treatment by either endovascular ( EVAR ) or open surgical repair ( OSR ) .", "sentence_id": 0}
+{"abstract_id": "26001320", "label": "objective", "text": "Inclusion criteria were hemodynamic stability and computed tomography scan demonstrating aorto-iliac rupture .", "sentence_id": 1}
+{"abstract_id": "26001320", "label": "methods", "text": "Randomization was done by week , synchronously in all centers .", "sentence_id": 2}
+{"abstract_id": "26001320", "label": "methods", "text": "The primary end point was @ day mortality .", "sentence_id": 3}
+{"abstract_id": "26001320", "label": "methods", "text": "Secondary end points were post-operative morbidity , length of stay in the intensive care unit ( ICU ) , amount of blood transfused ( units ) and @ month mortality .", "sentence_id": 4}
+{"abstract_id": "26001320", "label": "results", "text": "From January @ to January @ , @ patients ( @ men , @ women ; median age @ years ) were enrolled in @ centers : @ ( @ % ) in the EVAR group and @ ( @ % ) in the OSR group .", "sentence_id": 5}
+{"abstract_id": "26001320", "label": "results", "text": "The groups were similar in terms of age , sex , consciousness , systolic blood pressure , Hardman index , IGSII score , type of rupture , use of endoclamping balloon , and levels of troponin , creatinine , and hemoglobin .", "sentence_id": 6}
+{"abstract_id": "26001320", "label": "results", "text": "Delay to treatment was higher in the EVAR group ( @ vs. @ hours ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "26001320", "label": "results", "text": "Mortality at @ days and @ year were not different between the groups ( @ % in the EVAR group vs. @ % in the OSR group at @ days , and @ % vs. @ % , respectively , at @ year ) .", "sentence_id": 8}
+{"abstract_id": "26001320", "label": "results", "text": "Total respiratory support time was lower in the EVAR group than in the OSR group ( @ hours vs. @ hours ; p = @ ) , as were pulmonary complications ( @ % vs. @ % , respectively ; p = @ ) , total blood transfusion ( @ vs. @ , respectively ; p = @ ) , and duration of ICU stay ( @ days vs. @ days , respectively ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "26001320", "label": "conclusions", "text": "In this study , EVAR was found to be equal to OSR in terms of @ day and @ year mortality .", "sentence_id": 10}
+{"abstract_id": "26001320", "label": "conclusions", "text": "However , EVAR was associated with less severe complications and less consumption of hospital resources than OSR .", "sentence_id": 11}
+{"abstract_id": "24602409", "label": "background", "text": "Interferon ( IFN ) - therapy for chronic hepatitis C virus infection is frequently associated with depression .", "sentence_id": 0}
+{"abstract_id": "24602409", "label": "background", "text": "The routine prophylaxis with antidepressants might expose patients to adverse effects , hence , the need for alternative preventive interventions .", "sentence_id": 1}
+{"abstract_id": "24602409", "label": "background", "text": "Omega-@ polyunsaturated fatty acids are safe and effective essential nutritional compounds used for the treatment of depression , putatively through an anti-inflammatory action .", "sentence_id": 2}
+{"abstract_id": "24602409", "label": "background", "text": "In addition , lower erythrocyte levels of omega-@ polyunsaturated fatty acids have been associated with an increased risk of IFN-induced depression .", "sentence_id": 3}
+{"abstract_id": "24602409", "label": "methods", "text": "We conducted a @-week , double-blind , placebo-controlled trial comparing eicosapentaenoic acid ( EPA ) , docosahexaenoic acid ( DHA ) , and placebo for the prevention of IFN -- induced depression .", "sentence_id": 4}
+{"abstract_id": "24602409", "label": "methods", "text": "A total of @ patients consented to participate and were randomized to the study .", "sentence_id": 5}
+{"abstract_id": "24602409", "label": "methods", "text": "All of the patients completed the @-week trial ; @ participants were followed throughout the @ weeks of IFN - treatment and were included in the analysis .", "sentence_id": 6}
+{"abstract_id": "24602409", "label": "results", "text": "Compared with placebo , the incident rates of IFN -- induced depression were significantly lower in EPA-treated but not in DHA-treated patients ( @ % and @ % , respectively , versus @ % for placebo , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24602409", "label": "results", "text": "Both EPA and DHA significantly delayed the onset of IFN-induced depression ( week of onset : @ and @ , respectively , versus @ for placebo , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24602409", "label": "results", "text": "EPA and DHA were both well tolerated in this population .", "sentence_id": 9}
+{"abstract_id": "24602409", "label": "results", "text": "EPA treatment increased both EPA and DHA erythrocyte levels , but DHA only increased DHA erythrocyte levels .", "sentence_id": 10}
+{"abstract_id": "24602409", "label": "conclusions", "text": "EPA is effective in the prevention of depression in hepatitis C virus patients received IFN - therapy .", "sentence_id": 11}
+{"abstract_id": "24602409", "label": "conclusions", "text": "Our study confirms the notion that anti-inflammatory strategies are effective antidepressants in the context of depression associated with inflammation .", "sentence_id": 12}
+{"abstract_id": "25727586", "label": "background", "text": "Some children have residual amblyopia after treatment with atropine eyedrops for amblyopia due to strabismus and/or anisometropia .", "sentence_id": 0}
+{"abstract_id": "25727586", "label": "background", "text": "We conducted a randomized clinical trial to evaluate the effectiveness of augmenting the effect of atropine by changing the lens over the fellow eye to plano in children with residual amblyopia .", "sentence_id": 1}
+{"abstract_id": "25727586", "label": "methods", "text": "A total of @ children @ to < @ years of age ( mean , @ years ) with stable residual amblyopia ( range , @/@ to @/@ , mean @/@ ( +@ ) ) were enrolled after at least @ weeks of atropine treatment of the fellow eye .", "sentence_id": 2}
+{"abstract_id": "25727586", "label": "methods", "text": "Participants were randomly assigned to continuing weekend atropine alone or wearing a plano lens over the fellow eye ( while continuing atropine ) .", "sentence_id": 3}
+{"abstract_id": "25727586", "label": "methods", "text": "The primary outcome was assessed at @ weeks , and participants were followed until improvement ceased .", "sentence_id": 4}
+{"abstract_id": "25727586", "label": "results", "text": "At the @-week primary outcome visit , amblyopic-eye visual acuity had improved an average of @ lines with the plano lens and @ lines with atropine only ( difference adjusted for baseline visual acuity = + @ line ; @ % CI , -@ to +@ ) .", "sentence_id": 5}
+{"abstract_id": "25727586", "label": "results", "text": "At the primary outcome or later visit when the best-measured visual acuity was observed , the mean amblyopic-eye improvement from baseline was @ lines with the plano lens and @ lines with atropine only .", "sentence_id": 6}
+{"abstract_id": "25727586", "label": "conclusions", "text": "When amblyopic-eye visual acuity stops improving with atropine treatment , there may be a small benefit to augmenting atropine therapy with a plano lens over the fellow eye .", "sentence_id": 7}
+{"abstract_id": "25727586", "label": "conclusions", "text": "However , the effect was not statistically significant , and the large confidence interval raises the possibility of no benefit or a benefit larger than we observed .", "sentence_id": 8}
+{"abstract_id": "25727586", "label": "conclusions", "text": "A larger study would be necessary to get a more precise estimate of the treatment effect .", "sentence_id": 9}
+{"abstract_id": "24915914", "label": "objective", "text": "To assess the efficacy and safety of heated humidified high-flow nasal cannula ( HHHFNC ) ventilation compared with nasal continuous positive airway pressure ( NCPAP ) on prevention of extubation failure in the NICUs .", "sentence_id": 0}
+{"abstract_id": "24915914", "label": "methods", "text": "A prospective randomized , controlled un-blinded study was conducted in @ tertiary hospitals in Hebei Province from December @ , @ to May @ , @ .", "sentence_id": 1}
+{"abstract_id": "24915914", "label": "methods", "text": "Neonates were eligible for this study if they were admitted to the participating NICUs within @ days of postnatal age , and needed noninvasive respiratory support after a period of mechanical ventilation with an endotracheal tube .", "sentence_id": 2}
+{"abstract_id": "24915914", "label": "methods", "text": "Infants were randomly assigned to either HHHFNC or NCPAP group .", "sentence_id": 3}
+{"abstract_id": "24915914", "label": "methods", "text": "The primary outcome measures included : the incidence of extubation failure , bronchopulmonary dysplasia and the mortality before discharge .", "sentence_id": 4}
+{"abstract_id": "24915914", "label": "results", "text": "Among the @ cases included , @ were in the HHHFNC group , and @ were in the NCPAP group .", "sentence_id": 5}
+{"abstract_id": "24915914", "label": "results", "text": "There was no significant difference in gestational age , birth weight , and age at randomization , and male/female ratio between the two groups ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24915914", "label": "results", "text": "There were no significant differences between groups for days on ventilation , noninvasive respiratory support , oxygen requirement , hospital stay and time to full oral feedings ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24915914", "label": "results", "text": "The overall mortality of the studied population was @ % ( @/@ ) .", "sentence_id": 8}
+{"abstract_id": "24915914", "label": "results", "text": "The occurrence of extubation failure within @ days was @ % whereas @ % in very low birth weight infants .", "sentence_id": 9}
+{"abstract_id": "24915914", "label": "results", "text": "There was no significant difference in the extubation failure for HHHFNC ( @/@ , @ % ) versus NCPAP ( @/@ , @ % ) ( P > @ ) , or in mortality for HHHFNC ( @/@ , @ % ) versus NCPAP ( @/@ , @ % ) ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "24915914", "label": "results", "text": "No significant difference was found between the study groups in the occurrence of bronchopulmonary dysplasia ( BPD ) and most of severe adverse outcomes analyzed , including air leak syndrome and nasal trauma .", "sentence_id": 11}
+{"abstract_id": "24915914", "label": "results", "text": "The occurrence of abdominal distention during treatment was higher in NCPAP than HHHFNC group ( @ % vs. @ % , P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24915914", "label": "conclusions", "text": "Among infants @ d of postnatal age , HHHFNC appears to have efficacy and safety similar to those of NCPAP group when applied immediately post-extubation to prevent extubation failure .", "sentence_id": 13}
+{"abstract_id": "24915914", "label": "conclusions", "text": "Despite concerns on unmonitored pressure delivery during HHHFNC support , no increase of the occurrence of BPD , air leak syndrome or mortality was found .", "sentence_id": 14}
+{"abstract_id": "24561752", "label": "background", "text": "Randomized trials found that use of erythropoiesis-stimulating agents to target normal hematocrit ( Hct ) levels ( > @ % ) compared with @ % -@ % increases cardiovascular risk and mortality among chronic kidney disease patients .", "sentence_id": 0}
+{"abstract_id": "24561752", "label": "background", "text": "However , the effects of the most widely used Hct target in the past @ decades , @ % -@ % , have never been examined .", "sentence_id": 1}
+{"abstract_id": "24561752", "label": "objective", "text": "To compare the effects of @ Hct target strategies-@ @ % -@ % ( low ) and @ % -@ % ( mid ) in a high-risk population : elderly dialysis patients with significant comorbidities .", "sentence_id": 2}
+{"abstract_id": "24561752", "label": "methods", "text": "Observational data from the US Renal Data System were used to emulate a randomized trial in which patients were assigned to either Hct strategy .", "sentence_id": 3}
+{"abstract_id": "24561752", "label": "methods", "text": "Follow-up started after completing @ months of hemodialysis and ended @ months later .", "sentence_id": 4}
+{"abstract_id": "24561752", "label": "methods", "text": "We conducted the observational analogs of intention-to-treat and per-protocol analyses .", "sentence_id": 5}
+{"abstract_id": "24561752", "label": "methods", "text": "Inverse-probability weighting was used to adjust for measured time-dependent confounding by indication .", "sentence_id": 6}
+{"abstract_id": "24561752", "label": "methods", "text": "A total of @,@ elderly patients with both diabetes and cardiovascular disease who initiated hemodialysis in @-@ .", "sentence_id": 7}
+{"abstract_id": "24561752", "label": "methods", "text": "Hazard ratios ( HRs ) and survival probabilities for all-cause mortality and a composite cardiovascular and mortality endpoint .", "sentence_id": 8}
+{"abstract_id": "24561752", "label": "results", "text": "The intention-to-treat HR ( @ % confidence interval ) for mid versus low Hct strategy was @ ( @-@ @ ) for all-cause mortality and @ ( @-@ @ ) for the composite endpoint .", "sentence_id": 9}
+{"abstract_id": "24561752", "label": "results", "text": "The per-protocol HR ( @ % confidence interval ) for mid versus low Hct strategy was @ ( @-@ @ ) for all-cause mortality and @ ( @-@ @ ) for the composite outcome .", "sentence_id": 10}
+{"abstract_id": "24561752", "label": "conclusions", "text": "Among hemodialysis patients , we did not find differences in @-month survival or cardiovascular risk between clinical strategies that target Hct at @ % -@ % versus @ % -@ % .", "sentence_id": 11}
+{"abstract_id": "24885486", "label": "background", "text": "Few cancers pose greater challenges than head and neck ( H&N ) cancer .", "sentence_id": 0}
+{"abstract_id": "24885486", "label": "background", "text": "Residual effects following treatment include body image changes , pain , fatigue and difficulties with appetite , swallowing and speech .", "sentence_id": 1}
+{"abstract_id": "24885486", "label": "background", "text": "Depression is a common comorbidity .", "sentence_id": 2}
+{"abstract_id": "24885486", "label": "background", "text": "There is limited evidence about ways to assist patients to achieve optimal adjustment after completion of treatment .", "sentence_id": 3}
+{"abstract_id": "24885486", "label": "background", "text": "In this study , we aim to examine the effectiveness and feasibility of a model of survivorship care to improve the quality of life of patients who have completed treatment for H&N cancer .", "sentence_id": 4}
+{"abstract_id": "24885486", "label": "methods", "text": "This is a preliminary study in which @ patients will be recruited .", "sentence_id": 5}
+{"abstract_id": "24885486", "label": "methods", "text": "A prospective randomised controlled trial of the H&N Cancer Survivor Self-management Care Plan ( HNCP ) involving pre - and post-intervention assessments will be used .", "sentence_id": 6}
+{"abstract_id": "24885486", "label": "methods", "text": "Consecutive patients who have completed a defined treatment protocol for H&N cancer will be recruited from two large cancer services and randomly allocated to one of three study arms : ( @ ) usual care , ( @ ) information in the form of a written resource or ( @ ) the HNCP delivered by an oncology nurse who has participated in manual-based training and skill development in patient self-management support .", "sentence_id": 7}
+{"abstract_id": "24885486", "label": "methods", "text": "The trained nurses will meet patients in a face-to-face interview lasting up to @ minutes to develop an individualised HNCP , based on principles of chronic disease self-management .", "sentence_id": 8}
+{"abstract_id": "24885486", "label": "methods", "text": "Participants will be assessed at baseline , @ and @ months .", "sentence_id": 9}
+{"abstract_id": "24885486", "label": "methods", "text": "The primary outcome measure is quality of life .", "sentence_id": 10}
+{"abstract_id": "24885486", "label": "methods", "text": "The secondary outcome measures include mood , self-efficacy and health-care utilisation .", "sentence_id": 11}
+{"abstract_id": "24885486", "label": "methods", "text": "The feasibility of implementing this intervention in routine clinical care will be assessed through semistructured interviews with participating nurses , managers and administrators .", "sentence_id": 12}
+{"abstract_id": "24885486", "label": "methods", "text": "Interviews with patients who received the HNCP will explore their perceptions of the HNCP , including factors that assisted them in achieving behavioural change .", "sentence_id": 13}
+{"abstract_id": "24885486", "label": "conclusions", "text": "In this study , we aim to improve the quality of life of a patient population with unique needs by means of a tailored self-management care plan developed upon completion of treatment .", "sentence_id": 14}
+{"abstract_id": "24885486", "label": "conclusions", "text": "Delivery of the intervention by trained oncology nurses is likely to be acceptable to patients and , if successful , will be a model of care that can be implemented for diverse patient populations .", "sentence_id": 15}
+{"abstract_id": "25359924", "label": "background", "text": "Antiviral therapy with interferon-alpha ( IFN - ) for hepatitis C virus ( HCV ) infection is associated with increased risk for depression .", "sentence_id": 0}
+{"abstract_id": "25359924", "label": "objective", "text": "To identify clinical predictors for IFN -- induced depression during antiviral therapy for HCV infection .", "sentence_id": 1}
+{"abstract_id": "25359924", "label": "methods", "text": "Depression ( defined with the Montgomery-sberg Depression Rating Scale ( MADRS ) ) was evaluated before and during antiviral treatment in @ people with chronic HCV infection without a history of psychiatric disorders .", "sentence_id": 2}
+{"abstract_id": "25359924", "label": "methods", "text": "Cognitive function was evaluated using the Trail Making Test A/B ( TMT A/B ) .", "sentence_id": 3}
+{"abstract_id": "25359924", "label": "methods", "text": "( Trial registration at ClinicalTrials.gov : NCT@ . )", "sentence_id": 4}
+{"abstract_id": "25359924", "label": "results", "text": "Depression during antiviral therapy was significantly associated with a baseline MADRS score of @ or higher ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25359924", "label": "results", "text": "In total , @ % ( n = @ ) of patients who had a baseline score > @ for the single item sadness developed depression .", "sentence_id": 6}
+{"abstract_id": "25359924", "label": "results", "text": "Poor baseline performance in the TMT A ( P = @ ) and TMT B ( P = @ ) was predictive for severe depression .", "sentence_id": 7}
+{"abstract_id": "25359924", "label": "conclusions", "text": "Pre-treatment screening for subthreshold depressive and cognitive symptoms will help to identify those at risk for IFN -- associated depression among patients with chronic hepatitis C.", "sentence_id": 8}
+{"abstract_id": "25194996", "label": "objective", "text": "To study the effects of closure vs nonclosure of buccal mucosal graft harvest site .", "sentence_id": 0}
+{"abstract_id": "25194996", "label": "methods", "text": "Patients were randomized to either primary closure or nonclosure of buccal mucosal harvest site during urethroplasty .", "sentence_id": 1}
+{"abstract_id": "25194996", "label": "methods", "text": "Graft widths were standardized to @ cm .", "sentence_id": 2}
+{"abstract_id": "25194996", "label": "methods", "text": "Prospective data were collected via patient visual analog scales ( @-@ ) of @ domains examining pain , numbness , tightness , drinking , and eating at postoperative day @ and @ and then at @ weeks and @ months until @ year .", "sentence_id": 3}
+{"abstract_id": "25194996", "label": "results", "text": "There were @ patients who underwent randomization and completed the study .", "sentence_id": 4}
+{"abstract_id": "25194996", "label": "results", "text": "The preoperative demographics between both groups were comparable with no significant differences .", "sentence_id": 5}
+{"abstract_id": "25194996", "label": "results", "text": "The median age is @ years .", "sentence_id": 6}
+{"abstract_id": "25194996", "label": "results", "text": "There were @ patients in the closure group and @ patients in the nonclosure group .", "sentence_id": 7}
+{"abstract_id": "25194996", "label": "results", "text": "The results show an improvement in the domains of pain ( P = @ ) , drinking ( P = @ ) , and eating ( P = @ ) in favor of the closure group at postoperative day @ and @ .", "sentence_id": 8}
+{"abstract_id": "25194996", "label": "results", "text": "There are no significant differences in all @ domains between both groups after @ weeks postoperatively", "sentence_id": 9}
+{"abstract_id": "25194996", "label": "conclusions", "text": "This study shows that primary closure of buccal mucosal graft bed improves pain as well as oral intake in the immediate postoperative period .", "sentence_id": 10}
+{"abstract_id": "25194996", "label": "conclusions", "text": "There are no long-term differences .", "sentence_id": 11}
+{"abstract_id": "25271389", "label": "background", "text": "Uncertainty exists about the most effective route for delivery of early nutritional support in critically ill adults .", "sentence_id": 0}
+{"abstract_id": "25271389", "label": "background", "text": "We hypothesized that delivery through the parenteral route is superior to that through the enteral route .", "sentence_id": 1}
+{"abstract_id": "25271389", "label": "methods", "text": "We conducted a pragmatic , randomized trial involving adults with an unplanned admission to one of @ English intensive care units .", "sentence_id": 2}
+{"abstract_id": "25271389", "label": "methods", "text": "We randomly assigned patients who could be fed through either the parenteral or the enteral route to a delivery route , with nutritional support initiated within @ hours after admission and continued for up to @ days .", "sentence_id": 3}
+{"abstract_id": "25271389", "label": "methods", "text": "The primary outcome was all-cause mortality at @ days .", "sentence_id": 4}
+{"abstract_id": "25271389", "label": "results", "text": "We enrolled @ patients ; @ ( @ % ) were included in the analysis ( @ in the parenteral group and @ in the enteral group ) .", "sentence_id": 5}
+{"abstract_id": "25271389", "label": "results", "text": "By @ days , @ of @ patients ( @ % ) in the parenteral group and @ of @ patients ( @ % ) in the enteral group had died ( relative risk in parenteral group , @ ; @ % confidence interval , @ to @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25271389", "label": "results", "text": "There were significant reductions in the parenteral group , as compared with the enteral group , in rates of hypoglycemia ( @ patients -LSB- @ % -RSB- vs. @ patients -LSB- @ % -RSB- ; P = @ ) and vomiting ( @ patients -LSB- @ % -RSB- vs. @ patients -LSB- @ % -RSB- ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25271389", "label": "results", "text": "There were no significant differences between the parenteral group and the enteral group in the mean number of treated infectious complications ( @ vs. @ ; P = @ ) , @-day mortality ( @ of @ patients -LSB- @ % -RSB- vs. @ of @ patients -LSB- @ % -RSB- , P = @ ) , in rates of @ other secondary outcomes , or in rates of adverse events .", "sentence_id": 8}
+{"abstract_id": "25271389", "label": "results", "text": "Caloric intake was similar in the two groups , with the target intake not achieved in most patients .", "sentence_id": 9}
+{"abstract_id": "25271389", "label": "conclusions", "text": "We found no significant difference in @-day mortality associated with the route of delivery of early nutritional support in critically ill adults .", "sentence_id": 10}
+{"abstract_id": "25271389", "label": "conclusions", "text": "( Funded by the United Kingdom National Institute for Health Research ; CALORIES Current Controlled Trials number , ISRCTN@ . )", "sentence_id": 11}
+{"abstract_id": "24556911", "label": "objective", "text": "To evaluate the effect of the intravenous ( i.v. ) L-alanyl-L-glutamine dipeptide supplementation during @ days on clinical outcome in trauma patients admitted to the intensive care unit ( ICU ) .", "sentence_id": 0}
+{"abstract_id": "24556911", "label": "methods", "text": "This was a prospective , randomized , double-blind , multicenter trial .", "sentence_id": 1}
+{"abstract_id": "24556911", "label": "methods", "text": "Glutamine was not given as a component of nutrition but as an extra infusion .", "sentence_id": 2}
+{"abstract_id": "24556911", "label": "methods", "text": "The primary outcome variable was the number of new infections within the first @ days .", "sentence_id": 3}
+{"abstract_id": "24556911", "label": "results", "text": "We included @ patients .", "sentence_id": 4}
+{"abstract_id": "24556911", "label": "results", "text": "There were no differences between groups in baseline characteristics .", "sentence_id": 5}
+{"abstract_id": "24556911", "label": "results", "text": "Up to @ % of the patients in the placebo group and @ % in the treatment group presented confirmed infections ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24556911", "label": "results", "text": "ICU length of stay was @ days in both groups ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24556911", "label": "results", "text": "Hospital length of stay was @ days in the placebo group and @ in the treatment group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24556911", "label": "results", "text": "ICU mortality was @ % in both groups ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24556911", "label": "results", "text": "Sixty percent of the patients presented low glutamine levels before randomization .", "sentence_id": 10}
+{"abstract_id": "24556911", "label": "results", "text": "At the end of the treatment ( @th day ) , @ % of the patients maintained low glutamine levels ( @ % of treated patients vs. @ % in the placebo group ) .", "sentence_id": 11}
+{"abstract_id": "24556911", "label": "results", "text": "Patients with low glutamine levels at day @ had more number of infections ( @ vs. @ % ; p = @ ) and longer ICU ( @ vs. @ days ; p < @ ) and hospital length of stay ( @ vs. @ days ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24556911", "label": "conclusions", "text": "There was no benefit with i.v. L-alanyl-L-glutamine dipeptide supplementation ( @ g/kg body weight/day of the dipeptide ) during @ days in trauma patients admitted to the ICU .", "sentence_id": 13}
+{"abstract_id": "24556911", "label": "conclusions", "text": "The i.v. glutamine supplementation was not enough to normalize the plasma glutamine levels in all patients .", "sentence_id": 14}
+{"abstract_id": "24556911", "label": "conclusions", "text": "Low plasma glutamine levels at day @ were associated with a worse outcome .", "sentence_id": 15}
+{"abstract_id": "24708818", "label": "background", "text": "Dietary sodium restriction is a key management strategy in chronic kidney disease ( CKD ) .", "sentence_id": 0}
+{"abstract_id": "24708818", "label": "background", "text": "Recent evidence has demonstrated short-term reduction in blood pressure ( BP ) and proteinuria with sodium restriction , however the effect on other cardiovascular-related risk factors requires investigation in CKD .", "sentence_id": 1}
+{"abstract_id": "24708818", "label": "methods", "text": "The LowSALT CKD study involved @ hypertensive Stage III-IV CKD patients counselled by a dietitian to consume a low-sodium diet ( < @mmol/day ) .", "sentence_id": 2}
+{"abstract_id": "24708818", "label": "methods", "text": "The study was a randomised crossover trial comparing @weeks of high-sodium ( additional @mmol sodium tablets ) and low-sodium intake ( placebo ) .", "sentence_id": 3}
+{"abstract_id": "24708818", "label": "methods", "text": "Measurements were taken after each crossover arm including BP ( peripheral and central ) , adipokines ( inflammation markers and adiponectin ) , volume markers ( extracellular-to-intracellular -LSB- E/I -RSB- fluid ratio ; N-terminal pro-brain natriuretic peptide -LSB- NT-proBNP -RSB- ) , kidney function ( estimated Glomerular Filtration Rate -LSB- eGFR -RSB- ) and proteinuria ( urine protein-creatinine ratio -LSB- PCR -RSB- and albumin-creatinine ratio -LSB- ACR -RSB- ) .", "sentence_id": 4}
+{"abstract_id": "24708818", "label": "methods", "text": "Outcomes were compared using paired t-test for each cross-over arm .", "sentence_id": 5}
+{"abstract_id": "24708818", "label": "results", "text": "BP-lowering benefits of a low-sodium intake ( peripheral BP ( meanSD ) @/@/@mmHg ) from high-sodium ( @/@/@mmHg ) intake were reflected in central BP and a reduction in eGFR , PCR , ACR , NTproBNP and E/I ratio .", "sentence_id": 6}
+{"abstract_id": "24708818", "label": "results", "text": "There was no change in inflammatory markers , total or high molecular weight adiponectin .", "sentence_id": 7}
+{"abstract_id": "24708818", "label": "conclusions", "text": "Short-term benefits of sodium restriction on BP were reflected in significant change in kidney function and fluid volume parameters .", "sentence_id": 8}
+{"abstract_id": "24708818", "label": "conclusions", "text": "Larger , long-term adequately powered trials in CKD are necessary to confirm these results .", "sentence_id": 9}
+{"abstract_id": "24337884", "label": "background", "text": "Endoscopic submucosal dissection ( ESD ) is a standard treatment for gastric neoplasia limited to the mucosa without lymph node metastasis .", "sentence_id": 0}
+{"abstract_id": "24337884", "label": "background", "text": "However , there are neither standardized guidelines nor studies on the best time to start oral intake after ESD .", "sentence_id": 1}
+{"abstract_id": "24337884", "label": "background", "text": "The aim of this study was to compare patient satisfaction , safety , length of hospital stay , and economic feasibility between an early post-ESD diet and the conventional immediate fasting protocol .", "sentence_id": 2}
+{"abstract_id": "24337884", "label": "methods", "text": "A total of @ patients with @ gastric epithelial neoplasias who underwent ESD by a single expert endoscopist were consecutively and prospectively enrolled .", "sentence_id": 3}
+{"abstract_id": "24337884", "label": "methods", "text": "Enrolled patients were randomized to an early diet group or a control group .", "sentence_id": 4}
+{"abstract_id": "24337884", "label": "methods", "text": "The early diet group started meals as a clear liquid diet on day @ , and a soft diet and general diet in sequence on day @ .", "sentence_id": 5}
+{"abstract_id": "24337884", "label": "methods", "text": "The fasting group was fasted for @ days .", "sentence_id": 6}
+{"abstract_id": "24337884", "label": "methods", "text": "Patients in both groups underwent second-look endoscopy within @ days following ESD and follow-up endoscopy after @ months .", "sentence_id": 7}
+{"abstract_id": "24337884", "label": "results", "text": "In the course of the study , ten patients were excluded .", "sentence_id": 8}
+{"abstract_id": "24337884", "label": "results", "text": "The total number of patients in the early diet group and control group was @ and @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24337884", "label": "results", "text": "Mean age was @ years ( @ ) .", "sentence_id": 10}
+{"abstract_id": "24337884", "label": "results", "text": "There were no significant differences in clinicopathologic conditions or endoscopic results such as procedure time or size of lesions between the two groups .", "sentence_id": 11}
+{"abstract_id": "24337884", "label": "results", "text": "There were no significant differences in abdominal pain score , rate of post-ESD bleeding or healing rate of ESD-induced ulcer between the two groups .", "sentence_id": 12}
+{"abstract_id": "24337884", "label": "results", "text": "However , the early diet protocol led to significantly higher patient satisfaction ( p = @ ) , lower hospital costs ( p < @ ) , and shorter hospital stay ( p < @ ) than the conventional fasting protocol .", "sentence_id": 13}
+{"abstract_id": "24337884", "label": "conclusions", "text": "An early post-ESD diet protocol provides higher patient satisfaction , is more cost effective , decreases hospital stay , and does not influence complication rates such as post-ESD bleeding , abdominal pain , or ulcer healing compared with the conventional fasting protocol .", "sentence_id": 14}
+{"abstract_id": "25351025", "label": "background", "text": "Internet-based applications are becoming more common in our modern world .", "sentence_id": 0}
+{"abstract_id": "25351025", "label": "background", "text": "While electronic health records ( EHR ) are available for patients and health care providers outside of Germany , most of the available data on EHR address only monetary advantages.This study explores whether or not internet-based communication between family physicians ( FP ) and patients is as safe as traditional oral communication and if it may lead to further benefits .", "sentence_id": 1}
+{"abstract_id": "25351025", "label": "methods", "text": "@ patients from @ family doctors ' offices were included in this @ months RCT .", "sentence_id": 2}
+{"abstract_id": "25351025", "label": "methods", "text": "Both groups were treated in the same manner by their respective physicians , but members of the study group ( SG ) were able to access an individual developed web-based software where they could view their diagnosis and medication , and send an electronic message to their doctors who would respond .", "sentence_id": 3}
+{"abstract_id": "25351025", "label": "methods", "text": "Their satisfication with the FP , certain health data and the FP 's workload were recorded .", "sentence_id": 4}
+{"abstract_id": "25351025", "label": "results", "text": "a ) Patients ' satisfaction : When e.g. asked about the organization of the family practice or trust in the doctor , there were no significant differences between the control ( CG ) and the SG ( p = @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25351025", "label": "results", "text": "However , patients of the SG felt better informed ( p = @ ) , and generally more satisfied with their FP ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25351025", "label": "results", "text": "b ) FP workload : Members of the CG had @ contacts with their doctors during the study , while the SG only had @ recorded contacts ( including web-based contacts , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25351025", "label": "results", "text": "It took physicians @:@ minutes less to read and respond to an electronic message than to see a patient during the consultation hours .", "sentence_id": 8}
+{"abstract_id": "25351025", "label": "results", "text": "c ) Changes in patients ' health : During the study the blood pressure ( BP ) in the CG rose @ / @ mmHg , while it dropped @ / @ mmHg in the SG ( p = @ / @ ) .", "sentence_id": 9}
+{"abstract_id": "25351025", "label": "results", "text": "The HbA ( @C ) dropped in both groups ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25351025", "label": "results", "text": "One week after the first visit to the family doctor , patients of the SG rated their pain @ points lower on a VAS than the CG ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25351025", "label": "results", "text": "@ % from the CG and @ % from the SG requested the re-prescription of long-term medication on time ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25351025", "label": "conclusions", "text": "Using an optional web-based communication platform is as safe as traditional consultations can be .", "sentence_id": 13}
+{"abstract_id": "25351025", "label": "conclusions", "text": "Both patients and doctors may benefit from using the internet in this context .", "sentence_id": 14}
+{"abstract_id": "24472665", "label": "background", "text": "Many transfusion services are keeping thawed plasma ( TP ) ready for trauma patients .", "sentence_id": 0}
+{"abstract_id": "24472665", "label": "background", "text": "According to Chinese guidelines , once thawed , fresh frozen plasma ( FFP ) should be used within @h .", "sentence_id": 1}
+{"abstract_id": "24472665", "label": "background", "text": "This may increase plasma wastage and delay plasma administration to critical patients .", "sentence_id": 2}
+{"abstract_id": "24472665", "label": "background", "text": "However , it can be avoided by being relabeled as TP .", "sentence_id": 3}
+{"abstract_id": "24472665", "label": "background", "text": "In this study we evaluated coagulation-related proteins in thawed apheresis FFP during @ days of storage at @-@ C.", "sentence_id": 4}
+{"abstract_id": "24472665", "label": "methods", "text": "Thirty apheresis fresh plasma units were aliquot and stored at -@ C. Aliquots were thawed at @ C and stored at @-@ C for @ , @ , @ , @ , @ and @ days , respectively .", "sentence_id": 5}
+{"abstract_id": "24472665", "label": "methods", "text": "Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , thrombin time ( TT ) , fibrinogen ( Fbg ) , factor ( F ) II , FV , FVII , FVIII , FIX , FX , FXI , FXII , protein C ( PC ) , protein S ( PS ) , antithrombin III ( ATIII ) and ADAMTS@ levels were assessed at Days @-@ , respectively .", "sentence_id": 6}
+{"abstract_id": "24472665", "label": "results", "text": "For @ days of refrigerated storage , no significant differences were observed in Fbg , PC , PS , ATIII and ADAMTS@ .", "sentence_id": 7}
+{"abstract_id": "24472665", "label": "results", "text": "FII , FV , FVII , FVIII , FIX , FX , FXI and FXII declined significantly over time .", "sentence_id": 8}
+{"abstract_id": "24472665", "label": "results", "text": "The storage presented major decrease for FVIII , with a drop of @ % .", "sentence_id": 9}
+{"abstract_id": "24472665", "label": "results", "text": "However , at least @ % levels of all measured proteins were remained on Day @ , when compared to Day @ .", "sentence_id": 10}
+{"abstract_id": "24472665", "label": "conclusions", "text": "All measured proteins in TP for @ days of refrigerated storage were adequate .", "sentence_id": 11}
+{"abstract_id": "24472665", "label": "conclusions", "text": "These could provide evidence that thawed FFP could be relabeled as TP , which is a potential to ensure rapid plasma availability in emergency situations in China .", "sentence_id": 12}
+{"abstract_id": "26521576", "label": "objective", "text": "To explore the clinical efficacy and safety of acupuncture and moxibustion for copracrasia .", "sentence_id": 0}
+{"abstract_id": "26521576", "label": "methods", "text": "By prospective live randomized controlled trial , @ cases with copracrasia were randomly divided into an acupuncture-moxibustion group and a medication group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "26521576", "label": "methods", "text": "In the acupuncture-moxibustion group , acupuncture was applied at Ciliao ( BL @ ) , Changqiang ( GV @ ) and Tianshu ( ST @ ) and mild moxibustion was used at Qihai ( CV @ ) .", "sentence_id": 2}
+{"abstract_id": "26521576", "label": "methods", "text": "Treatment was given for @ weeks and @ times , @ times a week in the front @ weeks , @ times a week in the latter @ weeks .", "sentence_id": 3}
+{"abstract_id": "26521576", "label": "methods", "text": "In the medication group , conventional symptomatic treatment , support therapy , and complications preventing and treating were adopted for @ weeks .", "sentence_id": 4}
+{"abstract_id": "26521576", "label": "methods", "text": "Anal incontinence score ( Vaizey incontinence score ) , effective rate and self-rating score for satisfaction were observed before and after treatment and in the follow-up period .", "sentence_id": 5}
+{"abstract_id": "26521576", "label": "results", "text": "After @ weeks ' treatment in the two groups , Vaizey incontinence ' scores were both decreased ( both P < @ ) , and after treatment and in the follow-up period the scores in the acupuncture-moxibustion group were lower than those in the corresponding period in the medication group ( both P < @ ) .", "sentence_id": 6}
+{"abstract_id": "26521576", "label": "results", "text": "The effective rate of the acupuncture-moxibustion group was @ % ( @/@ ) , which was statistically different from @ % ( @/@ ) in the medication group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26521576", "label": "results", "text": "The effective rate in the follow-up period of the acupuncture-moxibustion group was @ % ( @/@ ) and it was not statistically different from @ % ( @/@ ) in the medication group ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "26521576", "label": "results", "text": "The self-rating scores for satisfaction in the acupuncture-moxibustion group were superior to those in the medication group after treatment and in the follow-up period ( both P < @ ) .", "sentence_id": 9}
+{"abstract_id": "26521576", "label": "conclusions", "text": "Acupuncture and moxibustion could improve copracrasia and the acupuncture-moxibustion rules and characteristics for the disorder should be paid attention to in the further research .", "sentence_id": 10}
+{"abstract_id": "25380743", "label": "background", "text": "Potential benefits of single-port laparoscopic surgery may include improved cosmetic results , less postoperative pain , surgical trauma and faster recovery .", "sentence_id": 0}
+{"abstract_id": "25380743", "label": "background", "text": "Results of randomized prospective studies with a focus on single-port rectal surgery have not yet been presented .", "sentence_id": 1}
+{"abstract_id": "25380743", "label": "background", "text": "The aim of the present study was to compare single-port and conventional laparoscopic surgery for rectal cancer in terms of short-term outcomes including postoperative pain and trauma-induced changes in certain bioactive substances .", "sentence_id": 2}
+{"abstract_id": "25380743", "label": "methods", "text": "Patients with non-metastasized rectal cancer were prospectively randomized to single-port ( n = @ ) or conventional laparoscopic rectal surgery ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25380743", "label": "methods", "text": "Postoperative pain was assessed at rest , at coughing and during mobilization , with a numeric pain ranking score and was recorded at @ h after the operation and subsequently every morning daily for @ days .", "sentence_id": 4}
+{"abstract_id": "25380743", "label": "methods", "text": "Levels of C-reactive protein ( CRP ) , interleukin-@ ( IL-@ ) and tissue inhibitor of metalloproteinases-@ ( TIMP-@ ) were determined .", "sentence_id": 5}
+{"abstract_id": "25380743", "label": "methods", "text": "Blood samples were collected preoperatively ( baseline ) , and @ , @ , @ , @ and @ h after skin incision .", "sentence_id": 6}
+{"abstract_id": "25380743", "label": "results", "text": "Pain scores were significantly reduced in the single-port group on postoperative days @ , @ and @ during coughing and mobilization .", "sentence_id": 7}
+{"abstract_id": "25380743", "label": "results", "text": "In addition , the patients in the single-port group suffered significantly less pain at rest at @ h after surgery and on postoperative days @ , @ and @ .", "sentence_id": 8}
+{"abstract_id": "25380743", "label": "results", "text": "The levels of the three markers increased significantly after surgery .", "sentence_id": 9}
+{"abstract_id": "25380743", "label": "results", "text": "The increase was similar between groups for plasma IL-@ and TIMP-@ at all time points , while the CRP levels were significantly lower in the single-port group at @ ( p < @ ) and @ h ( p < @ ) after skin incision .", "sentence_id": 10}
+{"abstract_id": "25380743", "label": "results", "text": "Abdominal incisions lengths were significantly shorter in the single-port group ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25380743", "label": "results", "text": "There was no significant difference between groups in operating time and blood loss , morbidity or mortality rate .", "sentence_id": 12}
+{"abstract_id": "25380743", "label": "results", "text": "The short-term oncological outcome in the two groups was similar .", "sentence_id": 13}
+{"abstract_id": "25380743", "label": "conclusions", "text": "Single-port rectal surgery may reduce postoperative pain .", "sentence_id": 14}
+{"abstract_id": "25380743", "label": "conclusions", "text": "Although CRP levels were lower at some time points , results of the present randomized , pilot study suggest that the trauma-induced inflammatory response of single-port operations may be similar to the trauma-induced inflammatory response of conventional laparoscopic surgery .", "sentence_id": 15}
+{"abstract_id": "24594421", "label": "objective", "text": "To compare in dual-energy CT ( DECT ) conventionally reconstructed polyenergetic images ( PEI ) at @ kVp to virtual monoenergetic images ( MEI ) at different kiloelectron volt ( keV ) levels for evaluation of liver and gastrointestinal stromal tumor ( GIST ) hepatic metastases with regard to objective ( IQob ) and subjective image quality ( IQsub ) assessed by two readers of varying experience .", "sentence_id": 0}
+{"abstract_id": "24594421", "label": "objective", "text": "Image quality was correlated to patient size and compared between PEI and MEI .", "sentence_id": 1}
+{"abstract_id": "24594421", "label": "methods", "text": "From @ examinations of @ GIST patients ( @ with hepatic metastases ) undergoing abdominal dual-source DECT for staging , therapy monitoring or follow-up , PEI and nine MEI in @-keV intervals from @ to @ keV were reconstructed .", "sentence_id": 2}
+{"abstract_id": "24594421", "label": "methods", "text": "Liver contrast-to-noise ratios ( CNR ) and metastasis-to-liver ratios were calculated .", "sentence_id": 3}
+{"abstract_id": "24594421", "label": "methods", "text": "MEI reconstructions with the highest IQob were compared to PEI for IQsub by one experienced reader ( ER ) and one inexperienced reader ( IR ) .", "sentence_id": 4}
+{"abstract_id": "24594421", "label": "methods", "text": "Patients ' diameters were correlated to IQob and IQsub ratings .", "sentence_id": 5}
+{"abstract_id": "24594421", "label": "results", "text": "MEI at @ keV had the highest IQob with equal liver CNR and metastasis-to-liver ratio compared to PEI .", "sentence_id": 6}
+{"abstract_id": "24594421", "label": "results", "text": "The ER rated @-keV MEI and PEI equally high ( median @ ) , whereas the IR rated IQsub best in @-keV MEI ( median @ ) .", "sentence_id": 7}
+{"abstract_id": "24594421", "label": "results", "text": "Unlike in PEI , IQsub ratings in @-keV MEI were not correlated to patient size .", "sentence_id": 8}
+{"abstract_id": "24594421", "label": "conclusions", "text": "MEI at @ keV provided an IQob equivalent to PEI .", "sentence_id": 9}
+{"abstract_id": "24594421", "label": "conclusions", "text": "Regarding the IR , IQsub was improved in @-keV MEI compared to PEI and less dependent on patient size .", "sentence_id": 10}
+{"abstract_id": "24594421", "label": "conclusions", "text": "Therefore , IRs might improve their diagnostic confidence in the assessment of hepatic GIST metastases by evaluating MEI reconstructions at @ keV .", "sentence_id": 11}
+{"abstract_id": "24488608", "label": "objective", "text": "Current stroke risk schemes need improvement of predictive value in patients with atrial fibrillation .", "sentence_id": 0}
+{"abstract_id": "24488608", "label": "objective", "text": "Transoesophageal echocardiography ( TEE ) may facilitate stroke risk assessment in such patients and guide antithrombotic treatment .", "sentence_id": 1}
+{"abstract_id": "24488608", "label": "methods", "text": "We randomised @ patients with non-valvular atrial fibrillation and a moderate stroke risk to aspirin or adjusted vitamin K antagonist therapy after TEE had ruled out thrombogenic features in the atria and aorta .", "sentence_id": 2}
+{"abstract_id": "24488608", "label": "methods", "text": "The primary outcome was a composite of stroke , major bleeding , peripheral embolism and all-cause mortality .", "sentence_id": 3}
+{"abstract_id": "24488608", "label": "results", "text": "Mean CHA@DS@-VASc score was @ .", "sentence_id": 4}
+{"abstract_id": "24488608", "label": "results", "text": "The incidences of the composite primary outcome at a mean follow-up of @ years were @ % ( @ % per year ) in the aspirin group compared to @ % ( @ % per year ) in the vitamin K antagonists group with an absolute advantage of @ percentage points .", "sentence_id": 5}
+{"abstract_id": "24488608", "label": "results", "text": "Aspirin was non-inferior to vitamin K antagonists ( p < @ ) because the upper limit of the @ % CI did not exceed the @ % absolute difference in event rate between the two treatment arms .", "sentence_id": 6}
+{"abstract_id": "24488608", "label": "conclusions", "text": "This hypothesis-generating pilot trial has found that TEE may be used for refinement of stroke risk in paroxysmal atrial fibrillation patients .", "sentence_id": 7}
+{"abstract_id": "24488608", "label": "conclusions", "text": "A larger trial is needed to confirm these data .", "sentence_id": 8}
+{"abstract_id": "24488608", "label": "conclusions", "text": "( ClinicalTrials.gov number NTC@ ) .", "sentence_id": 9}
+{"abstract_id": "24736370", "label": "background", "text": "Insecticide-treated nets ( ITNs ) and indoor residual spraying ( IRS ) of houses provide effective malaria transmission control .", "sentence_id": 0}
+{"abstract_id": "24736370", "label": "background", "text": "There is conflicting evidence about whether it is more beneficial to provide both interventions in combination .", "sentence_id": 1}
+{"abstract_id": "24736370", "label": "background", "text": "A cluster randomised controlled trial was conducted to investigate whether the combination provides added protection compared to ITNs alone .", "sentence_id": 2}
+{"abstract_id": "24736370", "label": "results", "text": "In northwest Tanzania , @ clusters ( village areas ) were randomly allocated to ITNs only or ITNs and IRS .", "sentence_id": 3}
+{"abstract_id": "24736370", "label": "results", "text": "Dwellings in the ITN+IRS arm were sprayed with two rounds of bendiocarb in @ .", "sentence_id": 4}
+{"abstract_id": "24736370", "label": "results", "text": "Plasmodium falciparum prevalence rate ( PfPR ) in children @-@ y old ( primary outcome ) and anaemia in children < @ y old ( secondary outcome ) were compared between study arms using three cross-sectional household surveys in @ .", "sentence_id": 5}
+{"abstract_id": "24736370", "label": "results", "text": "Entomological inoculation rate ( secondary outcome ) was compared between study arms .", "sentence_id": 6}
+{"abstract_id": "24736370", "label": "results", "text": "IRS coverage was approximately @ % .", "sentence_id": 7}
+{"abstract_id": "24736370", "label": "results", "text": "ITN use ranged from @ % to @ % .", "sentence_id": 8}
+{"abstract_id": "24736370", "label": "results", "text": "In intention-to-treat analysis , mean PfPR was @ % in the ITN+IRS arm and @ % in the ITN only arm , odds ratio = @ ( @ % CI @-@ @ , n = @,@ ) .", "sentence_id": 9}
+{"abstract_id": "24736370", "label": "results", "text": "The strongest effect was observed in the peak transmission season , @ mo after the first IRS .", "sentence_id": 10}
+{"abstract_id": "24736370", "label": "results", "text": "Subgroup analysis showed that ITN users were additionally protected if their houses were sprayed .", "sentence_id": 11}
+{"abstract_id": "24736370", "label": "results", "text": "Mean monthly entomological inoculation rate was non-significantly lower in the ITN+IRS arm than in the ITN only arm , rate ratio = @ ( @ % CI @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "24736370", "label": "conclusions", "text": "This is the first randomised trial to our knowledge that reports significant added protection from combining IRS and ITNs compared to ITNs alone .", "sentence_id": 13}
+{"abstract_id": "24736370", "label": "conclusions", "text": "The effect is likely to be attributable to IRS providing added protection to ITN users as well as compensating for inadequate ITN use .", "sentence_id": 14}
+{"abstract_id": "24736370", "label": "conclusions", "text": "Policy makers should consider deploying IRS in combination with ITNs to control transmission if local ITN strategies on their own are insufficiently effective .", "sentence_id": 15}
+{"abstract_id": "24736370", "label": "conclusions", "text": "Given the uncertain generalisability of these findings , it would be prudent for malaria control programmes to evaluate the cost-effectiveness of deploying the combination .", "sentence_id": 16}
+{"abstract_id": "25282033", "label": "objective", "text": "The OPTION ( Optimal Anti-Tachycardia Therapy in Implantable Cardioverter-Defibrillator Patients Without Pacing Indications ) trial sought to compare long-term rates of inappropriate shocks , mortality , and morbidity between dual-chamber and single-chamber settings in implantable cardioverter-defibrillators ( ICDs ) patients .", "sentence_id": 0}
+{"abstract_id": "25282033", "label": "background", "text": "The use of dual-chamber ICDs potentially allows better discrimination of supraventricular arrhythmias and thereby reduces inappropriate shocks .", "sentence_id": 1}
+{"abstract_id": "25282033", "label": "background", "text": "However , it may lead to detrimental ventricular pacing .", "sentence_id": 2}
+{"abstract_id": "25282033", "label": "methods", "text": "This prospective multicenter , single-blinded trial enrolled @ patients with de novo primary or secondary prevention indications for ICD placement and with left ventricular ejection fractions @ % despite optimal tolerated pharmacotherapy .", "sentence_id": 3}
+{"abstract_id": "25282033", "label": "methods", "text": "All patients received atrial leads and dual-chamber defibrillators that were randomized to be programmed either with dual-chamber or single-chamber settings .", "sentence_id": 4}
+{"abstract_id": "25282033", "label": "methods", "text": "In the dual-chamber setting arm , the PARAD + algorithm , which differentiates supraventricular from ventricular arrhythmias , and SafeR mode , to minimize ventricular pacing , were activated .", "sentence_id": 5}
+{"abstract_id": "25282033", "label": "methods", "text": "In the single-chamber setting arm , the acceleration , stability , and long cycle search discrimination criteria were activated , and pacing was set to VVI @ beats/min .", "sentence_id": 6}
+{"abstract_id": "25282033", "label": "methods", "text": "Ventricular tachycardia detection was required at rates between @ and @ beats/min , and ventricular fibrillation detection was activated above @ beats/min .", "sentence_id": 7}
+{"abstract_id": "25282033", "label": "results", "text": "During a follow-up period of @ months , the time to the first inappropriate shock was significantly longer in the dual-chamber setting arm ( p = @ , log-rank test ) , and @ % of patients in the dual-chamber setting group compared with @ % in the single-chamber setting group experienced inappropriate shocks ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25282033", "label": "results", "text": "Rates of all-cause death or cardiovascular hospitalization were @ % for the dual-chamber setting group and @ % for the single-chamber setting group and satisfied the pre-defined margin for equivalence ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25282033", "label": "conclusions", "text": "Therapy with dual-chamber settings for ICD discrimination combined with algorithms for minimizing ventricular pacing was associated with reduced risk for inappropriate shock compared with single-chamber settings , without increases in mortality and morbidity .", "sentence_id": 10}
+{"abstract_id": "25282033", "label": "conclusions", "text": "( Optimal Anti-Tachycardia Therapy in Implantable Cardioverter-Defibrillator -LSB- ICD -RSB- Patients Without Pacing Indications -LSB- OPTION -RSB- ; NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24835417", "label": "background", "text": "The purpose of this study is to compare clinical outcomes in the treatment of deep non-contained intrabony defects ( i.e. , with @ % @-wall component and a residual @ - to @-wall component in the most apical part ) using deproteinized bovine bone mineral ( DBBM ) combined with either enamel matrix protein derivative ( EMD ) or collagen membrane ( CM ) .", "sentence_id": 0}
+{"abstract_id": "24835417", "label": "methods", "text": "Forty patients with multiple intrabony defects were enrolled .", "sentence_id": 1}
+{"abstract_id": "24835417", "label": "methods", "text": "Only one non-contained defect per patient with an intrabony depth @ mm located in the interproximal area of single - and multirooted teeth was randomly assigned to the treatment with either EMD + DBBM ( test : n = @ ) or CM + DBBM ( control : n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24835417", "label": "methods", "text": "At baseline and after @ months , clinical parameters including probing depth ( PD ) and clinical attachment level ( CAL ) were recorded .", "sentence_id": 3}
+{"abstract_id": "24835417", "label": "methods", "text": "The primary outcome variable was the change in CAL between baseline and @ months .", "sentence_id": 4}
+{"abstract_id": "24835417", "label": "results", "text": "At baseline , the intrabony component of the defects amounted to @ @ mm for EMD + DBBM and @ @ mm for CM + DBBM sites ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24835417", "label": "results", "text": "The mean CAL gain at sites treated with EMD + DBBM was not statistically significantly different ( P = @ ) compared with CM + DBBM ( @ @ versus @ @ mm ) .", "sentence_id": 6}
+{"abstract_id": "24835417", "label": "results", "text": "No statistically significant difference ( P = @ ) was observed comparing the frequency of CAL gain @ mm between EMD + DBBM ( @ % ) and CM + DBBM ( @ % ) or comparing the frequency of residual PD @ mm between EMD + DBBM ( @ % ) and CM + DBBM ( @ % ) ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24835417", "label": "conclusions", "text": "Within the limitations of the present study , regenerative therapy using either EMD + DBBM or CM + DBBM yielded comparable clinical outcomes in deep non-contained intrabony defects after @ months .", "sentence_id": 8}
+{"abstract_id": "24946631", "label": "objective", "text": "To compare the differences in the clinical function and lumbar and abdominal myodynamia in patiants of lumbar disc herniation treated with moxibustion at Dazhui ( GV @ ) and Guanyuan ( CV @ ) and acupuncture .", "sentence_id": 0}
+{"abstract_id": "24946631", "label": "methods", "text": "Forty cases were randomized into a moxibustion group and an acupuncture group , @ cases in each group .", "sentence_id": 1}
+{"abstract_id": "24946631", "label": "methods", "text": "In the moxibustion group , the warm moxibustion was applied alternatively at Dazhui ( GV @ ) and Guanyuan ( CV @ ) once every other day , @ h each time , once every day .", "sentence_id": 2}
+{"abstract_id": "24946631", "label": "methods", "text": "In the acupuncture group , acupuncture was applied to the corresponding acupoints based on the affected lumbar vertebras , such as Jiaji ( EX-B @ ) , Shens-hu ( BL @ ) , Dachangshu ( BL @ ) and Huantiao ( GB @ ) , etc. , once evey day @ min each time .", "sentence_id": 3}
+{"abstract_id": "24946631", "label": "methods", "text": "The treatment for @ weeks was taken as one session in each group .", "sentence_id": 4}
+{"abstract_id": "24946631", "label": "methods", "text": "Totally , one session treatment was required .", "sentence_id": 5}
+{"abstract_id": "24946631", "label": "methods", "text": "Surface electromyography ( SEMG ) of bilateral paraspinal muscle and rectus muscle , and JOA score of low back pain were observed in the two groups .", "sentence_id": 6}
+{"abstract_id": "24946631", "label": "results", "text": "( @ ) JOA score : the score of subjective symptoms , score of activity of daily living ( ADL ) and total score were improved obviously as compared with those before treatment in the two groups ( P < @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24946631", "label": "results", "text": "The results of subjective symptoms score , score of ADL and total score in the acupuncture group were superior to those in the moxibustion group after treatment ( @ + / -@ vs @ + / -@,@ + / -@ vs @ + / - @,@ + / - @ vs @ + / - @ , all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24946631", "label": "results", "text": "( @ ) SEMG comparison : root-mean-square value ( RMS ) was all reduced in SEMG of the anteflexion , rear protraction , orthostatism , bilateral bending and neck and leg rear flexion for strengthening lumbar muscle as compared with those before treatment in the two groups ( P < @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24946631", "label": "results", "text": "RMS of the anteflexion and bilateral bending in the acupunture group were reduced much obviously as compared with the moxibustion group .", "sentence_id": 10}
+{"abstract_id": "24946631", "label": "results", "text": "In terms of sitting position anteflexion , rear protraction , orthostatism , bilateral bending and neck and leg rear flexion for strengthening lumbar muscle , median frequency ( MF ) after treatment was all improved as compared with that before treatment in the two groups ( P < @ , P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24946631", "label": "results", "text": "In terms of anteflexion , the electrode MF after treatment was improved much obviously in the acupuncture group ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24946631", "label": "conclusions", "text": "Moxibustion at Dazhui ( GV @ ) and Guanyuan ( CV @ ) and conventional acupuncture all improve muscle function , relieve muscle fatigue , increase the ability of anti-muscle fatigue , strengthen lumbar vertebral stability , release subjective symptoms and improve ADL .", "sentence_id": 13}
+{"abstract_id": "24946631", "label": "conclusions", "text": "But , the effects of moxibustion are slightly lower than those of acupuncture .", "sentence_id": 14}
+{"abstract_id": "24278929", "label": "objective", "text": "The aim of this study was to compare clinical outcomes and stability following immediate loading of two types of tapered implants in the partially edentulous posterior maxilla and mandible .", "sentence_id": 0}
+{"abstract_id": "24278929", "label": "methods", "text": "A randomized controlled trial with @ year of follow-up was performed on participants missing two consecutive teeth in a posterior quadrant with tapered implants with a hybrid textured surface .", "sentence_id": 1}
+{"abstract_id": "24278929", "label": "methods", "text": "Group @ received Osstem TSIII HA implants , and group @ received Zimmer TSV implants .", "sentence_id": 2}
+{"abstract_id": "24278929", "label": "methods", "text": "Group @ implants were @ or @ mm in diameter , and group @ implants were @ mm in diameter ; all implants were @ mm long .", "sentence_id": 3}
+{"abstract_id": "24278929", "label": "methods", "text": "Subjects received provisional restorations within @ hours .", "sentence_id": 4}
+{"abstract_id": "24278929", "label": "methods", "text": "Definitive restorations were provided @ months ( mandible ) or @ months ( maxilla ) later .", "sentence_id": 5}
+{"abstract_id": "24278929", "label": "methods", "text": "Outcome measures were survival and success rates , marginal bone level change , implant stability quotient , and peri-implant soft tissue indices .", "sentence_id": 6}
+{"abstract_id": "24278929", "label": "results", "text": "Fifty participants completed the trial ( group @ : @ implants in @ patients ; group @ : @ implants in @ patients ) .", "sentence_id": 7}
+{"abstract_id": "24278929", "label": "results", "text": "The success rates were similar -- @ % in group @ and @ % in group @ -- at @ months after immediate loading , but marginal bone loss was significantly different according to the implant design .", "sentence_id": 8}
+{"abstract_id": "24278929", "label": "results", "text": "Implant stability increased significantly in both arches .", "sentence_id": 9}
+{"abstract_id": "24278929", "label": "results", "text": "There were no significant differences in soft tissue indices between implant systems .", "sentence_id": 10}
+{"abstract_id": "24278929", "label": "conclusions", "text": "If high primary stability is acquired , tapered implants with hybrid textured surfaces are predictable for immediate loading in the posterior maxilla and mandible .", "sentence_id": 11}
+{"abstract_id": "24278929", "label": "conclusions", "text": "In spite of the influence of implant design on marginal bone loss , all tapered implants showed successful clinical outcomes and stability in immediate loading .", "sentence_id": 12}
+{"abstract_id": "24375220", "label": "background", "text": "Cardiac surgery and sternotomy are procedures accompanied by substantial postoperative pain which is challenging to treat .", "sentence_id": 0}
+{"abstract_id": "24375220", "label": "background", "text": "In general , intravenous ( IV ) opioids are used in the immediate postoperative phase , followed by oral opioids .", "sentence_id": 1}
+{"abstract_id": "24375220", "label": "background", "text": "Oral opioids are easier to use and generally less expensive .", "sentence_id": 2}
+{"abstract_id": "24375220", "label": "background", "text": "Our goal was thus to determine whether a new opioid preparation provides adequate analgesia after sternotomy .", "sentence_id": 3}
+{"abstract_id": "24375220", "label": "background", "text": "In particular , we tested the primary hypothesis that total opioid use ( in morphine equivalents ) is not greater with oral opioid compared with patient-controlled IV morphine .", "sentence_id": 4}
+{"abstract_id": "24375220", "label": "background", "text": "Our secondary hypothesis was that analgesic efficacy is similar with oral and IV opioids .", "sentence_id": 5}
+{"abstract_id": "24375220", "label": "methods", "text": "A total of @ patients having elective cardiac surgery were enrolled in this study .", "sentence_id": 6}
+{"abstract_id": "24375220", "label": "methods", "text": "After rapid postoperative respiratory weaning , the patients were randomised into one of two groups receiving different types of analgesia : oral Targin ( a combination of oxycodone-hydrochloride and the opioid antagonist naloxone hydrochloride-dihydrate ) or patient-controlled IV morphine .", "sentence_id": 7}
+{"abstract_id": "24375220", "label": "methods", "text": "Pain score ( visual analogue scale ) , sedation ( Ramsey score ) , respiratory rate and side effects were assessed at @ , @ , @ , @ and @ h after surgery , and every @ h throughout the third postoperative evening .", "sentence_id": 8}
+{"abstract_id": "24375220", "label": "results", "text": "The total opioid dose in morphine equivalent doses was significantly lower with oral opioid than with IV morphine ( adjusted geometric means -LSB- @ % confidence interval -RSB- : @ -LSB- @ ; @ -RSB- vs. @ -LSB- @ ; @ -RSB- mg , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24375220", "label": "results", "text": "Pain scores were similar in each group .", "sentence_id": 10}
+{"abstract_id": "24375220", "label": "conclusions", "text": "Analgesic quality was comparable with oral and IV opioids , suggesting that postoperative pain even after very painful procedures can be sufficiently managed with oral opioids .", "sentence_id": 11}
+{"abstract_id": "24603110", "label": "objective", "text": "To evaluate the safety and feasibility of percutaneous tract dilation by the one-stage method in preschool children .", "sentence_id": 0}
+{"abstract_id": "24603110", "label": "methods", "text": "Between April @ and February @ , all preschool ( < @ years ) children who were candidates for percutaneous nephrolithotomy were enrolled in this prospective study .", "sentence_id": 1}
+{"abstract_id": "24603110", "label": "methods", "text": "Patients were randomly assigned to dilation by serial metallic dilators ( group I , @ patients ) or dilation by one-stage Amplatz according to Frattini et al. -LSB- J Endourol @ ; @:@ -@ -RSB- ( group II , @ patients ) .", "sentence_id": 2}
+{"abstract_id": "24603110", "label": "methods", "text": "The primary endpoint of interest was fluoroscopy time .", "sentence_id": 3}
+{"abstract_id": "24603110", "label": "methods", "text": "Secondary endpoints included tract creation and dilation time , success rate and complications .", "sentence_id": 4}
+{"abstract_id": "24603110", "label": "methods", "text": "Stone-free status was defined as residuals @ mm .", "sentence_id": 5}
+{"abstract_id": "24603110", "label": "results", "text": "Age , stone size , operation success and operation time were not significantly different between the studied groups .", "sentence_id": 6}
+{"abstract_id": "24603110", "label": "results", "text": "The most common stone composition was calcium oxalate in both groups .", "sentence_id": 7}
+{"abstract_id": "24603110", "label": "results", "text": "The mean standard deviation of access and fluoroscopy times in groups I and II were @ @ min vs. @ @ min ( p > @ ) and @ @ s vs. @ @ s ( p < @ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "24603110", "label": "results", "text": "Postoperative complications included one case of postoperative fever lasting less than @ h in group I.", "sentence_id": 9}
+{"abstract_id": "24603110", "label": "conclusions", "text": "Percutaneous tract dilation by the one-stage method is safe and effective .", "sentence_id": 10}
+{"abstract_id": "24603110", "label": "conclusions", "text": "Also , it is associated with considerably less radiation exposure in preschool children .", "sentence_id": 11}
+{"abstract_id": "25330837", "label": "objective", "text": "To evaluate the effect of dehydroepiandrosterone ( DHEA ) on infertility patients with diminished ovarian reserve undergoing in vitro fertilization .", "sentence_id": 0}
+{"abstract_id": "25330837", "label": "methods", "text": "This is a prospective study .", "sentence_id": 1}
+{"abstract_id": "25330837", "label": "methods", "text": "Ninety-five patients with diminished ovarian reserve were included in this study .", "sentence_id": 2}
+{"abstract_id": "25330837", "label": "methods", "text": "Of them , @ patients were randomly allocated to the DHEA group , who received DHEA @ mg daily for three consecutive menstrual cycles prior to IVF cycles , and @ patients were allocated to the control group , who entered IVF cycles directly .", "sentence_id": 3}
+{"abstract_id": "25330837", "label": "methods", "text": "All patients were treated with the same ovarian stimulation protocol .", "sentence_id": 4}
+{"abstract_id": "25330837", "label": "methods", "text": "Follicular fluid samples from both groups were collected for bone morphogenetic protein-@ ( BMP-@ ) and growth differentiation factor-@ ( GDF-@ ) .", "sentence_id": 5}
+{"abstract_id": "25330837", "label": "methods", "text": "Fluid from the first aspirated follicle without any visible blood contamination was carefully collected .", "sentence_id": 6}
+{"abstract_id": "25330837", "label": "methods", "text": "In addition , day @ Blood samples were collected pre - and post-treatment of DHEA for serum anti-Mullerian hormone ( AMH ) , follicle stimulating hormone ( FSH ) and estradiol ( E@ ) in the DHEA group .", "sentence_id": 7}
+{"abstract_id": "25330837", "label": "results", "text": "The level of BMP-@ in follicular fluid samples from the DHEA group was significantly higher than that of the control samples ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25330837", "label": "results", "text": "Patients after DHEA treatment demonstrated a significantly higher level of AMH and a significantly lower level of FSH , E@ compared to themselves prior to DHEA therapy ( P = @ ; P = @ ; P = @ ; respectively ) .", "sentence_id": 9}
+{"abstract_id": "25330837", "label": "results", "text": "Moreover , the accumulated score of embryos was significantly higher in the DHEA group ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25330837", "label": "conclusions", "text": "These observations confirm the beneficial effect of DHEA for infertility patients with diminished ovarian reserve .", "sentence_id": 11}
+{"abstract_id": "25525891", "label": "objective", "text": "To compare subjective and objective visual performance of the Air Optix Aqua Multifocal lens to monovision in a group of subjects requiring a medium level of reading-addition power .", "sentence_id": 0}
+{"abstract_id": "25525891", "label": "methods", "text": "Fifty participants with reading additions between @ and @ diopters ( inclusive ) were randomized into a prospective , crossover clinical trial .", "sentence_id": 1}
+{"abstract_id": "25525891", "label": "methods", "text": "They wore monovision and multifocals for @ weeks in a randomized order .", "sentence_id": 2}
+{"abstract_id": "25525891", "label": "methods", "text": "High - and low-contrast logMAR ( logarithm of the minimum angle of resolution ) acuity and stereopsis were measured at the beginning and end of each period .", "sentence_id": 3}
+{"abstract_id": "25525891", "label": "methods", "text": "During each phase , participants performed specific tasks followed by subjective rating surveys and also completed satisfaction rating surveys on days @ , @ , and @ ; all were transferred in real time using BlackBerry smartphones .", "sentence_id": 4}
+{"abstract_id": "25525891", "label": "methods", "text": "A general rating survey was completed at the dispensing and @-week visits .", "sentence_id": 5}
+{"abstract_id": "25525891", "label": "results", "text": "Forty-nine participants completed the study ( mean age , @ years ) .", "sentence_id": 6}
+{"abstract_id": "25525891", "label": "results", "text": "Distance and near high - and low-contrast acuities were significantly better ( p < @ ) with monovision at all visits .", "sentence_id": 7}
+{"abstract_id": "25525891", "label": "results", "text": "High-contrast intermediate acuity was only better ( p < @ ) with multifocals after @ weeks .", "sentence_id": 8}
+{"abstract_id": "25525891", "label": "results", "text": "Stereopsis was equivalent after @ weeks , but better ( p < @ ) with multifocals at dispensing .", "sentence_id": 9}
+{"abstract_id": "25525891", "label": "results", "text": "Subjective ratings were generally equivalent between modalities although there was a trend for multifocals to be rated higher for focus changing and driving , whereas monovision tended to be rated higher for near tasks .", "sentence_id": 10}
+{"abstract_id": "25525891", "label": "results", "text": "For both corrections , the satisfaction survey showed no significant change between days @ , @ , and @ , and the general survey showed that comfort was maintained but subjective vision ratings decreased significantly over the @ weeks .", "sentence_id": 11}
+{"abstract_id": "25525891", "label": "results", "text": "Twenty-five participants ( @ % ) preferred multifocals , @ ( @ % ) preferred monovision , and the remaining @ ( @ % ) declared both unacceptable .", "sentence_id": 12}
+{"abstract_id": "25525891", "label": "conclusions", "text": "In this cohort , distance and near acuities were better with monovision , whereas the subjective ratings tended to favor the Air Optix Aqua Multifocal , with the exception of near performance .", "sentence_id": 13}
+{"abstract_id": "25525891", "label": "conclusions", "text": "Preference was statistically similar between both corrections , with a trend toward preferring the multifocal .", "sentence_id": 14}
+{"abstract_id": "25414061", "label": "background", "text": "Natural orifice transluminal endoscopic surgery ( NOTES ) is the consequence of further development of minimally invasive surgery to reduce abdominal incisions and surgical trauma .", "sentence_id": 0}
+{"abstract_id": "25414061", "label": "background", "text": "The potential benefits are expected to be less postoperative pain , faster convalescence , and reduced risk for incisional hernias and wound infections compared to conventional methods .", "sentence_id": 1}
+{"abstract_id": "25414061", "label": "background", "text": "Recent clinical studies have demonstrated the feasibility and safety of transvaginal NOTES , and transvaginal access is currently the most frequent clinically applied route for NOTES procedures .", "sentence_id": 2}
+{"abstract_id": "25414061", "label": "background", "text": "However , despite increasing clinical application , no firm clinical evidence is available for objective assessment of the potential benefits and risks of transvaginal NOTES compared to the current surgical standard .", "sentence_id": 3}
+{"abstract_id": "25414061", "label": "methods", "text": "The TRANSVERSAL trial is designed as a randomized controlled trial to compare transvaginal hybrid NOTES and laparoscopic-assisted sigmoid resection .", "sentence_id": 4}
+{"abstract_id": "25414061", "label": "methods", "text": "Female patients referred to elective sigmoid resection due to complicated or reoccurring diverticulitis of the sigmoid colon are considered eligible .", "sentence_id": 5}
+{"abstract_id": "25414061", "label": "methods", "text": "The primary endpoint will be pain intensity during mobilization @ hours postoperatively as measured by the blinded patient and blinded assessor on a visual analogue scale ( VAS ) .", "sentence_id": 6}
+{"abstract_id": "25414061", "label": "methods", "text": "Secondary outcomes include daily pain intensity and analgesic use , patient mobility , intraoperative complications , morbidity , length of stay , quality of life , and sexual function .", "sentence_id": 7}
+{"abstract_id": "25414061", "label": "methods", "text": "Follow-up visits are scheduled @ , @ , and @ months after surgery .", "sentence_id": 8}
+{"abstract_id": "25414061", "label": "methods", "text": "A total sample size of @ patients was determined for the analysis of the primary endpoint .", "sentence_id": 9}
+{"abstract_id": "25414061", "label": "methods", "text": "The confirmatory analysis will be performed based on the intention-to-treat ( ITT ) principle .", "sentence_id": 10}
+{"abstract_id": "25414061", "label": "conclusions", "text": "The TRANSVERSAL trial is the first study to compare transvaginal hybrid NOTES and conventionally assisted laparoscopic surgery for colonic resection in a randomized controlled setting .", "sentence_id": 11}
+{"abstract_id": "25414061", "label": "conclusions", "text": "The results of the TRANSVERSAL trial will allow objective assessment of the potential benefits and risks of NOTES compared to the current surgical standard for sigmoid resection .", "sentence_id": 12}
+{"abstract_id": "25539823", "label": "background", "text": "Aetiology of childhood leukaemia and childhood neoplasm is poorly understood .", "sentence_id": 0}
+{"abstract_id": "25539823", "label": "background", "text": "Information on the prevalence of risk factors in the childhood population is limited .", "sentence_id": 1}
+{"abstract_id": "25539823", "label": "background", "text": "SETIL is a population based case-control study on childhood leukaemia , conducted with two companion studies on non-Hodgkin Lymphoma ( NHL ) and neuroblastoma .", "sentence_id": 2}
+{"abstract_id": "25539823", "label": "background", "text": "The study relies on questionnaire interviews and @ Hz magnetic field ( ELF-MF ) indoor measurements .", "sentence_id": 3}
+{"abstract_id": "25539823", "label": "background", "text": "This paper discusses the SETIL study design and includes descriptive information .", "sentence_id": 4}
+{"abstract_id": "25539823", "label": "methods", "text": "The study was carried out in @ Italian regions ( @ % of Italian population aged @-@ ) .", "sentence_id": 5}
+{"abstract_id": "25539823", "label": "methods", "text": "It included leukaemia , NHL and neuroblastoma cases incident in @-@ year olds in @-@ , registered by the Italian Association of Paediatric Haematology and Oncology ( AIEOP ) ( accrual over @ % of estimated incidence ) .", "sentence_id": 6}
+{"abstract_id": "25539823", "label": "methods", "text": "Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls , matched by gender , birthdate and residence .", "sentence_id": 7}
+{"abstract_id": "25539823", "label": "methods", "text": "The same controls were used in NHL and neuroblastoma studies .", "sentence_id": 8}
+{"abstract_id": "25539823", "label": "methods", "text": "Parents were interviewed at home on : physical agents ( ELF-MF and ionizing radiation ) , chemicals ( smoking , solvents , traffic , insecticides ) , occupation , medical and personal history of children and parents , infectious diseases , immunizations and associated factors .", "sentence_id": 9}
+{"abstract_id": "25539823", "label": "methods", "text": "Occupational exposure was collected using job specific modules .", "sentence_id": 10}
+{"abstract_id": "25539823", "label": "methods", "text": "ELF-MF was measured in the main rooms ( spot measurement ) and close to child 's bed ( @ hours measurement ) .", "sentence_id": 11}
+{"abstract_id": "25539823", "label": "results", "text": "The study included : @ leukaemia cases ( @ % ALL , @ % AnLL ) , @ NHL , @ neuroblastomas , and @ controls .", "sentence_id": 12}
+{"abstract_id": "25539823", "label": "conclusions", "text": "SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors .", "sentence_id": 13}
+{"abstract_id": "24770617", "label": "background", "text": "Highly HLA-sensitized ( HS ) patients have difficulty accessing compatible donors , especially deceased donor ( DD ) transplants .", "sentence_id": 0}
+{"abstract_id": "24770617", "label": "background", "text": "Desensitization protocols ( DES ) have evolved , but rigorous evaluation is lacking .", "sentence_id": 1}
+{"abstract_id": "24770617", "label": "background", "text": "Here , we examined the efficacy of rituximab as a DES agent in a placebo-controlled trial .", "sentence_id": 2}
+{"abstract_id": "24770617", "label": "methods", "text": "Candidates were randomized to IVIG + placebo versus IVIG + rituximab .", "sentence_id": 3}
+{"abstract_id": "24770617", "label": "methods", "text": "End points included rates of transplantation , antibody-mediated rejection ( ABMR ) , and renal function .", "sentence_id": 4}
+{"abstract_id": "24770617", "label": "methods", "text": "Protocol biopsies were performed at @ year and analysis of patient and graft survival and donor-specific HLA antibodies ( DSA ) were performed .", "sentence_id": 5}
+{"abstract_id": "24770617", "label": "results", "text": "Initially , @ HS DDs were randomized with @ receiving transplants .", "sentence_id": 6}
+{"abstract_id": "24770617", "label": "results", "text": "However , we discontinued study entry after five serious adverse events were observed .", "sentence_id": 7}
+{"abstract_id": "24770617", "label": "results", "text": "The study was un-blinded and attribution of patients was noted ( IVIG + placebo N = @ , IVIG + rituximab N = @ ) .", "sentence_id": 8}
+{"abstract_id": "24770617", "label": "results", "text": "No significant differences were seen in DSA levels at transplant .", "sentence_id": 9}
+{"abstract_id": "24770617", "label": "results", "text": "All ABMR episodes occurred in the IVIG + placebo arm and required intense therapy ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24770617", "label": "results", "text": "The two graft losses were in the placebo group .", "sentence_id": 11}
+{"abstract_id": "24770617", "label": "results", "text": "DSA rebound associated with severe ABMR was seen in three patients in the IVIG + placebo group .", "sentence_id": 12}
+{"abstract_id": "24770617", "label": "results", "text": "No rebound was seen in the IVIG + rituximab group .", "sentence_id": 13}
+{"abstract_id": "24770617", "label": "results", "text": "Renal function at @ and @ months showed a significant benefit for IVIG + rituximab ( P = @ ) .", "sentence_id": 14}
+{"abstract_id": "24770617", "label": "conclusions", "text": "Based on limited assessment with acknowledged limitations , both protocols appear effective in achieving levels of DSA allowable for transplantation .", "sentence_id": 15}
+{"abstract_id": "24770617", "label": "conclusions", "text": "However , IVIG + rituximab appeared more effective in preventing DSA rebound and , more importantly , preventing ABMR and development of transplant glomerulopathy .", "sentence_id": 16}
+{"abstract_id": "24953368", "label": "objective", "text": "To evaluate the clinical efficacy and safety of tissue-selecting therapy ( TST ) in treatment of mixed hemorrhoids .", "sentence_id": 0}
+{"abstract_id": "24953368", "label": "methods", "text": "A single-blind randomized study was carried out .", "sentence_id": 1}
+{"abstract_id": "24953368", "label": "methods", "text": "A total of @ patients with mixed hemorrhoids from January to December @ were prospectively enrolled in the study and equally divided into two groups , TST group and procedure for prolapse and hemorrhoids ( PPH ) group .", "sentence_id": 2}
+{"abstract_id": "24953368", "label": "methods", "text": "Surgical data , efficacy and postoperative complications were compared between the two groups .", "sentence_id": 3}
+{"abstract_id": "24953368", "label": "results", "text": "As compared to PPH group , patients in TST group had shorter operation time -LSB- ( @ ) min vs. ( @ ) min , P < @ -RSB- , lower scores of rectal urgency ( @ vs. @ , P < @ ) , and shorter hospital stay -LSB- ( @ ) d vs. ( @ ) d , P < @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "24953368", "label": "results", "text": "No anastomotic stricture case was found in TST group , while @ cases ( @ % ) developed anastomotic stricture in PPH group .", "sentence_id": 5}
+{"abstract_id": "24953368", "label": "results", "text": "There were no significant differences in effective rate and pain score of first defecation between the two groups .", "sentence_id": 6}
+{"abstract_id": "24953368", "label": "conclusions", "text": "TST is reliable and safe for mixed hemorrhoids with the advantage of simple , rapid recovery and less complications .", "sentence_id": 7}
+{"abstract_id": "25234524", "label": "objective", "text": "The surgical removal of mandibular third molars is frequently accompanied by significant postsurgicalsequelae , and different protocols have been described to decrease such adverse events .", "sentence_id": 0}
+{"abstract_id": "25234524", "label": "objective", "text": "The aim of this study was to investigate the performance of piezosurgery compared with traditional rotating instrumentsduring mandibular third molar removal .", "sentence_id": 1}
+{"abstract_id": "25234524", "label": "methods", "text": "A single-center , randomized , split-mouth study was performed using a consecutive series of unrelated healthy patients attending the Oral Surgery Unit of the University of Turin for surgical removal of bilateral mandibular third molar teeth .", "sentence_id": 2}
+{"abstract_id": "25234524", "label": "methods", "text": "Each patient was treated , at the same appointment , using bur removal on @ side of the mandible and a piezoelectric device on the contralateral side .", "sentence_id": 3}
+{"abstract_id": "25234524", "label": "methods", "text": "The primaryoutcomes reported were postoperative pain , objective orofacial swelling , and surgical duration ; secondary outcomes were gender , age , and possible adverse events .", "sentence_id": 4}
+{"abstract_id": "25234524", "label": "methods", "text": "Analysis of variance or paired t test was used as appropriate to test any significant differences at baseline according to each treatment subgroup , and categorical variables were analyzed by ( @ ) test .", "sentence_id": 5}
+{"abstract_id": "25234524", "label": "results", "text": "The study sample consisted of @ otherwise healthy patients .", "sentence_id": 6}
+{"abstract_id": "25234524", "label": "results", "text": "The mean pain evaluation reportedby patients who underwent surgery with piezosurgery was significantly lower than that reported after bur ( conventional ) removal , reaching statistical difference after @ days ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25234524", "label": "results", "text": "The clinical value oforofacial swelling at day @ , normalized to baseline , was lower in the piezosurgery group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25234524", "label": "results", "text": "Theaverage surgical duration was significantly shorter in the bur group than in the piezosurgery group ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25234524", "label": "results", "text": "Three patients having bur removal developed short-term complications ( @ dry sockets and @temporaryparaesthesia ) , which totally resolved by @ weeks .", "sentence_id": 10}
+{"abstract_id": "25234524", "label": "conclusions", "text": "To date , this prospective investigation is the largest reported split-mouth study on piezosurgeryfor lower third molar tooth removal .", "sentence_id": 11}
+{"abstract_id": "25234524", "label": "conclusions", "text": "This study also compared surgeons with different degreesof experience .", "sentence_id": 12}
+{"abstract_id": "25234524", "label": "conclusions", "text": "It is evident that using a piezoelectric device can enhance the patient experience and decrease postoperative pain and swelling .", "sentence_id": 13}
+{"abstract_id": "25266438", "label": "objective", "text": "To evaluate efficacy and safety of eszopiclone compared with placebo in children and adolescents with insomnia associated with attention-deficit/hyperactivity disorder ( ADHD ) .", "sentence_id": 0}
+{"abstract_id": "25266438", "label": "methods", "text": "A @-week , randomized , double-blind , placebo-controlled trial evaluated efficacy and safety of high - or low-dose eszopiclone ( @ or @ mg in children aged @-@ years , @ or @ mg in children ages @-@ years ) , given every evening , in @ patients with ADHD-related insomnia .", "sentence_id": 1}
+{"abstract_id": "25266438", "label": "methods", "text": "The primary efficacy variable was change in latency to persistent sleep from baseline to week @ , based on polysomnography .", "sentence_id": 2}
+{"abstract_id": "25266438", "label": "methods", "text": "Key secondary measures were polysomnography-measured wake time after sleep onset , Clinical Global Impression Parent/Caregiver and Child scales , and the Conners ' ADHD rating scales .", "sentence_id": 3}
+{"abstract_id": "25266438", "label": "methods", "text": "The safety of eszopiclone was further studied over @ year of open-label treatment in @ patients who completed the double-blind study , and @ patients with no previous eszopiclone exposure .", "sentence_id": 4}
+{"abstract_id": "25266438", "label": "results", "text": "Neither low-dose nor high-dose eszopiclone significantly reduced latency to persistent sleep compared with placebo after @ weeks of treatment .", "sentence_id": 5}
+{"abstract_id": "25266438", "label": "results", "text": "Secondary outcomes were considered nonsignificant based on the hierarchical statistical analysis plan .", "sentence_id": 6}
+{"abstract_id": "25266438", "label": "results", "text": "The most frequent treatment-emergent adverse events over @ weeks with eszopiclone were headache , dysgeusia , and dizziness .", "sentence_id": 7}
+{"abstract_id": "25266438", "label": "results", "text": "The study results demonstrated that eszopiclone was well tolerated over @ year of treatment , with @ % of patients discontinuing open-label treatment because of an adverse event .", "sentence_id": 8}
+{"abstract_id": "25266438", "label": "conclusions", "text": "Eszopiclone ( up to @ mg ) failed to reduce latency to persistent sleep on polysomnography after @ weeks in children aged @ to @ years with ADHD-related insomnia .", "sentence_id": 9}
+{"abstract_id": "25266438", "label": "conclusions", "text": "Eszopiclone was well tolerated in the @-year study .", "sentence_id": 10}
+{"abstract_id": "24252663", "label": "background", "text": "Cognitive-behavioral therapy ( CBT ) has demonstrated efficacy and effectiveness for treating mood and anxiety disorders .", "sentence_id": 0}
+{"abstract_id": "24252663", "label": "background", "text": "Dissemination of CBT via videoconference may help improve access to treatment .", "sentence_id": 1}
+{"abstract_id": "24252663", "label": "objective", "text": "The present study aimed to compare the effectiveness of CBT administered via videoconference to in-person therapy for a mixed diagnostic cohort .", "sentence_id": 2}
+{"abstract_id": "24252663", "label": "methods", "text": "A total of @ primarily Caucasian clients ( mean age @ years , SD @ ) who had a primary Diagnostic and Statistical Manual of Mental Disorders , @th edition text revision ( DSM-IV-TR ) diagnosis of a mood or anxiety disorder were randomly assigned to receive @ sessions of CBT either in-person or via videoconference .", "sentence_id": 3}
+{"abstract_id": "24252663", "label": "methods", "text": "Treatment involved individualized CBT formulations specific to the presenting diagnosis ; all sessions were provided by the same therapist .", "sentence_id": 4}
+{"abstract_id": "24252663", "label": "methods", "text": "Participants were recruited through a university clinic .", "sentence_id": 5}
+{"abstract_id": "24252663", "label": "methods", "text": "Symptoms of depression , anxiety , stress , and quality of life were assessed using questionnaires before , after , and @ weeks following treatment .", "sentence_id": 6}
+{"abstract_id": "24252663", "label": "methods", "text": "Secondary outcomes at posttreatment included working alliance and client satisfaction .", "sentence_id": 7}
+{"abstract_id": "24252663", "label": "results", "text": "Retention was similar across treatment conditions ; there was one more client in the videoconferencing condition at posttreatment and at follow-up .", "sentence_id": 8}
+{"abstract_id": "24252663", "label": "results", "text": "Statistical analysis using multilevel mixed effects linear regression indicated a significant reduction in client symptoms across time for symptoms of depression ( P < @ , d = @ ) , anxiety ( P < @ , d = @ ) , stress ( P < @ , d = @ ) , and quality of life ( P < @ , d = @ ) .", "sentence_id": 9}
+{"abstract_id": "24252663", "label": "results", "text": "There were no significant differences between treatment conditions regarding symptoms of depression ( P = @ , d = @ ) , anxiety ( P = @ , d = @ ) , stress ( P = @ , d = @ ) , or quality of life ( P = @ , d = @ ) .", "sentence_id": 10}
+{"abstract_id": "24252663", "label": "results", "text": "There were no significant differences in client rating of the working alliance ( P = @ , one-tailed , d = -@ ) , therapist ratings of the working alliance ( P = @ , one-tailed , d = @ ) , or client ratings of satisfaction ( P = @ , one-tailed , d = -@ ) .", "sentence_id": 11}
+{"abstract_id": "24252663", "label": "results", "text": "Fisher 's Exact P was not significant regarding differences in reliable change from pre - to posttreatment or from pretreatment to follow-up for symptoms of depression ( P = @ , P = @ ) , anxiety ( P = @ , P = @ ) , or quality of life ( P = @ , P = @ ) but was significant for symptoms of stress in favor of the videoconferencing condition ( P = @ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24252663", "label": "results", "text": "Difference between conditions regarding clinically significant change was also not observed from pre - to posttreatment or from pretreatment to follow-up for symptoms of depression ( P = @ , P = @ ) , anxiety ( P = @ , P = @ ) , stress ( P = @ , P = @ ) , or quality of life ( P = @ , P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24252663", "label": "conclusions", "text": "The findings of this controlled trial indicate that CBT was effective in significantly reducing symptoms of depression , anxiety , and stress and increasing quality of life in both in-person and videoconferencing conditions , with no significant differences being observed between the two .", "sentence_id": 14}
+{"abstract_id": "25059523", "label": "background", "text": "The aim of this study was to investigate the effects of mass drug administration on Schistosoma mansoni prevalence and associated liver morbidity in treated school-aged children and untreated preschool children .", "sentence_id": 0}
+{"abstract_id": "25059523", "label": "methods", "text": "In April @ , parasitological ( using the Kato-Katz method ) and morbidity ( determined by portal vein score ) data were collected from @ schoolchildren aged @ and @ years .", "sentence_id": 1}
+{"abstract_id": "25059523", "label": "methods", "text": "The children had never received praziquantel .", "sentence_id": 2}
+{"abstract_id": "25059523", "label": "methods", "text": "In March @ , following two annual rounds of mass drug administration , @ children aged @ and @ years old were examined to determine the effect of treatment .", "sentence_id": 3}
+{"abstract_id": "25059523", "label": "methods", "text": "In addition , @ untreated @-year-olds were assessed to compare with the untreated children from @ .", "sentence_id": 4}
+{"abstract_id": "25059523", "label": "results", "text": "Treatment significantly decreased the prevalence of S. mansoni and associated morbidity in the treated groups .", "sentence_id": 5}
+{"abstract_id": "25059523", "label": "results", "text": "The untreated preschool children also showed a significant decrease in the prevalence of S. mansoni , from @ % ( @ ) to @ % ( @ ) ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25059523", "label": "results", "text": "The percentage of untreated schoolchildren with a normal portal vein score increased significantly from @ % ( @ ) to @ % ( @ ) ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25059523", "label": "conclusions", "text": "The significantly lower rates of S. mansoni and the decreased liver morbidity in untreated preschool children in @ suggest decreased environmental transmission rates and improved liver morbidity in untreated children following several rounds of mass drug administration .", "sentence_id": 8}
+{"abstract_id": "25201533", "label": "objective", "text": "To evaluate the efficacy of a large capsulorhexis and intraocular lens ( IOL ) in obtaining a larger anterior capsule opening after cataract surgery in patients with diabetes mellitus ( DM ) .", "sentence_id": 0}
+{"abstract_id": "25201533", "label": "methods", "text": "Department of Ophthalmology , University of Fukui , Fukui , Japan .", "sentence_id": 1}
+{"abstract_id": "25201533", "label": "methods", "text": "Prospective clinical trial .", "sentence_id": 2}
+{"abstract_id": "25201533", "label": "methods", "text": "Patients with DM had bilateral cataract surgery with a @ or @ mm scleral incision , a capsulorhexis with a diameter of approximately @ or @ mm , and implantation of a @ mm optic ( Eternity X-@ ) or @ mm optic ( Eternity X-@ ) IOL .", "sentence_id": 3}
+{"abstract_id": "25201533", "label": "methods", "text": "The anterior capsule opening area , aqueous flare intensity , surgically induced astigmatism ( SIA ) , corneal endothelial cell density ( ECD ) , and central corneal thickness ( CCT ) were measured @ day , @ week , and @ , @ , and @ months after surgery .", "sentence_id": 4}
+{"abstract_id": "25201533", "label": "results", "text": "Thirty-one patients ( @ eyes ) with DM were enrolled .", "sentence_id": 5}
+{"abstract_id": "25201533", "label": "results", "text": "At all postoperative timepoints , the anterior capsule opening was significantly larger in eyes with the @ mm optic IOL than in eyes with the @ mm optic IOL ( P < @ , Mann-Whitney U test ) .", "sentence_id": 6}
+{"abstract_id": "25201533", "label": "results", "text": "There were no significant differences in postoperative aqueous flare intensity , SIA , ECD , or CCT based on the size of the capsulorhexis and IOL .", "sentence_id": 7}
+{"abstract_id": "25201533", "label": "conclusions", "text": "A larger capsulorhexis and implantation of a @ mm IOL resulted in a larger anterior capsule opening after cataract surgery in patients with DM .", "sentence_id": 8}
+{"abstract_id": "25056567", "label": "objective", "text": "We sought to determine the dose-response effects of extended-release ( ER ) dexmethylphenidate ( d-MPH ) and ER mixed amphetamine salts ( MAS ) on objective measures of sleep .", "sentence_id": 0}
+{"abstract_id": "25056567", "label": "methods", "text": "This was an @-week , double-blind , placebo-controlled , randomized , two period , crossover study of youth with attention-deficit hyperactivity disorder ( ADHD ) as confirmed by the Kiddie Schedule for Affective Disorders for School-Age Children-Present and Lifetime version ( K-SADS-PL ) .", "sentence_id": 1}
+{"abstract_id": "25056567", "label": "methods", "text": "Children aged @-@ years were recruited from clinical practice , colleague referrals , and flyers .", "sentence_id": 2}
+{"abstract_id": "25056567", "label": "methods", "text": "Participants were randomized to initially receive either d-MPH or MAS .", "sentence_id": 3}
+{"abstract_id": "25056567", "label": "methods", "text": "During each @-week drug period , children received three dose levels ( @ , @ , and @/@mg ) in ascending order , with placebo substituted for active medication in a randomized fashion during @week of the study .", "sentence_id": 4}
+{"abstract_id": "25056567", "label": "methods", "text": "After @weeks , participants were switched to the alternative medication for another @weeks of treatment .", "sentence_id": 5}
+{"abstract_id": "25056567", "label": "methods", "text": "The main outcome measure was sleep duration as measured by actigraphy .", "sentence_id": 6}
+{"abstract_id": "25056567", "label": "methods", "text": "Children , parents , and researchers were blinded to drug , dose , and placebo status .", "sentence_id": 7}
+{"abstract_id": "25056567", "label": "results", "text": "Sixty-five participants met the inclusion criteria and were enrolled in the study .", "sentence_id": 8}
+{"abstract_id": "25056567", "label": "results", "text": "Of these , @ participants with sufficient sleep data for analysis were included .", "sentence_id": 9}
+{"abstract_id": "25056567", "label": "results", "text": "Sleep schedule measures showed a significant effect for dose on sleep start time ( F ( @,@ ) = @ ; p < @ ) , with a significantly later sleep start time when children were receiving @ - or @-mg doses , compared with placebo ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25056567", "label": "results", "text": "A significant dose effect was found on actual sleep duration ( F ( @,@ ) = @ ; p < @ ) , with significantly shorter actual sleep duration for subjects receiving @mg compared with those receiving placebo ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25056567", "label": "results", "text": "There were no significant differences on sleep duration or sleep schedule between the two stimulant medications .", "sentence_id": 12}
+{"abstract_id": "25056567", "label": "results", "text": "The trial is complete and closed to follow-up .", "sentence_id": 13}
+{"abstract_id": "25056567", "label": "conclusions", "text": "Higher stimulant doses were associated with reduced sleep duration and later sleep start times , regardless of medication class .", "sentence_id": 14}
+{"abstract_id": "25366886", "label": "background", "text": "Survival rates after sudden cardiac arrest could be increased if bystanders could be encouraged to perform CPR until emergency services arrive .", "sentence_id": 0}
+{"abstract_id": "25366886", "label": "background", "text": "This should be initiated by the dispatcher at the emergency control facility who receives the call .", "sentence_id": 1}
+{"abstract_id": "25366886", "label": "background", "text": "For the first time the ERC guidelines of @ included instructions to be given to untrained rescuers by the dispatcher .", "sentence_id": 2}
+{"abstract_id": "25366886", "label": "background", "text": "Rapid recognition of cardiac arrest and initiation of emergency measures is assured by means of specific training for the dispatchers .", "sentence_id": 3}
+{"abstract_id": "25366886", "label": "objective", "text": "The aim of this investigation was to determine whether the time between an emergency call and beginning of cardiopulmonary resuscitation ( CPR ) could be shortened using a simple protocol and whether a relationship exists between the intensity of phone contact between dispatcher and caller and if this improves the results .", "sentence_id": 4}
+{"abstract_id": "25366886", "label": "methods", "text": "In known cases of unconsciousness , group @ ( @ persons ) received short CPR instructions via the phone , where the dispatcher was on the phone for continuous advice until emergency services arrived .", "sentence_id": 5}
+{"abstract_id": "25366886", "label": "methods", "text": "Group @ ( @ persons ) received identical phone instructions like group @ , but the phone call was terminated by the dispatcher after the information was provided .", "sentence_id": 6}
+{"abstract_id": "25366886", "label": "methods", "text": "Group @ ( @ persons ) only received instructions to start CPR .", "sentence_id": 7}
+{"abstract_id": "25366886", "label": "results", "text": "On average , all test persons in group @ started reanimation after @ s , in group @ after @ s , and in group @ after @ s.", "sentence_id": 8}
+{"abstract_id": "25366886", "label": "results", "text": "The compression frequency on average was @ / min in group @ , @ / min in group @ , and @ / min in group @ ; therefore , all groups reached an average frequency of > @/min .", "sentence_id": 9}
+{"abstract_id": "25366886", "label": "results", "text": "The correct compression depth was achieved by @ % of test persons in group @ , by @ % in group @ , and by @ % in group @ .", "sentence_id": 10}
+{"abstract_id": "25366886", "label": "results", "text": "All volunteers felt well supported .", "sentence_id": 11}
+{"abstract_id": "25366886", "label": "results", "text": "Of the @ people , @ did not feel that they were missing instructions .", "sentence_id": 12}
+{"abstract_id": "25366886", "label": "conclusions", "text": "There were no significant differences between the groups regarding the target variables .", "sentence_id": 13}
+{"abstract_id": "25366886", "label": "conclusions", "text": "The results show that already extremely short instructions or advice by the dispatcher to start CPR is sufficient to encourage bystanders to give assistance in an emergency .", "sentence_id": 14}
+{"abstract_id": "25366886", "label": "conclusions", "text": "Continuous support over the phone does not appear to be necessary .", "sentence_id": 15}
+{"abstract_id": "24727030", "label": "objective", "text": "To evaluate the effects of peritoneal cold nebulization of ropivacaine on pain control after gynecologic laparoscopy .", "sentence_id": 0}
+{"abstract_id": "24727030", "label": "methods", "text": "Evidence obtained from a properly designed , randomized , double-blind , placebo-controlled trial ( Canadian Task Force classification I ) .", "sentence_id": 1}
+{"abstract_id": "24727030", "label": "methods", "text": "Tertiary care center .", "sentence_id": 2}
+{"abstract_id": "24727030", "label": "methods", "text": "One hundred thirty-five women with American Society of Anesthesiologists disease classified as ASA I-III who were scheduled to undergo operative laparoscopy .", "sentence_id": 3}
+{"abstract_id": "24727030", "label": "methods", "text": "Patients were randomized to receive either nebulization of @ mg ropivacaine before surgery ( preoperative group ) , nebulization of @ mg ropivacaine after surgery ( postoperative group ) , instillation of @ mg ropivacaine before surgery ( instillation group ) , or instillation of saline solution ( control group ) .", "sentence_id": 4}
+{"abstract_id": "24727030", "label": "methods", "text": "Nebulization was performed using the Aeroneb Pro device .", "sentence_id": 5}
+{"abstract_id": "24727030", "label": "results", "text": "Pain scores , morphine consumption , and ambulation time were collected in the post-anesthesia care unit and at @ , @ , and @ hours postoperatively .", "sentence_id": 6}
+{"abstract_id": "24727030", "label": "results", "text": "One hundred eighteen patients completed the study .", "sentence_id": 7}
+{"abstract_id": "24727030", "label": "results", "text": "Patients in the preoperative group reported lower pain Numeric Ranking Scale values compared with those in the control group ( net difference @ points ; @ % confidence interval -LSB- CI -RSB- , @-@ @ at @ hours , @-@ at @ hours , and @-@ at @ hours ; p = @ ) Patients in the preoperative group consumed significantly less morphine than did those in the control group ( net difference @ mg ; @ % CI , @-@ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24727030", "label": "results", "text": "More patients who received nebulization walked without assistance within @ hours after awakening than did those in the instillation and control groups ( net difference @ % ; @ % CI , @ % -@ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24727030", "label": "conclusions", "text": "Cold nebulization of ropivacaine before surgery reduced postoperative pain and morphine consumption and was associated with earlier walking without assistance .", "sentence_id": 10}
+{"abstract_id": "24960387", "label": "objective", "text": "The purpose of this study was to verify the influence of prebrushing mouthwashes on dental plaque removal in children .", "sentence_id": 0}
+{"abstract_id": "24960387", "label": "methods", "text": "This study had a double-blind , randomized , controlled , crossover , @-day experimental design , including @ @ - to @-year-olds .", "sentence_id": 1}
+{"abstract_id": "24960387", "label": "methods", "text": "Four solutions were used as prebrushing mouthwashes ( Colgate Plax Magic , Listerine Cool Blue Agent , water and dye , and water ) by each participant with seven days ' washout .", "sentence_id": 2}
+{"abstract_id": "24960387", "label": "methods", "text": "The plaque index was evaluated before and after tooth-brushing during the experimental period .", "sentence_id": 3}
+{"abstract_id": "24960387", "label": "results", "text": "Intergroup comparisons showed no significant differences in plaque reduction among evaluated solutions ( Friedman test , P > @ ) .", "sentence_id": 4}
+{"abstract_id": "24960387", "label": "results", "text": "Significantly more plaque was present before vs. after tooth-brushing ( Wilcoxon rank test , P < @ ) , independent of the surface ( buccal or lingual/palatal ) .", "sentence_id": 5}
+{"abstract_id": "24960387", "label": "conclusions", "text": "Use of prebrushing mouthwashes by children does not influence plaque removal by tooth-brushing .", "sentence_id": 6}
+{"abstract_id": "25539757", "label": "background", "text": "Treatments of eating disorders result too often in partial psychological and physical remission , chronicization , dropout , relapse and death , with no fully known explanations for this failure .", "sentence_id": 0}
+{"abstract_id": "25539757", "label": "background", "text": "In order to clarify this problem , we conducted three studies to identify the biochemical background of cognitive-behavioural psychotherapy ( CBT ) , individual psychology brief psychotherapy ( IBPP ) , and psychotherapy-pharmacotherapy with CBT + olanzapine in anorexics ( AN ) and bulimics ( BN ) by measuring the levels of plasma homovanillic acid ( HVA ) for dopamine secretion , plasma @-methoxy-@-hydroxy-phenylglycol ( MHPG ) for noradrenalin secretion , and platelet -LSB- @H -RSB- - Paroxetin-binding Bmax and Kd for serotonin transporter function .", "sentence_id": 1}
+{"abstract_id": "25539757", "label": "background", "text": "The data were then compared with psychopathological and physical alterations .", "sentence_id": 2}
+{"abstract_id": "25539757", "label": "methods", "text": "Study @ investigated the effects of @ months of CBT on plasma HVA , MHPG and -LSB- @H -RSB- - Par-binding in @ AN-restricted , @ AN-bingeing/purging , and @ BN inpatients .", "sentence_id": 3}
+{"abstract_id": "25539757", "label": "methods", "text": "Study @ investigated the effects of @ months of IBPP on plasma HVA in @ AN and @ BN outpatients .", "sentence_id": 4}
+{"abstract_id": "25539757", "label": "methods", "text": "Study @ investigated the effect of @ months of CBT + olanzapine ( @ mg/day ) in @ AN outpatients .", "sentence_id": 5}
+{"abstract_id": "25539757", "label": "methods", "text": "The data were analyzed using one-way ANOVA for repeated measures for the changes between basal and post-treatment biological and psychological parameters , two-way ANOVA for repeated measures for the differences in the psychobiological data in the @ groups , Spearman 's test for the correlations between basal and final changes in the psychological and biological scores .", "sentence_id": 6}
+{"abstract_id": "25539757", "label": "results", "text": "Study @ revealed significant amelioration of the psychopathology in the AN and BN patients , no effects on HVA , MHPG or Paroxetin binding Kd , and a significant increase in Par-binding Bmax only in the BN patients .", "sentence_id": 7}
+{"abstract_id": "25539757", "label": "results", "text": "Study @ revealed a significant effect of IBPP on psychopathology in the AN and BN patients , and a significant increase in HVA only in the BN patients .", "sentence_id": 8}
+{"abstract_id": "25539757", "label": "results", "text": "Study @ revealed a significant positive effect of CBT + olanzapine therapy on the psychopathology and increased HVA values .", "sentence_id": 9}
+{"abstract_id": "25539757", "label": "results", "text": "No correlations were observed in the @ groups between biological and psychological effects of the three treatments .", "sentence_id": 10}
+{"abstract_id": "25539757", "label": "conclusions", "text": "Our data advance suggestions on the mechanism of action of the three therapies ; however , the lack of correlations between biochemical and psychological effects casts doubt on their significance .", "sentence_id": 11}
+{"abstract_id": "25539757", "label": "conclusions", "text": "Clinical Trials.gov .", "sentence_id": 12}
+{"abstract_id": "25539757", "label": "conclusions", "text": "Identifier NCT@ .", "sentence_id": 13}
+{"abstract_id": "24435063", "label": "objective", "text": "This study explored the interest in genomic testing for modest changes in colorectal cancer risk and preferences for receiving genomic risk communications among individuals with intermediate disease risk due to a family history of colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "24435063", "label": "methods", "text": "Surveys were conducted on @ men and women at intermediate risk for colorectal cancer enrolled in a randomized trial comparing a remote personalized risk communication intervention ( TeleCARE ) aimed at promoting colonoscopy to a generic print control condition .", "sentence_id": 1}
+{"abstract_id": "24435063", "label": "methods", "text": "Guided by Leventhal 's Common Sense Model of Self-Regulation , we examined demographic and psychosocial factors possibly associated with interest in SNP testing .", "sentence_id": 2}
+{"abstract_id": "24435063", "label": "methods", "text": "Descriptive statistics and logistic regression models were used to identify factors associated with interest in SNP testing and preferences for receiving genomic risk communications .", "sentence_id": 3}
+{"abstract_id": "24435063", "label": "results", "text": "Three-fourths of participants expressed interest in SNP testing for colorectal cancer risk .", "sentence_id": 4}
+{"abstract_id": "24435063", "label": "results", "text": "Testing interest did not markedly change across behavior modifier scenarios .", "sentence_id": 5}
+{"abstract_id": "24435063", "label": "results", "text": "Participants preferred to receive genomic risk communications from a variety of sources : printed materials ( @ % ) , oncologists ( @ % ) , primary-care physicians ( @ % ) , and the web ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "24435063", "label": "results", "text": "Overall , persons who were unmarried ( p = @ ) , younger ( p = @ ) and with greater cancer-related fear ( p = @ ) were more likely to express interest in predictive genomic testing for colorectal cancer risk .", "sentence_id": 7}
+{"abstract_id": "24435063", "label": "results", "text": "In a stratified analysis , cancer-related fear was associated with the interest in predictive genomic testing in the intervention group ( p = @ ) , but not the control group .", "sentence_id": 8}
+{"abstract_id": "24435063", "label": "conclusions", "text": "Individuals with intermediate familial risk for colorectal cancer are highly interested in genomic testing for modest increases in disease risk , specifically unmarried persons , younger age groups and those with greater cancer fear .", "sentence_id": 9}
+{"abstract_id": "25587090", "label": "background", "text": "Despite effective treatments to reduce cardiovascular disease risk , their translation into practice is limited .", "sentence_id": 0}
+{"abstract_id": "25587090", "label": "results", "text": "Using a parallel arm cluster-randomized controlled trial in @ Australian primary healthcare centers , we tested whether a multifaceted quality improvement intervention comprising computerized decision support , audit/feedback tools , and staff training improved ( @ ) guideline-indicated risk factor measurements and ( @ ) guideline-indicated medications for those at high cardiovascular disease risk .", "sentence_id": 1}
+{"abstract_id": "25587090", "label": "results", "text": "Centers had to use a compatible software system , and eligible patients were regular attendees ( Aboriginal and Torres Strait Islander people aged @ years and others aged @ years ) .", "sentence_id": 2}
+{"abstract_id": "25587090", "label": "results", "text": "Patient-level analyses were conducted using generalized estimating equations to account for clustering .", "sentence_id": 3}
+{"abstract_id": "25587090", "label": "results", "text": "Median follow-up for @,@ patients ( mean age , @ years ; @ % men ) was @ months .", "sentence_id": 4}
+{"abstract_id": "25587090", "label": "results", "text": "Mean monthly staff support was < @ hour/site .", "sentence_id": 5}
+{"abstract_id": "25587090", "label": "results", "text": "For the coprimary outcomes , the intervention was associated with improved overall risk factor measurements ( @ % versus @ % risk ratio ; @ ; @ % confidence interval , @-@ @ ; P = @ ) , but there was no significant differences in recommended prescriptions for the high-risk cohort ( n = @,@ ; @ % versus @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25587090", "label": "results", "text": "There were significant treatment escalations ( new prescriptions or increased numbers of medicines ) for antiplatelet ( @ % versus @ % ; P < @ ) , lipid-lowering ( @ % versus @ % ; P < @ ) , and blood pressure-lowering medications ( @ % versus @ % ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25587090", "label": "conclusions", "text": "In Australian primary healthcare settings , a computer-guided quality improvement intervention , requiring minimal support , improved cardiovascular disease risk measurement but did not increase prescription rates in the high-risk group .", "sentence_id": 8}
+{"abstract_id": "25587090", "label": "conclusions", "text": "Computerized quality improvement tools offer an important , albeit partial , solution to improving primary healthcare system capacity for cardiovascular disease risk management .", "sentence_id": 9}
+{"abstract_id": "25527071", "label": "background", "text": "The Centre for the AIDS Programme of Research in South Africa ( CAPRISA ) @ trial demonstrated a @ % reduction in HIV infection , with a @ % HIV reduction in women who used tenofovir gel consistently .", "sentence_id": 0}
+{"abstract_id": "25527071", "label": "background", "text": "A confirmatory trial is expected to report results in early @ .", "sentence_id": 1}
+{"abstract_id": "25527071", "label": "background", "text": "In the interim , we have a unique window of opportunity to prepare for and devise effective strategies for the future policy and programmatic scale-up of tenofovir gel provision .", "sentence_id": 2}
+{"abstract_id": "25527071", "label": "background", "text": "One approach is to integrate tenofovir gel provision into family planning ( FP ) services .", "sentence_id": 3}
+{"abstract_id": "25527071", "label": "background", "text": "The CAPRISA @ implementation trial provides an opportunity to provide post-trial access to tenofovir gel while generating empiric evidence to assess whether integrating tenofovir gel provision into routine FP services can achieve similar levels of adherence as the CAPRISA @ trial .", "sentence_id": 4}
+{"abstract_id": "25527071", "label": "methods", "text": "This is a two-arm , open-label , randomized controlled non-inferiority trial .", "sentence_id": 5}
+{"abstract_id": "25527071", "label": "methods", "text": "A maximum of @ sexually active , HIV-uninfected women aged @ years and older who previously participated in an antiretroviral prevention study will be enrolled from an urban and rural site in KwaZulu-Natal , South Africa .", "sentence_id": 6}
+{"abstract_id": "25527071", "label": "methods", "text": "The anticipated study duration is @ months , with active accrual requiring approximately @ months ( following which an open cohort will be maintained ) and follow-up continuing for approximately @ months .", "sentence_id": 7}
+{"abstract_id": "25527071", "label": "methods", "text": "At each of the two sites , eligible participants will be randomly assigned to receive tenofovir gel through either FP services ( intervention arm ) or through the CAPRISA research clinics ( control arm ) .", "sentence_id": 8}
+{"abstract_id": "25527071", "label": "methods", "text": "As part of the study intervention , a quality improvement approach will be used to assist the FP services to expand their current services to include tenofovir gel provision .", "sentence_id": 9}
+{"abstract_id": "25527071", "label": "conclusions", "text": "This protocol aims to address an important implementation question on whether FP services are able to effectively incorporate tenofovir gel provision for this at-risk group of women in South Africa .", "sentence_id": 10}
+{"abstract_id": "25527071", "label": "conclusions", "text": "Provision of tenofovir gel to the women from the CAPRISA @ trial meets the ethical obligation for post-trial access , and helps identify a potential avenue for future scale-up of microbicides within the public health system of South Africa .", "sentence_id": 11}
+{"abstract_id": "24380989", "label": "background", "text": "Food residue in the remnant stomach after subtotal gastrectomy ( STG ) interferes with endoscopic observation .", "sentence_id": 0}
+{"abstract_id": "24380989", "label": "background", "text": "We investigated whether intravenous erythromycin improves gastric mucosa visualization in patients with STG .", "sentence_id": 1}
+{"abstract_id": "24380989", "label": "methods", "text": "This study was conducted from April @ to October @ as a double-blinded , placebo-controlled , randomized trial .", "sentence_id": 2}
+{"abstract_id": "24380989", "label": "methods", "text": "Patients who received STG with complete resection ( stage T@-@N@M@ ) were included .", "sentence_id": 3}
+{"abstract_id": "24380989", "label": "methods", "text": "Exclusion criteria were diabetes mellitus , neurologic disease , myopathy , recent viral enteritis history , concomitant therapy influencing gastrointestinal motility and severe comorbidity .", "sentence_id": 4}
+{"abstract_id": "24380989", "label": "methods", "text": "Patients were instructed to consume a soft diet for dinner between @ and @ h , and endoscopies were performed between @ and @ h. Patients were assigned randomly to receive either erythromycin ( @ mg in normal saline @ cc ) or placebo saline .", "sentence_id": 5}
+{"abstract_id": "24380989", "label": "methods", "text": "The endoscopy was performed @ min after infusion .", "sentence_id": 6}
+{"abstract_id": "24380989", "label": "methods", "text": "Grade of residual food was rated as follows : G@ , no residual food ; G@ , a small amount of residual food ; G@ , a moderate amount of residual food ; G@ , a moderate amount of residual food that hinders observation of the entire surface , even with body rolling ; G@ , a great amount of residual food such that endoscopic observation is impossible .", "sentence_id": 7}
+{"abstract_id": "24380989", "label": "results", "text": "When good visibility was defined as G@ + G@ , visibility was significantly better in the erythromycin group ( @ + @ % ) than in the placebo group ( @ + @ % , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24380989", "label": "results", "text": "However , this effect was not seen in patients within @ months after gastrectomy .", "sentence_id": 9}
+{"abstract_id": "24380989", "label": "results", "text": "The risk factor for food stasis in the placebo group ( n = @ ) was food stasis at last endoscopy .", "sentence_id": 10}
+{"abstract_id": "24380989", "label": "results", "text": "The only factor predicting erythromycin response in the erythromycin group ( n = @ ) was elapsed time since surgery .", "sentence_id": 11}
+{"abstract_id": "24380989", "label": "results", "text": "Adverse effects included nausea -LSB- @ ( @ % ) -RSB- and vomiting -LSB- @ ( @ % ) -RSB- in the erythromycin group and vomiting -LSB- @ ( @ % ) -RSB- in the placebo group .", "sentence_id": 12}
+{"abstract_id": "24380989", "label": "results", "text": "However , they were transient and tolerable .", "sentence_id": 13}
+{"abstract_id": "24380989", "label": "conclusions", "text": "Premedication with erythromycin improves mucosal visualization during endoscopy in patients with STG .", "sentence_id": 14}
+{"abstract_id": "24285617", "label": "objective", "text": "To test the hypothesis that daily acute intermittent hypoxia ( dAIH ) and dAIH combined with overground walking improve walking speed and endurance in persons with chronic incomplete spinal cord injury ( iSCI ) .", "sentence_id": 0}
+{"abstract_id": "24285617", "label": "methods", "text": "Nineteen subjects completed the randomized , double-blind , placebo-controlled , crossover study .", "sentence_id": 1}
+{"abstract_id": "24285617", "label": "methods", "text": "Participants received @ , @-second hypoxic exposures ( dAIH , fraction of inspired oxygen -LSB- Fio@ -RSB- = @ ) or daily normoxia ( dSHAM , Fio@ = @ ) at @-second normoxic intervals on @ consecutive days ; dAIH was given alone or combined with @ minutes of overground walking @ hour later .", "sentence_id": 2}
+{"abstract_id": "24285617", "label": "methods", "text": "Walking speed and endurance were quantified using @-Meter and @-Minute Walk Tests .", "sentence_id": 3}
+{"abstract_id": "24285617", "label": "methods", "text": "The trial is registered at ClinicalTrials.gov ( NCT@ ) .", "sentence_id": 4}
+{"abstract_id": "24285617", "label": "results", "text": "dAIH improved walking speed and endurance .", "sentence_id": 5}
+{"abstract_id": "24285617", "label": "results", "text": "Ten-Meter Walk time improved with dAIH vs dSHAM after @ day ( mean difference -LSB- MD -RSB- @ seconds , @ % confidence interval -LSB- CI -RSB- @-@ @ seconds , p = @ ) and @ weeks ( MD @ seconds , @ % CI @-@ @ seconds , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24285617", "label": "results", "text": "Six-Minute Walk distance increased with combined dAIH + walking vs dSHAM + walking after @ days ( MD @ m , @ % CI @-@ @ m , p = @ ) and @-week follow-up ( MD @ m , @ % CI @-@ @ m , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24285617", "label": "results", "text": "dAIH + walking increased walking distance more than dAIH after @ day ( MD @ m , @ % CI @-@ @ m , p = @ ) , @ days ( MD @ m , @ % CI @-@ @ m , p = @ ) , and @-week follow-up ( MD @ m , @ % CI @-@ @ m , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24285617", "label": "conclusions", "text": "dAIH walking improved walking speed and distance in persons with chronic iSCI .", "sentence_id": 9}
+{"abstract_id": "24285617", "label": "conclusions", "text": "The impact of dAIH is enhanced by combination with walking , demonstrating that combinatorial therapies may promote greater functional benefits in persons with iSCI .", "sentence_id": 10}
+{"abstract_id": "24285617", "label": "methods", "text": "This study provides Class I evidence that transient hypoxia ( through measured breathing treatments ) , along with overground walking training , improves walking speed and endurance after iSCI .", "sentence_id": 11}
+{"abstract_id": "24661817", "label": "background", "text": "Pulmonary coagulopathy is a hallmark of lung injury following inhalation trauma .", "sentence_id": 0}
+{"abstract_id": "24661817", "label": "background", "text": "Locally applied heparin attenuates lung injury in animal models of smoke inhalation .", "sentence_id": 1}
+{"abstract_id": "24661817", "label": "background", "text": "Whether local treatment with heparin benefits patients with inhalation trauma is uncertain .", "sentence_id": 2}
+{"abstract_id": "24661817", "label": "background", "text": "The present trial aims at comparing a strategy using frequent nebulizations of heparin with standard care in intubated and ventilated burn patients with bronchoscopically confirmed inhalation trauma .", "sentence_id": 3}
+{"abstract_id": "24661817", "label": "methods", "text": "The Randomized Controlled Trial Investigating the Efficacy and Safety of Nebulized HEParin versus Placebo in BURN Patients with Inhalation Trauma ( HEPBURN ) is an international multi-center , double-blind , placebo-controlled , two-arm study .", "sentence_id": 4}
+{"abstract_id": "24661817", "label": "methods", "text": "One hundred and sixteen intubated and ventilated burn patients with confirmed inhalation trauma are randomized to nebulizations of heparin ( the nebulized heparin strategy ) or nebulizations of normal saline ( the control strategy ) every four hours for @days or until extubation , whichever comes first .", "sentence_id": 5}
+{"abstract_id": "24661817", "label": "methods", "text": "The primary endpoint is the number of ventilator-free days , defined as days alive and breathing without assistance during the first @days , if the period of unassisted breathing lasts for at least @ consecutive hours .", "sentence_id": 6}
+{"abstract_id": "24661817", "label": "conclusions", "text": "As far as the authors know , HEPBURN is the first randomized , placebo-controlled trial , powered to investigate whether local treatment with heparin shortens duration of ventilation of intubated and ventilated burn patients with inhalation trauma .", "sentence_id": 7}
+{"abstract_id": "25384813", "label": "objective", "text": "People are now living longer , but disability may affect the quality of those additional years of life .", "sentence_id": 0}
+{"abstract_id": "25384813", "label": "objective", "text": "We undertook a trial to assess whether case finding reduces disability among older primary care patients .", "sentence_id": 1}
+{"abstract_id": "25384813", "label": "methods", "text": "We conducted a cluster-randomized trial of the Brief Risk Identification Geriatric Health Tool ( BRIGHT ) among @ primary care practices in New Zealand , assigning them to an intervention or control group .", "sentence_id": 2}
+{"abstract_id": "25384813", "label": "methods", "text": "Intervention practices sent a BRIGHT screening tool to older adults every birthday ; those with a score of @ or higher were referred to regional geriatric services for assessment and , if needed , service provision .", "sentence_id": 3}
+{"abstract_id": "25384813", "label": "methods", "text": "Control practices provided usual care .", "sentence_id": 4}
+{"abstract_id": "25384813", "label": "methods", "text": "Main outcomes , assessed in blinded fashion , were residential care placement and hospitalization , and secondary outcomes were disability , assessed with Nottingham Extended Activities of Daily Living Scale ( NEADL ) , and quality of life , assessed with the World Health Organization Quality of Life scale , abbreviated version ( WHOQOL-BREF ) .", "sentence_id": 5}
+{"abstract_id": "25384813", "label": "results", "text": "All @,@ community-dwelling patients aged @ years and older were approached ; @,@ ( @ % ) participated , of whom @,@ ( @ % ) completed the trial .", "sentence_id": 6}
+{"abstract_id": "25384813", "label": "results", "text": "Their mean age was @ ( SD @ ) years , and @ % were women .", "sentence_id": 7}
+{"abstract_id": "25384813", "label": "results", "text": "Overall , @ % of the intervention group returned a BRIGHT tool ; @ patients were referred .", "sentence_id": 8}
+{"abstract_id": "25384813", "label": "results", "text": "After @ months , patients in the intervention group were more likely than those in the control group to have been placed in residential care : @ % vs @ % ( hazard ratio = @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25384813", "label": "results", "text": "Intervention patients had smaller declines in mean scores for physical health-related quality of life ( @ vs @ points , P = @ ) and psychological health-related quality of life ( @ vs @ points , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25384813", "label": "results", "text": "Hospitalization , disability , and use of services did not differ between groups , however .", "sentence_id": 11}
+{"abstract_id": "25384813", "label": "conclusions", "text": "Our case-finding strategy was effective in increasing identification of older adults with disability , but there was little evidence of improved outcomes .", "sentence_id": 12}
+{"abstract_id": "25384813", "label": "conclusions", "text": "Further research could trial stronger primary care integration strategies .", "sentence_id": 13}
+{"abstract_id": "24434439", "label": "objective", "text": "To investigate the effects of intensive atorvastatin therapy on programmed cell death @ ( PDCD@ ) expression by CD@ + T lymphocytes in patients with unstable angina who received percutaneous coronary intervention ( PCI ) .", "sentence_id": 0}
+{"abstract_id": "24434439", "label": "methods", "text": "Patients with unstable angina were randomized to pretreatment with either an intensive dose ( @ mg/day , n = @ ) or a conventional dose ( @ mg/day , n = @ ) of atorvastatin .", "sentence_id": 1}
+{"abstract_id": "24434439", "label": "methods", "text": "Circulating CD@ + T cells were subsequently obtained prior to PCI , and also @-@ h after PCI , using a magnetic cell sorting system .", "sentence_id": 2}
+{"abstract_id": "24434439", "label": "methods", "text": "Fluorescence-based quantitative real-time PCR was then used to measure levels of PDCD@ mRNA in the isolated CD@ + T lymphocytes , and Western blot analysis was used to detect levels of PDCD@ .", "sentence_id": 3}
+{"abstract_id": "24434439", "label": "methods", "text": "Serum levels of interleukin ( IL ) -@ and TNF - were quantified using enzyme-linked immunosorbent assays .", "sentence_id": 4}
+{"abstract_id": "24434439", "label": "results", "text": "Of the @ patients with unstable angina that were examined , levels of PDCD@ mRNA and protein were found to dramatically decrease in patients who received an intensive dose of atorvastatin following PCI ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24434439", "label": "results", "text": "In contrast , serum levels of TNF - significantly increased following PCI in both the intensive dose group and the conventional dose group , with the latter being higher than the former ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24434439", "label": "results", "text": "Serum IL-@ levels also markedly increased following PCI for the two groups .", "sentence_id": 7}
+{"abstract_id": "24434439", "label": "results", "text": "However , higher values were associated with the intensive dose group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24434439", "label": "conclusions", "text": "Intensive atorvastatin treatment reduced the post-PCI myocardial inflammatory response in patients with unstable angina , possibly by inhibiting PDCD@ expression in CD@ + T lymphocytes .", "sentence_id": 9}
+{"abstract_id": "24400719", "label": "objective", "text": "A randomized and double-blinded study design was implemented to assess the stereo-acuity in patients symmetrically implanted with four types of multifocal intraocular lenses ( MIOLs ) , compared to a monofocal lens ( control group ) .", "sentence_id": 0}
+{"abstract_id": "24400719", "label": "objective", "text": "In addition , the influence of the type of test employed for the evaluation of stereo-acuity was explored .", "sentence_id": 1}
+{"abstract_id": "24400719", "label": "methods", "text": "Six months after cataract intervention , stereo-acuity was measured with the Titmus and TNO stereotests in @ patients implanted with one of the following MIOL lens types : hybrid spherical SN@D@ , hybrid aspheric SN@AD@ , diffractive aspheric ZMA@ and refractive spherical NXG@ .", "sentence_id": 2}
+{"abstract_id": "24400719", "label": "methods", "text": "A control group implanted with the monofocal aspheric ZA@ ( in which stereo-acuity was measured with a near addition ) was also included in the study .", "sentence_id": 3}
+{"abstract_id": "24400719", "label": "results", "text": "Statistically significant better stereo-acuity was found in the monofocal group with both stereotests ( except for the SN@D@ group with the Titmus test ) ( all p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24400719", "label": "results", "text": "No significant differences in stereo-acuity between MIOLs were found using the Titmus test .", "sentence_id": 5}
+{"abstract_id": "24400719", "label": "results", "text": "However , with the TNO , patients implanted with hybrid diffractive MIOLs exhibited statistically significant worse stereo-acuity than those with the refractive design ( SN@D@ , p < @ ; SN@AD@ , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24400719", "label": "conclusions", "text": "Patients implanted with MIOLs have worse stereo-acuity than those implanted with monofocal IOLs due to the decrease in retinal image contrast originating in the simultaneous presence of two images .", "sentence_id": 7}
+{"abstract_id": "24400719", "label": "conclusions", "text": "A wavelength-based stereotest such as the TNO induces large differences in image contrast between fellow eyes implanted with diffractive-based MIOLs , which may result in an underestimation of the real stereo-acuity of the patient .", "sentence_id": 8}
+{"abstract_id": "24552184", "label": "background", "text": "The effectiveness and durability of endovascular revascularization therapies for chronic critical limb ischemia ( CLI ) are challenged by the extensive burden of infrapopliteal arterial disease and lesion-related characteristics ( e.g. , severe calcification , chronic total occlusions ) , which frequently result in poor clinical outcomes .", "sentence_id": 0}
+{"abstract_id": "24552184", "label": "background", "text": "While infrapopliteal vessel patency directly affects pain relief and wound healing , sustained patency and extravascular care both contribute to the ultimate `` patient-centric '' outcomes of functional limb preservation , mobility and quality of life ( QoL ) .", "sentence_id": 1}
+{"abstract_id": "24552184", "label": "methods", "text": "IN.PACT DEEP is a @:@ randomized controlled trial designed to assess the efficacy and safety of infrapopliteal arterial revascularization between the IN.PACT Amphirion paclitaxel drug-eluting balloon ( IA-DEB ) and standard balloon angioplasty ( PTA ) in patients with Rutherford Class @-@-@ CLI .", "sentence_id": 2}
+{"abstract_id": "24552184", "label": "conclusions", "text": "This multicenter trial has enrolled @ patients at @ European centers with independent angiographic core lab adjudication of the primary efficacy endpoint of target lesion late luminal loss ( LLL ) and clinically driven target lesion revascularization ( TLR ) in major amputation-free surviving patients through @-months .", "sentence_id": 3}
+{"abstract_id": "24552184", "label": "conclusions", "text": "An independent wound core lab will evaluate all ischemic wounds to assess the extent of healing and time to healing at @ , @ , and @ months .", "sentence_id": 4}
+{"abstract_id": "24552184", "label": "conclusions", "text": "A QoL questionnaire including a pain scale will assess changes from baseline scores through @ months .", "sentence_id": 5}
+{"abstract_id": "24552184", "label": "conclusions", "text": "A Clinical Events Committee and Data Safety Monitoring Board will adjudicate the composite primary safety endpoints of all-cause death , major amputation , and clinically driven TLR at @ months and other trial endpoints and supervise patient safety throughout the study .", "sentence_id": 6}
+{"abstract_id": "24552184", "label": "conclusions", "text": "All patients will be followed for @ years .", "sentence_id": 7}
+{"abstract_id": "24552184", "label": "conclusions", "text": "A literature review is presented of the current status of endovascular treatment of CLI with drug-eluting balloon and standard PTA .", "sentence_id": 8}
+{"abstract_id": "24552184", "label": "conclusions", "text": "The rationale and design of the IN.PACT DEEP Trial are discussed .", "sentence_id": 9}
+{"abstract_id": "24552184", "label": "conclusions", "text": "IN.PACT DEEP is a milestone , prospective , randomized , robust , independent core lab-adjudicated CLI trial that will evaluate the role of a new infrapopliteal revascularization technology , the IA-DEB , compared to PTA .", "sentence_id": 10}
+{"abstract_id": "24552184", "label": "conclusions", "text": "It will assess the overall impact on infrapopliteal artery patency , limb salvage , wound healing , pain control , QoL , and patient mobility .", "sentence_id": 11}
+{"abstract_id": "24552184", "label": "conclusions", "text": "The @-year results of the adjudicated co-primary and secondary endpoints will be available in @ .", "sentence_id": 12}
+{"abstract_id": "24800582", "label": "objective", "text": "To investigate the efficacy and safety of adjusting the doses of diuretics of different time in the treatment of advanced schistosomiasis ascites .", "sentence_id": 0}
+{"abstract_id": "24800582", "label": "methods", "text": "A total of @ advanced schistosomiasis patients with ascites were randomly divided into an observation group and a control group ( @ cases each ) .", "sentence_id": 1}
+{"abstract_id": "24800582", "label": "methods", "text": "The patients in the observation group received spironolactone and furosemide , and the first doses were @ mg/d and @ mg/d , respectively .", "sentence_id": 2}
+{"abstract_id": "24800582", "label": "methods", "text": "If the efficacy was poor , according to the first doses of the standard increments once every four days , the doses gradually increased to the maximum doses of spironolactone @ mg/d and furosemide @ mg/d , respectively .", "sentence_id": 3}
+{"abstract_id": "24800582", "label": "methods", "text": "The patients in the control group received spironolactone and furosemide , and the first doses were the same as those of the observation group .", "sentence_id": 4}
+{"abstract_id": "24800582", "label": "methods", "text": "If the efficacy was poor , according to the first doses of the standard increments once every seven days , the doses gradually increased to the maximum doses as those of the observation group .", "sentence_id": 5}
+{"abstract_id": "24800582", "label": "methods", "text": "Other conventional treatments were the same in both groups .", "sentence_id": 6}
+{"abstract_id": "24800582", "label": "results", "text": "In both groups , the reductions of the total amount of the weight were ( @ + / - @ ) kg and ( @ + / - @ ) kg respectively ; the time of efficacy beginning was ( @ + / - @ ) days and ( @ + / - @ ) days respectively ; the average daily amounts of weight loss were ( @ + / - @ ) kg and ( @ + / - @ ) kg respectively ; the efficient rates were @ % and @ % respectively ; and there were no significant differences between the two group ( all P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24800582", "label": "results", "text": "However , the time of reduction from moderate ascites to mild ascites was ( @ + / - @ ) days ( @-@ days ) in the observation group and the time was ( @ + / - @ ) days ( @-@ days ) in the control group ( u = @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24800582", "label": "conclusions", "text": "The therapy of diuretic doses adjusted by a four-day cycle is more useful for advanced schistosomiasis patients with ascites .", "sentence_id": 9}
+{"abstract_id": "24710621", "label": "background", "text": "Preclinical studies suggest that stress potentiates cue-induced cocaine seeking and that this effect is more pronounced in females .", "sentence_id": 0}
+{"abstract_id": "24710621", "label": "background", "text": "These findings have not been characterized in clinical populations .", "sentence_id": 1}
+{"abstract_id": "24710621", "label": "objective", "text": "The objectives of this study were to examine the impact a pharmacological stressor , alpha-@ adrenergic receptor antagonist yohimbine , on the subjective , endocrine , and physiologic responses to drug-paired cues cocaine-dependent men and women .", "sentence_id": 2}
+{"abstract_id": "24710621", "label": "methods", "text": "In a double-blind placebo-controlled cross-over study , cocaine-dependent men ( n = @ ) , cocaine-dependent women ( n = @ ) , control men ( n = @ ) , and control women ( n = @ ) received either yohimbine or placebo prior to two cocaine cue exposure sessions .", "sentence_id": 3}
+{"abstract_id": "24710621", "label": "results", "text": "Yohimbine increased ratings of anxiety both before ( p < @ ) and after ( p = @ ) cues , and the post-cue increase in anxiety was more pronounced in women ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24710621", "label": "results", "text": "Yohimbine also significantly increased craving , compared with placebo ( p < @ ) , following the cue presentation , and this effect was greater in women than men ( gender by treatment interaction ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24710621", "label": "results", "text": "Yohimbine also increased salivary cortisol ( p < @ ) and dehydroepiandrosterone ( p = @ ) levels , regardless of diagnostic group .", "sentence_id": 6}
+{"abstract_id": "24710621", "label": "results", "text": "Women had a significantly greater heart rate response following yohimbine as compared with men ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24710621", "label": "conclusions", "text": "Stress may increase the salience of cocaine cues for cocaine-dependent women as compared with men .", "sentence_id": 8}
+{"abstract_id": "24710621", "label": "conclusions", "text": "This suggests gender differences in vulnerability to craving and relapse under stressful conditions .", "sentence_id": 9}
+{"abstract_id": "24613271", "label": "objective", "text": "The effects of nutritional management among other intervention components have not been examined for hip-fractured elderly persons with poor nutritional status .", "sentence_id": 0}
+{"abstract_id": "24613271", "label": "objective", "text": "Accordingly , this study explored the intervention effects of an in-home program using a comprehensive care model that included a nutrition-management component on recovery of hip-fractured older persons with poor nutritional status at hospital discharge .", "sentence_id": 1}
+{"abstract_id": "24613271", "label": "methods", "text": "A secondary analysis of data from a randomized controlled trial with @-month follow-up .", "sentence_id": 2}
+{"abstract_id": "24613271", "label": "methods", "text": "A @-bed medical center in northern Taiwan .", "sentence_id": 3}
+{"abstract_id": "24613271", "label": "methods", "text": "Subjects were included only if they had `` poor nutritional status '' at hospital discharge , including those at risk for malnutrition or malnourished .", "sentence_id": 4}
+{"abstract_id": "24613271", "label": "methods", "text": "The subsample included @ subjects with poor nutritional status in the comprehensive care group , @ in the interdisciplinary care group , and @ in the usual care group .", "sentence_id": 5}
+{"abstract_id": "24613271", "label": "methods", "text": "The @ care models were usual care , interdisciplinary care , and comprehensive care .", "sentence_id": 6}
+{"abstract_id": "24613271", "label": "methods", "text": "Usual care provided no in-home care , interdisciplinary care provided @ months of in-home rehabilitation , and comprehensive care included management of depressive symptoms , falls , and nutrition as well as @ year of in-home rehabilitation .", "sentence_id": 7}
+{"abstract_id": "24613271", "label": "methods", "text": "Data were collected on nutritional status and physical functions , including range of motion , muscle power , proprioception , balance and functional independence , and analyzed using a generalized estimating equation approach .", "sentence_id": 8}
+{"abstract_id": "24613271", "label": "methods", "text": "We also compared patients ' baseline characteristics : demographic characteristics , type of surgery , comorbidities , length of hospital stay , cognitive function , and depression .", "sentence_id": 9}
+{"abstract_id": "24613271", "label": "results", "text": "Patients with poor nutritional status who received comprehensive care were @ times ( @ % confidence interval @-@ @ ) more likely to recover their nutritional status than those who received interdisciplinary and usual care .", "sentence_id": 10}
+{"abstract_id": "24613271", "label": "results", "text": "Furthermore , the comprehensive care model improved the functional independence and balance of patients who recovered their nutritional status over the first year following discharge , but not of those who had not yet recovered .", "sentence_id": 11}
+{"abstract_id": "24613271", "label": "conclusions", "text": "An in-home program using the comprehensive care model with a nutritional component effectively improved the nutritional status of hip-fractured patients with poor nutrition .", "sentence_id": 12}
+{"abstract_id": "24613271", "label": "conclusions", "text": "This comprehensive care intervention more effectively improved recovery of functional independence and balance for patients with recovered nutritional status .", "sentence_id": 13}
+{"abstract_id": "24397361", "label": "objective", "text": "To determine the effect of vaginal progesterone as luteal support on pregnancy outcomes in infertile patients who undergo ovulation induction with gonadotropins and intrauterine insemination ( IUI ) .", "sentence_id": 0}
+{"abstract_id": "24397361", "label": "methods", "text": "Prospective randomized trial .", "sentence_id": 1}
+{"abstract_id": "24397361", "label": "methods", "text": "Tertiary referral center .", "sentence_id": 2}
+{"abstract_id": "24397361", "label": "methods", "text": "About @ patients with primary infertility were treated during @ ovarian stimulation and IUI cycles from February @ to September @ .", "sentence_id": 3}
+{"abstract_id": "24397361", "label": "methods", "text": "All patients underwent ovarian stimulation with gonadotropins combined with IUI .", "sentence_id": 4}
+{"abstract_id": "24397361", "label": "methods", "text": "Patients in the supported group received vaginal micronized progesterone capsules @mg once daily from the day after insemination until next menstruation or continuing for up to @ weeks of pregnancy .", "sentence_id": 5}
+{"abstract_id": "24397361", "label": "methods", "text": "Women allocated in the control group did not receive luteal phase support .", "sentence_id": 6}
+{"abstract_id": "24397361", "label": "methods", "text": "Livebirth rate , clinical pregnancy rate and early miscarriage rate per cycle .", "sentence_id": 7}
+{"abstract_id": "24397361", "label": "results", "text": "Of the @ cycles , a total of @ clinical pregnancies occurred .", "sentence_id": 8}
+{"abstract_id": "24397361", "label": "results", "text": "There were no significant differences between supported with progesterone and unsupported cycle in terms of livebirth rate ( @ % versus @ % , respectively , with a p value = @ ) and clinical pregnancy rate ( @ % compared with @ % in unsupported cycle with a p value = @ ) .", "sentence_id": 9}
+{"abstract_id": "24397361", "label": "results", "text": "An early miscarriage rate of @ % was observed in the supported cycles and @ % in the unsupported cycles , with no significant differences between the groups ( p value = @ ) .", "sentence_id": 10}
+{"abstract_id": "24397361", "label": "conclusions", "text": "In infertile patients treated with mildly ovarian stimulation with recombinant gonadotropins and IUI , luteal phase support with vaginal progesterone is not associated with higher livebirth rate or clinical pregnancy rate compared with patients who did not receive any luteal phase support .", "sentence_id": 11}
+{"abstract_id": "24655871", "label": "background", "text": "Post-burn hyperglycemia leads to graft failure , multiple organ failure , and death .", "sentence_id": 0}
+{"abstract_id": "24655871", "label": "background", "text": "A hyperinsulinemic-euglycemic clamp is used to keep serum glucose between @ and @ mg/dL .", "sentence_id": 1}
+{"abstract_id": "24655871", "label": "background", "text": "Because of frequent hypoglycemic episodes , a less-stringent sliding scale insulin protocol is used to maintain serum glucose levels between @ and @ mg/dL after elevations > @ mg/dL .", "sentence_id": 2}
+{"abstract_id": "24655871", "label": "methods", "text": "We randomized pediatric patients with massive burns into @ groups , patients receiving sliding scale insulin to lower blood glucose levels ( n = @ ) and those receiving no insulin ( n = @ ) , to determine the differences in morbidity and mortality .", "sentence_id": 3}
+{"abstract_id": "24655871", "label": "methods", "text": "Patients @ to @ years old with burns covering @ % of the total body surface area and not randomized to receive anabolic agents were included in this study .", "sentence_id": 4}
+{"abstract_id": "24655871", "label": "methods", "text": "End points included glucose levels , infections , resting energy expenditure , lean body mass , bone mineral content , fat mass , muscle strength , and serum inflammatory cytokines , hormones , and liver enzymes .", "sentence_id": 5}
+{"abstract_id": "24655871", "label": "results", "text": "Maximal glucose levels occurred within @ days of burn injury .", "sentence_id": 6}
+{"abstract_id": "24655871", "label": "results", "text": "Blood glucose levels were age dependent , with older children requiring more insulin ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24655871", "label": "results", "text": "Daily maximum and daily minimum , but not @ am , glucose levels were significantly different based on treatment group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24655871", "label": "results", "text": "Insulin significantly increased resting energy expenditure and improved bone mineral content ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24655871", "label": "results", "text": "Each additional wound infection increased incidence of hyperglycemia ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24655871", "label": "results", "text": "There was no mortality in patients not receiving insulin , only in patients who received insulin ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "24655871", "label": "results", "text": "Muscle strength was increased in patients receiving insulin ( p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24655871", "label": "conclusions", "text": "Burn-induced hyperglycemia develops in a subset of severely burned children .", "sentence_id": 13}
+{"abstract_id": "24655871", "label": "conclusions", "text": "Length of stay was reduced in the no insulin group , and there were no deaths in this group .", "sentence_id": 14}
+{"abstract_id": "24655871", "label": "conclusions", "text": "Administration of insulin positively impacted bone mineral content and muscle strength , but increased resting energy expenditure , hypoglycemic episodes , and mortality .", "sentence_id": 15}
+{"abstract_id": "24655871", "label": "conclusions", "text": "New glucose-lowering strategies might be needed .", "sentence_id": 16}
+{"abstract_id": "25815578", "label": "objective", "text": "To determine the pharmacokinetics of doxycycline hyclate administered orally in the form of experimental formulations with different proportions of acrylic acid-polymethacrylate-based matrices .", "sentence_id": 0}
+{"abstract_id": "25815578", "label": "methods", "text": "@ healthy adult dogs .", "sentence_id": 1}
+{"abstract_id": "25815578", "label": "methods", "text": "In a crossover study , dogs were randomly assigned ( in groups of @ ) to receive a single oral dose ( @ mg/kg ) of doxycycline hyclate without excipients ( control ) or extended-release formulations ( ERFs ) containing doxycycline , acrylic acid polymer , and polymethacrylate in the following proportions : @:@:@ ( ERF@ ) or @:@:@ ( ERF@ ) .", "sentence_id": 2}
+{"abstract_id": "25815578", "label": "methods", "text": "Serum concentrations of doxycycline were determined for pharmacokinetic analysis before and at several intervals after each treatment .", "sentence_id": 3}
+{"abstract_id": "25815578", "label": "results", "text": "Following oral administration to the study dogs , each ERF resulted in therapeutic serum doxycycline concentrations for @ hours , whereas the control treatment resulted in therapeutic serum doxycycline concentrations for only @ hours .", "sentence_id": 4}
+{"abstract_id": "25815578", "label": "results", "text": "All pharmacokinetic parameters for ERF@ and ERF@ were significantly different ; however , findings for ERF@ did not differ significantly from those for the control treatment .", "sentence_id": 5}
+{"abstract_id": "25815578", "label": "conclusions", "text": "Results indicated that both ERFs containing doxycycline , acrylic acid polymer , and polymethacrylate had an adequate pharmacokinetic-pharmacodynamic relationship for a time-dependent drug and a longer release time than doxycycline alone following oral administration in dogs .", "sentence_id": 6}
+{"abstract_id": "25815578", "label": "conclusions", "text": "Given the minimum effective serum doxycycline concentration of @ g/mL , a dose interval of @ hours can be achieved for each tested ERF .", "sentence_id": 7}
+{"abstract_id": "25815578", "label": "conclusions", "text": "This minimum inhibitory concentration has the potential to be effective against several susceptible bacteria involved in important infections in dogs .", "sentence_id": 8}
+{"abstract_id": "25815578", "label": "conclusions", "text": "Treatment of dogs with either ERF may have several benefits over treatment with doxycycline alone .", "sentence_id": 9}
+{"abstract_id": "24962527", "label": "background", "text": "This study compared mid-term functional and radiologic results of syndesmotic transfixation with no fixation in supination external rotation ( SER ) ankle fractures with intraoperatively confirmed syndesmosis disruption .", "sentence_id": 0}
+{"abstract_id": "24962527", "label": "background", "text": "Our hypothesis was that early-stage good functional results would remain and unfixed syndesmosis disruption in SER IV ankle fractures would not lead to an increased incidence of osteoarthritis .", "sentence_id": 1}
+{"abstract_id": "24962527", "label": "methods", "text": "A prospective study of @ operatively treated patients with Lauge-Hansen SER IV ( Weber B ) ankle fractures was performed .", "sentence_id": 2}
+{"abstract_id": "24962527", "label": "methods", "text": "After bony fixation , the @-Nm standardized external rotation stress test for both ankles was performed under fluoroscopy .", "sentence_id": 3}
+{"abstract_id": "24962527", "label": "methods", "text": "A positive stress examination was defined as a difference of more than @ mm side-to-side in the tibiotalar or tibiofibular clear spaces on mortise radiographs .", "sentence_id": 4}
+{"abstract_id": "24962527", "label": "methods", "text": "The patients were randomized to either syndesmotic screw fixation ( @ patients ) or no syndesmotic fixation ( @ patients ) .", "sentence_id": 5}
+{"abstract_id": "24962527", "label": "methods", "text": "After a minimum of @ years of follow-up ( mean , @ months ) , ankle function and pain ( Olerud-Molander , a @-mm visual analogue scale -LSB- VAS -RSB- for ankle function and pain ) and quality of life ( RAND-@ ) of all @ patients were assessed .", "sentence_id": 6}
+{"abstract_id": "24962527", "label": "methods", "text": "Ankle joint congruity and osteoarthritis were assessed using mortise and lateral projection plain weight-bearing radiographs and magnetic resonance imaging ( MRI ; @T ) scans .", "sentence_id": 7}
+{"abstract_id": "24962527", "label": "results", "text": "Improvement in Olerud-Molander score , VAS , and RAND-@ showed no significant difference between groups during the follow-up .", "sentence_id": 8}
+{"abstract_id": "24962527", "label": "results", "text": "In the syndesmotic transfixation group , improvements in all functional parameters and pain measurements were not significant , whereas in the group without syndesmotic fixation , the Olerud-Molander score improved from @ to @ ( P = @ ) and the pain ( VAS ) score improved from @ to @ ( P = @ ) from @ year to last follow-up .", "sentence_id": 9}
+{"abstract_id": "24962527", "label": "results", "text": "X-ray or MRI imaging showed no difference between groups at the last follow-up visit .", "sentence_id": 10}
+{"abstract_id": "24962527", "label": "conclusions", "text": "With the numbers available , no significant difference in functional outcome or radiologic findings could be detected between syndesmosis transfixation and no-fixation patients with SER IV ankle fracture after a minimum of @ years of follow-up .", "sentence_id": 11}
+{"abstract_id": "24962527", "label": "methods", "text": "Level II , prospective comparative study .", "sentence_id": 12}
+{"abstract_id": "24377217", "label": "objective", "text": "To observe the impacts on post-stroke spastic hemiplegia treated with temporal three-needle therapy , spastic three-needle therapy , and rehabilitative therapy as well as combined application .", "sentence_id": 0}
+{"abstract_id": "24377217", "label": "methods", "text": "One hundred cases were randomized into a Jin 's three-needle group ( @ cases ) , a rehabilitation group ( @ cases ) and a combined therapy group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24377217", "label": "methods", "text": "Beside the basic treatment , the acupuncture therapy of temporal three-needle and spastic three-needle techniques , rehabilitation training , and the combined therapy of acupuncture and rehabilitation were applied in the Jin 's three-needle group , the rehabilitation group and the combined therapy group , respectively .", "sentence_id": 2}
+{"abstract_id": "24377217", "label": "methods", "text": "Before treatment , in @ days and @ days of treatment , the functional comprehensive assessment scale ( FCA ) , clinical neurological defect score ( NDS ) , four-limb simplified Fugl-Meyer assessment ( FMA ) and clinical spasm index ( CSI ) were adopted to assess the spastic degree and limb function , respectively .", "sentence_id": 3}
+{"abstract_id": "24377217", "label": "results", "text": "In terms of FCA , NDS and FMA , in @ days of treatment , except the rehabilitation group , the results in the other two groups were all improved as compared with those before treatment ( all P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24377217", "label": "results", "text": "The results in the Jin 's three-needle group and the combined therapy group were better than those in the rehabilitation group ( all P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24377217", "label": "results", "text": "In @ days of treatment , the results in the three groups were improved as compared with those before treatment and in @ days of treatment ( P < @ , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24377217", "label": "results", "text": "The results in the combined therapy group were better than those in the other two groups ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24377217", "label": "results", "text": "Regarding CSI assessment , in @ days of treatment , the results of the three groups were all improved significantly as compared with those before treatment ( P < @ , P < @ ) , and the results in the combined therapy group were better than those in the other two groups ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24377217", "label": "results", "text": "In @ days of treatment , CSI scores were further improved in the three groups , but the difference was not significant in comparison ( all P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24377217", "label": "conclusions", "text": "The Jin 's three-needle therapy , rehabilitation therapy and the combined application all relieve the symptoms of post-stroke spastic hemiplegia .", "sentence_id": 10}
+{"abstract_id": "24377217", "label": "conclusions", "text": "The effect in the Jin 's three-needle group and the combined therapy group is achieved in @ days of treatment , which is better than that in the rehabilitation group .", "sentence_id": 11}
+{"abstract_id": "24377217", "label": "conclusions", "text": "The combined therapy a chieves the best effect on spasm in comparison with the single therapy .", "sentence_id": 12}
+{"abstract_id": "24386900", "label": "background", "text": "The ` Older People 's Exercise intervention in Residential and nursing Accommodation ' ( OPERA ) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly , physiotherapist-led exercise classes on depressive symptoms in care home residents , but found no effect .", "sentence_id": 0}
+{"abstract_id": "24386900", "label": "background", "text": "We report a process evaluation exploring potential explanations for the lack of effect .", "sentence_id": 1}
+{"abstract_id": "24386900", "label": "methods", "text": "The OPERA trial included over @,@ residents in @ care homes in the UK .", "sentence_id": 2}
+{"abstract_id": "24386900", "label": "methods", "text": "We used a mixed methods approach including quantitative data collected from all homes .", "sentence_id": 3}
+{"abstract_id": "24386900", "label": "methods", "text": "In eight case study homes , we carried out repeated periods of observation and interviews with residents , care staff and managers .", "sentence_id": 4}
+{"abstract_id": "24386900", "label": "methods", "text": "At the end of the intervention , we held focus groups with OPERA research staff .", "sentence_id": 5}
+{"abstract_id": "24386900", "label": "methods", "text": "We reported our first findings before the trial outcome was known .", "sentence_id": 6}
+{"abstract_id": "24386900", "label": "results", "text": "Homes showed large variations in activity at baseline and throughout the trial .", "sentence_id": 7}
+{"abstract_id": "24386900", "label": "results", "text": "Overall attendance rate at the group exercise sessions was low ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24386900", "label": "results", "text": "We considered two issues that might explain the negative outcome : whether the intervention changed the culture of the homes , and whether the residents engaged with the intervention .", "sentence_id": 9}
+{"abstract_id": "24386900", "label": "results", "text": "We found low levels of staff training , few home champions for the intervention and a culture that prioritised protecting residents from harm over encouraging activity .", "sentence_id": 10}
+{"abstract_id": "24386900", "label": "results", "text": "The trial team delivered @,@ exercise groups but only @ % of participants attended at least @ group per week and depressed residents attended significantly fewer groups than those who were not depressed .", "sentence_id": 11}
+{"abstract_id": "24386900", "label": "results", "text": "Residents were very frail and therefore most groups only included seated exercises .", "sentence_id": 12}
+{"abstract_id": "24386900", "label": "conclusions", "text": "The intervention did not change the culture of the homes and , in the case study homes , activity levels did not change outside the exercise groups .", "sentence_id": 13}
+{"abstract_id": "24386900", "label": "conclusions", "text": "Residents did not engage in the exercise groups at a sufficient level , and this was particularly true for those with depressive symptoms at baseline .", "sentence_id": 14}
+{"abstract_id": "24386900", "label": "conclusions", "text": "The physical and mental frailty of care home residents may make it impossible to deliver a sufficiently intense exercise intervention to impact on depressive symptoms .", "sentence_id": 15}
+{"abstract_id": "24330983", "label": "objective", "text": "To compare the effect of different types and concentrations of sweet solutions on neonatal pain during heel lance procedure .", "sentence_id": 0}
+{"abstract_id": "24330983", "label": "methods", "text": "Totally @ full term neonates ( male @ , female @ ) were randomized into @ groups : placebo group ( plain water ) , @ % glucose , @ % glucose , @ % glucose , @ % sucrose , @ % sucrose and @ % sucrose groups.In each group , @ ml corresponding oral solutions were administered through a syringe by dripping into the neonate 's mouth @ minute before heel lance .", "sentence_id": 1}
+{"abstract_id": "24330983", "label": "methods", "text": "The procedure process was recorded by videos , from which to collect heart rate , oxygen saturation and pain score @ min before puncture , @ , @ and @ min after puncture .", "sentence_id": 2}
+{"abstract_id": "24330983", "label": "results", "text": "The average heart rate increase @ , @ and @ min after procedure in the @ % and @ % glucose groups , @ % and @ % and @ % sucrose groups was significantly lower than those in the placebo group ( P < @ or @ ) .", "sentence_id": 3}
+{"abstract_id": "24330983", "label": "results", "text": "The average heart rate increase @ min after procedure in the sucrose group was lower than that in the glucose group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24330983", "label": "results", "text": "Neonates who received @ % sucrose has a significantly lower average heart rate increase than those who received @ % and @ % sucrose @ min after heel lance ( both P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24330983", "label": "results", "text": "The average oxygen saturation decrease @ , @ , @ min after procedure was significantly lower than those in the placebo group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24330983", "label": "results", "text": "The average oxygen saturation decrease @ min after procedure in the sucrose groups was significantly lower than that in the glucose groups ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24330983", "label": "results", "text": "The average pain score @ , @ , @ min after procedure was significantly lower than those in the placebo group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24330983", "label": "results", "text": "The average pain score @ min after procedure in the sucrose groups was significantly lower than that in the glucose groups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24330983", "label": "conclusions", "text": "Oral administration of sweet solutions is an effective way to relieve neonatal pain on procedure , and sucrose has a better pain relief action than glucose , moreover , @ % sucrose provides better effect in control of heart rate increase @ min after heel lance , but the best concentration of sucrose for pain relief needs further study .", "sentence_id": 10}
+{"abstract_id": "25287828", "label": "objective", "text": "To compare epirubicin , cisplatin , and capecitabine ( ECX ) with fluorouracil , leucovorin , and irinotecan ( FOLFIRI ) as first-line treatments in patients with advanced gastric or esophagogastric junction ( EGJ ) adenocarcinoma .", "sentence_id": 0}
+{"abstract_id": "25287828", "label": "methods", "text": "This open , randomized , phase III study was carried out in @ centers .", "sentence_id": 1}
+{"abstract_id": "25287828", "label": "methods", "text": "Patients with locally advanced or metastatic gastric or EGJ cancer were randomly assigned to receive either ECX as first-line treatment ( ECX arm ) or FOLFIRI ( FOLFIRI arm ) .", "sentence_id": 2}
+{"abstract_id": "25287828", "label": "methods", "text": "Second-line treatment was predefined ( FOLFIRI for the ECX arm and ECX for the FOLFIRI arm ) .", "sentence_id": 3}
+{"abstract_id": "25287828", "label": "methods", "text": "The primary criterion was time-to-treatment failure ( TTF ) of the first-line therapy .", "sentence_id": 4}
+{"abstract_id": "25287828", "label": "methods", "text": "Secondary criteria were progression-free survival ( PFS ) , overall survival ( OS ) , toxicity , and quality of life .", "sentence_id": 5}
+{"abstract_id": "25287828", "label": "results", "text": "In all , @ patients were included ( median age , @ years ; @ % male ) .", "sentence_id": 6}
+{"abstract_id": "25287828", "label": "results", "text": "After a median follow-up of @ months , median TTF was significantly longer with FOLFIRI than with ECX ( @ v @ months ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25287828", "label": "results", "text": "There was no significant difference between the two groups in median PFS ( @ v @ months ; P = @ ) , median OS ( @ v @ months ; P = @ ) , or response rate ( @ % v @ % ) .", "sentence_id": 8}
+{"abstract_id": "25287828", "label": "results", "text": "First-line FOLFIRI was better tolerated ( overall rate of grade @ to @ toxicity , @ % v @ % ; P < @ ; hematologic adverse events -LSB- AEs -RSB- , @ % v @ % ; P < @ ; nonhematologic AEs : @ % v @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25287828", "label": "conclusions", "text": "FOLFIRI as first-line treatment for advanced gastric and EGJ cancer demonstrated significantly better TTF than did ECX .", "sentence_id": 10}
+{"abstract_id": "25287828", "label": "conclusions", "text": "Other outcome results indicate that FOLFIRI is an acceptable first-line regimen in this setting and should be explored as a backbone regimen for targeted agents .", "sentence_id": 11}
+{"abstract_id": "24758078", "label": "objective", "text": "To observe the effect of Ginkgo Leaves Tablet ( GLT ) on memory quotient ( MQ ) of mild cognitive impairment ( MCI ) patients .", "sentence_id": 0}
+{"abstract_id": "24758078", "label": "methods", "text": "One hundred and thirteen patients were randomly assigned to the control group ( @ cases ) and the treatment group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24758078", "label": "methods", "text": "Patients in the control group received dietetic therapy and physical exercises , while those in the treatment group additionally took GLT , @ mg each time , three times daily .", "sentence_id": 2}
+{"abstract_id": "24758078", "label": "methods", "text": "The treatment course was @ months for all .", "sentence_id": 3}
+{"abstract_id": "24758078", "label": "methods", "text": "The MQ of all the patients was assessed by WMS-RC before treatment , at @-month of treatment , and @-month of treatment .", "sentence_id": 4}
+{"abstract_id": "24758078", "label": "results", "text": "Compared with the control group , the improvement of MQ increased in the treatment group @ and @ year after treatment ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24758078", "label": "results", "text": "The clinical efficiency of MQ obviously increased in the treatment group ( @ % and @ % ) , showing statistical difference when compared with the control group ( @ % and @ % , P < @ , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24758078", "label": "results", "text": "There was statistical difference in added scores of recognition , regeneration , understanding , and recitation test at @-month of treatment and @-month of treatment between the treatment group and the control group ( P < @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24758078", "label": "conclusions", "text": "GLT was effective in improving MQ of MCI patients , especially in improving recognition , regeneration , understanding , and recitation test .", "sentence_id": 8}
+{"abstract_id": "25460259", "label": "objective", "text": "The current study is the first to examine whether reactivation of fear memory prior to exposure therapy reduces relapse in a randomized clinical sample .", "sentence_id": 0}
+{"abstract_id": "25460259", "label": "methods", "text": "In a standardized treatment protocol combining virtual reality and in-vivo exposure , patients underwent a fear reactivation procedure using a virtual spider @ min prior to a virtual reality ( VR ) exposure ( reactivation group : RG , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25460259", "label": "methods", "text": "A control group ( CG , n = @ ) was exposed to a virtual plant @ min prior to the VR exposure .", "sentence_id": 2}
+{"abstract_id": "25460259", "label": "methods", "text": "Outcome measures were a VR spontaneous recovery test ( SRT ) and in-vivo a behavioral avoidance test assessed @ h after VR exposure .", "sentence_id": 3}
+{"abstract_id": "25460259", "label": "methods", "text": "One week later an in-vivo exposure session followed .", "sentence_id": 4}
+{"abstract_id": "25460259", "label": "methods", "text": "Additionally , a follow-up using psychometric assessment was conducted six months after the first session .", "sentence_id": 5}
+{"abstract_id": "25460259", "label": "results", "text": "Both groups benefitted significantly and equally from the combined treatment , and importantly , the SRT revealed no return of fear in both groups .", "sentence_id": 6}
+{"abstract_id": "25460259", "label": "results", "text": "Furthermore , follow-up tests showed long-term treatment effects with no group differences .", "sentence_id": 7}
+{"abstract_id": "25460259", "label": "conclusions", "text": "Due to different study components ( VR treatment and in-vivo ) , we were not able to determine which treatment module was mainly responsible for the long-term treatment effect .", "sentence_id": 8}
+{"abstract_id": "25460259", "label": "conclusions", "text": "Furthermore , no direct measure of memory destabilization was possible in this study .", "sentence_id": 9}
+{"abstract_id": "25460259", "label": "conclusions", "text": "Our treatment package was highly effective in reducing phobic fear up to @ months following treatment .", "sentence_id": 10}
+{"abstract_id": "25460259", "label": "conclusions", "text": "Explicit fear reactivation prior to exposure was not beneficial in VR exposure treatment , possibly due to a failure to induce a memory destabilization or due to an implicit fear reactivation prior to treatment in both groups .", "sentence_id": 11}
+{"abstract_id": "24758164", "label": "background", "text": "Antibiotic prescribing in dentistry accounts for @ % of total antibiotic prescriptions in Scottish primary care .", "sentence_id": 0}
+{"abstract_id": "24758164", "label": "background", "text": "The Scottish Dental Clinical Effectiveness Programme ( SDCEP ) published guidance in April @ ( @nd edition , August @ ) for Drug Prescribing in Dentistry , which aims to assist dentists to make evidence-based antibiotic prescribing decisions .", "sentence_id": 1}
+{"abstract_id": "24758164", "label": "background", "text": "However , wide variation in prescribing persists and the overall use of antibiotics is increasing .", "sentence_id": 2}
+{"abstract_id": "24758164", "label": "methods", "text": "RAPiD is a @-month partial factorial cluster randomised trial conducted in NHS General Dental Practices across Scotland .", "sentence_id": 3}
+{"abstract_id": "24758164", "label": "methods", "text": "Its aim is to compare the effectiveness of individualised audit and feedback ( A&F ) strategies for the translation into practice of SDCEP recommendations on antibiotic prescribing .", "sentence_id": 4}
+{"abstract_id": "24758164", "label": "methods", "text": "The trial uses routinely collected electronic healthcare data in five aspects of its design in order to : identify the study population ; apply eligibility criteria ; carry out stratified randomisation ; generate the trial intervention ; analyse trial outcomes .", "sentence_id": 5}
+{"abstract_id": "24758164", "label": "methods", "text": "Eligibility was determined on contract status and a minimum level of recent NHS treatment provision .", "sentence_id": 6}
+{"abstract_id": "24758164", "label": "methods", "text": "All eligible dental practices in Scotland were simultaneously randomised at baseline either to current audit practice or to an intervention group .", "sentence_id": 7}
+{"abstract_id": "24758164", "label": "methods", "text": "Randomisation was stratified by single-handed/multi-handed practices .", "sentence_id": 8}
+{"abstract_id": "24758164", "label": "methods", "text": "General dental practitioners ( GDPs ) working at intervention practices will receive individualised graphical representations of their antibiotic prescribing rate from the previous @ months at baseline and an update at six months .", "sentence_id": 9}
+{"abstract_id": "24758164", "label": "methods", "text": "GDPs could not be blinded to their practice allocation .", "sentence_id": 10}
+{"abstract_id": "24758164", "label": "methods", "text": "Intervention practices were further randomised using a factorial design to receive feedback with or without : a health board comparator ; a supplementary text-based intervention ; additional feedback at nine months .", "sentence_id": 11}
+{"abstract_id": "24758164", "label": "methods", "text": "The primary outcome is the total antibiotic prescribing rate per @ courses of treatment over the year following delivery of the baseline intervention .", "sentence_id": 12}
+{"abstract_id": "24758164", "label": "methods", "text": "A concurrent qualitative process evaluation will apply theory-based approaches using the Consolidated Framework for Implementation Research to explore the acceptability of the interventions and the Theoretical Domains Framework to identify barriers and enablers to evidence-based antibiotic prescribing behaviour by GDPs .", "sentence_id": 13}
+{"abstract_id": "24758164", "label": "conclusions", "text": "RAPiD will provide a robust evaluation of A&F in dentistry in Scotland .", "sentence_id": 14}
+{"abstract_id": "24758164", "label": "conclusions", "text": "It also demonstrates that linked administrative datasets have the potential to be used efficiently and effectively across all stages of an randomised controlled trial .", "sentence_id": 15}
+{"abstract_id": "26099868", "label": "objective", "text": "To evaluate the efficacy of tramadol , lidocaine , and a combination of tramadol with lidocaine in pain relief using periprostatic nerve block technique by guidance of transrectal ultrasound ( TRUS ) before the prostate biopsy ( PBx ) .", "sentence_id": 0}
+{"abstract_id": "26099868", "label": "methods", "text": "For the indication of TRUS-PBx , the patients with a prostate-specific antigen ( PSA ) level > @ ng/mL or abnormal digital examination findings were selected .", "sentence_id": 1}
+{"abstract_id": "26099868", "label": "methods", "text": "The patients were randomized through random method .", "sentence_id": 2}
+{"abstract_id": "26099868", "label": "methods", "text": "Group @ : patients were administered @ mL of @ % lidocaine ; group @ : patients were administered @ mL of @-mg tramadol ; and group @ : patients were administered @ mL of @ % lidocaine + @-mg tramadol .", "sentence_id": 3}
+{"abstract_id": "26099868", "label": "methods", "text": "The procedures were completed in @ minutes , and a visual pain scale was administered to the patients to question the pain severity .", "sentence_id": 4}
+{"abstract_id": "26099868", "label": "results", "text": "TRUS-guided PBx was performed in @ patients with an age range of @-@ years ( mean age , @ @ years ) and a PSA range of @-@ ng/mL .", "sentence_id": 5}
+{"abstract_id": "26099868", "label": "results", "text": "The mean PSA level of the groups was @ ( @ ) , @ ( @ ) , and @ ( @ ) ng/mL , respectively .", "sentence_id": 6}
+{"abstract_id": "26099868", "label": "results", "text": "The postprocedural pain scores by visual pain scale were @ @ , @ @ , and @ @ in lidocaine , tramadol , and lidocaine + tramadol groups , respectively .", "sentence_id": 7}
+{"abstract_id": "26099868", "label": "conclusions", "text": "Periprostatic nerve block is the current golden standard method owing to pain management and comfort provided , independent of the patient age and the number of core biopsies .", "sentence_id": 8}
+{"abstract_id": "26099868", "label": "conclusions", "text": "We suggest that tramadol may also be used in this field to achieve better pain management by improving lidocaine 's effect or as an alternative to lidocaine .", "sentence_id": 9}
+{"abstract_id": "25525672", "label": "background", "text": "While Web-based interventions have been shown to assist a wide range of patients successfully in managing their illness , few studies have examined the relative contribution of different Web-based components to improve outcomes .", "sentence_id": 0}
+{"abstract_id": "25525672", "label": "background", "text": "Further efficacy trials are needed to test the effects of Web support when offered as a part of routine care .", "sentence_id": 1}
+{"abstract_id": "25525672", "label": "objective", "text": "Our aim was to compare in regular care the effects of ( @ ) an Internet-based patient provider communication service ( IPPC ) , ( @ ) WebChoice , a Web-based illness management system for breast cancer patients ( IPPC included ) , and ( @ ) usual care on symptom distress , anxiety , depression , ( primary outcomes ) , and self-efficacy ( secondary outcome ) .", "sentence_id": 2}
+{"abstract_id": "25525672", "label": "objective", "text": "This study reports preliminary findings from @ months ' follow-up data in a @-month trial .", "sentence_id": 3}
+{"abstract_id": "25525672", "label": "methods", "text": "We recruited @ patients recently diagnosed with breast cancer and undergoing treatment from three Norwegian hospitals .", "sentence_id": 4}
+{"abstract_id": "25525672", "label": "methods", "text": "The nurse-administered IPPC allowed patients to send secure e-messages to and receive e-messages from health care personnel at the hospital where they were treated .", "sentence_id": 5}
+{"abstract_id": "25525672", "label": "methods", "text": "In addition to the IPPC , WebChoice contains components for symptom monitoring , tailored information and self-management support , a diary , and communication with other patients .", "sentence_id": 6}
+{"abstract_id": "25525672", "label": "methods", "text": "A total of @ care providers ( @ nurses , @ physicians , and @ social workers ) were trained to answer questions from patients .", "sentence_id": 7}
+{"abstract_id": "25525672", "label": "methods", "text": "Outcomes were measured with questionnaires at study entry and at study months @ , @ , and @ .", "sentence_id": 8}
+{"abstract_id": "25525672", "label": "methods", "text": "Linear mixed models for repeated measures were fitted to compare effects on outcomes over time .", "sentence_id": 9}
+{"abstract_id": "25525672", "label": "results", "text": "Patients were randomly assigned to the WebChoice group ( n = @ ) , the IPPC group ( n = @ ) , or the usual care group ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "25525672", "label": "results", "text": "Response rates to questionnaires were @ % ( @/@ ) at @ months , @ ( @/@ ) at @ months , and @ % ( @/@ ) at @ months .", "sentence_id": 11}
+{"abstract_id": "25525672", "label": "results", "text": "Attrition was similar in all study groups .", "sentence_id": 12}
+{"abstract_id": "25525672", "label": "results", "text": "Among those with access to WebChoice , @ % ( @/@ ) logged on more than once and @ % ( @/@ ) sent e-messages to care providers .", "sentence_id": 13}
+{"abstract_id": "25525672", "label": "results", "text": "In the IPPC group , @ % ( @/@ ) sent e-messages .", "sentence_id": 14}
+{"abstract_id": "25525672", "label": "results", "text": "Linear mixed models analyses revealed that the WebChoice group reported significantly lower symptom distress ( mean difference @ , @ % CI @-@ @ , P = @ ) , anxiety ( mean difference @ , @ % CI @-@ @ , P = @ ) , and depression ( mean difference @ , @ % CI @-@ @ , P = @ ) compared with the usual care group .", "sentence_id": 15}
+{"abstract_id": "25525672", "label": "results", "text": "The IPPC group reported significant lower depression scores compared with the usual care group ( mean difference @ , @ % CI @-@ @ , P = @ ) , but no differences were observed for symptom distress or anxiety .", "sentence_id": 16}
+{"abstract_id": "25525672", "label": "results", "text": "No significant differences in self-efficacy were found among the study groups .", "sentence_id": 17}
+{"abstract_id": "25525672", "label": "conclusions", "text": "In spite of practice variations and moderate use of the interventions , our results suggest that offering Web support as part of regular care can be a powerful tool to help patients manage their illness .", "sentence_id": 18}
+{"abstract_id": "25525672", "label": "conclusions", "text": "Our finding that a nurse-administered IPPC alone can significantly reduce depression is particularly promising .", "sentence_id": 19}
+{"abstract_id": "25525672", "label": "conclusions", "text": "However , the multicomponent intervention WebChoice had additional positive effects .", "sentence_id": 20}
+{"abstract_id": "24345827", "label": "objective", "text": "The aim of the study was to assess the impact of LYM-X-SORB ( LXS ) , an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis ( CF ) and pancreatic insufficiency ( PI ) .", "sentence_id": 0}
+{"abstract_id": "24345827", "label": "methods", "text": "Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for @ months .", "sentence_id": 1}
+{"abstract_id": "24345827", "label": "methods", "text": "Serum vitamins A ( retinol ) , D ( @-hydroxyvitamin D -LSB- @D -RSB- ) , E ( - tocopherol , - tocopherol : cholesterol ratio ) , and K ( percentage of undercarboxylated osteocalcin -LSB- % ucOC -RSB- and plasma proteins induced by vitamin K absence factor II -LSB- PIVKA II -RSB- ) were assessed at baseline and @ months .", "sentence_id": 2}
+{"abstract_id": "24345827", "label": "methods", "text": "Dietary intake was determined using @-day weighed food records and supplemental vitamin intake by a comprehensive questionnaire .", "sentence_id": 3}
+{"abstract_id": "24345827", "label": "results", "text": "A total of @ subjects ( @ boys , age @ @ years -LSB- mean standard deviation -RSB- ) with complete serum vitamin , dietary and supplemental vitamin data were analyzed .", "sentence_id": 4}
+{"abstract_id": "24345827", "label": "results", "text": "After adjusting for dietary and supplemental vitamin intake , serum retinol increased @ @ g/dL ( coefficient standard error ) ( adjusted R@ = @ , P = @ ) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of -@ % @ % by @ months ( adjusted R@ = @ , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24345827", "label": "results", "text": "These changes occurred in both the LXS and placebo comparison groups .", "sentence_id": 6}
+{"abstract_id": "24345827", "label": "results", "text": "No changes in serum @D or - tocopherol were detected .", "sentence_id": 7}
+{"abstract_id": "24345827", "label": "results", "text": "Both nutrition interventions increased caloric intake a mean of @ @ kcal/day by @ months .", "sentence_id": 8}
+{"abstract_id": "24345827", "label": "conclusions", "text": "Vitamins A and K status improved , whereas vitamins D and E status was unchanged during @ months of LXS and isocaloric placebo comparison supplement in children with CF and PI .", "sentence_id": 9}
+{"abstract_id": "24596458", "label": "background", "text": "The purpose of this study was to assess the effectiveness of a multifactorial intervention to reduce falls among the oldest-old people , including individuals with cognitive impairment or comorbidities .", "sentence_id": 0}
+{"abstract_id": "24596458", "label": "methods", "text": "A randomized , single-blind , parallel-group clinical trial was conducted from January @ to December @ in seven primary health care centers in Baix Llobregat ( Barcelona ) .", "sentence_id": 1}
+{"abstract_id": "24596458", "label": "methods", "text": "Of @ referred people who were born in @ , @ were randomized to an intervention group or a control group .", "sentence_id": 2}
+{"abstract_id": "24596458", "label": "methods", "text": "The intervention model used an algorithm and was multifaceted for both patients and their primary care providers .", "sentence_id": 3}
+{"abstract_id": "24596458", "label": "methods", "text": "Primary outcomes were risk of falling and time until falls .", "sentence_id": 4}
+{"abstract_id": "24596458", "label": "methods", "text": "Data analyses were by intention-to-treat .", "sentence_id": 5}
+{"abstract_id": "24596458", "label": "results", "text": "Sixty-five ( @ % ) subjects in the intervention group and @ ( @ % ) in the control group fell during follow-up .", "sentence_id": 6}
+{"abstract_id": "24596458", "label": "results", "text": "The difference in the risk of falls was not significant ( relative risk @ , @ % confidence interval -LSB- CI -RSB- @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24596458", "label": "results", "text": "Cox regression models with time from randomization to the first fall were not significant .", "sentence_id": 8}
+{"abstract_id": "24596458", "label": "results", "text": "Cox models for recurrent falls showed that intervention had a negative effect ( hazard ratio -LSB- HR -RSB- @ , @ % CI @-@ @ ) and that functional impairment ( HR @ , @ % CI @-@ @ ) , previous falls ( HR @ , @ % CI @-@ @ ) , and cognitive impairment ( HR @ , @ % CI @-@ @ ) had no effect on the assessment .", "sentence_id": 9}
+{"abstract_id": "24596458", "label": "conclusions", "text": "This multifactorial intervention among octogenarians , including individuals with cognitive impairment or comorbidities , did not result in a reduction in falls .", "sentence_id": 10}
+{"abstract_id": "24596458", "label": "conclusions", "text": "A history of previous falls , disability , and cognitive impairment had no effect on the program among the community-dwelling subjects in this study .", "sentence_id": 11}
+{"abstract_id": "24775991", "label": "background", "text": "There is a need to identify novel pharmacologic targets to treat alcoholism .", "sentence_id": 0}
+{"abstract_id": "24775991", "label": "background", "text": "Animal and human studies suggest a role for ghrelin in the neurobiology of alcohol dependence and craving .", "sentence_id": 1}
+{"abstract_id": "24775991", "label": "background", "text": "Here , we were the first to test the hypothesis that intravenous administration of exogenous ghrelin acutely increases alcohol craving .", "sentence_id": 2}
+{"abstract_id": "24775991", "label": "methods", "text": "This was a double-blind , placebo-controlled human laboratory proof-of-concept study .", "sentence_id": 3}
+{"abstract_id": "24775991", "label": "methods", "text": "Nontreatment-seeking , alcohol-dependent , heavy-drinking individuals were randomized to receive intravenous ghrelin @ mcg/kg , @ mcg/kg or @ mcg/kg ( placebo ) , followed by a cue-reactivity procedure , during which participants were exposed to neutral ( juice ) and alcohol cues .", "sentence_id": 4}
+{"abstract_id": "24775991", "label": "methods", "text": "The primary outcome variable was the increase in alcohol craving ( also called urge ) for alcohol , assessed by the Alcohol Visual Analogue Scale .", "sentence_id": 5}
+{"abstract_id": "24775991", "label": "results", "text": "Out of @ screenings , @ individuals received the study drug .", "sentence_id": 6}
+{"abstract_id": "24775991", "label": "results", "text": "Repeated measures of analysis of covariance revealed a group effect across ghrelin doses in increasing alcohol craving ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24775991", "label": "results", "text": "A dose-specific examination revealed a significant effect of ghrelin @ mcg/kg versus placebo in increasing alcohol craving ( p < @ ) with a large effect size ( d = @ ) .", "sentence_id": 8}
+{"abstract_id": "24775991", "label": "results", "text": "By contrast , no significant ghrelin effect was found in increasing either urge to drink juice or food craving ( p = ns ) .", "sentence_id": 9}
+{"abstract_id": "24775991", "label": "results", "text": "No significant differences in side effects were found ( p = ns ) .", "sentence_id": 10}
+{"abstract_id": "24775991", "label": "conclusions", "text": "Intravenous administration of exogenous ghrelin increased alcohol craving in alcohol-dependent heavy-drinking individuals .", "sentence_id": 11}
+{"abstract_id": "24775991", "label": "conclusions", "text": "Although the small sample requires confirmatory studies , these findings provide preliminary evidence that ghrelin may play a role in the neurobiology of alcohol craving , thus demonstrating a novel pharmacologic target for treatment .", "sentence_id": 12}
+{"abstract_id": "24597699", "label": "background", "text": "Various treatments are available for reducible unstable fractures of the distal radius , such as closed reduction combined with fixation by external fixator ( EF ) , and rigid internal fixation using a locked volar plate ( VP ) .", "sentence_id": 0}
+{"abstract_id": "24597699", "label": "background", "text": "Although there are studies comparing these methods , there is no conclusive evidence indicating which treatment is best .", "sentence_id": 1}
+{"abstract_id": "24597699", "label": "background", "text": "The hypothesis of this study is that surgical treatment with a VP is more effective than EF from the standpoint of functional outcome ( patient-reported ) .", "sentence_id": 2}
+{"abstract_id": "24597699", "label": "methods", "text": "The study is randomized clinical trial with parallel groups and a blinded evaluator and involves the surgical interventions EF and VP .", "sentence_id": 3}
+{"abstract_id": "24597699", "label": "methods", "text": "Patients will be randomly assigned ( assignment ratio @:@ ) using sealed opaque envelopes .", "sentence_id": 4}
+{"abstract_id": "24597699", "label": "methods", "text": "This trial will include consecutive adult patients with an acute ( up to @ days ) displaced , unstable fracture of the distal end of the radius of type A@ , A@ , C@ , C@ or C@ by the Arbeitsgemeinschaft fr Osteosynthesefragen-Association for the Study of Internal Fixation classification and type II or type III by the IDEAL@ classification , without previous surgical treatments of the wrist .", "sentence_id": 5}
+{"abstract_id": "24597699", "label": "methods", "text": "The surgical intervention assigned will be performed by three surgical specialists familiar with the techniques described .", "sentence_id": 6}
+{"abstract_id": "24597699", "label": "methods", "text": "Evaluations will be performed at @ , and @ weeks , @ , @ and @ months , with the primary outcomes being measured by the Disabilities of the Arm , Shoulder and Hand ( DASH ) questionnaire and measurement of pain ( Visual Analog Pain Scale and digital algometer ) .", "sentence_id": 7}
+{"abstract_id": "24597699", "label": "methods", "text": "Secondary outcomes will include radiographic parameters , objective functional evaluation ( goniometry and dynamometry ) , and the rate of complications and method failure according to the intention-to-treat principle .", "sentence_id": 8}
+{"abstract_id": "24597699", "label": "methods", "text": "Final postoperative evaluations ( @ and @ months ) will be performed by independent blinded evaluators .", "sentence_id": 9}
+{"abstract_id": "24597699", "label": "methods", "text": "For the Student 's t-test , a difference of @ points in the DASH score , with a @ % confidence interval , a statistical power of @ % , and @ % sampling error results in @ patients per group .", "sentence_id": 10}
+{"abstract_id": "24597699", "label": "conclusions", "text": "Results from this study protocol will improve the current evidence regarding to the surgical treatment these fractures .", "sentence_id": 11}
+{"abstract_id": "25733627", "label": "background", "text": "Excess sodium intake is associated with high blood pressure , a major risk factor for cardiovascular disease ( CVD ) .", "sentence_id": 0}
+{"abstract_id": "25733627", "label": "background", "text": "It is unknown whether decreasing sodium intake to < @ mg/d has an effect on CVD or all-cause mortality .", "sentence_id": 1}
+{"abstract_id": "25733627", "label": "objective", "text": "The objective was to assess whether reductions in sodium intake to < @ mg/d were associated with either an increased or a decreased risk of fatal and nonfatal CVD and all-cause mortality .", "sentence_id": 2}
+{"abstract_id": "25733627", "label": "methods", "text": "This observational prospective study of the PREvencin con DIeta MEDiterrnea ( PREDIMED ) trial included @ participants at high CVD risk .", "sentence_id": 3}
+{"abstract_id": "25733627", "label": "methods", "text": "Sodium intake was evaluated with a validated food-frequency questionnaire and categorized as low ( < @ mg/d ) , intermediate ( @ to @ mg/d ) , high ( > @ to @ mg/d ) , or very high ( > @ mg/d ) .", "sentence_id": 4}
+{"abstract_id": "25733627", "label": "methods", "text": "Subsequently , @-y and @-y changes in sodium intake were calculated .", "sentence_id": 5}
+{"abstract_id": "25733627", "label": "methods", "text": "Multivariate relative risks were assessed by using Cox proportional hazards ratios .", "sentence_id": 6}
+{"abstract_id": "25733627", "label": "methods", "text": "Marginal structural models with inverse probability weighting were used to test the effect of changes in sodium intake and the Mediterranean diet ( MedDiet ) .", "sentence_id": 7}
+{"abstract_id": "25733627", "label": "results", "text": "We documented @ CVD events and @ deaths after a @-y median follow-up .", "sentence_id": 8}
+{"abstract_id": "25733627", "label": "results", "text": "Sodium intake < @ mg/d was associated with a lower risk of all-cause mortality : @ % ( HR : @ ; @ % CI : @ , @ ; P = @ ) and @ % ( HR : @ ; @ % CI : @ , @ ; P = @ ) after @ and @ y , respectively .", "sentence_id": 9}
+{"abstract_id": "25733627", "label": "results", "text": "Increasing sodium intake after @ y was associated with a @ % ( HR : @ ; @ % CI : @ , @ ; P = @ ) higher risk of CVD events .", "sentence_id": 10}
+{"abstract_id": "25733627", "label": "results", "text": "The incidence rate of CVD was reduced for those who reduced their sodium intake and were randomly assigned to MedDiet interventions -LSB- @ / @,@ ( @ % CI : @ , @ ) compared with @ / @,@ ( @ % CI : @ , @ ) person-years ; P = @ -RSB- .", "sentence_id": 11}
+{"abstract_id": "25733627", "label": "conclusions", "text": "Decreasing sodium intake to < @ mg/d was associated with a reduced risk of all-cause mortality , whereas increasing the intake to > @ mg/d was associated with a higher risk of CVD .", "sentence_id": 12}
+{"abstract_id": "25733627", "label": "conclusions", "text": "Our observational data suggest that sodium intake < @ mg/d was associated with an enhanced beneficial effect of the MedDiet on CVD .", "sentence_id": 13}
+{"abstract_id": "25733627", "label": "conclusions", "text": "These results should be interpreted with caution , and other confirmatory studies are necessary .", "sentence_id": 14}
+{"abstract_id": "24952855", "label": "background", "text": "In patients with ST-segment elevation myocardial infarction ( STEMI ) who undergo primary percutaneous coronary intervention ( pPCI ) , the use of dual antiplatelet therapy is essential to prevent atherothrombotic complications .", "sentence_id": 0}
+{"abstract_id": "24952855", "label": "background", "text": "Therefore , patients are treated with acetylsalicylic acid and clopidogrel , prasugrel , or ticagrelor .", "sentence_id": 1}
+{"abstract_id": "24952855", "label": "background", "text": "Clopidogrel , however , shows a major interindividual variation in antiplatelet effect , which is correlated to an increase in atherothrombotic events in patients with high platelet reactivity .", "sentence_id": 2}
+{"abstract_id": "24952855", "label": "background", "text": "This interindividual variation is partly a result of CYP@C@ genetic variants .", "sentence_id": 3}
+{"abstract_id": "24952855", "label": "background", "text": "Ticagrelor and prasugrel reduce atherothrombotic events but increase bleeding rate and drug costs , as compared with clopidogrel .", "sentence_id": 4}
+{"abstract_id": "24952855", "label": "background", "text": "CYP@C@-based tailoring of antiplatelet therapy might be beneficial to STEMI patients .", "sentence_id": 5}
+{"abstract_id": "24952855", "label": "methods", "text": "POPular Genetics ( NCT@ ) is a randomized , open-label , multicenter trial involving @,@ STEMI patients who undergo pPCI .", "sentence_id": 6}
+{"abstract_id": "24952855", "label": "methods", "text": "Patients are randomized to CYP@C@ genotyping or routine ticagrelor or prasugrel treatment .", "sentence_id": 7}
+{"abstract_id": "24952855", "label": "methods", "text": "In the genotyping group , * @ / * @ ( wild-type ) patients receive clopidogrel , and patients carrying @ or @ * @ or * @ loss-of-function alleles receive ticagrelor or prasugrel .", "sentence_id": 8}
+{"abstract_id": "24952855", "label": "methods", "text": "The primary net clinical benefit end point is the composite of death , ( recurrent ) myocardial infarction , definite stent thrombosis , stroke , and Platelet Inhibition and Patient Outcomes ( PLATO ) major bleeding at @ year .", "sentence_id": 9}
+{"abstract_id": "24952855", "label": "methods", "text": "Primary safety end point is the composite of ( PLATO ) major and minor bleeding .", "sentence_id": 10}
+{"abstract_id": "24952855", "label": "methods", "text": "Cost-effectiveness and quality of life will be assessed by calculating quality-adjusted life-years , net costs per life-year , and per quality-adjusted life-year gained .", "sentence_id": 11}
+{"abstract_id": "24952855", "label": "conclusions", "text": "The POPular Genetics study is the first large-scale trial comparing CYP@C@ genotype-guided antiplatelet therapy to a nontailored strategy in terms of net clinical benefit , safety , and cost-effectiveness .", "sentence_id": 12}
+{"abstract_id": "24280999", "label": "background", "text": "Head and neck cancer ( HNC ) patients are prone to have a poor health-related quality of life after cancer treatment .", "sentence_id": 0}
+{"abstract_id": "24280999", "label": "background", "text": "This study investigated the effect of the nurse counselling and after intervention ( NUCAI ) on the health-related quality of life and depressive symptoms of HNC patients between @ and @ months after cancer treatment .", "sentence_id": 1}
+{"abstract_id": "24280999", "label": "methods", "text": "Two hundred and five HNC patients were randomly allocated to NUCAI ( N = @ ) or usual care ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "24280999", "label": "methods", "text": "The @-month nurse-led NUCAI is problem-focused and patient-driven and aims to help HNC patients manage with the physical , psychological and social consequences of their disease and its treatment .", "sentence_id": 3}
+{"abstract_id": "24280999", "label": "methods", "text": "Health-related quality of life was evaluated with the EORTC QLQ-C@ and QLQ H&N @ .", "sentence_id": 4}
+{"abstract_id": "24280999", "label": "methods", "text": "Depressive symptoms were evaluated with the CES-D .", "sentence_id": 5}
+{"abstract_id": "24280999", "label": "results", "text": "At @ months the intervention group showed a significant ( P < @ ) improvement in emotional and physical functioning , pain , swallowing , social contact , mouth opening and depressive symptoms .", "sentence_id": 6}
+{"abstract_id": "24280999", "label": "results", "text": "At @ months , global quality of life , role and emotional functioning , pain , swallowing , mouth opening and depressive symptoms were significantly better in the intervention group than in the control group , and at @ months emotional functioning and fatigue were significantly better in the intervention group .", "sentence_id": 7}
+{"abstract_id": "24280999", "label": "conclusions", "text": "The NUCAI effectively improved several domains of health-related quality of life and depressive symptoms in HNC patients and would seem a promising intervention for implementation in daily clinical practice .", "sentence_id": 8}
+{"abstract_id": "25001020", "label": "objective", "text": "To compare the efficacy and safety of the levonorgestrel-releasing intrauterine device ( LNG-IUD ) with dydrogesterone applied for the same duration in patients having endometrial hyperplasia ( EH ) without atypia .", "sentence_id": 0}
+{"abstract_id": "25001020", "label": "methods", "text": "One hundred thirty eight women aged between @ and @ years with abnormal uterine bleeding and diagnosed as EH by transvaginal ultrasound were randomized to receive either LNG-IUD or dydrogesterone for @ months .", "sentence_id": 1}
+{"abstract_id": "25001020", "label": "methods", "text": "Primary outcome measures were regression of hyperplasia after @ months of therapy .", "sentence_id": 2}
+{"abstract_id": "25001020", "label": "methods", "text": "Secondary outcome measures were occurrence of side effects during treatment or recurrence of hyperplasia during follow-up period .", "sentence_id": 3}
+{"abstract_id": "25001020", "label": "results", "text": "After @ months of treatment , regression of EH occurs in @ % of women in the levonorgestrel-releasing intrauterine system ( LNG-IUS ) group versus @ % of women in the oral group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25001020", "label": "results", "text": "Adverse effects were relatively common with minimal differences between the @ groups .", "sentence_id": 5}
+{"abstract_id": "25001020", "label": "results", "text": "Intermenstrual vaginal spotting and amenorrhea were more common in the LNG-IUD group ( P value @ and @ ) .", "sentence_id": 6}
+{"abstract_id": "25001020", "label": "results", "text": "Patient satisfaction was significantly higher in the LNG-IUS group ( P value @ ) .", "sentence_id": 7}
+{"abstract_id": "25001020", "label": "results", "text": "Hysterectomy rates were lower in the LNG-IUS group than in the oral group ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25001020", "label": "results", "text": "Recurrence rate was @ % in the LNG-IUD group compared to @ % in the oral group .", "sentence_id": 9}
+{"abstract_id": "25001020", "label": "conclusions", "text": "In management of EH without atypia , LNG-IUS achieves a higher regression and a lower hysterectomy rate than oral progesterone and could be used as a first-line therapy .", "sentence_id": 10}
+{"abstract_id": "26427105", "label": "objective", "text": "To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-@ levels .", "sentence_id": 0}
+{"abstract_id": "26427105", "label": "objective", "text": "We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type @ diabetes mellitus and vascular dementia , and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine .", "sentence_id": 1}
+{"abstract_id": "26427105", "label": "methods", "text": "In total , @ patients with type @ diabetes mellitus and vascular dementia were enrolled in the study , and randomly divided into two groups by simple randomization .", "sentence_id": 2}
+{"abstract_id": "26427105", "label": "methods", "text": "Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily , while patients in the control group received pioglitazone hydrochloride alone .", "sentence_id": 3}
+{"abstract_id": "26427105", "label": "methods", "text": "The treatment course was for @ weeks .", "sentence_id": 4}
+{"abstract_id": "26427105", "label": "methods", "text": "Mini-mental state examinations ( Chinese version ) and Montreal Cognitive Assessments ( Beijing version ) were performed , and fasting plasma glucose , fasting insulin , hemoglobin A@c , homeostasis model assessment of insulin resistance , plasma nitric oxide and endothelin-@ levels were measured before and after the treatment .", "sentence_id": 5}
+{"abstract_id": "26427105", "label": "results", "text": "The post-treatment levels for all measurements in both groups were better than pre-treat - ment levels ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "26427105", "label": "results", "text": "The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26427105", "label": "conclusions", "text": "Type @ diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction .", "sentence_id": 8}
+{"abstract_id": "26427105", "label": "conclusions", "text": "Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-@ .", "sentence_id": 9}
+{"abstract_id": "26427105", "label": "conclusions", "text": "Therefore , the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine .", "sentence_id": 10}
+{"abstract_id": "24675241", "label": "objective", "text": "The objectives of this prospective study were to compare the advantages of single-port laparoscopic cholecystectomy ( SPLC ) versus the classical four-port laparoscopic cholecystectomy ( CLC ) and to discuss these advantages in the light of current literature .", "sentence_id": 0}
+{"abstract_id": "24675241", "label": "methods", "text": "Forty eligible patients were randomized to receive SPLC ( Group A , N. = @ ) and CLC ( Group B , N. = @ ) , and investigated with regard to age , sex , BMI ( body mass index ) , ASA ( American Society of Anesthesiologists ) score , type of surgery , operative time , per-operative complication , indication for conversion to open surgery , indication for additional trocar placement in SPLC technique , post-operative pain score , additional narcotic analgesic requirement , nausea and vomiting , post-operative complication and length of hospital stay .", "sentence_id": 1}
+{"abstract_id": "24675241", "label": "methods", "text": "Visual analogue scale ( VAS ) was used for pain scoring in all cases .", "sentence_id": 2}
+{"abstract_id": "24675241", "label": "results", "text": "No significant difference was found among patients in Group A and Group B in terms of age , sex , weight/BMI , ASA score , VAS scores , additional analgesic requirement and length of hospital stay ( P > @ ) .", "sentence_id": 3}
+{"abstract_id": "24675241", "label": "results", "text": "On the other hand , mean operative time in Group A was significantly ( P < @ ) greater than that in Group B. Mean operative time in Group A was observed to be reduced after the first @ operations .", "sentence_id": 4}
+{"abstract_id": "24675241", "label": "results", "text": "Conversion to open surgery was not required in any of the patients ; however , additional trocar placement was required in two patients in Group A due to body habitus and adhesions , and operations were completed laparoscopically .", "sentence_id": 5}
+{"abstract_id": "24675241", "label": "conclusions", "text": "We conclude that SPLC is equally effective as CLC .", "sentence_id": 6}
+{"abstract_id": "24675241", "label": "conclusions", "text": "Patient comfort is increased and pain is decreased as the surgeon gets experienced with the technique .", "sentence_id": 7}
+{"abstract_id": "24560760", "label": "background", "text": "The pediatric diffuse intrinsic pontine glioma ( DIPG ) outcome remains dismal despite multiple therapeutic attempts .", "sentence_id": 0}
+{"abstract_id": "24560760", "label": "objective", "text": "To compare the results of treatment of pediatric diffuse intrinsic pontine glioma ( DIPG ) using hypofractionated versus conventional radiotherapy .", "sentence_id": 1}
+{"abstract_id": "24560760", "label": "methods", "text": "Seventy-one newly diagnosed DIPG children were randomized into hypofractionated ( HF ) ( @Gy/@ fractions in @ weeks ) and conventional ( CF ) arm ( @Gy/@ fractions in @weeks ) .", "sentence_id": 2}
+{"abstract_id": "24560760", "label": "results", "text": "The median and one-year overall survival ( OS ) was @ months and @ % for the hypofractionated arm , and @ and @ % for the conventional arm respectively .", "sentence_id": 3}
+{"abstract_id": "24560760", "label": "results", "text": "The @-month OS difference was @ % .", "sentence_id": 4}
+{"abstract_id": "24560760", "label": "results", "text": "The OS hazard ratio ( HR ) was @ ( @ % CI : @-@ @ ) ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24560760", "label": "results", "text": "The hypofractionated arm had a median and one-year progression-free survival ( PFS ) of @ months and @ % , compared to @ and @ % for the conventional arm .", "sentence_id": 6}
+{"abstract_id": "24560760", "label": "results", "text": "The PFS HR was @ ( @ % CI : @-@ @ ) ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24560760", "label": "results", "text": "The @-month PFS difference was @ % .", "sentence_id": 8}
+{"abstract_id": "24560760", "label": "results", "text": "These differences exceed the non-inferiority margin .", "sentence_id": 9}
+{"abstract_id": "24560760", "label": "results", "text": "The immediate and delayed side effects were not different in the @ arms .", "sentence_id": 10}
+{"abstract_id": "24560760", "label": "conclusions", "text": "Hypofractionated radiotherapy offers lesser burden on the patients , their families and the treating departments , with nearly comparable results to conventional fractionation , though not fulfilling the non-inferiority assumption .", "sentence_id": 11}
+{"abstract_id": "25582984", "label": "objective", "text": "Pregnancy rates in US contraceptive clinical trials are increasing due to decreased treatment compliance .", "sentence_id": 0}
+{"abstract_id": "25582984", "label": "objective", "text": "This study compared compliance with a new low-dose levonorgestrel ( LNG ) and ethinyl estradiol ( EE ) contraceptive patch ( CP , Twirla ) with that of a low-dose combination oral contraceptive ( COC ) in a demographically diverse population .", "sentence_id": 1}
+{"abstract_id": "25582984", "label": "methods", "text": "This analysis was part of an open-label , parallel-group , multicenter phase @ study that randomized healthy sexually active women ( @-@years ) to @cycles of LNG/EE CP or @cycles of COC , then @cycles of LNG/EE CP .", "sentence_id": 2}
+{"abstract_id": "25582984", "label": "methods", "text": "We defined self-reported compliance as cycles that , according to diaries , show @days of patch wear without missed days or any patch worn > @days or @days of pill-taking without missed pill days .", "sentence_id": 3}
+{"abstract_id": "25582984", "label": "methods", "text": "We verified compliance by detectable plasma presence of LNG and EE at cycles @ , @ , and @ .", "sentence_id": 4}
+{"abstract_id": "25582984", "label": "results", "text": "Of the intention-to-treat population with diary information ( N = @ , mean age @ years , @ % minorities , @ % obese ) , @ % of the CP ( n = @ ) versus @ % of the COC group ( n = @ ) self-reported noncompliance after @cycles ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25582984", "label": "results", "text": "Laboratory assessments verified @-@ % of participants in both groups as noncompliant .", "sentence_id": 6}
+{"abstract_id": "25582984", "label": "results", "text": "Self-reported perfect use did not vary between obese -LSB- body mass index ( BMI ) @kg/m ( @ ) -RSB- versus nonobese ( BMI < @kg/m ( @ ) ) participants in both groups or when stratified by age , education , or race/ethnicity in the CP group .", "sentence_id": 7}
+{"abstract_id": "25582984", "label": "conclusions", "text": "Self-reported compliance was significantly greater in the CP than COC group and did not vary by obesity status .", "sentence_id": 8}
+{"abstract_id": "25582984", "label": "conclusions", "text": "Discrepancies between self-reported and verified compliance question reliability of patient diaries .", "sentence_id": 9}
+{"abstract_id": "25582984", "label": "conclusions", "text": "This paper , based on an analysis of a phase @ trial , shows that compliance was significantly greater with a new weekly transdermal CP than with a once-daily COC in obese as well as nonobese participants .", "sentence_id": 10}
+{"abstract_id": "25582984", "label": "conclusions", "text": "Discrepancies between self-reported compliance and laboratory-verified compliance raise questions regarding the reliability of patient diaries .", "sentence_id": 11}
+{"abstract_id": "25355940", "label": "background", "text": "Pediatric respiratory infections caused by antibiotic-nonsusceptible Streptococcus pneumoniae ( ANSP ) continue to present an important challenge , even after introduction of @-valent pneumococcal conjugate vaccine ( PCV@ ) .", "sentence_id": 0}
+{"abstract_id": "25355940", "label": "background", "text": "This randomized double-blind trial assessed the potential additional impact of PCV@ over PCV@ on reducing ANSP carriage .", "sentence_id": 1}
+{"abstract_id": "25355940", "label": "methods", "text": "Healthy infants were randomly assigned to receive PCV@ ( n = @ ) or PCV@ ( n = @ ) at ages @ , @ , @ , or @ months .", "sentence_id": 2}
+{"abstract_id": "25355940", "label": "methods", "text": "Eight nasopharyngeal specimens were collected by swabbing between ages @ and @ months .", "sentence_id": 3}
+{"abstract_id": "25355940", "label": "methods", "text": "S. pneumoniae isolates were serotyped and tested for antimicrobial susceptibility by the disk-diffusion method and the Etest .", "sentence_id": 4}
+{"abstract_id": "25355940", "label": "methods", "text": "Nasopharyngeal acquisition and prevalence of ANSP during ages @-@ months were compared between the @ vaccine groups .", "sentence_id": 5}
+{"abstract_id": "25355940", "label": "results", "text": "In general , new acquisition of pneumococci nonsusceptible to penicillin , erythromycin , clindamycin , penicillin plus erythromycin , and multiple drugs ( @ antibiotics ) was significantly lower in the PCV@ group compared with the PCV@ group ; the main serotypes contributing to this significant decrease were serotype @F , present in PCV@ and PCV@ , and serotypes @A and @A , present in PCV@ only .", "sentence_id": 6}
+{"abstract_id": "25355940", "label": "conclusions", "text": "PCV@ has a significant added benefit over PCV@ in reducing carriage of ANSP .", "sentence_id": 7}
+{"abstract_id": "25355940", "label": "conclusions", "text": "Because carriage determines transmission , these results suggest that PCV@ will provide protection against ANSP disease that exceeds protection provided by PCV@ .", "sentence_id": 8}
+{"abstract_id": "24893602", "label": "background", "text": "Homeless adults are more likely to smoke tobacco and are less likely to successfully quit smoking than smokers in the general population , despite comparable numbers of cessation attempts and desire to quit .", "sentence_id": 0}
+{"abstract_id": "24893602", "label": "background", "text": "To date , studies that have examined smoking cessation in homeless samples have used traditional lab/clinic-based assessment methodologies .", "sentence_id": 1}
+{"abstract_id": "24893602", "label": "background", "text": "Real-time assessment of key variables may provide new insights into the process of quitting among homeless smokers .", "sentence_id": 2}
+{"abstract_id": "24893602", "label": "methods", "text": "The purpose of the current study was to identify predictors of a quit attempt using real-time assessment methodology during the @ days prior to a scheduled quit attempt among homeless adults seeking care at a shelter-based smoking cessation clinic .", "sentence_id": 3}
+{"abstract_id": "24893602", "label": "methods", "text": "Parameters for multiple variables ( i.e. , motivation for quitting , smoking expectancies , quit self-efficacy , smoking urges , negative affect , positive affect , restlessness , hostility , and stress ) were calculated and were used as predictors of biochemically verified quit date abstinence ( i.e. , @hr abstinent ) using logistic regression analyses .", "sentence_id": 4}
+{"abstract_id": "24893602", "label": "results", "text": "Participants ( n = @ ) were predominantly male ( @ % ) , non-White ( @ % ) , and smoked an average of @ cigarettes per day .", "sentence_id": 5}
+{"abstract_id": "24893602", "label": "results", "text": "A total of @,@ ecological momentary assessments ( @ % completion rate ) were collected at random times ( i.e. , up to @ assessments/day ) during the @ days prior to a scheduled quit attempt .", "sentence_id": 6}
+{"abstract_id": "24893602", "label": "results", "text": "Results indicated that declining ( negative slope ) negative affect , restlessness , and stress predicted quit date abstinence .", "sentence_id": 7}
+{"abstract_id": "24893602", "label": "results", "text": "Additionally , increasing positive coping expectancies across the prequit week predicted quit date abstinence .", "sentence_id": 8}
+{"abstract_id": "24893602", "label": "conclusions", "text": "Study findings highlight multiple variables that may be targeted during the precessation period to increase smoking cessation attempts in this difficult to treat population of smokers .", "sentence_id": 9}
+{"abstract_id": "25231884", "label": "objective", "text": "The goal of this research was to evaluate nutrition education targeting Latinas , a group at particular risk of obesity and diabetes , which predict to later life cardiovascular disease and dementia .", "sentence_id": 0}
+{"abstract_id": "25231884", "label": "methods", "text": "Culturally tailored , theory-based nutrition education was provided to Mexican origin Latinas aged @ to @ .", "sentence_id": 1}
+{"abstract_id": "25231884", "label": "methods", "text": "The randomized design compared participants in workshops incorporating the connection between dietary fat and brain health , participants in workshops focusing only on dietary fat and heart health , a waitlist control group , and a posttest only control group .", "sentence_id": 2}
+{"abstract_id": "25231884", "label": "results", "text": "Among those assigned to either intervention , there was statistically significant gain in health literacy , knowledge about dietary fat , and behaviors to reduce dietary fat compared with waitlist control .", "sentence_id": 3}
+{"abstract_id": "25231884", "label": "results", "text": "There was no difference in outcomes between those given the module about diet and brain health and those not provided that module .", "sentence_id": 4}
+{"abstract_id": "25231884", "label": "conclusions", "text": "A program to encourage dietary fat modification in Latinas proved feasible and modestly effective .", "sentence_id": 5}
+{"abstract_id": "24709780", "label": "background", "text": "Umbilical cord milking ( UCM ) improves blood pressure and urine output , and decreases the need for transfusions in comparison to immediate cord clamping ( ICC ) .", "sentence_id": 0}
+{"abstract_id": "24709780", "label": "background", "text": "The immediate effect of UCM in the first few minutes of life and the impact on neonatal resuscitation has not been described .", "sentence_id": 1}
+{"abstract_id": "24709780", "label": "methods", "text": "Women admitted to a tertiary care center and delivering before @ weeks gestation were randomized to receive UCM or ICC .", "sentence_id": 2}
+{"abstract_id": "24709780", "label": "methods", "text": "A blinded analysis of physiologic data collected on the newborns in the delivery room was performed using a data acquisition system .", "sentence_id": 3}
+{"abstract_id": "24709780", "label": "methods", "text": "Heart rate ( HR ) , SpO@ , mean airway pressure ( MAP ) , and FiO@ in the delivery room were compared between infants receiving UCM and infants with ICC .", "sentence_id": 4}
+{"abstract_id": "24709780", "label": "results", "text": "@ of @ neonates who were enrolled and randomized had data from analog tracings at birth .", "sentence_id": 5}
+{"abstract_id": "24709780", "label": "results", "text": "@ of these infants received UCM and @ had ICC .", "sentence_id": 6}
+{"abstract_id": "24709780", "label": "results", "text": "Infants receiving UCM had higher heart rates and higher SpO@ over the first @ minutes of life , were exposed to less FiO@ over the first @ minutes of life than infants with ICC .", "sentence_id": 7}
+{"abstract_id": "24709780", "label": "conclusions", "text": "UCM when compared to ICC had decreased need for support immediately following delivery , and in situations where resuscitation interventions were needed immediately , UCM has the advantage of being completed in a very short time to improve stability following delivery .", "sentence_id": 8}
+{"abstract_id": "24723041", "label": "objective", "text": "Dialectical Behavior Therapy has been initially designed and evaluated as an outpatient-treatment program for chronic suicidal female patients .", "sentence_id": 0}
+{"abstract_id": "24723041", "label": "objective", "text": "Within the last years , several adaptations of DBT for specific comorbidities , other settings or other disorders related to emotion dysregulation have been developed .", "sentence_id": 1}
+{"abstract_id": "24723041", "label": "objective", "text": "This report reviews conceptual aspects and the scientific evidence of initially designed Dialectical Behavior Therapy and the adaptations .", "sentence_id": 2}
+{"abstract_id": "24723041", "label": "methods", "text": "Systematic literature search and systematic review .", "sentence_id": 3}
+{"abstract_id": "24723041", "label": "results", "text": "Recently , two meta-analyses which are based on randomized controlled trials conclude robust and stabile effects of DBT Evidence from further RCTs and other studies show promise for the properties of many DBT adaptations .", "sentence_id": 4}
+{"abstract_id": "24723041", "label": "conclusions", "text": "The current review of the literature suggests a good effectiveness of DBT , especially on complex disorders with deficits in the field of emotion regulation .", "sentence_id": 5}
+{"abstract_id": "25374246", "label": "background", "text": "Breast cancer ( BC ) is the most common cancer among females in Turkey .", "sentence_id": 0}
+{"abstract_id": "25374246", "label": "background", "text": "Predictors affecting the breast self-examination ( BSE ) performance vary in developing countries .", "sentence_id": 1}
+{"abstract_id": "25374246", "label": "objective", "text": "To determine the frequency of BSE performance and predictors of self-reported BSEs among women in the capital city of Turkey .", "sentence_id": 2}
+{"abstract_id": "25374246", "label": "methods", "text": "This cross-sectional study was conducted on @ Turkish women using a self - administered questionnaire covering socio-demographic variables and BSE-related features .", "sentence_id": 3}
+{"abstract_id": "25374246", "label": "results", "text": "Of the participants , @ % ( N = @ ) reported practicing BSE , whereas @ % ( N = @ ) were implementing BSE regularly on a monthly basis , and only @ % ( N = @ ) were performing BSE regularly within a week after each menstrual cycle .", "sentence_id": 4}
+{"abstract_id": "25374246", "label": "results", "text": "Multivariate logistic regression modeling revealed that BSE performance was more likely in younger age groups -LSB- @-@ years -RSB- ( p = @ , OR = @ ) and -LSB- @-@ years -RSB- ( p = @ , OR = @ ) , women having a family history of breast disease ( p = @ , OR = @ ) , and housewives ( p = @ , OR = @ ) .", "sentence_id": 5}
+{"abstract_id": "25374246", "label": "conclusions", "text": "Although it appears that the rates of BSE performers are high , the number of women conducting appropriate BSE on a regular time interval basis is lower than expected .", "sentence_id": 6}
+{"abstract_id": "25374246", "label": "conclusions", "text": "Younger age groups , family history of breast diseases and not being employed were identified as significant predictors of practicing BSE appropriately .", "sentence_id": 7}
+{"abstract_id": "25374246", "label": "conclusions", "text": "Older age and employment were risk factors for not performing BSE in this sample .", "sentence_id": 8}
+{"abstract_id": "24286801", "label": "objective", "text": "To analyze the results of the use of intra-articular cultured autologous bone marrow-derived mesenchymal stem cell ( MSC ) injections in conjunction with microfracture and medial opening-wedge high tibial osteotomy ( HTO ) .", "sentence_id": 0}
+{"abstract_id": "24286801", "label": "methods", "text": "Fifty-six knees in @ patients with unicompartmental osteoarthritic knees and genu varum were randomly allocated to the cell-recipient group ( n = @ ) or control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24286801", "label": "methods", "text": "Patients who had a joint line congruity angle of more than @ , malalignment of the knee from femoral causes , a fixed flexion deformity , or age older than @ years were excluded .", "sentence_id": 2}
+{"abstract_id": "24286801", "label": "methods", "text": "All patients underwent HTO and microfracture .", "sentence_id": 3}
+{"abstract_id": "24286801", "label": "methods", "text": "The cell-recipient group received intra-articular injection of cultured MSCs with hyaluronic acid @ weeks after surgery , whereas the control group only received hyaluronic acid .", "sentence_id": 4}
+{"abstract_id": "24286801", "label": "methods", "text": "The primary outcome measure was the International Knee Documentation Committee ( IKDC ) score at intervals of @ months , @ year , and @ years postoperatively .", "sentence_id": 5}
+{"abstract_id": "24286801", "label": "methods", "text": "Secondary outcome measures were Tegner and Lysholm clinical scores and @-year postoperative Magnetic Resonance Observation of Cartilage Repair Tissue ( MOCART ) scores .", "sentence_id": 6}
+{"abstract_id": "24286801", "label": "results", "text": "The median age of the patients was @ years , with a mean body mass index of @ .", "sentence_id": 7}
+{"abstract_id": "24286801", "label": "results", "text": "Both treatment arms achieved improvements in Tegner , Lysholm , and IKDC scores .", "sentence_id": 8}
+{"abstract_id": "24286801", "label": "results", "text": "After adjustment for age , baseline scores , and time of evaluation , the cell-recipient group showed significantly better scores .", "sentence_id": 9}
+{"abstract_id": "24286801", "label": "results", "text": "The effect of treatment showed an added improvement of @ ( @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) for IKDC scores , @ ( @ % CI , @ to @ ; P = @ ) for Lysholm scores , and @ ( @ % CI , @ to @ ; P = @ ) for Tegner scores .", "sentence_id": 10}
+{"abstract_id": "24286801", "label": "results", "text": "Magnetic resonance imaging scans performed @ year after surgical intervention showed significantly better MOCART scores for the cell-recipient group .", "sentence_id": 11}
+{"abstract_id": "24286801", "label": "results", "text": "The age-adjusted mean difference in MOCART score was @ ( @ % CI , @ to @ ; P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24286801", "label": "conclusions", "text": "Intra-articular injection of cultured MSCs is effective in improving both short-term clinical and MOCART outcomes in patients undergoing HTO and microfracture for varus knees with cartilage defects .", "sentence_id": 13}
+{"abstract_id": "24286801", "label": "methods", "text": "Level II , randomized controlled trial .", "sentence_id": 14}
+{"abstract_id": "25187119", "label": "conclusions", "text": "This prospective study showed that the incidence of acute anterior uveitis , confirmed by ophthalmic examination , in patients receiving intravenous zoledronate infusions as part of a randomized controlled trial for fracture prevention is @ % .", "sentence_id": 0}
+{"abstract_id": "25187119", "label": "background", "text": "We prospectively investigated the incidence of ocular side effects after a single intravenous zoledronate infusion .", "sentence_id": 1}
+{"abstract_id": "25187119", "label": "methods", "text": "In a secondary analysis of a double-blind , placebo-controlled trial in which early post-menopausal women ( N = @ ) with normal bone density or osteopenia were randomized to infusion of zoledronate @ mg ( N = @ ) or placebo ( N = @ ) , we analyzed significant adverse ocular events occurring within @ months .", "sentence_id": 2}
+{"abstract_id": "25187119", "label": "results", "text": "Fourteen participants reported ocular symptoms after the infusion .", "sentence_id": 3}
+{"abstract_id": "25187119", "label": "results", "text": "All were examined by an ophthalmologist and eight were diagnosed with acute anterior uveitis ( AAU ) and one with sectoral episcleritis .", "sentence_id": 4}
+{"abstract_id": "25187119", "label": "results", "text": "The incidence of AAU and episcleritis was @ % ( @ % CI @-@ @ ) and @ % ( @ % CI @-@ @ ) , respectively , in the zoledronate group and @ % for both conditions in the placebo group ( @ % CI @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25187119", "label": "results", "text": "The mean time from infusion to symptom onset for AAU was @ days ( range @-@ ) .", "sentence_id": 6}
+{"abstract_id": "25187119", "label": "results", "text": "Three cases were bilateral .", "sentence_id": 7}
+{"abstract_id": "25187119", "label": "results", "text": "AAU was mild-moderate in seven participants and severe in one .", "sentence_id": 8}
+{"abstract_id": "25187119", "label": "results", "text": "All affected eyes were treated with topical cyclopentolate @ % ( to break , or minimize , posterior synechiae ) , and intensive , potent , topical corticosteroids with a tapering regime based on treatment response .", "sentence_id": 9}
+{"abstract_id": "25187119", "label": "results", "text": "The mean duration of topical corticosteroid was @ days ( range @-@ ) .", "sentence_id": 10}
+{"abstract_id": "25187119", "label": "results", "text": "The mean , best corrected visual acuity was @/@ ( range @/@-@ / @ ) at presentation , which remained unchanged after AAU resolution .", "sentence_id": 11}
+{"abstract_id": "25187119", "label": "results", "text": "None of the participants lost vision , and no long-term sequelae were reported at last follow-up ( range @-@ months post-infusion ) .", "sentence_id": 12}
+{"abstract_id": "25187119", "label": "conclusions", "text": "Prescribers should inform patients about the possibility of ocular side effects with zoledronate infusions and refer promptly to an ophthalmologist if symptoms develop .", "sentence_id": 13}
+{"abstract_id": "25301881", "label": "objective", "text": "To evaluate the outcomes of standard automated perimetry ( SAP ) in patients with obstructive sleep apnea ( OSA ) .", "sentence_id": 0}
+{"abstract_id": "25301881", "label": "methods", "text": "Eighty OSA patients and @ age-matched controls were consecutively and prospectively enrolled .", "sentence_id": 1}
+{"abstract_id": "25301881", "label": "methods", "text": "One eye per subject was randomly selected .", "sentence_id": 2}
+{"abstract_id": "25301881", "label": "methods", "text": "All participants underwent at least one reliable SAP ( @-@ SITA Standard algorithm ) .", "sentence_id": 3}
+{"abstract_id": "25301881", "label": "methods", "text": "The peripapillary retinal nerve fiber layer thickness ( RNFL ) was measured with spectral-domain optical coherence tomography ( OCT ) .", "sentence_id": 4}
+{"abstract_id": "25301881", "label": "methods", "text": "Patients with OSA were classified into three groups according to the apnea/hypopnea index : mild , moderate , or severe OSA .", "sentence_id": 5}
+{"abstract_id": "25301881", "label": "methods", "text": "Parameters of SAP and OCT were compared between healthy controls and OSA patients .", "sentence_id": 6}
+{"abstract_id": "25301881", "label": "methods", "text": "Correlation of apnea/hypopnea index with OCT and SAP measurements were calculated .", "sentence_id": 7}
+{"abstract_id": "25301881", "label": "results", "text": "Mean age , best-corrected visual acuity , and central corneal thickness were similar between groups .", "sentence_id": 8}
+{"abstract_id": "25301881", "label": "results", "text": "Intraocular pressure , however , was lower in the OSA group .", "sentence_id": 9}
+{"abstract_id": "25301881", "label": "results", "text": "Mean deviation of SAP was -@ @ dB in the control group and -@ @ dB in the OSA group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25301881", "label": "results", "text": "Thickness of RNFL measured with OCT did not differ significantly between groups .", "sentence_id": 11}
+{"abstract_id": "25301881", "label": "results", "text": "Patients with OSA showed reduced sensitivity at most points tested by white-on-white perimetry compared with healthy individuals .", "sentence_id": 12}
+{"abstract_id": "25301881", "label": "results", "text": "The threshold values were more depressed in the peripheral visual field .", "sentence_id": 13}
+{"abstract_id": "25301881", "label": "results", "text": "The apnea/hypopnea index was related to the SAP indices : Pearson correlations were -@ with mean deviation , @ with pattern standard deviation , and -@ with the visual field index ( P < @ ) .", "sentence_id": 14}
+{"abstract_id": "25301881", "label": "conclusions", "text": "Patients with OSA exhibited reduced retinal sensitivity measured with SAP compared with healthy controls .", "sentence_id": 15}
+{"abstract_id": "25337750", "label": "background", "text": "A fluoropyrimidine plus irinotecan or oxaliplatin , combined with bevacizumab ( a monoclonal antibody against vascular endothelial growth factor ) , is standard first-line treatment for metastatic colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "25337750", "label": "background", "text": "Before the introduction of bevacizumab , chemotherapy with fluorouracil , leucovorin , oxaliplatin , and irinotecan ( FOLFOXIRI ) showed superior efficacy as compared with fluorouracil , leucovorin , and irinotecan ( FOLFIRI ) .", "sentence_id": 1}
+{"abstract_id": "25337750", "label": "background", "text": "In a phase @ study , FOLFOXIRI plus bevacizumab showed promising activity and an acceptable rate of adverse effects .", "sentence_id": 2}
+{"abstract_id": "25337750", "label": "methods", "text": "We randomly assigned @ patients with untreated metastatic colorectal cancer to receive either FOLFIRI plus bevacizumab ( control group ) or FOLFOXIRI plus bevacizumab ( experimental group ) .", "sentence_id": 3}
+{"abstract_id": "25337750", "label": "methods", "text": "Up to @ cycles of treatment were administered , followed by fluorouracil plus bevacizumab until disease progression .", "sentence_id": 4}
+{"abstract_id": "25337750", "label": "methods", "text": "The primary end point was progression-free survival .", "sentence_id": 5}
+{"abstract_id": "25337750", "label": "results", "text": "The median progression-free survival was @ months in the experimental group , as compared with @ months in the control group ( hazard ratio for progression , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25337750", "label": "results", "text": "The objective response rate was @ % in the experimental group and @ % in the control group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25337750", "label": "results", "text": "Overall survival was longer , but not significantly so , in the experimental group ( @ vs. @ months ; hazard ratio for death , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25337750", "label": "results", "text": "The incidences of grade @ or @ neurotoxicity , stomatitis , diarrhea , and neutropenia were significantly higher in the experimental group .", "sentence_id": 9}
+{"abstract_id": "25337750", "label": "conclusions", "text": "FOLFOXIRI plus bevacizumab , as compared with FOLFIRI plus bevacizumab , improved the outcome in patients with metastatic colorectal cancer and increased the incidence of some adverse events .", "sentence_id": 10}
+{"abstract_id": "25337750", "label": "conclusions", "text": "( Funded by the Gruppo Oncologico Nord Ovest and others ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24613160", "label": "objective", "text": "To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same heparinization protocol .", "sentence_id": 0}
+{"abstract_id": "24613160", "label": "methods", "text": "In a randomized , controlled , multicenter trial , @ patients more than @ years of age received either on-pump or off-pump coronary artery bypass surgery .", "sentence_id": 1}
+{"abstract_id": "24613160", "label": "methods", "text": "Heparin was given to achieve an activated clotting time of @ seconds before arteriotomy in both groups .", "sentence_id": 2}
+{"abstract_id": "24613160", "label": "methods", "text": "After the procedure , protamine sulfate was given to revert the activated clotting time to less than @ seconds .", "sentence_id": 3}
+{"abstract_id": "24613160", "label": "methods", "text": "Coronary angiography was performed @ months after the operation and graft patency was assessed by independent blinded observers .", "sentence_id": 4}
+{"abstract_id": "24613160", "label": "results", "text": "A total of @ patients underwent angiography .", "sentence_id": 5}
+{"abstract_id": "24613160", "label": "results", "text": "In the off-pump group , @ ( @ % ) of @ grafts were open , @ ( @ % ) were stenotic , and @ ( @ % ) were occluded .", "sentence_id": 6}
+{"abstract_id": "24613160", "label": "results", "text": "In the on-pump group , @ ( @ % ) of @ grafts were open , @ ( @ % ) were stenotic , and @ ( @ % ) were occluded .", "sentence_id": 7}
+{"abstract_id": "24613160", "label": "results", "text": "The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24613160", "label": "results", "text": "The proportion of open left internal thoracic artery grafts was @ % in both groups .", "sentence_id": 9}
+{"abstract_id": "24613160", "label": "results", "text": "Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis .", "sentence_id": 10}
+{"abstract_id": "24613160", "label": "conclusions", "text": "Despite comparable heparinization , graft patency after off-pump surgery was inferior to that after on-pump surgery .", "sentence_id": 11}
+{"abstract_id": "26121788", "label": "background", "text": "The recommended intake of clear liquids until @ hours before surgery is reportedly safe and effective .", "sentence_id": 0}
+{"abstract_id": "26121788", "label": "background", "text": "We investigated whether oral rehydration therapy before surgery had improved satisfaction , stress response , and hemodynamics in patients during perioperative period .", "sentence_id": 1}
+{"abstract_id": "26121788", "label": "methods", "text": "Patients scheduled to undergo laparoscopic colectomy were enrolled and randomly divided into @ groups .", "sentence_id": 2}
+{"abstract_id": "26121788", "label": "methods", "text": "The oral rehydration therapy ( ORT ) group ( @ cases ) was allowed to drink clear liquids until @ hours before anesthesia induction and the control group ( @ cases ) fasted from @ : @ the night before surgery .", "sentence_id": 3}
+{"abstract_id": "26121788", "label": "methods", "text": "All patients entered the operating room at @ : @ .", "sentence_id": 4}
+{"abstract_id": "26121788", "label": "methods", "text": "Patient satisfaction was examined after admission to the operating room .", "sentence_id": 5}
+{"abstract_id": "26121788", "label": "methods", "text": "The volume and pH of gastric fluid were measured after anesthetic induction .", "sentence_id": 6}
+{"abstract_id": "26121788", "label": "methods", "text": "The serum concentrations of cortisol and catecholamine were measured as stress response indicators after anesthetic induction and at the completion of surgery .", "sentence_id": 7}
+{"abstract_id": "26121788", "label": "methods", "text": "Intraoperative hemodynamics was also recorded .", "sentence_id": 8}
+{"abstract_id": "26121788", "label": "results", "text": "There were no differences in patient satisfaction , stress response , and hemodynamics between the @ groups .", "sentence_id": 9}
+{"abstract_id": "26121788", "label": "results", "text": "Intraoperative urine volume was significantly larger in the ORT group .", "sentence_id": 10}
+{"abstract_id": "26121788", "label": "results", "text": "Vomiting and aspiration were not observed in any patient", "sentence_id": 11}
+{"abstract_id": "26121788", "label": "conclusions", "text": "Oral rehydration therapy until @ hours before surgery seemed safe but did not improve satisfaction , stress response , and hemodynamics in perioperative patients .", "sentence_id": 12}
+{"abstract_id": "25278093", "label": "background", "text": "Residual proteinuria during renin-angiotensin-aldosterone system ( RAAS ) blockade is a major renal and cardiovascular risk factor in chronic kidney disease .", "sentence_id": 0}
+{"abstract_id": "25278093", "label": "background", "text": "Dietary sodium restriction potentiates the antiproteinuric effect of RAAS blockade , but residual proteinuria remains in many patients .", "sentence_id": 1}
+{"abstract_id": "25278093", "label": "background", "text": "Previous studies linked high fibroblast growth factor @ ( FGF-@ ) levels with volume overload ; others linked higher serum phosphate levels with impaired RAAS-blockade efficacy .", "sentence_id": 2}
+{"abstract_id": "25278093", "label": "background", "text": "We hypothesized that FGF-@ reduces the capacity of dietary sodium restriction to potentiate RAAS blockade , impairing the antiproteinuric effect .", "sentence_id": 3}
+{"abstract_id": "25278093", "label": "methods", "text": "Post hoc analysis of cohort data from a randomized crossover trial with two @-week study periods comparing proteinuria after a regular-sodium diet with proteinuria after a low-sodium diet , both during background angiotensin-converting enzyme inhibition .", "sentence_id": 4}
+{"abstract_id": "25278093", "label": "methods", "text": "@ nondiabetic patients with CKD with residual proteinuria ( median protein excretion , @ -LSB- IQR , @-@ @ -RSB- g/d ; mean age , @ -LSB- SD -RSB- years ; creatinine clearance , @ -LSB- IQR , @-@ -RSB- mL/min ) .", "sentence_id": 5}
+{"abstract_id": "25278093", "label": "methods", "text": "Plasma carboxy-terminal FGF-@ levels .", "sentence_id": 6}
+{"abstract_id": "25278093", "label": "results", "text": "Difference in residual proteinuria at the end of the regular-sodium versus low-sodium study period .", "sentence_id": 7}
+{"abstract_id": "25278093", "label": "results", "text": "Residual proteinuria during the low-sodium diet period adjusted for proteinuria during the regular-sodium diet period .", "sentence_id": 8}
+{"abstract_id": "25278093", "label": "results", "text": "Higher baseline FGF-@ level was associated with reduced antiproteinuric response to dietary sodium restriction ( standardized = -@ ; P = @ ; model R ( @ ) = @ ) .", "sentence_id": 9}
+{"abstract_id": "25278093", "label": "results", "text": "For every @-RU/mL increase in FGF-@ level , the antiproteinuric response to dietary sodium restriction was reduced by @ % .", "sentence_id": 10}
+{"abstract_id": "25278093", "label": "results", "text": "Higher baseline FGF-@ level was a determinant of more residual proteinuria during the low-sodium diet ( standardized = @ ; P = @ ) in linear regression analysis adjusted for baseline proteinuria ( model R ( @ ) = @ ) .", "sentence_id": 11}
+{"abstract_id": "25278093", "label": "results", "text": "There was no interaction with creatinine clearance ( P interaction = @ ) .", "sentence_id": 12}
+{"abstract_id": "25278093", "label": "results", "text": "Baseline FGF-@ level did not predict changes in systolic or diastolic blood pressure upon intensified antiproteinuric treatment .", "sentence_id": 13}
+{"abstract_id": "25278093", "label": "conclusions", "text": "Observational study , limited sample size .", "sentence_id": 14}
+{"abstract_id": "25278093", "label": "conclusions", "text": "FGF-@ levels are associated independently with impaired antiproteinuric response to sodium restriction in addition to RAAS blockade .", "sentence_id": 15}
+{"abstract_id": "25278093", "label": "conclusions", "text": "Future studies should address whether FGF-@-lowering strategies may further optimize proteinuria reduction by RAAS blockade combined with dietary sodium restriction .", "sentence_id": 16}
+{"abstract_id": "26284719", "label": "objective", "text": "Low-molecular-weight heparin is recommended over warfarin for the treatment of acute venous thromboembolism ( VTE ) in patients with active cancer largely based on results of a single , large trial .", "sentence_id": 0}
+{"abstract_id": "26284719", "label": "objective", "text": "To study the efficacy and safety of tinzaparin vs warfarin for treatment of acute , symptomatic VTE in patients with active cancer .", "sentence_id": 1}
+{"abstract_id": "26284719", "label": "methods", "text": "A randomized , open-label study with blinded central adjudication of study outcomes enrolled patients in @ centers in Asia , Africa , Europe , and North , Central , and South America between August @ and November @ .", "sentence_id": 2}
+{"abstract_id": "26284719", "label": "methods", "text": "Adult patients with active cancer ( defined as histologic diagnosis of cancer and receiving anticancer therapy or diagnosed with , or received such therapy , within the previous @ months ) and objectively documented proximal deep vein thrombosis ( DVT ) or pulmonary embolism , with a life expectancy greater than @ months and without contraindications for anticoagulation , were followed up for @ days and for @ days after the last study medication dose for collection of safety data .", "sentence_id": 3}
+{"abstract_id": "26284719", "label": "methods", "text": "Tinzaparin ( @ IU/kg ) once daily for @ months vs conventional therapy with tinzaparin ( @ IU/kg ) once daily for @ to @ days followed by warfarin at a dose adjusted to maintain the international normalized ratio within the therapeutic range ( @-@ @ ) for @ months .", "sentence_id": 4}
+{"abstract_id": "26284719", "label": "methods", "text": "Primary efficacy outcome was a composite of centrally adjudicated recurrent DVT , fatal or nonfatal pulmonary embolism , and incidental VTE .", "sentence_id": 5}
+{"abstract_id": "26284719", "label": "methods", "text": "Safety outcomes included major bleeding , clinically relevant nonmajor bleeding , and overall mortality .", "sentence_id": 6}
+{"abstract_id": "26284719", "label": "results", "text": "Nine hundred patients were randomized and included in intention-to-treat efficacy and safety analyses .", "sentence_id": 7}
+{"abstract_id": "26284719", "label": "results", "text": "Recurrent VTE occurred in @ of @ patients treated with tinzaparin and @ of @ patients treated with warfarin ( @-month cumulative incidence , @ % for tinzaparin vs @ % for warfarin ; hazard ratio -LSB- HR -RSB- , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26284719", "label": "results", "text": "There were no differences in major bleeding ( @ patients for tinzaparin vs @ patients for warfarin ; HR , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) or overall mortality ( @ patients for tinzaparin vs @ patients for warfarin ; HR , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26284719", "label": "results", "text": "A significant reduction in clinically relevant nonmajor bleeding was observed with tinzaparin ( @ of @ patients for tinzaparin vs @ of @ patients for warfarin ; HR , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26284719", "label": "conclusions", "text": "Among patients with active cancer and acute symptomatic VTE , the use of full-dose tinzaparin ( @ IU/kg ) daily compared with warfarin for @ months did not significantly reduce the composite measure of recurrent VTE and was not associated with reductions in overall mortality or major bleeding , but was associated with a lower rate of clinically relevant nonmajor bleeding .", "sentence_id": 11}
+{"abstract_id": "26284719", "label": "conclusions", "text": "Further studies are needed to assess whether the efficacy outcomes would be different in patients at higher risk of recurrent VTE .", "sentence_id": 12}
+{"abstract_id": "24567515", "label": "background", "text": "The role of body mass index ( BMI ) in survival outcomes is controversial among lymphoma patients .", "sentence_id": 0}
+{"abstract_id": "24567515", "label": "background", "text": "We evaluated the association between BMI at study entry and failure-free survival ( FFS ) and overall survival ( OS ) in three phase III clinical trials , among patients with diffuse large B-cell lymphoma ( DLBCL ) , follicular lymphoma ( FL ) and Hodgkin 's lymphoma ( HL ) .", "sentence_id": 1}
+{"abstract_id": "24567515", "label": "methods", "text": "A total of @ , @ and @ patients with DLBCL , HL and FL were included in the analysis .", "sentence_id": 2}
+{"abstract_id": "24567515", "label": "methods", "text": "Baseline patient and clinical characteristics , treatment received and clinical outcomes were compared across BMI categories .", "sentence_id": 3}
+{"abstract_id": "24567515", "label": "results", "text": "Among patients with DLBCL , HL and FL , the median age was @ , @ and @ ; @ % , @ % and @ % were obese and @ % , @ % and @ % were overweight , respectively .", "sentence_id": 4}
+{"abstract_id": "24567515", "label": "results", "text": "Age was significantly different among BMI groups in all three studies .", "sentence_id": 5}
+{"abstract_id": "24567515", "label": "results", "text": "Higher BMI groups tended to have more favorable prognosis factors at study entry among DLBCL and HL patients .", "sentence_id": 6}
+{"abstract_id": "24567515", "label": "results", "text": "BMI was not associated with clinical outcome with P-values of @ , @ and @ for FFS , and @ , @ and @ for OS , for patients with DLBCL , HL and FL , respectively .", "sentence_id": 7}
+{"abstract_id": "24567515", "label": "results", "text": "The association remains non-significant after adjusting for other clinical factors in the Cox model .", "sentence_id": 8}
+{"abstract_id": "24567515", "label": "results", "text": "A subset analysis of males with DLBCL treated on R-CHOP revealed no differences in FFS ( P = @ ) or OS ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24567515", "label": "conclusions", "text": "BMI was not significantly associated with clinical outcomes among patients with DLBCL , HD or FL , in three prospective phase III clinical trials .", "sentence_id": 10}
+{"abstract_id": "24567515", "label": "conclusions", "text": "The findings contradict some previous reports of similar investigations .", "sentence_id": 11}
+{"abstract_id": "24567515", "label": "conclusions", "text": "Further work is required to understand the observed discrepancies .", "sentence_id": 12}
+{"abstract_id": "24853275", "label": "objective", "text": "Although transcatheter arterial chemoembolization ( TACE ) is the most common treatment option in patients with hepatocellular carcinoma ( HCC ) , its clinical benefits remain still controversial .", "sentence_id": 0}
+{"abstract_id": "24853275", "label": "objective", "text": "Since TACE induces hypoxic necrosis in tumors , hypoxia-inducible factor @ ( HIF-@ ) could critically affect biology in residual tumors after TACE treatment and subsequent prognosis .", "sentence_id": 1}
+{"abstract_id": "24853275", "label": "objective", "text": "However , HIF-@ and its prognostic relevance in TACE have rarely been examined in human specimens .", "sentence_id": 2}
+{"abstract_id": "24853275", "label": "objective", "text": "In the current study , we investigated the prognosis and expression of genes regulated by HIF-@ in HCC patients receiving preoperative TACE for the first time .", "sentence_id": 3}
+{"abstract_id": "24853275", "label": "methods", "text": "In total , @ patients with HCC ( @ patients undergoing preoperative TACE ) were retrospectively studied .", "sentence_id": 4}
+{"abstract_id": "24853275", "label": "methods", "text": "The prognostic significance of TACE was analyzed using Kaplan-Meier and Cox regression models .", "sentence_id": 5}
+{"abstract_id": "24853275", "label": "methods", "text": "Protein levels of HIF-@ and mRNA levels of HIF-@-associated genes were examined using immunohistochemistry ( IHC ) and real-time RT-PCR , respectively .", "sentence_id": 6}
+{"abstract_id": "24853275", "label": "results", "text": "Preoperative TACE was significantly associated with increased @-year recurrence rate ( @ vs. @ % , P = @ ) and shorter disease-free survival ( DFS ) time ( @ vs. @ months , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24853275", "label": "results", "text": "TACE was an independent prognostic factor for recurrence ( P = @ ) and poor DFS ( P = @ ) in a multivariate analysis .", "sentence_id": 8}
+{"abstract_id": "24853275", "label": "results", "text": "Immunohistochemical staining revealed in vivo activation of HIF-@ in human specimens treated with TACE .", "sentence_id": 9}
+{"abstract_id": "24853275", "label": "results", "text": "Notably , protein levels of HIF-@ were significantly increased in TACE tissues demonstrated by IHC .", "sentence_id": 10}
+{"abstract_id": "24853275", "label": "results", "text": "Transcriptional targets of HIF-@ showed mRNA expression patterns consistent with activation of HIF-@ in TACE tissues .", "sentence_id": 11}
+{"abstract_id": "24853275", "label": "conclusions", "text": "Our findings collectively demonstrate that preoperative TACE confers poor prognosis in HCC patients through activation of HIF-@ .", "sentence_id": 12}
+{"abstract_id": "25190728", "label": "background", "text": "There are conflicting reports on the impact of soy on breast carcinogenesis .", "sentence_id": 0}
+{"abstract_id": "25190728", "label": "background", "text": "This study examines the effects of soy supplementation on breast cancer-related genes and pathways .", "sentence_id": 1}
+{"abstract_id": "25190728", "label": "methods", "text": "Women ( n = @ ) with early-stage breast cancer were randomly assigned to soy protein supplementation ( n = @ ) or placebo ( n = @ ) for @ to @ days , from diagnosis until surgery .", "sentence_id": 2}
+{"abstract_id": "25190728", "label": "methods", "text": "Adherence was determined by plasma isoflavones : genistein and daidzein .", "sentence_id": 3}
+{"abstract_id": "25190728", "label": "methods", "text": "Gene expression changes were evaluated by NanoString in pre - and posttreatment tumor tissue .", "sentence_id": 4}
+{"abstract_id": "25190728", "label": "methods", "text": "Genome-wide expression analysis was performed on posttreatment tissue .", "sentence_id": 5}
+{"abstract_id": "25190728", "label": "methods", "text": "Proliferation ( Ki@ ) and apoptosis ( Cas@ ) were assessed by immunohistochemistry .", "sentence_id": 6}
+{"abstract_id": "25190728", "label": "results", "text": "Plasma isoflavones rose in the soy group ( two-sided Wilcoxon rank-sum test , P < @ ) and did not change in the placebo group .", "sentence_id": 7}
+{"abstract_id": "25190728", "label": "results", "text": "In paired analysis of pre - and posttreatment samples , @ genes ( out of @ ) showed altered expression ( two-sided Student 's t-test , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25190728", "label": "results", "text": "Several genes including FANCC and UGT@A@ revealed different magnitude and direction of expression changes between the two groups ( two-sided Student 's t-test , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25190728", "label": "results", "text": "A high-genistein signature consisting of @ differentially expressed genes was identified from microarray analysis of tumors .", "sentence_id": 10}
+{"abstract_id": "25190728", "label": "results", "text": "This signature was characterized by overexpression ( > @-fold ) of cell cycle transcripts , including those that promote cell proliferation , such as FGFR@ , E@F@ , BUB@ , CCNB@ , MYBL@ , CDK@ , and CDC@ ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25190728", "label": "results", "text": "Soy intake did not result in statistically significant changes in Ki@ or Cas@ .", "sentence_id": 12}
+{"abstract_id": "25190728", "label": "conclusions", "text": "Gene expression associated with soy intake and high plasma genistein defines a signature characterized by overexpression of FGFR@ and genes that drive cell cycle and proliferation pathways .", "sentence_id": 13}
+{"abstract_id": "25190728", "label": "conclusions", "text": "These findings raise the concerns that in a subset of women soy could adversely affect gene expression in breast cancer .", "sentence_id": 14}
+{"abstract_id": "24290594", "label": "objective", "text": "The aim of this study was to examine the effect of yeast hydrolysate on the abdominal fat in obese humans .", "sentence_id": 0}
+{"abstract_id": "24290594", "label": "methods", "text": "We observed the effects of yeast hydrolysate that had a molecular weight below @ kDa on the anti-abdominal fat accumulation in obese men and women ages @ to @ y for @ wk .", "sentence_id": 1}
+{"abstract_id": "24290594", "label": "methods", "text": "The abdominal fat mass was assessed by computed tomographic scans .", "sentence_id": 2}
+{"abstract_id": "24290594", "label": "results", "text": "By the sixth week , the reductions in energy intake in the yeast group ( yeast hydrolysate @ g/d ) were significantly greater than those in the control group ( placebo @ g/d ) ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24290594", "label": "results", "text": "The body weight and body mass index ( BMI ) were significantly reduced by week @ compared with baseline in the yeast group , and these differences were significantly greater than those in the control group : body weight @ kg versus -@ k g ( P < @ ) , BMI @ kg/m ( @ ) versus -@ kg/m ( @ ) ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24290594", "label": "results", "text": "Despite the increased loss of body weight in the yeast group , lean body mass did not significantly differ between the two groups .", "sentence_id": 5}
+{"abstract_id": "24290594", "label": "results", "text": "Body fat mass in the control group did not significantly change between baseline and week @ .", "sentence_id": 6}
+{"abstract_id": "24290594", "label": "results", "text": "However , the yeast group lost a significant amount of body fat mass after @ wk of treatment ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24290594", "label": "results", "text": "The differences in abdominal fat thickness and abdominal circumference between the two groups were significant after @ wk of treatment ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24290594", "label": "results", "text": "The total abdominal fat area in the yeast group was significantly lower than in the control group after @ wk of treatment ( -@ cm ( @ ) versus -@ cm ( @ ) ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24290594", "label": "conclusions", "text": "Yeast hydrolysate can reduce body weight and the accumulation of abdominal fat without an adverse effect on lean body mass in obese adults , regardless of sex , via the reduction of energy intake .", "sentence_id": 10}
+{"abstract_id": "24261644", "label": "background", "text": "Delirium is a frequent disorder in intensive care unit ( ICU ) patients with serious consequences .", "sentence_id": 0}
+{"abstract_id": "24261644", "label": "background", "text": "Therefore , preventive treatment for delirium may be beneficial .", "sentence_id": 1}
+{"abstract_id": "24261644", "label": "background", "text": "Worldwide , haloperidol is the first choice for pharmacological treatment of delirious patients .", "sentence_id": 2}
+{"abstract_id": "24261644", "label": "background", "text": "In daily clinical practice , a lower dose is sometimes used as prophylaxis .", "sentence_id": 3}
+{"abstract_id": "24261644", "label": "background", "text": "Some studies have shown the beneficial effects of prophylactic haloperidol on delirium incidence as well as on mortality , but evidence for effectiveness in ICU patients is limited .", "sentence_id": 4}
+{"abstract_id": "24261644", "label": "background", "text": "The primary objective of our study is to determine the effect of haloperidol prophylaxis on @-day survival .", "sentence_id": 5}
+{"abstract_id": "24261644", "label": "background", "text": "Secondary objectives include the incidence of delirium and delirium-related outcome and the side effects of haloperidol prophylaxis .", "sentence_id": 6}
+{"abstract_id": "24261644", "label": "methods", "text": "This will be a multicenter three-armed randomized , double-blind , placebo-controlled , prophylactic intervention study in critically ill patients .", "sentence_id": 7}
+{"abstract_id": "24261644", "label": "methods", "text": "We will include consecutive non-neurological ICU patients , aged @ years with an expected ICU length of stay > @ day .", "sentence_id": 8}
+{"abstract_id": "24261644", "label": "methods", "text": "To be able to demonstrate a @ % increase in @-day survival time with a power of @ % and alpha of @ in both intervention groups , a total of @,@ patients will be randomized ; @ in each group .", "sentence_id": 9}
+{"abstract_id": "24261644", "label": "methods", "text": "The anticipated mortality rate in the placebo group is @ % .", "sentence_id": 10}
+{"abstract_id": "24261644", "label": "methods", "text": "The intervention groups will receive prophylactic treatment with intravenous haloperidol @ mg/q@h or @ mg/q@h , and patients in the control group will receive placebo ( sodium chloride @ % ) , both for a maximum period of @-days .", "sentence_id": 11}
+{"abstract_id": "24261644", "label": "methods", "text": "In patients who develop delirium , study medication will be stopped and patients will subsequently receive open label treatment with a higher ( therapeutic ) dose of haloperidol .", "sentence_id": 12}
+{"abstract_id": "24261644", "label": "methods", "text": "We will use descriptive summary statistics as well as Cox proportional hazard regression analyses , adjusted for covariates .", "sentence_id": 13}
+{"abstract_id": "24261644", "label": "conclusions", "text": "This will be the first large-scale multicenter randomized controlled prevention study with haloperidol in ICU patients with a high risk of delirium , adequately powered to demonstrate an effect on @-day survival .", "sentence_id": 14}
+{"abstract_id": "25373630", "label": "background", "text": "Intranasal ( IN ) insulin acutely improves verbal memory in mild cognitive impairment ( MCI ) / Alzheimer 's disease ( AD ) , but its therapeutic effects may be attenuated in apolipoprotein E@ ( ApoE@ ) carriers .", "sentence_id": 0}
+{"abstract_id": "25373630", "label": "background", "text": "Furthermore , rapid-acting ( RA ) insulins may have superior therapeutic effects compared with regular insulin types .", "sentence_id": 1}
+{"abstract_id": "25373630", "label": "objective", "text": "To measure the safety and efficacy of intranasally delivered RA glulisine in ApoE@ carriers with mild-moderate AD .", "sentence_id": 2}
+{"abstract_id": "25373630", "label": "methods", "text": "We performed a double-blinded , randomized , cross-over study of RA insulin glulisine in nine mild-moderate AD subjects to better understand the relationship between RA insulin , ApoE@ carrier status and memory performance .", "sentence_id": 3}
+{"abstract_id": "25373630", "label": "results", "text": "IN glulisine was well tolerated but failed to have an acute impact on cognition in ApoE@ carriers with AD .", "sentence_id": 4}
+{"abstract_id": "25373630", "label": "results", "text": "Serum insulin levels acutely dropped following treatment , but peripheral glucose levels remained unchanged .", "sentence_id": 5}
+{"abstract_id": "25373630", "label": "conclusions", "text": "Larger clinical trials of longer duration are necessary to better understand the relationships between RA insulin , ApoE@ carrier status and cognitive performance in AD .", "sentence_id": 6}
+{"abstract_id": "25344693", "label": "background", "text": "Health-promoting lifestyle choices of adolescents are closely related to current and subsequent health status .", "sentence_id": 0}
+{"abstract_id": "25344693", "label": "background", "text": "However , parsimonious yet reliable and valid screening tools are scarce .", "sentence_id": 1}
+{"abstract_id": "25344693", "label": "background", "text": "The original @-item adolescent health promotion ( AHP ) scale was developed by our research team and has been applied to measure adolescent health-promoting behaviors worldwide .", "sentence_id": 2}
+{"abstract_id": "25344693", "label": "background", "text": "The aim of our study was to examine the psychometric properties of a newly developed short-form version of the AHP ( AHP-SF ) including tests of its reliability and validity .", "sentence_id": 3}
+{"abstract_id": "25344693", "label": "methods", "text": "The study was conducted in nine middle and high schools in southern Taiwan .", "sentence_id": 4}
+{"abstract_id": "25344693", "label": "methods", "text": "Participants were @ adolescents randomly divided into two subgroups with equal size and homogeneity of baseline characteristics .", "sentence_id": 5}
+{"abstract_id": "25344693", "label": "methods", "text": "The first subsample ( calibration sample ) was used to modify and shorten the factorial model while the second subsample ( validation sample ) was utilized to validate the result obtained from the first one .", "sentence_id": 6}
+{"abstract_id": "25344693", "label": "methods", "text": "The psychometric testing of the AHP-SF included internal reliability of McDonald 's omega and Cronbach 's alpha , convergent validity , discriminant validity , and construct validity with confirmatory factor analysis ( CFA ) .", "sentence_id": 7}
+{"abstract_id": "25344693", "label": "results", "text": "The results of the CFA supported a six-factor model and @ items were retained in the AHP-SF with acceptable model fit .", "sentence_id": 8}
+{"abstract_id": "25344693", "label": "results", "text": "For the discriminant validity test , results indicated that adolescents with lower AHP-SF scores were more likely to be overweight or obese , skip breakfast , and spend more time watching TV and playing computer games .", "sentence_id": 9}
+{"abstract_id": "25344693", "label": "results", "text": "The AHP-SF also showed excellent internal consistency with a McDonald 's omega of @ ( Cronbach 's alpha @ ) in the calibration group .", "sentence_id": 10}
+{"abstract_id": "25344693", "label": "conclusions", "text": "The current findings suggest that the AHP-SF is a valid and reliable instrument for the evaluation of adolescent health-promoting behaviors .", "sentence_id": 11}
+{"abstract_id": "25344693", "label": "conclusions", "text": "Primary health care providers and clinicians can use the AHP-SF to assess these behaviors and evaluate the outcome of health promotion programs in the adolescent population .", "sentence_id": 12}
+{"abstract_id": "25602877", "label": "objective", "text": "We ( @ ) evaluated the impact of an evidence-based HIV prevention program with and without a parent component among mid-adolescents living in the Caribbean and ( @ ) determined the effect of prior receipt of a related intervention during preadolescence on intervention response .", "sentence_id": 0}
+{"abstract_id": "25602877", "label": "methods", "text": "A randomized , controlled @-cell trial of a @-session , theory-based HIV prevention intervention involving @ Bahamian grade-@ youths ( some of whom had received a comparable intervention in grade @ ) was conducted ( @-@ ) .", "sentence_id": 1}
+{"abstract_id": "25602877", "label": "methods", "text": "Randomization occurred at the level of the classroom with follow-up at @ , @ , and @ months after intervention .", "sentence_id": 2}
+{"abstract_id": "25602877", "label": "methods", "text": "The @ experimental conditions all included the youths ' curriculum and either a youth-parent intervention emphasizing adolescent-parent communication , a parent-only goal-setting intervention , or no parent intervention .", "sentence_id": 3}
+{"abstract_id": "25602877", "label": "results", "text": "An intervention delivered to mid-adolescents in combination with a parent-adolescent sexual-risk communication intervention increased HIV/AIDS knowledge , condom-use skills , and self-efficacy and had a marginal effect on consistent condom use .", "sentence_id": 4}
+{"abstract_id": "25602877", "label": "results", "text": "Regardless of prior exposure to a similar intervention as preadolescents , youths benefited from receipt of the intervention .", "sentence_id": 5}
+{"abstract_id": "25602877", "label": "conclusions", "text": "Preadolescents and mid-adolescents in HIV-affected countries should receive HIV prevention interventions that include parental participation .", "sentence_id": 6}
+{"abstract_id": "25175762", "label": "background", "text": "Childhood cancer survivors have an increased risk of developing cardiovascular disease following treatment , yet few interventions have been evaluated to reduce this risk .", "sentence_id": 0}
+{"abstract_id": "25175762", "label": "background", "text": "Purple grape juice ( pGJ ) , a rich source of flavonoids with antioxidant properties , has been shown in adults to reduce oxidative stress and improve endothelial function .", "sentence_id": 1}
+{"abstract_id": "25175762", "label": "background", "text": "We examined the effects of supplementing meals with pGJ on microvascular endothelial function and markers of oxidative stress and inflammation in @ cancer survivors ( ages @-@ years ) .", "sentence_id": 2}
+{"abstract_id": "25175762", "label": "methods", "text": "In a randomized controlled crossover trial consisting of two , @ week intervention periods , each preceded by a @ week washout period , subjects received in random order @ ounces twice daily of pGJ and clear apple juice ( cAJ ; similar in calories but lower in flavonoids ) .", "sentence_id": 3}
+{"abstract_id": "25175762", "label": "methods", "text": "Measurements were obtained before and after each supplementation period ; change was evaluated using mixed effects ANOVA .", "sentence_id": 4}
+{"abstract_id": "25175762", "label": "results", "text": "pGJ did not improve endothelial function , measured using digital reactive hyperemia , compared with cAJ ( mean change : pGJ @ , cAJ @ ; difference of mean change -LSB- @ % CI -RSB- : -@ -LSB- -@ - @ -RSB- , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25175762", "label": "results", "text": "No significant changes in plasma concentrations of oxidized-LDL , myeloperoxidase , or high sensitivity C-reactive protein were observed .", "sentence_id": 6}
+{"abstract_id": "25175762", "label": "conclusions", "text": "After @ weeks of daily consumption of flavonoid-rich pGJ , no measurable change in vascular function was observed in these childhood cancer survivors .", "sentence_id": 7}
+{"abstract_id": "25499753", "label": "background", "text": "The development of secondary non-response ( SNR ) to botulinum neurotoxin type-A ( BoNT-A ) is considered a key issue in the management of cervical dystonia ( CD ) .", "sentence_id": 0}
+{"abstract_id": "25499753", "label": "background", "text": "This case-controlled study was performed to systematically identify factors influencing SNR during BoNT-A therapy .", "sentence_id": 1}
+{"abstract_id": "25499753", "label": "methods", "text": "This was a retrospective , international , non-interventional study of CD patients .", "sentence_id": 2}
+{"abstract_id": "25499753", "label": "methods", "text": "Patients with SNR were matched with up to three responder patients ( control ) on the basis of duration of therapy and number of injection cycles .", "sentence_id": 3}
+{"abstract_id": "25499753", "label": "methods", "text": "Factors influencing the development of SNR were screened using a univariate logistic regression model and confirmed using a multivariate conditional logistic regression model .", "sentence_id": 4}
+{"abstract_id": "25499753", "label": "results", "text": "@ patients were enrolled , and @ ( SNR = @ ; responder = @ ) were matched and subdivided into blocks ( doublets , triplets or quadruplets ) .", "sentence_id": 5}
+{"abstract_id": "25499753", "label": "results", "text": "At baseline , a significantly higher proportion of SNR patients had received previous or concomitant therapies ( p = @ ) and surgery for CD ( p = @ ) compared with controls .", "sentence_id": 6}
+{"abstract_id": "25499753", "label": "results", "text": "Although disease severity at onset was similar between groups , a significantly higher proportion of SNR patients experienced severe CD at the time of SNR compared with controls at the last documented visit .", "sentence_id": 7}
+{"abstract_id": "25499753", "label": "results", "text": "Multivariate analyses identified five factors that were significantly associated in predicting SNR ( odds ratio -LSB- OR -RSB- > @ indicated higher chances for being SNR ) : previous surgical procedure for CD ( OR @ , p = @ ) , previous BoNT-A related severe adverse event ( AE ) ( OR @ p = @ ) , physical therapy ( OR @ , p = @ ) , neuroleptic use ( OR @ , p = @ ) and average BoNT-A dose ( OR @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25499753", "label": "conclusions", "text": "These findings suggest that SNR may not reflect true pharmacological resistance to BoNT-A therapy , but may be related to underlying disease severity .", "sentence_id": 9}
+{"abstract_id": "24908241", "label": "background", "text": "Acupuncture has been widely used as a treatment for stroke in China for more than @,@ years .", "sentence_id": 0}
+{"abstract_id": "24908241", "label": "background", "text": "However , previous research has not yet shown that acupuncture is effective as a stroke treatment .", "sentence_id": 1}
+{"abstract_id": "24908241", "label": "background", "text": "We report a protocol for a multicenter , randomized , controlled , and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on acute ischemic stroke .", "sentence_id": 2}
+{"abstract_id": "24908241", "label": "methods", "text": "In a prospective trial involving three hospitals in the Zhejiang Province ( China ) @ patients with a recent ( less than @ week previous ) episode of ischemic stroke will be included .", "sentence_id": 3}
+{"abstract_id": "24908241", "label": "methods", "text": "Patients will be randomized into two groups : an acupuncture group given scalp acupuncture and electroacupuncture , and a control group given no acupuncture .", "sentence_id": 4}
+{"abstract_id": "24908241", "label": "methods", "text": "Eighteen treatment sessions will be performed over a three-week period .", "sentence_id": 5}
+{"abstract_id": "24908241", "label": "methods", "text": "The primary outcome will be measured by changes in the National Institutes of Health Stroke Scale score at the one , three , and four-week follow-up .", "sentence_id": 6}
+{"abstract_id": "24908241", "label": "methods", "text": "Secondary outcome measures will be : @ ) the Fugl-Meyer assessment scale for motor function ; @ ) the mini-mental state examination and Montreal cognitive assessment for cognitive function ; @ ) the video-fluoroscopic swallowing study for swallowing ability ; and @ ) the incidence of adverse events .", "sentence_id": 7}
+{"abstract_id": "24908241", "label": "conclusions", "text": "This trial is expected to clarify whether or not acupuncture is effective for acute stroke .", "sentence_id": 8}
+{"abstract_id": "24908241", "label": "conclusions", "text": "It will also show if acupuncture can improve motor , cognitive , or swallowing function .", "sentence_id": 9}
+{"abstract_id": "24340290", "label": "objective", "text": "The extant literature on predictors of treatment response to behavioral treatments for insomnia is equivocal and limited in scope .", "sentence_id": 0}
+{"abstract_id": "24340290", "label": "objective", "text": "The current study examined demographic , clinical , and sleep characteristics as predictors of clinically significant treatment response to brief behavioral treatment of insomnia ( BBTI ) in older adults with insomnia .", "sentence_id": 1}
+{"abstract_id": "24340290", "label": "methods", "text": "Thirty-nine older adults with insomnia ( @ % females , mean age : @ years ) were randomized to BBTI treatment .", "sentence_id": 2}
+{"abstract_id": "24340290", "label": "methods", "text": "Treatment outcomes were defined according to @ criteria : ( @ ) `` response , '' defined as change in Pittsburgh Sleep Quality Index ( PSQI ) score @ points or increase in sleep diary sleep efficiency @ % ) ; or ( @ ) remission , defined as absence of a clinical diagnosis of insomnia according to standard diagnostic criteria .", "sentence_id": 3}
+{"abstract_id": "24340290", "label": "methods", "text": "Logistic regression examined whether baseline demographic , clinical , or sleep characteristics predicted treatment outcomes at @ month follow-up .", "sentence_id": 4}
+{"abstract_id": "24340290", "label": "results", "text": "Demographic variables did not predict treatment outcomes for either criterion .", "sentence_id": 5}
+{"abstract_id": "24340290", "label": "results", "text": "Higher anxiety , depression , poorer sleep quality , and longer polysomnography ( PSG ) - assessed sleep latency predicted greater likelihood of response at follow-up ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24340290", "label": "results", "text": "Longer sleep duration at baseline ( measured by sleep diary and PSG ) predicted greater likelihood of the remission at follow-up ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24340290", "label": "conclusions", "text": "Patients with insomnia who have greater distress at baseline or prolonged sleep latency are more likely to show positive response to BBTI .", "sentence_id": 8}
+{"abstract_id": "24340290", "label": "conclusions", "text": "In contrast , short sleepers at baseline are less likely to have resolution of insomnia diagnosis following BBTI , perhaps due to the sleep restriction component of the treatment .", "sentence_id": 9}
+{"abstract_id": "24340290", "label": "conclusions", "text": "Identifying the characteristics that predict positive BBTI treatment outcomes can facilitate personalized behavioral treatments to improve outcomes .", "sentence_id": 10}
+{"abstract_id": "25271116", "label": "objective", "text": "To compare the effects on health-related quality of life ( HRQoL ) of a @-year intervention with a low-fat diet ( LFD ) or a low-carbohydrate diet ( LCD ) based on four group-meetings to achieve compliance .", "sentence_id": 0}
+{"abstract_id": "25271116", "label": "objective", "text": "To describe different aspects of taking part in the intervention following the LFD or LCD .", "sentence_id": 1}
+{"abstract_id": "25271116", "label": "methods", "text": "Prospective , randomized trial of @ adults with Type @ diabetes mellitus .", "sentence_id": 2}
+{"abstract_id": "25271116", "label": "methods", "text": "The SF-@ questionnaire was used at baseline , @ , @ and @ months .", "sentence_id": 3}
+{"abstract_id": "25271116", "label": "methods", "text": "Patients on LFD aimed for @-@ energy percent ( E % ) and those on LCD for @ E % from carbohydrates .", "sentence_id": 4}
+{"abstract_id": "25271116", "label": "methods", "text": "The patients were interviewed about their experiences of the intervention .", "sentence_id": 5}
+{"abstract_id": "25271116", "label": "results", "text": "Mean body-mass-index was @ @ kg/m ( @ ) at baseline .", "sentence_id": 6}
+{"abstract_id": "25271116", "label": "results", "text": "Weight-loss did not differ between groups and was maximal at @ months , LFD : -@ @ kg , LCD : -@ @ kg ( p < @ within groups ) .", "sentence_id": 7}
+{"abstract_id": "25271116", "label": "results", "text": "There was an increase in the physical component score of SF-@ from @ ( @ ) to @ ( @ ) at @ months in the LCD group ( p < @ ) while no change occurred in the LFD group ( p < @ between groups ) .", "sentence_id": 8}
+{"abstract_id": "25271116", "label": "results", "text": "At @ months the physical function , bodily pain and general health scores improved within the LCD group ( p values @-@ @ ) while there was no change within the LFD group .", "sentence_id": 9}
+{"abstract_id": "25271116", "label": "conclusions", "text": "Weight-changes did not differ between the diet groups while improvements in HRQoL only occurred after one year during treatment with LCD .", "sentence_id": 10}
+{"abstract_id": "25271116", "label": "conclusions", "text": "No changes of HRQoL occurred in the LFD group in spite of a similar reduction in body weight .", "sentence_id": 11}
+{"abstract_id": "24722261", "label": "background", "text": "Antifibrinolytics have been used for @ decades to reduce bleeding in cardiac surgery .", "sentence_id": 0}
+{"abstract_id": "24722261", "label": "background", "text": "MDCO-@ is a novel , synthetic , serine protease inhibitor .", "sentence_id": 1}
+{"abstract_id": "24722261", "label": "background", "text": "We describe the first experience with this drug in patients .", "sentence_id": 2}
+{"abstract_id": "24722261", "label": "methods", "text": "In this phase II , double-blind , placebo-controlled study , @ patients undergoing isolated primary coronary artery bypass grafting with cardiopulmonary bypass were randomly assigned to @ of @ increasing dosage groups of MDCO-@ .", "sentence_id": 3}
+{"abstract_id": "24722261", "label": "methods", "text": "The primary aim was to evaluate pharmacokinetics ( PK ) with assessment of plasmatic concentrations of the drug , short-term safety , and tolerance of MDCO-@ .", "sentence_id": 4}
+{"abstract_id": "24722261", "label": "methods", "text": "Secondary end points were influence on coagulation , chest tube drainage , and transfusion requirements .", "sentence_id": 5}
+{"abstract_id": "24722261", "label": "results", "text": "PK analysis showed linear dosage-proportional correlation between MDCO-@ infusion rate and PK parameters .", "sentence_id": 6}
+{"abstract_id": "24722261", "label": "results", "text": "Blood loss was significantly reduced in the @ highest dosage groups compared with control ( P = @ , @ and @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24722261", "label": "results", "text": "The incidence of allogeneic blood product transfusions was lower with MDCO-@ @/@ ( @ % ) vs @/@ ( @ % ) in the control group .", "sentence_id": 8}
+{"abstract_id": "24722261", "label": "results", "text": "MDCO-@ exhibited dosage-dependent antifibrinolytic effects through suppression of D-dimer generation and inhibition of tissue plasminogen activator-induced lysis in ROTEM analysis as well as anticoagulant effects demonstrated by prolongation of activated clotting time and activated partial thromboplastin time .", "sentence_id": 9}
+{"abstract_id": "24722261", "label": "results", "text": "No systematic differences in markers of end organ function were observed among treatment groups .", "sentence_id": 10}
+{"abstract_id": "24722261", "label": "results", "text": "Three patients in the MDCO-@ groups experienced serious adverse events .", "sentence_id": 11}
+{"abstract_id": "24722261", "label": "results", "text": "One patient experienced intraoperative thrombosis of venous grafts considered possibly related to the study drug .", "sentence_id": 12}
+{"abstract_id": "24722261", "label": "results", "text": "No reexploration for mediastinal bleeding was required , and there were no deaths .", "sentence_id": 13}
+{"abstract_id": "24722261", "label": "conclusions", "text": "This first-in-patient study demonstrated dosage-proportional PK for MDCO-@ and reduction of chest tube drainage and transfusions in patients undergoing primary coronary artery bypass grafting .", "sentence_id": 14}
+{"abstract_id": "24722261", "label": "conclusions", "text": "Antifibrinolytic and anticoagulant effects were demonstrated using various markers of coagulation .", "sentence_id": 15}
+{"abstract_id": "24722261", "label": "conclusions", "text": "MDCO-@ was well tolerated and showed an acceptable initial safety profile .", "sentence_id": 16}
+{"abstract_id": "24722261", "label": "conclusions", "text": "Larger multi-institutional studies are warranted to further investigate the safety and efficacy of this compound .", "sentence_id": 17}
+{"abstract_id": "24311644", "label": "background", "text": "In patients with brain tumors , the choice of antiepileptic medication is guided by tolerability and pharmacokinetic interactions .", "sentence_id": 0}
+{"abstract_id": "24311644", "label": "background", "text": "This study investigated the effectiveness of levetiracetam ( LEV ) and pregabalin ( PGB ) , @ non-enzyme-inducing agents , in this setting .", "sentence_id": 1}
+{"abstract_id": "24311644", "label": "methods", "text": "In this pragmatic , randomized , unblinded phase II trial ( NCT@ ) , patients with primary brain tumors and epilepsy were titrated to a monotherapy of LEV or PGB .", "sentence_id": 2}
+{"abstract_id": "24311644", "label": "methods", "text": "Efficacy and tolerability were assessed using structured questionnaires .", "sentence_id": 3}
+{"abstract_id": "24311644", "label": "methods", "text": "The primary composite endpoint was the need to discontinue the study drug , add-on of a further antiepileptic treatment , or occurrence of at least @ seizures with impaired consciousness during @ year follow-up .", "sentence_id": 4}
+{"abstract_id": "24311644", "label": "results", "text": "Over @ months , @ patients were randomized to LEV , and @ to PGB .", "sentence_id": 5}
+{"abstract_id": "24311644", "label": "results", "text": "Most were middle-aged men , with a high-grade tumor and at least one generalized convulsion .", "sentence_id": 6}
+{"abstract_id": "24311644", "label": "results", "text": "Mean daily doses were @ mg ( LEV ) and @ mg ( PGB ) .", "sentence_id": 7}
+{"abstract_id": "24311644", "label": "results", "text": "Retention rates were @ % in the LEV group , and @ % in the PGB group .", "sentence_id": 8}
+{"abstract_id": "24311644", "label": "results", "text": "The composite endpoint was reached in @ LEV and @ PGB patients-need to discontinue : side effects , @ LEV , @ PGB ; lack of efficacy , @ and @ ; impaired oral administration , @ and @ ; add-on of another agent : @ LEV , @ PGB ; and seizures impairing consciousness : @ in each .", "sentence_id": 9}
+{"abstract_id": "24311644", "label": "results", "text": "Seven LEV and @ PGB subjects died of tumor progression .", "sentence_id": 10}
+{"abstract_id": "24311644", "label": "conclusions", "text": "This study shows that LEV and PGB represent valuable monotherapy options in this setting , with very good antiepileptic efficacy and an acceptable tolerability profile , and provides important data for the design of a phase III trial .", "sentence_id": 11}
+{"abstract_id": "24268590", "label": "background", "text": "Influenza causes substantial morbidity and mortality worldwide .", "sentence_id": 0}
+{"abstract_id": "24268590", "label": "background", "text": "Few data exist for the efficacy of neuraminidase inhibitors , which are the only readily available influenza treatment options , especially in low-income settings .", "sentence_id": 1}
+{"abstract_id": "24268590", "label": "background", "text": "We assessed the efficacy of treatment with the neuraminidase inhibitor oseltamivir to reduce patient illness and viral shedding in people with influenza , in whom treatment was started within @ days of symptom onset , in an urban setting in Bangladesh .", "sentence_id": 2}
+{"abstract_id": "24268590", "label": "methods", "text": "We undertook a double-blind , randomised , controlled trial between May , @ , and December , @ .", "sentence_id": 3}
+{"abstract_id": "24268590", "label": "methods", "text": "Patients with a positive rapid influenza test identified by surveillance of households in Kamalapur , Bangladesh were randomly allocated on a @:@ basis to receive oseltamivir or placebo twice daily for @ days .", "sentence_id": 4}
+{"abstract_id": "24268590", "label": "methods", "text": "Randomisation lists for individuals enrolled less than @ h and @ h or longer since illness onset were generated with permuted blocks of variable length between two and eight .", "sentence_id": 5}
+{"abstract_id": "24268590", "label": "methods", "text": "Participants and study staff were masked to treatment group .", "sentence_id": 6}
+{"abstract_id": "24268590", "label": "methods", "text": "Participants provided nasal wash specimens at enrolment and @ , @ , and @ days later , and were visited daily to record symptoms .", "sentence_id": 7}
+{"abstract_id": "24268590", "label": "methods", "text": "All specimens were tested for influenza with reverse-transcriptase PCR , and if the result was positive , we isolated the virus .", "sentence_id": 8}
+{"abstract_id": "24268590", "label": "methods", "text": "The primary endpoints were duration of clinical illness and viral shedding in patients treated less than and more than @ h since illness onset and the frequency of oseltamivir resistance during treatment .", "sentence_id": 9}
+{"abstract_id": "24268590", "label": "methods", "text": "Analyses were intention to treat unless otherwise specified .", "sentence_id": 10}
+{"abstract_id": "24268590", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 11}
+{"abstract_id": "24268590", "label": "results", "text": "Overall , @ people with a median age of @ years ( IQR @-@ ) were enrolled : @ ( @ % ) less than @ h since symptom onset and @ ( @ % ) @ h or longer since symptom onset .", "sentence_id": 12}
+{"abstract_id": "24268590", "label": "results", "text": "@ participants were assigned to placebo and @ to oseltamivir .", "sentence_id": 13}
+{"abstract_id": "24268590", "label": "results", "text": "The median duration of symptoms was shorter in the oseltamivir group ( @ days , IQR @-@ ) than in the placebo group ( @ days , @-@ ; p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24268590", "label": "results", "text": "When stratified by timing of treatment initiation , in participants enrolled @ h or longer since illness onset , the median duration of symptoms was similar in both groups ( oseltamivir @ days -LSB- IQR @-@ -RSB- , placebo @ days -LSB- @-@ -RSB- ; p = @ ) .", "sentence_id": 15}
+{"abstract_id": "24268590", "label": "results", "text": "The median duration of symptoms was reduced by @ day in the group given oseltamivir who were enrolled less than @ h since symptom onset compared with those given placebo , but this difference was not significant .", "sentence_id": 16}
+{"abstract_id": "24268590", "label": "results", "text": "In those with all swab specimens ( n = @ ) , oseltamivir significantly reduced virus isolation on days @ ( placebo @ -LSB- @ % -RSB- vs oseltamivir @ -LSB- @ % -RSB- ; difference @ % , @ % CI @-@ @ , p = @ ) , @ ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; difference @ % , @ % CI @-@ @ , p < @ ) , and @ ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; difference @ % , @ % CI @-@ @ , p = @ ) .", "sentence_id": 17}
+{"abstract_id": "24268590", "label": "results", "text": "In participants enrolled @ h or longer since illness onset , oseltamivir treatment significantly reduced virus isolation on days @ and @ , but not day @ .", "sentence_id": 18}
+{"abstract_id": "24268590", "label": "results", "text": "In participants enrolled less than @ h since illness onset , oseltamivir treatment significantly reduced virus isolation on days @ , @ , and @ .", "sentence_id": 19}
+{"abstract_id": "24268590", "label": "results", "text": "The emergency of resistance to oseltamivir during treatment was rare overall ( < @ % ) and in influenza A H@N@pdm@ viruses ( @ % ) .", "sentence_id": 20}
+{"abstract_id": "24268590", "label": "conclusions", "text": "Oseltamivir treatment resulted in a modest reduction in the duration of symptoms and virus shedding in people with uncomplicated influenza infections , even when treatment was started @ h or longer after illness onset .", "sentence_id": 21}
+{"abstract_id": "24885549", "label": "background", "text": "The severity and course of spinal pain is poorly understood in adolescents .", "sentence_id": 0}
+{"abstract_id": "24885549", "label": "background", "text": "The study aimed to determine the prevalence and two-year incidence , as well as the course , frequency , and intensity of pain in the neck , mid back , and low back ( spinal pain ) .", "sentence_id": 1}
+{"abstract_id": "24885549", "label": "methods", "text": "This study was a school-based prospective cohort study .", "sentence_id": 2}
+{"abstract_id": "24885549", "label": "methods", "text": "All @th and @th grade students ( @-@ years ) at @ schools in the Region of Southern Denmark were invited to participate ( N = @,@ ) .", "sentence_id": 3}
+{"abstract_id": "24885549", "label": "methods", "text": "Data were collected in @ and again two years later , using an e-survey completed during school time .", "sentence_id": 4}
+{"abstract_id": "24885549", "label": "results", "text": "The lifetime prevalence of spinal pain was @ % and @ % at baseline and follow-up , respectively .", "sentence_id": 5}
+{"abstract_id": "24885549", "label": "results", "text": "A group of @ % ( @ % CI : @ , @ ) at baseline and @ % ( @ % CI : @ , @ ) at follow-up reported that they had pain frequently .", "sentence_id": 6}
+{"abstract_id": "24885549", "label": "results", "text": "The frequency of pain was strongly associated with the intensity of pain , i.e. , the majority of the participants reported their pain as relatively infrequent and of low intensity , whereas the participants with frequent pain also experienced pain of higher intensity .", "sentence_id": 7}
+{"abstract_id": "24885549", "label": "results", "text": "The two-year incidence of spinal pain varied between @ % and @ % across the physical locations .", "sentence_id": 8}
+{"abstract_id": "24885549", "label": "results", "text": "Progression of pain from one to more locations and from infrequent to more frequent was common over the two-year period .", "sentence_id": 9}
+{"abstract_id": "24885549", "label": "conclusions", "text": "Spinal pain is common at the age of @-@ years , but some have more pain than others .", "sentence_id": 10}
+{"abstract_id": "24885549", "label": "conclusions", "text": "The pain is likely to progress , i.e. , to more locations , higher frequency , and higher pain intensity over a two-year period .", "sentence_id": 11}
+{"abstract_id": "24564308", "label": "objective", "text": "To evaluate the cardiorespiratory effects of IV administration of propofol ( @ mg/kg ) , ketamine hydrochloride and propofol ( @ mg/kg each ; K-P ) , or ketamine hydrochloride ( @ mg/kg ) and diazepam ( @ mg/kg ; K-D ) before and after induction of anesthesia ( IoA ) in dogs sedated with acepromazine maleate and oxymorphone hydrochloride .", "sentence_id": 0}
+{"abstract_id": "24564308", "label": "methods", "text": "@ healthy adult Beagles .", "sentence_id": 1}
+{"abstract_id": "24564308", "label": "methods", "text": "Each dog was randomly allocated to receive @ of @ treatments ( @-week interval ) .", "sentence_id": 2}
+{"abstract_id": "24564308", "label": "methods", "text": "For instrumentation prior to each treatment , each dog was anesthetized with isoflurane .", "sentence_id": 3}
+{"abstract_id": "24564308", "label": "methods", "text": "After full recovery , acepromazine ( @ mg/kg ) and oxymorphone ( @ mg/kg ) were administered IV .", "sentence_id": 4}
+{"abstract_id": "24564308", "label": "methods", "text": "Fifteen minutes later ( before IoA ) , each dog received treatment IV with propofol , K-P , or K-D .", "sentence_id": 5}
+{"abstract_id": "24564308", "label": "methods", "text": "Cardiorespiratory and arterial blood gas variables were assessed before , immediately after , and @ minutes after IoA .", "sentence_id": 6}
+{"abstract_id": "24564308", "label": "results", "text": "Compared with findings before IoA , dogs receiving the K-P or K-D treatment had increased cardiac output , oxygen delivery , and heart rate @ minutes after IoA ; K-P administration did not change mean arterial blood pressure or stroke volume and decreased systemic vascular resistance .", "sentence_id": 7}
+{"abstract_id": "24564308", "label": "results", "text": "Propofol decreased mean arterial blood pressure and systemic vascular resistance immediately after IoA but did not change heart rate , cardiac output , or oxygen delivery .", "sentence_id": 8}
+{"abstract_id": "24564308", "label": "results", "text": "All treatments caused some degree of apnea , hypoventilation , and hypoxemia ( Pao@ < @ mm Hg ) .", "sentence_id": 9}
+{"abstract_id": "24564308", "label": "conclusions", "text": "In dogs , K-P treatment maintained mean arterial blood pressure better than propofol alone and increased heart rate , cardiac output , or oxygen delivery , as did the K-D treatment .", "sentence_id": 10}
+{"abstract_id": "24564308", "label": "conclusions", "text": "Supplemental @ % oxygen should be provided during IoA with all @ treatments .", "sentence_id": 11}
+{"abstract_id": "25531993", "label": "objective", "text": "Antibiotic resistance is the main reason for failure of Helicobacter pylori ( H. pylori ) treatment .", "sentence_id": 0}
+{"abstract_id": "25531993", "label": "objective", "text": "Currently , guidelines recommend a treatment guided by antimicrobial susceptibility testing after two failures .", "sentence_id": 1}
+{"abstract_id": "25531993", "label": "objective", "text": "However , microbial culture is not feasible everywhere , and the limited number of effective antibiotics against the bacterium narrows the options ; thus a rescue therapy combining antibiotics with a low resistance may be fitting .", "sentence_id": 2}
+{"abstract_id": "25531993", "label": "methods", "text": "Patients who have failed a first-line treatment ( either prolonged triple or sequential regimens ) and , successively , a levofloxacin-based triple therapy were considered for the study .", "sentence_id": 3}
+{"abstract_id": "25531993", "label": "methods", "text": "Subjects underwent urea breath test ( UBT ) , stool antigen test ( ST ) and endoscopy/histology to confirm the diagnosis .", "sentence_id": 4}
+{"abstract_id": "25531993", "label": "methods", "text": "Cytopenia and impaired liver and kidney function were exclusion criteria .", "sentence_id": 5}
+{"abstract_id": "25531993", "label": "methods", "text": "Fifty-four subjects were randomized @:@ to two regimens : RMB Rabeprazole/Rifabutin/Minocycline / Bismuth sub-citrate or MTB Rabeprazole/Tinidazole/Minocycline / Bismuth sub-citrate both for @ days .", "sentence_id": 6}
+{"abstract_id": "25531993", "label": "methods", "text": "The results were checked @ weeks after the end of therapy with ST/UBT plus endoscopy when indicated .", "sentence_id": 7}
+{"abstract_id": "25531993", "label": "results", "text": "RMB eradicated the bacterium in @ patients .", "sentence_id": 8}
+{"abstract_id": "25531993", "label": "results", "text": "Two subjects dropped out .", "sentence_id": 9}
+{"abstract_id": "25531993", "label": "results", "text": "The eradication rate was @ % ( CI @-@ @ % ) at intention-to-treat and @ % ( CI @-@ @ % ) at per-protocol analysis .", "sentence_id": 10}
+{"abstract_id": "25531993", "label": "results", "text": "MTB was successful in @ patients ( @ % , CI @-@ @ % ) .", "sentence_id": 11}
+{"abstract_id": "25531993", "label": "results", "text": "No patient withdrew from the treatment for adverse events .", "sentence_id": 12}
+{"abstract_id": "25531993", "label": "results", "text": "Drug-related side effects were reported only in @ subjects , but in all cases the treatment was carried on .", "sentence_id": 13}
+{"abstract_id": "25531993", "label": "conclusions", "text": "The association minocycline/rifabutin seems to have a synergic effect and a good therapeutic outcome in patients who have failed at least two previous regimens , although a trial on a large population is needed .", "sentence_id": 14}
+{"abstract_id": "25454938", "label": "objective", "text": "To assess the effect of automated adjustment of the inspired oxygen fraction ( FiO@ ) on arterial oxygen saturation ( SpO@ ) and cerebral tissue oxygen saturation ( SctO@ ) in very low birth weight infants with frequent fluctuations in oxygenation .", "sentence_id": 0}
+{"abstract_id": "25454938", "label": "methods", "text": "Fifteen infants ( median gestational age , @ weeks -LSB- range , @-@ weeks -RSB- ; median age , @ days -LSB- range , @-@ days -RSB- ) were assigned in random sequence to @ hours of automated adjustment of FiO@ or manual adjustment of FiO@ .", "sentence_id": 1}
+{"abstract_id": "25454938", "label": "methods", "text": "Primary outcome measurements were time within the SpO@ target range and the area under the curve above and below a defined SctO@ range .", "sentence_id": 2}
+{"abstract_id": "25454938", "label": "results", "text": "Percentage of time within the SpO@ target range increased during automated FiO@ control ( @ % @ % vs @ % @ % for manual ; P < @ ) .", "sentence_id": 3}
+{"abstract_id": "25454938", "label": "results", "text": "Prolonged episodes with SpO@ < @ % of > @ seconds duration ( median , @ episodes -LSB- range , @-@ -RSB- vs @ episodes -LSB- range , @-@ -RSB- ; P < @ ) and of > @ seconds duration ( median , @ episodes -LSB- range , @-@ -RSB- vs @ episodes -LSB- range , @-@ -RSB- ; P < @ ) decreased significantly during the automated period .", "sentence_id": 4}
+{"abstract_id": "25454938", "label": "results", "text": "Percentage of time with SpO@ > @ % decreased during automated control ( @ % @ % vs @ % @ % ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25454938", "label": "results", "text": "There was no significant difference in FiO@ exposure .", "sentence_id": 6}
+{"abstract_id": "25454938", "label": "results", "text": "The area ( deviation time ) below and above the defined SctO@ threshold did not differ between the @ periods ( median , @ % * seconds -LSB- range , @ % -@ % -RSB- for manual vs @ % * seconds -LSB- range , @ % -@ % -RSB- for automated ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25454938", "label": "conclusions", "text": "Automated FiO@ control in preterm infants with frequent SpO@ fluctuations significantly increased the time within the SpO@ target range and reduced the incidence of prolonged hypoxemic events compared with manual FiO@ adjustment , but did not significantly affect cerebral tissue oxygenation .", "sentence_id": 8}
+{"abstract_id": "25091790", "label": "background", "text": "In patients with severe sepsis , no randomized clinical trial has tested the concept of de-escalation of empirical antimicrobial therapy .", "sentence_id": 0}
+{"abstract_id": "25091790", "label": "background", "text": "This study aimed to compare the de-escalation strategy with the continuation of an appropriate empirical treatment in those patients .", "sentence_id": 1}
+{"abstract_id": "25091790", "label": "methods", "text": "This was a multicenter non-blinded randomized noninferiority trial of patients with severe sepsis who were randomly assigned to de-escalation or continuation of empirical antimicrobial treatment .", "sentence_id": 2}
+{"abstract_id": "25091790", "label": "methods", "text": "Recruitment began in February @ and ended in April @ in nine intensive care units ( ICUs ) in France .", "sentence_id": 3}
+{"abstract_id": "25091790", "label": "methods", "text": "Patients with severe sepsis were assigned to de-escalation ( n = @ ) or continuation of empirical antimicrobial treatment ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25091790", "label": "methods", "text": "The primary outcome was to measure the duration of ICU stay .", "sentence_id": 5}
+{"abstract_id": "25091790", "label": "methods", "text": "We defined a noninferiority margin of @ days .", "sentence_id": 6}
+{"abstract_id": "25091790", "label": "methods", "text": "If the lower boundary of the @ % confidence interval ( CI ) for the difference in patients assigned to the de-escalation group was less than @ days , as compared with that of patients assigned to the continuation group , de-escalation was considered to be noninferior to the continuation strategy .", "sentence_id": 7}
+{"abstract_id": "25091790", "label": "methods", "text": "Secondary outcomes included mortality at @ days , occurrence of organ failure , number of superinfections , and number of days with antibiotics during the ICU stay .", "sentence_id": 8}
+{"abstract_id": "25091790", "label": "results", "text": "The median duration of ICU stay was @ -LSB- interquartile range ( IQR ) @-@ -RSB- days in the de-escalation group and @ -LSB- IQR @-@ -RSB- days in the continuation group , respectively ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25091790", "label": "results", "text": "The mean difference was @ ( @ % CI -@ to @ ) .", "sentence_id": 10}
+{"abstract_id": "25091790", "label": "results", "text": "A superinfection occurred in @ ( @ % ) patients in the de-escalation group and six ( @ % ) patients in the continuation group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25091790", "label": "results", "text": "The numbers of antibiotic days were @ -LSB- @-@ -RSB- and @ -LSB- @-@ -RSB- in the de-escalation group and continuation group , respectively ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25091790", "label": "results", "text": "Mortality was similar in both groups .", "sentence_id": 13}
+{"abstract_id": "25091790", "label": "conclusions", "text": "As compared to the continuation of the empirical antimicrobial treatment , a strategy based on de-escalation of antibiotics resulted in prolonged duration of ICU stay .", "sentence_id": 14}
+{"abstract_id": "25091790", "label": "conclusions", "text": "However , it did not affect the mortality rate .", "sentence_id": 15}
+{"abstract_id": "25239172", "label": "objective", "text": "To evaluate the effect of a hamstring block for postoperative pain management using @ mL of @ % bupivacaine compared with placebo after anterior cruciate ligament ( ACL ) reconstruction with a hamstring autograft .", "sentence_id": 0}
+{"abstract_id": "25239172", "label": "methods", "text": "In a @-month period , @ patients undergoing ACL reconstruction with a hamstring autograft who all received a femoral nerve block were randomized to receive either @ mL of @ % bupivacaine or @ mL of saline water administered through a catheter into the donor-site space .", "sentence_id": 1}
+{"abstract_id": "25239172", "label": "methods", "text": "The patients and recovery staff were blinded to the treatment .", "sentence_id": 2}
+{"abstract_id": "25239172", "label": "methods", "text": "Postoperative donor-site pain was evaluated subjectively by the patients using a pain score ( Likert scale from @ to @ ) .", "sentence_id": 3}
+{"abstract_id": "25239172", "label": "methods", "text": "The pain was registered for each hour in the first @ hours and thereafter once daily for @ days .", "sentence_id": 4}
+{"abstract_id": "25239172", "label": "methods", "text": "Furthermore , the requirement for postoperative analgesic medicine was registered .", "sentence_id": 5}
+{"abstract_id": "25239172", "label": "results", "text": "The hamstring block group ( n = @ ) had significantly less pain for each of the first @ postoperative hours .", "sentence_id": 6}
+{"abstract_id": "25239172", "label": "results", "text": "The pain score was reduced from @ to @ ( @ % confidence interval , @ to @ ) ( P = @ ) in the first hour and from @ to @ ( @ % confidence interval , @ to @ ) in the sixth hour , and there was a significantly lower overall requirement for early postoperative fentanyl , reduced from a mean of @ to @ g ( P = @ ) , and morphine , reduced from a mean of @ to @ mg ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25239172", "label": "results", "text": "After @ hours , there was no difference in the pain level and use of analgesics between the @ groups .", "sentence_id": 8}
+{"abstract_id": "25239172", "label": "conclusions", "text": "With the use of a donor-site block in hamstring ACL reconstruction , the donor-site pain level , as well as the overall requirement for fentanyl and morphine , was significantly reduced in the first @ postoperative hours .", "sentence_id": 9}
+{"abstract_id": "25239172", "label": "conclusions", "text": "No effect of the donor-site block was seen after @ hours .", "sentence_id": 10}
+{"abstract_id": "25239172", "label": "methods", "text": "Level I , therapeutic , randomized controlled study .", "sentence_id": 11}
+{"abstract_id": "24424561", "label": "objective", "text": "The aim of this study was to evaluate the effect of a low tube voltage technique and hybrid iterative reconstruction ( HIR ) on image quality at @-dimensional computed tomographic angiography ( @D-CTA ) of the liver .", "sentence_id": 0}
+{"abstract_id": "24424561", "label": "methods", "text": "Before hepatic surgery , we randomly assigned @ patients ( @ women , @ men ; mean SD age , @ @ years ) who had undergone @D-CTA to @ of @ protocols ; @ patients underwent scanning under the conventional @-kilovolt ( peak ) protocol with filtered back projection ( P@ ) ; and @ patients , under an @-kilovolt ( peak ) protocol with HIR ( P@ ) .", "sentence_id": 1}
+{"abstract_id": "24424561", "label": "methods", "text": "The estimated effective radiation dose , computed tomographic attenuation , image noise , contrast-to-noise ratio , and figure of merit were calculated , and the visual image quality of @D-CTA was scored on a @-point scale .", "sentence_id": 2}
+{"abstract_id": "24424561", "label": "results", "text": "The mean effective radiation dose was significantly lower under P@ than P@ ( @ @ vs @ @ mSv , P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24424561", "label": "results", "text": "P@ and P@ did not significantly differ with respect to the image noise ( @ @ vs @ @ Hounsfield units ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24424561", "label": "results", "text": "Computed tomographic attenuation , contrast-to-noise ratio , figure of merit , and the visual scores for image quality were higher under P@ than P@ ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24424561", "label": "conclusions", "text": "The use of low tube voltage and HIR can yield significantly improved image quality at @D-CTA of the liver .", "sentence_id": 6}
+{"abstract_id": "25161019", "label": "objective", "text": "To improve arterial catheter ( AC ) securement and reduce AC failure ; to assess feasibility of a large randomised controlled trial .", "sentence_id": 0}
+{"abstract_id": "25161019", "label": "methods", "text": "A four-arm , parallel , randomised , controlled , non-blinded pilot trial with @ intensive care patients taking part , in a tertiary referral hospital in Brisbane , Australia from May to November @ .", "sentence_id": 1}
+{"abstract_id": "25161019", "label": "methods", "text": "Standard polyurethane ( SPU ) dressing ( controls ) ; bordered polyurethane ( BPU ) + SPU dressing ; tissue adhesive ( TA ) + SPU dressing ; and sutureless securement device ( SSD ) + SPU dressing ( no sutures used ) .", "sentence_id": 2}
+{"abstract_id": "25161019", "label": "methods", "text": "AC failure , ie , complete dislodgement , occlusion ( monitor failure , inability to infuse or fluid leaking ) , pain or infection ( local or blood ) .", "sentence_id": 3}
+{"abstract_id": "25161019", "label": "results", "text": "Median AC dwell time was @ hours and was comparable between groups .", "sentence_id": 4}
+{"abstract_id": "25161019", "label": "results", "text": "AC failure occurred in @/@ patients ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25161019", "label": "results", "text": "AC failure was significantly worse with SPU dressings ( @/@ -LSB- @ % -RSB- ) than with BPU + SPU dressings ( @ / @ -LSB- @ % -RSB- ; P = @ ) , but not significantly different to TA + SPU ( @/@ -LSB- @ % -RSB- ; P = @ ) or SSD + SPU ( @/@ -LSB- @ % -RSB- ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25161019", "label": "results", "text": "The dressing applied at AC insertion lasted until AC removal in @ % of controls ; @ % of BPU + SPU dressings ; @ % of TA + SPU dressings ; and @ % of SSD + SPU dressings ( all P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25161019", "label": "results", "text": "There were no infections or serious adverse events .", "sentence_id": 8}
+{"abstract_id": "25161019", "label": "results", "text": "Patient and staff satisfaction with all products was high .", "sentence_id": 9}
+{"abstract_id": "25161019", "label": "results", "text": "Median costs ( labour and materials ) for securement per patient were significantly higher in all groups compared with the control group ( SPU , $ @ -LSB- IQR , $ @ - $ @ -RSB- ; BPU + SPU , $ @ -LSB- IQR , $ @ - $ @ -RSB- ; SSD + SPU , $ @ -LSB- IQR , $ @ - $ @ -RSB- ; TA + SPU , $ @ -LSB- IQR , $ @ - $ @ -RSB- ; all P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25161019", "label": "conclusions", "text": "AC failure occurred significantly less often with BPU + SPU dressings than with SPU dressings .", "sentence_id": 11}
+{"abstract_id": "25161019", "label": "conclusions", "text": "TA + SPU and SSD + SPU dressings should be further investigated and compared with BPU + SPU dressings as controls .", "sentence_id": 12}
+{"abstract_id": "25161019", "label": "conclusions", "text": "The novel approach of TA + SPU dressings appeared safe and feasible .", "sentence_id": 13}
+{"abstract_id": "25243819", "label": "objective", "text": "To evaluate the veterinary student learning outcome of @ methods of equine rectal examination training .", "sentence_id": 0}
+{"abstract_id": "25243819", "label": "methods", "text": "Randomized prospective study .", "sentence_id": 1}
+{"abstract_id": "25243819", "label": "methods", "text": "Veterinary students ( @rd and @th year ; n = @ ) and practicing equine veterinarians ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25243819", "label": "methods", "text": "Year @ : Group @ ( n = @ ) and Group @ students ( n = @ ) received skilled instructor ( SI ) and laparoscopic-guidance ( LG ) , respectively , during rectal exam instruction .", "sentence_id": 3}
+{"abstract_id": "25243819", "label": "methods", "text": "All students were tested on rectal identification of @ abdominal organs .", "sentence_id": 4}
+{"abstract_id": "25243819", "label": "methods", "text": "Year @ : One group of students ( n = @ ) was trained and subsequently tested using each technique , first SI , followed by LG .", "sentence_id": 5}
+{"abstract_id": "25243819", "label": "methods", "text": "Subjective evaluation of laparoscopy as a teaching tool was achieved with veterinary students and equine practitioners .", "sentence_id": 6}
+{"abstract_id": "25243819", "label": "results", "text": "A significantly greater percentage of students having LG compared to SI were able to correctly identify the left kidney ( Year @ ) and the spleen , cecum , and right ovary ( Year @ ) .", "sentence_id": 7}
+{"abstract_id": "25243819", "label": "results", "text": "A significantly greater proportion of LG trained students in years @ and @ ( @ % and @ % , respectively ) were also able to identify @ % of organs compared with SI ( @ % and @ % , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25243819", "label": "results", "text": "Both students and veterinarians uniformly provided favorable feedback for LG in teaching rectal palpation skills .", "sentence_id": 9}
+{"abstract_id": "25243819", "label": "conclusions", "text": "The LG method of equine rectal examination instruction resulted in improved learning for identification of several key abdominal organs compared with SI .", "sentence_id": 10}
+{"abstract_id": "24572769", "label": "objective", "text": "We report our experience with a modified mini-maze procedure and pulmonary vein isolation using radiofrequency energy for treating persistent atrial fibrillation during coronary artery bypass grafting ( CABG ) .", "sentence_id": 0}
+{"abstract_id": "24572769", "label": "methods", "text": "Ninety-five patients with persistent atrial fibrillation and coronary heart disease underwent open heart surgery combined with intraoperative irrigated radiofrequency ablation .", "sentence_id": 1}
+{"abstract_id": "24572769", "label": "methods", "text": "Patients were randomized into the following three groups : CABG and irrigated radiofrequency pulmonary vein isolation ( CABG+PVI , n = @ ) ; CABG and an irrigated radiofrequency modified mini-maze procedure ( CABG+MM , n = @ ) ; and isolated CABG ( CABG alone , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24572769", "label": "methods", "text": "All patients received implantable loop recorders .", "sentence_id": 3}
+{"abstract_id": "24572769", "label": "results", "text": "No reoperation and no hospital mortality were recorded .", "sentence_id": 4}
+{"abstract_id": "24572769", "label": "results", "text": "Mean follow-up was @ @ months .", "sentence_id": 5}
+{"abstract_id": "24572769", "label": "results", "text": "The implantable loop recorder-determined freedom from atrial fibrillation was @ % in the CABG+PVI group , @ % in the CABG+MM group and @ % in the CABG alone group .", "sentence_id": 6}
+{"abstract_id": "24572769", "label": "conclusions", "text": "Patients with concomitant atrial fibrillation and coronary heart disease may benefit from intraoperative ablation to prevent relapse of arrhythmia .", "sentence_id": 7}
+{"abstract_id": "25042182", "label": "background", "text": "Dystrophinopathy is a rare , severe muscle disorder , and nonsense mutations are found in @ % of cases .", "sentence_id": 0}
+{"abstract_id": "25042182", "label": "background", "text": "Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation ( nm ) genetic disorders .", "sentence_id": 1}
+{"abstract_id": "25042182", "label": "methods", "text": "Randomized , double-blind , placebo-controlled study ; males @ years with nm-dystrophinopathy received study drug orally @ times daily , ataluren @ , @ , @ mg/kg ( N = @ ) ; ataluren @ , @ , @ mg/kg ( N = @ ) ; or placebo ( N = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25042182", "label": "methods", "text": "The primary endpoint was change in @-Minute Walk Distance ( @MWD ) at Week @ .", "sentence_id": 3}
+{"abstract_id": "25042182", "label": "results", "text": "Ataluren was generally well tolerated .", "sentence_id": 4}
+{"abstract_id": "25042182", "label": "results", "text": "The primary endpoint favored ataluren @ , @ , @ mg/kg versus placebo ; the week @ @MWD = @ meters , post hoc P = @ .", "sentence_id": 5}
+{"abstract_id": "25042182", "label": "results", "text": "Secondary endpoints ( timed function tests ) showed meaningful differences between ataluren @ , @ , @ mg/kg , and placebo .", "sentence_id": 6}
+{"abstract_id": "25042182", "label": "conclusions", "text": "As the first investigational new drug targeting the underlying cause of nm-dystrophinopathy , ataluren offers promise as a treatment for this orphan genetic disorder with high unmet medical need .", "sentence_id": 7}
+{"abstract_id": "25861467", "label": "objective", "text": "Increased coagulation activation may contribute to the high incidence of cardiovascular complications observed in obese and type @ diabetes ( T@D ) subjects .", "sentence_id": 0}
+{"abstract_id": "25861467", "label": "objective", "text": "Although tissue factor ( TF ) , the primary initiator of coagulation is increased in obesity , its expression in adipose tissues and its association with metabolic parameters are unclear .", "sentence_id": 1}
+{"abstract_id": "25861467", "label": "objective", "text": "We sought to compare TF expression in plasma and adipose tissues of obese subjects with and without T@D , its correlation with metabolic parameters , and regulation in response to antidiabetic drugs .", "sentence_id": 2}
+{"abstract_id": "25861467", "label": "methods", "text": "Subjects were recruited from diabetes clinics and adipose tissue was obtained by needle biopsy of lower subcutaneous abdominal depot .", "sentence_id": 3}
+{"abstract_id": "25861467", "label": "methods", "text": "For the intervention study , subjects were randomized into treatment groups with rosiglitazone or metformin for @ months .", "sentence_id": 4}
+{"abstract_id": "25861467", "label": "results", "text": "Plasma TF antigen , activity , and adipose TF mRNA were greater in obese T@D subjects compared with obese nondiabetics .", "sentence_id": 5}
+{"abstract_id": "25861467", "label": "results", "text": "Plasma TF activity correlated with fasting insulin , glucose , and free fatty acids , ( FFAs ) , and adipose TF mRNA correlated with plasma FFA .", "sentence_id": 6}
+{"abstract_id": "25861467", "label": "results", "text": "Plasma TF activity was reduced by metformin and increased with rosiglitazone treatment .", "sentence_id": 7}
+{"abstract_id": "25861467", "label": "conclusions", "text": "Specific diabetes-related metabolic parameters , but not obesity per se , are correlated with TF expression .", "sentence_id": 8}
+{"abstract_id": "25861467", "label": "conclusions", "text": "Regulation of TF activity by different classes of antidiabetic drugs may relate to protective or adverse cardiovascular outcomes .", "sentence_id": 9}
+{"abstract_id": "24715425", "label": "objective", "text": "To observe the effects of Liuwei Dihuang Granule ( -LSB- symbols ; see text -RSB- , LDG ) for tonifying Kidney ( Shen ) on the outcomes of in vitro fertilization pre-embryo transfer ( IVF-ET ) of infertility women with Kidney-yin deficiency syndrome and to explore its mechanism by detecting the proteome expression in the follicular fluid .", "sentence_id": 0}
+{"abstract_id": "24715425", "label": "methods", "text": "Sixty-six infertility patients of Kidney-yin deficiency syndrome who would undergo IVF-ET , were randomly assigned to a treatment group and a control group according to a random number table , @ cases in each group .", "sentence_id": 1}
+{"abstract_id": "24715425", "label": "methods", "text": "Another @ cases of non-Kidney-yin deficiency syndrome was taken as a syndrome-control group .", "sentence_id": 2}
+{"abstract_id": "24715425", "label": "methods", "text": "Besides Western routine therapy , LDG was given @ menstrual cycles before IVF to the treatment group , and a placebo granule to the control and syndrome-control groups .", "sentence_id": 3}
+{"abstract_id": "24715425", "label": "methods", "text": "The scores of Kidney-yin deficiency symptoms ( sore waist and knees , dry vagina , dysphoria with feverish sensation in the chest , palms and soles , etc. ) were assessed , the number of retrieved oocytes , rates of high quality oocytes and embryos , fertility rate and clinical pregnancy rate were recorded , and the follicular fluid was collected on the day when the ovum was picked up , the differential protein expression was detected using two-dimensional gel electrophoresis , and then , matrix assisted laser desorption ionization time-of flight mass spectrometry ( MALDI-TOF-MS ) was applied to identify the proteins .", "sentence_id": 4}
+{"abstract_id": "24715425", "label": "results", "text": "The syndrome score in the treatment group decreased significantly from @ to @ , while it changed insignificantly in the control group , with a significant difference in the lowering score between the two groups ( P < @ ) ; the high quality rates of oocytes and embryos and clinical pregnancy rate were all superior in the treatment group to the control group ( @ % vs @ % , @ % vs @ % , @ % vs @ % , all P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24715425", "label": "results", "text": "The protein expression map from the follicular fluid showed that compared with the control group , @ differential protein expressions were found in the syndrome-control group , among which @ were down-regulated , and @ up-regulated ; in the treatment group @ differential protein expressions were found , among which @ were down-regulated , and @ up-regulated .", "sentence_id": 6}
+{"abstract_id": "24715425", "label": "results", "text": "Through MALDI-TOF-MS , @ proteins were identified ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24715425", "label": "conclusions", "text": "For the infertility patients undergoing IVF , LDG could alleviate clinical symptoms , improve rates of high quality oocytes and embryos , so as to raise clinical pregnancy rate .", "sentence_id": 8}
+{"abstract_id": "24715425", "label": "conclusions", "text": "The mechanism may be through regulating proteome expression in the follicular fluid to improve the developmental microenvironment for oocytes which would lead to a successful embryo implantation .", "sentence_id": 9}
+{"abstract_id": "24354839", "label": "objective", "text": "We evaluated the impact of influenza vaccine text message reminders in a low-income obstetric population .", "sentence_id": 0}
+{"abstract_id": "24354839", "label": "methods", "text": "We conducted a randomized controlled trial that enrolled @ obstetric patients from @ community-based clinics in New York City .", "sentence_id": 1}
+{"abstract_id": "24354839", "label": "methods", "text": "The intervention group received @ weekly text messages regarding influenza vaccination starting mid-September @ and @ text message appointment reminders .", "sentence_id": 2}
+{"abstract_id": "24354839", "label": "methods", "text": "Both groups received standard automated telephone appointment reminders .", "sentence_id": 3}
+{"abstract_id": "24354839", "label": "methods", "text": "The prespecified endpoints were receipt of either pre - or postpartum influenza vaccination calculated cumulatively at the end of each month ( September-December @ ) .", "sentence_id": 4}
+{"abstract_id": "24354839", "label": "results", "text": "After adjusting for gestational age and number of clinic visits , women who received the intervention were @ % more likely to be vaccinated as of December @ ( adjusted odds ratio -LSB- AOR -RSB- = @ ; @ % confidence interval -LSB- CI -RSB- = @ , @ end of September : AOR = @ ; @ % CI = @ , @ ; October : AOR = @ ; @ % CI = @ , @ ; November : AOR = @ ; @ % CI = @ , @ ) .", "sentence_id": 5}
+{"abstract_id": "24354839", "label": "results", "text": "The subgroup of women early in the third trimester at randomization showed the greatest intervention effect ( December @ : @ % intervention vs @ % control ; AOR = @ ; @ % CI = @ , @ ) .", "sentence_id": 6}
+{"abstract_id": "24354839", "label": "conclusions", "text": "In this low-income obstetric population , text messaging was associated with increased influenza vaccination , especially in those who received messages early in their third trimester .", "sentence_id": 7}
+{"abstract_id": "24912060", "label": "objective", "text": "Despite the large number of Latinos living in the United States , little research has evaluated the effectiveness of different vocational rehabilitation programs for individuals with severe mental illness in this rapidly growing minority population .", "sentence_id": 0}
+{"abstract_id": "24912060", "label": "objective", "text": "This article presents a secondary analysis of a randomized , controlled trial comparing supported employment with @ other vocational rehabilitation programs in @ ethnic/racial groups of participants with severe mental illness : Latinos , non-Latino African Americans , and non-Latino Whites .", "sentence_id": 1}
+{"abstract_id": "24912060", "label": "methods", "text": "The data were drawn from a previously published randomized , controlled trial comparing supported employment with standard vocational rehabilitation services and a psychosocial clubhouse program in persons with severe mental illness ( Mueser et al. , @ ) , including @ Latinos , @ non-Latino African Americans , and @ non-Latino Whites .", "sentence_id": 2}
+{"abstract_id": "24912060", "label": "methods", "text": "Comparisons were made between the @ groups at baseline on demographic characteristics , clinical and psychosocial functioning , and quality of life .", "sentence_id": 3}
+{"abstract_id": "24912060", "label": "methods", "text": "Within each ethnic/racial group , competitive employment and all paid employment outcomes were compared between the @ vocational rehabilitation programs over the @-year study period .", "sentence_id": 4}
+{"abstract_id": "24912060", "label": "results", "text": "At baseline , the Latino participants had lower levels of education and disability income , were less likely to have worked competitively over the previous @ years , had more severe symptoms , and worse psychosocial functioning than the non-Latino African American or non-Latino White participants .", "sentence_id": 5}
+{"abstract_id": "24912060", "label": "results", "text": "Latinos randomized to supported employment had better competitive and all-paid work outcomes than those assigned to either standard services or the psychosocial clubhouse program , similar to the non-Latino consumers .", "sentence_id": 6}
+{"abstract_id": "24912060", "label": "results", "text": "Rates of competitive work for consumers in supported employment were comparable across all @ racial/ethnic groups .", "sentence_id": 7}
+{"abstract_id": "24912060", "label": "conclusions", "text": "Supported employment is effective at improving competitive work in Latinos with severe mental illness .", "sentence_id": 8}
+{"abstract_id": "24912060", "label": "conclusions", "text": "Efforts should be made to increase access to supported employment in the growing population of Latinos with severe mental illness .", "sentence_id": 9}
+{"abstract_id": "25386609", "label": "objective", "text": "A new , novel product , Cynatine HNS , was evaluated for its effects as a supplement for improving various aspects of hair and nails in a randomized , double-blind , placebo-controlled clinical trial .", "sentence_id": 0}
+{"abstract_id": "25386609", "label": "methods", "text": "A total of @ females were included and randomized into two groups .", "sentence_id": 1}
+{"abstract_id": "25386609", "label": "methods", "text": "The active group ( n = @ ) received @ capsules containing Cynatine HNS , comprised of Cynatine brand keratin ( @ mg ) plus vitamins and minerals , per day , and the placebo group ( n = @ ) received @ identical capsules of maltodextrin per day for @ days .", "sentence_id": 2}
+{"abstract_id": "25386609", "label": "methods", "text": "End points for hair loss , hair growth , hair strength , amino acid composition , and hair luster were measured .", "sentence_id": 3}
+{"abstract_id": "25386609", "label": "methods", "text": "End points were also measured for nail strength and the appearance of nails .", "sentence_id": 4}
+{"abstract_id": "25386609", "label": "results", "text": "The results show that subjects taking Cynatine HNS showed statistically significant improvements in their hair and nails when compared to placebo .", "sentence_id": 5}
+{"abstract_id": "25386609", "label": "conclusions", "text": "Cynatine HNS is an effective supplement for improving hair and nails in @ days or less .", "sentence_id": 6}
+{"abstract_id": "25386609", "label": "conclusions", "text": "EudraCT number is @-@-@ .", "sentence_id": 7}
+{"abstract_id": "25001961", "label": "background", "text": "Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition , but no currently available pharmacologic treatments reduce these deficits .", "sentence_id": 0}
+{"abstract_id": "25001961", "label": "background", "text": "The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia .", "sentence_id": 1}
+{"abstract_id": "25001961", "label": "methods", "text": "We administered @ IU of oxytocin and saline placebo intranasally to @ male subjects with schizophrenia and @ age-matched , healthy controls in a randomized , double-blind , placebo-controlled , cross-over study .", "sentence_id": 2}
+{"abstract_id": "25001961", "label": "methods", "text": "Social cognition was assessed with The Awareness of Social Inference Test ( TASIT ) and the Reading the Mind in the Eyes Test ( RMET ) .", "sentence_id": 3}
+{"abstract_id": "25001961", "label": "methods", "text": "We examined the effects of oxytocin administration on automatic social cognition ( the ability to rapidly interpret and understand emotional cues from the voice , face , and body ) ; controlled social cognition ( the ability to comprehend indirectly expressed emotions , thoughts , and intentions through complex deliberations over longer time periods ) ; and a control task ( the ability to comprehend truthful dialog and perform general task procedures ) in individuals with and without schizophrenia using mixed factorial analysis of variance models .", "sentence_id": 4}
+{"abstract_id": "25001961", "label": "results", "text": "Patients with schizophrenia showed significant impairments in automatic and controlled social cognition compared to healthy controls , and administration of oxytocin significantly improved their controlled , but not automatic , social cognition , F ( @ , @ ) = @ ; p = @ .", "sentence_id": 5}
+{"abstract_id": "25001961", "label": "results", "text": "Conversely , oxytocin administration had limited effects on social cognition in healthy participants .", "sentence_id": 6}
+{"abstract_id": "25001961", "label": "results", "text": "Patients and controls performed equally well and there were no effects of oxytocin administration on the control task .", "sentence_id": 7}
+{"abstract_id": "25001961", "label": "conclusions", "text": "Intact social cognitive abilities are associated with better functional outcomes in individuals with schizophrenia .", "sentence_id": 8}
+{"abstract_id": "25001961", "label": "conclusions", "text": "Our data highlight the potentially complex effects of oxytocin on some but not all aspects of social cognition , and support the exploration of intranasal oxytocin as a potential adjunct treatment to improve controlled social cognition in schizophrenia .", "sentence_id": 9}
+{"abstract_id": "25311600", "label": "objective", "text": "To investigate associations between timing of adiposity rebound ( AR ; the period in childhood where BMI begins to increase from its nadir ) and adiposity ( BMI , fat mass ) at age @ years in the Avon Longitudinal Study of Parents and Children ( ALSPAC ) .", "sentence_id": 0}
+{"abstract_id": "25311600", "label": "methods", "text": "The sample consisted of @ children with AR derived in childhood and BMI and fat mass index ( FMI ; fat mass measured by dual-energy radiograph absorptiometry/height in m ( @ ) ) measured at @ years .", "sentence_id": 1}
+{"abstract_id": "25311600", "label": "methods", "text": "Multivariable linear regression models were based on standardized residuals of log BMI and log FMI to allow comparison of regression coefficients across outcomes .", "sentence_id": 2}
+{"abstract_id": "25311600", "label": "results", "text": "There were strong dose-response associations between timing of AR and both adiposity outcomes at @ years independent of confounders .", "sentence_id": 3}
+{"abstract_id": "25311600", "label": "results", "text": "BMI was markedly higher in adolescence for those with very early AR ( by @ years ; = @ ; @ % confidence interval -LSB- CI -RSB- : @-@ @ ; P @ ) and was also higher for those with early AR ( between @ and @ years ; = @ ; @ % CI : @-@ @ ; P = @ ) compared with those with later AR ( > @ years ) after full adjustment for a range of potential confounders .", "sentence_id": 4}
+{"abstract_id": "25311600", "label": "results", "text": "Similar magnitudes of association were found for FMI after full adjustment for confounders ( compared with later AR : very early AR = @ ; @ % CI : @-@ @ ; P @ ; early AR = @ ; @ % CI : @-@ @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25311600", "label": "conclusions", "text": "Early AR is strongly associated with increased BMI and FMI in adolescence .", "sentence_id": 6}
+{"abstract_id": "25311600", "label": "conclusions", "text": "Preventive interventions should consider targeting modifiable factors in early childhood to delay timing of AR .", "sentence_id": 7}
+{"abstract_id": "24568258", "label": "methods", "text": "Randomized clinical trial .", "sentence_id": 0}
+{"abstract_id": "24568258", "label": "objective", "text": "To compare the effects of functional stabilization training ( FST ) versus standard training on knee pain and function , lower-limb and trunk kinematics , trunk muscle endurance , and eccentric hip and knee muscle strength in women with patellofemoral pain .", "sentence_id": 1}
+{"abstract_id": "24568258", "label": "background", "text": "A combination of hip - and knee-strengthening exercise may be more beneficial than quadriceps strengthening alone to improve pain and function in individuals with patellofemoral pain .", "sentence_id": 2}
+{"abstract_id": "24568258", "label": "background", "text": "However , there is limited evidence of the effectiveness of these exercise programs on the biomechanics of the lower extremity .", "sentence_id": 3}
+{"abstract_id": "24568258", "label": "methods", "text": "Thirty-one women were randomized to either the FST group or standard-training group .", "sentence_id": 4}
+{"abstract_id": "24568258", "label": "methods", "text": "Patients attended a baseline assessment session , followed by an @-week intervention , and were reassessed at the end of the intervention and at @ months after the intervention .", "sentence_id": 5}
+{"abstract_id": "24568258", "label": "methods", "text": "Assessment measures were a @-cm visual analog scale for pain , the Lower Extremity Functional Scale , and the single-leg triple-hop test .", "sentence_id": 6}
+{"abstract_id": "24568258", "label": "methods", "text": "A global rating of change scale was used to measure perceived improvement .", "sentence_id": 7}
+{"abstract_id": "24568258", "label": "methods", "text": "Kinematics were assessed during the single-leg squat .", "sentence_id": 8}
+{"abstract_id": "24568258", "label": "methods", "text": "Outcome measures also included trunk endurance and eccentric hip and knee muscle strength assessment .", "sentence_id": 9}
+{"abstract_id": "24568258", "label": "results", "text": "The patients in the FST group had less pain at the @-month follow-up and greater global improvement and physical function at the end of the intervention compared to those in the standard-training group .", "sentence_id": 10}
+{"abstract_id": "24568258", "label": "results", "text": "Lesser ipsilateral trunk inclination , pelvis contralateral depression , hip adduction , and knee abduction , along with greater pelvis anteversion and hip flexion movement excursions during the single-leg squat , were only observed in the FST group after the intervention .", "sentence_id": 11}
+{"abstract_id": "24568258", "label": "results", "text": "Only those in the FST group had greater eccentric hip abductor and knee flexor strength , as well as greater endurance of the anterior , posterior , and lateral trunk muscles , after training .", "sentence_id": 12}
+{"abstract_id": "24568258", "label": "conclusions", "text": "An intervention program consisting of hip muscle strengthening and lower-limb and trunk movement control exercises was more beneficial in improving pain , physical function , kinematics , and muscle strength compared to a program of quadriceps-strengthening exercises alone .", "sentence_id": 13}
+{"abstract_id": "24532685", "label": "objective", "text": "To evaluate the @-year results following a randomised controlled trial ( RCT ) comparing open ( ONF ) and laparoscopic ( LNF ) Nissen fundoplication in children .", "sentence_id": 0}
+{"abstract_id": "24532685", "label": "background", "text": "It is assumed that long-term results of ONF and LNF are comparable .", "sentence_id": 1}
+{"abstract_id": "24532685", "label": "background", "text": "No randomised studies have been performed in children .", "sentence_id": 2}
+{"abstract_id": "24532685", "label": "methods", "text": "A follow-up study was performed in children randomised to ONF or LNF ( clinicaltrials.gov identifier NCT@ ) .", "sentence_id": 3}
+{"abstract_id": "24532685", "label": "methods", "text": "Recurrent gastro-oesophageal reflux ( GER ) was documented by upper gastrointestinal contrast study and/or @-h pH study .", "sentence_id": 4}
+{"abstract_id": "24532685", "label": "methods", "text": "Nutritional status , retching and other symptoms were investigated .", "sentence_id": 5}
+{"abstract_id": "24532685", "label": "methods", "text": "A questionnaire was used to assess the quality of life before and after surgery .", "sentence_id": 6}
+{"abstract_id": "24532685", "label": "results", "text": "Thirty-nine children were randomised to ONF ( n = @ ) or LNF ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "24532685", "label": "results", "text": "There were @ ONF and @ LNF neurologically impaired children .", "sentence_id": 8}
+{"abstract_id": "24532685", "label": "results", "text": "One patient ( ONF group ) was lost to follow-up .", "sentence_id": 9}
+{"abstract_id": "24532685", "label": "results", "text": "Follow-up was @ years ( @-@ @ ) for ONF group and @ years ( @-@ @ ) for LNF group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24532685", "label": "results", "text": "Seven neurologically impaired children had died by the time of follow-up ( @ ONF , @ LNF ) .", "sentence_id": 11}
+{"abstract_id": "24532685", "label": "results", "text": "Incidence of recurrent GER was @ % in the ONF and @ % in the LNF ( p = ns ) .", "sentence_id": 12}
+{"abstract_id": "24532685", "label": "results", "text": "One patient in each group underwent redo-Nissen fundoplication .", "sentence_id": 13}
+{"abstract_id": "24532685", "label": "results", "text": "Nutritional status improved in both groups , as indicated by a significant increase in weight Z-score ( p < @ ) .", "sentence_id": 14}
+{"abstract_id": "24532685", "label": "results", "text": "Gas bloat and dumping syndrome were present in both groups ( p = ns ) .", "sentence_id": 15}
+{"abstract_id": "24532685", "label": "results", "text": "Incidence of retching was lower in the laparoscopic group ( p = @ ) .", "sentence_id": 16}
+{"abstract_id": "24532685", "label": "results", "text": "Quality of life improved in both groups ( p = ns ) .", "sentence_id": 17}
+{"abstract_id": "24532685", "label": "conclusions", "text": "Open and laparoscopic Nissen provide similar control of reflux and quality of life at follow-up .", "sentence_id": 18}
+{"abstract_id": "24532685", "label": "conclusions", "text": "LNF is associated with reduced incidence of retching persisting at @-year follow-up .", "sentence_id": 19}
+{"abstract_id": "26150444", "label": "objective", "text": "To determine the efficacy of consolidation chemotherapy ( CC ) with docetaxel and cisplatin ( DP ) after concurrent chemoradiotherapy ( CCRT ) with the same agents in locally advanced non-small-cell lung cancer ( LA-NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "26150444", "label": "methods", "text": "Patients were randomly assigned to either CCRT alone ( observation arm ) or CCRT followed by CC ( consolidation arm ) .", "sentence_id": 1}
+{"abstract_id": "26150444", "label": "methods", "text": "CCRT with docetaxel ( @ mg/m ( @ ) ) and cisplatin ( @ mg/m ( @ ) ) was administered every week for @ weeks with a total dose of @ Gy of thoracic radiotherapy in @ fractions .", "sentence_id": 2}
+{"abstract_id": "26150444", "label": "methods", "text": "In the consolidation arm , patients were further treated with three cycles of DP ( @ mg/m ( @ ) each on days @ and @ , every @ weeks ) .", "sentence_id": 3}
+{"abstract_id": "26150444", "label": "methods", "text": "The primary end point was @ % improvement in progression-free survival ( PFS ) compared with observation .", "sentence_id": 4}
+{"abstract_id": "26150444", "label": "results", "text": "From October @ to April @ , @ patients were randomly assigned .", "sentence_id": 5}
+{"abstract_id": "26150444", "label": "results", "text": "Seventeen patients did not start CCRT as a result of consent withdrawal or ineligibility reasons after random assignment , leaving @ patients for this analysis ( n = @ for observation ; n = @ for consolidation ) .", "sentence_id": 6}
+{"abstract_id": "26150444", "label": "results", "text": "Patient characteristics were similar in both arms .", "sentence_id": 7}
+{"abstract_id": "26150444", "label": "results", "text": "In the consolidation arm , @ patients ( @ % ) received CC , of whom @ ( @ % ) completed three planned cycles .", "sentence_id": 8}
+{"abstract_id": "26150444", "label": "results", "text": "The median PFS was @ months in the observation arm and @ months in the consolidation arm ( hazard ratio , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26150444", "label": "results", "text": "Median overall survival times were @ and @ months in the observation and consolidation arms , respectively ( HR , @ ; @ % CI , @ to @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26150444", "label": "conclusions", "text": "CC with DP after CCRT with weekly DP in LA-NSCLC failed to further prolong PFS .", "sentence_id": 11}
+{"abstract_id": "26150444", "label": "conclusions", "text": "CCRT alone should remain the standard of care .", "sentence_id": 12}
+{"abstract_id": "25200354", "label": "background", "text": "In mainland China , peginterferon ( PEG-IFN ) alfa-@b @ g/kg/wk for @ weeks is the approved treatment for HBeAg-positive chronic hepatitis B.", "sentence_id": 0}
+{"abstract_id": "25200354", "label": "objective", "text": "This multicenter , randomized trial evaluated the safety and efficacy of regimens utilizing increased dose or treatment duration in treatment-naive Chinese patients with chronic hepatitis B.", "sentence_id": 1}
+{"abstract_id": "25200354", "label": "methods", "text": "@ HBeAg-positive patients from China , Malaysia , Taiwan area , Singapore , and Thailand were enrolled .", "sentence_id": 2}
+{"abstract_id": "25200354", "label": "methods", "text": "Patients received PEG-IFN alfa-@b @ g/kg/wk ( arm A ) or @ g/kg/wk ( arm B ) for @ weeks , or @ g/kg/wk for @ weeks ( arm C ) .", "sentence_id": 3}
+{"abstract_id": "25200354", "label": "methods", "text": "The primary end point was loss of HBeAg @ weeks after end of treatment .", "sentence_id": 4}
+{"abstract_id": "25200354", "label": "results", "text": "At the end of follow-up , HBeAg loss was significantly greater in arm C compared with arm A ( @ % vs. @ % ; P = @ ) and arm B ( @ % vs. @ % ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25200354", "label": "results", "text": "No significant difference in the rate of HBeAg loss was observed between arms A and B.", "sentence_id": 6}
+{"abstract_id": "25200354", "label": "results", "text": "The proportions of patients with HBe seroconversion , HBV DNA levels < @,@ IU/mL , and ALT normalization at the end of follow-up were significantly higher in arm C compared with arm A and arm B.", "sentence_id": 7}
+{"abstract_id": "25200354", "label": "results", "text": "In arms A , B , and C , rates of early treatment discontinuation were @ % , @ % , and @ % ; of discontinuation due to an AE , @ % , @ % , and @ % ; and of AEs requiring dose modification , @ % , @ % , and @ % , respectively .", "sentence_id": 8}
+{"abstract_id": "25200354", "label": "conclusions", "text": "In Chinese patients with HBeAg-positive chronic hepatitis B , PEG-IFN alfa-@b @ g/kg/wk for @ weeks is more efficacious compared with @ and @ g/kg/wk for @ weeks .", "sentence_id": 9}
+{"abstract_id": "24582868", "label": "objective", "text": "To evaluate the impact of contact lens ( CL ) - induced corneal swelling on the optical quality of the eye by means of the double-pass technique .", "sentence_id": 0}
+{"abstract_id": "24582868", "label": "methods", "text": "Measurements of @ healthy subjects were obtained in @ visits over @ week , at baseline and after sleeping with @ different CLs of +@ D , +@ D , +@ D and +@ D ( Acuvue@ ) , randomly fitted on @ different days .", "sentence_id": 1}
+{"abstract_id": "24582868", "label": "methods", "text": "The control eye wore no CL .", "sentence_id": 2}
+{"abstract_id": "24582868", "label": "methods", "text": "Corneal pachymetry and optical quality of the eye ( OQAS , Visiometrics ) were measured once at baseline and at three interval times in the follow-up visits : immediately after CL removal , and @ and @ h after CL removal .", "sentence_id": 3}
+{"abstract_id": "24582868", "label": "methods", "text": "Optical quality was evaluated by means of the Strehl ratio and OQAS values at @ % , @ % and @ % contrasts .", "sentence_id": 4}
+{"abstract_id": "24582868", "label": "methods", "text": "Intraocular scattering was evaluated with the objective scatter index ( OSI ) .", "sentence_id": 5}
+{"abstract_id": "24582868", "label": "results", "text": "Mean overnight swelling was @ @ % in CL-eyes versus @ @ % in control eyes ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24582868", "label": "results", "text": "Corneal swelling was maximal immediately after CL removal and decreased with time ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24582868", "label": "results", "text": "A significant worsening in all optical quality parameters and a significant increase of the OSI were found in eyes with corneal swelling ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24582868", "label": "results", "text": "Two hours after CL removal there were no statistically significant differences ( p > @ ) between CL-eyes and control eyes in any of the measured parameters .", "sentence_id": 9}
+{"abstract_id": "24582868", "label": "conclusions", "text": "Corneal swelling has a significant impact on the optical quality of the eye and on intraocular scattering as assessed with the double-pass technique .", "sentence_id": 10}
+{"abstract_id": "24983307", "label": "background", "text": "Everolimus and cyclosporine A ( CsA ) exhibit synergistic immunosuppressive activity when used in combination .", "sentence_id": 0}
+{"abstract_id": "24983307", "label": "background", "text": "We examined the safety and efficacy of the use of everolimus with a cyclosporine-sparing strategy in de novo renal transplant recipients .", "sentence_id": 1}
+{"abstract_id": "24983307", "label": "methods", "text": "A comparative , parallel , randomized , open-label @-year study has been performed in @ patients from five transplant centers to compare the efficacy and tolerability of everolimus and reduced exposure CsA ( the investigational group ) or enteric-coated mycophenolate sodium and standard-exposure CsA ( the control group ) in combination with basiliximab and steroids .", "sentence_id": 2}
+{"abstract_id": "24983307", "label": "methods", "text": "The eligible subjects were randomly assigned at @ month after transplantation .", "sentence_id": 3}
+{"abstract_id": "24983307", "label": "methods", "text": "Efficacy failure ( biopsy-proven acute rejection , death , graft loss , or loss to follow-up ) , safety , and renal function were evaluated .", "sentence_id": 4}
+{"abstract_id": "24983307", "label": "results", "text": "One graft loss has been reported in the control group and no patient death were reported in either group .", "sentence_id": 5}
+{"abstract_id": "24983307", "label": "results", "text": "The incidence of biopsy-proven acute rejection until @ months after transplantation of the investigational group was @ % , compared to @ % of the control group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24983307", "label": "results", "text": "The mean estimated glomerular filtration rates of the investigational group at @ months after transplantation was significantly higher ( @ @ ml/min/@ @ m ( @ ) ) than that of the control group ( @ @ ml/min/@ @ m ( @ ) ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24983307", "label": "results", "text": "There was no significant difference ( P > @ ) in the incidence of discontinuations and serious adverse events between the groups .", "sentence_id": 8}
+{"abstract_id": "24983307", "label": "conclusions", "text": "The results of this study provide the evidences that ( @ ) the calcineurin inhibitor ( CNI ) minimization by the introduction of everolimus after @-month posttransplantation keeps the incidences of acute rejection and additional risks as low as the conventional immunosuppression ; ( @ ) it allows minimizing CNI exposure , consequently reducing CNI nephrotoxicity and preserving renal function .", "sentence_id": 9}
+{"abstract_id": "24473249", "label": "objective", "text": "The purpose of this randomized controlled study was to examine and compare the immediate and retention effects of speed-dependent treadmill training ( SDTT ) and rhythmic auditory-cued ( RAC ) overground walking on gait function and fall risk in individuals with Parkinson 's disease ( PD ) .", "sentence_id": 0}
+{"abstract_id": "24473249", "label": "methods", "text": "Twenty participants ( mean age @ yrs ) with idiopathic PD were randomized into either SDTT ( n = @ ) or RAC ( n = @ ) progressive , interval-based locomotor training protocols .", "sentence_id": 1}
+{"abstract_id": "24473249", "label": "methods", "text": "Immediate and retention training effects on gait function and fall risk were measured by comfortable and fast gait speed ( CGS , FGS ) , @-Minute Walk Test ( @MWT ) , and Functional Gait Assessment ( FGA ) .", "sentence_id": 2}
+{"abstract_id": "24473249", "label": "results", "text": "Immediate within-group training effects revealed significant gains in CGS , @MWT , and FGA for the RAC group , and in FGS , @-MinuteWalk Test , and FGA for the SDTT group .", "sentence_id": 3}
+{"abstract_id": "24473249", "label": "results", "text": "Retention effects were found at @-month follow-up for all gait measures in the RAC group , and for FGS and FGA in the SDTT group .", "sentence_id": 4}
+{"abstract_id": "24473249", "label": "results", "text": "No statistically significant differences in immediate or retention training effects on gait measures were found between groups .", "sentence_id": 5}
+{"abstract_id": "24473249", "label": "conclusions", "text": "Externally-cued locomotor training with progressive and interval-based speed challenges , either with RAC overground or on a treadmill , produced significant improvements in walking speed , endurance , and dynamic balance during walking .", "sentence_id": 6}
+{"abstract_id": "24226808", "label": "background", "text": "High-sensitivity troponin-I ( hs-TnI ) measurement improves risk assessment for cardiovascular events in many clinical settings , but the added value in atrial fibrillation patients has not been described .", "sentence_id": 0}
+{"abstract_id": "24226808", "label": "results", "text": "At randomization , hs-TnI was analyzed in @ @ atrial fibrillation patients in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation ( ARISTOTLE ) trial comparing apixaban with warfarin .", "sentence_id": 1}
+{"abstract_id": "24226808", "label": "results", "text": "The associations between hs-TnI concentrations and clinical outcomes were evaluated by using adjusted Cox analysis .", "sentence_id": 2}
+{"abstract_id": "24226808", "label": "results", "text": "The hs-TnI assay detected troponin ( @ ng/L ) in @ % patients , @ % had levels > @ , @ % had levels > @ , and @ % had levels @ ng/L ( the @th percentile in healthy individuals ) .", "sentence_id": 3}
+{"abstract_id": "24226808", "label": "results", "text": "During a median of @ years follow-up , annual rates of stroke or systemic embolism ranged from @ % in the lowest hs-TnI quartile to @ % in the highest quartile ( > @ ng/L ) .", "sentence_id": 4}
+{"abstract_id": "24226808", "label": "results", "text": "In multivariable analysis , hs-TnI was significantly associated with stroke or systemic embolism , adjusted hazard ratio @ ( @-@ @ ) , P = @ .", "sentence_id": 5}
+{"abstract_id": "24226808", "label": "results", "text": "hs-TnI was also significantly associated with cardiac death ; annual rates ranged from @ % to @ % , hazard ratio @ ( @-@ @ ) , P < @ , in the corresponding groups , and for major bleeding hazard ratio @ ( @-@ @ ) , P = @ .", "sentence_id": 6}
+{"abstract_id": "24226808", "label": "results", "text": "Adding hs-TnI levels to the CHA@DS@VASc score improved c-statistics from @ to @ for stroke or systemic embolism , and from @ to @ for cardiac death .", "sentence_id": 7}
+{"abstract_id": "24226808", "label": "results", "text": "There were no significant interactions with study treatment .", "sentence_id": 8}
+{"abstract_id": "24226808", "label": "conclusions", "text": "Troponin-I is detected in @ % and elevated in @ % of atrial fibrillation patients .", "sentence_id": 9}
+{"abstract_id": "24226808", "label": "conclusions", "text": "The hs-TnI level is independently associated with a raised risk of stroke , cardiac death , and major bleeding and improves risk stratification beyond the CHA@DS@VASc score .", "sentence_id": 10}
+{"abstract_id": "24226808", "label": "conclusions", "text": "The benefits of apixaban in comparison with warfarin are consistent regardless of hs-TnI levels .", "sentence_id": 11}
+{"abstract_id": "24796381", "label": "background", "text": "Heavy drinking among individuals with HIV is associated with major health concerns ( liver disease , medication nonadherence , immune functioning ) , but little is known about cognitive-motivational factors involved in alcohol consumption in this population , particularly reasons for limiting drinking .", "sentence_id": 0}
+{"abstract_id": "24796381", "label": "methods", "text": "Urban HIV primary care patients ( N = @ ; @ % male ; @ % African American or Hispanic ) in a randomized trial of brief drinking-reduction interventions reported on reasons for limiting drinking , alcohol consumption , and alcohol dependence symptoms prior to intervention .", "sentence_id": 1}
+{"abstract_id": "24796381", "label": "results", "text": "Exploratory factor analysis indicated @ main domains of reasons for limiting drinking : social reasons ( e.g. , responsibility to family ) , lifestyle reasons ( e.g. , religious/moral reasons ) , and impairment concerns ( e.g. , hangovers ) .", "sentence_id": 2}
+{"abstract_id": "24796381", "label": "results", "text": "These factors evidenced good internal consistency ( s = @ to @ ) .", "sentence_id": 3}
+{"abstract_id": "24796381", "label": "results", "text": "Higher scores on social reasons for limiting drinking were associated with lower typical quantity , maximum quantity , and binge frequency ( ps < @ ) , and higher scores on lifestyle reasons were associated with lower maximum quantity , binge frequency , and intoxication frequency ( ps < @ ) .", "sentence_id": 4}
+{"abstract_id": "24796381", "label": "results", "text": "In contrast , higher scores on impairment concerns were associated with more frequent drinking and intoxication , and higher risk of alcohol dependence ( ps < @ ) , likely because dependent drinkers are more familiar with alcohol-induced impairment .", "sentence_id": 5}
+{"abstract_id": "24796381", "label": "conclusions", "text": "The current study is the first to explore reasons for limiting drinking among individuals with HIV and how these reasons relate to alcohol involvement .", "sentence_id": 6}
+{"abstract_id": "24796381", "label": "conclusions", "text": "This study yields a scale that can be used to assess reasons for limiting drinking among HIV-positive drinkers and provides information that can be used to enhance interventions with this population .", "sentence_id": 7}
+{"abstract_id": "24796381", "label": "conclusions", "text": "Discussing social and lifestyle reasons for limiting drinking among less extreme drinkers may support and validate these patients ' efforts to limit engagement in heavy drinking ; discussion of impairment reasons for limiting drinking may be a way to engage dependent drinkers in efforts to decrease their alcohol consumption .", "sentence_id": 8}
+{"abstract_id": "24273930", "label": "background", "text": "Advanced type @ diabetes mellitus ( T@DM ) needing insulin therapy is common .", "sentence_id": 0}
+{"abstract_id": "24273930", "label": "background", "text": "Most conventional anti-hyperglycemic drugs have limited efficacies and significant side effects , so that better anti-hyperglycemic agents are needed .", "sentence_id": 1}
+{"abstract_id": "24273930", "label": "background", "text": "Urtica dioica L. ( nettle ) leaves have insulin secretagogue , PPARgamma agonistic , and alpha-glucosidase inhibitory effects .", "sentence_id": 2}
+{"abstract_id": "24273930", "label": "background", "text": "Moreover , nettle leaves are used in traditional medicine as an anti-hyperglycemic agent to treat diabetes mellitus .", "sentence_id": 3}
+{"abstract_id": "24273930", "label": "background", "text": "Thus , efficacy and safety of nettle in the treatment of patients with advanced type @ diabetes mellitus needing insulin were studied .", "sentence_id": 4}
+{"abstract_id": "24273930", "label": "methods", "text": "In this randomized double-blind placebo-controlled clinical trial , we evaluated the effects of taking nettle leaf extract ( one @ mg capsule every @ hours for @ months ) combined with the conventional oral anti-hyperglycemic drugs on the blood levels of fasting glucose , postprandial glucose , glycosylated hemoglobin ( HbA@c ) , creatinine and liver enzymes SGOT and SGPT , and systolic and diastolic blood pressures in @ patients and compared with the placebo group ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24273930", "label": "results", "text": "At the endpoint , the extract lowered the blood levels of fasting glucose , @ hours postprandial glucose , and HbA@c significantly ( p < @ , p = @ , and p = @ , respectively ) without any significant effects on the other parameters ( p > @ ) compared with placebo .", "sentence_id": 6}
+{"abstract_id": "24273930", "label": "conclusions", "text": "Nettle may safely improve glycemic control in type @ diabetic patients needing insulin therapy .", "sentence_id": 7}
+{"abstract_id": "25128002", "label": "background", "text": "In women with mixed urinary incontinence , pelvic floor muscle training and solifenacin is the recommended conservative treatment , while electroacupuncture is a safe , economical and effective option .", "sentence_id": 0}
+{"abstract_id": "25128002", "label": "methods", "text": "In this prospective , multi-center , randomized controlled trial , five hundred women with mixed urinary incontinence , from @ centers will be randomized to receive either electroacupuncture or pelvic floor muscle training plus solifenacin .", "sentence_id": 1}
+{"abstract_id": "25128002", "label": "methods", "text": "Women in the acupuncture group will receive electroacupuncture for @ sessions per week , over @ weeks , while women in the control group will receive pelvic floor muscle training plus solifenacin ( @ mg once daily ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25128002", "label": "methods", "text": "The primary outcome measure is the proportion of change in @-hour incontinence episode frequency from baseline to week @ .", "sentence_id": 3}
+{"abstract_id": "25128002", "label": "methods", "text": "The secondary outcome measures include eleven items , including proportion of participants with @ % decrease in average @-h incontinence episode frequency , change from baseline in the amount of urine leakage and proportion of change from baseline in @-h incontinence episode frequency in week @-@ , and so forth .", "sentence_id": 4}
+{"abstract_id": "25128002", "label": "methods", "text": "Statistical analysis will include covariance analysis , nonparametric tests and t tests .", "sentence_id": 5}
+{"abstract_id": "25128002", "label": "conclusions", "text": "The objective of this trial is to compare the efficacy and safety of electroacupuncture versus pelvic floor muscle training plus solifenacin in women with moderate and severe mixed urinary incontinence .", "sentence_id": 6}
+{"abstract_id": "25376735", "label": "background", "text": "In addition to their effects on bone health , high doses of cholecalciferol may have beneficial non-classic effects including the reduction of incidence of type @ diabetes mellitus , cardiovascular disease , and cancer .", "sentence_id": 0}
+{"abstract_id": "25376735", "label": "background", "text": "These pleiotropic effects have been documented in observational and experimental studies or in small intervention trials .", "sentence_id": 1}
+{"abstract_id": "25376735", "label": "background", "text": "Vitamin D insufficiency is a frequent finding in renal transplant recipients ( RTRs ) , and this population is at risk of the previously cited complications .", "sentence_id": 2}
+{"abstract_id": "25376735", "label": "methods", "text": "The VITALE study is a prospective , multicentre , double-blind , randomized , controlled trial with two parallel groups that will include a total of @ RTRs .", "sentence_id": 3}
+{"abstract_id": "25376735", "label": "methods", "text": "RTRs with vitamin D insufficiency , defined as circulating @-hydroxyvitamin D levels of less than @ ng/ml ( or @ nmol/l ) , will be randomized between @ and @ months after transplantation to blinded groups to receive vitamin D@ ( cholecalciferol ) either at high or low dose ( respectively , @,@ UI or @,@ UI every @ weeks for @ months then monthly for @ months ) with a follow-up of @ years .", "sentence_id": 4}
+{"abstract_id": "25376735", "label": "methods", "text": "The primary objective of the study is to evaluate the benefit/risk ratio of high-dose versus low-dose cholecalciferol on a composite endpoint consisting of de novo diabetes mellitus ; major cardiovascular events ; de novo cancer ; and patient death .", "sentence_id": 5}
+{"abstract_id": "25376735", "label": "methods", "text": "Secondary endpoints will include blood pressure ( BP ) control ; echocardiography findings ; the incidences of infection and acute rejection episodes ; renal allograft function using estimated glomerular filtration rate ; proteinuria ; graft survival ; bone mineral density ; the incidence of fractures ; and biological relevant parameters of mineral metabolism .", "sentence_id": 6}
+{"abstract_id": "25376735", "label": "conclusions", "text": "We previously reported that the intensive cholecalciferol treatment ( @ @ IU every @ weeks for @ months ) was safe in RTR .", "sentence_id": 7}
+{"abstract_id": "25376735", "label": "conclusions", "text": "Using a pharmacokinetic approach , we showed that cholecalciferol @,@ IU monthly should maintain serum @-hydroxyvitamin D at above @ ng/ml but below @ ng/ml after renal transplantation .", "sentence_id": 8}
+{"abstract_id": "25376735", "label": "conclusions", "text": "Taken together , these results are reassuring regarding the safety of the cholecalciferol doses that will be used in the VITALE study .", "sentence_id": 9}
+{"abstract_id": "25376735", "label": "conclusions", "text": "Analysis of data collected during the VITALE study will demonstrate whether high or low-dose cholecalciferol is beneficial in RTRs with vitamin D insufficiency .", "sentence_id": 10}
+{"abstract_id": "25162362", "label": "objective", "text": "The aim of the study was to evaluate the effectiveness and safety of @ different polyethylene glycol ( PEG ) doses for the maintenance treatment of functional constipation in children .", "sentence_id": 0}
+{"abstract_id": "25162362", "label": "methods", "text": "Children with functional constipation according to the Rome III criteria were randomly assigned to receive PEG @ at a dose of either @ g/kg ( high-dose group ; n = @ ) or @ g/kg ( low-dose group ; n = @ ) for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25162362", "label": "methods", "text": "Adjustment of the therapy was recommended in the event of < @ bowel movements ( BM ) per week or @ BM per day .", "sentence_id": 2}
+{"abstract_id": "25162362", "label": "methods", "text": "The primary outcome measure was treatment success , defined as @ BM per week with no fecal soiling during the last week of the intervention .", "sentence_id": 3}
+{"abstract_id": "25162362", "label": "results", "text": "A total of @ of @ randomized children , with a mean age of @ years , completed the study .", "sentence_id": 4}
+{"abstract_id": "25162362", "label": "results", "text": "In the analysis based on allocated treatment , treatment success was similar in both groups ( relative risk @ , @ % confidence interval @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25162362", "label": "results", "text": "Compared with the high-dose PEG group , the low-dose PEG group had an increased need for therapy adjustment of borderline significance ( relative risk @ , @ % confidence interval @-@ @ ) , an increased risk of painful defecation , a lower number of stools per week , and lower parental satisfaction .", "sentence_id": 6}
+{"abstract_id": "25162362", "label": "results", "text": "Adverse events were similar in both groups .", "sentence_id": 7}
+{"abstract_id": "25162362", "label": "conclusions", "text": "To achieve treatment success , both tested doses of PEG were equally safe and effective in the treatment of children with functional constipation .", "sentence_id": 8}
+{"abstract_id": "24310521", "label": "objective", "text": "We sought to assess the prognostic role of collaterals in a large population of patients presenting with an acute coronary syndrome ( ACS ) .", "sentence_id": 0}
+{"abstract_id": "24310521", "label": "methods", "text": "The coronary collateral circulation was assessed by an independent angiographic core laboratory using the Rentrop Score in patients enrolled in the randomised Acute Catheterization and Urgent Intervention Triage Strategy trial .", "sentence_id": 1}
+{"abstract_id": "24310521", "label": "results", "text": "The cohort comprised @ patients with moderate to high risk ACS .", "sentence_id": 2}
+{"abstract_id": "24310521", "label": "results", "text": "A total of @ patients ( @ % ) had visible collaterals while @ patients ( @ % ) had no collaterals .", "sentence_id": 3}
+{"abstract_id": "24310521", "label": "results", "text": "After multivariable adjustment , there were no differences in clinical outcomes at @ year between the groups , including major adverse cardiac events ( MACE ) ( HR @ ( @ % CI @ to @ ) , p = @ ) , mortality ( HR @ ( @ to @ ) , p = @ ) , myocardial infarction ( MI ) ( HR @ ( @ to @ ) , p = @ ) and unplanned target vessel revascularisation ( TVR ) ( HR @ ( @ to @ ) , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24310521", "label": "results", "text": "Similarly , in the subgroup of patients undergoing percutaneous coronary intervention ( PCI ) , the adjusted HR for major adverse cardiac events was @ ( @ to @ ) , p = @ ; @ ( @ to @ ) , p = @ for mortality ; and @ ( @ to @ ) , p = @ for MI .", "sentence_id": 5}
+{"abstract_id": "24310521", "label": "results", "text": "The risk of unplanned TVR was increased ( HR @ ( @ to @ ) , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24310521", "label": "conclusions", "text": "In contrast to other studies , this large core laboratory-based analysis does not confirm a beneficial role of visible coronary collateral vessels on clinical outcomes in patients with ACS ; the presence of collaterals was even associated with increased mortality in the unadjusted analysis .", "sentence_id": 7}
+{"abstract_id": "24310521", "label": "conclusions", "text": "Collaterals were associated with a higher risk of TVR in patients undergoing PCI , a finding that may not have been fully corrected given confounders and clinical differences between the groups .", "sentence_id": 8}
+{"abstract_id": "24668250", "label": "objective", "text": "The goal of this work was to evaluate the long-term efficacy of two dose-fractionation schedules for radiotherapy of calcaneodynia .", "sentence_id": 0}
+{"abstract_id": "24668250", "label": "methods", "text": "Between February @ and February @ , @ evaluable patients were recruited for this prospective trial .", "sentence_id": 1}
+{"abstract_id": "24668250", "label": "methods", "text": "All patients received orthovoltage radiotherapy .", "sentence_id": 2}
+{"abstract_id": "24668250", "label": "methods", "text": "One course consisted of @ fractions/@ weeks .", "sentence_id": 3}
+{"abstract_id": "24668250", "label": "methods", "text": "In case of insufficient remission of pain after @ weeks a second series was performed .", "sentence_id": 4}
+{"abstract_id": "24668250", "label": "methods", "text": "Patients were randomly assigned to receive either single doses of @ or @ Gy .", "sentence_id": 5}
+{"abstract_id": "24668250", "label": "methods", "text": "Endpoint was pain reduction .", "sentence_id": 6}
+{"abstract_id": "24668250", "label": "methods", "text": "Pain was measured before , right after ( early response ) , @ weeks ( delayed response ) , and approximately @ years after radiotherapy ( long-term response ) with a questionnaire-based visual analogue scale ( VAS ) and a comprehensive pain score ( CPS ) .", "sentence_id": 7}
+{"abstract_id": "24668250", "label": "results", "text": "The median follow-up was @ months ( range @-@ months ) .", "sentence_id": 8}
+{"abstract_id": "24668250", "label": "results", "text": "The overall early , delayed , and long-term response rates for all patients were @ , @ , and @ % .", "sentence_id": 9}
+{"abstract_id": "24668250", "label": "results", "text": "The mean VAS values before treatment , for early , delayed , and long-term response for the @ and @ Gy groups were @ and @ ( p = @ ) , @ and @ ( p = @ ) , @ and @ ( p = @ ) , and @ and @ ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24668250", "label": "results", "text": "The mean CPS values before treatment , for early , delayed , and log-term response were @ and @ ( p = @ ) , @ and @ ( p = @ ) , @ and @ ( p = @ ) , and @ and @ ( p = @ ) , respectively .", "sentence_id": 11}
+{"abstract_id": "24668250", "label": "results", "text": "No significant differences in long-term response quality between the two arms were found ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24668250", "label": "conclusions", "text": "Radiotherapy is a very effective treatment for the management of benign calcaneodynia .", "sentence_id": 13}
+{"abstract_id": "24668250", "label": "conclusions", "text": "For radiation protection reasons , the dose for a RT series should not exceed @ Gy .", "sentence_id": 14}
+{"abstract_id": "25650142", "label": "objective", "text": "In the present study , we applied two incisionless suture techniques for otoplasty : Haytoglu et al. 's modification of incisionless otoplasty technique and Fritsch 's incisionless otoplasty technique for correction of prominent ears .", "sentence_id": 0}
+{"abstract_id": "25650142", "label": "methods", "text": "In this prospective study , @ patients with prominent ears were included in the study .", "sentence_id": 1}
+{"abstract_id": "25650142", "label": "methods", "text": "In Group @ , @ ears of @ patients ( @ bilateral and @ unilateral ) were operated with Haytoglu et al. 's modification of incisionless otoplasty technique .", "sentence_id": 2}
+{"abstract_id": "25650142", "label": "methods", "text": "In Group @ , @ ears of @ patients ( @ bilateral and @ unilateral ) were operated with Fritsch 's incisionless otoplasty technique .", "sentence_id": 3}
+{"abstract_id": "25650142", "label": "methods", "text": "For comparison of two methods , auriculocephalic distances were measured at three levels which were level @ ( the most superior point of the auricle ) , level @ ( the midpoint of the auricle ) and level @ ( level of the lobule ) pre-operatively ( preop ) ; and measurements were repeated at the end of the surgery ( PO ( @-day ) ) , @st month ( PO ( @-Mo ) ) and @th month ( PO ( @-Mo ) ) after the surgery , in both groups .", "sentence_id": 4}
+{"abstract_id": "25650142", "label": "methods", "text": "Patient satisfaction was evaluated using a visual analog scale ( VAS ) .", "sentence_id": 5}
+{"abstract_id": "25650142", "label": "methods", "text": "Moreover , Global Aesthetic Improvement Scale ( GAIS ) was rated by an independent , non-participating plastic surgeon at @ months after the surgery .", "sentence_id": 6}
+{"abstract_id": "25650142", "label": "results", "text": "Operation time was @ min in Group @ ( Haytoglu et al. 's ) and @ min in Group @ ( Fritsch ) .", "sentence_id": 7}
+{"abstract_id": "25650142", "label": "results", "text": "Hematoma , infection , bleeding , keloid scar formation , sharp edges or irregularities of the cartilage were not observed in any group .", "sentence_id": 8}
+{"abstract_id": "25650142", "label": "results", "text": "Suture extrusion was detected in @ % of Group @ and @ % of Group @ .", "sentence_id": 9}
+{"abstract_id": "25650142", "label": "results", "text": "No statistically significant difference was observed between auriculocephalic distances at levels @-@ of groups at preop , PO ( @-day ) , PO ( @-Mo ) and PO ( @-Mo ) separately .", "sentence_id": 10}
+{"abstract_id": "25650142", "label": "results", "text": "Similarly , difference in auriculocephalic distances ( preop values-PO ( @-Mo ) values ) was not detected as statistically significant in Groups @ and @ at three levels .", "sentence_id": 11}
+{"abstract_id": "25650142", "label": "results", "text": "In both techniques , No statistically significant difference was observed in patient satisfaction at @th months after the operation which was measured using Visual Analogue Scale ( VAS ) on @ to @ scales .", "sentence_id": 12}
+{"abstract_id": "25650142", "label": "results", "text": "According to GAIS , the patients were rated as @ % `` improved '' and @ % `` no change '' in Group @ ; as @ % `` improved '' and @ % `` no change '' in Group @ .", "sentence_id": 13}
+{"abstract_id": "25650142", "label": "conclusions", "text": "Due to the similar results , Haytoglu et al. 's and Fritsch 's incisionless otoplasty techniques are good options in the treatment of prominent ears , especially in pediatric patients with isolated inadequate development of antihelical ridge , and with soft auricular cartilage .", "sentence_id": 14}
+{"abstract_id": "26152838", "label": "objective", "text": "Determine if oral treatment with a vasoconstrictor decreases the blood to middle ear exchange rate of the perfusion-limited gas , nitrous oxide ( N@O ) .", "sentence_id": 0}
+{"abstract_id": "26152838", "label": "methods", "text": "Randomized , double-blind , crossover study .", "sentence_id": 1}
+{"abstract_id": "26152838", "label": "methods", "text": "Ten adult subjects with and @ without past middle ear disease completed paired experimental sessions , identical except for oral treatment with either pseudoephedrine hydrochloride or lactose placebo .", "sentence_id": 2}
+{"abstract_id": "26152838", "label": "methods", "text": "At each session , subjects were fitted with a nonrebreathing mask and breathed room air for @ minutes ( acclimation period ) , @ % N@O :@ % O@ for @ minutes ( experimental period ) , and @ % O@ for @ minutes ( recovery period ) .", "sentence_id": 3}
+{"abstract_id": "26152838", "label": "methods", "text": "Throughout , heart rate , blood pressure , and O@ saturation were monitored , and bilateral middle ear pressures were recorded by tympanometry every minute .", "sentence_id": 4}
+{"abstract_id": "26152838", "label": "methods", "text": "The primary outcome was the slope of the middle ear pressure-time function for the experimental period , which estimates the volume N@O exchange rate .", "sentence_id": 5}
+{"abstract_id": "26152838", "label": "methods", "text": "Using repeated measures analysis of variance , the effects of group ( disease history ) , treatment ( active vs. placebo ) , and period ( @ vs. @ ) on the recorded vital signs , and of group , treatment , and ear ( left/right ) on the middle ear pressure-time slope were evaluated for statistical significance .", "sentence_id": 6}
+{"abstract_id": "26152838", "label": "results", "text": "Statistically significant effects of period on O@ saturation ( period @ > period @ ) and of treatment on heart rate ( active > placebo ) were documented .", "sentence_id": 7}
+{"abstract_id": "26152838", "label": "results", "text": "Only treatment was statistically significant for the middle ear pressure-time slope , with a shallower slope characterizing the active treatment session .", "sentence_id": 8}
+{"abstract_id": "26152838", "label": "conclusions", "text": "The volume exchange rate across the middle ear mucosa of perfusion-limited gases can be modulated pharmacologically .", "sentence_id": 9}
+{"abstract_id": "26152838", "label": "conclusions", "text": "Theoretically , similar drugs can be used to reduce the requisite eustachian tube opening efficiency for adequate middle ear pressure regulation .", "sentence_id": 10}
+{"abstract_id": "24393548", "label": "objective", "text": "Pain attitudes and beliefs are hypothesized to influence pain and adjustment to pain .", "sentence_id": 0}
+{"abstract_id": "24393548", "label": "objective", "text": "Valid and reliable measures of these beliefs are necessary to test their hypothesized associations with outcomes .", "sentence_id": 1}
+{"abstract_id": "24393548", "label": "objective", "text": "The Pediatric version of the Survey of Pain Attitudes ( Peds-SOPA ) is a new measure with limited evidence regarding its psychometric properties .", "sentence_id": 2}
+{"abstract_id": "24393548", "label": "objective", "text": "This study sought to : @ ) evaluate the predictive validity , reliability , and factor structure of the Peds-SOPA ; and @ ) determine if there are sex - or age-related differences in children 's attitudes toward pain .", "sentence_id": 3}
+{"abstract_id": "24393548", "label": "methods", "text": "Longitudinal study .", "sentence_id": 4}
+{"abstract_id": "24393548", "label": "methods", "text": "Five hundred and sixty-one schoolchildren between @ and @ years old participated in this study .", "sentence_id": 5}
+{"abstract_id": "24393548", "label": "results", "text": "Factor analyses supported the seven-factor structure described by the original authors .", "sentence_id": 6}
+{"abstract_id": "24393548", "label": "results", "text": "The Peds-SOPA showed acceptable reliability with Cronbach alpha values ranging from @ to @ .", "sentence_id": 7}
+{"abstract_id": "24393548", "label": "results", "text": "The Peds-SOPA scales also demonstrated prospective predictive validity via their associations with pain intensity , and pain status at @-year follow-up .", "sentence_id": 8}
+{"abstract_id": "24393548", "label": "results", "text": "The findings also showed some few sex - and age-specific differences in the Peds-SOPA scores .", "sentence_id": 9}
+{"abstract_id": "24393548", "label": "conclusions", "text": "The current findings provide additional support for the reliability and validity of the Peds-SOPA , and suggest that children 's pain attitudes and beliefs might be important intervention targets in pain treatment .", "sentence_id": 10}
+{"abstract_id": "25993609", "label": "background", "text": "This is the third study in a Phase @ program evaluating onabotulinumtoxinA treatment of crow 's feet lines ( CFL ) .", "sentence_id": 0}
+{"abstract_id": "25993609", "label": "objective", "text": "To assess the efficacy and safety of repeated onabotulinumtoxinA treatments of CFL alone or with glabellar lines ( GL ) in subjects with moderate-to-severe CFL and GL ( maximum smile ) .", "sentence_id": 1}
+{"abstract_id": "25993609", "label": "methods", "text": "This @-month extension of a @-month study randomized subjects who originally received onabotulinumtoxinA @ U ( CFL only ; n = @ ) or @ U ( @ U for CFL + @ U for GL ; n = @ ) to retreatment with the same dose .", "sentence_id": 2}
+{"abstract_id": "25993609", "label": "methods", "text": "Placebo-treated subjects were rerandomized to onabotulinumtoxinA @ U ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25993609", "label": "methods", "text": "Primary efficacy end point ( Day @ ) was the proportion of subjects who achieved a CFL severity rating of none or mild ( maximum smile ) on the investigator-assessed Facial Wrinkle Scale ( FWS ) .", "sentence_id": 4}
+{"abstract_id": "25993609", "label": "methods", "text": "Additional efficacy end points and adverse events were evaluated .", "sentence_id": 5}
+{"abstract_id": "25993609", "label": "results", "text": "Responder rates ( primary end point ) were significantly greater in onabotulinumtoxinA-treated groups ( @ U : @ % ; @ U : @ % ; placebo : @ % ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25993609", "label": "results", "text": "Improvements on most patient-reported outcomes ( PROs ) favored the @-U group over the @-U group .", "sentence_id": 7}
+{"abstract_id": "25993609", "label": "results", "text": "Adverse events did not differ among groups ; most were mild or moderate .", "sentence_id": 8}
+{"abstract_id": "25993609", "label": "conclusions", "text": "Repeated onabotulinumtoxinA treatments significantly reduce CFL severity based on FWS and PROs .", "sentence_id": 9}
+{"abstract_id": "25993609", "label": "conclusions", "text": "Adverse event profiles remain consistent with approved GL labeling .", "sentence_id": 10}
+{"abstract_id": "25831464", "label": "background", "text": "Few randomized clinical trials have investigated antiretroviral regimens in very advanced HIV-@-infected patients .", "sentence_id": 0}
+{"abstract_id": "25831464", "label": "background", "text": "The objective was to study the immune reconstitution in very immunosuppressed antiretroviral-naive , HIV-@-infected individuals by comparing an efavirenz-based regimen with @ ritonavir-boosted protease inhibitor regimens .", "sentence_id": 1}
+{"abstract_id": "25831464", "label": "methods", "text": "Randomized , controlled , open-label , multicenter clinical trial .", "sentence_id": 2}
+{"abstract_id": "25831464", "label": "methods", "text": "Eighty-nine HIV-@-infected antiretroviral-naive patients with < @ CD@ cells per cubic millimeter were randomly assigned in a @:@:@ ratio to efavirenz ( n = @ ) , atazanavir/ritonavir ( n = @ ) , or lopinavir/ritonavir ( n = @ ) combined with tenofovir plus emtricitabine .", "sentence_id": 3}
+{"abstract_id": "25831464", "label": "methods", "text": "The primary outcome was median increase in CD@ cell count at week @ .", "sentence_id": 4}
+{"abstract_id": "25831464", "label": "methods", "text": "Secondary end points were the proportion of patients with HIV-@ RNA < @ copies per milliliter , adverse events , disease progression , and death .", "sentence_id": 5}
+{"abstract_id": "25831464", "label": "results", "text": "In the on-treatment analysis , the median ( interquartile range ) increase in the CD@ count after @ weeks was +@ ( @-@ ) cells per microliter in the efavirenz arm , +@ ( @-@ ) cells per microliter in the ritonavir-boosted atazanavir arm , and +@ ( @-@ ) cells per microliter in the ritonavir-boosted lopinavir arm ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25831464", "label": "results", "text": "The percentage of patients achieving viral suppression was similar in all @ treatment arms at @ weeks -LCB- efavirenz , @ % -LSB- @ % confidence interval ( CI ) : @ to @ -RSB- ; atazanavir , @ % -LSB- @ % CI : @ to @ -RSB- ; and lopinavir , @ % -LSB- @ % CI : @ to @ -RSB- ; P = @ -RCB- .", "sentence_id": 7}
+{"abstract_id": "25831464", "label": "results", "text": "Bacterial translocation , inflammation , immune activation , and apoptotic markers , but not D-dimer , declined significantly and similarly in the @ treatment arms .", "sentence_id": 8}
+{"abstract_id": "25831464", "label": "results", "text": "Adverse events had a similar incidence in all @ antiretroviral regimens .", "sentence_id": 9}
+{"abstract_id": "25831464", "label": "results", "text": "No patients died .", "sentence_id": 10}
+{"abstract_id": "25831464", "label": "conclusions", "text": "The immune reconstitution induced by an efavirenz-based regimen in very advanced HIV-@-infected patients was similar to that induced by a ritonavir-boosted protease inhibitor-based regimen ( ClinicalTrials.gov registration number : NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "26156651", "label": "background", "text": "There is a major unmet need for effective treatments in patients with squamous cell carcinoma of the lung .", "sentence_id": 0}
+{"abstract_id": "26156651", "label": "background", "text": "LUX-Lung @ compared afatinib ( an irreversible ErbB family blocker ) with erlotinib ( a reversible EGFR tyrosine kinase inhibitor ) , as second-line treatment for patients with advanced squamous cell carcinoma of the lung .", "sentence_id": 1}
+{"abstract_id": "26156651", "label": "methods", "text": "We did this open-label , phase @ randomised controlled trial at @ cancer centres in @ countries worldwide .", "sentence_id": 2}
+{"abstract_id": "26156651", "label": "methods", "text": "We enrolled adults with stage IIIB or IV squamous cell carcinoma of the lung who had progressed after at least four cycles of platinum-based-chemotherapy .", "sentence_id": 3}
+{"abstract_id": "26156651", "label": "methods", "text": "Participants were randomly assigned ( @:@ ) to receive afatinib ( @ mg per day ) or erlotinib ( @ mg per day ) until disease progression .", "sentence_id": 4}
+{"abstract_id": "26156651", "label": "methods", "text": "The randomisation was done centrally with an interactive voice or web-based response system and stratified by ethnic origin ( eastern Asian vs non-eastern Asian ) .", "sentence_id": 5}
+{"abstract_id": "26156651", "label": "methods", "text": "Clinicians and patients were not masked to treatment allocation .", "sentence_id": 6}
+{"abstract_id": "26156651", "label": "methods", "text": "The primary endpoint was progression-free survival assessed by independent central review ( intention-to-treat population ) .", "sentence_id": 7}
+{"abstract_id": "26156651", "label": "methods", "text": "The key secondary endpoint was overall survival .", "sentence_id": 8}
+{"abstract_id": "26156651", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 9}
+{"abstract_id": "26156651", "label": "results", "text": "@ eligible patients were randomly assigned ( @ to afatinib , @ to erlotinib ) .", "sentence_id": 10}
+{"abstract_id": "26156651", "label": "results", "text": "Median follow-up at the time of the primary analysis of progression-free survival was @ months ( IQR @-@ ) , at which point enrolment was not complete .", "sentence_id": 11}
+{"abstract_id": "26156651", "label": "results", "text": "Progression free-survival at the primary analysis was significantly longer with afatinib than with erlotinib ( median @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; hazard ratio -LSB- HR -RSB- @ -LSB- @ % CI @-@ -RSB- , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "26156651", "label": "results", "text": "At the time of the primary analysis of overall survival ( median follow-up @ months -LSB- IQR @-@ -RSB- ) , overall survival was significantly greater in the afatinib group than in the erloinib group ( median @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; HR @ -LSB- @ % CI @-@ -RSB- , p = @ ) , as were progression-free survival ( median @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; HR @ -LSB- @ % CI @-@ -RSB- , p = @ ) and disease control ( @ -LSB- @ % -RSB- of @ patients vs @ -LSB- @ % -RSB- of @ ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "26156651", "label": "results", "text": "The proportion of patients with an objective response did not differ significantly between groups ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ; p = @ ) .", "sentence_id": 14}
+{"abstract_id": "26156651", "label": "results", "text": "Tumour shrinkage occurred in @ ( @ % ) of @ patients versus @ ( @ % ) of @ patients .", "sentence_id": 15}
+{"abstract_id": "26156651", "label": "results", "text": "Adverse event profiles were similar in each group : @ ( @ % ) of @ patients in the afatinib group versus @ ( @ % ) of @ in the erlotinib group had grade @ or higher adverse events .", "sentence_id": 16}
+{"abstract_id": "26156651", "label": "results", "text": "We recorded higher incidences of treatment-related grade @ diarrhoea with afatinib ( @ -LSB- @ % -RSB- vs nine -LSB- @ % -RSB- ) , of grade @ stomatitis with afatinib ( @ -LSB- @ % -RSB- vs none ) , and of grade @ rash or acne with erlotinib ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 17}
+{"abstract_id": "26156651", "label": "conclusions", "text": "The significant improvements in progression-free survival and overall survival with afatinib compared with erlotinib , along with a manageable safety profile and the convenience of oral administration suggest that afatinib could be an additional option for the treatment of patients with squamous cell carcinoma of the lung .", "sentence_id": 18}
+{"abstract_id": "24761456", "label": "objective", "text": "Physicians adopt evidence-based guidelines with variable consistency .", "sentence_id": 0}
+{"abstract_id": "24761456", "label": "objective", "text": "Narratives , or stories , offer a novel dissemination strategy for clinical recommendations .", "sentence_id": 1}
+{"abstract_id": "24761456", "label": "objective", "text": "The study objective was to compare whether evidence-based narrative versus traditional summary improved recall of opioid prescribing guidelines from the American College of Emergency Physicians ( ACEP ) .", "sentence_id": 2}
+{"abstract_id": "24761456", "label": "methods", "text": "This was a prospective , randomized controlled experiment to compare whether narrative versus summary promoted short-term recall of six themes contained in the ACEP opioid guideline .", "sentence_id": 3}
+{"abstract_id": "24761456", "label": "methods", "text": "The experiment was modeled after the free-recall test , an established technique in studies of memory .", "sentence_id": 4}
+{"abstract_id": "24761456", "label": "methods", "text": "At a regional conference , emergency physicians ( EPs ) were randomized to read either a summary of the guideline ( control ) or a narrative ( intervention ) .", "sentence_id": 5}
+{"abstract_id": "24761456", "label": "methods", "text": "The fictional narrative was constructed to match the summary in content and length .", "sentence_id": 6}
+{"abstract_id": "24761456", "label": "methods", "text": "One hour after reading the text , participants listed all content that they could recall .", "sentence_id": 7}
+{"abstract_id": "24761456", "label": "methods", "text": "Two reviewers independently scored the responses to assess recall of the six themes .", "sentence_id": 8}
+{"abstract_id": "24761456", "label": "methods", "text": "The primary outcome was the total number of themes recalled per participant .", "sentence_id": 9}
+{"abstract_id": "24761456", "label": "methods", "text": "Secondary outcomes included the proportion of responses in each study arm that recalled individual themes and the proportion of responses in each arm that contained falsely recalled or extraneous information .", "sentence_id": 10}
+{"abstract_id": "24761456", "label": "results", "text": "Ninety-five physicians were randomized .", "sentence_id": 11}
+{"abstract_id": "24761456", "label": "results", "text": "Eighty-two physicians completed the experiment , for a response rate of @ % .", "sentence_id": 12}
+{"abstract_id": "24761456", "label": "results", "text": "The mean of the total number of themes recalled per participant was @ in the narrative arm versus @ in the summary arm ( difference = @ , @ % confidence interval -LSB- CI -RSB- = @ to @ ) .", "sentence_id": 13}
+{"abstract_id": "24761456", "label": "results", "text": "For three themes , the proportion of responses that recalled the theme was significantly greater in the narrative arm compared to the summary arm , with the differences ranging from @ % to @ % .", "sentence_id": 14}
+{"abstract_id": "24761456", "label": "results", "text": "For one theme , recall was significantly greater in the summary arm .", "sentence_id": 15}
+{"abstract_id": "24761456", "label": "results", "text": "For two themes , there was no statistically significant difference in recall between the arms .", "sentence_id": 16}
+{"abstract_id": "24761456", "label": "results", "text": "In the summary arm , @ % of responses were found to contain falsely recalled or extraneous information versus @ % of responses in the narrative arm ( difference = @ % , @ % CI = @ % to @ % ) .", "sentence_id": 17}
+{"abstract_id": "24761456", "label": "conclusions", "text": "Physicians exposed to a narrative about opioid guidelines were more likely to recall guideline content at @ hour than those exposed to a summary of the guidelines .", "sentence_id": 18}
+{"abstract_id": "24761456", "label": "conclusions", "text": "Future studies should examine whether the incorporation of narratives in dissemination campaigns improves guideline adoption and changes clinical practice", "sentence_id": 19}
+{"abstract_id": "24237188", "label": "objective", "text": "Paullinia cupana ( guaran ) is an Amazonian plant that has been previously shown to be effective in treating chemotherapy-related fatigue ( CRF ) in patients with breast cancer .", "sentence_id": 0}
+{"abstract_id": "24237188", "label": "objective", "text": "We aimed to evaluate the efficacy of a purified dry extract of P. cupana ( PC-@ ) in patients with various solid tumors treated with chemotherapy .", "sentence_id": 1}
+{"abstract_id": "24237188", "label": "methods", "text": "We included @ patients with solid tumors who showed increases in their Brief Fatigue Inventory ( BFI ) questionnaire scores after @ week of systemic chemotherapy .", "sentence_id": 2}
+{"abstract_id": "24237188", "label": "methods", "text": "PC-@ was administered at @ mg by mouth two times per day ( PO bid ) , starting after @ week of chemotherapy , for @ weeks ( induction phase ) .", "sentence_id": 3}
+{"abstract_id": "24237188", "label": "methods", "text": "Patients who had an improvement in or stabilization of their BFI scores were randomized to receive either PC-@ at the same dose or placebo for the following @ weeks ( maintenance phase ) .", "sentence_id": 4}
+{"abstract_id": "24237188", "label": "results", "text": "After PC-@ treatment , the BFI fatigue scores improved or stabilized in @ out of the @ patients ( mean BFI score difference = @ ; @ % confidence interval : @-@ @ , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24237188", "label": "results", "text": "Three weeks after randomization ( @ patients on PC-@ and @ on placebo ) , we observed no significant differences in the BFI , Functional Assessment of Chronic Illness Therapy , Hospital Anxiety and Depression Scale , and Pittsburgh Sleep Quality Index scores between patients randomized to PC-@ versus placebo .", "sentence_id": 6}
+{"abstract_id": "24237188", "label": "conclusions", "text": "We conclude that the PC-@ extract may be effective for the treatment of CRF in patients with a variety of solid tumors .", "sentence_id": 7}
+{"abstract_id": "24237188", "label": "conclusions", "text": "A conditioning effect , which was observed in patients who had a beneficial effect of PC-@ on CRF , may explain the better than expected fatigue scores of the placebo-treated patients .", "sentence_id": 8}
+{"abstract_id": "24527503", "label": "background", "text": "A single session of left prefrontal rTMS has been shown to have analgesic effects , and to reduce post-operative morphine use .", "sentence_id": 0}
+{"abstract_id": "24527503", "label": "background", "text": "We sought to test these findings in a larger sample , and try and see if multiple sessions had additive analgesic benefit .", "sentence_id": 1}
+{"abstract_id": "24527503", "label": "methods", "text": "@ patients undergoing laparoscopic gastric bypass surgery received two sessions of @ Hz rTMS ( @ % of motor threshold ) over the left dorsolateral prefrontal cortex ( one immediately following surgery and one @ h later ) .", "sentence_id": 2}
+{"abstract_id": "24527503", "label": "methods", "text": "Participants were randomly assigned to receive @ sessions of real rTMS , @ sessions of sham , @ real then @ sham , or @ sham then @ real rTMS treatments .", "sentence_id": 3}
+{"abstract_id": "24527503", "label": "methods", "text": "Patients and study staff were blind to rTMS conditions .", "sentence_id": 4}
+{"abstract_id": "24527503", "label": "results", "text": "Unlike previous rTMS trials for post-operative pain , no differences emerged between groups with respect to total patient-controlled analgesia usage ( IV hydromorphone ) .", "sentence_id": 5}
+{"abstract_id": "24527503", "label": "results", "text": "However , despite no difference in IV analgesic usage , subjects that received @ real rTMS sessions rated both the affective and sensory dimensions of their pain significantly lower than those in the shamsham group at several time points during the post-surgical/post-rTMS period .", "sentence_id": 6}
+{"abstract_id": "24527503", "label": "conclusions", "text": "This study suggests that left prefrontal rTMS may produce significant analgesic effects in the perioperative setting .", "sentence_id": 7}
+{"abstract_id": "24527503", "label": "conclusions", "text": "However , further work is needed to understand this effect and attempt to make it clinically useful in light of the lack of effect on PCA hydromorphone use .", "sentence_id": 8}
+{"abstract_id": "25565482", "label": "objective", "text": "Increasing physical activity is an important public-health goal worldwide , but there are few published mediation analyses of physical-activity interventions in low-to-middle-income countries like South Africa undergoing a health transition involving markedly increased mortality from non-communicable diseases .", "sentence_id": 0}
+{"abstract_id": "25565482", "label": "objective", "text": "This article reports secondary analyses on the mediation of a theory-of-planned-behavior-based behavioral intervention that increased self-reported physical activity in a trial with @ men in Eastern Cape Province , South Africa .", "sentence_id": 1}
+{"abstract_id": "25565482", "label": "methods", "text": "Twenty-two matched-pairs of neighborhoods were randomly selected .", "sentence_id": 2}
+{"abstract_id": "25565482", "label": "methods", "text": "Within pairs , neighborhoods were randomized to a health-promotion intervention or an attention-matched control intervention with baseline , immediate-post , and @ - and @-month post-intervention assessments .", "sentence_id": 3}
+{"abstract_id": "25565482", "label": "methods", "text": "Theory-of-planned-behavior constructs measured immediately post-intervention were tested as potential mediators of the primary outcome , self-reported physical activity averaged over the @ - and @-month post-intervention assessments , using a product-of-coefficients approach in a generalized-estimating-equations framework .", "sentence_id": 4}
+{"abstract_id": "25565482", "label": "methods", "text": "Data were collected in @-@ .", "sentence_id": 5}
+{"abstract_id": "25565482", "label": "results", "text": "Attitude , subjective norm , self-efficacy , and intention were significant mediators of intervention-induced increases in self-reported physical activity .", "sentence_id": 6}
+{"abstract_id": "25565482", "label": "results", "text": "The descriptive norm , not affected by the intervention , was not a mediator , but predicted increased self-reported physical activity .", "sentence_id": 7}
+{"abstract_id": "25565482", "label": "conclusions", "text": "The results suggest that interventions targeting theory-of-planned-behavior constructs may contribute to efforts to increase physical activity to reduce the burden of non-communicable diseases among South African men .", "sentence_id": 8}
+{"abstract_id": "25790673", "label": "objective", "text": "To observe the intervention effect of nourishing Xin and Shen method ( NXSM ) on the cognitive function of mild cognitive impairment due to subcortical small vessel disease ( MCI-SSVD ) .", "sentence_id": 0}
+{"abstract_id": "25790673", "label": "methods", "text": "All @ MCI-SSVD patients came from Department of Traditional Chinese Medicine , Affiliated Union Hospital of Fujian Medical University from June @ to August @ .", "sentence_id": 1}
+{"abstract_id": "25790673", "label": "methods", "text": "They were randomly assigned to the treatment group ( @ cases ) and the control group ( @ cases ) .", "sentence_id": 2}
+{"abstract_id": "25790673", "label": "methods", "text": "Another @ volunteers were recruited as a healthy control group .", "sentence_id": 3}
+{"abstract_id": "25790673", "label": "methods", "text": "On the basis of targeting risk factors of blood vessels , MCI-SSVD patients were treated respectively with NXSM and donepezil hydrochloride , with the therapeutic course of @ weeks .", "sentence_id": 4}
+{"abstract_id": "25790673", "label": "methods", "text": "Neuropsychological scales -LSB- mini-mental state examination ( MMSE ) and Montreal cognitive assessment ( MoCA ) -RSB- , and Chinese medical dementia syndrome scales were performed in all subjects , and results were compared among groups or intra-group before and after treatment .", "sentence_id": 5}
+{"abstract_id": "25790673", "label": "results", "text": "MMSE and MoCA scores of the two treatment groups decreased more , when compared with those of the healthy control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25790673", "label": "results", "text": "In particular , MoCA score was significantly decreased ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25790673", "label": "results", "text": "MMSE and MoCA scores of the two treatment groups increased more after treatment than before treatment ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25790673", "label": "results", "text": "But there was no statistical difference in MMSE or MOCA score after treatment between the two groups ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25790673", "label": "results", "text": "Chinese medical dementia syndrome scales decreased more significantly in the treatment group , when compared with before treatment ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25790673", "label": "results", "text": "But there was no statistical difference in Chinese medical dementia syndrome scales in the control group between before and after treatment ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "25790673", "label": "results", "text": "Visual spatial and executive function scores or delayed recall scores of the two treatment groups increased more , when compared with the same group before treatment ( P < @ , P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25790673", "label": "conclusions", "text": "NXSM could effectively improve cognitive functions of MCI-SSVD .", "sentence_id": 13}
+{"abstract_id": "25675562", "label": "objective", "text": "To optimize the therapeutic programs for periarthritis of shoulder treated with acupuncture , moxibustion and kinetohterapy with orthogonal design method adopted .", "sentence_id": 0}
+{"abstract_id": "25675562", "label": "methods", "text": "The orthogonal design table of L@ ( @ ( @ ) ) hierarchical principle was used to randomly divide @ patients of periarthritis of shoulder into @ groups , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25675562", "label": "methods", "text": "Separately , @ factors and each different @ levels were adopted in treatment , named acupuncture timing ( factor A : A , acute stage , A@ adhesion stage ) , acupoint combination ( factor B : B , local acupoints , B@ local acupoints and distal acupoints along meridians ) , filiform needling and warm needling therapy ( factor C : C@ acupuncture with filiform needle , CZ acupuncture with filiform needle and warm needling therapy ) and positive functional exercise ( factor D : D@ without positive functional exercise , D@ with positive functional exercise ) .", "sentence_id": 2}
+{"abstract_id": "25675562", "label": "methods", "text": "The treatment was given once a day , @ treatments made one session and @ sessions were required totally .", "sentence_id": 3}
+{"abstract_id": "25675562", "label": "methods", "text": "The time points of observation were the point after @ session of treatment and after @ sessions of treatment .", "sentence_id": 4}
+{"abstract_id": "25675562", "label": "methods", "text": "The short-form McGill pain questionnaire ( MPQ ) and shoulder joint motor disturbance score were adopted for evaluation .", "sentence_id": 5}
+{"abstract_id": "25675562", "label": "results", "text": "In the orthogonal design analysis , taking the hierarchical factors into consideration , the age was considered as the main factor in the evaluation of shoulder pain and shoulder motor disturbance ( P < @ ) , and the shoulder function grade apparently impacted pain evaluation and the efficacy on shoulder motor disturbance ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25675562", "label": "results", "text": "The best combination of @ factors and @ levels were A@B@CzD@ and A@ BC@D@ .", "sentence_id": 7}
+{"abstract_id": "25675562", "label": "results", "text": "SAS statistical analysis showed that at acute stage and adhesion stage , CZ Dz , meaning acupuncture with fifiform needling and warm needling therapy combined with positive functional exercise , is the main factor of the improvements of shoulder motor function ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25675562", "label": "conclusions", "text": "For periarthritis of shoulder at acute stage , the combined therapy of acupuncture at local acupoints , warm needling and positive functional exercise is adopted .", "sentence_id": 9}
+{"abstract_id": "25675562", "label": "conclusions", "text": "At chronic stage , the combined therapy of acupuncture at local acupoints and distal acupoints , acupuncture with filiform needle and warm needling and positive functional exercise is the best program .", "sentence_id": 10}
+{"abstract_id": "25675562", "label": "conclusions", "text": "Additionally , in clinical treatment , the patients ' age , sex , shoulder joint function and duration of treatment should be considered comprehensively for the impacts on the efficacy .", "sentence_id": 11}
+{"abstract_id": "25407349", "label": "background", "text": "Inappropriate drug use has been identified as one of the most important problems affecting the quality of care in older people .", "sentence_id": 0}
+{"abstract_id": "25407349", "label": "background", "text": "Inappropriate drug use may increase the risk of the occurrence of ` geriatric giants ' such as immobility , instability , incontinence and cognitive impairment .", "sentence_id": 1}
+{"abstract_id": "25407349", "label": "background", "text": "There are indications that clinical medication reviews ( CMR ) can reduce inappropriate drug use .", "sentence_id": 2}
+{"abstract_id": "25407349", "label": "background", "text": "However , CMRs have not yet been implemented at a large scale in primary care .", "sentence_id": 3}
+{"abstract_id": "25407349", "label": "background", "text": "An innovative medication review program in primary care will be developed which tackles the most important obstacles for a large scale implementation of CMRs .", "sentence_id": 4}
+{"abstract_id": "25407349", "label": "background", "text": "The aim of this study is to assess whether this CMR program is ( cost - ) effective compared with usual general practice care for older patients with geriatric symptoms with regard to quality of life and geriatric symptoms .", "sentence_id": 5}
+{"abstract_id": "25407349", "label": "methods", "text": "A cluster randomised controlled trial will be performed in @ Dutch general practices including @ patients .", "sentence_id": 6}
+{"abstract_id": "25407349", "label": "methods", "text": "Patients of @years and older are eligible if they newly present with pre-specified geriatric symptoms in general practice and chronic use of at least one prescribed drug .", "sentence_id": 7}
+{"abstract_id": "25407349", "label": "methods", "text": "GP practices will be stratified by practice size and randomly allocated to control ( n = @ ) or intervention group ( n = @ ) .", "sentence_id": 8}
+{"abstract_id": "25407349", "label": "methods", "text": "The intervention consists of CMRs which will be facilitated and prepared by an expert team consisting of a GP and a pharmacist .", "sentence_id": 9}
+{"abstract_id": "25407349", "label": "methods", "text": "Primary outcome measures are patient 's quality of life and the presence of self-reported geriatric symptoms during a follow-up period of @months .", "sentence_id": 10}
+{"abstract_id": "25407349", "label": "methods", "text": "Secondary outcomes are costs of healthcare utilisation , feasibility , number of drug related problems , medication adherence and satisfaction with medication .", "sentence_id": 11}
+{"abstract_id": "25407349", "label": "conclusions", "text": "This study is expected to add evidence on the ( cost - ) effectiveness of an optimally facilitated , prepared and structured CMR in comparison with usual care in older patients who present a geriatric symptom to their GP .", "sentence_id": 12}
+{"abstract_id": "25407349", "label": "conclusions", "text": "The strength of this study is that it will be conducted in daily clinical practice .", "sentence_id": 13}
+{"abstract_id": "25407349", "label": "conclusions", "text": "This improves the possibilities to implement the CMRs in the primary care setting on a large scale .", "sentence_id": 14}
+{"abstract_id": "24973836", "label": "objective", "text": "To evaluate the safety and efficacy of various initial strategies of loop diuretic administration in patients with acute decompensated heart failure ( ADHF ) on diuresis , renal function , electrolyte balance and clinical outcomes .", "sentence_id": 0}
+{"abstract_id": "24973836", "label": "methods", "text": "Consecutive patients admitted with ADHF were randomized into three groups - intravenous furosemide infusion + intravenous dopamine , intravenous furosemide bolus in two divided doses and intravenous furosemide continuous infusion alone .", "sentence_id": 1}
+{"abstract_id": "24973836", "label": "methods", "text": "At @h , the treating physician could adjust the diuretic strategy .", "sentence_id": 2}
+{"abstract_id": "24973836", "label": "methods", "text": "Primary endpoint was negative fluid balance at @h after admission .", "sentence_id": 3}
+{"abstract_id": "24973836", "label": "methods", "text": "Secondary end points were duration of hospital stay , negative fluid balance at @ , @ , @h , the trend of serum electrolytes , and renal function and @ day clinical outcome ( death and emergency department visits ) .", "sentence_id": 4}
+{"abstract_id": "24973836", "label": "results", "text": "Overall ninety patients ( thirty in each group ) were included in the study .", "sentence_id": 5}
+{"abstract_id": "24973836", "label": "results", "text": "There was a greater diuresis in first @h ( p = @ ) and a shorter hospital stay ( p = @ ) with the bolus group .", "sentence_id": 6}
+{"abstract_id": "24973836", "label": "results", "text": "There was no significant difference in renal function and serum sodium and serum potassium levels .", "sentence_id": 7}
+{"abstract_id": "24973836", "label": "results", "text": "There was no difference in the number of emergency department visits among the three groups .", "sentence_id": 8}
+{"abstract_id": "24973836", "label": "conclusions", "text": "All three modes of diuretic therapies can be practiced with no difference in worsening of renal function and electrolyte levels .", "sentence_id": 9}
+{"abstract_id": "24973836", "label": "conclusions", "text": "Bolus dose administration with itsrapid volume loss and shorter hospital stay might be a more effective diuretic strategy .", "sentence_id": 10}
+{"abstract_id": "24932893", "label": "background", "text": "Missed scheduled HIV appointments lead to increased mortality , resistance to antiretroviral therapy , and suboptimum virological response .", "sentence_id": 0}
+{"abstract_id": "24932893", "label": "background", "text": "We aimed to assess whether reminders sent to carers by text message , mobile phone call , or concomitant text message and mobile phone call increase attendance at medical appointments for HIV care in a population of children infected with or exposed to HIV in Cameroon .", "sentence_id": 1}
+{"abstract_id": "24932893", "label": "background", "text": "We also aimed to ascertain the most cost-effective method of mobile-phone-based reminder .", "sentence_id": 2}
+{"abstract_id": "24932893", "label": "methods", "text": "MORE CARE was a multicentre , single-blind , factorial , randomised controlled trial in urban , semi-urban , and rural settings in Cameroon .", "sentence_id": 3}
+{"abstract_id": "24932893", "label": "methods", "text": "Carers of children who were infected with or had been exposed to HIV were randomly assigned electronically in blocks of four and allocated ( @:@:@:@ ) sequentially to receive a text message and a call , a text message only , a call only , or no reminder ( control ) .", "sentence_id": 4}
+{"abstract_id": "24932893", "label": "methods", "text": "Investigators were masked to group assignment .", "sentence_id": 5}
+{"abstract_id": "24932893", "label": "methods", "text": "Text messages were sent and calls made @ or @ days before a scheduled follow-up appointment .", "sentence_id": 6}
+{"abstract_id": "24932893", "label": "methods", "text": "The primary outcomes were efficacy ( the proportion of patients attending a previously scheduled appointment ) and efficiency ( attendance / -LSB- measures of staff working time cost of the reminders -RSB- ) , as a measure of cost-effectiveness .", "sentence_id": 7}
+{"abstract_id": "24932893", "label": "methods", "text": "The primary analysis was by intention to treat .", "sentence_id": 8}
+{"abstract_id": "24932893", "label": "methods", "text": "This study is registered with the Pan African Clinical Trials Register , number PACTR@ .", "sentence_id": 9}
+{"abstract_id": "24932893", "label": "results", "text": "The study took place between Jan @ and May @ , @ .", "sentence_id": 10}
+{"abstract_id": "24932893", "label": "results", "text": "We randomly assigned @ adult-child ( carer-patient ) pairs into four groups : text message plus call ( n = @ ) , call ( n = @ ) , text message ( n = @ ) , and control ( n = @ ) .", "sentence_id": 11}
+{"abstract_id": "24932893", "label": "results", "text": "@ participants ( @ % ) in the text message plus call group , @ ( @ % ) in the call group , @ ( @ % ) in the text message group , and @ ( @ % ) in the control group attended their scheduled appointment .", "sentence_id": 12}
+{"abstract_id": "24932893", "label": "results", "text": "Compared with control , the odds ratios for improvement in the primary efficacy outcome were @ ( @ % CI @-@ ; p < @ ) for text message plus call , @ ( @-@ ; p = @ ) for call , and @ ( @-@ ; p = @ ) for text message .", "sentence_id": 13}
+{"abstract_id": "24932893", "label": "results", "text": "No significant differences were seen in comparisons of the three intervention groups with each other , and there was no synergism between text messages and calls .", "sentence_id": 14}
+{"abstract_id": "24932893", "label": "results", "text": "For the primary efficiency outcome , the mean difference for text message versus text message plus call was @ ( @ % CI @ to @ ; p = @ ) , for call versus text message plus call was @ ( @ to @ ; p < @ ) , and for call versus text message was @ ( -@ to @ ; p = @ ) .", "sentence_id": 15}
+{"abstract_id": "24932893", "label": "conclusions", "text": "Mobile-phone-based reminders of scheduled HIV appointments for carers of paediatric patients in low-resource settings can increase attendance .", "sentence_id": 16}
+{"abstract_id": "24932893", "label": "conclusions", "text": "The most effective method of reminder was text message plus phone call , but text messaging alone was the most efficient ( ie , cost-effective ) method .", "sentence_id": 17}
+{"abstract_id": "26017658", "label": "background", "text": "Safe and cost-effective programs for implementing early infant male circumcision ( EIMC ) in Africa need to be piloted .", "sentence_id": 0}
+{"abstract_id": "26017658", "label": "background", "text": "We present results on a relative cost analysis within a randomized noninferiority trial of EIMC comparing the AccuCirc device with Mogen clamp in Zimbabwe .", "sentence_id": 1}
+{"abstract_id": "26017658", "label": "methods", "text": "Between January and June @ , male infants who met inclusion criteria were randomized to EIMC through either AccuCirc or Mogen clamp conducted by a doctor , using a @:@ allocation ratio .", "sentence_id": 2}
+{"abstract_id": "26017658", "label": "methods", "text": "We evaluated the overall unit cost plus the key cost drivers of EIMC using both AccuCirc and Mogen clamp .", "sentence_id": 3}
+{"abstract_id": "26017658", "label": "methods", "text": "Direct costs included consumable and nonconsumable supplies , device , personnel , associated staff training , and environmental costs .", "sentence_id": 4}
+{"abstract_id": "26017658", "label": "methods", "text": "Indirect costs comprised capital and support personnel costs .", "sentence_id": 5}
+{"abstract_id": "26017658", "label": "methods", "text": "In @-way sensitivity analyses , we assessed potential changes in unit costs due to variations in main parameters , one at a time , holding all other values constant .", "sentence_id": 6}
+{"abstract_id": "26017658", "label": "results", "text": "The unit costs of EIMC using AccuCirc and Mogen clamp were $ @ and $ @ , respectively .", "sentence_id": 7}
+{"abstract_id": "26017658", "label": "results", "text": "Key cost drivers were consumable supplies , capacity utilization , personnel costs , and device price .", "sentence_id": 8}
+{"abstract_id": "26017658", "label": "results", "text": "Unit prices are likely to be lowest at full capacity utilization and increase as capacity utilization decreases .", "sentence_id": 9}
+{"abstract_id": "26017658", "label": "results", "text": "Unit prices also fall with lower personnel salaries and increase with higher device prices .", "sentence_id": 10}
+{"abstract_id": "26017658", "label": "conclusions", "text": "EIMC has a lower unit cost when using AccuCirc compared with Mogen clamp .", "sentence_id": 11}
+{"abstract_id": "26017658", "label": "conclusions", "text": "To minimize unit costs , countries planning to scale-up EIMC using AccuCirc need to control costs of consumables and personnel .", "sentence_id": 12}
+{"abstract_id": "26017658", "label": "conclusions", "text": "There is also need to negotiate a reasonable device price and maximize capacity utilization .", "sentence_id": 13}
+{"abstract_id": "24471786", "label": "background", "text": "A number of perioperative risk factors may suppress the immune system and contribute to the development of post-operative complications .", "sentence_id": 0}
+{"abstract_id": "24471786", "label": "background", "text": "The association between surgical site infection ( SSI ) and other wound-related complications resulting from immunosuppression through either perioperative administration of dexamethasone , pre-operative smoking or alcohol abuse is , however , uncertain .", "sentence_id": 1}
+{"abstract_id": "24471786", "label": "methods", "text": "This study was a post hoc analysis of data from the PROXI randomized trial in @ patients who underwent emergency or elective laparotomy .", "sentence_id": 2}
+{"abstract_id": "24471786", "label": "methods", "text": "We assessed the associations of use of dexamethasone , smoking status and alcohol abuse with the primary outcome , being a composite of SSI , anastomotic leak , wound dehiscence , burst abdomen and @-day mortality .", "sentence_id": 3}
+{"abstract_id": "24471786", "label": "results", "text": "The primary outcome occurred in @ % of patients receiving dexamethasone versus @ % of patients not receiving dexamethasone , and this was not statistically significant when adjusting for stratification variables originally used in the PROXI trial -LSB- OR @ , @ % CI ( @-@ @ ) -RSB- .", "sentence_id": 4}
+{"abstract_id": "24471786", "label": "results", "text": "In smokers , the primary outcome occurred in @ % , compared with @ % of non-smokers ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24471786", "label": "results", "text": "Smokers also had a higher frequency of SSI ( @ % vs @ % , P < @ ) and burst abdomen ( @ % vs @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24471786", "label": "results", "text": "In alcohol abusers , the primary outcome occurred in @ % , compared with @ % in patients who did not abuse alcohol ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24471786", "label": "results", "text": "Burst abdomen occurred more commonly in alcohol abusers ( @ % vs @ % , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24471786", "label": "conclusions", "text": "Perioperative administration of dexamethasone was not significantly associated with SSI or other wound-related complications .", "sentence_id": 9}
+{"abstract_id": "24471786", "label": "conclusions", "text": "Conversely , smoking and alcohol abuse were both significant predictors of the primary outcome consisting of wound-related complications and mortality .", "sentence_id": 10}
+{"abstract_id": "25481453", "label": "background", "text": "While research suggests primary prescription opioid ( PO ) abusers may exhibit less severe demographic and drug use characteristics than primary heroin abusers , less is known about whether a lifetime history of heroin use confers greater severity among PO abusers .", "sentence_id": 0}
+{"abstract_id": "25481453", "label": "objective", "text": "In this secondary analysis , we examined demographic and drug use characteristics as a function of lifetime heroin use among @ PO-dependent adults screened for a trial evaluating the relative efficacy of buprenorphine taper durations .", "sentence_id": 1}
+{"abstract_id": "25481453", "label": "objective", "text": "Exploratory analyses also examined contribution of lifetime heroin use to treatment response among a subset of participants who received a uniform set of study procedures .", "sentence_id": 2}
+{"abstract_id": "25481453", "label": "methods", "text": "Baseline characteristics were compared between participants reporting lifetime heroin use @ ( H ( + ) ; n = @ ) vs. < @ ( H ( - ) ; n = @ ) times .", "sentence_id": 3}
+{"abstract_id": "25481453", "label": "methods", "text": "Treatment response ( i.e. , illicit opioid abstinence and treatment retention at end of study ) was examined in the subset of H ( + ) and H ( - ) participants randomized to receive the @-week taper condition ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "25481453", "label": "results", "text": "H ( + ) participants were significantly older and more likely to be male .", "sentence_id": 5}
+{"abstract_id": "25481453", "label": "results", "text": "They reported longer durations of illicit opioid use , greater alcohol-related problems , more past-month cocaine use , greater lifetime IV drug use , and greater lifetime use of cigarettes , amphetamines and hallucinogens .", "sentence_id": 6}
+{"abstract_id": "25481453", "label": "results", "text": "H ( + ) participants also had lower scores on the Positive Symptom Distress and Depression subscales of the Brief Symptom Inventory .", "sentence_id": 7}
+{"abstract_id": "25481453", "label": "results", "text": "Finally , there was a trend toward poorer treatment outcomes among H ( + ) participants .", "sentence_id": 8}
+{"abstract_id": "25481453", "label": "conclusions", "text": "A lifetime history of heroin use may be associated with elevated drug severity and unique treatment needs among treatment-seeking PO abusers .", "sentence_id": 9}
+{"abstract_id": "24830824", "label": "objective", "text": "To evaluate the onset and duration of improvement in best-corrected visual acuity ( BCVA ) in eyes treated with dexamethasone intravitreal implant @ mg ( DEX implant ) for macular edema after branch or central retinal vein occlusion .", "sentence_id": 0}
+{"abstract_id": "24830824", "label": "methods", "text": "Post hoc analysis of data from @ previously reported multicenter , @-month , randomized sham-controlled clinical trials .", "sentence_id": 1}
+{"abstract_id": "24830824", "label": "methods", "text": "Patients received a single DEX implant ( n = @ ) or sham procedure ( n = @ ) in the study eye .", "sentence_id": 2}
+{"abstract_id": "24830824", "label": "methods", "text": "The primary endpoint was the percentage of eyes with @-letter improvement in BCVA from baseline at postimplant Day @ .", "sentence_id": 3}
+{"abstract_id": "24830824", "label": "results", "text": "The baseline mean BCVA was @/@ .", "sentence_id": 4}
+{"abstract_id": "24830824", "label": "results", "text": "At Day @ , @ % of DEX implant-treated eyes versus @ % of sham-treated eyes ( P < @ ) had @-letter improvement in the BCVA , and @ % of DEX implant-treated eyes versus @ % of sham-treated eyes had @-letter improvement ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24830824", "label": "results", "text": "The mean improvement at Day @ was @ letters ( branch retinal vein occlusion , @ ; and central retinal vein occlusion , @ ) with DEX implant and @ letters ( branch retinal vein occlusion , @ ; and central retinal vein occlusion , @ ) with sham ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24830824", "label": "results", "text": "The mean time from initial observation of @-letter BCVA gain to the last observation of @-letter BCVA gain was @ days .", "sentence_id": 7}
+{"abstract_id": "24830824", "label": "conclusions", "text": "Dexamethasone intravitreal implant treatment led to improvement in BCVA compared with sham procedure as early as postimplant Day @ .", "sentence_id": 8}
+{"abstract_id": "24830824", "label": "conclusions", "text": "The duration of @-line improvement was typically @ to @ months .", "sentence_id": 9}
+{"abstract_id": "24937967", "label": "objective", "text": "To investigate the effect of luteal phase support with vaginal progesterone on pregnancy rates of the gonadotropin-stimulated intrauterine insemination ( IUI ) cycles in patients with unexplained infertility with regard tofollicular growth .", "sentence_id": 0}
+{"abstract_id": "24937967", "label": "methods", "text": "A total of @ patients with unexplained infertility who underwent @ recombinant follicle stimulated hormone -- stimulated IUI cycles were prospectively randomized into @ groups for luteal phase support .", "sentence_id": 1}
+{"abstract_id": "24937967", "label": "methods", "text": "The study group ( n = @ ) received vaginal progesterone gel supplementation , and the control group ( n = @ ) received no drug for luteal support .", "sentence_id": 2}
+{"abstract_id": "24937967", "label": "methods", "text": "The clinical pregnancy rates and live birth rates per cycle and per patient were compared between the groups .", "sentence_id": 3}
+{"abstract_id": "24937967", "label": "results", "text": "The differences between the groups with regard to clinical pregnancy rates and live birth rates per patient or per cycle were not different among all patients .", "sentence_id": 4}
+{"abstract_id": "24937967", "label": "results", "text": "In cycles with > @ dominant follicle ( multifollicular response ) , the clinical pregnancy rate per patient was significantly higher in the supported cycles as compared with the unsupported cycles ( @ % vs. @ % , respectively , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24937967", "label": "results", "text": "Reproductive outcomes in cycles with a single dominant follicle ( monofollicular response ) were not different between supported and unsupported cycles .", "sentence_id": 6}
+{"abstract_id": "24937967", "label": "conclusions", "text": "Luteal phase support with vaginal progesterone affects the success of gonadotropin-stimulated IUI cycles with multifollicular response but not with monofollicular response .", "sentence_id": 7}
+{"abstract_id": "25559798", "label": "objective", "text": "Linifanib , a potent , selective inhibitor of vascular endothelial growth factor ( VEGF ) and platelet-derived growth factor ( PDGF ) receptors , has single-agent activity in non-small-cell lung cancer ( NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "25559798", "label": "objective", "text": "We evaluated linifanib with carboplatin and paclitaxel as first-line therapy of advanced nonsquamous NSCLC .", "sentence_id": 1}
+{"abstract_id": "25559798", "label": "methods", "text": "Patients with stage IIIB/IV nonsquamous NSCLC were randomly assigned to @-week cycles of carboplatin ( area under the curve @ ) and paclitaxel ( @ mg/m ( @ ) ) with daily placebo ( arm A ) , linifanib @ mg ( arm B ) , or linifanib @ mg ( arm C ) .", "sentence_id": 2}
+{"abstract_id": "25559798", "label": "methods", "text": "The primary end point was progression-free survival ( PFS ) ; secondary efficacy end points included overall survival ( OS ) and objective response rate .", "sentence_id": 3}
+{"abstract_id": "25559798", "label": "results", "text": "One hundred thirty-eight patients were randomly assigned ( median age , @ years ; @ % men ; @ % smokers ) .", "sentence_id": 4}
+{"abstract_id": "25559798", "label": "results", "text": "Median PFS times were @ months ( @ % CI , @ to @ months ) in arm A ( n = @ ) , @ months ( @ % CI , @ to @ months ) in arm B ( n = @ ) , and @ months ( @ % CI , @ to @ months ) in arm C ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25559798", "label": "results", "text": "Hazard ratios ( HRs ) for PFS were @ for arm B versus A ( P = @ ) and @ for arm C versus A ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25559798", "label": "results", "text": "Median OS times were @ , @ , and @ months in arms A , B , and C , respectively .", "sentence_id": 7}
+{"abstract_id": "25559798", "label": "results", "text": "HRs for OS were @ for arm B versus A ( P = @ ) and @ for arm C versus A ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25559798", "label": "results", "text": "Both linifanib doses were associated with increased toxicity , including a higher incidence of adverse events known to be associated with VEGF/PDGF inhibition .", "sentence_id": 9}
+{"abstract_id": "25559798", "label": "results", "text": "Baseline plasma carcinoembryonic antigen/cytokeratin @ fragments biomarker signature was associated with PFS improvement and a trend toward OS improvement with linifanib @ mg .", "sentence_id": 10}
+{"abstract_id": "25559798", "label": "conclusions", "text": "Addition of linifanib to chemotherapy significantly improved PFS ( arm B ) , with a modest trend for survival benefit ( arm C ) and increased toxicity reflective of known VEGF/PDGF inhibitory effects .", "sentence_id": 11}
+{"abstract_id": "24447629", "label": "objective", "text": "To compare the effects of two of the most effective lipid-lowering therapies with similar LDL-cholesterol reduction capacity on the innate and adaptive immune responses through the evaluation of autoantibodies anti-oxidized LDL ( anti-oxLDL Abs ) and electronegative LDL -LSB- LDL ( - ) -RSB- levels .", "sentence_id": 0}
+{"abstract_id": "24447629", "label": "methods", "text": "We performed a prospective , randomized , open label study , with parallel arms and blinded endpoints .", "sentence_id": 1}
+{"abstract_id": "24447629", "label": "methods", "text": "One hundred and twelve subjects completed the study protocol and received rosuvastatin @ mg or ezetimibe/simvastatin @/@ mg for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24447629", "label": "methods", "text": "Lipids , apolipoproteins , LDL ( - ) , and anti-oxLDL Abs ( IgG ) were assayed at baseline and end of study .", "sentence_id": 3}
+{"abstract_id": "24447629", "label": "results", "text": "Main clinical and laboratory characteristics were comparable at baseline .", "sentence_id": 4}
+{"abstract_id": "24447629", "label": "results", "text": "Lipid modifications were similar in both treatment arms , however , a significant raise in anti-oxLDL Abs levels was observed in subjects treated with rosuvastatin ( p = @ vs. baseline ) , but not in those receiving simvastatin/ezetimibe .", "sentence_id": 5}
+{"abstract_id": "24447629", "label": "results", "text": "( p = @ vs. baseline ) , thus suggesting modulation of adaptive immunity by a potent statin .", "sentence_id": 6}
+{"abstract_id": "24447629", "label": "results", "text": "Titers of LDL ( - ) were not modified by the treatments .", "sentence_id": 7}
+{"abstract_id": "24447629", "label": "conclusions", "text": "Considering atherosclerosis as an immune disease , this study adds new information , showing that under similar LDL-cholesterol reduction , the choice of lipid-lowering therapy can differently modulate adaptive immune responses .", "sentence_id": 8}
+{"abstract_id": "26376528", "label": "objective", "text": "The aim of the study was to compare two techniques of pyramidalis muscle dissection during cesarean section .", "sentence_id": 0}
+{"abstract_id": "26376528", "label": "methods", "text": "A total of @ patients undergoing a cesarean section were randomly allocated to group I ( N = @ ) , with the pyramidalis muscle left attached to the rectus muscles , and group II ( N = @ ) , with preservation of the connection between the pyramidalis muscle and the rectus sheath .", "sentence_id": 1}
+{"abstract_id": "26376528", "label": "results", "text": "There were no statistically significant differences between the groups regarding surgery duration , blood loss and postoperative pain .", "sentence_id": 2}
+{"abstract_id": "26376528", "label": "results", "text": "After three months , patients from group II more frequently reported paresthesia in the scar region ( @ vs. @ % ; p = @ ) , but their self-assessment of the abdominal appearance and presence of the bulging below the wound were comparable with group I.", "sentence_id": 3}
+{"abstract_id": "26376528", "label": "conclusions", "text": "None of the two techniques of pyramidalis muscle dissection appear to be superior to the other .", "sentence_id": 4}
+{"abstract_id": "26376528", "label": "conclusions", "text": "The technique leaving the pyramidalis muscle attached to the fascia gave more frequent paresthesia during a @-month follow-up .", "sentence_id": 5}
+{"abstract_id": "24325778", "label": "background", "text": "The importance of functional properties of high-density lipoproteins ( HDL ) for atheroprotection is increasingly recognized .", "sentence_id": 0}
+{"abstract_id": "24325778", "label": "background", "text": "We determined the impact of lipid-lowering therapy on @ key HDL functionalities in Type @ diabetes mellitus ( T@DM ) .", "sentence_id": 1}
+{"abstract_id": "24325778", "label": "methods", "text": "A placebo-controlled , randomized cross-over study ( three @-week treatment periods with simvastatin ( @ mg daily ) , bezafibrate ( @ mg daily ) , alone and in combination ) was carried out in @ men with T@DM .", "sentence_id": 2}
+{"abstract_id": "24325778", "label": "methods", "text": "Cholesterol efflux was determined using human THP-@ monocyte-derived macrophages , HDL antioxidative capacity was measured as inhibition of low-density lipoprotein oxidation in vitro , and HDL anti-inflammatory capacity was assessed as suppression of thrombin-induced monocyte chemotactic protein @ expression in human umbilical vein endothelial cells .", "sentence_id": 3}
+{"abstract_id": "24325778", "label": "methods", "text": "Pre -- HDL was assayed using crossed immunoelectrophoresis .", "sentence_id": 4}
+{"abstract_id": "24325778", "label": "results", "text": "While cholesterol efflux increased in response to simvastatin , bezafibrate and combination treatment ( +@ to +@ % ; anova , P = @ ) , HDL antioxidative capacity ( P = @ ) and HDL anti-inflammatory capacity ( P = @ ) did not change significantly .", "sentence_id": 5}
+{"abstract_id": "24325778", "label": "results", "text": "Averaged changes in cellular cholesterol efflux during active treatment were correlated positively with changes in HDL cholesterol , apoA-I and pre -- HDL ( P < @ to P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24325778", "label": "results", "text": "There were no inter-relationships between changes in the three HDL functionalities during treatment ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24325778", "label": "results", "text": "Changes in HDL antioxidative capacity and anti-inflammatory capacity were also unrelated to changes in HDL cholesterol and apoA-I , while changes in HDL antioxidative capacity were related inversely to pre -- HDL ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24325778", "label": "conclusions", "text": "Simvastatin and bezafibrate increase cholesterol efflux , parallel to HDL cholesterol and apoA-I responses .", "sentence_id": 9}
+{"abstract_id": "24325778", "label": "conclusions", "text": "The antioxidative and anti-inflammatory properties of HDL are not to an important extent affected by these therapeutic interventions .", "sentence_id": 10}
+{"abstract_id": "24561014", "label": "objective", "text": "Regulatory Foxp@-expressing T cells ( Tregs ) , IL-@-producing B cells ( Bregs ) , and IDO-expressing dendritic cells ( DCregs ) downregulate inflammatory processes and induce peripheral tolerance , while Th@A and Th@ cell subpopulations are of proinflammatory nature .", "sentence_id": 0}
+{"abstract_id": "24561014", "label": "objective", "text": "The aims of the study were to characterize and to enumerate peripheral Tregs , Bregs , and DCregs and Th@A and Th@ cell subpopulations in kidney transplant recipients ( KTRs ) under belatacept or cyclosporine treatment .", "sentence_id": 1}
+{"abstract_id": "24561014", "label": "methods", "text": "Forty-one KRT patients ( @ under belatacept treatment and @ under cyclosporine treatment ) and @ healthy donors ( HDs ) were included in the study .", "sentence_id": 2}
+{"abstract_id": "24561014", "label": "methods", "text": "CD@ ( + ) - expressing peripheral B lymphocytes were purified by positive selection .", "sentence_id": 3}
+{"abstract_id": "24561014", "label": "methods", "text": "IL-@-producing B cells , CD@ ( + ) / CD@ ( high ) Foxp@ ( + ) , and CD@ ( + ) / CD@ ( - ) Foxp@ ( + ) Tregs , CCR@ ( + ) / CD@ ( + ) / IDO ( + ) DCs , as well as Th@A and Th@ cell subpopulations were quantitated by flow cytometry .", "sentence_id": 4}
+{"abstract_id": "24561014", "label": "results", "text": "Of the IL-@-producing Bregs , CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CD@ ( + ) , CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CD@ ( + ) , CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CD@ ( + ) , and CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CD@ ( - ) had significant higher frequency in patients under belatacept treatment when compared with those under cyclosporine .", "sentence_id": 5}
+{"abstract_id": "24561014", "label": "results", "text": "Only CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CD@ ( + ) and CD@ ( + ) / CD@ ( high ) / CD@ ( high ) / CXCR@ ( + ) cells had significant higher frequency in patients under cycloporine treatment when compared to those under belatacept .", "sentence_id": 6}
+{"abstract_id": "24561014", "label": "results", "text": "The percentages of IDO-expressing pDC , CD@ ( + ) / CD@ ( high ) Foxp@ ( + ) , and CD@ ( + ) / CD@ ( - ) Foxp@ ( + ) were significantly higher in the belatacept group when compared the cyclosporine one , while Th@A and Th@ cells had significant higher frequency in the latter group .", "sentence_id": 7}
+{"abstract_id": "24561014", "label": "conclusions", "text": "Belatacept seems to maintain and enhance , at least systemically , a tolerant profile to renal allograft in transplant recipients by means of higher circulatory frequencies of regulatory B , T and pDC subpopulations .", "sentence_id": 8}
+{"abstract_id": "25478898", "label": "background", "text": "In the United Kingdom , patients with locally advanced rectal cancer routinely receive neoadjuvant chemoradiotherapy .", "sentence_id": 0}
+{"abstract_id": "25478898", "label": "background", "text": "However , the effects of this on physical fitness are unclear .", "sentence_id": 1}
+{"abstract_id": "25478898", "label": "background", "text": "This pilot study is aimed to investigate the effect of neoadjuvant chemoradiotherapy on objectively measured in vivo muscle mitochondrial function and whole-body physical fitness .", "sentence_id": 2}
+{"abstract_id": "25478898", "label": "methods", "text": "We prospectively studied @ patients with rectal cancer who completed standardized neoadjuvant chemoradiotherapy , recruited from a large tertiary cancer centre , between October @ and July @ .", "sentence_id": 3}
+{"abstract_id": "25478898", "label": "methods", "text": "All patients underwent a cardiopulmonary exercise test and a phosphorus magnetic resonance spectroscopy quadriceps muscle exercise-recovery study before and after neoadjuvant chemoradiotherapy .", "sentence_id": 4}
+{"abstract_id": "25478898", "label": "methods", "text": "Data were analysed and reported blind to patient identity and clinical course .", "sentence_id": 5}
+{"abstract_id": "25478898", "label": "methods", "text": "Primary variables of interest were the two physical fitness measures ; oxygen uptake at estimated anaerobic threshold and oxygen uptake at Peak exercise ( ml.kg-@ .", "sentence_id": 6}
+{"abstract_id": "25478898", "label": "methods", "text": "min-@ ) , and the post-exercise phosphocreatine recovery rate constant ( min-@ ) , a measure of muscle mitochondrial capacity in vivo .", "sentence_id": 7}
+{"abstract_id": "25478898", "label": "results", "text": "Median age was @ years ( IQR @-@ ) .", "sentence_id": 8}
+{"abstract_id": "25478898", "label": "results", "text": "Differences ( @ % CI ) in all three primary variables were significantly negative post-NACRT : Oxygen uptake at estimated anaerobic threshold -@ ml.kg-@ .", "sentence_id": 9}
+{"abstract_id": "25478898", "label": "results", "text": "min-@ ( -@ , -@ ) , p = @ ; Oxygen uptake at Peak -@ ml.kg-@ .", "sentence_id": 10}
+{"abstract_id": "25478898", "label": "results", "text": "min-@ ( -@ , -@ ) , p = @ ; and post-exercise phosphocreatine recovery rate constant -@ min-@ ( -@ , -@ ) , p < @ .", "sentence_id": 11}
+{"abstract_id": "25478898", "label": "conclusions", "text": "The significant decrease in both whole-body physical fitness and in vivo muscle mitochondrial function raises the possibility that muscle mitochondrial mechanisms , no doubt multifactorial , may be important in deterioration of physical fitness following neoadjuvant chemoradiotherapy .", "sentence_id": 12}
+{"abstract_id": "25478898", "label": "conclusions", "text": "This may have implications for targeted interventions to improve physical fitness pre-surgery .", "sentence_id": 13}
+{"abstract_id": "24356398", "label": "objective", "text": "To evaluate the effect of periodontal treatment on gingival overgrowth in a group of renal transplant patients .", "sentence_id": 0}
+{"abstract_id": "24356398", "label": "methods", "text": "Twenty-five renal transplant recipients receiving immunosuppressive therapy with cyclosporine A ( CsA ) were randomly assigned to @ groups .", "sentence_id": 1}
+{"abstract_id": "24356398", "label": "methods", "text": "Group @ ( n = @ ) included patients who had been specifically referred to a dental clinic to prevent gingival overgrowth and were given full periodontal therapy .", "sentence_id": 2}
+{"abstract_id": "24356398", "label": "methods", "text": "Group @ ( n = @ ) was comprised of patients who did not receive any professional periodontal cleaning .", "sentence_id": 3}
+{"abstract_id": "24356398", "label": "methods", "text": "Patients from both groups were examined to determine their periodontal status before and after @ , @ and @ months in terms of their plaque index , gingival index and gingival overgrowth .", "sentence_id": 4}
+{"abstract_id": "24356398", "label": "methods", "text": "During the examination , their overall health was stable .", "sentence_id": 5}
+{"abstract_id": "24356398", "label": "results", "text": "For group @ , the scores were @ ( baseline ) , @ ( @ months ) and @ ( @ months ) , and hence there were significant reductions ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24356398", "label": "results", "text": "The gingival indices were @ ( baseline ) , @ ( @ months ) and @ ( @ months ) , and the reductions were also significant ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24356398", "label": "results", "text": "A significant association was observed between poor oral hygiene and the degree of gingival overgrowth .", "sentence_id": 8}
+{"abstract_id": "24356398", "label": "results", "text": "The @-year post-treatment follow-up showed that patients in group @ did not develop gingival overgrowth due to the use of CsA as group @ did without prior periodontal therapy .", "sentence_id": 9}
+{"abstract_id": "24356398", "label": "conclusions", "text": "Oral hygiene status was the most important variable related to the development and degree of gingival overgrowth due to the use of CsA .", "sentence_id": 10}
+{"abstract_id": "24275900", "label": "objective", "text": "The use of heat and moisture exchangers ( HME ) during noninvasive ventilation ( NIV ) can increase the work of breathing , decrease alveolar ventilation , and deliver less humidity in comparison with heated humidifiers ( HH ) .", "sentence_id": 0}
+{"abstract_id": "24275900", "label": "objective", "text": "We tested the hypothesis that the use of HH during NIV with ICU ventilators for patients with acute respiratory failure would decrease the rate of intubation ( primary endpoint ) as compared with HME .", "sentence_id": 1}
+{"abstract_id": "24275900", "label": "methods", "text": "We conducted a multicenter randomized controlled study in @ centers .", "sentence_id": 2}
+{"abstract_id": "24275900", "label": "methods", "text": "After stratification by center and type of respiratory failure ( hypoxemic or hypercapnic ) , eligible patients were randomized to receive NIV with HH or HME .", "sentence_id": 3}
+{"abstract_id": "24275900", "label": "results", "text": "Of the @ patients included , @ patients were allocated to the HME group and @ to the HH group .", "sentence_id": 4}
+{"abstract_id": "24275900", "label": "results", "text": "Patients were comparable at baseline .", "sentence_id": 5}
+{"abstract_id": "24275900", "label": "results", "text": "The intubation rate was not significantly different : @ % in the HME group and @ % in the HH group ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24275900", "label": "results", "text": "PaCO@ did not significantly differ between the two arms , even in the subgroup of hypercapnic patients .", "sentence_id": 7}
+{"abstract_id": "24275900", "label": "results", "text": "No significant difference was observed for NIV duration , ICU and hospital LOS , or ICU mortality ( HME @ vs. HH @ % , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24275900", "label": "conclusions", "text": "In this study , the short-term physiological benefits of HH in comparison with HME during NIV with ICU ventilators were not observed , and no difference in intubation rate was found .", "sentence_id": 9}
+{"abstract_id": "24275900", "label": "conclusions", "text": "The physiologic effects may have been obscured by leaks or other important factors in the clinical settings .", "sentence_id": 10}
+{"abstract_id": "24275900", "label": "conclusions", "text": "This study does not support the recent recommendation favoring the use of HH during NIV with ICU ventilators .", "sentence_id": 11}
+{"abstract_id": "24571855", "label": "background", "text": "Chronic pain can disrupt the cortical representation of a painful body part .", "sentence_id": 0}
+{"abstract_id": "24571855", "label": "background", "text": "This disruption may play a role in maintaining the individual 's pain .", "sentence_id": 1}
+{"abstract_id": "24571855", "label": "background", "text": "Tactile acuity training has been used to normalise cortical representation and reduce pain in certain pain conditions .", "sentence_id": 2}
+{"abstract_id": "24571855", "label": "background", "text": "However , there is little evidence for the effectiveness of this intervention for chronic low back pain ( CLBP ) .", "sentence_id": 3}
+{"abstract_id": "24571855", "label": "background", "text": "The primary aim of this study was to inform the development of a fully powered randomised controlled trial ( RCT ) by providing preliminary data on the effect of tactile acuity training on pain and function in individuals with CLBP .", "sentence_id": 4}
+{"abstract_id": "24571855", "label": "background", "text": "The secondary aim was to obtain qualitative feedback about the intervention .", "sentence_id": 5}
+{"abstract_id": "24571855", "label": "methods", "text": "In this mixed-methods pilot RCT @ individuals were randomised to either an intervention ( tactile acuity training ) or a placebo group ( sham tactile acuity training ) .", "sentence_id": 6}
+{"abstract_id": "24571855", "label": "methods", "text": "All participants received @ sessions of acuity training ( intervention or sham ) from a physiotherapist and were requested to undertake daily acuity home training facilitated by an informal carer ( friend/relative ) .", "sentence_id": 7}
+{"abstract_id": "24571855", "label": "methods", "text": "All participants also received usual care physiotherapy .", "sentence_id": 8}
+{"abstract_id": "24571855", "label": "methods", "text": "The primary outcome measures were pain ( @-@visual analogue scale ( VAS ) ) and function ( Roland Morris Disability Questionnaire ( RMDQ ) ) .", "sentence_id": 9}
+{"abstract_id": "24571855", "label": "methods", "text": "Participants and their informal carers were invited to a focus group to provide feedback on the intervention .", "sentence_id": 10}
+{"abstract_id": "24571855", "label": "results", "text": "The placebo group improved by the greatest magnitude for both outcome measures , but there was no statistically significant difference ( Mean difference ( @ % CI ) , p-value ) between groups for change in pain ( @ ( -@ to @ ) , p = @ ) or function ( @ ( -@ to @ ) , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24571855", "label": "results", "text": "Comparing the number of individuals achieving a minimally clinically significant improvement , the placebo group had better outcomes for pain with all participants achieving @ % improvement compared to only a third of the intervention group ( @/@ vs. @/@ , p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24571855", "label": "results", "text": "Qualitatively , participants reported that needing an informal carer was a considerable barrier to the home training component of the study .", "sentence_id": 13}
+{"abstract_id": "24571855", "label": "conclusions", "text": "This pilot RCT found tactile acuity training to be no more effective than sham tactile acuity training for function and less effective for pain in individuals with CLBP .", "sentence_id": 14}
+{"abstract_id": "24571855", "label": "conclusions", "text": "That the intervention could not be self-applied was a considerable barrier to its use .", "sentence_id": 15}
+{"abstract_id": "25168853", "label": "background", "text": "Chronic obstructive pulmonary disease ( COPD ) is a chronic , progressively debilitating condition that is prevalent in the US and worldwide .", "sentence_id": 0}
+{"abstract_id": "25168853", "label": "background", "text": "Patients suffer from progressive dyspnea and exercise intolerance .", "sentence_id": 1}
+{"abstract_id": "25168853", "label": "background", "text": "Physical exercise is beneficial , but conventional pulmonary rehabilitation programs are underutilized .", "sentence_id": 2}
+{"abstract_id": "25168853", "label": "background", "text": "There remains a need for novel interventions that improve symptoms , quality-of-life , and functional capacity .", "sentence_id": 3}
+{"abstract_id": "25168853", "label": "background", "text": "Tai chi is an increasingly popular mind-body exercise that includes physical exercise , breathing training , mindful awareness , and stress management -- components that are essential to the self-management of COPD .", "sentence_id": 4}
+{"abstract_id": "25168853", "label": "background", "text": "There are , however , limited data on the effectiveness of tai chi as a therapeutic intervention in this population .", "sentence_id": 5}
+{"abstract_id": "25168853", "label": "methods", "text": "The Primary Aims are to evaluate the efficacy , safety , and feasibility of a @-week tai chi program for patients with COPD .", "sentence_id": 6}
+{"abstract_id": "25168853", "label": "methods", "text": "We utilize a randomized controlled trial design , with participants assigned in a @:@ ratio to either a group tai chi program ( N = @ ) or a time/attention-matched education control ( N = @ ) .", "sentence_id": 7}
+{"abstract_id": "25168853", "label": "methods", "text": "Our primary outcomes are COPD-specific quality-of-life and exercise capacity .", "sentence_id": 8}
+{"abstract_id": "25168853", "label": "methods", "text": "Secondary outcomes include dyspnea , mood , functional status , self-efficacy , and lung function .", "sentence_id": 9}
+{"abstract_id": "25168853", "label": "methods", "text": "Cardiopulmonary exercise testing is done in a subset of patients ( N = @ ) .", "sentence_id": 10}
+{"abstract_id": "25168853", "label": "methods", "text": "To explore optimal training duration , a subgroup of patients in tai chi are randomly assigned to complete an additional @ weeks training ( total @ weeks ) ( Exploratory Aim @ ) .", "sentence_id": 11}
+{"abstract_id": "25168853", "label": "methods", "text": "To explore the impact of a simplified seated intervention including only a subset of tai chi 's training components , a third randomly assigned group ( N = @ ) receives a @ - week mind-body breathing program ( N = @ ) ( Exploratory Aim @ ) .", "sentence_id": 12}
+{"abstract_id": "25168853", "label": "conclusions", "text": "Results of the BEAM study ( Breathing , Education , Awareness , Movement ) will provide preliminary evidence regarding the value of tai chi for improving quality of life and exercise capacity in patients with COPD , including information regarding optimal duration .", "sentence_id": 13}
+{"abstract_id": "25168853", "label": "conclusions", "text": "They will also inform the feasibility and potential benefit of an alternative mind-body breathing intervention , and provide insight regarding how isolated mind-body exercise components contribute to the overall effects of tai chi .", "sentence_id": 14}
+{"abstract_id": "25168853", "label": "conclusions", "text": "Should the results be positive , tai chi and related mind-body practices may offer a novel exercise option that is potentially accessible to a large proportion of patients with COPD .", "sentence_id": 15}
+{"abstract_id": "25347723", "label": "objective", "text": "To determine whether a pharmacist-led medications review in primary care reduces the number of drugs and the number of drug-related problems .", "sentence_id": 0}
+{"abstract_id": "25347723", "label": "methods", "text": "Prospective randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25347723", "label": "methods", "text": "Liljeholmen Primary Care Centre , Stockholm , Sweden .", "sentence_id": 2}
+{"abstract_id": "25347723", "label": "methods", "text": "@ patients aged @ years with five or more different medications .", "sentence_id": 3}
+{"abstract_id": "25347723", "label": "methods", "text": "Intervention .", "sentence_id": 4}
+{"abstract_id": "25347723", "label": "methods", "text": "Patients answered a questionnaire regarding medications .", "sentence_id": 5}
+{"abstract_id": "25347723", "label": "methods", "text": "The pharmacist reviewed all medications ( prescription , non-prescription , and herbal ) regarding recommendations and renal impairment , giving advice to patients and GPs .", "sentence_id": 6}
+{"abstract_id": "25347723", "label": "methods", "text": "Each patient met the pharmacist before seeing their GP .", "sentence_id": 7}
+{"abstract_id": "25347723", "label": "methods", "text": "Control patients received their usual care .", "sentence_id": 8}
+{"abstract_id": "25347723", "label": "methods", "text": "Drug-related problems and number of drugs .", "sentence_id": 9}
+{"abstract_id": "25347723", "label": "methods", "text": "Secondary outcomes included health care utilization and self-rated health during @ months of follow-up .", "sentence_id": 10}
+{"abstract_id": "25347723", "label": "results", "text": "No significant difference was seen when comparing change in drug-related problems between the groups .", "sentence_id": 11}
+{"abstract_id": "25347723", "label": "results", "text": "However , a significant decrease in drug-related problems was observed in the intervention group ( from @ per patient at baseline to @ at follow-up , p < @ ) .", "sentence_id": 12}
+{"abstract_id": "25347723", "label": "results", "text": "The change in number of drugs was more pronounced in the intervention group ( p < @ ) .", "sentence_id": 13}
+{"abstract_id": "25347723", "label": "results", "text": "Intervention group patients were not admitted to hospital on fewer occasions or for fewer days , and there was no significant difference between the two groups regarding utilization of primary care during follow-up .", "sentence_id": 14}
+{"abstract_id": "25347723", "label": "results", "text": "Self-rated health remained unchanged in the intervention group , whereas a drop ( p < @ ) was reported in the control group .", "sentence_id": 15}
+{"abstract_id": "25347723", "label": "results", "text": "This resulted in a significant difference in change in self-rated health between the groups ( p < @ ) .", "sentence_id": 16}
+{"abstract_id": "25347723", "label": "conclusions", "text": "The addition of a skilled pharmacist to the primary care team may contribute to reductions in numbers of drugs and maintenance of self-rated health in elderly patients with polypharmacy .", "sentence_id": 17}
+{"abstract_id": "26028283", "label": "objective", "text": "Exercise evokes pulsatile GH release followed by autonegative feedback , whereas glucose suppresses GH release followed by rebound-like GH release ( feedforward escape ) .", "sentence_id": 0}
+{"abstract_id": "26028283", "label": "objective", "text": "Here we test the hypothesis that age , sex steroids , insulin , body composition and physical power jointly determine these dynamic GH responses .", "sentence_id": 1}
+{"abstract_id": "26028283", "label": "methods", "text": "This was a prospectively randomized glucose-blinded study conducted in the Mayo Center for Advancing Translational Sciences in healthy men ages @-@ years ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "26028283", "label": "methods", "text": "Three conditions , fasting/rest/saline , fasting/exercise/saline and fasting/rest/iv glucose infusions , were used to drive GH dynamics during @-min blood sampling for @h .", "sentence_id": 3}
+{"abstract_id": "26028283", "label": "methods", "text": "Linear correlation analysis was applied to relate peak/nadir GH dynamics to age , sex steroids , insulin , CT-estimated abdominal fat and physical power ( work per unit time ) .", "sentence_id": 4}
+{"abstract_id": "26028283", "label": "results", "text": "Compared with the fasting/rest/saline ( control ) day , fasting/exercise/saline infusion evoked peak GH within @h , followed by negative feedback @-@h later .", "sentence_id": 5}
+{"abstract_id": "26028283", "label": "results", "text": "The dynamic GH excursion was strongly ( R ( @ ) = @ ) influenced by ( i ) insulin negatively ( P = @ ) , ( ii ) power positively ( P = @ ) , and ( iii ) E@ positively ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26028283", "label": "results", "text": "Dynamic glucose-modulated GH release was determined by insulin negatively ( P = @ ) and power positively ( P = @ ) ( R ( @ ) = @ ) .", "sentence_id": 7}
+{"abstract_id": "26028283", "label": "results", "text": "Under rest/saline , power ( P = @ ) and total abdominal fat ( P = @ ) ( R ( @ ) = @ ) were the dominant correlates of GH excursions .", "sentence_id": 8}
+{"abstract_id": "26028283", "label": "conclusions", "text": "In healthy men , dynamic GH perturbations induced by exercise and glucose are strongly related to physical power , insulin , estradiol , and body composition , thus suggesting a network of regulatory pathways .", "sentence_id": 9}
+{"abstract_id": "25533727", "label": "background", "text": "Observational evidence from behavioral weight control trials and community studies suggests that greater frequency of weighing oneself , or tracking weight , is associated with better weight outcomes .", "sentence_id": 0}
+{"abstract_id": "25533727", "label": "background", "text": "Conversely , it has also been suggested that frequent weight tracking may have a negative impact on mental health and outcomes during weight loss , but there are minimal experimental data that address this concern in the context of an active weight loss program .", "sentence_id": 1}
+{"abstract_id": "25533727", "label": "background", "text": "To achieve the long-term goal of strengthening behavioral weight loss programs , the purpose of this randomized controlled trial ( the Tracking Study ) is to test variations on frequency of self-weighing during a behavioral weight loss program , and to examine psychosocial and mental health correlates of weight tracking and weight loss outcomes .", "sentence_id": 2}
+{"abstract_id": "25533727", "label": "background", "text": "This paper describes the study design , intervention features , recruitment , and baseline characteristics of participants enrolled in the Tracking Study .", "sentence_id": 3}
+{"abstract_id": "25533727", "label": "methods", "text": "Three hundred thirty-nine overweight and obese adults were recruited and randomized to one of three variations on weight tracking frequency during a @-month weight loss program with a @-month follow-up : daily weight tracking , weekly weight tracking , or no weight tracking .", "sentence_id": 4}
+{"abstract_id": "25533727", "label": "methods", "text": "The primary outcome is weight in kilograms at @ months .", "sentence_id": 5}
+{"abstract_id": "25533727", "label": "methods", "text": "The weight loss program integrates each weight tracking instruction with standard behavioral weight loss techniques ( goal setting , self-monitoring , stimulus control , dietary and physical activity enhancements , lifestyle modifications ) ; participants in weight tracking conditions were provided with wireless Internet technology ( wi-fi-enabled digital scales and touchscreen personal devices ) to facilitate weight tracking during the study .", "sentence_id": 6}
+{"abstract_id": "25533727", "label": "conclusions", "text": "This study was successful in recruiting adult male and female participants and is positioned to enhance the standard of care with regard to weight tracking recommendations .", "sentence_id": 7}
+{"abstract_id": "25042759", "label": "background", "text": "This Stage II trial builds on a Stage I trial comparing the single-gender Women 's Recovery Group ( WRG ) to mixed-gender Group Drug Counseling ( GDC ) that demonstrated preliminary support for the WRG in treating women with substance use disorders .", "sentence_id": 0}
+{"abstract_id": "25042759", "label": "background", "text": "The Stage II trial aims were to ( @ ) investigate effectiveness of the WRG relative to GDC in a sample of women heterogeneous with respect to substance of abuse and co-occurring psychiatric disorders , and ( @ ) demonstrate the feasibility of implementing WRG in an open-enrollment group format at two sites .", "sentence_id": 1}
+{"abstract_id": "25042759", "label": "methods", "text": "In this randomized clinical trial , participants were included if they were substance dependent and had used substances within the past @ days ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25042759", "label": "methods", "text": "Women were randomized to WRG ( n = @ ) or GDC ( n = @ ) ; men were assigned to GDC ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25042759", "label": "methods", "text": "Substance use outcomes were assessed at months @-@ and @ .", "sentence_id": 4}
+{"abstract_id": "25042759", "label": "results", "text": "Women in both the WRG and GDC had reductions in mean number of substance use days during treatment ( @ vs @ day reductions for WRG and GDC , respectively ) and @ months post-treatment ( @ vs @ day reductions ) ; however , there were no significant differences between groups .", "sentence_id": 5}
+{"abstract_id": "25042759", "label": "conclusions", "text": "The WRG demonstrated comparable effectiveness to standard mixed-gender treatment ( i.e. , GDC ) and is feasibly delivered in an open-group format typical of community treatment .", "sentence_id": 6}
+{"abstract_id": "25042759", "label": "conclusions", "text": "It provides a manual-based group therapy with women-focused content that can be implemented in a variety of clinical settings for women who are heterogeneous with respect to their substance of abuse , other co-occurring psychiatric disorders , and life-stage .", "sentence_id": 7}
+{"abstract_id": "25544294", "label": "objective", "text": "Recently , attention has been paid to dexmedetomidine , a selective -@ adrenoceptor agonist , as a possible additive for local anesthesia .", "sentence_id": 0}
+{"abstract_id": "25544294", "label": "objective", "text": "However , the effect of locally injected dexmedetomidine on the anesthetic action in humans has not fully been clarified .", "sentence_id": 1}
+{"abstract_id": "25544294", "label": "objective", "text": "Thus , the purpose of the present study was to evaluate the effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans .", "sentence_id": 2}
+{"abstract_id": "25544294", "label": "methods", "text": "Twenty healthy volunteers were included in the present crossover double-blinded study .", "sentence_id": 3}
+{"abstract_id": "25544294", "label": "methods", "text": "Lidocaine solution or lidocaine plus dexmedetomidine solution was submucosally injected into the alveolar mucosa in a crossover and double-blinded manner .", "sentence_id": 4}
+{"abstract_id": "25544294", "label": "methods", "text": "The local anesthetic effect of the solutions was evaluated by measuring the current perception threshold ( CPT ) in the oral mucosa for @ minutes after injection .", "sentence_id": 5}
+{"abstract_id": "25544294", "label": "methods", "text": "Furthermore , the sedation level , blood pressure , and heart rate of the volunteers were evaluated .", "sentence_id": 6}
+{"abstract_id": "25544294", "label": "methods", "text": "For statistical analysis , the Wilcoxon signed rank test and @-way repeated measures analysis of variation were used .", "sentence_id": 7}
+{"abstract_id": "25544294", "label": "results", "text": "The CPT was increased with the @ solutions and peaked @ minutes after injection .", "sentence_id": 8}
+{"abstract_id": "25544294", "label": "results", "text": "CPT values @ and @ minutes after injection of lidocaine plus dexmedetomidine solution were considerably higher than those with lidocaine solution .", "sentence_id": 9}
+{"abstract_id": "25544294", "label": "results", "text": "The duration of an important increase in the CPT after injection with lidocaine plus dexmedetomidine solution was longer than that with lidocaine .", "sentence_id": 10}
+{"abstract_id": "25544294", "label": "results", "text": "Furthermore , the area under the time curve of CPT was considerably higher with lidocaine plus dexmedetomidine solution than with lidocaine solution .", "sentence_id": 11}
+{"abstract_id": "25544294", "label": "results", "text": "No volunteer showed a change in sedation level , blood pressure , or heart rate after injection with either test solution throughout the experiment .", "sentence_id": 12}
+{"abstract_id": "25544294", "label": "conclusions", "text": "The present study showed that a combination of dexmedetomidine plus lidocaine considerably enhances the local anesthetic potency of lidocaine without any major influences on the cardiovascular system when locally injected into the oral mucosa .", "sentence_id": 13}
+{"abstract_id": "25877784", "label": "background", "text": "The purpose of this study was to determine the efficacy of a clinician referral and exercise program in improving exercise levels and quality of life for men with prostate cancer .", "sentence_id": 0}
+{"abstract_id": "25877784", "label": "methods", "text": "This was a multicenter cluster randomized controlled trial in Melbourne , Australia comprising @ clinicians : @ clinicians were randomized to refer eligible participants ( n = @ ) to a @-week exercise program comprising @ supervised gym sessions and @ home-based session per week , and @ clinicians were randomized to follow usual care ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25877784", "label": "methods", "text": "The primary outcome was self-reported physical activity ; the secondary outcomes were quality of life , anxiety , and symptoms of depression .", "sentence_id": 2}
+{"abstract_id": "25877784", "label": "results", "text": "A significant intervention effect was observed for vigorous-intensity exercise ( effect size : Cohen 's d , @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ; P = @ ) but not for combined moderate and vigorous exercise levels ( effect size : d , @ ; @ % CI , -@ to @ ; P = @ ) .", "sentence_id": 3}
+{"abstract_id": "25877784", "label": "results", "text": "Significant intervention effects were also observed for meeting exercise guidelines ( @ min/wk ; odds ratio , @ ; @ % CI , @-@ @ ; P = @ ) ; positive intervention effects were observed in the intervention group for cognitive functioning ( effect size : d , @ ; @ % CI , -@ to @ ; P = @ ) and depression symptoms ( effect size : d , -@ ; @ % CI , -@ to @ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25877784", "label": "results", "text": "Eighty percent of participants reported that the clinician 's referral influenced their decision to participate in the exercise program .", "sentence_id": 5}
+{"abstract_id": "25877784", "label": "conclusions", "text": "The clinician referral and @-week exercise program significantly improved vigorous exercise levels and had a positive impact on mental health outcomes for men living with prostate cancer .", "sentence_id": 6}
+{"abstract_id": "25877784", "label": "conclusions", "text": "Further research is needed to determine the sustainability of the exercise program and its generalizability to other cancer populations .", "sentence_id": 7}
+{"abstract_id": "25083980", "label": "objective", "text": "To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger , pyridoxalated hemoglobin polyoxyethylene , against placebo in patients with vasopressor-dependent distributive shock .", "sentence_id": 0}
+{"abstract_id": "25083980", "label": "methods", "text": "Multicenter , randomized , placebo-controlled , open-label study .", "sentence_id": 1}
+{"abstract_id": "25083980", "label": "methods", "text": "Sixty-one participating ICUs in six European countries ( Austria , Belgium , Germany , the Netherlands , Spain , and United Kingdom ) .", "sentence_id": 2}
+{"abstract_id": "25083980", "label": "methods", "text": "All patients admitted with distributive shock , defined as the presence of at least two systemic inflammatory response syndrome criteria , persisting norepinephrine dependence and evidence of organ dysfunction/hypoperfusion despite adequate fluid resuscitation .", "sentence_id": 3}
+{"abstract_id": "25083980", "label": "methods", "text": "Patients were randomized to receive @ mL/kg/hr pyridoxalated hemoglobin polyoxyethylene ( @ mg Hb/kg/hr ) or an equal volume of placebo , infused for up to @ hours , in addition to conventional vasopressor therapy .", "sentence_id": 4}
+{"abstract_id": "25083980", "label": "results", "text": "The study was stopped after interim analysis showed higher mortality in the pyridoxalated hemoglobin polyoxyethylene group and an increased prevalence of adverse events .", "sentence_id": 5}
+{"abstract_id": "25083980", "label": "results", "text": "At this time , @ patients had been randomized to pyridoxalated hemoglobin polyoxyethylene ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "25083980", "label": "results", "text": "Age , gender , type of patient ( medical/surgical ) , and Acute Physiology and Chronic Health Evaluation II scores were similar between groups .", "sentence_id": 7}
+{"abstract_id": "25083980", "label": "results", "text": "Twenty-eight-day mortality rate was @ % in the pyridoxalated hemoglobin polyoxyethylene group versus @ % in the placebo group ( OR , @ ; @ % CI , @-@ @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25083980", "label": "results", "text": "In patients with higher organ dysfunction scores ( Sepsis-related Organ Failure Assessment > @ ) , mortality rates were significantly higher in the pyridoxalated hemoglobin polyoxyethylene group when compared with those in placebo-treated patients ( @ % vs @ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25083980", "label": "results", "text": "Survivors who received pyridoxalated hemoglobin polyoxyethylene had a longer vasopressor-free time ( @ vs @ d ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25083980", "label": "conclusions", "text": "In this randomized , controlled phase III trial in patients with vasopressor-dependent distributive shock , administration of a pyridoxalated hemoglobin solution decreased the need for vasopressors but was associated with a trend to increased mortality .", "sentence_id": 11}
+{"abstract_id": "25227824", "label": "background", "text": "Few Iranian women take the Papanicolaou test despite its important role in preventing cervical cancer .", "sentence_id": 0}
+{"abstract_id": "25227824", "label": "background", "text": "This study aimed to determine the effectiveness of an educational intervention based on the protection motivation theory ( PMT ) variables and implementation intentions in the first and second Pap test practice among Iranian women .", "sentence_id": 1}
+{"abstract_id": "25227824", "label": "methods", "text": "In this quasi-randomized controlled trial , @ women who were referred to @ primary health care clinics in Tehran were randomly selected .", "sentence_id": 2}
+{"abstract_id": "25227824", "label": "methods", "text": "PMT variables and Pap test practice were measured at baseline and again after @ and @ months .", "sentence_id": 3}
+{"abstract_id": "25227824", "label": "methods", "text": "The @-week educational intervention program was conducted for the intervention group .", "sentence_id": 4}
+{"abstract_id": "25227824", "label": "results", "text": "Following the intervention , the mean scores of self-efficacy , perceived vulnerability , and behavior intention variables were significantly higher in the intervention group when compared to the control group ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25227824", "label": "results", "text": "No significant differences were found in the perceived severity , response efficacy , response cost , and fear between the two groups following the intervention .", "sentence_id": 6}
+{"abstract_id": "25227824", "label": "results", "text": "Higher percent of women in the intervention group had obtained first and second Pap test compared to the controls .", "sentence_id": 7}
+{"abstract_id": "25227824", "label": "conclusions", "text": "The PMT and implementation intentions provide a suitable theory-based framework for developing educational interventions regarding Pap test practice in Iran .", "sentence_id": 8}
+{"abstract_id": "25401779", "label": "background", "text": "Pelvic floor muscle training ( PFMT ) has level @ evidence of reducing the size and symptoms associated with pelvic organ prolapse ( POP ) .", "sentence_id": 0}
+{"abstract_id": "25401779", "label": "background", "text": "There is scant knowledge , however , regarding whether PFMT has an effect on sexual function .", "sentence_id": 1}
+{"abstract_id": "25401779", "label": "objective", "text": "The aim of the trial was to evaluate the effect of PFMT on sexual function in women with POP .", "sentence_id": 2}
+{"abstract_id": "25401779", "label": "methods", "text": "In this randomized controlled trial , @ women were randomized to an intervention group ( @ months of PFMT and lifestyle advice ) and @ women were randomized to a control group ( lifestyle advice only ) .", "sentence_id": 3}
+{"abstract_id": "25401779", "label": "methods", "text": "Participants completed a validated POP-specific questionnaire to describe frequency and bother of prolapse , bladder , bowel , and sexual symptoms and answered a semi-structured interview .", "sentence_id": 4}
+{"abstract_id": "25401779", "label": "results", "text": "No significant change in number of women being sexually active was reported .", "sentence_id": 5}
+{"abstract_id": "25401779", "label": "results", "text": "There were no significant differences between groups regarding change in satisfaction with frequency of intercourse .", "sentence_id": 6}
+{"abstract_id": "25401779", "label": "results", "text": "Interview data revealed that @ ( @ % ) of women in the PFMT group experienced improved sexual function vs. two ( @ % ) in the control group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25401779", "label": "results", "text": "Specific improvements reported by some of the women were increased control , strength and awareness of the pelvic floor , improved self-confidence , sensation of a `` tighter '' vagina , improved libido and orgasms , resolution of pain with intercourse , and heightened sexual gratification for partners .", "sentence_id": 8}
+{"abstract_id": "25401779", "label": "results", "text": "Women who described improved sexual function demonstrated the greatest increases in pelvic floor muscle ( PFM ) strength ( mean @ @ cmH@ @ ) and endurance ( mean @ @ cmH@ @s ) ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25401779", "label": "conclusions", "text": "PFMT can improve sexual function in some women .", "sentence_id": 10}
+{"abstract_id": "25401779", "label": "conclusions", "text": "Women reporting improvement in sexual function demonstrated the greatest increase in PFM strength and endurance .", "sentence_id": 11}
+{"abstract_id": "25270758", "label": "objective", "text": "Service user satisfaction with therapy is a key part of the therapeutic process .", "sentence_id": 0}
+{"abstract_id": "25270758", "label": "objective", "text": "The aim of this study was to investigate service user experiences of an @-week group positive psychology intervention for psychosis ( WELLFOCUS PPT ) in the context of a randomized controlled trial ( ISRCTN@ ) .", "sentence_id": 1}
+{"abstract_id": "25270758", "label": "methods", "text": "Participants were @ individuals ( @ % male ; mean age @ years ) receiving the intervention as part of the trial .", "sentence_id": 2}
+{"abstract_id": "25270758", "label": "methods", "text": "Semistructured interviews and focus groups were conducted to investigate participants ' views of WELLFOCUS PPT .", "sentence_id": 3}
+{"abstract_id": "25270758", "label": "methods", "text": "Transcripts were analyzed both deductively and inductively to identify common themes .", "sentence_id": 4}
+{"abstract_id": "25270758", "label": "results", "text": "Feedback about the group experience was positive throughout .", "sentence_id": 5}
+{"abstract_id": "25270758", "label": "results", "text": "Components found helpful included learning to savor experiences , identifying and developing strengths , forgiveness , gratitude , and therapist self-disclosure .", "sentence_id": 6}
+{"abstract_id": "25270758", "label": "conclusions", "text": "Findings emphasize the importance of considering service users ' perceptions of therapy and can be used to guide clinicians in deciding whether to include one or more of the components of WELLFOCUS PPT in therapy .", "sentence_id": 7}
+{"abstract_id": "25079934", "label": "objective", "text": "To determine the effectiveness of a single perioperative prophylactic @g dose of cephalexin in preventing surgical site infection ( SSI ) following excision of skin lesions from the lower limb .", "sentence_id": 0}
+{"abstract_id": "25079934", "label": "methods", "text": "Prospective double-blinded placebo-controlled trial testing for difference in infection rates .", "sentence_id": 1}
+{"abstract_id": "25079934", "label": "methods", "text": "Primary care in regional North Queensland , Australia .", "sentence_id": 2}
+{"abstract_id": "25079934", "label": "methods", "text": "@ patients undergoing lower limb skin lesion excision .", "sentence_id": 3}
+{"abstract_id": "25079934", "label": "methods", "text": "@g dose of cephalexin @-@min before excision .", "sentence_id": 4}
+{"abstract_id": "25079934", "label": "methods", "text": "Incidence of SSI .", "sentence_id": 5}
+{"abstract_id": "25079934", "label": "results", "text": "Incidence of SSI was @ % ( @ % CI @ % to @ % ) in the cephalexin group compared with @ % ( @ % CI @ % to @ % ) in the placebo group ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25079934", "label": "results", "text": "This represented an absolute reduction of @ % ( @ % CI -@ % to @ % ) , relative reduction of @ % ( @ % CI -@ % to @ % ) and number-needed-to-treat of @ .", "sentence_id": 7}
+{"abstract_id": "25079934", "label": "conclusions", "text": "Administration of a single @g dose of cephalexin @-@min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection ; however , this study was underpowered to statistically determine this .", "sentence_id": 8}
+{"abstract_id": "25042199", "label": "background", "text": "Multicentric Castleman 's disease is a rare lymphoproliferative disorder driven by dysregulated production of interleukin @ .", "sentence_id": 0}
+{"abstract_id": "25042199", "label": "background", "text": "No randomised trials have been done to establish the best treatment for the disease .", "sentence_id": 1}
+{"abstract_id": "25042199", "label": "background", "text": "We assessed the safety and efficacy of siltuximab-a chimeric monoclonal antibody against interleukin @-in HIV-negative patients with multicentric Castleman 's disease .", "sentence_id": 2}
+{"abstract_id": "25042199", "label": "methods", "text": "We did this randomised , double-blind , placebo-controlled study at @ hospitals in @ countries worldwide .", "sentence_id": 3}
+{"abstract_id": "25042199", "label": "methods", "text": "We enrolled HIV-negative and human herpesvirus-@-seronegative patients with symptomatic multicentric Castleman 's disease .", "sentence_id": 4}
+{"abstract_id": "25042199", "label": "methods", "text": "Treatment allocation was randomised with a computer-generated list , with block size six , and stratification by baseline corticosteroid use .", "sentence_id": 5}
+{"abstract_id": "25042199", "label": "methods", "text": "Patients and investigators were masked to treatment allocation .", "sentence_id": 6}
+{"abstract_id": "25042199", "label": "methods", "text": "Patients were randomly assigned ( @:@ ) to siltuximab ( @ mg/kg intravenous infusion every @ weeks ) or placebo ; all patients also received best supportive care .", "sentence_id": 7}
+{"abstract_id": "25042199", "label": "methods", "text": "Patients continued treatment until treatment failure .", "sentence_id": 8}
+{"abstract_id": "25042199", "label": "methods", "text": "The primary endpoint was durable tumour and symptomatic response for at least @ weeks for the intention-to-treat population .", "sentence_id": 9}
+{"abstract_id": "25042199", "label": "methods", "text": "Enrolment has been completed .", "sentence_id": 10}
+{"abstract_id": "25042199", "label": "methods", "text": "The study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 11}
+{"abstract_id": "25042199", "label": "results", "text": "We screened @ patients , @ of whom were randomly assigned to siltuximab ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 12}
+{"abstract_id": "25042199", "label": "results", "text": "Durable tumour and symptomatic responses occurred in @ ( @ % ) of @ patients in the siltuximab group and none of @ in the placebo group ( difference @ % , @ % CI @-@ , p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25042199", "label": "results", "text": "The incidence of grade @ or more adverse events ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) and serious adverse events ( @ -LSB- @ % -RSB- vs five -LSB- @ % -RSB- ) was similar in each group despite longer median treatment duration with siltuximab than with placebo ( @ days -LSB- range @-@ -RSB- vs @ days -LSB- @-@ -RSB- ) .", "sentence_id": 14}
+{"abstract_id": "25042199", "label": "results", "text": "The most common grade @ or higher were fatigue ( five vs one ) , night sweats ( four vs one ) , and anaemia ( one vs three ) .", "sentence_id": 15}
+{"abstract_id": "25042199", "label": "results", "text": "Three ( @ % ) of @ patients had serious adverse events judged reasonably related to siltuximab ( lower respiratory tract infection , anaphylactic reaction , sepsis ) .", "sentence_id": 16}
+{"abstract_id": "25042199", "label": "conclusions", "text": "Siltuximab plus best supportive care was superior to best supportive care alone for patients with symptomatic multicentric Castleman 's disease and well tolerated with prolonged exposure .", "sentence_id": 17}
+{"abstract_id": "25042199", "label": "conclusions", "text": "Siltuximab is an important new treatment option for this disease .", "sentence_id": 18}
+{"abstract_id": "25490803", "label": "objective", "text": "This article evaluates the effectiveness of two interventions : a self-leveling pallet carousel designed to position the loads vertically and horizontally at origin , and an adjustable cart designed to raise loads vertically at destination to reduce spine loads .", "sentence_id": 0}
+{"abstract_id": "25490803", "label": "background", "text": "Low back disorders among workers in manual material handling industries are very prevalent and have been linked to manual palletizing operations .", "sentence_id": 1}
+{"abstract_id": "25490803", "label": "background", "text": "Evidence into the effectiveness of ergonomic interventions is limited , with no research that investigates interventions with adjustable load location .", "sentence_id": 2}
+{"abstract_id": "25490803", "label": "methods", "text": "Thirteen males experienced in manual material handling participated in simulated order selecting tasks where spine loads were quantified for each intervention condition : carousel to traditional cart , pallet to traditional cart , pallet to adjustable cart , and carousel to adjustable cart .", "sentence_id": 3}
+{"abstract_id": "25490803", "label": "results", "text": "The results showed that combining both devices results in reduction in spine compression ( @ % ) , anterior-posterior shear ( @ % ) , and lateral shear ( @ % ) compared to traditional palletizing conditions .", "sentence_id": 4}
+{"abstract_id": "25490803", "label": "results", "text": "Individually , the carousel was responsible for the greatest reductions , but the lowest values were typically achieved by combining the adjustable cart and carousel .", "sentence_id": 5}
+{"abstract_id": "25490803", "label": "conclusions", "text": "The combination of the interventions ( self-leveling carousel and adjustable cart ) was most effective in reducing the spine loads when compared to the traditional pallet-cart condition .", "sentence_id": 6}
+{"abstract_id": "25490803", "label": "conclusions", "text": "The individual interventions also reduced the loads compared to the traditional condition .", "sentence_id": 7}
+{"abstract_id": "25490803", "label": "conclusions", "text": "With de-palletizing/palletizing tasks being a major source of low back injuries , the combination of self-leveling carousel and adjustable cart has been found to be effective in reducing the peak spine loading as compared to traditional pallet on floor and nonadjustable flat cart conditions .", "sentence_id": 8}
+{"abstract_id": "25089351", "label": "objective", "text": "To determine the influence of omega-@ supplementation on vitreous vascular endothelial growth factor A ( VEGF-A ) levels in patients with exudative age-related macular degeneration ( wet AMD ) receiving intravitreal anti-VEGF treatment .", "sentence_id": 0}
+{"abstract_id": "25089351", "label": "methods", "text": "Prospective , randomized , open-label , single-center , clinical trial , consecutive interventional case series .", "sentence_id": 1}
+{"abstract_id": "25089351", "label": "methods", "text": "The study included @ cohorts with wet AMD and a control group with epiretinal membrane or macular hole .", "sentence_id": 2}
+{"abstract_id": "25089351", "label": "methods", "text": "Twenty wet AMD patients being treated with anti-VEGF were randomized to daily supplementation of antioxidants , zinc , and carotenoids with omega-@ fatty acids ( docosahexaenoic acid and eicosapentaenoic acid ; group @ , n = @ ) or without omega-@ fatty acids ( group @ , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25089351", "label": "methods", "text": "They were compared with an anti-VEGF treatment-nave wet AMD group ( group @ , n = @ ) and an epiretinal membrane or macular hole group ( group @ , n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25089351", "label": "methods", "text": "Primary outcome was vitreal VEGF-A levels ( at the time of anti-VEGF injection ) .", "sentence_id": 5}
+{"abstract_id": "25089351", "label": "methods", "text": "Secondary outcomes were plasma VEGF-A and central foveal thickness .", "sentence_id": 6}
+{"abstract_id": "25089351", "label": "methods", "text": "Patients with new submacular hemorrhage or any other treatment within @ months were excluded .", "sentence_id": 7}
+{"abstract_id": "25089351", "label": "methods", "text": "Final analyses included @ , @ , @ , and @ patients in groups @ through @ , respectively .", "sentence_id": 8}
+{"abstract_id": "25089351", "label": "results", "text": "Patients receiving omega-@s ( group @ ) had significantly lower levels of vitreal VEGF-A ( @ @ pg/mL ) when compared with group @ ( @ @ pg/mL ; P = @ ) and group @ ( @ @ pg/mL ; P = @ ) , but similar levels to group @ ( @ @ pg/mL ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25089351", "label": "results", "text": "All groups showed similar values for plasma VEGF-A and central foveal thickness measurements .", "sentence_id": 10}
+{"abstract_id": "25089351", "label": "conclusions", "text": "This study demonstrated that omega-@ supplementation combined with anti-VEGF treatment is associated with decreased vitreal VEGF-A levels in wet AMD patients .", "sentence_id": 11}
+{"abstract_id": "24748529", "label": "objective", "text": "Exercise at @-@ % of peak oxygen consumption ( VO@ peak ) stimulates maximal fat oxidation rates .", "sentence_id": 0}
+{"abstract_id": "24748529", "label": "objective", "text": "Despite a lower estimated work performed ; high-intensity intermittent exercise ( HIIE ) training produces greater fat mass reductions when compared with workload-matched continuous ( CON ) steady state exercise .", "sentence_id": 1}
+{"abstract_id": "24748529", "label": "objective", "text": "No metabolic basis has been documented nor mechanisms offered to explain this anomaly .", "sentence_id": 2}
+{"abstract_id": "24748529", "label": "objective", "text": "This study investigated the physiological and metabolic responses of two different workload-matched exercise protocols .", "sentence_id": 3}
+{"abstract_id": "24748529", "label": "methods", "text": "On separate occasions and at least @week apart , eight apparently healthy males cycled for @min at either @ % VO@ peak ( CON ) or performed repeated @s bouts of supramaximal exercise at @ % VO@ peak separated by @s rest ( HIIE ) .", "sentence_id": 4}
+{"abstract_id": "24748529", "label": "results", "text": "The average heart rate , oxygen consumption , plasma glycerol and free fatty acid concentrations were not different during exercise and recovery between the trials .", "sentence_id": 5}
+{"abstract_id": "24748529", "label": "results", "text": "Plasma lactate and hypoxanthine ( Hx ) concentrations were elevated and urinary excretion rates of Hx and uric acid were greater following HIIE as compared to CON ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24748529", "label": "conclusions", "text": "Exercise-induced plasma Hx accumulation and urinary purine excretion are greater following HIIE and indirectly represents a net loss of adenosine triphosphate ( ATP ) from the muscle .", "sentence_id": 7}
+{"abstract_id": "24748529", "label": "conclusions", "text": "The subsequent restorative processes required for intramuscular de novo replacement of ATP may contribute to a negative energy balance and in part , account for the potential accelerated fat loss observed with HIIE when compared with CON training programs .", "sentence_id": 8}
+{"abstract_id": "25054648", "label": "methods", "text": "Single blinded , randomized clinical trial for the evaluation of lumbosacral orthoses ( LSOs ) in the management of lower back pain ( LBP ) .", "sentence_id": 0}
+{"abstract_id": "25054648", "label": "objective", "text": "To evaluate the effects of two types of LSOs on self-rated disability in patients with LBP .", "sentence_id": 1}
+{"abstract_id": "25054648", "label": "background", "text": "LSOs are commonly used for the management of LBP , but their effectiveness may vary because of design .", "sentence_id": 2}
+{"abstract_id": "25054648", "label": "background", "text": "An inextensible LSO ( iLSO ) reduces trunk motion and increases trunk stiffness , whereas an extensible LSO ( eLSO ) does not .", "sentence_id": 3}
+{"abstract_id": "25054648", "label": "methods", "text": "A total of @ participants with LBP were randomized to @ groups : ( @ ) standard care ( SC ) group , which included medication and physical therapy ( n = @ ) , ( @ ) SC with eLSO ( eLSO group ) ( n = @ ) , and ( @ ) SC with iLSO ( iLSO group ) ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25054648", "label": "methods", "text": "Outcome measures were evaluated before and after @ weeks of treatment : modified Oswestry Disability Index ( ODI ) , Patient Specific Activity Scale , pain ratings , and Fear Avoidance Beliefs Questionnaire .", "sentence_id": 5}
+{"abstract_id": "25054648", "label": "results", "text": "There were no statistically significant differences between groups at baseline .", "sentence_id": 6}
+{"abstract_id": "25054648", "label": "results", "text": "Compared with the SC alone , iLSO group showed greater improvement on the ODI scores ( P = @ ) but not the eLSO group .", "sentence_id": 7}
+{"abstract_id": "25054648", "label": "results", "text": "The ODI scores improved by a mean of @ ( @ % confidence interval -LSB- CI -RSB- , @-@ @ ) , @ ( @ % CI , @-@ @ ) , and @ ( @ % CI , @-@ @ ) points for SC , eLSO , and iLSO groups , respectively .", "sentence_id": 8}
+{"abstract_id": "25054648", "label": "results", "text": "Individuals wearing the iLSO had @ times higher odds of achieving @ % or greater improvement in the ODI scores than those assigned to SC ( @ % CI , @-@ @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25054648", "label": "results", "text": "Both the eLSO and iLSO groups had a greater improvement in the Patient Specific Activity Scale scores than the SC group ( P = @ and P = @ , respectively ) , but the change did not meet the minimal clinically important difference .", "sentence_id": 10}
+{"abstract_id": "25054648", "label": "results", "text": "Pain ratings improved for all @ groups , with no statistical difference between them .", "sentence_id": 11}
+{"abstract_id": "25054648", "label": "results", "text": "Finally , no significant differences across groups were found for the Fear Avoidance Beliefs Questionnaire .", "sentence_id": 12}
+{"abstract_id": "25054648", "label": "conclusions", "text": "An iLSO led to greater improvement in ODI scores than SC and an eLSO .", "sentence_id": 13}
+{"abstract_id": "25054648", "label": "conclusions", "text": "We surmise that the likely mechanism responsible for this difference in outcome was the added trunk stiffness and motion restriction by the iLSO .", "sentence_id": 14}
+{"abstract_id": "26072109", "label": "background", "text": "Ixekizumab is a humanised monoclonal antibody against the proinflammatory cytokine interleukin @A .", "sentence_id": 0}
+{"abstract_id": "26072109", "label": "background", "text": "We report two studies of ixekizumab compared with placebo or etanercept to assess the safety and efficacy of specifically targeting interleukin @A in patients with widespread moderate-to-severe psoriasis .", "sentence_id": 1}
+{"abstract_id": "26072109", "label": "methods", "text": "In two prospective , double-blind , multicentre , phase @ studies ( UNCOVER-@ and UNCOVER-@ ) , eligible patients were aged @ years or older , had a confirmed diagnosis of chronic plaque psoriasis at least @ months before baseline ( randomisation ) , @ % or greater body-surface area involvement at both screening and baseline visits , at least a moderate clinical severity as measured by a static physician global assessment ( sPGA ) score of @ or more , and a psoriasis area and severity index ( PASI ) score of @ .", "sentence_id": 2}
+{"abstract_id": "26072109", "label": "methods", "text": "Participants were randomly assigned ( @:@:@:@ ) by computer-generated random sequence with an interactive voice response system to receive subcutaneous placebo , etanercept ( @ mg twice weekly ) , or one injection of @ mg ixekizumab every @ weeks , or every @ weeks after a @ mg starting dose .", "sentence_id": 3}
+{"abstract_id": "26072109", "label": "methods", "text": "Blinding was maintained with a double-dummy design .", "sentence_id": 4}
+{"abstract_id": "26072109", "label": "methods", "text": "Coprimary efficacy endpoints were proportions of patients achieving sPGA score @ or @ and @ % or greater improvement in PASI at week @ .", "sentence_id": 5}
+{"abstract_id": "26072109", "label": "methods", "text": "Analysis was by intention to treat .", "sentence_id": 6}
+{"abstract_id": "26072109", "label": "methods", "text": "These trials are registered with ClinicalTrials.gov , numbers NCT@ and NCT@ .", "sentence_id": 7}
+{"abstract_id": "26072109", "label": "results", "text": "Between May @ , @ , and Dec @ , @ , @ patients in UNCOVER-@ were randomly assigned to receive subcutaneous placebo ( n = @ ) , etanercept ( n = @ ) , or ixekizumab every @ weeks ( n = @ ) or every @ weeks ( n = @ ) ; between Aug @ , @ , and Feb @ , @ , @ patients in UNCOVER-@ were randomly assigned to receive placebo ( n = @ ) , etanercept ( n = @ ) , ixekizumab every @ weeks ( n = @ ) , or ixekizumab every @ weeks ( n = @ ) .", "sentence_id": 8}
+{"abstract_id": "26072109", "label": "results", "text": "At week @ , both primary endpoints were met in both studies .", "sentence_id": 9}
+{"abstract_id": "26072109", "label": "results", "text": "For UNCOVER-@ and UNCOVER-@ respectively , in the ixekizumab every @ weeks group , PASI @ was achieved by @ ( response rate @ % ; -LSB- effect size @ % ( @ % CI @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) and @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) patients ; in the ixekizumab every @ weeks group , by @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) and @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) patients ; in the placebo group , by four ( @ % ) and @ ( @ % ) patients ; and in the etanercept group by @ ( @ % ) and @ ( @ % ) patients ( all p < @ vs placebo or etanercept ) .", "sentence_id": 10}
+{"abstract_id": "26072109", "label": "results", "text": "In the ixekizumab every @ weeks group , sPGA @/@ was achieved by @ ( response rate @ % ; -LSB- effect size @ % ( @ % CI @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) and @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) patients ; in the ixekizumab every @ weeks group by @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) and @ ( @ % ; -LSB- @ % ( @-@ ) vs placebo ; @ % ( @-@ ) vs etanercept -RSB- ) patients ; in the placebo group by four ( @ % ) and @ ( @ % ) patients ; and in the etanercept group by @ ( @ % ) and @ ( @ % ) patients ( all p < @ vs placebo or etanercept ) .", "sentence_id": 11}
+{"abstract_id": "26072109", "label": "results", "text": "In combined studies , serious adverse events were reported in @ ( @ % ) of @ patients given ixekizumab every @ weeks , @ ( @ % ) of @ given ixekizumab every @ weeks , seven ( @ % ) of @ given placebo , and @ ( @ % ) of @ given etanercept ; no deaths were noted .", "sentence_id": 12}
+{"abstract_id": "26072109", "label": "conclusions", "text": "Both ixekizumab dose regimens had greater efficacy than placebo and etanercept over @ weeks in two independent studies .", "sentence_id": 13}
+{"abstract_id": "26072109", "label": "conclusions", "text": "These studies show that selectively neutralising interleukin @A with a high affinity antibody potentially gives patients with psoriasis a new and effective biological therapy option .", "sentence_id": 14}
+{"abstract_id": "25540035", "label": "background", "text": "Provoked vestibulodynia ( PVD ) , a frequent form of chronic genital pain , is associated with decreased sexual function for afflicted women , as well as impoverished sexual satisfaction for women and their partners .", "sentence_id": 0}
+{"abstract_id": "25540035", "label": "background", "text": "Pain and sexuality outcomes for couples with PVD are influenced by interpersonal factors , such as pain catastrophizing , partner responses to pain , ambivalence over emotional expression , attachment style and perceived relationship and sexual intimacy .", "sentence_id": 1}
+{"abstract_id": "25540035", "label": "background", "text": "Despite recommendations in the literature to include the partner in cognitive-behavioral therapy targeted at improving pain and sexuality outcomes , no randomized clinical trial has tested the efficacy of this type of intervention and compared it to a first-line medical intervention .", "sentence_id": 2}
+{"abstract_id": "25540035", "label": "methods", "text": "This bi-center , randomized clinical trial is designed to examine the efficacy of cognitive-behavioral couple therapy compared to topical lidocaine .", "sentence_id": 3}
+{"abstract_id": "25540035", "label": "methods", "text": "It is conducted across two Canadian university-hospital centers .", "sentence_id": 4}
+{"abstract_id": "25540035", "label": "methods", "text": "Eligible women diagnosed with PVD and their partners are randomized to one of the two interventions .", "sentence_id": 5}
+{"abstract_id": "25540035", "label": "methods", "text": "Evaluations are conducted using structured interviews and validated self-report measures at three time points : Pre-treatment ( T@ : prior to randomization ) , post-treatment ( T@ ) , and @-month follow-up ( T@ ) .", "sentence_id": 6}
+{"abstract_id": "25540035", "label": "methods", "text": "The primary outcome is the change in reported pain during intercourse between T@ and T@ .", "sentence_id": 7}
+{"abstract_id": "25540035", "label": "methods", "text": "Secondary outcomes focus on whether there are significant differences between the two treatments at T@ and T@ on ( a ) the multidimensional aspects of women 's pain and ( b ) women and partners ' sexuality ( sexual function and satisfaction ) , psychological adjustment ( anxiety , depression , catastrophizing , self-efficacy , and quality of life ) , relationship factors ( partner responses and dyadic adjustment ) and self-reported improvement and treatment satisfaction .", "sentence_id": 8}
+{"abstract_id": "25540035", "label": "methods", "text": "In order to detect an effect size as small as @ for secondary outcomes , a sample of @ couples is being recruited ( @ % dropout expected ) .", "sentence_id": 9}
+{"abstract_id": "25540035", "label": "methods", "text": "A clinically significant decrease in pain is defined as a @ % reduction .", "sentence_id": 10}
+{"abstract_id": "25540035", "label": "conclusions", "text": "The randomized clinical trial design is the most appropriate to examine the efficacy of cognitive-behavioral couple therapy , a recently developed and pilot-tested psychosocial intervention for couples coping with PVD , in comparison to a frequent first-line treatment option , topical lidocaine .", "sentence_id": 11}
+{"abstract_id": "25540035", "label": "conclusions", "text": "Findings from this study will provide important information about empirically supported treatment options for PVD , and inform future treatment development and research for this patient population .", "sentence_id": 12}
+{"abstract_id": "24827132", "label": "background", "text": "At @ months of median follow-up , PHARE failed to show that @ was non-inferior to @ months of adjuvant trastuzumab .", "sentence_id": 0}
+{"abstract_id": "24827132", "label": "background", "text": "From the results of PHARE , questions remain regarding whether the magnitude of benefit derived from @ year is sufficient to justify its systematic use for different patient subgroups .", "sentence_id": 1}
+{"abstract_id": "24827132", "label": "methods", "text": "Treatment effects were evaluated according to various tumour characteristics , and the multivariate Cox proportional hazards regression models were carried out on metastases-free survival ( MFS ) in the @ months control arm .", "sentence_id": 2}
+{"abstract_id": "24827132", "label": "methods", "text": "A prognostic score was defined providing the identification of patient categories with similar risks .", "sentence_id": 3}
+{"abstract_id": "24827132", "label": "methods", "text": "The @-month arm was used as a validation set in order to test for heterogeneity .", "sentence_id": 4}
+{"abstract_id": "24827132", "label": "methods", "text": "This study is registered at clinicaltrials.gov , number NCT@ .", "sentence_id": 5}
+{"abstract_id": "24827132", "label": "results", "text": "A total of @ metastatic events were observed and four prognostic groups were defined : very low , low , intermediate and high risk in the @-month arm .", "sentence_id": 6}
+{"abstract_id": "24827132", "label": "results", "text": "The corresponding @-year MFS rates were @ % , @ % , @ % and @ % in the four prognostic groups , respectively .", "sentence_id": 7}
+{"abstract_id": "24827132", "label": "results", "text": "In the @-month arm , the @-year MFS rates were @ % , @ % , @ % and @ % in the four prognostic groups , respectively .", "sentence_id": 8}
+{"abstract_id": "24827132", "label": "conclusions", "text": "In the very low-risk group , the potential absolute benefit of standard duration of trastuzumab was small enough to indicate that optimal standard treatment might be clinically questionable .", "sentence_id": 9}
+{"abstract_id": "24827132", "label": "conclusions", "text": "On the other hand , the @-year metastasis occurrence rates strongly support the need for a search of a more efficient treatment in the low - , intermediate - and high-risk groups .", "sentence_id": 10}
+{"abstract_id": "25847895", "label": "objective", "text": "To compare the outcomes of shock wave lithotripsy ( SWL ) combined with inclined position and SWL alone in patients with lower pole calyx stones .", "sentence_id": 0}
+{"abstract_id": "25847895", "label": "methods", "text": "Seven hundred forty patients who underwent SWL treatment for lower pole renal stones with a total diameter of @ cm or less were prospectively randomized into two groups .", "sentence_id": 1}
+{"abstract_id": "25847895", "label": "methods", "text": "They were comparable in terms of age , sex , and stone diameters .", "sentence_id": 2}
+{"abstract_id": "25847895", "label": "methods", "text": "Patients with lower calyceal stones ( @-@ mm ) were randomized to SWL ( @ patients ) or SWL with simultaneous inclination ( @ patients ) with @o head down Trendelenburg position ) .", "sentence_id": 3}
+{"abstract_id": "25847895", "label": "methods", "text": "Shock wave and session numbers were standardized according to stone size .", "sentence_id": 4}
+{"abstract_id": "25847895", "label": "methods", "text": "Additional standardized shock waves were given to patients with stone fragments determined by kidney urinary bladder film and ultrasound at weeks @ , @ , @ .", "sentence_id": 5}
+{"abstract_id": "25847895", "label": "results", "text": "The overall stone free rate ( SFR ) was @ % ( @/@ ) in patients with SWL alone and @ % ( @/@ ) in SWL with inclination at the end of @th week ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25847895", "label": "results", "text": "No significant adverse events were noted in both treatment groups .", "sentence_id": 7}
+{"abstract_id": "25847895", "label": "conclusions", "text": "Simultaneous inclination of patients during SWL session increase SFR in lower caliceal stones significantly compared to SWL treatment alone .", "sentence_id": 8}
+{"abstract_id": "25715353", "label": "objective", "text": "To study the effects of zinc and steroid in the treatment of traumatic anosmia .", "sentence_id": 0}
+{"abstract_id": "25715353", "label": "methods", "text": "A prospective , randomized study .", "sentence_id": 1}
+{"abstract_id": "25715353", "label": "methods", "text": "Academic medical center .", "sentence_id": 2}
+{"abstract_id": "25715353", "label": "methods", "text": "Patients with a clear history of loss of smell after head injury and whose thresholds were -@ measured by the phenyl ethyl alcohol threshold test were included in this study from January @ to May @ .", "sentence_id": 3}
+{"abstract_id": "25715353", "label": "methods", "text": "They were randomly divided into @ groups .", "sentence_id": 4}
+{"abstract_id": "25715353", "label": "methods", "text": "Patients in group @ were treated with zinc gluconate for a month and high-dose prednisolone with tapering for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25715353", "label": "methods", "text": "Those in group @ took only zinc gluconate , and those in group @ took only prednisolone .", "sentence_id": 6}
+{"abstract_id": "25715353", "label": "methods", "text": "Patients in group @ did not take any medicine .", "sentence_id": 7}
+{"abstract_id": "25715353", "label": "methods", "text": "All patients were followed up by phenyl ethyl alcohol threshold testing , and magnetic resonance imaging was performed to measure the volume of olfactory bulbs .", "sentence_id": 8}
+{"abstract_id": "25715353", "label": "results", "text": "Thirty-nine patients in group @ , @ in group @ , @ in group @ , and @ in group @ completed the study .", "sentence_id": 9}
+{"abstract_id": "25715353", "label": "results", "text": "The recovery of olfactory function was observed in @ patients ( @ % ) in group @ , in @ ( @ % ) in group @ , in @ ( @ % ) in group @ , and in @ ( @ % ) in group @ .", "sentence_id": 10}
+{"abstract_id": "25715353", "label": "results", "text": "The recovery rates of olfactory function of groups @ and @ were significantly higher than the recovery rate of group @ .", "sentence_id": 11}
+{"abstract_id": "25715353", "label": "results", "text": "The volume of olfactory bulbs was not significantly different between those with and without improved olfactory function .", "sentence_id": 12}
+{"abstract_id": "25715353", "label": "conclusions", "text": "Our results show that zinc gluconate has a promising effect in treating traumatic anosmia .", "sentence_id": 13}
+{"abstract_id": "24359432", "label": "background", "text": "Diabetes mellitus is an increasingly prevalent metabolic disorder that is associated with substantial disease burden .", "sentence_id": 0}
+{"abstract_id": "24359432", "label": "background", "text": "Australia has an opportunity to improve ways of caring for the growing number of people with diabetes , but this may require changes to the way care is funded , organised and delivered .", "sentence_id": 1}
+{"abstract_id": "24359432", "label": "background", "text": "To inform how best to care for people with diabetes , and to identify the extent of change that is required to achieve this , the Diabetes Care Project ( DCP ) will evaluate the impact of two different , evidence-based models of care ( compared to usual care ) on clinical quality , patient and provider experience , and cost .", "sentence_id": 2}
+{"abstract_id": "24359432", "label": "methods", "text": "The DCP uses a pragmatic , cluster randomised controlled trial design .", "sentence_id": 3}
+{"abstract_id": "24359432", "label": "methods", "text": "Accredited general practices that are situated within any of the seven Australian Medicare Locals/Divisions of General Practice that have agreed to take part in the study were invited to participate .", "sentence_id": 4}
+{"abstract_id": "24359432", "label": "methods", "text": "Consenting practices will be randomly assigned to one of three treatment groups for approximately @ to @ months : ( a ) control group ( usual care ) ; ( b ) Intervention @ ( which tests improvements that could be made within the current funding model , facilitated through the use of an online chronic disease management network ) ; or ( c ) Intervention @ ( which includes the same components as Intervention @ , as well as altered funding to support voluntary patient registration with their practice , incentive payments and a care facilitator ) .", "sentence_id": 5}
+{"abstract_id": "24359432", "label": "methods", "text": "Adult patients who attend the enrolled practices and have established ( @ month 's duration ) type @ diabetes mellitus or newly diagnosed or established type @ diabetes mellitus are invited to participate .", "sentence_id": 6}
+{"abstract_id": "24359432", "label": "methods", "text": "Multiple outcomes will be studied , including changes in glycosylated haemoglobin ( primary outcome ) , changes in other biochemical and clinical metrics , incidence of diabetes-related complications , quality of life , clinical depression , success of tailored care , patient and practitioner satisfaction , and budget sustainability .", "sentence_id": 7}
+{"abstract_id": "24359432", "label": "conclusions", "text": "This project responds to a need for robust evidence of the clinical and economic effectiveness of coordinated care for the management of diabetes in the Australian primary care setting .", "sentence_id": 8}
+{"abstract_id": "24359432", "label": "conclusions", "text": "The outcomes of the study will have implications not only for diabetes management , but also for the management of other chronic diseases , both in Australia and overseas .", "sentence_id": 9}
+{"abstract_id": "24297959", "label": "objective", "text": "To investigate and compare the effects of superelastic nickel-titanium and multistranded stainless steel archwires on pain during the initial phase of orthodontic treatment .", "sentence_id": 0}
+{"abstract_id": "24297959", "label": "methods", "text": "A double-blind two-arm parallel design stratified randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "24297959", "label": "methods", "text": "A single centre in India between December @ and June @ .", "sentence_id": 2}
+{"abstract_id": "24297959", "label": "methods", "text": "A total of @ participants ( @ male and @ females ; @ years old ) were randomized ( stratified on age , sex and initial crowding ) to superelastic nickel-titanium or multistranded stainless steel archwire groups using a computer-generated allocation sequence .", "sentence_id": 3}
+{"abstract_id": "24297959", "label": "methods", "text": "We compared @-inch superelastic nickel-titanium and @-inch multistranded stainless steel wires in @-inch slot ( Roth prescription ) preadjusted edgewise appliances .", "sentence_id": 4}
+{"abstract_id": "24297959", "label": "methods", "text": "The follow-up period was @ days .", "sentence_id": 5}
+{"abstract_id": "24297959", "label": "methods", "text": "Outcome was assessed with a visual analogue scale at baseline and @ pre-specified follow-up points .", "sentence_id": 6}
+{"abstract_id": "24297959", "label": "methods", "text": "Data was analyzed using mixed-effects model analysis .", "sentence_id": 7}
+{"abstract_id": "24297959", "label": "results", "text": "One participant was lost to follow up and @ were excluded from the analysis due to bond failure or incomplete questionnaire answers .", "sentence_id": 8}
+{"abstract_id": "24297959", "label": "results", "text": "Ultimately , @ participants ( @ males and @ females ; @ years old ) were analysed for the final results .", "sentence_id": 9}
+{"abstract_id": "24297959", "label": "results", "text": "No statistically significant difference was found for overall pain -LSB- F value = @ , degrees of freedom ( df ) = @ ; P = @ -RSB- .", "sentence_id": 10}
+{"abstract_id": "24297959", "label": "results", "text": "However , compared to multistranded stainless steel wires , pain in subjects with superelastic nickel-titanium archwires was significantly greater at @ h ( t = @ ; P = @ ) , as well as at day @ in the morning ( t = @ , P = @ ) , afternoon ( t = @ , P = @ ) and at bedtime ( t = @ , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24297959", "label": "conclusions", "text": "For overall pain , there was no statistically significant difference between the two wires .", "sentence_id": 12}
+{"abstract_id": "24297959", "label": "conclusions", "text": "However , subjects with superelastic nickel-titanium archwires had a significantly higher pain at peak level .", "sentence_id": 13}
+{"abstract_id": "25457926", "label": "objective", "text": "Neurodevelopmental theories of psychosis highlight the potential benefits of early intervention , prevention , and/or preemption .", "sentence_id": 0}
+{"abstract_id": "25457926", "label": "objective", "text": "How early intervention should take place has not been established , nor whether interventions based on social learning principles can have preemptive effects .", "sentence_id": 1}
+{"abstract_id": "25457926", "label": "objective", "text": "The objective was to test whether a comprehensive psychosocial intervention can significantly alter psychotic symptom trajectories during adolescence-a period of heightened risk for a wide range of psychopathology .", "sentence_id": 2}
+{"abstract_id": "25457926", "label": "methods", "text": "This study was a randomized controlled trial ( RCT ) of Multidimensional Treatment Foster Care ( MTFC ) for delinquent adolescent girls .", "sentence_id": 3}
+{"abstract_id": "25457926", "label": "methods", "text": "Assessment of psychotic symptoms took place at baseline and then @ , @ , @ , and @ months post-baseline using a standardized self-report instrument ( Brief Symptom Inventory ) .", "sentence_id": 4}
+{"abstract_id": "25457926", "label": "methods", "text": "A second source of information about psychotic symptoms was obtained at baseline or @ months , and again at @ months using a structured diagnostic interview ( the Diagnostic Interview Schedule for Children -LSB- DISC -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "25457926", "label": "results", "text": "Significant benefits for MTFC over treatment as usual for psychosis symptoms were observed over a @-month period .", "sentence_id": 6}
+{"abstract_id": "25457926", "label": "results", "text": "Findings were replicated across both measures .", "sentence_id": 7}
+{"abstract_id": "25457926", "label": "results", "text": "Effects were independent of substance use and initial symptom severity and persisted beyond the initial intervention period .", "sentence_id": 8}
+{"abstract_id": "25457926", "label": "conclusions", "text": "Ameliorating nonclinical psychotic symptoms trajectories beginning in mid-adolescence via a multifaceted psychosocial intervention is possible .", "sentence_id": 9}
+{"abstract_id": "25457926", "label": "conclusions", "text": "Developmental research on nonclinical psychotic symptoms and their prognostic value should be complemented by more psychosocial intervention research aimed at modifying these symptom trajectories early in their natural history .", "sentence_id": 10}
+{"abstract_id": "25457926", "label": "conclusions", "text": "Clinical trial registration information-Juvenile Justice Girls Randomized Control Trial : Young Adult Follow-up ; http://clinicaltrials.gov; NCT@ .", "sentence_id": 11}
+{"abstract_id": "24722496", "label": "objective", "text": "INT@ besylate is a potent , nonthiazolidinedione , selective peroxisome proliferator-activated receptor ( PPAR ) modulator ( SPPARM ) designed to improve glucose metabolism while minimizing the side effects of full PPAR agonists .", "sentence_id": 0}
+{"abstract_id": "24722496", "label": "objective", "text": "This placebo-controlled study compared the efficacy and side effects of INT@ besylate versus @ mg pioglitazone HCl in subjects with type @ diabetes ( T@D ) .", "sentence_id": 1}
+{"abstract_id": "24722496", "label": "methods", "text": "This was a @-week randomized , double-blind , placebo - and active-controlled study of @-@ @ mg INT@ versus @ mg pioglitazone or placebo daily in @ subjects with T@D on sulfonylurea or sulfonylurea plus metformin .", "sentence_id": 2}
+{"abstract_id": "24722496", "label": "methods", "text": "The primary efficacy analysis was the comparison of change from baseline to week @ in hemoglobin A@c ( HbA@c ) across treatment groups .", "sentence_id": 3}
+{"abstract_id": "24722496", "label": "methods", "text": "Fluid status was assessed with a prospective scoring system for lower-extremity pitting edema .", "sentence_id": 4}
+{"abstract_id": "24722496", "label": "results", "text": "INT@ had a steep dose response for efficacy as measured by changes in HbA@c .", "sentence_id": 5}
+{"abstract_id": "24722496", "label": "results", "text": "After @ weeks ' treatment , the @-mg dose demonstrated minimal efficacy ( HbA@c -@ @ % ) and the @-mg dose demonstrated near-maximal efficacy ( HbA@c -@ @ % ) , which was not statistically different from the efficacy of @ mg pioglitazone ( HbA@c -@ @ % ; P < @ for noninferiority ) .", "sentence_id": 6}
+{"abstract_id": "24722496", "label": "results", "text": "With the @-mg dose , INT@ provided significant improvements in glycemic control ( HbA@c @ @ ; P < @ vs. placebo ) but with less edema , weight gain , and hemodilution than observed with @ mg pioglitazone .", "sentence_id": 7}
+{"abstract_id": "24722496", "label": "conclusions", "text": "INT@ demonstrated dose-dependent reductions in HbA@c , equivalent to @ mg pioglitazone , but with less fluid accumulation and weight gain , consistent with its SPPARM design .", "sentence_id": 8}
+{"abstract_id": "25007091", "label": "methods", "text": "HIV-@ vaccine development has advanced slowly due to viral antigenic diversity , poor immunogenicity and recently , safety concerns associated with human adenovirus serotype-@ vectors .", "sentence_id": 0}
+{"abstract_id": "25007091", "label": "methods", "text": "To tackle HIV-@ variation , we designed a unique T-cell immunogen HIVconsv from functionally conserved regions of the HIV-@ proteome , which were presented to the immune system using a heterologous prime-boost combination of plasmid DNA , a non-replicating simian ( chimpanzee ) adenovirus ChAdV-@ and a non-replicating poxvirus , modified vaccinia virus Ankara .", "sentence_id": 1}
+{"abstract_id": "25007091", "label": "methods", "text": "A block-randomized , single-blind , placebo-controlled phase I trial HIV-CORE @ administered for the first time candidate HIV-@ - vaccines or placebo to @ healthy HIV-@ / @-uninfected adults in Oxford , UK and elicited high frequencies of HIV-@-specific T cells capable of inhibiting HIV-@ replication in vitro .", "sentence_id": 2}
+{"abstract_id": "25007091", "label": "methods", "text": "Here , detail safety and tolerability of these vaccines are reported .", "sentence_id": 3}
+{"abstract_id": "25007091", "label": "methods", "text": "Local and systemic reactogenicity data were collected using structured interviews and study-specific diary cards .", "sentence_id": 4}
+{"abstract_id": "25007091", "label": "methods", "text": "Data on all other adverse events were collected using open questions .", "sentence_id": 5}
+{"abstract_id": "25007091", "label": "methods", "text": "Serum neutralizing antibody titres to ChAdV-@ were determined before and after vaccination .", "sentence_id": 6}
+{"abstract_id": "25007091", "label": "results", "text": "Two volunteers withdrew for vaccine-unrelated reasons .", "sentence_id": 7}
+{"abstract_id": "25007091", "label": "results", "text": "No vaccine-related serious adverse events or reactions occurred during @ person-months of follow-up .", "sentence_id": 8}
+{"abstract_id": "25007091", "label": "results", "text": "Local and systemic events after vaccination occurred in @/@ individuals and most were mild ( severity grade @ ) and predominantly transient ( < @ hours ) .", "sentence_id": 9}
+{"abstract_id": "25007091", "label": "results", "text": "Myalgia and flu-like symptoms were more strongly associated with MVA than ChAdV@ or DNA vectors and more common in vaccine recipients than in placebo .", "sentence_id": 10}
+{"abstract_id": "25007091", "label": "results", "text": "There were no intercurrent HIV-@ infections during follow-up .", "sentence_id": 11}
+{"abstract_id": "25007091", "label": "results", "text": "@/@ volunteers had low ChAdV-@-neutralizing titres at baseline and @ increased their titres to over @ with a median ( range ) of @ ( @-@ ) post-vaccination , which is of no safety concern .", "sentence_id": 12}
+{"abstract_id": "25007091", "label": "conclusions", "text": "These data demonstrate safety and good tolerability of the pSG@.HIVconsv DNA , ChAdV@.HIVconsv and MVA.HIVconsv vaccines and together with their high immunogenicity support their further development towards efficacy studies .", "sentence_id": 13}
+{"abstract_id": "25304191", "label": "background", "text": "Low levels of health-enhancing physical activity require novel approaches that have the potential to reach broad populations .", "sentence_id": 0}
+{"abstract_id": "25304191", "label": "background", "text": "Web-based interventions are a popular approach for behaviour change given their wide reach and accessibility .", "sentence_id": 1}
+{"abstract_id": "25304191", "label": "background", "text": "However , challenges with participant engagement and retention reduce the long-term maintenance of behaviour change .", "sentence_id": 2}
+{"abstract_id": "25304191", "label": "background", "text": "Web @ features present a new and innovative online environment supporting greater interactivity , with the potential to increase engagement and retention .", "sentence_id": 3}
+{"abstract_id": "25304191", "label": "background", "text": "In order to understand the applicability of these innovative interventions for the broader population , ` real-world ' interventions implemented under ` everyday conditions ' are required .", "sentence_id": 4}
+{"abstract_id": "25304191", "label": "background", "text": "The aim of this study is to investigate the difference in physical activity behaviour between individuals using a traditional Web @ website with those using a novel Web @ website .", "sentence_id": 5}
+{"abstract_id": "25304191", "label": "methods", "text": "In this study we will aim to recruit @ participants .", "sentence_id": 6}
+{"abstract_id": "25304191", "label": "methods", "text": "Participants will be recruited from individuals who register with a pre-existing health promotion website that currently provides Web @ features ( http://www@steps.org.au ) .", "sentence_id": 7}
+{"abstract_id": "25304191", "label": "methods", "text": "Eligible participants who provide informed consent will be randomly assigned to one of the two trial conditions : the pre-existing @ Steps website ( with Web @ features ) or the newly developed WALK @ website ( with Web @ features ) .", "sentence_id": 8}
+{"abstract_id": "25304191", "label": "methods", "text": "Primary and secondary outcome measures will be assessed by self-report at baseline , @months and @months , and include : physical activity behaviour , height and weight , Internet self-efficacy , website usability , website usage and quality of life .", "sentence_id": 9}
+{"abstract_id": "24679401", "label": "background", "text": "Research suggests that people with bipolar disorder may be highly motivated to attain dominance and may over-estimate their social power ( Johnson and Carver , @ ) .", "sentence_id": 0}
+{"abstract_id": "24679401", "label": "background", "text": "This manic temperament may provide an adaptive advantage in the pursuit of dominance and leadership ( Akiskal and Akiskal , @ ) .", "sentence_id": 1}
+{"abstract_id": "24679401", "label": "background", "text": "It was hypothesized that people at high risk for bipolar disorder , as defined by the Hypomanic Personality Scale ( HPS ) , would fail to assume a submissive role when it was appropriate to do so .", "sentence_id": 2}
+{"abstract_id": "24679401", "label": "methods", "text": "Participants ( @ undergraduates ) completed an image description task with a confederate .", "sentence_id": 3}
+{"abstract_id": "24679401", "label": "methods", "text": "Participants were randomly assigned to interact with a confederate who assumed one of three nonverbal postures : dominant ( expanded ) , neutral , or submissive ( constricted ) .", "sentence_id": 4}
+{"abstract_id": "24679401", "label": "methods", "text": "Nonverbal dominance behavior was defined as the rate at which participants expanded their body span during the task .", "sentence_id": 5}
+{"abstract_id": "24679401", "label": "results", "text": "Consistent with hypotheses , an ANOVA indicated an interaction of Mania risk x Dominance condition on body expansion .", "sentence_id": 6}
+{"abstract_id": "24679401", "label": "results", "text": "Whereas participants with low mania risk ( HPS scores ) adapted complementary behavior in response to the confederate , participants with high mania risk demonstrated a consistently dominant ( expanded ) nonverbal posture .", "sentence_id": 7}
+{"abstract_id": "24679401", "label": "conclusions", "text": "A major limitation of this study is the use of an analog measure of mania risk in place of clinical diagnoses .", "sentence_id": 8}
+{"abstract_id": "24679401", "label": "conclusions", "text": "In this experiment , participants at high risk for mania maintained a dominant posture even when submissiveness would have been more appropriate .", "sentence_id": 9}
+{"abstract_id": "24679401", "label": "conclusions", "text": "It is argued that persistent dominance behavior may play an important role in the interpersonal interactions of individuals at risk for bipolar disorder .", "sentence_id": 10}
+{"abstract_id": "25624374", "label": "background", "text": "Inadequate designs and conflicting results from previous studies prompted the US Food and Drug Administration to publish guidelines for the design of clinical trials evaluating the effects of orally inhaled and intranasal corticosteroids on the growth of children .", "sentence_id": 0}
+{"abstract_id": "25624374", "label": "background", "text": "This study conformed to these guidelines to evaluate the effect of triamcinolone acetonide aqueous nasal spray ( TAA-AQ ) on the growth of children with perennial allergic rhinitis ( PAR ) .", "sentence_id": 1}
+{"abstract_id": "25624374", "label": "methods", "text": "This randomized , double-blind , placebo-controlled , parallel-group , multicenter study evaluated the effect of once-daily TAA-AQ ( @ g ) on the growth velocity ( GV ) of children aged @-@ years with PAR by using stadiometry at baseline ( @-@ months ) , during treatment ( @ months ) , and at follow-up ( @ months ) .", "sentence_id": 2}
+{"abstract_id": "25624374", "label": "methods", "text": "Hypothalamus-pituitary-adrenal ( HPA ) axis function was assessed by measuring urinary cortisol levels .", "sentence_id": 3}
+{"abstract_id": "25624374", "label": "methods", "text": "Details of adverse events were recorded .", "sentence_id": 4}
+{"abstract_id": "25624374", "label": "results", "text": "Of @ subjects screened , @ were randomized , and @ completed the study ( placebo , @ ; TAA-AQ , @ ) .", "sentence_id": 5}
+{"abstract_id": "25624374", "label": "results", "text": "In the primary analysis ( modified intent-to-treat : placebo , @ ; TAA-AQ , @ ) , least-squares mean GV during treatment was lower in the TAA-AQ group ( @ cm/year ) versus placebo ( @ cm/year ) .", "sentence_id": 6}
+{"abstract_id": "25624374", "label": "results", "text": "The difference ( -@ cm/year ; @ % confidence interval : -@ to -@ ; P = @ ) , although clinically nonsignificant , was evident within @ months of treatment and stabilized thereafter .", "sentence_id": 7}
+{"abstract_id": "25624374", "label": "results", "text": "At follow-up , the GV approached baseline ( @ cm/year ) in the TAA-AQ group ( @ cm/year ) and decreased slightly in the placebo group ( @ cm/year vs @ cm/year at baseline ) .", "sentence_id": 8}
+{"abstract_id": "25624374", "label": "results", "text": "No HPA axis suppression was observed .", "sentence_id": 9}
+{"abstract_id": "25624374", "label": "conclusions", "text": "By using rigorous Food and Drug Administration-recommended design elements , this study detected a small , statistically significant effect of TAA-AQ on the GV of children with PAR .", "sentence_id": 10}
+{"abstract_id": "25020061", "label": "objective", "text": "Fasting is characterised by profound changes in energy metabolism including progressive loss of body proteins .", "sentence_id": 0}
+{"abstract_id": "25020061", "label": "objective", "text": "The underlying mechanisms are however unknown and we therefore determined the effects of a @-hour-fast on human skeletal muscle protein metabolism and activation of mammalian target of rapamycin ( mTOR ) , a key regulator of cell growth .", "sentence_id": 1}
+{"abstract_id": "25020061", "label": "methods", "text": "Eight healthy male volunteers were studied twice : in the postabsorptive state and following @ hours of fasting .", "sentence_id": 2}
+{"abstract_id": "25020061", "label": "methods", "text": "Regional muscle amino acid kinetics was measured in the forearm using amino acid tracers .", "sentence_id": 3}
+{"abstract_id": "25020061", "label": "methods", "text": "Signaling to protein synthesis and breakdown were assessed in skeletal muscle biopsies obtained during non-insulin and insulin stimulated conditions on both examination days .", "sentence_id": 4}
+{"abstract_id": "25020061", "label": "results", "text": "Fasting significantly increased forearm net phenylalanine release and tended to decrease phenylalanine rate of disappearance .", "sentence_id": 5}
+{"abstract_id": "25020061", "label": "results", "text": "mTOR phosphorylation was decreased by @ % following fasting , together with reduced downstream phosphorylation of @EBP@ , ULK@ and rpS@ .", "sentence_id": 6}
+{"abstract_id": "25020061", "label": "results", "text": "In addition , the insulin stimulated increase in mTOR and rpS@ phosphorylation was significantly reduced after fasting indicating insulin resistance in this part of the signaling pathway .", "sentence_id": 7}
+{"abstract_id": "25020061", "label": "results", "text": "Autophagy initiation is in part regulated by mTOR through ULK@ and fasting increased expression of the autophagic marker LC@B-II by @ % .", "sentence_id": 8}
+{"abstract_id": "25020061", "label": "results", "text": "p@ is degraded during autophagy but was increased by @ % during fasting making interpretation of autophagic flux problematic .", "sentence_id": 9}
+{"abstract_id": "25020061", "label": "results", "text": "MAFbx and MURF@ ubiquitin ligases remained unaltered after fasting indicating no change in protesomal protein degradation .", "sentence_id": 10}
+{"abstract_id": "25020061", "label": "conclusions", "text": "Our results show that during fasting increased net phenylalanine release in skeletal muscle is associated to reduced mTOR activation and concomitant decreased downstream signaling to cell growth .", "sentence_id": 11}
+{"abstract_id": "24797376", "label": "objective", "text": "To evaluate the efficacy of IV iron supplementation of anemic , critically ill trauma patients .", "sentence_id": 0}
+{"abstract_id": "24797376", "label": "methods", "text": "Multicenter , randomized , single-blind , placebo-controlled trial .", "sentence_id": 1}
+{"abstract_id": "24797376", "label": "methods", "text": "Four trauma ICUs .", "sentence_id": 2}
+{"abstract_id": "24797376", "label": "methods", "text": "Anemic ( hemoglobin < @g/dL ) trauma patients enrolled within @ hours of ICU admission and with an expected ICU length of stay of more than or equal to @ days .", "sentence_id": 3}
+{"abstract_id": "24797376", "label": "methods", "text": "Randomization to iron sucrose @mg IV or placebo thrice weekly for up to @ weeks .", "sentence_id": 4}
+{"abstract_id": "24797376", "label": "results", "text": "A total of @ patients were enrolled .", "sentence_id": 5}
+{"abstract_id": "24797376", "label": "results", "text": "Baseline iron markers were consistent with functional iron deficiency : @ patients ( @ % ) were hypoferremic , @ ( @ % ) were hyperferritinemic , and @ ( @ % ) demonstrated iron-deficient erythropoiesis as evidenced by an elevated erythrocyte zinc protoporphyrin concentration .", "sentence_id": 6}
+{"abstract_id": "24797376", "label": "results", "text": "The median baseline transferrin saturation was @ % ( range , @-@ % ) .", "sentence_id": 7}
+{"abstract_id": "24797376", "label": "results", "text": "In the subgroup of patients who received all six doses of study drug ( n = @ ) , the serum ferritin concentration increased significantly for the iron as compared with placebo group on both day @ ( @ ng/mL vs @ ng/mL , respectively , p < @ ) and day @ ( @,@ ng/mL vs @ ng/mL , respectively , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24797376", "label": "results", "text": "There was no significant difference between groups in transferrin saturation , erythrocyte zinc protoporphyrin concentration , hemoglobin concentration , or packed RBC transfusion requirement .", "sentence_id": 9}
+{"abstract_id": "24797376", "label": "results", "text": "There was no significant difference between groups in the risk of infection , length of stay , or mortality .", "sentence_id": 10}
+{"abstract_id": "24797376", "label": "conclusions", "text": "Iron supplementation increased the serum ferritin concentration significantly , but it had no discernible effect on transferrin saturation , iron-deficient erythropoiesis , hemoglobin concentration , or packed RBC transfusion requirement .", "sentence_id": 11}
+{"abstract_id": "24797376", "label": "conclusions", "text": "Based on these data , routine IV iron supplementation of anemic , critically ill trauma patients can not be recommended ( NCT @ ) .", "sentence_id": 12}
+{"abstract_id": "24682346", "label": "background", "text": "Allogeneic mesenchymal precursor cells ( MPCs ) injected during left ventricular assist device ( LVAD ) implantation may contribute to myocardial recovery .", "sentence_id": 0}
+{"abstract_id": "24682346", "label": "background", "text": "This trial explores the safety and efficacy of this strategy .", "sentence_id": 1}
+{"abstract_id": "24682346", "label": "results", "text": "In this multicenter , double-blind , sham-procedure controlled trial , @ patients were randomized ( @:@ ) to intramyocardial injection of @ million MPCs or medium during LVAD implantation .", "sentence_id": 2}
+{"abstract_id": "24682346", "label": "results", "text": "The primary safety end point was incidence of infectious myocarditis , myocardial rupture , neoplasm , hypersensitivity reaction , and immune sensitization ( @ days after randomization ) .", "sentence_id": 3}
+{"abstract_id": "24682346", "label": "results", "text": "Key efficacy end points were functional status and ventricular function while temporarily weaned from LVAD support ( @ days after randomization ) .", "sentence_id": 4}
+{"abstract_id": "24682346", "label": "results", "text": "Patients were followed up until transplant or @ months after randomization , whichever came first .", "sentence_id": 5}
+{"abstract_id": "24682346", "label": "results", "text": "Mean age was @ ( @ ) years , mean left ventricular ejection fraction was @ % , and @ % were destination therapy LVADs .", "sentence_id": 6}
+{"abstract_id": "24682346", "label": "results", "text": "No safety events were observed .", "sentence_id": 7}
+{"abstract_id": "24682346", "label": "results", "text": "Successful temporary LVAD weaning was achieved in @ % of MPC and @ % of control patients at @ days ( P = @ ) ; the posterior probability that MPCs increased the likelihood of successful weaning was @ % .", "sentence_id": 8}
+{"abstract_id": "24682346", "label": "results", "text": "At @ days , @ deaths ( @ % ) occurred in control patients , and none occurred in MPC patients .", "sentence_id": 9}
+{"abstract_id": "24682346", "label": "results", "text": "Mean left ventricular ejection fraction after successful wean was @ % ( MPC = @ ) and @ % ( control = @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24682346", "label": "results", "text": "At @ months , @ % of MPC patients and @ % of control patients were successfully temporarily weaned from LVAD support ( P = @ ) , and @ deaths ( @ % ) occurred in MPC patients .", "sentence_id": 11}
+{"abstract_id": "24682346", "label": "results", "text": "Donor-specific HLA sensitization developed in @ MPC and @ control patients and resolved by @ months .", "sentence_id": 12}
+{"abstract_id": "24682346", "label": "conclusions", "text": "In this preliminary trial , administration of MPCs appeared to be safe , and there was a potential signal of efficacy .", "sentence_id": 13}
+{"abstract_id": "24682346", "label": "conclusions", "text": "Future studies will evaluate the potential for higher or additional doses to enhance the ability to wean LVAD recipients off support .", "sentence_id": 14}
+{"abstract_id": "25248910", "label": "objective", "text": "Efforts to reduce disparities in recurrent stroke among Black and Latino stroke survivors have met with limited success .", "sentence_id": 0}
+{"abstract_id": "25248910", "label": "objective", "text": "We aimed to determine the effect of peer education on secondary stroke prevention among predominantly minority stroke survivors .", "sentence_id": 1}
+{"abstract_id": "25248910", "label": "methods", "text": "Between @ and @ , we enrolled @ stroke or transient ischemic attack survivors from diverse , low-income communities in New York City into a @-arm randomized clinical trial that compared a @ week ( @ session/week ) , peer-led , community-based , stroke prevention self-management group workshop ( N = @ ) to a wait-list control group ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "25248910", "label": "methods", "text": "The primary outcome was the proportion with a composite of controlled blood pressure ( < @/@ mm Hg ) , low-density lipoprotein cholesterol < @ mg/dL , and use of antithrombotic medications at @ months .", "sentence_id": 3}
+{"abstract_id": "25248910", "label": "methods", "text": "Secondary outcomes included control of the individual stroke risk factors .", "sentence_id": 4}
+{"abstract_id": "25248910", "label": "methods", "text": "All analyses were by intent-to-treat .", "sentence_id": 5}
+{"abstract_id": "25248910", "label": "results", "text": "There was no difference in the proportion of intervention and control group participants achieving the composite outcome ( @ % versus @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25248910", "label": "results", "text": "The proportion with controlled blood pressure at @ months was greater in the intervention group than in the control group ( @ % versus @ % ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25248910", "label": "results", "text": "This corresponded to a greater change in systolic blood pressure in the intervention versus control group ( -@ SD , @ mm Hg versus +@ SD , @ mm Hg ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25248910", "label": "results", "text": "There were no group differences in the control of cholesterol or use of antithrombotics .", "sentence_id": 9}
+{"abstract_id": "25248910", "label": "conclusions", "text": "A low-cost peer education self-management workshop modestly improved blood pressure , but not low-density lipoprotein cholesterol or antithrombotic use , among stroke and transient ischemic attack survivors from vulnerable , predominantly minority urban communities .", "sentence_id": 10}
+{"abstract_id": "24850107", "label": "background", "text": "Despite @ years of clinical research , we still do not know the optimal dose of intrathecal morphine ( ITM ) when used alone .", "sentence_id": 0}
+{"abstract_id": "24850107", "label": "objective", "text": "A safety investigation and comparison of the analgesic efficacy of ITM @ mg , @ mg , and @ mg in patients undergoing major abdominal cancer surgery .", "sentence_id": 1}
+{"abstract_id": "24850107", "label": "methods", "text": "A randomized , double-blind trial .", "sentence_id": 2}
+{"abstract_id": "24850107", "label": "methods", "text": "Academic medical center .", "sentence_id": 3}
+{"abstract_id": "24850107", "label": "methods", "text": "Ninety patients were randomly assigned to receive morphine intrathecally either @ mg ( Group I , ITM @ mg , n = @ ) , @ mg ( Group II , ITM @ mg , n = @ ) , or @ mg ( Group III , ITM @ mg , n = @ ) dissolved in @ mL physiological saline before general anesthesia .", "sentence_id": 4}
+{"abstract_id": "24850107", "label": "methods", "text": "Assessment parameters included hemodynamics , respiratory rate , peripheral arterial oxygenation , sedation score , pain severity , time of first analgesic request , total analgesic consumption , and side effects in the first @ hours .", "sentence_id": 5}
+{"abstract_id": "24850107", "label": "results", "text": "The mean time to first request for rescue analgesia was significantly prolonged in Group II ( @ @ hours , P < @ ) and Group III ( @ @ h , P < @ ) , compared with Group I ( @ @ hours ) .", "sentence_id": 6}
+{"abstract_id": "24850107", "label": "results", "text": "The mean tramadol consumption dose was significantly reduced in Group II ( @ @ mg , P < @ ) and Group III ( @ @ mg , P < @ ) compared with Group I ( @ @ mg ) .", "sentence_id": 7}
+{"abstract_id": "24850107", "label": "results", "text": "Patients received @ mg ITM showed lower VAS scores in the first @ h postoperative ( P < @ ) compared with Group I and Group II .", "sentence_id": 8}
+{"abstract_id": "24850107", "label": "results", "text": "No significant differences were observed in the mean systolic and diastolic blood pressure values , respiratory rate , and peripheral arterial oxygen saturation between groups .", "sentence_id": 9}
+{"abstract_id": "24850107", "label": "results", "text": "Lower mean heart rate values were observed in Group III patients at @ hours ( P < @ ) and @ hours ( P < @ ) postoperative compared with Group I and Group II patients .", "sentence_id": 10}
+{"abstract_id": "24850107", "label": "results", "text": "Six patients ( @ % ) in Group II and @ ( @ % ) in Group III exhibited pruritus compared with @ patients ( @ % ) in Group I ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24850107", "label": "results", "text": "No intergroup statistical differences were observed for other studied side effects .", "sentence_id": 12}
+{"abstract_id": "24850107", "label": "conclusions", "text": "This study is limited by its small sample size .", "sentence_id": 13}
+{"abstract_id": "24850107", "label": "conclusions", "text": "One mg ITM provided superior analgesia for @ hours postoperative compared with @ mg and @ mg ITM with a nonsignificant difference in the incidence of side effects .", "sentence_id": 14}
+{"abstract_id": "24850107", "label": "conclusions", "text": "Further studies of larger sample size are recommended to confirm these findings .", "sentence_id": 15}
+{"abstract_id": "25616289", "label": "objective", "text": "To study the efficacy of Huai Qi Huang granules in the treatment of childhood primary nephrotic syndrome .", "sentence_id": 0}
+{"abstract_id": "25616289", "label": "methods", "text": "Between July @ and December @ , patients who were admitted and diagnosed for the first time as childhood primary nephrotic syndrome were randomized into a treatment group ( Huai Qi Huang granules plus glucocorticoid ; n = @ ) and a control group ( glucocorticoid alone ; n = @ ) for a prospective study .", "sentence_id": 1}
+{"abstract_id": "25616289", "label": "methods", "text": "The two groups were compared for regression time of edema , time to urinary protein clearance , relapse rate , incidence of infection , dosage of glucocorticoid , and humoral and cellular immunological indicators .", "sentence_id": 2}
+{"abstract_id": "25616289", "label": "results", "text": "There were no significant differences in regression time of edema , time to urinary protein clearance , and relapse rate between the treatment and control groups ( P > @ ) .", "sentence_id": 3}
+{"abstract_id": "25616289", "label": "results", "text": "The treatment group had significantly lower incidence of infection and daily dose of glucocorticoid ( at month @ ) than the control group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25616289", "label": "results", "text": "Humoral and cellular immunological indicators showed no significant differences between the two groups ( P > @ ) .", "sentence_id": 5}
+{"abstract_id": "25616289", "label": "results", "text": "No Huai Qi Huang-related adverse events were observed in this study .", "sentence_id": 6}
+{"abstract_id": "25616289", "label": "conclusions", "text": "Huai Qi Huang granules treatment can reduce the dose of glucocorticoid and the incidence of infection in children with primary nephrotic syndrome and has a favourable safety .", "sentence_id": 7}
+{"abstract_id": "25323890", "label": "objective", "text": "Bowel cleansing is generally regarded as time-consuming and unpleasant among patients .", "sentence_id": 0}
+{"abstract_id": "25323890", "label": "objective", "text": "Patients commonly state that bowel preparation provokes more discomfort than the actual colonoscopic examination .", "sentence_id": 1}
+{"abstract_id": "25323890", "label": "objective", "text": "The purpose of this study was to compare two regimens of sodium phosphate ( NaP ) tablets versus polyethylene glycol ( PEG ) solution for bowel preparation in healthy Korean adults .", "sentence_id": 2}
+{"abstract_id": "25323890", "label": "methods", "text": "This was a single center , prospective , open-label , investigator-blinded , randomized , controlled-pilot study .", "sentence_id": 3}
+{"abstract_id": "25323890", "label": "methods", "text": "A total of @ healthy Korean subjects were randomly assigned to two groups ( NaP vs. PEG ) .", "sentence_id": 4}
+{"abstract_id": "25323890", "label": "methods", "text": "Efficacy , safety , and patient-related outcomes , as well as procedural parameters , were evaluated .", "sentence_id": 5}
+{"abstract_id": "25323890", "label": "results", "text": "Although there were no significant differences in total Ottawa bowel quality score , fluid scores and the rate of adequate bowel preparation were significantly better in the NaP group than the PEG group .", "sentence_id": 6}
+{"abstract_id": "25323890", "label": "results", "text": "Additionally , the NaP group showed better results regarding patient tolerance , satisfaction , preference , and rate of adverse events than the PEG group .", "sentence_id": 7}
+{"abstract_id": "25323890", "label": "results", "text": "Significant fluctuations in specific serum electrolytes were common and of a greater magnitude in the NaP group than the PEG group .", "sentence_id": 8}
+{"abstract_id": "25323890", "label": "results", "text": "However , these abnormalities were transient and did not result in serious complications and side effects .", "sentence_id": 9}
+{"abstract_id": "25323890", "label": "conclusions", "text": "In this study , NaP tablets were shown to be an effective , well-tolerated , and acceptable regimen for bowel preparation .", "sentence_id": 10}
+{"abstract_id": "25323890", "label": "conclusions", "text": "Also , our study suggests that NaP tablets may be safe and can be used as a bowel cleansing agent in healthy adults undergoing elective colonoscopy .", "sentence_id": 11}
+{"abstract_id": "25323890", "label": "conclusions", "text": "Further multicenter , large scale studies are needed to confirm these findings .", "sentence_id": 12}
+{"abstract_id": "24646123", "label": "background", "text": "Nepal is on track to achieve MDG @ but there is a huge sub-national disparity with existing high maternal mortality in western and hilly regions .", "sentence_id": 0}
+{"abstract_id": "24646123", "label": "background", "text": "The national priority is to reduce this disparity to achieve the goal at sub-national level .", "sentence_id": 1}
+{"abstract_id": "24646123", "label": "background", "text": "Evidences from developing countries show that increasing utilization of skilled attendant at birth is an important indicator for reducing maternal death .", "sentence_id": 2}
+{"abstract_id": "24646123", "label": "background", "text": "Further , there is a very low utilization during childbirth in western and hilly regions of Nepal which clearly depicts the barriers in utilization of skilled birth attendants .", "sentence_id": 3}
+{"abstract_id": "24646123", "label": "background", "text": "So , there is a need to overcome the identified barriers to increase the utilization thereby decreasing the maternal mortality .", "sentence_id": 4}
+{"abstract_id": "24646123", "label": "background", "text": "The hypothesis of this study is that through a package of interventions the utilization of skilled birth attendants will be increased and hence improve maternal health in Nepal .", "sentence_id": 5}
+{"abstract_id": "24646123", "label": "methods", "text": "This study involves a cluster randomized controlled trial involving approximately @ pregnant women in @ clusters .", "sentence_id": 6}
+{"abstract_id": "24646123", "label": "methods", "text": "The @ intervention clusters will receive the following interventions : i ) mobilization of family support for pregnant women to reach the health facility , ii ) availability of emergency funds for institutional childbirth , iii ) availability of transport options to reach a health facility for childbirth , iv ) training to health workers on communication skills , v ) security provisions for SBAs to reach services @/@ through community mobilization ; @ control clusters will not receive the intervention package .", "sentence_id": 7}
+{"abstract_id": "24646123", "label": "methods", "text": "The final evaluation of the intervention is planned to be completed by October @ .", "sentence_id": 8}
+{"abstract_id": "24646123", "label": "methods", "text": "Primary study output of this study is utilization of SBA services .", "sentence_id": 9}
+{"abstract_id": "24646123", "label": "methods", "text": "Secondary study outputs measure the uptake of antenatal care , post natal checkup for mother and baby , availability of transportation for childbirth , operation of emergency fund , improved reception of women at health services , and improved physical security of SBAs .", "sentence_id": 10}
+{"abstract_id": "24646123", "label": "conclusions", "text": "The intervention package is designed to increase the utilization of skilled birth attendants by overcoming the barriers related to awareness , finance , transport , security etc. .", "sentence_id": 11}
+{"abstract_id": "24646123", "label": "conclusions", "text": "If proven effective , the Ministry of Health has committed to scale up the intervention package throughout the country .", "sentence_id": 12}
+{"abstract_id": "25259787", "label": "background", "text": "Progressive midlife weight gain is associated with multiple adverse health outcomes and may represent an early manifestation of insulin resistance in a distinct subset of women .", "sentence_id": 0}
+{"abstract_id": "25259787", "label": "background", "text": "Emerging data implicate hyperinsulinema as a proximate cause of weight gain and support strategies that attenuate insulin secretion .", "sentence_id": 1}
+{"abstract_id": "25259787", "label": "objective", "text": "To assess a previously reported novel hypocaloric carbohydrate modified diet alone ( D ) , and in combination with metformin ( M ) and metformin plus low-dose rosiglitazone ( MR ) , in diverse women with midlife weight gain ( defined as > @lbs since the twenties ) , normal glucose tolerance , and hyperinsulinemia .", "sentence_id": 2}
+{"abstract_id": "25259787", "label": "methods", "text": "@ women , mean age @ , BMI @ kg/m@ , @ % white , @ % black , @ % Hispanic , at @ university medical centers .", "sentence_id": 3}
+{"abstract_id": "25259787", "label": "methods", "text": "A dietary intervention designed to reduce insulin excursions was implemented in @ weekly nutritional group workshops prior to randomization .", "sentence_id": 4}
+{"abstract_id": "25259787", "label": "methods", "text": "Change in @-month fasting insulin .", "sentence_id": 5}
+{"abstract_id": "25259787", "label": "methods", "text": "Pre-specified secondary outcomes were changes in body weight , HOMA-IR , metabolic syndrome ( MS ) measures , leptin , and adiponectin .", "sentence_id": 6}
+{"abstract_id": "25259787", "label": "results", "text": "Six-month fasting insulin declined significantly in the M group : @ to @ U/ml , p = @ .", "sentence_id": 7}
+{"abstract_id": "25259787", "label": "results", "text": "Mean @-month weight decreased significantly and comparably in D , M , and MR groups : @ , @ , and @ % ( p 's @ , @ , and @ ) .", "sentence_id": 8}
+{"abstract_id": "25259787", "label": "results", "text": "HOMA-IR decreased in M and MR groups ( @ to @ and @ to @ , p 's = @ , @ ) .", "sentence_id": 9}
+{"abstract_id": "25259787", "label": "results", "text": "Additional improvement in MS measures included reduced waist circumference in D and MR groups and increased HDL in the D and M groups .", "sentence_id": 10}
+{"abstract_id": "25259787", "label": "results", "text": "Notably , mean fasting leptin did not decline in a subset of subjects with weight loss ( @ ng/ml to @ ng/ml , p = @ .", "sentence_id": 11}
+{"abstract_id": "25259787", "label": "results", "text": "Adiponectin increased significantly in the MR group ( @ to @ , p < @ ) Study medications were well tolerated .", "sentence_id": 12}
+{"abstract_id": "25259787", "label": "conclusions", "text": "These findings suggest that EMPOWIR 's easily implemented dietary interventions , alone and in combination with pharmacotherapies that target hyperinsulinemia , merit additional investigation in larger , long-term studies .", "sentence_id": 13}
+{"abstract_id": "24597650", "label": "background", "text": "Virtual reality ( VR ) is not commonly used in clinical rehabilitation , and commercial VR gaming systems may have mixed effects in patients with stroke .", "sentence_id": 0}
+{"abstract_id": "24597650", "label": "background", "text": "Therefore , we developed RehabMaster , a task-specific interactive game-based VR system for post-stroke rehabilitation of the upper extremities , and assessed its usability and clinical efficacy .", "sentence_id": 1}
+{"abstract_id": "24597650", "label": "methods", "text": "A participatory design and usability tests were carried out for development of RehabMaster with representative user groups .", "sentence_id": 2}
+{"abstract_id": "24597650", "label": "methods", "text": "Two clinical trials were then performed .", "sentence_id": 3}
+{"abstract_id": "24597650", "label": "methods", "text": "The first was an observational study in which seven patients with chronic stroke received @ minutes of RehabMaster intervention per day for two weeks .", "sentence_id": 4}
+{"abstract_id": "24597650", "label": "methods", "text": "The second was a randomised controlled trial of @ patients with acute or subacute stroke who received @ sessions of conventional occupational therapy only ( OT-only group ) or conventional occupational therapy plus @ minutes of RehabMaster intervention ( RehabMaster + OT group ) .", "sentence_id": 5}
+{"abstract_id": "24597650", "label": "methods", "text": "The Fugl-Meyer Assessment score ( FMA ) , modified Barthel Index ( MBI ) , adverse effects , and drop-out rate were recorded .", "sentence_id": 6}
+{"abstract_id": "24597650", "label": "results", "text": "The requirements of a VR system for stroke rehabilitation were established and incorporated into RehabMaster .", "sentence_id": 7}
+{"abstract_id": "24597650", "label": "results", "text": "The reported advantages from the usability tests were improved attention , the immersive flow experience , and individualised intervention .", "sentence_id": 8}
+{"abstract_id": "24597650", "label": "results", "text": "The first clinical trial showed that the RehabMaster intervention improved the FMA ( P = @ ) and MBI ( P = @ ) across evaluation times .", "sentence_id": 9}
+{"abstract_id": "24597650", "label": "results", "text": "The second trial revealed that the addition of RehabMaster intervention tended to enhance the improvement in the FMA ( P = @ ) but did not affect the improvement in the MBI .", "sentence_id": 10}
+{"abstract_id": "24597650", "label": "results", "text": "One patient with chronic stroke left the trial , and no adverse effects were reported .", "sentence_id": 11}
+{"abstract_id": "24597650", "label": "conclusions", "text": "The RehabMaster is a feasible and safe VR system for enhancing upper extremity function in patients with stroke .", "sentence_id": 12}
+{"abstract_id": "25481364", "label": "objective", "text": "The volume of a fibroid uterus before performing hysterectomy is typically estimated through bimanual examination and confirmed by ultrasonography .", "sentence_id": 0}
+{"abstract_id": "25481364", "label": "objective", "text": "This study compares estimated volumes by bimanual examination and ultrasound examination with MRI and actual volumes obtained from histopathology , as gold standards .", "sentence_id": 1}
+{"abstract_id": "25481364", "label": "methods", "text": "We used data from a previous prospective randomized multi-center trial that compared hysterectomy and uterine artery embolization ( UAE ) for the treatment of symptomatic fibroids .", "sentence_id": 2}
+{"abstract_id": "25481364", "label": "methods", "text": "All patients underwent bimanual vaginal examination and pelvic ultrasonography .", "sentence_id": 3}
+{"abstract_id": "25481364", "label": "methods", "text": "Those women randomized to UAE received a pelvic MRI .", "sentence_id": 4}
+{"abstract_id": "25481364", "label": "methods", "text": "For women randomized to hysterectomy , the exact uterine volume was based on histopathologic examination .", "sentence_id": 5}
+{"abstract_id": "25481364", "label": "methods", "text": "We compared the calculated volumes based on ultrasound parameters and estimated volume based on bimanual examination with either the calculated volumes of the pelvic MRI parameters or the calculated volume based on the exact weight during histological examinations .", "sentence_id": 6}
+{"abstract_id": "25481364", "label": "results", "text": "Our study demonstrated poor agreement between ultrasound and bimanual examination compared with exact volume during histopathologic examination and MRI-based volume .", "sentence_id": 7}
+{"abstract_id": "25481364", "label": "results", "text": "The agreement within the patient group with uterine volume > @ g and > @ g was fair to good .", "sentence_id": 8}
+{"abstract_id": "25481364", "label": "results", "text": "For those women with a uterine volume between @ and @ g , the agreement was poor when comparing bimanual estimates with volume obtained from MRI or histolopathologic examination .", "sentence_id": 9}
+{"abstract_id": "25481364", "label": "results", "text": "Within this volume group , the agreement on uterine volume between ultrasound and MRI or histopathologic examination was fair .", "sentence_id": 10}
+{"abstract_id": "25481364", "label": "conclusions", "text": "Our study shows that uterine volume as estimated by ultrasound and bimanual examination can be used for small or large uteri .", "sentence_id": 11}
+{"abstract_id": "25481364", "label": "conclusions", "text": "For uteri with an intermediate volume , bimanual examination and ultrasound are less reliable .", "sentence_id": 12}
+{"abstract_id": "24342495", "label": "background", "text": "To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation ( DIC ) , resulting in recovery from DIC and better outcomes in patients with sepsis , we conducted a prospective , randomized controlled multicenter trial at @ critical care centers in tertiary care hospitals .", "sentence_id": 0}
+{"abstract_id": "24342495", "label": "methods", "text": "We enrolled @ DIC patients with sepsis and antithrombin levels of @ to @ % in this study .", "sentence_id": 1}
+{"abstract_id": "24342495", "label": "methods", "text": "The participating patients were randomly assigned to an antithrombin arm receiving antithrombin at a dose of @IU/kg per day for three days or a control arm treated with no intervention .", "sentence_id": 2}
+{"abstract_id": "24342495", "label": "methods", "text": "The primary efficacy end point was recovery from DIC on day @ .", "sentence_id": 3}
+{"abstract_id": "24342495", "label": "methods", "text": "The analysis was conducted with an intention-to-treat approach .", "sentence_id": 4}
+{"abstract_id": "24342495", "label": "methods", "text": "DIC was diagnosed according to the Japanese Association for Acute Medicine ( JAAM ) scoring system .", "sentence_id": 5}
+{"abstract_id": "24342495", "label": "methods", "text": "The systemic inflammatory response syndrome ( SIRS ) score , platelet count and global markers of coagulation and fibrinolysis were measured on day @ and day @ .", "sentence_id": 6}
+{"abstract_id": "24342495", "label": "results", "text": "Antithrombin treatment resulted in significantly decreased DIC scores and better recovery rates from DIC compared with those observed in the control group on day @ .", "sentence_id": 7}
+{"abstract_id": "24342495", "label": "results", "text": "The incidence of minor bleeding complications did not increase , and no major bleeding related to antithrombin treatment was observed .", "sentence_id": 8}
+{"abstract_id": "24342495", "label": "results", "text": "The platelet count significantly increased ; however , antithrombin did not influence the sequential organ failure assessment ( SOFA ) score or markers of coagulation and fibrinolysis on day @ .", "sentence_id": 9}
+{"abstract_id": "24342495", "label": "conclusions", "text": "Moderate doses of antithrombin improve DIC scores , thereby increasing the recovery rate from DIC without any risk of bleeding in DIC patients with sepsis .", "sentence_id": 10}
+{"abstract_id": "24803644", "label": "objective", "text": "To investigate the effect of virtual reality ( VR ) rehabilitation on upper extremity motor performance of patients with early stroke .", "sentence_id": 0}
+{"abstract_id": "24803644", "label": "methods", "text": "Pilot randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24803644", "label": "methods", "text": "Rehabilitation wards .", "sentence_id": 2}
+{"abstract_id": "24803644", "label": "methods", "text": "Twenty three adults with stroke ( mean age ( SD ) = @ ( @ ) years and mean time since stroke ( SD ) = @ ( @ ) days ) .", "sentence_id": 3}
+{"abstract_id": "24803644", "label": "methods", "text": "Participants were randomly assigned to VR group ( n = @ ) or control group ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24803644", "label": "methods", "text": "VR group received nine @ minutes upper extremity VR therapy in standing ( five weekdays in two weeks ) plus conventional therapy , which included physical and occupational therapy .", "sentence_id": 5}
+{"abstract_id": "24803644", "label": "methods", "text": "Control group received only conventional therapy , which was comparable to total training time received by VR group ( mean training hours ( SD ) : VR = @ ( @ ) ; control = @ ( @ ) ) .", "sentence_id": 6}
+{"abstract_id": "24803644", "label": "methods", "text": "The main outcome measure was the Fugl-Meyer Assessment ( FMA ) .", "sentence_id": 7}
+{"abstract_id": "24803644", "label": "methods", "text": "Secondary outcomes included Action Research Arm Test , Motor Activity Log and Functional Independence Measure .", "sentence_id": 8}
+{"abstract_id": "24803644", "label": "methods", "text": "Results were taken at baseline , post intervention and @-month post intervention .", "sentence_id": 9}
+{"abstract_id": "24803644", "label": "methods", "text": "Participants ' feedback and adverse effects were recorded .", "sentence_id": 10}
+{"abstract_id": "24803644", "label": "results", "text": "All participants improved in FMA scores ( mean change ( SD ) = @ ( @ ) , P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24803644", "label": "results", "text": "These effects were sustained at one month after intervention ( mean ( SD ) change from baseline = @ ( @ ) , P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24803644", "label": "results", "text": "All other outcome measures showed similar patterns .", "sentence_id": 13}
+{"abstract_id": "24803644", "label": "results", "text": "There were no significant differences in improvement between both groups .", "sentence_id": 14}
+{"abstract_id": "24803644", "label": "results", "text": "Majority of the participants found VR training useful and enjoyable , with no serious adverse effects reported .", "sentence_id": 15}
+{"abstract_id": "24803644", "label": "conclusions", "text": "Although additional VR training was not superior to conventional therapy alone , this study demonstrates the feasibility of VR training in early stroke .", "sentence_id": 16}
+{"abstract_id": "25201887", "label": "background", "text": "n-@ fatty acids inhibit neuronal excitability and reduce seizures in animal models .", "sentence_id": 0}
+{"abstract_id": "25201887", "label": "background", "text": "High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results .", "sentence_id": 1}
+{"abstract_id": "25201887", "label": "background", "text": "We performed a phase II randomised controlled crossover trial of low-dose and high-dose fish oil in participants with drug resistant epilepsy to explore whether low-dose or high-dose fish oil reduces seizures or improves cardiovascular health .", "sentence_id": 2}
+{"abstract_id": "25201887", "label": "methods", "text": "Randomised placebo-controlled trial of low-dose and high-dose fish oil versus placebo ( corn oil , linoleic acid ) in @ participants with drug resistant epilepsy .", "sentence_id": 3}
+{"abstract_id": "25201887", "label": "methods", "text": "A three-period crossover design was utilised lasting @weeks , with three @-week treatment periods and two @-week washout periods .", "sentence_id": 4}
+{"abstract_id": "25201887", "label": "methods", "text": "All participants were randomised in double-blind fashion to receive placebo , high dose or low dose in different sequences .", "sentence_id": 5}
+{"abstract_id": "25201887", "label": "methods", "text": "The primary outcome was per cent change in total seizure frequency .", "sentence_id": 6}
+{"abstract_id": "25201887", "label": "results", "text": "Low-dose fish oil ( @ capsules/day , @mg eicosapentaenoic acid + docosahexaenoic acid ) was associated with a @ % reduction in seizure frequency compared with placebo .", "sentence_id": 7}
+{"abstract_id": "25201887", "label": "results", "text": "Low-dose fish oil was also associated with a mild but significant reduction in blood pressure .", "sentence_id": 8}
+{"abstract_id": "25201887", "label": "results", "text": "High-dose fish oil was no different than placebo in reducing seizures or improving cardiac risk factors .", "sentence_id": 9}
+{"abstract_id": "25201887", "label": "conclusions", "text": "In this phase II randomised crossover trial , low-dose fish oil was effective in reducing seizures compared with placebo .", "sentence_id": 10}
+{"abstract_id": "25201887", "label": "conclusions", "text": "The magnitude of improvement is similar to that of recent antiepileptic drug trials in drug resistant epilepsy ( DRE ) .", "sentence_id": 11}
+{"abstract_id": "25201887", "label": "conclusions", "text": "The results indicate that low-dose fish oil may reduce seizures and improve the health of people with epilepsy .", "sentence_id": 12}
+{"abstract_id": "25201887", "label": "conclusions", "text": "These findings justify a large multicentre randomised trial of low-dose fish oil ( n-@ fatty acids < @mg/day ) in drug resistant epilepsy .", "sentence_id": 13}
+{"abstract_id": "25140469", "label": "objective", "text": "To assess the patency of the pedicled right internal thoracic artery with an anteroaortic course and compare it to the patency of the left internal thoracic artery , in anastomosis to the left anterior descending artery in coronary artery bypass grafting by using coronary CT angiography at @ months postoperatively .", "sentence_id": 0}
+{"abstract_id": "25140469", "label": "methods", "text": "Between December @ and December @ , @ patients were selected to undergo a prospective coronary artery bypass grafting procedure without cardiopulmonary bypass .", "sentence_id": 1}
+{"abstract_id": "25140469", "label": "methods", "text": "The patients were randomly divided by a computer-generated list into Group-@ ( G-@ ) and Group-@ ( G-@ ) , comprising @ patients each , the technique used was known at the beginning of the surgery .", "sentence_id": 2}
+{"abstract_id": "25140469", "label": "methods", "text": "In G-@ , coronary artery bypass grafting was performed using the left internal thoracic artery for the left anterior descending and the free right internal thoracic artery for the circumflex , and in G-@ , coronary artery bypass grafting was performed using the right internal thoracic artery pedicled to the left anterior descending and the left internal thoracic artery pedicled to the circumflex territory .", "sentence_id": 3}
+{"abstract_id": "25140469", "label": "results", "text": "The groups were similar with regard to the preoperative clinical data .", "sentence_id": 4}
+{"abstract_id": "25140469", "label": "results", "text": "A male predominance of @ % and @ % was observed in G-@ and G-@ , respectively .", "sentence_id": 5}
+{"abstract_id": "25140469", "label": "results", "text": "Five patients migrated from G-@ to G-@ because of atheromatous disease in the ascending aorta .", "sentence_id": 6}
+{"abstract_id": "25140469", "label": "results", "text": "The average number of distal anastomoses was @ ( SD = @ ) in G-@ and @ ( SD = @ ) in G-@ .", "sentence_id": 7}
+{"abstract_id": "25140469", "label": "results", "text": "Coronary CT angiography in @ re-evaluated patients showed that all ITAs , right or left , used in situ for the left anterior descending were patent .", "sentence_id": 8}
+{"abstract_id": "25140469", "label": "results", "text": "There were no deaths in either group .", "sentence_id": 9}
+{"abstract_id": "25140469", "label": "conclusions", "text": "Coronary artery bypass grafting surgery involving anastomosis of the anteroaortic right internal thoracic artery to the left anterior descending artery has an outcome similar to that obtained using the left internal thoracic artery for the same coronary site .", "sentence_id": 10}
+{"abstract_id": "25301045", "label": "background", "text": "Dual-energy CT technology enables acquisition of virtual unenhanced ( VUE ) images from contrast-enhanced scans .", "sentence_id": 0}
+{"abstract_id": "25301045", "label": "objective", "text": "To assess the feasibility of coronary artery calcium ( CAC ) scoring on VUE images derived from fast kVp-switching dual-energy coronary CT angiography .", "sentence_id": 1}
+{"abstract_id": "25301045", "label": "methods", "text": "Twenty-seven patients underwent true noncontrast CAC-scoring CT followed by routine single-energy ( @-kVp ) and fast kVp-switching dual-energy coronary CT angiography , in a random acquisition order on the same day .", "sentence_id": 2}
+{"abstract_id": "25301045", "label": "methods", "text": "We calculated the CAC scores on true noncontrast and VUE images .", "sentence_id": 3}
+{"abstract_id": "25301045", "label": "methods", "text": "The image noises and the signal-to-noise and contrast-to-noise ratios of the aorta and coronary arteries were measured on both the single-energy coronary CT angiography images and dual-energy coronary CT angiography images ( @ keV virtual monochromatic spectral images ) .", "sentence_id": 4}
+{"abstract_id": "25301045", "label": "methods", "text": "The Pearson correlation coefficient test and paired t test were used for statistical analysis .", "sentence_id": 5}
+{"abstract_id": "25301045", "label": "results", "text": "Excellent correlation was observed between the CAC scores on the true noncontrast and those on the VUE images ( r = @ ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25301045", "label": "results", "text": "Compared with single-energy coronary CT angiography , dual-energy coronary CT angiography showed significantly reduced image noise and increased signal-to-noise and contrast-to-noise ratios in all regions ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25301045", "label": "results", "text": "The effective dose of dual-energy coronary CT angiography ( @ @ mSv ) was significantly lower than that of true noncontrast CAC-scoring CT plus single-energy coronary CT angiography ( @ @ mSv ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25301045", "label": "conclusions", "text": "Excellent correlation was observed between the CAC scores on the VUE images and true noncontrast images .", "sentence_id": 9}
+{"abstract_id": "25301045", "label": "conclusions", "text": "Thus , fast kVp-switching dual-energy coronary CT angiography could allow prediction of the true CAC scores , potentially reducing the total radiation exposure and image acquisition time by obviating the need for true noncontrast CAC-scoring CT. .", "sentence_id": 10}
+{"abstract_id": "25201459", "label": "objective", "text": "To evaluate the efficacy of tamsulosin therapy in reducing ureteral double-J stent morbidity by evaluating USSQ , IPSS , QOL and VAS ( primary objective ) and to evaluate the morbidity and or complication ( s ) associated with indwelling double-J ureteral stent ( s ) and to evaluate the safety of tamsulosin therapy for `` morbidity associated with double-J stents '' by evaluating its tolerability , side effects and adverse events if any ( secondary objective ) as per protocol .", "sentence_id": 0}
+{"abstract_id": "25201459", "label": "methods", "text": "After institutional review board approval , @ consecutive patients with a double-J ureteral stent inserted after percutaneous nephrolithotomy or ureteroscopic stone treatment were randomly assigned to receive tamsulosin @ mg , or a placebo for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25201459", "label": "methods", "text": "The validated USSQ , VAS and IPSS were completed before stent insertion , at @ days and @ weeks after stent insertion and at @ weeks after stent removal .", "sentence_id": 2}
+{"abstract_id": "25201459", "label": "methods", "text": "Data were statistically analyzed for efficacy and tolerability of one drug over the other using Wilcoxon signed-rank test , Mann-Whitney test and Student 's t test .", "sentence_id": 3}
+{"abstract_id": "25201459", "label": "results", "text": "Patients receiving tamsulosin compared with the placebo showed significant decrease in urinary index score , pain index score , work performance score , VAS score at loin area , VAS score at flank , VAS score at suprapubic area , average VAS score , need for antibiotics , number of hospital visits ( P < @ ) at the end of fourth weeks .", "sentence_id": 4}
+{"abstract_id": "25201459", "label": "results", "text": "Decrease in values were also observed in IPSS score , general health score , quality of sex score and IPSS-quality of life ( QOL ) score in patients taking tamsulosin but , however , the decrease was not significant .", "sentence_id": 5}
+{"abstract_id": "25201459", "label": "results", "text": "No patients discontinued medication because of side effects .", "sentence_id": 6}
+{"abstract_id": "25201459", "label": "conclusions", "text": "We conclude that ureteral stenting using double-J stents with concomitant tamsulosin therapy was generally well tolerated , safe , effective and significantly beneficial in reducing stent morbidity in the majority of our patients .", "sentence_id": 7}
+{"abstract_id": "25201459", "label": "conclusions", "text": "We advocate the routine use of concomitant tamsulosin therapy in eligible patients undergoing ureteral stenting in order to minimize stent morbidity .", "sentence_id": 8}
+{"abstract_id": "24439932", "label": "background", "text": "Parents of children with special needs are vigilant as their child may have difficulty independently escaping a burning home .", "sentence_id": 0}
+{"abstract_id": "24439932", "label": "background", "text": "The purpose of this study was to evaluate if providing home fire safety information via a digital video disc ( DVD ) increases families ' knowledge , behavior and ability regarding home fire safety .", "sentence_id": 1}
+{"abstract_id": "24439932", "label": "methods", "text": "A school based classroom intervention ( using a home fire safety DVD ) was provided to parents ( n = @ ) of children with and without special needs to improve home fire safety knowledge , behavior and ability .", "sentence_id": 2}
+{"abstract_id": "24439932", "label": "methods", "text": "In addition , parents seen at the Kentucky Commission for Children with Special Health Care Needs clinics ( n = @ ) received the same intervention in cohorts of @-@ children .", "sentence_id": 3}
+{"abstract_id": "24439932", "label": "methods", "text": "For both groups , knowledge , and behavior were measured before and after intervention .", "sentence_id": 4}
+{"abstract_id": "24439932", "label": "methods", "text": "Repeated measures ANOVA were used to test for differences between groups and over time .", "sentence_id": 5}
+{"abstract_id": "24439932", "label": "methods", "text": "Significance was set at p < @ .", "sentence_id": 6}
+{"abstract_id": "24439932", "label": "results", "text": "No difference in scores between pre - and post-test scores existed between groups ( with special needs vs. without special needs , or classroom vs. individualized instruction ) .", "sentence_id": 7}
+{"abstract_id": "24439932", "label": "results", "text": "However , some differences were noted for some individual survey questions during post-hoc comparisons .", "sentence_id": 8}
+{"abstract_id": "24439932", "label": "results", "text": "Having a smoke alarm in the home ( @ % vs. @ % , p = @ ) and having a smoke alarm outside of where everyone sleeps ( @ % vs. @ % , p = @ ) increased over time and was retained .", "sentence_id": 9}
+{"abstract_id": "24439932", "label": "results", "text": "Having a fire escape plan increased at post intervention ( @ % vs. @ % , p = @ ) , but returned to pre levels at follow-up ( @ % ) .", "sentence_id": 10}
+{"abstract_id": "24439932", "label": "results", "text": "Perceived knowledge ( @ vs. @ , p < @ ) and ability ( @ vs. @ , p = @ ) increased over time .", "sentence_id": 11}
+{"abstract_id": "24439932", "label": "conclusions", "text": "Parents of children with special needs had a significant increase in knowledge and behavior over those parents of children without special needs .", "sentence_id": 12}
+{"abstract_id": "24439932", "label": "conclusions", "text": "They also perceived having a high fire safety ability .", "sentence_id": 13}
+{"abstract_id": "24439932", "label": "conclusions", "text": "Many of the post-test questions/behaviors ( e.g. , capable of exiting home during a fire , etc. ) were reported at @ % .", "sentence_id": 14}
+{"abstract_id": "24439932", "label": "conclusions", "text": "The intervention was well received , but may not necessarily be needed .", "sentence_id": 15}
+{"abstract_id": "24439932", "label": "conclusions", "text": "Focus for home fire safety may need to look at younger children and smaller families .", "sentence_id": 16}
+{"abstract_id": "24439932", "label": "conclusions", "text": "Parents of special needs children may have had frequent interaction with health care professionals .", "sentence_id": 17}
+{"abstract_id": "24996223", "label": "background", "text": "To compare pain response outcomes for patients with spinal bone metastases treated with resistance training of the spinal musculature versus passive physical therapy during radiotherapy ( RT ) .", "sentence_id": 0}
+{"abstract_id": "24996223", "label": "methods", "text": "In this randomized trial , @ consecutive patients were treated from September @ until March @ within one of the two groups : resistance training ( Arm A ) or passive physical therapy ( Arm B ) with thirty patients in each group during RT. .", "sentence_id": 1}
+{"abstract_id": "24996223", "label": "methods", "text": "The course of pain according to visual analog scale ( VAS ) , concurrent medication , and oral morphine equivalent dose ( OMED ) were assessed at baseline , three months , and six months after RT. .", "sentence_id": 2}
+{"abstract_id": "24996223", "label": "methods", "text": "Pain response was determined using International Bone Consensus response definitions .", "sentence_id": 3}
+{"abstract_id": "24996223", "label": "results", "text": "The course of VAS in the intervention group ( Arm A ) was significantly lower both during and after RT ( AUC , p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24996223", "label": "results", "text": "The use of analgetic medication showed the same result , with significantly fewer analgetics being necessary both during and after RT in arm A ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24996223", "label": "results", "text": "In the course of time , the OMED decreased in arm A , but increased in arm B.", "sentence_id": 6}
+{"abstract_id": "24996223", "label": "results", "text": "After @ month , @ % of patients in arm A , and @ % in arm B were responders ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24996223", "label": "conclusions", "text": "Our trial demonstrated that guided isometric resistance training of the paravertebral muscles can improve pain relief over a @-months period in patients with stable spinal metastases .", "sentence_id": 8}
+{"abstract_id": "24996223", "label": "conclusions", "text": "Importantly , the intervention was able to reduce OMED as well as concomitant pain medication .", "sentence_id": 9}
+{"abstract_id": "24996223", "label": "conclusions", "text": "The trial is registered in Clinical trial identifier NCT @ ( http://www.clinicaltrials.gov/ ) since @nd of August @ .", "sentence_id": 10}
+{"abstract_id": "25511354", "label": "objective", "text": "Prostate cancer is a major public health issue .", "sentence_id": 0}
+{"abstract_id": "25511354", "label": "objective", "text": "Its incidence is rising , especially in Nigeria .", "sentence_id": 1}
+{"abstract_id": "25511354", "label": "objective", "text": "Prompt diagnosis is necessary by histology .", "sentence_id": 2}
+{"abstract_id": "25511354", "label": "objective", "text": "Transperineal and transrectal approaches to prostate biopsy are well-documented .", "sentence_id": 3}
+{"abstract_id": "25511354", "label": "objective", "text": "Both methods are fraught with complications though , most times minor .", "sentence_id": 4}
+{"abstract_id": "25511354", "label": "objective", "text": "Studies carried out to compare both methods were carried out mainly on Caucasians , generating conflicting results .", "sentence_id": 5}
+{"abstract_id": "25511354", "label": "objective", "text": "This study aims to compare the complication rates and tissue yield of these two methods in Nigerian men .", "sentence_id": 6}
+{"abstract_id": "25511354", "label": "methods", "text": "Seventy-five patients completed the study .", "sentence_id": 7}
+{"abstract_id": "25511354", "label": "methods", "text": "Forty-five patients had transperineal prostate biopsy ( TPbx ) , while @ patients had transrectal prostate biopsy .", "sentence_id": 8}
+{"abstract_id": "25511354", "label": "methods", "text": "Pain perception for all patients was determined by visual analog scale ; whereas the complications were ascertained by a validated purpose designed questionnaire administered on the @ th and @ th day post operatively .", "sentence_id": 9}
+{"abstract_id": "25511354", "label": "results", "text": "The risk of rectal bleeding was higher for transrectal prostate biopsy compared to transperineal ( Odds ratio : @ ; @ % confidence interval ( CI ) : @-@ @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25511354", "label": "results", "text": "TPbx was more painful than transrectal ( P < @ ; df : @ ; t : @ ; @ % CI of difference in mean : -@ - -LSB- -@ -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "25511354", "label": "results", "text": "There was no statistical difference between transperineal and transrectal prostate biopsy in hemospermia , fever , prostatic abscess , urethral bleeding , acute retention and tissue yield .", "sentence_id": 12}
+{"abstract_id": "25511354", "label": "conclusions", "text": "TPbx is more painful than transrectal prostate biopsy though with a significantly reduced risk of rectal bleeding .", "sentence_id": 13}
+{"abstract_id": "25511354", "label": "conclusions", "text": "There appears to be no significant difference with respect to risk of fever , urethral bleeding , hematospermia , prostatic abscess and acute retention .", "sentence_id": 14}
+{"abstract_id": "25511354", "label": "conclusions", "text": "Both routes provided sufficient prostate tissue for histology .", "sentence_id": 15}
+{"abstract_id": "24912899", "label": "objective", "text": "To document the rate and outcome of trastuzumab-associated cardiac dysfunction in patients following @ or @ years of adjuvant therapy .", "sentence_id": 0}
+{"abstract_id": "24912899", "label": "methods", "text": "The Herceptin Adjuvant ( HERA ) trial is a three-arm , randomized trial comparing @ years or @ year of trastuzumab with observation in @,@ patients with human epidermal growth factor receptor @ ( HER@ ) - positive early-stage breast cancer .", "sentence_id": 1}
+{"abstract_id": "24912899", "label": "methods", "text": "Cardiac function was closely monitored .", "sentence_id": 2}
+{"abstract_id": "24912899", "label": "methods", "text": "Eligible patients had left ventricular ejection fraction ( LVEF ) @ % at study entry following neoadjuvant chemotherapy with or without radiotherapy .", "sentence_id": 3}
+{"abstract_id": "24912899", "label": "methods", "text": "This @-year median follow-up analysis considered patients randomly assigned to @ years or @ year of trastuzumab or observation .", "sentence_id": 4}
+{"abstract_id": "24912899", "label": "results", "text": "The as-treated safety population for @ years of trastuzumab ( n = @,@ ) , @ year of trastuzumab ( n = @,@ ) , and observation ( n = @,@ ) is reported .", "sentence_id": 5}
+{"abstract_id": "24912899", "label": "results", "text": "Cardiac adverse events leading to discontinuation of trastuzumab occurred in @ % of patients in the @-year arm and @ % of patients in the @-year arm .", "sentence_id": 6}
+{"abstract_id": "24912899", "label": "results", "text": "Cardiac death , severe congestive heart failure ( CHF ) , and confirmed significant LVEF decrease remained low in all three arms .", "sentence_id": 7}
+{"abstract_id": "24912899", "label": "results", "text": "The incidence of severe CHF ( @ % , @ % , and @ % , respectively ) and confirmed significant LVEF decrease ( @ % , @ % , and @ % , respectively ) was significantly higher in the @-year and @-year trastuzumab arms compared with the observation arm .", "sentence_id": 8}
+{"abstract_id": "24912899", "label": "results", "text": "Severe CHF was the same for @-year and @-year trastuzumab .", "sentence_id": 9}
+{"abstract_id": "24912899", "label": "results", "text": "Of patients with confirmed LVEF decrease receiving @-year trastuzumab , @ % reached acute recovery .", "sentence_id": 10}
+{"abstract_id": "24912899", "label": "results", "text": "Of patients with confirmed LVEF decrease receiving @-year trastuzumab , @ % reached acute recovery .", "sentence_id": 11}
+{"abstract_id": "24912899", "label": "conclusions", "text": "Long-term assessment at @-year median follow-up confirms the low incidence of cardiac events for trastuzumab given sequentially after chemotherapy and radiotherapy , and cardiac events were reversible in the vast majority of patients .", "sentence_id": 12}
+{"abstract_id": "24981311", "label": "background", "text": "Combination of fluoropyrimidines and a platinum derivative are currently standards for systemic chemotherapy in advanced adenocarcinoma of the stomach and gastroesophageal junction ( GEJ ) .", "sentence_id": 0}
+{"abstract_id": "24981311", "label": "background", "text": "Nevertheless , individual likelihood for response to these therapeutic regimes remains uncertain .", "sentence_id": 1}
+{"abstract_id": "24981311", "label": "background", "text": "Even more , no predictive markers are available to determine which patients may benefit more from oxaliplatin versus cisplatin or vice versa .", "sentence_id": 2}
+{"abstract_id": "24981311", "label": "background", "text": "The new invasion and stem cell markers VEGFR-@ and CXCR@ have been linked prognostically with more aggressive esophagogastric cancer types .", "sentence_id": 3}
+{"abstract_id": "24981311", "label": "background", "text": "Thus , we aimed to assess correlations of VEGFR-@ and CXCR@ expression levels with clinical outcome in a randomized phase III study of patients with oxaliplatin/leucovorin/@-FU ( FLO ) versus cisplatin/leucovorin/@-FU ( FLP ) .", "sentence_id": 4}
+{"abstract_id": "24981311", "label": "methods", "text": "The patients data examined in this study ( n = @ ) were from the collective of the FLO vs. FLP phase III AIO trial .", "sentence_id": 5}
+{"abstract_id": "24981311", "label": "methods", "text": "Tumour tissues were stained via immunohistochemistry for VEGFR-@ and CXCR@ expression and results were evaluated by two independent , blinded investigators.Outcome parameter : Survival analysis was calculated for patients receiving FLO vs. FLP in relation to VEGFR-@ and CXCR@ expression .", "sentence_id": 6}
+{"abstract_id": "24981311", "label": "results", "text": "@ % and @ % of the examined tumour tissues showed strong positive expression of VEGFR-@ and CXCR@ respectively .", "sentence_id": 7}
+{"abstract_id": "24981311", "label": "results", "text": "No superiority of each regime was detected in terms of overall survival ( OS ) in the whole population .", "sentence_id": 8}
+{"abstract_id": "24981311", "label": "results", "text": "Patients with strong expression of CXCR@ on their tumour tissues profited more in terms of OS under the treatment of FLP ( mOS : @ vs @ months , p = @ respectively ) .", "sentence_id": 9}
+{"abstract_id": "24981311", "label": "results", "text": "Patients with negative VEGFR-@ and CXCR@ expression had a trend to live longer when FLO regime was applied ( mOS : @ vs. @ months , p = @ and @ vs. @ months , p = @ respectively ) .", "sentence_id": 10}
+{"abstract_id": "24981311", "label": "results", "text": "In an exploratory analysis of patients older than @ years at diagnosis , we observed a significant benefit in overall survival for VEGFR-@ and CXCR@-positive patients when treated with FLP ( p = @ , p = @ respectively ) .", "sentence_id": 11}
+{"abstract_id": "24981311", "label": "conclusions", "text": "CXCR@ positive patients profited in terms of OS from FLP , whereas FLO proved to be more effective in CXCR@ and VEGFR-@ negative patients .", "sentence_id": 12}
+{"abstract_id": "24981311", "label": "conclusions", "text": "Our results suggest , despite the limited size of the study , a predictive value of these biomarkers concerning chemotherapy with FLP or FLO in advanced esophagogastric cancer .", "sentence_id": 13}
+{"abstract_id": "25408387", "label": "objective", "text": "The aim of this study was to investigate the significance of the combined use of BMI and AEC in reducing the radiation dose of CT volume scans of the lumbar spine .", "sentence_id": 0}
+{"abstract_id": "25408387", "label": "methods", "text": "A prospective study was performed to continuously collect data from @ patients ( age range from @ to @ years , male versus female @/@ ) whose BMIs were less than @ kg/m <formula> ^ -LCB- @ -RCB- </formula> ( group A ) and @ patients ( age range from @ to @ years , male versus female @/@ ) whose BMIs were equal to or more than @ kg/m <formula> ^ -LCB- @ -RCB- </formula> ( group B ) .", "sentence_id": 1}
+{"abstract_id": "25408387", "label": "methods", "text": "The @ patients in each group were randomly divided into @ subgroups with each subgroup having lower radiation dose from subgroup @ to @ .", "sentence_id": 2}
+{"abstract_id": "25408387", "label": "methods", "text": "All the patients were performed lumbar spiral CT scans ( GE LightSpeed VCT @-slice scanner ) and the scan parameters were different in different subgroups .", "sentence_id": 3}
+{"abstract_id": "25408387", "label": "methods", "text": "Volume CT dose index ( CTDIvol ) was recorded .", "sentence_id": 4}
+{"abstract_id": "25408387", "label": "methods", "text": "The qualities of the images were graded .", "sentence_id": 5}
+{"abstract_id": "25408387", "label": "methods", "text": "The one-way ANOVA and Kruskal-Wallis test were done .", "sentence_id": 6}
+{"abstract_id": "25408387", "label": "results", "text": "Both in group A and B , there were significant differences in CTDIvol among the @ subgroups ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25408387", "label": "results", "text": "The quality of the images in the @ subgroups of group A did n't show statistical difference .", "sentence_id": 8}
+{"abstract_id": "25408387", "label": "results", "text": "The standard deviation ( SD ) and signal to noise ratio ( SNR ) values of the L@-@ psoas major muscles in subgroup @ of group B was statistical different from the other @ subgroups ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25408387", "label": "conclusions", "text": "Use of BMI combined with AEC reduces radiation dosage , without compromising the image quality .", "sentence_id": 10}
+{"abstract_id": "25408387", "label": "conclusions", "text": "For patients in group A and group B , parameters of subgroup @ and subgroup @ may respectively be applied for lower dose CT scanning .", "sentence_id": 11}
+{"abstract_id": "24924216", "label": "objective", "text": "To evaluate the distribution and extent of myocardial fibrosis identified by either contrast-enhanced Look-Locker or late gadolinium enhancement magnetic resonance imaging ( LGE MRI ) and their relationships between ventricular tachyarrhythmia or risk factors in apical hypertrophic cardiomyopathy ( APH ) .", "sentence_id": 0}
+{"abstract_id": "24924216", "label": "methods", "text": "Twenty-five APH patients were examined using a @ T or @ T instrument .", "sentence_id": 1}
+{"abstract_id": "24924216", "label": "methods", "text": "We used MRI to evaluate myocardial T@ values and scar .", "sentence_id": 2}
+{"abstract_id": "24924216", "label": "methods", "text": "We compared the myocardial fibrosis assessed by contrast-enhanced Look-Locker or LGE MRI with ventricular tachyarrhythmia or risk factors for hypertrophic cardiomyopathy .", "sentence_id": 3}
+{"abstract_id": "24924216", "label": "results", "text": "Myocardial scar was present in @ of the @ patients with APH .", "sentence_id": 4}
+{"abstract_id": "24924216", "label": "results", "text": "Myocardial scar was distributed predominantly in the apical myocardium ( P < @ ) , whereas myocardial T@ values did not differ between the apical , midventricular , and basal septum .", "sentence_id": 5}
+{"abstract_id": "24924216", "label": "results", "text": "The extent of myocardial scar according to @-segment model and ejection fraction were related to ventricular tachyarrhythmia or risk factors in APH ( P < @ for both ) .", "sentence_id": 6}
+{"abstract_id": "24924216", "label": "results", "text": "The myocardial T@ value was not associated with the tachyarrhythmia or risk factors .", "sentence_id": 7}
+{"abstract_id": "24924216", "label": "conclusions", "text": "In APH , the extent of myocardial scar on LGE MRI is associated with ventricular tachyarrhythmia and risk factors .", "sentence_id": 8}
+{"abstract_id": "24924216", "label": "conclusions", "text": "Quantification of the myocardial T@ value is not necessary for its risk stratification .", "sentence_id": 9}
+{"abstract_id": "25876346", "label": "objective", "text": "To compare the difference in clinical efficacy on children attention deficit hyperactivity disorder ( ADHD ) between the combined therapy of scalp acupuncture and EGG biofeedback and the simple EEG biofeedback therapy so as to search the better therapeutic method for ADHD .", "sentence_id": 0}
+{"abstract_id": "25876346", "label": "methods", "text": "One hundred patients were randomized into an observation group and a control group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25876346", "label": "methods", "text": "In the control group , the simple EEG biofeedback therapy was adopted .", "sentence_id": 2}
+{"abstract_id": "25876346", "label": "methods", "text": "In the observation group , on the basis of biofeedback therapy , scalp acupuncture was added and applied to Dingzhongxian ( MS @ ) , Dingpangyixian ( MS @ ) , Baihui ( GV @ ) , Sishencong ( EX-HN @ ) , etc. .", "sentence_id": 3}
+{"abstract_id": "25876346", "label": "methods", "text": "The ten treatments made one session .", "sentence_id": 4}
+{"abstract_id": "25876346", "label": "methods", "text": "After four sessions of treatment , FIQ value in Wechsler intelligence scale , CIH score in Conners children behavior questionnaire , the ratio of @ wave and p wave in EEG , FRCQ and FAQ in the integrated visual and auditory continuous performance test ( IVA-CPT ) and clinical comprehensive efficacy were observed before and after treatment in the two groups separately .", "sentence_id": 5}
+{"abstract_id": "25876346", "label": "results", "text": "Three cases were dropped out in the observation group and @ cases were out in the control group .", "sentence_id": 6}
+{"abstract_id": "25876346", "label": "results", "text": "In the two groups , FIQ , FRCQ and FAQ were all increased after treatment ( P < @ , P < @ ) ; the increases in the observation group were much more significant than those in the control group after treatment ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25876346", "label": "results", "text": "In the two groups , CIH score and the ratio of @ wave and p wave were all reduced after treatment ( P < @ , P < @ ) ; the reduction in the observation group were much more apparent as compared with those in the control group ( both P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25876346", "label": "results", "text": "The total effective rate was @ % ( @/@ ) in the observation group and better than @ % ( @/@ , P < @ ) in the control group .", "sentence_id": 9}
+{"abstract_id": "25876346", "label": "conclusions", "text": "The combined therapy of scalp acupuncture and EEG biofeedback achieves the superior efficacy on children ADHD as compared with the simple biofeedback therapy .", "sentence_id": 10}
+{"abstract_id": "25876346", "label": "conclusions", "text": "This combined therapy rapidly relieves the essential symptoms of ADHD and improves EEG waveform in children patients .", "sentence_id": 11}
+{"abstract_id": "25876346", "label": "conclusions", "text": "Importantly , this therapy obtains and consolidates the significant efficacy .", "sentence_id": 12}
+{"abstract_id": "25267748", "label": "objective", "text": "Although p@ protein expression , a surrogate marker of oncogenic human papillomavirus ( HPV ) infection , is recognized as a prognostic marker in oropharyngeal squamous cell carcinoma ( OPSCC ) , its prevalence and significance have not been well established in cancer of the oral cavity , hypopharynx , or larynx , collectively referred as non-OPSCC , where HPV infection is less common than in the oropharynx .", "sentence_id": 0}
+{"abstract_id": "25267748", "label": "methods", "text": "p@ expression and high-risk HPV status in non-OPSCCs from RTOG @ , @ , and @ studies were determined by immunohistochemistry ( IHC ) and in situ hybridization ( ISH ) .", "sentence_id": 1}
+{"abstract_id": "25267748", "label": "methods", "text": "Hazard ratios from Cox models were expressed as positive or negative , stratified by trial , and adjusted for clinical characteristics .", "sentence_id": 2}
+{"abstract_id": "25267748", "label": "results", "text": "p@ expression was positive in @ % ( @ of @ ) , @ % ( @ of @ ) , and @ % ( @ of @ ) and HPV ISH was positive in @ % ( six of @ ) , @ % ( @ of @ ) , and @ % ( seven of @ ) of non-OPSCCs from RTOG @ , @ , and @ studies , respectively .", "sentence_id": 3}
+{"abstract_id": "25267748", "label": "results", "text": "Hazard ratios for p@ expression were @ ( @ % CI , @ to @ ; P = @ ) and @ ( @ % CI , @ to @ ; P = @ ) for progression-free ( PFS ) and overall survival ( OS ) , respectively .", "sentence_id": 4}
+{"abstract_id": "25267748", "label": "results", "text": "Comparing OPSCC and non-OPSCC , patients with p@-positive OPSCC have better PFS and OS than patients with p@-positive non-OPSCC , but patients with p@-negative OPSCC and non-OPSCC have similar outcomes .", "sentence_id": 5}
+{"abstract_id": "25267748", "label": "conclusions", "text": "Similar to results in patients with OPSCC , patients with p@-negative non-OPSCC have worse outcomes than patients with p@-positive non-OPSCC , and HPV may also have a role in outcome in a subset of non-OPSCC .", "sentence_id": 6}
+{"abstract_id": "25267748", "label": "conclusions", "text": "However , further development of a p@ IHC scoring system in non-OPSCC and improvement of HPV detection methods are warranted before broad application in the clinical setting .", "sentence_id": 7}
+{"abstract_id": "25007225", "label": "background", "text": "Fatigue and emotional reactivity are common among women suffering from breast cancer and might detrimentally affect these women 's quality of life .", "sentence_id": 0}
+{"abstract_id": "25007225", "label": "background", "text": "This study evaluates if the stress management delivered either in a group or individual setting would improve fatigue and emotional reactivity among women with a newly diagnosed breast cancer .", "sentence_id": 1}
+{"abstract_id": "25007225", "label": "methods", "text": "Participants ( n = @ ) who reported elevated levels of distress at three-month post-inclusion were randomised between stress management in a group ( GSM ) ( n = @ ) or individual ( ISM ) ( n = @ ) setting .", "sentence_id": 2}
+{"abstract_id": "25007225", "label": "methods", "text": "Participation was declined by @ women .", "sentence_id": 3}
+{"abstract_id": "25007225", "label": "methods", "text": "Participants completed the Multidimensional Fatigue Inventory ( MFI-@ ) and the Everyday Life Stress Scale ( ELSS ) at the time of inclusion , @ - and @-month post-inclusion .", "sentence_id": 4}
+{"abstract_id": "25007225", "label": "methods", "text": "Analyses were made according to intention to treat and per-protocol principles .", "sentence_id": 5}
+{"abstract_id": "25007225", "label": "methods", "text": "Mann-Whitney tests were used to examine differences between the two intervention groups .", "sentence_id": 6}
+{"abstract_id": "25007225", "label": "results", "text": "No significant differences were detected between the GSM and ISM groups on fatigue or emotional reactivity .", "sentence_id": 7}
+{"abstract_id": "25007225", "label": "results", "text": "In addition , there were no changes over time for these outcomes .", "sentence_id": 8}
+{"abstract_id": "25007225", "label": "conclusions", "text": "There were no differences between the two intervention arms with reference to fatigue or emotional reactivity ; however , a clinically interesting finding was the low number of women who were interested in participating in a psychosocial intervention .", "sentence_id": 9}
+{"abstract_id": "25007225", "label": "conclusions", "text": "This finding may have clinical implications when psychosocial support is offered to women with a newly diagnosed breast cancer and also in the planning of future studies .", "sentence_id": 10}
+{"abstract_id": "25636519", "label": "objective", "text": "To improve the quality of chest compression ( CC ) , we developed the assistant-push method , whereby the second rescuer pushes the back of the chest compressor during CC .", "sentence_id": 0}
+{"abstract_id": "25636519", "label": "objective", "text": "We investigated the effectiveness and feasibility of assistant push in achieving and maintaining the CC quality .", "sentence_id": 1}
+{"abstract_id": "25636519", "label": "methods", "text": "This was a randomized crossover trial in which @ subjects randomly performed both of standard CC ( single-rescuer group ) and CC with instructor-driven assistant push ( assistant-push group ) in different order .", "sentence_id": 2}
+{"abstract_id": "25636519", "label": "methods", "text": "Each session of CC was performed for @ minutes using a manikin .", "sentence_id": 3}
+{"abstract_id": "25636519", "label": "methods", "text": "Subjects were also assigned to both roles of chest compressor and assistant and together performed CC with subject-driven assistant push .", "sentence_id": 4}
+{"abstract_id": "25636519", "label": "methods", "text": "Depth of CC , compression to recoil ratio , duty cycle , and rate of incomplete recoil were quantified .", "sentence_id": 5}
+{"abstract_id": "25636519", "label": "results", "text": "The mean depth of CC ( @ -LSB- @-@ @ -RSB- vs @ -LSB- @-@ @ -RSB- , P < @ ) was significantly deeper , and the compression force ( @ -LSB- @-@ @ -RSB- vs @ -LSB- @-@ @ -RSB- , P < @ ) was stronger in the assistant-push group .", "sentence_id": 6}
+{"abstract_id": "25636519", "label": "results", "text": "The ratio of compression to recoil , duty cycle , and rate of incomplete chest recoil were comparable between the @ groups .", "sentence_id": 7}
+{"abstract_id": "25636519", "label": "results", "text": "The CC depth in the single-rescuer group decreased significantly every @ seconds , whereas in the assistant-push group , it was comparable at @ - and @-second time points ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25636519", "label": "results", "text": "The subject assistant-push group performed CCs at a depth comparable with that of the instructor assistant-push group .", "sentence_id": 9}
+{"abstract_id": "25636519", "label": "conclusions", "text": "The assistant-push method improved the depth of CC and attenuated its decline , eventually helping maintain adequate CC depth over time .", "sentence_id": 10}
+{"abstract_id": "25636519", "label": "conclusions", "text": "Subjects were able to feasibly learn assistant push and performed effectively .", "sentence_id": 11}
+{"abstract_id": "25713888", "label": "background", "text": "Midodrine is an - agonist prodrug of desglymidodrine used for the management of hypotension .", "sentence_id": 0}
+{"abstract_id": "25713888", "label": "background", "text": "Midodrine has demonstrated usefulness in hepatorenal syndrome .", "sentence_id": 1}
+{"abstract_id": "25713888", "label": "objective", "text": "The objective of the present work was to study the role of midodrine in patients with non-azotemic cirrhosis with tense ascites .", "sentence_id": 2}
+{"abstract_id": "25713888", "label": "methods", "text": "This prospective randomized double blind placebo-controlled study was conducted on @ non azotemic inpatients with liver cirrhosis and tense ascites ( @ men and @ women ; age range , @-@ ) .", "sentence_id": 3}
+{"abstract_id": "25713888", "label": "methods", "text": "One patient declined to participate in the study , @ patients were randomly assigned to take midodrine hydrochloride , and @ patients were randomly assigned to take placebo .", "sentence_id": 4}
+{"abstract_id": "25713888", "label": "methods", "text": "Out of @ enrolled patients , @ patients ( @ : in midodrine group ; @ : in placebo group ) completed the study and @ patients lost to follow up .", "sentence_id": 5}
+{"abstract_id": "25713888", "label": "methods", "text": "Patients were assessed for patients characteristics , history of tapping their ascetic fluid , laboratory values , and Doppler parameters before and after the study .", "sentence_id": 6}
+{"abstract_id": "25713888", "label": "methods", "text": "Average @-h urine volume was assessed before and after the start of the study .", "sentence_id": 7}
+{"abstract_id": "25713888", "label": "results", "text": "significant reduction in body weight and abdominal girth was observed after @ weeks of midodrine therapy .", "sentence_id": 8}
+{"abstract_id": "25713888", "label": "conclusions", "text": "Midodrine appeared to be effective in lowering body weights and abdominal girths of non azotemic cirrhotic patients with tense ascites .", "sentence_id": 9}
+{"abstract_id": "24833235", "label": "background", "text": "Antiarrhythmic drugs ( AADs ) and anticoagulation are mainstays of atrial fibrillation ( AF ) treatment .", "sentence_id": 0}
+{"abstract_id": "24833235", "label": "objective", "text": "To study the use and outcomes of AAD therapy in anticoagulated patients with AF .", "sentence_id": 1}
+{"abstract_id": "24833235", "label": "methods", "text": "Patients in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation trial ( N = @,@ ) were stratified by AAD use at baseline : amiodarone , other AAD , or no AAD .", "sentence_id": 2}
+{"abstract_id": "24833235", "label": "methods", "text": "Multivariable adjustment was performed to compare stroke , bleeding , and death across AAD groups as well as across treatment assignment ( rivaroxaban or warfarin ) .", "sentence_id": 3}
+{"abstract_id": "24833235", "label": "results", "text": "Of @,@ patients randomized , @ ( @ % ) were treated with an AAD ( @ -LSB- @ % -RSB- with amiodarone and @ -LSB- @ % -RSB- with other AADs ) .", "sentence_id": 4}
+{"abstract_id": "24833235", "label": "results", "text": "Amiodarone-treated patients were less often female ( @ % vs @ % ) , had more persistent AF ( @ % vs @ % ) , and more concomitant heart failure ( @ % vs @ % ) than were patients receiving other AADs .", "sentence_id": 5}
+{"abstract_id": "24833235", "label": "results", "text": "Patients receiving no AAD more closely resembled amiodarone-treated patients .", "sentence_id": 6}
+{"abstract_id": "24833235", "label": "results", "text": "Time in therapeutic range was significantly lower in warfarin-treated patients receiving amiodarone than in those receiving no AAD ( @ % vs @ % ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24833235", "label": "results", "text": "Compared with no AAD , neither amiodarone ( adjusted hazard ratio -LSB- HR -RSB- @ ; @ % confidence interval -LSB- CI -RSB- @-@ @ ; P = @ ) nor other AADs ( adjusted HR @ ; @ % CI @-@ @ ; P = @ ) were associated with increased mortality .", "sentence_id": 8}
+{"abstract_id": "24833235", "label": "results", "text": "Similar results were observed for embolic and bleeding outcomes .", "sentence_id": 9}
+{"abstract_id": "24833235", "label": "results", "text": "Treatment effects of rivaroxaban vs warfarin in patients receiving no AAD were consistent with results from the overall trial ( primary end point : adjusted HR @ ; @ % CI @-@ @ ; Pinteraction = @ ; safety end point : adjusted HR @ ; @ % CI @-@ @ ; Pinteraction = @ ) .", "sentence_id": 10}
+{"abstract_id": "24833235", "label": "conclusions", "text": "Treatment with AADs was not associated with increased morbidity or mortality in anticoagulated patients with AF .", "sentence_id": 11}
+{"abstract_id": "24833235", "label": "conclusions", "text": "The effect of amiodarone on outcomes in patients receiving rivaroxaban requires further investigation .", "sentence_id": 12}
+{"abstract_id": "25819856", "label": "background", "text": "Mental stress-induced myocardial ischemia ( MSIMI ) is common in patients with ischemic heart disease ( IHD ) and associated with a poorer cardiovascular prognosis .", "sentence_id": 0}
+{"abstract_id": "25819856", "label": "background", "text": "Platelet hyperactivity is an important factor in acute coronary syndrome .", "sentence_id": 1}
+{"abstract_id": "25819856", "label": "background", "text": "This study examined associations between MSIMI and resting and mental stress-induced platelet activity .", "sentence_id": 2}
+{"abstract_id": "25819856", "label": "methods", "text": "Eligible patients with clinically stable IHD underwent a battery of @ mental stress tests during the recruitment phase of REMIT study .", "sentence_id": 3}
+{"abstract_id": "25819856", "label": "methods", "text": "MSIMI was assessed by echocardiography and electrocardiography .", "sentence_id": 4}
+{"abstract_id": "25819856", "label": "methods", "text": "Ex vivo platelet aggregation in response to ADP , epinephrine , collagen , serotonin , and combinations of serotonin plus ADP , epinephrine , and collagen were evaluated as was platelet serotonin transporter expression .", "sentence_id": 5}
+{"abstract_id": "25819856", "label": "results", "text": "Of the @ participants who completed mental stress testing , and had both resting and post-stress platelet aggregation evaluation , @ % ( n = @ ) met criteria for MSIMI and @ % ( n = @ ) had normal left ventricular response to stress ( NLVR ) .", "sentence_id": 6}
+{"abstract_id": "25819856", "label": "results", "text": "The MSIMI group , relative to the NLVR groups , demonstrated heightened mental stress-induced aggregation responses , as measured by area under the curve , to collagen @M ( @ -LSB- @ -RSB- vs. -@ -LSB- @ -RSB- .", "sentence_id": 7}
+{"abstract_id": "25819856", "label": "results", "text": "; P = @ ) , epinephrine @M ( @ -LSB- @ -RSB- vs. -@ -LSB- @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "25819856", "label": "results", "text": "; P = @ ) and to serotonin @ M plus ADP @ M ( @ -LSB- @ -RSB- vs. -@ -LSB- @ -RSB- ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25819856", "label": "results", "text": "The resting platelet aggregation and serotonin transporter expression , however , were not different between the two groups .", "sentence_id": 10}
+{"abstract_id": "25819856", "label": "conclusions", "text": "These findings suggest that the dynamic change of platelet aggregation caused by mental stress may underlie MSIMI .", "sentence_id": 11}
+{"abstract_id": "25819856", "label": "conclusions", "text": "While the importance of these findings requires additional investigation , they raise concern given the recognized relationship between mental stress-induced platelet hyperactivity and cardiovascular events in patients with IHD .", "sentence_id": 12}
+{"abstract_id": "25340383", "label": "background", "text": "Surgical and medical treatments for emphysema may affect both quality and quantity of life .", "sentence_id": 0}
+{"abstract_id": "25340383", "label": "background", "text": "The purpose of this article is to report outcomes from the National Emphysema Treatment Trial ( NETT ) using an index that combines quality and quantity of life .", "sentence_id": 1}
+{"abstract_id": "25340383", "label": "methods", "text": "This was a prospective randomized clinical trial .", "sentence_id": 2}
+{"abstract_id": "25340383", "label": "methods", "text": "Following pulmonary rehabilitation , @,@ patients with severe emphysema were randomly assigned to maximal medical therapy or to lung volume reduction surgery ( LVRS ) .", "sentence_id": 3}
+{"abstract_id": "25340383", "label": "methods", "text": "A generic quality-of-life measure , known as the Quality of Well-being Scale ( QWB ) , was administered at baseline and again at @ , @ , @ , @ , @ , @ , and @ months following treatment assignment .", "sentence_id": 4}
+{"abstract_id": "25340383", "label": "results", "text": "At baseline , QWB scores were comparable for the Medical and LVRS groups .", "sentence_id": 5}
+{"abstract_id": "25340383", "label": "results", "text": "For both groups , scores significantly improved following the rehabilitation program .", "sentence_id": 6}
+{"abstract_id": "25340383", "label": "results", "text": "The QWB scores before death for patients in the LVRS group improved up to the year @ visit , whereas scores for the Medical group dropped significantly following the baseline visit .", "sentence_id": 7}
+{"abstract_id": "25340383", "label": "results", "text": "Imputing zeros ( @ ) for death , QWB scores decreased significantly for both groups .", "sentence_id": 8}
+{"abstract_id": "25340383", "label": "results", "text": "With or without scoring death as @ , the LVRS group achieved better outcomes , and the significant differences were maintained until the sixth year .", "sentence_id": 9}
+{"abstract_id": "25340383", "label": "results", "text": "Over @ years of follow-up , LVRS produced an average of @ quality-adjusted life years ( QALYs ) , or the equivalent of about @ months of well life .", "sentence_id": 10}
+{"abstract_id": "25340383", "label": "conclusions", "text": "Compared with maximal medical therapy alone , patients undergoing maximal medical therapy plus LVRS experienced improved health-related quality of life and gained more QALYs .", "sentence_id": 11}
+{"abstract_id": "24228534", "label": "objective", "text": "To observe the effect of combination of Immune @ and HAART on the CD@ + T cell count and its immune reconstitution rate .", "sentence_id": 0}
+{"abstract_id": "24228534", "label": "methods", "text": "Two hundred and twenty eight HIV/AIDS patients were randomly divided into treatment group and control group , patients from treatment group received Immune @ combined HAART therapy , patients from control group was given placebo combined HAART and evaluate the change of CD@ + T cell count and its immune reconstitution rate .", "sentence_id": 1}
+{"abstract_id": "24228534", "label": "results", "text": "In patients with CD@ + T cells baseline level ( @-@ cell x microL ( -@ ) ) , Immune reconstitution rate of treatment group is significantly higher than the control group .", "sentence_id": 2}
+{"abstract_id": "24228534", "label": "conclusions", "text": "Immune @ combined HAART can effectively promote the immune reconstitution of patients with high CD@ + T cells baseline level ( @-@ cell x microL ( -@ ) ) and show little side effect and is safe to treat HIV/AIDS disease .", "sentence_id": 3}
+{"abstract_id": "24726095", "label": "background", "text": "Concurrent treatment of HIV and tuberculosis is complicated by drug interactions .", "sentence_id": 0}
+{"abstract_id": "24726095", "label": "background", "text": "We explored the safety and efficacy of raltegravir as an alternative to efavirenz for patients co-infected with HIV and tuberculosis .", "sentence_id": 1}
+{"abstract_id": "24726095", "label": "methods", "text": "We did a multicentre , phase @ , non-comparative , open-label , randomised trial at eight sites in Brazil and France .", "sentence_id": 2}
+{"abstract_id": "24726095", "label": "methods", "text": "Using a computer-generated randomisation sequence , we randomly allocated antiretroviral-naive adult patients with HIV-@ and tuberculosis ( aged @ years with a plasma HIV RNA concentration of > @ copies per mL ) to receive raltegravir @ mg twice a day , raltegravir @ mg twice daily , or efavirenz @ mg once daily plus tenofovir and lamivudine ( @:@:@ ; stratified by country ) .", "sentence_id": 3}
+{"abstract_id": "24726095", "label": "methods", "text": "Patients began study treatment after the start of tuberculosis treatment .", "sentence_id": 4}
+{"abstract_id": "24726095", "label": "methods", "text": "The primary endpoint was virological suppression at @ weeks ( HIV RNA < @ copies per mL ) in all patients who received at least one dose of study drug ( modified intention-to-treat analysis ) .", "sentence_id": 5}
+{"abstract_id": "24726095", "label": "methods", "text": "We recorded death , study drug discontinuation , and loss to follow-up as failures to achieve the primary endpoint .", "sentence_id": 6}
+{"abstract_id": "24726095", "label": "methods", "text": "We assessed safety in all patients who received study drugs .", "sentence_id": 7}
+{"abstract_id": "24726095", "label": "methods", "text": "This study is registered in ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24726095", "label": "results", "text": "Between July @ , @ , and June @ , @ , we enrolled and randomly assigned treatment to @ individuals ; @ ( @ in each group ) received at least one dose of the study drug and were included in the primary analysis .", "sentence_id": 9}
+{"abstract_id": "24726095", "label": "results", "text": "@ patients ( @ % ) completed follow-up at week @ .", "sentence_id": 10}
+{"abstract_id": "24726095", "label": "results", "text": "At week @ , virological suppression was achieved in @ patients ( @ % , @ % CI @-@ ) in the raltegravir @ mg group , @ patients ( @ % , @-@ ) in the raltegravir @ mg group , and @ patients ( @ % , @-@ ) in the efavirenz group .", "sentence_id": 11}
+{"abstract_id": "24726095", "label": "results", "text": "The adverse-event profile was much the same across the three groups .", "sentence_id": 12}
+{"abstract_id": "24726095", "label": "results", "text": "Three ( @ % ) patients allocated to efavirenz and three ( @ % ) patients allocated to raltegravir @ mg twice daily discontinued the study drugs due to adverse events .", "sentence_id": 13}
+{"abstract_id": "24726095", "label": "results", "text": "Seven patients died during the study ( one in the raltegravir @ mg group , four in the raltegravir @ mg group , and two in the efavirenz group ) : none of the deaths was deemed related to study treatment .", "sentence_id": 14}
+{"abstract_id": "24726095", "label": "conclusions", "text": "Raltegravir @ mg twice daily might be an alternative to efavirenz for the treatment of patients co-infected with HIV and tuberculosis .", "sentence_id": 15}
+{"abstract_id": "25242045", "label": "background", "text": "Panobinostat is a potent oral pan-deacetylase inhibitor that in preclinical studies has synergistic anti-myeloma activity when combined with bortezomib and dexamethasone .", "sentence_id": 0}
+{"abstract_id": "25242045", "label": "background", "text": "We aimed to compare panobinostat , bortezomib , and dexamethasone with placebo , bortezomib , and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma .", "sentence_id": 1}
+{"abstract_id": "25242045", "label": "methods", "text": "PANORAMA@ is a multicentre , randomised , placebo-controlled , double-blind phase @ trial of patients with relapsed or relapsed and refractory multiple myeloma who have received between one and three previous treatment regimens .", "sentence_id": 2}
+{"abstract_id": "25242045", "label": "methods", "text": "Patients were randomly assigned ( @:@ ) via an interactive web-based and voice response system , stratified by number of previous treatment lines and by previous use of bortezomib , to receive @ day cycles of placebo or panobinostat ( @ mg ; on days @ , @ , @ , @ , @ , @ , orally ) , both in combination with bortezomib ( @ mg/m ( @ ) on days @ , @ , @ , @ , intravenously ) and dexamethasone ( @ mg on days @ , @ , @ , @ , @ , @ , @ , @ , orally ) .", "sentence_id": 3}
+{"abstract_id": "25242045", "label": "methods", "text": "Patients , physicians , and the investigators who did the data analysis were masked to treatment allocation ; crossover was not permitted .", "sentence_id": 4}
+{"abstract_id": "25242045", "label": "methods", "text": "The primary endpoint was progression-free survival ( in accordance with modified European Group for Blood and Marrow Transplantation criteria and based on investigators ' assessment ) and was analysed by intention to treat .", "sentence_id": 5}
+{"abstract_id": "25242045", "label": "methods", "text": "The study is ongoing , but no longer recruiting , and is registered at ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "25242045", "label": "results", "text": "@ patients were enrolled between Jan @ , @ , and Feb @ , @ , with @ randomly assigned to panobinostat , bortezomib , and dexamethasone and @ to placebo , bortezomib , and dexamethasone .", "sentence_id": 7}
+{"abstract_id": "25242045", "label": "results", "text": "Median follow-up was @ months ( IQR @-@ ) in the panobinostat group and @ months ( @-@ ) in the placebo group .", "sentence_id": 8}
+{"abstract_id": "25242045", "label": "results", "text": "Median progression-free survival was significantly longer in the panobinostat group than in the placebo group ( @ months -LSB- @ % CI @-@ -RSB- vs @ months -LSB- @-@ -RSB- ; hazard ratio -LSB- HR -RSB- @ , @ % CI @-@ ; p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25242045", "label": "results", "text": "Overall survival data are not yet mature , although at the time of this analysis , median overall survival was @ months ( @ % CI @-not estimable ) for the panobinostat group and @ months ( @-not estimable ) for the placebo group ( HR @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25242045", "label": "results", "text": "The proportion of patients achieving an overall response did not differ between treatment groups ( @ -LSB- @ % , @ % CI @-@ -RSB- for panobinostat vs @ -LSB- @ % , @-@ -RSB- for placebo ; p = @ ) ; however , the proportion of patients with a complete or near complete response was significantly higher in the panobinostat group than in the placebo group ( @ -LSB- @ % , @ % CI @-@ -RSB- vs @ -LSB- @ % , @-@ -RSB- ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25242045", "label": "results", "text": "Minimal responses were noted in @ ( @ % ) patients in the panobinostat group and in @ ( @ % ) in the placebo group .", "sentence_id": 12}
+{"abstract_id": "25242045", "label": "results", "text": "Median duration of response ( partial response or better ) was @ months ( @ % CI @-@ ) in the panobinostat group and @ months ( @-@ ) in the placebo group , and median time to response ( partial response or better ) was @ months ( @-@ ) in the panobinostat group and @ months ( @-@ ) in the placebo group .", "sentence_id": 13}
+{"abstract_id": "25242045", "label": "results", "text": "Serious adverse events were reported in @ ( @ % ) of @ patients in the panobinostat group and @ ( @ % ) of @ patients in the placebo group .", "sentence_id": 14}
+{"abstract_id": "25242045", "label": "results", "text": "Common grade @-@ laboratory abnormalities and adverse events ( irrespective of association with study drug ) included thrombocytopenia ( @ -LSB- @ % -RSB- in the panobinostat group vs @ -LSB- @ % -RSB- in the placebo group ) , lymphopenia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , diarrhoea ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , asthenia or fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , and peripheral neuropathy ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 15}
+{"abstract_id": "25242045", "label": "conclusions", "text": "Our results suggest that panobinostat could be a useful addition to the treatment armamentarium for patients with relapsed or relapsed and refractory multiple myeloma .", "sentence_id": 16}
+{"abstract_id": "25242045", "label": "conclusions", "text": "Longer follow up will be necessary to determine whether there is any effect on overall survival .", "sentence_id": 17}
+{"abstract_id": "25494594", "label": "background", "text": "Corn peptides ( CPs ) are a novel food prepared from corn gluten meal , which is a main by-product of the corn starch industry .", "sentence_id": 0}
+{"abstract_id": "25494594", "label": "background", "text": "Recently , significant beneficial effects of CPs on early alcoholic liver injury in rats and on acute alcoholic injury in mice were observed .", "sentence_id": 1}
+{"abstract_id": "25494594", "label": "background", "text": "To our knowledge , the present study is the first report showing that CPs supplementation has beneficial effects on lipid profile , oxidative stress and alcoholic liver injury in men with chronic alcohol consumption .", "sentence_id": 2}
+{"abstract_id": "25494594", "label": "methods", "text": "A @-week , randomized , double-blind , placebo-controlled study was conducted between September @ and August @ to assess the hepatoprotective effect of CPs .", "sentence_id": 3}
+{"abstract_id": "25494594", "label": "methods", "text": "A total of @ men were randomized to receive CPs ( n = @ ) , whey protein ( n = @ ) , or corn starch placebo ( n = @ ) at the same dose of @ g twice daily .", "sentence_id": 4}
+{"abstract_id": "25494594", "label": "methods", "text": "@ participants completed the study .", "sentence_id": 5}
+{"abstract_id": "25494594", "label": "methods", "text": "Serum lipid profile , serum markers of liver injury , oxidative stress and inflammation , and fatty liver based on the results of abdominal ultrasonography were assessed at the beginning and end of the intervention .", "sentence_id": 6}
+{"abstract_id": "25494594", "label": "results", "text": "CPs supplementation ( @ g/d ) for @ weeks significantly lowered serum levels or activities of total cholesterol , triglyceride , alanine aminotransferase , aspartate aminotransferase , malondialdehyde and tumor necrosis factor - , and significantly increased serum activities of superoxide dismutase and glutathione peroxidase , but the same dose of whey protein and corn starch ( placebo ) did not demonstrate these effects .", "sentence_id": 7}
+{"abstract_id": "25494594", "label": "conclusions", "text": "Our results indicate that CPs may have protective effects on alcohol-induced liver damage via modulation of lipid metabolism and oxidative stress .", "sentence_id": 8}
+{"abstract_id": "25494594", "label": "conclusions", "text": "CPs may potentially be used as a functional food for the management of alcoholic liver disease in subjects with chronic alcohol consumption .", "sentence_id": 9}
+{"abstract_id": "24772415", "label": "objective", "text": "The aim of this study was to investigate the effect of i.v. infusion of magnesium sulphate during spinal anesthesia on duration of spinal block and postoperative pain .", "sentence_id": 0}
+{"abstract_id": "24772415", "label": "methods", "text": "Forty ASA physical status I and status II , aged between @ and @ , female patients undergoing abdominal hysterectomy under spinal anesthesia were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "24772415", "label": "methods", "text": "Patients in the magnesium group ( Group M , n = @ ) received magnesium sulphate @ mg kg ( -@ ) infusion in @ mL @ % dextrose at @ mL/min rate , and control group ( Group C , n = @ ) received at the same volume of saline during operation in a double-blind randomized manner .", "sentence_id": 2}
+{"abstract_id": "24772415", "label": "methods", "text": "Duration of sensory and motor block , systolic , diastolic , and mean arterial blood pressures , heart rates , pain scores ( VAS values ) , and side effects were recorded for each patient .", "sentence_id": 3}
+{"abstract_id": "24772415", "label": "methods", "text": "Blood and CSF samples were taken for analysis of magnesium concentrations .", "sentence_id": 4}
+{"abstract_id": "24772415", "label": "results", "text": "Regression of sensorial block was longer in Group M when compared with that in Group C ( @ @ versus @ @ min ) ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24772415", "label": "results", "text": "The VAS scores were lower in Group M than those in Group C at the @ time points postoperatively ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24772415", "label": "conclusions", "text": "@ mg kg ( -@ ) of magnesium sulphate i.v. infusion under spinal anesthesia prolongs spinal sensorial block duration and decreases pain VAS scores without complication in patients undergoing abdominal hysterectomy .", "sentence_id": 7}
+{"abstract_id": "24803481", "label": "objective", "text": "To explore effects of a pre-screening life style survey on the subsequent attendance proportion in colorectal cancer screening .", "sentence_id": 0}
+{"abstract_id": "24803481", "label": "methods", "text": "Finnish colorectal cancer screening programme in @ .", "sentence_id": 1}
+{"abstract_id": "24803481", "label": "methods", "text": "Double randomized and controlled follow-up design .", "sentence_id": 2}
+{"abstract_id": "24803481", "label": "methods", "text": "The study population comprised of @,@ individuals born in @ .", "sentence_id": 3}
+{"abstract_id": "24803481", "label": "methods", "text": "In @ to a random sample of every sixth ( n = @,@ ) person we sent a @-paged life style questionnaire , and to another random sample of every sixth person ( n = @,@ ) a @-paged life style and quality of life questionnaire .", "sentence_id": 4}
+{"abstract_id": "24803481", "label": "methods", "text": "One year later , in @ , @,@ individuals of the original cohort were independently randomized ( @:@ ) for colorectal cancer screening ( n = @,@ ) or control group ( n = @,@ ) .", "sentence_id": 5}
+{"abstract_id": "24803481", "label": "methods", "text": "Of those who were invited for screening , @ had received a questionnaire during the previous year .", "sentence_id": 6}
+{"abstract_id": "24803481", "label": "results", "text": "@ individuals ( @ % ) responded to the questionnaire in @ .", "sentence_id": 7}
+{"abstract_id": "24803481", "label": "results", "text": "The overall attendance at screening in @ was @ % in those born in @ ( i.e. the @-year-olds ) .", "sentence_id": 8}
+{"abstract_id": "24803481", "label": "results", "text": "In those who had been sent the survey the attendance in screening was @ % ( @ % for the short and @ % for the long questionnaire ) and in those who had not received the questionnaire it was @ % ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24803481", "label": "conclusions", "text": "We believe that the observed reduction in attendance in those who had been sent a questionnaire earlier is generally true .", "sentence_id": 10}
+{"abstract_id": "24803481", "label": "conclusions", "text": "Thus , if any survey is enclosed in the screening invitation , this finding should be taken into account when planning the programme .", "sentence_id": 11}
+{"abstract_id": "24803481", "label": "conclusions", "text": "Any extra effort requested may reduce the attendance proportion for screening , reducing the population level impact of screening .", "sentence_id": 12}
+{"abstract_id": "24594059", "label": "objective", "text": "Under the directly observed treatment , short course ( DOTS ) program , antituberculosis ( anti-TB ) medications were possibly taken at random time , regardless of whether it was prior to or after meals .", "sentence_id": 0}
+{"abstract_id": "24594059", "label": "objective", "text": "This study was to evaluate the impact of food intake on pharmacokinetic profiles of first-line TB drugs in Taiwanese TB patients , as well as the relationship between drug levels and pharmacogenetics .", "sentence_id": 1}
+{"abstract_id": "24594059", "label": "methods", "text": "This open-label , randomized , cross-over study included newly diagnosed Taiwanese TB patients treated between January @ and February @ at Taipei Medical University-Wan Fang Hospital .", "sentence_id": 2}
+{"abstract_id": "24594059", "label": "methods", "text": "Rifater -LSB- a fixed-dose combination formulation of isoniazid ( INH ) , rifampicin ( RIF ) , and pyrazinamide ( PZA ) -RSB- and ethambutol ( EMB ) were given according to national TB guidelines .", "sentence_id": 3}
+{"abstract_id": "24594059", "label": "methods", "text": "Blood samples were collected prior to and @ hour , @ hours , @ hours , @ hours , and @ hours after dosing under fasting or postprandial conditions .", "sentence_id": 4}
+{"abstract_id": "24594059", "label": "methods", "text": "Pharmacokinetic parameters of the maximum serum concentration ( Cmax ) , time to Cmax , and area under the serum concentration-time curve from the beginning to the @ ( th ) hour ( AUC@-@ ) were calculated .", "sentence_id": 5}
+{"abstract_id": "24594059", "label": "results", "text": "Sixteen TB patients were included and received anti-TB treatment under the DOTS program after discharge .", "sentence_id": 6}
+{"abstract_id": "24594059", "label": "results", "text": "The overall effects showed that food intake reduced the mean Cmax ( INH : @ % , RIF : @ % , EMB @ % , PZA : @ % ) and AUC@-@ ( INH : @ % , RIF : @ % , EMB : @ % , PZA : @ % ) .", "sentence_id": 7}
+{"abstract_id": "24594059", "label": "results", "text": "Meanwhile , food increased the time to Cmax ( INH : @ % , RIF : @ % , EMB : @ % , PZA : @ % ) .", "sentence_id": 8}
+{"abstract_id": "24594059", "label": "conclusions", "text": "Significantly lower serum drug concentrations were observed under postprandial conditions than fasting conditions for INH , RIF , and PZA .", "sentence_id": 9}
+{"abstract_id": "24594059", "label": "conclusions", "text": "The impact of taking random anti-TB drugs under the DOTS program instead of taking drugs regularly prior to meals requires further study .", "sentence_id": 10}
+{"abstract_id": "25117820", "label": "background", "text": "Bevacizumab has broad anti-tumour activity , but substantial risk of hypertension .", "sentence_id": 0}
+{"abstract_id": "25117820", "label": "background", "text": "No reliable markers are available for predicting bevacizumab-induced hypertension .", "sentence_id": 1}
+{"abstract_id": "25117820", "label": "methods", "text": "A genome-wide association study ( GWAS ) was performed in the phase III bevacizumab-based adjuvant breast cancer trial , ECOG-@ , to evaluate for an association between genotypes and hypertension .", "sentence_id": 2}
+{"abstract_id": "25117820", "label": "methods", "text": "GWAS was conducted in those who had experienced systolic blood pressure ( SBP ) > @mmHg during therapy using binary analysis and a cumulative dose model for the total exposure of bevacizumab .", "sentence_id": 3}
+{"abstract_id": "25117820", "label": "methods", "text": "Common toxicity criteria ( CTC ) grade @-@ hypertension was also assessed .", "sentence_id": 4}
+{"abstract_id": "25117820", "label": "methods", "text": "Candidate SNP validation was performed in the randomised phase III trial , ECOG-@ .", "sentence_id": 5}
+{"abstract_id": "25117820", "label": "results", "text": "When using the phenotype of SBP > @mmHg , the most significant association in SV@C ( rs@ ) approached and met genome-wide significance in the binary model ( P = @ @ ( -@ ) ; OR = @ ) and in the cumulative dose model ( P = @ @ ( -@ ) ; HR = @ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "25117820", "label": "results", "text": "Similar associations with rs@ were seen for CTC grade @-@ hypertension but did not meet genome-wide significance .", "sentence_id": 7}
+{"abstract_id": "25117820", "label": "results", "text": "Validation study from ECOG-@ demonstrated a statistically significant association between this SNP and grade @/@ hypertension using the binary model ( P-value = @ ; OR = @ ) .", "sentence_id": 8}
+{"abstract_id": "25117820", "label": "conclusions", "text": "A genetic variant in SV@C predicted clinically relevant bevacizumab-induced hypertension in two independent , randomised phase III trials .", "sentence_id": 9}
+{"abstract_id": "25881753", "label": "objective", "text": "This thorough QT/QTc ( TQT ) study assessed the effects of a supratherapeutic dose of pomaglumetad methionil , a potential treatment for schizophrenia , compared to placebo on the QT interval in subjects with schizophrenia .", "sentence_id": 0}
+{"abstract_id": "25881753", "label": "methods", "text": "This double-blind , @-period crossover study enrolled @ subjects aged @ - @ years , who met Diagnostic and Statistical Manual , Fourth Edition , Test Revision ( DSM-IV-TR ) criteria for schizophrenia ; @ subjects completed the study .", "sentence_id": 1}
+{"abstract_id": "25881753", "label": "methods", "text": "Subjects were randomly assigned to sequences of @ treatment periods of single oral doses of pomaglumetad methionil @ mg , moxifloxacin @ mg , and placebo .", "sentence_id": 2}
+{"abstract_id": "25881753", "label": "methods", "text": "Quadruplicate electrocardiograms ( ECGs ) were extracted from @ hours predose to @ hours postdose and were overread by a blinded central reader .", "sentence_id": 3}
+{"abstract_id": "25881753", "label": "methods", "text": "Time-matched pharmacokinetic ( PK ) parameters were assessed .", "sentence_id": 4}
+{"abstract_id": "25881753", "label": "results", "text": "At all-time points , the upper bound of the @ % @-sided confidence interval ( CI ) for the least squares ( LS ) mean difference in changes from baseline in Fridericia 's corrected QT interval ( QTcF ) between pomaglumetad methionil and placebo was < @ milliseconds ( msec ) .", "sentence_id": 5}
+{"abstract_id": "25881753", "label": "results", "text": "Sufficient assay sensitivity was not achieved , likely due to food effect ; although the maximum observed drug concentration ( Cmax ) with moxifloxacin ( @,@ ng/mL ) was lower than expected , the slope of the regression line of moxifloxacin plasma concentrations versus placebo-subtracted QTcF was similar to that reported in the literature .", "sentence_id": 6}
+{"abstract_id": "25881753", "label": "conclusions", "text": "A single supratherapeutic dose of @ mg pomaglumetad methionil did not prolong QTcF to a clinically significant degree and , importantly , did not result in any absolute QTcF > @ msec or increase in QTcF from predose > @ msec .", "sentence_id": 7}
+{"abstract_id": "25286026", "label": "objective", "text": "The purpose of this study was to evaluate the efficacy of once-daily guanfacine extended release ( GXR ) monotherapy administered either in the morning or evening , using a modified Conners ' Parent Rating Scale-Revised : Short Form ( CPRS-R : S ) assessed three times/day in children with attention-deficit/hyperactivity disorder ( ADHD ) .", "sentence_id": 0}
+{"abstract_id": "25286026", "label": "methods", "text": "This multicenter , double-blind , placebo-controlled study randomized children @-@ years of age with ADHD into three groups : GXR a.m. ( GXR in the morning and placebo in the evening ) , GXR p.m. ( placebo in the morning and GXR in the evening ) , or twice-daily placebo .", "sentence_id": 1}
+{"abstract_id": "25286026", "label": "methods", "text": "The CPRS-R : S , administered in the morning , afternoon , and evening prior to each study visit , was a secondary measure of efficacy .", "sentence_id": 2}
+{"abstract_id": "25286026", "label": "results", "text": "A total of @ subjects were included in the analysis population ( GXR a.m. , n = @ ; GXR p.m. , n = @ ; placebo , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25286026", "label": "results", "text": "At visit @ , last observation carried forward ( LOCF ) , subjects receiving GXR demonstrated significantly greater improvement from baseline in the daily mean CPRS-R : S total score , as well as in each of the morning , afternoon , and evening CPRS-R : S assessments , compared with placebo , regardless of the time of GXR administration ( p < @ vs. placebo for GXR a.m. and GXR p.m. ) .", "sentence_id": 4}
+{"abstract_id": "25286026", "label": "results", "text": "In addition , subjects receiving GXR showed significantly greater improvements from baseline in each subscale score ( oppositional , cognitive problems/inattention , hyperactivity , and ADHD index ) compared with those receiving placebo , regardless of time of administration ( p < @ vs. placebo across all subscales for GXR a.m. and GXR p.m. ) .", "sentence_id": 5}
+{"abstract_id": "25286026", "label": "conclusions", "text": "These results provide further support for the demonstrated efficacy of once-daily GXR in reducing ADHD symptoms , and demonstrate that response is consistent throughout the day regardless of the time of administration , with improvement seen in ratings of oppositional as well as of ADHD symptoms .", "sentence_id": 6}
+{"abstract_id": "24742739", "label": "background", "text": "Disease progression in patients with HER@-positive breast cancer receiving trastuzumab might be associated with activation of the PI@K/Akt/mTOR intracellular signalling pathway .", "sentence_id": 0}
+{"abstract_id": "24742739", "label": "background", "text": "We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab .", "sentence_id": 1}
+{"abstract_id": "24742739", "label": "methods", "text": "In this randomised , double-blind , placebo-controlled , phase @ trial , we recruited women with HER@-positive , trastuzumab-resistant , advanced breast carcinoma who had previously received taxane therapy .", "sentence_id": 2}
+{"abstract_id": "24742739", "label": "methods", "text": "Eligible patients were randomly assigned ( @:@ ) using a central patient screening and randomisation system to daily everolimus ( @ mg/day ) plus weekly trastuzumab ( @ mg/kg ) and vinorelbine ( @ mg/m ( @ ) ) or to placebo plus trastuzumab plus vinorelbine , in @-week cycles , stratified by previous lapatinib use .", "sentence_id": 3}
+{"abstract_id": "24742739", "label": "methods", "text": "The primary endpoint was progression-free survival ( PFS ) by local assessment in the intention-to-treat population .", "sentence_id": 4}
+{"abstract_id": "24742739", "label": "methods", "text": "We report the final analysis for PFS ; overall survival follow-up is still in progress .", "sentence_id": 5}
+{"abstract_id": "24742739", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "24742739", "label": "results", "text": "Between Oct @ , @ , and May @ , @ , @ patients were randomly assigned to everolimus ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "24742739", "label": "results", "text": "Median follow-up at the time of analysis was @ months ( IQR @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24742739", "label": "results", "text": "Median PFS was @ months ( @ % CI @-@ @ ) with everolimus and @ months ( @-@ @ ) with placebo ( hazard ratio @ -LSB- @ % CI @-@ @ -RSB- ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24742739", "label": "results", "text": "The most common grade @-@ adverse events were neutropenia ( @ -LSB- @ % -RSB- of @ patients in the everolimus group vs @ -LSB- @ % -RSB- of @ patients in the placebo group ) , leucopenia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , anaemia ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , febrile neutropenia ( @ -LSB- @ % -RSB- vs ten -LSB- @ % -RSB- ) , stomatitis ( @ -LSB- @ % -RSB- vs four -LSB- @ % -RSB- ) , and fatigue ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 10}
+{"abstract_id": "24742739", "label": "results", "text": "Serious adverse events were reported in @ ( @ % ) patients in the everolimus group and @ ( @ % ) in the placebo group ; two on-treatment deaths due to adverse events occurred in each group .", "sentence_id": 11}
+{"abstract_id": "24742739", "label": "conclusions", "text": "The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated , HER@-positive , advanced breast cancer .", "sentence_id": 12}
+{"abstract_id": "24742739", "label": "conclusions", "text": "The clinical benefit should be considered in the context of the adverse event profile in this population .", "sentence_id": 13}
+{"abstract_id": "24809838", "label": "background", "text": "Opioid consumption after posterior spinal fusion is known to be high and often exceeds those reported in other major surgical procedures .", "sentence_id": 0}
+{"abstract_id": "24809838", "label": "background", "text": "A number of clinical trials provide evidence that the perioperative use of subanesthetic doses of ketamine reduces pain and opioid requirements in some surgical procedures , but the effect of prolonged perioperative low-dose ketamine infusion in patients undergoing posterior spinal fusion for pediatric scoliosis surgery is unknown .", "sentence_id": 1}
+{"abstract_id": "24809838", "label": "objective", "text": "To test the hypothesis that a @-h perioperative low-dose ketamine infusion would decrease opioid use in pediatric patients undergoing posterior spinal fusion .", "sentence_id": 2}
+{"abstract_id": "24809838", "label": "methods", "text": "In a double-blind prospective controlled trial , patients undergoing posterior spinal fusion for scoliosis were randomized to receive perioperative low-dose ketamine or placebo control .", "sentence_id": 3}
+{"abstract_id": "24809838", "label": "methods", "text": "Patients received general anesthesia , intraoperative remifentanil , and morphine patient-controlled analgesia postoperatively .", "sentence_id": 4}
+{"abstract_id": "24809838", "label": "methods", "text": "Daily opioid consumption , self-reported pain scores , and sedation scores were measured .", "sentence_id": 5}
+{"abstract_id": "24809838", "label": "results", "text": "Fifty-four patients were enrolled and @ completed the study .", "sentence_id": 6}
+{"abstract_id": "24809838", "label": "results", "text": "Contrary to our hypothesis , ketamine - and control-treated patients had similar postoperative opioid use , pain scores , and sedation scores measurements .", "sentence_id": 7}
+{"abstract_id": "24809838", "label": "results", "text": "In contrast , ketamine-treated patients required less intraoperative remifentanil compared with control ( mean @ mg vs. @mg , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24809838", "label": "results", "text": "Number of vertebrae instrumented , time between end-of-surgery and @h assessment , or remifentanil doses did not impact on postoperative opioid use .", "sentence_id": 9}
+{"abstract_id": "24809838", "label": "results", "text": "Over @-h postoperatively , morphine-equivalent consumption was lower ( -@ , P = @ ) and sedation score was higher ( @ , P = @ ) in male patients , compared with female patients .", "sentence_id": 10}
+{"abstract_id": "24809838", "label": "conclusions", "text": "These findings do not support the use of perioperative low-dose ketamine to decrease opioid use in children with scoliosis undergoing posterior spinal fusion .", "sentence_id": 11}
+{"abstract_id": "24593664", "label": "background", "text": "Emollient therapy is used frequently to prevent nosocomial infection in the management of preterm infants , despite a lack of adequate evidence of its efficacy .", "sentence_id": 0}
+{"abstract_id": "24593664", "label": "objective", "text": "To assess the efficacy of prophylactic whole-body application of pure preservative-free topical petroleum jelly on the incidence of nosocomial sepsis in very low-birthweight ( VLBW ) infants .", "sentence_id": 1}
+{"abstract_id": "24593664", "label": "methods", "text": "A prospective , randomised controlled trial of the application of topical petroleum jelly was conducted .", "sentence_id": 2}
+{"abstract_id": "24593664", "label": "methods", "text": "Infants weighing < @ g at birth and with a gestational age of @ weeks were included .", "sentence_id": 3}
+{"abstract_id": "24593664", "label": "methods", "text": "The intervention group received twice-daily topical therapy of @ g/kg pure , preservative-free topical petroleum jelly until the completion of @ weeks of gestation .", "sentence_id": 4}
+{"abstract_id": "24593664", "label": "methods", "text": "The control group received no topical petroleum jelly treatment .", "sentence_id": 5}
+{"abstract_id": "24593664", "label": "methods", "text": "The primary outcome was the incidence of late-onset sepsis during hospitalisation .", "sentence_id": 6}
+{"abstract_id": "24593664", "label": "methods", "text": "Other data collected included the pattern of temperature control , weight changes , fluid requirements , serum bilirubin level , electrolyte imbalance and skin condition .", "sentence_id": 7}
+{"abstract_id": "24593664", "label": "results", "text": "Thirty-five infants in the intervention group and @ in the control group were recruited .", "sentence_id": 8}
+{"abstract_id": "24593664", "label": "results", "text": "Birthweight , gestational age , gender and perinatal variables were comparable in the two groups .", "sentence_id": 9}
+{"abstract_id": "24593664", "label": "results", "text": "There was a trend towards an increased incidence of culture-proven nosocomial sepsis in the intervention group - @ episodes ( @ % ) in the intervention group vs @ ( @ % ) in the control group , and an increased rate of NEC - @ % in the intervention group vs @ % in the control group .", "sentence_id": 10}
+{"abstract_id": "24593664", "label": "results", "text": "The intervention group had better skin condition throughout their stay and the incubator ambient temperature was lower in the intervention group in the @st week of life .", "sentence_id": 11}
+{"abstract_id": "24593664", "label": "results", "text": "The fluid balance of the infants in the intervention group was better , as reflected by their mean ( SD ) shorter time to regain birthweight -LSB- @ ( @ ) vs @ ( @ ) days -RSB- , and there were fewer episodes of hypernatraemia in the @st week of life , although none of these reached statistical significance .", "sentence_id": 12}
+{"abstract_id": "24593664", "label": "results", "text": "However , there was a significantly lower mean ( SD ) level of maximum hyperbilirubinaemia -LSB- @ ( @ ) vs @ ( @ ) mmol/L , P = @ ) in the intervention group .", "sentence_id": 13}
+{"abstract_id": "24593664", "label": "conclusions", "text": "Although prophylactic topical application of pure , preservative-free petroleum jelly brought substantial improvement of skin condition and temperature control , it was associated with a trend towards an increased rate of nosocomial sepsis .", "sentence_id": 14}
+{"abstract_id": "25434320", "label": "objective", "text": "To study the efficacy and safety of drotaverine hydrochloride ( HCl ) @ mg tablet given thrice a day in the symptomatic relief of patients with irritable bowel syndrome ( IBS ) .", "sentence_id": 0}
+{"abstract_id": "25434320", "label": "methods", "text": "The study was a multicentric , randomized , double-blind , placebo-controlled parallel group study performed at three centers .", "sentence_id": 1}
+{"abstract_id": "25434320", "label": "methods", "text": "The patients who fulfilled Rome II Criteria of IBS were included in the study .", "sentence_id": 2}
+{"abstract_id": "25434320", "label": "methods", "text": "A total of @ patients with IBS were randomized to drotaverine and placebo treatment groups .", "sentence_id": 3}
+{"abstract_id": "25434320", "label": "methods", "text": "Abdominal pain and stool frequency were measured every week in both the groups for all the @ weeks of treatment duration .", "sentence_id": 4}
+{"abstract_id": "25434320", "label": "methods", "text": "Subject Global Assessment of Relief ( SGA ) of IBS symptoms was assessed at the end of the study .", "sentence_id": 5}
+{"abstract_id": "25434320", "label": "methods", "text": "Appropriate statistical analysis was done using SPSS software .", "sentence_id": 6}
+{"abstract_id": "25434320", "label": "methods", "text": "Mann-Whitney U-test ( two-tailed ) , Wilcoxon signed ranks test , and McNemar tests .", "sentence_id": 7}
+{"abstract_id": "25434320", "label": "results", "text": "Pain frequency decreased significantly ( P < @ ) in @ ( @ % ) , @ ( @ % ) , and @ ( @ % ) patients in the drotaverine group , at the end of @nd , @rd , and @th weeks , respectively , as compared with @ ( @ % ) , @ ( @ % ) , and @ ( @ % ) in the placebo group .", "sentence_id": 8}
+{"abstract_id": "25434320", "label": "results", "text": "Pain severity scores also decreased significantly in the drotaverine group @ ( @ % ) as compared with placebo @ ( @ % ) after @ weeks .", "sentence_id": 9}
+{"abstract_id": "25434320", "label": "results", "text": "Drotaverine HCl was shown to provide significant improvement ( P < @ ) in global relief in abdominal pain as perceived by the patient ( @ % vs @ % ) and the clinician ( @ % vs @ % ) in the drotaverine group as compared with placebo .", "sentence_id": 10}
+{"abstract_id": "25434320", "label": "results", "text": "There is significant ( P < @ ) improvement in stool frequency in drotaverine HCl treatment group as compared with placebo .", "sentence_id": 11}
+{"abstract_id": "25434320", "label": "results", "text": "The drug is well tolerated without any major side effects .", "sentence_id": 12}
+{"abstract_id": "25434320", "label": "conclusions", "text": "A @-week treatment with drotaverine significantly improves abdominal symptoms in patients with IBS .", "sentence_id": 13}
+{"abstract_id": "24385331", "label": "background", "text": "Patients with end-stage renal failure ( ESRF ) need integrated health care to maintain a desirable quality of life .", "sentence_id": 0}
+{"abstract_id": "24385331", "label": "background", "text": "Studies suggest that post-discharge nurseled telephone support has a positive effect for patients suffering from chronic diseases .", "sentence_id": 1}
+{"abstract_id": "24385331", "label": "background", "text": "But the post-discharge care is under-developed in mainland China and the effects of post-discharge care on patients with peritoneal dialysis have not been conclusive .", "sentence_id": 2}
+{"abstract_id": "24385331", "label": "objective", "text": "The purpose of this study is to test the effectiveness of postdischarge nurse-led telephone support on patients with peritoneal dialysis in mainland China .", "sentence_id": 3}
+{"abstract_id": "24385331", "label": "methods", "text": "A randomized controlled trial was conducted in the medical department of a regional hospital in Guangzhou .", "sentence_id": 4}
+{"abstract_id": "24385331", "label": "methods", "text": "@ patients were recruited , @ in the study group and @ in the control group .", "sentence_id": 5}
+{"abstract_id": "24385331", "label": "methods", "text": "The control group received routine hospital discharge care .", "sentence_id": 6}
+{"abstract_id": "24385331", "label": "methods", "text": "The study group received post-discharge nurse-led telephone support .", "sentence_id": 7}
+{"abstract_id": "24385331", "label": "methods", "text": "The quality of life ( Kidney Disease Quality of Life Short Form , KDQOL-SF ) , blood chemistry , complication control , readmission and clinic visit rates were observed at three time intervals : baseline before discharge ( T@ ) , @ ( T@ ) and @ ( T@ ) weeks after discharge .", "sentence_id": 8}
+{"abstract_id": "24385331", "label": "results", "text": "Statistically significant effects were found for symptom/problem , work status , staff encouragement , patient satisfaction and energy/fatigue in KDQOL-SF and @-day ( @-week ) clinic visit rates between the two groups .", "sentence_id": 9}
+{"abstract_id": "24385331", "label": "results", "text": "The study group had more significant improvement than the control group for sleep , staff encouragement at both T@ and T@ , and pain at T@ and patient satisfaction at T@ .", "sentence_id": 10}
+{"abstract_id": "24385331", "label": "results", "text": "No significant differences were observed between the two groups for the baseline measures , other dimensions in KDQOL-SF , blood chemistry , complication control , readmission rates at all time intervals and clinic visit rates at the first two time intervals .", "sentence_id": 11}
+{"abstract_id": "24385331", "label": "conclusions", "text": "Post-discharge nurse-led telephone support for patients undergoing peritoneal dialysis is effective to enhance patients ' well-being in the transition from hospital to home in mainland China .", "sentence_id": 12}
+{"abstract_id": "25637380", "label": "background", "text": "Neoadjuvant treatment provides a unique opportunity to evaluate individual tumor sensitivity .", "sentence_id": 0}
+{"abstract_id": "25637380", "label": "background", "text": "This study evaluated whether a response-guided strategy could improve clinical outcome compared with a standard treatment .", "sentence_id": 1}
+{"abstract_id": "25637380", "label": "methods", "text": "Overall , @ previously untreated stage II-III operable breast cancer patients were randomized to receive either standard treatment ( arm A , n = @ ) , consisting of fluorouracil , epirubicin , and cyclophosphamide ( FEC@ : @ , @ , and @ mg/m ( @ ) , respectively , for @ cycles ) followed by docetaxel ( @ mg/m ( @ ) for @ cycles ) , or adapted treatment ( arm B , n = @ ) , beginning with @ cycles of FEC@ and switching to docetaxel if tumor size decreased by < @ % after @ cycles or < @ % after @ cycles of FEC@ ( ultrasound assessments according to World Health Organization criteria ) .", "sentence_id": 2}
+{"abstract_id": "25637380", "label": "methods", "text": "Otherwise , FEC@ was given for six cycles before surgery .", "sentence_id": 3}
+{"abstract_id": "25637380", "label": "methods", "text": "Intent-to-treat analysis was performed .", "sentence_id": 4}
+{"abstract_id": "25637380", "label": "results", "text": "Similar results were observed for clinical response ( objective response was @ % vs @ % , p = @ ) , breast conservation surgery ( BCS ; @ % vs @ % , p = @ ) , and pathological complete response rate ( Chevallier classification : @ % vs @ % , p = @ ; Statloff classification : @ % vs @ % , p = @ ) between arms A and B. Similar toxicities were observed , even with unbalanced numbers of FEC@ and docetaxel courses .", "sentence_id": 5}
+{"abstract_id": "25637380", "label": "conclusions", "text": "Adapted and standard treatments had similar results in terms of tumor response , BCS rate , and tolerability .", "sentence_id": 6}
+{"abstract_id": "25637380", "label": "conclusions", "text": "Further survival outcome data are expected .", "sentence_id": 7}
+{"abstract_id": "26021224", "label": "objective", "text": "To evaluate the influence of at least three abutment changes against the placement of a definitive abutment , which was no longer removed , on hard and soft tissue changes , and to compare the clinical outcomes of immediate non-occlusal loading versus conventional loading .", "sentence_id": 0}
+{"abstract_id": "26021224", "label": "methods", "text": "Eighty patients requiring one single crown or one fixed partial prosthesis supported by a maximum of three implants were randomised , after implants were placed with more than @ Ncm , according to a parallel group design to receive definitive abutments which were loaded immediately ( definitive abutment or immediate loading group ) or transmucosal abutments which experienced delayed loading after @ months and were removed at least three times : @ ) during the making of the impression ( @ months after implant placement ) ; @ ) when checking the zirconium core of titanium abutments at single crowns or the fitting of the metal structure at prostheses supported by multiple implants ; @ ) at delivery of the definitive prostheses ( repeated disconnection or conventional loading group ) .", "sentence_id": 1}
+{"abstract_id": "26021224", "label": "methods", "text": "Patients were treated in four centres and each patient contributed to the study with only one prosthesis followed for @ months after initial loading .", "sentence_id": 2}
+{"abstract_id": "26021224", "label": "methods", "text": "Outcome measures were : prosthesis/implant failures , any complication , peri-implant marginal bone level changes , and patient satisfaction .", "sentence_id": 3}
+{"abstract_id": "26021224", "label": "results", "text": "Forty patients were randomly allocated to each group according to a parallel group design .", "sentence_id": 4}
+{"abstract_id": "26021224", "label": "results", "text": "No patient dropped-out and no implants failed .", "sentence_id": 5}
+{"abstract_id": "26021224", "label": "results", "text": "However four provisional prostheses and one definitive prosthesis had to be remade because of misfitting ( five single crowns ) in the repeated disconnection group ; and one provisional prosthesis had to be remade because of frequent debondings in the immediate loading group ( difference = @ % ; @ % CI : -@ % , @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26021224", "label": "results", "text": "Five complications ( all debondings of the provisional prostheses ) were reported in two patients of the immediate loading group , in comparison to three biological complications in three patients of the repeated disconnection group ( difference = @ % ; @ % CI : -@ % , @ % ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26021224", "label": "results", "text": "All patients were very satisfied or satisfied with the function and aesthetics of the prostheses , and would undergo the same procedure again .", "sentence_id": 8}
+{"abstract_id": "26021224", "label": "results", "text": "Mean peri-implant marginal bone loss @ months after loading was -@ ( @ ) mm for the definitive abutment group and -@ ( @ ) mm for the repeated abutment changes group ( difference = @ ; @ % CI : -@ , @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26021224", "label": "results", "text": "There were no statistically significant differences for any of the outcome measures between the two procedures up to @ months after initial loading .", "sentence_id": 10}
+{"abstract_id": "26021224", "label": "conclusions", "text": "Preliminary short-term data ( @-month post-loading ) showed that repeated abutment changes do not alter bone levels significantly .", "sentence_id": 11}
+{"abstract_id": "26021224", "label": "conclusions", "text": "Immediate non-occlusal loading of dental implants are a viable alternative to conventional loading .", "sentence_id": 12}
+{"abstract_id": "26021224", "label": "conclusions", "text": "Therefore clinicians can use the procedure they find more convenient for their specific patient .", "sentence_id": 13}
+{"abstract_id": "24843957", "label": "objective", "text": "To observe the efficacy difference of electroacupuncture and auricular acupuncture in the treatment of methamphetamine withdrawal syndrome .", "sentence_id": 0}
+{"abstract_id": "24843957", "label": "methods", "text": "Ninety male patients of methamphetamine addiction were randomized into an electroacupuncture group , an auricular acupuncture group and a control group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "24843957", "label": "methods", "text": "In the electroacupuncture group , Neiguan ( PC @ ) , Shenmen ( HT @ ) , Zusanli ( ST @ ) , Sanyinjiao ( SP @ ) , Jiaji ( EX-B @ ) at T@ and L@ were selected bilaterally .", "sentence_id": 2}
+{"abstract_id": "24843957", "label": "methods", "text": "In the auricular acupuncture group , jiaogan ( AH ( @a ) ) , shenmen ( TF@ ) , fei ( CO@ ) and gan ( CO@ ) were selected unilaterally .", "sentence_id": 3}
+{"abstract_id": "24843957", "label": "methods", "text": "The treatment was given @ times a week , totally @ treatments were required .", "sentence_id": 4}
+{"abstract_id": "24843957", "label": "methods", "text": "In the control group , no any intervention was applied .", "sentence_id": 5}
+{"abstract_id": "24843957", "label": "methods", "text": "Separately , before treatment and after @ , @ , @ and @ weeks treatment , the scores of methamphetamine withdrawal syndrome , Hamilton anxiety scale and Hamilton depression scale were observed in each group .", "sentence_id": 6}
+{"abstract_id": "24843957", "label": "results", "text": "The total score of methamphetamine withdrawal syndrome , anxiety score and depression score were obviously reduced in @ , @ and @ weeks of treatment as compared with those before treatment in the electroacupuncture group and the auricular acupuncture group ( all P < @ ) , and showed a trend of gradual decline as the extension of treatment .", "sentence_id": 7}
+{"abstract_id": "24843957", "label": "results", "text": "In @,@,@,@ weeks of treatment , the total score of withdrawal syndrome , anxiety score and depression score in the electroacupuncture group and auricular acupuncture group were lower significantly than those in the control group ( all P < @ ) , in which , the total score of withdrawal syndrome in the electroacupuncture group was lower significantly than that in the auricular acupuncture group in the @th week of treatment ( @ + / - @ vs @ + / - @ , P < @ ) ; the anxiety scores were lower significantly than those in the auricular acupuncture group in @ and @ weeks of treatment ( @ + / - @ vs @ + / - @ , @ + / - @ vs @ + / - @ , both P < @ ) ; the depression scores were lower significantly than those in the auricular acupuncture group in @ , @ and @ weeks of treatment ( @ + / - @ vs @ + / - @ , @ + / - @ vs @ + / - @ , @ + / - @ vs @ + / - @ , all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24843957", "label": "conclusions", "text": "Electroacupuncture at the body points and auricular acupuncture play the therapeutic role in the treatment of methamphetamine withdrawal syndrome , anxiety and depression .", "sentence_id": 9}
+{"abstract_id": "24843957", "label": "conclusions", "text": "The longer time the treatment is with electroacupuncture at the body points , the more obvious the efficacy will be on the above symptoms .", "sentence_id": 10}
+{"abstract_id": "24355665", "label": "background", "text": "Influenza vaccination coverage for U.S. school-aged children is below the @ % national goal .", "sentence_id": 0}
+{"abstract_id": "24355665", "label": "background", "text": "Primary care practices may not have the capacity to vaccinate all children during influenza vaccination season .", "sentence_id": 1}
+{"abstract_id": "24355665", "label": "background", "text": "No real-world models of school-located seasonal influenza ( SLV-I ) programs have been tested .", "sentence_id": 2}
+{"abstract_id": "24355665", "label": "objective", "text": "Determine the feasibility , sustainability , and impact of an SLV-I program providing influenza vaccination to elementary school children during the school day .", "sentence_id": 3}
+{"abstract_id": "24355665", "label": "methods", "text": "In this pragmatic randomized controlled trial of SLV-I during two vaccination seasons , schools were randomly assigned to SLV-I versus standard of care .", "sentence_id": 4}
+{"abstract_id": "24355665", "label": "methods", "text": "Seasonal influenza vaccine receipt , as recorded in the state immunization information system ( IIS ) , was measured .", "sentence_id": 5}
+{"abstract_id": "24355665", "label": "methods", "text": "Intervention and control schools were located in a single western New York county .", "sentence_id": 6}
+{"abstract_id": "24355665", "label": "methods", "text": "Participation ( intervention or control ) included the sole urban school district and suburban districts ( five in Year @ , four in Year @ ) .", "sentence_id": 7}
+{"abstract_id": "24355665", "label": "methods", "text": "After gathering parental consent and insurance information , live attenuated and inactivated seasonal influenza vaccines were offered in elementary schools during the school day .", "sentence_id": 8}
+{"abstract_id": "24355665", "label": "methods", "text": "Data on receipt of @ seasonal influenza vaccination in Year @ ( @-@ ) and Year @ ( @-@ ) were collected on all student grades K through @ at intervention and control schools from the IIS in the Spring of @ and @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24355665", "label": "methods", "text": "Additionally , coverage achieved through SLV-I was compared to coverage of children vaccinated elsewhere .", "sentence_id": 10}
+{"abstract_id": "24355665", "label": "methods", "text": "Preliminary data analysis for Year @ occurred in Spring @ ; final quantitative analysis for both years was completed in late Fall @ .", "sentence_id": 11}
+{"abstract_id": "24355665", "label": "results", "text": "Results are shown for @-@ and @-@ , respectively : Children enrolled in suburban SLV-I versus control schools had vaccination coverage of @ % vs @ % , and @ % vs @ % ( p < @ both years ) .", "sentence_id": 12}
+{"abstract_id": "24355665", "label": "results", "text": "In urban areas , coverage was @ % vs @ % , and @ % vs @ % ( p < @ both years ) .", "sentence_id": 13}
+{"abstract_id": "24355665", "label": "results", "text": "On multilevel logistic analysis with three nested levels ( student , school , school district ) during both vaccination seasons , children were more likely to be vaccinated in SLV-I versus control schools ; ORs were @ ( @ % CI = @ , @ ; p < @ ) and @ ( @ % CI = @ , @ ; p < @ ) .", "sentence_id": 14}
+{"abstract_id": "24355665", "label": "conclusions", "text": "Delivering influenza vaccine during school is a promising approach to improving pediatric influenza vaccination coverage .", "sentence_id": 15}
+{"abstract_id": "24895382", "label": "objective", "text": "Our aim was to evaluate the feasibility of a hydrotherapy treatment in patients with Parkinson 's disease and the effectiveness of this treatment on balance parameters in comparison to a traditional land-based physical therapy .", "sentence_id": 0}
+{"abstract_id": "24895382", "label": "methods", "text": "A randomized single-blind controlled trial .", "sentence_id": 1}
+{"abstract_id": "24895382", "label": "methods", "text": "Outpatients .", "sentence_id": 2}
+{"abstract_id": "24895382", "label": "methods", "text": "Thirty-four patients with Parkinson 's disease in Hoehn-Yahr stage @-@ .", "sentence_id": 3}
+{"abstract_id": "24895382", "label": "methods", "text": "Group @ hydrotherapy treatment , group @ land-based rehabilitation treatment .", "sentence_id": 4}
+{"abstract_id": "24895382", "label": "methods", "text": "The two groups underwent the same rehabilitation period ( @ minutes of treatment , five days a week for two months ) .", "sentence_id": 5}
+{"abstract_id": "24895382", "label": "methods", "text": "The primary outcome measures were the centre of the pressure sway area recorded with open and closed eyes , using a stabilometric platform .", "sentence_id": 6}
+{"abstract_id": "24895382", "label": "methods", "text": "Secondary outcome measures were Unified Parkinson 's Disease Rating Scale II and III , Timed Up and Go Test , Berg Balance Scale , Activities-specific Balance Confidence Scale , Falls Efficacy Scale , Falls diary and Parkinson 's Disease Questionnaire-@ .", "sentence_id": 7}
+{"abstract_id": "24895382", "label": "results", "text": "Hydrotherapy treatment proved to be feasible and safe .", "sentence_id": 8}
+{"abstract_id": "24895382", "label": "results", "text": "Patients in both groups had a significant improvement in all outcome variables .", "sentence_id": 9}
+{"abstract_id": "24895382", "label": "results", "text": "There was a better improvement in patients who underwent hydrotherapy than in patients treated with land-based therapy in the centre of pressure sway area closed eyes ( mean SD change : @ SD@ @ vs. @ SD@ @ , p = @ ) , Berg Balance Scale ( @ SD@ @ vs. @ SD@ @ , p = @ ) , Activities-specific Balance Confidence Scale ( @ SD@ @ vs. @ SD@ @ , p = @ ) , Falls Efficacy Scale ( -@ SD@ @ vs. -@ SD@ @ , p = @ ) , Parkinson 's Disease Quetionnaire-@ ( -@ SD@ @ vs. -@ SD@ @ , p = @ ) and falls diary ( -@ SD@ @ vs. -@ SD@ @ , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24895382", "label": "conclusions", "text": "Our study suggests that hydrotherapy may constitute a possible treatment for balance dysfunction in Parkinsonian patients with moderate stage of disease .", "sentence_id": 11}
+{"abstract_id": "25946647", "label": "objective", "text": "To compare the demographic characteristics and intra - and postoperative outcomes in elderly adults ( @ ) with those of younger adults undergoing early ( < @ days after onset of complaints ) cholecystectomy .", "sentence_id": 0}
+{"abstract_id": "25946647", "label": "methods", "text": "Retrospective analysis from May @ to August @ .", "sentence_id": 1}
+{"abstract_id": "25946647", "label": "methods", "text": "Randomized , multicenter , clinical trial ( ABCAL Study , NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "25946647", "label": "methods", "text": "Individuals with mild or moderate acute calculous cholecystitis ( ACC ) according to the Tokyo Guidelines ( N = @ ; n = @ aged @-@ , median @ ; n = @ aged @-@ , median @ ) .", "sentence_id": 3}
+{"abstract_id": "25946647", "label": "methods", "text": "Demographic characteristics and pre - , intra - , and postoperative data .", "sentence_id": 4}
+{"abstract_id": "25946647", "label": "results", "text": "The elderly group was more likely to have an American Society of Anesthesiologists score of @ or greater ( @ % vs @ % , P < @ ) , higher serum creatinine ( @ vs @ mol/L , P < @ ) , and more-severe ACC ( moderate ACC ( @ % vs @ % , P = @ ) , gangrenous cholecystitis ( @ % vs @ % , P = @ ) ) on preoperative imaging and confirmed intraoperatively .", "sentence_id": 5}
+{"abstract_id": "25946647", "label": "results", "text": "Ulcerated mucosa ( @ % vs @ % , P = @ ) was significantly more frequent in the elderly group .", "sentence_id": 6}
+{"abstract_id": "25946647", "label": "results", "text": "Operative time , postoperative mortality , and postoperative infectious ( @ % vs @ % , P = @ ) and noninfectious ( @ % vs @ % , P = @ ) complications were similar between the two groups .", "sentence_id": 7}
+{"abstract_id": "25946647", "label": "results", "text": "Median length of stay ( @ vs @ days , P = @ ) and readmission rate ( @ % vs @ % , P = @ ) were not significantly higher in the elderly group .", "sentence_id": 8}
+{"abstract_id": "25946647", "label": "results", "text": "No significant difference was observed for the subgroup of participants aged @ and older .", "sentence_id": 9}
+{"abstract_id": "25946647", "label": "conclusions", "text": "In this randomized trial that included a selected sample of older adults , there was no difference in major outcomes between elderly adults and their younger counterparts after early cholecystectomy .", "sentence_id": 10}
+{"abstract_id": "25946647", "label": "conclusions", "text": "The findings are limited because important geriatric outcomes such as delirium and functional decline were not examined .", "sentence_id": 11}
+{"abstract_id": "24317208", "label": "objective", "text": "The aim of present study was to find a better procedure to prevent synkinesis in facial nerve palsy .", "sentence_id": 0}
+{"abstract_id": "24317208", "label": "methods", "text": "A randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "24317208", "label": "methods", "text": "Clinical rehabilitation faculty and general rehabilitation centers .", "sentence_id": 2}
+{"abstract_id": "24317208", "label": "methods", "text": "Twenty - nine patients with facial nerve palsy were selected via electrodiagnosis tests .", "sentence_id": 3}
+{"abstract_id": "24317208", "label": "methods", "text": "The experimental group ( n = @ ) was treated with biofeedback electromyography , whereas the control group ( n = @ ) received common physiotherapy .", "sentence_id": 4}
+{"abstract_id": "24317208", "label": "methods", "text": "All patients received @-year treatment .", "sentence_id": 5}
+{"abstract_id": "24317208", "label": "methods", "text": "Evaluation of facial grading scale before and after treatment and severity of synkinesia .", "sentence_id": 6}
+{"abstract_id": "24317208", "label": "results", "text": "At the end of treatment , there was a rise in facial grading system in both groups compared with baseline ( p < @ , paired t test ) .", "sentence_id": 7}
+{"abstract_id": "24317208", "label": "results", "text": "There were significant differences in the facial grading system between @ groups at the end of the study , but the experimental group showed better result than the other one .", "sentence_id": 8}
+{"abstract_id": "24317208", "label": "results", "text": "The number of patients with synkinesis and the severity of their synkinesis in the experimental group were lesser than those of the control group .", "sentence_id": 9}
+{"abstract_id": "24317208", "label": "conclusions", "text": "Biofeedback therapy is more efficient than common physiotherapy .", "sentence_id": 10}
+{"abstract_id": "24317208", "label": "conclusions", "text": "By using this approach , controlling and reducing synkinesis is more feasible .", "sentence_id": 11}
+{"abstract_id": "24393516", "label": "objective", "text": "The aim of study was to evaluate setting-specific quality indicators ( QIs ) for shared-housing arrangements ( SHA ) regarding effects of a guided quality development process on resident 's quality of life ( QoL ) .", "sentence_id": 0}
+{"abstract_id": "24393516", "label": "background", "text": "SHA are a specific German kind of small-scale living facilities for care-dependent persons with dementia .", "sentence_id": 1}
+{"abstract_id": "24393516", "label": "background", "text": "SHA are disconnected from residential facilities and served by community care services .", "sentence_id": 2}
+{"abstract_id": "24393516", "label": "methods", "text": "In a longitudinal cluster-randomised design @ residents of @ SHA were surveyed for @ year ; the intervention group took part in a quality development process .", "sentence_id": 3}
+{"abstract_id": "24393516", "label": "methods", "text": "QIs , physical and psychological health outcomes including QoL were surveyed .", "sentence_id": 4}
+{"abstract_id": "24393516", "label": "results", "text": "During the @ year follow-up , analyses show a positive trend regarding QI-outcomes in the intervention group , but no statistically significant differences could be proved regarding QoL .", "sentence_id": 5}
+{"abstract_id": "24393516", "label": "conclusions", "text": "Setting-sensitive QIs are absolutely essential to measure quality of care in multi-professional settings like SHA .", "sentence_id": 6}
+{"abstract_id": "24393516", "label": "conclusions", "text": "Further research as well as longer study intervals is essential .", "sentence_id": 7}
+{"abstract_id": "24795201", "label": "background", "text": "In clinical trials , treatment with a combination of the nucleotide polymerase inhibitor sofosbuvir and the antiviral drug ribavirin was associated with high response rates among patients with hepatitis C virus ( HCV ) genotype @ infection , with lower response rates among patients with HCV genotype @ infection .", "sentence_id": 0}
+{"abstract_id": "24795201", "label": "methods", "text": "We conducted a study involving patients with HCV genotype @ or @ infection , some of whom had undergone previous treatment with an interferon-based regimen .", "sentence_id": 1}
+{"abstract_id": "24795201", "label": "methods", "text": "We randomly assigned @ patients with HCV genotype @ infection and @ with HCV genotype @ infection , in a @:@ ratio , to receive sofosbuvir-ribavirin or placebo for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24795201", "label": "methods", "text": "On the basis of emerging data from phase @ trials indicating that patients with HCV genotype @ infection had higher response rates when they were treated for @ weeks , as compared with @ weeks , the study was unblinded , treatment for all patients with genotype @ infection was extended to @ weeks , the placebo group was terminated , and the goals of the study were redefined to be descriptive and not include hypothesis testing .", "sentence_id": 3}
+{"abstract_id": "24795201", "label": "methods", "text": "The primary end point was a sustained virologic response at @ weeks after the end of therapy .", "sentence_id": 4}
+{"abstract_id": "24795201", "label": "results", "text": "Of the @ patients who were enrolled and treated , @ % had cirrhosis and @ % had received previous interferon-based treatment .", "sentence_id": 5}
+{"abstract_id": "24795201", "label": "results", "text": "The criterion for a sustained virologic response was met in @ of @ patients ( @ % ; @ % confidence interval -LSB- CI -RSB- , @ to @ ) with HCV genotype @ infection who were treated for @ weeks and in @ of @ patients ( @ % ; @ % CI , @ to @ ) with HCV genotype @ infection who were treated for @ weeks .", "sentence_id": 6}
+{"abstract_id": "24795201", "label": "results", "text": "Among patients with HCV genotype @ infection , response rates were @ % and @ % among those without and those with cirrhosis , respectively .", "sentence_id": 7}
+{"abstract_id": "24795201", "label": "results", "text": "The most common adverse events were headache , fatigue , and pruritus .", "sentence_id": 8}
+{"abstract_id": "24795201", "label": "conclusions", "text": "Therapy with sofosbuvir-ribavirin for @ weeks in patients with HCV genotype @ infection and for @ weeks in patients with HCV genotype @ infection resulted in high rates of sustained virologic response .", "sentence_id": 9}
+{"abstract_id": "24795201", "label": "conclusions", "text": "( Funded by Gilead Sciences ; VALENCE ClinicalTrials.gov number , NCT@ . )", "sentence_id": 10}
+{"abstract_id": "25484177", "label": "objective", "text": "Herbal remedies play an important role in treatment of psychiatric disorders .", "sentence_id": 0}
+{"abstract_id": "25484177", "label": "objective", "text": "The aim of this study was to assess the efficacy of crocin , the main active constituent of saffron , as an adjunctive treatment in major depressive disorder ( MDD ) .", "sentence_id": 1}
+{"abstract_id": "25484177", "label": "methods", "text": "This study was a randomized , double-blind , placebo-controlled , pilot clinical trial .", "sentence_id": 2}
+{"abstract_id": "25484177", "label": "methods", "text": "It was carried out during @ weeks in two groups ( placebo and treatment ) on @ MDD patients between @ and @ years old in Ibn-e-Sina psychiatric hospital , Mashhad , Iran , from March @ to December @ .", "sentence_id": 3}
+{"abstract_id": "25484177", "label": "methods", "text": "The crocin group ( n = @ ) was given one selective serotonin reuptake inhibitor ( SSRI ) drug ( fluoxetine @mg/day or sertraline @mg/day or citalopram @mg/day ) plus crocin tablets ( @mg/day ; @mg BID ) and placebo group ( n = @ ) was administered one SSRI ( fluoxetine @mg/day or sertraline @mg/day or citalopram @mg/day ) plus placebo ( two placebo tablets per day ) for @ weeks .", "sentence_id": 4}
+{"abstract_id": "25484177", "label": "methods", "text": "Both groups filled beck depression inventory ( BDI ) , beck anxiety inventory ( BAI ) , general health questionnaire ( GHQ ) , the mood disorder questionnaire ( MDQ ) , side effect evaluation questionnaire , and demographic questionnaire before and after one month intervention .", "sentence_id": 5}
+{"abstract_id": "25484177", "label": "results", "text": "The crocin group showed significantly improved scores on BDI , BAI and GHQ compared to placebo group ( Pvalue < @ ) .", "sentence_id": 6}
+{"abstract_id": "25484177", "label": "results", "text": "The averages of decrease in BDI , BAI and GHQ scores in placebo group were @ , @ and @ respectively , whereas the values in crocin group were @ , @ and @ after @ weeks trial .", "sentence_id": 7}
+{"abstract_id": "25484177", "label": "conclusions", "text": "Poor patient compliance with medications and short trial period , small sample size and self-report assessments were the major limitations of this study .", "sentence_id": 8}
+{"abstract_id": "25484177", "label": "conclusions", "text": "These results demonstrated the effect of crocin in depression and could be administered in treatment of MDD patients .", "sentence_id": 9}
+{"abstract_id": "25339468", "label": "objective", "text": "We aimed to determine the relationship between blood lactate , carboxy-hemoglobin ( COHb ) levels and the severity of clinical findings in patients with CO poisoning .", "sentence_id": 0}
+{"abstract_id": "25339468", "label": "methods", "text": "Patients over @ years old and of both gender who were admitted to Emergency Department with the diagnosis of CO poisoning between @ and @ were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "25339468", "label": "methods", "text": "Detailed physical examination of each patient was performed , patients and their relatives were informed about the study and written consents were noted .", "sentence_id": 2}
+{"abstract_id": "25339468", "label": "methods", "text": "The levels of consciousness , physical examination findings , electrocardiographic findings , Glasgow Coma Scale ( GCS ) scores , laboratory results ( lactate , COHb , CK-MB , Troponin-I levels ) and applied treatments -LSB- normobaric oxygen therapy ( NBOT ) , hyperbaric oxygen therapy ( HBOT ) -RSB- were recorded to standart data entry form for each patient .", "sentence_id": 3}
+{"abstract_id": "25339468", "label": "methods", "text": "SPSS for Windows version @ package program was used for statistical analysis of the data .", "sentence_id": 4}
+{"abstract_id": "25339468", "label": "results", "text": "Total @ patients were included in this study .", "sentence_id": 5}
+{"abstract_id": "25339468", "label": "results", "text": "Thirty five patients ( @ % ) received HBOT and lactate , COHb , CKMB , Troponin-I levels of this group were higher than the other patients .", "sentence_id": 6}
+{"abstract_id": "25339468", "label": "results", "text": "Lactate and COHb levels were statistically significantly higher in patients with GCS < @ than the ones with GCS = @ ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25339468", "label": "results", "text": "The patients whose both Troponin-I and CK-MB levels increased have higher lactate levels ( p = @ ) , but COHb levels of these patients did not change ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25339468", "label": "conclusions", "text": "According to our study , blood lactate and COHb levels were both correlated with the changes of consciousness in CO poisoning .", "sentence_id": 9}
+{"abstract_id": "25339468", "label": "conclusions", "text": "Blood lactate levels together with COHb in defining indications for HBO treatment might be suggested .", "sentence_id": 10}
+{"abstract_id": "24443820", "label": "background", "text": "Internet-based cognitive behavioural therapy ( ICBT ) is a promising approach to the prevention and reduction of depressive symptoms among adolescents .", "sentence_id": 0}
+{"abstract_id": "24443820", "label": "background", "text": "This study aimed to evaluate the feasibility and efficacy of disseminating a self-directed internet-based mental health intervention ( MoodGYM ) in senior high schools .", "sentence_id": 1}
+{"abstract_id": "24443820", "label": "background", "text": "It also sought to investigate possible effects of tailored and weekly e-mail reminders on initial uptake and adherence to the intervention .", "sentence_id": 2}
+{"abstract_id": "24443820", "label": "methods", "text": "A baseline survey was conducted in four senior high schools in two Norwegian municipalities ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24443820", "label": "methods", "text": "@ % ( @/@ ) of the students consented to further participation in the trial and were randomly allocated to one of three MoodGYM intervention groups ( tailored weekly e-mail reminder ( n = @ ) , standardized weekly e-mail reminder ( n = @ ) or no e-mail reminder ( n = @ ) ) or a waitlist control group ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24443820", "label": "methods", "text": "We tested for effects of the intervention on depression and self-esteem using multivariate analysis of variance , effects of tailored e-mail and self-reported current need of help on initial uptake of the intervention using logistic regression and the effect of weekly e-mails on adherence using ordinal regression .", "sentence_id": 5}
+{"abstract_id": "24443820", "label": "results", "text": "There was substantial non-participation from the intervention , with only @ % ( @/@ ) participants logging on to MoodGYM , and few proceeding beyond the first part of the programme .", "sentence_id": 6}
+{"abstract_id": "24443820", "label": "results", "text": "No significant effect on depression or self-esteem was found among the sample as a whole or among participants with elevated depression scores at baseline .", "sentence_id": 7}
+{"abstract_id": "24443820", "label": "results", "text": "Having a higher average grade in senior high school predicted initial uptake of the intervention , but tailored e-mail and self-reported current need of help did not .", "sentence_id": 8}
+{"abstract_id": "24443820", "label": "results", "text": "Weekly e-mail prompts did not predict adherence .", "sentence_id": 9}
+{"abstract_id": "24443820", "label": "results", "text": "The main reasons for non-use reported were lack of time/forgetting about it and doubt about the usefulness of the program .", "sentence_id": 10}
+{"abstract_id": "24443820", "label": "conclusions", "text": "Overall , disseminating a self-directed internet-based intervention to a school population proved difficult despite steps taken to reduce barriers in terms of tailoring feedback and dispatching weekly e-mail reminders .", "sentence_id": 11}
+{"abstract_id": "24443820", "label": "conclusions", "text": "Providing mental health interventions within the school environment is likely to ensure better uptake among senior high school students , but there is a need to effectively communicate that such programmes can be helpful .", "sentence_id": 12}
+{"abstract_id": "24220504", "label": "background", "text": "Osteoarthritis is a relatively common musculoskeletal disorder that increases in prevalence with age .", "sentence_id": 0}
+{"abstract_id": "24220504", "label": "background", "text": "Worldwide , knee osteoarthritis is one of the leading causes of disability , particularly in the elderly .", "sentence_id": 1}
+{"abstract_id": "24220504", "label": "background", "text": "In numerous trials of agents for long-term pain therapy , no well-established and replicable results have been achieved .", "sentence_id": 2}
+{"abstract_id": "24220504", "label": "background", "text": "Complementary and alternative medical approaches have been employed for thousands of years to relieve knee osteoarthritis pain .", "sentence_id": 3}
+{"abstract_id": "24220504", "label": "background", "text": "Among herbal medicines , the golden plaster is the preferred and most commonlyused method in China to reduce pain in patients with knee osteoarthritis , as it causes few adverse effects .", "sentence_id": 4}
+{"abstract_id": "24220504", "label": "background", "text": "The purpose of this study will be to evaluate the efficacy and safety of golden plaster on pain in patients with knee osteoarthritis .", "sentence_id": 5}
+{"abstract_id": "24220504", "label": "methods", "text": "This study will be a multicenter randomized , double-blind , placebo-controlled trial .", "sentence_id": 6}
+{"abstract_id": "24220504", "label": "methods", "text": "A total of @ participants aged @ to @ years with knee osteoarthritis , whose scores on a visual analog scale ( VAS ) are more than @ mm , will be randomly allocated into a treatment group and a control group .", "sentence_id": 7}
+{"abstract_id": "24220504", "label": "methods", "text": "A golden plaster will be administered externally to participants in the treatment group for @ weeks , while the control group will receive a placebo plaster externally for @ weeks .", "sentence_id": 8}
+{"abstract_id": "24220504", "label": "methods", "text": "Follow-up will be at regular intervals during a @-week period with a VAS score for pain , quality of life , and complications .", "sentence_id": 9}
+{"abstract_id": "24220504", "label": "conclusions", "text": "This study will be a methodologically sound randomized controlled trial to assess pain relief after the intervention of golden plaster , compared to a placebo intervention in patients with knee osteoarthritis .", "sentence_id": 10}
+{"abstract_id": "24499951", "label": "objective", "text": "Tenofovir disoproxil fumarate ( TDF ) pre-exposure prophylaxis decreases sexual acquisition of HIV infection .", "sentence_id": 0}
+{"abstract_id": "24499951", "label": "objective", "text": "We sought to evaluate the renal safety of TDF in HIV-uninfected persons .", "sentence_id": 1}
+{"abstract_id": "24499951", "label": "methods", "text": "The Iniciativa Profilaxis Pre-Exposicin ( iPrEx ) study randomly assigned @ HIV-seronegative men and transgender women who have sex with men ( MSM ) to receive oral daily TDF coformulated with emtricitabine ( FTC/TDF ) or placebo .", "sentence_id": 2}
+{"abstract_id": "24499951", "label": "methods", "text": "Serum creatinine and phosphorus during randomized treatment and after discontinuation were measured , and creatinine clearance ( CrCl ) was estimated by the Cockcroft-Gault equation .", "sentence_id": 3}
+{"abstract_id": "24499951", "label": "methods", "text": "Indicators of proximal renal tubulopathy ( fractional excretion of phosphorus and uric acid , urine protein , and glucose ) were measured in a substudy .", "sentence_id": 4}
+{"abstract_id": "24499951", "label": "results", "text": "There was a small but statistically significant decrease in CrCl from baseline in the active arm , compared to placebo , which was first observed at week @ ( mean change : -@ vs. -@ ml/min ; P = @ ) , persisted through the last on-treatment visit ( mean change : +@ vs. +@ ml/min ; P = @ ) , and resolved after stopping pre-exposure prophylaxis ( mean change : -@ vs. @ ml/min ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24499951", "label": "results", "text": "The effect was confirmed when stratifying by drug detection .", "sentence_id": 6}
+{"abstract_id": "24499951", "label": "results", "text": "The effect of FTC/TDF on CrCl did not vary by race , age , or history of hypertension .", "sentence_id": 7}
+{"abstract_id": "24499951", "label": "results", "text": "There was no difference in serum phosphate trends between the treatment arms .", "sentence_id": 8}
+{"abstract_id": "24499951", "label": "results", "text": "In the substudy , two participants receiving placebo had indicators of tubulopathy .", "sentence_id": 9}
+{"abstract_id": "24499951", "label": "conclusions", "text": "In HIV-seronegative MSM , randomization to FTC/TDF was associated with a very mild nonprogressive decrease in CrCl that was reversible and managed with routine serum creatinine monitoring .", "sentence_id": 10}
+{"abstract_id": "25375075", "label": "background", "text": "Statin use is frequently associated with muscle-related symptoms .", "sentence_id": 0}
+{"abstract_id": "25375075", "label": "background", "text": "Coenzyme Q@ supplementation has yielded conflicting results in decreasing statin myopathy .", "sentence_id": 1}
+{"abstract_id": "25375075", "label": "background", "text": "Herein , we tested whether coenzyme Q@ supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms .", "sentence_id": 2}
+{"abstract_id": "25375075", "label": "methods", "text": "Fifty patients treated with statins and reporting muscle pain were recruited .", "sentence_id": 3}
+{"abstract_id": "25375075", "label": "methods", "text": "The Q@ group ( n = @ ) received coenzyme Q@ supplementation over a period of @ days ( @ mg twice daily ) , and the control group ( n = @ ) received placebo .", "sentence_id": 4}
+{"abstract_id": "25375075", "label": "methods", "text": "The Brief Pain Inventory ( BPI ) questionnaire was used and blood testing was performed at inclusion in the study and after @ days of supplementation .", "sentence_id": 5}
+{"abstract_id": "25375075", "label": "results", "text": "The intensity of muscle pain , measured as the Pain Severity Score ( PSS ) , in the Q@ group was reduced from @ to @ ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25375075", "label": "results", "text": "The Pain Interference Score ( PIS ) after Q@ supplementation was reduced from @ to @ ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25375075", "label": "results", "text": "In the placebo group , PSS and PIS did not change .", "sentence_id": 8}
+{"abstract_id": "25375075", "label": "results", "text": "Coenzyme Q@ supplementation decreased statin-related muscle symptoms in @ % of patients .", "sentence_id": 9}
+{"abstract_id": "25375075", "label": "results", "text": "The relative values of PSS and PIS significantly decreased ( -@ % and -@ % , respectively ) in the Q@ group compared to placebo group ( both P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25375075", "label": "results", "text": "From baseline , no differences in liver and muscle enzymes or cholesterol values were found .", "sentence_id": 11}
+{"abstract_id": "25375075", "label": "conclusions", "text": "The present results show that coenzyme Q@ supplementation ( @ mg twice daily ) effectively reduced statin-related mild-to-moderate muscular symptoms , causing lower interference of statin-related muscular symptoms with daily activities .", "sentence_id": 12}
+{"abstract_id": "25223178", "label": "objective", "text": "To observe the clinical effect of Guilu Erxian Glue Cataplasm ( GEGC ) on carcinoma of the large intestine patients with myelosuppression after chemotherapy , and further to confirm its efficiency and safety .", "sentence_id": 0}
+{"abstract_id": "25223178", "label": "methods", "text": "Totally @ patients with carcinoma of the large intestine were randomly assigned to two groups .", "sentence_id": 1}
+{"abstract_id": "25223178", "label": "methods", "text": "Meanwhile , they all accepted FOLFIRI chemotherapy .", "sentence_id": 2}
+{"abstract_id": "25223178", "label": "methods", "text": "Patients in the treatment group were additionally applied at Shenque ( RN@ ) , exchanging once per every other day , for @ successive days .", "sentence_id": 3}
+{"abstract_id": "25223178", "label": "methods", "text": "Patients in the control group took placebos with the same dose and dosage as the treatment group .", "sentence_id": 4}
+{"abstract_id": "25223178", "label": "methods", "text": "The blood cell counts ( WBC , NE , and PLT ) were detected before chemotherapy , at day @ , @ , and @ .", "sentence_id": 5}
+{"abstract_id": "25223178", "label": "methods", "text": "The TCM symptoms integrals , Karnofsky performance score ( KPS ) , liver and kidney functions were observed before chemotherapy , at day @ and day @ .", "sentence_id": 6}
+{"abstract_id": "25223178", "label": "methods", "text": "Adverse skin reactions were observed each day .", "sentence_id": 7}
+{"abstract_id": "25223178", "label": "methods", "text": "And the usage of hematopoietic growth factors was recorded .", "sentence_id": 8}
+{"abstract_id": "25223178", "label": "results", "text": "( @ ) The KPS score at day @ was more stable in the treatment group than in the control group ; the WBC and NE counts in the peripheral blood at day @ were higher in the treatment group than in the control group ; and TCM symptoms integrals at day @ was lower in the treatment group than in the control group , all with statistical difference ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25223178", "label": "results", "text": "( @ ) Compared with the control group , the PLT count was higher in the treatment group than in the control group , the usage of rhG-CSF and antibiotics was less in the treatment group than in the control group , all with no statistical difference ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "25223178", "label": "results", "text": "( @ ) No obvious adverse reactions such as liver injury , renal injury , or skin allergy were observed .", "sentence_id": 11}
+{"abstract_id": "25223178", "label": "conclusions", "text": "Adjuvant treatment of GEGC could improve carcinoma of the large intestine patients with myelosuppression to some extent .", "sentence_id": 12}
+{"abstract_id": "25223178", "label": "conclusions", "text": "No relevant adverse reactions were found .", "sentence_id": 13}
+{"abstract_id": "25272583", "label": "background", "text": "The health system responsiveness , defined as non-medical aspect of treatment relating to the protection of the patients ' legitimate rights , is the intrinsic goal of the WHO strategy for @st century .", "sentence_id": 0}
+{"abstract_id": "25272583", "label": "objective", "text": "To describe the patients ' opinions on treatment they received in hospital , namely : admission to hospital , the role of patient in hospital treatment , course of treatment , medical workforce attitude , hospital environment , contact with family and friends , and the efficacy of hospital treatment in respect to responsiveness to patient 's needs and expectations ( dignity , autonomy , confidentiality , communication , prompt attention , social support , basic amenities and choice of provider ) .", "sentence_id": 1}
+{"abstract_id": "25272583", "label": "methods", "text": "The data were collected in @ from @ former patients of the randomly selected @ hospital in Poland .", "sentence_id": 2}
+{"abstract_id": "25272583", "label": "results", "text": "Dignity : Over @ % of patients experienced kindness , empathy , care and gentleness , and over @ % of them had the sense of security in hospital , met with friendliness during the admission to hospital and never encountered inappropriate comments from medical staff .", "sentence_id": 3}
+{"abstract_id": "25272583", "label": "results", "text": "Autonomy : About @ % of patients accepted the active role of patients in hospital , they perceived they had influence on procedures related to hospitalization and course of treatment , and they felt medical staff responded to their requests and concerns .", "sentence_id": 4}
+{"abstract_id": "25272583", "label": "results", "text": "Over @ % of them had opportunity to communicate their concerns to medical staff and to discuss the course of treatment .", "sentence_id": 5}
+{"abstract_id": "25272583", "label": "results", "text": "On the other hand , the explanation of the reason for the refusal to meet their requests was given to only @ % of the patients interested .", "sentence_id": 6}
+{"abstract_id": "25272583", "label": "results", "text": "Confidentiality : @-@ % of patients declared the respect for privacy and confidentiality during collecting the health information and during medical examinations , and were not examined in presence of other people .", "sentence_id": 7}
+{"abstract_id": "25272583", "label": "results", "text": "Nevertheless , only @ % of patients examined so were asked of their consent .", "sentence_id": 8}
+{"abstract_id": "25272583", "label": "results", "text": "Communication : About @ % of patients declared they trusted their physician , received from him explanation regarding the course of treatment and information about further treatment after discharge from hospital , but physicians devoted the time and attention to only @ % of them .", "sentence_id": 9}
+{"abstract_id": "25272583", "label": "results", "text": "Prompt attention : Over @ % of patients perceived simplicity of the formalities of admission to hospital , and short waiting for treatment and additional tests in hospital ( but only @ % received explanation of reason if they waited long ) .", "sentence_id": 10}
+{"abstract_id": "25272583", "label": "results", "text": "Nevertheless , @ % of them % of them perceived they waited for admission to hospital too long , and over @ % for admission to a ward as long .", "sentence_id": 11}
+{"abstract_id": "25272583", "label": "results", "text": "Social support : The unlimited direct and phone contact with family and friends was declared by @ % of patients .", "sentence_id": 12}
+{"abstract_id": "25272583", "label": "results", "text": "Basic amenities : The high percentage of patients assessed positively the marking in hospital ( @ % ) and cleanliness of linen ( @ % ) , followed by the general indoor appearance room in which patient stayed , lack of noise ( @-@ % ) , hospital meals , furniture ( @-@ % ) , availability of personal hygienic articles ( @-@ % ) , cleanliness of hospital room , toilet , showers and bathtubs , and availability of soap ( @-@ % ) .", "sentence_id": 13}
+{"abstract_id": "25272583", "label": "results", "text": "Choice of provider : Only @ % of patients declared that they had influence on choice of the hospital .", "sentence_id": 14}
+{"abstract_id": "25272583", "label": "conclusions", "text": "Responsiveness of Polish hospital patient needs is similar to that of the OECD countries of the lowest health system responsiveness .", "sentence_id": 15}
+{"abstract_id": "25272583", "label": "conclusions", "text": "Compared to the Central European countries , the responsiveness in Polish hospitals is lower than that of Czech Republic and only slightly higher of those of Slovenia , Slovakia and Hungary .", "sentence_id": 16}
+{"abstract_id": "24405833", "label": "background", "text": "Juvenile idiopathic arthritis ( JIA ) is the most common rheumatic disease in children .", "sentence_id": 0}
+{"abstract_id": "24405833", "label": "background", "text": "Children with JIA are at risk of inflammation of the uvea in the eye ( uveitis ) .", "sentence_id": 1}
+{"abstract_id": "24405833", "label": "background", "text": "Overall , @ % to @ % of paediatric uveitis is associated with JIA .", "sentence_id": 2}
+{"abstract_id": "24405833", "label": "background", "text": "Major risk factors for development of uveitis in JIA are oligoarticular pattern of arthritis , an age at onset of arthritis of less than seven years of age , and antinuclear antibody positivity .", "sentence_id": 3}
+{"abstract_id": "24405833", "label": "background", "text": "In the initial stages of mild to moderate inflammation the uveitis is asymptomatic .", "sentence_id": 4}
+{"abstract_id": "24405833", "label": "background", "text": "This has led to current practice of screening all children with JIA for uveitis .", "sentence_id": 5}
+{"abstract_id": "24405833", "label": "background", "text": "Approximately @ % to @ % of patients with JIA develop uveitis in seven years following onset of arthritis .", "sentence_id": 6}
+{"abstract_id": "24405833", "label": "background", "text": "In @ % to @ % of children with JIA-associated uveitis structural complications are present at diagnosis .", "sentence_id": 7}
+{"abstract_id": "24405833", "label": "background", "text": "Furthermore about @ % to @ % of those with severe uveitis will eventually develop visual impairment secondary to ocular complications such as cataract and glaucoma .", "sentence_id": 8}
+{"abstract_id": "24405833", "label": "background", "text": "Defining the severity of inflammation and structural complications in uveitis patients is now possible following Standardised Uveitis Nomenclature ( SUN ) guidelines , and modified to incorporate the consensus of end point and outcome criteria into the design of randomised trials .", "sentence_id": 9}
+{"abstract_id": "24405833", "label": "background", "text": "Despite current screening and therapeutic options ( pre-biologics ) @ % to @ % of children with JIA-associated uveitis may develop bilateral visual impairment and certified legally blind .", "sentence_id": 10}
+{"abstract_id": "24405833", "label": "background", "text": "To date , there remains no controlled trial evidence of benefits of biologic therapy .", "sentence_id": 11}
+{"abstract_id": "24405833", "label": "methods", "text": "This study will randomise @ patients aged @ to @ years with active JIA-associated uveitis ( despite methotrexate ( MTX ) treatment for at least @ weeks ) .", "sentence_id": 12}
+{"abstract_id": "24405833", "label": "methods", "text": "All participants will be treated for @ months , with follow up of @ years from randomisation ( continuing on MTX throughout ) .", "sentence_id": 13}
+{"abstract_id": "24405833", "label": "methods", "text": "All participants will receive a stable dose of MTX and in addition either adalimumab ( @ mg/@ @ ml for patients < @ kg or @ mg/@ @ ml for patients weighing @ kg or more , subcutaneous ( s/c ) injection every @ weeks based on body weight ) , or placebo ( @ ml as appropriate according to body weight ) s/c injection every @ weeks .", "sentence_id": 14}
+{"abstract_id": "24405833", "label": "conclusions", "text": "This is the first randomised controlled trial that will assess the clinical effectiveness , safety and cost effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis .", "sentence_id": 15}
+{"abstract_id": "24515505", "label": "objective", "text": "To estimate the associations between autism spectrum disorder ( ASD ) diagnoses and service use , caregiver time , and cost outcomes .", "sentence_id": 0}
+{"abstract_id": "24515505", "label": "methods", "text": "We used national data from the Medical Expenditure Panel Survey linked to the National Health Interview Survey and a study-specific survey to estimate the annual utilization and costs for health care , school , ASD-related therapy , family-coordinated services , as well as caregiver time in children aged @ to @ years , with and without parent-reported ASD .", "sentence_id": 1}
+{"abstract_id": "24515505", "label": "methods", "text": "Regression analyses estimated the association between ASD diagnosis and cost , controlling for child gender , age , race/ethnicity , insurance status , household income , country region and urban/rural classification , and non-ASD-related illnesses .", "sentence_id": 2}
+{"abstract_id": "24515505", "label": "results", "text": "Children with parent-reported ASD had higher levels of health care office visits and prescription drug use compared with children without ASD ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24515505", "label": "results", "text": "A greater proportion of children in the ASD group used special educational services ( @ % vs. @ % in the control group , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24515505", "label": "results", "text": "After adjusting for child demographic characteristics and non-ASD-associated illnesses , ASD was associated with $ @ ( @ % confidence interval -LSB- CI -RSB- : $ @ - $ @ ) higher health care costs and $ @,@ ( @ % CI : $ @ - $ @,@ ) higher aggregate non-health care costs , including $ @ ( @ % CI : $ @ - $ @,@ ) higher school costs .", "sentence_id": 5}
+{"abstract_id": "24515505", "label": "results", "text": "In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .", "sentence_id": 6}
+{"abstract_id": "24515505", "label": "conclusions", "text": "The economic burden associated with ASD is substantial and can be measured across multiple sectors of our society .", "sentence_id": 7}
+{"abstract_id": "24515505", "label": "conclusions", "text": "Previous analyses that focused on health care underestimated this economic burden , particularly for school systems .", "sentence_id": 8}
+{"abstract_id": "24444682", "label": "objective", "text": "To compare the two different nutritional supports , enteral nutrition and parenteral nutrition in the aspects of nutritional conditions , immune status , the incidence of perioperative complications and quality of life impacts in pancreatic cancer .", "sentence_id": 0}
+{"abstract_id": "24444682", "label": "methods", "text": "For the pancreatic cancer patients which pancreaticoduodenectomy were performed from January @ to December @ in five high-volume medical centres , prospective , randomized controlled study was carried out .", "sentence_id": 1}
+{"abstract_id": "24444682", "label": "methods", "text": "The enrolled patients were randomly divided into enteral nutritional group ( EN group ) and parenteral nutritional group ( PN group ) .", "sentence_id": 2}
+{"abstract_id": "24444682", "label": "methods", "text": "Related indicators , such as nutritional conditions , immune status , incidence of complications , general status and quality of life were assessed .", "sentence_id": 3}
+{"abstract_id": "24444682", "label": "results", "text": "The @ patients were enrolled , while @ cases which @ patients in EN group and @ patients in PN group were qualified to evaluate .", "sentence_id": 4}
+{"abstract_id": "24444682", "label": "results", "text": "The @ cases were dropped out .", "sentence_id": 5}
+{"abstract_id": "24444682", "label": "results", "text": "For the mean hospital stay ( ( @ @ ) days and ( @ @ ) days respcectively ) , Karnofsky score and the life quality scoring , there are no statistical differences between the two groups .", "sentence_id": 6}
+{"abstract_id": "24444682", "label": "results", "text": "In post-operation day @ and day @ , the prealbumin was ( @ @ ) mg/L and ( @ @ ) mg/L in EN group and it was ( @ @ ) mg/L and ( @ @ ) mg/L in PN group , which are all significantly decreased than preoperational levels ( ( @ @ ) mg/L for enteral group and ( @ @ ) mg/L for parenteral group , t = -@ , -@ , -@ , -@ , all P < @ ) , but there was no statistically significant between the @ groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24444682", "label": "results", "text": "Other general indicators such as the albumin , hemoglobin , total bilirubin , blood urea nitrogen , serum creatinine , serum potassium and serum sodium , revealed no statistical differences in the @ groups ( P > @ ) ; The total lymphocytes , CD ( + ) @CD ( + ) @ and CD ( + ) @CD ( + ) @ lymphocytes in PN group was ( @ @ ) @ ( @ ) / L , ( @ @ ) @ ( @ ) / L , and ( @ @ ) @ ( @ ) / L respectively in post-operation day @ , which they are significantly decreased than in preoperational levels of PN group and the respective counterpart of EN group in post-operation day@ ( t = -@ -@ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24444682", "label": "results", "text": "The @ patients were suffered from different complications in the @ groups , but there was no statistical differences among them ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24444682", "label": "conclusions", "text": "Enteral nutritional support could not decrease the incidence of perioperative complications in pancreatic cancer patient , but it can improve the immunonutrition status in comparison with parenteral nutrition .", "sentence_id": 10}
+{"abstract_id": "25257928", "label": "background", "text": "Clustering of outcomes at centers involved in multicenter trials is a type of center effect .", "sentence_id": 0}
+{"abstract_id": "25257928", "label": "background", "text": "The Consolidated Standards of Reporting Trials Statement recommends that multicenter randomized controlled trials ( RCTs ) should account for center effects in their analysis , however most do not .", "sentence_id": 1}
+{"abstract_id": "25257928", "label": "background", "text": "The Early External Cephalic Version ( EECV ) trials published in @ and @ stratified by center at randomization , but did not account for center in the analyses , and due to the nature of the intervention and number of centers , may have been prone to center effects .", "sentence_id": 2}
+{"abstract_id": "25257928", "label": "background", "text": "Using data from the EECV trials , we undertook an empirical study to compare various statistical approaches to account for center effect while estimating the impact of external cephalic version timing ( early or delayed ) on the outcomes of cesarean section , preterm birth , and non-cephalic presentation at the time of birth .", "sentence_id": 3}
+{"abstract_id": "25257928", "label": "methods", "text": "The data from the EECV pilot trial and the EECV@ trial were merged into one dataset .", "sentence_id": 4}
+{"abstract_id": "25257928", "label": "methods", "text": "Fisher 's exact method was used to test the overall effect of external cephalic version timing unadjusted for center effects .", "sentence_id": 5}
+{"abstract_id": "25257928", "label": "methods", "text": "Seven statistical models that accounted for center effects were applied to the data .", "sentence_id": 6}
+{"abstract_id": "25257928", "label": "methods", "text": "The models included : i ) the Mantel-Haenszel test , ii ) logistic regression with fixed center effect and fixed treatment effect , iii ) center-size weighted and iv ) un-weighted logistic regression with fixed center effect and fixed treatment-by-center interaction , iv ) logistic regression with random center effect and fixed treatment effect , v ) logistic regression with random center effect and random treatment-by-center interaction , and vi ) generalized estimating equations .", "sentence_id": 7}
+{"abstract_id": "25257928", "label": "results", "text": "For each of the three outcomes of interest approaches to account for center effect did not alter the overall findings of the trial .", "sentence_id": 8}
+{"abstract_id": "25257928", "label": "results", "text": "The results were similar for the majority of the methods used to adjust for center , illustrating the robustness of the findings .", "sentence_id": 9}
+{"abstract_id": "25257928", "label": "conclusions", "text": "Despite literature that suggests center effect can change the estimate of effect in multicenter trials , this empirical study does not show a difference in the outcomes of the EECV trials when accounting for center effect .", "sentence_id": 10}
+{"abstract_id": "24526708", "label": "background", "text": "Evidence supports peroneal nerve functional electrical stimulation ( FES ) as an effective alternative to ankle-foot orthoses ( AFO ) for treatment of foot drop poststroke , but few randomized controlled comparisons exist .", "sentence_id": 0}
+{"abstract_id": "24526708", "label": "objective", "text": "To compare changes in gait and quality of life ( QoL ) between FES and an AFO in individuals with foot drop poststroke .", "sentence_id": 1}
+{"abstract_id": "24526708", "label": "methods", "text": "In a multicenter randomized controlled trial ( ClinicalTrials.gov #NCT @ ) with unblinded outcome assessments , @ Medicare-eligible individuals at least @ months poststroke wore FES or an AFO for @ months .", "sentence_id": 2}
+{"abstract_id": "24526708", "label": "methods", "text": "Primary endpoints : @-Meter Walk Test ( @MWT ) , a composite of the Mobility , Activities of Daily Living/Instrumental Activities of Daily Living , and Social Participation subscores on the Stroke Impact Scale ( SIS ) , and device-related serious adverse event rate .", "sentence_id": 3}
+{"abstract_id": "24526708", "label": "methods", "text": "Secondary endpoints : @-Minute Walk Test , GaitRite Functional Ambulation Profile ( FAP ) , Modified Emory Functional Ambulation Profile ( mEFAP ) , Berg Balance Scale ( BBS ) , Timed Up and Go , individual SIS domains , and Stroke-Specific Quality of Life measures .", "sentence_id": 4}
+{"abstract_id": "24526708", "label": "methods", "text": "Multiply imputed intention-to-treat analyses were used with primary endpoints tested for noninferiority and secondary endpoints tested for superiority .", "sentence_id": 5}
+{"abstract_id": "24526708", "label": "results", "text": "A total of @ subjects completed the study .", "sentence_id": 6}
+{"abstract_id": "24526708", "label": "results", "text": "FES proved noninferior to the AFO for all primary endpoints .", "sentence_id": 7}
+{"abstract_id": "24526708", "label": "results", "text": "Both the FES and AFO groups improved significantly on the @MWT .", "sentence_id": 8}
+{"abstract_id": "24526708", "label": "results", "text": "Within the FES group , significant improvements were found for SIS composite score , total mFEAP score , individual Floor and Obstacle course time scores of the mEFAP , FAP , and BBS , but again , no between-group differences were found .", "sentence_id": 9}
+{"abstract_id": "24526708", "label": "conclusions", "text": "Use of FES is equivalent to the AFO .", "sentence_id": 10}
+{"abstract_id": "24526708", "label": "conclusions", "text": "Further studies should examine whether FES enables better performance in tasks involving functional mobility , activities of daily living , and balance .", "sentence_id": 11}
+{"abstract_id": "25033113", "label": "objective", "text": "We evaluated changes in social capital following group-based cognitive processing therapy ( CPT ) for female survivors of sexual violence .", "sentence_id": 0}
+{"abstract_id": "25033113", "label": "methods", "text": "We compared CPT with individual support in a cluster-randomized trial in villages in South Kivu province , Democratic Republic of the Congo .", "sentence_id": 1}
+{"abstract_id": "25033113", "label": "methods", "text": "Local psychosocial assistants delivered the interventions from April through July @ .", "sentence_id": 2}
+{"abstract_id": "25033113", "label": "methods", "text": "We evaluated differences between CPT and individual support conditions for structural social capital ( i.e. , time spent with nonkin social network , group membership and participation , and the size of financial and instrumental support networks ) and emotional support seeking .", "sentence_id": 3}
+{"abstract_id": "25033113", "label": "methods", "text": "We analyzed intervention effects with longitudinal random effects models .", "sentence_id": 4}
+{"abstract_id": "25033113", "label": "results", "text": "We obtained small to medium effect size differences for @ study outcomes .", "sentence_id": 5}
+{"abstract_id": "25033113", "label": "results", "text": "Women in the CPT villages increased group membership and participation at @-month follow-up and emotional support seeking after the intervention compared with women in the individual support villages .", "sentence_id": 6}
+{"abstract_id": "25033113", "label": "conclusions", "text": "Results support the efficacy of group CPT to increase dimensions of social capital among survivors of sexual violence in a low-income conflict-affected context .", "sentence_id": 7}
+{"abstract_id": "25066654", "label": "objective", "text": "Gut microbiota provides beneficial effects under physiological conditions , but is able to contribute to inflammatory diseases in susceptible individuals .", "sentence_id": 0}
+{"abstract_id": "25066654", "label": "objective", "text": "Thus , we designed this study to test whether additional intake of symbiotic gel affects specific modifications of gut microbiota in patients with end-stage renal disease ( ESRD ) .", "sentence_id": 1}
+{"abstract_id": "25066654", "label": "methods", "text": "Eighteen patients with ESRD diagnosis with renal replacement therapy ( hemodialysis ) were included in this study .", "sentence_id": 2}
+{"abstract_id": "25066654", "label": "methods", "text": "They were randomly assigned to @ treatment groups : ( @ ) test group ( nutritional counseling + symbiotic ) and ( @ ) control group ( nutritional counseling + placebo ) .", "sentence_id": 3}
+{"abstract_id": "25066654", "label": "methods", "text": "Clinical history and the evaluation of Gastrointestinal Symptom Rating Scale were performed .", "sentence_id": 4}
+{"abstract_id": "25066654", "label": "methods", "text": "Gut microbiota composition was analyzed by real-time polymerase chain reaction from fecal samples .", "sentence_id": 5}
+{"abstract_id": "25066654", "label": "methods", "text": "All subjects were followed for @months .", "sentence_id": 6}
+{"abstract_id": "25066654", "label": "results", "text": "Bifidobacterial counts were higher in the second samples ( mean : @ log@ cells/g ) than in first samples ( @ log @cells/g ) in the patients of the test group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25066654", "label": "results", "text": "Also , lactobacilli counts had a little decrease in the test group ( @ to @ log @ cells/g ) and the control group ( @ to @ log @ cells/g ) , between the first and the second samples .", "sentence_id": 8}
+{"abstract_id": "25066654", "label": "results", "text": "Gastrointestinal symptoms scores ( scale @-@ ) were reduced in the test group ( start @ -LSB- @-@ -RSB- and end @ -LSB- @-@ -RSB- ) compared with control group ( start @ -LSB- @-@ -RSB- and end @ -LSB- @-@ -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "25066654", "label": "conclusions", "text": "Short-term symbiotic treatment in patients with ESRD can lead to the increase of Bifidobacterium counts , maintaining the intestinal microbial balance .", "sentence_id": 10}
+{"abstract_id": "25073879", "label": "objective", "text": "A longitudinal integration approach evaluated all radiographic scores assessed over @ years , rather than only completer data , from @ studies of adalimumab ( ADA ) for rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "25073879", "label": "methods", "text": "The DE@ ( methotrexate -LSB- MTX -RSB- - inadequate responders , longstanding RA ) and PREMIER ( MTX-naive , early RA ) studies , respectively , had @ - or @-year double-blind periods followed by @ - or @-year open-label extensions ( OLEs ) .", "sentence_id": 1}
+{"abstract_id": "25073879", "label": "methods", "text": "Patients received ADA MTX in both OLEs .", "sentence_id": 2}
+{"abstract_id": "25073879", "label": "methods", "text": "Radiographic progression was assessed using change from baseline in modified total Sharp score ( mTSS ) .", "sentence_id": 3}
+{"abstract_id": "25073879", "label": "methods", "text": "A mixed-effects model was used post hoc to evaluate repeated measurements of different data campaigns and to estimate mTSS through up to @ years of treatment based on original randomization groups ( placebo -LSB- PBO -RSB- + MTX or standard dose ADA + MTX ) .", "sentence_id": 4}
+{"abstract_id": "25073879", "label": "results", "text": "Data from patients with baseline and @ postbaseline radiograph were included ( n = @ for DE@ ; n = @ for PREMIER ) .", "sentence_id": 5}
+{"abstract_id": "25073879", "label": "results", "text": "Integrated and @-year completer mTSS progression curves differed slightly .", "sentence_id": 6}
+{"abstract_id": "25073879", "label": "results", "text": "In DE@ , for patients originally assigned PBO + MTX , accrued mTSS at year @ was @ units ( integrated model ) and @ units ( completers ) .", "sentence_id": 7}
+{"abstract_id": "25073879", "label": "results", "text": "For patients originally assigned ADA + MTX , accrued mTSS was @ units by integrated analysis and @ units in completers .", "sentence_id": 8}
+{"abstract_id": "25073879", "label": "results", "text": "In PREMIER , for patients originally assigned PBO + MTX , accrued mTSS at year @ was @ units ( integrated analysis ) and @ units ( completers ) .", "sentence_id": 9}
+{"abstract_id": "25073879", "label": "results", "text": "For patients originally assigned ADA + MTX , accrued mTSS was @ units ( integrated analysis ) and @ units ( completers ) .", "sentence_id": 10}
+{"abstract_id": "25073879", "label": "results", "text": "A higher radiographic progression rate was observed in patients who received delayed versus immediate ADA + MTX treatment .", "sentence_id": 11}
+{"abstract_id": "25073879", "label": "conclusions", "text": "Longitudinal integrated analysis provided robust estimates of radiographic progression that only slightly differed from completers-only scores and confirmed the effects .", "sentence_id": 12}
+{"abstract_id": "24511017", "label": "objective", "text": "We aimed to investigate the clinical significance of the activation of Yes-Associated Protein @ ( YAP@ ) , a key downstream effector of Hippo tumor-suppressor pathway , in ovarian cancer .", "sentence_id": 0}
+{"abstract_id": "24511017", "label": "methods", "text": "A gene expression signature reflecting activation of YAP@ was developed from gene expression data of @ samples from patients with ovarian cancer .", "sentence_id": 1}
+{"abstract_id": "24511017", "label": "methods", "text": "A refined ovarian cancer YAP@ signature was validated in an independent ovarian cancer cohort ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24511017", "label": "methods", "text": "Associations between the YAP@ signature and prognosis were assessed using Kaplan-Meier plots , the log-rank test , and a Cox proportional hazards model .", "sentence_id": 3}
+{"abstract_id": "24511017", "label": "results", "text": "We identified a @-gene expression signature reflecting YAP@ activation in ovarian cancer .", "sentence_id": 4}
+{"abstract_id": "24511017", "label": "results", "text": "In multivariate analysis , the signature was an independent predictor of overall survival ( hazard ratio = @ ; @ % confidence interval = @ to @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24511017", "label": "results", "text": "In subset analysis , the signature identified patients likely to benefit from taxane-based adjuvant chemotherapy .", "sentence_id": 6}
+{"abstract_id": "24511017", "label": "conclusions", "text": "Activation of YAP@ is significantly associated with prognosis and the YAP@ signature can predict response to taxane-based adjuvant chemotherapy in patients with ovarian cancer .", "sentence_id": 7}
+{"abstract_id": "25646321", "label": "background", "text": "Epidemiology associates whole-grain ( WG ) consumption with several health benefits .", "sentence_id": 0}
+{"abstract_id": "25646321", "label": "background", "text": "Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits .", "sentence_id": 1}
+{"abstract_id": "25646321", "label": "objective", "text": "The objective was to assess circulating concentration , excretion , and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors .", "sentence_id": 2}
+{"abstract_id": "25646321", "label": "methods", "text": "A placebo-controlled , parallel-group randomized trial with @ healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed .", "sentence_id": 3}
+{"abstract_id": "25646321", "label": "methods", "text": "Participants replaced precise portions of refined wheat ( RW ) with a fixed amount of selected WG wheat or RW products for @ wk .", "sentence_id": 4}
+{"abstract_id": "25646321", "label": "methods", "text": "At baseline and every @ wk , blood , urine , feces , and anthropometric and body composition measures were collected .", "sentence_id": 5}
+{"abstract_id": "25646321", "label": "methods", "text": "Profiles of phenolic acids in biological samples , plasma markers of metabolic disease and inflammation , and fecal microbiota composition were assessed .", "sentence_id": 6}
+{"abstract_id": "25646321", "label": "results", "text": "WG consumption for @-@ wk determined a @-fold increase in serum dihydroferulic acid ( DHFA ) and a @-fold increase in fecal ferulic acid ( FA ) compared with RW consumption ( no changes ) .", "sentence_id": 7}
+{"abstract_id": "25646321", "label": "results", "text": "Similarly , urinary FA at @ wk doubled the baseline concentration only in WG subjects .", "sentence_id": 8}
+{"abstract_id": "25646321", "label": "results", "text": "Concomitant reduction in plasma tumor necrosis factor - ( TNF - ) after @ wk and increased interleukin ( IL ) -@ only after @ wk with WG compared with RW ( P = @ ) were observed .", "sentence_id": 9}
+{"abstract_id": "25646321", "label": "results", "text": "No significant change in plasma metabolic disease markers over the study period was observed , but a trend toward lower plasma plasminogen activator inhibitor @ with higher excretion of FA and DHFA in the WG group was found .", "sentence_id": 10}
+{"abstract_id": "25646321", "label": "results", "text": "Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances , whereas after WG consumption , it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium .", "sentence_id": 11}
+{"abstract_id": "25646321", "label": "results", "text": "TNF - reduction correlated with increased Bacteroides and Lactobacillus .", "sentence_id": 12}
+{"abstract_id": "25646321", "label": "results", "text": "No effect of dietary interventions on anthropometric measurements and body composition was found .", "sentence_id": 13}
+{"abstract_id": "25646321", "label": "conclusions", "text": "WG wheat consumption significantly increased excreted FA and circulating DHFA .", "sentence_id": 14}
+{"abstract_id": "25646321", "label": "conclusions", "text": "Bacterial communities influenced fecal FA and were modified by WG wheat consumption .", "sentence_id": 15}
+{"abstract_id": "25646321", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 16}
+{"abstract_id": "25102847", "label": "background", "text": "Diarrhoea and respiratory infections are the two biggest causes of child death globally .", "sentence_id": 0}
+{"abstract_id": "25102847", "label": "background", "text": "Handwashing with soap could substantially reduce diarrhoea and respiratory infections , but prevalence of adequate handwashing is low .", "sentence_id": 1}
+{"abstract_id": "25102847", "label": "background", "text": "We tested whether a scalable village-level intervention based on emotional drivers of behaviour , rather than knowledge , could improve handwashing behaviour in rural India .", "sentence_id": 2}
+{"abstract_id": "25102847", "label": "methods", "text": "The study was done in Chittoor district in southern Andhra Pradesh , India , between May @ , @ , and Sept @ , @ .", "sentence_id": 3}
+{"abstract_id": "25102847", "label": "methods", "text": "Eligible villages had a population of @-@ people , a state-run primary school for children aged @-@ years , and a preschool for children younger than @ years .", "sentence_id": 4}
+{"abstract_id": "25102847", "label": "methods", "text": "@ villages ( clusters ) were selected , stratified by population size ( < @ vs > @ ) , and randomly assigned in a @:@ ratio to intervention or control ( no intervention ) .", "sentence_id": 5}
+{"abstract_id": "25102847", "label": "methods", "text": "Clusters were enrolled by the study manager .", "sentence_id": 6}
+{"abstract_id": "25102847", "label": "methods", "text": "Random allocation was done by the study statistician using a random number generator .", "sentence_id": 7}
+{"abstract_id": "25102847", "label": "methods", "text": "The intervention included community and school-based events incorporating an animated film , skits , and public pledging ceremonies .", "sentence_id": 8}
+{"abstract_id": "25102847", "label": "methods", "text": "Outcomes were measured by direct observation in @-@ households per village at baseline and at three follow-up visits ( @ weeks , @ months , and @ months after the intervention ) .", "sentence_id": 9}
+{"abstract_id": "25102847", "label": "methods", "text": "Observers had no connection with the intervention and observers and participant households were told that the study was about domestic water use to reduce the risk of bias .", "sentence_id": 10}
+{"abstract_id": "25102847", "label": "methods", "text": "No other masking was possible .", "sentence_id": 11}
+{"abstract_id": "25102847", "label": "methods", "text": "The primary outcome was the proportion of handwashing with soap at key events ( after defecation , after cleaning a child 's bottom , before food preparation , and before eating ) at all follow-up visits .", "sentence_id": 12}
+{"abstract_id": "25102847", "label": "methods", "text": "The control villages received a shortened version of the intervention before the final follow-up round .", "sentence_id": 13}
+{"abstract_id": "25102847", "label": "methods", "text": "Outcome data are presented as village-level means .", "sentence_id": 14}
+{"abstract_id": "25102847", "label": "results", "text": "Handwashing with soap at key events was rare at baseline in both the intervention and control groups ( @ % -LSB- SD @ -RSB- vs @ % -LSB- @ -RSB- ) .", "sentence_id": 15}
+{"abstract_id": "25102847", "label": "results", "text": "At @ weeks ' follow-up , handwashing with soap at key events was more common in the intervention group than in the control group ( @ % -LSB- SD @ -RSB- vs @ % -LSB- @ -RSB- ; difference @ % , p = @ ) .", "sentence_id": 16}
+{"abstract_id": "25102847", "label": "results", "text": "At the @-month follow-up visit , the proportion handwashing with soap was @ % ( SD @ ) in the intervention group versus @ % ( @ ) in the control group ( difference @ % ; p = @ ) .", "sentence_id": 17}
+{"abstract_id": "25102847", "label": "results", "text": "At the @-month follow-up visit , after the control villages had received the shortened intervention , the proportion handwashing with soap was @ % ( SD @ ) in the intervention group and @ % ( @ ) in the control group .", "sentence_id": 18}
+{"abstract_id": "25102847", "label": "conclusions", "text": "This study shows that substantial increases in handwashing with soap can be achieved using a scalable intervention based on emotional drivers .", "sentence_id": 19}
+{"abstract_id": "24480956", "label": "methods", "text": "A prospective , randomized , and double-blind study .", "sentence_id": 0}
+{"abstract_id": "24480956", "label": "objective", "text": "To compare the efficacy of ramosetron and palonosetron on preventing postoperative nausea and vomiting ( PONV ) associated with opioid-based intravenous patient-controlled analgesia ( IV-PCAopioid ) after lumbar spinal surgery .", "sentence_id": 1}
+{"abstract_id": "24480956", "label": "background", "text": "IV-PCAopioid , an effective method to control pain after lumbar spinal surgery , accompanies PONV .", "sentence_id": 2}
+{"abstract_id": "24480956", "label": "background", "text": "Ramosetron and palonosetron are novel @-hydroxytryptamine @ antagonists known to have longer action duration and higher receptor affinity than their congeners , whereas their relative efficacy has not been validated yet .", "sentence_id": 3}
+{"abstract_id": "24480956", "label": "methods", "text": "One hundred ninety-six patients were randomly and evenly allocated to receive either @ mg of ramosetron or @ mg of palonosetron @ minutes before the end of operation .", "sentence_id": 4}
+{"abstract_id": "24480956", "label": "methods", "text": "Ramosetron or palonosetron were also added to the IV-PCAopioid , which was continuously infused for @ hours postoperatively .", "sentence_id": 5}
+{"abstract_id": "24480956", "label": "methods", "text": "The incidence and intensity of PONV were serially assessed for @ hours postoperatively .", "sentence_id": 6}
+{"abstract_id": "24480956", "label": "methods", "text": "Intensity of pain , volume of IV-PCAopioid consumption , use of rescue analgesics and antiemetics , and adverse events were also assessed .", "sentence_id": 7}
+{"abstract_id": "24480956", "label": "results", "text": "The overall incidence of PONV was lower in the ramosetron group than the palonosetron group ( @ % vs. @ % , P = @ ) without any intergroup difference in the incidence of vomiting .", "sentence_id": 8}
+{"abstract_id": "24480956", "label": "results", "text": "Nausea intensity scores were also lower until @ ( P = @ ) and @ hour ( P = @ ) postoperatively in the ramosetron group than the palonosetron group .", "sentence_id": 9}
+{"abstract_id": "24480956", "label": "results", "text": "Pain intensity scores were significantly lower in the ramosetron group than the palonosetron group for @ hours postoperatively .", "sentence_id": 10}
+{"abstract_id": "24480956", "label": "conclusions", "text": "Ramosetron was superior to palonosetron in term of reducing the incidence and severity of nausea associated with IV-PCAopioid after lumbar spinal surgery .", "sentence_id": 11}
+{"abstract_id": "24480956", "label": "conclusions", "text": "This favorable influence of ramosetron on PONV was translated to significant postoperative pain reduction compared with palonosetron .", "sentence_id": 12}
+{"abstract_id": "25798575", "label": "objective", "text": "For patients with limited prognosis , some medication risks may outweigh the benefits , particularly when benefits take years to accrue ; statins are one example .", "sentence_id": 0}
+{"abstract_id": "25798575", "label": "objective", "text": "Data are lacking regarding the risks and benefits of discontinuing statin therapy for patients with limited life expectancy .", "sentence_id": 1}
+{"abstract_id": "25798575", "label": "objective", "text": "To evaluate the safety , clinical , and cost impact of discontinuing statin medications for patients in the palliative care setting .", "sentence_id": 2}
+{"abstract_id": "25798575", "label": "methods", "text": "This was a multicenter , parallel-group , unblinded , pragmatic clinical trial .", "sentence_id": 3}
+{"abstract_id": "25798575", "label": "methods", "text": "Eligibility included adults with an estimated life expectancy of between @ month and @ year , statin therapy for @ months or more for primary or secondary prevention of cardiovascular disease , recent deterioration in functional status , and no recent active cardiovascular disease .", "sentence_id": 4}
+{"abstract_id": "25798575", "label": "methods", "text": "Participants were randomized to either discontinue or continue statin therapy and were monitored monthly for up to @ year .", "sentence_id": 5}
+{"abstract_id": "25798575", "label": "methods", "text": "The study was conducted from June @ , @ , to May @ , @ .", "sentence_id": 6}
+{"abstract_id": "25798575", "label": "methods", "text": "All analyses were performed using an intent-to-treat approach .", "sentence_id": 7}
+{"abstract_id": "25798575", "label": "methods", "text": "Statin therapy was withdrawn from eligible patients who were randomized to the discontinuation group .", "sentence_id": 8}
+{"abstract_id": "25798575", "label": "methods", "text": "Patients in the continuation group continued to receive statins .", "sentence_id": 9}
+{"abstract_id": "25798575", "label": "methods", "text": "Outcomes included death within @ days ( primary outcome ) , survival , cardiovascular events , performance status , quality of life ( QOL ) , symptoms , number of nonstatin medications , and cost savings .", "sentence_id": 10}
+{"abstract_id": "25798575", "label": "results", "text": "A total of @ patients were enrolled ; @ of these were randomized to discontinue statins , and @ were randomized to continue therapy .", "sentence_id": 11}
+{"abstract_id": "25798575", "label": "results", "text": "Mean ( SD ) age was @ ( @ ) years , @ % of the participants were cognitively impaired , and @ % had cancer .", "sentence_id": 12}
+{"abstract_id": "25798575", "label": "results", "text": "The proportion of participants in the discontinuation vs continuation groups who died within @ days was not significantly different ( @ % vs @ % ; @ % CI , -@ % to @ % ; P = @ ) and did not meet the noninferiority end point .", "sentence_id": 13}
+{"abstract_id": "25798575", "label": "results", "text": "Total QOL was better for the group discontinuing statin therapy ( mean McGill QOL score , @ vs @ ; P = @ ) .", "sentence_id": 14}
+{"abstract_id": "25798575", "label": "results", "text": "Few participants experienced cardiovascular events ( @ in the discontinuation group vs @ in the continuation group ) .", "sentence_id": 15}
+{"abstract_id": "25798575", "label": "results", "text": "Mean cost savings were $ @ per day and $ @ per patient .", "sentence_id": 16}
+{"abstract_id": "25798575", "label": "conclusions", "text": "This pragmatic trial suggests that stopping statin medication therapy is safe and may be associated with benefits including improved QOL , use of fewer nonstatin medications , and a corresponding reduction in medication costs .", "sentence_id": 17}
+{"abstract_id": "25798575", "label": "conclusions", "text": "Thoughtful patient-provider discussions regarding the uncertain benefit and potential decrement in QOL associated with statin continuation in this setting are warranted .", "sentence_id": 18}
+{"abstract_id": "24418164", "label": "background", "text": "Several studies have shown that unnecessary right ventricular pacing has detrimental effects .", "sentence_id": 0}
+{"abstract_id": "24418164", "label": "objective", "text": "To evaluate whether minimization of ventricular pacing as compared with standard dual-chamber pacing ( DDD ) improves clinical outcomes in patients referred for pacemaker or implantable cardioverter-defibrillator ( ICD ) replacement .", "sentence_id": 1}
+{"abstract_id": "24418164", "label": "methods", "text": "In an international single-blind , multicenter , randomized controlled trial , we compared DDD with managed ventricular pacing ( MVP ) , a pacing mode developed to minimize ventricular pacing by promoting intrinsic atrioventricular conduction .", "sentence_id": 2}
+{"abstract_id": "24418164", "label": "methods", "text": "We included patients referred for device replacement with > @ % ventricular pacing , no cardiac resynchronization therapy upgrade indication , no permanent atrial fibrillation ( AF ) , and no permanent complete atrioventricular block .", "sentence_id": 3}
+{"abstract_id": "24418164", "label": "methods", "text": "Follow-up was for @ years .", "sentence_id": 4}
+{"abstract_id": "24418164", "label": "methods", "text": "The primary end point was cardiovascular hospitalization .", "sentence_id": 5}
+{"abstract_id": "24418164", "label": "methods", "text": "The intention-to-treat analysis was performed by using Kaplan-Meier method and the log-rank test .", "sentence_id": 6}
+{"abstract_id": "24418164", "label": "results", "text": "We randomized @ patients ( @ referred for pacemaker and @ referred for ICD replacement ; mean age @ @ years ; @ -LSB- @ % -RSB- men , at @ @ years from first device implantation ) to MVP ( n = @ ) or DDD ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "24418164", "label": "results", "text": "We found no significant differences in the primary end point cardiovascular hospitalization ( MVP : @ % vs DDD : @ % ; P = @ ) and the secondary end point persistent AF ( MVP : @ % vs DDD : @ % ; P = @ ) , permanent AF ( MVP : @ % vs DDD : @ % ; P = @ ) , and composite of death and cardiovascular hospitalization ( MVP : @ % vs DDD : @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24418164", "label": "results", "text": "MVP reduced right ventricular pacing ( median @ % vs @ % ; Wilcoxon , P < @ ) as compared with DDD .", "sentence_id": 9}
+{"abstract_id": "24418164", "label": "conclusions", "text": "In patients referred for pacemaker and ICD replacement with clinically well-tolerated long-term exposure to > @ % ventricular pacing in the ventricle , a strategy to minimize ventricular pacing is not superior to standard DDD in reducing incidence of cardiovascular hospitalizations .", "sentence_id": 10}
+{"abstract_id": "25006633", "label": "objective", "text": "To compare gadobenate dimeglumine-enhanced magnetic resonance imaging ( MRI ) with gadopentetate dimeglumine-enhanced MRI , mammography , and ultrasound for breast cancer detection across different malignant lesion types and across different densities of breast tissue .", "sentence_id": 0}
+{"abstract_id": "25006633", "label": "methods", "text": "In all , @ women with Breast Imaging Reporting and Data System ( BI-RADS ) @ findings on mammography and/or ultrasound underwent identical breast MRI exams at @ T with gadobenate dimeglumine and gadopentetate dimeglumine .", "sentence_id": 1}
+{"abstract_id": "25006633", "label": "methods", "text": "Images were evaluated by three independent blinded radiologists .", "sentence_id": 2}
+{"abstract_id": "25006633", "label": "methods", "text": "Mammography , ultrasound , and combined mammography and/or ultrasound findings were available for @ , @ , and @ women .", "sentence_id": 3}
+{"abstract_id": "25006633", "label": "methods", "text": "Imaging findings were matched with histology data by a fourth , independent , blinded radiologist .", "sentence_id": 4}
+{"abstract_id": "25006633", "label": "methods", "text": "Malignant lesion detection rates and diagnostic performance were compared .", "sentence_id": 5}
+{"abstract_id": "25006633", "label": "results", "text": "In all , @ , @ , and @ confirmed malignant lesions were present in patients undergoing MRI + mammography , MRI + ultrasound , and MRI + mammography and/or ultrasound , respectively .", "sentence_id": 6}
+{"abstract_id": "25006633", "label": "results", "text": "Significantly greater cancer detection rates were noted by all three readers for comparisons of gadobenate dimeglumine-enhanced MRI with mammography ( @ % ; P < @ ) , ultrasound ( @ % ; P < @ ) , and mammography and/or ultrasound ( @ % ; P @ ) but not for comparisons of gadopentetate dimeglumine-enhanced MRI with conventional techniques ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25006633", "label": "results", "text": "The false-positive detection rates were lower on gadobenate dimeglumine-enhanced MRI than on conventional imaging ( @ % vs. @ % at mammography ; @ % vs. @ % at ultrasound ) .", "sentence_id": 8}
+{"abstract_id": "25006633", "label": "results", "text": "Significantly improved cancer detection on MRI was noted in heterogeneously dense breast ( @ % on gadobenate dimeglumine-enhanced MRI vs. @ % on gadopentetate dimeglumine-enhanced MRI vs. @-@ @ % with conventional techniques ) and for invasive cancers ( @ % for invasive ductal carcinoma -LSB- IDC -RSB- on gadobenate dimeglumine-enhanced MRI vs. @ % on gadopentetate dimeglumine-enhanced MRI vs. @ % with conventional techniques ) .", "sentence_id": 9}
+{"abstract_id": "25006633", "label": "results", "text": "Overall diagnostic performance for the detection of cancer was superior on gadobenate dimeglumine-enhanced MRI than on conventional imaging or gadopentetate dimeglumine-enhanced MRI .", "sentence_id": 10}
+{"abstract_id": "25006633", "label": "conclusions", "text": "Gadobenate dimeglumine-enhanced MRI significantly improves cancer detection compared to gadopentetate dimeglumine-enhanced MRI , mammography , and ultrasound in a selected group of patients undergoing breast MRI for preoperative staging or because of inconclusive findings at conventional imaging .", "sentence_id": 11}
+{"abstract_id": "24961091", "label": "objective", "text": "To observe the efficacy of combined use of brimonidine and betaxolol in treatment of primary open angle glaucoma ( POAG ) and ocular hypertension .", "sentence_id": 0}
+{"abstract_id": "24961091", "label": "methods", "text": "A total of @ patients ( @ eyes ) with POAG and ocular hypertension were randomly divided into three groups ( receiving betaxolol , brimonidine and combined administration of betaxolol and brimonidine respectively ) .", "sentence_id": 1}
+{"abstract_id": "24961091", "label": "methods", "text": "The administration was given twice daily in all groups ( @ % betaxolol , @ % brimonidine and @ % betaxolol combined with @ % brimonidine ) .", "sentence_id": 2}
+{"abstract_id": "24961091", "label": "methods", "text": "The changes in intraocular pressure ( IOP ) were observed before , and @ , @ , @ , and @ weeks after treatment .", "sentence_id": 3}
+{"abstract_id": "24961091", "label": "methods", "text": "In addition , the adverse reactions were also recorded post-treatment .", "sentence_id": 4}
+{"abstract_id": "24961091", "label": "results", "text": "The mean IOPs at all the time points after treatment were significantly reduced compared with pre-treatment levels ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24961091", "label": "results", "text": "Patients receiving brimonidine had a greater reduction in IOP compared with their counterparts in the betaxolol group but the difference was not statistically significant .", "sentence_id": 6}
+{"abstract_id": "24961091", "label": "results", "text": "The IOP decline was significantly higher in the combined therapy group than in the other two groups ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24961091", "label": "results", "text": "Few cases presented with slight discomfort , such as sensation of foreign bodies , ocular irritation , dizziness , headache , fatigue , and dryness of mouth and nose .", "sentence_id": 8}
+{"abstract_id": "24961091", "label": "results", "text": "No severe adverse reactions were noted following administration .", "sentence_id": 9}
+{"abstract_id": "24961091", "label": "conclusions", "text": "Combined use of brimonidine and betaxolol is an efficacious treatment of reducing IOP without severe side effects .", "sentence_id": 10}
+{"abstract_id": "25160493", "label": "objective", "text": "Calcium aluminosilicate clay ( CASAD ) is a naturally occurring clay that serves as a cation exchange absorbent .", "sentence_id": 0}
+{"abstract_id": "25160493", "label": "objective", "text": "We hypothesized that oral administration of CASAD would reduce the rate of grade @/@ diarrhea associated with irinotecan use for metastatic colorectal cancer ( CRC ) by adsorbing the SN-@ metabolite .", "sentence_id": 1}
+{"abstract_id": "25160493", "label": "methods", "text": "Patients receiving irinotecan-based chemotherapy were randomized equally between CASAD and placebo arms in this multicenter trial in order to assess differences in the proportions of patients with grade @/@ diarrhea within @ weeks .", "sentence_id": 2}
+{"abstract_id": "25160493", "label": "methods", "text": "Additionally , we compared symptom severity between the two arms using the M.D. Anderson Symptom Inventory .", "sentence_id": 3}
+{"abstract_id": "25160493", "label": "results", "text": "Between May @ and May @ , @ patients were enrolled .", "sentence_id": 4}
+{"abstract_id": "25160493", "label": "results", "text": "In evaluable patients , @ of @ ( @ % ) on the CASAD arm compared to @ of @ ( @ % ) on the placebo arm experienced grade @/@ diarrhea ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25160493", "label": "results", "text": "The rate of any diarrhea among all patients was similar ( CASAD arm , @ % vs. placebo arm , @ % ) .", "sentence_id": 6}
+{"abstract_id": "25160493", "label": "results", "text": "The rate of study dropout was @ % in the CASAD arm and @ % in the placebo arm ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25160493", "label": "results", "text": "No differences were found in symptom severity , individual symptom items , and in serious adverse events between the two arms .", "sentence_id": 8}
+{"abstract_id": "25160493", "label": "conclusions", "text": "Compared to placebo , CASAD use was safe but ineffective in preventing diarrhea in metastatic CRC patients treated with irinotecan-containing chemotherapy regimens .", "sentence_id": 9}
+{"abstract_id": "25160493", "label": "conclusions", "text": "There were no distinct signals in terms of patient symptoms between arms , but there was significantly more patient dropout in the placebo arm .", "sentence_id": 10}
+{"abstract_id": "25160493", "label": "conclusions", "text": "Future CASAD trials will focus on the active treatment of diarrhea .", "sentence_id": 11}
+{"abstract_id": "24937643", "label": "background", "text": "Pulmonary hypertension ( PH ) associated with fibrotic idiopathic interstitial pneumonia ( IIP ; idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia ) confers important additional morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "24937643", "label": "objective", "text": "To evaluate the safety and clinical efficacy of the dual endothelin-@ receptor antagonist bosentan in this patient group .", "sentence_id": 1}
+{"abstract_id": "24937643", "label": "methods", "text": "In a randomized , double-blind , placebo-controlled study , @ patients with fibrotic IIP and right heart catheter confirmed PH were randomized @:@ to bosentan ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24937643", "label": "methods", "text": "The primary study endpoint was a fall from baseline pulmonary vascular resistance index ( PVRi ) of @ % or more over @ weeks .", "sentence_id": 3}
+{"abstract_id": "24937643", "label": "results", "text": "Sixty patients ( @ men ; mean age , @ @ yr ) , with a mean pulmonary artery pressure of @ ( @ ) mm Hg , PVRi @ ( @ ) Wood Units/m ( @ ) and reduced cardiac index of @ ( @ ) L/min/m ( @ ) were recruited to the study .", "sentence_id": 4}
+{"abstract_id": "24937643", "label": "results", "text": "Accounting for deaths and withdrawals , paired right heart catheter data were available for analysis in @ patients ( bosentan = @ , placebo = @ ) .", "sentence_id": 5}
+{"abstract_id": "24937643", "label": "results", "text": "No difference in the primary outcome was detected , with seven ( @ % ) patients receiving bosentan , and four ( @ % ) receiving placebo achieving a reduction in PVRi of greater than or equal to @ % ( P = @ ) at @ weeks .", "sentence_id": 6}
+{"abstract_id": "24937643", "label": "results", "text": "There was no change in functional capacity or symptoms between the two groups at @ weeks , nor any difference in rates of serious adverse events or deaths ( three deaths in each group ) .", "sentence_id": 7}
+{"abstract_id": "24937643", "label": "conclusions", "text": "This study shows no difference in invasive pulmonary hemodynamics , functional capacity , or symptoms between the bosentan and placebo groups over @ weeks .", "sentence_id": 8}
+{"abstract_id": "24937643", "label": "conclusions", "text": "Our data do not support the use of the dual endothelin-@ receptor antagonist , bosentan , in patients with PH and fibrotic IIP .", "sentence_id": 9}
+{"abstract_id": "24937643", "label": "conclusions", "text": "Clinical trial registered with www.clinicaltrials.gov ( NCT @ ) .", "sentence_id": 10}
+{"abstract_id": "24798770", "label": "background", "text": "The integrase inhibitor dolutegravir and nucleoside analogues abacavir and lamivudine are once-daily treatment options for HIV .", "sentence_id": 0}
+{"abstract_id": "24798770", "label": "background", "text": "This study ( NCT@ ) evaluated , first , the bioequivalence ( BE ) of a fixed-dose combination ( FDC ) tablet containing dolutegravir @ mg , abacavir @ mg , and lamivudine @ mg ( dolutegravir/abacavir/lamivudine FDC ) vs coadministered dolutegravir @ mg and abacavir/lamivudine combination tablets ( Epzicom ) and , second , the effect of food on the dolutegravir/abacavir/lamivudine FDC tablet .", "sentence_id": 1}
+{"abstract_id": "24798770", "label": "methods", "text": "Study part A ( @ healthy subjects ) was a single-dose , open-label , randomized , @-period crossover study to evaluate the BE of the dolutegravir/abacavir/lamivudine FDC tablet and dolutegravir + abacavir/lamivudine tablets in the fasted state .", "sentence_id": 2}
+{"abstract_id": "24798770", "label": "methods", "text": "In study part B , @ subjects from part A received the dolutegravir/abacavir/lamivudine FDC tablet with a high-fat meal .", "sentence_id": 3}
+{"abstract_id": "24798770", "label": "methods", "text": "BE and food effect were assessed by analysis of variance to determine the ratio of geometric least squares means and associated @ % confidence intervals for key pharmacokinetic parameters for each of dolutegravir , abacavir , and lamivudine .", "sentence_id": 4}
+{"abstract_id": "24798770", "label": "results", "text": "Sixty-two subjects completed part A.", "sentence_id": 5}
+{"abstract_id": "24798770", "label": "results", "text": "The dolutegravir/abacavir/lamivudine tablet was bioequivalent to the dolutegravir + abacavir/lamivudine tablets ; @ % confidence intervals for the geometric least squares mean ratios fell within the @-@ @ BE criteria .", "sentence_id": 6}
+{"abstract_id": "24798770", "label": "results", "text": "The effect of food on the dolutegravir/abacavir/lamivudine FDC tablet was similar to previous food effects observed with the separate formulations .", "sentence_id": 7}
+{"abstract_id": "24798770", "label": "results", "text": "The safety profile was comparable between treatments , with no observed serious or grade @/@ adverse events .", "sentence_id": 8}
+{"abstract_id": "24798770", "label": "conclusions", "text": "The BE of the dolutegravir/abacavir/lamivudine FDC tablet was demonstrated ; it may be administered without regard to meals .", "sentence_id": 9}
+{"abstract_id": "25620670", "label": "objective", "text": "Crohn 's disease ( CD ) usually recurs after intestinal resection ; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence .", "sentence_id": 0}
+{"abstract_id": "25620670", "label": "objective", "text": "We investigated whether monitoring levels of fecal calprotectin ( FC ) can substitute for endoscopic analysis of the mucosa .", "sentence_id": 1}
+{"abstract_id": "25620670", "label": "methods", "text": "We analyzed data collected from @ participants in a prospective , randomized , controlled trial , performed at @ hospitals in Australia and @ hospital in New Zealand , that assessed the ability of endoscopic evaluations and step-up treatment to prevent CD recurrence after surgery .", "sentence_id": 2}
+{"abstract_id": "25620670", "label": "methods", "text": "Levels of FC , serum levels of C-reactive protein ( CRP ) , and Crohn 's disease activity index ( CDAI ) scores were measured before surgery and then at @ , @ , and @ months after resection of all macroscopic Crohn 's disease .", "sentence_id": 3}
+{"abstract_id": "25620670", "label": "methods", "text": "Ileocolonoscopies were performed at @ months after surgery in @ patients and at @ months after surgery in all patients .", "sentence_id": 4}
+{"abstract_id": "25620670", "label": "results", "text": "Levels of FC were measured in @ samples from @ patients .", "sentence_id": 5}
+{"abstract_id": "25620670", "label": "results", "text": "The median FC level decreased from @ g/g before surgery to @ g/g at @ months after surgery , but was higher in patients with disease recurrence ( based on endoscopic analysis ; Rutgeerts score , i@ ) than in patients in remission ( @ vs @ g/g , respectively ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25620670", "label": "results", "text": "Combined @ - and @-month levels of FC correlated with the presence ( r = @ ; P < @ ) and severity ( r = @ ; P < @ ) of CD recurrence , but the CRP level and CDAI score did not .", "sentence_id": 7}
+{"abstract_id": "25620670", "label": "results", "text": "Levels of FC greater than @ g/g indicated endoscopic recurrence with @ % sensitivity and @ % specificity , and a negative predictive value ( NPV ) of @ % ; this means that colonoscopy could have been avoided in @ % of patients .", "sentence_id": 8}
+{"abstract_id": "25620670", "label": "results", "text": "Six months after surgery , FC levels less than @ g/g in patients in endoscopic remission predicted maintenance of remission ( NPV , @ % ) .", "sentence_id": 9}
+{"abstract_id": "25620670", "label": "results", "text": "In patients with endoscopic recurrence at @ months who stepped-up treatment , FC levels decreased from @ g/g at @ months to @ g/g at @ months and @ g/g at @ months .", "sentence_id": 10}
+{"abstract_id": "25620670", "label": "conclusions", "text": "In this analysis of data from a prospective clinical trial , FC measurement has sufficient sensitivity and NPV values to monitor for CD recurrence after intestinal resection .", "sentence_id": 11}
+{"abstract_id": "25620670", "label": "conclusions", "text": "Its predictive value might be used to identify patients most likely to relapse .", "sentence_id": 12}
+{"abstract_id": "25620670", "label": "conclusions", "text": "After treatment for recurrence , the FC level can be used to monitor response to treatment .", "sentence_id": 13}
+{"abstract_id": "25620670", "label": "conclusions", "text": "It predicts which patients will have disease recurrence with greater accuracy than CRP level or CDAI score .", "sentence_id": 14}
+{"abstract_id": "24625010", "label": "background", "text": "Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia .", "sentence_id": 0}
+{"abstract_id": "24625010", "label": "background", "text": "Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol , which should include score interpretation and verification with appropriately suggested treatments .", "sentence_id": 1}
+{"abstract_id": "24625010", "label": "background", "text": "The Observational Pain Management Protocol ( Protocol ) was therefore developed .", "sentence_id": 2}
+{"abstract_id": "24625010", "label": "background", "text": "This study aims to investigate the extent to which the implementation of this Protocol can improve pain management in care home residents with dementia .", "sentence_id": 3}
+{"abstract_id": "24625010", "label": "methods", "text": "In this two-group , single-blinded , cluster-randomized controlled trial , @ care home residents with dementia and pain-related diagnoses will be recruited from eight care homes ( that is @ to @ residents from each care home ) .", "sentence_id": 4}
+{"abstract_id": "24625010", "label": "methods", "text": "Invitations will be sent to all local care homes who meet the home selection criteria .", "sentence_id": 5}
+{"abstract_id": "24625010", "label": "methods", "text": "The eight care homes will be randomly selected from all care homes that agree to join this trial .", "sentence_id": 6}
+{"abstract_id": "24625010", "label": "methods", "text": "They will then be randomized to either the control or experimental conditions .", "sentence_id": 7}
+{"abstract_id": "24625010", "label": "methods", "text": "Participants from each care home will be placed into their home 's corresponding group to avoid ` contamination ' effects across participants .", "sentence_id": 8}
+{"abstract_id": "24625010", "label": "methods", "text": "Each intervention cycle will take @ weeks ( that is , baseline assessment and care home staff training for @ weeks and Protocol implementation for @ weeks ) .", "sentence_id": 9}
+{"abstract_id": "24625010", "label": "methods", "text": "The Protocol will guide the pain management of the participants in the experimental care homes .", "sentence_id": 10}
+{"abstract_id": "24625010", "label": "methods", "text": "Meanwhile , the control care homes will continue their usual pain management strategies .", "sentence_id": 11}
+{"abstract_id": "24625010", "label": "methods", "text": "Intervention effects will be measured weekly during the protocol implementation period and compared with the baseline measurements , as well as between the experimental and control conditions .", "sentence_id": 12}
+{"abstract_id": "24625010", "label": "conclusions", "text": "Although similar pain protocols have been suggested previously , the recommendations were based on experts ' opinions rather than evaluation of research studies .", "sentence_id": 13}
+{"abstract_id": "24625010", "label": "conclusions", "text": "The feasibility and effectiveness of this kind of pain management protocol , tailored to older people with dementia , remains unknown .", "sentence_id": 14}
+{"abstract_id": "24625010", "label": "conclusions", "text": "The findings of this trial will offer strong evidence that better strategies for pain management should be used in the care home daily routine .", "sentence_id": 15}
+{"abstract_id": "24628553", "label": "background", "text": "Dietary protein digestion and absorption is an important factor modulating muscle protein accretion .", "sentence_id": 0}
+{"abstract_id": "24628553", "label": "background", "text": "However , there are few data available on the effects of coingesting other macronutrients with protein on digestion and absorption kinetics and the subsequent muscle protein synthetic response .", "sentence_id": 1}
+{"abstract_id": "24628553", "label": "objective", "text": "The objective of the study was to determine the impact of carbohydrate coingestion with protein on dietary protein digestion and absorption and muscle protein accretion in healthy young and older men .", "sentence_id": 2}
+{"abstract_id": "24628553", "label": "methods", "text": "Twenty-four healthy young ( aged @ @ y , body mass index @ @ kg/m ( @ ) ) and @ older ( aged @ @ y , body mass index @ @ kg/m ( @ ) ) men received a primed continuous L - -LSB- ring - ( @ ) H@ -RSB- - phenylalanine and L - -LSB- ring-@ ,@ - ( @ ) H@ -RSB- - tyrosine infusion and ingested @ g intrinsically L - -LSB- @ - ( @ ) C -RSB- - phenylalanine-labeled protein with ( Pro + CHO ) or without ( Pro ) @ g carbohydrate .", "sentence_id": 3}
+{"abstract_id": "24628553", "label": "methods", "text": "Plasma samples and muscle biopsies were collected in a postabsorptive and postprandial state .", "sentence_id": 4}
+{"abstract_id": "24628553", "label": "results", "text": "Carbohydrate coingestion delayed the appearance of exogenous phenylalanine in the circulation ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24628553", "label": "results", "text": "Dietary protein-derived phenylalanine availability over the @-hour postprandial period was lower in the older ( @ @ % ) when compared with the young subjects ( @ @ % ; P = @ ) , with no differences between conditions ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24628553", "label": "results", "text": "Carbohydrate coingestion did not modulate postprandial muscle protein synthesis rates ( @ @ vs @ @ and @ @ vs @ @ % / h after Pro vs Pro + CHO in the young and older group , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24628553", "label": "results", "text": "In accordance , no differences in muscle protein-bound L - -LSB- @ - ( @ ) C -RSB- - phenylalanine enrichments were observed between conditions ( @ @ vs @ @ and @ @ vs @ @ mole percent excess after Pro vs Pro + CHO in the young and older subjects , respectively ) .", "sentence_id": 8}
+{"abstract_id": "24628553", "label": "conclusions", "text": "Carbohydrate coingestion with protein delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion in healthy young or older men .", "sentence_id": 9}
+{"abstract_id": "24460223", "label": "objective", "text": "Intrusive thoughts and images are common across the adult lifespan , but vary in their consequences .", "sentence_id": 0}
+{"abstract_id": "24460223", "label": "objective", "text": "Understanding age-related experiences with intrusive thoughts is important for identifying risk and protective factors for intrusive thought problems across the adult lifespan .", "sentence_id": 1}
+{"abstract_id": "24460223", "label": "objective", "text": "This study characterized age trajectories for six aspects of experiences with intrusive thoughts using Internet data collection .", "sentence_id": 2}
+{"abstract_id": "24460223", "label": "methods", "text": "Participants ( N = @ ; ages @-@ ) were randomly assigned to suppress ( i.e. keep out of mind ) or monitor an intrusive thought for one minute , and then later to monitor the thought for a second minute .", "sentence_id": 3}
+{"abstract_id": "24460223", "label": "methods", "text": "Participants tracked thought recurrences during each thinking period , then reported their positive and negative affects following each thinking period , as well as their effort expended in suppressing the thought and perceived difficulty controlling the intrusive thought .", "sentence_id": 4}
+{"abstract_id": "24460223", "label": "methods", "text": "Multilevel modeling and generalized estimating equations modeled the continuous relationships between age and each dependent variable .", "sentence_id": 5}
+{"abstract_id": "24460223", "label": "results", "text": "As expected , older age was associated with less decline in positive affect while engaging with an intrusive thought .", "sentence_id": 6}
+{"abstract_id": "24460223", "label": "results", "text": "Interestingly , older age was also associated with a sharper rise and fall of negative affect .", "sentence_id": 7}
+{"abstract_id": "24460223", "label": "results", "text": "Suppression effort increased linearly with age ( though perceived difficulty did not ) .", "sentence_id": 8}
+{"abstract_id": "24460223", "label": "results", "text": "Finally , no age differences were found in either the frequency or duration of the thought 's recurrence , adding to previous evidence that older adults function similarly to younger adults in their control of intrusive thoughts , despite certain age-related declines in cognitive functioning .", "sentence_id": 9}
+{"abstract_id": "24460223", "label": "conclusions", "text": "These findings suggest a dissociation between age-related changes in emotional versus cognitive characteristics of engaging with intrusive thoughts .", "sentence_id": 10}
+{"abstract_id": "24659510", "label": "background", "text": "Screening to prevent sudden cardiac death remains a contentious topic in sport and exercise medicine .", "sentence_id": 0}
+{"abstract_id": "24659510", "label": "background", "text": "The aim of this study was to assess whether the use of a standardised criteria tool improves the accuracy of ECG interpretation by physicians screening athletes .", "sentence_id": 1}
+{"abstract_id": "24659510", "label": "methods", "text": "Design : Randomised control trial .", "sentence_id": 2}
+{"abstract_id": "24659510", "label": "methods", "text": "Study Population : General practitioners with an interest in sports medicine , sports physicians , sports medicine registrars and cardiologists from Australia and New Zealand were eligible to participate .", "sentence_id": 3}
+{"abstract_id": "24659510", "label": "methods", "text": "Outcome Measures : Accuracy , sensitivity , specificity and false-positive rates of screening ECG interpretation of athletes .", "sentence_id": 4}
+{"abstract_id": "24659510", "label": "methods", "text": "Intervention : A two-page standardised ECG criteria tool was provided to intervention participants .", "sentence_id": 5}
+{"abstract_id": "24659510", "label": "methods", "text": "Control participants undertook ` usual ' interpretation .", "sentence_id": 6}
+{"abstract_id": "24659510", "label": "results", "text": "@ physicians , with a mean duration of practice of @years , were randomised to intervention and control .", "sentence_id": 7}
+{"abstract_id": "24659510", "label": "results", "text": "@ baseline and @ postrandomisation athlete ECGs were interpreted by the participants .", "sentence_id": 8}
+{"abstract_id": "24659510", "label": "results", "text": "Intervention participants were more likely to be correct : OR @ ( @ % CI @ to @ , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24659510", "label": "results", "text": "Correct ECG interpretation was higher in the intervention group , @ % ( @ % CI @ % to @ % ) , than in the control group , @ % ( @ % CI @ % to @ % ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24659510", "label": "results", "text": "Sensitivity was @ % in the intervention group and @ % in the control group ( p = @ ) , with specificity of @ % and @ % , respectively ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24659510", "label": "results", "text": "There were @ % fewer false positives in the intervention group ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24659510", "label": "conclusions", "text": "ECG interpretation in athletes can be improved by using a standardised ECG criteria tool .", "sentence_id": 13}
+{"abstract_id": "24659510", "label": "conclusions", "text": "Use of the tool results in lower false-positive rates ; this may have implications for screening recommendations .", "sentence_id": 14}
+{"abstract_id": "24288077", "label": "objective", "text": "Anterior knee pain is a major cause of complaint in total knee arthroplasty ( TKA ) without patellar resurfacing .", "sentence_id": 0}
+{"abstract_id": "24288077", "label": "objective", "text": "The concept of improved patellar tracking and decreased retropatellar contact pressure for lateral retinacular release theoretically suggests that patients with lateral retinacular release in TKA would achieve a lower incidence of anterior knee pain when compared without lateral retinacular release .", "sentence_id": 1}
+{"abstract_id": "24288077", "label": "objective", "text": "We sought to determine ( @ ) whether those patients who received a routine lateral retinacular release in TKA would attain lower incidence of anterior knee pain as compared to patients who received TKA without lateral retinacular release and ( @ ) whether lateral retinacular release would increase the lateral retinacular release-related complications .", "sentence_id": 2}
+{"abstract_id": "24288077", "label": "methods", "text": "A total of @ patients who underwent TKA with the use of the Gemini MK II mobile bearing were randomized to receive either routine lateral retinacular release ( intervention group ) or not ( control group ) .", "sentence_id": 3}
+{"abstract_id": "24288077", "label": "methods", "text": "Patients were assessed by the visual analogue scale for anterior knee pain , the Knee Society clinical scoring system of knee score and function score , and patellar score for clinical function .", "sentence_id": 4}
+{"abstract_id": "24288077", "label": "methods", "text": "Patients ' satisfaction and lateral retinacular release-related complications were also evaluated .", "sentence_id": 5}
+{"abstract_id": "24288077", "label": "results", "text": "The overall incidence of anterior knee pain in the intervention group at @ months follow-up was @ % , while that of the control group was @ % ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24288077", "label": "results", "text": "No statistical difference was detected between the two groups in terms of lateral retinacular release-related complications ( n.s. ) , patients ' satisfaction ( n.s. ) , knee score ( n.s. ) , function score ( n.s. ) , and patellar score ( n.s. ) at @ months follow-up .", "sentence_id": 7}
+{"abstract_id": "24288077", "label": "conclusions", "text": "The present study suggests that routine lateral retinacular release can reduce anterior knee pain and does not increase lateral retinacular release-related complications , in TKA with the use of the Gemini MK II mobile bearing without patellar resurfacing .", "sentence_id": 8}
+{"abstract_id": "24288077", "label": "methods", "text": "Therapeutic , Level I.", "sentence_id": 9}
+{"abstract_id": "25192478", "label": "objective", "text": "This study was undertaken to investigate whether a gradual reduction of the valve setting ( opening pressure ) decreases the complication rate in patients with idiopathic normal-pressure hydrocephalus ( iNPH ) treated with a ventriculoperitoneal ( VP ) shunt .", "sentence_id": 0}
+{"abstract_id": "25192478", "label": "methods", "text": "In this prospective double-blinded , randomized , controlled , dual-center study , a VP shunt with an adjustable valve was implanted in @ patients with iNPH , randomized into two groups .", "sentence_id": 1}
+{"abstract_id": "25192478", "label": "methods", "text": "In one group ( the @-@ group ) the valve setting was initially set to @ cm HO and gradually reduced to @ cm H@O over the course of the @-month study period .", "sentence_id": 2}
+{"abstract_id": "25192478", "label": "methods", "text": "In the other group ( the @ group ) , the valve was kept at a medium pressure setting of @ cm HO during the whole study period .", "sentence_id": 3}
+{"abstract_id": "25192478", "label": "methods", "text": "The time to and type of complications ( hematoma , infection , and mechanical problems ) as well as overdrainage symptoms were recorded .", "sentence_id": 4}
+{"abstract_id": "25192478", "label": "methods", "text": "Symptoms , signs , and outcome were assessed by means of the iNPH scale and the NPH grading scale .", "sentence_id": 5}
+{"abstract_id": "25192478", "label": "results", "text": "Six patients in the @-@ group ( @ % ) and @ patients in the @ group ( @ % ) experienced a shunt complication ; @ had subdural hematomas , @ mechanical obstructions , and @ infection ( no significant difference between groups ) .", "sentence_id": 6}
+{"abstract_id": "25192478", "label": "results", "text": "The frequency of overdrainage symptoms was significantly higher for a valve setting @ cm HO compared with a setting > @ cm HO .", "sentence_id": 7}
+{"abstract_id": "25192478", "label": "results", "text": "The @-@ group had a higher improvement rate ( @ % ) than the @ group ( @ % ) ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25192478", "label": "results", "text": "There was no significant relationship between complications and body mass index , the use of an antisiphon device , or the use of anticoagulants .", "sentence_id": 9}
+{"abstract_id": "25192478", "label": "conclusions", "text": "Gradual lowering of the valve setting to a mean of @ cm HO led to the same rate of shunt complications and overdrainage symptoms as a fixed valve setting at a mean of @ cm HO but was associated with a significantly better outcome .", "sentence_id": 10}
+{"abstract_id": "25117173", "label": "objective", "text": "The combination of direct-acting antiviral agents in patients with chronic hepatitis C virus ( HCV ) infection has demonstrated clinical benefit ; however , evaluation of potential drug-drug interactions is required prior to therapy .", "sentence_id": 0}
+{"abstract_id": "25117173", "label": "methods", "text": "An open-label study assessed the pharmacokinetics and tolerability of the HCV NS@A replication complex inhibitor daclatasvir and the HCV NS@ protease inhibitor asunaprevir when co-administered in healthy subjects .", "sentence_id": 1}
+{"abstract_id": "25117173", "label": "methods", "text": "Daclatasvir @mg once daily and asunaprevir @mg twice daily were dosed for @days alone followed by combination dosing for @days at @mg once daily and @mg twice daily , respectively .", "sentence_id": 2}
+{"abstract_id": "25117173", "label": "methods", "text": "Further assessments were provided comparing exposures from the current study with those from studies in HCV-infected patients receiving either the same or higher doses of daclatasvir or asunaprevir administered alone or together .", "sentence_id": 3}
+{"abstract_id": "25117173", "label": "results", "text": "Dose-normalized daclatasvir and asunaprevir morning exposures were comparable with control in healthy subjects , with geometric mean area under the concentration-time curve ratios of @ ( @ % CI @-@ @ ) and @ ( @ % CI @-@ @ ) , respectively .", "sentence_id": 4}
+{"abstract_id": "25117173", "label": "results", "text": "In HCV patients daclatasvir and asunaprevir exposures were largely comparable , when administered together or alone .", "sentence_id": 5}
+{"abstract_id": "25117173", "label": "conclusions", "text": "Additional data support the conclusion that there is no clinically meaningful interaction between daclatasvir and asunaprevir in either healthy subjects or HCV-infected patients , including those also receiving peginterferon - / ribavirin , and that the combination of daclatasvir @mg once daily and asunaprevir @mg twice daily is generally well-tolerated .", "sentence_id": 6}
+{"abstract_id": "24408900", "label": "background", "text": "Simplified informed consent forms have been successful in improving patient satisfaction and decreasing patient anxiety .", "sentence_id": 0}
+{"abstract_id": "24408900", "label": "background", "text": "However , unsolved problems remain about whether these documents improve comprehension and satisfaction of patients with standard literacy skills .", "sentence_id": 1}
+{"abstract_id": "24408900", "label": "objective", "text": "s To investigate whether a detailed consent form explaining the key elements of informed consent , in comparison to a standard consent form , would increase the comprehension and satisfaction of adult cancer patients .", "sentence_id": 2}
+{"abstract_id": "24408900", "label": "methods", "text": "Patients who were eligible for the National Surgical Adjuvant Study of Breast Cancer ( protocol @ ( N-SAS/BC -@ ) ) were randomly selected to receive one of the following four versions : detailed document with graphics , detailed document without graphics , standard document with graphics , and standard document without graphics .", "sentence_id": 3}
+{"abstract_id": "24408900", "label": "methods", "text": "The forms were written in plain language from the patients ' point of view .", "sentence_id": 4}
+{"abstract_id": "24408900", "label": "methods", "text": "A total of @ patients were administered questionnaires via interview to assess levels of comprehension , satisfaction , and anxiety .", "sentence_id": 5}
+{"abstract_id": "24408900", "label": "results", "text": "Patients demonstrated a strong understanding of information regarding treatment and research .", "sentence_id": 6}
+{"abstract_id": "24408900", "label": "results", "text": "Patient comprehension did not differ significantly between the detailed document arms and the standard document arms .", "sentence_id": 7}
+{"abstract_id": "24408900", "label": "results", "text": "Patient satisfaction level increased according to the amount of information presented in the consent form ; most patients preferred the detailed document with graphics .", "sentence_id": 8}
+{"abstract_id": "24408900", "label": "results", "text": "Anxiety and accrual rates in the parent study were not affected by informed consent procedures .", "sentence_id": 9}
+{"abstract_id": "24408900", "label": "conclusions", "text": "Findings were limited to adults who had standard literacy skills and may not be generalizable to a population with lower literacy .", "sentence_id": 10}
+{"abstract_id": "24408900", "label": "conclusions", "text": "Informed consent can be a significant experience for a population with standard literacy skills , as long as the document is easily comprehensible .", "sentence_id": 11}
+{"abstract_id": "24408900", "label": "conclusions", "text": "Such information should be provided in a format that corresponds with patient needs , education levels , and preferences .", "sentence_id": 12}
+{"abstract_id": "24885811", "label": "background", "text": "Providing additional Saturday rehabilitation can improve functional independence and health related quality of life at discharge and it may reduce patient length of stay , yet the economic implications are not known .", "sentence_id": 0}
+{"abstract_id": "24885811", "label": "background", "text": "The aim of this study was to determine from a health service perspective if the provision of rehabilitation to inpatients on a Saturday in addition to Monday to Friday was cost effective compared to Monday to Friday rehabilitation alone .", "sentence_id": 1}
+{"abstract_id": "24885811", "label": "methods", "text": "Cost utility and cost effectiveness analyses were undertaken alongside a multi-center , single-blind randomized controlled trial with a @-day follow up after discharge .", "sentence_id": 2}
+{"abstract_id": "24885811", "label": "methods", "text": "Participants were adults admitted for inpatient rehabilitation in two publicly funded metropolitan rehabilitation facilities .", "sentence_id": 3}
+{"abstract_id": "24885811", "label": "methods", "text": "The control group received usual care rehabilitation services from Monday to Friday and the intervention group received usual care plus an additional rehabilitation service on Saturday .", "sentence_id": 4}
+{"abstract_id": "24885811", "label": "methods", "text": "Incremental cost utility ratio was reported as cost per quality adjusted life year ( QALY ) gained and an incremental cost effectiveness ratio ( ICER ) was reported as cost for a minimal clinically important difference ( MCID ) in functional independence .", "sentence_id": 5}
+{"abstract_id": "24885811", "label": "results", "text": "@ patients ( mean age @ ( standard deviation @ ) years ) were randomly assigned to the intervention ( n = @ ) or the control group ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24885811", "label": "results", "text": "Mean difference in cost of AUD$ @,@ ( @ % confidence interval ( CI ) -@ to @,@ ) was a saving in favor of the intervention group .", "sentence_id": 7}
+{"abstract_id": "24885811", "label": "results", "text": "The incremental cost utility ratio found a saving of AUD$ @,@ ( @ % CI -@,@ to @,@ ) per QALY gained for the intervention group .", "sentence_id": 8}
+{"abstract_id": "24885811", "label": "results", "text": "The ICER found a saving of AUD$ @,@ ( @ % CI -@,@ to @,@ ) in achieving a MCID in functional independence for the intervention group .", "sentence_id": 9}
+{"abstract_id": "24885811", "label": "results", "text": "If the willingness to pay per QALY gained or for a MCID in functional independence was zero dollars the probability of the intervention being cost effective was @ % and @ % , respectively .", "sentence_id": 10}
+{"abstract_id": "24885811", "label": "results", "text": "A sensitivity analysis removing Saturday penalty rates did not significantly alter the outcome .", "sentence_id": 11}
+{"abstract_id": "24885811", "label": "conclusions", "text": "From a health service perspective , the provision of rehabilitation to inpatients on a Saturday in addition to Monday to Friday , compared to Monday to Friday rehabilitation alone , is likely to be cost saving per QALY gained and for a MCID in functional independence .", "sentence_id": 12}
+{"abstract_id": "24671453", "label": "background", "text": "The maximal effect of proton pump inhibitors ( PPI ) is reported to take @ days .", "sentence_id": 0}
+{"abstract_id": "24671453", "label": "background", "text": "However , most current protocols start PPI on the day of gastric endoscopic submucosal dissection ( ESD ) .", "sentence_id": 1}
+{"abstract_id": "24671453", "label": "objective", "text": "We aimed to evaluate the benefit of @ days pretreatment with oral PPI before ESD to prevent bleeding .", "sentence_id": 2}
+{"abstract_id": "24671453", "label": "methods", "text": "This was a prospective randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "24671453", "label": "methods", "text": "Patients were administered oral rabeprazole @ mg or placebo twice daily for @ days before ESD .", "sentence_id": 4}
+{"abstract_id": "24671453", "label": "methods", "text": "Intravenous pantoprazole @ mg was administered @ h before ESD and at postprocedure day @ , and then oral rabeprazole @ mg was administered once daily .", "sentence_id": 5}
+{"abstract_id": "24671453", "label": "methods", "text": "Follow-up endoscopy was performed on days @ and @ .", "sentence_id": 6}
+{"abstract_id": "24671453", "label": "methods", "text": "Forty-eight-hour measurement of intragastric pH was performed in @ patients .", "sentence_id": 7}
+{"abstract_id": "24671453", "label": "methods", "text": "The primary endpoint was major bleeding related to ESD .", "sentence_id": 8}
+{"abstract_id": "24671453", "label": "results", "text": "One-hundred and twenty patients were enrolled .", "sentence_id": 9}
+{"abstract_id": "24671453", "label": "results", "text": "Of these , @ in the pretreatment and @ in the placebo group were analyzed .", "sentence_id": 10}
+{"abstract_id": "24671453", "label": "results", "text": "Each group had three cases of major bleeding .", "sentence_id": 11}
+{"abstract_id": "24671453", "label": "results", "text": "There were no significant differences in the ulcer healing rate .", "sentence_id": 12}
+{"abstract_id": "24671453", "label": "results", "text": "Intragastric pH percentage times greater than @ , @ , and @ were @ @ % , @ @ % , and @ @ % , respectively , in the pretreatment and @ @ % , @ @ % , and @ @ % , respectively , in the placebo group , without significant differences .", "sentence_id": 13}
+{"abstract_id": "24671453", "label": "conclusions", "text": "Preprocedural administration of rabeprazole offers no additional benefit over postprocedural administration alone in preventing major bleeding after gastric ESD .", "sentence_id": 14}
+{"abstract_id": "24761794", "label": "background", "text": "To determine the relationship between type three secretion genotype and fluoroquinolone resistance for P. aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial ( SCUT ) and for two laboratory strains , PA@ and PAO@ .", "sentence_id": 0}
+{"abstract_id": "24761794", "label": "methods", "text": "Confirmed P. aeruginosa isolates from the SCUT were divided into exoU ( + ) or exoU ( - ) .", "sentence_id": 1}
+{"abstract_id": "24761794", "label": "methods", "text": "The exoU ( + ) strains contained the gene encoding ExoU , a powerful phospholipase toxin delivered into host cells by the type three secretion system .", "sentence_id": 2}
+{"abstract_id": "24761794", "label": "methods", "text": "Isolates were then assessed for susceptibility to fluoroquinolone , cephalosporin , and aminoglycoside antibiotics using disk diffusion assays .", "sentence_id": 3}
+{"abstract_id": "24761794", "label": "methods", "text": "Etest was used to determine the MIC of moxifloxacin and other fluoroquinolones .", "sentence_id": 4}
+{"abstract_id": "24761794", "label": "methods", "text": "Laboratory isolates in which the exoU gene was added or deleted were also tested .", "sentence_id": 5}
+{"abstract_id": "24761794", "label": "results", "text": "A significantly higher proportion of exoU ( + ) strains were resistant to ciprofloxacin ( p = @ ) , gatifloxacin ( p = @ ) , and ofloxacin ( p = @ ) compared to exoU ( - ) isolates .", "sentence_id": 6}
+{"abstract_id": "24761794", "label": "results", "text": "There was no significant difference between exoU ( + ) or exoU ( - ) negative isolates with respect to susceptibility to other antibiotics except gentamicin .", "sentence_id": 7}
+{"abstract_id": "24761794", "label": "results", "text": "Infections involving resistant exoU ( + ) strains trended towards worse clinical outcome .", "sentence_id": 8}
+{"abstract_id": "24761794", "label": "results", "text": "Deletion or acquisition of exoU in laboratory isolates did not affect fluoroquinolone susceptibility .", "sentence_id": 9}
+{"abstract_id": "24761794", "label": "conclusions", "text": "Fluoroquinolone susceptibility of P. aeruginosa isolated from the SCUT is consistent with previous studies showing elevated resistance involving exoU encoding ( cytotoxic ) strains , and suggest worse clinical outcome from infections involving resistant isolates .", "sentence_id": 10}
+{"abstract_id": "24761794", "label": "conclusions", "text": "Determination of exoU expression in clinical isolates of P. aeruginosa may be helpful in directing clinical management of patients with microbial keratitis .", "sentence_id": 11}
+{"abstract_id": "25535265", "label": "objective", "text": "Few evidence-based interventions address adolescent relationship abuse in clinical settings .", "sentence_id": 0}
+{"abstract_id": "25535265", "label": "objective", "text": "This cluster randomized controlled trial tested the effectiveness of a brief relationship abuse education and counseling intervention in school health centers ( SHCs ) .", "sentence_id": 1}
+{"abstract_id": "25535265", "label": "methods", "text": "In @-@ , @ SHCs ( @ clusters ) were randomized to intervention ( SHC providers received training to implement ) or standard-of-care control condition .", "sentence_id": 2}
+{"abstract_id": "25535265", "label": "methods", "text": "Among @ eligible students ages @ to @ years at @ SHCs who continued participation after randomization , @ completed computer-assisted surveys before a clinic visit ; @ completed surveys @ months later ( @ % retention ) .", "sentence_id": 3}
+{"abstract_id": "25535265", "label": "results", "text": "Intervention versus control adjusted mean differences ( @ % confidence interval ) on changes in primary outcomes were not statistically significant : recognition of abuse = @ ( -@ to @ ) ; intentions to intervene = @ ( -@ to @ ) ; and knowledge of resources = @ ( -@ to @ ) .", "sentence_id": 4}
+{"abstract_id": "25535265", "label": "results", "text": "Intervention participants had improved recognition of sexual coercion compared with controls ( adjusted mean difference = @ -LSB- @ to @ -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "25535265", "label": "results", "text": "In exploratory analyses adjusting for intensity of intervention uptake , intervention effects were significant for increased knowledge of relationship abuse resources and self-efficacy to use harm reduction behaviors .", "sentence_id": 6}
+{"abstract_id": "25535265", "label": "results", "text": "Among participants reporting relationship abuse at baseline , intervention participants were less likely to report such abuse at follow-up ( mean risk difference = -@ -LSB- -@ to -@ -RSB- ) .", "sentence_id": 7}
+{"abstract_id": "25535265", "label": "results", "text": "Adolescents in intervention clinics who reported ever being in an unhealthy relationship were more likely to report disclosing this during the SHC visit ( adjusted odds ratio = @ -LSB- @ to @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "25535265", "label": "conclusions", "text": "This is the first evidence of the potential benefit of a SHC intervention to address abusive relationships among adolescents .", "sentence_id": 9}
+{"abstract_id": "25467040", "label": "objective", "text": "To assess bacterial colonization following balloon uterine stent placement in the uterus for @ days .", "sentence_id": 0}
+{"abstract_id": "25467040", "label": "methods", "text": "Prospective randomized controlled study .", "sentence_id": 1}
+{"abstract_id": "25467040", "label": "methods", "text": "Tertiary medical center .", "sentence_id": 2}
+{"abstract_id": "25467040", "label": "methods", "text": "Sixty-eight women scheduled for hysteroscopy .", "sentence_id": 3}
+{"abstract_id": "25467040", "label": "methods", "text": "Women who were undergoing hysteroscopic surgery were randomly assigned to receive a balloon uterine stent or not .", "sentence_id": 4}
+{"abstract_id": "25467040", "label": "methods", "text": "Before starting surgery , the uterine cavity was swabbed for bacterial culture .", "sentence_id": 5}
+{"abstract_id": "25467040", "label": "methods", "text": "The device was placed in the uterus after surgery in the stent group .", "sentence_id": 6}
+{"abstract_id": "25467040", "label": "methods", "text": "After @ days , the stent was removed and sent for culture and the uterine cavity also swabbed and cultured .", "sentence_id": 7}
+{"abstract_id": "25467040", "label": "methods", "text": "The uterine cavities of the control patients were swabbed before and @ days after surgery .", "sentence_id": 8}
+{"abstract_id": "25467040", "label": "methods", "text": "The primary outcome was the incidence of bacterial colonization of the uterus .", "sentence_id": 9}
+{"abstract_id": "25467040", "label": "methods", "text": "Secondary outcomes were pain intensity and species of colonizing bacteria .", "sentence_id": 10}
+{"abstract_id": "25467040", "label": "results", "text": "Excluding eight women , @ women in each group were included in this analysis .", "sentence_id": 11}
+{"abstract_id": "25467040", "label": "results", "text": "In the stent group , three women ( @ % ) demonstrated bacterial colonization before surgery compared with nine women ( @ % ) after @ days .", "sentence_id": 12}
+{"abstract_id": "25467040", "label": "results", "text": "In the control group , four ( @ % ) and ten ( @ % ) women had microorganisms detected in the uterus before and after @ days after surgery , respectively .", "sentence_id": 13}
+{"abstract_id": "25467040", "label": "results", "text": "In neither group did the percentage of women with uterine microorganisms increase significantly after @ days .", "sentence_id": 14}
+{"abstract_id": "25467040", "label": "results", "text": "The percentages of women with uterine bacterial colonization before and @ days after surgery were similar between both groups .", "sentence_id": 15}
+{"abstract_id": "25467040", "label": "conclusions", "text": "Balloon uterine stents may be placed after surgery for up to @ days without increasing bacterial colonization .", "sentence_id": 16}
+{"abstract_id": "24582914", "label": "background", "text": "RAS mutations predict resistance to anti-epidermal growthfactor receptor ( EGFR ) monoclonal antibodies in metastatic colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "24582914", "label": "background", "text": "We analysed RAS mutations in @ non-metastatic rectal cancer patients treated with or without cetuximab within the @ EXPERT-C trial .", "sentence_id": 1}
+{"abstract_id": "24582914", "label": "methods", "text": "Ninety of @ patients with tumours available for analysis were KRAS/BRAF wild-type , and randomly assigned to capecitabine plus oxaliplatin ( CAPOX ) followed by chemoradiotherapy , surgery and adjuvant CAPOX or the same regimen plus cetuximab ( CAPOX-C ) .", "sentence_id": 2}
+{"abstract_id": "24582914", "label": "methods", "text": "Of these , four had a mutation of NRAS exon @ , and @ were retrospectively analysed for additional KRAS ( exon @ ) and NRAS ( exons @/@ ) mutations by using bi-directional Sanger sequencing .", "sentence_id": 3}
+{"abstract_id": "24582914", "label": "methods", "text": "The effect of cetuximab on study end-points in the RAS wild-type population was analysed .", "sentence_id": 4}
+{"abstract_id": "24582914", "label": "results", "text": "Eleven ( @ % ) of @ patients initially classified as KRAS/BRAF wild-type were found to have a mutation in KRAS exon @ ( @ % ) or NRAS exons @/@ ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "24582914", "label": "results", "text": "Overall , @/@ ( @ % ) assessable patients were RAS wild-type ( CAPOX , n = @ ; CAPOX-C , n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24582914", "label": "results", "text": "In this population , after a median follow-up of @ months , in line with the initial analysis , the addition of cetuximab was associated with numerically higher , but not statistically significant , rates of complete response ( @ % versus @ % , p = @ ) , @-year progression-free survival ( @ % versus @ % , hazard ratio ( HR ) @ , p = @ ) and @-year overall survival ( @ % versus @ % , HR @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24582914", "label": "conclusions", "text": "RAS mutations beyond KRAS exon @ and @ were identified in @ % of locally advanced rectal cancer patients .", "sentence_id": 8}
+{"abstract_id": "24582914", "label": "conclusions", "text": "Given the small sample size , no definitive conclusions on the effect of additional RAS mutations on cetuximab treatment in this setting can be drawn and further investigation of RAS in larger studies is warranted .", "sentence_id": 9}
+{"abstract_id": "25544167", "label": "objective", "text": "To observe the therapeutic effect of extracorporeal shock wave combined with orthopaedic insole on plantar fasciitis .", "sentence_id": 0}
+{"abstract_id": "25544167", "label": "methods", "text": "A total of @ plantar with plantar fasciitis were randomly divided into a combined group ( n = @ ) , an extracorporeal shock wave group ( n = @ ) and an orthopaedic group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25544167", "label": "methods", "text": "The combined group received treatment of both extracorporeal shock wave and orthopaedic insole while the extracorporeal shock wave or the orthopaedic group only received the treatment of extracorporeal shock wave or orthopaedic insole .", "sentence_id": 2}
+{"abstract_id": "25544167", "label": "methods", "text": "The therapeutic parameters such as visual analogue scale ( VAS ) scores , continued walking time and thickness of the plantar fascia were monitored before and aft er the treatment for @ weeks , @ month and @ months , respectively .", "sentence_id": 3}
+{"abstract_id": "25544167", "label": "results", "text": "The VAS scores in the @ groups were all reduced after the treatment compared with the corresponding scores before the therapy ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25544167", "label": "results", "text": "The VAS score in the extracorporeal shock wave group was greater than that in the orthopedic group after the treatment for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25544167", "label": "results", "text": "The VAS score in the combined group was smaller than that in the orthopedic group after the treatment for @ weeks and @ months ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25544167", "label": "results", "text": "The VAS scores in the orthopedic group and the combined group were smaller than those in the extracorporeal shock wave group after the treatment for @ month or @ months ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25544167", "label": "results", "text": "The continued walking time and thickness of the plantar fascia was improved after the treatment ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25544167", "label": "results", "text": "The cure rate and total effective rate in the combination group were obviously greater than those in the two other groups .", "sentence_id": 9}
+{"abstract_id": "25544167", "label": "results", "text": "The cure rate in the orthopedic group was greater than that in the extracorporeal shock wave group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25544167", "label": "conclusions", "text": "Extracorporeal shock wave combined with orthopaedic insole therapy is an effective method to treat plantar fasciitis .", "sentence_id": 11}
+{"abstract_id": "25544167", "label": "conclusions", "text": "It is recommended to spread in clinic .", "sentence_id": 12}
+{"abstract_id": "24817030", "label": "objective", "text": "The efficacy of noninvasive continuous positive airway pressure ( CPAP ) to improve outcomes in severe hypoxemic acute respiratory failure ( hARF ) due to pneumonia has not been clearly established .", "sentence_id": 0}
+{"abstract_id": "24817030", "label": "objective", "text": "The aim of this study was to compare CPAP vs. oxygen therapy to reduce the risk of meeting criteria for endotracheal intubation ( ETI ) .", "sentence_id": 1}
+{"abstract_id": "24817030", "label": "methods", "text": "In a multicenter randomized controlled trial conducted in four Italian centers patients with severe hARF due to pneumonia were randomized to receive helmet CPAP ( CPAP group ) or oxygen delivered with a Venturi mask ( control group ) .", "sentence_id": 2}
+{"abstract_id": "24817030", "label": "methods", "text": "The primary endpoint was the percentage of patients meeting criteria for ETI , including either one or more major criteria ( respiratory arrest , respiratory pauses with unconsciousness , severe hemodynamic instability , intolerance ) or at least two minor criteria ( reduction of at least @ % of basal PaO@/FiO@ ratio , increase of @ % of PaCO@ , worsening of alertness , respiratory distress , SpO@ less than @ % , exhaustion ) .", "sentence_id": 3}
+{"abstract_id": "24817030", "label": "results", "text": "Between February @ and @ , @ patients were randomized to CPAP and @ to Venturi mask .", "sentence_id": 4}
+{"abstract_id": "24817030", "label": "results", "text": "The proportion of patients meeting ETI criteria in the CPAP group was significantly lower compared to those in the control group ( @/@ = @ % vs. @/@ = @ % , respectively , p < @ ; relative risk @ , @ % CI @-@ @ ; number needed to treat , @ ) two patients were intubated in the CPAP group and one in the control group .", "sentence_id": 5}
+{"abstract_id": "24817030", "label": "results", "text": "The CPAP group showed a faster and greater improvement in oxygenation in comparison to controls ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24817030", "label": "results", "text": "In either study group , no relevant adverse events were detected .", "sentence_id": 7}
+{"abstract_id": "24817030", "label": "conclusions", "text": "Helmet CPAP reduces the risk of meeting ETI criteria compared to oxygen therapy in patients with severe hARF due to pneumonia .", "sentence_id": 8}
+{"abstract_id": "24280811", "label": "background", "text": "This randomized double-blind study was designed to compare palonosetron with palonosetron-dexamethasone combination for prevention of post operative nausea and vomiting ( PONV ) in patients undergoing laparoscopic cholecystectomy .", "sentence_id": 0}
+{"abstract_id": "24280811", "label": "methods", "text": "Eighty-four adult ASA @-@ patients were randomly allocated into two groups .", "sentence_id": 1}
+{"abstract_id": "24280811", "label": "methods", "text": "Group P patients received @ mg palonosetron and group PD patients received @ mg palonosetron and @ mg dexamethasone intravenously before induction of anesthesia .", "sentence_id": 2}
+{"abstract_id": "24280811", "label": "methods", "text": "Anesthesia was induced with propofol and fentanyl and maintained with N@O-isoflurane in oxygen .", "sentence_id": 3}
+{"abstract_id": "24280811", "label": "methods", "text": "All patients received port-site infiltration with bupivacaine and intravenous diclofenac for postoperative analgesia .", "sentence_id": 4}
+{"abstract_id": "24280811", "label": "methods", "text": "Metoclopramide was used as rescue antiemetic .", "sentence_id": 5}
+{"abstract_id": "24280811", "label": "methods", "text": "Patients were observed for the incidence of PONV and requirement of rescue antiemetic for @ h after surgery .", "sentence_id": 6}
+{"abstract_id": "24280811", "label": "results", "text": "The complete response rate ( no vomiting ) was significantly higher in group DP as compared to group P between @-@ h ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24280811", "label": "results", "text": "@ ( @ % ) patients reported nausea and @ ( @ % ) patients had vomiting in group P while @ ( @ % ) patients had nausea and @ ( @ % ) patients complained of vomiting in group DP during @-@ h. Two patients in group P reported nausea while none in group PD during @-@ h. No patient had vomiting in either of the groups between @-@ h.", "sentence_id": 8}
+{"abstract_id": "24280811", "label": "results", "text": "The requirement of rescue antiemetic was also less in group DP as compared to group P. Patients in group DP required less postoperative analgesia and were more satisfied with PONV treatment than group P patients .", "sentence_id": 9}
+{"abstract_id": "24280811", "label": "conclusions", "text": "The palonosetron-dexamethasone combination was more effective as compared to only palonosetron for reducing PONV after laparoscopic cholecystectomy .", "sentence_id": 10}
+{"abstract_id": "24241327", "label": "objective", "text": "A large number of unrepaired inguinal hernias is expected in sub-Saharan Africa where late presentation often results in incarceration , strangulation , or giant scrotal hernias .", "sentence_id": 0}
+{"abstract_id": "24241327", "label": "objective", "text": "However , no representative population-based data are available to quantify the prevalence of hernias .", "sentence_id": 1}
+{"abstract_id": "24241327", "label": "objective", "text": "We present data on groin masses in Sierra Leone to estimate prevalence , barriers to care , and associated disability .", "sentence_id": 2}
+{"abstract_id": "24241327", "label": "methods", "text": "A cluster randomized , cross-sectional household survey of @ clusters of @ households with @ respondents each was designed to calculate the prevalence of and disability caused by groin hernias in Sierra Leone using a verbal head-to-toe examination .", "sentence_id": 3}
+{"abstract_id": "24241327", "label": "methods", "text": "Barriers to hernia repairs were assessed by asking participants the main reason for delay in surgical care .", "sentence_id": 4}
+{"abstract_id": "24241327", "label": "results", "text": "Information was obtained from @,@ respondents in @,@ households , of which @,@ ( @ % ) were male and included in the study .", "sentence_id": 5}
+{"abstract_id": "24241327", "label": "results", "text": "In total , @ males or @ % ( @ % CI @-@ @ ) reported a soft or reducible swelling likely representing a hernia with four men having two masses .", "sentence_id": 6}
+{"abstract_id": "24241327", "label": "results", "text": "Of the @ % who indicated the need for health care , only @ % underwent a procedure , citing limited funds ( @ % ) as the major barrier to care .", "sentence_id": 7}
+{"abstract_id": "24241327", "label": "results", "text": "On disability assessment , @ % were not able to work secondary to the groin swelling .", "sentence_id": 8}
+{"abstract_id": "24241327", "label": "conclusions", "text": "The results indicate groin masses represent a major burden for the male population in Sierra Leone .", "sentence_id": 9}
+{"abstract_id": "24241327", "label": "conclusions", "text": "Improving access to surgical care for adult patients with hernias and early intervention for children will be vital to address the burden of disease and prevent complications or limitations of daily activity .", "sentence_id": 10}
+{"abstract_id": "24386447", "label": "background", "text": "Health IT can play a major role in improving patient safety .", "sentence_id": 0}
+{"abstract_id": "24386447", "label": "background", "text": "Computerized physician order entry with decision support can alert providers to potential prescribing errors .", "sentence_id": 1}
+{"abstract_id": "24386447", "label": "background", "text": "However , too many alerts can result in providers ignoring and overriding clinically important ones .", "sentence_id": 2}
+{"abstract_id": "24386447", "label": "objective", "text": "To evaluate the appropriateness of providers ' drug-drug interaction ( DDI ) alert overrides , the reasons why they chose to override these alerts , and what actions they took as a consequence of the alert .", "sentence_id": 3}
+{"abstract_id": "24386447", "label": "methods", "text": "A cross-sectional , observational study of DDI alerts generated over a three-year period between January @st , @ , and December @st , @ .", "sentence_id": 4}
+{"abstract_id": "24386447", "label": "methods", "text": "Primary care practices affiliated with two Harvard teaching hospitals .", "sentence_id": 5}
+{"abstract_id": "24386447", "label": "methods", "text": "The DDI alerts were screened to minimize the number of clinically unimportant warnings .", "sentence_id": 6}
+{"abstract_id": "24386447", "label": "methods", "text": "A total of @,@ DDI alerts were generated in the study period , with @ % accepted .", "sentence_id": 7}
+{"abstract_id": "24386447", "label": "methods", "text": "The top @ providers with the highest override rate were identified and eight overrides randomly selected for each ( a total of @ alert overrides for @ patients , @ % of the sample ) .", "sentence_id": 8}
+{"abstract_id": "24386447", "label": "results", "text": "Overall , @ % ( @/@ ) of the DDI alert overrides were considered appropriate .", "sentence_id": 9}
+{"abstract_id": "24386447", "label": "results", "text": "Among inappropriate overrides , the therapeutic combinations put patients at increased risk of several specific conditions including : serotonin syndrome ( @ % , n = @ ) , cardiotoxicity ( @ % , n = @ ) , or sharp falls in blood pressure or significant hypotension ( @ % , n = @ ) .", "sentence_id": 10}
+{"abstract_id": "24386447", "label": "results", "text": "A small number of drugs and DDIs accounted for a disproportionate share of alert overrides .", "sentence_id": 11}
+{"abstract_id": "24386447", "label": "results", "text": "Of the @ appropriate alert overrides where the provider indicated they would `` monitor as recommended '' , a detailed chart review revealed that only @ % ( n = @ ) actually did .", "sentence_id": 12}
+{"abstract_id": "24386447", "label": "results", "text": "Providers sometimes reported that patients had already taken interacting medications together ( @ % , n = @ ) , despite no evidence to confirm this .", "sentence_id": 13}
+{"abstract_id": "24386447", "label": "conclusions", "text": "We found that providers continue to override important and useful alerts that are likely to cause serious patient injuries , even when relatively few false positive alerts are displayed .", "sentence_id": 14}
+{"abstract_id": "25312783", "label": "objective", "text": "The treatment strategy for steroid-resistant nephrotic syndrome remains uncertain at present , especially in those with calcineurin inhibitor resistance or intolerance .", "sentence_id": 0}
+{"abstract_id": "25312783", "label": "objective", "text": "To date , few studies have been published using multiple combination therapy of immunosuppressive reagents for children with calcineurin inhibitor-resistant or - intolerant nephrotic syndrome .", "sentence_id": 1}
+{"abstract_id": "25312783", "label": "methods", "text": "Eighteen consecutive children with steroid - and tacrolimus ( TAC ) - resistant ( n = @ ) or TAC-sensitive but frequent relapsing nephrotic syndrome ( n = @ ) were randomly recruited in the present study .", "sentence_id": 2}
+{"abstract_id": "25312783", "label": "methods", "text": "All of them received further triple-combination therapy by cyclophosphamide ( CTX , n = @ ) , mycophenolate mofetil ( MMF , n = @ ) or leflunomide ( LEF , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25312783", "label": "methods", "text": "Their clinical data were collected and efficacy of triple-combination therapy was evaluated .", "sentence_id": 4}
+{"abstract_id": "25312783", "label": "results", "text": "Compared with previous double-combination therapy of prednisone ( Pre ) and TAC , the short-term remission rate in all @ patients was significantly improved after the triple-combination therapy , while the frequent relapse rate in the following @months was also significantly decreased .", "sentence_id": 5}
+{"abstract_id": "25312783", "label": "results", "text": "Among three different subgroups with CTX , MMF or LEF therapy , no significant difference was found in short-term remission rate and the relapse rate within @year follow up by Kaplan-Meier plot .", "sentence_id": 6}
+{"abstract_id": "25312783", "label": "conclusions", "text": "Triple-combination therapy with Pre + TAC+CTX / MMF/LEF is effective for short-term response and @year remission , without significant additional side-effects seen in children with steroid-resistant and tacrolimus-resistant or tacrolimus-sensitive but frequently relapsing nephrotic syndrome .", "sentence_id": 7}
+{"abstract_id": "25312783", "label": "conclusions", "text": "Further study for evaluating long-term efficacy and safety of triple-combination therapy with Pre + TAC+CTX / MMF/LEF would be necessary for these patients .", "sentence_id": 8}
+{"abstract_id": "24609848", "label": "background", "text": "Biospecimen collection from diverse populations can advance cancer disparities research , but is currently underrepresented .", "sentence_id": 0}
+{"abstract_id": "24609848", "label": "methods", "text": "We partnered with a community-based clinic serving Cantonese-speaking Chinese Americans to develop and revise an educational seminar on biospecimen collection .", "sentence_id": 1}
+{"abstract_id": "24609848", "label": "methods", "text": "Through a randomized controlled trial ( n = @ ) , the intervention seminar was compared with a control seminar ( cancer prevention ) on change in willingness to donate biospecimens .", "sentence_id": 2}
+{"abstract_id": "24609848", "label": "results", "text": "At baseline , many were willing to donate a biospecimen ( saliva , urine , hair , toenails , blood , unused cancerous tissue ) whether healthy or hypothetically had cancer .", "sentence_id": 3}
+{"abstract_id": "24609848", "label": "results", "text": "Also , many would donate because future generations would benefit , and few had concerns about donation .", "sentence_id": 4}
+{"abstract_id": "24609848", "label": "results", "text": "In logistic regression analyses , there was an intervention effect for willingness to donate : urine if had cancer -LSB- OR , @ ; @ % confidence interval ( CI ) , @-@ @ -RSB- , toenails if healthy ( OR , @ ; @ % CI , @-@ @ ) or had cancer ( OR , @ ; @ % CI , @-@ @ ) , hair if healthy ( OR , @ ; @ % CI , @-@ @ ) or had cancer ( OR , @ ; @ % CI , @-@ @ ) , and unused cancerous tissue ( OR , @ ; @ % CI , @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "24609848", "label": "results", "text": "There was also an intervention effect for donating because future generations would benefit ( OR , @ ; @ % CI , @-@ @ ) , and this attitude was a strong independent predictor for willingness to donate all biospecimens , whether healthy or had cancer ( OR , @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24609848", "label": "conclusions", "text": "Cantonese-speaking Chinese American participants of an educational seminar on biospecimen collection showed greater increases in willingness to donate biospecimens and donating for the benefit of future generations , than participants who attended a control seminar .", "sentence_id": 7}
+{"abstract_id": "24609848", "label": "conclusions", "text": "Donating for the benefit of future generations is a theme that should be incorporated in messages that encourage biospecimen donation for Chinese Americans .", "sentence_id": 8}
+{"abstract_id": "25684089", "label": "objective", "text": "To perform a randomized trial to determine whether there is cardiovascular disease ( CVD ) risk reduction from a plant-based ( PB ) , no-added-fat diet and the American Heart Association ( AHA ) diet in children .", "sentence_id": 0}
+{"abstract_id": "25684089", "label": "methods", "text": "A @-week ( April @ , @ to May @ , @ ) , prospective randomized trial was undertaken in a large , Midwestern hospital system 's predominantly middle class outpatient pediatric practices .", "sentence_id": 1}
+{"abstract_id": "25684089", "label": "methods", "text": "Thirty children ( @-@ years of age ) parent pairs with a last recorded child body mass index > @th percentile and child cholesterol > @ mg/dL were randomized to PB or AHA with weekly @-hour classes of nutrition education .", "sentence_id": 2}
+{"abstract_id": "25684089", "label": "results", "text": "Children on PB had @ and children on AHA had @ statistically significant ( P < @ ) beneficial changes from baseline ( mean decreases ) : body mass index z-score ( PB ) ( -@ ) , systolic blood pressure ( PB ) ( -@ mm Hg ) , total cholesterol ( PB ) ( -@ mg/dL ) , low-density lipoprotein ( PB ) ( -@ mg/dL ) , high-sensitivity C-reactive protein ( PB ) ( -@ mg/L ) , insulin ( PB ) ( -@ uU/mL ) , myeloperoxidase ( PB/AHA ) ( -@ / @ pmol/L ) , mid-arm circumference ( PB/AHA ) ( -@ / -@ cm ) , weight ( PB/AHA ) ( -@ / -@ kg ) , and waist circumference ( AHA ) ( -@ cm ) .", "sentence_id": 3}
+{"abstract_id": "25684089", "label": "results", "text": "Adults on PB and AHA had @ and @ , respectively , statistically significant ( P < @ ) beneficial changes .", "sentence_id": 4}
+{"abstract_id": "25684089", "label": "results", "text": "The significant change favoring AHA was a @ % difference in children 's waist circumference .", "sentence_id": 5}
+{"abstract_id": "25684089", "label": "results", "text": "Difficulty shopping for food for the PB was the only statistically significant acceptability barrier .", "sentence_id": 6}
+{"abstract_id": "25684089", "label": "conclusions", "text": "PB and the AHA in both children and adults demonstrated potentially beneficial changes from baseline in risk factors for CVD .", "sentence_id": 7}
+{"abstract_id": "25684089", "label": "conclusions", "text": "Future larger , long-term randomized trials with easily accessible PB foods will further define the role of the PB in preventing CVD .", "sentence_id": 8}
+{"abstract_id": "25863562", "label": "background", "text": "Vitamin D has immunomodulatory effects that might aid clearance of mycobacterial infection .", "sentence_id": 0}
+{"abstract_id": "25863562", "label": "background", "text": "We aimed to assess whether vitamin D supplementation would reduce time to sputum culture conversion in patients with active tuberculosis .", "sentence_id": 1}
+{"abstract_id": "25863562", "label": "methods", "text": "We did this randomised , double-blind , placebo-controlled , superiority trial at @ sites in India .", "sentence_id": 2}
+{"abstract_id": "25863562", "label": "methods", "text": "Treatment-naive patients who were sputum-smear positive , HIV negative , and had pulmonary tuberculosis were randomly assigned ( @:@ ) , with centrally labelled , serially numbered bottles , to receive standard active tuberculosis treatment with either supplemental high-dose oral vitamin D@ ( four doses of @ mg at weeks @ , @ , @ , and @ ) or placebo .", "sentence_id": 3}
+{"abstract_id": "25863562", "label": "methods", "text": "Neither the patients nor the clinical and laboratory investigators and personnel were aware of treatment assignment .", "sentence_id": 4}
+{"abstract_id": "25863562", "label": "methods", "text": "The primary efficacy outcome was time to sputum culture conversion .", "sentence_id": 5}
+{"abstract_id": "25863562", "label": "methods", "text": "Analysis was by modified intention to treat .", "sentence_id": 6}
+{"abstract_id": "25863562", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "25863562", "label": "results", "text": "Between Jan @ , @ , and Aug @ , @ , we randomly assigned @ participants to the vitamin D group ( n = @ ) or the placebo group ( n = @ ) , of whom @ participants ( n = @ and n = @ , respectively ) were included in the primary efficacy analysis .", "sentence_id": 8}
+{"abstract_id": "25863562", "label": "results", "text": "Median time to culture conversion in the vitamin D group was @ days ( @ % CI @-@ ) versus @ days ( @-@ ) in the placebo group ( log-rank p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25863562", "label": "results", "text": "Three ( @ % ) patients died in the vitamin D group and one ( @ % ) patient died in the placebo group ; no death was considered attributable to the study intervention .", "sentence_id": 10}
+{"abstract_id": "25863562", "label": "results", "text": "No patients had hypercalcaemia .", "sentence_id": 11}
+{"abstract_id": "25863562", "label": "conclusions", "text": "Our findings show that vitamin D supplementation did not reduce time to sputum culture conversion .", "sentence_id": 12}
+{"abstract_id": "25863562", "label": "conclusions", "text": "Further studies should investigate the role of vitamin D in prevention or reactivation of tuberculosis infection .", "sentence_id": 13}
+{"abstract_id": "25135743", "label": "background", "text": "To further assess the safety profile of the fixed-dose combination of indacaterol and glycopyrronium ( QVA@ ) and its monocomponents ; we investigated the impact of individual patient-level factors and time by integrating the patient-level safety data from the QVA@ clinical programme with relevant information from the independent indacaterol and glycopyrronium safety databases .", "sentence_id": 0}
+{"abstract_id": "25135743", "label": "methods", "text": "Data from @,@ patients with chronic obstructive pulmonary disease ( COPD ) were pooled from @ clinical studies of QVA@ , indacaterol and glycopyrronium of @ month 's duration with at least two of the treatment groups : QVA@ @/@g , glycopyrronium @g , indacaterol @g , placebo or tiotropium @g .", "sentence_id": 1}
+{"abstract_id": "25135743", "label": "methods", "text": "Overall hazard ratio ( HR ) was assessed between the active treatments and placebo and in various subgroups related to severity of airways obstruction , inhaled corticosteroid use , cardiovascular risk factors , sex , age and body mass index for death , serious cases of cardio - and cerebrovascular ( CCV ) events , major adverse cardiovascular events ( MACEs ) , pneumonia , COPD exacerbations requiring hospitalisation or atrial flutter/fibrillation ( AF/F ) .", "sentence_id": 2}
+{"abstract_id": "25135743", "label": "results", "text": "The HR for QVA@ versus placebo showed no significant increase in the overall risk for death ( HR -LSB- @ % confidence interval -RSB- : @ -LSB- @-@ @ -RSB- ) ; CCV events ( @ -LSB- @-@ @ -RSB- ) ; MACE ( @ -LSB- @-@ @ -RSB- ) ; pneumonia ( @ -LSB- @-@ @ -RSB- ) ; COPD exacerbations ( @ -LSB- @-@ @ -RSB- ) ; and AF/F ( @ -LSB- @-@ @ -RSB- ) .", "sentence_id": 3}
+{"abstract_id": "25135743", "label": "results", "text": "Similar results were observed for indacaterol , glycopyrronium and tiotropium versus placebo for overall risk and in analysed subgroups .", "sentence_id": 4}
+{"abstract_id": "25135743", "label": "conclusions", "text": "There was no increase in the risk for the investigated safety endpoints for the fixed-dose combination QVA@ , and it had a comparable safety profile as its monocomponents and tiotropium versus placebo .", "sentence_id": 5}
+{"abstract_id": "25444352", "label": "objective", "text": "To evaluate safety and effectiveness of the TECNIS toric intraocular lenses ( IOLs ) .", "sentence_id": 0}
+{"abstract_id": "25444352", "label": "methods", "text": "Prospective , multicenter , @-armed , bilateral , @-month clinical trial following the American National Standards Institute ( ANSI ) standard for Toric IOLs .", "sentence_id": 1}
+{"abstract_id": "25444352", "label": "methods", "text": "Subjects implanted with a TECNIS toric IOL ( n = @ ) or a TECNIS @-piece control IOL ( ZCB@ ; n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25444352", "label": "methods", "text": "Subjects underwent standard cataract surgery with IOL implantation .", "sentence_id": 3}
+{"abstract_id": "25444352", "label": "methods", "text": "The randomized control arm consisted of subjects requiring cylinder correction of @ to @ diopters ( D ) who were implanted with either toric ( ZCT@ ) or nontoric ( ZCB@ ) IOLs .", "sentence_id": 4}
+{"abstract_id": "25444352", "label": "methods", "text": "The open-label arm ( OLA ) consisted of subjects requiring cylinder correction of @ to @ D and implanted with ZCT@ , ZCT@ , or ZCT@ IOLs .", "sentence_id": 5}
+{"abstract_id": "25444352", "label": "methods", "text": "Assessments were at @ day , @ week , and @ , @ , and @ months and included uncorrected distance visual acuity ( UCDVA ) and best-corrected distance visual acuity ( BCDVA ) , manifest refraction , keratometry , adverse events , spectacle use , and photographic documentation of IOL rotational stability .", "sentence_id": 6}
+{"abstract_id": "25444352", "label": "results", "text": "Mean percent reduction in cylinder ( standard deviation ) was statistically significantly greater ( P < @ ) for ZCT@ eyes ( @ @ % ) versus ZCB@ eyes ( @ @ % ) .", "sentence_id": 7}
+{"abstract_id": "25444352", "label": "results", "text": "In the OLA , mean percent reduction in cylinder was @ @ % .", "sentence_id": 8}
+{"abstract_id": "25444352", "label": "results", "text": "A UCDVA of @/@ or better was achieved by @ % ( @/@ ) of ZCT@ eyes and by @ % ( @/@ ) of ZCB@ eyes ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25444352", "label": "results", "text": "In the OLA , @ % ( @/@ ) achieved @/@ or better UCDVA .", "sentence_id": 10}
+{"abstract_id": "25444352", "label": "results", "text": "Mean UCDVA was @ @ for ZCT@ eyes and @ @ for ZCB@ eyes ( P = @ ) ; in the OLA , mean UCDVA was @ @ .", "sentence_id": 11}
+{"abstract_id": "25444352", "label": "results", "text": "The BCDVA was @/@ or better for all eyes .", "sentence_id": 12}
+{"abstract_id": "25444352", "label": "results", "text": "Mean absolute lens rotation between visits for toric eyes pooled was less than @ .", "sentence_id": 13}
+{"abstract_id": "25444352", "label": "results", "text": "Lens rotation of @ or less occurred in @ % of toric eyes between @ and @ months and in @ % between @ and @ months , exceeding the ANSI standard for stability ( @ % of eyes with @ of rotation between visits ) .", "sentence_id": 14}
+{"abstract_id": "25444352", "label": "results", "text": "Four lenses ( @ % ) were repositioned during the study .", "sentence_id": 15}
+{"abstract_id": "25444352", "label": "conclusions", "text": "The TECNIS toric IOLs successfully reduce ocular astigmatism and are a safe and effective treatment for cataract patients with corneal astigmatism .", "sentence_id": 16}
+{"abstract_id": "25299536", "label": "objective", "text": "The purpose of this study was to determine whether whole-body vibration training could improve standing balance and muscle strength in children with Down syndrome .", "sentence_id": 0}
+{"abstract_id": "25299536", "label": "methods", "text": "This study was a randomized controlled trial studying @ children ( @-@ yrs old ) with Down syndrome .", "sentence_id": 1}
+{"abstract_id": "25299536", "label": "methods", "text": "They were assigned randomly using sealed envelopes , with @ children allocated to the control group ( @ boys , @ girls ) and another @ children allocated to the study group ( @ boys , @ girls ) .", "sentence_id": 2}
+{"abstract_id": "25299536", "label": "methods", "text": "The control group received a designed physical therapy program , whereas the study group received the same program given to the control group in addition to whole-body vibration training .", "sentence_id": 3}
+{"abstract_id": "25299536", "label": "methods", "text": "Both groups received the treatment sessions three times per week for @ successive months .", "sentence_id": 4}
+{"abstract_id": "25299536", "label": "methods", "text": "Measurement of stability indices by using the Biodex Stability System as well as muscle strength of the knee flexors and extensors by using a handheld dynamometer was done before and after the @ mos of the treatment program .", "sentence_id": 5}
+{"abstract_id": "25299536", "label": "results", "text": "Each group demonstrated significant improvements in stability indices and muscle strength after treatment ( P < @ ) , with significantly greater improvements seen in the study group when compared with the control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25299536", "label": "conclusions", "text": "Whole-body vibration may be a useful intervention modality to improve balance and muscle strength in children with Down syndrome .", "sentence_id": 7}
+{"abstract_id": "25707624", "label": "background", "text": "TAK-@ ( vonoprazan ) is a potassium-competitive acid blocker that reversibly inhibits gastric H ( + ) , K ( + ) - ATPase .", "sentence_id": 0}
+{"abstract_id": "25707624", "label": "objective", "text": "To evaluate the safety , tolerability , pharmacokinetics and pharmacodynamics of TAK-@ in healthy Japanese and non-Japanese men .", "sentence_id": 1}
+{"abstract_id": "25707624", "label": "methods", "text": "In two Phase I , randomised , double-blind , placebo-controlled studies , healthy men ( Japan N = @ ; UK N = @ ) received TAK-@ @-@mg once daily at a fixed dose level for @ consecutive days .", "sentence_id": 2}
+{"abstract_id": "25707624", "label": "methods", "text": "Assessments included safety , tolerability , pharmacokinetics and pharmacodynamics ( intragastric pH ) .", "sentence_id": 3}
+{"abstract_id": "25707624", "label": "results", "text": "Plasma concentration-time profiles of TAK-@ at all dose levels showed rapid absorption ( median Tmax @h ) .", "sentence_id": 4}
+{"abstract_id": "25707624", "label": "results", "text": "Mean elimination half-life was up to @h .", "sentence_id": 5}
+{"abstract_id": "25707624", "label": "results", "text": "Exposure was slightly greater than dose proportional , with no apparent time-dependent inhibition of metabolism .", "sentence_id": 6}
+{"abstract_id": "25707624", "label": "results", "text": "There was no important difference between the two studies in AUC@-tau on Day @ .", "sentence_id": 7}
+{"abstract_id": "25707624", "label": "results", "text": "TAK-@ caused dose-dependent acid suppression .", "sentence_id": 8}
+{"abstract_id": "25707624", "label": "results", "text": "On Day @ , mean @-h intragastric pH > @ holding time ratio ( HTR ) with @mg TAK-@ was @ % ( Japan ) and @ % ( UK ) , and mean night-time pH > @ HTR was @ % ( Japan ) and @ % ( UK ) .", "sentence_id": 9}
+{"abstract_id": "25707624", "label": "results", "text": "TAK-@ was well tolerated .", "sentence_id": 10}
+{"abstract_id": "25707624", "label": "results", "text": "The frequency of adverse events was similar at all dose levels and there were no serious adverse events .", "sentence_id": 11}
+{"abstract_id": "25707624", "label": "results", "text": "There were no important increases in serum alanine transaminase activity .", "sentence_id": 12}
+{"abstract_id": "25707624", "label": "results", "text": "Serum gastrin and pepsinogen I and II concentrations increased with TAK-@ dose .", "sentence_id": 13}
+{"abstract_id": "25707624", "label": "conclusions", "text": "TAK-@ in multiple rising oral dose levels of @-@mg once daily for @days was safe and well tolerated in healthy men and caused rapid , profound and sustained suppression of gastric acid secretion throughout each @-h dosing interval .", "sentence_id": 14}
+{"abstract_id": "25707624", "label": "conclusions", "text": "Clinicaltrials.gov identifiers : NCT@ and NCT@ .", "sentence_id": 15}
+{"abstract_id": "24236828", "label": "objective", "text": "PhaseIII DEFEND-@ investigated whether otelixizumab ( @ mg over @days ) preserved C-peptide secretion in patients with new-onset Type@ diabetes , focusing on adolescents ( @-@years ) .", "sentence_id": 0}
+{"abstract_id": "24236828", "label": "methods", "text": "One hundred and seventy-nine patients ( @ adolescents ) were randomized to otelixizumab or placebo .", "sentence_id": 1}
+{"abstract_id": "24236828", "label": "methods", "text": "The primary endpoint was change in @-h mixed-meal-stimulated C-peptide area under the curve at month@ .", "sentence_id": 2}
+{"abstract_id": "24236828", "label": "methods", "text": "Enrolment was suspended in April @ following negative efficacy results from DEFEND-@ .", "sentence_id": 3}
+{"abstract_id": "24236828", "label": "methods", "text": "DEFEND-@ terminated early after @months ' efficacy and safety follow-up .", "sentence_id": 4}
+{"abstract_id": "24236828", "label": "results", "text": "Change from baseline C-peptide was not significantly different -LSB- = -@ nmol/l ( @ % CI -@ to @ ; P = @ ) -RSB- .", "sentence_id": 5}
+{"abstract_id": "24236828", "label": "results", "text": "No differential C-peptide effect was seen for otelixizumab in adolescents and more adverse events were reported .", "sentence_id": 6}
+{"abstract_id": "24236828", "label": "conclusions", "text": "Efficacy and tolerability of otelixizumab was similar to DEFEND-@ .", "sentence_id": 7}
+{"abstract_id": "24236828", "label": "conclusions", "text": "The @-mg dose was non-efficacious in adults and adolescents .", "sentence_id": 8}
+{"abstract_id": "24236828", "label": "conclusions", "text": "Further investigation of the mechanism of action seen at higher doses and therapeutic window is required .", "sentence_id": 9}
+{"abstract_id": "24236828", "label": "conclusions", "text": "Clinical Trials Registry No : NCT@ .", "sentence_id": 10}
+{"abstract_id": "25027170", "label": "objective", "text": "Evaluation of the efficacy and toxicity of split-course accelerated hyperfractionated irradiation ( CHA-CHA ) as a sole treatment for advanced head and neck ( H&N ) cancer patients .", "sentence_id": 0}
+{"abstract_id": "25027170", "label": "methods", "text": "We enrolled @ patients ( @ in CHA-CHA and @ in conventional ( Conv . )", "sentence_id": 1}
+{"abstract_id": "25027170", "label": "methods", "text": "arm completed the treatment ) .", "sentence_id": 2}
+{"abstract_id": "25027170", "label": "methods", "text": "The CHA-CHA arm patients were irradiated twice a day , @ days a week , using a fraction dose ( fd ) of @ Gy up to @ Gy with an @-day gap in midterm .", "sentence_id": 3}
+{"abstract_id": "25027170", "label": "methods", "text": "Patients in the control ( Conv . )", "sentence_id": 4}
+{"abstract_id": "25027170", "label": "methods", "text": "arm group were irradiated with a fd of @ Gy , five times a week to a total dose of @-@ Gy in the overall treatment time of @-@ days .", "sentence_id": 5}
+{"abstract_id": "25027170", "label": "methods", "text": "Quality of life ( QOL ) and acute mucosal reaction were evaluated during radiotherapy ( RT ) .", "sentence_id": 6}
+{"abstract_id": "25027170", "label": "methods", "text": "After RT , we followed the effect of treatment , QOL , performance status and adverse effects of radiation .", "sentence_id": 7}
+{"abstract_id": "25027170", "label": "methods", "text": "For statistical analysis mainly a hierarchical multilevel modelling was used .", "sentence_id": 8}
+{"abstract_id": "25027170", "label": "results", "text": "QOL was most deteriorated in the CHA-CHA arm ; the CHA-CHA scheme also caused a relatively stronger acute injury .", "sentence_id": 9}
+{"abstract_id": "25027170", "label": "results", "text": "There were no significant differences in late adverse effects .", "sentence_id": 10}
+{"abstract_id": "25027170", "label": "results", "text": "In the CHA-CHA arm in @ % and in Conv .", "sentence_id": 11}
+{"abstract_id": "25027170", "label": "results", "text": "arm in @ % of patients , disease was controlled during follow-up .", "sentence_id": 12}
+{"abstract_id": "25027170", "label": "results", "text": "Tumour regression @ year after the treatment was significantly better in the CHA-CHA arm .", "sentence_id": 13}
+{"abstract_id": "25027170", "label": "results", "text": "However , the overall survival rate analysis did not show significant difference between both arms .", "sentence_id": 14}
+{"abstract_id": "25027170", "label": "conclusions", "text": "Despite differences in treatment results , we can not conclude that split-course accelerated hyperfractionated irradiation is superior to conventionally fractionated RT as a sole treatment for advanced H&N cancer patients .", "sentence_id": 15}
+{"abstract_id": "25027170", "label": "conclusions", "text": "Obtained results in the context of published data support the statement that altered fractionations alone do not give an advantage for advanced H&N cancer patients .", "sentence_id": 16}
+{"abstract_id": "25788234", "label": "background", "text": "The Placement of Aortic Transcatheter Valves ( PARTNER ) trial showed that mortality at @ year , @ years , and @ years is much the same with transcatheter aortic valve replacement ( TAVR ) or surgical aortic valve replacement ( SAVR ) for high-risk patients with aortic stenosis .", "sentence_id": 0}
+{"abstract_id": "25788234", "label": "background", "text": "We report here the @-year outcomes .", "sentence_id": 1}
+{"abstract_id": "25788234", "label": "methods", "text": "We did this randomised controlled trial at @ hospitals , in Canada ( two ) , Germany ( one ) , and the USA ( @ ) .", "sentence_id": 2}
+{"abstract_id": "25788234", "label": "methods", "text": "We used a computer-generated randomisation sequence to randomly assign high-risk patients with severe aortic stenosis to either SAVR or TAVR with a balloon-expandable bovine pericardial tissue valve by either a transfemoral or transapical approach .", "sentence_id": 3}
+{"abstract_id": "25788234", "label": "methods", "text": "Patients and their treating physicians were not masked to treatment allocation .", "sentence_id": 4}
+{"abstract_id": "25788234", "label": "methods", "text": "The primary outcome of the trial was all-cause mortality in the intention-to-treat population at @ year , we present here predefined outcomes at @ years .", "sentence_id": 5}
+{"abstract_id": "25788234", "label": "methods", "text": "The study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "25788234", "label": "results", "text": "We screened @ patients , of whom @ were enrolled ( @ assigned to TAVR , @ assigned to SAVR ) .", "sentence_id": 7}
+{"abstract_id": "25788234", "label": "results", "text": "Overall mean Society of Thoracic Surgeons Predicted Risk of Mortality score was @ % .", "sentence_id": 8}
+{"abstract_id": "25788234", "label": "results", "text": "At @ years , risk of death was @ % in the TAVR group compared with @ % in the SAVR group ( hazard ratio @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25788234", "label": "results", "text": "We recorded no structural valve deterioration requiring surgical valve replacement in either group .", "sentence_id": 10}
+{"abstract_id": "25788234", "label": "results", "text": "Moderate or severe aortic regurgitation occurred in @ ( @ % ) of @ patients in the TAVR group and two ( @ % ) of @ in the SAVR group ( p < @ ) , and was associated with increased @-year risk of mortality in the TAVR group ( @ % for moderate or severe aortic regurgitation vs @ % for those with mild aortic regurgitation or less ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25788234", "label": "conclusions", "text": "Our findings show that TAVR as an alternative to surgery for patients with high surgical risk results in similar clinical outcomes .", "sentence_id": 12}
+{"abstract_id": "24444659", "label": "background", "text": "Transthoracic echocardiographic ( TTE ) imaging is the mainstay of clinical practice for evaluating right ventricular ( RV ) size and function , but its accuracy in patients with pulmonary hypertension has not been well validated .", "sentence_id": 0}
+{"abstract_id": "24444659", "label": "methods", "text": "Magnetic resonance imaging ( MRI ) and TTE images were retrospectively reviewed in @ consecutive patients with pulmonary hypertension .", "sentence_id": 1}
+{"abstract_id": "24444659", "label": "methods", "text": "RV and left ventricular volumes and ejection fractions were calculated using MRI .", "sentence_id": 2}
+{"abstract_id": "24444659", "label": "methods", "text": "TTE areas and indices of RV ejection fraction ( RVEF ) were compared .", "sentence_id": 3}
+{"abstract_id": "24444659", "label": "results", "text": "The average age was @ @ years , with a majority of women ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "24444659", "label": "results", "text": "There was a wide range of mean pulmonary arterial pressures ( @-@ mm Hg ) and RV end-diastolic volumes ( @-@ mL ) , RVEFs ( @ % -@ % ) , and left ventricular ejection fractions ( @ % -@ % ) by MRI .", "sentence_id": 5}
+{"abstract_id": "24444659", "label": "results", "text": "There was a strong association between TTE and MRI-derived parameters : RV end-diastolic area ( by TTE imaging ) and RV end-diastolic volume ( by MRI ) , R ( @ ) = @ ( P < @ ) ; RV fractional area change by TTE imaging and RVEF by MRI , R ( @ ) = @ ( P < @ ) ; and tricuspid annular plane systolic excursion by TTE imaging and RVEF by MRI , R ( @ ) = @ ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24444659", "label": "results", "text": "By receiver operating characteristic curve analysis , an RV fractional area change < @ % provided excellent discrimination of moderate systolic dysfunction ( RVEF < @ % ) , with an area under the curve of @ ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24444659", "label": "results", "text": "An RV end-diastolic area index of @cm ( @ ) / m ( @ ) provided excellent discrimination for moderate RV enlargement ( area under the curve , @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24444659", "label": "conclusions", "text": "Echocardiographic estimates of RV volume ( by RV end-diastolic area ) and function ( by RV fractional area change and tricuspid annular plane systolic excursion ) offer good approximations of RV size and function in patients with pulmonary hypertension and allow the accurate discrimination of normal from abnormal .", "sentence_id": 9}
+{"abstract_id": "24799543", "label": "objective", "text": "Previous studies have focused on the effect of food advertisements on the caloric intake of children .", "sentence_id": 0}
+{"abstract_id": "24799543", "label": "objective", "text": "However , the role of individual susceptibility in this effect is unclear .", "sentence_id": 1}
+{"abstract_id": "24799543", "label": "objective", "text": "The aim of this study was to examine the role of impulsivity in the effect of advergames that promote energy-dense snacks on children 's snack intake .", "sentence_id": 2}
+{"abstract_id": "24799543", "label": "methods", "text": "First , impulsivity scores were assessed with a computer task .", "sentence_id": 3}
+{"abstract_id": "24799543", "label": "methods", "text": "Then a randomized between-subject design was conducted with @ children aged @ to @ years who played an advergame promoting either energy-dense snacks or nonfood products .", "sentence_id": 4}
+{"abstract_id": "24799543", "label": "methods", "text": "As an extra manipulation , half of the children in each condition were rewarded for refraining from eating , the other half were not .", "sentence_id": 5}
+{"abstract_id": "24799543", "label": "methods", "text": "Children could eat freely while playing the game .", "sentence_id": 6}
+{"abstract_id": "24799543", "label": "methods", "text": "Food intake was measured .", "sentence_id": 7}
+{"abstract_id": "24799543", "label": "methods", "text": "The children then completed questionnaire measures , and were weighed and measured .", "sentence_id": 8}
+{"abstract_id": "24799543", "label": "results", "text": "Overall , playing an advergame containing food cues increased general caloric intake .", "sentence_id": 9}
+{"abstract_id": "24799543", "label": "results", "text": "Furthermore , rewarding children to refrain from eating decreased their caloric intake .", "sentence_id": 10}
+{"abstract_id": "24799543", "label": "results", "text": "Finally , rewarding impulsive children to refrain from eating had no influence when they were playing an advergame promoting energy-dense snacks , whereas it did lead to reduced intake among low impulsive children and children who played nonfood advergames .", "sentence_id": 11}
+{"abstract_id": "24799543", "label": "conclusions", "text": "Playing an advergame promoting energy-dense snacks contributes to increased caloric intake in children .", "sentence_id": 12}
+{"abstract_id": "24799543", "label": "conclusions", "text": "The advergame promoting energy-dense snacks overruled the inhibition task to refrain from eating among impulsive children , making it more difficult for them to refrain from eating .", "sentence_id": 13}
+{"abstract_id": "24799543", "label": "conclusions", "text": "The findings suggest that impulsivity plays an important role in susceptibility to food advertisements .", "sentence_id": 14}
+{"abstract_id": "25011722", "label": "background", "text": "The EVEREST II ( Endovascular Valve Edge-to-Edge REpair STudy ) High-Risk registry and REALISM Continued Access Study High-Risk Arm are prospective registries of patients who received the MitraClip device ( Abbott Vascular , Santa Clara , California ) for mitral regurgitation ( MR ) in the United States .", "sentence_id": 0}
+{"abstract_id": "25011722", "label": "objective", "text": "The purpose of this study was to report @-month outcomes in high-risk patients treated with the percutaneous mitral valve edge-to-edge repair .", "sentence_id": 1}
+{"abstract_id": "25011722", "label": "methods", "text": "Patients with grades @ to @ + MR and a surgical mortality risk of @ % , based on the Society of Thoracic Surgeons risk calculator or the estimate of a surgeon coinvestigator following pre-specified protocol criteria , were enrolled .", "sentence_id": 2}
+{"abstract_id": "25011722", "label": "results", "text": "In the studies , @ of @ patients completed @ months of follow-up .", "sentence_id": 3}
+{"abstract_id": "25011722", "label": "results", "text": "Patients were elderly ( @ @ years of age ) , with @ % having functional MR and @ % having prior cardiac surgery .", "sentence_id": 4}
+{"abstract_id": "25011722", "label": "results", "text": "The mitral valve device reduced MR to @ + in @ % of patients at discharge ( n = @ ; p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25011722", "label": "results", "text": "Major adverse events at @ days included death in @ % , myocardial infarction in @ % , and stroke in @ % .", "sentence_id": 6}
+{"abstract_id": "25011722", "label": "results", "text": "At @ months , MR was @ + in @ % of patients ( n = @ ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25011722", "label": "results", "text": "From baseline to @ months , left ventricular ( LV ) end-diastolic volume improved from @ @ ml to @ @ ml ( n = @ ; p < @ ) and LV end-systolic volume improved from @ @ ml to @ @ ml ( n = @ ; p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25011722", "label": "results", "text": "New York Heart Association functional class improved from @ % in class III/IV at baseline to @ % in class I/II at @ months ( n = @ ; p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25011722", "label": "results", "text": "The @-item Short Form Health Survey physical and mental quality-of-life scores improved from baseline to @ months ( n = @ ; p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25011722", "label": "results", "text": "Annual hospitalization rate for heart failure fell from @ % pre-procedure to @ % post-procedure ( n = @ ; p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25011722", "label": "results", "text": "Kaplan-Meier survival estimate at @ months was @ % .", "sentence_id": 12}
+{"abstract_id": "25011722", "label": "conclusions", "text": "The percutaneous mitral valve device significantly reduced MR , improved clinical symptoms , and decreased LV dimensions at @ months in this high-surgical-risk cohort .", "sentence_id": 13}
+{"abstract_id": "25011722", "label": "conclusions", "text": "( Endovascular Valve Edge-to-Edge REpair STudy -LSB- EVERESTIIRCT -RSB- ; NCT@ ) .", "sentence_id": 14}
+{"abstract_id": "24828790", "label": "objective", "text": "The aim of this study was to compare health-related quality of life ( HRQoL ) scores obtained from the instrument Short Form ( SF ) -@ through the so-called SF-@D utilities , and those obtained from @D , in patients with ST-elevation myocardial infarction ( STEMI ) , and to evaluate the consequences in estimation of quality adjusted life years ( QALYs ) .", "sentence_id": 0}
+{"abstract_id": "24828790", "label": "methods", "text": "This was a sub-study of the Norwegian District Treatment of STEMI , in which patients with STEMI treated with tenecteplase , were randomized to early angioplasty or standard management ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24828790", "label": "methods", "text": "HRQoL data were collected at all visits ( @ , @ , @ , @ and @ months ) .", "sentence_id": 2}
+{"abstract_id": "24828790", "label": "methods", "text": "All patients with complete data were included ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24828790", "label": "results", "text": "The score range was @-@ @ for SF-@D and @-@ @ for @D .", "sentence_id": 4}
+{"abstract_id": "24828790", "label": "results", "text": "Mean utility scores from @D were higher and had different distribution compared to scores from SF-@D .", "sentence_id": 5}
+{"abstract_id": "24828790", "label": "results", "text": "Mean QALY for the whole group was higher using @D than SF-@D ( @ vs. @ ) .", "sentence_id": 6}
+{"abstract_id": "24828790", "label": "results", "text": "The incremental number of QALYs with early angioplasty compared to standard treatment was @ ( @ % CI : - @ to @ ) using SF-@D , and @ ( @ % CI : - @ to @ ) using the @D instrument .", "sentence_id": 7}
+{"abstract_id": "24828790", "label": "conclusions", "text": "Choice of instrument may influence HRQoL scores , but not necessarily the gain in QALYs .", "sentence_id": 8}
+{"abstract_id": "24315521", "label": "background", "text": "Post-thrombotic syndrome ( PTS ) is a common and burdensome complication of deep venous thrombosis ( DVT ) .", "sentence_id": 0}
+{"abstract_id": "24315521", "label": "background", "text": "Previous trials suggesting benefit of elastic compression stockings ( ECS ) to prevent PTS were small , single-centre studies without placebo control .", "sentence_id": 1}
+{"abstract_id": "24315521", "label": "background", "text": "We aimed to assess the efficacy of ECS , compared with placebo stockings , for the prevention of PTS .", "sentence_id": 2}
+{"abstract_id": "24315521", "label": "methods", "text": "We did a multicentre randomised placebo-controlled trial of active versus placebo ECS used for @ years to prevent PTS after a first proximal DVT in centres in Canada and the USA .", "sentence_id": 3}
+{"abstract_id": "24315521", "label": "methods", "text": "Patients were randomly assigned to study groups with a web-based randomisation system .", "sentence_id": 4}
+{"abstract_id": "24315521", "label": "methods", "text": "Patients presenting with a first symptomatic , proximal DVT were potentially eligible to participate .", "sentence_id": 5}
+{"abstract_id": "24315521", "label": "methods", "text": "They were excluded if the use of compression stockings was contraindicated , they had an expected lifespan of less than @ months , geographical inaccessibility precluded return for follow-up visits , they were unable to apply stockings , or they received thrombolytic therapy for the initial treatment of acute DVT .", "sentence_id": 6}
+{"abstract_id": "24315521", "label": "methods", "text": "The primary outcome was PTS diagnosed at @ months or later using Ginsberg 's criteria ( leg pain and swelling of @ month duration ) .", "sentence_id": 7}
+{"abstract_id": "24315521", "label": "methods", "text": "We used a modified intention to treat Cox regression analysis , supplemented by a prespecified per-protocol analysis of patients who reported frequent use of their allocated treatment .", "sentence_id": 8}
+{"abstract_id": "24315521", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ , and Current Controlled Trials , number ISRCTN@ .", "sentence_id": 9}
+{"abstract_id": "24315521", "label": "results", "text": "From @ to @ , @ patients were randomly assigned to receive active ECS and @ placebo ECS .", "sentence_id": 10}
+{"abstract_id": "24315521", "label": "results", "text": "The cumulative incidence of PTS was @ % in active ECS versus @ % in placebo ECS ( hazard ratio adjusted for centre @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24315521", "label": "results", "text": "Results were similar in a prespecified per-protocol analysis of patients who reported frequent use of stockings .", "sentence_id": 12}
+{"abstract_id": "24315521", "label": "conclusions", "text": "ECS did not prevent PTS after a first proximal DVT , hence our findings do not support routine wearing of ECS after DVT .", "sentence_id": 13}
+{"abstract_id": "25082573", "label": "background", "text": "The results of SYNTAX trial have been reported based on `` corelab '' calculated SS ( cSS ) .", "sentence_id": 0}
+{"abstract_id": "25082573", "label": "background", "text": "It has been shown that reproducibility of SS is better among the core laboratory technicians than interventional cardiologists .", "sentence_id": 1}
+{"abstract_id": "25082573", "label": "background", "text": "Thus , the prognostic value and clinical implication of the `` site '' SYNTAX SS ( sSS ) remain unknown .", "sentence_id": 2}
+{"abstract_id": "25082573", "label": "objective", "text": "The study sought to evaluate the prognostic value and clinical implication of the sSS after percutaneous coronary intervention ( PCI ) or coronary artery bypass graft ( CABG ) surgery in the randomized SYNTAX trial .", "sentence_id": 3}
+{"abstract_id": "25082573", "label": "methods", "text": "The sSS was calculated by the site investigators before randomization in the SYNTAX trial .", "sentence_id": 4}
+{"abstract_id": "25082573", "label": "methods", "text": "New tertiles based on the sSS were defined with low ( @ to @ ) , intermediate ( @ to @ ) , and high ( @ ) scores .", "sentence_id": 5}
+{"abstract_id": "25082573", "label": "methods", "text": "The clinical endpoints were compared between PCI and CABG by Kaplan-Meier estimates , log-rank comparison , and Cox regression analyses using the new tertiles .", "sentence_id": 6}
+{"abstract_id": "25082573", "label": "methods", "text": "The sSS-based SS II was calculated and its predictive performance was evaluated .", "sentence_id": 7}
+{"abstract_id": "25082573", "label": "results", "text": "The mean difference in cSS and sSS is @ @ , with a mean absolute difference of @ @ .", "sentence_id": 8}
+{"abstract_id": "25082573", "label": "results", "text": "In the overall cohort , using sSS there was a higher incidence of major adverse cardiac and cerebrovascular events ( MACCE ) at @-year follow-up in the PCI group for low ( @ % vs. @ % ; p = @ ) , intermediate ( @ % vs. @ % ; p = @ ) , and high ( @ % vs. @ % ; p = @ ) tertiles , compared with the CABG group .", "sentence_id": 9}
+{"abstract_id": "25082573", "label": "results", "text": "Similarly , in the @-vessel disease subgroup , @-year MACCE rates were higher in PCI group in all tertiles .", "sentence_id": 10}
+{"abstract_id": "25082573", "label": "results", "text": "Conversely , in the left main subgroup , MACCE rates were similar for PCI and CABG groups in all tertiles .", "sentence_id": 11}
+{"abstract_id": "25082573", "label": "results", "text": "The sSS-based SS II ( c-index : @ ) had predictive performance similar to the cSS-based SS II ( c-index : @ ) , with net reclassification index of -@ ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25082573", "label": "conclusions", "text": "Appropriate training and unbiased assessment are needed when using SS in clinical decision making .", "sentence_id": 13}
+{"abstract_id": "25082573", "label": "conclusions", "text": "sSS and tertiles based on sSS showed poor discrimination among low , intermediate , and high-risk groups .", "sentence_id": 14}
+{"abstract_id": "25082573", "label": "conclusions", "text": "However , combining clinical factors with sSS retained the predictive performance of SS II .", "sentence_id": 15}
+{"abstract_id": "25082573", "label": "conclusions", "text": "( SYNTAX Study : TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries ; NCT@ ) .", "sentence_id": 16}
+{"abstract_id": "24429541", "label": "background", "text": "Epidemiologic evidence has suggested that diets with a high ratio of palmitic acid ( PA ) to oleic acid ( OA ) increase risk of cardiovascular disease ( CVD ) .", "sentence_id": 0}
+{"abstract_id": "24429541", "label": "objective", "text": "To gain additional insights into the relative effect of dietary fatty acids and their metabolism on CVD risk , we sought to identify a metabolomic signature that tracks with diet-induced changes in blood lipid concentrations and whole-body fat oxidation .", "sentence_id": 1}
+{"abstract_id": "24429541", "label": "methods", "text": "We applied comprehensive metabolomic profiling tools to biological specimens collected from @ healthy adults enrolled in a crossover trial that compared a @-wk high-palmitic acid ( HPA ) with a low-palmitic acid and high-oleic acid ( HOA ) diet .", "sentence_id": 2}
+{"abstract_id": "24429541", "label": "results", "text": "A principal components analysis of the data set including @ variables measured in @ subjects in the fasted state identified one factor , the principal components analysis factor in the fasted state ( PCF@-Fasted ) , which was heavily weighted by the PA : OA ratio of serum and muscle lipids , that was affected by diet ( P < @ ; HPA greater than HOA ) .", "sentence_id": 3}
+{"abstract_id": "24429541", "label": "results", "text": "One other factor , the additional principal components analysis factor in the fasted state ( PCF@-Fasted ) , reflected a wide range of acylcarnitines and was affected by diet in women only ( P = @ ; HPA greater than HOA ) .", "sentence_id": 4}
+{"abstract_id": "24429541", "label": "results", "text": "HOA lowered the ratio of serum low-density lipoprotein to high-density lipoprotein ( LDL : HDL ) in men and women , and adjustment for the PCF@-Fasted abolished the effect .", "sentence_id": 5}
+{"abstract_id": "24429541", "label": "results", "text": "In women only , adjustment for the PCF@-Fasted eliminated the HOA-diet effect on serum total - and LDL-cholesterol concentrations .", "sentence_id": 6}
+{"abstract_id": "24429541", "label": "results", "text": "The respiratory exchange ratio in the fasted state was lower with the HPA diet ( P = @ ) , and the diet effect was eliminated after adjustment for the PCF@-Fasted .", "sentence_id": 7}
+{"abstract_id": "24429541", "label": "results", "text": "The messenger RNA expression of the cholesterol regulatory gene insulin-induced gene-@ was higher with the HOA diet ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24429541", "label": "conclusions", "text": "These results suggest that replacing dietary PA with OA reduces the blood LDL concentration and whole-body fat oxidation by modifying the saturation index of circulating and tissue lipids .", "sentence_id": 9}
+{"abstract_id": "24429541", "label": "conclusions", "text": "In women , these effects are also associated with a higher production and accumulation of acylcarnitines , possibly reflecting a shift in fat catabolism .", "sentence_id": 10}
+{"abstract_id": "24520784", "label": "objective", "text": "To observe the effect of qi benefiting stasis removing method ( QBSRM ) on systemic inflammatory response and coagulation function in multiple organ dysfunction syndrome ( MODS ) patients .", "sentence_id": 0}
+{"abstract_id": "24520784", "label": "methods", "text": "Totally @ MODS patients who were admitted to Affiliated Hospital of Nanjing University of Traditional Chinese Medicine between May @ to December @ were randomly assigned to two groups , the experimental group ( @ cases ) and the control group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24520784", "label": "methods", "text": "Patients in the control group were treated with routine Western therapy , while those in the experimental group additionally took decoction for benefiting qi removing stasis .", "sentence_id": 2}
+{"abstract_id": "24520784", "label": "methods", "text": "Inflammatory factors ( including interleukin-@ , interleukin-@ , tumor necrosis factor-alpha ) and coagulation parameters -LSB- including prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , and D-dimer ( DD ) -RSB- were observed before treatment , and @ , @ , and @ days after treatment in the two groups .", "sentence_id": 3}
+{"abstract_id": "24520784", "label": "results", "text": "At day @ after treatment , levels of interleukin-@ , interleukin-@ , and PT were significantly lower in the experimental group than in the control group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24520784", "label": "results", "text": "At day @ after treatment , tumor necrosis factor-x and DD were significantly lower in the experimental group than in the control group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24520784", "label": "results", "text": "There was no statistical difference in APTT or FIB at day @ , @ and @ after treatment ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24520784", "label": "conclusions", "text": "QBSRM could relieve systemic inflammatory response and improve coagulation functions .", "sentence_id": 7}
+{"abstract_id": "24766978", "label": "background", "text": "We previously found that the use of ezetimibe increased rapidly with different patterns between the United States ( US ) and Canada prior to the landmark Ezetimibe and Simvastatin in Hypercholesterolemia Enhance Atherosclerosis Regression ( ENHANCE ) trial , which was reported in January @ , and failed to show that the drug slowed the progression of atherosclerosis .", "sentence_id": 0}
+{"abstract_id": "24766978", "label": "background", "text": "What is not known is how practice in the @ countries changed after the ENHANCE trial .", "sentence_id": 1}
+{"abstract_id": "24766978", "label": "background", "text": "We examined ezetimibe use trends in the US and Canada before and after the reporting of the ENHANCE trial .", "sentence_id": 2}
+{"abstract_id": "24766978", "label": "methods", "text": "We conducted a population-based , retrospective , time-series analysis using the data collected by IMS Health in the US and CompuScript in Canada from January @ , @ , to December @ , @ .", "sentence_id": 3}
+{"abstract_id": "24766978", "label": "methods", "text": "The main outcome measure was monthly number of prescriptions for ezetimibe-containing products .", "sentence_id": 4}
+{"abstract_id": "24766978", "label": "results", "text": "The monthly number of ezetimibe prescriptions/@ ,@ population rose from @ to @,@ in the US from November @ to January @ , then significantly declined to @/@ ,@ population by December @ after the release of the ENHANCE trial , a decrease of @ % ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24766978", "label": "results", "text": "In contrast , in Canada , use continuously rose from @ to @/@ ,@ population from June @ to December @ ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24766978", "label": "results", "text": "United States expenditures totaled $ @ billion in @ .", "sentence_id": 7}
+{"abstract_id": "24766978", "label": "conclusions", "text": "Ezetimibe remains commonly used in both the US and Canada .", "sentence_id": 8}
+{"abstract_id": "24766978", "label": "conclusions", "text": "Ezetimibe use has decreased in the US post-ENHANCE , whereas use has gradually but steadily increased in Canada .", "sentence_id": 9}
+{"abstract_id": "24766978", "label": "conclusions", "text": "The diverging patterns of ezetimibe use in the US and Canada require further investigation , as they reveal that a common evidence base is eliciting very different utilization patterns in neighboring countries .", "sentence_id": 10}
+{"abstract_id": "25739317", "label": "objective", "text": "To compare mean heart and left anterior descending coronary artery ( LAD ) doses ( NTDmean ) and positional reproducibility in larger-breasted women receiving left breast radiotherapy using supine voluntary deep-inspiratory breath-hold ( VBH ) and free-breathing prone techniques .", "sentence_id": 0}
+{"abstract_id": "25739317", "label": "methods", "text": "Following surgery for early breast cancer , patients with estimated breast volumes > @ cm ( @ ) underwent planning-CT scans in supine VBH and free-breathing prone positions .", "sentence_id": 1}
+{"abstract_id": "25739317", "label": "methods", "text": "Radiotherapy treatment plans were prepared , and mean heart and LAD doses were calculated .", "sentence_id": 2}
+{"abstract_id": "25739317", "label": "methods", "text": "Patients were randomised to receive one technique for fractions @-@ , before switching techniques for fractions @-@ ( @ Gy/@ fractions total ) .", "sentence_id": 3}
+{"abstract_id": "25739317", "label": "methods", "text": "Daily electronic portal imaging and alternate-day cone-beam CT ( CBCT ) imaging were performed .", "sentence_id": 4}
+{"abstract_id": "25739317", "label": "methods", "text": "The primary endpoint was the difference in mean LAD NTDmean between techniques .", "sentence_id": 5}
+{"abstract_id": "25739317", "label": "methods", "text": "Population systematic ( ) and random errors ( ) were estimated .", "sentence_id": 6}
+{"abstract_id": "25739317", "label": "methods", "text": "Within-patient comparisons between techniques used Wilcoxon signed-rank tests .", "sentence_id": 7}
+{"abstract_id": "25739317", "label": "results", "text": "@ patients were recruited , with complete dosimetric data available for @ .", "sentence_id": 8}
+{"abstract_id": "25739317", "label": "results", "text": "Mean heart and LAD NTDmean doses for VBH and prone treatments respectively were @ and @ ( p < @ ) and @ and @ ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25739317", "label": "results", "text": "Clip-based CBCT errors for VBH and prone respectively were @ mm and @ mm ( ) and @ mm and @ mm ( ) .", "sentence_id": 10}
+{"abstract_id": "25739317", "label": "conclusions", "text": "In larger-breasted women , supine VBH provided superior cardiac sparing and reproducibility than a free-breathing prone position .", "sentence_id": 11}
+{"abstract_id": "25710923", "label": "objective", "text": "Depression is common in diabetes and linked to adverse health outcomes .", "sentence_id": 0}
+{"abstract_id": "25710923", "label": "objective", "text": "This study evaluated the efficacy of a guided web-based intervention in reducing depression in adults with type @ and type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "25710923", "label": "methods", "text": "A total of @ participants with diabetes and elevated depressive symptoms ( Center for Epidemiologic Studies Depression Scale -LSB- CES-D @ -RSB- ) were randomly assigned to the GET.ON Mood Enhancer Diabetes ( a guided self-help intervention , n = @ ) or a brief online unguided psychoeducation program for depression ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25710923", "label": "methods", "text": "The primary outcome was depressive symptoms severity ( CES-D ) .", "sentence_id": 3}
+{"abstract_id": "25710923", "label": "methods", "text": "The secondary outcomes included diabetes-specific emotional distress ( Problem Areas in Diabetes -LSB- PAID -RSB- scale ) and participant satisfaction ( adaption CSQ-@ ) .", "sentence_id": 4}
+{"abstract_id": "25710923", "label": "methods", "text": "Data were collected at baseline and @ months after randomization .", "sentence_id": 5}
+{"abstract_id": "25710923", "label": "methods", "text": "To identify differences in outcome between the groups , we used analyses of covariance with the baseline CES-D score as covariate on both intent-to-treat ( ITT ) and per-protocol ( PP ) basis .", "sentence_id": 6}
+{"abstract_id": "25710923", "label": "results", "text": "Compared with the control group , the intervention group showed significantly less depressive symptom severity at posttreatment based on ITT ( d = @ ) and PP analyses ( d = @ ) .", "sentence_id": 7}
+{"abstract_id": "25710923", "label": "results", "text": "The intervention participants displayed a significantly larger reduction in diabetes-specific emotional distress ( d = @ , ITT ) .", "sentence_id": 8}
+{"abstract_id": "25710923", "label": "results", "text": "The intervention appeared to be acceptable to the participants ; @ % ( n = @ ) would recommend the training to a friend with diabetes in need of psychological help .", "sentence_id": 9}
+{"abstract_id": "25710923", "label": "conclusions", "text": "A guided , web-based intervention to reduce depression in adults with type @ and type @ diabetes is effective in reducing both depressive symptoms and diabetes-specific emotional distress .", "sentence_id": 10}
+{"abstract_id": "24284498", "label": "background", "text": "Dietary sodium influences intermediate physiological traits in healthy adults independent of changes in blood pressure .", "sentence_id": 0}
+{"abstract_id": "24284498", "label": "background", "text": "The purpose of this study was to test the hypothesis that dietary sodium affects cardiac autonomic modulation during mental stress .", "sentence_id": 1}
+{"abstract_id": "24284498", "label": "methods", "text": "In a prospective , randomized cross-over design separated by @ month between diets , @ normotensive healthy young adults ( F/M : @/@ , aged @-@ years ) consumed a @-day low ( @ mmol/day ) , normal ( @ mmol ) , and high ( @ mmol ) sodium diet followed by heart rate variability ( HRV ) recordings at rest and during @-min computerized mental arithmetic .", "sentence_id": 2}
+{"abstract_id": "24284498", "label": "methods", "text": "Women were studied in the low hormone phase of the menstrual cycle following each diet .", "sentence_id": 3}
+{"abstract_id": "24284498", "label": "results", "text": "Diet did not affect resting blood pressure , but heart rate ( HR ) ( mean SE ) was @ @ , @ @ , and @ @ bpm in low , normal , and high sodium conditions , respectively ( analysis of variance P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24284498", "label": "results", "text": "For HRV , there was a main effect of sodium on resting SD of normalized RR intervals ( SDNN ) , square root of the mean squared difference of successive normalized RR intervals ( RMSSD ) , high frequency , low-frequency normalized units ( LFnu ) , and high-frequency normalized units ( HFnu ) ( P < @ for all ) .", "sentence_id": 5}
+{"abstract_id": "24284498", "label": "results", "text": "The response to low sodium was most marked and consistent with sympathetic activation and reduced vagal activity , with increased LFnu and decreased SDNN , RMSSD , and HFnu compared to both normal and high sodium conditions ( P @ for all ) .", "sentence_id": 6}
+{"abstract_id": "24284498", "label": "results", "text": "Dietary sodium-by-mental stress interactions were significant for mean NN , RMSSD , high-frequency power , LFnu , and low frequency/high frequency ratio ( P < @ for all ) .", "sentence_id": 7}
+{"abstract_id": "24284498", "label": "results", "text": "The interactions signify that sodium restriction evoked an increase in resting sympathetic activity and reduced vagal activity to the extent that mental stress caused modest additional disruptions in autonomic balance .", "sentence_id": 8}
+{"abstract_id": "24284498", "label": "results", "text": "Conversely , normal and high sodium evoked a reduction in resting sympathetic activity and incremental increase in resting vagal activity , which were disrupted to a greater extent during mental stress compared to low sodium .", "sentence_id": 9}
+{"abstract_id": "24284498", "label": "conclusions", "text": "We conclude that autonomic control of HRV at rest and during mental stress is altered by dietary sodium in healthy normotensive young adult men and women .", "sentence_id": 10}
+{"abstract_id": "24942975", "label": "background", "text": "Beta-palmitate ( sn-@ palmitate ) mimics human milk fat , enabling easier digestion.Therefore , we hypothesized that infants consuming high beta-palmitate formula would have more frequent , softer stools and reduced crying compared to infants consuming low beta-palmitate formula .", "sentence_id": 0}
+{"abstract_id": "24942975", "label": "methods", "text": "Formula-fed infants were randomly assigned to receive either ( @ ) formula with high beta-palmitate ( HBP , n = @ ) or ( @ ) regular formula with a standard vegetable oil mix ( LBP , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24942975", "label": "methods", "text": "A matched group of breastfed infants served as a reference ( BF , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24942975", "label": "methods", "text": "Crying and stool characteristics data were recorded by the parents for @ days before the @ - and @-week visits .", "sentence_id": 3}
+{"abstract_id": "24942975", "label": "results", "text": "We found no significant differences in the stool frequency or consistency between the two formula groups .", "sentence_id": 4}
+{"abstract_id": "24942975", "label": "results", "text": "The percentage of crying infants in the LBP group was significantly higher than that in the HBP and BF groups during the evening at @ weeks ( @ % vs. @ % and @ % , p < @ ) and during the afternoon at @ weeks ( @ % vs. @ % and @ % , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24942975", "label": "results", "text": "The infants fed HBP had significantly shorter crying durations when compared with infants fed LBP formula ( @ @ vs. @ @ min/day , respectively ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24942975", "label": "conclusions", "text": "Our study indicates that consumption of a high beta-palmitate formula affects infant crying patterns during the first weeks of life .", "sentence_id": 7}
+{"abstract_id": "24942975", "label": "conclusions", "text": "Comparable to breastfeeding , it reduced crying duration and frequency , primarily during the afternoon and evening hours , thereby improving the well-being of formula-fed infants and their parents .", "sentence_id": 8}
+{"abstract_id": "25358221", "label": "background", "text": "Acne vulgaris is a common inflammatory disorder of the skin that involves pilosebaceous units .", "sentence_id": 0}
+{"abstract_id": "25358221", "label": "background", "text": "This study was conducted to compare the efficacy of oral azithromycin with oral doxycycline in the treatment of acne vulgaris in our population .", "sentence_id": 1}
+{"abstract_id": "25358221", "label": "methods", "text": "This randomized controlled trial was conducted in the dermatology department of Lady Reading Hospital , Peshawar from January to December @ .", "sentence_id": 2}
+{"abstract_id": "25358221", "label": "methods", "text": "All male and female patients of age ( @-@ years ) having moderate acne vulgaris on face only were included in the study .", "sentence_id": 3}
+{"abstract_id": "25358221", "label": "methods", "text": "Patients were randomly divided into two groups .", "sentence_id": 4}
+{"abstract_id": "25358221", "label": "methods", "text": "Patients in first group were given azithromycin @ mg daily before meal for @ consecutive days monthly for @ months while patients in second group were given doxycycline @ mg daily after meals for @ months .", "sentence_id": 5}
+{"abstract_id": "25358221", "label": "methods", "text": "Patients were followed up after taking treatment for three months to see the response of each drug .", "sentence_id": 6}
+{"abstract_id": "25358221", "label": "methods", "text": "Response was graded as excellent , good , moderate , mild and no response .", "sentence_id": 7}
+{"abstract_id": "25358221", "label": "results", "text": "A total of @ patients equally divided in azithromycin and doxycycline groups .", "sentence_id": 8}
+{"abstract_id": "25358221", "label": "results", "text": "Male to female ratio in azithromycin and doxycycline groups was @:@ and @:@ respectively .", "sentence_id": 9}
+{"abstract_id": "25358221", "label": "results", "text": "Mean age in both groups was @ @ years and @ @ years respectively .", "sentence_id": 10}
+{"abstract_id": "25358221", "label": "results", "text": "In azithromycin group , an excellent response was noted in @ ( @ % ) , and good response was observed in @ ( @ % ) patients .", "sentence_id": 11}
+{"abstract_id": "25358221", "label": "results", "text": "In doxycycline group @ ( @ % ) patients had excellent and @ ( @ % ) patients had good response .", "sentence_id": 12}
+{"abstract_id": "25358221", "label": "results", "text": "The difference being statistically significant .", "sentence_id": 13}
+{"abstract_id": "25358221", "label": "conclusions", "text": "Doxycycline is a better option fdr treatment of acne vulgaris as compared to azithromycin .", "sentence_id": 14}
+{"abstract_id": "24415509", "label": "objective", "text": "Residents often teach medical students , other residents , and patients .", "sentence_id": 0}
+{"abstract_id": "24415509", "label": "objective", "text": "However , few residents get feedback about their teaching .", "sentence_id": 1}
+{"abstract_id": "24415509", "label": "objective", "text": "This study 's objective was to determine if feedback from medical students increases resident teaching identity .", "sentence_id": 2}
+{"abstract_id": "24415509", "label": "methods", "text": "This was a stratified , single blinded , randomized controlled trial of an educational intervention .", "sentence_id": 3}
+{"abstract_id": "24415509", "label": "methods", "text": "Residents were stratified based on year of residency and then randomized to receive feedback by medical students or not .", "sentence_id": 4}
+{"abstract_id": "24415509", "label": "methods", "text": "Medical students evaluated resident teaching effectiveness by ranking resident ability to apply the five microskills for clinical teaching and to role model being an effective clinician .", "sentence_id": 5}
+{"abstract_id": "24415509", "label": "methods", "text": "Residents were surveyed to determine their level of teacher identity before and after the intervention .", "sentence_id": 6}
+{"abstract_id": "24415509", "label": "methods", "text": "Allocation concealment and intention to treat principles were used .", "sentence_id": 7}
+{"abstract_id": "24415509", "label": "results", "text": "All residents ( n = @ ) that met inclusion criteria participated with complete response rate to both pre-intervention and post-intervention surveys .", "sentence_id": 8}
+{"abstract_id": "24415509", "label": "results", "text": "There was no difference in teaching identity between residents who received feedback and those who did not , except in one subscale of the Teacher Identity Scale-global teaching identity , where residents who received medical student feedback scored lower .", "sentence_id": 9}
+{"abstract_id": "24415509", "label": "conclusions", "text": "There was no difference between intervention and control group in resident teaching identity over time .", "sentence_id": 10}
+{"abstract_id": "24415509", "label": "conclusions", "text": "The residents found feedback important .", "sentence_id": 11}
+{"abstract_id": "24415509", "label": "conclusions", "text": "This was a randomized controlled trial with strong methodology that helps advance understanding of the importance of medical student feedback on resident teaching .", "sentence_id": 12}
+{"abstract_id": "24507091", "label": "background", "text": "No available treatments slow or halt progression of multiple system atrophy , which is a rare , progressive , fatal neurological disorder .", "sentence_id": 0}
+{"abstract_id": "24507091", "label": "background", "text": "In a mouse model of multiple system atrophy , rifampicin inhibited formation of - synuclein fibrils , the neuropathological hallmark of the disease .", "sentence_id": 1}
+{"abstract_id": "24507091", "label": "background", "text": "We aimed to assess the safety and efficacy of rifampicin in patients with multiple system atrophy .", "sentence_id": 2}
+{"abstract_id": "24507091", "label": "methods", "text": "In this randomised , double-blind , placebo-controlled trial we recruited participants aged @-@ years with possible or probable multiple system atrophy from ten US medical centres .", "sentence_id": 3}
+{"abstract_id": "24507091", "label": "methods", "text": "Eligible participants were randomly assigned ( @:@ ) via computer-generated permuted block randomisation to rifampicin @ mg twice daily or matching placebo ( @ mg riboflavin capsules ) , stratified by subtype ( parkinsonian vs cerebellar ) , with a block size of four .", "sentence_id": 4}
+{"abstract_id": "24507091", "label": "methods", "text": "The primary outcome was rate of change ( slope analysis ) from baseline to @ months in Unified Multiple System Atrophy Rating Scale ( UMSARS ) I score , analysed in all participants with at least one post-baseline measurement .", "sentence_id": 5}
+{"abstract_id": "24507091", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "24507091", "label": "results", "text": "Between April @ , @ , and April @ , @ , we randomly assigned @ participants ( @ to rifampicin and @ to placebo ) .", "sentence_id": 7}
+{"abstract_id": "24507091", "label": "results", "text": "Four participants in the rifampicin group and five in the placebo group withdrew from study prematurely .", "sentence_id": 8}
+{"abstract_id": "24507091", "label": "results", "text": "Results of the preplanned interim analysis ( n = @ in each group ) of the primary endpoint showed that futility criteria had been met , and the trial was stopped ( the mean rate of change -LSB- slope analysis -RSB- of UMSARS I score was @ points -LSB- SD @ -RSB- per month in the rifampicin group vs @ points -LSB- @ -RSB- per month in the placebo group ; futility p = @ ; efficacy p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24507091", "label": "results", "text": "At the time of study termination , @ participants in the rifampicin group and @ in the placebo group had follow-up data and were included in the final analysis .", "sentence_id": 10}
+{"abstract_id": "24507091", "label": "results", "text": "The primary endpoint was @ points ( SD @ ) per month for rifampicin and @ points ( @ ) per month for placebo ( difference @ , @ % CI -@ to @ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24507091", "label": "results", "text": "Three ( @ % ) of @ participants in the rifampicin group and @ ( @ % ) of @ in the placebo group had one or more serious adverse events ; none was thought to be related to treatment .", "sentence_id": 12}
+{"abstract_id": "24507091", "label": "conclusions", "text": "Our results show that rifampicin does not slow or halt progression of multiple system atrophy .", "sentence_id": 13}
+{"abstract_id": "24507091", "label": "conclusions", "text": "Despite the negative result , the trial does provide information that could be useful in the design of future studies assessing potential disease modifying therapies in patients with multiple system atrophy .", "sentence_id": 14}
+{"abstract_id": "25086490", "label": "background", "text": "There is no consensus on what type of arthroplasty is best for the treatment of complex proximal humeral fractures in elderly patients .", "sentence_id": 0}
+{"abstract_id": "25086490", "label": "background", "text": "The purpose of this prospective study was to compare the outcomes of reverse shoulder arthroplasty ( RSA ) and hemiarthroplasty ( HA ) .", "sentence_id": 1}
+{"abstract_id": "25086490", "label": "methods", "text": "Sixty-two patients older than @ years were randomized to RSA ( @ patients ) and HA ( @ patients ) .", "sentence_id": 2}
+{"abstract_id": "25086490", "label": "methods", "text": "One HA patient died at @ year , and she was excluded .", "sentence_id": 3}
+{"abstract_id": "25086490", "label": "methods", "text": "The mean follow-up was @ months ( range , @-@ months ) .", "sentence_id": 4}
+{"abstract_id": "25086490", "label": "results", "text": "Compared with HA patients , RSA patients had significantly higher ( P = @ ) mean University of California-Los Angeles ( @ vs @ ) and Constant ( @ vs @ ) scores , forward elevation ( @ vs @ ) , and abduction ( @ vs @ ) but no difference in internal rotation ( @ vs @ ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25086490", "label": "results", "text": "The Disabilities of the Arm , Shoulder , and Hand score was higher in the HA patients ( @ vs @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25086490", "label": "results", "text": "In the HA group , @ % of tuberosities healed and @ % resorbed .", "sentence_id": 7}
+{"abstract_id": "25086490", "label": "results", "text": "Patients with failure of tuberosities had significantly worse functional outcomes .", "sentence_id": 8}
+{"abstract_id": "25086490", "label": "results", "text": "There were @ complications ( intraoperative humeral fracture and superficial infection ) .", "sentence_id": 9}
+{"abstract_id": "25086490", "label": "results", "text": "One patient was manipulated under general anesthesia because of postoperative stiffness .", "sentence_id": 10}
+{"abstract_id": "25086490", "label": "results", "text": "Six patients with HA had proximal migration that required revision to RSA .", "sentence_id": 11}
+{"abstract_id": "25086490", "label": "results", "text": "In the RSA group , @ % of tuberosities healed and @ % resorbed .", "sentence_id": 12}
+{"abstract_id": "25086490", "label": "results", "text": "Functional outcome was irrespective of healing of the tuberosities .", "sentence_id": 13}
+{"abstract_id": "25086490", "label": "results", "text": "Notching was observed in only @ RSA patient .", "sentence_id": 14}
+{"abstract_id": "25086490", "label": "results", "text": "One patient developed a hematoma and another a deep infection requiring a @-stage revision to another RSA .", "sentence_id": 15}
+{"abstract_id": "25086490", "label": "conclusions", "text": "RSA resulted in better pain and function and lower revision rate .", "sentence_id": 16}
+{"abstract_id": "25086490", "label": "conclusions", "text": "Revision from HA to RSA does not appear to improve outcomes .", "sentence_id": 17}
+{"abstract_id": "24313693", "label": "objective", "text": "This study examined the feasibility of a prototype Web-based acceptance and commitment therapy ( ACT ) program for preventing mental health problems among college students .", "sentence_id": 0}
+{"abstract_id": "24313693", "label": "methods", "text": "Undergraduate first-year students ( N = @ ) participated between May and November @ .", "sentence_id": 1}
+{"abstract_id": "24313693", "label": "methods", "text": "Participants were randomized to ACT or a waitlist , with assessments conducted at baseline , posttherapy , and @-week follow-up .", "sentence_id": 2}
+{"abstract_id": "24313693", "label": "methods", "text": "Waitlist participants accessed the program after the second assessment .", "sentence_id": 3}
+{"abstract_id": "24313693", "label": "results", "text": "Program usability/usage data indicated high program acceptability .", "sentence_id": 4}
+{"abstract_id": "24313693", "label": "results", "text": "Significant improvements were found for ACT knowledge , education values , and depression with ACT relative to waitlist .", "sentence_id": 5}
+{"abstract_id": "24313693", "label": "results", "text": "Subgroup analyses indicated that ACT decreased depression and anxiety relative to waitlist among students with at least minimal distress .", "sentence_id": 6}
+{"abstract_id": "24313693", "label": "results", "text": "Within the ACT condition , significant improvements were observed from baseline to @-week follow-up on all outcome and process measures .", "sentence_id": 7}
+{"abstract_id": "24313693", "label": "conclusions", "text": "Results provide preliminary support for the feasibility of a Web-based ACT prevention program .", "sentence_id": 8}
+{"abstract_id": "26074397", "label": "objective", "text": "Breast International Group ( BIG ) @-@ is a randomised phase III trial that tested the effect of adding docetaxel , either in sequence to or in combination with anthracycline-based adjuvant chemotherapy , in women with node-positive breast cancer ( BC ) .", "sentence_id": 0}
+{"abstract_id": "26074397", "label": "objective", "text": "Here , we present the @-year final trial safety and efficacy analyses .", "sentence_id": 1}
+{"abstract_id": "26074397", "label": "objective", "text": "We also report an exploratory analysis on the predictive value of Ki@ for docetaxel efficacy , in the BIG @-@ and using a pooled analysis of three other randomised trials .", "sentence_id": 2}
+{"abstract_id": "26074397", "label": "methods", "text": "@ patients were randomly assigned in a @ trial design to one of four treatments .", "sentence_id": 3}
+{"abstract_id": "26074397", "label": "methods", "text": "The primary objective was to evaluate the overall efficacy of docetaxel on disease free survival ( DFS ) .", "sentence_id": 4}
+{"abstract_id": "26074397", "label": "methods", "text": "Secondary objectives included comparisons of sequential docetaxel versus sequential control arm , safety and overall survival ( OS ) .", "sentence_id": 5}
+{"abstract_id": "26074397", "label": "methods", "text": "Ki@ expression was centrally evaluated by immunohistochemistry .", "sentence_id": 6}
+{"abstract_id": "26074397", "label": "results", "text": "After a median follow-up of @ years , the addition of docetaxel did not significantly improve DFS or OS ( hazard ratio ( HR ) = @ , @ % confidence interval ( CI ) = @-@ @ ; P = @ and HR = @ , @ % CI = @-@ @ ; P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "26074397", "label": "results", "text": "Sequential docetaxel did not improve DFS compared to the sequential control arm ( HR = @ , @ % CI = @-@ @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26074397", "label": "results", "text": "In oestrogen receptor ( ER ) - positive tumours with Ki@ % , the addition of docetaxel resulted in @ % improvement in @-year OS ( P = @ , test for interaction = @ ) .", "sentence_id": 9}
+{"abstract_id": "26074397", "label": "results", "text": "In a multivariate model , there was a trend for improved DFS and OS in ER-positive patients with high Ki@ and treated with docetaxel ( HR = @ , @ % CI = @-@ @ ; P = @ and HR = @ , @ % CI = @-@ @ ; P = @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "26074397", "label": "results", "text": "A pooled analysis of four randomised trials showed a benefit of taxanes in highly proliferative ER-positive disease but not in low proliferating tumours ( interaction test P = @ ) .", "sentence_id": 11}
+{"abstract_id": "26074397", "label": "conclusions", "text": "The DFS benefit previously demonstrated with sequential docetaxel is no longer observed at @years .", "sentence_id": 12}
+{"abstract_id": "26074397", "label": "conclusions", "text": "However , an exploratory analysis suggested a benefit of docetaxel in patients with highly proliferative ER-positive BC .", "sentence_id": 13}
+{"abstract_id": "25298352", "label": "objective", "text": "A wide range of herbal plants have been reported to treat various gynecological problems of women .", "sentence_id": 0}
+{"abstract_id": "25298352", "label": "objective", "text": "This study was set out to investigate the effect of ginger ( Zingiber officinale ) on heavy menstrual bleeding ( HMB ) in high school girls .", "sentence_id": 1}
+{"abstract_id": "25298352", "label": "methods", "text": "Ninety-two young women who experienced HMB and met the inclusion criteria were recruited in this study .", "sentence_id": 2}
+{"abstract_id": "25298352", "label": "methods", "text": "Participants were evaluated for six consecutive menstrual cycles .", "sentence_id": 3}
+{"abstract_id": "25298352", "label": "methods", "text": "During @ assessment cycles , their HMB was confirmed by Pictorial Blood Assessment Chart .", "sentence_id": 4}
+{"abstract_id": "25298352", "label": "methods", "text": "They were then randomly allocated to two study groups to receive either ginger or placebo capsules .", "sentence_id": 5}
+{"abstract_id": "25298352", "label": "methods", "text": "The participants filled in the same chart during three intervention cycles .", "sentence_id": 6}
+{"abstract_id": "25298352", "label": "results", "text": "The level of menstrual blood loss dramatically declined during the three intervention cycles in ginger-receiving group .", "sentence_id": 7}
+{"abstract_id": "25298352", "label": "results", "text": "The decrease of blood loss in ginger-receiving group was significantly more remarkable than that of participants receiving placebo ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25298352", "label": "results", "text": "Minimum number of participants reported adverse effects .", "sentence_id": 9}
+{"abstract_id": "25298352", "label": "conclusions", "text": "HMB is highly prevalent among young women .", "sentence_id": 10}
+{"abstract_id": "25298352", "label": "conclusions", "text": "Considering the significance of appropriate and timely treatment and also the importance of prevention of unwanted consequences , ginger may be considered as an effective therapeutic option for HMB .", "sentence_id": 11}
+{"abstract_id": "24612414", "label": "background", "text": "Early oral feeding ( EOF ) following colorectal surgery can accelerate patient recovery and shorten hospital stay .", "sentence_id": 0}
+{"abstract_id": "24612414", "label": "background", "text": "However , some patients are intolerable to postoperative early oral feeding .", "sentence_id": 1}
+{"abstract_id": "24612414", "label": "background", "text": "The aim of this study was to evaluate the tolerability of EOF following laparoscopic colorectal cancer surgery and the effects of intravenous lidocaine .", "sentence_id": 2}
+{"abstract_id": "24612414", "label": "methods", "text": "The cohort in this randomized , placebo-controlled trial ( ClinicalTrial.gov , NCT@ ) comprised of @ patients undergoing elective laparoscopic colorectal cancer surgery .", "sentence_id": 3}
+{"abstract_id": "24612414", "label": "methods", "text": "For patients randomized to the lidocaine group , a loading dose of @mg/kg lidocaine prior to skin incision , and a continuous dose of @mg/kg/h lidocaine with @mg ketorolac ( non-steroidal anti-inflammatory drug ) ( in normal saline , total @mL ) was administered for @h .", "sentence_id": 4}
+{"abstract_id": "24612414", "label": "methods", "text": "Patients randomized to the placebo group received a loading dose of @mL saline and a continuous dose of @mg ketorolac in @mL saline .", "sentence_id": 5}
+{"abstract_id": "24612414", "label": "methods", "text": "The primary outcome measure was prevalence of postoperative nausea/vomiting and intolerance to EOF .", "sentence_id": 6}
+{"abstract_id": "24612414", "label": "results", "text": "Altogether , @ patients completed the study and were analyzed .", "sentence_id": 7}
+{"abstract_id": "24612414", "label": "results", "text": "Postoperative nausea and vomiting were higher in the control group but did not reach statistical significance ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24612414", "label": "results", "text": "Tolerability of EOF was @ % in the lidocaine group and @ % in the control group ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24612414", "label": "results", "text": "There was no difference in postoperative pain , opioid consumption , bowel function recovery or postoperative hospital stay .", "sentence_id": 10}
+{"abstract_id": "24612414", "label": "conclusions", "text": "Perioperative intravenous lidocaine administered for laparoscopic colorectal cancer surgery might reduce postoperative nausea and vomiting .", "sentence_id": 11}
+{"abstract_id": "24612414", "label": "conclusions", "text": "However , a high tolerability to EOF following colorectal surgery can be achieved by laparoscopic surgery alone without other supportive treatment .", "sentence_id": 12}
+{"abstract_id": "25833732", "label": "background", "text": "Developing and evaluating interventions for patients with age-associated disorders is a rising field in psychotherapy research .", "sentence_id": 0}
+{"abstract_id": "25833732", "label": "background", "text": "Its methodological challenges include the high between-subject variability and the wealth of influencing factors associated with longer lifetime .", "sentence_id": 1}
+{"abstract_id": "25833732", "label": "background", "text": "Latent change score modeling ( LCSM ) , a technique based on structural equation modeling , may be well suited to analyzing longitudinal data sets obtained in clinical trials .", "sentence_id": 2}
+{"abstract_id": "25833732", "label": "background", "text": "Here , we used LCSM to evaluate the antidepressant effect of a combined cognitive behavioral/cognitive rehabilitation ( CB/CR ) intervention in Alzheimer 's disease ( AD ) .", "sentence_id": 3}
+{"abstract_id": "25833732", "label": "methods", "text": "LCSM was applied to predict the change in depressive symptoms from baseline as an outcome of the CORDIAL study , a randomized controlled trial involving @ patients with mild AD .", "sentence_id": 4}
+{"abstract_id": "25833732", "label": "methods", "text": "The participants underwent either the CORDIAL CB/CR program or standard treatment .", "sentence_id": 5}
+{"abstract_id": "25833732", "label": "methods", "text": "Using LCSM , the model best predicting changes in Geriatric Depression Scale scores was determined based on this data set .", "sentence_id": 6}
+{"abstract_id": "25833732", "label": "results", "text": "The best fit was achieved by a model predicting a decline in depressive symptoms between before and after testing .", "sentence_id": 7}
+{"abstract_id": "25833732", "label": "results", "text": "Assignment to the intervention group as well as female gender revealed significant effects in model fit indices , which remained stable at @ - and @-month follow-up examinations .", "sentence_id": 8}
+{"abstract_id": "25833732", "label": "results", "text": "The pre-post effect was pronounced for patients with clinically relevant depressive symptoms at baseline .", "sentence_id": 9}
+{"abstract_id": "25833732", "label": "conclusions", "text": "LCSM confirmed the antidepressant effect of the CORDIAL therapy program , which was limited to women .", "sentence_id": 10}
+{"abstract_id": "25833732", "label": "conclusions", "text": "The effect was pronounced in patients with clinically relevant depressive symptoms at baseline .", "sentence_id": 11}
+{"abstract_id": "25833732", "label": "conclusions", "text": "Methodologically , LCSM appears well suited to analyzing longitudinal data from clinical trials in aged populations , by accounting for the high between-subject variability and providing information on the differential indication of the probed intervention .", "sentence_id": 12}
+{"abstract_id": "25850425", "label": "background", "text": "The aim of this study is to examine the relationship between time in the therapeutic range ( TTR ) and clinical outcomes in heart failure patients in sinus rhythm treated with warfarin .", "sentence_id": 0}
+{"abstract_id": "25850425", "label": "results", "text": "We used data from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction ( WARCEF ) trial to assess the relationship of TTR with the WARCEF primary outcome ( ischemic stroke , intracerebral hemorrhage , or death ) , with death alone , ischemic stroke alone , major hemorrhage alone , and net clinical benefit ( primary outcome and major hemorrhage combined ) .", "sentence_id": 1}
+{"abstract_id": "25850425", "label": "results", "text": "Multivariable Cox models were used to examine how the event risk changed with TTR and to compare the high TTR , low TTR , and aspirin-treated patients , with TTR being treated as a time-dependent covariate .", "sentence_id": 2}
+{"abstract_id": "25850425", "label": "results", "text": "A total of @ patients were included in the analyses ; among whom @ were randomized to warfarin and @ were randomized to aspirin .", "sentence_id": 3}
+{"abstract_id": "25850425", "label": "results", "text": "The median ( interquartile range ) follow-up duration was @ ( @-@ @ ) years .", "sentence_id": 4}
+{"abstract_id": "25850425", "label": "results", "text": "Mean ( SD ) age was @ years , with @ % being men .", "sentence_id": 5}
+{"abstract_id": "25850425", "label": "results", "text": "The mean ( SD ) TTR was @ % ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25850425", "label": "results", "text": "Increasing TTR was significantly associated with reduction in primary outcome ( adjusted P < @ ) , death alone ( adjusted P = @ ) , and improved net clinical benefit ( adjusted P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25850425", "label": "results", "text": "A similar trend was observed for the other @ outcomes , but significance was not reached ( adjusted P = @ for ischemic stroke and adjusted P = @ for major hemorrhage ) .", "sentence_id": 8}
+{"abstract_id": "25850425", "label": "conclusions", "text": "In patients with heart failure in sinus rhythm , increasing TTR is associated with better outcome and improved net clinical benefit .", "sentence_id": 9}
+{"abstract_id": "25850425", "label": "conclusions", "text": "Patients in whom good quality anticoagulation can be achieved may benefit from the use of anticoagulants .", "sentence_id": 10}
+{"abstract_id": "25098777", "label": "objective", "text": "To assess the adequacy of different amounts of local anesthetics ( LA ) in infraclavicular blockade ( ICB ) under ultrasonographic ( US ) guidance and neurostimulation and compare them to the conventional doses under neurostimulation ( NS ) .", "sentence_id": 0}
+{"abstract_id": "25098777", "label": "methods", "text": "In this study @ patients scheduled for upper limb surgery and suitable for ICB were randomly allocated to @ of @ groups : group NS ( NS alone group @ ml/kg LA ) , group FD ( full-dose US group @ ml/kg LA ) , group @ ( @ % reduced dose LA @ ml/kg ) , group @ ( @ ml/kg LA ) and group @ ( @ ml/kg LA ) .", "sentence_id": 1}
+{"abstract_id": "25098777", "label": "methods", "text": "The ICB was performed under US in conjunction with NS in all groups except group NS in which neurostimulation was used alone .", "sentence_id": 2}
+{"abstract_id": "25098777", "label": "methods", "text": "When necessary local anesthetic supplementation to the operation site was administered during surgery and propofol infusion for sedation ensued .", "sentence_id": 3}
+{"abstract_id": "25098777", "label": "methods", "text": "Evaluation of sensory and motor block was performed for each terminal nerve ( i.e. radial , ulnar , median and musculocutaneous nerves ) .", "sentence_id": 4}
+{"abstract_id": "25098777", "label": "methods", "text": "Block quality ( assessing the need for rescue LA and propofol sedation ) and duration of the block were documented .", "sentence_id": 5}
+{"abstract_id": "25098777", "label": "results", "text": "None of the patients in the FD and @ groups required any supplementation or sedation , whereas LA supplementation rates were @ % in group @ and @ % in groups @ and NS .", "sentence_id": 6}
+{"abstract_id": "25098777", "label": "results", "text": "The propofol sedation rates were @ % in group NS , @ % in group @ and @ % in group @ .", "sentence_id": 7}
+{"abstract_id": "25098777", "label": "results", "text": "Sensory block was significantly better in groups FD , @ and NS at @ min .", "sentence_id": 8}
+{"abstract_id": "25098777", "label": "results", "text": "A complete block was achieved more rapidly in all nerve territories in the full-dose group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25098777", "label": "results", "text": "Block duration was longest in group FD and was significantly longer in group @ than in the other two groups ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25098777", "label": "conclusions", "text": "The results show that US guidance is more effective in maintenance of successful ICB than neurostimulation guidance alone and a reduction of LA doses even to @ % of conventionally used doses seems possible with US guidance .", "sentence_id": 11}
+{"abstract_id": "25098777", "label": "conclusions", "text": "This article is published in English .", "sentence_id": 12}
+{"abstract_id": "25074072", "label": "objective", "text": "This study aimed to compare the effectiveness and safety of triphasic combined oral contraceptives ( OCs ) containing ethinyl estradiol ( EE ) and norgestimate ( NGM ) and biphasic combined OCs containing EE and desogestrel ( DSG ) in the treatment of mild to moderate acne .", "sentence_id": 0}
+{"abstract_id": "25074072", "label": "methods", "text": "This was an investigator-blinded , randomized , parallel group trial conducted at @ centers in Thailand .", "sentence_id": 1}
+{"abstract_id": "25074072", "label": "methods", "text": "Female subjects @-@ years old were assigned to one or the other OCs and evaluated for efficacy and safety parameters at the baseline visit and after @ , @ and @ months of treatment .", "sentence_id": 2}
+{"abstract_id": "25074072", "label": "results", "text": "Among @ randomized subjects , data from @ subjects in the EE/NGM group and @ subjects in the EE/DSG group were analyzed .", "sentence_id": 3}
+{"abstract_id": "25074072", "label": "results", "text": "After @ months of treatment with EE/NGM and EE/DSG , no differences between formulations were found for the decrease in total acne lesion counts ( @ % vs. @ % , respectively , p = @ ) or facial improvement score .", "sentence_id": 4}
+{"abstract_id": "25074072", "label": "results", "text": "More women using EE/NGM showed a decrease in severity of facial seborrhea than those using EE/DSG ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25074072", "label": "results", "text": "No changes in weight were noted in either group as compared to baseline .", "sentence_id": 6}
+{"abstract_id": "25074072", "label": "conclusions", "text": "Multiphasic OCs containing EE/NGM and EE/DSG provided comparable efficacy and tolerability in the treatment of acne .", "sentence_id": 7}
+{"abstract_id": "25074072", "label": "conclusions", "text": "However , EE/NGM had a more beneficial effect on facial seborrhea reduction than EE/DSG .", "sentence_id": 8}
+{"abstract_id": "25074072", "label": "conclusions", "text": "EE/NGM and EE/DSG are multiphasic OCs , which were shown to be clinically equally effective for mild to moderate facial acne , and the multiphasic combined OC with NGM was more effective for women with facial seborrhea .", "sentence_id": 9}
+{"abstract_id": "25074072", "label": "conclusions", "text": "Clinicians may apply the results of this study when considering treatment options for facial acne and seborrhea .", "sentence_id": 10}
+{"abstract_id": "24305424", "label": "background", "text": "Forehead and glabella rhytides are treated mostly with neurotoxins , although some practitioners prefer the concurrent use of fillers .", "sentence_id": 0}
+{"abstract_id": "24305424", "label": "background", "text": "It has been suggested that combination treatments can result in a better overall improvement .", "sentence_id": 1}
+{"abstract_id": "24305424", "label": "objective", "text": "To compare the safety and effectiveness of treatment of forehead and glabellar lines with botulinum toxin A alone versus botulinum toxin A and filler .", "sentence_id": 2}
+{"abstract_id": "24305424", "label": "methods", "text": "Split-face , randomized control trial .", "sentence_id": 3}
+{"abstract_id": "24305424", "label": "methods", "text": "Twenty subjects with forehead/glabellar rhytide complex ( static and dynamic creases ) enrolled .", "sentence_id": 4}
+{"abstract_id": "24305424", "label": "methods", "text": "Subjects were randomized and injected with botulinum toxin alone on one side of the forehead/glabella and hyaluronic acid filler followed by botulinum toxin on the other side .", "sentence_id": 5}
+{"abstract_id": "24305424", "label": "methods", "text": "Blinded ratings were obtained to assess the effectiveness of treatment for static and dynamic rhytides , respectively , at @-week , @-week , @-month , and @-month follow-up visits .", "sentence_id": 6}
+{"abstract_id": "24305424", "label": "methods", "text": "Subjects performed a self-evaluation at the end of the study .", "sentence_id": 7}
+{"abstract_id": "24305424", "label": "methods", "text": "Adverse events were recorded .", "sentence_id": 8}
+{"abstract_id": "24305424", "label": "results", "text": "Ratings of both treatments showed comparable efficacy , with @ % of subjects experiencing improvement from baseline regardless of treatment type at weeks @ , @ , and @ .", "sentence_id": 9}
+{"abstract_id": "24305424", "label": "results", "text": "Combination treatment produced longer-lasting results in dynamic forehead wrinkles , and greater static and dynamic wrinkle reduction in the glabella at week @ .", "sentence_id": 10}
+{"abstract_id": "24305424", "label": "results", "text": "Subject self-evaluations showed that both treatments were effective , with a nominal preference for combination treatment .", "sentence_id": 11}
+{"abstract_id": "24305424", "label": "conclusions", "text": "Glabella and forehead lines can be effectively and safely reduced with neurotoxin alone as well as neurotoxin in combination with fillers .", "sentence_id": 12}
+{"abstract_id": "24305424", "label": "conclusions", "text": "Combination treatment may provide a slightly better cumulative benefit and also increase the persistence of effect .", "sentence_id": 13}
+{"abstract_id": "24797938", "label": "objective", "text": "Remote ischemic preconditioning ( RIPC ) by repeated brief limb ischemia/reperfusion reduces myocardial injury in patients undergoing coronary artery bypass grafting ( CABG ) .", "sentence_id": 0}
+{"abstract_id": "24797938", "label": "objective", "text": "Activation of signal transducer and activator of transcription @ ( STAT@ ) in left ventricular ( LV ) myocardium at early reperfusion is associated with such protection .", "sentence_id": 1}
+{"abstract_id": "24797938", "label": "objective", "text": "Autophagy , i.e. , removal of dysfunctional cellular components through lysosomes , has been proposed as one mechanism of cardioprotection .", "sentence_id": 2}
+{"abstract_id": "24797938", "label": "objective", "text": "Therefore , we analyzed whether or not the protection by RIPC is associated with activated autophagy .", "sentence_id": 3}
+{"abstract_id": "24797938", "label": "methods", "text": "CABG patients were randomized to undergo RIPC ( @ min blood pressure cuff inflation/@ min deflation ) or placebo ( cuff deflated ) before skin incision ( n = @/@ ) .", "sentence_id": 4}
+{"abstract_id": "24797938", "label": "methods", "text": "Transmural myocardial biopsies were taken from the LV before cardioplegia ( baseline ) and at early ( @-@ min ) reperfusion .", "sentence_id": 5}
+{"abstract_id": "24797938", "label": "methods", "text": "RIPC-induced protection was reflected by decreased serum troponin I concentration area under the curve ( @ versus @ ng/ml @ h , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24797938", "label": "methods", "text": "Western blotting for beclin-@-phosphorylation and protein expression of autophagy-related gene @-@ ( ATG@-@ ) complex , light chain @ ( LC@ ) , parkin , and p@ was performed .", "sentence_id": 7}
+{"abstract_id": "24797938", "label": "methods", "text": "STAT@ - , STAT@ - and extracellular signal-regulated protein kinase @/@ ( ERK@/@ ) - phosphorylation was used as positive control to confirm signal activation by ischemia/reperfusion .", "sentence_id": 8}
+{"abstract_id": "24797938", "label": "results", "text": "Signals of all analyzed autophagy proteins did not differ between baseline and early reperfusion and not between RIPC and placebo .", "sentence_id": 9}
+{"abstract_id": "24797938", "label": "results", "text": "STAT@-phosphorylation was greater at early reperfusion only with RIPC ( @-fold , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24797938", "label": "results", "text": "STAT@ - and ERK@/@-phosphorylation were greater at early reperfusion with placebo and RIPC ( @-fold versus baseline , p@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24797938", "label": "conclusions", "text": "Protection through RIPC in patients undergoing CABG surgery does not appear to be associated with enhanced autophagy in LV myocardium at early reperfusion .", "sentence_id": 12}
+{"abstract_id": "25055152", "label": "objective", "text": "The aim of this study was to evaluate the treatment effect of diquafosol @ % with preservative-free sodium hyaluronate @ % eye drops in dry eye syndrome .", "sentence_id": 0}
+{"abstract_id": "25055152", "label": "methods", "text": "In total , @ patients with dry eye syndrome were divided randomly into @ groups .", "sentence_id": 1}
+{"abstract_id": "25055152", "label": "methods", "text": "Group @ ( @ patients ) was treated @ times daily with preserved sodium hyaluronate @ % , group @ ( @ patients ) was treated @ times daily with diquafosol @ % , and group @ ( @ patients ) was treated @ times daily with diquafosol @ % and preservative-free sodium hyaluronate @ % eye drops for @ months .", "sentence_id": 2}
+{"abstract_id": "25055152", "label": "methods", "text": "Ocular surface disease index ( OSDI ) score , tear film break-up time , Schirmer I test , corneal fluorescein staining , and impression cytology were evaluated .", "sentence_id": 3}
+{"abstract_id": "25055152", "label": "results", "text": "There were significant improvements in the OSDI score , tear film break-up time , Schirmer I score , fluorescein and Rose Bengal staining , goblet cell density , and impression cytological findings in groups @ and @ compared with those for group @ in patients with dry eye syndrome at @ , @ , and @ months ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25055152", "label": "results", "text": "There were statistically significant improvements in the OSDI score ( -@ @ , -@ @ ; P = @ ) , fluorescein ( -@ @ , -@ @ ; P = @ ) , and Rose Bengal staining ( -@ @ , -@ @ ; P = @ ) , goblet cell density ( @ @ , @ @ ; P = @ ) , and impression cytological findings ( -@ @ , -@ @ ; P = @ ) in group @ compared with those in group @ at @ months .", "sentence_id": 5}
+{"abstract_id": "25055152", "label": "conclusions", "text": "Treatment with diquafosol @ % with preservative-free sodium hyaluronate @ % was more effective than diquafosol @ % monotherapy or treatment with preserved sodium hyaluronate @ % in dry eye syndrome .", "sentence_id": 6}
+{"abstract_id": "25055152", "label": "conclusions", "text": "Preservative-free sodium hyaluronate @ % eye drops can increase the effect of diquafosol @ % in dry eye syndrome .", "sentence_id": 7}
+{"abstract_id": "24853958", "label": "background", "text": "The aim of this prospective comparative study was to compare outcomes and complications of humeral diaphyseal fracture non-unions managed with humerus interlocking nail ( HIL ) and locking compression plate ( LCP ) .", "sentence_id": 0}
+{"abstract_id": "24853958", "label": "methods", "text": "@ patients with non-union of humeral diaphyseal fractures were included in this study and were randomly allocated in two groups ; group A had @ cases treated with HIL and group B had @ cases treated with LCP .", "sentence_id": 1}
+{"abstract_id": "24853958", "label": "methods", "text": "Clinico-radiological assessments were done for each case up to @-year follow-up period .", "sentence_id": 2}
+{"abstract_id": "24853958", "label": "methods", "text": "Primary outcome measures ( time to fracture union , union rate ) and secondary outcome measures ( functional outcome and complication such as infection , malunion , delayed union , implant failure , joint stiffness and iatrogenic radial nerve palsy ) were compared between both the groups .", "sentence_id": 3}
+{"abstract_id": "24853958", "label": "methods", "text": "Disabilities of the arm , shoulder and hand ( DASH ) scoring and Steward and Hundley 's scoring system were used to assess functional outcome of the fracture fixation .", "sentence_id": 4}
+{"abstract_id": "24853958", "label": "results", "text": "There was no significant difference ( p = @ ) in terms of mean fracture union time between group A ( @ @ weeks ) and group B ( @ @ weeks ) .", "sentence_id": 5}
+{"abstract_id": "24853958", "label": "results", "text": "Group A had @ % union rate and group B had @ % union rate ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24853958", "label": "results", "text": "At the @-year follow-up visit , there was no significant difference found between both the groups regarding range of motion of shoulder and elbow joint .", "sentence_id": 7}
+{"abstract_id": "24853958", "label": "results", "text": "There was no significant difference found in final functional outcomes between both the groups on comparing DASH score ( p = @ ) and Steward and Hundley 's score ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24853958", "label": "results", "text": "In terms of complications , there was insignificant difference found between both the groups .", "sentence_id": 9}
+{"abstract_id": "24853958", "label": "conclusions", "text": "This study concludes that both the implants can be used in non-union of humeral shaft fractures with good functional outcomes and acceptable rate of complications .", "sentence_id": 10}
+{"abstract_id": "25764956", "label": "objective", "text": "The aim of the study was to compare the efficacy of a microorganism-binding ( MB ) dressing with a silver-containing hydrofiber ( SCH ) dressing in controlling the bacterial loads of heavily colonised or locally infected chronic venous leg ulcers , before surgical management with homologous skin grafts .", "sentence_id": 0}
+{"abstract_id": "25764956", "label": "methods", "text": "A randomised comparative single centre study recruited patients presenting with hard-to-heal critically colonised or locally infected leg ulcers , who could be treated with skin grafting .", "sentence_id": 1}
+{"abstract_id": "25764956", "label": "methods", "text": "Inclusion criteria included ; ulcers of vascular aetiology , over @ years old , a wound duration @ months and ankle brachial index ( ABPI ) > @ .", "sentence_id": 2}
+{"abstract_id": "25764956", "label": "methods", "text": "Patients were randomly assigned to treatment with SCH dressings ( Aquacel Ag ) or MB dressing ( Cutimed Sorbact ) .", "sentence_id": 3}
+{"abstract_id": "25764956", "label": "methods", "text": "Dressings were changed daily over a four-day observation period , after which they were taken for a skin grafting procedure .", "sentence_id": 4}
+{"abstract_id": "25764956", "label": "methods", "text": "Swab samples from ulcer beds were taken in order to quantify the bacterial load at inclusion ( D@ ) and at the end of the observation period day @ ( D@ ) .", "sentence_id": 5}
+{"abstract_id": "25764956", "label": "methods", "text": "No antibiotics were administered before or during the evaluation period .", "sentence_id": 6}
+{"abstract_id": "25764956", "label": "results", "text": "Both groups ( n = @ SCH , n = @ MB ) were similar in gender , age , pathophysiology ( both had @ patients with venous leg ulcers and @ with arterial leg ulcers ) , ulcer surface , ulcer duration , treatment-related pain and initial bacterial load .", "sentence_id": 7}
+{"abstract_id": "25764956", "label": "results", "text": "Analysing bacterial load variation showed a significant reduction of bacterial burden at D@ in both groups .", "sentence_id": 8}
+{"abstract_id": "25764956", "label": "results", "text": "In the SCH group , we found an average bacterial load reduction of @ % , with an average reduction of @ % in the MB group ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25764956", "label": "results", "text": "No serious adverse events were reported .", "sentence_id": 10}
+{"abstract_id": "25764956", "label": "conclusions", "text": "Our evaluation confirmed that MB and SCH dressings are effective in reducing the bacterial burden in critically colonised or locally infected chronic leg ulcers , without inducing adverse events , with MB dressings significantly more effective .", "sentence_id": 11}
+{"abstract_id": "25566977", "label": "objective", "text": "The effectiveness of antimicrobial prophylaxis ( AMP ) in the prevention of surgical site infection ( SSI ) following thyroid and parathyroid surgery remains uncertain .", "sentence_id": 0}
+{"abstract_id": "25566977", "label": "objective", "text": "The objective of this prospective randomized controlled trial ( Ito-RCT@ ) was to assess the effectiveness of AMP in clean neck surgery performed to treat thyroid and parathyroid disease .", "sentence_id": 1}
+{"abstract_id": "25566977", "label": "methods", "text": "Participants comprised patients scheduled for clean neck surgery for thyroid and parathyroid disease at Ito Hospital .", "sentence_id": 2}
+{"abstract_id": "25566977", "label": "methods", "text": "Patients whose surgery included sternotomy or resection of the trachea , larynx , pharynx , or esophagus were excluded .", "sentence_id": 3}
+{"abstract_id": "25566977", "label": "methods", "text": "AMP consisted of @ g of piperacillin ( PIPC ) ( group A , n = @ ) or @ g of cefazolin ( CEZ ) ( group B , n = @ ) administered intravenously immediately after endotracheal intubation .", "sentence_id": 4}
+{"abstract_id": "25566977", "label": "methods", "text": "Patients in the control group ( Group C , n = @,@ ) did not receive AMP .", "sentence_id": 5}
+{"abstract_id": "25566977", "label": "results", "text": "Statistical analysis was performed to compare the AMP group ( Group A + Group B ) with the control group ( Group C ) .", "sentence_id": 6}
+{"abstract_id": "25566977", "label": "results", "text": "Drug-induced acute reactions correlated to PIPC or CEZ did not occur in the AMP group .", "sentence_id": 7}
+{"abstract_id": "25566977", "label": "results", "text": "No significant differences in the postoperative incidence of liver or renal dysfunction were seen between the AMP and control groups .", "sentence_id": 8}
+{"abstract_id": "25566977", "label": "results", "text": "Postoperative incidence of urinary tract infection was significantly higher in the control group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25566977", "label": "results", "text": "The incidence of SSI events was very low , with only @ event ( @ % ) in the AMP group and @ events ( @ % ) in the control group , and this difference between groups was not significant ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25566977", "label": "conclusions", "text": "AMP is not necessary to prevent SSI after clean thyroid or parathyroid surgery .", "sentence_id": 11}
+{"abstract_id": "25294097", "label": "objective", "text": "To investigate how suppression of endogenous testosterone during an @-week strength training period influences the activity of satellite cells and myonuclei .", "sentence_id": 0}
+{"abstract_id": "25294097", "label": "methods", "text": "Twenty-two moderately trained young men participated in this randomized , placebo-controlled , and double-blinded intervention study .", "sentence_id": 1}
+{"abstract_id": "25294097", "label": "methods", "text": "The participants were randomized to treatment with a GnRH analogue , goserelin ( n = @ ) , which suppresses testosterone or placebo ( n = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25294097", "label": "methods", "text": "The strength training period of @ weeks started after @ weeks of treatment and included exercises for all major muscles .", "sentence_id": 3}
+{"abstract_id": "25294097", "label": "methods", "text": "Biopsies were obtained from the mid-portion of the vastus lateralis muscle .", "sentence_id": 4}
+{"abstract_id": "25294097", "label": "results", "text": "Testosterone resting level in goserelin was @-@ times lower compared with placebo , and the training-induced increase in the level of testosterone was abolished in goserelin .", "sentence_id": 5}
+{"abstract_id": "25294097", "label": "results", "text": "Training increased satellite cells number in type II fibres by @ % in placebo and by @ % in goserelin ( P < @ ) , whereas the myonuclear number significantly increased by @ % in type II fibres in placebo and remained unchanged in goserelin ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25294097", "label": "results", "text": "No changes in satellite cells and myonuclei were seen in type I fibres in either group .", "sentence_id": 7}
+{"abstract_id": "25294097", "label": "results", "text": "Data from the microarray analysis indicated that low testosterone affects the bone morphogenetic proteins signalling , which might regulate proliferation vs. differentiation of satellite cells .", "sentence_id": 8}
+{"abstract_id": "25294097", "label": "conclusions", "text": "Eight weeks of strength training enhances the myonuclear number in type II fibres , and this is largely blocked by the suppression of testosterone .", "sentence_id": 9}
+{"abstract_id": "25294097", "label": "conclusions", "text": "The data indicate that low testosterone levels could reduce the differentiation of satellite cells to myonuclei via the bone morphogenetic proteins signalling pathway , resulting in reduced increases in lean leg mass .", "sentence_id": 10}
+{"abstract_id": "24577287", "label": "objective", "text": "A previous pilot trial evaluating computer-based training for cognitive-behavioral therapy ( CBT@CBT ) in @ heterogeneous substance users ( alcohol , marijuana , cocaine , and opioids ) demonstrated preliminary support for its efficacy in the context of a community-based outpatient clinic .", "sentence_id": 0}
+{"abstract_id": "24577287", "label": "objective", "text": "The authors conducted a more definitive trial in a larger , more homogeneous sample .", "sentence_id": 1}
+{"abstract_id": "24577287", "label": "methods", "text": "In this randomized clinical trial , @ cocaine-dependent individuals maintained on methadone were randomly assigned to standard methadone maintenance or methadone maintenance with weekly access to CBT@CBT , with seven modules delivered within an @-week trial .", "sentence_id": 2}
+{"abstract_id": "24577287", "label": "results", "text": "Treatment retention and data availability were high and comparable across the treatment conditions .", "sentence_id": 3}
+{"abstract_id": "24577287", "label": "results", "text": "Participants assigned to the CBT@CBT condition were significantly more likely to attain @ or more consecutive weeks of abstinence from cocaine ( @ % compared with @ % ; p < @ , odds ratio = @ ) .", "sentence_id": 4}
+{"abstract_id": "24577287", "label": "results", "text": "The group assigned to CBT@CBT also had better outcomes on most dimensions , including urine specimens negative for all drugs , but these reached statistical significance only for individuals completing the @-week trial ( N = @ ) .", "sentence_id": 5}
+{"abstract_id": "24577287", "label": "results", "text": "Follow-up data collected @ months after treatment termination were available for @ % of the randomized sample ; these data indicate continued improvement for those assigned to the CBT@CBT group , replicating previous findings regarding its durability .", "sentence_id": 6}
+{"abstract_id": "24577287", "label": "conclusions", "text": "This trial replicates earlier findings indicating that CBT@CBT is an effective adjunct to addiction treatment with durable effects .", "sentence_id": 7}
+{"abstract_id": "24577287", "label": "conclusions", "text": "CBT@CBT is an easily disseminable strategy for broadening the availability of CBT , even in challenging populations such as cocaine-dependent individuals enrolled in methadone maintenance programs .", "sentence_id": 8}
+{"abstract_id": "25837829", "label": "background", "text": "Hepatitis C virus ( HCV ) genotype @ accounts for about @ % of global HCV infections .", "sentence_id": 0}
+{"abstract_id": "25837829", "label": "background", "text": "Because interferon-containing treatments for genotype @ infection have low efficacy and poor tolerability , an unmet need exists for effective all-oral regimens .", "sentence_id": 1}
+{"abstract_id": "25837829", "label": "background", "text": "We examined the efficacy and safety of an all-oral interferon-free regimen of ombitasvir , an NS@A inhibitor , and paritaprevir ( ABT-@ ) , an NS@/@A protease inhibitor dosed with ritonavir ( ombitasvir plus paritaprevir plus ritonavir ) , given with or without ribavirin .", "sentence_id": 2}
+{"abstract_id": "25837829", "label": "methods", "text": "In this multicentre ongoing phase @b , randomised , open-label combination trial ( PEARL-I ) , patients were recruited from academic , public , and private hospitals and clinics in France , Hungary , Italy , Poland , Romania , Spain , Turkey , and the USA .", "sentence_id": 3}
+{"abstract_id": "25837829", "label": "methods", "text": "Eligible participants were aged @-@ years with non-cirrhotic , chronic HCV genotype @ infection ( documented @ months before screening ) and plasma HCV RNA levels higher than @,@ IU/mL .", "sentence_id": 4}
+{"abstract_id": "25837829", "label": "methods", "text": "Previously untreated ( treatment-naive ) patients were randomly assigned ( @:@ ) by computer-generated randomisation lists to receive once-daily ombitasvir ( @ mg ) plus paritaprevir ( @ mg ) plus ritonavir ( @ mg ) with or without weight-based ribavirin for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25837829", "label": "methods", "text": "Previously treated ( treatment-experienced ) patients who had received pegylated interferon plus ribavirin all received the ribavirin-containing regimen .", "sentence_id": 6}
+{"abstract_id": "25837829", "label": "methods", "text": "The primary endpoint was a sustained virological response ( HCV RNA < @ IU/mL ) @ weeks after the end of treatment ( SVR@ ) .", "sentence_id": 7}
+{"abstract_id": "25837829", "label": "methods", "text": "Analysis was by intention to treat .", "sentence_id": 8}
+{"abstract_id": "25837829", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25837829", "label": "results", "text": "Between Aug @ , @ , and Nov @ , @ , @ patients with HCV infection were screened , of whom @ were infected with genotype @ patients were randomly assigned to treatment and received at least one dose of study medication ; @ patients were treatment-naive , of whom @ received ombitasvir plus paritaprevir plus ritonavir and @ received ombitasvir plus paritaprevir plus ritonavir with ribavirin , and @ treatment-experienced patients received the ribavirin-containing regimen .", "sentence_id": 10}
+{"abstract_id": "25837829", "label": "results", "text": "In previously untreated patients , SVR@ rates were @ % ( @/@ -LSB- @ % CI @-@ -RSB- ) in the ribavirin-containing regimen and @ % ( @/@ -LSB- @ % CI @-@ -RSB- ) in the ribavirin-free regimen .", "sentence_id": 11}
+{"abstract_id": "25837829", "label": "results", "text": "No statistically significant differences in SVR@ rates were noted between the treatment-naive groups ( mean difference -@ % -LSB- @ % CI -@ to @ -RSB- ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25837829", "label": "results", "text": "All treatment-experienced patients achieved SVR@ ( @/@ ; @ % -LSB- @ % CI @-@ -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "25837829", "label": "results", "text": "In the ribavirin-free group , two ( @ % ) of @ treatment-naive patients had virological relapse , and one ( @ % ) of @ had virological breakthrough ; no virological failures were recorded in the ribavirin-containing regimen .", "sentence_id": 14}
+{"abstract_id": "25837829", "label": "results", "text": "The most common adverse event was headache ( @ -LSB- @ % -RSB- of @ treatment-experienced patients and @ -LSB- @ % -RSB- of @ treatment-naive patients ) .", "sentence_id": 15}
+{"abstract_id": "25837829", "label": "results", "text": "No adverse event-related discontinuations or dose interruptions of study medications , including ribavirin , were noted , and only four patients ( @ % ) of @ receiving ribavirin required dose modification for haemoglobin less than @ g/L or anaemia .", "sentence_id": 16}
+{"abstract_id": "25837829", "label": "conclusions", "text": "An interferon-free regimen of ombitasvir plus paritaprevir plus ritonavir with or without ribavirin achieved high sustained virological response rates at @ weeks after the end of treatment and was generally well tolerated , with low rates of anaemia and treatment discontinuation in non-cirrhotic previously untreated and previously treated patients with HCV genotype @ infection .", "sentence_id": 17}
+{"abstract_id": "25715991", "label": "background", "text": "Defibrillation testing by induction and termination of ventricular fibrillation is widely done at the time of implantation of implantable cardioverter defibrillators ( ICDs ) .", "sentence_id": 0}
+{"abstract_id": "25715991", "label": "background", "text": "We aimed to compare the efficacy and safety of ICD implantation without defibrillation testing versus the standard of ICD implantation with defibrillation testing .", "sentence_id": 1}
+{"abstract_id": "25715991", "label": "methods", "text": "In this single-blind , randomised , multicentre , non-inferiority trial ( Shockless IMPLant Evaluation -LSB- SIMPLE -RSB- ) , we recruited patients aged older than @ years receiving their first ICD for standard indications at @ hospitals in @ countries worldwide .", "sentence_id": 2}
+{"abstract_id": "25715991", "label": "methods", "text": "Exclusion criteria included pregnancy , awaiting transplantation , particpation in another randomised trial , unavailability for follow-up , or if it was expected that the ICD would have to be implanted on the right-hand side of the chest .", "sentence_id": 3}
+{"abstract_id": "25715991", "label": "methods", "text": "Patients undergoing initial implantation of a Boston Scientific ICD were randomly assigned ( @:@ ) using a computer-generated sequence to have either defibrillation testing ( testing group ) or not ( no-testing group ) .", "sentence_id": 4}
+{"abstract_id": "25715991", "label": "methods", "text": "We used random block sizes to conceal treatment allocation from the patients , and randomisation was stratified by clinical centre .", "sentence_id": 5}
+{"abstract_id": "25715991", "label": "methods", "text": "Our primary efficacy analysis tested the intention-to-treat population for non-inferiority of no-testing versus testing by use of a composite outcome of arrhythmic death or failed appropriate shock ( ie , a shock that did not terminate a spontaneous episode of ventricular tachycardia or fibrillation ) .", "sentence_id": 6}
+{"abstract_id": "25715991", "label": "methods", "text": "The non-inferiority margin was a hazard ratio ( HR ) of @ calculated from a proportional hazards model with no-testing versus testing as the only covariate ; if the upper bound of the @ % CI was less than @ , we concluded that ICD insertion without testing was non-inferior to ICD with testing .", "sentence_id": 7}
+{"abstract_id": "25715991", "label": "methods", "text": "We examined safety with two , @ day , adverse event outcome clusters .", "sentence_id": 8}
+{"abstract_id": "25715991", "label": "methods", "text": "The trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25715991", "label": "results", "text": "Between Jan @ , @ , and April @ , @ , of @ eligible patients , @ were randomly assigned to defibrillation testing and @ to no-testing , and followed up for a mean of @ years ( SD @ ) .", "sentence_id": 10}
+{"abstract_id": "25715991", "label": "results", "text": "The primary outcome of arrhythmic death or failed appropriate shock occurred in fewer patients ( @ -LSB- @ % per year -RSB- ) in the no-testing group than patients who did receive it ( @ -LSB- @ % per year -RSB- ; HR @ , @ % CI @-@ ; pnon-inferiority < @ ) .", "sentence_id": 11}
+{"abstract_id": "25715991", "label": "results", "text": "The first safety composite outcome occurred in @ ( @ % ) of @ patients with no-testing and in @ ( @ % ) of @ patients with defibrillation testing , p = @ .", "sentence_id": 12}
+{"abstract_id": "25715991", "label": "results", "text": "The second , pre-specified safety composite outcome , which included only events most likely to be directly caused by testing , occurred in @ % of patients with no-testing and in @ % with defibrillation testing , p = @ .", "sentence_id": 13}
+{"abstract_id": "25715991", "label": "results", "text": "Heart failure needing intravenous treatment with inotropes or diuretics was the most common adverse event ( in @ -LSB- @ % -RSB- of @ patients in the no-testing group vs @ -LSB- @ % -RSB- of @ patients in the testing group , p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25715991", "label": "conclusions", "text": "Routine defibrillation testing at the time of ICD implantation is generally well tolerated , but does not improve shock efficacy or reduce arrhythmic death .", "sentence_id": 15}
+{"abstract_id": "24825870", "label": "background", "text": "Artemisinin-based combination therapy ( ACT ) has become the standard of care for the treatment of uncomplicated Plasmodium falciparum malaria .", "sentence_id": 0}
+{"abstract_id": "24825870", "label": "background", "text": "Although several ACT regimens are approved , data guiding optimal choices of ACTs are limited .", "sentence_id": 1}
+{"abstract_id": "24825870", "label": "background", "text": "We compared short - and long-term outcomes in a cohort of young Ugandan children randomized to @ leading ACTs .", "sentence_id": 2}
+{"abstract_id": "24825870", "label": "methods", "text": "Overall , @ children were randomized to artemether-lumefantrine or dihydroartemisinin-piperaquine ( DP ) at the time of the first episode of uncomplicated malaria ( median age , @ months ) .", "sentence_id": 3}
+{"abstract_id": "24825870", "label": "methods", "text": "The same treatment was given for all subsequent episodes of uncomplicated malaria and children were followed until they reached @ years of age .", "sentence_id": 4}
+{"abstract_id": "24825870", "label": "methods", "text": "The cohort included a subgroup that was human immunodeficiency virus ( HIV ) infected ( n = @ ) or HIV exposed ( n = @ ) and prescribed trimethoprim-sulfamethoxazole ( TMP-SMX ) prophylaxis .", "sentence_id": 5}
+{"abstract_id": "24825870", "label": "methods", "text": "Outcomes included time to recurrent malaria following individual treatments and the overall incidences of treatments for malaria , complicated malaria , and hospitalizations .", "sentence_id": 6}
+{"abstract_id": "24825870", "label": "results", "text": "Among children not prescribed TMP-SMX prophylaxis , @ treatments for malaria were given over @ person-years following randomization .", "sentence_id": 7}
+{"abstract_id": "24825870", "label": "results", "text": "Treatment with DP was associated with a lower hazard of recurrent malaria over the @ days after treatment ( hazard ratio , @ ; @ % confidence interval -LSB- CI -RSB- , @ -@ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24825870", "label": "results", "text": "Children randomized to DP had a lower incidence of all treatments for malaria ( incidence rate ratio -LSB- IRR -RSB- , @ ; @ % CI , @ -@ ; P = @ ) , complicated malaria ( IRR , @ ; @ % CI , @ -@ ; P < @ ) , and hospitalizations ( IRR , @ ; @ % CI , @ -@ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24825870", "label": "results", "text": "Among children prescribed TMP-SMX prophylaxis , there were no significant differences in longitudinal outcomes .", "sentence_id": 10}
+{"abstract_id": "24825870", "label": "conclusions", "text": "Compared to artemether-lumefantrine , the use of DP to treat uncomplicated malaria delayed the time to recurrent malaria and reduced the incidences of treatments for malaria , complicated malaria , and hospitalizations .", "sentence_id": 11}
+{"abstract_id": "25955443", "label": "objective", "text": "The study aimed to investigate the effectiveness of a web-based therapy programme , ` Move it to improve it ' ( Mitii ( ) ) , in children with unilateral cerebral palsy ( UCP ) on occupational performance , upper limb function , and visual perception .", "sentence_id": 0}
+{"abstract_id": "25955443", "label": "methods", "text": "Participants ( n = @ ) were matched in pairs and randomized to intervention ( Mitii for @wks ; @ males , mean age @y @mo -LSB- @y @mo -RSB- , Manual Ability Classification System level I = @ , II = @ , III = @ ) or control ( standard care ; @ males , mean age @y @mo -LSB- @y @mo -RSB- , Manual Ability Classification System level I = @ , II = @ ) .", "sentence_id": 1}
+{"abstract_id": "25955443", "label": "methods", "text": "Outcomes were the Assessment of Motor and Process Skills ( AMPS ) , Assisting Hand Assessment , Jebsen-Taylor Test of Hand Function ( JTTHF ) , Melbourne Assessment of Unilateral Upper Limb Function ( MUUL ) , Canadian Occupational Performance Measure ( COPM ) , and Test of Visual Perceptual Skills ( TVPS-@ ) .", "sentence_id": 2}
+{"abstract_id": "25955443", "label": "results", "text": "Participants completed on average @ hours of Mitii ( range @-@ @ h ) .", "sentence_id": 3}
+{"abstract_id": "25955443", "label": "results", "text": "The Mitii group demonstrated significantly greater post-intervention scores than the comparison group on the AMPS , JTTHF dominant upper limb , COPM , and TVPS-@ .", "sentence_id": 4}
+{"abstract_id": "25955443", "label": "results", "text": "The differences between groups were not clinically significant .", "sentence_id": 5}
+{"abstract_id": "25955443", "label": "results", "text": "There were no differences between groups on measures of impaired upper limb function .", "sentence_id": 6}
+{"abstract_id": "25955443", "label": "conclusions", "text": "Mitii delivers individualized , web-based therapy at home and has potential to increase therapy dose .", "sentence_id": 7}
+{"abstract_id": "25955443", "label": "conclusions", "text": "Mitii can be considered as an option to enhance occupational performance and visual perception for children with UCP .", "sentence_id": 8}
+{"abstract_id": "24682569", "label": "objective", "text": "Inappropriate implantable cardioverter defibrillators ( ICD ) therapies have been associated with multiple adverse effects , including worse quality of life and prognosis .", "sentence_id": 0}
+{"abstract_id": "24682569", "label": "objective", "text": "We evaluated the possibility of predicting atrial fibrillation ( AF ) - related inappropriate ICD shocks through continuous monitoring of device diagnostics .", "sentence_id": 1}
+{"abstract_id": "24682569", "label": "methods", "text": "@ ICD patients were prospectively followed in an observational research by @ Italian cardiology centres .", "sentence_id": 2}
+{"abstract_id": "24682569", "label": "methods", "text": "Device diagnostics stored daily information on AF duration and ventricular rate ( VR ) during AF .", "sentence_id": 3}
+{"abstract_id": "24682569", "label": "methods", "text": "Uncontrolled VR was defined as mean VR > @ beats per minute ( bpm ) and maximum VR > @ bpm .", "sentence_id": 4}
+{"abstract_id": "24682569", "label": "methods", "text": "Expert electrophysiologists reviewed the ventricular tachycardia/ventricular fibrillation ( VT/VF ) episodes electrograms , stored in the device memory , and classified appropriate detections , inappropriate detection mechanisms and ICD therapy outcomes .", "sentence_id": 5}
+{"abstract_id": "24682569", "label": "results", "text": "Over a median follow-up of @ months , @ ( @ % ) patients suffered spontaneous VT/VF , which were treated by ICD shocks in a subgroup of @ ( @ % ) patients .", "sentence_id": 6}
+{"abstract_id": "24682569", "label": "results", "text": "Inappropriate detections occurred in @ ( @ % ) patients , and inappropriate ICD shocks in @ ( @ % ) patients .", "sentence_id": 7}
+{"abstract_id": "24682569", "label": "results", "text": "AF was the cause of inappropriate shocks in @ patients .", "sentence_id": 8}
+{"abstract_id": "24682569", "label": "results", "text": "AF caused @ inappropriate shocks : @ % of all inappropriate shocks .", "sentence_id": 9}
+{"abstract_id": "24682569", "label": "results", "text": "The likelihood of experiencing AF-related inappropriate shocks was @ % at @ year and @ % at @ years .", "sentence_id": 10}
+{"abstract_id": "24682569", "label": "results", "text": "Uncontrolled VR during AF proved to be an independent predictor of AF-related inappropriate shocks ( OR = @ , p = @ ) ; an alarm set at a VR > @ bpm or @ bpm was associated with prediction of AF-related inappropriate shocks with a sensitivity of @ % or @ % , respectively .", "sentence_id": 11}
+{"abstract_id": "24682569", "label": "conclusions", "text": "AF is the most common cause of inappropriate shocks in ICD patients .", "sentence_id": 12}
+{"abstract_id": "24682569", "label": "conclusions", "text": "Continuous remote monitoring of VR during AF would promptly and efficiently predict AF-related inappropriate shocks .", "sentence_id": 13}
+{"abstract_id": "24597260", "label": "objective", "text": "To explore the effect of patient-controlled lumbar epidural combined anesthesia with Doula for labor analgesia with ropivacaine and sufentanil , and its influence on the progress of labor , and outcomes of mother and infant .", "sentence_id": 0}
+{"abstract_id": "24597260", "label": "methods", "text": "Two hundred parturients that requested labor analgesia were randomly selected by patient-controlled lumbar epidural combined anesthesia with Doula as the observation group , meanwhile another @ parturients were selected as the control group without any analgesic measurements .", "sentence_id": 1}
+{"abstract_id": "24597260", "label": "methods", "text": "Labor pain score , labor duration , blood gas analysis results , the incidence of cesarean section , neonatal asphyxia , and postpartum hemorrhage were compared between the two groups .", "sentence_id": 2}
+{"abstract_id": "24597260", "label": "results", "text": "Compared with the control group , labor analgesic effect was remarkable , the cesarean section rate was significantly reduced in observation group , and the difference was statistically significant ( p < @ ) , but with respect to the duration of labor , maternal , postpartum hemorrhage , and neonatal asphyxia , there was no statistical significance between the two groups ( p > @ ) .", "sentence_id": 3}
+{"abstract_id": "24597260", "label": "results", "text": "In the observation group regarding maternal and neonatal blood gas analysis results , PO@ was higher and PCO@ was lower than those in the control group .", "sentence_id": 4}
+{"abstract_id": "24597260", "label": "results", "text": "The differences were statistically significant ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24597260", "label": "conclusions", "text": "Labor analgesia by patient-controlled lumbar epidural combined anesthesia accompanied with Doula with ropivacaine and sufentanil is effective , safe , reliable , has no adverse effects , and reduces cesarean section rate .", "sentence_id": 6}
+{"abstract_id": "24582813", "label": "objective", "text": "Ventricular arrhythmias are common after acute myocardial infarction ( AMI ) .", "sentence_id": 0}
+{"abstract_id": "24582813", "label": "objective", "text": "Endothelin ( ET ) is a mediator of microvascular dysfunction and cardiac remodeling with arrhythmogenic potential .", "sentence_id": 1}
+{"abstract_id": "24582813", "label": "objective", "text": "The aim of this study was to assess safety and feasibility of selective ET-A receptor blockade in ST-elevation acute coronary syndrome ( STE-ACS ) within a larger randomized trial .", "sentence_id": 2}
+{"abstract_id": "24582813", "label": "methods", "text": "Patients with posterior-wall STE-ACS were randomly assigned to receive intravenous BQ-@ at @ nmol/min or placebo over @ min , starting immediately prior to primary percutaneous coronary intervention .", "sentence_id": 3}
+{"abstract_id": "24582813", "label": "methods", "text": "Twenty-four hour Holter recordings were performed during hospitalization for STE-ACS and after @-@ weeks .", "sentence_id": 4}
+{"abstract_id": "24582813", "label": "methods", "text": "The predefined primary endpoint was the documentation of ventricular tachycardia and/or late potentials at follow-up .", "sentence_id": 5}
+{"abstract_id": "24582813", "label": "results", "text": "There was no significant difference in the predefined primary endpoint at @ ( @-@ ) days ( @/@ ( @ % ) in BQ-@ treated patients vs. @/@ ( @ % ) in the placebo group , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24582813", "label": "results", "text": "At @ ( @-@ ) days , an increase in the total number of supraventricular extrasystoles ( SVES ) / @ h in patients randomized to BQ-@ ( @ ( @-@ ) beats vs. @ ( @-@ ) beats in placebo treated patients , p = @ ) occurred .", "sentence_id": 7}
+{"abstract_id": "24582813", "label": "results", "text": "This increase was also observed at @ days ( @ ( @-@ ) beats vs. @ ( @-@ ) beats in placebo treated patients , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24582813", "label": "results", "text": "There was no significant difference regarding other rhythmologic secondary endpoints between the two groups .", "sentence_id": 9}
+{"abstract_id": "24582813", "label": "conclusions", "text": "Based on the analysis of long-term ECG data , short-term administration of BQ-@ after AMI was safe .", "sentence_id": 10}
+{"abstract_id": "24582813", "label": "conclusions", "text": "Because of the small sample size , no firm conclusion regarding antiarrhythmic efficacy can be drawn .", "sentence_id": 11}
+{"abstract_id": "24619321", "label": "background", "text": "Hypertension self-management has been shown to improve systolic blood pressure ( BP ) control , but longer-term economic and clinical impacts are unknown .", "sentence_id": 0}
+{"abstract_id": "24619321", "label": "background", "text": "The purpose of this article is to examine clinical and economic outcomes @ months after completion of a hypertension self-management trial .", "sentence_id": 1}
+{"abstract_id": "24619321", "label": "results", "text": "This study is a follow-up analysis of an @-month , @-arm , hypertension self-management trial of @ veterans with hypertension who were randomized to usual care or @ of @ interventions .", "sentence_id": 2}
+{"abstract_id": "24619321", "label": "results", "text": "Clinic-derived systolic blood pressure obtained before , during , and after the trial were estimated using linear mixed models .", "sentence_id": 3}
+{"abstract_id": "24619321", "label": "results", "text": "Inpatient admissions , outpatient expenditures , and total expenditures were estimated using generalized estimating equations .", "sentence_id": 4}
+{"abstract_id": "24619321", "label": "results", "text": "The @ telephone-based interventions were nurse-administered health behavior promotion , provider-administered medication adjustments based on hypertension treatment guidelines , or a combination of both .", "sentence_id": 5}
+{"abstract_id": "24619321", "label": "results", "text": "Intervention calls were triggered by home BP values transmitted via telemonitoring devices .", "sentence_id": 6}
+{"abstract_id": "24619321", "label": "results", "text": "Clinical and economic outcomes were examined @ months before , @ months during , and @ months after trial completion .", "sentence_id": 7}
+{"abstract_id": "24619321", "label": "results", "text": "Compared with usual care , patients randomized to the combined arm had greater improvement in proportion of BP control during and after the @-month trial and estimated proportion of BP control improved @ months after trial completion for patients in the behavioral and medication management arms .", "sentence_id": 8}
+{"abstract_id": "24619321", "label": "results", "text": "Among the patients with inadequate baseline BP control , estimated mean systolic BP was significantly lower in the combined arm as compared with usual care during and after the @-month trial .", "sentence_id": 9}
+{"abstract_id": "24619321", "label": "results", "text": "Utilization and expenditure trends were similar for patients in all @ arms .", "sentence_id": 10}
+{"abstract_id": "24619321", "label": "conclusions", "text": "Behavioral and medication management can generate systolic BP improvements that are sustained @ months after trial completion .", "sentence_id": 11}
+{"abstract_id": "24638865", "label": "background", "text": "Melanocytic nevi ( MN ) are the most important simulants of melanoma .", "sentence_id": 0}
+{"abstract_id": "24638865", "label": "background", "text": "Although acquired nevi are usually clinically stable , they may show abnormal clinical behavior .", "sentence_id": 1}
+{"abstract_id": "24638865", "label": "background", "text": "This study assessed the histological changes and prognosis of acquired MN with changing clinical behavior in Egyptian patients .", "sentence_id": 2}
+{"abstract_id": "24638865", "label": "methods", "text": "The study included @ patients that were classified into two groups ; Group A included nevi with abnormal clinical presentation and Group B included clinically typical nevi .", "sentence_id": 3}
+{"abstract_id": "24638865", "label": "results", "text": "Each group included @ patients with a predominance of female patients .", "sentence_id": 4}
+{"abstract_id": "24638865", "label": "results", "text": "Abnormal clinical presentation in Group A included altered pigmentation ( @ % ) , rapid enlargement ( @ % ) , keratotic changes ( @ % ) , inflammation ( @ % ) , ulceration ( @ % ) , and hemorrhage ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "24638865", "label": "results", "text": "Typical histological features were significantly higher ( p = @ ) in Group B ( @ % ) compared with Group A ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "24638865", "label": "results", "text": "Atypical histological features were significantly higher ( p = @ ) in Group A , with higher numbers of ulcerative and altered pigmented nevi .", "sentence_id": 7}
+{"abstract_id": "24638865", "label": "results", "text": "Malignant changes showed no significant difference ( p = @ ) between the two groups .", "sentence_id": 8}
+{"abstract_id": "24638865", "label": "results", "text": "No relapse was recorded after excision of any lesion .", "sentence_id": 9}
+{"abstract_id": "24638865", "label": "conclusions", "text": "Among Egyptians , changing clinical behavior of MN may show histological atypia but low risk of malignant transformation .", "sentence_id": 10}
+{"abstract_id": "24638865", "label": "conclusions", "text": "Early excision and follow-up of ulcerative and altered pigmented nevi are recommended .", "sentence_id": 11}
+{"abstract_id": "24273046", "label": "background", "text": "The GeparQuattro study showed that adding capecitabine or prolonging the duration of anthracycline-taxane-based neoadjuvant chemotherapy from @ to @ weeks did not increase pathological complete response ( pCR ) rates .", "sentence_id": 0}
+{"abstract_id": "24273046", "label": "background", "text": "Trastuzumab-treated patients with HER@-positive disease showed a higher pCR rate than patients with HER@-negative disease treated with chemotherapy alone .", "sentence_id": 1}
+{"abstract_id": "24273046", "label": "background", "text": "We here present disease-free ( DFS ) and overall survival ( OS ) analyses .", "sentence_id": 2}
+{"abstract_id": "24273046", "label": "methods", "text": "Patients ( n = @ ) with cT @ tumors , or negative hormone-receptor status , or positive hormone-receptor and clinically node-positive disease received four times epirubicin/cyclophosphamide and were thereafter randomly assigned to four times docetaxel ( Taxotere ) , or four times docetaxel/capecitabine over @ weeks , or four times docetaxel followed by capecitabine over @ weeks .", "sentence_id": 3}
+{"abstract_id": "24273046", "label": "methods", "text": "Patients with HER@-positive tumors received @ year of trastuzumab , starting with the first chemotherapy cycle .", "sentence_id": 4}
+{"abstract_id": "24273046", "label": "methods", "text": "Follow-up was available for a median of @ years .", "sentence_id": 5}
+{"abstract_id": "24273046", "label": "results", "text": "Outcome was not improved for patients receiving capecitabine ( HR @ ; P = @ for DFS and HR @ ; P = @ for OS ) as well as for patients receiving @ weeks of chemotherapy ( HR @ ; P = @ for DFS and HR @ ; P = @ for OS ) .", "sentence_id": 6}
+{"abstract_id": "24273046", "label": "results", "text": "Trastuzumab-treated patients with HER@-positive disease showed similar DFS ( P = @ ) but a significantly better adjusted OS ( P = @ ) when compared with patients with HER@-negative disease treated with chemotherapy alone .", "sentence_id": 7}
+{"abstract_id": "24273046", "label": "results", "text": "Recorded long-term cardiac toxicity was low .", "sentence_id": 8}
+{"abstract_id": "24273046", "label": "conclusions", "text": "Long-term results , similar to the results of pCR , do not support the use of capecitabine in the neoadjuvant setting in addition to an anthracycline-taxane-based chemotherapy .", "sentence_id": 9}
+{"abstract_id": "24273046", "label": "conclusions", "text": "However , the results support previous data showing a benefit of trastuzumab as predicted by higher pCR rates .", "sentence_id": 10}
+{"abstract_id": "24379449", "label": "objective", "text": "This randomized controlled pilot trial was conducted to evaluate the clinical efficacy of massage therapy ( MT ) for relief of symptoms of gastroesophageal reflux disease ( GERD ) .", "sentence_id": 0}
+{"abstract_id": "24379449", "label": "objective", "text": "The hypothesis was that , when compared to infants who received nonmassage therapy , infants who received MT would display fewer GERD symptoms , greater weight gain , greater amount of sleep , lower cortisol levels before and after treatment , and lower daily ( area under the curve -LSB- AUC -RSB- ) cortisol secretion .", "sentence_id": 1}
+{"abstract_id": "24379449", "label": "methods", "text": "Participants were @ infants born at term , @-@ weeks of age at enrollment , healthy except for a diagnosis of GERD by their pediatrician , and with a score of at least @ on the Infant Gastroesophageal Reflux Questionnaire-Revised ( I-GERQ-R ) .", "sentence_id": 2}
+{"abstract_id": "24379449", "label": "methods", "text": "Infants were randomized to receive either MT or a nonmassage sham treatment in their homes for @ min twice a week for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24379449", "label": "methods", "text": "Data collectors and parents were blind to study condition .", "sentence_id": 4}
+{"abstract_id": "24379449", "label": "results", "text": "GERD symptoms decreased in both groups and weight increased .", "sentence_id": 5}
+{"abstract_id": "24379449", "label": "results", "text": "Pretreatment salivary cortisol levels decreased significantly over time in the massage group while increasing in the nonmassage group .", "sentence_id": 6}
+{"abstract_id": "24379449", "label": "results", "text": "Daily cortisol level also decreased in the massage group and increased in the nonmassage group , but the difference was not significant .", "sentence_id": 7}
+{"abstract_id": "24379449", "label": "conclusions", "text": "MT administered by a professional therapist did not affect symptoms of GERD differently than a sham treatment but did decrease infant stress as measured by cortisol .", "sentence_id": 8}
+{"abstract_id": "24379449", "label": "conclusions", "text": "Research focusing on stress reduction in infants with GERD and multimodal treatments addressing GERD symptoms may yield the most effective treatment .", "sentence_id": 9}
+{"abstract_id": "25518175", "label": "objective", "text": "Rotation of femoral components could be optimized to improve function and durability of the knee joint .", "sentence_id": 0}
+{"abstract_id": "25518175", "label": "objective", "text": "The purpose of the present study was to assess rotational alignment of femoral component comparing between CT-based , custom cutting blocks and the contemporary total knee arthroplasty , instrument technique .", "sentence_id": 1}
+{"abstract_id": "25518175", "label": "methods", "text": "The prospective control study of @ patients underwent total knee arthroplasty by using PFC Sigma PS total knee design .", "sentence_id": 2}
+{"abstract_id": "25518175", "label": "methods", "text": "Rotation offemoral component was analyzed in all patients using postoperative CT scan .", "sentence_id": 3}
+{"abstract_id": "25518175", "label": "methods", "text": "Forty patients were perfonned on by using CT-based , patient-specific cutting blocks with femoral rotational axis relative to transepicondylar axis while forty patients were performed on by using contemporaly instrumentation with alignment at @ degrees external rotation from posterior condylar line .", "sentence_id": 4}
+{"abstract_id": "25518175", "label": "methods", "text": "The rotation of the femoral component with external rotation ofmore than @ degrees or internal rotation was considered outlier .", "sentence_id": 5}
+{"abstract_id": "25518175", "label": "results", "text": "There was no statistically significant difference among ages , gender ; BMI , pre-operative mechanical axis between the two groups .", "sentence_id": 6}
+{"abstract_id": "25518175", "label": "results", "text": "There were eleven outliers in conventional group ( range , @ degrees ofexternal rotation to @ degrees of internal rotation ) , three femoral components were in excessive external rotation with the angle of more than @ degrees and eight femnoral components were in internal rotation .", "sentence_id": 7}
+{"abstract_id": "25518175", "label": "results", "text": "In contrast with custom cutting block group was no outliers offemoral rotation .", "sentence_id": 8}
+{"abstract_id": "25518175", "label": "results", "text": "The average rotational alignment was @ + / - @ external rotation from epicondylar axis in custom cutting group and @ + / - @ in contemporary group .", "sentence_id": 9}
+{"abstract_id": "25518175", "label": "conclusions", "text": "Custom cutting , block technique significantly reduced the outlier of the femoral component rotation and aided in positioning of the femoral component in optimal alignment .", "sentence_id": 10}
+{"abstract_id": "25518175", "label": "conclusions", "text": "The improvement of femoral rotation showed no difference in clinical outcome between the two groups .", "sentence_id": 11}
+{"abstract_id": "25068233", "label": "objective", "text": "The purpose of the study was to analyze the potential capacity of a dietary supplement , based on gamma linolenic acid , vitamin E , vitamin C , beta-carotene , coenzyme Q@ and Vitis Vitifera , to reduce side effects , in particular the dry skin , erythema and desquamation , due to treatment with oral isotretinoin , and evaluate the ability of the product to increase adherence to therapy in patients with acne .", "sentence_id": 0}
+{"abstract_id": "25068233", "label": "methods", "text": "Forty-eight patients with nodular acne ( @ females and @ males ) were randomly divided into @ groups : @ received isotretinoin therapy ( @-@ mg/day ) for @ months associated to dietary supplement ( twice a day ) , while the other @ patients received only isotretinoin ( @-@ mg/day ) for @ months .", "sentence_id": 1}
+{"abstract_id": "25068233", "label": "methods", "text": "For all patients the degree of acne severity , through GAGS ( Global Acne Grading System ) , the sebum production by Sebutape , the hydration by Corneometer and the erythema by Mexameter , were measured .", "sentence_id": 2}
+{"abstract_id": "25068233", "label": "methods", "text": "We have also evaluated the adherence to treatment , asking to patients how many days a week they follow the therapy .", "sentence_id": 3}
+{"abstract_id": "25068233", "label": "results", "text": "Patients treated with dietary supplement had lower side effects , with a less degree of erythema and dryness , and greater degree of hydration ; a greater adherence to therapy was also reported .", "sentence_id": 4}
+{"abstract_id": "25068233", "label": "conclusions", "text": "Thanks to antioxidant and moisturizing properties , the dietary supplement containing gamma linolenic acid , vitamin E , vitamin C , betacarotene , coenzyme Q@ and Vitis Vitifera , can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin .", "sentence_id": 5}
+{"abstract_id": "25967269", "label": "background", "text": "Integrating antenatal care ( ANC ) and HIV care may improve uptake and retention in services along the prevention of mother-to-child transmission ( PMTCT ) cascade .", "sentence_id": 0}
+{"abstract_id": "25967269", "label": "background", "text": "This study aimed to determine whether integration of HIV services into ANC settings improves PMTCT service utilization outcomes .", "sentence_id": 1}
+{"abstract_id": "25967269", "label": "methods", "text": "ANC clinics in rural Kenya were randomized to integrated ( @ clinics , @ women ) or nonintegrated ( @ clinics , @ women ) services .", "sentence_id": 2}
+{"abstract_id": "25967269", "label": "methods", "text": "Intervention clinics provided all HIV services , including highly active antiretroviral therapy ( HAART ) , whereas control clinics provided PMTCT services but referred women to HIV care clinics within the same facility .", "sentence_id": 3}
+{"abstract_id": "25967269", "label": "methods", "text": "PMTCT utilization outcomes among HIV-infected women ( maternal HIV care enrollment , HAART initiation , and @-month infant HIV testing uptake ) were compared using generalized estimating equations and Cox regression .", "sentence_id": 4}
+{"abstract_id": "25967269", "label": "results", "text": "HIV care enrollment was higher in intervention compared with control clinics -LSB- @ % versus @ % ; odds ratio = @ , @ % confidence interval ( CI ) : @ to @ -RSB- .", "sentence_id": 5}
+{"abstract_id": "25967269", "label": "results", "text": "Median time to enrollment was significantly shorter among intervention arm women ( @ versus @ days , hazard ratio = @ , @ % CI : @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25967269", "label": "results", "text": "Eligible women in the intervention arm were more likely to initiate HAART ( @ % versus @ % ; odds ratio = @ , @ % CI : @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25967269", "label": "results", "text": "Infant testing was more common in the intervention arm ( @ % versus @ % ) , however , not statistically different .", "sentence_id": 8}
+{"abstract_id": "25967269", "label": "results", "text": "No significant differences were detected in postnatal service uptake or maternal retention .", "sentence_id": 9}
+{"abstract_id": "25967269", "label": "conclusions", "text": "Service integration increased maternal HIV care enrollment and HAART uptake .", "sentence_id": 10}
+{"abstract_id": "25967269", "label": "conclusions", "text": "However , PMTCT utilization outcomes were still suboptimal , and postnatal service utilization remained poor in both study arms .", "sentence_id": 11}
+{"abstract_id": "25967269", "label": "conclusions", "text": "Further improvements in the PMTCT cascade will require additional research and interventions .", "sentence_id": 12}
+{"abstract_id": "24512252", "label": "background", "text": "The use of @-alpha-hydroxyprogesterone caproate ( @P ) has been shown to reduce preterm delivery in women who have had a prior preterm birth .", "sentence_id": 0}
+{"abstract_id": "24512252", "label": "background", "text": "The role of @P in women with arrested preterm labor is less certain .", "sentence_id": 1}
+{"abstract_id": "24512252", "label": "objective", "text": "To compare the preterm birth rate and neonatal outcome in women with arrested preterm labor randomized to receive @P or placebo .", "sentence_id": 2}
+{"abstract_id": "24512252", "label": "methods", "text": "Women with arrested preterm labor were randomized to weekly injections of either @P ( @mg ) or placebo .", "sentence_id": 3}
+{"abstract_id": "24512252", "label": "methods", "text": "Maternal and neonatal outcome were evaluated .", "sentence_id": 4}
+{"abstract_id": "24512252", "label": "results", "text": "Forty-five singleton pregnancies were randomized after successful tocolysis ; @ received @P while @ got placebo .", "sentence_id": 5}
+{"abstract_id": "24512252", "label": "results", "text": "Gestational age at delivery ( p = @ ) and the interval from treatment to delivery ( p = @ ) were not affected by @P .", "sentence_id": 6}
+{"abstract_id": "24512252", "label": "results", "text": "Significantly less women in the @P group delivered at < @ weeks ( @ versus @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24512252", "label": "results", "text": "There was also a significant reduction in the risk of neonatal sepsis ( p = @ ) and gr III/IV intraventricular hemorrhage ( IVH ) ( p = @ ) in the @P group .", "sentence_id": 8}
+{"abstract_id": "24512252", "label": "conclusions", "text": "In this study , @P did not delay the interval to delivery after successful preterm labor , but births < @ weeks as well as neonatal sepsis and IVH were reduced by @P treatment .", "sentence_id": 9}
+{"abstract_id": "24909625", "label": "conclusions", "text": "Responses with greater amplitude were recorded when carrier frequencies were modulated at @ , @ , and @ Hz .", "sentence_id": 0}
+{"abstract_id": "24909625", "label": "conclusions", "text": "These responses can be recorded even in patients with significant sensorineural hearing loss , from the sternocleidomastoid ( SCM ) muscle for a @ Hz tone , @ % modulated at @ Hz .", "sentence_id": 1}
+{"abstract_id": "24909625", "label": "objective", "text": "To determine the best carrier and modulating frequencies to evoke steady-state myogenic responses .", "sentence_id": 2}
+{"abstract_id": "24909625", "label": "methods", "text": "The present study investigated @ ears of @ normal-hearing young adults , with carrier frequencies of @ , @ , and @ Hz , modulated at @ , @ , @ , @ , @ , @ , and @ Hz , with an intensity of @ dBA .", "sentence_id": 3}
+{"abstract_id": "24909625", "label": "methods", "text": "Furthermore , we observed responses evoked by stimulus carrier frequency of @ Hz , modulated at @ Hz , with an intensity of @ dBA in a group of five subjects with severe sensorineural loss .", "sentence_id": 4}
+{"abstract_id": "24909625", "label": "results", "text": "Responses were found for all stimuli studied ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24909625", "label": "results", "text": "Modulated stimuli at frequencies of @ , @ , and @ Hz evoked better steady-state vestibular evoked myogenic potential ( S-VEMP ) ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24909625", "label": "results", "text": "No statistically significant differences were found between the group of normal hearers and the group of subjects with hearing loss ( p = @ ) , for the stimulus used .", "sentence_id": 7}
+{"abstract_id": "25198235", "label": "objective", "text": "To examine the effects of a ten week deadlift training program on peak torque and agonist-antagonist coactivation .", "sentence_id": 0}
+{"abstract_id": "25198235", "label": "methods", "text": "Fifty-four untrained subjects ( mean age = @ years ) participated in this investigation , and were randomly assigned to a training ( males , n = @ ; females , n = @ ) or control ( males , n = @ ; females , n = @ ) group .", "sentence_id": 1}
+{"abstract_id": "25198235", "label": "methods", "text": "The subjects in the training group performed deadlifts twice per week .", "sentence_id": 2}
+{"abstract_id": "25198235", "label": "methods", "text": "Isometric peak torque for the leg extensors and flexors and surface electromyographic ( EMG ) amplitude for the superficial quadriceps and biceps femoris muscles were assessed .", "sentence_id": 3}
+{"abstract_id": "25198235", "label": "results", "text": "Deadlift training increased leg extension peak torque for the males ( P = @ , Cohen 's d = @ ) and females ( P = @ , d = @ ) .", "sentence_id": 4}
+{"abstract_id": "25198235", "label": "results", "text": "Leg flexion peak torque improved for the females ( P = @ , d = @ ) .", "sentence_id": 5}
+{"abstract_id": "25198235", "label": "results", "text": "Increased EMG amplitude for the superficial quadriceps femoris muscles when they served as agonists was demonstrated for the females ( P = @ , d = @ ) , but not the males ( P = @ , d = @ ) .", "sentence_id": 6}
+{"abstract_id": "25198235", "label": "results", "text": "For both sexes , the effect sizes for the decline in biceps femoris coactivation were large .", "sentence_id": 7}
+{"abstract_id": "25198235", "label": "conclusions", "text": "Deadlift training elicited improvements in strength and agonist-antagonist coactivation in untrained subjects , and particularly , novice females .", "sentence_id": 8}
+{"abstract_id": "24762108", "label": "objective", "text": "Kisspeptin-@ , an endogenous naturally occurring ligand of the G protein-coupled receptor-@ , stimulates GnRH-gonadotropin secretion and suppresses metastases in animal models of cancer but is subject to rapid degradation and inactivation .", "sentence_id": 0}
+{"abstract_id": "24762108", "label": "objective", "text": "TAK-@ is an investigational oligopeptide analog of the fully active @-amino acid C terminus of kisspeptin-@ .", "sentence_id": 1}
+{"abstract_id": "24762108", "label": "objective", "text": "This phase @ study evaluated the safety , pharmacokinetics , and pharmacodynamics of TAK-@ in healthy subjects and patients with prostate cancer ( PC ) .", "sentence_id": 2}
+{"abstract_id": "24762108", "label": "methods", "text": "Healthy subjects aged @ years or older received TAK-@ sc as a single-bolus or @-hour infusion ( @-@ mg/d ; part A ) and as a @-day sc administration ( @-@ mg/d ; part B ) .", "sentence_id": 3}
+{"abstract_id": "24762108", "label": "methods", "text": "In a subsequent , open-label , phase @ study in PC patients aged @-@ years , TAK-@ was given as a @-month depot formulation .", "sentence_id": 4}
+{"abstract_id": "24762108", "label": "results", "text": "Eighty-two healthy subjects received TAK-@ ; @ received placebo .", "sentence_id": 5}
+{"abstract_id": "24762108", "label": "results", "text": "Grades @-@ adverse events were reported in @ % of subjects during TAK-@ treatment .", "sentence_id": 6}
+{"abstract_id": "24762108", "label": "results", "text": "All dosing regimens resulted in dose-proportional exposures .", "sentence_id": 7}
+{"abstract_id": "24762108", "label": "results", "text": "The maximum observed plasma concentration occurred after @-@ @ hours , and median terminal elimination half-life was @-@ @ hours .", "sentence_id": 8}
+{"abstract_id": "24762108", "label": "results", "text": "T increased approximately @ - to @-fold by @ hours after a single bolus or @ hour injections , whereas during the @-day infusion , at doses above @ mg/d , T dropped to below-baseline values by @ hours and reached a subsequently sustained below-castration level by day @ .", "sentence_id": 9}
+{"abstract_id": "24762108", "label": "results", "text": "In PC patients , T decreased to less than @ ng/dL in four of five patients dosed with @ or @ mg TAK-@ sc-depot injections .", "sentence_id": 10}
+{"abstract_id": "24762108", "label": "results", "text": "The prostate-specific antigen decreased greater than @ % in all patients dosed with @ mg .", "sentence_id": 11}
+{"abstract_id": "24762108", "label": "conclusions", "text": "Continuous TAK-@ infusion was well tolerated by healthy males and resulted in sustained T suppression .", "sentence_id": 12}
+{"abstract_id": "24762108", "label": "conclusions", "text": "Depot injection in patients with PC similarly reduced T and resulted in prostate-specific antigen responses .", "sentence_id": 13}
+{"abstract_id": "24786613", "label": "objective", "text": "To evaluate the clinical efficacy , safety , and costs of percutaneous occlusive balloon catheter-assisted ureteroscopic lithotripsy ( POBC-URSL ) for large impacted proximal ureteral calculi .", "sentence_id": 0}
+{"abstract_id": "24786613", "label": "methods", "text": "@ patients with impacted proximal ureteral stones @ cm in size were randomized to ureteroscopic lithotripsy ( URSL ) , POBC-URSL , and percutaneous nephrolithotomy ( PNL ) group between May @ and May @ .", "sentence_id": 1}
+{"abstract_id": "24786613", "label": "methods", "text": "For URSL , the calculi were disintegrated with the assistance of anti-retropulsion devices .", "sentence_id": 2}
+{"abstract_id": "24786613", "label": "methods", "text": "POBC-URSL was performed with the assistance of an @F percutaneous occlusive balloon catheter .", "sentence_id": 3}
+{"abstract_id": "24786613", "label": "methods", "text": "PNL was finished with the combination of an ultrasonic and a pneumatic lithotripter .", "sentence_id": 4}
+{"abstract_id": "24786613", "label": "methods", "text": "A flexible ureteroscope and a @m laser fiber were used to achieve stone-free status to a large extent for each group .", "sentence_id": 5}
+{"abstract_id": "24786613", "label": "methods", "text": "Variables studied were mean operative time , auxiliary procedure , postoperative hospital stay , operation-related complications , stone clearance rate , and treatment costs .", "sentence_id": 6}
+{"abstract_id": "24786613", "label": "results", "text": "The mean lithotripsy time for POBC-URSL was shorter than URSL , but longer than PNL ( @ minutes vs @ minutes vs @ minutes , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24786613", "label": "results", "text": "The auxiliary procedure rate and postoperative fever rate for POBC-URSL were significantly lower than URSL and comparable to PNL ( p < @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24786613", "label": "results", "text": "POBC-URSL was superior to URSL with regard to the stone clearance rate at @ days postoperatively , and as good as PNL ( @ % vs @ % vs @ % , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24786613", "label": "results", "text": "The postoperative hospital stay and hematuria rate were lower in POBC-URSL group than PNL group and similar to URSL group ( p = @ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24786613", "label": "results", "text": "The treatment costs were lowest in POBC-URSL group ( $ @ $ @ vs $ @ $ @ vs $ @ $ @ , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24786613", "label": "conclusions", "text": "For large impacted proximal ureteral calculi , POBC-URSL was associated with a higher stone clearance rate , fewer complications and costs .", "sentence_id": 12}
+{"abstract_id": "24786613", "label": "conclusions", "text": "POBC-URSL combined the advantages of URSL and PNL .", "sentence_id": 13}
+{"abstract_id": "25600444", "label": "objective", "text": "To evaluate the effect of vaginal misoprostol on intraoperative bleeding during myomectomy .", "sentence_id": 0}
+{"abstract_id": "25600444", "label": "methods", "text": "In this randomized clinical trial , @ women with myomas were randomly assigned to receive @ g misoprostol or placebo ( vitamin B@ ) @ h before surgery .", "sentence_id": 1}
+{"abstract_id": "25600444", "label": "methods", "text": "Blood loss during surgery , postoperative need for blood transfusion , and the hemoglobin level before surgery , and @ and @ h after surgery were assessed in two groups .", "sentence_id": 2}
+{"abstract_id": "25600444", "label": "results", "text": "Mean age and the mean preoperative and postoperative Hb levels were not significantly different between the two groups .", "sentence_id": 3}
+{"abstract_id": "25600444", "label": "results", "text": "Mean duration of surgery and mean estimated blood loss were significantly higher in control group .", "sentence_id": 4}
+{"abstract_id": "25600444", "label": "results", "text": "Nine ( @ % ) patients in control group needed blood transfusion while there was no need blood transfusion in misoprostol group ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25600444", "label": "conclusions", "text": "A single dose of vaginal misoprostol is effective in reducing hemorrhage during myomectomy .", "sentence_id": 6}
+{"abstract_id": "25374216", "label": "background", "text": "Hepatitis C virus ( HCV ) infection is an important cause of liver cancer in Thailand .", "sentence_id": 0}
+{"abstract_id": "25374216", "label": "background", "text": "The highest prevalence of anti-HCV positive among Thai blood donors is found in the northeastern region .", "sentence_id": 1}
+{"abstract_id": "25374216", "label": "background", "text": "The present analysis of the genotype distribution among anti-HCV positive northeastern-Thai blood donors was conducted to provide a base for the epidemiological pattern of HCV infection in this region .", "sentence_id": 2}
+{"abstract_id": "25374216", "label": "methods", "text": "A total of @ HCV seropositive healthy blood donors were randomly selected and tested for the presence of HCV-RNA by RT-PCR .", "sentence_id": 3}
+{"abstract_id": "25374216", "label": "methods", "text": "HCV-RNA positive samples were genotyped by direct sequencing at core region genomes and confirmed by phylogenetic analysis .", "sentence_id": 4}
+{"abstract_id": "25374216", "label": "results", "text": "HCV viremia was found in @ % ( @/@ ) of HCV seropositive blood donors .", "sentence_id": 5}
+{"abstract_id": "25374216", "label": "results", "text": "There were @ major genotypes distributed among this population .", "sentence_id": 6}
+{"abstract_id": "25374216", "label": "results", "text": "HCV genotype @a was the most prevalent ( @ % ) followed by genotypes @a ( @ % ) , @b ( @ % ) , @i ( @ % ) , @f ( @ % ) and @n ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25374216", "label": "conclusions", "text": "HCV genotype @a in asymptomatic infections in northeastern Thailand is significantly higher than other previous reports .", "sentence_id": 8}
+{"abstract_id": "25374216", "label": "conclusions", "text": "Subgenotype @ prevalence is less than in neighboring countries and distribution patterns differ .", "sentence_id": 9}
+{"abstract_id": "25374216", "label": "conclusions", "text": "The findings are relevant as predictors for using interferon therapy in this population .", "sentence_id": 10}
+{"abstract_id": "25329446", "label": "background", "text": "Many bacterial pathogens causing respiratory infections in children are common residents of the respiratory tract .", "sentence_id": 0}
+{"abstract_id": "25329446", "label": "background", "text": "Insight into bacterial colonization patterns and microbiota stability at a young age might elucidate healthy or susceptible conditions for development of respiratory disease .", "sentence_id": 1}
+{"abstract_id": "25329446", "label": "objective", "text": "To study bacterial succession of the respiratory microbiota in the first @ years of life and its relation to respiratory health characteristics .", "sentence_id": 2}
+{"abstract_id": "25329446", "label": "methods", "text": "Upper respiratory microbiota profiles of @ healthy children at the ages of @ , @ , @ , and @ months were characterized by @S-based pyrosequencing .", "sentence_id": 3}
+{"abstract_id": "25329446", "label": "methods", "text": "We determined consecutive microbiota profiles by machine-learning algorithms and validated the findings cross-sectionally in an additional cohort of @ children per age group .", "sentence_id": 4}
+{"abstract_id": "25329446", "label": "results", "text": "Overall , we identified eight distinct microbiota profiles in the upper respiratory tract of healthy infants .", "sentence_id": 5}
+{"abstract_id": "25329446", "label": "results", "text": "Profiles could already be identified at @ months of age and were associated with microbiota stability and change over the first @ years of life .", "sentence_id": 6}
+{"abstract_id": "25329446", "label": "results", "text": "More stable patterns were marked by early presence and high abundance of Moraxella and Corynebacterium/Dolosigranulum and were positively associated with breastfeeding in the first period of life and with lower rates of parental-reported respiratory infections in the consecutive periods .", "sentence_id": 7}
+{"abstract_id": "25329446", "label": "results", "text": "Less stable profiles were marked by high abundance of Haemophilus or Streptococcus .", "sentence_id": 8}
+{"abstract_id": "25329446", "label": "conclusions", "text": "These findings provide novel insights into microbial succession in the respiratory tract in infancy and link early-life profiles to microbiota stability and respiratory health characteristics .", "sentence_id": 9}
+{"abstract_id": "25329446", "label": "conclusions", "text": "New prospective studies should elucidate potential implications of our findings for early diagnosis and prevention of respiratory infections .", "sentence_id": 10}
+{"abstract_id": "25329446", "label": "conclusions", "text": "Clinical trial registered with www.clinicaltrials.gov ( NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24843962", "label": "objective", "text": "To compare the difference in the efficacy on gait time cycle of ischemic stroke between yin-yang respiratory reinforcing and reducing needling technique ( yin-yang needling ) and the conventional acupuncture .", "sentence_id": 0}
+{"abstract_id": "24843962", "label": "methods", "text": "Sixty cases of ischemic stroke were randomized into a conventional acupuncture group and a yin-yang needling group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "24843962", "label": "methods", "text": "The basic treatment ( the control of blood pressure , blood sugar and blood lipid , the intravenous drops of ginkgo leaf extract and dipyridamole injection and vinpocetine injection ) were applied in the two groups .", "sentence_id": 2}
+{"abstract_id": "24843962", "label": "methods", "text": "Additionally , in the conventional acupuncture group , the acupoints of the Stomach Meridian of Foot-Yangming -LSB- Biguan ( ST @ ) , Liangqiu ( ST @ ) , Zusanli ( ST @ ) , Shangjuxu ( ST @ ) , Xiajuxu ( ST @ ) , etc. -RSB- were selected and stimulated with the even needling technique .", "sentence_id": 3}
+{"abstract_id": "24843962", "label": "methods", "text": "In the yin-yang needling group , the acupoints of yin meridians such as Zuwuli ( LR @ ) , Xuehai ( SP @ ) , Yinlingquan ( SP @ ) and Sanyinjiao ( SP @ ) , etc. and the acupoints of yang meridians such as Biguan ( ST @ ) , Liangqiu ( ST @ ) and Yanglingquan ( GB @ ) , etc. were selected .", "sentence_id": 4}
+{"abstract_id": "24843962", "label": "methods", "text": "The reducing manipulation of respiratory reinforcing and reducing technique was applied to the acupoints of yin meridians and the reinforcing manipulation was applied to the acupoints of yang meridians .", "sentence_id": 5}
+{"abstract_id": "24843962", "label": "methods", "text": "The kinematics time parameters were determined and compared before and @ weeks after treatment .", "sentence_id": 6}
+{"abstract_id": "24843962", "label": "results", "text": "After treatment , the differences in the gait cycle , the phase time of standing ( % ) , the phase time of single support ( % ) , the phase time of unilateral sway ( % ) on the affected ( healthy ) foot and phase time of double support ( % ) were significant as compared with those before treatment in the patients of the two groups ( all P < @ ) , in which , the gait cycle ( @ + / - @ vs @ + / - @ ) , the phase time of standing ( % ) on the affected ( healthy ) foot -LSB- ( @ + / - @ ) % vs ( @ + / - @ ) % , ( @ + / - @ ) % vs ( @ + / - @ ) % -RSB- , the phase time of unilateral sway ( % ) on the affected ( healthy ) foot -LSB- ( @ + / - @ ) % vs ( @ + / - @ ) % , ( @ + / - @ ) % vs ( @ + / - @ ) % -RSB- and the phase time of double support ( % ) -LSB- ( @ + / - @ ) % vs ( @ + / - @ ) % -RSB- in the yin-yang needling group were improved much obviously after treatment as compared with those in the conventional acupuncture group .", "sentence_id": 7}
+{"abstract_id": "24843962", "label": "results", "text": "The differences in support phase time ( % ) , single support phase time ( % ) and sway phase time ( % ) were significant between the affected limb and healthy limb of the two groups after treatment ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24843962", "label": "conclusions", "text": "Yin-yang respiratory reinforcing and reducing needling technique effectively improves hemiplegic gait movement cycle and walking function in patients of ischemic stroke , which is superior to the conventional acupuncture treatment .", "sentence_id": 9}
+{"abstract_id": "25029875", "label": "objective", "text": "Biofeedback is a self-regulation therapy by which the patient learns how to optimize the functioning of his autonomic nervous system .", "sentence_id": 0}
+{"abstract_id": "25029875", "label": "objective", "text": "It has been applied to patients with various cardiovascular disorders .", "sentence_id": 1}
+{"abstract_id": "25029875", "label": "objective", "text": "The purpose of this study was to investigate the practical feasibility and the psychophysiological effects of biofeedback applied to heart rate variability ( HRV biofeedback ) in order to increase cardiac coherence in coronary artery disease ( CAD ) patients participating in a cardiac rehabilitation programme .", "sentence_id": 2}
+{"abstract_id": "25029875", "label": "results", "text": "In this randomised and controlled study , @ CAD patients were randomly assigned to an experimental or to a control group .", "sentence_id": 3}
+{"abstract_id": "25029875", "label": "results", "text": "The experimental group participated in a programme of @ sessions of cardiac coherence biofeedback training , in addition to the rehabilitation programme .", "sentence_id": 4}
+{"abstract_id": "25029875", "label": "results", "text": "The control group participated in the usual cardiac rehabilitation programme only .", "sentence_id": 5}
+{"abstract_id": "25029875", "label": "results", "text": "Physiological variables ( systolic and diastolic blood pressure , SDNN ) and psychosocial variables ( anxiety , depression , type D personality ) were measured at the start and at the end of the programme in both groups .", "sentence_id": 6}
+{"abstract_id": "25029875", "label": "results", "text": "Statistical comparisons assessed the inter and intra group differences .", "sentence_id": 7}
+{"abstract_id": "25029875", "label": "results", "text": "The small sample size precludes any firm conclusions concerning the effect of cardiac coherence biofeedback on physiological or psychological variables .", "sentence_id": 8}
+{"abstract_id": "25029875", "label": "results", "text": "However , we observed a significant increase of the percentage of cardiac coherence , in relation with an increased SDNN index .", "sentence_id": 9}
+{"abstract_id": "25029875", "label": "conclusions", "text": "Our study demonstrated the practical feasibility of cardiac coherence biofeedback training in CAD patients .", "sentence_id": 10}
+{"abstract_id": "25029875", "label": "conclusions", "text": "Further research is desirable to investigate the potential benefit of cardiac coherence biofeedback as an adjunct to stress management in cardiac rehabilitation .", "sentence_id": 11}
+{"abstract_id": "24885032", "label": "background", "text": "Each year approximately @ patients in the United Kingdom undergo surgery for esophagogastric cancer .", "sentence_id": 0}
+{"abstract_id": "24885032", "label": "background", "text": "Jejunostomy feeding tubes , placed at the time of surgery for early postoperative nutrition , have been shown to have a positive impact on clinical outcomes in the short term .", "sentence_id": 1}
+{"abstract_id": "24885032", "label": "background", "text": "Whether feeding out of hospital is of benefit is unknown .", "sentence_id": 2}
+{"abstract_id": "24885032", "label": "background", "text": "Local experience has identified that between @ and @ % of patients required ` rescue ' jejunostomy feeding for nutritional problems and weight loss while at home .", "sentence_id": 3}
+{"abstract_id": "24885032", "label": "background", "text": "This weight loss and poor nutrition may contribute to the detrimental effect on the overall quality of life ( QoL ) reported in these patients .", "sentence_id": 4}
+{"abstract_id": "24885032", "label": "methods", "text": "This randomized pilot and feasibility study will provide preliminary information on the routine use of jejunostomy feeding after hospital discharge in terms of clinical benefits and QoL .", "sentence_id": 5}
+{"abstract_id": "24885032", "label": "methods", "text": "Sixty participants undergoing esophagectomy or total gastrectomy will be randomized to receive either a planned program of six weeks of home jejunostomy feeding after discharge from hospital ( intervention ) or treatment-as-usual ( control ) .", "sentence_id": 6}
+{"abstract_id": "24885032", "label": "methods", "text": "The intention of this study is to inform a multi-centre randomized controlled trial .", "sentence_id": 7}
+{"abstract_id": "24885032", "label": "methods", "text": "The primary outcome measures will be recruitment and retention rates at six weeks and six months .", "sentence_id": 8}
+{"abstract_id": "24885032", "label": "methods", "text": "Secondary outcome measures will include disease specific and general QoL measures , nutritional parameters , total and oral nutritional intake , hospital readmission rates , and estimates of healthcare costs .", "sentence_id": 9}
+{"abstract_id": "24885032", "label": "methods", "text": "Up to @ participants will also be enrolled in a qualitative sub-study that will explore participants ' and carers ' experiences of home tube feeding.The results will be disseminated by presentation at surgical , gastroenterological and dietetic meetings and publication in appropriate peer review journals .", "sentence_id": 10}
+{"abstract_id": "24885032", "label": "methods", "text": "A patient-friendly lay summary will be made available on the University of Leicester and the University Hospitals of Leicester NHS Trust websites .", "sentence_id": 11}
+{"abstract_id": "24885032", "label": "methods", "text": "The study has full ethical and institutional approval and started recruitment in July @ .", "sentence_id": 12}
+{"abstract_id": "24615211", "label": "objective", "text": "To investigate whether the neural representations underlying alternating two acupoint combinations ( ACs ) are the same or not .", "sentence_id": 0}
+{"abstract_id": "24615211", "label": "methods", "text": "In this functional magnetic resonance imaging study , two sets of analgesia ACs were utilized , including Waiguan ( TE@ ) and Qiuxu ( GB@ ) for Group A , and Neiguan ( PC@ ) and Taichong ( LR@ ) for Group B , which are the most commonly adopted in clinical treatment .", "sentence_id": 1}
+{"abstract_id": "24615211", "label": "methods", "text": "Each group had @ healthy subjects .", "sentence_id": 2}
+{"abstract_id": "24615211", "label": "methods", "text": "An experimental design was proposed , which consisted of a pre-needling resting phase , a needling phase and a post-needling resting phase .", "sentence_id": 3}
+{"abstract_id": "24615211", "label": "methods", "text": "This paradigm optimally mimics the clinical protocol as well as focuses on both the stimulation and the resting periods .", "sentence_id": 4}
+{"abstract_id": "24615211", "label": "methods", "text": "The results were subjected to general linear model analysis , conjunction analysis and the functional connectivity analysis .", "sentence_id": 5}
+{"abstract_id": "24615211", "label": "results", "text": "The rostral anterior cingulated cortex was engaged in the initiative period of the acupuncture effect in both groups , and it was chosen as the seed region for the functional connectivity analysis for the following resting period .", "sentence_id": 6}
+{"abstract_id": "24615211", "label": "results", "text": "The results showed that several shared brain regions were involved in both groups , in particular the insula , amygdala and hypothalamus .", "sentence_id": 7}
+{"abstract_id": "24615211", "label": "results", "text": "Moreover , significant differences were located at the posterior cingulated cortex as revealed by a two sample - test ( P < @ , corrected ) .", "sentence_id": 8}
+{"abstract_id": "24615211", "label": "results", "text": "Other regions showed no significant differences .", "sentence_id": 9}
+{"abstract_id": "24615211", "label": "results", "text": "This finding was further supported by the spatial correlation analysis that the two groups were significantly correlated ( r = @ , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24615211", "label": "conclusions", "text": "This preliminary research helps us understand the neurophysiological mechanisms of acupuncture when following clinical guidelines on ACs , as well as provides an important opportunity to develop better treatment strategies for reducing , or even preventing pain .", "sentence_id": 11}
+{"abstract_id": "24502822", "label": "objective", "text": "To assess whether a dementia care coordination intervention delays time to transition from home and reduces unmet needs in elders with memory disorders .", "sentence_id": 0}
+{"abstract_id": "24502822", "label": "methods", "text": "@-month randomized controlled trial of @ community-living elders .", "sentence_id": 1}
+{"abstract_id": "24502822", "label": "methods", "text": "@ postal code areas of Baltimore , MD. .", "sentence_id": 2}
+{"abstract_id": "24502822", "label": "methods", "text": "Age @ + years , with a cognitive disorder , community-living , English-speaking , and having a study partner available .", "sentence_id": 3}
+{"abstract_id": "24502822", "label": "methods", "text": "@-month care coordination intervention to systematically identify and address dementia-related care needs through individualized care planning ; referral and linkage to services ; provision of dementia education and skill-building strategies ; and care monitoring by an interdisciplinary team .", "sentence_id": 4}
+{"abstract_id": "24502822", "label": "methods", "text": "Primary outcomes were time to transfer from home and total percent of unmet care needs at @months .", "sentence_id": 5}
+{"abstract_id": "24502822", "label": "results", "text": "Intervention participants had a significant delay in time to all-cause transition from home and the adjusted hazard of leaving the home was decreased by @ % ( Hazard ratio : @ , @ % Confidence Interval : @-@ @ ) compared with control participants .", "sentence_id": 6}
+{"abstract_id": "24502822", "label": "results", "text": "Although there was no significant group difference in reduction of total percent of unmet needs from baseline to @ months , the intervention group had significant reductions in the proportion of unmet needs in safety and legal/advance care domains relative to controls .", "sentence_id": 7}
+{"abstract_id": "24502822", "label": "results", "text": "Intervention participants had a significant improvement in self-reported quality of life ( QOL ) relative to control participants .", "sentence_id": 8}
+{"abstract_id": "24502822", "label": "results", "text": "No group differences were found in proxy-rated QOL , neuropsychiatric symptoms , or depression .", "sentence_id": 9}
+{"abstract_id": "24502822", "label": "conclusions", "text": "A home-based dementia care coordination intervention delivered by non-clinical community workers trained and overseen by geriatric clinicians led to delays in transition from home , reduced unmet needs , and improved self-reported QOL .", "sentence_id": 10}
+{"abstract_id": "24734247", "label": "objective", "text": "This study investigated long-term effects and implementation processes of workplace strength training for musculoskeletal disorders .", "sentence_id": 0}
+{"abstract_id": "24734247", "label": "methods", "text": "@ and @ laboratory technicians from private and public sector companies , respectively , replied to a @-year follow-up questionnaire subsequent to a @-year randomized controlled trial ( RCT ) with high-intensity strength training for prevention and treatment of neck , shoulder , and arm pain .", "sentence_id": 1}
+{"abstract_id": "24734247", "label": "methods", "text": "Being a natural experiment , the two participating companies implemented and modified the initial training program in different ways during the subsequent @ years after the RCT .", "sentence_id": 2}
+{"abstract_id": "24734247", "label": "results", "text": "At @-year follow-up the pain reduction in neck , shoulder , elbow , and wrist achieved during the first year was largely maintained at both companies .", "sentence_id": 3}
+{"abstract_id": "24734247", "label": "results", "text": "However , the private sector company was rated significantly better than the public sector company in ( @ ) training adherence , ( @ ) training culture , that is , relatively more employees trained at the workplace and with colleagues , ( @ ) self-reported health changes , and ( @ ) prevention of neck and wrist pain development among initially pain-free employees .", "sentence_id": 4}
+{"abstract_id": "24734247", "label": "conclusions", "text": "This natural experiment shows that strength training can be implemented successfully at different companies during working hours on a long-term basis with lasting effects on pain in neck , shoulder , and arm .", "sentence_id": 5}
+{"abstract_id": "24784698", "label": "background", "text": "This double-blind , randomized controlled trial aimed to investigate inhaled budesonide and oral dexamethasone compared with placebo for their prophylactic efficacy against acute mountain sickness after acute high-altitude exposure .", "sentence_id": 0}
+{"abstract_id": "24784698", "label": "methods", "text": "There were @ healthy young male lowland residents recruited and randomly assigned to receive inhaled budesonide ( @ g , twice a day -LSB- bid -RSB- ) , oral dexamethasone ( @ mg , bid ) , or placebo ( @ in each group ) .", "sentence_id": 1}
+{"abstract_id": "24784698", "label": "methods", "text": "They traveled to @ m altitude from @ m by car .", "sentence_id": 2}
+{"abstract_id": "24784698", "label": "methods", "text": "Medication started @ day before high-altitude exposure and continued until the third day of exposure .", "sentence_id": 3}
+{"abstract_id": "24784698", "label": "methods", "text": "Primary outcome measure was the incidence of acute mountain sickness after exposure .", "sentence_id": 4}
+{"abstract_id": "24784698", "label": "results", "text": "One hundred twenty-four subjects completed the study ( @ , @ , and @ in the budesonide , dexamethasone , and placebo groups , respectively ) .", "sentence_id": 5}
+{"abstract_id": "24784698", "label": "results", "text": "Demographic characteristics were comparable among the @ groups .", "sentence_id": 6}
+{"abstract_id": "24784698", "label": "results", "text": "After high-altitude exposure , significantly fewer participants in the budesonide ( @ % ) and dexamethasone ( @ % ) groups developed acute mountain sickness compared with participants receiving placebo ( @ % ) ( P = @ and P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24784698", "label": "results", "text": "Both the budesonide and dexamethasone groups had lower heart rate and higher pulse oxygen saturation ( SpO@ ) than the placebo group at altitude .", "sentence_id": 8}
+{"abstract_id": "24784698", "label": "results", "text": "Only the budesonide group demonstrated less deterioration in forced vital capacity and sleep quality than the placebo group .", "sentence_id": 9}
+{"abstract_id": "24784698", "label": "results", "text": "Four subjects in the dexamethasone group reported adverse reactions .", "sentence_id": 10}
+{"abstract_id": "24784698", "label": "conclusions", "text": "Both inhaled budesonide ( @ g , bid ) and oral dexamethasone ( @ mg , bid ) were effective for the prevention of acute mountain sickness , especially its severe form , compared with placebo .", "sentence_id": 11}
+{"abstract_id": "24784698", "label": "conclusions", "text": "Budesonide caused fewer adverse reactions than dexamethasone .", "sentence_id": 12}
+{"abstract_id": "24856229", "label": "objective", "text": "To evaluate heart rate variability ( HRV ) , hemodynamics , mechanics , dyspnea and blood gases following different mechanical ventilation ( MV ) settings .", "sentence_id": 0}
+{"abstract_id": "24856229", "label": "background", "text": "No study has evaluated physiological changes during T-piece trials following different MV settings .", "sentence_id": 1}
+{"abstract_id": "24856229", "label": "methods", "text": "In @ COPD patients on prolonged MV we applied in random order two MV settings : i ) pressure support ( PS ) @ cm H@O + positive end-expiratory pressure ( PEEP ) @ cm H@O ( setting-@ ) and ii ) PS @ cm H@O + PEEP @ cm H@O ( setting-@ ) , each followed by a @ min T-piece trial .", "sentence_id": 2}
+{"abstract_id": "24856229", "label": "results", "text": "Setting-@ induced greater minute ventilation , tidal volume/inspiratory time and lower pulmonary artery occlusion pressure ; setting-@ reduced intrinsic PEEP .", "sentence_id": 3}
+{"abstract_id": "24856229", "label": "results", "text": "Mechanics and hemodynamics data did not differ , but all HRV time domain indices were reduced only after setting-@ , suggesting a decreased parasympathetic and increased sympathetic cardiac modulation .", "sentence_id": 4}
+{"abstract_id": "24856229", "label": "conclusions", "text": "The T-piece trial following setting-@ seems less stressful on neural control of HRV .", "sentence_id": 5}
+{"abstract_id": "24856229", "label": "conclusions", "text": "Future studies on T-piece trials should consider the residual effect of the MV setting .", "sentence_id": 6}
+{"abstract_id": "25213578", "label": "background", "text": "There is a gap in the literature regarding learning outcomes linked to the use of high-fidelity simulators compared to that of traditional teaching methods .", "sentence_id": 0}
+{"abstract_id": "25213578", "label": "objective", "text": "To examine the effect of using high-fidelity simulators on knowledge and skills acquisition and retention with university students .", "sentence_id": 1}
+{"abstract_id": "25213578", "label": "methods", "text": "A randomized two-arm trial using two different educational approaches on @ nursing students assigned randomly to two groups was used at two points of time .", "sentence_id": 2}
+{"abstract_id": "25213578", "label": "results", "text": "The results showed significant differences in favor of the participants in the high-fidelity simulator group on both the acquisition and retention of knowledge and skills over time .", "sentence_id": 3}
+{"abstract_id": "25213578", "label": "results", "text": "However , a significant loss of cardiopulmonary resuscitation knowledge and skills occurred at @ months after training in both groups .", "sentence_id": 4}
+{"abstract_id": "25213578", "label": "conclusions", "text": "The findings of this study may assist educators in integrating high-fidelity simulators in education and training .", "sentence_id": 5}
+{"abstract_id": "25213578", "label": "conclusions", "text": "In addition , the findings may help nursing educators to arrange additional cardiopulmonary resuscitation training sessions in order to improve cardiac arrested patients ' outcomes .", "sentence_id": 6}
+{"abstract_id": "25213578", "label": "conclusions", "text": "High-fidelity simulation ( HFS ) provides students with interactive learning experiences in a safe controlled environment .", "sentence_id": 7}
+{"abstract_id": "25213578", "label": "conclusions", "text": "HFS enables teachers to implement critical clinical scenarios , such as cardiac arrest , without risk to patients .", "sentence_id": 8}
+{"abstract_id": "25213578", "label": "conclusions", "text": "Integrating the simulation training into nursing curricula will help to overcome the challenges that face many courses , specifically the shortage of clinical areas for training and the increase in numbers of nursing students .", "sentence_id": 9}
+{"abstract_id": "25048383", "label": "objective", "text": "To evaluate weekly subcutaneous albiglutide versus daily sitagliptin in renally impaired patients with type @ diabetes and inadequately controlled glycemia on a regimen of diet and exercise and/or oral antihyperglycemic medications .", "sentence_id": 0}
+{"abstract_id": "25048383", "label": "methods", "text": "In this phase III , randomized , double-blind , multicenter , @-week study , the primary study end point was HbA@c change from baseline at week @ in patients with renal impairment , as assessed with estimated glomerular filtration rate and categorized as mild , moderate , or severe ( @ to @ , @ to @ , and @ to @ mL/min/@ @ m ( @ ) , respectively ) .", "sentence_id": 1}
+{"abstract_id": "25048383", "label": "methods", "text": "Secondary end points included fasting plasma glucose ( FPG ) , weight , achievement of treatment targets , hyperglycemic rescue , and safety .", "sentence_id": 2}
+{"abstract_id": "25048383", "label": "results", "text": "Baseline demographics were similar across treatment and renal impairment groups with overall mean age of @ years , BMI of @ kg/m ( @ ) , HbA@c of @ % ( @ mmol/mol ) , and diabetes disease duration of @ years .", "sentence_id": 3}
+{"abstract_id": "25048383", "label": "results", "text": "HbA@c change from baseline at week @ was significantly greater for albiglutide than sitagliptin ( -@ % vs. -@ % , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25048383", "label": "results", "text": "Decreases in HbA@c , FPG , and weight were seen through week @ .", "sentence_id": 5}
+{"abstract_id": "25048383", "label": "results", "text": "Time to hyperglycemic rescue through week @ was significantly longer for albiglutide than sitagliptin ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25048383", "label": "results", "text": "Results of safety assessments were similar between groups , and most adverse events ( AEs ) were mild or moderate .", "sentence_id": 7}
+{"abstract_id": "25048383", "label": "results", "text": "The incidences of gastrointestinal AEs for albiglutide and sitagliptin were as follows : overall , @ % , @ % ; diarrhea , @ % , @ % ; nausea , @ % , @ % ; and vomiting , @ % , @ % , respectively .", "sentence_id": 8}
+{"abstract_id": "25048383", "label": "conclusions", "text": "Once-weekly albiglutide therapy in renally impaired patients with type @ diabetes provided statistically superior glycemic improvement with almost similar tolerability compared with daily sitagliptin therapy .", "sentence_id": 9}
+{"abstract_id": "25014057", "label": "background", "text": "Antihypertensive drugs are used to control blood pressure ( BP ) and reduce macro - and microvascular complications in hypertensive patients with diabetes .", "sentence_id": 0}
+{"abstract_id": "25014057", "label": "objective", "text": "The present study aimed to compare the functional vascular changes in hypertensive patients with type @ diabetes mellitus after @ weeks of treatment with amlodipine or losartan .", "sentence_id": 1}
+{"abstract_id": "25014057", "label": "methods", "text": "Patients with a previous diagnosis of hypertension and type @ diabetes mellitus were randomly divided into @ groups and evaluated after @ weeks of treatment with amlodipine ( @ mg/day ) or losartan ( @ mg/day ) .", "sentence_id": 2}
+{"abstract_id": "25014057", "label": "methods", "text": "Patient evaluation included BP measurement , ambulatory BP monitoring , and assessment of vascular parameters using applanation tonometry , pulse wave velocity ( PWV ) , and flow-mediated dilation ( FMD ) of the brachial artery .", "sentence_id": 3}
+{"abstract_id": "25014057", "label": "results", "text": "A total of @ patients were evaluated ( @ in each group ) , with a predominance of women ( @ % ) in both groups .", "sentence_id": 4}
+{"abstract_id": "25014057", "label": "results", "text": "The mean age of the patients in both groups was similar ( amlodipine group : @ @ years ; losartan group : @ @ years ) , with no significant difference in the mean BP -LSB- amlodipine group : @ @ mmHg ( systolic ) and @ @ mmHg ( diastolic ) ; losartan group : @ @ mmHg ( systolic ) and @ @ mmHg ( diastolic ) -RSB- .", "sentence_id": 5}
+{"abstract_id": "25014057", "label": "results", "text": "The augmentation index ( @ % @ % and @ % @ % , p = @ ) and augmentation pressure ( @ @ mmHg and @ @ mmHg , p = @ ) were lower in the amlodipine group when compared with the losartan group .", "sentence_id": 6}
+{"abstract_id": "25014057", "label": "results", "text": "PWV and FMD were similar in both groups .", "sentence_id": 7}
+{"abstract_id": "25014057", "label": "conclusions", "text": "Hypertensive patients with type @ diabetes mellitus treated with amlodipine exhibited an improved pattern of pulse wave reflection in comparison with those treated with losartan .", "sentence_id": 8}
+{"abstract_id": "25014057", "label": "conclusions", "text": "However , the use of losartan may be associated with independent vascular reactivity to the pressor effect .", "sentence_id": 9}
+{"abstract_id": "25246774", "label": "objective", "text": "The objective of the current study was to evaluate the efficacy of aminaphtone to control gum bleeding .", "sentence_id": 0}
+{"abstract_id": "25246774", "label": "methods", "text": "Fifteen male and @ female children , aged between @ and @ years with a mean age of @ years and with gingival bleeding , were enrolled in this randomized , double-blind , placebo-controlled , Phase IV clinical trial .", "sentence_id": 1}
+{"abstract_id": "25246774", "label": "methods", "text": "The inclusion criterion was gingivitis with gingival bleeding .", "sentence_id": 2}
+{"abstract_id": "25246774", "label": "methods", "text": "Participants were prescribed either aminaphtone or placebo .", "sentence_id": 3}
+{"abstract_id": "25246774", "label": "methods", "text": "Thirty identical boxes containing blister packs of identical pills of either aminaphtone or placebo were produced and coded with unique numbers by the manufacturer ( Baldacci Laboratory , Brazil ) and donated for this trial .", "sentence_id": 4}
+{"abstract_id": "25246774", "label": "methods", "text": "A research assistant administered aminaphtone ( Capilarema @ mg ) to fifteen patients or placebo to fifteen patients twice daily for @ days .", "sentence_id": 5}
+{"abstract_id": "25246774", "label": "methods", "text": "Intraoral clinical evaluations of bleeding were made before starting medication/placebo and then at @ and @ days after administration .", "sentence_id": 6}
+{"abstract_id": "25246774", "label": "results", "text": "On comparing the number of bleeding points before and after treatment between the aminaphtone and placebo groups , we found significantly higher reductions with the medication ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25246774", "label": "conclusions", "text": "Aminaphtone reduces gum bleeding in gingivitis , and may have a supportive role in the control of bleeding .", "sentence_id": 8}
+{"abstract_id": "24876260", "label": "objective", "text": "Magnetic resonance perfusion ( MRP ) and computed tomographic perfusion ( CTP ) are being increasingly applied in acute stroke trials and clinical practice , yet the comparability of their perfusion values is not well validated .", "sentence_id": 0}
+{"abstract_id": "24876260", "label": "objective", "text": "The aim of this study was to validate the comparability of CTP and MRP measures .", "sentence_id": 1}
+{"abstract_id": "24876260", "label": "methods", "text": "A @-step approach was used .", "sentence_id": 2}
+{"abstract_id": "24876260", "label": "methods", "text": "Step @ was a derivation step , where we analyzed @ patients with acute ischemic stroke who had both CTP and MRP performed within @ hours of each other and within @ hours of stroke onset .", "sentence_id": 3}
+{"abstract_id": "24876260", "label": "methods", "text": "In this step , we derived the optimal perfusion map with the least difference between MRP and CTP .", "sentence_id": 4}
+{"abstract_id": "24876260", "label": "methods", "text": "In step @ , the optimal map was validated on whole-brain perfusion data of @ patients .", "sentence_id": 5}
+{"abstract_id": "24876260", "label": "methods", "text": "Step @ was to apply the optimal perfusion map to define cross-modality reperfusion from acute CTP to @-hour MRP in @ patients and , in turn , to assess how accurately this predicted @-month clinical outcome .", "sentence_id": 6}
+{"abstract_id": "24876260", "label": "results", "text": "Among @ different perfusion maps included in this study , time to peak of the residual function ( T ( max ) ) was the only one with a nonsignificant difference between CTP and MRP in delineating perfusion defects .", "sentence_id": 7}
+{"abstract_id": "24876260", "label": "results", "text": "This was validated on whole-brain perfusion data , showing high concordance of T ( max ) between the @ modalities ( concordance correlation coefficient of Lin , > @ ) ; the best concordance was at @ s.", "sentence_id": 8}
+{"abstract_id": "24876260", "label": "results", "text": "At T ( max ) > @ s threshold , MRP and CTP reached substantial agreement in mismatch classification ( > @ ) .", "sentence_id": 9}
+{"abstract_id": "24876260", "label": "results", "text": "Cross-modality reperfusion calculated by T ( max ) > @ s strongly predicted good functional outcome at @ months ( area under the curve , @ ; P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24876260", "label": "conclusions", "text": "MRP and CTP can be used interchangeably if one uses T ( max ) measurement .", "sentence_id": 11}
+{"abstract_id": "24693681", "label": "background", "text": "Previous studies have demonstrated that oxidative stress by mediating the excessive production of reactive oxygen species is involved in tissue damage and organ failure during and after surgery .", "sentence_id": 0}
+{"abstract_id": "24693681", "label": "background", "text": "The impact of the preoperative immunonutrition including antioxidants on the postoperative course of patients undergoing hepatic surgery was investigated in this pilot study .", "sentence_id": 1}
+{"abstract_id": "24693681", "label": "methods", "text": "Twenty-three living donor liver transplantation ( LDLT ) donors were randomly assigned to either an experimental ( AO ) group , received a commercial supplement enriched with antioxidant nutrients for each of the @ days immediately prior to surgery while maintaining normal food intake , or a control ( CT ) group , administered no supplement .", "sentence_id": 2}
+{"abstract_id": "24693681", "label": "methods", "text": "Antioxidative capacity was measured by spectrophotometry of patient serum using a free-radical analytical system .", "sentence_id": 3}
+{"abstract_id": "24693681", "label": "results", "text": "The antioxidative capacity of @ % patients in the AO group increased after immunonutrition .", "sentence_id": 4}
+{"abstract_id": "24693681", "label": "results", "text": "Compared to the CT group , the AO group was found to have higher antioxidant capacity and transferrin levels ; lower WBC , lymphocyte , and neutrophil counts ; and briefer duration of postoperative fever during the postsurgical period .", "sentence_id": 5}
+{"abstract_id": "24693681", "label": "results", "text": "No significant differences were found between the @ groups regarding the nutritional parameters ; liver functioning parameters ; immunological parameters ; intraoperative factors ; postoperative outcomes .", "sentence_id": 6}
+{"abstract_id": "24693681", "label": "conclusions", "text": "Preoperative immunonutrition including antioxidants might play a beneficial role in improving postsurgical immunological response but the modest biological advantage was not associated with any significant clinical outcome .", "sentence_id": 7}
+{"abstract_id": "26227188", "label": "background", "text": "The RITA-@ ( Third Randomised Intervention Treatment of Angina ) trial compared outcomes of a routine early invasive strategy ( coronary arteriography and myocardial revascularization , as clinically indicated ) to those of a selective invasive strategy ( coronary arteriography for recurrent ischemia only ) in patients with non-ST-segment elevation acute coronary syndrome ( NSTEACS ) .", "sentence_id": 0}
+{"abstract_id": "26227188", "label": "background", "text": "At a median of @ years ' follow-up , the routine invasive strategy was associated with a @ % reduction in the odds of all-cause mortality .", "sentence_id": 1}
+{"abstract_id": "26227188", "label": "objective", "text": "This study reports @-year follow-up outcomes of the randomized cohort to determine the impact of a routine invasive strategy on longer-term mortality .", "sentence_id": 2}
+{"abstract_id": "26227188", "label": "methods", "text": "We randomized @,@ patients with NSTEACS to receive routine invasive or selective invasive strategies .", "sentence_id": 3}
+{"abstract_id": "26227188", "label": "methods", "text": "All randomized patients had annual follow-up visits up to @ years , and mortality was documented thereafter using data from the Office of National Statistics .", "sentence_id": 4}
+{"abstract_id": "26227188", "label": "results", "text": "Over @ years , there were no differences in mortality between the @ groups ( all-cause deaths in @ -LSB- @ % -RSB- vs. @ patients -LSB- @ % -RSB- : p = @ ; and cardiovascular deaths in @ -LSB- @ % -RSB- vs. @ patients -LSB- @ % -RSB- : p = @ in the routine invasive and selective invasive groups , respectively ) .", "sentence_id": 5}
+{"abstract_id": "26227188", "label": "results", "text": "Multivariate analysis identified several independent predictors of @-year mortality : age , previous myocardial infarction , heart failure , smoking status , diabetes , heart rate , and ST-segment depression .", "sentence_id": 6}
+{"abstract_id": "26227188", "label": "results", "text": "A modified post-discharge Global Registry of Acute Coronary Events ( GRACE ) score was used to calculate an individual risk score for each patient and to form low-risk , medium-risk , and high-risk groups .", "sentence_id": 7}
+{"abstract_id": "26227188", "label": "results", "text": "Risk of death within @ years varied markedly from @ % in the low-risk group to @ % in the high-risk group .", "sentence_id": 8}
+{"abstract_id": "26227188", "label": "results", "text": "This mortality trend did not depend on the assigned treatment strategy .", "sentence_id": 9}
+{"abstract_id": "26227188", "label": "conclusions", "text": "The advantage of reduced mortality of routine early invasive strategy seen at @ years was attenuated during later follow-up , with no evidence of a difference in outcome at @ years .", "sentence_id": 10}
+{"abstract_id": "26227188", "label": "conclusions", "text": "Further trials of contemporary intervention strategies in patients with NSTEACS are warranted .", "sentence_id": 11}
+{"abstract_id": "26227188", "label": "conclusions", "text": "( Third Randomised Intervention Treatment of Angina trial -LSB- RITA-@ -RSB- ; ISRCTN@ ) .", "sentence_id": 12}
+{"abstract_id": "24302090", "label": "objective", "text": "Communication about end-of-life care is a core clinical skill .", "sentence_id": 0}
+{"abstract_id": "24302090", "label": "objective", "text": "Simulation-based training improves skill acquisition , but effects on patient-reported outcomes are unknown .", "sentence_id": 1}
+{"abstract_id": "24302090", "label": "objective", "text": "To assess the effects of a communication skills intervention for internal medicine and nurse practitioner trainees on patient - and family-reported outcomes .", "sentence_id": 2}
+{"abstract_id": "24302090", "label": "methods", "text": "Randomized trial conducted with @ internal medicine and @ nurse practitioner trainees between @ and @ at the University of Washington and Medical University of South Carolina .", "sentence_id": 3}
+{"abstract_id": "24302090", "label": "methods", "text": "Participants were randomized to an @-session , simulation-based , communication skills intervention ( N = @ ) or usual education ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "24302090", "label": "methods", "text": "Primary outcome was patient-reported quality of communication ( QOC ; mean rating of @ items rated from @-@ , with @ = poor and @ = perfect ) .", "sentence_id": 5}
+{"abstract_id": "24302090", "label": "methods", "text": "Secondary outcomes were patient-reported quality of end-of-life care ( QEOLC ; mean rating of @ items rated from @-@ ) and depressive symptoms ( assessed using the @-item Personal Health Questionnaire -LSB- PHQ-@ -RSB- ; range , @-@ , higher scores worse ) and family-reported QOC and QEOLC .", "sentence_id": 6}
+{"abstract_id": "24302090", "label": "methods", "text": "Analyses were clustered by trainee .", "sentence_id": 7}
+{"abstract_id": "24302090", "label": "results", "text": "There were @ patient ratings ( @ % response ) and @ family ratings ( @ % response ) .", "sentence_id": 8}
+{"abstract_id": "24302090", "label": "results", "text": "The intervention was not associated with significant changes in QOC or QEOLC .", "sentence_id": 9}
+{"abstract_id": "24302090", "label": "results", "text": "Mean values for postintervention patient QOC and QEOLC were @ ( @ % CI , @ to @ ) and @ ( @ % CI , @ to @ ) respectively , compared with @ ( @ % CI , @ to @ ) and @ ( @ % CI , @ to @ ) for control conditions .", "sentence_id": 10}
+{"abstract_id": "24302090", "label": "results", "text": "After adjustment , comparing intervention with control , there was no significant difference in the QOC score for patients ( difference , @ points -LSB- @ % CI , -@ to @ -RSB- ; P = @ ) or families ( difference , @ -LSB- @ % CI , -@ to @ -RSB- ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24302090", "label": "results", "text": "There was no significant difference in QEOLC score for patients ( difference , @ points -LSB- @ % CI , -@ to @ -RSB- ; P = @ ) or families ( difference , @ -LSB- @ % CI , -@ to @ -RSB- ; P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24302090", "label": "results", "text": "The intervention was associated with significantly increased depression scores among patients of postintervention trainees ( mean score , @ -LSB- @ % CI , @ to @ -RSB- , compared with @ -LSB- @ % CI , @ to @ -RSB- ) for control conditions ; adjusted model showed an intervention effect of @ ( @ % CI , @ to @ ; P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24302090", "label": "conclusions", "text": "Among internal medicine and nurse practitioner trainees , simulation-based communication training compared with usual education did not improve quality of communication about end-of-life care or quality of end-of-life care but was associated with a small increase in patients ' depressive symptoms .", "sentence_id": 14}
+{"abstract_id": "24302090", "label": "conclusions", "text": "These findings raise questions about skills transfer from simulation training to actual patient care and the adequacy of communication skills assessment .", "sentence_id": 15}
+{"abstract_id": "25050589", "label": "objective", "text": "NSAIDs , such as diclofenac , are the most commonly used medications to treat osteoarthritis ( OA ) , but they are associated with dose-related adverse events ( AEs ) .", "sentence_id": 0}
+{"abstract_id": "25050589", "label": "objective", "text": "Low-dose submicron diclofenac was developed using a new , proprietary dry milling process that creates submicron drug particles ( SoluMatrix Fine Particle Technology * ) , enabling effective treatment at lower doses than other commercially available diclofenac drug products .", "sentence_id": 1}
+{"abstract_id": "25050589", "label": "objective", "text": "This phase @ study evaluated the efficacy and safety of low-dose submicron diclofenac @mg three times daily ( tid ) and twice daily ( bid ) in patients with OA pain .", "sentence_id": 2}
+{"abstract_id": "25050589", "label": "methods", "text": "This double-blind study enrolled patients @ years of age with clinically and radiographically confirmed ( Kellgren-Lawrence grade II-III ) hip or knee OA .", "sentence_id": 3}
+{"abstract_id": "25050589", "label": "methods", "text": "Eligible patients were chronic NSAID and/or acetaminophen ( APAP ) users with baseline Western Ontario and McMasters Universities Osteoarthritis Index ( WOMAC ) pain subscale scores @mm by visual analog scale and an OA flare ( @mm increase in WOMAC pain subscale score following discontinuation of NSAIDs/APAP at screening ) .", "sentence_id": 4}
+{"abstract_id": "25050589", "label": "methods", "text": "Patients were randomized to submicron diclofenac @mg tid , submicron diclofenac @mg bid , or placebo for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25050589", "label": "methods", "text": "ClinicalTrials.gov identifier : NCT@ .", "sentence_id": 6}
+{"abstract_id": "25050589", "label": "methods", "text": "Efficacy parameters included mean change from baseline in WOMAC pain subscale score at week @ ( primary efficacy parameter ) and in average total WOMAC score over @ weeks .", "sentence_id": 7}
+{"abstract_id": "25050589", "label": "results", "text": "Submicron diclofenac @mg tid significantly improved WOMAC pain subscale scores from baseline at @ weeks ( -@ ; p = @ ) compared with placebo ( -@ ) .", "sentence_id": 8}
+{"abstract_id": "25050589", "label": "results", "text": "Submicron diclofenac @mg bid provided numerical improvement in pain at week @ that did not reach statistical significance ( -@ ; p = @ ) compared with placebo .", "sentence_id": 9}
+{"abstract_id": "25050589", "label": "results", "text": "Submicron diclofenac @mg tid ( -@ ; p = @ ) and @mg bid ( -@ ; p = @ ) improved the average total WOMAC score in treated patients over @ weeks compared with placebo ( -@ ) .", "sentence_id": 10}
+{"abstract_id": "25050589", "label": "results", "text": "The most frequent AEs in the submicron diclofenac-treated groups were diarrhea , headache , nausea , and constipation .", "sentence_id": 11}
+{"abstract_id": "25050589", "label": "results", "text": "The inclusion of patients with a documented requirement for analgesic therapy ( OA ` flare ' ) at baseline and the high rates of rescue medication usage in the placebo group may have impacted the study outcome for the submicron diclofenac treatment groups .", "sentence_id": 12}
+{"abstract_id": "25050589", "label": "conclusions", "text": "Low-dose submicron diclofenac is an effective therapeutic option for the treatment of OA pain .", "sentence_id": 13}
+{"abstract_id": "24684973", "label": "objective", "text": "The phase @ TRANSFORMS and FREEDOMS studies established the efficacy of fingolimod in reducing multiple sclerosis ( MS ) relapses and magnetic resonance imaging lesions compared with intramuscular ( IM ) interferon ( IFN ) -@ a and placebo over @ and @ months , respectively .", "sentence_id": 0}
+{"abstract_id": "24684973", "label": "methods", "text": "To investigate the efficacy of fingolimod at the approved @ mg dose in patients early in the MS disease course , post hoc subgroup analyses of TRANSFORMS ( n = @ ) and FREEDOMS ( n = @ ) data were conducted in patients who experienced their first MS symptom < @ years before randomization .", "sentence_id": 1}
+{"abstract_id": "24684973", "label": "results", "text": "Fingolimod @ mg reduced annualized relapse rate by @ % ( P = @ ) versus IFN-@a IM and by @ % ( P < @ ) versus placebo in patients with < @ years since first symptom ; respective reductions were @ % and @ % in subgroups of patients with @ years since first symptom .", "sentence_id": 2}
+{"abstract_id": "24684973", "label": "results", "text": "For patients with < @ years since their first symptom , significantly fewer new/newly enlarged T@ lesions were observed with fingolimod versus IFN-@a IM ( mean number , @ vs. @ ; P = @ ) or placebo ( @ vs. @ ; P < @ ) ; the mean number of gadolinium-enhancing T@ lesions was significantly reduced versus placebo ( @ vs. @ ; P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24684973", "label": "conclusions", "text": "Fingolimod @ mg is highly effective in reducing relapses and MRI activity in patients early in the MS disease course .", "sentence_id": 4}
+{"abstract_id": "24763755", "label": "objective", "text": "Scarring from bacterial keratitis remains a leading cause of visual loss .", "sentence_id": 0}
+{"abstract_id": "24763755", "label": "objective", "text": "To determine whether topical corticosteroids are beneficial as an adjunctive therapy for bacterial keratitis if given early in the course of infection .", "sentence_id": 1}
+{"abstract_id": "24763755", "label": "methods", "text": "The Steroids for Corneal Ulcers Trial ( SCUT ) was a randomized , double-masked , placebo-controlled trial that overall found no effect of adding topical corticosteroids to topical moxifloxacin hydrochloride in bacterial keratitis .", "sentence_id": 2}
+{"abstract_id": "24763755", "label": "methods", "text": "Here , we assess the timing of administration of corticosteroids in a subgroup analysis of the SCUT .", "sentence_id": 3}
+{"abstract_id": "24763755", "label": "methods", "text": "We define earlier administration of corticosteroids ( vs placebo ) as addition after @ to @ days of topical antibiotics and later as addition after @ or more days of topical antibiotics .", "sentence_id": 4}
+{"abstract_id": "24763755", "label": "methods", "text": "We assess the effect of topical corticosteroids ( vs placebo ) on @-month best spectacle-corrected visual acuity in patients who received corticosteroids or placebo earlier vs later .", "sentence_id": 5}
+{"abstract_id": "24763755", "label": "methods", "text": "Further analyses were performed for subgroups of patients with non-Nocardia keratitis and those with no topical antibiotic use before enrollment .", "sentence_id": 6}
+{"abstract_id": "24763755", "label": "results", "text": "Patients treated with topical corticosteroids as adjunctive therapy within @ to @ days of antibiotic therapy had approximately @-line better visual acuity at @ months than did those given placebo ( -@ logMAR ; @ % CI , -@ to -@ logMAR ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24763755", "label": "results", "text": "In patients who had @ or more days of antibiotic therapy before corticosteroid treatment , the effect was not significant ; patients given corticosteroids had @-line worse visual acuity at @ months compared with those in the placebo group ( @ logMAR ; @ % CI , -@ to @ logMAR ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24763755", "label": "results", "text": "Patients with non-Nocardia keratitis and those having no topical antibiotic use before the SCUT enrollment showed significant improvement in best spectacle-corrected visual acuity at @ months if corticosteroids were administered earlier rather than later .", "sentence_id": 9}
+{"abstract_id": "24763755", "label": "conclusions", "text": "There may be a benefit with adjunctive topical corticosteroids if application occurs earlier in the course of bacterial corneal ulcers .", "sentence_id": 10}
+{"abstract_id": "24367678", "label": "objective", "text": "We used data from a randomized trial of HIV-tuberculosis co-infected patients in Mozambique to determine the incidence and predictors of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome ( IRIS ) occurring within @ weeks of starting antiretroviral therapy , and to evaluate its association with patient outcome at @ weeks .", "sentence_id": 0}
+{"abstract_id": "24367678", "label": "methods", "text": "HIV-tuberculosis co-infected and antiretroviral therapy-nave adults with less than @ CD@/mm@ were randomized to a nevirapine or efavirenz-based antiretroviral therapy initiated @ to @ weeks after starting tuberculosis treatment , and were then followed for @ weeks .", "sentence_id": 1}
+{"abstract_id": "24367678", "label": "methods", "text": "Tuberculosis cases were diagnosed using WHO guidelines , and tuberculosis-IRIS by case definitions of the International Network for the Study of HIV-associated IRIS .", "sentence_id": 2}
+{"abstract_id": "24367678", "label": "results", "text": "The @ HIV-tuberculosis co-infected patients who initiated antiretroviral therapy had a median CD@ count of @ cells/mm ( @ ) and HIV-@ RNA of @ log@ copies/mL .", "sentence_id": 3}
+{"abstract_id": "24367678", "label": "results", "text": "Mortality at week @ was @ % ( @/@ ) .", "sentence_id": 4}
+{"abstract_id": "24367678", "label": "results", "text": "Fifty-three ( @ % ) patients presented a tuberculosis-IRIS within @ weeks of starting antiretroviral therapy .", "sentence_id": 5}
+{"abstract_id": "24367678", "label": "results", "text": "Being female and having a low CD@ count , high HIV-@ RNA load , low body mass index and smear-positive pulmonary tuberculosis were independently associated with tuberculosis-IRIS .", "sentence_id": 6}
+{"abstract_id": "24367678", "label": "results", "text": "After adjustment for baseline body mass index , CD@ count and hemoglobin , occurrence of tuberculosis-IRIS was independently associated with @-week mortality ( aOR @ @ % CI @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24367678", "label": "results", "text": "Immunological and HIV-@ virological responses and tuberculosis treatment outcomes were not different between patients with and without tuberculosis-IRIS .", "sentence_id": 8}
+{"abstract_id": "24367678", "label": "conclusions", "text": "In this large prospective cohort , tuberculosis-IRIS occurrence within @ weeks of starting antiretroviral therapy was independently associated with the mortality of HIV-tuberculosis co-infected patients at @ weeks post antiretroviral therapy initiation .", "sentence_id": 9}
+{"abstract_id": "25214516", "label": "background", "text": "Rifaximin , a nonabsorbable antibiotic that decreases lipopolysaccharide ( LPS ) in cirrhotics , may decrease the elevated levels of microbial translocation , T-cell activation and inflammation in human immunodeficiency virus ( HIV ) - positive immune nonresponders to antiretroviral therapy ( ART ) .", "sentence_id": 0}
+{"abstract_id": "25214516", "label": "methods", "text": "HIV-positive adults receiving ART for @ weeks with undetectable viremia for @ weeks and CD@ ( + ) T-cell counts < @ cells/mm ( @ ) were randomized @:@ to rifaximin versus no study treatment for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25214516", "label": "methods", "text": "T-cell activation , LPS , and soluble CD@ were measured at baseline and at weeks @ , @ , and @ .", "sentence_id": 2}
+{"abstract_id": "25214516", "label": "methods", "text": "Wilcoxon rank sum tests compared changes between arms .", "sentence_id": 3}
+{"abstract_id": "25214516", "label": "results", "text": "Compared with no study treatment ( n = @ ) , rifaximin ( n = @ ) use was associated with a significant difference between study arms in the change from baseline to week @ for CD@ ( + ) T-cell activation ( median change , @ % with rifaximin vs +@ % with no treatment ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25214516", "label": "results", "text": "This difference was driven by an increase in the no-study-treatment arm because there was no significant change within the rifaximin arm .", "sentence_id": 5}
+{"abstract_id": "25214516", "label": "results", "text": "Similarly , although there were significant differences between study arms in change from baseline to week @ for LPS and soluble CD@ , there were no significant changes within the rifaximin arm .", "sentence_id": 6}
+{"abstract_id": "25214516", "label": "conclusions", "text": "In immune nonresponders to ART , rifaximin minimally affected microbial translocation and CD@ ( + ) T-cell activation .", "sentence_id": 7}
+{"abstract_id": "25214516", "label": "conclusions", "text": "Trial registration number.NCT@ .", "sentence_id": 8}
+{"abstract_id": "24393747", "label": "background", "text": "Canagliflozin , a sodium glucose co-transporter @ inhibitor , lowers plasma glucose in individuals with hyperglycemia by inhibiting renal glucose reabsorption and increasing glucosuria .", "sentence_id": 0}
+{"abstract_id": "24393747", "label": "background", "text": "Urinary tract infections ( UTIs ) were characterized in patients with type @ diabetes mellitus enrolled in Phase III studies of canagliflozin .", "sentence_id": 1}
+{"abstract_id": "24393747", "label": "methods", "text": "Analyses were performed in @ pooled datasets : Population @ ( N = @ ; mean exposure -LSB- weeks -RSB- : canagliflozin , @ ; placebo , @ ) including patients from @ placebo-controlled studies ; Population @ ( N = @ ; mean exposure -LSB- weeks -RSB- : canagliflozin , @ ; control , @ ) including patients from @ placebo - and active-controlled studies ( including patients with renal impairment or high risk of cardiovascular disease , and older patients ) .", "sentence_id": 2}
+{"abstract_id": "24393747", "label": "methods", "text": "Individual studies in special patient populations and @ active-controlled studies were analyzed separately .", "sentence_id": 3}
+{"abstract_id": "24393747", "label": "methods", "text": "Patients with a prior history of UTIs were not excluded from these studies .", "sentence_id": 4}
+{"abstract_id": "24393747", "label": "methods", "text": "Urinary tract infection frequency and characteristics were systematically collected , with additional information for each event collected using supplemental electronic case report forms .", "sentence_id": 5}
+{"abstract_id": "24393747", "label": "results", "text": "In Populations @ and @ , canagliflozin @ and @ mg were associated with small increases in the incidence of UTIs compared with control , with no dose-dependence .", "sentence_id": 6}
+{"abstract_id": "24393747", "label": "results", "text": "Urinary tract infections with canagliflozin were similar to those with control in severity , and upper UTIs were infrequent across groups .", "sentence_id": 7}
+{"abstract_id": "24393747", "label": "results", "text": "No increase in serious events or those leading to discontinuation were seen with canagliflozin versus control .", "sentence_id": 8}
+{"abstract_id": "24393747", "label": "results", "text": "Time to the first occurrence of symptomatic UTIs tended to be earlier with canagliflozin than placebo in Population @ , and similar with canagliflozin and control in Population @ ; median duration of events was similar across groups in both populations .", "sentence_id": 9}
+{"abstract_id": "24393747", "label": "results", "text": "The proportion of patients with recurrent events was low across groups .", "sentence_id": 10}
+{"abstract_id": "24393747", "label": "conclusions", "text": "Canagliflozin was associated with a small increase in incidence of UTIs in patients with type @ diabetes mellitus , with no increase in serious or upper UTIs .", "sentence_id": 11}
+{"abstract_id": "24571704", "label": "objective", "text": "To compare the erosion protection efficacy of a stabilised , stannous fluoride ( SnF@ ) dentifrice versus a sodium fluoride ( NaF ) dentifrice using a modified in situ clinical model .", "sentence_id": 0}
+{"abstract_id": "24571704", "label": "methods", "text": "This study , a randomised parallel group in situ design with in vivo product use and ex vivo acid challenge , compared : A , a dentifrice containing @,@ ppm F as NaF ; B , a dentifrice containing @,@ ppm F ( @,@ ppm F as SnF@ + @ ppm F as NaF ) ; and T , tap water .", "sentence_id": 1}
+{"abstract_id": "24571704", "label": "methods", "text": "Sample size was n = @ per group ( total of @ subjects ) and within each subject appliances were placed on each side of the mouth ( left and right ) .", "sentence_id": 2}
+{"abstract_id": "24571704", "label": "methods", "text": "Enamel specimens were placed in different positions of the mouth ( front , mid-front , mid-rear , rear ) in each appliance ( total = @ specimens per subject ) .", "sentence_id": 3}
+{"abstract_id": "24571704", "label": "methods", "text": "Product treatment was twice per day ( lingual brushing for @ seconds followed by swishing for @ seconds with the resultant product/saliva slurry ) in vivo for @ days , and ex vivo acid treatment ( @ m citric acid @ minutes four times per day ; total exposure time = @ minutes ) .", "sentence_id": 4}
+{"abstract_id": "24571704", "label": "methods", "text": "Data were analysed using a general linear repeated measures model with treatment , side and position as fixed effects .", "sentence_id": 5}
+{"abstract_id": "24571704", "label": "methods", "text": "Within subjects , correlations were modelled assuming a different correlation and variance for treatment B relative to the other groups .", "sentence_id": 6}
+{"abstract_id": "24571704", "label": "methods", "text": "Pairwise treatment differences were performed using a @ % two-sided significance level .", "sentence_id": 7}
+{"abstract_id": "24571704", "label": "results", "text": "Enamel loss ( in m ) was significantly lower ( P < @ ) for treatment B versus treatments A and T. Treatment B reduced enamel surface loss by @ % relative to treatment A.", "sentence_id": 8}
+{"abstract_id": "24571704", "label": "results", "text": "There was no statistical difference in mean enamel loss ( P = @ ) between treatments A and T. Enamel loss was not statistically different for side ( left vs. right ; P = @ ) or position ( front , mid-front , mid-rear , rear ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24571704", "label": "conclusions", "text": "This modified in situ erosion model confirmed the enhanced erosion protection benefits of a stabilised SnF@ dentifrice versus a conventional NaF dentifrice , validating the ability of the model to safely and effectively demonstrate differences in the erosion protection potential of oral care products .", "sentence_id": 10}
+{"abstract_id": "24356394", "label": "background", "text": "Renin-angiotensin system ( RAS ) inhibition has proven to be helpful in reducing cardiovascular and kidney disease progression in the general population ; whether kidney transplant patients would derive similar benefits is unknown .", "sentence_id": 0}
+{"abstract_id": "24356394", "label": "background", "text": "RAS inhibition also reduces posttransplantation erythrocytosis in kidney transplant recipients , but its effect on hemoglobin ( Hb ) levels in patients without posttransplantation erythrocytosis is unclear .", "sentence_id": 1}
+{"abstract_id": "24356394", "label": "methods", "text": "The Specific Management of Anemia and Hypertension in Renal Transplant ( SMAhRT ) recipients study was designed to examine the cardiovascular benefits of RAS blockade with telmisartan @ mg versus placebo , and Hb management with darbepoetin in a randomized , double-blind , single-center controlled trial in @,@ patients over @ years .", "sentence_id": 2}
+{"abstract_id": "24356394", "label": "methods", "text": "The primary efficacy variable was a composite of all-cause mortality , myocardial infarction or stroke .", "sentence_id": 3}
+{"abstract_id": "24356394", "label": "results", "text": "The SMAhRT study was stopped prematurely due to a lower than expected event rate .", "sentence_id": 4}
+{"abstract_id": "24356394", "label": "results", "text": "At that point , @ patients were enrolled and were followed for a mean duration of @ months .", "sentence_id": 5}
+{"abstract_id": "24356394", "label": "results", "text": "The use of RAS blockade was not associated with an increased risk of adverse events such as worsening anemia or hyperkalemia .", "sentence_id": 6}
+{"abstract_id": "24356394", "label": "results", "text": "Likewise , the correction of Hb with darbepoetin was not associated with any increase in thrombotic events .", "sentence_id": 7}
+{"abstract_id": "24356394", "label": "conclusions", "text": "This study provides insight into the safety of RAS inhibition and Hb correction with an erythrocyte-stimulating agent in kidney transplant recipients .", "sentence_id": 8}
+{"abstract_id": "25311881", "label": "objective", "text": "Although many initiatives exist to improve the availability of healthy foods in corner stores , few randomized trials have assessed their effects .", "sentence_id": 0}
+{"abstract_id": "25311881", "label": "objective", "text": "This study evaluated , in a randomized controlled trial , the effects of a first-generation healthy corner store intervention on students ' food and beverage purchases over a @-year period .", "sentence_id": 1}
+{"abstract_id": "25311881", "label": "methods", "text": "Participants ( n = @ ) were fourth - , fifth - , and sixth-grade students .", "sentence_id": 2}
+{"abstract_id": "25311881", "label": "methods", "text": "Ten schools and their nearby corner stores ( n = @ ) were randomly assigned to the healthy corner store intervention or an assessment-only control .", "sentence_id": 3}
+{"abstract_id": "25311881", "label": "methods", "text": "Intercept surveys directly assessed the nutritional characteristics of students ' corner store purchases at baseline , @ and @ years .", "sentence_id": 4}
+{"abstract_id": "25311881", "label": "methods", "text": "Students ' weight and heights were measured at baseline , @ and @ years .", "sentence_id": 5}
+{"abstract_id": "25311881", "label": "results", "text": "There were no differences in energy content per intercept purchased from control or intervention schools at year @ ( P = @ ) or @ ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25311881", "label": "results", "text": "There were no differences between control and intervention students in BMI z score ( year @ , P = @ ; year @ , P = @ ) or obesity prevalence ( year @ , P = @ ; year @ , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25311881", "label": "conclusions", "text": "A healthy corner store initiative did not result in significant changes in the energy content of corner store purchases or in continuous or categorical measures of obesity .", "sentence_id": 8}
+{"abstract_id": "25311881", "label": "conclusions", "text": "These data will help to inform future interventions .", "sentence_id": 9}
+{"abstract_id": "24625239", "label": "objective", "text": "We investigated the effects of dietary intervention with canola or olive oil in comparison with commonly used refined oil in Asian Indians with nonalcoholic fatty liver disease ( NAFLD ) .", "sentence_id": 0}
+{"abstract_id": "24625239", "label": "methods", "text": "This was a @-month intervention study including @ males with NAFLD , matched for age and body mass index ( BMI ) .", "sentence_id": 1}
+{"abstract_id": "24625239", "label": "methods", "text": "Subjects were randomized into three groups to receive olive oil ( n = @ ) , canola oil ( n = @ ) , and commonly used soyabean/safflower oil ( control ; n = @ ) as cooking medium ( not exceeding @ g/day ) along with counseling for therapeutic lifestyle changes .", "sentence_id": 2}
+{"abstract_id": "24625239", "label": "methods", "text": "The BMI , fasting blood glucose ( FBG ) and insulin levels , lipids , homeostasis model of assessment for insulin resistance ( HOMA-IR ) , HOMA denoting - cell function ( HOMA-CF ) , and disposition index ( DI ) were measured at pre - and post-intervention .", "sentence_id": 3}
+{"abstract_id": "24625239", "label": "methods", "text": "Data were analyzed with one-way analysis of variance ( ANOVA ) and Tukey 's Honestly Significant Difference multiple comparison test procedures .", "sentence_id": 4}
+{"abstract_id": "24625239", "label": "results", "text": "Olive oil intervention led to a significant decrease in weight and BMI ( ANOVA , P = @ ) compared with the control oil group .", "sentence_id": 5}
+{"abstract_id": "24625239", "label": "results", "text": "In a comparison of olive and canola oil , a significant decrease in fasting insulin level , HOMA-IR , HOMA-CF , and DI ( P < @ ) was observed in the olive oil group .", "sentence_id": 6}
+{"abstract_id": "24625239", "label": "results", "text": "Pre - and post-intervention analysis revealed a significant increase in high-density lipoprotein level ( P = @ ) in the olive oil group and a significant decrease in FBG ( P = @ ) and triglyceride ( P = @ ) levels in the canola oil group .", "sentence_id": 7}
+{"abstract_id": "24625239", "label": "results", "text": "The pre - and post-intervention difference in liver span was significant only in the olive ( @ @ cm ; P < @ ) and canola ( @ @ cm ; P < @ ) oil groups .", "sentence_id": 8}
+{"abstract_id": "24625239", "label": "results", "text": "In the olive and canola oil groups , post-intervention grading of fatty liver was reduced significantly ( grade I , from @ % to @ % and from @ % to @ % , respectively -LSB- P < @ -RSB- ; grade II , from @ % to @ % and from @ % to @ % , respectively -LSB- P < @ -RSB- ; and grade III , from @ % to none and from @ % to none , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24625239", "label": "results", "text": "In contrast , in the control oil group no significant change was observed .", "sentence_id": 10}
+{"abstract_id": "24625239", "label": "conclusions", "text": "Results suggest significant improvements in grading of fatty liver , liver span , measures of insulin resistance , and lipids with use of canola and olive oil compared with control oils in Asian Indians with NAFLD .", "sentence_id": 11}
+{"abstract_id": "24378475", "label": "objective", "text": "An association of clinical and subclinical hypothyroidism with mild cognitive impairment ( MCI ) has not been established .", "sentence_id": 0}
+{"abstract_id": "24378475", "label": "objective", "text": "To evaluate the association of clinical and subclinical hypothyroidism with MCI in a large population-based cohort .", "sentence_id": 1}
+{"abstract_id": "24378475", "label": "methods", "text": "A cross-sectional , population-based study was conducted in Olmsted County , Minnesota .", "sentence_id": 2}
+{"abstract_id": "24378475", "label": "methods", "text": "Randomly selected participants were aged @ to @ years on October @ , @ , and were without documented prevalent dementia -LSB- CORRECTED -RSB- .", "sentence_id": 3}
+{"abstract_id": "24378475", "label": "methods", "text": "A total of @ participants were evaluated and underwent in-person interview , neurologic evaluation , and neuropsychological testing to assess performance in memory , attention/executive function , and visuospatial and language domains .", "sentence_id": 4}
+{"abstract_id": "24378475", "label": "methods", "text": "Participants were categorized by consensus as being cognitively normal , having MCI , or having dementia according to published criteria .", "sentence_id": 5}
+{"abstract_id": "24378475", "label": "methods", "text": "Clinical and subclinical hypothyroidism were ascertained from a medical records linkage system .", "sentence_id": 6}
+{"abstract_id": "24378475", "label": "methods", "text": "Association of clinical and subclinical hypothyroidism with MCI .", "sentence_id": 7}
+{"abstract_id": "24378475", "label": "results", "text": "Among @ eligible participants , the frequency of MCI was @ % in @ individuals with normal thyroid function , @ % in @ persons with clinical hypothyroidism , and @ % in @ individuals with subclinical hypothyroidism .", "sentence_id": 8}
+{"abstract_id": "24378475", "label": "results", "text": "After adjusting for covariates ( age , educational level , sex , apolipoprotein E @ , depression , diabetes mellitus , hypertension , stroke , body mass index , and coronary artery disease ) we found no significant association between clinical or subclinical hypothyroidism and MCI ( odds ratio -LSB- OR -RSB- , @ -LSB- @ % CI , @-@ @ -RSB- and @ -LSB- @-@ @ -RSB- , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24378475", "label": "results", "text": "No effect of sex interaction was seen on these effects .", "sentence_id": 10}
+{"abstract_id": "24378475", "label": "results", "text": "In stratified analysis , the odds of MCI with clinical and subclinical hypothyroidism among men was @ ( @ % CI , @-@ @ ) and @ ( @-@ @ ) and , among women , was @ ( @-@ @ ) and @ ( @-@ @ ) , respectively .", "sentence_id": 11}
+{"abstract_id": "24378475", "label": "conclusions", "text": "In this population-based cohort of elderly people , neither clinical nor subclinical hypothyroidism was associated with MCI .", "sentence_id": 12}
+{"abstract_id": "24378475", "label": "conclusions", "text": "Our findings need to be validated in a separate setting using the published criteria for MCI and confirmed in a longitudinal study .", "sentence_id": 13}
+{"abstract_id": "24640441", "label": "objective", "text": "To evaluate the clinical performance of adhesive restorations of resin composite and resin-modified glass-ionomer cements in primary molars .", "sentence_id": 0}
+{"abstract_id": "24640441", "label": "methods", "text": "This randomized clinical trial included subjects ( @-@ year-old children ) selected at two university centers ( UFRGS and UNIFRA ) .", "sentence_id": 1}
+{"abstract_id": "24640441", "label": "methods", "text": "The sample consisted of @ primary molars presenting active cavitated carious lesions ( with radiographic involvement of the inner half of the dentin ) , located on the occlusal and occlusal-proximal surface .", "sentence_id": 2}
+{"abstract_id": "24640441", "label": "methods", "text": "The sample was randomly divided into three groups , according to the restorative material : ( G@ ) universal restorative system ( Adper Single Bond @ system and Filtek Z@ ) ; ( G@ ) : Resin-modified glass-ionomer cement ( Vitremer ) ; and ( G@ ) : Low shrink restorative system ( Filtek P@ ) .", "sentence_id": 3}
+{"abstract_id": "24640441", "label": "methods", "text": "The restorations were clinically and radiographically followed every @ months for up to @ months using the USPHS modified criteria for clinical evaluation .", "sentence_id": 4}
+{"abstract_id": "24640441", "label": "methods", "text": "Survival estimates for restoration longevity were evaluated using the Kaplan-Meier method .", "sentence_id": 5}
+{"abstract_id": "24640441", "label": "methods", "text": "Log-rank test ( P < @ ) was used to compare the differences in the success rate according to the type of the restorative material .", "sentence_id": 6}
+{"abstract_id": "24640441", "label": "results", "text": "The type of restorative material used did not influence the longevity of the restorations .", "sentence_id": 7}
+{"abstract_id": "24640441", "label": "results", "text": "After clinical follow-up , there was no statistical difference in the rates of success for the three materials used to restore active cavitated carious lesions in primary molars .", "sentence_id": 8}
+{"abstract_id": "24640441", "label": "results", "text": "The survival rates for the follow-up were similar regarding the number of restored surfaces and the caries removal technique ( partial or complete ) .", "sentence_id": 9}
+{"abstract_id": "24640441", "label": "results", "text": "Mean estimated time of survival was @ months ( @ % CI : @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24640441", "label": "results", "text": "Estimated survival rates of the restorations were @ % , @ % , @ % and @ % at @ , @ , @ and @ months of clinical evaluations , respectively .", "sentence_id": 11}
+{"abstract_id": "25027180", "label": "objective", "text": "This study aimed to evaluate whether a high relative ADP induced aggregation ( r-ADP-agg ) is associated with an increased mortality in patients after coronary stent implantation .", "sentence_id": 0}
+{"abstract_id": "25027180", "label": "background", "text": "Several trials were not able to improve clinical outcome by adapting platelet inhibition in patients after coronary stent implantation and high platelet reactivity ( HPR ) .", "sentence_id": 1}
+{"abstract_id": "25027180", "label": "background", "text": "Platelet monitoring is complex and conventional definition of adenosindiphosphate ( ADP ) induced aggregation alone might not transfer the whole picture of adequate platelet inhibition in vivo .", "sentence_id": 2}
+{"abstract_id": "25027180", "label": "methods", "text": "In a prospective single-centre observational trial multiple electrode aggregometry was performed in whole blood of patients after stent implantation .", "sentence_id": 3}
+{"abstract_id": "25027180", "label": "methods", "text": "r-ADP-agg was defined as the ADP-thrombin receptor activating peptide ratio to reflect an individual degree of P@Y@ dependent platelet inhibition with a cut-off value for HPR of @ % .", "sentence_id": 4}
+{"abstract_id": "25027180", "label": "methods", "text": "The primary end point was mortality .", "sentence_id": 5}
+{"abstract_id": "25027180", "label": "results", "text": "Follow-up was completed in @ of @ patients ( @ % ) with a mean follow-up time of @ years .", "sentence_id": 6}
+{"abstract_id": "25027180", "label": "results", "text": "@ ( @ % ) patients revealed an r-ADP-agg @ % .", "sentence_id": 7}
+{"abstract_id": "25027180", "label": "results", "text": "An r-ADP-agg @ % was associated with an increased mortality -LSB- unadjusted hazard ratio ( HR ) @ ( @-@ @ ) ; p = @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "25027180", "label": "results", "text": "In a multivariable Cox regression analysis mortality was independently associated with an r-ADP-agg @ % -LSB- HR @ ( @-@ @ ) ; p = @ -RSB- , ACS-setting -LSB- HR @ ( @-@ @ ) ; p = @ -RSB- and severely reduced LV function -LSB- HR @ ( @-@ @ ) ; p = @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "25027180", "label": "conclusions", "text": "An r-ADP-agg @ % is associated with an increased mortality in patients after coronary stent implantation .", "sentence_id": 10}
+{"abstract_id": "25027180", "label": "conclusions", "text": "Furthermore , r-ADP-agg might represent a better tool to predict clinical outcome than the conventional ADP induced platelet aggregation alone .", "sentence_id": 11}
+{"abstract_id": "25946762", "label": "background", "text": "The familial Mediterranean fever @ score ( FMF@ ) score was recently devised to define response to treatment and as an outcome measure for clinical trials of FMF .", "sentence_id": 0}
+{"abstract_id": "25946762", "label": "objective", "text": "To examine the performance of the FMF@ score in a previously published trial of rilonacept for patients whose FMF was resistant or intolerant to colchicine .", "sentence_id": 1}
+{"abstract_id": "25946762", "label": "methods", "text": "We re-analyzed the data from our controlled trial of rilonacept vs. placebo in @ patients with colchicine-resistant or intolerant FMF using the FMF@ score as the primary outcome .", "sentence_id": 2}
+{"abstract_id": "25946762", "label": "methods", "text": "The FMF@ score required improvement by @ in five of six criteria ( attack frequency , attack duration , global patient assessment , global physician assessment , frequency of attacks with arthritis , and levels of acute-phase reactants ) without worsening of the sixth criterion .", "sentence_id": 3}
+{"abstract_id": "25946762", "label": "results", "text": "In the original trial rilonacept was considered effective according to the primary outcome measure ( differences in the attack frequency ) with eight analyzable patients considered responders and four as non-responders .", "sentence_id": 4}
+{"abstract_id": "25946762", "label": "results", "text": "According to the FMF@ score , only two participants would have been considered respondersto rilonacept , and one to placebo .", "sentence_id": 5}
+{"abstract_id": "25946762", "label": "results", "text": "Only two participants had @ % differences between rilonacept and placebo in five criteria .", "sentence_id": 6}
+{"abstract_id": "25946762", "label": "results", "text": "The major explanation for non-response to treatment was that with rilonacept the duration of attack decreased by @ % in only @ participants and @ participants had no attacks of arthritis either during screening ( before randomization ) or during treatment with rilonacept .", "sentence_id": 7}
+{"abstract_id": "25946762", "label": "conclusions", "text": "The proposed FMF@ score did not differentiate well between responders and non-responders compared to the a priori defined primary outcome measure in this successful controlled study .", "sentence_id": 8}
+{"abstract_id": "24590751", "label": "objective", "text": "To test the effectiveness of messages designed to reduce vaccine misperceptions and increase vaccination rates for measles-mumps-rubella ( MMR ) .", "sentence_id": 0}
+{"abstract_id": "24590751", "label": "methods", "text": "A Web-based nationally representative @-wave survey experiment was conducted with @ parents age @ years and older residing in the United States who have children in their household age @ years or younger ( conducted June-July @ ) .", "sentence_id": 1}
+{"abstract_id": "24590751", "label": "methods", "text": "Parents were randomly assigned to receive @ of @ interventions : ( @ ) information explaining the lack of evidence that MMR causes autism from the Centers for Disease Control and Prevention ; ( @ ) textual information about the dangers of the diseases prevented by MMR from the Vaccine Information Statement ; ( @ ) images of children who have diseases prevented by the MMR vaccine ; ( @ ) a dramatic narrative about an infant who almost died of measles from a Centers for Disease Control and Prevention fact sheet ; or to a control group .", "sentence_id": 2}
+{"abstract_id": "24590751", "label": "results", "text": "None of the interventions increased parental intent to vaccinate a future child .", "sentence_id": 3}
+{"abstract_id": "24590751", "label": "results", "text": "Refuting claims of an MMR/autism link successfully reduced misperceptions that vaccines cause autism but nonetheless decreased intent to vaccinate among parents who had the least favorable vaccine attitudes .", "sentence_id": 4}
+{"abstract_id": "24590751", "label": "results", "text": "In addition , images of sick children increased expressed belief in a vaccine/autism link and a dramatic narrative about an infant in danger increased self-reported belief in serious vaccine side effects .", "sentence_id": 5}
+{"abstract_id": "24590751", "label": "conclusions", "text": "Current public health communications about vaccines may not be effective .", "sentence_id": 6}
+{"abstract_id": "24590751", "label": "conclusions", "text": "For some parents , they may actually increase misperceptions or reduce vaccination intention .", "sentence_id": 7}
+{"abstract_id": "24590751", "label": "conclusions", "text": "Attempts to increase concerns about communicable diseases or correct false claims about vaccines may be especially likely to be counterproductive .", "sentence_id": 8}
+{"abstract_id": "24590751", "label": "conclusions", "text": "More study of pro-vaccine messaging is needed .", "sentence_id": 9}
+{"abstract_id": "24868024", "label": "objective", "text": "In Asian countries , paclitaxel once per week is used as second-line treatment in advanced gastric cancer , including human epidermal growth factor receptor @ ( HER@ ) - positive tumors .", "sentence_id": 0}
+{"abstract_id": "24868024", "label": "objective", "text": "The role of anti-HER@ agents , including lapatinib , in this setting and population is unclear .", "sentence_id": 1}
+{"abstract_id": "24868024", "label": "methods", "text": "TyTAN was a two-part , parallel-group , phase III study in Asian patients .", "sentence_id": 2}
+{"abstract_id": "24868024", "label": "methods", "text": "An open-label , dose-optimization phase ( n = @ ) was followed by a randomized phase ( n = @ ) , in which patients who were HER@ positive by fluorescence in situ hybridization ( FISH ) received lapatinib @,@ mg once per day plus once-per-week paclitaxel @ mg/m ( @ ) or paclitaxel alone .", "sentence_id": 3}
+{"abstract_id": "24868024", "label": "methods", "text": "The primary end point was overall survival ( OS ) .", "sentence_id": 4}
+{"abstract_id": "24868024", "label": "methods", "text": "Secondary end points included progression-free survival ( PFS ) , time to progression ( TTP ) , overall response rate ( ORR ) , time to response , response duration , and safety .", "sentence_id": 5}
+{"abstract_id": "24868024", "label": "methods", "text": "Analyses were based on immunohistochemistry ( IHC ) and gastrectomy status , prior trastuzumab therapy , and regional subpopulations .", "sentence_id": 6}
+{"abstract_id": "24868024", "label": "results", "text": "Median OS was @ months with lapatinib plus paclitaxel versus @ months with paclitaxel alone ( P = @ ) , with no significant difference in median PFS ( @ v @ months ) or TTP ( @ v @ months ) .", "sentence_id": 7}
+{"abstract_id": "24868024", "label": "results", "text": "ORR was higher with lapatinib plus paclitaxel versus paclitaxel alone ( odds ratio , @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24868024", "label": "results", "text": "Better efficacy with lapatinib plus paclitaxel was demonstrated in IHC@ + compared with IHC@/@ + and @ + patients and in Chinese compared with Japanese patients .", "sentence_id": 9}
+{"abstract_id": "24868024", "label": "results", "text": "A similar proportion of patients experienced adverse events with each treatment ( lapatinib plus paclitaxel , @ % v paclitaxel alone , @ % ) .", "sentence_id": 10}
+{"abstract_id": "24868024", "label": "conclusions", "text": "Lapatinib plus paclitaxel demonstrated activity in the second-line treatment of patients with HER@ FISH-positive IHC@ + advanced gastric cancer but did not significantly improve OS in the intent-to-treat population .", "sentence_id": 11}
+{"abstract_id": "24470701", "label": "objective", "text": "To evaluate the efficacy of a brief @-w group-administered treatment program of cognitive behavior therapy for insomnia ( CBT-I ) for older adults with sleep maintenance insomnia .", "sentence_id": 0}
+{"abstract_id": "24470701", "label": "methods", "text": "Randomized controlled trial of CBT-I compared to waitlist control with comparisons at pretreatment , posttreatment , and @-mo follow-up .", "sentence_id": 1}
+{"abstract_id": "24470701", "label": "methods", "text": "Flinders University Sleep and Circadian Rhythm Research Laboratory , Adelaide , South Australia .", "sentence_id": 2}
+{"abstract_id": "24470701", "label": "methods", "text": "One-hundred eighteen adults with sleep maintenance insomnia ( mean age = @ y , standard deviation = @ y , male = @ ) .", "sentence_id": 3}
+{"abstract_id": "24470701", "label": "methods", "text": "A @-w , group-based treatment program of CBT-I including bedtime restriction therapy , sleep education , and cognitive restructuring .", "sentence_id": 4}
+{"abstract_id": "24470701", "label": "methods", "text": "Seven-day sleep diaries , actigraphy , and several self-report measures to assess perceived insomnia severity , daytime functioning , and confidence in and beliefs about sleep .", "sentence_id": 5}
+{"abstract_id": "24470701", "label": "results", "text": "The brief group-administered CBT-I program produced improvements in the timing and quality of sleep including later bedtimes , earlier out-of-bed times , reduced wake after sleep onset , and improved sleep efficiency .", "sentence_id": 6}
+{"abstract_id": "24470701", "label": "results", "text": "Participants also reported a reduction of the Insomnia Severity Index , Flinders Fatigue Scale , Epworth Sleepiness Scale , Daytime Feeling and Functioning Scale , Sleep Anticipatory Anxiety Questionnaire , the Dysfunctional Beliefs and Attitudes Scale , and increased Sleep Self-Efficacy Scale .", "sentence_id": 7}
+{"abstract_id": "24470701", "label": "conclusions", "text": "The treatment program used in the current study has demonstrated potential for a brief , inexpensive , and effective treatment of sleep maintenance insomnia in the older adult population .", "sentence_id": 8}
+{"abstract_id": "24351875", "label": "background", "text": "Eating carbohydrate foods with a high glycemic index ( GI ) has been postulated to result in fetoplacental overgrowth and higher infant body fat .", "sentence_id": 0}
+{"abstract_id": "24351875", "label": "background", "text": "A diet with a low glycemic index ( LGI ) has been shown to reduce birth percentiles and the ponderal index ( PI ) .", "sentence_id": 1}
+{"abstract_id": "24351875", "label": "objective", "text": "We investigated whether offering LGI dietary advice at the first antenatal visit would result in a lower fetal birth weight , birth percentile , and PI than providing healthy eating ( HE ) advice .", "sentence_id": 2}
+{"abstract_id": "24351875", "label": "objective", "text": "This advice had to be presented within the resources of routine antenatal care .", "sentence_id": 3}
+{"abstract_id": "24351875", "label": "methods", "text": "The Pregnancy and Glycemic Index Outcomes study was a @-arm , parallel-design , randomized , controlled trial that compared the effects of LGI dietary advice with HE advice on pregnancy outcomes .", "sentence_id": 4}
+{"abstract_id": "24351875", "label": "methods", "text": "Eligible volunteers who attended for routine antenatal care at < @ wk of gestation were randomly assigned to either group .", "sentence_id": 5}
+{"abstract_id": "24351875", "label": "results", "text": "A total of @ women were enrolled , and @ women had final data considered .", "sentence_id": 6}
+{"abstract_id": "24351875", "label": "results", "text": "In the LGI group , the GI was reduced from a mean ( SEM ) of @ @ at enrollment to @ @ ( P < @ ) at the final assessment .", "sentence_id": 7}
+{"abstract_id": "24351875", "label": "results", "text": "There were no significant differences in primary outcomes of fetal birth weight , birth percentile , or PI .", "sentence_id": 8}
+{"abstract_id": "24351875", "label": "results", "text": "In a multivariate regression analysis , the glycemic load was the only significant dietary predictor ( P = @ ) of primary outcomes but explained < @ % of all variation .", "sentence_id": 9}
+{"abstract_id": "24351875", "label": "conclusions", "text": "A low-intensity dietary intervention with an LGI diet compared with an HE diet in pregnancy did not result in any significant differences in birth weight , fetal percentile , or PI .", "sentence_id": 10}
+{"abstract_id": "25359163", "label": "background", "text": "A large body of epidemiological and experimental evidence suggests that vitamin D deficiency may promote hypertension .", "sentence_id": 0}
+{"abstract_id": "25359163", "label": "background", "text": "This raises the possibility that vitamin D supplementation could be a simple intervention to reduce blood pressure , but data from prospective , randomized trials are limited .", "sentence_id": 1}
+{"abstract_id": "25359163", "label": "results", "text": "A double-blind , randomized , controlled trial was conducted at @ sites in the United States .", "sentence_id": 2}
+{"abstract_id": "25359163", "label": "results", "text": "We enrolled @ individuals @ to @ years of age with low vitamin D status ( @-hydroxyvitamin D levels @ ng/mL ) and systolic blood pressure of @ to @ mm Hg .", "sentence_id": 3}
+{"abstract_id": "25359163", "label": "results", "text": "Participants were randomized to high-dose ( @ IU/d ) versus low-dose ( @ IU/d ) oral vitamin D@ for @ months .", "sentence_id": 4}
+{"abstract_id": "25359163", "label": "results", "text": "The primary end point was change in mean @-hour systolic blood pressure .", "sentence_id": 5}
+{"abstract_id": "25359163", "label": "results", "text": "Secondary end points included change in ambulatory diastolic blood pressure and clinic systolic and diastolic blood pressures .", "sentence_id": 6}
+{"abstract_id": "25359163", "label": "results", "text": "The median age was @ years , and @ % of participants were men .", "sentence_id": 7}
+{"abstract_id": "25359163", "label": "results", "text": "Forty-six percent of participants were white , and @ % were black .", "sentence_id": 8}
+{"abstract_id": "25359163", "label": "results", "text": "The median @-hydroxyvitamin D level at baseline was @ ng/mL .", "sentence_id": 9}
+{"abstract_id": "25359163", "label": "results", "text": "Four-hundred fifty-five participants ( @ % ) had at least @ follow-up blood pressure measurement ; @ participants ( @ % ) completed the full @-month study .", "sentence_id": 10}
+{"abstract_id": "25359163", "label": "results", "text": "At the end of the study , there was no significant difference in the primary end point ( change in mean @-hour systolic blood pressure , -@ versus -@ mm Hg in the high-dose and low-dose arms ; P = @ ) or in any of the secondary end points .", "sentence_id": 11}
+{"abstract_id": "25359163", "label": "results", "text": "Furthermore , there was no evidence of association between change in @-hydroxyvitamin D and change in @-hour systolic blood pressure at @ months ( Spearman correlation coefficient , -@ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25359163", "label": "results", "text": "Results were consistent across prespecified subgroups .", "sentence_id": 13}
+{"abstract_id": "25359163", "label": "conclusions", "text": "Vitamin D supplementation did not reduce blood pressure in individuals with prehypertension or stage I hypertension and vitamin D deficiency .", "sentence_id": 14}
+{"abstract_id": "25359163", "label": "conclusions", "text": "Our findings suggest that the association between vitamin D status and elevated blood pressure noted in observational studies is not causal .", "sentence_id": 15}
+{"abstract_id": "24831438", "label": "background", "text": "Threshold levels for peanut allergy determined by using oral challenges are important for the food industry with regard to allergen labeling .", "sentence_id": 0}
+{"abstract_id": "24831438", "label": "background", "text": "Moreover , the utility of biological markers in predicting threshold levels is uncertain .", "sentence_id": 1}
+{"abstract_id": "24831438", "label": "objective", "text": "We sought to use a modified oral food challenge regimen that might determine threshold levels for peanut allergy mimicking a more real-life exposure and to correlate the eliciting dose ( ED ) and severity of clinical reaction in children with peanut allergy with B-cell , T-cell , and effector cell markers .", "sentence_id": 2}
+{"abstract_id": "24831438", "label": "methods", "text": "A modified food challenge procedure with doses scheduled @ hours apart was used in @ children with peanut allergy .", "sentence_id": 3}
+{"abstract_id": "24831438", "label": "methods", "text": "All children received a maximum of @ semi-log increasing titration steps of roasted peanuts ranging from @ to @ mg of peanut protein until objective allergic reactions occurred .", "sentence_id": 4}
+{"abstract_id": "24831438", "label": "methods", "text": "Severity of symptoms was graded from I to V. Biological markers were measured before challenge .", "sentence_id": 5}
+{"abstract_id": "24831438", "label": "results", "text": "Forty-five of @ patients showed objective symptoms after greater than @ minutes , with a median latency of clinical reaction of @ minutes .", "sentence_id": 6}
+{"abstract_id": "24831438", "label": "results", "text": "By using a log-normal dose-distribution model , the ED@ was calculated to be @ mg of peanut protein .", "sentence_id": 7}
+{"abstract_id": "24831438", "label": "results", "text": "The ED was significantly and inversely correlated with peanut - and Ara h @-specific IgE levels , skin prick test responses , basophil activation , and TH@ cytokine production by PBMCs .", "sentence_id": 8}
+{"abstract_id": "24831438", "label": "results", "text": "Symptom severity did not correlate with any of the markers or the ED .", "sentence_id": 9}
+{"abstract_id": "24831438", "label": "conclusions", "text": "This modified food challenge procedure might better reflect threshold levels for peanut allergy than the standard procedure because most of the patients reacted at a time interval of greater than @ minutes .", "sentence_id": 10}
+{"abstract_id": "24831438", "label": "conclusions", "text": "By using this model , threshold levels , but not severity , could be correlated with biological markers .", "sentence_id": 11}
+{"abstract_id": "25957003", "label": "objective", "text": "Bleeding esophageal varices has been studied extensively , but bleeding gastric varices ( BGV ) has received much less investigation .", "sentence_id": 0}
+{"abstract_id": "25957003", "label": "objective", "text": "However , BGV has been reported in @ % of patients with acute variceal bleeding .", "sentence_id": 1}
+{"abstract_id": "25957003", "label": "objective", "text": "In our studies of @,@ bleeding cirrhotics , @ % were bleeding from gastric varices .", "sentence_id": 2}
+{"abstract_id": "25957003", "label": "objective", "text": "BGV mortality rate of @-@ % has been reported .", "sentence_id": 3}
+{"abstract_id": "25957003", "label": "objective", "text": "The BGV literature has mainly involved retrospective case reports , often with short-term follow-up .", "sentence_id": 4}
+{"abstract_id": "25957003", "label": "objective", "text": "We sought to describe the results of a prospective , randomized , controlled trial ( RCT ) in unselected , consecutive patients with BGV comparing endoscopic therapy ( ET ) with portacaval shunt ( PCS ; n = @ ) , and later comparing emergency transjugular intrahepatic portosystemic shunt ( TIPS ) with emergency portacaval shunt ( EPCS ; n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25957003", "label": "methods", "text": "Initially , our RCT involved @ patients with BGV comparing ET with direct PCS regarding control of bleeding , mortality rate , and disability .", "sentence_id": 6}
+{"abstract_id": "25957003", "label": "methods", "text": "When entry of patients ended , the RCT was expanded to compare emergency TIPS with EPCS ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "25957003", "label": "methods", "text": "This RCT of BGV was separate from our other RCTs of bleeding esophageal varices .", "sentence_id": 8}
+{"abstract_id": "25957003", "label": "methods", "text": "Initially , ET was compared with PCS .", "sentence_id": 9}
+{"abstract_id": "25957003", "label": "methods", "text": "In the second part of our RCT , emergency TIPS was compared with emergency PCS ( EPCS ) .", "sentence_id": 10}
+{"abstract_id": "25957003", "label": "methods", "text": "Outcomes were survival , control of bleeding , portal-systemic encephalopathy ( PSE ) , quality of life , and direct costs of care .", "sentence_id": 11}
+{"abstract_id": "25957003", "label": "methods", "text": "In the RCT of ET versus PCS , @ and @ % , respectively , were in Child class C.", "sentence_id": 12}
+{"abstract_id": "25957003", "label": "methods", "text": "In the expanded RCT of TIPS versus EPCS , @ and @ % , respectively , were in Child class C. Permanent control of BGV was achieved in @-@ % of patients treated by emergency or elective PCS , compared with @-@ % by ET .", "sentence_id": 13}
+{"abstract_id": "25957003", "label": "methods", "text": "TIPS was even less effective , achieving long-term control of BGV in only @ % .", "sentence_id": 14}
+{"abstract_id": "25957003", "label": "methods", "text": "Survival rates after PCS were greater at all time intervals and in all Child classes ( P < @ ) .", "sentence_id": 15}
+{"abstract_id": "25957003", "label": "methods", "text": "Repeated episodes of PSE occurred in @ % of TIPS patients , @-@ % treated by ET , and @-@ % treated by PCS .", "sentence_id": 16}
+{"abstract_id": "25957003", "label": "methods", "text": "Shunt stenosis or occlusion occurred in @ % of TIPS patients , in contrast with @-@ % of PCS patients .", "sentence_id": 17}
+{"abstract_id": "25957003", "label": "conclusions", "text": "These results support the conclusion that PCS is uniformly effective , whereas ET and TIPS are not very effective .", "sentence_id": 18}
+{"abstract_id": "24700992", "label": "objective", "text": "To measure the extent , determinants and results of bypassing local primary care clinics for childbirth among women in rural parts of the United Republic of Tanzania .", "sentence_id": 0}
+{"abstract_id": "24700992", "label": "methods", "text": "Women were selected in @ to complete a structured interview from a full census of all @ households in clinic catchment areas in Pwani region .", "sentence_id": 1}
+{"abstract_id": "24700992", "label": "methods", "text": "Eligibility was limited to those who had delivered between @ weeks and @ year before the interview , were at least @ years old and lived within the catchment areas .", "sentence_id": 2}
+{"abstract_id": "24700992", "label": "methods", "text": "Demographic and delivery care information and opinions on the quality of obstetric care were collected through interviews .", "sentence_id": 3}
+{"abstract_id": "24700992", "label": "methods", "text": "Clinic characteristics were collected from staff via questionnaires .", "sentence_id": 4}
+{"abstract_id": "24700992", "label": "methods", "text": "Determinants of bypassing ( i.e. delivery of the youngest child at a health centre or hospital without provider referral ) were analysed using multivariate logistic regression .", "sentence_id": 5}
+{"abstract_id": "24700992", "label": "methods", "text": "Bypasser and non-bypasser birth experiences were compared in bivariate analyses .", "sentence_id": 6}
+{"abstract_id": "24700992", "label": "results", "text": "Of @ eligible women interviewed ( @ % response rate ) , @ % ( @ ) delivered in a health facility ; @ % ( @ ) were bypassers .", "sentence_id": 7}
+{"abstract_id": "24700992", "label": "results", "text": "Bypassing likelihood increased with primiparity ( odds ratio , OR : @ ; @ % confidence interval , CI : @-@ @ ) and perceived poor quality at clinics ( OR : @ ; @ % CI : @-@ @ ) and decreased if clinics recently underwent renovations ( OR : @ ; @ % CI : @-@ @ ) and/or performed @ obstetric signal functions ( OR : @ ; @ % CI : @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24700992", "label": "results", "text": "Bypassers reported better quality of care on six of seven quality of care measures .", "sentence_id": 9}
+{"abstract_id": "24700992", "label": "conclusions", "text": "Many pregnant women , especially first-time mothers , choose to bypass local primary care clinics for childbirth .", "sentence_id": 10}
+{"abstract_id": "24700992", "label": "conclusions", "text": "Perceived poor quality of care at clinics was an important reason for bypassing .", "sentence_id": 11}
+{"abstract_id": "24700992", "label": "conclusions", "text": "Primary care is failing to meet the obstetric needs of many women in this rural , low-income setting .", "sentence_id": 12}
+{"abstract_id": "25127483", "label": "background", "text": "Long-term effects of behavioural weight loss interventions on diabetes complications are unknown .", "sentence_id": 0}
+{"abstract_id": "25127483", "label": "background", "text": "In a secondary analysis of the Look AHEAD ( Action for Health in Diabetes ) multicentre randomised clinical trial , we assessed whether an intensive lifestyle intervention ( ILI ) affects the development of nephropathy in people with type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "25127483", "label": "methods", "text": "Overweight or obese people aged @-@ years with type @ diabetes were randomly assigned ( @:@ ) to ILI or to a diabetes support and education ( DSE ) group by a central web-based data management system , stratified by clinical centre and blocked with random block sizes .", "sentence_id": 2}
+{"abstract_id": "25127483", "label": "methods", "text": "The ILI was designed to achieve and maintain weight loss through reduced caloric consumption and increased physical activity .", "sentence_id": 3}
+{"abstract_id": "25127483", "label": "methods", "text": "The interventions were terminated early because of absence of effect on the primary outcome of cardiovascular disease events in the main Look AHEAD trial .", "sentence_id": 4}
+{"abstract_id": "25127483", "label": "methods", "text": "Albuminuria and estimated glomerular filtration rate were prespecified as two of many other outcomes and were assessed from baseline until the interventions ended .", "sentence_id": 5}
+{"abstract_id": "25127483", "label": "methods", "text": "They were combined post hoc to define the main outcome for this report , very-high-risk chronic kidney disease ( CKD ) , based on the @ Kidney Disease Improving Global Outcomes ( KDIGO ) classification .", "sentence_id": 6}
+{"abstract_id": "25127483", "label": "methods", "text": "Outcomes assessors and laboratory staff were masked to treatment , but participants and interventionists were not masked .", "sentence_id": 7}
+{"abstract_id": "25127483", "label": "methods", "text": "Time-to-event data were analysed by intention to treat by the Kaplan-Meier method and proportional hazards models .", "sentence_id": 8}
+{"abstract_id": "25127483", "label": "methods", "text": "The Look AHEAD trial is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 9}
+{"abstract_id": "25127483", "label": "results", "text": "Of the @ participants randomly assigned in the Look AHEAD trial ( @ to ILI and @ to DSE ) , analyses for very-high-risk CKD were done in @ ( @ % ) of patients in the ILI group and @ ( @ % ) of those in the DSE group .", "sentence_id": 10}
+{"abstract_id": "25127483", "label": "results", "text": "After a median of @ years ( IQR @-@ ) of follow-up , the incidence of very-high-risk CKD was lower in the ILI group than in the DSE group , with incidence rates of @ cases per @ person-years in the DSE group and @ per @ person-years in the ILI group ( difference @ cases per @ person-years , hazard ratio @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25127483", "label": "results", "text": "This effect was partly attributable to reductions in bodyweight , HbA@c , and systolic blood pressure .", "sentence_id": 12}
+{"abstract_id": "25127483", "label": "results", "text": "There were no safety concerns regarding kidney-related adverse events .", "sentence_id": 13}
+{"abstract_id": "25127483", "label": "conclusions", "text": "Weight loss should be considered as an adjunct to medical treatments to prevent or delay progression of CKD in overweight or obese people with type @ diabetes .", "sentence_id": 14}
+{"abstract_id": "24420746", "label": "objective", "text": "To identify factors associated with variability in rifampin plasma pharmacokinetics and explore the relationship between rifampin pharmacokinetics and change in efavirenz plasma pharmacokinetics with rifampin coadministration .", "sentence_id": 0}
+{"abstract_id": "24420746", "label": "methods", "text": "In this randomized , cross-over study , @ healthy volunteers received either efavirenz @mg/day or efavirenz @mg with rifampin @mg/day for @days .", "sentence_id": 1}
+{"abstract_id": "24420746", "label": "methods", "text": "After a washout period of at least @weeks , subjects crossed over to the alternate @-day regimen .", "sentence_id": 2}
+{"abstract_id": "24420746", "label": "methods", "text": "Samples were obtained for pharmacokinetic assessment on day @ of each study cycle .", "sentence_id": 3}
+{"abstract_id": "24420746", "label": "methods", "text": "Drugs concentrations were determined by a validated high-performance liquid chromatography .", "sentence_id": 4}
+{"abstract_id": "24420746", "label": "methods", "text": "Pharmacokinetic parameters were calculated using noncompartmental analysis .", "sentence_id": 5}
+{"abstract_id": "24420746", "label": "methods", "text": "Multivariate analysis was used to examine factors associated with rifampin pharmacokinetics .", "sentence_id": 6}
+{"abstract_id": "24420746", "label": "methods", "text": "Spearman correlation analysis was used to investigate relationship between rifampin pharmacokinetics and change in efavirenz plasma pharmacokinetics with rifampin coadministration .", "sentence_id": 7}
+{"abstract_id": "24420746", "label": "results", "text": "Of @ evaluable subjects , the median interquartile range , rifampin peak concentration ( Cmax ) , area under the concentration-time curve ( AUC@-@hour ) , and weight-normalized clearance were @ ( @-@ @ ) g/ml , @ ( @-@ @ ) gh/ml , and @ ( @-@ @ ) L/h/kg , respectively .", "sentence_id": 8}
+{"abstract_id": "24420746", "label": "results", "text": "Solute carrier organic anion transporter family member @B@ ( SLCO@B@ ) c. @AG and SLCO@B@ c. @CA polymorphisms jointly had significant effect on rifampin Cmax ( R ( @ ) = @ ) .", "sentence_id": 9}
+{"abstract_id": "24420746", "label": "results", "text": "Male sex and SLCO@B@ c. @CA polymorphism together influenced rifampin AUC@-@hour ( R ( @ ) = @ ) and weight-normalized clearance ( R ( @ ) = @ ) .", "sentence_id": 10}
+{"abstract_id": "24420746", "label": "results", "text": "All four volunteers with rifampin Cmax less than@g/ml ( lower end of the normal range ) had c. @CA genotype .", "sentence_id": 11}
+{"abstract_id": "24420746", "label": "results", "text": "Rifampin Cmax and AUC@-@hour had no significant relationship with the efavirenz AUC@-@hour ratio or weight-normalized clearance ratio in the presence versus absence of rifampin ( p > @ ) .", "sentence_id": 12}
+{"abstract_id": "24420746", "label": "conclusions", "text": "Men with the SLCO@B@c @ CA genotype are at increased risk of lower rifampin plasma exposure .", "sentence_id": 13}
+{"abstract_id": "24420746", "label": "conclusions", "text": "However , plasma rifampin concentrations did not correlate with the extent of induction of efavirenz clearance by rifampin during coadministration .", "sentence_id": 14}
+{"abstract_id": "25456093", "label": "objective", "text": "The aim of this study is to assess the prevalence of non-opioid drug use among opioid-addicted , buprenorphine injecting individuals in Georgia , during and after a @-week course of buprenorphine-naloxone ( Suboxone ) or methadone .", "sentence_id": 0}
+{"abstract_id": "25456093", "label": "methods", "text": "Randomized controlled trial with daily observed Suboxone or methadone and weekly counseling , urine tests and timeline followback ( TLFB ) in weeks @-@ and @ , and the Addiction Severity Index ( ASI ) at weeks @ , @ , @ , @ , @ .", "sentence_id": 1}
+{"abstract_id": "25456093", "label": "results", "text": "Of the @ patients ( @/group , @ women ) , @ ( @ % ) completed the @-weeks of study treatment and @ ( @ % ) completed the @-week follow-up .", "sentence_id": 2}
+{"abstract_id": "25456093", "label": "results", "text": "At baseline , injecting more than one drug in the last @ days was reported by @ % of patients in the methadone and @ % in the Suboxone groups .", "sentence_id": 3}
+{"abstract_id": "25456093", "label": "results", "text": "Drug use was markedly reduced in both treatment conditions but there were significant differences in the prevalence of specific drugs with more opioid ( @ vs. @ % ; p = @ ) , less amphetamine ( @ vs. @ % ; p < @ ) and less marijuana ( @ vs. @ % ; p < @ ) positive urine tests in the methadone vs. Suboxone groups .", "sentence_id": 4}
+{"abstract_id": "25456093", "label": "results", "text": "At the @-week follow-up , TLFB results on the @ that continued methadone or the @ on Suboxone showed less opioid ( @ vs. @ % ; p < @ ) , illicit buprenorphine ( @ vs. @ % ; p = @ ) , benzodiazepine ( @ vs. @ % ; p < @ ) , and marijuana ( @ vs. @ % ; p < @ ) use than the @ who did not continue opioid substitution therapy .", "sentence_id": 5}
+{"abstract_id": "25456093", "label": "conclusions", "text": "Despite small but significant differences in opioid and other drug use , both treatments were highly effective in reducing opioid and non-opioid drug use .", "sentence_id": 6}
+{"abstract_id": "24773119", "label": "objective", "text": "To determine the effectiveness of an interactive educational intervention on a physiotherapy guideline for hip and knee osteoarthritis .", "sentence_id": 0}
+{"abstract_id": "24773119", "label": "methods", "text": "Physiotherapists were randomly allocated to a @-h interactive educational course with the collaboration of three patient partners or no intervention .", "sentence_id": 1}
+{"abstract_id": "24773119", "label": "methods", "text": "Assessments comprised questionnaires on adherence ( score range @-@ ) , knowledge ( score range @-@ ) , and barriers to use the guideline ( score range @-@ ) .", "sentence_id": 2}
+{"abstract_id": "24773119", "label": "methods", "text": "Assessments were conducted @ week before the interactive course ( T@ ) immediately after ( T@ ) , and @ months thereafter ( T@ ) .", "sentence_id": 3}
+{"abstract_id": "24773119", "label": "methods", "text": "Change scores were compared between the groups by means of Mann-Whitney U tests and linear mixed models .", "sentence_id": 4}
+{"abstract_id": "24773119", "label": "results", "text": "@ of @ eligible PTs ( @ % ) were included .", "sentence_id": 5}
+{"abstract_id": "24773119", "label": "results", "text": "The intervention ( n = @ ) was significantly more effective than no intervention ( n = @ ) concerning self-reported adherence and knowledge with mean differences in change scores ( @ % CI ) at T@ and T@ being @ ( @-@ @ ) and @ ( @-@ @ ) for adherence and @ ( @-@ @ ) and @ ( @-@ @ ) for knowledge , ( all p values < @ ) .", "sentence_id": 6}
+{"abstract_id": "24773119", "label": "results", "text": "In both groups the barrier score increased at T@ and decreased at T@ , with a significantly larger increase at T@ and decrease at T@ in the intervention group ( mean differences @ ( @-@ @ ) and @ ( @-@ @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "24773119", "label": "conclusions", "text": "A short interactive educational course with patient participation on a PT guideline on hip and knee osteoarthritis showed a small to moderate positive effect on self-reported guideline adherence and knowledge , whereas for perceived barriers an advantage was only seen on the longer term .", "sentence_id": 8}
+{"abstract_id": "25925415", "label": "background", "text": "Moderate , regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce .", "sentence_id": 0}
+{"abstract_id": "25925415", "label": "background", "text": "We evaluated the relations between wine consumption , health status , circulating biomarkers , and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial .", "sentence_id": 1}
+{"abstract_id": "25925415", "label": "results", "text": "A brief questionnaire on dietary habits was administered at baseline to @ patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell ` Insufficienza Cardiaca-Heart Failure ( GISSI-HF ) trial .", "sentence_id": 2}
+{"abstract_id": "25925415", "label": "results", "text": "The relations between wine consumption , fatal and nonfatal clinical end points , quality of life , symptoms of depression , and circulating biomarkers of cardiac function and inflammation ( in subsets of patients ) were evaluated with simple and multivariable-adjusted statistical models .", "sentence_id": 3}
+{"abstract_id": "25925415", "label": "results", "text": "Almost @ % of the patients reported drinking at least @ glass of wine per day .", "sentence_id": 4}
+{"abstract_id": "25925415", "label": "results", "text": "After adjustment , clinical outcomes were not significantly different in the predefined @ groups of wine consumption .", "sentence_id": 5}
+{"abstract_id": "25925415", "label": "results", "text": "However , patients with more frequent wine consumption had a significantly better perception of health status ( Kansas City Cardiomyopathy Questionnaire score , adjusted P < @ ) , less frequent symptoms of depression ( Geriatric Depression Scale , adjusted P = @ ) , and lower plasma levels of biomarkers of vascular inflammation ( osteoprotegerin and C-terminal proendothelin-@ , adjusted P < @ , and pentraxin-@ , P = @ ) after adjusting for possible confounders .", "sentence_id": 6}
+{"abstract_id": "25925415", "label": "conclusions", "text": "We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status , lower prevalence of depression , and less vascular inflammation , but does not translate into more favorable clinical @-year outcomes .", "sentence_id": 7}
+{"abstract_id": "25161024", "label": "background", "text": "Recent randomised controlled trials have compared the effects of albumin and hydroxyethyl starch ( HES ) v crystalloids on patient-centred outcomes in critically ill patients .", "sentence_id": 0}
+{"abstract_id": "25161024", "label": "background", "text": "The Saline v Albumin Fluid Evaluation ( SAFE ) trial reported patient-centred outcomes at @ days in @ patients assigned to fluid resuscitation with either @ % albumin or @ % saline ; the Crystalloid v Hydroxyethyl Starch Trial ( CHEST ) reported patient-centred outcomes at @ days in @ patients assigned to fluid resuscitation with either @ % HES ( @/@ @ ) or @ % saline .", "sentence_id": 1}
+{"abstract_id": "25161024", "label": "background", "text": "As the two trials used a common reference fluid ( @ % saline ) and had most trial methods and data collection points harmonised , a comparison of @ % albumin and @ % HES ( @/@ @ ) on patient-centred outcomes at @ days in critically ill patients using the individual patient data from the two trials is feasible .", "sentence_id": 2}
+{"abstract_id": "25161024", "label": "objective", "text": "To prepublish the statistical analysis plan ( SAP ) of an individual patient data comparative analysis of the SAFE and CHEST studies .", "sentence_id": 3}
+{"abstract_id": "25161024", "label": "methods", "text": "The statistical analyses are described in detail with the appropriate statistical analysis specified .", "sentence_id": 4}
+{"abstract_id": "25161024", "label": "results", "text": "The planned statistical analyses are described in detail for the SAFE and CHEST individual patient data comparative analysis .", "sentence_id": 5}
+{"abstract_id": "25161024", "label": "results", "text": "We outline the proposed statistical analysis for the baseline characteristics , processes of care and the outcomes .", "sentence_id": 6}
+{"abstract_id": "25161024", "label": "results", "text": "Subgroups are defined with statistical comparisons between the fluid groups and in each subgroup explained .", "sentence_id": 7}
+{"abstract_id": "25161024", "label": "conclusions", "text": "We have developed a SAP for the SAFE / CHEST individual patient data comparative analysis to increase the internal validity of the study and minimise bias .", "sentence_id": 8}
+{"abstract_id": "25449059", "label": "background", "text": "Studies have shown that tiotropium once daily reduces lung hyperinflation and dyspnea during exercise and improves exercise tolerance in patients with COPD .", "sentence_id": 0}
+{"abstract_id": "25449059", "label": "background", "text": "Mechanisms underlying the effects of the muscarinic receptor antagonist tiotropium on COPD have not been fully understood .", "sentence_id": 1}
+{"abstract_id": "25449059", "label": "objective", "text": "In this study , we investigated whether improvement in neural respiratory drive is responsible for reducing dyspnea during exercise and improving exercise tolerance in COPD .", "sentence_id": 2}
+{"abstract_id": "25449059", "label": "methods", "text": "Twenty subjects with severe COPD were randomized into two groups : no treatment ( Control , n = @ , @ years , FEV@ @ % pred ) or inhaled tiotropium @g once daily for @ month ( n = @ , @ years , FEV@ @ % pred ) .", "sentence_id": 3}
+{"abstract_id": "25449059", "label": "methods", "text": "All subjects were allowed to continue their daily medications other than anti-cholinergics during the study .", "sentence_id": 4}
+{"abstract_id": "25449059", "label": "methods", "text": "Constant cycle exercise with @ % of maximal workload and spirometry were performed before and @ month after treatment .", "sentence_id": 5}
+{"abstract_id": "25449059", "label": "methods", "text": "Diaphragmatic EMG ( EMGdi ) and respiratory pressures were recorded with multifunctional esophageal catheter .", "sentence_id": 6}
+{"abstract_id": "25449059", "label": "methods", "text": "Efficiency of neural respiratory drive , defined as the ratio of minute ventilation ( VE ) and diaphragmatic EMG ( VE/EMGdi % max ) , was calculated .", "sentence_id": 7}
+{"abstract_id": "25449059", "label": "methods", "text": "Modified British Medical Research Council Dyspnea Scale ( mMRC ) was used for the evaluation of dyspnea before and after treatment .", "sentence_id": 8}
+{"abstract_id": "25449059", "label": "results", "text": "There was no significant difference in spirometry before and after treatment in both groups .", "sentence_id": 9}
+{"abstract_id": "25449059", "label": "results", "text": "Diaphragmatic EMG decreased significantly at rest ( @ % vs. @ % , P < @ ) and mean efficiency of neural respiratory drive at the later stage of exercise increased ( @ vs. @ , P < @ ) after @-month treatment with tiotropium .", "sentence_id": 10}
+{"abstract_id": "25449059", "label": "results", "text": "There were no remarkable changes in resting EMGdi and mean efficiency of neural respiratory drive post-treatment in control group .", "sentence_id": 11}
+{"abstract_id": "25449059", "label": "results", "text": "The score of mMRC decreased significantly ( @ vs. @ , P < @ ) after @-month treatment with tiotropium , but without significantly difference in control group .", "sentence_id": 12}
+{"abstract_id": "25449059", "label": "conclusions", "text": "Tiotropium significantly reduces neural respiratory drive at rest and improves the efficiency of neural respiratory drive during exercise , which might account for the improvement in exercise tolerance in COPD .", "sentence_id": 13}
+{"abstract_id": "24378207", "label": "background", "text": "Combined treatment with a bisphosphonate and vitamin D has been proposed for postmenopausal osteoporosis .", "sentence_id": 0}
+{"abstract_id": "24378207", "label": "background", "text": "A new , fixed-dose combination tablet of ibandronate plus vitamin D@ has been developed for monthly administration to treat postmenopausal osteoporosis .", "sentence_id": 1}
+{"abstract_id": "24378207", "label": "objective", "text": "The main objective of the present study was to compare the pharmacokinetics of vitamin D@ administered in @ forms : a newly developed ibandronate @-mg/vitamin D@ @,@-IU tablet ( DP-R@ , test drug ) and a stand-alone vitamin D@ @,@-IU tablet ( reference drug ) .", "sentence_id": 2}
+{"abstract_id": "24378207", "label": "objective", "text": "A secondary objective was to evaluate the safety and tolerability of DP-R@ in healthy adult male Korean volunteers .", "sentence_id": 3}
+{"abstract_id": "24378207", "label": "methods", "text": "This study was a single-dose , open-label , randomized-sequence , @-treatment , @-way crossover trial .", "sentence_id": 4}
+{"abstract_id": "24378207", "label": "methods", "text": "Blood samples were collected from @ hours ' predose to @ hours ' postdose .", "sentence_id": 5}
+{"abstract_id": "24378207", "label": "methods", "text": "The plasma concentrations of vitamin D@ were analyzed by using a validated HPLC-MS/MS method .", "sentence_id": 6}
+{"abstract_id": "24378207", "label": "methods", "text": "Pharmacokinetic parameters were calculated , and the @ % CIs of the ratios of the geometric means of the parameters were determined from the logarithmically transformed data by using ANOVA .", "sentence_id": 7}
+{"abstract_id": "24378207", "label": "results", "text": "Thirty-sex healthy adult male Korean volunteers with a mean ( SD ) age of @ ( @ ) years , a mean height of @ ( @ ) cm , and a mean weight of @ ( @ ) kg were enrolled ; @ participants completed the study .", "sentence_id": 8}
+{"abstract_id": "24378207", "label": "results", "text": "The @ % CIs of the ratios of the geometric means ( test drug/reference drug ) of the baseline-corrected Cmax , AUC@-last , and AUC@ - values were @ to @ , @ to @ , and @ to @ , respectively .", "sentence_id": 9}
+{"abstract_id": "24378207", "label": "results", "text": "The @ % CIs of the ratios of the geometric means ( test drug/reference drug ) of the baseline-uncorrected Cmax , AUC@-last , and AUC@ - values were @ to @ , @ to @ , and @ to @ , respectively .", "sentence_id": 10}
+{"abstract_id": "24378207", "label": "results", "text": "Eighty-four adverse events ( AEs ) were reported in @ of @ subjects receiving DP-R@ , and @ AEs were reported in @ of @ subjects receiving the vitamin D@ @,@-IU tablet .", "sentence_id": 11}
+{"abstract_id": "24378207", "label": "results", "text": "All of the subjects who experienced AEs recovered without sequelae , and no serious AEs were observed .", "sentence_id": 12}
+{"abstract_id": "24378207", "label": "conclusions", "text": "The vitamin D@ pharmacokinetics were similar for DP-R@ and the @,@-IU vitamin D@ tablet .", "sentence_id": 13}
+{"abstract_id": "24378207", "label": "conclusions", "text": "DP-R@ was well tolerated .", "sentence_id": 14}
+{"abstract_id": "24952740", "label": "background", "text": "Care management interventions in the German health-care system have been evaluated with promising results , but further research is necessary to explore their full potential in the context of multi-morbidity .", "sentence_id": 0}
+{"abstract_id": "24952740", "label": "background", "text": "Our aim in this trial is to assess the efficacy of a primary care practice network-based care management intervention in improving self-care behaviour among patients with type @ diabetes mellitus and multiple co-occurring chronic conditions .", "sentence_id": 1}
+{"abstract_id": "24952740", "label": "methods", "text": "The study is designed as a prospective , @-month , multicentre , investigator-blinded , two-arm , open-label , individual-level , randomized parallel-group superiority trial .", "sentence_id": 2}
+{"abstract_id": "24952740", "label": "methods", "text": "We will enrol @ patients with type @ diabetes mellitus and at least two severe chronic conditions and one informal caregiver per patient .", "sentence_id": 3}
+{"abstract_id": "24952740", "label": "methods", "text": "Data will be collected at baseline ( T@ ) , at the primary endpoint after @months ( T@ ) and at follow-up after @months ( T@ ) .", "sentence_id": 4}
+{"abstract_id": "24952740", "label": "methods", "text": "The primary outcome will be the differences between the intervention and control groups in changes of diabetes-related self-care behaviours from baseline to T@ using a German version of the revised Summary of Diabetes Self-Care Activities ( SDSCA-G ) .", "sentence_id": 5}
+{"abstract_id": "24952740", "label": "methods", "text": "The secondary outcomes will be the differences between the intervention and control groups in : changes in scores on the SDSCA-G subscales , glycosylated haemoglobin A level , health-related quality of life , self-efficacy , differences in ( severe ) symptomatic hypoglycaemia , cost-effectiveness and financial family burden .", "sentence_id": 6}
+{"abstract_id": "24952740", "label": "methods", "text": "The intervention will be delivered by trained health-care assistants as an add-on to usual care and will consist of three main elements : ( @ ) three home visits , including structured assessment of medical and social needs ; ( @ ) @ structured telephone monitoring contacts ; and ( @ ) self-monitoring of blood glucose levels after T@ in @-month intervals .", "sentence_id": 7}
+{"abstract_id": "24952740", "label": "methods", "text": "The control group will receive usual care .", "sentence_id": 8}
+{"abstract_id": "24952740", "label": "methods", "text": "The confirmatory primary analysis will be performed following the intention-to-treat ( ITT ) principle .", "sentence_id": 9}
+{"abstract_id": "24952740", "label": "methods", "text": "The efficacy of the intervention will be quantified using two-level linear regression stratified by type of medical treatment adjusted for baseline values on the SDSCA-G .", "sentence_id": 10}
+{"abstract_id": "24952740", "label": "methods", "text": "Secondary analyses will be performed according to the ITT principle .", "sentence_id": 11}
+{"abstract_id": "24952740", "label": "methods", "text": "In health economic evaluations , we will estimate the incremental cost-effectiveness ratios .", "sentence_id": 12}
+{"abstract_id": "24952740", "label": "conclusions", "text": "We hope that the results of this study will provide insights into the efficacy of practice network-based care management among patients with complex health-care needs .", "sentence_id": 13}
+{"abstract_id": "24299521", "label": "objective", "text": "To determine if cats anaesthetised with alfaxalone have different recoveries to cats anaesthetised with a combination of ketamine and diazepam .", "sentence_id": 0}
+{"abstract_id": "24299521", "label": "methods", "text": "Anaesthesia for ovariohysterectomy was induced in cats with either alfaxalone ( n = @ ) or a combination of ketamine and diazepam ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24299521", "label": "methods", "text": "All cats were premedicated with combinations of acepromazine and morphine .", "sentence_id": 2}
+{"abstract_id": "24299521", "label": "methods", "text": "Recoveries were scored using a categorical grading scheme applied to @ parameters over @ minutes following extubation .", "sentence_id": 3}
+{"abstract_id": "24299521", "label": "methods", "text": "The parameters scored covered movement , sensitivity to touch , sound and light , body position , sneezing and vocalisation .", "sentence_id": 4}
+{"abstract_id": "24299521", "label": "methods", "text": "One person scored all recoveries and they were blinded to the induction drug used .", "sentence_id": 5}
+{"abstract_id": "24299521", "label": "methods", "text": "Scores were compared between drugs at different times using the Kruskal-Wallis rank sum test .", "sentence_id": 6}
+{"abstract_id": "24299521", "label": "results", "text": "Recovery scores were not normally distributed .", "sentence_id": 7}
+{"abstract_id": "24299521", "label": "results", "text": "Analysis of the data using the Kruskal-Wallis rank sum test revealed that cats induced with alfaxalone showed an increase in recovery scores at @ minutes for pawing at the head ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24299521", "label": "results", "text": "No parameters differed significantly at @ and @ minutes .", "sentence_id": 9}
+{"abstract_id": "24299521", "label": "results", "text": "For cats anaesthetised with ketamine and diazepam there was an increase at @ minutes in pacing , jerky sudden movements , unsettledness and increased sensitivity to touch at the surgical site and on the head ( p@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24299521", "label": "results", "text": "At @ minutes cats anaesthetised with ketamine and diazepam still showed an increase in unsettledness compared to those cats anaesthetised with alfaxalone ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24299521", "label": "conclusions", "text": "The results suggest that recoveries of cats following alfaxalone induction are significantly different to recoveries after induction with ketamine and diazepam .", "sentence_id": 12}
+{"abstract_id": "24299521", "label": "conclusions", "text": "Overall , cats induced with ketamine and diazepam had more active and unsettled recoveries than alfaxalone over the @-minute period observed .", "sentence_id": 13}
+{"abstract_id": "24299521", "label": "conclusions", "text": "Cats recovering from alfaxalone anaesthesia have more settled recoveries than cats recovering from ketamine and diazepam anaesthesia .", "sentence_id": 14}
+{"abstract_id": "24299521", "label": "conclusions", "text": "If a quiet settled recovery is desired following a surgical procedure , alfaxalone is likely to be a better choice than ketamine and diazepam .", "sentence_id": 15}
+{"abstract_id": "24997349", "label": "background", "text": "Psychosocial stress is accompanied by an increase in the activity of the hypothalamic-pituitary-adrenocortical ( HPA ) - axis and by an increase in food intake .", "sentence_id": 0}
+{"abstract_id": "24997349", "label": "background", "text": "At present , no studies have been conducted to examine the impact of a potent laboratory stress test on the chewing frequency .", "sentence_id": 1}
+{"abstract_id": "24997349", "label": "methods", "text": "Thirty-one healthy participants ( @ females , mean age @ ) were compared after they had fulfilled the protocol of a standardized psychosocial stress test , the Trier Social Stress Test ( TSST ) , and after a resting condition of silent reading in reference to their chewing frequency , chewing efficacy , food intake , and eating preferences .", "sentence_id": 2}
+{"abstract_id": "24997349", "label": "methods", "text": "As part of the design free salivary cortisol levels and heart rate variability were measured repeatedly before and after the TSST and the resting condition .", "sentence_id": 3}
+{"abstract_id": "24997349", "label": "results", "text": "After the TSST , the participants exhibited a significantly higher mean chewing frequency than after the resting condition ( F ( @,@ ) = @ , p = @ , ( @ ) = @ ) .", "sentence_id": 4}
+{"abstract_id": "24997349", "label": "results", "text": "The testing condition had no influence on the amount of food intake .", "sentence_id": 5}
+{"abstract_id": "24997349", "label": "results", "text": "Following the psychosocial stress , however , the participants reported a significantly less general appetite ( Z = -@ , p < @ ) and less of an appetite for eggs ( Z = -@ , p = @ ) than after their resting condition .", "sentence_id": 6}
+{"abstract_id": "24997349", "label": "results", "text": "No correlation was found between the salivary cortisol response and the chewing frequency .", "sentence_id": 7}
+{"abstract_id": "24997349", "label": "conclusions", "text": "The results indicated that psychosocial stress is associated with an increase in chewing frequency , as measured with a sound-based apparatus , and with a decrease in appetite .", "sentence_id": 8}
+{"abstract_id": "25872617", "label": "background", "text": "Health knowledge and literacy are among the main determinants of health .", "sentence_id": 0}
+{"abstract_id": "25872617", "label": "background", "text": "Assessment of these issues via Web-based surveys is growing continuously .", "sentence_id": 1}
+{"abstract_id": "25872617", "label": "background", "text": "Research has suggested that approximately one-fifth of respondents submit cribbed answers , or cheat , on factual knowledge items , which may lead to measurement error .", "sentence_id": 2}
+{"abstract_id": "25872617", "label": "background", "text": "However , little is known about methods of discouraging cheating in Web-based surveys on health knowledge .", "sentence_id": 3}
+{"abstract_id": "25872617", "label": "objective", "text": "This study aimed at exploring the usefulness of imposing a survey time limit to prevent help-seeking and cheating .", "sentence_id": 4}
+{"abstract_id": "25872617", "label": "methods", "text": "On the basis of sample size estimation , @ undergraduate students were randomly assigned in a @:@ ratio to complete a Web-based survey on nutrition knowledge , with or without a time limit of @ minutes ( @ seconds per item ) ; the topic of nutrition was chosen because of its particular relevance to public health .", "sentence_id": 5}
+{"abstract_id": "25872617", "label": "methods", "text": "The questionnaire consisted of two parts .", "sentence_id": 6}
+{"abstract_id": "25872617", "label": "methods", "text": "The first was the validated consumer-oriented nutrition knowledge scale ( CoNKS ) consisting of @ true/false items ; the second was an ad hoc questionnaire ( AHQ ) containing @ questions that would be very difficult for people without health care qualifications to answer correctly .", "sentence_id": 7}
+{"abstract_id": "25872617", "label": "methods", "text": "It therefore aimed at measuring cribbing and not nutrition knowledge .", "sentence_id": 8}
+{"abstract_id": "25872617", "label": "methods", "text": "AHQ items were somewhat encyclopedic and amenable to Web searching , while CoNKS items had more complex wording , so that simple copying/pasting of a question in a search string would not produce an immediate correct answer .", "sentence_id": 9}
+{"abstract_id": "25872617", "label": "results", "text": "A total of @ of the @ subjects started the survey .", "sentence_id": 10}
+{"abstract_id": "25872617", "label": "results", "text": "Dropout rates were similar in both groups ( @ % , @/@ and @ % , @/@ in the untimed and timed groups , respectively ) .", "sentence_id": 11}
+{"abstract_id": "25872617", "label": "results", "text": "Most participants completed the survey from portable devices , such as mobile phones and tablets .", "sentence_id": 12}
+{"abstract_id": "25872617", "label": "results", "text": "To complete the survey , participants in the untimed group took a median @ minutes longer than those in the timed group ; the effect size was small ( Cohen 's r = @ ) .", "sentence_id": 13}
+{"abstract_id": "25872617", "label": "results", "text": "Subjects in the untimed group scored significantly higher on CoNKS ( mean difference of @ points , P = @ ) and the effect size was medium ( Cohen 's d = @ ) .", "sentence_id": 14}
+{"abstract_id": "25872617", "label": "results", "text": "By contrast , no significant between-group difference in AHQ scores was documented .", "sentence_id": 15}
+{"abstract_id": "25872617", "label": "results", "text": "Unexpectedly high AHQ scores were recorded in @ % ( @/@ ) and @ % ( @/@ ) untimed and timed respondents , respectively , very probably owing to `` e-cheating '' .", "sentence_id": 16}
+{"abstract_id": "25872617", "label": "conclusions", "text": "Cribbing answers to health knowledge items in researcher-uncontrolled conditions is likely to lead to overestimation of people 's knowledge ; this should be considered during the design and implementation of Web-based surveys .", "sentence_id": 17}
+{"abstract_id": "25872617", "label": "conclusions", "text": "Setting a time limit alone may not completely prevent cheating , as some cheats may be very fast in Web searching .", "sentence_id": 18}
+{"abstract_id": "25872617", "label": "conclusions", "text": "More complex and contextualized wording of items and checking for the `` findability '' properties of items before implementing a Web-based health knowledge survey may discourage help-seeking , thus reducing measurement error .", "sentence_id": 19}
+{"abstract_id": "25872617", "label": "conclusions", "text": "Studies with larger sample sizes and diverse populations are needed to confirm our results .", "sentence_id": 20}
+{"abstract_id": "24915778", "label": "background", "text": "Trametinib , an oral mitogen/extracellular signal-related kinase ( MEK ) @/@ inhibitor , holds promise for malignancies with rat sarcoma ( RAS ) mutations , like pancreas cancer .", "sentence_id": 0}
+{"abstract_id": "24915778", "label": "background", "text": "This phase II study was designed to determine overall survival ( OS ) in patients with pancreas cancer treated with trametinib and gemcitabine .", "sentence_id": 1}
+{"abstract_id": "24915778", "label": "background", "text": "Secondary end-points included progression-free survival ( PFS ) , overall response rate ( ORR ) and duration of response ( DOR ) ; safety end-points were also assessed .", "sentence_id": 2}
+{"abstract_id": "24915778", "label": "methods", "text": "Adults with untreated metastatic adenocarcinoma of the pancreas were randomised ( @:@ ) to receive intravenous gemcitabine @ mg/m ( @ ) ( weekly @ for @ weeks , then days @ , @ and @ of @-day cycles ) plus trametinib or placebo @mg daily .", "sentence_id": 3}
+{"abstract_id": "24915778", "label": "methods", "text": "RAS mutations were determined in circulating free DNA ( cfDNA ) and archival tumour tissue .", "sentence_id": 4}
+{"abstract_id": "24915778", "label": "methods", "text": "OS was evaluated in kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutant and wild-type subgroups .", "sentence_id": 5}
+{"abstract_id": "24915778", "label": "results", "text": "Baseline characteristics for @ patients were similar in both treatment arms .", "sentence_id": 6}
+{"abstract_id": "24915778", "label": "results", "text": "There was no significant difference in OS ( hazard ratio ( HR ) @ ; @ % confidence interval ( CI ) , @-@ @ ; P = @ ) ; median OS was @ months with gemcitabine plus trametinib and @ months with gemcitabine plus placebo .", "sentence_id": 7}
+{"abstract_id": "24915778", "label": "results", "text": "Median PFS ( @ versus @ weeks ) , ORR ( @ % versus @ % ) and median DOR ( @ versus @ weeks ) were also similar for trametinib and placebo arms , respectively .", "sentence_id": 8}
+{"abstract_id": "24915778", "label": "results", "text": "KRAS mutation-positive patients ( n = @ ) showed no difference in OS between arms .", "sentence_id": 9}
+{"abstract_id": "24915778", "label": "results", "text": "Thrombocytopenia , diarrhoea , rash and stomatitis were more frequent with trametinib , as was grade @ anaemia .", "sentence_id": 10}
+{"abstract_id": "24915778", "label": "conclusions", "text": "The addition of trametinib to gemcitabine did not improve OS , PFS , ORR or DOR in patients with previously untreated metastatic pancreas cancer .", "sentence_id": 11}
+{"abstract_id": "24915778", "label": "conclusions", "text": "Outcomes were independent of KRAS mutations determined by cfDNA .", "sentence_id": 12}
+{"abstract_id": "26182759", "label": "background", "text": "Transurethral resection of prostate ( TURP ) is considered the gold standard for the surgical treatment of BPH .", "sentence_id": 0}
+{"abstract_id": "26182759", "label": "background", "text": "Irrigant fluid absorption by the patient is a potentially serious complication of TURP and can lead to dilutional hyponatremia and TURP syndrome .", "sentence_id": 1}
+{"abstract_id": "26182759", "label": "background", "text": "Other common complications of TURP include urinary tract infection and secondary haemorrhage .", "sentence_id": 2}
+{"abstract_id": "26182759", "label": "background", "text": "The objective of this study was to compare the frequency of postoperative complications ( Urinary Tract infection and dilutional hyponatremia ) between @ % glycine and sterile distilled water used as irrigant in BPH patients after TURP .", "sentence_id": 3}
+{"abstract_id": "26182759", "label": "methods", "text": "This randomized controlled trial was conducted in department of Urology , PIMS Islamabad , from August @ to February @ .", "sentence_id": 4}
+{"abstract_id": "26182759", "label": "methods", "text": "A total of @ adult male patients between @-@ years of age undergoing TURP with prostate volume more than @cc on ultrasound .", "sentence_id": 5}
+{"abstract_id": "26182759", "label": "methods", "text": "@ patients each were randomly allocated to two groups .", "sentence_id": 6}
+{"abstract_id": "26182759", "label": "methods", "text": "In group-A , glycine was used as irrigan , t solution during TURP while in group-B distilled water was used .", "sentence_id": 7}
+{"abstract_id": "26182759", "label": "methods", "text": "Serum sodium levels were measured at @th postoperative hour to look for dilutional hyponatremia .", "sentence_id": 8}
+{"abstract_id": "26182759", "label": "methods", "text": "On the @th postoperative day they were inquired about any clinical features of urinary tract infection .", "sentence_id": 9}
+{"abstract_id": "26182759", "label": "methods", "text": "Also urine routine examination was performed to look for the presence of WBCs in the urine .", "sentence_id": 10}
+{"abstract_id": "26182759", "label": "results", "text": "Post-operative dilutional hyponatremia was observed in @ ( @ % ) patients in Group A and in @ ( @ % ) patients in group-B .", "sentence_id": 11}
+{"abstract_id": "26182759", "label": "results", "text": "The difference between both the groups being nonsignificant ( p-value = @ ) .", "sentence_id": 12}
+{"abstract_id": "26182759", "label": "results", "text": "Frequency of postoperative urinary tract infection on @th postoperative day in group-A was @ ( @ % ) while in group-B it was @ ( @ % ) , the difference among both the groups being insignificant ( p-value = @ ) .", "sentence_id": 13}
+{"abstract_id": "26182759", "label": "conclusions", "text": "Although the frequency of postoperative complications like UTI and dilutional hyponatremia was less with sterile distilled water , yet , the difference was statistically not significant .", "sentence_id": 14}
+{"abstract_id": "24298995", "label": "objective", "text": "To compare efficacy and safety of two , once-daily basal insulin formulations -LSB- insulin lispro protamine suspension ( ILPS ) vs. insulin glargine ( glargine ) -RSB- added to oral antihyperglycaemic medications ( OAMs ) and exenatide BID in suboptimally controlled type @ diabetes ( T@D ) patients .", "sentence_id": 0}
+{"abstract_id": "24298995", "label": "methods", "text": "This @-week , open-label , multicentre trial randomized patients to bedtime ILPS ( n = @ ) or glargine ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24298995", "label": "methods", "text": "Non-inferiority of ILPS versus glargine was assessed by comparing the upper limit of @ % confidence intervals ( CIs ) for change in haemoglobin A@c ( HbA@c ) from baseline to week @ ( adjusted for baseline HbA@c ) with non-inferiority margin @ % .", "sentence_id": 2}
+{"abstract_id": "24298995", "label": "results", "text": "Non-inferiority of ILPS versus glargine was demonstrated : least-squares mean between-treatment difference ( ILPS minus glargine ) ( @ % CI ) was @ % ( @ , @ ) .", "sentence_id": 3}
+{"abstract_id": "24298995", "label": "results", "text": "Mean HbA@c reduction was less for ILPS - versus glargine-treated patients ( -@ vs. -@ % , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24298995", "label": "results", "text": "Endpoint HbA@c < @ % was achieved by @ % ( ILPS ) and @ % ( glargine ) ( p = NS ) .", "sentence_id": 5}
+{"abstract_id": "24298995", "label": "results", "text": "Overall hypoglycaemia rates ( p = NS ) and severe hypoglycaemia incidence ( p = NS ) were similar .", "sentence_id": 6}
+{"abstract_id": "24298995", "label": "results", "text": "Nocturnal hypoglycaemia rate was higher in patients treated with ILPS versus glargine ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24298995", "label": "results", "text": "Weight gain was similar between groups ( ILPS : @ kg ; glargine : @ kg , p = NS ) .", "sentence_id": 8}
+{"abstract_id": "24298995", "label": "results", "text": "Endpoint total insulin doses were lower in patients treated with ILPS versus glargine ( @ vs. @ IU/kg/day , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24298995", "label": "conclusions", "text": "ILPS was non-inferior to glargine for HbA@c change over @weeks , but was associated with less HbA@c reduction and more nocturnal hypoglycaemia .", "sentence_id": 10}
+{"abstract_id": "24298995", "label": "conclusions", "text": "Treat-to-target basal insulin therapy improves glycaemic control and is associated with minimal weight gain when added to OAMs and exenatide BID for suboptimally controlled T@D .", "sentence_id": 11}
+{"abstract_id": "24820395", "label": "background", "text": "Cerebral blood flow velocity ( CBFV ) measured by transcranial Doppler sonography has provided information on cerebral perfusion in patients undergoing infant heart surgery , but no studies have reported a relationship to early postoperative and long-term neurodevelopmental outcomes .", "sentence_id": 0}
+{"abstract_id": "24820395", "label": "methods", "text": "CBFV was measured in infants undergoing biventricular repair without aortic arch reconstruction as part of a trial of hemodilution during cardiopulmonary bypass ( CPB ) ; CBFV ( Vm , mean ; Vs , systolic ; Vd , end-diastolic ) in the middle cerebral artery and change in Vm ( rVm ) were measured intraoperatively and up to @ hours post-CPB .", "sentence_id": 1}
+{"abstract_id": "24820395", "label": "methods", "text": "Neurodevelopmental outcomes , measured at @ year of age , included the psychomotor development index ( PDI ) and mental development index ( MDI ) of the Bayley Scales of Infant Development-II .", "sentence_id": 2}
+{"abstract_id": "24820395", "label": "results", "text": "CBFV was measured in @ infants ; @ with D-transposition of the great arteries , @ with tetralogy of Fallot , and @ with ventricular septal defects .", "sentence_id": 3}
+{"abstract_id": "24820395", "label": "results", "text": "Lower Vm , Vs , Vd , and rVm at @ hours post-CPB were independently related to longer intensive care unit duration of stay ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24820395", "label": "results", "text": "In the @ patients who returned for neurodevelopmental testing , lower Vm , Vs , Vd , and rVm at @ hours post-CPB were independently associated with lower PDI ( p < @ ) and MDI ( p < @ , except Vs : p = @ ) scores .", "sentence_id": 5}
+{"abstract_id": "24820395", "label": "results", "text": "Higher Vs and rVm at @ hours post-CPB were independently associated with increased incidence of brain injury on magnetic resonance imaging in @ patients .", "sentence_id": 6}
+{"abstract_id": "24820395", "label": "conclusions", "text": "Postoperative CBFV after biventricular repair is related to early postoperative and neurodevelopmental outcomes at @ year of age , possibly indicating that low CBFV is a marker of suboptimal postoperative hemodynamics and cerebral perfusion .", "sentence_id": 7}
+{"abstract_id": "25212234", "label": "objective", "text": "Patients with acute coronary syndromes ( ACS ) display diffuse coronary atheroma instability and heightened risk of early and late recurrent coronary events .", "sentence_id": 0}
+{"abstract_id": "25212234", "label": "objective", "text": "We compared the long-term antiatherosclerotic efficacy of high-intensity statins in patients with ACS when compared with stable disease .", "sentence_id": 1}
+{"abstract_id": "25212234", "label": "results", "text": "Study of Coronary Atheroma by Intravascular Ultrasound : Effect of Rosuvastatin Versus Atorvastatin ( SATURN ) used serial intravascular ultrasound measures of coronary atheroma volume in patients treated with rosuvastatin @ mg or atorvastatin @ mg for @ months .", "sentence_id": 2}
+{"abstract_id": "25212234", "label": "results", "text": "The overall effect of high-intensity statins on the change in coronary percent atheroma volume and major adverse cardiovascular events ( death/nonfatal myocardial infarction/coronary revascularization ) were evaluated in this post hoc analysis .", "sentence_id": 3}
+{"abstract_id": "25212234", "label": "results", "text": "When compared with non-ACS patients ( n = @ ) , patients with ACS ( n = @ ) were younger , actively smoking , and have had a previous myocardial infarction ( all P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25212234", "label": "results", "text": "At baseline , patients with ACS exhibited lower high-density lipoprotein cholesterol ( @ versus @ mg/dL ; P = @ ) , a higher apolipoprotein B : apolipoprotein A-@ ratio ( @ versus @ ; P < @ ) and greater percent atheroma volume ( @ % versus @ % ; P = @ ) when compared with non-ACS patients .", "sentence_id": 5}
+{"abstract_id": "25212234", "label": "results", "text": "Despite similar achieved levels of lipid and inflammatory markers after high-intensity statin therapy , patients with ACS demonstrated greater percent atheroma volume regression than non-ACS patients ( -@ versus -@ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25212234", "label": "results", "text": "After propensity-weighted multivariable adjustment , baseline percent atheroma volume ( P < @ ) and an ACS clinical presentation ( P = @ ) independently associated with plaque regression .", "sentence_id": 7}
+{"abstract_id": "25212234", "label": "results", "text": "The @-month major adverse cardiovascular events-free survival was similar between patients with ACS and non-ACS ( @ versus @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25212234", "label": "conclusions", "text": "Long-term high-intensity statin therapy caused greater plaque regression and comparable major adverse cardiovascular events rates in ACS when compared with non-ACS patients .", "sentence_id": 9}
+{"abstract_id": "25212234", "label": "conclusions", "text": "Despite a higher clinical risk profile , patients with ACS harbor a more modifiable disease substrate and seem to benefit the most from potent statin therapy .", "sentence_id": 10}
+{"abstract_id": "24963091", "label": "objective", "text": "Beside traditional dysphagia therapy , neuromuscular electrical stimulation ( NMES ) has been proposed to treat patients with dysphagia .", "sentence_id": 0}
+{"abstract_id": "24963091", "label": "objective", "text": "Considering the complexity of the nerve-muscle interaction during swallowing , the underlying physiology of NMES remains unclear .", "sentence_id": 1}
+{"abstract_id": "24963091", "label": "objective", "text": "Here , we addressed the question of whether NMES can modify upper esophageal sphincter ( UES ) dynamics .", "sentence_id": 2}
+{"abstract_id": "24963091", "label": "methods", "text": "In a prospective study , @ healthy volunteers performed water swallows with and without NMES .", "sentence_id": 3}
+{"abstract_id": "24963091", "label": "methods", "text": "The stimulus was applied in a participant - and operator-initiated stimulation above , near , and below the motor threshold .", "sentence_id": 4}
+{"abstract_id": "24963091", "label": "methods", "text": "Swallowing parameters were measured using high-resolution manometry .", "sentence_id": 5}
+{"abstract_id": "24963091", "label": "results", "text": "The UES relaxation time was found to be extended by @ % , indicating a modification in UES dynamics .", "sentence_id": 6}
+{"abstract_id": "24963091", "label": "conclusions", "text": "The chosen NMES paradigm influenced the involuntary swallowing phase by extending relaxation time , providing more time for bolus passage into the esophagus .", "sentence_id": 7}
+{"abstract_id": "24963091", "label": "conclusions", "text": "Future studies will have to evaluate if this effect can be found in patients with dysphagia and whether it is beneficial for treatment .", "sentence_id": 8}
+{"abstract_id": "25216962", "label": "objective", "text": "Aim of this prospective study was to investigate the effectiveness of eutectic mixture of local anaesthetic ( EMLA ) patches on every abdominal incision for pain relief after gynaecologic laparoscopic surgery .", "sentence_id": 0}
+{"abstract_id": "25216962", "label": "methods", "text": "A total of @ women were prospectively randomised to receive either placebo ( control group ) or EMLA ( study group ) patches on all abdominal incisions .", "sentence_id": 1}
+{"abstract_id": "25216962", "label": "methods", "text": "Postoperative pain was assessed @ and @ h after surgery using the short form of the McGill Pain Questionnaire ( SF-MPQ ) .", "sentence_id": 2}
+{"abstract_id": "25216962", "label": "methods", "text": "The amount of analgesic pain medication on demand was assessed in both groups .", "sentence_id": 3}
+{"abstract_id": "25216962", "label": "results", "text": "Sixty women were allocated to the study group and @ patients to the control group before laparoscopic surgery .", "sentence_id": 4}
+{"abstract_id": "25216962", "label": "results", "text": "There were no statistically significant differences regarding age , body mass index ( BMI ) , duration of surgery and blood loss comparing both groups .", "sentence_id": 5}
+{"abstract_id": "25216962", "label": "results", "text": "There were no statistically significant differences between both groups with regard to postoperative total pain scores @ h ( McGill total score : @ @ vs. @ @ , p = @ ) and @ h ( McGill total score : @ @ vs. @ @ , p = @ ) after surgery .", "sentence_id": 6}
+{"abstract_id": "25216962", "label": "results", "text": "Time to mobilisation after surgery ( hours ) was significantly shorter in the study group ( @ @ vs. @ @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25216962", "label": "conclusions", "text": "Despite of a significant reduction of time for mobilisation transdermal anaesthetic patches after gynaecologic laparoscopic surgery did not lead to decreased postoperative pain scores .", "sentence_id": 8}
+{"abstract_id": "24225356", "label": "background", "text": "Haiti has experienced rapid urbanization that has exacerbated poverty and undernutrition in large slum areas .", "sentence_id": 0}
+{"abstract_id": "24225356", "label": "background", "text": "Stunting affects @ in @ young children .", "sentence_id": 1}
+{"abstract_id": "24225356", "label": "objective", "text": "We aimed to test the efficacy of a daily lipid-based nutrient supplement ( LNS ) for increased linear growth in young children .", "sentence_id": 2}
+{"abstract_id": "24225356", "label": "methods", "text": "Healthy , singleton infants aged @-@ mo ( n = @ ) were recruited from an urban slum of Cap Haitien and randomly assigned to receive : @ ) a control ; @ ) a @-mo LNS ; or @ ) a @-mo LNS .", "sentence_id": 3}
+{"abstract_id": "24225356", "label": "methods", "text": "The LNS provided @ kcal and other nutrients including vitamin A , vitamin B-@ , iron , and zinc at @ % of the recommended amounts .", "sentence_id": 4}
+{"abstract_id": "24225356", "label": "methods", "text": "Infants were followed monthly on growth , morbidity , and developmental outcomes over a @-mo intervention period and at one additional time point @ mo postintervention to assess sustained effects .", "sentence_id": 5}
+{"abstract_id": "24225356", "label": "methods", "text": "The Bonferroni multiple comparisons test was applied , and generalized least-squares ( GLS ) regressions with mixed effects was used to examine impacts longitudinally .", "sentence_id": 6}
+{"abstract_id": "24225356", "label": "results", "text": "Baseline characteristics did not differ by trial arm except for a higher mean age in the @-mo LNS group .", "sentence_id": 7}
+{"abstract_id": "24225356", "label": "results", "text": "GLS modeling showed LNS supplementation for @ mo significantly increased the length-for-age z score ( SE ) by @ @ and the weight-for-age z score by @ @ compared with in the control group after adjustment for child age ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24225356", "label": "results", "text": "The effects were sustained @ mo postintervention .", "sentence_id": 9}
+{"abstract_id": "24225356", "label": "results", "text": "Morbidity and developmental outcomes did not differ by trial arm .", "sentence_id": 10}
+{"abstract_id": "24225356", "label": "conclusions", "text": "A low-energy , fortified product improved the linear growth of young children in this urban setting .", "sentence_id": 11}
+{"abstract_id": "24225356", "label": "conclusions", "text": "The trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 12}
+{"abstract_id": "25048382", "label": "objective", "text": "Blood pressure ( BP ) control for renal protection is essential for patients with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25048382", "label": "objective", "text": "Our objective in this analysis of Veterans Affairs Diabetes Trial ( VADT ) data was to learn whether on-study systolic BP ( SBP ) , diastolic BP ( DBP ) , and pulse pressure ( PP ) affected renal outcomes measured as albumin-to-creatinine ratio ( ACR ) and estimated glomerular filtration rate ( eGFR ) .", "sentence_id": 1}
+{"abstract_id": "25048382", "label": "methods", "text": "The VADT was a prospective , randomized study of @,@ veterans with type @ diabetes to determine whether intensive glucose control prevented major cardiovascular events .", "sentence_id": 2}
+{"abstract_id": "25048382", "label": "methods", "text": "In this post hoc study , time-varying covariate survival analyses and hazard ratios ( HR ) were used to determine worsening of renal outcomes .", "sentence_id": 3}
+{"abstract_id": "25048382", "label": "results", "text": "Compared with SBP @-@ mmHg , the risk of ACR worsening increased significantly for SBP @-@ mmHg ( HR @ -LSB- @ % CI @-@ @ -RSB- ; P = @ ) and for SBP @ mmHg ( @ -LSB- @-@ @ -RSB- ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25048382", "label": "results", "text": "Compared with a PP range of @-@ mmHg , PP < @ was associated with significantly lowered risk of worsening ACR ( @ -LSB- @-@ @ -RSB- ; P = @ ) and PP @ with significantly increased risk ( @ -LSB- @-@ @ -RSB- ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25048382", "label": "results", "text": "Analyses of BP ranges associated with eGFR worsening showed significantly increased risk with rising baseline SBP and an interaction effect between SBP @ mmHg and on-study A@C .", "sentence_id": 6}
+{"abstract_id": "25048382", "label": "results", "text": "These patients were @ % more likely than those with SBP < @ mmHg to experience eGFR worsening ( @ -LSB- @-@ @ -RSB- ; P = @ ) for each @ % ( @ mmol/mol ) A@C increase .", "sentence_id": 7}
+{"abstract_id": "25048382", "label": "conclusions", "text": "SBP @ mmHg and PP > @ mmHg were associated with worsening ACR .", "sentence_id": 8}
+{"abstract_id": "25048382", "label": "conclusions", "text": "The results suggest that treatment of SBP to < @ mmHg may lessen ACR worsening .", "sentence_id": 9}
+{"abstract_id": "25048382", "label": "conclusions", "text": "The interaction between SBP @ mmHg and A@C suggests that the effect of glycemic control on reducing progression of renal disease may be greater in hypertensive patients .", "sentence_id": 10}
+{"abstract_id": "25072616", "label": "background", "text": "Protease inhibitor-based antiretroviral therapy ( ART ) has been associated with preterm birth in some studies .", "sentence_id": 0}
+{"abstract_id": "25072616", "label": "background", "text": "We examined risk factors for preterm birth among women randomized to lopinavir/ritonavir ( LPV/r ) - or efavirenz ( EFV ) - based ART .", "sentence_id": 1}
+{"abstract_id": "25072616", "label": "methods", "text": "This was a planned secondary analysis of the PROMOTE-Pregnant Women and Infants Study , an open-label , randomized controlled trial comparing the risk of placental malaria among HIV-infected , ART-naive pregnant Ugandan women assigned to initiate LPV/r - or EFV-based ART at @-@ weeks gestation .", "sentence_id": 2}
+{"abstract_id": "25072616", "label": "methods", "text": "Gestational age was determined based on last menstrual period and ultrasound biometry .", "sentence_id": 3}
+{"abstract_id": "25072616", "label": "methods", "text": "All women received bednets and trimethoprim-sulfamethoxazole .", "sentence_id": 4}
+{"abstract_id": "25072616", "label": "methods", "text": "Stillbirths , spontaneous abortions , and multiple gestations were excluded from the primary analysis .", "sentence_id": 5}
+{"abstract_id": "25072616", "label": "methods", "text": "Potential risk factors for preterm birth ( < @ weeks gestation ) were evaluated by univariate and multivariate logistic regression .", "sentence_id": 6}
+{"abstract_id": "25072616", "label": "results", "text": "Three hundred fifty-six women were included in this analysis .", "sentence_id": 7}
+{"abstract_id": "25072616", "label": "results", "text": "At enrollment , median gestational age was @ weeks and median CD@ cell count was @ cells per cubic millimeter .", "sentence_id": 8}
+{"abstract_id": "25072616", "label": "results", "text": "@ % of deliveries in the EFV arm and @ % in the LPV/r arm were preterm .", "sentence_id": 9}
+{"abstract_id": "25072616", "label": "results", "text": "Preterm birth was associated with gestational weight gain below @ kg/week versus @ kg/week or more -LSB- odds ratio ( OR ) = @ ; @ % confidence interval ( CI ) : @ to @ ; P = @ -RSB- .", "sentence_id": 10}
+{"abstract_id": "25072616", "label": "results", "text": "Neither ART regimen of LPV/r versus EFV ( OR = @ ; @ % CI : @ to @ ; P = @ ) nor placental malaria ( OR = @ ; @ % CI : @ to @ ; P = @ ) was associated with preterm birth .", "sentence_id": 11}
+{"abstract_id": "25072616", "label": "conclusions", "text": "LPV/r was not associated with an increased risk of preterm birth compared with EFV .", "sentence_id": 12}
+{"abstract_id": "25072616", "label": "conclusions", "text": "However , interventions are needed to address modifiable risk factors for preterm birth , such as nutritional status ( ClinicalTrials.gov , NCT@ ) .", "sentence_id": 13}
+{"abstract_id": "24628987", "label": "background", "text": "The optimal substrate ablation approach in patients with persistent atrial fibrillation ( Per AF ) remains unclear .", "sentence_id": 0}
+{"abstract_id": "24628987", "label": "background", "text": "This was a prospective randomized study comparing the efficacy of limited ( continuous complex fractionated atrial electrogram , CFAE : < @ milliseconds ) versus extensive ( continuous CFAE plus variable CFAE : < @ milliseconds ) atrial substrate modification in Per AF patients .", "sentence_id": 1}
+{"abstract_id": "24628987", "label": "results", "text": "We enrolled @ Per AF patients in the study , and @ patients with AF termination after pulmonary vein isolation ( PVI ) were excluded .", "sentence_id": 2}
+{"abstract_id": "24628987", "label": "results", "text": "In the remaining @ patients , @ were treated with limited approach ( Group @ ) and @ with an extensive approach ( Group @ ) .", "sentence_id": 3}
+{"abstract_id": "24628987", "label": "results", "text": "The end point of the study was the incidence of an atrial arrhythmia recurrence postblanking period .", "sentence_id": 4}
+{"abstract_id": "24628987", "label": "results", "text": "The patients were followed up for @ months with @-month clinical reviews , electrograms ( ECGs ) , Holter recordings , and echocardiographic monitoring .", "sentence_id": 5}
+{"abstract_id": "24628987", "label": "results", "text": "Procedural AF termination and the single procedural efficacy were statistically comparable between the @ groups ( @ % vs. @ % in Groups @ and @ , respectively , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24628987", "label": "results", "text": "During the follow-up , patients who received limited ablation had a lower incidence of recurrent AFL ( P = @ ) , and better reverse remodeling of the left atrium ( LA , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24628987", "label": "results", "text": "After @ procedures , the freedom from any atrial arrhythmia was better in Group @ ( @ % vs. @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24628987", "label": "results", "text": "Those with longstanding AF and a larger baseline LA size responded better to the extensive ablation .", "sentence_id": 9}
+{"abstract_id": "24628987", "label": "conclusions", "text": "In the Per AF patients who failed to achieve AF termination after PVI alone , a specific atrial substrate modification approach targeting only continuous CFAEs could be considered as an initial ablation strategy .", "sentence_id": 10}
+{"abstract_id": "25179672", "label": "background", "text": "Alcohol misuse among military service members from the recent conflicts in Iraq and Afghanistan is over two times higher compared to misuse in the civilian population .", "sentence_id": 0}
+{"abstract_id": "25179672", "label": "background", "text": "Unfortunately , in addition to experiencing personal consequences from alcohol misuse , partners and family members of alcohol-misusing service members also suffer in negative ways from their loved one 's drinking .", "sentence_id": 1}
+{"abstract_id": "25179672", "label": "background", "text": "These family members represent important catalysts for helping their loved ones identify problem drinking and overcoming the barriers to seeking care .", "sentence_id": 2}
+{"abstract_id": "25179672", "label": "background", "text": "This paper describes the protocol to a pilot study evaluating a @-session , web-based intervention ( WBI ) for concerned partners ( CPs ) of service members with alcohol misuse .", "sentence_id": 3}
+{"abstract_id": "25179672", "label": "methods", "text": "The WBI will be adapted from the Community Reinforcement and Family Training ( CRAFT ) intervention .", "sentence_id": 4}
+{"abstract_id": "25179672", "label": "methods", "text": "In the first phase , we will develop and beta-test the WBI with @-@ CPs .", "sentence_id": 5}
+{"abstract_id": "25179672", "label": "methods", "text": "In the second phase , we will randomize CPs to WBI ( n = @ ) or to delayed-WBI ( n = @ ) and evaluate the impact of the WBI on CPs ' perceptions of service member help-seeking and drinking , as well as the CP 's well-being and relationship satisfaction @months after the intervention .", "sentence_id": 6}
+{"abstract_id": "25179672", "label": "methods", "text": "In the third phase , we will recruit @-@ service members whose partners have completed the study .", "sentence_id": 7}
+{"abstract_id": "25179672", "label": "methods", "text": "We will interview the service members to learn how the CP-focused WBI affected them and to assess whether they would be receptive to a follow-on WBI module to help them .", "sentence_id": 8}
+{"abstract_id": "25179672", "label": "conclusions", "text": "This project has the potential to benefit a large population of military service members who may be disproportionately affected by recent conflicts and whose drinking misuse would otherwise go undetected and untreated .", "sentence_id": 9}
+{"abstract_id": "25179672", "label": "conclusions", "text": "It also develops a new prevention model that does not rely on service members or partners attending a hospital or clinical facility to access care .", "sentence_id": 10}
+{"abstract_id": "25134858", "label": "objective", "text": "To identify predictive factors associated with the development of pressure ulcers in patients at risk who receive standardized preventive care .", "sentence_id": 0}
+{"abstract_id": "25134858", "label": "background", "text": "Numerous studies have examined factors that predict risk for pressure ulcer development .", "sentence_id": 1}
+{"abstract_id": "25134858", "label": "background", "text": "Only a few studies identified risk factors associated with pressure ulcer development in hospitalized patients receiving standardized preventive care .", "sentence_id": 2}
+{"abstract_id": "25134858", "label": "methods", "text": "Secondary analyses of data collected in a multicentre randomized controlled trial .", "sentence_id": 3}
+{"abstract_id": "25134858", "label": "methods", "text": "The sample consisted of @ consecutive patients at risk for pressure ulcer development ( Braden Score < @ ) receiving standardized preventive care measures .", "sentence_id": 4}
+{"abstract_id": "25134858", "label": "methods", "text": "Patient demographic information , data on skin and risk assessment , medical history and diagnosis were collected during @months ( December @-January @ ) .", "sentence_id": 5}
+{"abstract_id": "25134858", "label": "methods", "text": "Predictive factors were identified using multivariate statistics .", "sentence_id": 6}
+{"abstract_id": "25134858", "label": "results", "text": "Pressure ulcers in category II-IV were significantly associated with non-blanchable erythema , urogenital disorders and higher body temperature .", "sentence_id": 7}
+{"abstract_id": "25134858", "label": "results", "text": "Predictive factors significantly associated with superficial pressure ulcers were admission to an internal medicine ward , incontinence-associated dermatitis , non-blanchable erythema and a lower Braden score .", "sentence_id": 8}
+{"abstract_id": "25134858", "label": "results", "text": "Superficial sacral pressure ulcers were significantly associated with incontinence-associated dermatitis .", "sentence_id": 9}
+{"abstract_id": "25134858", "label": "conclusions", "text": "Despite the standardized preventive measures they received , hospitalized patients with non-blanchable erythema , urogenital disorders and a higher body temperature were at increased risk for developing pressure ulcers .", "sentence_id": 10}
+{"abstract_id": "25134858", "label": "conclusions", "text": "Improved identification of at-risk patients can be achieved by taking into account specific predictive factors .", "sentence_id": 11}
+{"abstract_id": "25134858", "label": "conclusions", "text": "Even if preventive measures are in place , continuous assessment and tailoring of interventions is necessary in all patients at risk .", "sentence_id": 12}
+{"abstract_id": "25134858", "label": "conclusions", "text": "Daily skin observation can be used to continuously monitor the effectiveness of the intervention .", "sentence_id": 13}
+{"abstract_id": "24581596", "label": "objective", "text": "The use of liver as a reference tissue for semi-quantification of tumour FDG uptake may not be valid in hepatic steatosis ( HS ) .", "sentence_id": 0}
+{"abstract_id": "24581596", "label": "objective", "text": "Previous studies on the relation between liver FDG uptake and HS have been contradictory probably because they ignored blood glucose ( BG ) .", "sentence_id": 1}
+{"abstract_id": "24581596", "label": "objective", "text": "Because hepatocyte and blood FDG concentrations equalize , liver FDG uptake parallels BG , which must therefore be considered when studying hepatic FDG uptake .", "sentence_id": 2}
+{"abstract_id": "24581596", "label": "objective", "text": "We therefore re-examined the relation between HS and liver uptake taking BG into account .", "sentence_id": 3}
+{"abstract_id": "24581596", "label": "methods", "text": "This was a retrospective study of @ patients undergoing routine PET/CT with imaging @min post-FDG .", "sentence_id": 4}
+{"abstract_id": "24581596", "label": "methods", "text": "Average standard uptake value ( SUVave ) , maximum SUV ( SUVmax ) and CT density ( index of HS ) were measured in a liver ROI .", "sentence_id": 5}
+{"abstract_id": "24581596", "label": "methods", "text": "Blood pool SUV was based on the left ventricular cavity ( SUVLV ) .", "sentence_id": 6}
+{"abstract_id": "24581596", "label": "methods", "text": "Correlations were assessed using least squares fitting of continuous data .", "sentence_id": 7}
+{"abstract_id": "24581596", "label": "methods", "text": "Patients were also divided into BG subgroups ( < @ , @-@ , @-@ , @-@ , @-@ and @ + mmol/l ) .", "sentence_id": 8}
+{"abstract_id": "24581596", "label": "results", "text": "SUVave , SUVmax and SUVLV displayed similar relations with BG .", "sentence_id": 9}
+{"abstract_id": "24581596", "label": "results", "text": "SUVmax/SUVLV , but not SUVave/SUVLV , correlated significantly with BG .", "sentence_id": 10}
+{"abstract_id": "24581596", "label": "results", "text": "SUVmax , but not SUVave , correlated inversely with CT density before and after adjusting for BG .", "sentence_id": 11}
+{"abstract_id": "24581596", "label": "results", "text": "SUVmax/SUVave correlated more strongly with CT density than SUVmax .", "sentence_id": 12}
+{"abstract_id": "24581596", "label": "results", "text": "CT density correlated inversely with SUVmax/SUVLV but positively with SUVave/SUVLV .", "sentence_id": 13}
+{"abstract_id": "24581596", "label": "conclusions", "text": "Hepatic SUV is more influenced by BG than by HS .", "sentence_id": 14}
+{"abstract_id": "24581596", "label": "conclusions", "text": "Its relation with BG renders it unsuitable as a reference tissue .", "sentence_id": 15}
+{"abstract_id": "24581596", "label": "conclusions", "text": "Nevertheless , hepatic fat does correlate positively with liver SUV , although this is seen only with SUVmax because SUVave is ` diluted ' by hepatic fat .", "sentence_id": 16}
+{"abstract_id": "24703415", "label": "objective", "text": "To test whether a breakfast including eggs ( EB ) containing high-quality protein decreases subsequent food intake and increases satiety-related hormones in overweight or obese adults more than a breakfast including cereal ( CB ) of lower protein quality , but matched for energy density and macronutrient composition .", "sentence_id": 0}
+{"abstract_id": "24703415", "label": "methods", "text": "Twenty healthy overweight or obese subjects were randomized to eat an EB or a CB daily under supervision for one week , followed by a crossover to the opposite breakfast week after a two-week washout period .", "sentence_id": 1}
+{"abstract_id": "24703415", "label": "methods", "text": "On days @ and @ of each test week , a structured lunch was provided ad libitum .", "sentence_id": 2}
+{"abstract_id": "24703415", "label": "methods", "text": "Food intake , hunger and satiety scores , and blood parameters were measured before and after breakfast .", "sentence_id": 3}
+{"abstract_id": "24703415", "label": "methods", "text": "Outcomes were analyzed using mixed effects statistical models for repeated measures analysis of variance .", "sentence_id": 4}
+{"abstract_id": "24703415", "label": "results", "text": "Compared to the CB week , during the EB week , a ) feeling of fullness was greater ( P < @ ) on day @ but not on day @ ; b ) energy intake was not significantly lower on either day ; c ) right before lunch , acylated ghrelin was lower and PYY@-@ was higher on day @ ( P < @ and < @ , respectively ) but not on day @ ; d ) PYY@-@ , but not ghrelin , showed greater rise between breakfast and lunch on days @ ( P < @ ) and @ ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24703415", "label": "conclusions", "text": "Despite a highly similar energy density and macronutrient composition , the higher protein quality breakfast significantly influenced fullness , ghrelin and PYY@-@ .", "sentence_id": 6}
+{"abstract_id": "24703415", "label": "conclusions", "text": "Only the effect on PYY@-@ lasted throughout the week .", "sentence_id": 7}
+{"abstract_id": "24703415", "label": "conclusions", "text": "A next step would be to test if the benefits are pronounced and lasting , if protein quality of all meals is increased .", "sentence_id": 8}
+{"abstract_id": "24239210", "label": "background", "text": "Neoadjuvant chemotherapy with trastuzumab for patients with HER@-positive breast cancer can produce a pathological complete response in the breast in @-@ % of patients .", "sentence_id": 0}
+{"abstract_id": "24239210", "label": "background", "text": "We investigated the effect of the timing of trastuzumab administration with anthracycline and taxane neoadjuvant chemotherapy .", "sentence_id": 1}
+{"abstract_id": "24239210", "label": "methods", "text": "This randomised trial was done at @ centres in the USA and Puerto Rico .", "sentence_id": 2}
+{"abstract_id": "24239210", "label": "methods", "text": "Women with operable HER@-positive invasive breast cancer were randomly assigned ( @:@ ) with a biased coin minimisation algorithm , stratified for age , tumour size , and hormone receptor status .", "sentence_id": 3}
+{"abstract_id": "24239210", "label": "methods", "text": "Neither patients nor investigators ( except for a cardiac safety review panel ) were masked to treatment assignment .", "sentence_id": 4}
+{"abstract_id": "24239210", "label": "methods", "text": "Patients randomly assigned to sequential treatment received fluorouracil @ mg/m ( @ ) , epirubicin @ mg/m ( @ ) , and cyclophosphamide @ mg/m ( @ ) ( FEC-@ ) on day @ of a @-day cycle for four cycles followed by paclitaxel @ mg/m ( @ ) and trastuzumab @ mg/kg ( after a @ mg/kg loading dose ) once per week for @ weeks , while those randomly assigned to the concurrent treatment group received paclitaxel and trastuzumab once per week for @ weeks followed by four cycles of FEC-@ ( on day @ of each @-day cycle ) and once-weekly trastuzumab , in the same doses as the sequential group .", "sentence_id": 5}
+{"abstract_id": "24239210", "label": "methods", "text": "Surgery , including evaluation of the axilla , was done within @ weeks of completion of neoadjuvant treatment .", "sentence_id": 6}
+{"abstract_id": "24239210", "label": "methods", "text": "The primary outcome was the percentage of patients who had a pathological complete response in the intention-to-treat population .", "sentence_id": 7}
+{"abstract_id": "24239210", "label": "methods", "text": "The study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24239210", "label": "results", "text": "From Sept @ , @ , to Dec @ , @ , @ women were enrolled ( @ in the sequential group , @ in the concurrent group ) .", "sentence_id": 9}
+{"abstract_id": "24239210", "label": "results", "text": "Two patients in the sequential group withdrew consent before starting treatment .", "sentence_id": 10}
+{"abstract_id": "24239210", "label": "results", "text": "@ of @ ( @ % , @ % CI @-@ ) patients who received sequential treatment had a pathological complete response in the breast versus @ of @ ( @ % , @ % CI @-@ ) who received concurrent treatment ( difference @ % , @ % CI -@ to @ ) .", "sentence_id": 11}
+{"abstract_id": "24239210", "label": "results", "text": "No treatment-related deaths occurred .", "sentence_id": 12}
+{"abstract_id": "24239210", "label": "results", "text": "The most common severe toxic effects were neutropenia ( @ -LSB- @ % -RSB- of @ patients in the sequential group vs @ -LSB- @ % -RSB- of @ patients in the concurrent group ) and fatigue ( six -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) .", "sentence_id": 13}
+{"abstract_id": "24239210", "label": "results", "text": "Left ventricular ejection fraction dropped below the institutional lower limit of normal at week @ in one ( @ % ) of @ patients who received sequential treatment and four ( @ % ) of @ patients who received concurrent treatment ; by week @ , it had dropped below this limit in nine ( @ % ) of @ patients and in six ( @ % ) of @ patients , respectively .", "sentence_id": 14}
+{"abstract_id": "24239210", "label": "conclusions", "text": "Concurrent administration of trastuzumab with anthracyclines offers no additional benefit and is not warranted .", "sentence_id": 15}
+{"abstract_id": "24377213", "label": "objective", "text": "To compare the difference of the efficacy on knee osteoarthritis ( KOA ) between the combined therapy of acupuncture and moxibustion and western medication , and explore the better therapeutic method for KOA .", "sentence_id": 0}
+{"abstract_id": "24377213", "label": "methods", "text": "One hundred and sixty patients were divided into a combined therapy group and a western medication group , @ cases in each one according to the visit sequence , with the random number table adopted .", "sentence_id": 1}
+{"abstract_id": "24377213", "label": "methods", "text": "In the combined therapy group , the main points were selected from the local painful sites , combined with the acupoints based on the syndrome differentiation and distal acupoints on the affected meridians .", "sentence_id": 2}
+{"abstract_id": "24377213", "label": "methods", "text": "The lifting , thrusting or rotating technique was used and the reinforcing or reducing manipulation was applied according to the syndrome differentiation .", "sentence_id": 3}
+{"abstract_id": "24377213", "label": "methods", "text": "`` Duanci '' or `` Shuci '' needling technique was used specially at the extra points and Ashi points .", "sentence_id": 4}
+{"abstract_id": "24377213", "label": "methods", "text": "The needling sensation relied on the patients ' tolerance .", "sentence_id": 5}
+{"abstract_id": "24377213", "label": "methods", "text": "After acupuncture , the heat-sensitive moxibustion with pure moxa stick was applied over the local painful sites around knee joint and Shenshu ( BL @ ) to detect the heat-sensitized points .", "sentence_id": 6}
+{"abstract_id": "24377213", "label": "methods", "text": "Acupuncture and moxibustion were given once every day .", "sentence_id": 7}
+{"abstract_id": "24377213", "label": "methods", "text": "The treatment of @ days made @ session .", "sentence_id": 8}
+{"abstract_id": "24377213", "label": "methods", "text": "There were @ days at the interval between two sessions .", "sentence_id": 9}
+{"abstract_id": "24377213", "label": "methods", "text": "In the western medication group , glucosamine sulfate capsules were prescribed for oral administration , @ capsules each time , three times a day .", "sentence_id": 10}
+{"abstract_id": "24377213", "label": "methods", "text": "Additionally , the joint cavity injection was combined .", "sentence_id": 11}
+{"abstract_id": "24377213", "label": "methods", "text": "On the first day , sodium hyaluronate @ mg and triamcinolone acetonide acetate @ mg were injected .", "sentence_id": 12}
+{"abstract_id": "24377213", "label": "methods", "text": "Afterwards , on the @th , @th , @nd and @th days , sodium hyaluronate injection @ mg was used only .", "sentence_id": 13}
+{"abstract_id": "24377213", "label": "methods", "text": "The treatment was for @ weeks totally in the two groups .", "sentence_id": 14}
+{"abstract_id": "24377213", "label": "methods", "text": "The efficacy was analyzed statistically in @ weeks .", "sentence_id": 15}
+{"abstract_id": "24377213", "label": "methods", "text": "The follow-up visit was conducted in @ months and @ months after @ weeks treatment , respectively .", "sentence_id": 16}
+{"abstract_id": "24377213", "label": "methods", "text": "The Western Ontario and Mcmaster Universities Osteoarthritis Index ( WOMAC ) and visual analogue scale ( VAS ) were adopted to assess the recovery of joint function .", "sentence_id": 17}
+{"abstract_id": "24377213", "label": "results", "text": "The efficacy in @ weeks of treatment was different significantly between the two groups ( P < @ ) .", "sentence_id": 18}
+{"abstract_id": "24377213", "label": "results", "text": "The efficacy in the western medication group was better than that in the combined therapy group .", "sentence_id": 19}
+{"abstract_id": "24377213", "label": "results", "text": "The difference in the safety assessment was remarkable ( P < @ ) .", "sentence_id": 20}
+{"abstract_id": "24377213", "label": "results", "text": "The result in the combined therapy group was superior remarkably to the western medication group .", "sentence_id": 21}
+{"abstract_id": "24377213", "label": "results", "text": "In @-month follow-up visit after treatment , the knee joint function was not different obviously between the two groups ( P > @ ) .", "sentence_id": 22}
+{"abstract_id": "24377213", "label": "results", "text": "In @-month followup visit after treatment , the knee joint function was different obviously between the two groups ( P < @ ) .", "sentence_id": 23}
+{"abstract_id": "24377213", "label": "results", "text": "The result in the combined therapy group was better remarkably than that in the western medication group .", "sentence_id": 24}
+{"abstract_id": "24377213", "label": "conclusions", "text": "The combined therapy of acupuncture and moxibustion achieves the safe and effective therapeutic effect with less adverse reactions in the treatment of KOA .", "sentence_id": 25}
+{"abstract_id": "24377213", "label": "conclusions", "text": "The immediate effect in the combined therapy group is not so obvious as compared with the western medication , but the long-term efficacy is remarkably superior to western medication .", "sentence_id": 26}
+{"abstract_id": "25818495", "label": "background", "text": "The prognostic value of time from symptom onset to reperfusion may be enhanced by the identification of Q waves on the presenting electrocardiogram ( ECG ) in patients with ST-segment elevation myocardial infarction ( STEMI ) .", "sentence_id": 0}
+{"abstract_id": "25818495", "label": "background", "text": "We evaluated whether the relative prognostic utility of these @ metrics was altered by sex .", "sentence_id": 1}
+{"abstract_id": "25818495", "label": "methods", "text": "Q waves in the distribution of the ST-segment elevation on the baseline ECG were evaluated by a blinded core laboratory in @ STEMI patients ( @ men and @ women ) from the PLATelet inhibition and patient Outcomes ( PLATO ) trial who underwent percutaneous coronary intervention ( PCI ) within @ hours of symptom onset .", "sentence_id": 2}
+{"abstract_id": "25818495", "label": "results", "text": "Women were older ( median @ vs @ years ) , more likely to be diabetic ( @ % vs @ % ) , hypertensive ( @ % vs @ % ) , and a higher Killip class > I ( @ % vs @ % ) , as compared with men .", "sentence_id": 3}
+{"abstract_id": "25818495", "label": "results", "text": "Whereas the Q waves frequency rose progressively over time to ECG in men , this relationship was attenuated in women ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25818495", "label": "results", "text": "Q waves on the baseline ECG were associated with a higher excess hazard of @-year vascular death in men ( hazard ratio -LSB- HR -RSB- @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) , and a similar trend existed in women ( HR @ ; @ % CI , @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25818495", "label": "results", "text": "Women with baseline Q waves tended to have higher risk of @-year vascular death than men as continuous time from symptom onset to PCI increased ( P -LSB- interaction -RSB- = @ ) .", "sentence_id": 6}
+{"abstract_id": "25818495", "label": "conclusions", "text": "These differences in the evolution of baseline Q waves and relationship between time from symptom onset and vascular death in women and men deserve recognition in future studies of STEMI .", "sentence_id": 7}
+{"abstract_id": "25073486", "label": "background", "text": "In many countries a high proportion of births begin as induced labours .", "sentence_id": 0}
+{"abstract_id": "25073486", "label": "background", "text": "Induction can be lengthy if cervical priming is required prior to induction .", "sentence_id": 1}
+{"abstract_id": "25073486", "label": "background", "text": "This usually occurs as an inpatient , however , an alternative is to allow women to go home after satisfactory fetal monitoring .", "sentence_id": 2}
+{"abstract_id": "25073486", "label": "background", "text": "The aim of this study was to assess the preferences of women for cervical priming for induction of labour in an outpatient or inpatient setting .", "sentence_id": 3}
+{"abstract_id": "25073486", "label": "methods", "text": "A discrete choice experiment ( DCE ) was conducted alongside a randomised trial of inpatient and outpatient cervical priming ( the OPRA trial ) in two maternity hospitals in South Australia .", "sentence_id": 4}
+{"abstract_id": "25073486", "label": "methods", "text": "@ participants were included , and women 's preferences for cervical priming for induction of labour were assessed .", "sentence_id": 5}
+{"abstract_id": "25073486", "label": "results", "text": "Women were willing to accept an extra @ trips to hospital ( @ trips total ) and a total travel time of @ minutes to be able to return to their own home while waiting for the priming to work .", "sentence_id": 6}
+{"abstract_id": "25073486", "label": "results", "text": "For enhanced inpatient services , women were willing to accept a total travel time of @ minutes to have a private room with private bathroom while waiting for the priming to work .", "sentence_id": 7}
+{"abstract_id": "25073486", "label": "results", "text": "The overall benefit score for outpatient priming was @ , @ for enhanced inpatient care and @ for basic inpatient care , suggesting slightly greater preferences for outpatient priming .", "sentence_id": 8}
+{"abstract_id": "25073486", "label": "results", "text": "Preferences for outpatient priming increased when women could return to their own home ( compared to other offsite accommodation ) , and decreased with more trips to hospital and longer travel time .", "sentence_id": 9}
+{"abstract_id": "25073486", "label": "conclusions", "text": "Our results suggest that outpatient priming was slightly more preferred than either enhanced inpatient priming or basic care ; these results should be confirmed in different clinical settings .", "sentence_id": 10}
+{"abstract_id": "25073486", "label": "conclusions", "text": "There may be merit in providing women information about both options in the future , as preferences varied according to the characteristics of the services on offer and the sociodemographic background of the woman .", "sentence_id": 11}
+{"abstract_id": "25358450", "label": "objective", "text": "Tesamorelin is a synthetic analogue of growth hormone-releasing factor ( GRF ) , which increases basal and pulsatile growth hormone ( GH ) secretion and subsequently increases insulin-like growth factor ( IGF ) -@ .", "sentence_id": 0}
+{"abstract_id": "25358450", "label": "objective", "text": "Limited information is available about the pharmacokinetics of this compound .", "sentence_id": 1}
+{"abstract_id": "25358450", "label": "objective", "text": "Consequently , the aim of this study was to characterize the population pharmacokinetics of tesamorelin in HIV-infected patients and healthy subjects .", "sentence_id": 2}
+{"abstract_id": "25358450", "label": "methods", "text": "A total of @ HIV-infected patients and healthy subjects receiving subcutaneous tesamorelin doses of @ or @mg administered daily during @ consecutive days were included in the analysis .", "sentence_id": 3}
+{"abstract_id": "25358450", "label": "methods", "text": "An open one-compartment model with first - and zero-order absorption and first-order elimination was developed to best describe the data using NONMEM ( ) VII .", "sentence_id": 4}
+{"abstract_id": "25358450", "label": "methods", "text": "The effect of different covariates on tesamorelin pharmacokinetics was investigated .", "sentence_id": 5}
+{"abstract_id": "25358450", "label": "methods", "text": "Model evaluation was performed using predictive checks and non-parametric bootstrap .", "sentence_id": 6}
+{"abstract_id": "25358450", "label": "results", "text": "Plasma clearance and its interindividual variability -LSB- % coefficient of variation ( CV ) -RSB- was estimated to be @,@ L/h ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25358450", "label": "results", "text": "Volume of distribution was calculated to be @L ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "25358450", "label": "results", "text": "Age , body size measures , race and health status were not related to tesamorelin pharmacokinetic parameters within the range of covariates studied .", "sentence_id": 9}
+{"abstract_id": "25358450", "label": "results", "text": "The fraction of tesamorelin absorbed by a first-order process is @ % higher on day @ compared with day @ .", "sentence_id": 10}
+{"abstract_id": "25358450", "label": "results", "text": "Predictive checks and non-parametric bootstrap demonstrated that the model is appropriate in describing the time course of tesamorelin plasma concentrations in both HIV-infected patients and healthy subjects .", "sentence_id": 11}
+{"abstract_id": "25358450", "label": "conclusions", "text": "An open one-compartment model with first and zero order absorption processes and linear elimination is suitable to characterize the pharmacokinetics of tesamorelin .", "sentence_id": 12}
+{"abstract_id": "25358450", "label": "conclusions", "text": "The fraction of tesamorelin absorbed by a first-order process evolves with time .", "sentence_id": 13}
+{"abstract_id": "25358450", "label": "conclusions", "text": "No clinically relevant covariates were identified as predictors of tesamorelin pharmacokinetics .", "sentence_id": 14}
+{"abstract_id": "25975474", "label": "background", "text": "Neuron-specific enolase ( NSE ) is a widely-used biomarker for prognostication of neurological outcome after cardiac arrest , but the relevance of recommended cutoff values has been questioned due to the lack of a standardized methodology and uncertainties over the influence of temperature management .", "sentence_id": 0}
+{"abstract_id": "25975474", "label": "objective", "text": "This study investigated the role of NSE as a prognostic marker of outcome after out-of-hospital cardiac arrest ( OHCA ) in a contemporary setting .", "sentence_id": 1}
+{"abstract_id": "25975474", "label": "methods", "text": "A total of @ patients hospitalized after OHCA were randomized to targeted temperature management at either @C or @C .", "sentence_id": 2}
+{"abstract_id": "25975474", "label": "methods", "text": "NSE levels were assessed in blood samples obtained @ , @ , and @ h after return of spontaneous circulation .", "sentence_id": 3}
+{"abstract_id": "25975474", "label": "methods", "text": "The primary outcome was neurological outcome at @ months using the cerebral performance category score .", "sentence_id": 4}
+{"abstract_id": "25975474", "label": "results", "text": "NSE was a robust predictor of neurological outcome in a baseline variable-adjusted model , and target temperature did not significantly affect NSE values .", "sentence_id": 5}
+{"abstract_id": "25975474", "label": "results", "text": "Median NSE values were @ ng/ml versus @ ng/ml , @ ng/ml versus @ ng/ml , and @ ng/ml versus @ ng/ml for good versus poor outcome at @ , @ , and @ h , respectively ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25975474", "label": "results", "text": "At @ and @ h , NSE predicted neurological outcome with areas under the receiver-operating curve of @ and @ , respectively .", "sentence_id": 7}
+{"abstract_id": "25975474", "label": "results", "text": "High NSE cutoff values with false positive rates @ % and tight @ % confidence intervals were able to reliably predict outcome .", "sentence_id": 8}
+{"abstract_id": "25975474", "label": "conclusions", "text": "High , serial NSE values are strong predictors of poor outcome after OHCA .", "sentence_id": 9}
+{"abstract_id": "25975474", "label": "conclusions", "text": "Targeted temperature management at @C or @C does not significantly affect NSE levels .", "sentence_id": 10}
+{"abstract_id": "25975474", "label": "conclusions", "text": "( Target Temperature Management After Cardiac Arrest -LSB- TTM -RSB- ; NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24969395", "label": "background", "text": "Physical activity ( PA ) has documented health benefits , but older Latinos are less likely to engage in leisure time PA than older non-Latino whites .", "sentence_id": 0}
+{"abstract_id": "24969395", "label": "background", "text": "Dance holds a promise as a culturally appropriate form of PA that challenges individuals physically and cognitively .", "sentence_id": 1}
+{"abstract_id": "24969395", "label": "background", "text": "This paper describes a randomized controlled trial that will test the efficacy of BAILAMOS , a @-month Latin dance program followed by a @-month maintenance program , for improving lifestyle PA and health outcomes .", "sentence_id": 2}
+{"abstract_id": "24969395", "label": "methods", "text": "Older adults ( n = @ ) , aged @ + , Latino/Hispanic , Spanish speaking , with low PA levels , and at risk for disability will be randomized to one of two programs , a dance program or health education control group .", "sentence_id": 3}
+{"abstract_id": "24969395", "label": "methods", "text": "BAILAMOS is a @-month program that meets two times per week for one @h per session .", "sentence_id": 4}
+{"abstract_id": "24969395", "label": "methods", "text": "Dance sessions focus on instruction , including four styles of dance , and couples dancing .", "sentence_id": 5}
+{"abstract_id": "24969395", "label": "methods", "text": "Bi-monthly Fiestas de Baile ( dance parties ) are also included , in which participants dance and practice what they have learned .", "sentence_id": 6}
+{"abstract_id": "24969395", "label": "methods", "text": "Monthly @-hour discussion sessions utilize a Social Cognitive framework and focus on knowledge , social support , and self-efficacy to increase lifestyle PA. .", "sentence_id": 7}
+{"abstract_id": "24969395", "label": "methods", "text": "The health education control group will meet one time per week for two @h per session .", "sentence_id": 8}
+{"abstract_id": "24969395", "label": "results", "text": "Primary outcomes including PA changes and secondary outcomes including self-efficacy , physical function , cognitive function , and disability will be assessed at baseline , @ , and @ months .", "sentence_id": 9}
+{"abstract_id": "24969395", "label": "results", "text": "It is hypothesized that PA , self-efficacy , physical function , cognitive function , and functional limitations and disability scores will be significantly better in the BAILAMOS group at @ and @ months compared to the control group .", "sentence_id": 10}
+{"abstract_id": "25633911", "label": "background", "text": "The purpose of this study was to evaluate the influence of an early cardiac rehabilitation ( CR ) program on health-related quality of life ( HRQL ) and functional capacity in patients who recently experienced an acute myocardial infarction ( AMI ) .", "sentence_id": 0}
+{"abstract_id": "25633911", "label": "background", "text": "This program was initiated in the inpatient setting and was followed by an unsupervised outpatient intervention .", "sentence_id": 1}
+{"abstract_id": "25633911", "label": "methods", "text": "After the same inpatient care plan , low-risk patients who experienced an AMI were randomized into @ groups : ( @ ) a control group ( CG ) ( n = @ ) entailing usual care and ( @ ) an intervention group ( IG ) ( n = @ ) entailing outpatient ( unsupervised ) CR primarily centered on a progressive walking program .", "sentence_id": 2}
+{"abstract_id": "25633911", "label": "methods", "text": "Initially , all patients underwent a supervised exercise program with early mobilization beginning @hours after an AMI .", "sentence_id": 3}
+{"abstract_id": "25633911", "label": "methods", "text": "On hospital discharge , all patients were classified according to cardiovascular risk .", "sentence_id": 4}
+{"abstract_id": "25633911", "label": "methods", "text": "Quality of life was evaluated by the MacNew Heart Disease HRQL questionnaire @ days after discharge .", "sentence_id": 5}
+{"abstract_id": "25633911", "label": "methods", "text": "Functional capacity was determined by a @-minute walk test ( @MWT ) distance on the day of inpatient discharge as well as @ days afterward .", "sentence_id": 6}
+{"abstract_id": "25633911", "label": "results", "text": "The HRQL global score was higher in the IG compared with the CG @ days after discharge ( P < @ ) ; physical and emotional domain scores were both significantly higher in the IG ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25633911", "label": "results", "text": "Furthermore , the IG showed a greater @MWT distance compared with the CG ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25633911", "label": "conclusions", "text": "A CR program based on early progressive exercises , initiated by supervised inpatient training and followed by an unsupervised outpatient program , improved HRQL and functional capacity in patients at low cardiovascular risk who recently experienced an AMI .", "sentence_id": 9}
+{"abstract_id": "25024629", "label": "objective", "text": "To determine the dose-related effects of a novel probiotic combination , I. @ , on irritable bowel syndrome ( IBS ) - related quality of life ( IBS-QoL ) .", "sentence_id": 0}
+{"abstract_id": "25024629", "label": "methods", "text": "A multicenter , randomized , double-blind , placebo-controlled intervention clinical trial with three parallel arms was designed .", "sentence_id": 1}
+{"abstract_id": "25024629", "label": "methods", "text": "A total of @ patients ( @ female , @ male ; age range @-@ years ) with IBS and diarrhea according to Rome-III criteria were randomly allocated to receive one capsule a day for @ wk containing : ( @ ) I. @ high dose ( n = @ ) ; ( @ ) I. @ low dose ( n = @ ) ; and ( @ ) placebo ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25024629", "label": "methods", "text": "At baseline , and @ and @ wk of treatment , patients filled the IBSQoL , Visceral Sensitivity Index ( VSI ) , and global symptom relief questionnaires .", "sentence_id": 3}
+{"abstract_id": "25024629", "label": "results", "text": "During treatment , IBS-QoL increased in all groups , but this increment was significantly larger in patients treated with I. @ than in those receiving placebo ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25024629", "label": "results", "text": "After @ wk of treatment , IBS-QoL increased by @ @ and @ @ points in the high and the low dose groups , respectively ( P = @ and P = @ vs placebo ) , but only @ @ in the placebo group .", "sentence_id": 5}
+{"abstract_id": "25024629", "label": "results", "text": "Gut-specific anxiety , as measured with VSI , also showed a significantly greater improvement after @ wk of treatment in patients treated with probiotics ( by @ @ and @ @ points , high and low dose respectively , P < @ for both vs @ @ score increment in placebo ) .", "sentence_id": 6}
+{"abstract_id": "25024629", "label": "results", "text": "Symptom relief showed no significant changes between groups .", "sentence_id": 7}
+{"abstract_id": "25024629", "label": "results", "text": "No adverse drug reactions were reported following the consumption of probiotic or placebo capsules .", "sentence_id": 8}
+{"abstract_id": "25024629", "label": "conclusions", "text": "A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea .", "sentence_id": 9}
+{"abstract_id": "24299323", "label": "background", "text": "Pantoprazole magnesium ( pantoprazole-Mg ) may display extended inhibition of the proton pump with the potential for improved clinical efficacy in gastro-oesophageal reflux disease ( GERD ) .", "sentence_id": 0}
+{"abstract_id": "24299323", "label": "objective", "text": "To compare the efficacy of pantoprazole-Mg and esomeprazole in GERD .", "sentence_id": 1}
+{"abstract_id": "24299323", "label": "methods", "text": "Gastro-oesophageal reflux disease ( Los Angeles grades A-D ) patients were randomised to @weeks of treatment with pantoprazole-Mg ( n = @ ) or esomeprazole ( n = @ ) , both @mg once daily , in this multicentre ( @ Brazilian sites in @ cities ) , double-blind study , with an additional @weeks ' treatment in nonresponding patients .", "sentence_id": 2}
+{"abstract_id": "24299323", "label": "methods", "text": "Severity of oesophagitis ( at endoscopy ) and GERD-related symptoms ( ReQuest-GI ) were assessed .", "sentence_id": 3}
+{"abstract_id": "24299323", "label": "methods", "text": "The primary end point was the proportion of patients in complete remission ( ReQuest-GI score < @ plus endoscopic healing ) at week @ .", "sentence_id": 4}
+{"abstract_id": "24299323", "label": "results", "text": "Complete remission occurred in @ % of patients in each treatment group at @weeks ( primary endpoint ) and in @ % and @ % of patients in the pantoprazole-Mg and esomeprazole groups at @weeks , with no significant differences .", "sentence_id": 5}
+{"abstract_id": "24299323", "label": "results", "text": "Mucosal healing rates were high and not significantly different .", "sentence_id": 6}
+{"abstract_id": "24299323", "label": "results", "text": "At @weeks , symptom relief with pantoprazole-Mg was significantly greater than that with esomeprazole ( @ % vs. @ % , P = @ ) because of continued improvement in symptoms with pantoprazole-Mg from week @ to week @ ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24299323", "label": "conclusions", "text": "Pantoprazole-Mg @mg was at least as effective as esomeprazole @mg for complete remission and the mucosal healing rate was high .", "sentence_id": 8}
+{"abstract_id": "24299323", "label": "conclusions", "text": "Symptom relief with pantoprazole-Mg continued to improve from @ to @weeks and was greater than that with esomeprazole at week @ , suggesting an extended period of treatment effect ( ClinicalTrials.gov identifier : NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "25469520", "label": "background", "text": "Retaining HIV patients in medical care promotes access to antiretroviral therapy , viral load suppression , and reduced HIV transmission to partners .", "sentence_id": 0}
+{"abstract_id": "25469520", "label": "background", "text": "We estimate the programmatic costs of a US multisite randomized controlled trial of an intervention to retain HIV patients in care .", "sentence_id": 1}
+{"abstract_id": "25469520", "label": "methods", "text": "Six academically affiliated HIV clinics randomized patients to intervention ( enhanced personal contact with patients across time coupled with basic HIV education ) and control -LSB- standard of care ( SOC ) -RSB- arms .", "sentence_id": 2}
+{"abstract_id": "25469520", "label": "methods", "text": "Retention in care was defined as @-month visit constancy , that is , at least @ primary care visit in each @-month interval over a @-month period .", "sentence_id": 3}
+{"abstract_id": "25469520", "label": "methods", "text": "We used microcosting methods to collect unit costs and measure the quantity of resources used to implement the intervention in each clinic .", "sentence_id": 4}
+{"abstract_id": "25469520", "label": "methods", "text": "All fixed and variable labor and nonlabor costs of the intervention were included .", "sentence_id": 5}
+{"abstract_id": "25469520", "label": "results", "text": "Visit constancy was achieved by @ % ( @/@ ) of patients in the SOC arm and by @ % ( @/@ ) of patients in the intervention arm , representing an increase of @ patients ( relative improvement @ % ; @ % confidence interval : @ % to @ % ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25469520", "label": "results", "text": "The total annual cost of the intervention at the @ clinics was $ @,@ , the average cost per patient was $ @ , and the estimated cost per additional patient retained in care beyond SOC was $ @ .", "sentence_id": 7}
+{"abstract_id": "25469520", "label": "conclusions", "text": "Our analyses showed that a retention in care intervention consisting of enhanced personal contact coupled with basic HIV education may be delivered at fairly low cost .", "sentence_id": 8}
+{"abstract_id": "25469520", "label": "conclusions", "text": "These results provide useful information for guiding decisions about planning or scaling-up retention in care interventions for HIV-infected patients .", "sentence_id": 9}
+{"abstract_id": "24405796", "label": "objective", "text": "Although previous studies have demonstrated that a variety of local anesthetics are effective to decrease pain associated with tenaculum placement , no studies directly compare an injection with a topical anesthetic .", "sentence_id": 0}
+{"abstract_id": "24405796", "label": "objective", "text": "The objective of this study was therefore to compare mean pain scores with tenaculum placement after an intracervical lidocaine injection or topical lidocaine gel .", "sentence_id": 1}
+{"abstract_id": "24405796", "label": "methods", "text": "A randomized , single-blinded trial of women presenting for office gynecologic procedures that required a tenaculum .", "sentence_id": 2}
+{"abstract_id": "24405796", "label": "methods", "text": "Women aged @ years or older were randomized to receive either a @ % lidocaine intracervical injection or topical application of @ % lidocaine gel to the cervix immediately prior to tenaculum placement .", "sentence_id": 3}
+{"abstract_id": "24405796", "label": "methods", "text": "The primary outcome was pain at the time of tenaculum placement , measured on a @ mm Visual Analog Scale .", "sentence_id": 4}
+{"abstract_id": "24405796", "label": "methods", "text": "Secondary outcomes included pain with the intervention and satisfaction with tenaculum placement .", "sentence_id": 5}
+{"abstract_id": "24405796", "label": "results", "text": "Seventy-four women were enrolled and randomized ; @ subjects in each group met criteria for analysis .", "sentence_id": 6}
+{"abstract_id": "24405796", "label": "results", "text": "The two groups had similar socio-demographic characteristics .", "sentence_id": 7}
+{"abstract_id": "24405796", "label": "results", "text": "Women who received the injection had lower mean pain levels at tenaculum placement -LSB- @ mm ( S.D. @ mm ) versus @ mm ( S.D. @ mm ) , p < @ -RSB- but higher mean pain levels with study drug application -LSB- @ mm ( S.D. @ mm ) versus @ mm ( S.D. @ mm ) , p < @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "24405796", "label": "results", "text": "Satisfaction with tenaculum placement was similar for the two groups .", "sentence_id": 9}
+{"abstract_id": "24405796", "label": "conclusions", "text": "Mean pain with tenaculum placement is lower after receiving a lidocaine injection than after receiving a topical lidocaine gel .", "sentence_id": 10}
+{"abstract_id": "24405796", "label": "conclusions", "text": "Satisfaction with tenaculum placement is similar with both interventions .", "sentence_id": 11}
+{"abstract_id": "25270861", "label": "background", "text": "Over @ mastectomies are performed in England and Wales annually .", "sentence_id": 0}
+{"abstract_id": "25270861", "label": "background", "text": "Acute postoperative pain and nausea are common .", "sentence_id": 1}
+{"abstract_id": "25270861", "label": "background", "text": "The most frequently occurring long-term complications are chronic pain ( up to @ % ) and reduced shoulder function ( reported at @ % ) .", "sentence_id": 2}
+{"abstract_id": "25270861", "label": "background", "text": "Regional techniques that improve acute postoperative pain relief may reduce the incidence of these complications .", "sentence_id": 3}
+{"abstract_id": "25270861", "label": "background", "text": "This study assesses the effectiveness of a @-hour continuous local anaesthetic in the subpectoral plane in improving postoperative pain and quality of life in patients undergoing mastectomy .", "sentence_id": 4}
+{"abstract_id": "25270861", "label": "methods", "text": "This is a randomised , double blind , placebo-controlled , two-centre , parallel group trial in women undergoing mastectomy with or without axillary involvement .", "sentence_id": 5}
+{"abstract_id": "25270861", "label": "methods", "text": "One hundred and sixty participants will be randomised in a @:@ ratio to receive either @ % levobupivacaine or @ % saline by subpectoral infusion postoperatively for @h .", "sentence_id": 6}
+{"abstract_id": "25270861", "label": "methods", "text": "All participants will be provided with an intravenous morphine patient-controlled analgesia ( PCA ) system .", "sentence_id": 7}
+{"abstract_id": "25270861", "label": "methods", "text": "Participants will be followed-up for @h in hospital and at approximately @days and @months postoperatively .", "sentence_id": 8}
+{"abstract_id": "25270861", "label": "methods", "text": "Joint primary outcome measures are total morphine consumption and total pain score ( captured via patient-recorded visual analogue scale ( VAS ) @ hourly ) during the first @h postoperatively .", "sentence_id": 9}
+{"abstract_id": "25270861", "label": "methods", "text": "Primary statistical analysis of total pain is based on the area under the curve of pain versus time graph .", "sentence_id": 10}
+{"abstract_id": "25270861", "label": "methods", "text": "Secondary outcomes include PCA attempts in first @h ; VAS pain scores and shoulder function by goniometry at @h , @days ( approximately ) and @months ; Verbal Rating Scale pain scores in first @h ; Brief Pain Inventory and Oxford Shoulder Score at @months ; duration of hospital stay ; incidence of postoperative nausea and vomiting ; cost-effectiveness .", "sentence_id": 11}
+{"abstract_id": "25270861", "label": "background", "text": "The study is approved by the South West England Research Ethics Committee ( @/SW/@ ) .", "sentence_id": 12}
+{"abstract_id": "25270861", "label": "results", "text": "will be published in a peer-reviewed journal and presented at local , national and international scientific meetings .", "sentence_id": 13}
+{"abstract_id": "25118091", "label": "background", "text": "Case conferences for people with dementia and challenging behaviors ( e.g. , apathy ) are recommended as useful tools that enable staff in nursing homes to understand the behavior of people with this type of disease .", "sentence_id": 0}
+{"abstract_id": "25118091", "label": "background", "text": "Understanding peoples ' behaviors is the basis for the initiation of targeted interventions to improve the quality of care for people with dementia .", "sentence_id": 1}
+{"abstract_id": "25118091", "label": "background", "text": "Furthermore , case conferences demonstrate positive effects on burnout , dementia-specific burden , and vocational action competence of the staff .", "sentence_id": 2}
+{"abstract_id": "25118091", "label": "background", "text": "The two likely approaches for conducting case conferences include the following : A ) using a structured assessment instrument , which guides the staff in understanding the residents ' behaviors and B ) using a narrative approach in which the staff must identify the reasons for the residents ' behaviors in an unstructured manner .", "sentence_id": 3}
+{"abstract_id": "25118091", "label": "background", "text": "Case conferences are a complex intervention , and evaluating their multiple effects is challenging .", "sentence_id": 4}
+{"abstract_id": "25118091", "label": "background", "text": "The aim of this study protocol was to describe a likely solution for evaluating this type of complex intervention using a special cluster randomized trial .", "sentence_id": 5}
+{"abstract_id": "25118091", "label": "methods", "text": "In this stepped-wedged cluster randomized trial , the two interventions will be sequentially implemented every three months in a group of @ nursing homes ( clusters ) with a minimum of @ residents over @months ( @months of intervention for each cluster and follow-up ) .", "sentence_id": 6}
+{"abstract_id": "25118091", "label": "methods", "text": "The primary outcome is the reduction of challenging behavior ( measured with the neuropsychiatric inventory-nursing home version -LSB- NPI-NH -RSB- ) .", "sentence_id": 7}
+{"abstract_id": "25118091", "label": "methods", "text": "Secondary outcomes are residents ' quality of life , prescription of psychotropic medications , staff burnout , dementia-related stress , and vocational action competence .", "sentence_id": 8}
+{"abstract_id": "25118091", "label": "methods", "text": "The effectiveness of the study will be accompanied by a process evaluation .", "sentence_id": 9}
+{"abstract_id": "25118091", "label": "methods", "text": "The primary data will be analyzed using a Bayesian mixed effect model ; the secondary data will be analyzed using descriptive statistics and mixed effects models .", "sentence_id": 10}
+{"abstract_id": "25118091", "label": "conclusions", "text": "The implementation and effect measurement of complex interventions such as case conferences within a cluster randomized trial are challenging ( e.g. , complex and intensive training , delayed treatment effect ) .", "sentence_id": 11}
+{"abstract_id": "25118091", "label": "conclusions", "text": "In this study protocol , the methodological advantages and disadvantages of using the stepped wedge design to answer the research questions are discussed .", "sentence_id": 12}
+{"abstract_id": "24592984", "label": "background", "text": "Owing to their potential to act as estrogen receptor modulators and interfere with aromatase enzyme in animal studies , phytoestrogens ( PE ) may be useful as part of ovulation induction for polycystic ovary syndrome ( PCOS ) .", "sentence_id": 0}
+{"abstract_id": "24592984", "label": "methods", "text": "Patients < @ years , presenting with infertility and PCOS , were included and randomly allocated to either group I ( clomiphene citrate ; CC ) or group II ( CC plus Cimicifugae racemosae ; CR ) .", "sentence_id": 1}
+{"abstract_id": "24592984", "label": "methods", "text": "Primary outcome was pregnancy rate .", "sentence_id": 2}
+{"abstract_id": "24592984", "label": "methods", "text": "Secondary outcomes included ovulation , midcycle serum estradiol and luteinizing hormone ( LH ) as well as mid-luteal serum progesterone .", "sentence_id": 3}
+{"abstract_id": "24592984", "label": "results", "text": "Analysis included @ patients in group I versus @ patients in group II .", "sentence_id": 4}
+{"abstract_id": "24592984", "label": "results", "text": "Both groups were matched regarding demographics and basic data .", "sentence_id": 5}
+{"abstract_id": "24592984", "label": "results", "text": "Significant differences were elicited when comparing days until HCG injection ( @ @ versus @ @ , p = @ ) , endometrial thickness ( mm ) ( @ @ versus @ @ , p < @ ) , serum levels of mid-luteal and midcycle estradiol ( p < @ ; Figure @ ) , LH ( IU/ml ) ( p < @ ) as well as mid-luteal progesterone ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24592984", "label": "results", "text": "PE plus CC group had significantly higher clinical pregnancies per cycle ( @/@ ( @ % ) versus @/@ ( @ % ) , p < @ ) , compared to the CC only group .", "sentence_id": 7}
+{"abstract_id": "24592984", "label": "conclusions", "text": "Adding CR to clomiphene-induction cycles with timed intercourse in polycystic ovarian syndrome improves cycle outcomes and pregnancy rates .", "sentence_id": 8}
+{"abstract_id": "25461822", "label": "objective", "text": "To compare response to upper-limb treatment using robotics plus motor learning ( ML ) versus functional electrical stimulation ( FES ) plus ML versus ML alone , according to a measure of complex functional everyday tasks for chronic , severely impaired stroke survivors .", "sentence_id": 0}
+{"abstract_id": "25461822", "label": "methods", "text": "Single-blind , randomized trial .", "sentence_id": 1}
+{"abstract_id": "25461822", "label": "methods", "text": "Medical center .", "sentence_id": 2}
+{"abstract_id": "25461822", "label": "methods", "text": "Enrolled subjects ( N = @ ) were > @ year postsingle stroke ( attrition rate = @ % ; @ completed the study ) .", "sentence_id": 3}
+{"abstract_id": "25461822", "label": "methods", "text": "All groups received treatment @d/wk for @h/d ( @ sessions ) , with unique treatment as follows : ML alone ( n = @ ) ( @h/d partial - and whole-task practice of complex functional tasks ) , robotics plus ML ( n = @ ) ( @ h/d of ML and @ h/d of shoulder/elbow robotics ) , and FES plus ML ( n = @ ) ( @ h/d of ML and @ h/d of FES wrist/hand coordination training ) .", "sentence_id": 4}
+{"abstract_id": "25461822", "label": "methods", "text": "Primary measure : Arm Motor Ability Test ( AMAT ) , with @ complex functional tasks ; secondary measure : upper-limb Fugl-Meyer coordination scale ( FM ) .", "sentence_id": 5}
+{"abstract_id": "25461822", "label": "results", "text": "There was no significant difference found in treatment response across groups ( AMAT : P. @ ; FM coordination : P. @ ) .", "sentence_id": 6}
+{"abstract_id": "25461822", "label": "results", "text": "All @ treatment groups demonstrated clinically and statistically significant improvement in response to treatment ( AMAT and FM coordination : P. @ ) .", "sentence_id": 7}
+{"abstract_id": "25461822", "label": "results", "text": "A group treatment paradigm of @:@ ( therapist/patient ) ratio proved feasible for provision of the intensive treatment .", "sentence_id": 8}
+{"abstract_id": "25461822", "label": "results", "text": "No adverse effects .", "sentence_id": 9}
+{"abstract_id": "25461822", "label": "conclusions", "text": "Severely impaired stroke survivors with persistent ( > @y ) upper-extremity dysfunction can make clinically and statistically significant gains in coordination and functional task performance in response to robotics plus ML , FES plus ML , and ML alone in an intensive and long-duration intervention ; no group differences were found .", "sentence_id": 10}
+{"abstract_id": "25461822", "label": "conclusions", "text": "Additional studies are warranted to determine the effectiveness of these methods in the clinical setting .", "sentence_id": 11}
+{"abstract_id": "24686107", "label": "background", "text": "The IMMEDIATE ( Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care ) Trial , a randomized controlled double-blind clinical effectiveness trial of glucose-insulin-potassium ( GIK ) administered in ambulances in the out-of-hospital setting , used the Exception from Informed Consent Requirements ( EFIC ) for Emergency Research under Title @ of the Code of Federal Regulations .", "sentence_id": 0}
+{"abstract_id": "24686107", "label": "background", "text": "EFIC requirements include community consultation that typically involves using a variety of communication methods and venues to inform the public of the research and to receive their feedback .", "sentence_id": 1}
+{"abstract_id": "24686107", "label": "background", "text": "Although not the primary purpose of the community consultation process , a common concern to research sponsors , staff , and institutional review boards ( IRBs ) is whether there will be a sufficient number of participants to justify mounting a study in their community .", "sentence_id": 2}
+{"abstract_id": "24686107", "label": "background", "text": "Information from community consultation regarding the community acceptance might inform this question .", "sentence_id": 3}
+{"abstract_id": "24686107", "label": "objective", "text": "We evaluated the utility of telephone survey data done as part of the EFIC process as a way to project the ultimate rate of trial participant enrollment .", "sentence_id": 4}
+{"abstract_id": "24686107", "label": "methods", "text": "A telephone survey community consultation process was undertaken in nine communities planning to be IMMEDIATE Trial sites using a representative sampling of the target population in the areas covered by participating emergency medical service ( EMS ) agencies .", "sentence_id": 5}
+{"abstract_id": "24686107", "label": "methods", "text": "Survey respondents were read a description of the planned study and its informed consent approach that included the option for patients to decline participation in the trial while being transported for acute care in an ambulance .", "sentence_id": 6}
+{"abstract_id": "24686107", "label": "methods", "text": "Survey respondents were then asked whether they would object to participating in the study .", "sentence_id": 7}
+{"abstract_id": "24686107", "label": "methods", "text": "At the conclusion of actual trial enrollment , the Coordinating Center compared the survey results with the actual rates of enrollment at each site .", "sentence_id": 8}
+{"abstract_id": "24686107", "label": "results", "text": "Approximately @ ( range = @-@ ) respondents completed the survey in each of the study communities .", "sentence_id": 9}
+{"abstract_id": "24686107", "label": "results", "text": "Of @ survey respondents , @ % ( range = @ % -@ % ) said that they would not object to participating in the trial if experiencing a heart attack , and @ % ( range = @ % -@ % ) said that they would allow the study to be done in their community .", "sentence_id": 10}
+{"abstract_id": "24686107", "label": "results", "text": "During actual trial enrollment in the communities , @ % ( range = @ % -@ % ) of the @ potential participants agreed in the ambulance to have the study drug started and provided informed consent at the hospital , an average of @ percentage-points higher than projected by the survey ( @ % confidence interval ( CI ) : @ % -@ % ) , @ % higher on a relative scale ( CI : @ % -@ % ) .", "sentence_id": 11}
+{"abstract_id": "24686107", "label": "conclusions", "text": "The survey-based approach to community consultation proved to be an efficient way to obtain representative input from potential clinical trial participants .", "sentence_id": 12}
+{"abstract_id": "24686107", "label": "conclusions", "text": "The survey data generated a relatively good and conservative estimate of the ultimate rate of trial enrollment .", "sentence_id": 13}
+{"abstract_id": "24686107", "label": "conclusions", "text": "This information could be useful to investigators and IRBs in projecting enrollment for clinical trials using EFIC .", "sentence_id": 14}
+{"abstract_id": "24946625", "label": "objective", "text": "To verify the clinical efficacy of acupuncture on motor dysfunction in ischemic stroke of subacute stage .", "sentence_id": 0}
+{"abstract_id": "24946625", "label": "methods", "text": "The multi-central randomized controlled trial was adopted .", "sentence_id": 1}
+{"abstract_id": "24946625", "label": "methods", "text": "One hundred and twenty-six cases of ischemic stroke of subacute stage were randomized into an acupuncture group ( @ cases ) and a conventional treatment group ( @ cases ) .", "sentence_id": 2}
+{"abstract_id": "24946625", "label": "methods", "text": "The basic treatment of western internal medicine and rehabilitation training were applied to the patients of the two groups .", "sentence_id": 3}
+{"abstract_id": "24946625", "label": "methods", "text": "In the acupuncture group , acupuncture was supplemented at the body points located on the extensor of the upper limbs and the flexor of the lower limbs .", "sentence_id": 4}
+{"abstract_id": "24946625", "label": "methods", "text": "In combination , scalp acupuncture was applied to NS@ , MS@ and MS@ on the affected side .", "sentence_id": 5}
+{"abstract_id": "24946625", "label": "methods", "text": "The treatment was given @ times a week and totally @ weeks were required .", "sentence_id": 6}
+{"abstract_id": "24946625", "label": "methods", "text": "The follow-up observation lasted for @ months .", "sentence_id": 7}
+{"abstract_id": "24946625", "label": "methods", "text": "The scores in Fugl-Meyer scale and NIHSS scale and Barthel index were compared between the two groups before treatment , in @ and @ weeks of treatment and the @-month follow-up observation after treatment separately .", "sentence_id": 8}
+{"abstract_id": "24946625", "label": "results", "text": "In @ and @ weeks of treatment and the follow-up observation , Fugl-Meyer scale score was improved obviously in the patients of the two groups ( all P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24946625", "label": "results", "text": "In @ weeks of treatment and the follow-up observation , Fugl-Meyer scale score in the acupuncture groupwas im proved much apparently as compared with that in the conventional treatment group -LSB- @ ( @,@ ) vs @ ( @ , @ ) , @ ( @ , @ ) vs @ ( @ , @ ) , both P < @ -RSB- .", "sentence_id": 10}
+{"abstract_id": "24946625", "label": "results", "text": "Except that NIHSS scale score was not reduced apparently in @ weeks of treatment in the conventional treatment group ( P > @ ) , the results of NIHSS scale at the other time points were all decreased obviously as compared with those before treatment in the patients of the two groups ( all P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24946625", "label": "results", "text": "In @ weeks of treatment and the follow-up observation , the results in the acupuncture group were reduced much apparently as compared with those in the conventional treatment group -LSB- @ ( @,@ ) vs @ ( @,@ ) , @ ( @,@ ) vs @ ( @,@ ) , both P < @ -RSB- .", "sentence_id": 12}
+{"abstract_id": "24946625", "label": "results", "text": "In @ weeks of treatment and the follow-up observation , Barthel index was improved obviously as compared with that before treatment in the patients of the two groups ( all P < @ ) .", "sentence_id": 13}
+{"abstract_id": "24946625", "label": "results", "text": "The improvement in the acupuncture group was much more significant as compared with the conventional treatment group -LSB- @ ( @,@ ) vs @ .", "sentence_id": 14}
+{"abstract_id": "24946625", "label": "results", "text": "O ( @ , @ ) , P < @ .", "sentence_id": 15}
+{"abstract_id": "24946625", "label": "conclusions", "text": "Based on the conventional treatment , Acupuncture achieves the satisfactory clinical efficacy on motor dysfunction in ischemic stroke of subacute stage .", "sentence_id": 16}
+{"abstract_id": "25454414", "label": "background", "text": "Fluorouracil and irinotecan-based , and gemcitabine-based regimens , are the standard of care in the first-line treatment of patients with metastatic pancreatic cancer .", "sentence_id": 0}
+{"abstract_id": "25454414", "label": "background", "text": "New approaches are needed to improve survival and quality of life .", "sentence_id": 1}
+{"abstract_id": "25454414", "label": "background", "text": "Whether a sequential approach alternating irinotecan , fluorouracil and gemcitabine may be effective and tolerable in patients with metastatic pancreatic cancer is unknown .", "sentence_id": 2}
+{"abstract_id": "25454414", "label": "methods", "text": "In this randomised , multicentre , open-label , phase @ trial , patients with metastatic pancreatic adenocarcinoma , World Health Organisation ( WHO ) performance status @-@ , and bilirubin levels < @ upper limit of normal values ( ULN ) were randomised @:@ to receive as first-line treatment either FOLFIRI @ ( irinotecan , leucovorin and fluorouracil ) alternating with fixed-dose rate gemcitabine as @-month periods ( FIRGEM , arm A ) , or fixed-dose rate gemcitabine alone ( arm B ) .", "sentence_id": 3}
+{"abstract_id": "25454414", "label": "methods", "text": "Treatment was continued until disease progression or limiting toxicity .", "sentence_id": 4}
+{"abstract_id": "25454414", "label": "methods", "text": "The primary end-point was the crude progression-free survival ( PFS ) rate at @ months .", "sentence_id": 5}
+{"abstract_id": "25454414", "label": "methods", "text": "The study is registered with EudraCT ( N @-@-@ ) .", "sentence_id": 6}
+{"abstract_id": "25454414", "label": "results", "text": "Between October @ and March @ , @ patients were enroled .", "sentence_id": 7}
+{"abstract_id": "25454414", "label": "results", "text": "The observed @-month PFS rate was @ % ( @ % confidence interval ( CI ) , -LSB- @-@ @ % -RSB- ) in arm A reaching the Fleming decision rules criteria to reject H@ and @ % ( @ % CI -LSB- @-@ @ % -RSB- ) in arm B. Objective response rates were @ % ( @-@ % ) in arm A and @ % ( @-@ % ) in arm B. Median PFS ( @ versus @ months , hazard ratio ( HR ) = @ -LSB- @-@ @ -RSB- ) and overall survival ( @ versus @ months , HR = @ -LSB- @-@ @ -RSB- ) were higher in arm A compared to arm B.", "sentence_id": 8}
+{"abstract_id": "25454414", "label": "results", "text": "The most frequent grade @-@ toxicities were neutropenia ( @ % / @ % ; febrile neutropenia , @ % / @ % in arms A/B ) , diarrhoea ( arm A , @ % and arm B , @ % ) , and nausea/vomiting ( @ % / @ % ) .", "sentence_id": 9}
+{"abstract_id": "25454414", "label": "results", "text": "No toxic deaths occurred .", "sentence_id": 10}
+{"abstract_id": "25454414", "label": "conclusions", "text": "The FIRGEM strategy appears to be effective and feasible in patients with metastatic pancreatic cancer .", "sentence_id": 11}
+{"abstract_id": "25121977", "label": "background", "text": "Antidepressant prescriptions have increased exponentially , burdening health care costs .", "sentence_id": 0}
+{"abstract_id": "25121977", "label": "objective", "text": "To evaluate the costs and effects of an antidepressant cessation advice in case of inappropriate long-term use in primary care , i.e. long-term usage without a ( current ) indication .", "sentence_id": 1}
+{"abstract_id": "25121977", "label": "methods", "text": "A economic evaluation during @-year follow-up was performed , from a societal perspective , as part of a cluster-randomised controlled clinical trial ( PANDA ) .", "sentence_id": 2}
+{"abstract_id": "25121977", "label": "methods", "text": "Costs were assessed using the Trimbos/iMTA questionnaire for costs associated with psychiatric illness .", "sentence_id": 3}
+{"abstract_id": "25121977", "label": "methods", "text": "Health-related quality of life was measured using the EuroQol @D .", "sentence_id": 4}
+{"abstract_id": "25121977", "label": "methods", "text": "Outcome was costs per quality adjusted life year ( QALY ) .", "sentence_id": 5}
+{"abstract_id": "25121977", "label": "methods", "text": "Missing values were estimated using multiple imputation , bootstrap simulations were performed to address the uncertainty surrounding the incremental cost-effectiveness ratios ( ICERs ) .", "sentence_id": 6}
+{"abstract_id": "25121977", "label": "results", "text": "There was no difference in average QALYs between the intervention ( @ ) and control group ( @ ) -LSB- difference -@ ( @ % CI -@ to @ ) -RSB- .", "sentence_id": 7}
+{"abstract_id": "25121977", "label": "results", "text": "The intervention group , however , was less expensive than the control group ( total costs @ versus @ , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25121977", "label": "results", "text": "Most cost-effectiveness pairs were located in the south-west quadrant of the cost-effectiveness plane , implying the intervention was less effective but also less costly .", "sentence_id": 9}
+{"abstract_id": "25121977", "label": "results", "text": "The ICER of the pooled data was @,@ , meaning that for one QALY lost , @,@ is saved .", "sentence_id": 10}
+{"abstract_id": "25121977", "label": "conclusions", "text": "This study shows that an antidepressant cessation advice given to patients ( and their FPs ) with inappropriate long-term antidepressant usage , albeit not effective , does seem to result in a reduction of societal costs .", "sentence_id": 11}
+{"abstract_id": "25121977", "label": "conclusions", "text": "This reduction in costs is mostly due to reduction of productivity losses , possibly due to patient empowerment and loss of stigma .", "sentence_id": 12}
+{"abstract_id": "25066329", "label": "background", "text": "Evidence is weak for the ability of long-term non-invasive positive pressure ventilation ( NPPV ) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease ( COPD ) .", "sentence_id": 0}
+{"abstract_id": "25066329", "label": "background", "text": "Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings .", "sentence_id": 1}
+{"abstract_id": "25066329", "label": "background", "text": "This study investigated the effect of long-term NPPV , targeted to markedly reduce hypercapnia , on survival in patients with advanced , stable hypercapnic COPD .", "sentence_id": 2}
+{"abstract_id": "25066329", "label": "methods", "text": "This investigator-initiated , prospective , multicentre , randomised , controlled clinical trial enrolled patients with stable GOLD stage IV COPD and a partial carbon dioxide pressure ( PaCO@ ) of @ kPa ( @ mm Hg ) or higher and pH higher than @ .", "sentence_id": 3}
+{"abstract_id": "25066329", "label": "methods", "text": "NPPV was targeted to reduce baseline PaCO@ by at least @ % or to achieve PaCO@ values lower than @ kPa ( @ mm Hg ) .", "sentence_id": 4}
+{"abstract_id": "25066329", "label": "methods", "text": "Patients were randomly assigned ( in a @:@ ratio ) via a computer-generated randomisation sequence with a block size of four , to continue optimised standard treatment ( control group ) or to receive additional NPPV for at least @ months ( intervention group ) .", "sentence_id": 5}
+{"abstract_id": "25066329", "label": "methods", "text": "The primary outcome was @-year all-cause mortality .", "sentence_id": 6}
+{"abstract_id": "25066329", "label": "methods", "text": "Analysis was by intention to treat .", "sentence_id": 7}
+{"abstract_id": "25066329", "label": "methods", "text": "The intervention was unblinded , but outcome assessment was blinded to treatment assignment .", "sentence_id": 8}
+{"abstract_id": "25066329", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25066329", "label": "results", "text": "Patients were recruited from @ respiratory units in Germany and Austria , starting on Oct @ , @ , and terminated with a record of the vital status on July @ , @ patients were randomly assigned to the NPPV group ( n = @ ) or to the control group ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "25066329", "label": "results", "text": "All patients from the control group and the NPPV group were included in the primary analysis .", "sentence_id": 11}
+{"abstract_id": "25066329", "label": "results", "text": "@-year mortality was @ % ( @ of @ patients ) in the intervention group and @ % ( @ of @ patients ) in the control group ; hazard ratio @ ( @ % CI @-@ @ ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25066329", "label": "results", "text": "@ ( @ % ) patients reported facial skin rash , which could be managed by changing the type of the mask .", "sentence_id": 13}
+{"abstract_id": "25066329", "label": "results", "text": "No other intervention-related adverse events were reported .", "sentence_id": 14}
+{"abstract_id": "25066329", "label": "conclusions", "text": "The addition of long-term NPPV to standard treatment improves survival of patients with hypercapnic , stable COPD when NPPV is targeted to greatly reduce hypercapnia .", "sentence_id": 15}
+{"abstract_id": "24643203", "label": "background", "text": "Previous phase III studies in patients with advanced Parkinson 's disease ( PD ) not adequately controlled on levodopa demonstrated significant reduction of ` off ' time with rotigotine transdermal system up to @ mg/@ h. However , the minimal effective dose has not been established .", "sentence_id": 0}
+{"abstract_id": "24643203", "label": "objective", "text": "This international , randomized , double-blind , placebo-controlled study ( SP@ ; NCT@ ) investigated rotigotine dose response up to @ mg/@ h.", "sentence_id": 1}
+{"abstract_id": "24643203", "label": "methods", "text": "Patients with advanced idiopathic PD ( @ h of daily ` off ' time on stable doses of levodopa ) were randomized @:@:@:@:@ to receive rotigotine @ , @ , @ , or @ mg/@ h or placebo , titrated over @ weeks and maintained for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24643203", "label": "methods", "text": "The primary efficacy variable was change from baseline to end of maintenance in absolute time spent ` off ' .", "sentence_id": 3}
+{"abstract_id": "24643203", "label": "results", "text": "@/@ ( @ % ) randomized patients completed maintenance .", "sentence_id": 4}
+{"abstract_id": "24643203", "label": "results", "text": "Mean ( SD ) baseline daily ` off ' times ( h/day ) were placebo : @ ( @ ) , rotigotine @-@ mg/@ h : @ ( @ ) .", "sentence_id": 5}
+{"abstract_id": "24643203", "label": "results", "text": "Rotigotine @ mg/@ h was the minimal dose to significantly reduce ` off ' time versus placebo .", "sentence_id": 6}
+{"abstract_id": "24643203", "label": "results", "text": "LS mean ( SE ) absolute change in daily ` off ' time ( h/day ) from baseline was -@ ( @ ) with rotigotine @ mg/@ h , and -@ ( @ ) with placebo ; absolute change in ` off ' time in the @ mg/@ h group compared with placebo was -@ h/day ( @ % CI -@ , -@ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24643203", "label": "results", "text": "There was an apparent dose-dependent trend .", "sentence_id": 8}
+{"abstract_id": "24643203", "label": "results", "text": "Adverse events ( AEs ) reported at a higher incidence in the rotigotine @ mg/@ h group versus placebo included application site reactions , nausea , dry mouth , and dyskinesia ; there was no worsening of insomnia , somnolence , orthostatic hypotension , confusional state or hallucinations , even in patients @ years of age .", "sentence_id": 9}
+{"abstract_id": "24643203", "label": "conclusions", "text": "The minimal statistically significant effective dose of rotigotine to reduce absolute ` off ' time was @ mg/@ h.", "sentence_id": 10}
+{"abstract_id": "24643203", "label": "conclusions", "text": "The AE profile was similar to previous studies .", "sentence_id": 11}
+{"abstract_id": "24622715", "label": "background", "text": "Metformin reduces cardiovascular risk in patients with type @ diabetes seemingly independent of lowering blood glucose concentration .", "sentence_id": 0}
+{"abstract_id": "24622715", "label": "background", "text": "We assessed the cardiovascular effects of metformin in individuals without type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "24622715", "label": "methods", "text": "We did a single-centre , double-blind , placebo-controlled trial at the Glasgow Clinical Research Facility ( Glasgow , UK ) .", "sentence_id": 2}
+{"abstract_id": "24622715", "label": "methods", "text": "We enrolled patients taking statins who did not have type @ diabetes but who did have coronary heart disease and large waist circumferences .", "sentence_id": 3}
+{"abstract_id": "24622715", "label": "methods", "text": "Participants were randomly assigned ( @:@ ) by computer to either metformin ( @ mg twice daily ) or matching placebo in block sizes of four .", "sentence_id": 4}
+{"abstract_id": "24622715", "label": "methods", "text": "Patients , investigators , trial staff , and statisticians were masked to treatment allocation .", "sentence_id": 5}
+{"abstract_id": "24622715", "label": "methods", "text": "The primary endpoint was progression of mean distal carotid intima-media thickness ( cIMT ) over @ months in the modified intention-to-treat population .", "sentence_id": 6}
+{"abstract_id": "24622715", "label": "methods", "text": "Secondary endpoints were changes in carotid plaque score ( in six regions ) , measures of glycaemia ( HbA@c , fasting glucose , and insulin concentrations , and Homeostasis Model Assessment of Insulin Resistance -LSB- HOMA-IR -RSB- ) , and concentrations of lipids , high sensitivity C-reactive protein , and tissue plasminogen activator .", "sentence_id": 7}
+{"abstract_id": "24622715", "label": "methods", "text": "The trial was registered at ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24622715", "label": "results", "text": "We screened @ patients , of whom we enrolled @ ( @ in the metformin group , @ in the placebo group ) .", "sentence_id": 9}
+{"abstract_id": "24622715", "label": "results", "text": "Average age was @ years .", "sentence_id": 10}
+{"abstract_id": "24622715", "label": "results", "text": "At baseline , mean cIMT was @ mm ( SD @ ) and mean carotid plaque score was @ ( SD @ ) .", "sentence_id": 11}
+{"abstract_id": "24622715", "label": "results", "text": "cIMT progression did not differ significantly between groups ( slope difference @ mm per year , @ % CI -@ to @ ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24622715", "label": "results", "text": "Change of carotid plaque score did not differ significantly between groups ( @ per year , @ % CI -@ to @ ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24622715", "label": "results", "text": "Patients taking metformin had lower HbA@c , insulin , HOMA-IR , and tissue plasminogen activator compared with those taking placebo , but there were no significant differences for total cholesterol , HDL-cholesterol , non-HDL-cholesterol , triglycerides , high sensitivity C-reactive protein , or fasting glucose .", "sentence_id": 14}
+{"abstract_id": "24622715", "label": "results", "text": "@ adverse events occurred in @ patients in the metformin group versus @ in @ patients in the placebo group .", "sentence_id": 15}
+{"abstract_id": "24622715", "label": "results", "text": "Diarrhoea and nausea or vomiting were more common in the metformin group than in the placebo group ( @ vs @ ) .", "sentence_id": 16}
+{"abstract_id": "24622715", "label": "conclusions", "text": "Metformin had no effect on cIMT and little or no effect on several surrogate markers of cardiovascular disease in non-diabetic patients with high cardiovascular risk , taking statins .", "sentence_id": 17}
+{"abstract_id": "24622715", "label": "conclusions", "text": "Further evidence is needed before metformin can be recommended for cardiovascular benefit in this population .", "sentence_id": 18}
+{"abstract_id": "25662415", "label": "background", "text": "Most patients with hip fractures are characterised by older age ( > @ years ) , frailty , and functional deterioration , and their long-term outcomes are poor with increased costs .", "sentence_id": 0}
+{"abstract_id": "25662415", "label": "background", "text": "We compared the effectiveness and cost-effectiveness of giving these patients comprehensive geriatric care in a dedicated geriatric ward versus the usual orthopaedic care .", "sentence_id": 1}
+{"abstract_id": "25662415", "label": "methods", "text": "We did a prospective , single-centre , randomised , parallel-group , controlled trial .", "sentence_id": 2}
+{"abstract_id": "25662415", "label": "methods", "text": "Between April @ , @ , and Dec @ , @ , we randomly assigned home-dwelling patients with hip-fractures aged @ years or older who were able to walk @ m before their fracture , to either comprehensive geriatric care or orthopaedic care in the emergency department , to achieve the required sample of @ patients .", "sentence_id": 3}
+{"abstract_id": "25662415", "label": "methods", "text": "Randomisation was achieved via a web-based , computer-generated , block method with unknown block sizes .", "sentence_id": 4}
+{"abstract_id": "25662415", "label": "methods", "text": "The primary outcome , analysed by intention to treat , was mobility measured with the Short Physical Performance Battery ( SPPB ) @ months after surgery for the fracture .", "sentence_id": 5}
+{"abstract_id": "25662415", "label": "methods", "text": "The type of treatment was not concealed from the patients or staff delivering the care , and assessors were only partly masked to the treatment during follow-up .", "sentence_id": 6}
+{"abstract_id": "25662415", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "25662415", "label": "results", "text": "We assessed @ patients for eligibility , and excluded @ , mainly for not meeting the inclusion criteria such as living in a nursing home or being aged less than @ years .", "sentence_id": 8}
+{"abstract_id": "25662415", "label": "results", "text": "Of the remaining patients , we randomly assigned @ to comprehensive geriatric care and @ to orthopaedic care .", "sentence_id": 9}
+{"abstract_id": "25662415", "label": "results", "text": "At @ months , @ patients remained in the comprehensive geriatric care group and @ in the orthopaedic care group ; the main reason for dropout was death .", "sentence_id": 10}
+{"abstract_id": "25662415", "label": "results", "text": "Mean SPPB scores at @ months were @ ( SE @ ) for comprehensive geriatric care and @ ( SE @ ) for orthopaedic care ( between-group difference @ , @ % CI @-@ , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25662415", "label": "conclusions", "text": "Immediate admission of patients aged @ years or more with a hip fracture to comprehensive geriatric care in a dedicated ward improved mobility at @ months , compared with the usual orthopaedic care .", "sentence_id": 12}
+{"abstract_id": "25662415", "label": "conclusions", "text": "The results suggest that the treatment of older patients with hip fractures should be organised as orthogeriatric care .", "sentence_id": 13}
+{"abstract_id": "24586327", "label": "background", "text": "Community level interventions to improve maternal and child health have been supported and well evaluated in resource poor settings , but less so in developed countries .", "sentence_id": 0}
+{"abstract_id": "24586327", "label": "background", "text": "PRISM -- Program of Resources , Information and Support for Mothers -- was a primary care and community-based cluster-randomised trial in sixteen municipalities in Victoria , Australia , which aimed to reduce depression in mothers and improve their physical health .", "sentence_id": 1}
+{"abstract_id": "24586327", "label": "background", "text": "The aim of this paper is to report the longer term outcomes of PRISM and to reflect on lessons learned from this universal community intervention to improve maternal health .", "sentence_id": 2}
+{"abstract_id": "24586327", "label": "methods", "text": "Maternal health outcome data in PRISM were collected by postal questionnaire at six months and two years .", "sentence_id": 3}
+{"abstract_id": "24586327", "label": "methods", "text": "At two years , the main outcome measures included the Edinburgh Postnatal Depression Scale ( EPDS ) and the SF-@ .", "sentence_id": 4}
+{"abstract_id": "24586327", "label": "methods", "text": "Secondary outcome measures included the Experience of Motherhood Scale ( EOM ) and the Parenting Stress Index ( PSI ) .", "sentence_id": 5}
+{"abstract_id": "24586327", "label": "methods", "text": "A primary intention to treat analysis was conducted , adjusting for the randomisation by cluster .", "sentence_id": 6}
+{"abstract_id": "24586327", "label": "results", "text": "@,@ / @,@ ( @ % ) women responded to the postal questionnaire at two years -@,@ ( @ % ) in the intervention arm and @,@ ( @ % ) in the comparison arm .", "sentence_id": 7}
+{"abstract_id": "24586327", "label": "results", "text": "Respondents were mostly representative on available population data comparisons .", "sentence_id": 8}
+{"abstract_id": "24586327", "label": "results", "text": "There were no differences in depression prevalence ( EPDS@ ) between the intervention and comparison arms ( @ % vs @ % ; ORadj = @ , @ % CI @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "24586327", "label": "results", "text": "Nor did women 's mental health ( MCS : @ vs @ ) or physical health scores ( PCS : @ vs @ ) on the SF-@ differ between the trial arms .", "sentence_id": 10}
+{"abstract_id": "24586327", "label": "conclusions", "text": "Improvement in maternal mental and physical health outcomes at the population level in the early years after childbirth remains a largely unmet challenge .", "sentence_id": 11}
+{"abstract_id": "24586327", "label": "conclusions", "text": "Despite the lack of effectiveness of PRISM intervention strategies , important lessons about systems change , sustained investment and contextual understanding of the workability of intervention strategies can be drawn from the experience of PRISM .", "sentence_id": 12}
+{"abstract_id": "24586327", "label": "conclusions", "text": "Trial Registration .", "sentence_id": 13}
+{"abstract_id": "24586327", "label": "conclusions", "text": "Controlled-Trials .", "sentence_id": 14}
+{"abstract_id": "24586327", "label": "conclusions", "text": "com ISRCTN@ .", "sentence_id": 15}
+{"abstract_id": "24479722", "label": "objective", "text": "To compare the safety and efficacy of a single subconjunctival injection of methylprednisolone and a standard postoperative steroid regimen in terms of intraocular inflammation and intraocular pressure ( IOP ) after uncomplicated phacoemulsification surgery .", "sentence_id": 0}
+{"abstract_id": "24479722", "label": "methods", "text": "Two groups of @ patients each were included in this prospective randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24479722", "label": "methods", "text": "Patients in the injection group were given a subconjunctival injection of @ mg methylprednisolone and the topical group received the conventional postoperative care with steroid eye drops ( dexamethasone @ mg/ml ) .", "sentence_id": 2}
+{"abstract_id": "24479722", "label": "methods", "text": "The patients were examined @ week and @ month after surgery .", "sentence_id": 3}
+{"abstract_id": "24479722", "label": "methods", "text": "Slit-lamp evaluation of anterior chamber inflammation and IOP were performed .", "sentence_id": 4}
+{"abstract_id": "24479722", "label": "methods", "text": "Changes in IOP of @ mmHg were considered clinically relevant .", "sentence_id": 5}
+{"abstract_id": "24479722", "label": "results", "text": "In the injection group , mean IOP decreased from @ @ mmHg ( baseline ) to @ @ mmHg at @ week ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24479722", "label": "results", "text": "The topical group had a stable IOP at @ week ( @ @ mmHg ) compared to baseline ( @ @ mmHg ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24479722", "label": "results", "text": "At @ month , mean IOP was @ @ mmHg ( p = @ ) in the injection group and @ @ mmHg ( p = @ ) in the topical group .", "sentence_id": 8}
+{"abstract_id": "24479722", "label": "results", "text": "The intragroup changes were neither statistically significant nor clinically relevant at any postoperative visit .", "sentence_id": 9}
+{"abstract_id": "24479722", "label": "results", "text": "Both groups had the highest values of intraocular inflammation at the @-week postoperative visit , followed by a decline to barely traceable levels at @ month .", "sentence_id": 10}
+{"abstract_id": "24479722", "label": "results", "text": "The difference was not clinically relevant at any postoperative visit .", "sentence_id": 11}
+{"abstract_id": "24479722", "label": "conclusions", "text": "The subconjunctival injection of methylprednisolone appears to be as safe and effective as the conventional treatment , and it might therefore be considered for treatment of individuals with compliance issues .", "sentence_id": 12}
+{"abstract_id": "24933136", "label": "objective", "text": "To examine the feasibility , acceptability , and potential effectiveness of an online intervention targeting college smokers .", "sentence_id": 0}
+{"abstract_id": "24933136", "label": "objective", "text": "The incentives involved discounted or free goods and services from businesses proximal to each campus .", "sentence_id": 1}
+{"abstract_id": "24933136", "label": "methods", "text": "A randomized controlled trial was conducted with @ current smokers recruited from @ Southeastern US universities .", "sentence_id": 2}
+{"abstract_id": "24933136", "label": "methods", "text": "The intervention involved health behavior monitoring , targeted messaging , and incentives for healthy goods and services versus the American Cancer Society 's Guide to Quitting Smoking online .", "sentence_id": 3}
+{"abstract_id": "24933136", "label": "results", "text": "The intervention achieved greater adherence and utilization ( p 's < @ ) .", "sentence_id": 4}
+{"abstract_id": "24933136", "label": "results", "text": "Overall , @ % learned about a local business through this program .", "sentence_id": 5}
+{"abstract_id": "24933136", "label": "results", "text": "At end-of-treatment , intervention participants less frequently attempted to quit ( p = @ ) but smoked fewer cigarettes/day ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24933136", "label": "results", "text": "Both groups demonstrated significant end-of-treatment cessation rates .", "sentence_id": 7}
+{"abstract_id": "24933136", "label": "conclusions", "text": "This intervention demonstrated feasibility and acceptability .", "sentence_id": 8}
+{"abstract_id": "25056602", "label": "background", "text": "The optimal model of total dose and fraction size for patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy ( IMRT ) remains unclear .", "sentence_id": 0}
+{"abstract_id": "25056602", "label": "background", "text": "The authors designed a randomized phase @ clinical trial to investigate the efficacy of @ different models , with the objective of determining an optimal model .", "sentence_id": 1}
+{"abstract_id": "25056602", "label": "methods", "text": "Between January @ and December @ , a total of @ patients with locally recurrent nonmetastatic nasopharyngeal carcinoma were randomized to @ different models of total dose and fraction size : group A ( @ patients ) received @ gray in @ fractions and group B ( @ patients ) received @ gray in @ fractions .", "sentence_id": 2}
+{"abstract_id": "25056602", "label": "methods", "text": "Both groups received @ daily fractions per week .", "sentence_id": 3}
+{"abstract_id": "25056602", "label": "methods", "text": "All patients received IMRT alone .", "sentence_id": 4}
+{"abstract_id": "25056602", "label": "results", "text": "The median follow-up was @ months .", "sentence_id": 5}
+{"abstract_id": "25056602", "label": "results", "text": "The @-year overall survival in group A was higher than that in group B ( @ % vs @ % ; P = @ ) , and the local failure-free survival in group A was slightly lower than that in group B ( @ % vs @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25056602", "label": "results", "text": "Severe late complications were the main cause of death .", "sentence_id": 7}
+{"abstract_id": "25056602", "label": "results", "text": "The incidences of mucosal necrosis and massive hemorrhage in patients in group B were significantly higher than those among patients in group A at @ % versus @ % ( P = @ ) and @ % versus @ % ( P = @ ) , respectively .", "sentence_id": 8}
+{"abstract_id": "25056602", "label": "results", "text": "Tumor volume ( P < @ ) and model of total dose and fraction size ( P = @ ) were found to be significant factors for mucosal necrosis and massive hemorrhage .", "sentence_id": 9}
+{"abstract_id": "25056602", "label": "conclusions", "text": "Appropriately decreasing the total dose and increasing the fraction size can achieve local control similar to that achieved with a higher dose after IMRT ; furthermore , it can improve overall survival by significantly reducing the incidence of severe late complications including mucosal necrosis and massive hemorrhage .", "sentence_id": 10}
+{"abstract_id": "25197733", "label": "objective", "text": "To examine the effect of chocobar ice cream containing bifidobacteria on salivary mutans streptococci and lactobacilli .", "sentence_id": 0}
+{"abstract_id": "25197733", "label": "methods", "text": "A double-blind , randomised controlled trial was conducted with @ subjects ( @ to @ years of age ) divided into @ groups , test ( chocobar ice cream with probiotics ) and control ( chocobar ice cream without probiotics ) .", "sentence_id": 1}
+{"abstract_id": "25197733", "label": "methods", "text": "The subjects were instructed to eat the allotted chocobar ice cream once daily for @ days .", "sentence_id": 2}
+{"abstract_id": "25197733", "label": "methods", "text": "Saliva samples collected at intervals were cultured on Mitis Salivarius agar and Rogosa agar and examined for salivary mutans streptococci and lactobacilli , respectively .", "sentence_id": 3}
+{"abstract_id": "25197733", "label": "methods", "text": "The Mann-Whitney U-test , Friedman and Wilcoxon signed-rank tests were used for statistical analysis .", "sentence_id": 4}
+{"abstract_id": "25197733", "label": "results", "text": "Postingestion in the test group , a statistically significant reduction ( p < @ ) of salivary mutans streptococci was recorded , but a non-significant trend was seen for lactobacilli .", "sentence_id": 5}
+{"abstract_id": "25197733", "label": "results", "text": "Significant differences were was also observed between follow-ups .", "sentence_id": 6}
+{"abstract_id": "25197733", "label": "conclusions", "text": "Short-term daily ingestion of ice cream containing probiotic bifidobacteria may reduce salivary levels of mutans streptococci in young adults .", "sentence_id": 7}
+{"abstract_id": "26398071", "label": "background", "text": "The standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate .", "sentence_id": 0}
+{"abstract_id": "26398071", "label": "background", "text": "Ovarian stimulation with letrozole has been proposed to reduce multiple gestations while maintaining live birth rates .", "sentence_id": 1}
+{"abstract_id": "26398071", "label": "methods", "text": "We enrolled couples with unexplained infertility in a multicenter , randomized trial .", "sentence_id": 2}
+{"abstract_id": "26398071", "label": "methods", "text": "Ovulatory women @ to @ years of age with at least one patent fallopian tube were randomly assigned to ovarian stimulation ( up to four cycles ) with gonadotropin ( @ women ) , clomiphene ( @ ) , or letrozole ( @ ) .", "sentence_id": 3}
+{"abstract_id": "26398071", "label": "methods", "text": "The primary outcome was the rate of multiple gestations among women with clinical pregnancies .", "sentence_id": 4}
+{"abstract_id": "26398071", "label": "results", "text": "After treatment with gonadotropin , clomiphene , or letrozole , clinical pregnancies occurred in @ % , @ % , and @ % of cycles , and live birth in @ % , @ % , and @ % , respectively ; pregnancy rates with letrozole were significantly lower than the rates with standard therapy ( gonadotropin or clomiphene ) ( P = @ ) or gonadotropin alone ( P < @ ) but not with clomiphene alone ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "26398071", "label": "results", "text": "Among ongoing pregnancies with fetal heart activity , the multiple gestation rate with letrozole ( @ of @ pregnancies , @ % ) did not differ significantly from the rate with gonadotropin or clomiphene ( @ of @ , @ % ; P = @ ) or clomiphene alone ( @ of @ , @ % ; P = @ ) but was lower than the rate with gonadotropin alone ( @ of @ , @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26398071", "label": "results", "text": "All multiple gestations in the clomiphene and letrozole groups were twins , whereas gonadotropin treatment resulted in @ twin and @ triplet gestations .", "sentence_id": 7}
+{"abstract_id": "26398071", "label": "results", "text": "There were no significant differences among groups in the frequencies of congenital anomalies or major fetal and neonatal complications .", "sentence_id": 8}
+{"abstract_id": "26398071", "label": "conclusions", "text": "In women with unexplained infertility , ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation but also a lower frequency of live birth , as compared with gonadotropin but not as compared with clomiphene .", "sentence_id": 9}
+{"abstract_id": "26398071", "label": "conclusions", "text": "( Funded by the National Institutes of Health and others ; ClinicalTrials.gov number , NCT@ . )", "sentence_id": 10}
+{"abstract_id": "25018069", "label": "objective", "text": "To assess the optimal pancreatic phase delay in terms of parenchymal enhancement and tumor-to-pancreas contrast with a bolus-tracking method .", "sentence_id": 0}
+{"abstract_id": "25018069", "label": "methods", "text": "Patients referred for suspicion of pancreatic tumor and undergoing @-detector computed tomography scanner were randomized to an individualized scan delay of @ , @ , or @seconds of nonionic contrast material ( @mg I/mL ) after aortic enhancement above @ Hounsfield units .", "sentence_id": 1}
+{"abstract_id": "25018069", "label": "methods", "text": "The volume of contrast was adjusted to patient weight .", "sentence_id": 2}
+{"abstract_id": "25018069", "label": "methods", "text": "Pancreatic and tumor enhancements were measured .", "sentence_id": 3}
+{"abstract_id": "25018069", "label": "methods", "text": "Statistical analysis included analysis of variance and post hoc Tukey tests .", "sentence_id": 4}
+{"abstract_id": "25018069", "label": "results", "text": "One hundred and fifty patients were randomized to individualized scan delays of @ , @ , or @seconds .", "sentence_id": 5}
+{"abstract_id": "25018069", "label": "results", "text": "Pancreatic parenchymal enhancement in all patients ( n = @ ) was significantly higher with a delay of @ or @ seconds than that with @ seconds ( P < @ for both ) .", "sentence_id": 6}
+{"abstract_id": "25018069", "label": "results", "text": "Tumor-to-pancreas contrast for solid tumors ( n = @ ) was significantly higher with a delay of @seconds than that with @seconds ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25018069", "label": "results", "text": "Adenocarcinoma-to-pancreas contrast during pancreatic phase was significantly higher for a @ - or @-second delay than for a @-second delay ( P = @ and @ , respectively ) for one reader .", "sentence_id": 8}
+{"abstract_id": "25018069", "label": "conclusions", "text": "With a flow rate of @mL/s and weight-adjusted contrast volume , an individualized scan delay of @seconds after aortic transit time revealed higher pancreatic enhancement and tumor-to-pancreas contrast than that with a delay of @seconds .", "sentence_id": 9}
+{"abstract_id": "25282565", "label": "background", "text": "Epidemiologic and preclinical data , and a small randomized trial in Boston , suggest that vitamin D supplementation may improve winter-related atopic dermatitis ( AD ) .", "sentence_id": 0}
+{"abstract_id": "25282565", "label": "objective", "text": "To determine the effect of vitamin D supplementation on winter-related AD .", "sentence_id": 1}
+{"abstract_id": "25282565", "label": "methods", "text": "We performed a randomized , double-blind , placebo-controlled trial of Mongolian children with winter-related AD ( clinicaltrials.gov identifier : NCT@ ) .", "sentence_id": 2}
+{"abstract_id": "25282565", "label": "methods", "text": "Baseline eligibility included age @ to @ years , AD score @ to @ using the Eczema Area and Severity Index ( EASI ) , and winter-related AD ( eg , history of AD worsening during the fall-to-winter transition ) .", "sentence_id": 3}
+{"abstract_id": "25282565", "label": "methods", "text": "Subjects were enrolled in Ulaanbaatar during winter and randomly assigned to oral cholecalciferol ( @ IU/day ) versus placebo for @ month .", "sentence_id": 4}
+{"abstract_id": "25282565", "label": "methods", "text": "All children and parents received emollient and patient education about AD and basic skin care .", "sentence_id": 5}
+{"abstract_id": "25282565", "label": "methods", "text": "The main outcomes were changes in EASI score and in Investigator 's Global Assessment .", "sentence_id": 6}
+{"abstract_id": "25282565", "label": "results", "text": "The @ enrolled children had a mean age of @ years ( SD @ ) , and @ % were male .", "sentence_id": 7}
+{"abstract_id": "25282565", "label": "results", "text": "Their median age of AD onset was @ months ( interquartile range @ months to @ year ) and mean EASI score at baseline @ ( SD @ ) .", "sentence_id": 8}
+{"abstract_id": "25282565", "label": "results", "text": "One-month follow-up data were available for @ ( @ % ) children .", "sentence_id": 9}
+{"abstract_id": "25282565", "label": "results", "text": "Compared with placebo , vitamin D supplementation for @ month produced a clinically and statistically significant improvement in EASI score ( adjusted mean change : -@ vs -@ , respectively ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25282565", "label": "results", "text": "Moreover , change in Investigator 's Global Assessment favored vitamin D over placebo ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25282565", "label": "results", "text": "There were no adverse effects in either group .", "sentence_id": 12}
+{"abstract_id": "25282565", "label": "conclusions", "text": "Vitamin D supplementation improved winter-related AD among Mongolian children , a population likely to have vitamin D deficiency in winter .", "sentence_id": 13}
+{"abstract_id": "24753478", "label": "methods", "text": "Since bolus administration of capsaicin has been shown to reduce appetite and ad libitum energy intake , this study elucidated the satiating effect of the less pungent capsaicin analog , nonivamide , on subjective feelings of hunger , ad libitum food intake , and satiating hormones in moderately overweight male subjects .", "sentence_id": 0}
+{"abstract_id": "24753478", "label": "results", "text": "Following a randomized , crossover design , @ male subjects ( BMI @ @ kg/m ( @ ) ) received either @ g glucose in @ mL water ( control treatment , CT ) or the same glucose solution supplemented with @ mg nonivamide ( nonivamide treatment , NT ) .", "sentence_id": 1}
+{"abstract_id": "24753478", "label": "results", "text": "Ratings of hunger were assessed before and @ h after each intervention by means of visual analog scales .", "sentence_id": 2}
+{"abstract_id": "24753478", "label": "results", "text": "Ad libitum energy and macronutrient intakes from a standardized breakfast @ h postintervention were calculated .", "sentence_id": 3}
+{"abstract_id": "24753478", "label": "results", "text": "Plasma glucose , insulin , peptide YY ( @-@ ) , glucagon-like peptide @ , and serotonin were quantified in blood samples drawn before and @ , @ , @ , @ , and @ min after each intervention .", "sentence_id": 4}
+{"abstract_id": "24753478", "label": "results", "text": "NT reduced subjective feelings of hunger and ad libitum energy and carbohydrate intakes from a standardized breakfast compared to CT. .", "sentence_id": 5}
+{"abstract_id": "24753478", "label": "results", "text": "Plasma analysis revealed higher mean plasma glucagon-like peptide @ and serotonin concentrations after NT versus CT. .", "sentence_id": 6}
+{"abstract_id": "24753478", "label": "conclusions", "text": "Addition of @ mg nonivamide to a glucose solution reduced ad libitum energy intake from a standardized breakfast in moderately overweight men .", "sentence_id": 7}
+{"abstract_id": "25271544", "label": "objective", "text": "Selective decontamination of the digestive tract ( SDD ) and selective oropharyngeal decontamination ( SOD ) are prophylactic antibiotic regimens used in intensive care units ( ICUs ) and associated with improved patient outcome .", "sentence_id": 0}
+{"abstract_id": "25271544", "label": "objective", "text": "Controversy exists regarding the relative effects of both measures on patient outcome and antibiotic resistance .", "sentence_id": 1}
+{"abstract_id": "25271544", "label": "objective", "text": "To compare the effects of SDD and SOD , applied as unit-wide interventions , on antibiotic resistance and patient outcome .", "sentence_id": 2}
+{"abstract_id": "25271544", "label": "methods", "text": "Pragmatic , cluster randomized crossover trial comparing @ months of SOD with @ months of SDD in @ Dutch ICUs between August @ , @ , and February @ , @ .", "sentence_id": 3}
+{"abstract_id": "25271544", "label": "methods", "text": "Patients with an expected length of ICU stay longer than @ hours were eligible to receive the regimens , and @ and @ patients were included in the clinical outcome analysis for SOD and SDD , respectively .", "sentence_id": 4}
+{"abstract_id": "25271544", "label": "methods", "text": "Intensive care units were randomized to administer either SDD or SOD .", "sentence_id": 5}
+{"abstract_id": "25271544", "label": "methods", "text": "Unit-wide prevalence of antibiotic-resistant gram-negative bacteria .", "sentence_id": 6}
+{"abstract_id": "25271544", "label": "methods", "text": "Secondary outcomes were day-@ mortality , ICU-acquired bacteremia , and length of ICU stay .", "sentence_id": 7}
+{"abstract_id": "25271544", "label": "results", "text": "In point-prevalence surveys , prevalences of antibiotic-resistant gram-negative bacteria in perianal swabs were significantly lower during SDD compared with SOD ; for aminoglycoside resistance , average prevalence was @ % ( @ % CI , @ % -@ % ) during SDD and @ % ( @ % CI , @ % -@ % ) during SOD ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25271544", "label": "results", "text": "During both interventions the prevalence of rectal carriage of aminoglycoside-resistant gram-negative bacteria increased @ % per month ( @ % CI , @ % -@ % ) during SDD ( P = @ ) and @ % per month ( @ % CI , @ % -@ % ) during SOD ( P = @ ; P = @ for difference ) .", "sentence_id": 9}
+{"abstract_id": "25271544", "label": "results", "text": "Day @-mortality was @ % and @ % during SOD and SDD , respectively ( adjusted odds ratio , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ) , and there were no statistically significant differences in other outcome parameters or between surgical and nonsurgical patients .", "sentence_id": 10}
+{"abstract_id": "25271544", "label": "results", "text": "Intensive care unit-acquired bacteremia occurred in @ % and @ % of the patients during SOD and SDD , respectively ( odds ratio , @ -LSB- @ % CI , @-@ @ -RSB- ; P = @ ; number needed to treat , @ ) .", "sentence_id": 11}
+{"abstract_id": "25271544", "label": "conclusions", "text": "Unit-wide application of SDD and SOD was associated with low levels of antibiotic resistance and no differences in day-@ mortality .", "sentence_id": 12}
+{"abstract_id": "25271544", "label": "conclusions", "text": "Compared with SOD , SDD was associated with lower rectal carriage of antibiotic-resistant gram-negative bacteria and ICU-acquired bacteremia but a more pronounced gradual increase in aminoglycoside-resistant gram-negative bacteria .", "sentence_id": 13}
+{"abstract_id": "24888209", "label": "objective", "text": "This study explored possible mechanisms through which symptoms of posttraumatic stress disorder ( PTSD ) were reduced in a randomized controlled trial comparing the effect of a yoga intervention with an assessment control .", "sentence_id": 0}
+{"abstract_id": "24888209", "label": "methods", "text": "We examined whether changes in psychological flexibility , mindfulness , and emotion regulation strategies ( expressive suppression and reappraisal ) were associated with posttreatment PTSD symptoms for @ women with Diagnostic and Statistical Manual of Mental Disorders Fourth Edition full or subthreshold PTSD .", "sentence_id": 1}
+{"abstract_id": "24888209", "label": "results", "text": "Hierarchical linear regression models revealed that expressive suppression significantly decreased for the yoga group relative to the assessment control .", "sentence_id": 2}
+{"abstract_id": "24888209", "label": "results", "text": "Psychological flexibility increased significantly for the control but not yoga group .", "sentence_id": 3}
+{"abstract_id": "24888209", "label": "results", "text": "However , increases in psychological flexibility were associated with decreases in PTSD symptoms for the yoga but not control group .", "sentence_id": 4}
+{"abstract_id": "24888209", "label": "conclusions", "text": "Preliminary findings suggest that yoga may reduce expressive suppression and may improve PTSD symptoms by increasing psychological flexibility .", "sentence_id": 5}
+{"abstract_id": "24888209", "label": "conclusions", "text": "More research is needed to replicate and extend these findings .", "sentence_id": 6}
+{"abstract_id": "24748630", "label": "objective", "text": "Assess golimumab 's long-term efficacy/safety in psoriatic arthritis ( PsA ) .", "sentence_id": 0}
+{"abstract_id": "24748630", "label": "methods", "text": "Adults with active PsA ( @ swollen and tender joints , active psoriasis ) were randomly assigned to subcutaneous placebo , golimumab @mg , or golimumab @mg every @weeks ( q@wks ) through wk@ .", "sentence_id": 1}
+{"abstract_id": "24748630", "label": "methods", "text": "All patients received golimumab @mg or @mg q@wks from wk@ forward .", "sentence_id": 2}
+{"abstract_id": "24748630", "label": "methods", "text": "Methotrexate was allowed and taken by approximately half the patients .", "sentence_id": 3}
+{"abstract_id": "24748630", "label": "methods", "text": "Findings through @years are reported herein .", "sentence_id": 4}
+{"abstract_id": "24748630", "label": "methods", "text": "Efficacy assessments included @ % improvement in American College of Rheumatology ( ACR@ ) response , C-reactive-protein-based , @-joint-count Disease Activity Score ( DAS@-CRP ) response , @ % improvement in Psoriasis Area and Severity Index ( PASI@ ) scores , and PsA-modified Sharp/van der Heijde scores ( SHSs ) .", "sentence_id": 5}
+{"abstract_id": "24748630", "label": "results", "text": "@/@ ( @ % ) randomised patients discontinued treatment through wk@ .", "sentence_id": 6}
+{"abstract_id": "24748630", "label": "results", "text": "Golimumab was effective in maintaining clinical improvement through year-@ ( ACR@ : @-@ @ % , DAS@-CRP : @-@ @ % for randomised patients ; PASI@ : @-@ @ % among randomised patients with @ % body surface area involvement ) and inhibiting radiographic progression ( mean changes in PsA-modified SHS : @-@ @ ) among patients with radiographic data .", "sentence_id": 7}
+{"abstract_id": "24748630", "label": "results", "text": "While concomitant methotrexate did not affect ACR@/PASI@ , it appeared to reduce radiographic progression .", "sentence_id": 8}
+{"abstract_id": "24748630", "label": "results", "text": "No new safety signals were identified .", "sentence_id": 9}
+{"abstract_id": "24748630", "label": "results", "text": "Antibodies-to-golimumab occurred in @ % / @ % of patients with/without methotrexate ) .", "sentence_id": 10}
+{"abstract_id": "24748630", "label": "conclusions", "text": "Long-term golimumab safety/efficacy in PsA was demonstrated through @years .", "sentence_id": 11}
+{"abstract_id": "26006702", "label": "objective", "text": "Onapristone is an antiprogestin with activity in breast cancer and is under investigation for use in endometrial , ovarian and prostate cancers .", "sentence_id": 0}
+{"abstract_id": "26006702", "label": "objective", "text": "Megestrol acetate and abiraterone generally show variability in absorption and , depending on the formulation , food effect .", "sentence_id": 1}
+{"abstract_id": "26006702", "label": "objective", "text": "This study was conducted to determine the effect of food on @mg oral immediate-release ( IR ) onapristone and to help identify a formulation to minimize variability .", "sentence_id": 2}
+{"abstract_id": "26006702", "label": "methods", "text": "This is an open-label , randomized , crossover study to determine the pharmacokinetic profile of onapristone and its main metabolite , N-mono-desmethyl onapristone .", "sentence_id": 3}
+{"abstract_id": "26006702", "label": "methods", "text": "Twelve healthy female subjects received @mg of oral IR onapristone after an overnight fast , or within @min of a high-fat , high-calorie meal with a @-week washout between dosing periods .", "sentence_id": 4}
+{"abstract_id": "26006702", "label": "results", "text": "Onapristone plasma t@/@ ( meanSD ) was @ h for the fasted state and @ h for the fed state .", "sentence_id": 5}
+{"abstract_id": "26006702", "label": "results", "text": "Following food , onapristone tmax was delayed from @ to @h .", "sentence_id": 6}
+{"abstract_id": "26006702", "label": "results", "text": "Food intake was also associated with a small increase in AUC@ - of approximately @ % and a statistically significant decrease in Cmax of approximately @ % .", "sentence_id": 7}
+{"abstract_id": "26006702", "label": "results", "text": "One subject experienced a @-day delay in menses after one @mg onapristone dose , while another subject experienced transient grade @ NCI-CTCAE liver enzyme elevation @weeks post dose .", "sentence_id": 8}
+{"abstract_id": "26006702", "label": "conclusions", "text": "The results are consistent with previous observations , indicating that there is a small increase in onapristone exposure and a significant decrease in Cmax when taken with food .", "sentence_id": 9}
+{"abstract_id": "26006702", "label": "conclusions", "text": "These changes are within acceptable limits set out by the FDA .", "sentence_id": 10}
+{"abstract_id": "26006702", "label": "conclusions", "text": "Thus , our findings indicate that onapristone could be administered without regard to food .", "sentence_id": 11}
+{"abstract_id": "25700292", "label": "objective", "text": "To review factors influencing placebo response and clinical trial outcome in depression , and suggest ways to optimize trial success in mood disorders .", "sentence_id": 0}
+{"abstract_id": "25700292", "label": "methods", "text": "PubMed searches were conducted by cross-referencing the terms depression , depressive with placebo , clinical trial , and clinical trials for studies published in English between @ and September @ .", "sentence_id": 1}
+{"abstract_id": "25700292", "label": "methods", "text": "Relevant abstracts were identified in PubMed , including clinical trials , quantitative studies , and qualitative research .", "sentence_id": 2}
+{"abstract_id": "25700292", "label": "methods", "text": "We obtained and reviewed relevant articles and utilized their information to synthesize the present review .", "sentence_id": 3}
+{"abstract_id": "25700292", "label": "methods", "text": "Included articles were grouped in the following areas of relevance : ( @ ) biological validity of illness , ( @ ) baseline severity of illness , ( @ ) chronicity of the index episode of depression , ( @ ) age of participants , ( @ ) medical and psychiatric comorbidity , ( @ ) probability of receiving placebo , ( @ ) use of prospective treatment phases ( lead-in ) ( @ ) dosing schedule , ( @ ) trial duration , ( @ ) frequency of follow-up assessments , and ( @ ) study outcome measure .", "sentence_id": 4}
+{"abstract_id": "25700292", "label": "results", "text": "Several key elements emerge as critical to the ultimate success of a clinical trial , including the probability of receiving placebo , study duration , dosing schedule , visit frequency , the use of blinded lead-in phases , the use of centralized raters , illness severity and duration , and comorbid anxiety .", "sentence_id": 5}
+{"abstract_id": "25700292", "label": "conclusions", "text": "Our increasing understanding of the placebo response in clinical trials of major depressive disorder lends to a , gradually , more predictable phenomenon and , hopefully , to one that becomes lesser in magnitude and variability .", "sentence_id": 6}
+{"abstract_id": "25700292", "label": "conclusions", "text": "Several elements have emerged that seem to play a critical role in trial success , gradually reshaping the design of clinical , translational , as well as mechanistic studies in depression .", "sentence_id": 7}
+{"abstract_id": "25216556", "label": "background", "text": "Repetitive transcranial magnetic stimulation ( rTMS ) is a noninvasive tool for modulating cortical activity .", "sentence_id": 0}
+{"abstract_id": "25216556", "label": "objective", "text": "In this pilot study , we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus ( IFG ) on cognitive functions in patients with amnestic mild cognitive impairment ( MCI ) or incipient dementia due to Alzheimer 's disease ( AD ) .", "sentence_id": 1}
+{"abstract_id": "25216556", "label": "methods", "text": "Ten patients ( @ men ; @ women , mean age of @ @ years ; MMSE @ @ ) were enrolled in a randomized , placebo-controlled study with a crossover design .", "sentence_id": 2}
+{"abstract_id": "25216556", "label": "methods", "text": "All participants received @ sessions of @ Hz rTMS over the non-dominant right hemisphere in random order : IFG ( active stimulation site ) and vertex ( control stimulation site ) .", "sentence_id": 3}
+{"abstract_id": "25216556", "label": "methods", "text": "Intensities were adjusted to @ % of resting motor threshold .", "sentence_id": 4}
+{"abstract_id": "25216556", "label": "methods", "text": "A total of @ pulses were applied in a session .", "sentence_id": 5}
+{"abstract_id": "25216556", "label": "methods", "text": "The Trail Making Test ( TMT ) , the Stroop test , and the complex visual scene encoding task ( CVSET ) were administered before and immediately after each session .", "sentence_id": 6}
+{"abstract_id": "25216556", "label": "methods", "text": "The Wilcoxon paired test was used for data analysis .", "sentence_id": 7}
+{"abstract_id": "25216556", "label": "results", "text": "Stimulation applied over the IFG induced improvement in the TMT parts A ( p = @ ) and B ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25216556", "label": "results", "text": "No significant changes were found in the Stroop test or the CVSET after the IFG stimulation .", "sentence_id": 9}
+{"abstract_id": "25216556", "label": "results", "text": "We observed no significant cognitive aftereffects of rTMS applied over the vertex .", "sentence_id": 10}
+{"abstract_id": "25216556", "label": "conclusions", "text": "High frequency rTMS of the right IFG induced significant improvement of attention and psychomotor speed in patients with MCI/mild dementia due to AD .", "sentence_id": 11}
+{"abstract_id": "25216556", "label": "conclusions", "text": "This pilot study is part of a more complex protocol and ongoing research .", "sentence_id": 12}
+{"abstract_id": "25588782", "label": "objective", "text": "To estimate the efficacy of a probiotic yogurt compared to a pasteurised yogurt for the prevention of antibiotic-associated diarrhoea in children .", "sentence_id": 0}
+{"abstract_id": "25588782", "label": "methods", "text": "This was a multisite , randomised , double-blind , placebo-controlled clinical trial conducted between September @ and @ .", "sentence_id": 1}
+{"abstract_id": "25588782", "label": "methods", "text": "The study was conducted through general practices and pharmacies in Launceston , Tasmania , Australia .", "sentence_id": 2}
+{"abstract_id": "25588782", "label": "methods", "text": "Children ( aged @-@years ) prescribed antibiotics , were randomised to receive @g/day of either yogurt ( probiotic ) containing Lactobacillus rhamnosus GG ( LGG ) , Bifidobacterium lactis ( Bb-@ ) and Lactobacillus acidophilus ( La-@ ) or a pasteurised yogurt ( placebo ) for the same duration as their antibiotic treatment .", "sentence_id": 3}
+{"abstract_id": "25588782", "label": "results", "text": "Stool frequency and consistency were recorded for the duration of treatment plus @week .", "sentence_id": 4}
+{"abstract_id": "25588782", "label": "results", "text": "Primary outcome was stool frequency and consistency , classified at different levels of diarrhoea severity .", "sentence_id": 5}
+{"abstract_id": "25588782", "label": "results", "text": "Due to the small number of cases of diarrhoea , comparisons between groups were made using Fisher 's exact analysis .", "sentence_id": 6}
+{"abstract_id": "25588782", "label": "results", "text": "@ children commenced and @ children ( @ placebo and @ probiotic ) completed the trial .", "sentence_id": 7}
+{"abstract_id": "25588782", "label": "results", "text": "There were no incidents of severe diarrhoea ( stool consistency @ , @ stools/day for @ consecutive days ) in the probiotic group and six in the placebo group ( Fisher 's exact p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25588782", "label": "results", "text": "There was also only one episode of minor diarrhoea ( stool consistency @ , @ stools/day for @days in the probiotic group compared to @ in the placebo group ( Fisher 's exact p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25588782", "label": "results", "text": "The probiotic group reported fewer adverse events ( @ had abdominal pain , @ vomited and @ had headache ) than the placebo group ( @ had abdominal pain , @ had loss of appetite and @ had nausea ) .", "sentence_id": 10}
+{"abstract_id": "25588782", "label": "conclusions", "text": "A yogurt combination of LGG , La-@ and Bb-@ is an effective method for reducing the incidence of antibiotic-associated diarrhoea in children .", "sentence_id": 11}
+{"abstract_id": "25835622", "label": "objective", "text": "The clinical benefits and risks of dose escalation ( DE ) for stage III non-small-cell lung cancer ( NSCLC ) remain uncertain despite the results from Radiation Therapy Oncology Group ( RTOG ) protocol @ .", "sentence_id": 0}
+{"abstract_id": "25835622", "label": "objective", "text": "There is significant heterogeneity of practice , with many clinicians prescribing intermediate dose levels between the @ study arms of @ and @ Gy .", "sentence_id": 1}
+{"abstract_id": "25835622", "label": "objective", "text": "This study investigated whether this strategy is associated with any survival benefits/risks by analyzing a large multi-institutional database .", "sentence_id": 2}
+{"abstract_id": "25835622", "label": "methods", "text": "An individual patient database of stage III NSCLC patients treated with radical intent concurrent chemoradiation therapy was created ( @ institutions , n = @ patients ) .", "sentence_id": 3}
+{"abstract_id": "25835622", "label": "methods", "text": "Patients were divided into @ groups based on tumor Biological Effective Dose at @ Gy ( BED @ ) : those receiving standard dose ( SD ; n = @ ) , consisting of @Gy BED @ @ Gy ( eg @-@ Gy/@ -@ fractions -LSB- fr -RSB- ) , and those receiving intermediate dose ( ID ; n = @ ) , consisting of @ Gy < BED @ < @ Gy ( eg > @ Gy/@ fr and < @ Gy/@ fr ) , with lower-dose patients ( n = @ ) excluded from consideration .", "sentence_id": 4}
+{"abstract_id": "25835622", "label": "methods", "text": "Patients were then matched using propensity scores , leading to @ matched groups of @ patients .", "sentence_id": 5}
+{"abstract_id": "25835622", "label": "methods", "text": "Outcomes were compared using various statistics including interquartile range ( IQR ) , Kaplan-Meier curves , and adjusted Cox regression analysis .", "sentence_id": 6}
+{"abstract_id": "25835622", "label": "results", "text": "Matched groups were found to be balanced except for N stage ( more N@ disease in SD ) , median treatment year ( SD in @ ; ID in @ ) , platinum and taxane chemotherapy ( SD in @ % ; ID in @ % ) , and median follow-up ( SD were @ months ; ID were @ months ) .", "sentence_id": 7}
+{"abstract_id": "25835622", "label": "results", "text": "Median dose fractionation was @ Gy/@ fr in SD ( BED @ IQR : @-@ @ Gy ) and @ Gy/@ fr ( BED @ IQR : @-@ @ Gy ) in ID .", "sentence_id": 8}
+{"abstract_id": "25835622", "label": "results", "text": "Survival curves for SD and ID matched cohorts were statistically similar ( P = @ ) ; however , a nonstatistically significant trend toward better survival for ID was observed after @ months ( median survival SD : @ months ; ID : @ months ) .", "sentence_id": 9}
+{"abstract_id": "25835622", "label": "results", "text": "There was an increase in grades III to V lung toxicity associated with ID ( @ % vs @ % , respectively ) .", "sentence_id": 10}
+{"abstract_id": "25835622", "label": "conclusions", "text": "No significant overall survival benefits were found with intermediate DE ; however , more grade III or greater lung toxicity was observed .", "sentence_id": 11}
+{"abstract_id": "25835622", "label": "conclusions", "text": "The separation of survival curves after @ months of follow-up suggests that a small overall survival improvement associated with intermediate DE can not be excluded .", "sentence_id": 12}
+{"abstract_id": "25093868", "label": "background", "text": "Hochuekkito , a traditional herbal medicine , is occasionally prescribed in Japan to treat patients with a poor general condition .", "sentence_id": 0}
+{"abstract_id": "25093868", "label": "background", "text": "We aimed to examine whether this medicine was beneficial and tolerable for patients with progressed pulmonary Mycobacterium avium complex ( MAC ) disease .", "sentence_id": 1}
+{"abstract_id": "25093868", "label": "methods", "text": "This pilot open-label quasi-randomized controlled trial enrolled @ patients with progressed pulmonary MAC disease who had initiated antimycobacterial treatment over one year ago but were persistently culture-positive or intolerant .", "sentence_id": 2}
+{"abstract_id": "25093868", "label": "methods", "text": "All patients continued their baseline treatment regimens with ( n = @ ) or without ( n = @ ) oral Hochuekkito for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25093868", "label": "results", "text": "Baseline characteristics were generally similar between the groups .", "sentence_id": 4}
+{"abstract_id": "25093868", "label": "results", "text": "Most patients were elderly ( median age @ years ) , female , had a low body mass index ( < @ kg/m@ ) , and a long-term disease duration ( median approximately @ years ) .", "sentence_id": 5}
+{"abstract_id": "25093868", "label": "results", "text": "After the @-week treatment period , no patient achieved sputum conversion .", "sentence_id": 6}
+{"abstract_id": "25093868", "label": "results", "text": "Although the number of colonies in sputum tended to increase in the control group , it generally remained stable in the Hochuekkito group .", "sentence_id": 7}
+{"abstract_id": "25093868", "label": "results", "text": "Radiological disease control was frequently observed in the Hochuekkito group than the control group ( @/@ vs. @/@ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25093868", "label": "results", "text": "Patients in the Hochuekkito group tended to experience increase in body weight and serum albumin level compared with those in the control group ( median body weight change : +@ kg vs. -@ kg ; median albumin change : +@ g/dl vs. @ g/dl ) .", "sentence_id": 9}
+{"abstract_id": "25093868", "label": "results", "text": "No severe adverse events occurred .", "sentence_id": 10}
+{"abstract_id": "25093868", "label": "conclusions", "text": "Hochuekkito could be an effective , feasible adjunct to conventional therapy for patients with progressed pulmonary MAC disease .", "sentence_id": 11}
+{"abstract_id": "25093868", "label": "conclusions", "text": "Future study is needed to explore this possibility .", "sentence_id": 12}
+{"abstract_id": "24647511", "label": "background", "text": "While animal studies have shown better healing with a longer duration of protection without motion exercise after rotator cuff repair , supporting clinical studies are rare .", "sentence_id": 0}
+{"abstract_id": "24647511", "label": "background", "text": "The purpose of this study was to assess the effect of immobilization following rotator cuff repair and to determine whether there was any difference in clinical outcome related to the duration of immobilization .", "sentence_id": 1}
+{"abstract_id": "24647511", "label": "methods", "text": "One hundred patients who underwent arthroscopic single-row repair of a posterosuperior rotator cuff tear ( mean , @ cm in the coronal-oblique plane and @ cm in the sagittal-oblique plane ) were prospectively randomized to be treated with immobilization for four or eight weeks .", "sentence_id": 2}
+{"abstract_id": "24647511", "label": "methods", "text": "During the immobilization period , no passive or active range-of-motion exercise , including pendulum exercise , was allowed .", "sentence_id": 3}
+{"abstract_id": "24647511", "label": "methods", "text": "According to the intention-to-treat protocol and full analysis set , eighty-eight patients were evaluated clinically and with magnetic resonance imaging postoperatively , after exclusion of twelve patients without postoperative clinical evaluation .", "sentence_id": 4}
+{"abstract_id": "24647511", "label": "methods", "text": "Ranges of motion , clinical scores , and retear rates were compared between the four and eight-week groups .", "sentence_id": 5}
+{"abstract_id": "24647511", "label": "methods", "text": "Ninety-eight patients were contacted by telephone at a mean of thirty-five months to investigate the clinical outcomes .", "sentence_id": 6}
+{"abstract_id": "24647511", "label": "results", "text": "The mean duration of immobilization was @ weeks in the four-week group and @ weeks in the eight-week group .", "sentence_id": 7}
+{"abstract_id": "24647511", "label": "results", "text": "There were nine full-thickness retears ( @ % ) , and @ % of the patients rated their result as excellent or good .", "sentence_id": 8}
+{"abstract_id": "24647511", "label": "results", "text": "There were five full-thickness retears in the four-week group and four in the eight-week group ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24647511", "label": "results", "text": "At the time of final follow-up , the two groups showed no differences in range of motion or clinical scores .", "sentence_id": 10}
+{"abstract_id": "24647511", "label": "results", "text": "However , the proportion showing stiffness was higher in the eight-week group ( @ % compared with @ % , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24647511", "label": "conclusions", "text": "Eight weeks of immobilization did not yield a higher rate of healing of medium-sized rotator cuff tears compared with four weeks of immobilization .", "sentence_id": 12}
+{"abstract_id": "24921919", "label": "background", "text": "The optimal treatment for localised oesophageal squamous cell carcinoma ( SCC ) is uncertain .", "sentence_id": 0}
+{"abstract_id": "24921919", "label": "background", "text": "We assessed the feasibility of an RCT comparing neoadjuvant treatment and surgery with definitive chemoradiotherapy .", "sentence_id": 1}
+{"abstract_id": "24921919", "label": "methods", "text": "A feasibility RCT in three centres examined incident patients and reasons for ineligibility using multi-disciplinary team meeting records .", "sentence_id": 2}
+{"abstract_id": "24921919", "label": "methods", "text": "Eligible patients were offered participation in the RCT with integrated qualitative research involving audio-recorded recruitment appointments and interviews with patients to inform recruitment training for staff .", "sentence_id": 3}
+{"abstract_id": "24921919", "label": "results", "text": "Of @ patients with oesophageal SCC , @ ( @ % ) were eligible .", "sentence_id": 4}
+{"abstract_id": "24921919", "label": "results", "text": "Reasons for eligibility varied between centres , with significantly differing proportions of patients excluded because of total tumour length ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24921919", "label": "results", "text": "Analyses of audio-recordings and patient interviews showed that recruiters had challenges articulating the trial design in simple terms , balancing treatment arms and explaining the need for randomisation .", "sentence_id": 6}
+{"abstract_id": "24921919", "label": "results", "text": "Before analyses of the qualitative data and recruiter training no patients were randomised .", "sentence_id": 7}
+{"abstract_id": "24921919", "label": "results", "text": "Following training in one centre @ of @ eligible patients were randomised .", "sentence_id": 8}
+{"abstract_id": "24921919", "label": "conclusions", "text": "An RCT of surgical vs non-surgical treatment for SCC of the oesophagus is not feasible in the UK alone because of the low number of incident eligible patients .", "sentence_id": 9}
+{"abstract_id": "24921919", "label": "conclusions", "text": "A trial comparing diverse treatment approaches may be possible with investment to support the recruitment process .", "sentence_id": 10}
+{"abstract_id": "24699550", "label": "objective", "text": "We aimed to investigate the effects of verapamil and adenosine in an adjunct to intravenous tirofiban on management and prognosis of no-reflow phenomenon during primary percutaneous coronary intervention ( PPCI ) and to compare their efficacies on reversing of no-reflow phenomenon and short and midterm survival .", "sentence_id": 0}
+{"abstract_id": "24699550", "label": "methods", "text": "We included @ patients with acute ST-segment elevation myocardial infarction ( STEMI ) and occurrence of no-reflow phenomenon after PPCI .", "sentence_id": 1}
+{"abstract_id": "24699550", "label": "methods", "text": "All patients received intravenous tirofiban and then randomized into one of the following @ groups : intracoronary adenosine ( N. = @ ) , intracoronary verapamil ( N. = @ ) or placebo ( N. = @ ) .", "sentence_id": 2}
+{"abstract_id": "24699550", "label": "results", "text": "Intracoronary verapamil therapy had significant effect in restoring impaired coronary blood flow by decreasing thrombolysis in myocardial infarction ( TIMI ) frame count from @ to @ ( P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24699550", "label": "results", "text": "However , adenosine and serum physiologic administration were not found to be so effective in decreasing TIMI frame count ( from @ to @ , P = @ ; from @ to @ , P = @ , respectively ) .", "sentence_id": 4}
+{"abstract_id": "24699550", "label": "results", "text": "In-hospital and @-month survival rates were similar among groups .", "sentence_id": 5}
+{"abstract_id": "24699550", "label": "conclusions", "text": "In conclusion , intracoronary verapamil restored the impaired coronary blood flow more effectively than adenosine or placebo .", "sentence_id": 6}
+{"abstract_id": "24699550", "label": "conclusions", "text": "However , none of them has changed the clinical course in the first @ months .", "sentence_id": 7}
+{"abstract_id": "25440375", "label": "background", "text": "Dyslipidemia is an established feature of metabolic syndrome ( MS ) that is associated with an increased risk of atherosclerotic cardiovascular disease .", "sentence_id": 0}
+{"abstract_id": "25440375", "label": "background", "text": "Curcuminoids are natural products with anti-atherosclerotic and lipid-modifying effects but their efficacy in patients with MS has not yet been tested .", "sentence_id": 1}
+{"abstract_id": "25440375", "label": "objective", "text": "To investigate the effects of bioavailability-enhanced curcuminoids , as adjunctive to standard of care , on serum lipid concentrations in patients with MS.", "sentence_id": 2}
+{"abstract_id": "25440375", "label": "methods", "text": "Patients diagnosed with MS according to the NCEP-ATPIII criteria who were receiving standard of care were assigned to either curcuminoids ( C@ complex ( ) ; @ mg/day ; n = @ ) or placebo ( n = @ ; matched with drug capsules in shape and color ) for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25440375", "label": "methods", "text": "In order to improve the oral bioavailability , curcuminoids were co-administered with piperine ( bioperine ( ) ) in a ratio of @:@ .", "sentence_id": 4}
+{"abstract_id": "25440375", "label": "methods", "text": "Serum concentrations of total cholesterol , low-density lipoprotein cholesterol ( LDL-C ) , high-density lipoprotein cholesterol ( HDL-C ) , triglycerides , small dense LDL ( sdLDL ) , lipoprotein ( a ) -LSB- Lp ( a ) -RSB- , and non-HDL-C were determined at baseline and at the end of @-week treatment period .", "sentence_id": 5}
+{"abstract_id": "25440375", "label": "results", "text": "Curcuminoids were more effective than placebo in reducing serum LDL-C , non-HDL-C , total cholesterol , triglycerides and Lp ( a ) , and elevating HDL-C concentrations .", "sentence_id": 6}
+{"abstract_id": "25440375", "label": "results", "text": "However , changes in serum sdLDL levels were found to be comparable between the study groups .", "sentence_id": 7}
+{"abstract_id": "25440375", "label": "results", "text": "The effects of curcuminoids on triglycerides , non-HDL-C , total cholesterol and Lp ( a ) remained significant after adjustment for baseline values of lipids and body mass index .", "sentence_id": 8}
+{"abstract_id": "25440375", "label": "conclusions", "text": "Curcuminoids-piperine combination is an efficacious adjunctive therapy in patients with MS and can modify serum lipid concentrations beyond what is achieved with standard of care .", "sentence_id": 9}
+{"abstract_id": "24549966", "label": "objective", "text": "A few studies focused on the methods of treatment for displaced distal tibial shaft fractures have been published , all of which compared two different methods .", "sentence_id": 0}
+{"abstract_id": "24549966", "label": "objective", "text": "In this randomized , prospective study , we aimed to compare minimally invasive plate osteosynthesis , locking intramedullary nail stabilization and external fixation combined with limited open reduction and absorbable internal fixation for distal tibial shaft fractures by assessing complications and secondary procedures .", "sentence_id": 1}
+{"abstract_id": "24549966", "label": "methods", "text": "From November @ to June @ , @ skeletally mature patients with displaced distal tibial shaft fractures with or without fibula fracture were randomized to be treated by minimally invasive plate osteosynthesis ( group A , n = @ ) , locking intramedullary nail ( group B , n = @ ) or external fixation combined with limited open reduction and absorbable internal fixation ( group C , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24549966", "label": "methods", "text": "Age , gender , mechanism of injury , fracture pattern and presence of open fracture were equally distributed among the three groups .", "sentence_id": 3}
+{"abstract_id": "24549966", "label": "methods", "text": "Indexes for evaluation included hospital stay , operative time , time to radiographic union , union status , infection and the incidence of re-operation .", "sentence_id": 4}
+{"abstract_id": "24549966", "label": "methods", "text": "Mazur ankle score was introduced for functional evaluation .", "sentence_id": 5}
+{"abstract_id": "24549966", "label": "methods", "text": "Statistics Analysis System ( SAS ) @ was used for analysis .", "sentence_id": 6}
+{"abstract_id": "24549966", "label": "results", "text": "A total of @ patients were included in the final analysis ( group A @ , group B @ and group C @ ) and evaluated after a mean of @ months follow-up .", "sentence_id": 7}
+{"abstract_id": "24549966", "label": "results", "text": "There was no significant difference ( P > @ ) in hospital stay , time to radiographic union and the incidence of union status among the three groups .", "sentence_id": 8}
+{"abstract_id": "24549966", "label": "results", "text": "Although group C was associated with less secondary procedures versus groups A and B , it was related with more pin tract infections ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24549966", "label": "results", "text": "Anterior knee pain occurred frequently after locking intramedullary nailing ( @ % ) and the irritation symptoms were more frequently encountered in group A ( @ % ) .", "sentence_id": 10}
+{"abstract_id": "24549966", "label": "results", "text": "There was no difference in ankle function between the three methods after operation ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "24549966", "label": "conclusions", "text": "We consider that the minimally invasive plate osteosynthesis , locking intramedullary nail stabilization and external fixation combined with limited open reduction and absorbable internal fixation techniques are all efficient methods for treating distal tibia fractures .", "sentence_id": 12}
+{"abstract_id": "24549966", "label": "conclusions", "text": "With its wide indications , external fixation combined with limited open reduction and absorbable internal fixation leads to minimal soft tissue complication , good functional result and no local soft tissue irritation or implant removal .", "sentence_id": 13}
+{"abstract_id": "24439640", "label": "objective", "text": "To examine the effects of Reiki as an adjuvant therapy to opioid therapy for postoperative pain control in pediatric patients .", "sentence_id": 0}
+{"abstract_id": "24439640", "label": "methods", "text": "This was a double-blind , randomized controlled study of children undergoing dental procedures .", "sentence_id": 1}
+{"abstract_id": "24439640", "label": "methods", "text": "Participants were randomly assigned to receive either Reiki therapy or the control therapy ( sham Reiki ) preoperatively .", "sentence_id": 2}
+{"abstract_id": "24439640", "label": "methods", "text": "Postoperative pain scores , opioid requirements , and side effects were assessed .", "sentence_id": 3}
+{"abstract_id": "24439640", "label": "methods", "text": "Family members were also asked about perioperative care satisfaction .", "sentence_id": 4}
+{"abstract_id": "24439640", "label": "methods", "text": "Multiple linear regressions were used for analysis .", "sentence_id": 5}
+{"abstract_id": "24439640", "label": "results", "text": "Thirty-eight children participated .", "sentence_id": 6}
+{"abstract_id": "24439640", "label": "results", "text": "The blinding procedure was successful .", "sentence_id": 7}
+{"abstract_id": "24439640", "label": "results", "text": "No statistically significant difference was observed between groups on all outcome measures .", "sentence_id": 8}
+{"abstract_id": "24439640", "label": "conclusions", "text": "Our study provides a successful example of a blinding procedure for Reiki therapy among children in the perioperative period .", "sentence_id": 9}
+{"abstract_id": "24439640", "label": "conclusions", "text": "This study does not support the effectiveness of Reiki as an adjuvant therapy to opioid therapy for postoperative pain control in pediatric patients .", "sentence_id": 10}
+{"abstract_id": "24308572", "label": "background", "text": "A better understanding of interrelations of exercise and improved eating , and their psychosocial correlates of self-efficacy , mood , and self-regulation , may be useful for the architecture of improved weight loss treatments .", "sentence_id": 0}
+{"abstract_id": "24308572", "label": "background", "text": "Theory-based research within field settings , with samples possessing high probabilities of health risks , might enable rapid application of useful findings .", "sentence_id": 1}
+{"abstract_id": "24308572", "label": "methods", "text": "Adult volunteers with severe obesity ( body mass index -LSB- BMI -RSB- @-@ kg/m ; age = @ @ y ; @ % female ) were randomly assigned to six monthly cognitive-behavioral exercise support sessions paired with either group-based nutrition education ( n = @ ) or cognitive behavioral methods applied to improved eating ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24308572", "label": "methods", "text": "After specification of mediation models using a bias-corrected bootstrapping procedure , a series of reciprocal effects analyses assessed : a ) the reciprocal effects of changes in exercise and fruit and vegetable intake , resulting from the treatments , b ) the reciprocal effects of changes in the three psychosocial variables tested ( i.e. self-efficacy , mood , and self-regulation ) and fruit and vegetable change , resulting from change in exercise volume , and c ) the reciprocal effects of changes in the three psychosocial variables and exercise change , resulting from change in fruit and vegetable intake .", "sentence_id": 3}
+{"abstract_id": "24308572", "label": "results", "text": "Mediation analyses suggested a reciprocal effect between changes in exercise volume and fruit and vegetable intake .", "sentence_id": 4}
+{"abstract_id": "24308572", "label": "results", "text": "After inclusion of psychosocial variables , also found were reciprocal effects between change in fruit and vegetable intake and change in mood , self-efficacy for controlled eating , and self-regulation for eating ; and change in exercise volume and change in mood and exercise-related self-regulation .", "sentence_id": 5}
+{"abstract_id": "24308572", "label": "conclusions", "text": "Findings had implications for behavioral weight-loss theory and treatment .", "sentence_id": 6}
+{"abstract_id": "24308572", "label": "conclusions", "text": "Specifically , results suggested that treatments should focus upon , and leverage , the transfer effects from each of the primary weight-loss behaviors ( exercise and healthy eating ) to the other .", "sentence_id": 7}
+{"abstract_id": "24308572", "label": "conclusions", "text": "Findings on psychosocial correlates of these behavioral processes may also have practical applications .", "sentence_id": 8}
+{"abstract_id": "25805405", "label": "background", "text": "Accruing evidence suggests that positive imagery-based cognitive bias modification ( CBM ) could have potential as a standalone targeted intervention for depressive symptoms or as an adjunct to existing treatments .", "sentence_id": 0}
+{"abstract_id": "25805405", "label": "background", "text": "We sought to establish the benefit of this form of CBM when delivered prior to Internet cognitive behavioral therapy ( iCBT ) for depression", "sentence_id": 1}
+{"abstract_id": "25805405", "label": "methods", "text": "A randomized controlled trial ( RCT ) of a @-week Internet-delivered positive CBM vs. an active control condition for participants ( N = @ , @ % female , mean age = @ ) meeting diagnostic criteria for major depression ; followed by a @-week iCBT program for both groups .", "sentence_id": 2}
+{"abstract_id": "25805405", "label": "results", "text": "Modified intent-to-treat marginal and mixed effect models demonstrated no significant difference between conditions following the CBM intervention or the iCBT program .", "sentence_id": 3}
+{"abstract_id": "25805405", "label": "results", "text": "In both conditions there were significant reductions ( Cohens d @ -@ , @ % CI = @ -@ ) in primary measures of depression and interpretation bias ( PHQ@ , BDI-II , AST-D ) .", "sentence_id": 4}
+{"abstract_id": "25805405", "label": "results", "text": "Large effect size reductions ( Cohens d @ -@ , @ % CI = @ -@ ) were observed for secondary measures of distress , disability , anxiety and repetitive negative thinking ( K@ , WHODAS , STAI , RTQ ) .", "sentence_id": 5}
+{"abstract_id": "25805405", "label": "results", "text": "Per protocol analyses conducted in the sample of participants who completed all seven sessions of CBM indicated between-group superiority of the positive over control group on depression symptoms ( PHQ@ , BDI-II ) and psychological distress ( K@ ) following CBM ( Hedges g @ -@ , @ % CI = -@ -@ ) and following iCBT ( PHQ@ , K@ ) .", "sentence_id": 6}
+{"abstract_id": "25805405", "label": "results", "text": "The majority ( > @ % ) no longer met diagnostic criteria for depression at @-month follow-up .", "sentence_id": 7}
+{"abstract_id": "25805405", "label": "conclusions", "text": "The control condition contained many active components and therefore may have represented a smaller ` dose ' of the positive condition .", "sentence_id": 8}
+{"abstract_id": "25805405", "label": "conclusions", "text": "Results provide preliminary support for the successful integration of imagery-based CBM into an existing Internet-based treatment for depression .", "sentence_id": 9}
+{"abstract_id": "25776953", "label": "objective", "text": "Nonsevere relapses are more common than severe relapses in antineutrophil cytoplasmic antibody ( ANCA ) - associated vasculitis ( AAV ) , but their clinical course and treatment outcomes remain largely unexamined .", "sentence_id": 0}
+{"abstract_id": "25776953", "label": "objective", "text": "We undertook this study to analyze the outcomes of patients with nonsevere relapses in the Rituximab in ANCA-Associated Vasculitis ( RAVE ) trial who were treated with prednisone according to a prespecified protocol .", "sentence_id": 1}
+{"abstract_id": "25776953", "label": "methods", "text": "RAVE was a randomized , double-blind , placebo-controlled trial comparing rituximab ( RTX ) to cyclophosphamide ( CYC ) followed by azathioprine ( AZA ) for induction of remission .", "sentence_id": 2}
+{"abstract_id": "25776953", "label": "methods", "text": "Patients who experienced nonsevere relapses between months @ and @ were treated with a prednisone increase without a concomitant change in their nonglucocorticoid immunosuppressants , followed by a taper .", "sentence_id": 3}
+{"abstract_id": "25776953", "label": "results", "text": "Forty-four patients with a first nonsevere relapse were analyzed .", "sentence_id": 4}
+{"abstract_id": "25776953", "label": "results", "text": "In comparison to the @ patients who maintained relapse-free remission over @ months , these patients were more likely to have proteinase @-ANCAs , diagnoses of granulomatosis with polyangiitis ( Wegener 's ) , and a history of relapsing disease at baseline .", "sentence_id": 5}
+{"abstract_id": "25776953", "label": "results", "text": "A prednisone increase led to remission in @ patients ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25776953", "label": "results", "text": "However , only @ patients ( @ % ) were able to maintain second remissions through the followup period ( mean @ months ) ; @ patients ( @ % ) had a second disease relapse , @ of them with severe disease .", "sentence_id": 7}
+{"abstract_id": "25776953", "label": "results", "text": "The mean time to second relapse was @ months ( @ months in the group treated with RTX versus @ months in the group treated with CYC/AZA ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25776953", "label": "results", "text": "Patients who experienced nonsevere relapses received more glucocorticoids than those who maintained remission ( @ grams versus @ grams ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25776953", "label": "conclusions", "text": "Treatment of nonsevere relapses in AAV with an increase in glucocorticoids is effective in restoring temporary remission in the majority of patients , but recurrent relapses within a relatively short interval remain common .", "sentence_id": 10}
+{"abstract_id": "25776953", "label": "conclusions", "text": "Alternative treatment approaches are needed for this important subset of patients .", "sentence_id": 11}
+{"abstract_id": "24679695", "label": "background", "text": "The incidence of alkaline reflux gastritis ( ARG ) after pancreaticoduodenectomy ( PD ) is high .", "sentence_id": 0}
+{"abstract_id": "24679695", "label": "background", "text": "Although Braun enteroenterostomy ( BEE ) may reduce ARG , BEE may result in marginal ulcers ( MUs ) due to the additional anastomotic stoma .", "sentence_id": 1}
+{"abstract_id": "24679695", "label": "background", "text": "We conducted this study to compare clinical outcomes of using a modified BEE ( MBEE ) with traditional gastrojejunostomy ( TGJ ) , by inducting a purse-string suture instead of an additional anastomotic stoma .", "sentence_id": 2}
+{"abstract_id": "24679695", "label": "methods", "text": "All @ patients underwent standard PD at the Department of Hepatobiliopancreatic Surgery of West China Hospital between January @ , @ and January @ , @ .", "sentence_id": 3}
+{"abstract_id": "24679695", "label": "methods", "text": "Demographics , perioperative and postoperative factors , and follow-up morbidity were compared in those patients who underwent MBEE ( n = @ , three patients were lost to follow-up ) to those who underwent TGJ ( n = @ , nine patients were lost to follow-up ) .", "sentence_id": 4}
+{"abstract_id": "24679695", "label": "results", "text": "Patients who underwent the MBEE experienced a decrease in total morbidity including ARG and MUs , relative to those who underwent TGJ ( @ % versus @ % , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24679695", "label": "results", "text": "With regard to the MBEE group , the total ARG rate was statistically significantly lower compared with the TGJ group ( @ % versus @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24679695", "label": "results", "text": "In addition , the incidence of MUs was reduced .", "sentence_id": 7}
+{"abstract_id": "24679695", "label": "conclusions", "text": "In patients undergoing PD , the MBEE was safely performed with significantly more patients having reduced incidence of ARG and related sequela compared with those who underwent TGJ .", "sentence_id": 8}
+{"abstract_id": "24679695", "label": "conclusions", "text": "These results support further study of patients undergoing gastroenterostomy after resection of the distal stomach in larger , randomized studies .", "sentence_id": 9}
+{"abstract_id": "25659357", "label": "objective", "text": "To assess the effect of platelet-rich fibrin ( PRF ) on postoperative pain , swelling , trismus , periodontal healing on the distal aspect of the secondmolar , and progress of bone regeneration in mandibular third molar extraction sockets .", "sentence_id": 0}
+{"abstract_id": "25659357", "label": "methods", "text": "Over a @-year period , @ patients ( mean age , @ yr ) who required surgical extraction of a single impacted third molar and met the inclusion criteria were recruited .", "sentence_id": 1}
+{"abstract_id": "25659357", "label": "methods", "text": "After surgical extraction of the third molar , only primary closure was performed in the control group , whereas PRF was placed in the socket followed by primary closure in the case group ( @ patients ) .", "sentence_id": 2}
+{"abstract_id": "25659357", "label": "methods", "text": "The outcome variables were pain , swelling , maximum mouth opening , periodontal pocket depth , and bone formation , with a follow-up period of @months .", "sentence_id": 3}
+{"abstract_id": "25659357", "label": "methods", "text": "Quantitative data are presented as mean .", "sentence_id": 4}
+{"abstract_id": "25659357", "label": "methods", "text": "Statistical significance was inferred at a P value less than @ .", "sentence_id": 5}
+{"abstract_id": "25659357", "label": "results", "text": "Pain ( P = @ ) , swelling ( P = @ ) , and interincisal distance ( P = @ ) were less in the case group compared with the control group on the first postoperative day .", "sentence_id": 6}
+{"abstract_id": "25659357", "label": "results", "text": "Periodontal pocket depth decreased at @months postoperatively in the case ( P < @ ) and control ( P = @ ) groups , and this decrease was statistically significant .", "sentence_id": 7}
+{"abstract_id": "25659357", "label": "results", "text": "Bone density scores at @months postoperatively were higher in the case group than in the control group , but this difference was not statistically important .", "sentence_id": 8}
+{"abstract_id": "25659357", "label": "conclusions", "text": "The application of PRF lessens the severity of immediate postoperative sequelae , decreases preoperative pocket depth , and hastens bone formation .", "sentence_id": 9}
+{"abstract_id": "24886338", "label": "background", "text": "Vertigo is a common medical condition with a broad spectrum of diagnoses which requires an integrated approach to patients through a structured clinical interview and physical examination .", "sentence_id": 0}
+{"abstract_id": "24886338", "label": "background", "text": "The main cause of vertigo in primary care is benign paroxysmal positional vertigo ( BPPV ) , which should be confirmed by a positive D-H positional test and treated with repositioning maneuvers .", "sentence_id": 1}
+{"abstract_id": "24886338", "label": "background", "text": "The objective of this study is to evaluate the effectiveness of Epley 's maneuver performed by general practitioners ( GPs ) in the treatment of BPPV .", "sentence_id": 2}
+{"abstract_id": "24886338", "label": "methods", "text": "This study is a randomized clinical trial conducted in the primary care setting .", "sentence_id": 3}
+{"abstract_id": "24886338", "label": "methods", "text": "The study 's scope will include two urban primary care centers which provide care for approximately @,@ patients .", "sentence_id": 4}
+{"abstract_id": "24886338", "label": "methods", "text": "All patients attending these two primary care centers , who are newly diagnosed with benign paroxysmal positional vertigo , will be invited to participate in the study and will be randomly assigned either to the treatment group ( Epley 's maneuver ) or to the control group ( a sham maneuver ) .", "sentence_id": 5}
+{"abstract_id": "24886338", "label": "methods", "text": "Both groups will receive betahistine .", "sentence_id": 6}
+{"abstract_id": "24886338", "label": "methods", "text": "Outcome variables will be : response to the D-H test , patients ' report on presence or absence of vertigo during the previous week ( dichotomous variable : yes/no ) , intensity of vertigo symptoms on a Likert-type scale in the previous week , total score on the Dizziness Handicap Inventory ( DHI ) and quantity of betahistine taken .", "sentence_id": 7}
+{"abstract_id": "24886338", "label": "conclusions", "text": "Positive results from our study will highlight that treatment of benign paroxysmal positional vertigo can be performed by trained general practitioners ( GPs ) and , therefore , its widespread practice may contribute to improve the quality of life of BPPV patients .", "sentence_id": 8}
+{"abstract_id": "24296288", "label": "objective", "text": "The aim of this study was to develop an accurate robust testing method to simultaneously measure urine levels of HVA and VMA using gas chromatography mass spectrometry ( GCMS ) and to establish age-specific reference intervals of HVA and VMA in random urines for Vietnamese children .", "sentence_id": 0}
+{"abstract_id": "24296288", "label": "methods", "text": "The assay for urinary HVA and VMA was developed based on a classical urinary organic acid profiling method .", "sentence_id": 1}
+{"abstract_id": "24296288", "label": "methods", "text": "Briefly , this incorporated @-phenyl butyric acid as the internal standard and liquid-liquid extraction with ethyl acetate followed by derivatization with BSTFA .", "sentence_id": 2}
+{"abstract_id": "24296288", "label": "methods", "text": "The Agilent @A GC and @C Mass Selective Detector in single ion monitoring mode was used for analysis .", "sentence_id": 3}
+{"abstract_id": "24296288", "label": "methods", "text": "Reference intervals were developed from random urine samples collected from @ disease free Vietnamese children and compared to @ known neuroblastoma patient samples .", "sentence_id": 4}
+{"abstract_id": "24296288", "label": "methods", "text": "Results were reported relative to creatinine concentration .", "sentence_id": 5}
+{"abstract_id": "24296288", "label": "methods", "text": "Age related @ % reference intervals for urinary HVA and VMA were estimated from sample quantiles .", "sentence_id": 6}
+{"abstract_id": "24296288", "label": "methods", "text": "The analytes ( expressed as analyte/creatinine ratios ) diagnostic values were determined by calculating the related sensitivity , specificity and likelihood ratios .", "sentence_id": 7}
+{"abstract_id": "24296288", "label": "results", "text": "HVA and VMA were linear to at least @ and @mol/L , respectively .", "sentence_id": 8}
+{"abstract_id": "24296288", "label": "results", "text": "The limit of quantitation for both analytes was @ mol/L .", "sentence_id": 9}
+{"abstract_id": "24296288", "label": "results", "text": "Using the bi-level control ( n = @ ) , the within-batch coefficients of variations ( CVs ) were less than @ % for both analytes across the assay range .", "sentence_id": 10}
+{"abstract_id": "24296288", "label": "results", "text": "The between-batch CVs ( n = @ over three months ) , were @ % at @mol/L and @ % at @mol/L for HVA , @ % at @ mol/L and @ % at @ mol/L for VMA .", "sentence_id": 11}
+{"abstract_id": "24296288", "label": "results", "text": "Vietnamese age related reference intervals were established for urinary HVA and VMA per creatinine .", "sentence_id": 12}
+{"abstract_id": "24296288", "label": "results", "text": "HVA for children < @months ( n = @ ) was @-@ @ mol/mmol ; @months to < @year ( n = @ ) was @-@ @ mol/mmol ; @ to @years ( n = @ ) was @-@ @ mol/mmol ; @ to @years ( n = @ ) was @-@ @ mol/mmol ; and @ to @years ( n = @ ) was @-@ @ mol/mmol .", "sentence_id": 13}
+{"abstract_id": "24296288", "label": "results", "text": "VMA for children < @months was @-@ @ mol/mmol ; @months to < @year was @-@ @ mol/mmol ; @ to @years was @-@ @ mol/mmol ; @ to @years was @-@ @ mol/mmol ; and @ to @years was < @-@ @ mol/mmol .", "sentence_id": 14}
+{"abstract_id": "24296288", "label": "conclusions", "text": "A robust testing method for simultaneous quantitation of urinary HVA and VMA by GCMS was developed .", "sentence_id": 15}
+{"abstract_id": "24296288", "label": "conclusions", "text": "This method is accurate , precise and fit for its clinical purpose and suitable for developing countries .", "sentence_id": 16}
+{"abstract_id": "24296288", "label": "conclusions", "text": "Age-related reference intervals of urinary HVA and VMA were established for Vietnamese children and the intervals declined progressively with increasing age for each analyte .", "sentence_id": 17}
+{"abstract_id": "24511648", "label": "background", "text": "Contrast-induced nephropathy ( CIN ) is one of the major causes of new-onset renal failure in hospitalized patients .", "sentence_id": 0}
+{"abstract_id": "24511648", "label": "background", "text": "Although renin-angiotensin-aldosterone system ( RAAS ) blocking agents are widely used among patients requiring contrast studies , data on the effect of these agents on the development of CIN are sparse and inconsistent .", "sentence_id": 1}
+{"abstract_id": "24511648", "label": "objective", "text": "To evaluate in a randomized controlled trial whether uninterrupted administration of angiotensin II ( AnglI ) blockade medications influence estimated glomerular filtration rate ( eGFR ) in patients undergoing non-emergent coronary angiography .", "sentence_id": 2}
+{"abstract_id": "24511648", "label": "methods", "text": "Patients receiving treatment with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers ( ACE-I/ARB ) were recruited consecutively .", "sentence_id": 3}
+{"abstract_id": "24511648", "label": "methods", "text": "The enrolled subjects were randomized into three groups at a @:@:@ ratio : group A ( ACE/ARB stopped @ hours prior to the procedure and restarted immediately after the procedure ) , group B ( ACE/ARB stopped @ hours prior to the procedure and restarted @ hours after the procedure ) , and group C ( ACE/ARB continued throughout the study period ) .", "sentence_id": 4}
+{"abstract_id": "24511648", "label": "methods", "text": "Plasma creatinine was measured and eGFR was calculated according to the Cockroft-Gault equation before and @ hours after the coronary angiography .", "sentence_id": 5}
+{"abstract_id": "24511648", "label": "methods", "text": "The primary endpoint was a change in eGFR at @ hours .", "sentence_id": 6}
+{"abstract_id": "24511648", "label": "results", "text": "Groups A , B and C comprised @ , @ and @ patients respectively .", "sentence_id": 7}
+{"abstract_id": "24511648", "label": "results", "text": "The mean age of the study population was @ + / - @ years and @ % were males .", "sentence_id": 8}
+{"abstract_id": "24511648", "label": "results", "text": "Fifty percent of the subjects had diabetes mellitus .", "sentence_id": 9}
+{"abstract_id": "24511648", "label": "results", "text": "The primary endpoint analysis showed that at @ hours after the procedure there was no difference in delta eGFR between groups A and C ( @ + / - @ vs. @ + / - @ , P = @ ) and groups B and C ( @ + / - @ vs. @ + / - @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24511648", "label": "results", "text": "In post-hoc analysis the patients were clustered according to the following groups : medical alternation ( group A and B ) versus control ( group C ) , and to baseline eGFR > or = @ ml/min vs. eGFR ( < @ ml/min .", "sentence_id": 11}
+{"abstract_id": "24511648", "label": "results", "text": "In patients with baseline eGFR < @ ml/min the delta eGFR ( baseline eGFR-eGFR @ hours post-angiography ) was significantly different between the intervention vs. control group ( median @ vs. median -@ , P = @ respectively ) .", "sentence_id": 12}
+{"abstract_id": "24511648", "label": "results", "text": "While in patients with baseline eGFR > or = @ ml/min there was no significant difference in delta eGFR between the intervention and control groups .", "sentence_id": 13}
+{"abstract_id": "24511648", "label": "conclusions", "text": "ACE-I and ARB can safely be used before and after coronary angiography in patients with eGFR > or = @ ml/min .", "sentence_id": 14}
+{"abstract_id": "25731690", "label": "objective", "text": "The purpose of this study was to investigate the use of vaginal progesterone for the prevention of preterm delivery in twin pregnancies .", "sentence_id": 0}
+{"abstract_id": "25731690", "label": "methods", "text": "We conducted a prospective , randomized , double-blind , placebo-controlled trial that involved @ naturally conceived twin pregnancies among mothers with no history of preterm delivery who were receiving antenatal care at a single center .", "sentence_id": 1}
+{"abstract_id": "25731690", "label": "methods", "text": "Women with twin pregnancies between @ and @ weeks and @ days ' gestation were assigned randomly to daily vaginal progesterone ( @ mg ) or placebo ovules until @ weeks and @ days ' gestation .", "sentence_id": 2}
+{"abstract_id": "25731690", "label": "methods", "text": "The primary outcome was the difference in mean gestational age at delivery ; the secondary outcomes were the rate of spontaneous delivery at < @ weeks ' gestation and the rate of neonatal composite morbidity and mortality in the treatment and nontreatment groups .", "sentence_id": 3}
+{"abstract_id": "25731690", "label": "results", "text": "The baseline characteristics were similar in both groups .", "sentence_id": 4}
+{"abstract_id": "25731690", "label": "results", "text": "The final analysis included @ women in the progesterone group and @ in the placebo group .", "sentence_id": 5}
+{"abstract_id": "25731690", "label": "results", "text": "No difference ( P = @ ) in the mean gestational age at delivery was observed between progesterone ( @ @ -LSB- SD -RSB- ) and placebo groups ( @ @ ) .", "sentence_id": 6}
+{"abstract_id": "25731690", "label": "results", "text": "The incidence of spontaneous delivery at < @ weeks ' gestation was @ % in the progesterone group and @ % in the placebo group ( odds ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "25731690", "label": "results", "text": "No difference in the composite neonatal morbidity and mortality was observed between the progesterone ( @ % ) and placebo ( @ % ) groups ( odds ratio , @ ; @ % confidence interval , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25731690", "label": "conclusions", "text": "In nonselected twin pregnancies , vaginal progesterone administration does not prevent preterm delivery and does not reduce neonatal morbidity and death .", "sentence_id": 9}
+{"abstract_id": "24614995", "label": "objective", "text": "To investigate the effect of Vitamin D@ on physical performance in patients with HF .", "sentence_id": 0}
+{"abstract_id": "24614995", "label": "background", "text": "HF is associated with functional decline and frailty .", "sentence_id": 1}
+{"abstract_id": "24614995", "label": "background", "text": "Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF .", "sentence_id": 2}
+{"abstract_id": "24614995", "label": "methods", "text": "Sixty-four patients participated in a @-month parallel design double blind RCT to test the hypothesis that oral vitamin D@ would improve physical performance .", "sentence_id": 3}
+{"abstract_id": "24614995", "label": "methods", "text": "Vitamin D@ @,@ IU or placebo was given weekly ; all received daily calcium .", "sentence_id": 4}
+{"abstract_id": "24614995", "label": "methods", "text": "Patients were included regardless of EF and @OHD @ ng/ml .", "sentence_id": 5}
+{"abstract_id": "24614995", "label": "methods", "text": "The primary outcome was peak VO@ , and secondary outcomes were the @MW , TGUG and knee isokinetic muscle strength .", "sentence_id": 6}
+{"abstract_id": "24614995", "label": "methods", "text": "Between group comparisons were made using ANCOVA models that adjust for baseline measures .", "sentence_id": 7}
+{"abstract_id": "24614995", "label": "results", "text": "Patients were age @ @ years old , @ % women , @ % African American , EF @ , @ % NYHA III , the remainder NYHA II .", "sentence_id": 8}
+{"abstract_id": "24614995", "label": "results", "text": "At baseline the vitamin D group @OHD was @ @ ng/ml and increased to @ @ ng/ml ; in the placebo group baseline @OHD was @ @ ng/ml and decreased to @ @ ng/ml at @ months ( between groups p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24614995", "label": "results", "text": "There was no significant change from baseline to @ months in peak VO@ , @MW , TGUG or isokinetic muscle strength .", "sentence_id": 10}
+{"abstract_id": "24614995", "label": "conclusions", "text": "Vitamin D@ did not improve physical performance for patients with HF despite a robust increase in serum @OHD .", "sentence_id": 11}
+{"abstract_id": "24614995", "label": "conclusions", "text": "Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation .", "sentence_id": 12}
+{"abstract_id": "24477039", "label": "background", "text": "In nutritional studies , pigs are often used as models for humans because of nutritional and physiologic similarities .", "sentence_id": 0}
+{"abstract_id": "24477039", "label": "background", "text": "However , evidence supporting similar metabolic responses to nutritional interventions is lacking .", "sentence_id": 1}
+{"abstract_id": "24477039", "label": "objective", "text": "The objective was to establish whether pigs and humans respond similarly to a nutritional intervention .", "sentence_id": 2}
+{"abstract_id": "24477039", "label": "objective", "text": "Using metabolomics , we compared the acute metabolic response to @ test breads between conventional pigs ( growing ) and adult human subjects ( with the metabolic syndrome ) .", "sentence_id": 3}
+{"abstract_id": "24477039", "label": "methods", "text": "Six catheterized pigs and @ human subjects were tested in a randomized crossover design with @ breads : white-wheat bread low in dietary fiber , rye bread with whole-rye kernels , and @ white-wheat breads supplemented with either wheat arabinoxylan or oat - glucan .", "sentence_id": 4}
+{"abstract_id": "24477039", "label": "methods", "text": "Blood samples drawn -@ , @ , and @ min postprandially were analyzed by untargeted liquid chromatography-mass spectrometry metabolomics .", "sentence_id": 5}
+{"abstract_id": "24477039", "label": "results", "text": "We found that the postprandial responses , as reflected in blood metabolomes , are similar in pigs and humans .", "sentence_id": 6}
+{"abstract_id": "24477039", "label": "results", "text": "Twenty-one of @ identified metabolites that were found to be different between the species were qualitatively similar in response to the test breads , despite different basal metabolome concentrations in the plasma of pigs and humans .", "sentence_id": 7}
+{"abstract_id": "24477039", "label": "results", "text": "Humans had higher contents of phosphatidylcholines , oleic acid , and carnitine in plasma , possibly reflecting a higher intake of meats and fats .", "sentence_id": 8}
+{"abstract_id": "24477039", "label": "results", "text": "In pigs , betaine , choline , creatinine , tryptophan , and phenylalanine were higher , probably because of the higher doses of bread provided to the pigs ( per kg body weight ) and/or because of their growing status .", "sentence_id": 9}
+{"abstract_id": "24477039", "label": "results", "text": "Acute metabolic differences in these metabolites induced by the breads were , however , comparable between the @ species .", "sentence_id": 10}
+{"abstract_id": "24477039", "label": "conclusions", "text": "Our results indicate that pigs are a suitable model for human metabolic studies in food research .", "sentence_id": 11}
+{"abstract_id": "24477039", "label": "conclusions", "text": "The human trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 12}
+{"abstract_id": "24477039", "label": "conclusions", "text": "The animal experiment was conducted according to a license obtained by the Danish Animal Experiments Inspectorate , Ministry of Food , Agriculture and Fisheries , Danish Veterinary and Food Administration .", "sentence_id": 13}
+{"abstract_id": "24361242", "label": "background", "text": "The extent to which change in physical activity can modify the risk of cardiovascular disease in individuals at high cardiovascular risk is uncertain .", "sentence_id": 0}
+{"abstract_id": "24361242", "label": "background", "text": "We investigated whether baseline and change in objectively-assessed ambulatory activity is associated with the risk of a cardiovascular event in individuals at high cardiovascular risk with impaired glucose tolerance .", "sentence_id": 1}
+{"abstract_id": "24361242", "label": "methods", "text": "We assessed prospective data from the NAVIGATOR trial involving @ individuals with impaired glucose tolerance who were recruited in @ countries between January , @ , and January , @ .", "sentence_id": 2}
+{"abstract_id": "24361242", "label": "methods", "text": "Participants also either had existing cardiovascular disease ( if age @ years ) or at least one additional cardiovascular risk factor ( if age @ years ) .", "sentence_id": 3}
+{"abstract_id": "24361242", "label": "methods", "text": "Participants were followed-up for cardiovascular events ( defined as cardiovascular mortality , non-fatal stroke , or myocardial infarction ) for @ years on average and had ambulatory activity assessed by pedometer at baseline and @ months .", "sentence_id": 4}
+{"abstract_id": "24361242", "label": "methods", "text": "Adjusted Cox proportional hazard models quantified the association of baseline and change in ambulatory activity ( from baseline to @ months ) with the risk of a subsequent cardiovascular event , after adjustment for each other and potential confounding variables .", "sentence_id": 5}
+{"abstract_id": "24361242", "label": "methods", "text": "This study is registered with ClinicalTrials.govNCT@ .", "sentence_id": 6}
+{"abstract_id": "24361242", "label": "results", "text": "During @,@ person-years follow-up , @ cardiovascular events occurred .", "sentence_id": 7}
+{"abstract_id": "24361242", "label": "results", "text": "Baseline ambulatory activity ( hazard ratio -LSB- HR -RSB- per @ steps per day @ , @ % CI @-@ ) and change in ambulatory activity ( @ , @-@ ) were inversely associated with the risk of a cardiovascular event .", "sentence_id": 8}
+{"abstract_id": "24361242", "label": "results", "text": "Results for change in ambulatory activity were unaffected when also adjusted for changes in body-mass index and other potential confounding variables at @ months .", "sentence_id": 9}
+{"abstract_id": "24361242", "label": "conclusions", "text": "In individuals at high cardiovascular risk with impaired glucose tolerance , both baseline levels of daily ambulatory activity and change in ambulatory activity display a graded inverse association with the subsequent risk of a cardiovascular event .", "sentence_id": 10}
+{"abstract_id": "25282520", "label": "background", "text": "Homozygous familial hypercholesterolaemia is a rare , serious disorder caused by very low or absent plasma clearance of LDL , substantially raised LDL cholesterol , and accelerated development of cardiovascular disease .", "sentence_id": 0}
+{"abstract_id": "25282520", "label": "background", "text": "Conventional lipid-lowering treatments are modestly effective .", "sentence_id": 1}
+{"abstract_id": "25282520", "label": "background", "text": "Evolocumab , a monoclonal antibody to proprotein convertase subtilisin/kexin type @ ( PCSK@ ) , reduced LDL cholesterol by @ % in a pilot study .", "sentence_id": 2}
+{"abstract_id": "25282520", "label": "background", "text": "We now report results with evolocumab in a randomised , double-blind , placebo-controlled phase @ trial .", "sentence_id": 3}
+{"abstract_id": "25282520", "label": "methods", "text": "This randomised , double-blind , placebo-controlled phase @ trial was undertaken at @ sites in ten countries in North America , Europe , the Middle East , and South Africa .", "sentence_id": 4}
+{"abstract_id": "25282520", "label": "methods", "text": "@ eligible patients ( aged @ years ) with homozygous familial hypercholesterolaemia , on stable lipid-regulating therapy for at least @ weeks , and not receiving lipoprotein apheresis , were randomly allocated by a computer-generated randomisation sequence in a @:@ ratio to receive subcutaneous evolocumab @ mg or placebo every @ weeks for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25282520", "label": "methods", "text": "Randomisation was stratified by LDL cholesterol at screening ( < @ mmol/L or @ mmol/L ) and implemented by a computerised interactive voice-response system .", "sentence_id": 6}
+{"abstract_id": "25282520", "label": "methods", "text": "Patients , study personnel , and the funder were masked to treatment and to the efficacy results by the central laboratory not returning LDL cholesterol or any lipid results to the clinical sites after the baseline visit .", "sentence_id": 7}
+{"abstract_id": "25282520", "label": "methods", "text": "The primary endpoint was percentage change in ultracentrifugation LDL cholesterol from baseline at week @ compared with placebo , analysed by intention-to-treat .", "sentence_id": 8}
+{"abstract_id": "25282520", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25282520", "label": "results", "text": "Of the @ eligible patients randomly assigned to the two treatment groups , @ actually received the study drug and completed the study ( @ in the placebo group and @ in the evolocumab group ) .", "sentence_id": 10}
+{"abstract_id": "25282520", "label": "results", "text": "Compared with placebo , evolocumab significantly reduced ultracentrifugation LDL cholesterol at @ weeks by @ % ( @ % CI -@ % to -@ % ; p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25282520", "label": "results", "text": "Treatment-emergent adverse events occurred in ten ( @ % ) of @ patients in the placebo group and @ ( @ % ) of @ in the evolocumab group .", "sentence_id": 12}
+{"abstract_id": "25282520", "label": "results", "text": "No serious clinical or laboratory adverse events occurred , and no anti-evolocumab antibody development was detected during the study .", "sentence_id": 13}
+{"abstract_id": "25282520", "label": "conclusions", "text": "In patients with homozygous familial hypercholesterolaemia receiving stable background lipid-lowering treatment and not on apheresis , evolocumab @ mg administered every @ weeks was well tolerated and significantly reduced LDL cholesterol compared with placebo .", "sentence_id": 14}
+{"abstract_id": "25232073", "label": "background", "text": "Dynamic rehabilitation has been suggested to be an important part of nonoperative treatment of acute Achilles tendon rupture that results in functional outcome and rerupture rates comparable with those of operative treatment .", "sentence_id": 0}
+{"abstract_id": "25232073", "label": "background", "text": "However , the optimal role of weight-bearing during early rehabilitation remains unclear .", "sentence_id": 1}
+{"abstract_id": "25232073", "label": "background", "text": "The purpose of this study was to compare immediate weight-bearing with non-weight-bearing in a nonoperative dynamic treatment protocol for Achilles tendon rupture .", "sentence_id": 2}
+{"abstract_id": "25232073", "label": "methods", "text": "The study was conducted as a blinded , randomized , controlled , parallel superiority trial .", "sentence_id": 3}
+{"abstract_id": "25232073", "label": "methods", "text": "Patients eighteen to sixty years of age were eligible for inclusion .", "sentence_id": 4}
+{"abstract_id": "25232073", "label": "methods", "text": "Both groups were treated nonoperatively with controlled early motion .", "sentence_id": 5}
+{"abstract_id": "25232073", "label": "methods", "text": "The intervention group was allowed full weight-bearing from day one , and the control group was non-weight-bearing for six weeks .", "sentence_id": 6}
+{"abstract_id": "25232073", "label": "methods", "text": "The primary outcome was the Achilles tendon Total Rupture Score ( ATRS ) after one year .", "sentence_id": 7}
+{"abstract_id": "25232073", "label": "methods", "text": "Secondary outcomes included heel-rise work , health-related quality of life , and the rerupture rate .", "sentence_id": 8}
+{"abstract_id": "25232073", "label": "methods", "text": "Outcome assessors were blinded to the intervention .", "sentence_id": 9}
+{"abstract_id": "25232073", "label": "results", "text": "Thirty patients were randomized to each group ; twenty-nine in the weight-bearing group and twenty-seven in the control group were analyzed .", "sentence_id": 10}
+{"abstract_id": "25232073", "label": "results", "text": "The only significant difference between the groups was better health-related quality of life in the weight-bearing group at twelve months ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25232073", "label": "results", "text": "The mean ATRS at twelve months was @ in the weight-bearing group and @ in the control group ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25232073", "label": "results", "text": "At twelve months , the total heel-rise work performed by the injured limb relative to that by the uninjured limb was @ % in the weight-bearing group and @ % in the control group ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25232073", "label": "results", "text": "There were three reruptures in the weight-bearing group and two in the control group ( p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25232073", "label": "conclusions", "text": "The ATRS and heel-rise work results did not differ significantly between the groups .", "sentence_id": 15}
+{"abstract_id": "25232073", "label": "conclusions", "text": "The rerupture rate was @ % overall , and both groups had substantial functional deficits in the injured limb compared with the uninjured limb .", "sentence_id": 16}
+{"abstract_id": "25232073", "label": "conclusions", "text": "Immediate weight-bearing can be recommended as an option in the nonoperative treatment of Achilles tendon rupture .", "sentence_id": 17}
+{"abstract_id": "25091954", "label": "background", "text": "To evaluate the potential efficacy and safety of inner limiting membrane ( ILM ) staining with brilliant blue G ( BBG ) under air infusion .", "sentence_id": 0}
+{"abstract_id": "25091954", "label": "methods", "text": "@ patients , treated by one surgeon with macular hole or idiopathic epiretinal membrane were evaluated prospectively .", "sentence_id": 1}
+{"abstract_id": "25091954", "label": "methods", "text": "BBG was applied under air infusion in @ patients ( group @ ) , and injected into the vitreous cavity in @ ( group @ ) .", "sentence_id": 2}
+{"abstract_id": "25091954", "label": "methods", "text": "Main outcome measures were the chromaticity difference between the stained ILM and the unstained underlying retina , anatomical-functional outcomes and complications of the surgery .", "sentence_id": 3}
+{"abstract_id": "25091954", "label": "methods", "text": "Chromaticity difference was measured by an objective and quantitative analysis method to describe colour contrast strengths as they are perceived by the human eye .", "sentence_id": 4}
+{"abstract_id": "25091954", "label": "methods", "text": "Anatomical and functional outcomes were assessed using optical coherence tomography ( OCT ) , visual field analyses ( VFA ) and multifocal electroretinography ( mfERG ) .", "sentence_id": 5}
+{"abstract_id": "25091954", "label": "results", "text": "CIELAB scores showed a significantly superior contrast for group @ ( @ ) than group @ ( @ ) ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25091954", "label": "results", "text": "Visual acuity had increased in @ eyes and remained stable in @ eyes in group @ .", "sentence_id": 7}
+{"abstract_id": "25091954", "label": "results", "text": "In group @ , visual acuity had improved in @ patients and remained unchanged in @ patients .", "sentence_id": 8}
+{"abstract_id": "25091954", "label": "results", "text": "Based on postoperative OCT , anatomical success rate was @ % .", "sentence_id": 9}
+{"abstract_id": "25091954", "label": "results", "text": "During the follow-up period , mfERG and VFA demonstrated no case of BBG toxicity in either group .", "sentence_id": 10}
+{"abstract_id": "25091954", "label": "results", "text": "Cataract progression was the main postoperative complication ( six eyes in group @ and four eyes in group @ ) and did not show a significant difference between the groups ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25091954", "label": "conclusions", "text": "BBG under air infusion yields a significantly higher contrast staining and easy peeling of ILM associated with anatomical and functional improvement and no retinal toxicity after macular surgery .", "sentence_id": 12}
+{"abstract_id": "24559642", "label": "objective", "text": "To investigate whether a home-based rehabilitation program for community-dwelling older people with recent hip fracture is more effective than standard care in improving mobility recovery and reducing disability .", "sentence_id": 0}
+{"abstract_id": "24559642", "label": "methods", "text": "Randomized , controlled , parallel-group trial .", "sentence_id": 1}
+{"abstract_id": "24559642", "label": "methods", "text": "Rehabilitation in participants ' homes ; measurements in university-based laboratory and local hospital .", "sentence_id": 2}
+{"abstract_id": "24559642", "label": "methods", "text": "Clinical population of community-dwelling men and women ( aged @ + ) recovering from hip fracture .", "sentence_id": 3}
+{"abstract_id": "24559642", "label": "methods", "text": "Participants were randomly assigned into control ( n = @ ) or intervention ( n = @ ) groups on average @ @ days after discharge home .", "sentence_id": 4}
+{"abstract_id": "24559642", "label": "methods", "text": "A yearlong multicomponent home-based rehabilitation aimed at promoting mobility recovery and physical functional capacity after hip fracture .", "sentence_id": 5}
+{"abstract_id": "24559642", "label": "methods", "text": "The intervention included evaluation and modification of environmental hazards , guidance for safe walking , nonpharmacological pain management , a progressive home exercise program , physical activity counseling , and standard care .", "sentence_id": 6}
+{"abstract_id": "24559642", "label": "methods", "text": "Measurements were outlined according to the tiers of the disablement process , with the ability to negotiate stairs as the main outcome .", "sentence_id": 7}
+{"abstract_id": "24559642", "label": "methods", "text": "Prefracture ability to negotiate stairs was enquired at the hospital on average @ @ days after fracture .", "sentence_id": 8}
+{"abstract_id": "24559642", "label": "methods", "text": "Subsequently , current perceived ability to negotiate stairs was reported immediately before the intervention ( on average @ weeks after surgery ) and @ , @ , and @ months thereafter .", "sentence_id": 9}
+{"abstract_id": "24559642", "label": "methods", "text": "Other measurements included leg extension power deficit ( LEP ) , functional balance ( Berg Balance Scale ) and lower extremity performance ( Short Physical Performance Battery ) .", "sentence_id": 10}
+{"abstract_id": "24559642", "label": "methods", "text": "Effects of the intervention were analyzed with generalized estimation equations and longitudinal repeated measures mixture path models .", "sentence_id": 11}
+{"abstract_id": "24559642", "label": "results", "text": "The intervention reduced perceived difficulties in negotiating stairs ( interaction , group time P = @ ) from prefracture to @ months compared with the control condition .", "sentence_id": 12}
+{"abstract_id": "24559642", "label": "results", "text": "The mixture path model revealed that less difficulty in negotiating stairs at @ and @ months correlated with better functional balance at @ and @ months in the intervention group but not controls ( group difference P = @ and P < @ , respectively ) .", "sentence_id": 13}
+{"abstract_id": "24559642", "label": "conclusions", "text": "The individualized home-based rehabilitation program improved mobility recovery after hip fracture over standard care .", "sentence_id": 14}
+{"abstract_id": "24559642", "label": "conclusions", "text": "To be efficacious in reducing or reversing disability after hip fracture , rehabilitation needs to be individualized , include many components , be progressive , and span a sufficiently long period .", "sentence_id": 15}
+{"abstract_id": "24559642", "label": "conclusions", "text": "Current Controlled Trials ( ISRCTN@ ) .", "sentence_id": 16}
+{"abstract_id": "24671165", "label": "objective", "text": "Patients leaving residential treatment for alcohol use disorders are not typically offered evidence-based continuing care , although research suggests that continuing care is associated with better outcomes .", "sentence_id": 0}
+{"abstract_id": "24671165", "label": "objective", "text": "A smartphone-based application could provide effective continuing care .", "sentence_id": 1}
+{"abstract_id": "24671165", "label": "objective", "text": "To determine whether patients leaving residential treatment for alcohol use disorders with a smartphone application to support recovery have fewer risky drinking days than control patients .", "sentence_id": 2}
+{"abstract_id": "24671165", "label": "methods", "text": "An unmasked randomized clinical trial involving @ residential programs operated by @ nonprofit treatment organization in the Midwestern United States and @ residential programs operated by @ nonprofit organization in the Northeastern United States .", "sentence_id": 3}
+{"abstract_id": "24671165", "label": "methods", "text": "In total , @ patients who met the criteria for DSM-IV alcohol dependence when they entered residential treatment were randomized to treatment as usual ( n = @ ) or treatment as usual plus a smartphone ( n = @ ) with the Addiction-Comprehensive Health Enhancement Support System ( A-CHESS ) , an application designed to improve continuing care for alcohol use disorders .", "sentence_id": 4}
+{"abstract_id": "24671165", "label": "methods", "text": "Treatment as usual varied across programs ; none offered patients coordinated continuing care after discharge .", "sentence_id": 5}
+{"abstract_id": "24671165", "label": "methods", "text": "A-CHESS provides monitoring , information , communication , and support services to patients , including ways for patients and counselors to stay in contact .", "sentence_id": 6}
+{"abstract_id": "24671165", "label": "methods", "text": "The intervention and follow-up period lasted @ and @ months , respectively .", "sentence_id": 7}
+{"abstract_id": "24671165", "label": "methods", "text": "Risky drinking days -- the number of days during which a patient 's drinking in a @-hour period exceeded @ standard drinks for men and @ standard drinks for women , with standard drink defined as one that contains roughly @ g of pure alcohol ( @ oz of regular beer , @ oz of wine , or @ oz of distilled spirits ) .", "sentence_id": 8}
+{"abstract_id": "24671165", "label": "methods", "text": "Patients were asked to report their risky drinking days in the previous @ days on surveys taken @ , @ , and @ months after discharge from residential treatment .", "sentence_id": 9}
+{"abstract_id": "24671165", "label": "results", "text": "For the @ months of the intervention and @ months of follow-up , patients in the A-CHESS group reported significantly fewer risky drinking days than did patients in the control group , with a mean of @ vs @ days ( mean difference , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24671165", "label": "conclusions", "text": "The findings suggest that a multifeatured smartphone application may have significant benefit to patients in continuing care for alcohol use disorders .", "sentence_id": 11}
+{"abstract_id": "24359618", "label": "background", "text": "Hemostasis in thyroid surgery is of utmost importance for a successful surgery and an uneventful postoperative course .", "sentence_id": 0}
+{"abstract_id": "24359618", "label": "background", "text": "Our aim was to evaluate the effectiveness of the FOCUS Harmonic Scalpel in patients undergoing open total thyroidectomy .", "sentence_id": 1}
+{"abstract_id": "24359618", "label": "methods", "text": "In this study , @ patients were randomized into @ groups based on the surgical technique used : group I comprised the conventional clamp-and-tie technique , group II comprised patients in whom the FOCUS Harmonic Scalpel was used exclusively .", "sentence_id": 2}
+{"abstract_id": "24359618", "label": "methods", "text": "The groups were compared in regard to surgical time , complications , and hospital stay .", "sentence_id": 3}
+{"abstract_id": "24359618", "label": "results", "text": "Surgical time was significantly lower in group II compared with group I ( @ min vs. @ , respectively , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24359618", "label": "results", "text": "Twenty-seven patients ( @ % ) in group I experienced symptomatic hypocalcemia requiring calcium and/or vitamin D therapy versus @ patients ( @ % ) in group II , with statistically significant difference ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24359618", "label": "results", "text": "Mean post-operative hospital stay was significantly lower in group II compared with group I ( @ vs. @ ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24359618", "label": "conclusions", "text": "The FOCUS Harmonic Scalpel can shorten operative time and hospital stay , reduce incidence of symptomatic hypocalcemia but not transient hypoparathyroidism , and show no significance on recurrent nerve injury .", "sentence_id": 7}
+{"abstract_id": "24359618", "label": "conclusions", "text": "FOCUS Harmonic Scalpel is supposed to be a more reliable and safe instrument that can take place of the clamp-and-tie technique in total thyroidectomy .", "sentence_id": 8}
+{"abstract_id": "24246119", "label": "objective", "text": "This study aimed at evaluating the benefit of changing drug therapy in elderly patients with moderate , potentially drug-induced hyponatremia .", "sentence_id": 0}
+{"abstract_id": "24246119", "label": "methods", "text": "Hospitalized older adults , with moderate hyponatremia , potentially induced by drugs , were randomized into two arms : an interventional group , whose drug therapy was changed , and a reference group , which received standard care .", "sentence_id": 1}
+{"abstract_id": "24246119", "label": "methods", "text": "The effectiveness of the intervention was evaluated by the normalization of serum sodium after four weeks and by the incidence of falls three months later .", "sentence_id": 2}
+{"abstract_id": "24246119", "label": "results", "text": "Nineteen patients were randomized , fourteen evaluated at @ weeks .", "sentence_id": 3}
+{"abstract_id": "24246119", "label": "results", "text": "Serum sodium was normalized more frequently in the interventional group than in the reference group : @ % ( @/@ ) IC@ % -LSB- @-@ -RSB- versus @ % ( @/@ ) IC@ % -LSB- @-@ -RSB- ; p = @ .", "sentence_id": 4}
+{"abstract_id": "24246119", "label": "results", "text": "A greater reduction in falls occurred in the therapeutic intervention group @ % ( @/@ ) IC@ % -LSB- @-@ -RSB- versus @ % ( @/@ ) IC@ % -LSB- @-@ -RSB- ; p = @ .", "sentence_id": 5}
+{"abstract_id": "24246119", "label": "conclusions", "text": "This study showed the biological and clinical benefit of a pharmalogical intervention .", "sentence_id": 6}
+{"abstract_id": "24246119", "label": "conclusions", "text": "Registration number of the study : ID RCB @-A@-@ .", "sentence_id": 7}
+{"abstract_id": "25241957", "label": "background", "text": "Knot tying is a fundamental and crucial surgical skill .", "sentence_id": 0}
+{"abstract_id": "25241957", "label": "background", "text": "We developed a kinesthetic pedagogical approach that increases precision and economy of motion by explicitly teaching suture-handling maneuvers and studied its effects on novice performance .", "sentence_id": 1}
+{"abstract_id": "25241957", "label": "methods", "text": "Seventy-four first-year medical students were randomized to learn knot tying via either the traditional or the novel `` kinesthetic '' method .", "sentence_id": 2}
+{"abstract_id": "25241957", "label": "methods", "text": "After @ week of independent practice , students were videotaped performing @ tying tasks .", "sentence_id": 3}
+{"abstract_id": "25241957", "label": "methods", "text": "Three raters scored deidentified videos using a validated visual analog scale .", "sentence_id": 4}
+{"abstract_id": "25241957", "label": "methods", "text": "The groups were compared using analysis of covariance with practice knots as a covariate and visual analog scale score ( range , @ to @ ) as the dependent variable .", "sentence_id": 5}
+{"abstract_id": "25241957", "label": "methods", "text": "Partial eta-square was calculated to indicate effect size .", "sentence_id": 6}
+{"abstract_id": "25241957", "label": "results", "text": "Overall rater reliability was @ .", "sentence_id": 7}
+{"abstract_id": "25241957", "label": "results", "text": "The kinesthetic group scored significantly higher than the traditional group for individual tasks and overall , controlling for practice ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25241957", "label": "results", "text": "The kinesthetic overall mean was @ ( standard deviation = @ ) vs traditional @ ( standard deviation = @ ; P < @ ; effect size = @ ) .", "sentence_id": 9}
+{"abstract_id": "25241957", "label": "conclusions", "text": "For novices , emphasizing kinesthetic suture handling substantively improved performance on knot tying .", "sentence_id": 10}
+{"abstract_id": "25241957", "label": "conclusions", "text": "We believe this effect can be extrapolated to more complex surgical skills .", "sentence_id": 11}
+{"abstract_id": "25794092", "label": "objective", "text": "The purpose of this study was to determine whether the occurrence of numerous colonic bubbles during CT colonography ( CTC ) performed with polyethylene glycol cleansing and oral iohexol fecal/fluid tagging could be prevented by use of simethicone .", "sentence_id": 0}
+{"abstract_id": "25794092", "label": "methods", "text": "Adults with suspected colonic neoplasia who had been randomly assigned to control and simethicone intervention groups underwent CTC after cleansing with @ L of polyethylene glycol , tagging with @ mL of @ mg I/mL oral iohexol , and without ( control ) or with ( intervention ) oral administration of @ mg of simethicone .", "sentence_id": 1}
+{"abstract_id": "25794092", "label": "methods", "text": "Colonic segments in the control and intervention groups were evaluated for amount of colonic bubbles during CTC .", "sentence_id": 2}
+{"abstract_id": "25794092", "label": "methods", "text": "A @-point grading system was used in which @ indicated no bubbles and @ indicated that more than three fourths of the air-distended mucosa was covered with bubbles .", "sentence_id": 3}
+{"abstract_id": "25794092", "label": "methods", "text": "The primary endpoint was a per-patient colonic bubble grade , derived as an average of the segmental grades .", "sentence_id": 4}
+{"abstract_id": "25794092", "label": "results", "text": "Eighty adults with suspected colonic neoplasia were randomly assigned to the control ( @ patients ) and simethicone intervention ( @ patients ) groups .", "sentence_id": 5}
+{"abstract_id": "25794092", "label": "results", "text": "A total of @ colonic segments in the control group and @ segments in the intervention group were evaluated for amount of colonic bubbles during CTC .", "sentence_id": 6}
+{"abstract_id": "25794092", "label": "results", "text": "The per-patient colonic bubble score was significantly lower in the simethicone intervention group than in the control group .", "sentence_id": 7}
+{"abstract_id": "25794092", "label": "results", "text": "The mean score was @ ( SD ) versus @ ( p < @ ; @ % CI for the mean difference , -@ to -@ ) .", "sentence_id": 8}
+{"abstract_id": "25794092", "label": "results", "text": "In the intervention group , @ ( @ % ) segments were grade @ , and @ ( @ % ) were grade @ .", "sentence_id": 9}
+{"abstract_id": "25794092", "label": "results", "text": "In contrast , in the control group , @ ( @ % ) segments were grade @ ; @ ( @ % ) , grade @ ; @ ( @ % ) , grade @ ; @ ( @ % ) , grade @ ; @ ( @ % ) , grade @ ; and @ ( @ % ) , grade @ .", "sentence_id": 10}
+{"abstract_id": "25794092", "label": "conclusions", "text": "The colonic bubbles associated with fecal/fluid tagging with iohexol can be successfully prevented by adding simethicone to the colonic preparation .", "sentence_id": 11}
+{"abstract_id": "25233645", "label": "objective", "text": "To compare the difference in clinical efficacy on post-stroke sensory disturbance between catgut implantation at scalp reflecting foci and conventional acupuncture as well as the impacts on blood rheology .", "sentence_id": 0}
+{"abstract_id": "25233645", "label": "methods", "text": "Fifty-nine cases of post-stroke sensory disturbance were randomized into a catgut implantation group ( @ cases ) and an acupuncture group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "25233645", "label": "methods", "text": "The conventional internal medicine treatment , limb motor function rehabilitation training and sensory function training were applied in the two groups .", "sentence_id": 2}
+{"abstract_id": "25233645", "label": "methods", "text": "Additionally , the catgut implantation was used at scalp reflecting foci in the catgut implantation group , once a week , @ treatment made one session .", "sentence_id": 3}
+{"abstract_id": "25233645", "label": "methods", "text": "In the acupuncture group , acupuncture was applied at Baihui ( GV @ ) , Fengchi ( GB @ ) , Jianyu ( LI @ ) , Quchi ( LI @ ) , Waiguan ( TE @ ) , Hegu ( LI @ ) , Siqiang ( EX-LE @ ) , Yanglingquan ( GB @ ) , Zusanli ( ST @ ) , Fenglong ( ST @ ) , Qiuxu ( GB @ ) and Taichong ( LR @ ) , once every day , @ times a week , the @ weeks of treatment made one session .", "sentence_id": 4}
+{"abstract_id": "25233645", "label": "methods", "text": "There was an interval of @ week between the two sessions in the two groups .", "sentence_id": 5}
+{"abstract_id": "25233645", "label": "methods", "text": "Totally , @ sessions of treatment were required .", "sentence_id": 6}
+{"abstract_id": "25233645", "label": "methods", "text": "Before and after treatment , the sensory and motor scores , modified barthel index ( MBI ) and blood rheological indices were observed , and the clinical efficacy was evaluated in the patients of the two groups .", "sentence_id": 7}
+{"abstract_id": "25233645", "label": "results", "text": "After @ weeks of treatment , the total effective rate was @ % ( @/@ ) in the catgut implantation group , which was better than @ % ( @/@ ) in the acupuncture group ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25233645", "label": "results", "text": "FugI-Meyer motor function , sensory function scores and MBI were all improved as compared with those before treat ment in the two groups ( all P < @ ) , and the results in the catgut implantation group was superior to the acu puncture group ( all P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25233645", "label": "results", "text": "The levels of whole blood viscosity , erythrocyte hematocrit , platelet aggregation and fibrinogen were improved as compared with those before treatment ( all P < @ ) , and the results in the catgut implantation group was better than those in the acupuncture group ( all P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25233645", "label": "conclusions", "text": "The catgut implantation at scalp reflecting foci achieves a satisfactory clinical efficacy on post-stroke sensory disturbance and improves the blood rheological indices .", "sentence_id": 11}
+{"abstract_id": "25433674", "label": "background", "text": "Adherence to the Heart Failure Society of America ( HFSA ) @ guidelines recommending @ minutes of supervised moderate intensity exercise five days per week is difficult for patients with heart failure ( HF ) .", "sentence_id": 0}
+{"abstract_id": "25433674", "label": "background", "text": "Innovative programs are needed to assist HF patients to adhere to long-term exercise .", "sentence_id": 1}
+{"abstract_id": "25433674", "label": "background", "text": "The objective of this prospective randomized two-group repeated measures experimental design is to determine the efficacy of a behavioral exercise training intervention on long-term adherence to exercise at @ months in patients with heart failure .", "sentence_id": 2}
+{"abstract_id": "25433674", "label": "methods", "text": "A sample size of @ subjects with heart failure will be recruited over a @ year period .", "sentence_id": 3}
+{"abstract_id": "25433674", "label": "methods", "text": "All subjects receive a cardiopulmonary exercise test and @ supervised exercise training sessions during a @ week run-in period prior to randomization .", "sentence_id": 4}
+{"abstract_id": "25433674", "label": "methods", "text": "Subjects completing at least @ of @ training sessions are randomized to the HEART Camp Intervention group ( HC ) or to a standard care ( SC ) exercise group .", "sentence_id": 5}
+{"abstract_id": "25433674", "label": "methods", "text": "The HC intervention group receives cognitive-behavioral strategies that address the intervention components of knowledge , attitudes , self-efficacy , behavioral self-management skills and social support .", "sentence_id": 6}
+{"abstract_id": "25433674", "label": "methods", "text": "The SC group is provided access to the exercise facility and regular facility staff for the @ month study period .", "sentence_id": 7}
+{"abstract_id": "25433674", "label": "methods", "text": "The primary aim is to evaluate the effect of HEART Camp on adherence to exercise , with our central hypothesis that the HC group will have significantly better adherence to exercise at @ months .", "sentence_id": 8}
+{"abstract_id": "25433674", "label": "methods", "text": "Secondary aims include evaluating which components of the HEART Camp intervention mediate the effects of the intervention on adherence ; evaluating the effect of HEART Camp on specific health outcomes ; exploring selected demographic variables ( race , gender , age ) as potential moderators of the effect of the HEART Camp intervention on adherence ; and exploring the perceptions and experiences that contextualize exercise adherence .", "sentence_id": 9}
+{"abstract_id": "25433674", "label": "conclusions", "text": "The HEART Camp intervention is the first to test a multi-component intervention designed to improve long-term adherence to exercise behavior in patients with HF .", "sentence_id": 10}
+{"abstract_id": "25433674", "label": "conclusions", "text": "Improving long-term adherence to exercise is the logical first step to ensure the required dose of exercise that is necessary to realize beneficial health outcomes and reduce costs in this burdensome chronic illness .", "sentence_id": 11}
+{"abstract_id": "25002101", "label": "background", "text": "Chronic gastritis ( CG ) , a poorly understood entity , is a very common disease of the digestive tract and is difficult to cure .", "sentence_id": 0}
+{"abstract_id": "25002101", "label": "background", "text": "Chronic non-atrophic gastritis ( CNG ) is the most common type of CG .", "sentence_id": 1}
+{"abstract_id": "25002101", "label": "background", "text": "Even if treated with current standard chemotherapy , some patients will not be freed from this confusing disease .", "sentence_id": 2}
+{"abstract_id": "25002101", "label": "background", "text": "Many studies have shown traditional Chinese medicine ( TCM ) is more effective compared to chemotherapy in the treatment of chronic gastritis and no serious side effects have been identified .", "sentence_id": 3}
+{"abstract_id": "25002101", "label": "background", "text": "However , the studies that have been carried out were not scientifically rigorous trials .", "sentence_id": 4}
+{"abstract_id": "25002101", "label": "background", "text": "Our aim is to design a high-quality trial for a new TCM drug , the Jian-Wei-Qu-Tong Pills ( JWQTP ) , to investigate the efficacy and safety of this new drug in treating chronic non-atrophic gastritis patients with spleen and stomach qi deficiency with damp-heat stasis syndrome ( SSQDDSS ) .", "sentence_id": 5}
+{"abstract_id": "25002101", "label": "methods", "text": "This is a phase II , multicenter , parallel-group , double-blind , randomized and placebo-controlled trial .", "sentence_id": 6}
+{"abstract_id": "25002101", "label": "methods", "text": "A total of @ participants will be assigned to a high-dose group , a low-dose group or a placebo control group with a @:@:@ ratio at five sites .", "sentence_id": 7}
+{"abstract_id": "25002101", "label": "methods", "text": "Then , one dose ( six @-g pills ) , with a variable ratio between real drug and dummy drug according to the intervention protocol , will be taken three times a day before each meal for @ weeks .", "sentence_id": 8}
+{"abstract_id": "25002101", "label": "methods", "text": "The primary outcome is the eradication rate of epigastric pain .", "sentence_id": 9}
+{"abstract_id": "25002101", "label": "methods", "text": "The secondary outcome includes the changes of endoscopic examination , histopathological examination , traditional Chinese medicine symptom scores and patient-reported outcome instrument scores for chronic gastrointestinal diseases and the eradication rate of Helicobacter pylori ( HP ) .", "sentence_id": 10}
+{"abstract_id": "25002101", "label": "conclusions", "text": "Many CNG patients suffer from frequent , recurrent bouts of dyspeptic symptoms .", "sentence_id": 11}
+{"abstract_id": "25002101", "label": "conclusions", "text": "This is the first clinical trial to evaluate the safety and efficacy of JWQTP in treating CNG with SSQDDSS in a multicenter , parallel-group , double-blind , randomized and placebo-controlled manner .", "sentence_id": 12}
+{"abstract_id": "25002101", "label": "conclusions", "text": "This trial may not only provide evidence for a phase III clinical trial , but also a vision of an alternative option for CNG treatment .", "sentence_id": 13}
+{"abstract_id": "24894533", "label": "objective", "text": "To compare the efficacy of tamsulosin versus tamsulosin plus tadalafil as medical expulsive therapy for lower ureteric stones .", "sentence_id": 0}
+{"abstract_id": "24894533", "label": "methods", "text": "Between January @ and December @ , @ patients presenting with distal ureteric stones ( size @-@mm ) were randomized equally to tamsulosin ( group A ) or tamsulosin plus tadalafil ( group B ) .", "sentence_id": 1}
+{"abstract_id": "24894533", "label": "methods", "text": "Therapy was given for a maximum of @ weeks .", "sentence_id": 2}
+{"abstract_id": "24894533", "label": "methods", "text": "Stone expulsion rate , time to stone expulsion , analgesic use , number of hospital visits for pain , follow up , endoscopic treatment and adverse effects of drugs were recorded .", "sentence_id": 3}
+{"abstract_id": "24894533", "label": "methods", "text": "Statistical analyses were carried out using Student 's t-test and the ( @ ) - test .", "sentence_id": 4}
+{"abstract_id": "24894533", "label": "results", "text": "There was a statistically significant higher expulsion rate in group B compared with group A ( @ % vs @ % ; P-value = @ ) and a shorter time to expulsion ( @ days vs @ days ; P-value = @ ) .", "sentence_id": 5}
+{"abstract_id": "24894533", "label": "results", "text": "Statistically significant differences were noted in terms of the number of hospital visits and analgesic requirement in favor of group B.", "sentence_id": 6}
+{"abstract_id": "24894533", "label": "results", "text": "There was no serious adverse event .", "sentence_id": 7}
+{"abstract_id": "24894533", "label": "results", "text": "An improvement in erectile function was noted in patients of group B compared with those of group A.", "sentence_id": 8}
+{"abstract_id": "24894533", "label": "conclusions", "text": "Medical expulsive therapy for distal ureteric stones using tamsulosin plus tadalafil is safe , effective and well tolerated .", "sentence_id": 9}
+{"abstract_id": "24894533", "label": "conclusions", "text": "Furthermore , tadalafil provides the additional advantage of improving erectile dysfunction when this condition coexists with a lower ureteric stone .", "sentence_id": 10}
+{"abstract_id": "25398398", "label": "objective", "text": "This prospective randomized study reports the effect of hyaluronan-enriched embryo transfer media on the outcome of in vitro fertilization and embryo transfer ( IVF-ET ) treatments .", "sentence_id": 0}
+{"abstract_id": "25398398", "label": "methods", "text": "A total of @ IVF-ET cycles were included in this study .", "sentence_id": 1}
+{"abstract_id": "25398398", "label": "methods", "text": "In the Hyaluronan ( HA ) group ( n = @ ) , embryos were transferred from hyaluronan-enriched transfer medium .", "sentence_id": 2}
+{"abstract_id": "25398398", "label": "methods", "text": "In Control group ( n = @ ) , a conventional embryo transfer medium was used .", "sentence_id": 3}
+{"abstract_id": "25398398", "label": "results", "text": "There was no significant difference in clinical pregnancy rate ( @ vs. @ % ) , implantation rate ( @ vs. @ % ) , and delivery rate ( @ vs. @ % ) between the HA group and the Control group .", "sentence_id": 4}
+{"abstract_id": "25398398", "label": "results", "text": "The number of newborns was also similar in the two groups ( @ vs. @ ) .", "sentence_id": 5}
+{"abstract_id": "25398398", "label": "results", "text": "However , birth weight was significantly higher in the HA group than in the Control group ( @,@ @ g vs. @,@ @ g , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25398398", "label": "results", "text": "Clinical pregnancy , implantation and delivery rates did not differ significantly between the HA and the Control group when cycles with advanced maternal age , previous IVF failures , low oocyte number or poor embryo quality were compared .", "sentence_id": 7}
+{"abstract_id": "25398398", "label": "conclusions", "text": "Our results suggest that hyaluronan enrichment of the embryo transfer media does not seem to have any beneficial effect on IVF outcome .", "sentence_id": 8}
+{"abstract_id": "25398398", "label": "conclusions", "text": "However , further study is needed to clarify the role of hyaluronan in the implantation process and on the birth weight .", "sentence_id": 9}
+{"abstract_id": "25149596", "label": "objective", "text": "Ipragliflozin is a novel and highly selective sodium-glucose transporter @ ( SGLT@ ) inhibitor that reduces plasma glucose levels by enhancing urinary glucose excretion in patients with type @ diabetes mellitus ( T@DM ) .", "sentence_id": 0}
+{"abstract_id": "25149596", "label": "objective", "text": "We examined the pharmacokinetic and pharmacodynamic characteristics of two oral doses of ipragliflozin in Japanese patients with T@DM .", "sentence_id": 1}
+{"abstract_id": "25149596", "label": "methods", "text": "In this randomized , placebo-controlled , double-blind study , patients were treated with placebo , @mg or @mg ipragliflozin once daily for @ days .", "sentence_id": 2}
+{"abstract_id": "25149596", "label": "methods", "text": "Plasma and urine pharmacodynamic parameters were measured on Days -@ and @ , and pharmacokinetic parameters on Day @ .", "sentence_id": 3}
+{"abstract_id": "25149596", "label": "methods", "text": "Pharmacodynamic characteristics included area under the curve ( AUC ) for plasma glucose and insulin for @-@h ( AUC@-@h ) and @-@h ( AUC@-@h ) .", "sentence_id": 4}
+{"abstract_id": "25149596", "label": "methods", "text": "Pharmacokinetic characteristics included AUC@-@h , maximum ipragliflozin concentration ( Cmax ) , and time to maximum plasma ipragliflozin concentration ( tmax ) .", "sentence_id": 5}
+{"abstract_id": "25149596", "label": "results", "text": "Thirty patients were enrolled ; @ were included in pharmacokinetic/pharmacodynamic analyses and @ in safety analyses .", "sentence_id": 6}
+{"abstract_id": "25149596", "label": "results", "text": "Administration of @ and @mg ipragliflozin significantly reduced fasting plasma glucose , as well as the AUC@-@h and AUC@-@h for plasma glucose relative to placebo .", "sentence_id": 7}
+{"abstract_id": "25149596", "label": "results", "text": "Both doses of ipragliflozin also reduced AUC@-@h for insulin , body weight , and glycoalbumin , while urinary glucose excretion increased remarkably .", "sentence_id": 8}
+{"abstract_id": "25149596", "label": "results", "text": "Cmax and AUC@-@h were @ - and @-fold higher , respectively , in the @-mg group than in the @-mg group .", "sentence_id": 9}
+{"abstract_id": "25149596", "label": "conclusions", "text": "Ipragliflozin increased urinary glucose excretion and improved fasting and postprandial glucose , confirming its pharmacokinetic/pharmacodynamic properties in Japanese patients with T@DM .", "sentence_id": 10}
+{"abstract_id": "24266074", "label": "objective", "text": "To observe the outcome after sacral canal injection in patients with disc herniation associated with without sciatica .", "sentence_id": 0}
+{"abstract_id": "24266074", "label": "methods", "text": "From December @ to June @ , @ patients with acute low back pain without sciatica due to lumbar disc herniation or bulging confirmed by CT or MRI were randomly divided into sacral canal injection group ( experimental group ) and lumbar oblique wrench group ( control group ) : the experimental group had @ cases , including @ males and @ females , with an average age of ( @ + / - @ ) years old ranging from @ to @ years old .", "sentence_id": 1}
+{"abstract_id": "24266074", "label": "methods", "text": "The control group had @ cases , including @ males and @ females , with an average age of ( @ + / - @ ) years old ranging from @ to @ years old .", "sentence_id": 2}
+{"abstract_id": "24266074", "label": "methods", "text": "The course of morbidity was @ to @ days .", "sentence_id": 3}
+{"abstract_id": "24266074", "label": "methods", "text": "All patients received sacral canal injection or lumbar oblique wrench method .", "sentence_id": 4}
+{"abstract_id": "24266074", "label": "methods", "text": "The visual analog scale ( VAS ) scores before and at @ min after treatment were compared between two groups .", "sentence_id": 5}
+{"abstract_id": "24266074", "label": "results", "text": "The symptom of acute low back pain were relieved obviously .", "sentence_id": 6}
+{"abstract_id": "24266074", "label": "results", "text": "The average VAS scores before and after treatment in experimental group were decreased from @ + / - @ to @ + / - @ , in control group were from @ + / - @ to @ + / - @ respectively .", "sentence_id": 7}
+{"abstract_id": "24266074", "label": "results", "text": "These two methods could improve the VAS score , but the effect of sacral canal injection group was better than that of lumbar oblique wrench group , there was statistically differences ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24266074", "label": "conclusions", "text": "It is effective that the methods of sacral canal injection and lumbar oblique wrench applied to patients with acute low back pain without sciatica due to lumbar disc herniation or bulging confirmed , the former has better effect .", "sentence_id": 9}
+{"abstract_id": "24983748", "label": "objective", "text": "Weight loss reduces risk factors associated with obesity .", "sentence_id": 0}
+{"abstract_id": "24983748", "label": "objective", "text": "However , long-term metabolic improvement remains a challenge .", "sentence_id": 1}
+{"abstract_id": "24983748", "label": "objective", "text": "We investigated quantitative gene expression of subcutaneous adipose tissue in obese individuals and its relationship with low calorie diet and long term weight maintenance induced changes in insulin resistance .", "sentence_id": 2}
+{"abstract_id": "24983748", "label": "methods", "text": "Three hundred eleven overweight and obese individuals followed a dietary protocol consisting of an @-week low calorie diet followed by a @-month ad libitum weight-maintenance diet .", "sentence_id": 3}
+{"abstract_id": "24983748", "label": "methods", "text": "Individuals were clustered according to insulin resistance trajectories assessed using homeostasis model assessment of insulin resistance ( HOMA-IR ) index .", "sentence_id": 4}
+{"abstract_id": "24983748", "label": "methods", "text": "Adipose tissue mRNA levels of @ genes selected for regulation according to obesity , metabolic status and response to dieting was assessed using high throughput RT-qPCR .", "sentence_id": 5}
+{"abstract_id": "24983748", "label": "methods", "text": "A combination of discriminant analyses was used to identify genes with regulation according to insulin resistance trajectories .", "sentence_id": 6}
+{"abstract_id": "24983748", "label": "methods", "text": "Partial correlation was used to control for change in body mass index .", "sentence_id": 7}
+{"abstract_id": "24983748", "label": "results", "text": "Three different HOMA-IR profile groups were determined .", "sentence_id": 8}
+{"abstract_id": "24983748", "label": "results", "text": "HOMA-IR improved during low calorie diet in the @ groups .", "sentence_id": 9}
+{"abstract_id": "24983748", "label": "results", "text": "At the end of the @-month follow-up , groups A and B had reduced HOMA-IR by @ % .", "sentence_id": 10}
+{"abstract_id": "24983748", "label": "results", "text": "In group C , HOMA-IR had returned to baseline values .", "sentence_id": 11}
+{"abstract_id": "24983748", "label": "results", "text": "Genes were differentially expressed in the adipose tissue of individuals according to groups but a single gene , CIDEA , was common to all phases of the dietary intervention .", "sentence_id": 12}
+{"abstract_id": "24983748", "label": "results", "text": "Changes in adipose tissue CIDEA mRNA levels paralleled variations in insulin sensitivity independently of change in body mass index .", "sentence_id": 13}
+{"abstract_id": "24983748", "label": "results", "text": "Overall , CIDEA was up-regulated in adipose tissue of individuals with successful long term insulin resistance relapse and not in adipose tissue of unsuccessful individuals .", "sentence_id": 14}
+{"abstract_id": "24983748", "label": "conclusions", "text": "The concomitant change in adipose tissue CIDEA mRNA levels and insulin sensitivity suggests a beneficial role of adipose tissue CIDEA in long term glucose homeostasis , independently of weight variation .", "sentence_id": 15}
+{"abstract_id": "24709364", "label": "background", "text": "Despite the increasing complexity of medication regimens for persistent cancer pain , little is known about how oncology outpatients and their family caregivers manage pain medications at home .", "sentence_id": 0}
+{"abstract_id": "24709364", "label": "objective", "text": "To describe the day-to-day management of pain medications from the perspectives of oncology outpatients and their family caregivers who participated in a randomized clinical trial of a psychoeducational intervention called the Pro-Self ( ) Plus Pain Control Program .", "sentence_id": 1}
+{"abstract_id": "24709364", "label": "objective", "text": "In this article , we focus on pain medication management in the context of highly individualized home environments and lifestyles .", "sentence_id": 2}
+{"abstract_id": "24709364", "label": "methods", "text": "This qualitative study was conducted as part of a randomized clinical trial , in which an embedded mixed methods research design was used .", "sentence_id": 3}
+{"abstract_id": "24709364", "label": "methods", "text": "Audio-recorded dialogue among patients , family caregivers , and intervention nurses was analyzed using qualitative research methods .", "sentence_id": 4}
+{"abstract_id": "24709364", "label": "results", "text": "Home and lifestyle contexts for managing pain medications included highly individualized home environments , work and recreational activities , personal routines , and family characteristics .", "sentence_id": 5}
+{"abstract_id": "24709364", "label": "results", "text": "Pain medication management processes particularly relevant in these contexts included understanding , organizing , storing , scheduling , remembering , and taking the medications .", "sentence_id": 6}
+{"abstract_id": "24709364", "label": "results", "text": "With the exception of their interactions with the intervention nurses , most study participants had little involvement with clinicians as they worked through these processes .", "sentence_id": 7}
+{"abstract_id": "24709364", "label": "conclusions", "text": "Pain medication management is an ongoing multidimensional process , each step of which has to be mastered by patients and their family caregivers when cancer treatment and supportive care are provided on an outpatient basis .", "sentence_id": 8}
+{"abstract_id": "24709364", "label": "conclusions", "text": "Realistic patient - and family-centered skill-building interventions are needed to achieve effective and safe pain medication management in the contexts of individual home environments and lifestyles .", "sentence_id": 9}
+{"abstract_id": "24861276", "label": "objective", "text": "To assess the comparative drug systemic exposure of a reference ( RF ) and four test ( Test I , Test II , Test III and Test IV ) formulations of triclabendazole ( TCBZ ) in heifers .", "sentence_id": 0}
+{"abstract_id": "24861276", "label": "methods", "text": "Thirty Holstein heifers were randomly distributed into five groups ( n = @ per group ) .", "sentence_id": 1}
+{"abstract_id": "24861276", "label": "methods", "text": "Animals in the RF group received the reference formulation ( Fasinex ) , and those in the other groups received different commercially available TCBZ formulations ( Test I , Test II , Test III and Test IV ) .", "sentence_id": 2}
+{"abstract_id": "24861276", "label": "methods", "text": "All treatments were orally administered at @ mg/kg bodyweight .", "sentence_id": 3}
+{"abstract_id": "24861276", "label": "methods", "text": "The concentrations of TCBZ metabolites in plasma between @ and @ hours after treatment were quantified by high-performance liquid chromatography ( HPLC ) .", "sentence_id": 4}
+{"abstract_id": "24861276", "label": "results", "text": "Triclabendazole sulphoxide ( TCBZ.SO ) and TCBZ-sulphone ( TCBZ.SO ) were the only analytes recovered in plasma .", "sentence_id": 5}
+{"abstract_id": "24861276", "label": "results", "text": "Only the Test I formulation did not differ from the RF for all pharmacokinetic parameters measured for either metabolite ( p > @ ) .", "sentence_id": 6}
+{"abstract_id": "24861276", "label": "results", "text": "The TCBZ.SO area under the concentration vs. time curve for Test II formulation ( @ g.h / mL ) was lower , and for Test III ( @ g.h / mL ) and Test IV ( @ g.h / mL ) was higher , than the RF ( @ g.h / mL ) ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24861276", "label": "conclusions", "text": "Based on the currently available bioequivalence criteria , the only test formulation under evaluation that could be considered equivalent to the RF was the Test I formulation , which demonstrated an equivalent systemic exposure for the active TCBZ.SO metabolite .", "sentence_id": 8}
+{"abstract_id": "24861276", "label": "conclusions", "text": "This comparison of TCBZ pioneer and test formulations in cattle raises awareness of the need for further quality control for drug approval in the veterinary pharmaceutical field in many regions of the world .", "sentence_id": 9}
+{"abstract_id": "24359036", "label": "objective", "text": "The purpose of this pilot study was to conduct limited-efficacy testing of the newly developed Preserving Identity and Planning for Advance Care ( PIPAC ) intervention on self-reported and proxy-reported emotional and health-related outcomes of individuals in the early stages of dementia .", "sentence_id": 0}
+{"abstract_id": "24359036", "label": "methods", "text": "A two-group comparison design was implemented .", "sentence_id": 1}
+{"abstract_id": "24359036", "label": "methods", "text": "Blocked randomization was used to assign individuals with mild dementia and a family contact to either ( @ ) the four-session , multi-component intervention group focused on reminiscence and future planning or ( @ ) the minimal support phone contact comparison group .", "sentence_id": 2}
+{"abstract_id": "24359036", "label": "methods", "text": "Of the @ enrolled dyads , @completed post-treatment assessments ( i.e. @ intervention and @ comparison group ) .", "sentence_id": 3}
+{"abstract_id": "24359036", "label": "methods", "text": "Individuals with dementia were M = @ ( SD = @ ) years old ; @ % were men and @ % were women .", "sentence_id": 4}
+{"abstract_id": "24359036", "label": "methods", "text": "Participants were predominantly white/Caucasian ( n = @ , @ % ) with one black/African-American ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "24359036", "label": "results", "text": "Analyses of covariance controlling for baseline differences revealed clinically meaningful differences ( with medium to large effect sizes ) between groups at post-treatment for depressive symptoms , quality of life , health-related quality of life indicators , and decisional conflict .", "sentence_id": 6}
+{"abstract_id": "24359036", "label": "results", "text": "Individuals in the intervention group were also observed to exhibit higher levels of coping .", "sentence_id": 7}
+{"abstract_id": "24359036", "label": "results", "text": "Feasibility data collected from participants and interventionists were encouraging .", "sentence_id": 8}
+{"abstract_id": "24359036", "label": "conclusions", "text": "Emotion-focused , patient-centered interventions like PIPAC hold promise for advancing treatment options in the early and mild stages of dementia .", "sentence_id": 9}
+{"abstract_id": "24359036", "label": "conclusions", "text": "A full-scale , randomized clinical trial of this intervention is warranted to determine both short-term and long-term impacts on clinical outcomes including improved depressive symptomatology , quality of life , and health-related factors that impact daily functioning in social environments .", "sentence_id": 10}
+{"abstract_id": "24935294", "label": "background", "text": "Currently , there are no published data on pharmacokinetics ( PK ) of everolimus in combination with cyclosporine in Japanese renal transplant patients .", "sentence_id": 0}
+{"abstract_id": "24935294", "label": "background", "text": "We evaluated the PK of everolimus in Japanese de novo renal transplant patients who received everolimus in combination with cyclosporine .", "sentence_id": 1}
+{"abstract_id": "24935294", "label": "methods", "text": "In this phase @ , multicenter , randomized , open-label study , patients were randomized ( @:@ ) to @ of the @ groups : everolimus @ mg ( targeted C@ of @-@ ng/mL ) plus reduced-dose cyclosporine or mycophenolate mofetil @ g/d plus standard-dose cyclosporine .", "sentence_id": 2}
+{"abstract_id": "24935294", "label": "methods", "text": "PK assessments for everolimus were performed on day @ ( month @ ) in the PK subpopulation .", "sentence_id": 3}
+{"abstract_id": "24935294", "label": "results", "text": "A total of @ patients ( @ men ) , mean age @ @ years , were enrolled for PK analysis of everolimus .", "sentence_id": 4}
+{"abstract_id": "24935294", "label": "results", "text": "Starting at @ mg ( @ mg twice a day ) , the mean dose over a period of @ days was @ @ mg .", "sentence_id": 5}
+{"abstract_id": "24935294", "label": "results", "text": "Everolimus mean trough concentration was @ @ ng/mL and mean peak concentration was @ @ ng/mL , which peaked at @ to @ hours postdose .", "sentence_id": 6}
+{"abstract_id": "24935294", "label": "results", "text": "The average concentration was @ @ ng/mL , area under the concentration-time curve was @ @ ngh/mL , and peak-trough fluctuation was @ % .", "sentence_id": 7}
+{"abstract_id": "24935294", "label": "results", "text": "The PK parameters of everolimus were comparable to those in the earlier phase @ studies ( A@ and A@ ) .", "sentence_id": 8}
+{"abstract_id": "24935294", "label": "results", "text": "The mean everolimus trough levels were within the target ranges at all time points ranging from @ to @ ng/mL ( everolimus @ mg twice a day , safety population ) .", "sentence_id": 9}
+{"abstract_id": "24935294", "label": "results", "text": "The majority of patients ( > @ % from day @ onward ) were maintained within the targeted everolimus trough blood levels ( safety population ) .", "sentence_id": 10}
+{"abstract_id": "24935294", "label": "results", "text": "These data were similar to a non-Japanese study ( A@ ) .", "sentence_id": 11}
+{"abstract_id": "24935294", "label": "conclusions", "text": "The pharmacokinetic characteristics of everolimus in Japanese de novo renal transplant patients did not differ from those previously observed in non-Japanese patients , hence the same dosage of everolimus may be acceptable in Japanese patients .", "sentence_id": 12}
+{"abstract_id": "25521275", "label": "background", "text": "Nerve growth factor ( NGF ) induces profound hyperalgesia .", "sentence_id": 0}
+{"abstract_id": "25521275", "label": "background", "text": "In this study we explored patterns of NGF sensitization in muscle and fascia of distal and paraspinal sites .", "sentence_id": 1}
+{"abstract_id": "25521275", "label": "methods", "text": "We injected @ g of NGF into human ( n = @ ) tibialis anterior and erector spinae muscles and their fasciae .", "sentence_id": 2}
+{"abstract_id": "25521275", "label": "methods", "text": "The spatial extent of pressure sensitization , pressure pain threshold , and mechanical hyperalgesia ( @ kPa , @ s ) was assessed at days @ , @ , @ , @ , @ , and @ .", "sentence_id": 3}
+{"abstract_id": "25521275", "label": "methods", "text": "Chemical sensitization was explored by acidic buffer injections ( pH @ , @ l ) at days @ and @ .", "sentence_id": 4}
+{"abstract_id": "25521275", "label": "results", "text": "The mechanical hyperalgesia area was larger in tibial fascia than in muscle .", "sentence_id": 5}
+{"abstract_id": "25521275", "label": "results", "text": "Pressure pain thresholds were lower , tonic pressure pain ratings , and citrate buffer evoked pain higher in fascia than in muscle .", "sentence_id": 6}
+{"abstract_id": "25521275", "label": "conclusions", "text": "Spatial mechanical sensitization differs between muscle and fascia .", "sentence_id": 7}
+{"abstract_id": "25521275", "label": "conclusions", "text": "Thoracolumbar fasciae appear more sensitive than tibial fasciae and may be major contributors to low back pain , but the temporal sensitization profile is similar between paraspinal and distal sites .", "sentence_id": 8}
+{"abstract_id": "25521275", "label": "conclusions", "text": "Muscle Nerve @ : @-@ , @ .", "sentence_id": 9}
+{"abstract_id": "24907224", "label": "background", "text": "Pegylated interferon ( peginterferon ) alfa @a or @b plus ribavirin regimens were the standard of care in patients with hepatitis C virus ( HCV ) infection , but the sustained virological response can be suboptimum in patients with HCV genotype @ infection .", "sentence_id": 0}
+{"abstract_id": "24907224", "label": "background", "text": "The efficacy , safety , and tolerability of the combination of simeprevir , a one-pill , once-daily , oral HCV NS@/@A protease inhibitor versus placebo , plus peginterferon alfa @a or @b plus ribavirin was assessed in treatment-naive patients with HCV genotype @ infection .", "sentence_id": 1}
+{"abstract_id": "24907224", "label": "methods", "text": "In the QUEST-@ , phase @ study , done at @ sites in @ countries ( Europe , and North and South Americas ) , patients with confirmed chronic HCV genotype @ infection and no history of HCV treatment were randomly assigned with a computer-generated allocation sequence in a ratio of @:@ and stratified by HCV genotype @ subtype and host IL@B genotype to receive simeprevir ( @ mg once daily , orally ) , peginterferon alfa @a ( @ g once weekly , subcutaneous injection ) or @b ( according to bodyweight ; @ g , @ g , @ g , @ g , or @ g once weekly , subcutaneous injection ) , plus ribavirin ( @-@ mg/day or @-@ mg/day , orally ; simeprevir group ) or placebo ( once daily , orally ) , peginterferon alfa @a or @b , plus ribavirin ( placebo group ) for @ weeks , followed by just peginterferon alfa @a or @b plus ribavirin .", "sentence_id": 2}
+{"abstract_id": "24907224", "label": "methods", "text": "Total treatment duration was @ weeks or @ weeks ( simeprevir group ) based on criteria for response-guided therapy ( ie , HCV RNA < @ IU/mL undetectable or detectable at week @ and undetectable week @ ) or @ weeks ( placebo ) .", "sentence_id": 3}
+{"abstract_id": "24907224", "label": "methods", "text": "Patients , study personnel , and the sponsor were masked to treatment assignment .", "sentence_id": 4}
+{"abstract_id": "24907224", "label": "methods", "text": "The primary efficacy endpoint was sustained virological response at @ weeks after the planned end of treatment ( SVR@ ) .", "sentence_id": 5}
+{"abstract_id": "24907224", "label": "methods", "text": "Analyses were by intention to treat .", "sentence_id": 6}
+{"abstract_id": "24907224", "label": "methods", "text": "The trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "24907224", "label": "methods", "text": "Results from the primary ( SVR@ , week @ ) analysis are presented .", "sentence_id": 8}
+{"abstract_id": "24907224", "label": "results", "text": "@ ( @ % ) of @ patients in the simeprevir group and @ ( @ % ) of @ in the placebo group had SVR@ ( adjusted difference @ % , @ % CI @-@ ; p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24907224", "label": "results", "text": "The incidences of adverse events were similar in the simeprevir and placebo groups at @ weeks ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) and for the entire treatment ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , irrespective of the peginterferon alfa used .", "sentence_id": 10}
+{"abstract_id": "24907224", "label": "results", "text": "The most common adverse events were headache , fatigue , pyrexia , and influenza-like illness at @ weeks ( @ -LSB- @ % ) vs @ -LSB- @ % -RSB- , @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , and @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , respectively ) and for the entire treatment ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , and @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , respectively ) .", "sentence_id": 11}
+{"abstract_id": "24907224", "label": "results", "text": "Rash and photosensitivity frequencies were higher in the simeprevir group than in the placebo group ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- and ten -LSB- @ % -RSB- vs one -LSB- < @ % -RSB- , respectively ) .", "sentence_id": 12}
+{"abstract_id": "24907224", "label": "results", "text": "There was no difference in the prevalence of anaemia between the simeprevir and placebo groups ( @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , respectively , at @ weeks , and @ -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- , respectively , during the entire treatment ) .", "sentence_id": 13}
+{"abstract_id": "24907224", "label": "conclusions", "text": "Addition of simeprevir to either peginterferon alfa @a or peginterferon alfa @b plus ribavirin improved SVR in treatment-naive patients with HCV genotype @ infection , without worsening the known adverse events associated with peginterferon alfa plus ribavirin .", "sentence_id": 14}
+{"abstract_id": "25644342", "label": "background", "text": "Bread can contribute to the regulation of appetite .", "sentence_id": 0}
+{"abstract_id": "25644342", "label": "objective", "text": "The objective of this study was to investigate the appetite ratings and postprandial glucose , insulin , and gastrointestinal hormone responses related to hunger and satiety after the intake of a cereal-based bread .", "sentence_id": 1}
+{"abstract_id": "25644342", "label": "methods", "text": "A randomized , controlled crossover trial was conducted in @ healthy adults ( @ men and @ women ) aged @-@ y with body mass index of @-@ @ .", "sentence_id": 2}
+{"abstract_id": "25644342", "label": "methods", "text": "Each volunteer consumed the cereal-based bread and the control bread @ times , with a @-wk wash-out period , over a total of @ sessions .", "sentence_id": 3}
+{"abstract_id": "25644342", "label": "methods", "text": "The cereal-based bread contained a variety of cereal flours ( wheat , oat , and spelt ) and consisted of @ % dried fruits ( figs , apricots , raisins , and prunes ) .", "sentence_id": 4}
+{"abstract_id": "25644342", "label": "methods", "text": "It was also enriched with both fiber ( @ % from wheat cross-linked maltodextrins and pea ) and protein ( @-@ % from wheat gluten and hydrolyzed wheat proteins ) .", "sentence_id": 5}
+{"abstract_id": "25644342", "label": "methods", "text": "The control bread consisted of white bread with margarine and jam to control for energy density , fat , and sugar content .", "sentence_id": 6}
+{"abstract_id": "25644342", "label": "methods", "text": "We measured appetite ratings using standardized visual analogue scales and glucose , insulin , and gastrointestinal hormone responses over a postprandial time of @ h after the ingestion of each bread .", "sentence_id": 7}
+{"abstract_id": "25644342", "label": "methods", "text": "Linear mixed-effects models were used to compare the areas under the curve ( AUCs ) for different variables .", "sentence_id": 8}
+{"abstract_id": "25644342", "label": "results", "text": "Consuming the cereal-based bread decreased prospective consumption more than consumption of the control bread ( -@ @ m min and -@ @ m min , respectively ; P = @ ) and increased satiety more ( @ @ m min and @ @ m min , respectively ; P = @ ) , although subsequent ad libitum energy intake @ h later did not differ .", "sentence_id": 9}
+{"abstract_id": "25644342", "label": "results", "text": "Postprandial blood glucose , insulin , ghrelin , glucagon-like peptide @ and gastric inhibitory polypeptide AUCs were lower after the ingestion of the cereal-based bread , whereas the pancreatic polypeptide AUC was higher than with the control bread ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25644342", "label": "conclusions", "text": "Consumption of the cereal-based bread contributed to appetite control by reducing hunger and enhancing satiety .", "sentence_id": 11}
+{"abstract_id": "25644342", "label": "conclusions", "text": "In addition , consumption of this bread improved glycemic , insulinemic , and gastrointestinal hormone responses in healthy adults .", "sentence_id": 12}
+{"abstract_id": "25644342", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 13}
+{"abstract_id": "25378034", "label": "objective", "text": "The purpose was to assess the effectiveness of @ % oral glucose solution in reducing pain in preterm infants during intramuscular injection .", "sentence_id": 0}
+{"abstract_id": "25378034", "label": "methods", "text": "We conducted a prospective , randomized , controlled , unblinded trial to investigate the effect of glucose solution on the pain of intramuscular injection in preterm infants ( N = @ ) .", "sentence_id": 1}
+{"abstract_id": "25378034", "label": "results", "text": "Infants who received oral glucose had significantly lower pain scores ( p < @ ) , less crying time ( p < @ ) , higher oxygen saturation ( p < @ ) , and lower heart rate after compared with during the procedure ( p = @ ) .", "sentence_id": 2}
+{"abstract_id": "25378034", "label": "conclusions", "text": "Our results suggest that oral glucose , even if used in the lowest dose , may have a pain-relieving effect in preterm infants if administered pre-procedure .", "sentence_id": 3}
+{"abstract_id": "25468945", "label": "objective", "text": "There are limited data about the effects of sodium-glucose cotransporter @ inhibitors when used with insulin .", "sentence_id": 0}
+{"abstract_id": "25468945", "label": "objective", "text": "We report the efficacy and safety of canagliflozin in patients with type @ diabetes using insulin .", "sentence_id": 1}
+{"abstract_id": "25468945", "label": "methods", "text": "The CANagliflozin CardioVascular Assessment Study is a double-blind , placebo-controlled study that randomized participants to placebo , canagliflozin @ mg , or canagliflozin @ mg once daily , added to a range of therapies .", "sentence_id": 2}
+{"abstract_id": "25468945", "label": "methods", "text": "The primary end point of this substudy was the change in HbA@c from baseline at @ weeks among patients using insulin ; @-week effects were also examined .", "sentence_id": 3}
+{"abstract_id": "25468945", "label": "results", "text": "Individuals receiving insulin at baseline were randomized to receive placebo ( n = @ ) , canagliflozin @ mg ( n = @ ) , or canagliflozin @ mg ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25468945", "label": "results", "text": "These individuals were @ % male and had a median age of @ years , mean HbA@c of @ % ( @ mmol/mol ) , BMI of @ kg/m ( @ ) , estimated glomerular filtration rate of @ mL/min/@ @ m ( @ ) , fasting plasma glucose of @ mmol/L , and a median daily insulin dose of @ IU .", "sentence_id": 5}
+{"abstract_id": "25468945", "label": "results", "text": "Most individuals were using basal/bolus insulin .", "sentence_id": 6}
+{"abstract_id": "25468945", "label": "results", "text": "Reductions in HbA@c with canagliflozin @ and @ mg versus placebo were -@ % ( @ % CI -@ , -@ ; -@ mmol/mol -LSB- @ % CI -@ , -@ -RSB- ; P < @ ) and -@ % ( @ % CI -@ , -@ ; -@ mmol/mol -LSB- @ % CI -@ , -@ -RSB- ; P < @ ) at @ weeks and -@ % ( @ % CI -@ , -@ ; -@ mmol/mol -LSB- @ % CI -@ , -@ -RSB- ) and -@ % ( @ % CI -@ , -@ ; -@ mmol/mol -LSB- @ % CI -@ , -@ -RSB- ) at @ weeks .", "sentence_id": 7}
+{"abstract_id": "25468945", "label": "results", "text": "There were significant falls in fasting plasma glucose , body weight , and blood pressure at both time points and there was a greater incidence of hypoglycemia , genital mycotic infections , and hypovolemia with both canagliflozin doses .", "sentence_id": 8}
+{"abstract_id": "25468945", "label": "conclusions", "text": "Canagliflozin added to insulin therapy improved glycemic control and decreased body weight .", "sentence_id": 9}
+{"abstract_id": "25468945", "label": "conclusions", "text": "There was a greater frequency of several anticipated side effects , although few led to discontinuation of treatment .", "sentence_id": 10}
+{"abstract_id": "25083010", "label": "objective", "text": "To assess the short-term efficacy of a video-based cognitive behavioral therapy for insomnia ( CBT-I ) as compared to a professionally administered CBT-I and to a no-treatment group .", "sentence_id": 0}
+{"abstract_id": "25083010", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25083010", "label": "methods", "text": "Radio-oncology department of a public hospital affiliated with Universit Laval ( CHU de Qubec ) .", "sentence_id": 2}
+{"abstract_id": "25083010", "label": "methods", "text": "Two hundred forty-two women with breast cancer who had received radiation therapy in the past @ mo and who had insomnia symptoms or were using hypnotic medications were randomized to : ( @ ) professionally administered CBT-I ( PCBT-I ; n = @ ) ; ( @ ) video-based CBT-I ( VCBT-I ; n = @ ) ; and ( @ ) no treatment ( CTL ; n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25083010", "label": "methods", "text": "PCBT-I composed of six weekly , individual sessions of approximately @ min ; VCBT-I composed of a @-min animated video + six booklets .", "sentence_id": 4}
+{"abstract_id": "25083010", "label": "results", "text": "Insomnia Severity Index ( ISI ) total score and sleep parameters derived from a daily sleep diary and actigraphy , collected at pretreatment and posttreatment .", "sentence_id": 5}
+{"abstract_id": "25083010", "label": "results", "text": "PCBT-I and VCBT-I were associated with significantly greater sleep improvements , assessed subjectively , as compared to CTL .", "sentence_id": 6}
+{"abstract_id": "25083010", "label": "results", "text": "However , relative to VCBT-I , PCBT-I was associated with significantly greater improvements of insomnia severity , early morning awakenings , depression , fatigue , and dysfunctional beliefs about sleep .", "sentence_id": 7}
+{"abstract_id": "25083010", "label": "results", "text": "The remission rates of insomnia ( ISI < @ ) were significantly greater in PCBT-I as compared to VCBT-I ( @ % versus @ % , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25083010", "label": "conclusions", "text": "A self-administered cognitive behavioral therapy for insomnia ( CBT-I ) using a video format appears to be a valuable treatment option , but face-to-face sessions remain the optimal format for administering CBT-I efficaciously in patients with breast cancer .", "sentence_id": 9}
+{"abstract_id": "25083010", "label": "conclusions", "text": "Self-help interventions for insomnia may constitute an appropriate entry level as part of a stepped care model .", "sentence_id": 10}
+{"abstract_id": "25454968", "label": "objective", "text": "To explore the experience of breast cancer patients who either received acupuncture or were allocated to the control group .", "sentence_id": 0}
+{"abstract_id": "25454968", "label": "methods", "text": "Focus group/interviews nested within our multi-site randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25454968", "label": "methods", "text": "Participants were recruited from the standard care and experimental arm .", "sentence_id": 2}
+{"abstract_id": "25454968", "label": "methods", "text": "The interviews/focus groups were transcribed and analysed thematically .", "sentence_id": 3}
+{"abstract_id": "25454968", "label": "results", "text": "Of the @ eligible participants @ % ( n = @ ) contributed to the focus groups/interviews , across three study sites in the UK .", "sentence_id": 4}
+{"abstract_id": "25454968", "label": "results", "text": "Five common themes were identified , including : drivers to take part , the experience of receiving acupuncture , being allocated standard care ( control ) and reflections on taking part in the trial .", "sentence_id": 5}
+{"abstract_id": "25454968", "label": "results", "text": "The subgroup of control group participants ( n = @ ) reported disappointment on hearing their allocation , but recognised the value of their role to the study .", "sentence_id": 6}
+{"abstract_id": "25454968", "label": "conclusions", "text": "Recipients of acupuncture reported beneficial effects in managing fatigue and related symptoms .", "sentence_id": 7}
+{"abstract_id": "25454968", "label": "conclusions", "text": "The finding that control participants were disappointed warrants further investigation and consideration when designing interventional studies .", "sentence_id": 8}
+{"abstract_id": "24691140", "label": "objective", "text": "The aim of this study was to explore the impact of dynamic contrast-enhanced ( DCE ) computer tomography ( CT ) as a biomarker in metastatic renal cell carcinoma ( mRCC ) .", "sentence_id": 0}
+{"abstract_id": "24691140", "label": "methods", "text": "Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group and clear cell mRCC participating in an ongoing prospective randomized phase II trial comprising interleukin-@-based immunotherapy and bevacizumab were included in this preliminary analysis .", "sentence_id": 1}
+{"abstract_id": "24691140", "label": "methods", "text": "All patients had a follow-up time of at least @ years .", "sentence_id": 2}
+{"abstract_id": "24691140", "label": "methods", "text": "Interpretation of DCE-CT ( max slope method ) was performed blinded to treatment group .", "sentence_id": 3}
+{"abstract_id": "24691140", "label": "methods", "text": "The DCE-CT scans were performed at baseline , at weeks @ and @ , and thereafter every third month .", "sentence_id": 4}
+{"abstract_id": "24691140", "label": "methods", "text": "Blood flow ( BF ; mL/min/@ mL ) , peak enhancement ( Hounsfield units ) , time to peak ( seconds ) , and blood volume ( BV ; mL/@ g ) were calculated .", "sentence_id": 5}
+{"abstract_id": "24691140", "label": "methods", "text": "Parameters for DCE-CT were correlated with sum of diameters ( defined by Response Evaluation Criteria in Solid Tumors @ ) , progression-free survival ( PFS ) , and overall survival ( OS ) using Wilcoxon , Man-Whitney , Kaplan-Meier , and log rank statistics , as appropriate .", "sentence_id": 6}
+{"abstract_id": "24691140", "label": "results", "text": "Blood flow at baseline ranged from @ to @ mL/min/@ mL ( median , @ ; @th percentile , @ ; @th percentile , @ ) .", "sentence_id": 7}
+{"abstract_id": "24691140", "label": "results", "text": "Patients with high baseline BF ( using quartiles as cutoffs ) had significantly longer OS ( not reached vs @ months , P = @ ) and longer PFS ( not reached vs @ months , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24691140", "label": "results", "text": "Blood volume at baseline ranged from @ to @ mL/@ g tissue ( median , @ ) , and at week @ , from @ to @ mL/@ g ( median , @ ) .", "sentence_id": 9}
+{"abstract_id": "24691140", "label": "results", "text": "Relative changes in BV between baseline and week @ ranged from -@ % to +@ % ( median , -@ % ; @th percentile , -@ % ; @th percentile , +@ % ) and were significantly associated with OS using quartiles as cutoffs ( @ months vs not reached , P = @ ) and PFS using the median as cutoff ( @ months vs not reached , P = @ ) , with larger reductions associated with longer survival .", "sentence_id": 10}
+{"abstract_id": "24691140", "label": "results", "text": "Using medians as cutoffs , relative changes in both BF and BV between baseline and week @ were significantly associated with OS ( for both , @ months vs not reached , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24691140", "label": "conclusions", "text": "Dynamic contrast-enhanced CT is a potential biomarker in patients with mRCC .", "sentence_id": 12}
+{"abstract_id": "24691140", "label": "conclusions", "text": "High baseline BF and reductions in BF and BV during early treatment are associated with improved outcome .", "sentence_id": 13}
+{"abstract_id": "24691140", "label": "conclusions", "text": "Large-scale studies are required .", "sentence_id": 14}
+{"abstract_id": "24752284", "label": "objective", "text": "The aims of this study were to ( i ) evaluate the efficacy of phoneme discrimination training for hearing and cognitive abilities of adults aged @ to @ years with mild sensorineural hearing loss who were not users of hearing aids , and to ( ii ) determine participant compliance with a self-administered , computer-delivered , home - and game-based auditory training program .", "sentence_id": 0}
+{"abstract_id": "24752284", "label": "methods", "text": "This study was a randomized controlled trial with repeated measures and crossover design .", "sentence_id": 1}
+{"abstract_id": "24752284", "label": "methods", "text": "Participants were trained and tested over an @ - to @-week period .", "sentence_id": 2}
+{"abstract_id": "24752284", "label": "methods", "text": "One group ( Immediate Training ) trained during weeks @ and @ .", "sentence_id": 3}
+{"abstract_id": "24752284", "label": "methods", "text": "A second waitlist group ( Delayed Training ) did no training during weeks @ and @ , but then trained during weeks @ and @ .", "sentence_id": 4}
+{"abstract_id": "24752284", "label": "methods", "text": "On-task ( phoneme discrimination ) and transferable outcome measures ( speech perception , cognition , self-report of hearing disability ) for both groups were obtained during weeks @ , @ , and @ , and for the Delayed Training group only at week @ .", "sentence_id": 5}
+{"abstract_id": "24752284", "label": "results", "text": "Robust phoneme discrimination learning was found for both groups , with the largest improvements in threshold shown for those with the poorest initial thresholds .", "sentence_id": 6}
+{"abstract_id": "24752284", "label": "results", "text": "Between weeks @ and @ , the Immediate Training group showed moderate , significant improvements on self-report of hearing disability , divided attention , and working memory , specifically for conditions or situations that were more complex and therefore more challenging .", "sentence_id": 7}
+{"abstract_id": "24752284", "label": "results", "text": "Training did not result in consistent improvements in speech perception in noise .", "sentence_id": 8}
+{"abstract_id": "24752284", "label": "results", "text": "There was no evidence of any test-retest effects between weeks @ and @ for the Delayed Training group .", "sentence_id": 9}
+{"abstract_id": "24752284", "label": "results", "text": "Retention of benefit at @ weeks post-training was shown for phoneme discrimination , divided attention , working memory , and self-report of hearing disability .", "sentence_id": 10}
+{"abstract_id": "24752284", "label": "results", "text": "Improved divided attention and reduced self-reported hearing difficulties were highly correlated .", "sentence_id": 11}
+{"abstract_id": "24752284", "label": "conclusions", "text": "It was observed that phoneme discrimination training benefits some but not all people with mild hearing loss .", "sentence_id": 12}
+{"abstract_id": "24752284", "label": "conclusions", "text": "Evidence presented here , together with that of other studies that used different training stimuli , suggests that auditory training may facilitate cognitive skills that index executive function and the self-perception of hearing difficulty in challenging situations .", "sentence_id": 13}
+{"abstract_id": "24752284", "label": "conclusions", "text": "The development of cognitive skills may be more important than the development of sensory skills for improving communication and speech perception in everyday life .", "sentence_id": 14}
+{"abstract_id": "24752284", "label": "conclusions", "text": "However , improvements were modest .", "sentence_id": 15}
+{"abstract_id": "24752284", "label": "conclusions", "text": "Outcome measures need to be appropriately challenging to be sensitive to the effects of the relatively small amount of training performed .", "sentence_id": 16}
+{"abstract_id": "24612764", "label": "objective", "text": "Expiratory asynchrony during pressure support ventilation ( PSV ) has been recognized as a cause of patient discomfort , increased workload , and impaired weaning process .", "sentence_id": 0}
+{"abstract_id": "24612764", "label": "objective", "text": "We evaluated breathing pattern , patient comfort , and patient effort during PSV comparing @ flow termination criteria : fixed at @ % of peak inspiratory flow vs automatic , real-time , breath-by-breath adjustment within the range of @ % to @ % .", "sentence_id": 1}
+{"abstract_id": "24612764", "label": "methods", "text": "Randomized crossover clinical trial .", "sentence_id": 2}
+{"abstract_id": "24612764", "label": "methods", "text": "Sixteen awake patients , in the process of weaning , under PSV for more than @ hours were subjected to @ phases of PSV , each lasting @ hour and using @ of the @ aforementioned termination criteria .", "sentence_id": 3}
+{"abstract_id": "24612764", "label": "results", "text": "Effective pressure support during automatic adjustment ( AA ) was @ cm H@O vs @ cm H@O ( P = @ ) with the fixed termination criterion , and external positive end-expiratory pressure was @ vs @ ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24612764", "label": "results", "text": "The effective termination criterion was higher during AA ( @ % -LSB- @-@ -RSB- vs @ % -LSB- @-@ -RSB- ; P < @ ) , but without producing premature breath terminations .", "sentence_id": 5}
+{"abstract_id": "24612764", "label": "results", "text": "Pressure overshoots and alternative cycling-off were also decreased .", "sentence_id": 6}
+{"abstract_id": "24612764", "label": "results", "text": "Throughout the AA period , we observed a higher respiratory rate ( @ breaths/min vs @ breaths/min ; P < @ ) , lower tidal volume ( @ @ mL vs @ mL ; P < @ ) , and shorter inspiratory times ( @ seconds vs @ seconds ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24612764", "label": "results", "text": "Automatic adjustment was associated with lower airway occlusion pressure after @ second ( P@ @ ) ( @ cm H@O vs @ cm H@O ; P < @ ) , lower pressure-time product to trigger the ventilator , and lower subjective discomfort ( visual analog scale , @ vs @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24612764", "label": "conclusions", "text": "When compared with a fixed termination criterion , the use of a variable , real-time-adjusted termination criterion improved some indices of patient-ventilator synchrony , producing better breathing pattern , less discomfort , and slightly lower patient effort during PSV .", "sentence_id": 9}
+{"abstract_id": "25268968", "label": "background", "text": "Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment ( MCI ) .", "sentence_id": 0}
+{"abstract_id": "25268968", "label": "background", "text": "The MEMO + study is a randomized , controlled , single-blind trial designed to test the efficacy , specificity , and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI .", "sentence_id": 1}
+{"abstract_id": "25268968", "label": "methods", "text": "One hundred and sixty-two participants with MCI will be recruited .", "sentence_id": 2}
+{"abstract_id": "25268968", "label": "methods", "text": "They will be randomized into three groups : cognitive training , psychosocial intervention , and no-contact .", "sentence_id": 3}
+{"abstract_id": "25268968", "label": "methods", "text": "Each intervention will last for eight weeks ( one session per week ) and a booster training session will be provided three months after the end of the intervention .", "sentence_id": 4}
+{"abstract_id": "25268968", "label": "methods", "text": "Various proximal and distal outcomes will be measured at pre-intervention as well as at one week , three months , and six months post-training .", "sentence_id": 5}
+{"abstract_id": "25268968", "label": "methods", "text": "Proximal outcomes include memory and psychological health measures .", "sentence_id": 6}
+{"abstract_id": "25268968", "label": "methods", "text": "Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function .", "sentence_id": 7}
+{"abstract_id": "25268968", "label": "methods", "text": "Socio-demographic factors ( age , gender , and education ) , general cognition , personality traits , engagement in activities , and self-efficacy will be used as moderators .", "sentence_id": 8}
+{"abstract_id": "25268968", "label": "methods", "text": "Enrolment began in April @ and will be completed by December @ .", "sentence_id": 9}
+{"abstract_id": "25268968", "label": "conclusions", "text": "This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions .", "sentence_id": 10}
+{"abstract_id": "25581505", "label": "objective", "text": "To identify risk factors for early study termination and motivators for adherence to a long-term followup trial and to improve completeness of long-term studies .", "sentence_id": 0}
+{"abstract_id": "25581505", "label": "methods", "text": "Risk factors for early termination in @ included patients were identified through Cox regression analysis .", "sentence_id": 1}
+{"abstract_id": "25581505", "label": "methods", "text": "Patients completing the @-year followup filled in a questionnaire on possible motives for continued study participation .", "sentence_id": 2}
+{"abstract_id": "25581505", "label": "results", "text": "Risk factors for early termination were higher age ( hazard ratio -LSB- HR -RSB- @ , @ % confidence interval -LSB- @ % CI -RSB- @-@ @ ) , functional disability during the preceding year ( HR @ , @ % CI @-@ @ ) , having achieved drug-free remission ( HR @ , @ % CI @-@ @ ) , limited joint damage ( HR @ , @ % CI @-@ @ for actual damage ; HR @ , @ % CI @-@ @ for damage progression ) , and few adverse events ( HR @ , @ % CI @-@ @ ) .", "sentence_id": 3}
+{"abstract_id": "25581505", "label": "results", "text": "A total of @ of @ patients ( @ % ) attending the last visit answered the questionnaire .", "sentence_id": 4}
+{"abstract_id": "25581505", "label": "results", "text": "The majority mentioned contributing to scientific research ( @ % agreed ) , helping other patients ( @ % ) , and learning about new treatment strategies ( @ % ) and their disease ( @ % ) as reasons to continue participation .", "sentence_id": 5}
+{"abstract_id": "25581505", "label": "results", "text": "Next , patients mentioned tight control ( @ of @ patients ) , good treatment strategy ( @ of @ ) , good medication ( @ of @ ) , and good half-term results ( @ of @ ) as motivators .", "sentence_id": 6}
+{"abstract_id": "25581505", "label": "results", "text": "More than @ % of patients experienced participation `` as expected '' or `` better than expected . ''", "sentence_id": 7}
+{"abstract_id": "25581505", "label": "results", "text": "Additional examinations during yearly visits ( extra questionnaires , imaging ) were mentioned as `` worse than expected '' ( @ % ) , as was answering routine questionnaires ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "25581505", "label": "conclusions", "text": "Continued participation was relatively high in the Treatment Strategies for Rheumatoid Arthritis ( BeSt ) Study .", "sentence_id": 9}
+{"abstract_id": "25581505", "label": "conclusions", "text": "Higher age , functional disability , drug-free remission , little joint damage , and few adverse events predicted early study termination .", "sentence_id": 10}
+{"abstract_id": "25581505", "label": "conclusions", "text": "Main motives for continued participation were a willingness to contribute to research , help future patients , and because patients had good experiences with the study protocol .", "sentence_id": 11}
+{"abstract_id": "25320199", "label": "background", "text": "The surgical results of treating thoracolumbar and lumbar burst fractures were reported to be comparable between patients with and without fusion in an intermediate-term follow-up .", "sentence_id": 0}
+{"abstract_id": "25320199", "label": "background", "text": "To our knowledge , no prior report has compared the results of fusion and non-fusion with long-term follow-up .", "sentence_id": 1}
+{"abstract_id": "25320199", "label": "methods", "text": "This study was designed to provide long-term evaluation of patients with a burst fracture of the thoracolumbar and lumbar spine treated with short-segment fixation who were randomly assigned to a fusion or non-fusion group .", "sentence_id": 2}
+{"abstract_id": "25320199", "label": "methods", "text": "Patients older than sixty years of age at the time of injury and those who were lost to follow-up were excluded .", "sentence_id": 3}
+{"abstract_id": "25320199", "label": "methods", "text": "Functional outcomes were evaluated using the Greenough Low-Back Outcome Score and the visual analog scale for back pain .", "sentence_id": 4}
+{"abstract_id": "25320199", "label": "methods", "text": "Radiographic outcomes were focused on the vertebral body height of the injured vertebra , the kyphotic angle , and the regional segmental motion .", "sentence_id": 5}
+{"abstract_id": "25320199", "label": "results", "text": "Twenty-two patients were enrolled in the non-fusion group , and twenty-four patients were enrolled in the fusion group .", "sentence_id": 6}
+{"abstract_id": "25320199", "label": "results", "text": "The average follow-up period was @ months ( range , @ to @ months ) .", "sentence_id": 7}
+{"abstract_id": "25320199", "label": "results", "text": "The average preoperative kyphotic angle was @ for the non-fusion group and @ for the fusion group .", "sentence_id": 8}
+{"abstract_id": "25320199", "label": "results", "text": "The average postoperative kyphotic angle was @ for the non-fusion group and @ for the fusion group .", "sentence_id": 9}
+{"abstract_id": "25320199", "label": "results", "text": "At the time of the latest follow-up , the average kyphotic angle was @ for the non-fusion group and @ for the fusion group .", "sentence_id": 10}
+{"abstract_id": "25320199", "label": "results", "text": "The average kyphotic angle between the two groups was similar at all follow-up times .", "sentence_id": 11}
+{"abstract_id": "25320199", "label": "results", "text": "A progressive decrease of the kyphotic angle was significant ( p < @ ) with time , regardless of fusion .", "sentence_id": 12}
+{"abstract_id": "25320199", "label": "results", "text": "The radiographic outcomes were similar between these two groups at all follow-up times , as were functional outcomes .", "sentence_id": 13}
+{"abstract_id": "25320199", "label": "results", "text": "More patients in the non-fusion group underwent additional surgery to remove implants .", "sentence_id": 14}
+{"abstract_id": "25320199", "label": "results", "text": "Regional segmental motion was preserved in the non-fusion group , with a mean motion ( and standard deviation ) of @ @ .", "sentence_id": 15}
+{"abstract_id": "25320199", "label": "conclusions", "text": "The long-term results of short segmental fixation with and without fusion for burst fractures of the thoracolumbar and lumbar spine were comparable .", "sentence_id": 16}
+{"abstract_id": "25320199", "label": "conclusions", "text": "Regional segmental motion could be preserved without fusion , and bone graft donor site complications could be eliminated .", "sentence_id": 17}
+{"abstract_id": "25320199", "label": "methods", "text": "Therapeutic Level II .", "sentence_id": 18}
+{"abstract_id": "25320199", "label": "methods", "text": "See Instructions for Authors for a complete description of levels of evidence .", "sentence_id": 19}
+{"abstract_id": "24716775", "label": "background", "text": "Little is known about the reliability of different methods of survey administration in low back pain trials .", "sentence_id": 0}
+{"abstract_id": "24716775", "label": "background", "text": "This analysis was designed to determine the reliability of responses to self-administered paper surveys compared to computer assisted telephone interviews ( CATI ) for the primary outcomes of pain intensity and back-related function , and secondary outcomes of patient satisfaction , SF-@ , and global improvement among participants enrolled in a study of yoga for chronic low back pain .", "sentence_id": 1}
+{"abstract_id": "24716775", "label": "results", "text": "Pain intensity , back-related function , and both physical and mental health components of the SF-@ showed excellent reliability at all three time points ; ICC scores ranged from @ to @ .", "sentence_id": 2}
+{"abstract_id": "24716775", "label": "results", "text": "Pain medication use showed good reliability ; kappa statistics ranged from @ to @ .", "sentence_id": 3}
+{"abstract_id": "24716775", "label": "results", "text": "Patient satisfaction had moderate to excellent reliability ; ICC scores ranged from @ to @ .", "sentence_id": 4}
+{"abstract_id": "24716775", "label": "results", "text": "Global improvement showed poor reliability at @weeks ( ICC = @ ) and @weeks ( ICC = @ ) .", "sentence_id": 5}
+{"abstract_id": "24716775", "label": "conclusions", "text": "CATI shows excellent reliability for primary outcomes and at least some secondary outcomes when compared to self-administered paper surveys in a low back pain yoga trial .", "sentence_id": 6}
+{"abstract_id": "24716775", "label": "conclusions", "text": "Having two reliable options for data collection may be helpful to increase response rates for core outcomes in back pain trials .", "sentence_id": 7}
+{"abstract_id": "25308883", "label": "objective", "text": "To evaluate the efficacy of manual lymphatic drainage ( MLD ) in improving health-related quality of life ( HRQOL ) , symptomatology , and physical status in patients with chronic venous insufficiency ( CVI ) .", "sentence_id": 0}
+{"abstract_id": "25308883", "label": "methods", "text": "Single-blind randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25308883", "label": "methods", "text": "Health community attendant service .", "sentence_id": 2}
+{"abstract_id": "25308883", "label": "methods", "text": "Subjects with CVI ( N = @ ) were randomly assigned to an experimental group ( n = @ ; mean age , @ y ) or control group ( n = @ ; mean age , @ y ) .", "sentence_id": 3}
+{"abstract_id": "25308883", "label": "methods", "text": "The experimental group completed @ lower extremity MLD sessions over @ weeks and @ educational session .", "sentence_id": 4}
+{"abstract_id": "25308883", "label": "methods", "text": "The control group only attended the educational session .", "sentence_id": 5}
+{"abstract_id": "25308883", "label": "methods", "text": "Outcome measures were taken at baseline ( t@ ) , at the end of @ weeks ( t@ ) , and after @ months for follow-up ( t@ ) .", "sentence_id": 6}
+{"abstract_id": "25308883", "label": "methods", "text": "HRQOL was assessed with the Chronic Venous Insufficiency Quality of Life Questionnaire-@ , symptoms ( fatigue , heaviness ) were assessed with a visual analog scale , severity of the disease was assessed with the Venous Clinical Severity Score ( VCSS ) ( total score , score for each item ) , leg volumetry was assessed with perimeters , and plantar/dorsiflexion strength and ankle range of motion ( ROM ) were assessed with dynamometry .", "sentence_id": 7}
+{"abstract_id": "25308883", "label": "results", "text": "A significant interaction grouptime effect was found for pain on HRQOL ( F@ ,@ = @ ; P = @ ; partial @ = @ ) , clinical severity ( F@ ,@ = @ ; P = @ ; partial @ = @ ) , especially for venous edema ( assessed with the VCSS ) , fatigue ( F@ @,@ = @ ; P = @ ; partial @ = @ ) , and heaviness ( F@ @,@ = @ ; P = @ ; partial @ = @ ) , with the experimental group improving from t@ to t@ and t@ to t@ in all of these outcomes .", "sentence_id": 8}
+{"abstract_id": "25308883", "label": "results", "text": "No effect of MLD treatment could be found for ankle muscle strength , ankle ROM , and leg volume .", "sentence_id": 9}
+{"abstract_id": "25308883", "label": "conclusions", "text": "Short-term MLD treatment ameliorates CVI severity and related edema , symptoms , and pain HRQOL in patients with CVI .", "sentence_id": 10}
+{"abstract_id": "24582273", "label": "background", "text": "Identifying patients with recent stroke or transient ischemic attack ( TIA ) at high risk of major vascular events ( MVEs ; stroke , myocardial infarction , or vascular death ) may help optimize the intensity of secondary preventive interventions .", "sentence_id": 0}
+{"abstract_id": "24582273", "label": "background", "text": "We evaluated the relationships between the baseline Framingham Coronary Risk Score ( FCRS ) and a novel risk prediction model and with the occurrence of MVEs after stroke or TIA in subjects enrolled in the Stroke Prevention by Aggressive Reduction in Cholesterol Level ( SPARCL ) trial .", "sentence_id": 1}
+{"abstract_id": "24582273", "label": "methods", "text": "Data from the @ subjects enrolled in the SPARCL study were analyzed .", "sentence_id": 2}
+{"abstract_id": "24582273", "label": "methods", "text": "Hazard ratios ( HRs ) from Cox regression models were used to determine the risk of subsequent MVEs based on the FCRS predicting @ % or more @-year coronary heart disease risk .", "sentence_id": 3}
+{"abstract_id": "24582273", "label": "methods", "text": "The novel risk model was derived based on multivariable modeling with backward selection .", "sentence_id": 4}
+{"abstract_id": "24582273", "label": "methods", "text": "Model discrimination ( c-statistics ) was assessed using the areas under the receiver operating characteristic curves .", "sentence_id": 5}
+{"abstract_id": "24582273", "label": "results", "text": "Of @ subjects with complete data , @ % had a baseline FCRS of @ % or more .", "sentence_id": 6}
+{"abstract_id": "24582273", "label": "results", "text": "In multivariable analysis , an FCRS of @ % or more was associated with twice the risk of subsequent MVEs ( HR = @ , @ % confidence interval -LSB- CI -RSB- : @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24582273", "label": "results", "text": "The novel model based on a multivariable analysis included age ( HR = @ , @ % CI : @-@ @ per @ years ) , diabetes ( HR = @ , @ % CI : @-@ @ ) , male sex ( HR = @ , @ % CI : @-@ @ ) , and an apolipoprotein ( APO ) - B/APO-A @ ratio ( HR = @ , @ % CI : @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "24582273", "label": "results", "text": "The c-statistic was @ ( @ % CI : @ -@ ) for the FCRS of @ % or more and @ ( @ % CI : @ -@ ) for the novel model .", "sentence_id": 9}
+{"abstract_id": "24582273", "label": "conclusions", "text": "Both a baseline FCRS of @ % or more and a novel predictive model were associated with future MVEs in SPARCL trial subjects .", "sentence_id": 10}
+{"abstract_id": "24582273", "label": "conclusions", "text": "The novel model needs to be validated , and the benefits of using either the FCRS or the novel model in clinical practice needs to be assessed .", "sentence_id": 11}
+{"abstract_id": "26218727", "label": "background", "text": "Juvderm Voluma XC ( VYC-@L ) is approved in the United States for correction of age-related volume loss in the midface region in adults .", "sentence_id": 0}
+{"abstract_id": "26218727", "label": "objective", "text": "To characterize the effects of VYC-@L in @ midface subregions based on injection volumes .", "sentence_id": 1}
+{"abstract_id": "26218727", "label": "methods", "text": "In this single-blind controlled trial , subjects with midface volume deficit received VYC-@L in @ of @ facial subregions ( zygomaticomalar , anteromedial cheek , and submalar ) , with touch-up treatment available @ days later .", "sentence_id": 2}
+{"abstract_id": "26218727", "label": "methods", "text": "Responders achieved @-point improvement on the Mid-Face Volume Deficit Scale ( MFVDS ) , analyzed by facial subregion and stratified by injection volume quartiles .", "sentence_id": 3}
+{"abstract_id": "26218727", "label": "methods", "text": "Subject satisfaction and safety were assessed .", "sentence_id": 4}
+{"abstract_id": "26218727", "label": "results", "text": "The treatment arm comprised @ subjects aged @ to @ years .", "sentence_id": 5}
+{"abstract_id": "26218727", "label": "results", "text": "Month @ MFVDS responder rates were @ % for zygomaticomalar , @ % for anteromedial cheek , and @ % for submalar subregions .", "sentence_id": 6}
+{"abstract_id": "26218727", "label": "results", "text": "Higher responder rates were observed with increasing injection volume quartiles for each subregion .", "sentence_id": 7}
+{"abstract_id": "26218727", "label": "results", "text": "Similar median injection volumes ( @ mL total ) of VYC-@L provided correction durations of @ to @ months : @ months for anteromedial cheek , @ months for zygomaticomalar , and @ months for submalar subregions .", "sentence_id": 8}
+{"abstract_id": "26218727", "label": "results", "text": "Subject satisfaction was high across injection volume quartiles .", "sentence_id": 9}
+{"abstract_id": "26218727", "label": "results", "text": "No unanticipated treatment-site adverse reactions occurred .", "sentence_id": 10}
+{"abstract_id": "26218727", "label": "conclusions", "text": "VYC-@L is effective at restoring midface volume , with high subject satisfaction and an acceptable safety profile .", "sentence_id": 11}
+{"abstract_id": "24418351", "label": "objective", "text": "Intensive lifestyle change prevents type @ diabetes but is difficult to sustain .", "sentence_id": 0}
+{"abstract_id": "24418351", "label": "objective", "text": "Preliminary evidence suggests that yoga may improve metabolic factors .", "sentence_id": 1}
+{"abstract_id": "24418351", "label": "objective", "text": "We tested a restorative yoga intervention vs. active stretching for metabolic outcomes .", "sentence_id": 2}
+{"abstract_id": "24418351", "label": "methods", "text": "In @-@ , we conducted a @-week randomized trial comparing restorative yoga vs. stretching among underactive adults with the metabolic syndrome at the Universities of California , San Francisco and San Diego .", "sentence_id": 3}
+{"abstract_id": "24418351", "label": "methods", "text": "We provided lifestyle counseling and a tapering series of @-min group classes in the @-week intervention period and @-week maintenance period .", "sentence_id": 4}
+{"abstract_id": "24418351", "label": "methods", "text": "Fasting and @-h glucose , HbA@c , triglycerides , HDL-cholesterol , insulin , systolic blood pressure , visceral fat , and quality of life were assessed at baseline , @ - and @-months .", "sentence_id": 5}
+{"abstract_id": "24418351", "label": "results", "text": "@ participants were randomized and @ ( @ % ) completed the trial .", "sentence_id": 6}
+{"abstract_id": "24418351", "label": "results", "text": "At @ months , fasting glucose decreased more in the yoga group than in the stretching group ( -@ mmol/L vs. -@ mmol/L ; p = @ ) ; there were no other significant differences between groups .", "sentence_id": 7}
+{"abstract_id": "24418351", "label": "results", "text": "At @ months favorable changes within the yoga group included reductions in fasting glucose , insulin , and HbA@c and an increase in HDL-cholesterol that were not sustained at @ year except changes in fasting glucose .", "sentence_id": 8}
+{"abstract_id": "24418351", "label": "results", "text": "The stretching group had a significant reduction in triglycerides at @ months which was not sustained at @ year but had improved quality of life at both time-points .", "sentence_id": 9}
+{"abstract_id": "24418351", "label": "conclusions", "text": "Restorative yoga was marginally better than stretching for improving fasting glucose but not other metabolic factors .", "sentence_id": 10}
+{"abstract_id": "25391047", "label": "objective", "text": "While the Carotid Revascularization Endarterectomy Versus Stenting Trial ( CREST ) has been widely accepted as a landmark trial establishing an equivalent risk of major adverse events following carotid endarterectomy ( CEA ) or carotid artery stenting ( CAS ) , the applicability of these findings to single centers has been questioned owing to the rigid selection criteria for investigators in the study .", "sentence_id": 0}
+{"abstract_id": "25391047", "label": "objective", "text": "Although refuted by the findings of a subsequent study , a substudy of CREST established a higher periprocedural stroke rate for CAS when the surgeon was a vascular surgeon .", "sentence_id": 1}
+{"abstract_id": "25391047", "label": "objective", "text": "To present our @-day results of stroke , death , myocardial infarction , and composite major adverse events to determine if a single vascular surgeon 's outcomes at our hospital are consistent with the results of CREST .", "sentence_id": 2}
+{"abstract_id": "25391047", "label": "methods", "text": "A retrospective analysis of patients with high-grade carotid artery stenosis treated with CEA or CAS by a vascular surgeon at our institution from September @ , @ , through December @ , @ , was performed .", "sentence_id": 3}
+{"abstract_id": "25391047", "label": "methods", "text": "A @ analysis was used to compare the incidence of specific high-risk patient characteristics in each group .", "sentence_id": 4}
+{"abstract_id": "25391047", "label": "methods", "text": "The Fisher exact test was used to compare the risks of stroke , death , myocardial infarction , and composite major adverse events between CEA and CAS .", "sentence_id": 5}
+{"abstract_id": "25391047", "label": "methods", "text": "These results were then compared with those reported in CREST .", "sentence_id": 6}
+{"abstract_id": "25391047", "label": "results", "text": "A total of @ cases ( @ CAS and @ CEA ) performed by a single vascular surgeon were included for analysis .", "sentence_id": 7}
+{"abstract_id": "25391047", "label": "results", "text": "While in CREST the periprocedural risk of stroke was higher following CAS ( @ % vs @ % , P = @ ) and the risk of myocardial infarction was higher following CEA ( @ % vs @ % , P = @ ) , there was no significant difference in the incidence of these outcomes between the @ treatment modalities in our study .", "sentence_id": 8}
+{"abstract_id": "25391047", "label": "results", "text": "When compared with CREST , our rates of myocardial infarction , stroke , death , and composite adverse events ( CEA , @ % vs @ % ; P = @ ; CAS , @ % vs @ % ; P > @ ) were no different .", "sentence_id": 9}
+{"abstract_id": "25391047", "label": "conclusions", "text": "Similar to CREST , the @-day risk of composite major adverse events was equivalent for the @ treatment modalities .", "sentence_id": 10}
+{"abstract_id": "25391047", "label": "conclusions", "text": "We attribute our comparable incidence of perioperative stroke with CAS and CEA to improved patient selection .", "sentence_id": 11}
+{"abstract_id": "25391047", "label": "conclusions", "text": "We excluded most patients older than @ years and those with complex anatomy from consideration for CAS .", "sentence_id": 12}
+{"abstract_id": "25391047", "label": "conclusions", "text": "Our results confirm those of CREST and demonstrate that both CEA and CAS can be performed safely by a vascular surgeon in properly selected patients .", "sentence_id": 13}
+{"abstract_id": "24337423", "label": "background", "text": "The efficacy of functional restoration programs for the treatment of chronic back pain is well documented .", "sentence_id": 0}
+{"abstract_id": "24337423", "label": "background", "text": "Nevertheless , there are only a few such centres in Germany and few trials have been conducted in German-speaking regions to demonstrate that implementing such programs in everyday clinical settings with large numbers of patients is just as effective as in a research setting .", "sentence_id": 1}
+{"abstract_id": "24337423", "label": "background", "text": "The present study examined whether the positive effects of such programs can also be observed in the clinically relevant context of a standardized day clinic treatment regimen .", "sentence_id": 2}
+{"abstract_id": "24337423", "label": "methods", "text": "A total of @ back pain patients in @ German cities were examined at @ measurement points ( before and immediately after the program , as well as @ and @ months after treatment ) using a comprehensive questionnaire on perceived pain and symptoms of anxiety and depression , as well as the work situation .", "sentence_id": 3}
+{"abstract_id": "24337423", "label": "results", "text": "In both cities significant and long-term improvements in back pain , pain-related impairment and degree of chronification were observed , as well as a high return-to-work rate after treatment .", "sentence_id": 4}
+{"abstract_id": "24337423", "label": "results", "text": "Hence , the quality of such programs was also confirmed for a large patient population .", "sentence_id": 5}
+{"abstract_id": "25112865", "label": "objective", "text": "We conducted a @-month , randomized , double-blind , placebo-controlled study to assess safety , tolerability , and efficacy of deferiprone in Friedreich ataxia ( FRDA ) .", "sentence_id": 0}
+{"abstract_id": "25112865", "label": "methods", "text": "Seventy-two patients were treated with deferiprone @ , @ , or @mg/kg/day or placebo , divided into @ daily doses .", "sentence_id": 1}
+{"abstract_id": "25112865", "label": "methods", "text": "Safety was the primary objective ; secondary objectives included standardized neurological assessments ( Friedreich Ataxia Rating Scale -LSB- FARS -RSB- , International Cooperative Ataxia Rating Scale -LSB- ICARS -RSB- , @-Hole Peg Test -LSB- @HPT -RSB- , Timed @-Foot Walk , Low-Contrast Letter Acuity ) , general functional status ( Activities of Daily Living ) , and cardiac assessments .", "sentence_id": 2}
+{"abstract_id": "25112865", "label": "results", "text": "Deferiprone was well tolerated at @mg/kg/day , whereas more adverse events occurred in the @mg/kg/day than in the placebo group .", "sentence_id": 3}
+{"abstract_id": "25112865", "label": "results", "text": "The @mg/kg/day dose was discontinued due to worsening of ataxia in @ patients .", "sentence_id": 4}
+{"abstract_id": "25112865", "label": "results", "text": "One patient on deferiprone @mg/kg/day experienced reversible neutropenia , but none developed agranulocytosis .", "sentence_id": 5}
+{"abstract_id": "25112865", "label": "results", "text": "Deferiprone-treated patients receiving @ or @mg/kg/day showed a decline in the left ventricular mass index , compared to an increase in the placebo-treated patients .", "sentence_id": 6}
+{"abstract_id": "25112865", "label": "results", "text": "Patients receiving @mg/kg/day of deferiprone had no significant change in FARS , similar to the placebo-treated patients , whereas those receiving @mg/kg/day had worsening in FARS and ICARS scores .", "sentence_id": 7}
+{"abstract_id": "25112865", "label": "results", "text": "The lack of deterioration in the placebo arm impaired the ability to detect any potential protective effect of deferiprone .", "sentence_id": 8}
+{"abstract_id": "25112865", "label": "results", "text": "However , subgroup analyses in patients with less severe disease suggested a benefit of deferiprone @mg/kg/day on ICARS , FARS , kinetic function , and @HPT .", "sentence_id": 9}
+{"abstract_id": "25112865", "label": "conclusions", "text": "This study demonstrated an acceptable safety profile of deferiprone at @mg/kg/day for the treatment of patients with FRDA .", "sentence_id": 10}
+{"abstract_id": "25112865", "label": "conclusions", "text": "Subgroup analyses raise the possibility that , in patients with less severe disease , deferiprone @mg/kg/day may reduce disease progression , whereas higher doses appear to worsen ataxia .", "sentence_id": 11}
+{"abstract_id": "24317232", "label": "objective", "text": "We describe a new approach to blocking the sciatic and saphenous nerves in the proximal thigh ( level of the lesser trochanter or immediately below ) using a single-penetration dual-injection ( SPEDI ) technique .", "sentence_id": 0}
+{"abstract_id": "24317232", "label": "objective", "text": "The popliteal-sciatic approach necessitates repositioning of the leg exposing the popliteal fossa and an extra injection for the saphenous nerve ( SAN ) block at the midthigh level .", "sentence_id": 1}
+{"abstract_id": "24317232", "label": "objective", "text": "We introduce an alternative , effective , and possibly faster method .", "sentence_id": 2}
+{"abstract_id": "24317232", "label": "methods", "text": "Sixty patients undergoing leg and foot surgery under general anesthesia were included .", "sentence_id": 3}
+{"abstract_id": "24317232", "label": "methods", "text": "We deposited @ mL of ropivacaine @ % around the sciatic nerve ( SCN ) and @ mL of ropivacaine @ % at the SAN .", "sentence_id": 4}
+{"abstract_id": "24317232", "label": "methods", "text": "Patients were randomized to the popliteal-sciatic/saphenous technique or the SPEDI technique .", "sentence_id": 5}
+{"abstract_id": "24317232", "label": "methods", "text": "The primary outcome measure was performance time .", "sentence_id": 6}
+{"abstract_id": "24317232", "label": "methods", "text": "Positioning time , pain assessment , nausea in the postanesthesia care unit , sufentanil demand , dermatomal anesthesia , and degree of motor blockade were also recorded .", "sentence_id": 7}
+{"abstract_id": "24317232", "label": "results", "text": "Performance time was significantly faster with the SPEDI technique ( median time , @ seconds -LSB- range , @-@ seconds -RSB- vs @ seconds -LSB- range , @-@ seconds -RSB- ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24317232", "label": "results", "text": "Positioning time was significantly shorter with the SPEDI technique ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24317232", "label": "results", "text": "No other statistically significant differences were recorded .", "sentence_id": 10}
+{"abstract_id": "24317232", "label": "conclusions", "text": "The SPEDI block resulted in significantly faster performance time and reduced positioning time with statistically equal efficacy in relation to pain assessment , nausea , sufentanil demand , dermatomal anesthesia , and motor blockade .", "sentence_id": 11}
+{"abstract_id": "24317232", "label": "conclusions", "text": "The SPEDI block is statistically an equally effective alternative to the traditional popliteal-sciatic/saphenous block combination for leg and foot surgery , but it is faster , requires only @ skin penetration , and does not require repositioning of the leg .", "sentence_id": 12}
+{"abstract_id": "25397864", "label": "background", "text": "Near-infrared ( NIR ) light therapy is purported to act as an ergogenic aid by enhancing the contractile function of skeletal muscle .", "sentence_id": 0}
+{"abstract_id": "25397864", "label": "background", "text": "Improving muscle function is a new avenue for research in the area of laser therapy ; however , very few researchers have examined the ergogenic effects of NIR light therapy and the influence it may have on the recovery process during rehabilitation .", "sentence_id": 1}
+{"abstract_id": "25397864", "label": "objective", "text": "To evaluate the ergogenic effect of NIR light therapy on skeletal muscle function .", "sentence_id": 2}
+{"abstract_id": "25397864", "label": "methods", "text": "Crossover study .", "sentence_id": 3}
+{"abstract_id": "25397864", "label": "methods", "text": "Controlled laboratory .", "sentence_id": 4}
+{"abstract_id": "25397864", "label": "methods", "text": "Thirty-nine healthy men ( n = @ ) and women ( n = @ ; age = @ @ years , height = @ @ cm , mass = @ @ kg , body mass index = @ @ kg/m ( @ ) ) .", "sentence_id": 5}
+{"abstract_id": "25397864", "label": "methods", "text": "Each participant received active and sham treatments on the biceps brachii muscle on @ separate days .", "sentence_id": 6}
+{"abstract_id": "25397864", "label": "methods", "text": "The order of treatment was randomized .", "sentence_id": 7}
+{"abstract_id": "25397864", "label": "methods", "text": "A class @ laser with a cumulative dose of @ J was used for the active treatment .", "sentence_id": 8}
+{"abstract_id": "25397864", "label": "methods", "text": "After receiving the treatment on each day , participants completed an elbow-flexion resistance-exercise protocol .", "sentence_id": 9}
+{"abstract_id": "25397864", "label": "methods", "text": "The dependent variables were elbow range of motion , muscle point tenderness , and strength ( peak torque ) .", "sentence_id": 10}
+{"abstract_id": "25397864", "label": "methods", "text": "Analysis of variance with repeated measures was used to assess changes in these measures between treatments at baseline and at follow-up , @ hours postexercise .", "sentence_id": 11}
+{"abstract_id": "25397864", "label": "methods", "text": "Additionally , immediate strength loss postexercise was compared between treatments using a paired t test .", "sentence_id": 12}
+{"abstract_id": "25397864", "label": "results", "text": "Preexercise to postexercise strength loss for the active laser treatment , although small , was less than with the sham treatment ( P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25397864", "label": "conclusions", "text": "Applied to skeletal muscle before resistance exercise , NIR light therapy effectively attenuated strength loss .", "sentence_id": 14}
+{"abstract_id": "25397864", "label": "conclusions", "text": "Therefore , NIR light therapy may be a beneficial , noninvasive modality for improving muscle function during rehabilitation after musculoskeletal injury .", "sentence_id": 15}
+{"abstract_id": "25397864", "label": "conclusions", "text": "However , future studies using higher treatment doses are warranted .", "sentence_id": 16}
+{"abstract_id": "25833970", "label": "background", "text": "Efficient fat digestion requires fat processing within the stomach and fat sensing in the intestine .", "sentence_id": 0}
+{"abstract_id": "25833970", "label": "background", "text": "Both processes also control gastric emptying and gastrointestinal secretions .", "sentence_id": 1}
+{"abstract_id": "25833970", "label": "objective", "text": "We aimed to visualize the influence of the intragastric stability of fat emulsions on their dynamics of gastric processing and structuring and to assess the effect this has on gastrointestinal motor and secretory functions .", "sentence_id": 2}
+{"abstract_id": "25833970", "label": "methods", "text": "Eighteen healthy subjects with normal body mass index ( BMI ) were studied on @ separate occasions in a double-blind , randomized , crossover design .", "sentence_id": 3}
+{"abstract_id": "25833970", "label": "methods", "text": "Magnetic resonance imaging ( MRI ) data of the gastrointestinal tract and blood triglycerides were recorded before and for @ min after the consumption of the following @ different fat emulsions : lipid emulsion @ ( LE@ ; acid stable , @ m ) , lipid emulsion @ ( LE@ ; acid stable , @ m ) , lipid emulsion @ ( LE@ ; acid unstable , solid fat , @ m ) , and lipid emulsion @ ( LE@ ; acid unstable , liquid fat , @ m ) .", "sentence_id": 4}
+{"abstract_id": "25833970", "label": "results", "text": "Intragastric emulsion instability was associated with a change in gastric emptying .", "sentence_id": 5}
+{"abstract_id": "25833970", "label": "results", "text": "Acid-unstable emulsions exhibited biphasic and faster emptying profiles than did the @ acid-stable emulsions ( P @ ) .", "sentence_id": 6}
+{"abstract_id": "25833970", "label": "results", "text": "When combined with solid fat ( LE@ ) , different dynamics of postprandial gallbladder volume were induced ( P @ ) .", "sentence_id": 7}
+{"abstract_id": "25833970", "label": "results", "text": "For acid-stable emulsions , a reduction of droplet size by @ orders of magnitude -LSB- LE@ ( @ m ) compared with LE@ ( @ m ) -RSB- delayed gastric emptying by @ min .", "sentence_id": 8}
+{"abstract_id": "25833970", "label": "results", "text": "Although acid-stable ( LE@ and LE@ ) and redispersible ( LE@ ) emulsions caused a constant increase in blood triglycerides , no increase was detectable for LE@ ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25833970", "label": "results", "text": "For LE@ , MRI confirmed the generation of large fat particles during gastric processing , which emptied into and progressed through the small intestine .", "sentence_id": 10}
+{"abstract_id": "25833970", "label": "conclusions", "text": "MRI allows the detailed characterization of the in vivo fate of lipid emulsions .", "sentence_id": 11}
+{"abstract_id": "25833970", "label": "conclusions", "text": "The acute effects of lipid emulsions on gastric emptying , gallbladder volume , and triglyceride absorption are dependent on microstructural changes undergone during consumption .", "sentence_id": 12}
+{"abstract_id": "25833970", "label": "conclusions", "text": "Gastric peristalsis and secretion were effective at redispersing pools of liquid fat in the stomach .", "sentence_id": 13}
+{"abstract_id": "25833970", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 14}
+{"abstract_id": "24535356", "label": "objective", "text": "To explore a new method of patient-involved digital design , esthetic outcome prediction and fabrication for the esthetic rehabilitation of anterior teeth , and to provide an alternative choice for the restoration of anterior teeth .", "sentence_id": 0}
+{"abstract_id": "24535356", "label": "methods", "text": "In this study , @ patients with esthetic problems in their anterior teeth were included and divided into two groups randomly : the experimental group ( @ patients ) and control group ( @ patients ) .", "sentence_id": 1}
+{"abstract_id": "24535356", "label": "methods", "text": "In the experimental group , the dentition and facial images were obtained by intra-oral scanning and Three-dimensional ( @D ) facial scanning and then calibrated .", "sentence_id": 2}
+{"abstract_id": "24535356", "label": "methods", "text": "The design of the rehabilitation and the esthetic outcome prediction were created by computer-aided design ( CAD ) software .", "sentence_id": 3}
+{"abstract_id": "24535356", "label": "methods", "text": "After morphologic modification according to the patients ' opinions , prostheses were fabricated according to the final design by computer-aided manufacturing ( CAM ) equipment .", "sentence_id": 4}
+{"abstract_id": "24535356", "label": "methods", "text": "As for the control group , the regular design method was applied to restore their anterior teeth .", "sentence_id": 5}
+{"abstract_id": "24535356", "label": "methods", "text": "The time consuming in the first insertion of each restoration in both groups was recorded .", "sentence_id": 6}
+{"abstract_id": "24535356", "label": "methods", "text": "The quality of the prostheses was assessed by another prosthedontist .", "sentence_id": 7}
+{"abstract_id": "24535356", "label": "methods", "text": "The satisfaction to prostheses and the facial appearance were evaluated by the patients .", "sentence_id": 8}
+{"abstract_id": "24535356", "label": "results", "text": "The process of the patient-involved digital design and outcome anticipation was successfully established .", "sentence_id": 9}
+{"abstract_id": "24535356", "label": "results", "text": "The patients were satisfied with the esthetic effects of the anterior restoration made by the digital technique .", "sentence_id": 10}
+{"abstract_id": "24535356", "label": "results", "text": "The acceptance rate of the patients on the digital rehabilitation in the experimental group was @ % .", "sentence_id": 11}
+{"abstract_id": "24535356", "label": "results", "text": "There was no significant difference of the quality of the prostheses between the two groups .", "sentence_id": 12}
+{"abstract_id": "24535356", "label": "results", "text": "The satisfaction rate of the patients on prostheses and facial appearance was significantly higher in the experimental group than in the control group ( P < @ ) .", "sentence_id": 13}
+{"abstract_id": "24535356", "label": "results", "text": "In addition , the time consuming in the first insertion of the experimental group was much shorter than that in the control group ( P < @ ) .", "sentence_id": 14}
+{"abstract_id": "24535356", "label": "conclusions", "text": "The new method of the patient-involved digital design , esthetic outcome prediction and fabrication for the esthetic rehabilitation of anterior teeth is a practical technique .", "sentence_id": 15}
+{"abstract_id": "24535356", "label": "conclusions", "text": "This method is useful in shortening the time consuming of the restoration of anterior teeth and improving the patient satisfaction with the esthetic outcome .", "sentence_id": 16}
+{"abstract_id": "25440374", "label": "objective", "text": "The purpose of the study was to evaluate the clinical effects of the Shenzhu Tiaopi granule ( SZTP ) combined with a lifestyle intervention in patients with impaired glucose tolerance ( IGT ) , who also had a spleen deficiency and damp overabundance syndrome ( SDDOS ) .", "sentence_id": 0}
+{"abstract_id": "25440374", "label": "methods", "text": "After a one-month washout period , a total of @ patients were randomly assigned to the control ( lifestyle intervention ) and experimental ( SZTP plus lifestyle intervention ) groups , with @ patients in each group .", "sentence_id": 1}
+{"abstract_id": "25440374", "label": "methods", "text": "Patients in the control group received the lifestyle intervention ( diet and exercise ) for @ months , while the patients in the experimental group were treated with SZTP plus the lifestyle intervention for @ months .", "sentence_id": 2}
+{"abstract_id": "25440374", "label": "methods", "text": "The Traditional Chinese Medicinal ( TCM ) symptom scores were observed in each group before and after treatment ; the conversion rates from IGT to diabetes mellitus ( DM ) were also measured .", "sentence_id": 3}
+{"abstract_id": "25440374", "label": "results", "text": "Following @ months of treatment , the conversion rate from IGT to DM in the experimental group was significantly lower than in the control group ( @ % vs. @ % , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25440374", "label": "results", "text": "A significantly higher number of patients with IGT reverted to normal blood glucose levels in the experimental group than in the control group ( @ % vs. @ % , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25440374", "label": "results", "text": "In addition , after following the treatment for @ months , the TCM symptoms of patients in the experimental group were markedly alleviated , as compared to the control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25440374", "label": "conclusions", "text": "The combination of SZTP and lifestyle intervention showed a reduction in the conversion from IGT to DM , and an increase in the conversion from IGT to normal blood glucose levels .", "sentence_id": 7}
+{"abstract_id": "24418672", "label": "objective", "text": "To determine whether a single bout of resistance exercise produces an analgesic effect in individuals with knee osteoarthritis ( OA ) .", "sentence_id": 0}
+{"abstract_id": "24418672", "label": "methods", "text": "Eleven participants with knee OA ( @ @ yrs ) , and @ old ( @ @ yrs ) and @ young ( @ @ yrs ) healthy adults performed separate bouts of upper and lower body resistance exercise .", "sentence_id": 1}
+{"abstract_id": "24418672", "label": "methods", "text": "Baseline and post-exercise pressure pain thresholds were measured at eight sites across the body and pressure pain tolerance was measured at the knee .", "sentence_id": 2}
+{"abstract_id": "24418672", "label": "results", "text": "Pressure pain thresholds increased following exercise for all three groups , indicating reduced pain sensitivity .", "sentence_id": 3}
+{"abstract_id": "24418672", "label": "results", "text": "For the young and old healthy groups this exercise-induced analgesia ( EIA ) occurred following upper or lower body resistance exercise .", "sentence_id": 4}
+{"abstract_id": "24418672", "label": "results", "text": "In contrast , only upper body exercise significantly raised pain thresholds in the knee OA group , with variable non-significant effects following lower body exercise .", "sentence_id": 5}
+{"abstract_id": "24418672", "label": "results", "text": "Pressure pain tolerance was unchanged in all groups following either upper or lower body exercise .", "sentence_id": 6}
+{"abstract_id": "24418672", "label": "conclusions", "text": "An acute bout of upper or lower body exercise evoked a systemic decrease in pain sensitivity in healthy individuals irrespective of age .", "sentence_id": 7}
+{"abstract_id": "24418672", "label": "conclusions", "text": "The decreased pain sensitivity following resistance exercise can be attributed to changes in pain thresholds , not pain tolerance .", "sentence_id": 8}
+{"abstract_id": "24418672", "label": "conclusions", "text": "While individuals with knee OA experienced EIA , a systemic decrease in pain sensitivity was only evident following upper body exercise .", "sentence_id": 9}
+{"abstract_id": "24980238", "label": "background", "text": "After vidian neurectomy , low reported rates of dry eye syndrome ( DES ) seemed incompatible with the high success rate of nerve severance in previous studies .", "sentence_id": 0}
+{"abstract_id": "24980238", "label": "background", "text": "This study aimed at understanding of the pathophysiology of lacrimation and evaluating the effect of thermal injury through the distal stump on the sphenopalatine ganglion ( SPG ) after vidian neurectomy .", "sentence_id": 1}
+{"abstract_id": "24980238", "label": "methods", "text": "A randomized , double-blind , controlled study was performed to evaluate the DES .", "sentence_id": 2}
+{"abstract_id": "24980238", "label": "methods", "text": "Eighty precise vidian neurectomies were randomized in a @:@ ratio to groups @ and @ .", "sentence_id": 3}
+{"abstract_id": "24980238", "label": "methods", "text": "Group @ represented the cauterization and was used in both distal and proximal nerve stumps , whereas only the proximal nerve stump was cauterized in group @ subjects .", "sentence_id": 4}
+{"abstract_id": "24980238", "label": "methods", "text": "The DES was evaluated with Schirmer 's test and ocular surface disease index ( OSDI ) before and after surgery at @-@ days and @ days , respectively .", "sentence_id": 5}
+{"abstract_id": "24980238", "label": "results", "text": "In group @ , the Schirmer 's test showed a mean decline of @ mm ( @/@ , @ % ) at @-@ days and @ mm ( @/@ , @ % ) at @ days .", "sentence_id": 6}
+{"abstract_id": "24980238", "label": "results", "text": "In group @ , the Schirmer 's test revealed significantly lesser dry eye problems , with a mean decline of @ mm ( @/@ ; @ % ) at @-@ days and @ mm ( @/@ ; @ % ) at @ days .", "sentence_id": 7}
+{"abstract_id": "24980238", "label": "results", "text": "The significantly less postoperative dry eye problems in group @ can be shown by the OSDI at @-@ days , but not at @ days .", "sentence_id": 8}
+{"abstract_id": "24980238", "label": "results", "text": "The mean follow-up period was @ months .", "sentence_id": 9}
+{"abstract_id": "24980238", "label": "results", "text": "No recurrence of nasal allergy symptoms was noted in the follow up period .", "sentence_id": 10}
+{"abstract_id": "24980238", "label": "conclusions", "text": "The significant advantage of preservation of the SPG function is justified by Schirmer 's test , although the effect did not appear to be comparable with the clinical manifestations evaluated by OSDI at @ days .", "sentence_id": 11}
+{"abstract_id": "24980238", "label": "conclusions", "text": "Nevertheless , the preservation of distal stump from preventive cauterization can still offer better eye ball moisture in the early evaluation of DES .", "sentence_id": 12}
+{"abstract_id": "24628966", "label": "objective", "text": "To investigate the effect of flavonoid-rich dark chocolate and non-flavonoid-rich white chocolate on retinal vessel diameter in glaucoma patients and age-matched controls .", "sentence_id": 0}
+{"abstract_id": "24628966", "label": "methods", "text": "Thirty glaucoma patients and @ age-matched subjects were assigned to dark or white chocolate by randomization with forced equal distribution .", "sentence_id": 1}
+{"abstract_id": "24628966", "label": "methods", "text": "The number in each of the four groups was @ .", "sentence_id": 2}
+{"abstract_id": "24628966", "label": "methods", "text": "Measured parameters included systemic blood pressure ( BP ) , blood glucose levels , static retinal vessel analysis , as measured by central retinal artery equivalent ( CRAE ) ( which relates to the diameter of the central retinal artery ) , central retinal vein equivalent ( CRVE ) ( which relates to the diameter of central retinal vein ) and the arterio-venous ratio ( AVR ) , which represents the CRAE/CRVE ratio , dynamic retinal vessel analysis as measured by the change in vessel diameter in response to flicker light stimulation .", "sentence_id": 3}
+{"abstract_id": "24628966", "label": "methods", "text": "Three recording cycles from each were averaged .", "sentence_id": 4}
+{"abstract_id": "24628966", "label": "results", "text": "Blood pressure parameters ( systolic BP , diastolic BP and pulse ) , IOP and blood glucose levels did not differ significantly between both groups before and after consumption of white or dark chocolate .", "sentence_id": 5}
+{"abstract_id": "24628966", "label": "results", "text": "Static vessel analysis did not show any significant changes in CRAE , CRVE or AVR before and after dark or white chocolate in both groups ( p > @ ) .", "sentence_id": 6}
+{"abstract_id": "24628966", "label": "results", "text": "Mean dilatation of the venules in the control group was @ @ % before dark chocolate and @ @ % after dark chocolate intake , which was statistically significantly different ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24628966", "label": "results", "text": "Mean dilatation of the arterioles in the control group was @ @ % before dark chocolate and @ @ % after dark chocolate intake with a trend to statistical significance ( p = @ ) , but not reaching the significance level .", "sentence_id": 8}
+{"abstract_id": "24628966", "label": "results", "text": "Mean diameter changes in the glaucoma group did not show any significant differences after dark chocolate consumption .", "sentence_id": 9}
+{"abstract_id": "24628966", "label": "conclusions", "text": "The present study showed a significant improvement of venous vasodilatation @ hr after dark chocolate intake in the control group , but not in the glaucoma group .", "sentence_id": 10}
+{"abstract_id": "24628966", "label": "conclusions", "text": "This effect might be indicative of an increased bioavailability of nitric oxide ( NO ) after dark chocolate consumption .", "sentence_id": 11}
+{"abstract_id": "24628966", "label": "conclusions", "text": "The lack of finding a significant venous response after dark chocolate in the glaucoma group might be related to the already impaired endothelial function in these patients .", "sentence_id": 12}
+{"abstract_id": "25273991", "label": "background", "text": "The United States has the highest rate of lumbar spine surgery in the world , with rates increasing over @ % since @ .", "sentence_id": 0}
+{"abstract_id": "25273991", "label": "background", "text": "Medicare spends over $ @ billion annually on lumbar spine surgery .", "sentence_id": 1}
+{"abstract_id": "25273991", "label": "background", "text": "Despite surgical advances , up to @ % of patients report chronic pain and disability following surgery .", "sentence_id": 2}
+{"abstract_id": "25273991", "label": "background", "text": "Our work has demonstrated that fear of movement is a risk factor for increased pain and disability and decreased physical function in patients following lumbar spine surgery for degenerative conditions .", "sentence_id": 3}
+{"abstract_id": "25273991", "label": "background", "text": "Cognitive-behavioral therapy and self-management treatments have the potential to address psychosocial risk factors and improve outcomes after spine surgery , but are unavailable or insufficiently adapted for postoperative care .", "sentence_id": 4}
+{"abstract_id": "25273991", "label": "background", "text": "Our research team developed a cognitive-behavioral based self-management approach to postoperative rehabilitation ( Changing Behavior through Physical Therapy ( CBPT ) ) .", "sentence_id": 5}
+{"abstract_id": "25273991", "label": "background", "text": "Pilot testing of the CBPT program demonstrated greater improvement in pain , disability , physical and mental health , and physical performance compared to education .", "sentence_id": 6}
+{"abstract_id": "25273991", "label": "background", "text": "The current study compares which of two treatments provided by telephone - a CBPT Program or an Education Program about postoperative recovery - are more effective for improving patient-centered outcomes in adults following lumbar spine surgery for degenerative conditions .", "sentence_id": 7}
+{"abstract_id": "25273991", "label": "methods", "text": "A multi-center , comparative effectiveness trial will be conducted .", "sentence_id": 8}
+{"abstract_id": "25273991", "label": "methods", "text": "Two hundred and sixty patients undergoing lumbar spine surgery for degenerative conditions will be recruited from two medical centers and community surgical practices .", "sentence_id": 9}
+{"abstract_id": "25273991", "label": "methods", "text": "Participants will be randomly assigned to CBPT or Education at @weeks following surgery .", "sentence_id": 10}
+{"abstract_id": "25273991", "label": "methods", "text": "Treatments consist of six weekly telephone sessions with a trained physical therapist .", "sentence_id": 11}
+{"abstract_id": "25273991", "label": "methods", "text": "The primary outcome will be disability and secondary outcomes include pain , general health , and physical activity .", "sentence_id": 12}
+{"abstract_id": "25273991", "label": "methods", "text": "Outcomes will be assessed preoperatively and at @weeks , @months and @months after surgery by an assessor masked to group allocation .", "sentence_id": 13}
+{"abstract_id": "25273991", "label": "conclusions", "text": "Effective rehabilitation treatments that can guide clinicians in their recommendations , and patients in their actions will have the potential to effect change in current clinical practice .", "sentence_id": 14}
+{"abstract_id": "26196084", "label": "objective", "text": "To evaluate operative time after adjunctive misoprostol or mifepristone compared with overnight osmotic dilators alone for cervical preparation before dilation and evacuation at @-@ @/@ weeks of gestation .", "sentence_id": 0}
+{"abstract_id": "26196084", "label": "methods", "text": "This double-blind , three-arm , multicenter , randomized trial compared overnight osmotic dilators alone , dilators plus @ micrograms buccal misoprostol @ hours preoperatively , and dilators plus @ mg oral mifepristone during dilator placement for dilation and evacuation .", "sentence_id": 1}
+{"abstract_id": "26196084", "label": "methods", "text": "Our primary outcome was dilation and evacuation operative time within two cohorts : @-@ @/@ weeks of gestation ( N = @ ) and @-@ @/@ weeks of gestation ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "26196084", "label": "methods", "text": "Three hundred women were required for @ % power to detect a @-minute difference in operative time .", "sentence_id": 3}
+{"abstract_id": "26196084", "label": "methods", "text": "Secondary outcomes included initial cervical dilation , side effects , physician satisfaction by Likert scale , and complications .", "sentence_id": 4}
+{"abstract_id": "26196084", "label": "results", "text": "Between February @ and February @ we randomized @ women evenly across treatment arms .", "sentence_id": 5}
+{"abstract_id": "26196084", "label": "results", "text": "Group demographics were similar .", "sentence_id": 6}
+{"abstract_id": "26196084", "label": "results", "text": "We found no difference in operative time in either gestational cohort ( early cohort -LSB- minutes -RSB- : @ dilators alone , @ misoprostol , @ mifepristone , P = @ ; late cohort -LSB- minutes -RSB- : @ dilators alone , @ misoprostol , @ mifepristone , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26196084", "label": "results", "text": "In the early cohort , initial dilation was greater with misoprostol than dilators alone ( @ compared with @ cm , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "26196084", "label": "results", "text": "Patients given misoprostol had significantly more pain , fever , and chills .", "sentence_id": 9}
+{"abstract_id": "26196084", "label": "results", "text": "In the late cohort , dilation and evacuation procedures were less difficult after mifepristone ( @ % , @ % confidence interval -LSB- CI -RSB- @-@ @ ) than misoprostol ( @ % , @ % CI @-@ @ ) or dilators alone ( @ % , @ % CI @-@ @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "26196084", "label": "results", "text": "We had inadequate power to infer differences in complications : dilators alone ( @ % , @ % CI @-@ @ ) compared with misoprostol ( @ % , @ % CI @-@ @ ) compared with mifepristone ( @ % , @ % CI @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "26196084", "label": "conclusions", "text": "Despite no difference in operative time , adjunctive mifepristone facilitates later dilation and evacuation compared with osmotic dilators alone and is better tolerated than misoprostol .", "sentence_id": 12}
+{"abstract_id": "25584489", "label": "background", "text": "Rilotumumab , an investigational , monoclonal antibody , inhibits MET-mediated signalling .", "sentence_id": 0}
+{"abstract_id": "25584489", "label": "background", "text": "In a randomized phase @ trial of rilotumumabepirubicin/cisplatin/capecitabine in gastric or oesophagogastric junction cancer , patients receiving rilotumumab showed a trend towards improved survival , especially in MET-positive patients , but no clear dose-response relationship was observed .", "sentence_id": 1}
+{"abstract_id": "25584489", "label": "background", "text": "Exposure-response and biomarker analyses were used for dose selection and to differentiate patient subpopulations that may benefit most from treatment .", "sentence_id": 2}
+{"abstract_id": "25584489", "label": "background", "text": "Here , we analyse rilotumumab exposure-survival and exposure-safety and the impact of MET expression on these relationships .", "sentence_id": 3}
+{"abstract_id": "25584489", "label": "methods", "text": "Individual rilotumumab exposure parameters were generated using population pharmacokinetic modelling .", "sentence_id": 4}
+{"abstract_id": "25584489", "label": "methods", "text": "Relationships among rilotumumab dose ( @ and @mgkg ( -@ ) ) , exposure , and clinical outcomes ( progression-free survival ( PFS ) and overall survival ( OS ) ) were evaluated with Cox regression models and Kaplan-Meier plots .", "sentence_id": 5}
+{"abstract_id": "25584489", "label": "methods", "text": "MET status and other baseline covariates were evaluated in subgroup and multivariate analyses .", "sentence_id": 6}
+{"abstract_id": "25584489", "label": "methods", "text": "Treatment-emergent adverse events were summarised by exposure .", "sentence_id": 7}
+{"abstract_id": "25584489", "label": "results", "text": "Among MET-positive patients , higher rilotumumab exposure , vs placebo and low exposure , was associated with improved median PFS ( @ % CI : @ ( @-@ @ ) vs @ ( @-@ @ ) and @ ( @-@ @ ) months ) and OS ( @ ( @-@ @ ) vs @ ( @-@ @ ) and @ ( @-@ @ ) months ) without increased toxicity .", "sentence_id": 8}
+{"abstract_id": "25584489", "label": "results", "text": "No rilotumumab benefit was seen among MET-negative patients .", "sentence_id": 9}
+{"abstract_id": "25584489", "label": "conclusions", "text": "Rilotumumab had an exposure-dependent treatment effect in patients with MET-positive gastric or oesophagogastric junction cancer .", "sentence_id": 10}
+{"abstract_id": "25450879", "label": "background", "text": "Neoangiogenesis is particularly abundant in small-cell lung cancer ( SCLC ) and is associated with poor prognosis .", "sentence_id": 0}
+{"abstract_id": "25450879", "label": "background", "text": "As a result of the promising nature of phase II studies , a randomized phase III trial was designed to assess the efficacy of adding bevacizumab to first-line chemotherapy with cisplatin-etoposide for treatment of extensive disease SCLC .", "sentence_id": 1}
+{"abstract_id": "25450879", "label": "background", "text": "We present the treatment rationale and study design of GOIRC trial ( FARM@PMFJM study ) , a multicenter randomized phase III study , supported by AIFA ( Agenzia Italiana del Farmaco ) .", "sentence_id": 2}
+{"abstract_id": "25450879", "label": "methods", "text": "Patients are randomized to receive either cisplatin @ mg/m ( @ ) and etoposide @ mg/m ( @ ) intravenously on days @ to @ ( control arm ) or the same chemotherapy combined with bevacizumab @ mg/kg intravenously on day @ ( experimental arm ) .", "sentence_id": 3}
+{"abstract_id": "25450879", "label": "methods", "text": "Treatment is repeated every @ weeks and for a maximum of @ courses .", "sentence_id": 4}
+{"abstract_id": "25450879", "label": "methods", "text": "Patients randomized to the experimental arm in the absence of disease progression after @ cycles continue bevacizumab alone until progression or for a maximum of @ courses .", "sentence_id": 5}
+{"abstract_id": "25450879", "label": "methods", "text": "Tumor assessment is done every @ cycles .", "sentence_id": 6}
+{"abstract_id": "25450879", "label": "methods", "text": "Major eligibility criteria are : age @ years ; histologically or cytologically documented extensive disease SCLC ; Eastern Cooperative Oncology Group performance status @ ; adequate hematological , hepatic and renal functions ; no history of grade @ or higher hemoptysis ; and no evidence of tumor cavitation .", "sentence_id": 7}
+{"abstract_id": "25450879", "label": "methods", "text": "The primary end point of this study is overall survival .", "sentence_id": 8}
+{"abstract_id": "25450879", "label": "methods", "text": "Secondary end points include response rate , time to progression , and toxicity .", "sentence_id": 9}
+{"abstract_id": "25450879", "label": "conclusions", "text": "An interim futility analysis was performed by an Independent Data Monitoring Committee in September @ and the trial obtained approval to continue .", "sentence_id": 10}
+{"abstract_id": "25450879", "label": "conclusions", "text": "As of July @ , @ , @ patients of @ planned have been randomized .", "sentence_id": 11}
+{"abstract_id": "25439055", "label": "background", "text": "Severe mental illness ( SMI ) , including schizophrenia , bipolar disorder and severe depression , is responsible for a substantial proportion of disability in the population .", "sentence_id": 0}
+{"abstract_id": "25439055", "label": "background", "text": "This article describes the aims and design of a research study that takes a novel approach to targeted prevention of SMI .", "sentence_id": 1}
+{"abstract_id": "25439055", "label": "background", "text": "It is based on the rationale that early developmental antecedents to SMI are likely to be more malleable than fully developed mood or psychotic disorders and that low-risk interventions targeting antecedents may reduce the risk of SMI .", "sentence_id": 2}
+{"abstract_id": "25439055", "label": "methods", "text": "Families Overcoming Risks and Building Opportunities for Well-being ( FORBOW ) is an accelerated cohort study that includes a large proportion of offspring of parents with SMI and embeds intervention trials in a cohort multiple randomized controlled trial ( cmRCT ) design .", "sentence_id": 3}
+{"abstract_id": "25439055", "label": "methods", "text": "Antecedents are conditions of the individual that are distressing but not severely impairing , predict SMI with moderate-to-large effect sizes and precede the onset of SMI by at least several years .", "sentence_id": 4}
+{"abstract_id": "25439055", "label": "methods", "text": "FORBOW focuses on the following antecedents : affective lability , anxiety , psychotic-like experiences , basic symptoms , sleep problems , somatic symptoms , cannabis use and cognitive delay .", "sentence_id": 5}
+{"abstract_id": "25439055", "label": "methods", "text": "Enrolment of offspring over a broad age range ( @ to @ years ) will allow researchers to draw conclusions on a longer developmental period from a study of shorter duration .", "sentence_id": 6}
+{"abstract_id": "25439055", "label": "methods", "text": "Annual assessments cover a full range of psychopathology , cognitive abilities , eligibility criteria for interventions and outcomes .", "sentence_id": 7}
+{"abstract_id": "25439055", "label": "methods", "text": "Pre-emptive early interventions ( PEI ) will include skill training for parents of younger children and courses in emotional well-being skills based on cognitive behavioural therapy for older children and youth .", "sentence_id": 8}
+{"abstract_id": "25439055", "label": "methods", "text": "A sample enriched for familial risk of SMI will enhance statistical power for testing the efficacy of PEI .", "sentence_id": 9}
+{"abstract_id": "25439055", "label": "conclusions", "text": "FORBOW offers a platform for efficient and unbiased testing of interventions selected according to best available evidence .", "sentence_id": 10}
+{"abstract_id": "25439055", "label": "conclusions", "text": "Since few differences exist between familial and ` sporadic ' SMI , the same interventions are likely to be effective in the general population .", "sentence_id": 11}
+{"abstract_id": "25439055", "label": "conclusions", "text": "Comparison of short-term efficacy of PEI on antecedents and the long term efficacy for preventing the onset of SMI will provide an experimental test of the etiological role of antecedents in the development of SMI .", "sentence_id": 12}
+{"abstract_id": "26267983", "label": "objective", "text": "To evaluate the effectiveness of naproxen @ mg taken orally @ minutes before , endometrial biopsy for pain relief during the procedure .", "sentence_id": 0}
+{"abstract_id": "26267983", "label": "methods", "text": "A double blind , randomized , placebo-controlled trial was conducted in @ patients with indication for endometrial biopsy at Ramathibodi Hospital between April @ and January @ .", "sentence_id": 1}
+{"abstract_id": "26267983", "label": "methods", "text": "The patients were randomly allocated into two groups to receive naproxen @ mg ( n = @ ) or placebo ( n = @ ) , @ minutes before endometrial biopsy .", "sentence_id": 2}
+{"abstract_id": "26267983", "label": "methods", "text": "Pain score was assessed using Visual Analogue Scale during and @ minutes after the procedure .", "sentence_id": 3}
+{"abstract_id": "26267983", "label": "methods", "text": "Adverse events were observed .", "sentence_id": 4}
+{"abstract_id": "26267983", "label": "results", "text": "The mean pain score during endometrial biopsy in the treatment group was significantly lower compared to the placebo group ( @ @ vs. @ @ , respectively , p-value < @ ) .", "sentence_id": 5}
+{"abstract_id": "26267983", "label": "results", "text": "However , the mean pain score at @ minutes after endometrial sampling were minimal and had non-statistical significance in both groups .", "sentence_id": 6}
+{"abstract_id": "26267983", "label": "results", "text": "( @ @ vs. @ @ , p-value @ ) .", "sentence_id": 7}
+{"abstract_id": "26267983", "label": "conclusions", "text": "Naproxen @ mg taken orally @ minutes before endometrial biopsy significantly reduce pain score during the procedure .", "sentence_id": 8}
+{"abstract_id": "24849439", "label": "objective", "text": "To investigate the effects of different anesthesia depth on stress response in elderly patients undergoing elective laparoscopic surgery for colorectal cancer .", "sentence_id": 0}
+{"abstract_id": "24849439", "label": "methods", "text": "A total of @ ASA I-III patients aged @-@ years undergoing elective laparoscopic surgery for colorectal cancer with general anesthesia were randomized into @ groups , namely group A with a target Narcotrend index ( NI ) maintained at D@ level , group B with a NI at D@ level , and group C with a NI at E@ level .", "sentence_id": 1}
+{"abstract_id": "24849439", "label": "methods", "text": "The anesthetics ( profopol and remifentanil ) were adjusted according to Narcotrend monitoring results to maintain the specified anesthesia depth .", "sentence_id": 2}
+{"abstract_id": "24849439", "label": "methods", "text": "The patients ' heart rate ( HR ) and mean artery pressure ( MAP ) were recorded before anesthesia ( T@ ) , before intubation ( T@ ) , immediately after intubation ( T@ ) , at @ min before pneumoperitoneum ( T@ ) , @ min after pneumoperitoneum ( T@ ) , at the end of the surgery ( T@ ) and extubation ( T@ ) .", "sentence_id": 3}
+{"abstract_id": "24849439", "label": "methods", "text": "Serum levels of cortisol , adrenocorticotropic hormone ( ACTH ) , endothelin-@ ( ET-@ ) , tumor necrosis factor - ( TNF - ) , interleukin-@ ( IL-@ ) and C-reactive protein ( CRP ) were measured by standard ELISA and radioimmunoassay before anesthesia ( Ta ) , at the end of the surgery ( Tb ) and @ day after the surgery ( Tc ) .", "sentence_id": 4}
+{"abstract_id": "24849439", "label": "results", "text": "HR and MAP in group A increased significantly at T@ , T@ , and T@ compared to those at T@ ( P < @ ) , and were higher than those in group B and group C ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24849439", "label": "results", "text": "The MAP in all the @ groups all decreased at T@ and T@ ( P < @ or P < @ ) , and was markedly lower in group C than in groups A and B ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24849439", "label": "results", "text": "The incidence of hypertension was significantly higher in group A than in groups B and C ( P < @ ) , while the incidence of hypotension was much higher in group C ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24849439", "label": "results", "text": "There were no obvious differences in serum levels of cortisol , ACTH , CRP , IL-@ , TNF-a , or ET-@ among the groups at Ta ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24849439", "label": "results", "text": "The serum levels of ACTH in the @ groups all significantly increased at Tb and Tc ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24849439", "label": "results", "text": "CRP , IL-@ and TNF-a levels in group A were increased at Tb and Tc ( P < @ or P < @ ) and significantly higher than those in groups B and C ( P < @ or P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24849439", "label": "results", "text": "Cortisol in groups A and B increased at Tb and Tc ( P < @ ) to a significantly higher level than that in group C ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24849439", "label": "results", "text": "ET-@ level in group C at Tb and Tc was lower than those in groups A and B ( P < @ or P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24849439", "label": "conclusions", "text": "Maintaining the anesthesia depth for a NI at the D@ and E@ level can both attenuate the stress response in elderly patients undergoing laparoscopic surgery for colorectal cancer , but the hemodynamic stability can be better at a D@ level .", "sentence_id": 13}
+{"abstract_id": "25156622", "label": "background", "text": "The study purpose was to analyze midterm outcomes in a prospective trial of alemtuzumab ( Alem ) versus rabbit anti-thymocyte globulin ( rATG ) induction in simultaneous pancreas-kidney transplantation ( SPKT ) .", "sentence_id": 0}
+{"abstract_id": "25156622", "label": "methods", "text": "From February @ to October @ , @ SPKTs ( @ portal-enteric drainage ) were prospectively randomized as part of a larger kidney transplant study to receive either single-dose Alem ( @ mg intraoperatively ) or multiple-dose rATG antibody induction ( starting intraoperatively , minimum three doses administered ) with tacrolimus/mycophenolate steroids .", "sentence_id": 1}
+{"abstract_id": "25156622", "label": "results", "text": "Of @ kidney transplant patients enrolled in the study , @ received SPKTs ; @ ( @ % ) received Alem and @ ( @ % ) rATG induction .", "sentence_id": 2}
+{"abstract_id": "25156622", "label": "results", "text": "Follow-up ranged from @ to @ months ( mean @ months ) .", "sentence_id": 3}
+{"abstract_id": "25156622", "label": "results", "text": "There were no significant differences between the two groups in @ years actual patient ( @ % Alem vs @ % rATG ) , kidney ( @ % Alem vs @ % rATG , p = @ ) or pancreas ( @ % Alem vs @ % rATG ) graft survival rates .", "sentence_id": 4}
+{"abstract_id": "25156622", "label": "results", "text": "Five years death-censored kidney ( @ % Alem vs @ % rATG , p = @ ) and pancreas ( @ % Alem vs @ % rATG , p = @ ) graft survival rates were slightly higher in patients receiving Alem .", "sentence_id": 5}
+{"abstract_id": "25156622", "label": "results", "text": "Acute rejection ( @ % Alem vs @ % rATG , p = @ ) and major infection ( @ % Alem vs @ % rATG , p = @ ) rates were slightly lower in the Alem group ; cytomegalovirus infections were significantly lower ( @ Alem vs @ % rATG , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25156622", "label": "results", "text": "The incidence of late acute rejection was low in both groups .", "sentence_id": 7}
+{"abstract_id": "25156622", "label": "results", "text": "There were no differences in early pancreas thrombosis ( @ % Alem vs @ % rATG ) , postoperative bleeding ( @ % Alem vs @ rATG ) , other surgical complications , readmissions or freedom from steroids between groups .", "sentence_id": 8}
+{"abstract_id": "25156622", "label": "results", "text": "In patients with functioning grafts , @ years mean serum creatinine ( @ Alem vs @ mg/dl rATG ) , calculated abbreviated modification of diet in renal disease glomerular filtration rate ( @ Alem vs @ ml/min/@ @ m ( @ ) rATG ) , hemoglobin A@c ( both @ % ) and C-peptide ( @ Alem vs @ ng/ml rATG ) levels were similar .", "sentence_id": 9}
+{"abstract_id": "25156622", "label": "conclusions", "text": "Single-dose Alem and multiple-dose rATG induction provide similar midterm patient survival and graft functional outcomes with no major differences in morbidity or resource utilization .", "sentence_id": 10}
+{"abstract_id": "25028655", "label": "background", "text": "The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and after Helicobacter pylori eradication .", "sentence_id": 0}
+{"abstract_id": "25028655", "label": "methods", "text": "First-degree relatives of gastric cancer patients underwent gastroscopy before and @ years after H. pylori eradication .", "sentence_id": 1}
+{"abstract_id": "25028655", "label": "methods", "text": "The morphological changes in two categories ( normal to mild and moderate to severe ) were compared with level of pepsinogens I and II before eradication ( n = @ ) , after eradication ( n = @ ) , and in those with persistent infection ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25028655", "label": "results", "text": "After eradication , pepsinogen I decreased to @ % and pepsinogen II to @ % of the previous values .", "sentence_id": 3}
+{"abstract_id": "25028655", "label": "results", "text": "Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups , pepsinogen I generally did not change .", "sentence_id": 4}
+{"abstract_id": "25028655", "label": "results", "text": "After eradication , subjects with high mononuclear infiltration in corpus had lower pepsinogen I ( @ versus @ / mL ) , higher pepsinogen II ( @ versus @ / mL ) , and lower ratio ( @ versus @ ) than those without ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25028655", "label": "conclusions", "text": "Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication .", "sentence_id": 6}
+{"abstract_id": "25046946", "label": "objective", "text": "To study the efficacy of Xiaoyao Powder ( XYP ) combined with interferon alpha ( IFN-alpha ) in treating HBeAg positive chronic hepatitis B ( CHB ) patients and the effect on their quality of life ( QOL ) .", "sentence_id": 0}
+{"abstract_id": "25046946", "label": "methods", "text": "Totally @ patients with HBeAg-positive CHB confirmed by liver biopsy were randomly assigned to @ groups , Group A ( @ cases ) and Group B ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "25046946", "label": "methods", "text": "IFN-alpha@b was subcutaneously injected to patients in Group A at the dose of @ microg , thrice per week .", "sentence_id": 2}
+{"abstract_id": "25046946", "label": "methods", "text": "Those in Group B additionally took XYP .", "sentence_id": 3}
+{"abstract_id": "25046946", "label": "methods", "text": "The therapeutic course for all was @ weeks .", "sentence_id": 4}
+{"abstract_id": "25046946", "label": "methods", "text": "Clinical efficacy was observed by assessing ALT restoration rate , HBeAg negative rate , HBeAg conversion rate , HBV DNA negative rate , complete response rate , partial response rate , and symptoms integral .", "sentence_id": 5}
+{"abstract_id": "25046946", "label": "methods", "text": "The evaluation of QOL was performed by using chronic liver disease questionnaire ( CLDQ ) score .", "sentence_id": 6}
+{"abstract_id": "25046946", "label": "methods", "text": "Adverse reaction occurrence rate was observed in the two groups .", "sentence_id": 7}
+{"abstract_id": "25046946", "label": "results", "text": "Better effects were obtained in Group A on ALT restoration rate , HBeAg negative rate , HBV DNA negative rate , complete response rate , partial response rate , TCM symptoms integral , the total effective rate of TCM sysmptoms , CLDQ score , and adverse reaction rates , showing statistical difference when compared with Group B ( P < @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25046946", "label": "conclusions", "text": "XYP could elevate the efficacy of TCM symptoms of HBeAg-positive CHB patients and anti-viral effect , improve their QOL , and reduce adverse reaction of IFN-alpha .", "sentence_id": 9}
+{"abstract_id": "24491642", "label": "objective", "text": "To evaluate long-term efficacy and safety profiles during @ years of individualized ranibizumab treatment in patients with visual impairment due to diabetic macular edema ( DME ) .", "sentence_id": 0}
+{"abstract_id": "24491642", "label": "methods", "text": "Phase IIIb , multicenter , @-month , randomized core study and @-month open-label extension study .", "sentence_id": 1}
+{"abstract_id": "24491642", "label": "methods", "text": "Of the @ patients who completed the randomized RESTORE @-month core study , @ entered the extension study .", "sentence_id": 2}
+{"abstract_id": "24491642", "label": "methods", "text": "In the extension study , patients were eligible to receive individualized ranibizumab treatment as of month @ guided by best-corrected visual acuity ( BCVA ) and disease progression criteria at the investigators ' discretion .", "sentence_id": 3}
+{"abstract_id": "24491642", "label": "methods", "text": "Concomitant laser treatment was allowed according to the Early Treatment Diabetic Retinopathy Study guidelines .", "sentence_id": 4}
+{"abstract_id": "24491642", "label": "methods", "text": "Based on the treatments received in the core study , the extension study groups were referred to as prior ranibizumab , prior ranibizumab + laser , and laser .", "sentence_id": 5}
+{"abstract_id": "24491642", "label": "methods", "text": "Change in BCVA and incidence of ocular and nonocular adverse events ( AEs ) over @ years .", "sentence_id": 6}
+{"abstract_id": "24491642", "label": "results", "text": "Overall , @ patients ( @ % ) completed the extension study .", "sentence_id": 7}
+{"abstract_id": "24491642", "label": "results", "text": "In patients treated with ranibizumab during the core study , consecutive individualized ranibizumab treatment during the extension study led to an overall maintenance of BCVA and central retinal subfield thickness ( CRST ) observed at month @ over the @-year extension study ( +@ letters , -@ m -LSB- prior ranibizumab -RSB- and +@ letters , -@ m -LSB- prior ranibizumab + laser -RSB- from baseline at month @ ) with a median of @ injections ( mean , @ injections ; prior ranibizumab ) and @ ( mean , @ injections ; prior ranibizumab + laser ) .", "sentence_id": 8}
+{"abstract_id": "24491642", "label": "results", "text": "In the prior laser group , a progressive BCVA improvement ( +@ letters ) and CRST reduction ( -@ m ) at month @ were observed after allowing ranibizumab during the extension study , with a median of @ injections ( mean , @ injections ) from months @ to @ .", "sentence_id": 9}
+{"abstract_id": "24491642", "label": "results", "text": "Patients in all @ treatment groups received a mean of < @ injections in the final year .", "sentence_id": 10}
+{"abstract_id": "24491642", "label": "results", "text": "No cases of endophthalmitis , retinal tear , or retinal detachment were reported .", "sentence_id": 11}
+{"abstract_id": "24491642", "label": "results", "text": "The most frequently reported ocular and nonocular adverse effects over @ years were cataract ( @ % ) and nasopharyngitis ( @ % ) .", "sentence_id": 12}
+{"abstract_id": "24491642", "label": "results", "text": "Eight deaths were reported during the extension study , but none were suspected to be related to the study drug/procedure .", "sentence_id": 13}
+{"abstract_id": "24491642", "label": "conclusions", "text": "Ranibizumab was effective in improving and maintaining BCVA and CRST outcomes with a progressively declining number of injections over @ years of individualized dosing .", "sentence_id": 14}
+{"abstract_id": "24491642", "label": "conclusions", "text": "Ranibizumab was generally well tolerated with no new safety concerns over @ years .", "sentence_id": 15}
+{"abstract_id": "24708851", "label": "background", "text": "Physical therapy treatment of patients with lymphedema includes treatment based on the principles of ` Complete Decongestive Therapy ' ( CDT ) .", "sentence_id": 0}
+{"abstract_id": "24708851", "label": "background", "text": "CDT consists of the following components ; skin care , manual lymphatic drainage , bandaging and exercises .", "sentence_id": 1}
+{"abstract_id": "24708851", "label": "background", "text": "The scientific evidence regarding what type of treatment is most effective is sparse .", "sentence_id": 2}
+{"abstract_id": "24708851", "label": "background", "text": "The objective of this study is to investigate whether CDT is equally effective if it includes manual lymphatic drainage or not in the treatment of arm lymphedema among patients with breast cancer .", "sentence_id": 3}
+{"abstract_id": "24708851", "label": "methods", "text": "A randomized , single-blind , equivalence trial .", "sentence_id": 4}
+{"abstract_id": "24708851", "label": "methods", "text": "A total of @ breast cancer patients with arm lymphedema will be recruited from @ hospitals and randomized into one of two treatment groups A : Complete Decongestive Therapy including manual drainage or B : Complete Decongestive Therapy without manual lymphatic drainage .", "sentence_id": 5}
+{"abstract_id": "24708851", "label": "methods", "text": "The intervention period will be approximately @ weeks followed by a @ month follow-up period ( @ months from baseline ) .", "sentence_id": 6}
+{"abstract_id": "24708851", "label": "methods", "text": "Primary outcome variable : the percentage volume reduction of lymphedema ( % ) from baseline to @ months .", "sentence_id": 7}
+{"abstract_id": "24708851", "label": "methods", "text": "Secondary outcome variables : Differences from baseline to week @ and from week @ to month @ in circumference of the arm ( cm ) , body weight ( kg ) , patient sensation of heaviness ( scale range : @-@ ) , patient sensation of tension ( scale range : @-@ ) , and quality of life ( EQ-@D-@ L-questionnaire ) .", "sentence_id": 8}
+{"abstract_id": "24708851", "label": "methods", "text": "All measurements are standardized and will be performed before randomization , after @ weeks and after @ months .", "sentence_id": 9}
+{"abstract_id": "24708851", "label": "conclusions", "text": "This randomized controlled study seeks to provide data on an effective treatment for patients with breast cancer related arm lymphedema and which at the same time causes minimal patient inconvenience .", "sentence_id": 10}
+{"abstract_id": "25134117", "label": "objective", "text": "To determine the effects of lipid based nutritional supplements with either whey or soy protein in patients with HIV during the first three months of antiretroviral treatment ( ART ) and to explore effects of timing by comparing supplementation at the start of ART and after three months delay .", "sentence_id": 0}
+{"abstract_id": "25134117", "label": "methods", "text": "Randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25134117", "label": "methods", "text": "Three public ART facilities in Jimma , Oromia region , Ethiopia .", "sentence_id": 2}
+{"abstract_id": "25134117", "label": "methods", "text": "Adults with HIV eligible for ART with body mass index ( BMI ) > @ .", "sentence_id": 3}
+{"abstract_id": "25134117", "label": "methods", "text": "Daily supplementation with @ g ( @ kJ ) of supplement containing whey or soy during either the first three or the subsequent three months of ART .", "sentence_id": 4}
+{"abstract_id": "25134117", "label": "methods", "text": "Primary : lean body mass assessed with deuterium dilution , grip strength measured with dynamometers , and physical activity measured with accelerometer and heart rate monitors .", "sentence_id": 5}
+{"abstract_id": "25134117", "label": "methods", "text": "Secondary : viral load and CD@ counts .", "sentence_id": 6}
+{"abstract_id": "25134117", "label": "methods", "text": "Auxiliary : weight and CD@ and CD@ counts .", "sentence_id": 7}
+{"abstract_id": "25134117", "label": "results", "text": "Of @ patients enrolled , @ ( @ % ) were women , mean age was @ ( SD @ ) , and mean BMI was @ ( SD @ ) .", "sentence_id": 8}
+{"abstract_id": "25134117", "label": "results", "text": "At three months , participants receiving the supplements containing whey or soy had increased their lean body mass by @ kg ( @ % confidence interval @ kg to @ kg ) and @ kg ( @ kg to @ kg ) , respectively , more than controls .", "sentence_id": 9}
+{"abstract_id": "25134117", "label": "results", "text": "This was accompanied by an increased gain of grip strength of @ kg ( -@ kg to @ kg ) for the whey supplement group and @ kg ( @ kg to @ kg ) for the soy supplement group .", "sentence_id": 10}
+{"abstract_id": "25134117", "label": "results", "text": "There were no effects on physical activity .", "sentence_id": 11}
+{"abstract_id": "25134117", "label": "results", "text": "Total weight gain increased by @ kg ( @ kg to @ kg ) and @ kg ( @ kg to @ kg ) for the whey and soy groups , respectively .", "sentence_id": 12}
+{"abstract_id": "25134117", "label": "results", "text": "In addition , in the whey supplement group overall CD@ counts improved by @ cells/L ( @ to @ cells/L ) , of which @ cells/L ( @ to @ cells/L ) were CD@ and @ cells/L ( -@ to @ cells/L ) were CD@ .", "sentence_id": 13}
+{"abstract_id": "25134117", "label": "results", "text": "Effects of the soy containing supplement on immune recovery were not significant .", "sentence_id": 14}
+{"abstract_id": "25134117", "label": "results", "text": "The effects of the two supplements , however , were not significantly different in direct comparison .", "sentence_id": 15}
+{"abstract_id": "25134117", "label": "results", "text": "Exploratory analysis showed that relatively more lean body mass was gained by patients with undetectable viral load at three months .", "sentence_id": 16}
+{"abstract_id": "25134117", "label": "results", "text": "Patients receiving delayed supplementation had higher weight gain but lower gains in functional outcomes .", "sentence_id": 17}
+{"abstract_id": "25134117", "label": "conclusions", "text": "Lipid based nutritional supplements improved gain of weight , lean body mass , and grip strength in patients with HIV starting ART .", "sentence_id": 18}
+{"abstract_id": "25134117", "label": "conclusions", "text": "Supplements containing whey were associated with improved immune recovery .", "sentence_id": 19}
+{"abstract_id": "25134117", "label": "conclusions", "text": "Trial registration Controlled-trials .", "sentence_id": 20}
+{"abstract_id": "25134117", "label": "conclusions", "text": "com ISRCTN@ .", "sentence_id": 21}
+{"abstract_id": "26141466", "label": "background", "text": "Daikenchuto ( DKT ) has widely been used to improve abdominal symptoms by being expected to accelerate bowel motility .", "sentence_id": 0}
+{"abstract_id": "26141466", "label": "background", "text": "The purpose of this study is to examine the efficacy and safety of DKT for prevention of ileus and associated gastrointestinal symptoms after total gastrectomy .", "sentence_id": 1}
+{"abstract_id": "26141466", "label": "methods", "text": "Two hundred and forty-five gastric cancer patients who underwent total gastrectomy were enrolled .", "sentence_id": 2}
+{"abstract_id": "26141466", "label": "methods", "text": "Patients received either DKT ( @ g/d ) or matching placebo from postoperative days @ to @ .", "sentence_id": 3}
+{"abstract_id": "26141466", "label": "methods", "text": "Primary end points were time to first flatus , time to first bowel movement ( BM ) , and frequency of BM .", "sentence_id": 4}
+{"abstract_id": "26141466", "label": "methods", "text": "Secondary end points included quality of life , C-reactive protein level , symptoms indicative of a severe gastrointestinal disorder , and incidence of postoperative ileus .", "sentence_id": 5}
+{"abstract_id": "26141466", "label": "results", "text": "A total of @ patients ( DKT , n = @ ; placebo , n = @ ) were included in the per-protocol set analysis .", "sentence_id": 6}
+{"abstract_id": "26141466", "label": "results", "text": "There were no significant differences between the groups in terms of patient background characteristics .", "sentence_id": 7}
+{"abstract_id": "26141466", "label": "results", "text": "Median time to first BM was shorter in the DKT group than in the placebo group ( @ hours vs @ hours ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "26141466", "label": "results", "text": "In patients with high medication adherence , median time to first BM was significantly shorter in the DKT group than in the placebo group ( @ hours vs @ hours ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "26141466", "label": "results", "text": "Significantly fewer patients in the DKT group had @ symptoms of gastrointestinal dysfunction than those in the placebo group on postoperative day @ ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "26141466", "label": "conclusions", "text": "Administration of DKT during the immediate postoperative period after total gastrectomy appears to promote early recovery of postoperative bowel function .", "sentence_id": 11}
+{"abstract_id": "25098260", "label": "objective", "text": "To determine the effects of Ginkgo biloba extract ( EGB ) on major periodontal pathogens in subgingival plaque .", "sentence_id": 0}
+{"abstract_id": "25098260", "label": "methods", "text": "Sixty patients with moderate to severe periodontitis were selected and randomly assigned to @ groups : EGB group , a positive ( periocline ) and a negative control groups .", "sentence_id": 1}
+{"abstract_id": "25098260", "label": "methods", "text": "Subgingival plaque samples were collected before treatment and @ week , @ months and @ months after treatment .", "sentence_id": 2}
+{"abstract_id": "25098260", "label": "methods", "text": "The detection rates of @ major periodontal pathogens-Treponema denticola ( Td ) , Tannerella forsythus ( Tf ) , Prevotella intermedia ( Pi ) , and Porphyromonas gingivalis ( Pg ) - were detected by polymerase chain reaction ( PCR ) .", "sentence_id": 3}
+{"abstract_id": "25098260", "label": "methods", "text": "Clinical indicators were examined before treatment , @ and @ months after treatment .", "sentence_id": 4}
+{"abstract_id": "25098260", "label": "results", "text": "EGB significantly decreased the detection rate of all the @ pathogens @ week after treatment , and then gradually increased at @ and @ months .", "sentence_id": 5}
+{"abstract_id": "25098260", "label": "results", "text": "EGB 's inhibition effect was better than or comparable to periocline , except for Pg in short-term .", "sentence_id": 6}
+{"abstract_id": "25098260", "label": "results", "text": "The difference of plaque index ( PLI ) and bleeding index ( BI ) was not statistically significant among the groups , while for probing depth ( PD ) and attachment loss ( AL ) , the difference was statistically significant between the EGB group and negative control group at @ and @ months after treatment .", "sentence_id": 7}
+{"abstract_id": "25098260", "label": "conclusions", "text": "EGB significantly inhibited major periodontal pathogens and can be used as an adjuvant for periodontitis treatment .", "sentence_id": 8}
+{"abstract_id": "25785695", "label": "objective", "text": "Instructional methods for the simple suture technique vary widely and are seldom based on educational research .", "sentence_id": 0}
+{"abstract_id": "25785695", "label": "objective", "text": "Published data indicate that video primers and structured instruction and evaluation decrease learning time and improve skill acquisition .", "sentence_id": 1}
+{"abstract_id": "25785695", "label": "objective", "text": "To determine the amount of practice needed to attain simple suture proficiency and to identify the optimal teaching schedule for retention of skill .", "sentence_id": 2}
+{"abstract_id": "25785695", "label": "methods", "text": "First-year and second-year medical students at the Icahn School of Medicine at Mount Sinai with little to no suturing experience were randomly divided into @ equal groups , with one being taught on day @ and tested for proficiency on day @ ( control group ) and the other being taught on day @ and tested for proficiency on days @ , @ , and @ ( experimental group ) .", "sentence_id": 3}
+{"abstract_id": "25785695", "label": "methods", "text": "Students were evaluated using the objective structured assessment of technical skills method and a checklist .", "sentence_id": 4}
+{"abstract_id": "25785695", "label": "methods", "text": "Those initially not proficient on a given day were immediately prompted to practice and retest .", "sentence_id": 5}
+{"abstract_id": "25785695", "label": "methods", "text": "This cycle continued until proficiency was achieved for that day .", "sentence_id": 6}
+{"abstract_id": "25785695", "label": "methods", "text": "The study was conducted from April @ , @ , to June @ , @ .", "sentence_id": 7}
+{"abstract_id": "25785695", "label": "methods", "text": "Simple suture proficiency at @ days and the mean number of practice sutures needed for proficiency on day @ .", "sentence_id": 8}
+{"abstract_id": "25785695", "label": "results", "text": "All students ultimately achieved proficiency .", "sentence_id": 9}
+{"abstract_id": "25785695", "label": "results", "text": "The mean ( SD ) number of practice sutures required to achieve proficiency at the initial training was @ ( @ ) .", "sentence_id": 10}
+{"abstract_id": "25785695", "label": "results", "text": "Students in the control group had a @ % pass rate at the @-day initial proficiency test , while students in the experimental group had a @ % pass rate at day @ ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25785695", "label": "results", "text": "There were no differences in instructional time , cumulative number of sutures , or objective structured assessment of technical skills scores at proficiency between groups across the study .", "sentence_id": 12}
+{"abstract_id": "25785695", "label": "conclusions", "text": "Single instructional sessions may not be sufficient to maintain simple suture proficiency over the course of a @-day elective .", "sentence_id": 13}
+{"abstract_id": "25785695", "label": "conclusions", "text": "We propose the use of preparatory instructional videos , followed by instructor demonstration to introduce the technique .", "sentence_id": 14}
+{"abstract_id": "25785695", "label": "conclusions", "text": "Independent practice with intermittent evaluation and critique allows for skill acquisition and time efficiency at the initial training .", "sentence_id": 15}
+{"abstract_id": "25785695", "label": "conclusions", "text": "Students should view instructional videos and practice at least @ repetitions every @ days to maintain their skill .", "sentence_id": 16}
+{"abstract_id": "24392703", "label": "objective", "text": "There have been no studies of the effect of continuous positive airway pressure ( CPAP ) therapy on erectile dysfunction ( ED ) and serum testosterone in men with type @ diabetes and obstructive sleep apnoea ( OSA ) , a patient group at increased risk of ED and hypogonadism .", "sentence_id": 0}
+{"abstract_id": "24392703", "label": "objective", "text": "The aim of this study was to determine whether CPAP improves sexual and gonadal function in males with type @ diabetes and a pre-CPAP apnoea-hypopnoea index > @/h .", "sentence_id": 1}
+{"abstract_id": "24392703", "label": "methods", "text": "Substudy of a trial assessing the effect of @ months of CPAP on cardiovascular risk in type @ diabetes .", "sentence_id": 2}
+{"abstract_id": "24392703", "label": "methods", "text": "Of @ males starting CPAP , @ ( mean SD age @ @ years , median -LSB- interquartile range -RSB- diabetes duration @ -LSB- @-@ @ -RSB- years ) completed the trial .", "sentence_id": 3}
+{"abstract_id": "24392703", "label": "methods", "text": "Serum total and free testosterone , responses to the Androgen Deficiency in the Aging Aale ( ADAM ) and Sexual Health Inventory for Men ( SHIM ) questionnaires .", "sentence_id": 4}
+{"abstract_id": "24392703", "label": "results", "text": "There were no significant changes in mean total or free testosterone ( baseline concentrations @ @ nm and @ @ pm , respectively ) , or SHIM score ( baseline @ -LSB- @-@ -RSB- ) , after @ months of CPAP ( P > @ ) .", "sentence_id": 5}
+{"abstract_id": "24392703", "label": "results", "text": "The ADAM score ( baseline @ @ ) fell after @ month ( to @ @ ) and was maintained at this level at @ months ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24392703", "label": "results", "text": "The Epworth Sleepiness Scale score decreased and self-reported physical activity increased over @ months ( P @ ) without a change in body mass index ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24392703", "label": "conclusions", "text": "These findings imply that CPAP therapy improves somnolence and promotes exercise in men with type @ diabetes , but that there is no direct benefit for gonadal or sexual function .", "sentence_id": 8}
+{"abstract_id": "24823461", "label": "background", "text": "GH treatment significantly increased adult height ( AH ) in a dose-dependent manner in short non-GH-deficient children in a randomized , controlled , clinical trial ; the mean gain in height SD score ( heightSDS ) was @ ( range @-@ ) , compared with @ in the untreated group .", "sentence_id": 0}
+{"abstract_id": "24823461", "label": "objective", "text": "The objective of the study was to analyze the relationship between IGF-@SDS , IGF binding protein-@ SDS ( IGFBP@SDS ) , and their ratioSDS with a gain in the heightSDS until AH in non-GH-deficient short children .", "sentence_id": 1}
+{"abstract_id": "24823461", "label": "methods", "text": "This was a randomized , controlled , multicenter clinical trial .", "sentence_id": 2}
+{"abstract_id": "24823461", "label": "methods", "text": "The intervention included GH treatment : @ or @ g/kg d plus untreated controls .", "sentence_id": 3}
+{"abstract_id": "24823461", "label": "methods", "text": "One hundred fifty-one non-GH-deficient short children were included in the intent-to-treat ( ITT ) population and @ in the per-protocol ( PP ) population ; @ children in the ITT and @ children in the PP populations had idiopathic short stature ( ISS ) .", "sentence_id": 4}
+{"abstract_id": "24823461", "label": "methods", "text": "Increments from baseline to on-treatment study mean IGF-@SDS ( IGF-@SDS ) , IGFBP@SDS , and IGF-@ to IGFBP@ ratioSDS were assessed in relationship to the gain in heightSDS .", "sentence_id": 5}
+{"abstract_id": "24823461", "label": "results", "text": "Sixty-two percent of the variance in the gain in heightSDS in children on GH treatment could be explained by four variables : IGF-@SDS ( explaining @ % ) , bone age delay , birth length ( the taller the better ) , and GH dose ( the higher the better ) .", "sentence_id": 6}
+{"abstract_id": "24823461", "label": "results", "text": "The lower IGF-@SDS was at baseline , the higher was its increment during treatment .", "sentence_id": 7}
+{"abstract_id": "24823461", "label": "results", "text": "For both the AllPP - and the ISSPP-treated groups , the attained IGF-@SDS study level did not correlate with height gain .", "sentence_id": 8}
+{"abstract_id": "24823461", "label": "conclusions", "text": "In short non-GH-deficient children , the GH dose-related increment in IGF-@SDS from baseline to mean study level was the most important explanatory variable for long-term growth response from the peripubertal period until AH , when IGF-@SDS , IGFBP@SDS , and their ratioSDS were compared concurrently .", "sentence_id": 9}
+{"abstract_id": "24679247", "label": "objective", "text": "The aim of the study was to compare intermittent ( IAD ) and continuous ( CAD ) androgen deprivation therapy ( ADT ) between locally advanced ( M@ ) and metastatic ( M@ ) prostate cancer , and the effect of ADT on the quality of life .", "sentence_id": 0}
+{"abstract_id": "24679247", "label": "methods", "text": "In total , @ men with advanced prostate cancer were enrolled to receive goserelin acetate for @ weeks .", "sentence_id": 1}
+{"abstract_id": "24679247", "label": "methods", "text": "Of these , @ patients whose prostate-specific antigen ( PSA ) decreased to less than @ ng/ml or by at least @ % ( < @ ng/ml at baseline ) were randomized to IAD or CAD .", "sentence_id": 2}
+{"abstract_id": "24679247", "label": "methods", "text": "In the IAD arm , ADT was resumed for at least @ weeks whenever PSA increased to greater than @ ng/ml or above baseline .", "sentence_id": 3}
+{"abstract_id": "24679247", "label": "results", "text": "Median follow-up time was @ months .", "sentence_id": 4}
+{"abstract_id": "24679247", "label": "results", "text": "Median times from randomization to progression , death , prostate cancer death and treatment failure in M@ and M@ patients were @ and @ , @ and @ , @ and @ , and @ and @ months , respectively ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24679247", "label": "results", "text": "No significant differences emerged between IAD and CAD .", "sentence_id": 6}
+{"abstract_id": "24679247", "label": "results", "text": "ADT showed a beneficial effect on pain , activity limitation and social functioning in M@ patients , and a deleterious effect on physical capacity in M@ patients and on sexual functioning in both groups .", "sentence_id": 7}
+{"abstract_id": "24679247", "label": "results", "text": "IAD offered extra benefit for activity limitation , social functioning and recovery of sexual functioning .", "sentence_id": 8}
+{"abstract_id": "24679247", "label": "conclusions", "text": "IAD is as efficient as CAD in treatment of locally advanced and metastatic prostate cancer .", "sentence_id": 9}
+{"abstract_id": "24679247", "label": "conclusions", "text": "ADT improves quality of life in M@ patients , with IAD offering extra benefit .", "sentence_id": 10}
+{"abstract_id": "24382782", "label": "background", "text": "Recombinant interleukin-@ ( rIL-@ ) induces cellular cytotoxicity against leukemia blasts .", "sentence_id": 0}
+{"abstract_id": "24382782", "label": "background", "text": "Patients with acute myeloid leukemia ( AML ) in first complete remission ( CR ) may harbor minimal residual disease that is susceptible to rIL-@-activated effector cells .", "sentence_id": 1}
+{"abstract_id": "24382782", "label": "methods", "text": "In the Cancer and Leukemia Group B ( CALGB ) @ study , patients with AML in first CR were randomly assigned after all planned chemotherapy to receive a @-day course of subcutaneously administered rIL-@ or no further therapy .", "sentence_id": 2}
+{"abstract_id": "24382782", "label": "methods", "text": "The primary objective was to compare disease-free survival ( DFS ) between the @ treatment arms .", "sentence_id": 3}
+{"abstract_id": "24382782", "label": "methods", "text": "A total of @ patients achieved a CR , @ of whom were randomized .", "sentence_id": 4}
+{"abstract_id": "24382782", "label": "methods", "text": "Six courses of low-dose daily rIL-@ were given for the expansion of cytotoxic effector cells , each followed by @-day high-dose boluses given to trigger cytotoxicity against minimal residual disease .", "sentence_id": 5}
+{"abstract_id": "24382782", "label": "results", "text": "On the protocol-specified intention-to-treat analysis , the hazards ratio for DFS was @ ( @ % confidence interval , @-@ @ ; P = @ ) ; the @-year DFS rate was @ % in the observation arm and @ % in the rIL-@ treatment arm .", "sentence_id": 6}
+{"abstract_id": "24382782", "label": "results", "text": "The hazards ratio for overall survival ( OS ) was @ ( @ % confidence interval , @-@ @ ; P = @ ) ; the @-year OS rate was @ % for the observation arm and @ % for the rIL-@ treatment arm .", "sentence_id": 7}
+{"abstract_id": "24382782", "label": "results", "text": "Twenty-five of the @ patients randomized to treatment with rIL-@ either refused or were unable to initiate therapy and @ patients did not complete their assigned therapy .", "sentence_id": 8}
+{"abstract_id": "24382782", "label": "results", "text": "However , significant toxicities were not commonly observed .", "sentence_id": 9}
+{"abstract_id": "24382782", "label": "results", "text": "The trial design did not anticipate the difficulties patients would encounter with protocol compliance .", "sentence_id": 10}
+{"abstract_id": "24382782", "label": "conclusions", "text": "The efficacy of immunotherapy with rIL-@ administered after intensive postremission treatment was not assessed as planned because of unexpected refusals by patients and/or their physicians to comply with protocol-directed therapy .", "sentence_id": 11}
+{"abstract_id": "24382782", "label": "conclusions", "text": "Neither DFS nor OS was found to be significantly improved .", "sentence_id": 12}
+{"abstract_id": "24673675", "label": "objective", "text": "Older patients discharged from the emergency department ( ED ) have difficulty comprehending discharge plans and are at high risk of adverse outcomes .", "sentence_id": 0}
+{"abstract_id": "24673675", "label": "objective", "text": "The authors investigated whether a postdischarge telephone call-mediated intervention by a nurse would improve discharge care plan adherence , specifically by expediting post-ED visit physician follow-up appointments and/or compliance with medication changes .", "sentence_id": 1}
+{"abstract_id": "24673675", "label": "objective", "text": "The second objectives were to determine if this telephone call intervention would reduce return ED visits and/or hospitalizations within @days of the index ED visit and to determine potential cost savings of this intervention .", "sentence_id": 2}
+{"abstract_id": "24673675", "label": "methods", "text": "This was a @-week randomized , controlled trial among patients aged @ and older discharged to home from an academic ED .", "sentence_id": 3}
+{"abstract_id": "24673675", "label": "methods", "text": "At @ to @days after each patient 's index ED visit , a trained nurse called intervention group patients to review discharge instructions and assist with discharge plan compliance ; placebo call group patients received a patient satisfaction survey call , while the control group patients were not called .", "sentence_id": 4}
+{"abstract_id": "24673675", "label": "methods", "text": "Data collection calls occurred at @ to @days and @ to @days after the index ED visits for all three groups .", "sentence_id": 5}
+{"abstract_id": "24673675", "label": "methods", "text": "Chi-square or Fisher 's exact tests were performed for categorical data and the Kruskal-Wallis test examined group differences in time to follow-up .", "sentence_id": 6}
+{"abstract_id": "24673675", "label": "results", "text": "A total of @ patients completed the study .", "sentence_id": 7}
+{"abstract_id": "24673675", "label": "results", "text": "Patients were @ % female and @ % white , with a mean age of @years ( standard deviation -LSB- SD -RSB- @ years ) .", "sentence_id": 8}
+{"abstract_id": "24673675", "label": "results", "text": "Intervention patients were more likely to follow up with medical providers within @days of their ED visits than either the placebo or the control group patients ( @ , @ , and @ % , respectively ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24673675", "label": "results", "text": "All groups performed well in medication acquisition and comprehension of medication indications and dosage .", "sentence_id": 10}
+{"abstract_id": "24673675", "label": "results", "text": "There were no differences in return visits to the ED or hospital within @days of the index ED visit for intervention patients , compared to placebo or control group patients ( @ , @ , and @ % , respectively ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24673675", "label": "results", "text": "An economic analysis showed an estimated @ % chance that this intervention would reduce total costs .", "sentence_id": 12}
+{"abstract_id": "24673675", "label": "conclusions", "text": "Telephone call follow-up of older patients discharged from the ED resulted in expedited follow-up for patients with their primary care physicians .", "sentence_id": 13}
+{"abstract_id": "24673675", "label": "conclusions", "text": "Further study is warranted to determine if these results translate into improved patient outcomes , decreased return ED visits or hospital admissions , and cost savings resulting from this intervention .", "sentence_id": 14}
+{"abstract_id": "24397584", "label": "objective", "text": "To compare characteristics of hypoglycemic episodes in patients with type @ diabetes receiving saxagliptin or glipizide add-on therapy to metformin .", "sentence_id": 0}
+{"abstract_id": "24397584", "label": "methods", "text": "This was a post hoc analysis of an international , randomized , parallel-group , double-blind , active-controlled , phase @ trial .", "sentence_id": 1}
+{"abstract_id": "24397584", "label": "methods", "text": "The @-week trial and @-week extension were conducted from December @ to August @ .", "sentence_id": 2}
+{"abstract_id": "24397584", "label": "methods", "text": "Patients aged @ years with glycated hemoglobin ( HbA@c ) > @ % to @ % receiving stable metformin doses ( @mg/d ) were randomized @:@ to add-on therapy with saxagliptin @mg/d or glipizide @ to @mg/d ( titrated to optimal effect or highest tolerable dose during the initial @ weeks ) .", "sentence_id": 3}
+{"abstract_id": "24397584", "label": "methods", "text": "Hypoglycemic episodes were recorded in patient diaries .", "sentence_id": 4}
+{"abstract_id": "24397584", "label": "methods", "text": "Confirmed hypoglycemic events were defined as fingerstick glucose @mg/dL ( @ mmol/L ) with associated symptoms .", "sentence_id": 5}
+{"abstract_id": "24397584", "label": "results", "text": "Of @ patients randomized , @ received saxagliptin + metformin , and @ received glipizide + metformin .", "sentence_id": 6}
+{"abstract_id": "24397584", "label": "results", "text": "Saxagliptin was noninferior to glipizide in lowering HbA@c .", "sentence_id": 7}
+{"abstract_id": "24397584", "label": "results", "text": "Hypoglycemia with saxagliptin + metformin and glipizide + metformin was reported by @ ( @ events ) and @ ( @ events ) patients , respectively , through week @ .", "sentence_id": 8}
+{"abstract_id": "24397584", "label": "results", "text": "The mean ( SD ) number of hypoglycemic events per patient reporting hypoglycemia was lower with saxagliptin + metformin versus glipizide + metformin through weeks @ ( @ -LSB- SD @ -RSB- vs @ -LSB- SD @ -RSB- , respectively ) and @ ( @ -LSB- SD @ -RSB- vs @ -LSB- SD @ -RSB- ) .", "sentence_id": 9}
+{"abstract_id": "24397584", "label": "results", "text": "Most patients receiving glipizide + metformin with hypoglycemia had multiple events ( @/@ patients -LSB- @ % -RSB- ) .", "sentence_id": 10}
+{"abstract_id": "24397584", "label": "results", "text": "Confirmed hypoglycemia , major events , and severe events occurred only with glipizide + metformin .", "sentence_id": 11}
+{"abstract_id": "24397584", "label": "results", "text": "Time to first hypoglycemic event was shorter with glipizide versus saxagliptin .", "sentence_id": 12}
+{"abstract_id": "24397584", "label": "results", "text": "Limitations of this analysis include its post hoc nature , a high rate of study discontinuation , and exclusion of patients with serious comorbidities and complications .", "sentence_id": 13}
+{"abstract_id": "24397584", "label": "conclusions", "text": "Saxagliptin + metformin was associated with fewer patients reporting hypoglycemia and fewer and less severe hypoglycemic events in those experiencing hypoglycemia compared with glipizide + metformin .", "sentence_id": 14}
+{"abstract_id": "24397584", "label": "conclusions", "text": "ClinicalTrials.gov registration number : NCT@ .", "sentence_id": 15}
+{"abstract_id": "24745013", "label": "background", "text": "This study is a comparative evaluation of the TVT , TOT , and our own modification of TOT ( mTOT ) in the treatment of female stress urinary incontinence from a single center experience .", "sentence_id": 0}
+{"abstract_id": "24745013", "label": "methods", "text": "The study was conducted on @ patients with SUI diagnosed on the basis of urodynamic studies .", "sentence_id": 1}
+{"abstract_id": "24745013", "label": "methods", "text": "They were divided into three groups -- TVT : n = @ , ( TOT ) : n = @ , and mTOT : n = @ .", "sentence_id": 2}
+{"abstract_id": "24745013", "label": "methods", "text": "All of the patients underwent evaluation at @ , @ , and @ months after surgery .", "sentence_id": 3}
+{"abstract_id": "24745013", "label": "methods", "text": "Results were statistically analysed and compared .", "sentence_id": 4}
+{"abstract_id": "24745013", "label": "results", "text": "Objective and subjective effectiveness after the surgery were not significantly different in the study groups and ranged from @ % to @ % .", "sentence_id": 5}
+{"abstract_id": "24745013", "label": "results", "text": "Mean surgery time was @ , @ , and @ in the TVT , TOT , and mTOT , respectively .", "sentence_id": 6}
+{"abstract_id": "24745013", "label": "results", "text": "Mean hospitalization time was @ days .", "sentence_id": 7}
+{"abstract_id": "24745013", "label": "results", "text": "Mean catheter maintenance time was significantly higher in the TVT than in other groups .", "sentence_id": 8}
+{"abstract_id": "24745013", "label": "results", "text": "In the TVT group total incidence of complications was @ % , and it was significantly higher than that in TOT and mTOT ( @ % and @ % , resp . )", "sentence_id": 9}
+{"abstract_id": "24745013", "label": "conclusions", "text": "TVT , TOT , and mTOT are highly effective and safe methods in the treatment of SUI .", "sentence_id": 10}
+{"abstract_id": "24745013", "label": "conclusions", "text": "There are no differences in the efficacy between the methods with a little higher percentage of complications in the TVT group .", "sentence_id": 11}
+{"abstract_id": "24376252", "label": "objective", "text": "The Lower Mississippi Delta ( LMD ) region of the United States is characterized by high levels of obesity and physical inactivity .", "sentence_id": 0}
+{"abstract_id": "24376252", "label": "objective", "text": "The objective was to test the effectiveness of adapting the @ Dietary Guidelines for Americans ( DG ) , with and without a physical activity ( PA ) component , for attenuating weight gain .", "sentence_id": 1}
+{"abstract_id": "24376252", "label": "methods", "text": "Overall , @ white and African-American adults ( @-@ years ; body mass index @-@ @ kg/m ( @ ) ) were randomized to a DG only group ( n = @ ) or a DG + PA group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24376252", "label": "methods", "text": "Both groups received a @-week dietary education and behavior change intervention .", "sentence_id": 3}
+{"abstract_id": "24376252", "label": "methods", "text": "The DG + PA group also received PA education and a pedometer .", "sentence_id": 4}
+{"abstract_id": "24376252", "label": "methods", "text": "Changes in weight ( kg ) , % weight , and waist circumference ( WC ; cm ) were determined .", "sentence_id": 5}
+{"abstract_id": "24376252", "label": "methods", "text": "Analyses considered all completers ( n = @ ) and those who engaged with @ % of the intervention ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24376252", "label": "methods", "text": "General linear models compared mean changes between groups after adjustment for baseline values , race , and sex .", "sentence_id": 7}
+{"abstract_id": "24376252", "label": "results", "text": "Weight , % weight , and WC significantly decreased from baseline to follow-up in both groups ( p < @ ; unadjusted values ) .", "sentence_id": 8}
+{"abstract_id": "24376252", "label": "results", "text": "Adjusted analysis showed a main effect of group for weight ( p = @ ) and % weight ( p = @ ) in the completers analysis , and WC ( p = @ ) in the @ % attendance analysis , with the DG + PA group improving weight-related outcomes more .", "sentence_id": 9}
+{"abstract_id": "24376252", "label": "conclusions", "text": "Low-burden behavioral interventions could be effective strategies in attenuating unhealthy weight gain in the LMD .", "sentence_id": 10}
+{"abstract_id": "25283680", "label": "objective", "text": "The goal of the present research was the examination of overlap between @ research traditions on interpersonal personality traits in major depression .", "sentence_id": 0}
+{"abstract_id": "25283680", "label": "objective", "text": "We hypothesized that Blatt 's ( @ ) dimensions of depressive experiences around the dimensions of relatedness ( i.e. , dependency ) and self-definition ( i.e. , self-criticism ) are associated with specific interpersonal problems according to the interpersonal circumplex model ( Leary , @ ) .", "sentence_id": 1}
+{"abstract_id": "25283680", "label": "objective", "text": "In addition , we examined correlations of interpersonal characteristics with depression severity .", "sentence_id": 2}
+{"abstract_id": "25283680", "label": "methods", "text": "Analyses were conducted on @ patients with major depressive disorder combined from @ samples .", "sentence_id": 3}
+{"abstract_id": "25283680", "label": "methods", "text": "Of the patients , @ participated in a randomized controlled trial in the United States , and @ patients were recruited in an inpatient unit in Germany .", "sentence_id": 4}
+{"abstract_id": "25283680", "label": "methods", "text": "Patients completed measures of symptomatic distress , interpersonal problems , and depressive experiences .", "sentence_id": 5}
+{"abstract_id": "25283680", "label": "results", "text": "Dependency was associated with more interpersonal problems related to low dominance and high affiliation , while self-criticism was associated with more interpersonal problems related to low affiliation .", "sentence_id": 6}
+{"abstract_id": "25283680", "label": "results", "text": "These associations were independent of depression severity .", "sentence_id": 7}
+{"abstract_id": "25283680", "label": "results", "text": "Self-criticism showed high overlap with cognitive symptoms of depression .", "sentence_id": 8}
+{"abstract_id": "25283680", "label": "conclusions", "text": "The findings support the interpersonal nature of Blatt 's dimensions of depressive experiences .", "sentence_id": 9}
+{"abstract_id": "25283680", "label": "conclusions", "text": "Self-criticism is associated with being too distant or cold toward others as well as greater depression severity , but is not related to the dimension of dominance .", "sentence_id": 10}
+{"abstract_id": "25458200", "label": "background", "text": "Long-term macrolide treatment has proven benefit in inflammatory airways diseases , but whether it leads to changes in the composition of respiratory microbiota is unknown .", "sentence_id": 0}
+{"abstract_id": "25458200", "label": "background", "text": "We aimed to assess whether long-term , low-dose erythromycin treatment changes the composition of respiratory microbiota in people with non-cystic fibrosis bronchiectasis .", "sentence_id": 1}
+{"abstract_id": "25458200", "label": "methods", "text": "Microbiota composition was determined by @S rRNA gene sequencing of sputum samples from participants in the BLESS trial , a @-month , double-blind , placebo-controlled trial of twice-daily erythromycin ethylsuccinate ( @ mg ) in adult patients with non-cystic fibrosis bronchiectasis and at least two infective exacerbations in the preceding year .", "sentence_id": 2}
+{"abstract_id": "25458200", "label": "methods", "text": "The primary outcome was within-patient change in respiratory microbiota composition ( assessed by Bray-Curtis index ) between baseline and week @ , comparing erythromycin with placebo .", "sentence_id": 3}
+{"abstract_id": "25458200", "label": "methods", "text": "The BLESS trial is registered with the Australian New Zealand Clinical Trials Registry , number ACTRN@ .", "sentence_id": 4}
+{"abstract_id": "25458200", "label": "results", "text": "The BLESS trial took place between Oct @ , @ , and Dec @ , @ .", "sentence_id": 5}
+{"abstract_id": "25458200", "label": "results", "text": "Paired sputum samples were available from @ randomly assigned patients , @ in the placebo group and @ in the erythromycin group .", "sentence_id": 6}
+{"abstract_id": "25458200", "label": "results", "text": "The change in microbiota composition between baseline and week @ was significantly greater with erythromycin than with placebo ( median Bray-Curtis score @ -LSB- IQR @-@ -RSB- vs @ -LSB- @-@ -RSB- ; median difference @ , @ % CI @-@ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25458200", "label": "results", "text": "In patients with baseline airway infection dominated by Pseudomonas aeruginosa , erythromycin did not change microbiota composition significantly .", "sentence_id": 8}
+{"abstract_id": "25458200", "label": "results", "text": "In those with infection dominated by organisms other than P. aeruginosa , erythromycin caused a significant change in microbiota composition ( p = @ -LSB- by analysis of similarity -RSB- ) , representing a reduced relative abundance of Haemophilus influenzae ( @ % -LSB- @-@ -RSB- vs @ % -LSB- @-@ -RSB- ; median difference @ % , @ % CI @-@ ; p = @ ; interaction p = @ ) and an increased relative abundance of P aeruginosa ( @ % -LSB- @-@ -RSB- vs @ % -LSB- @-@ -RSB- ; median difference @ % , @ % CI @-@ ; p = @ ; interaction p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25458200", "label": "results", "text": "Compared with placebo , erythromycin reduced the rate of pulmonary exacerbations over the @ weeks of the study in patients with P. aeruginosa-dominated infection ( median @ -LSB- IQR @-@ -RSB- vs @ -LSB- @-@ -RSB- ; median difference -@ , @ % CI -@ to -@ ; p = @ ) , but not in those without P. aeruginosa-dominated infection ( @ -LSB- @-@ -RSB- vs @ -LSB- @-@ -RSB- ; median difference @ , -@ to @ ; p = @ ; interaction p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25458200", "label": "conclusions", "text": "Long-term erythromycin treatment changes the composition of respiratory microbiota in patients with bronchiectasis .", "sentence_id": 11}
+{"abstract_id": "25458200", "label": "conclusions", "text": "In patients without P. aeruginosa airway infection , erythromycin did not significantly reduce exacerbations and promoted displacement of H. influenzae by more macrolide-tolerant pathogens including P. aeruginosa .", "sentence_id": 12}
+{"abstract_id": "25458200", "label": "conclusions", "text": "These findings argue for a cautious approach to chronic macrolide use in patients without P. aeruginosa airway infection .", "sentence_id": 13}
+{"abstract_id": "25277789", "label": "objective", "text": "To evaluate whether a combination of misoprostol and oxytocin more effectively reduces blood loss during and after cesarean delivery than does oxytocin alone among women with known risk factors for postpartum hemorrhage ( PPH ) .", "sentence_id": 0}
+{"abstract_id": "25277789", "label": "methods", "text": "A prospective , randomized , double-blind , placebo-controlled trial was performed at a tertiary care center in Kolkata , India , between October @ and December @ .", "sentence_id": 1}
+{"abstract_id": "25277789", "label": "methods", "text": "Women were eligible if they were undergoing emergency cesarean under spinal anesthesia and were at high risk for PPH .", "sentence_id": 2}
+{"abstract_id": "25277789", "label": "methods", "text": "Participants were randomly assigned ( @:@ ) to receive @ g misoprostol or matched placebo sublingually after delivery of the newborn using a computer-generated random number sequence ( block size eight ) .", "sentence_id": 3}
+{"abstract_id": "25277789", "label": "methods", "text": "Participants and providers were masked to assignment .", "sentence_id": 4}
+{"abstract_id": "25277789", "label": "methods", "text": "All participants received @ IU oxytocin .", "sentence_id": 5}
+{"abstract_id": "25277789", "label": "methods", "text": "The primary outcomes were intraoperative and postoperative blood loss .", "sentence_id": 6}
+{"abstract_id": "25277789", "label": "results", "text": "Both groups contained @ women .", "sentence_id": 7}
+{"abstract_id": "25277789", "label": "results", "text": "Mean intraoperative blood loss was significantly lower in the misoprostol group ( @ mL ) than in the placebo group ( @ mL ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25277789", "label": "results", "text": "Mean postoperative blood loss was slightly lower in the misoprostol group ( @ mL ) than in the placebo group ( @ mL ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25277789", "label": "results", "text": "Shivering and pyrexia were more frequently associated with misoprostol ( P < @ for both ) .", "sentence_id": 10}
+{"abstract_id": "25277789", "label": "conclusions", "text": "Misoprostol as an adjunct to oxytocin seemed to more effectively reduce blood loss than did oxytocin alone .", "sentence_id": 11}
+{"abstract_id": "25277789", "label": "conclusions", "text": "Clinical Trial Registry India : CTRI/@/@ / @ .", "sentence_id": 12}
+{"abstract_id": "24621800", "label": "objective", "text": "This study aimed to assess cost-effectiveness of N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) - guided versus symptom-guided therapy in heart failure ( HF ) patients@ years old .", "sentence_id": 0}
+{"abstract_id": "24621800", "label": "background", "text": "Cost-effectiveness of NT-proBNP guidance in HF patients is unclear .", "sentence_id": 1}
+{"abstract_id": "24621800", "label": "background", "text": "It may create additional costs with uncertain benefits .", "sentence_id": 2}
+{"abstract_id": "24621800", "label": "methods", "text": "In the TIME-CHF ( Trial of Intensified versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure ) , patients with left ventricular ejection fraction ( LVEF ) of@ % were randomized to receive intensified NT-proBNP-guided therapy or standard , symptom-guided therapy .", "sentence_id": 3}
+{"abstract_id": "24621800", "label": "methods", "text": "For cost-effectiveness analysis , @ ( @ % ) patients ( age @ @ years , @ % male ) were eligible .", "sentence_id": 4}
+{"abstract_id": "24621800", "label": "methods", "text": "Incremental cost-effectiveness was calculated as incremental costs per gained life-year and quality-adjusted life-year ( QALY ) within the @-month trial period , as defined per protocol .", "sentence_id": 5}
+{"abstract_id": "24621800", "label": "results", "text": "NT-proBNP-guided therapy was dominant ( i.e. , more effective and less costly ) over symptom-guided therapy , saving $ @,@ USD ( @ to @ % confidence interval -LSB- CI -RSB- : $ @,@ to $ @,@ ) per patient , with incremental effectiveness of +@ life-years and +@ QALYs .", "sentence_id": 6}
+{"abstract_id": "24621800", "label": "results", "text": "The probability of NT-proBNP-guided therapy being dominant was @ % , and the probability of saving @ life-year or QALY at a cost of $ @,@ was @ % and @ % , respectively .", "sentence_id": 7}
+{"abstract_id": "24621800", "label": "results", "text": "Exclusion of residence costs resulted in an incremental cost-effectiveness ratio ( ICER ) of $ @,@ per life-year gained .", "sentence_id": 8}
+{"abstract_id": "24621800", "label": "results", "text": "Cost-effectiveness of NT-proBNP-guided therapy was most pronounced in patients < @ years old and in those with < @significant comorbidities , being dominant in all sensitivity analyses .", "sentence_id": 9}
+{"abstract_id": "24621800", "label": "results", "text": "In the worst-case scenario ( excluding residence costs in those with@ comorbidities ) , the ICER was $ @,@ per life-year gained .", "sentence_id": 10}
+{"abstract_id": "24621800", "label": "conclusions", "text": "NT-proBNP-guided therapy has a high probability of being cost effective in HF patients with reduced LVEF , particularly in patients age @ to @ years or with less than @ comorbidities .", "sentence_id": 11}
+{"abstract_id": "24621800", "label": "conclusions", "text": "( Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure -LSB- TIME-CHF -RSB- ; ISRCTN@ ) .", "sentence_id": 12}
+{"abstract_id": "25110231", "label": "background", "text": "Functional magnetic resonance imaging ( fMRI ) studies involving alcohol challenge are important for identifying neural correlates of alcohol 's psychopharmacological effects .", "sentence_id": 0}
+{"abstract_id": "25110231", "label": "background", "text": "However , evaluating acute alcohol effects on blood oxygen level-dependent ( BOLD ) signal change is complicated by alcohol-related increases in cerebral blood flow ( CBF ) .", "sentence_id": 1}
+{"abstract_id": "25110231", "label": "objective", "text": "The present study aimed to further characterize acute alcohol effects on CBF using intravenous alcohol administration to maximize control over brain alcohol exposure .", "sentence_id": 2}
+{"abstract_id": "25110231", "label": "methods", "text": "Twenty heavy-drinking young adults ( M = @ years old , SD = @ ) completed alcohol and placebo imaging sessions in a within-subject , counter-balanced , placebo-controlled design .", "sentence_id": 3}
+{"abstract_id": "25110231", "label": "methods", "text": "Arterial spin labeling ( ASL ) provided estimates of perfusion change at two target blood alcohol concentrations ( @ and @ mg % ) relative to baseline and relative to a saline control infusion .", "sentence_id": 4}
+{"abstract_id": "25110231", "label": "results", "text": "Voxel-wise analyses showed widespread and dose-dependent effects of alcohol on CBF increase .", "sentence_id": 5}
+{"abstract_id": "25110231", "label": "results", "text": "Region-of-interest analyses confirmed these findings , also indicating regional variation in the magnitude of perfusion change .", "sentence_id": 6}
+{"abstract_id": "25110231", "label": "results", "text": "Additional findings indicated that lower self-reported sensitivity to alcohol corresponded with reduced perfusion change during alcohol administration .", "sentence_id": 7}
+{"abstract_id": "25110231", "label": "conclusions", "text": "This study provides further evidence for widespread effects of acute alcohol on cerebral perfusion , also demonstrating regional , dose-dependent , and inter-individual variation .", "sentence_id": 8}
+{"abstract_id": "25110231", "label": "conclusions", "text": "Further research is needed to evaluate implications of these effects for the design and interpretation of pharmacological fMRI studies involving alcohol challenge .", "sentence_id": 9}
+{"abstract_id": "25098195", "label": "methods", "text": "Feasibility randomized controlled trial .", "sentence_id": 0}
+{"abstract_id": "25098195", "label": "objective", "text": "To assess the feasibility of a trial to investigate the effectiveness of a lumbopelvic monitor as a feedback device for modifying postural behavior during daily work-related activities .", "sentence_id": 1}
+{"abstract_id": "25098195", "label": "background", "text": "Frequent or sustained flexed postures play a role in the development or maintenance of nonspecific low back pain .", "sentence_id": 2}
+{"abstract_id": "25098195", "label": "background", "text": "The provision of postural feedback could help individuals with or at risk of nonspecific low back pain improve their postural awareness and avoid hazardous or pain-provoking postures .", "sentence_id": 3}
+{"abstract_id": "25098195", "label": "methods", "text": "Sixty-two participants employed in a health care organization were randomly allocated into @ of @ groups : a control group , an intermittent feedback group , and a constant feedback group .", "sentence_id": 4}
+{"abstract_id": "25098195", "label": "methods", "text": "Adherence and follow-up rates were assessed .", "sentence_id": 5}
+{"abstract_id": "25098195", "label": "methods", "text": "Differences in postural pattern between baseline and follow-up measurements were used to assess the effectiveness of the lumbopelvic monitor as a postural feedback device .", "sentence_id": 6}
+{"abstract_id": "25098195", "label": "results", "text": "Adherence was approximately @ % .", "sentence_id": 7}
+{"abstract_id": "25098195", "label": "results", "text": "With the exception of @ center , the follow-up overall rates exceeded the a priori desired threshold of @ % .", "sentence_id": 8}
+{"abstract_id": "25098195", "label": "results", "text": "Within-group comparisons revealed no significant differences in postural pattern for the control group and intermittent feedback group .", "sentence_id": 9}
+{"abstract_id": "25098195", "label": "results", "text": "The constant feedback group showed a significant reduction in flexed posture at the follow-up period compared with the baseline period .", "sentence_id": 10}
+{"abstract_id": "25098195", "label": "results", "text": "Differences between groups did not reach statistical significance ; however , the constant feedback group , compared with the control group , demonstrated an effect size ( d ) of @ .", "sentence_id": 11}
+{"abstract_id": "25098195", "label": "conclusions", "text": "The provision of constant postural feedback seems promising for promoting changes in postural behavior .", "sentence_id": 12}
+{"abstract_id": "25098195", "label": "conclusions", "text": "This feasibility trial identified adherence and follow-up rates and sample-size estimates important to the conduct of a fully powered efficacy trial .", "sentence_id": 13}
+{"abstract_id": "25098195", "label": "conclusions", "text": "Level of Evidence Therapy , level @b - .", "sentence_id": 14}
+{"abstract_id": "25271117", "label": "objective", "text": "To evaluate basal and prandial insulin initiation and titration in people with type @ diabetes mellitus ( T@DM ) in primary care and to explore the feasibility of retrospective-continuous glucose monitoring ( r-CGM ) in guiding insulin dosing .", "sentence_id": 0}
+{"abstract_id": "25271117", "label": "objective", "text": "The new model of care features General Practitioners ( GPs ) and Practice Nurses ( PNs ) working in an expanded role , with Credentialed Diabetes Educator - Registered Nurse ( CDE-RN ) support .", "sentence_id": 1}
+{"abstract_id": "25271117", "label": "methods", "text": "Insulin-nave T@DM patients ( HbA@c > @ % -LSB- > @ mmol/mol -RSB- despite maximal oral therapy ) from @ general practices in Victoria , Australia commenced insulin glargine , with glulisine added as required .", "sentence_id": 2}
+{"abstract_id": "25271117", "label": "methods", "text": "Each was randomised to receive r-CGM or self-monitoring of blood glucose ( SMBG ) .", "sentence_id": 3}
+{"abstract_id": "25271117", "label": "methods", "text": "Glycaemic control ( HbA@c ) was benchmarked against specialist ambulatory patients referred for insulin initiation .", "sentence_id": 4}
+{"abstract_id": "25271117", "label": "results", "text": "Ninety-two patients mean age ( range ) @ ( @-@ ) years ; @ % female ; mean ( SD ) diabetes duration @ ( @ ) years participated .", "sentence_id": 5}
+{"abstract_id": "25271117", "label": "results", "text": "HbA@c decreased from ( median ( IQR ) ) @ ( @ , @ ) % ; @ ( @ , @ ) mmol/mol to @ ( @ , @ ) % ; @ ( @ , @ ) mmol/mol at @ weeks ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25271117", "label": "results", "text": "Comparing r-CGM ( n = @ ) with SMBG ( n = @ ) , there were no differences in major hypoglycaemia ( p = @ ) or HbA@c ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25271117", "label": "results", "text": "More r-CGM than SMBG participants commenced glulisine ( @/@ vs. @/@ ; p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25271117", "label": "results", "text": "Results were comparable to @ benchmark patients , with similar low rates of major hypoglycaemia ( @/@ vs. @/@ ; p = @ ) and less loss to follow up in the INITIATION group ( @/@ vs. @/@ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25271117", "label": "conclusions", "text": "Insulin initiation and titration for T@DM patients in primary care was safe and improved HbA@c with low rates of major hypoglycaemia .", "sentence_id": 10}
+{"abstract_id": "25271117", "label": "conclusions", "text": "CDE-RNs were effective in a new consultant role .", "sentence_id": 11}
+{"abstract_id": "25271117", "label": "conclusions", "text": "r-CGM use in primary care was feasible and enhanced post-prandial hyperglycaemia recognition .", "sentence_id": 12}
+{"abstract_id": "25271117", "label": "conclusions", "text": "Trial registration ACTRN@ .", "sentence_id": 13}
+{"abstract_id": "25006854", "label": "background", "text": "Platelet-rich plasma ( PRP ) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition .", "sentence_id": 0}
+{"abstract_id": "25006854", "label": "background", "text": "Skin needling is a technique that uses a sterile dermaroller to puncture the skin and release growth factors .", "sentence_id": 1}
+{"abstract_id": "25006854", "label": "background", "text": "The combination of skin needling and PRP could enhance the efficacy of both modalities .", "sentence_id": 2}
+{"abstract_id": "25006854", "label": "background", "text": "Chemical reconstruction of skin scars technique consists of focal application of high concentration of trichloroacetic acid ( TCA ) on the acne scars to stimulate collagen production .", "sentence_id": 3}
+{"abstract_id": "25006854", "label": "objective", "text": "To evaluate the efficacy and safety of intradermal injection of PRP , @ % focal TCA , and combined skin needling plus topical PRP in the treatment of atrophic acne scars .", "sentence_id": 4}
+{"abstract_id": "25006854", "label": "methods", "text": "Forty-five patients with atrophic acne scars were randomly assigned to @ equal groups ; Group A received intradermal injection of PRP , Group B received chemical reconstruction of skin scars technique with TCA @ % , and Group C was treated by combined skin needling and PRP .", "sentence_id": 5}
+{"abstract_id": "25006854", "label": "methods", "text": "Each patient underwent @ sessions at @-week interval .", "sentence_id": 6}
+{"abstract_id": "25006854", "label": "results", "text": "All the patients completed the study .", "sentence_id": 7}
+{"abstract_id": "25006854", "label": "results", "text": "The @ groups showed statistically highly significant improvement in the degree of acne scars after treatment ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "25006854", "label": "results", "text": "No major adverse effects were observed in the studied groups .", "sentence_id": 9}
+{"abstract_id": "25006854", "label": "conclusions", "text": "This is the first study to use intradermal injection of PRP alone for the treatment of atrophic acne scars .", "sentence_id": 10}
+{"abstract_id": "25006854", "label": "conclusions", "text": "The @ modalities showed a promising efficacy and safety in the treatment of atrophic acne scars .", "sentence_id": 11}
+{"abstract_id": "25704790", "label": "background", "text": "While the addition of targeted therapy to neoadjuvant chemotherapy ( NACT ) dramatically increases the rate of pathological complete response in HER@-positive breast cancer , no reduction in the rate of mastectomy has been observed in randomised studies .", "sentence_id": 0}
+{"abstract_id": "25704790", "label": "methods", "text": "A retrospective single centre analysis of all patients treated with anti HER@-based NACT for T@-@ breast cancer , focusing on patients treated with mastectomy .", "sentence_id": 1}
+{"abstract_id": "25704790", "label": "results", "text": "Among @ patients treated between June @ and July @ , surgery was performed immediately post-NACT in @ cases ( @ % ) .", "sentence_id": 2}
+{"abstract_id": "25704790", "label": "results", "text": "Breast-conserving surgery could be performed for @ of the patients ( @ % ) , with a @-year local relapse-free survival of @ % .", "sentence_id": 3}
+{"abstract_id": "25704790", "label": "results", "text": "A mastectomy was performed in two cases following patients ' wishes and in @ cases based on pre-NACT findings ( n = @ ) or post-NACT outcomes ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25704790", "label": "results", "text": "For @ out of the @ cases , a good pathological response was observed , and multidisciplinary reanalysis suggests that breast-conserving surgery outright may have been sufficient for @ patients .", "sentence_id": 5}
+{"abstract_id": "25704790", "label": "results", "text": "Finally , a salvage mastectomy based on post-lumpectomy pathological results was decided in five cases ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25704790", "label": "results", "text": "The @-year metastasis-free survival was @ % for all patients operated on after NACT ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "25704790", "label": "conclusions", "text": "Given the good efficacy of anti HER@-based NACT , breast-conserving surgery should be standard practice for most patients .", "sentence_id": 8}
+{"abstract_id": "25704790", "label": "conclusions", "text": "Total mastectomy on the other hand should be restricted to a few patients , mainly those with positive margins on the lumpectomy specimen .", "sentence_id": 9}
+{"abstract_id": "24973609", "label": "objective", "text": "To investigate the @-year efficacy and safety of photorefractive keratectomy ( PRK ) .", "sentence_id": 0}
+{"abstract_id": "24973609", "label": "methods", "text": "Long-term observational case series .", "sentence_id": 1}
+{"abstract_id": "24973609", "label": "methods", "text": "In the setting of a university hospital , a study population of @ patients ( @ eyes ) who had , as part of a randomized prospective trial , undergone PRK @ years previously were studied .", "sentence_id": 2}
+{"abstract_id": "24973609", "label": "methods", "text": "All had received -@ or -@ diopter ( D ) corrections with either @ or @ mm optical zones or a multizone treatment .", "sentence_id": 3}
+{"abstract_id": "24973609", "label": "methods", "text": "The mean preoperative spherical equivalent refractive error ( SEQ ) was -@ D ( range , -@ to -@ D ) .", "sentence_id": 4}
+{"abstract_id": "24973609", "label": "methods", "text": "The outcome measures included visual acuity , refractive error , corneal topography and axial length .", "sentence_id": 5}
+{"abstract_id": "24973609", "label": "results", "text": "Between @ and @ years there was an increase in mean myopic SEQ of -@ D ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24973609", "label": "results", "text": "In patients younger than @ years of age at time of correction , this increase was -@ D ( P < @ ) with an accompanying increase in variance ( P < @ ) , whereas in those older than @ it was -@ D ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24973609", "label": "results", "text": "In female patients the change was -@ D ( P < @ ) , while in males it was -@ D ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24973609", "label": "results", "text": "The efficacy index at @ years was @ , and the safety index was @ .", "sentence_id": 9}
+{"abstract_id": "24973609", "label": "results", "text": "Corrected distance visual acuity improved between @ and @ years ( P < @ ) ; @ % of corneas were clear at @ years ; @ eyes had trace haze .", "sentence_id": 10}
+{"abstract_id": "24973609", "label": "results", "text": "There was an improvement in haze scores between @ and @ years ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24973609", "label": "results", "text": "Cornea power remained unchanged between @ months and @ years ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24973609", "label": "results", "text": "Axial length increased by a mean of @ mm ( P < @ ) .", "sentence_id": 13}
+{"abstract_id": "24973609", "label": "results", "text": "There was no ectasia .", "sentence_id": 14}
+{"abstract_id": "24973609", "label": "conclusions", "text": "There was a slight but significant increase in myopic SEQ after PRK between @ and @ years , particularly in those under @ at the time of treatment and in female patients .", "sentence_id": 15}
+{"abstract_id": "24973609", "label": "conclusions", "text": "Corneal power remained unchanged , but axial length increased .", "sentence_id": 16}
+{"abstract_id": "24973609", "label": "conclusions", "text": "The procedure was safe , with no long-term sight-threatening complications and with improvements in corrected distance visual acuity and corneal transparency with time .", "sentence_id": 17}
+{"abstract_id": "24275838", "label": "objective", "text": "We investigated data in @ patients from the EXPLOR trial to determine the influence of heart rate ( HR ) and blood pressure ( BP ) on aortic stiffness in response to beta-blockade or angiotensin @ type @ receptor antagonism , administered during @ weeks .", "sentence_id": 0}
+{"abstract_id": "24275838", "label": "methods", "text": "Carotid-femoral pulse wave velocity ( PWV ) was measured with aplanation tonometry ( Sphygmocor ) after @ ( W@ ) and @ weeks ( W@ ) of treatment by the single-pill combination valsartan-amlodipine ( @/@ mg , then @/@ mg ) or an atenolol-amlodipine combination ( @/@ mg , then @/@ mg ) in a prospective , randomized , parallel-groups multicenter trial with PROBE design .", "sentence_id": 1}
+{"abstract_id": "24275838", "label": "methods", "text": "Drugs were up-titrated at W@ .", "sentence_id": 2}
+{"abstract_id": "24275838", "label": "methods", "text": "We analyzed the changes in PWV in relation with the changes in BP and HR , and major covariates , using mixed models in each treatment arm .", "sentence_id": 3}
+{"abstract_id": "24275838", "label": "results", "text": "The unadjusted reductions in mean BP and PWV were not significantly different between groups .", "sentence_id": 4}
+{"abstract_id": "24275838", "label": "results", "text": "HR was significantly reduced in the atenolol group , but not in the valsartan group .", "sentence_id": 5}
+{"abstract_id": "24275838", "label": "results", "text": "After adjustment on BP and HR , PWV significantly decreased with valsartan -LSB- -@ m/s ( -@ to -@ ) at W@ and -@ ( -@ to -@ ) m/s at W@ -RSB- , whereas no significant change was observed after atenolol -LSB- -@ m/s ( -@ to @ ) at W@ and -@ ( -@ to @ ) m/s at W@ -RSB- .", "sentence_id": 6}
+{"abstract_id": "24275838", "label": "conclusions", "text": "These findings suggest that the reduction in PWV observed after atenolol could be explained by changes in BP and HR , whereas in patients treated by valsartan , about half of the decrease in aortic stiffness was BP-independent .", "sentence_id": 7}
+{"abstract_id": "24837447", "label": "objective", "text": "To evaluate the efficacy of daily low-dose sildenafil for the treatment of nonulcer interstitial cystitis ( IC ) in women .", "sentence_id": 0}
+{"abstract_id": "24837447", "label": "methods", "text": "Forty-eight women with a clinical diagnosis of IC from @ medical centers were randomly assigned to treatment with daily low-dose sildenafil ( @ mg , n = @ ) or placebo ( n = @ ) for @ months .", "sentence_id": 1}
+{"abstract_id": "24837447", "label": "methods", "text": "The O'Leary-Sant IC symptom and problem indices , visual analog scale scores , and a micturition diary with the interval of micturition , the frequency of nocturia , and urgency episodes were recorded before treatment , every @ weeks after the treatment until @ months .", "sentence_id": 2}
+{"abstract_id": "24837447", "label": "methods", "text": "Patient Overall Rating of Improvement in Symptoms was assessed and regarded as effective when the value was above @ % .", "sentence_id": 3}
+{"abstract_id": "24837447", "label": "results", "text": "The IC symptom and problem indices scores and urodynamic index were significantly improved in sildenafil treatment group as compared with placebo group and baselines at week @ , @ , @ , @ , and @ , as well as @ months after treatment ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24837447", "label": "results", "text": "Urodynamic index including first desire to void , strong desire to void , and maximum cystometric capacity was significantly improved in sildenafil treatment group at week @ and at @ months after treatment ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24837447", "label": "results", "text": "The efficiency of treatment reached @ % .", "sentence_id": 6}
+{"abstract_id": "24837447", "label": "results", "text": "However , no significant change of the visual analog scale values was observed between @ groups except at week @ in the sildenafil treatment group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24837447", "label": "results", "text": "All adverse events were mild to moderate and transient .", "sentence_id": 8}
+{"abstract_id": "24837447", "label": "conclusions", "text": "Daily low-dose sildenafil is an easy , well-tolerated , and effective treatment for IC in women .", "sentence_id": 9}
+{"abstract_id": "25620452", "label": "objective", "text": "Girls in the child welfare system are at high risk of revictimization in adolescence .", "sentence_id": 0}
+{"abstract_id": "25620452", "label": "objective", "text": "The present study compared two interventions designed to decrease revictimization in a diverse sample of adolescent child welfare-involved girls .", "sentence_id": 1}
+{"abstract_id": "25620452", "label": "objective", "text": "The social learning/feminist ( SL/F ) intervention focused on concepts derived from social learning and feminist models of risk , such as sexism and beliefs about relationships .", "sentence_id": 2}
+{"abstract_id": "25620452", "label": "objective", "text": "The risk detection/executive function ( RD/EF ) intervention focused on development of specific executive function abilities related to detecting and responding to risky situations/people .", "sentence_id": 3}
+{"abstract_id": "25620452", "label": "methods", "text": "Participants were randomized to RD/EF ( n = @ ) or SL/F intervention ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25620452", "label": "methods", "text": "A group of youth ( n = @ ) engaged in the research assessments only .", "sentence_id": 5}
+{"abstract_id": "25620452", "label": "methods", "text": "Participants ( n = @ ) were assessed before intervention , immediately after intervention , @ months after intervention , and @ months after intervention .", "sentence_id": 6}
+{"abstract_id": "25620452", "label": "methods", "text": "We examined revictimization ( the presence/absence of sexual or physical assault in any relationship ) over time .", "sentence_id": 7}
+{"abstract_id": "25620452", "label": "results", "text": "Adolescent girls in the RD/EF condition were nearly five times less likely to report sexual revictimization compared with girls in the no-treatment group .", "sentence_id": 8}
+{"abstract_id": "25620452", "label": "results", "text": "A trend suggested that girls who participated in the SL/F intervention were @ times less likely to report sexual revictimization relative to the no-treatment group .", "sentence_id": 9}
+{"abstract_id": "25620452", "label": "results", "text": "For physical revictimization , the odds of not being physically revictimized were three times greater in the SL/F condition and two times greater in the RD/EF condition compared with the no-treatment group .", "sentence_id": 10}
+{"abstract_id": "25620452", "label": "conclusions", "text": "The active interventions did not differ significantly from one another in rates of revictimization , suggesting that practitioners have at least two viable options to engage high-risk youth in revictimization prevention .", "sentence_id": 11}
+{"abstract_id": "24760248", "label": "objective", "text": "To investigate whether magnesium oxide reduces the interfraction motion of the prostate and the amount of rectal filling and rectal gas , which influences prostate position during radiotherapy for prostate cancer .", "sentence_id": 0}
+{"abstract_id": "24760248", "label": "methods", "text": "From December @ to February @ , @ prostate cancer patients scheduled for intensity-modulated radiotherapy ( @ Gy in @ fractions ) using fiducial marker-based position verification were randomly assigned to receive magnesium oxide ( @ mg twice a day ) or placebo during radiotherapy .", "sentence_id": 1}
+{"abstract_id": "24760248", "label": "methods", "text": "In a previous study , we investigated the effect on intrafraction motion and did not find a difference between the treatment arms .", "sentence_id": 2}
+{"abstract_id": "24760248", "label": "methods", "text": "Here , we compared the interfraction prostate motion between the two treatment arms as well as the amount of rectal filling and rectal air pockets using pretreatment planning computed tomography and magnetic resonance imagingscans .", "sentence_id": 3}
+{"abstract_id": "24760248", "label": "results", "text": "There was no statistically significant difference between the treatment arms in translation and rotation of the prostate between treatment fractions , except for the rotation around the cranial caudal axis .", "sentence_id": 4}
+{"abstract_id": "24760248", "label": "results", "text": "However , the difference was less than @ and therefore considered not clinically relevant .", "sentence_id": 5}
+{"abstract_id": "24760248", "label": "results", "text": "There was no significant difference in the amount of rectal filling and rectal air pockets between the treatment arms .", "sentence_id": 6}
+{"abstract_id": "24760248", "label": "conclusions", "text": "Magnesium oxide is not effective in reducing the interfraction prostate motion or the amount of rectal filling and rectal gas during external-beam radiotherapy .", "sentence_id": 7}
+{"abstract_id": "24760248", "label": "conclusions", "text": "Therefore , magnesium oxide is not recommended in clinical practice for these purposes .", "sentence_id": 8}
+{"abstract_id": "24597620", "label": "background", "text": "The primary aim of rheumatoid arthritis ( RA ) treatment is to induce remission , the absence of disease activity .", "sentence_id": 0}
+{"abstract_id": "24597620", "label": "background", "text": "The objective of this study was to explore the association between clinical endpoints used to gauge RA treatment efficacy and patient-reported outcomes of health-related quality of life , fatigue , and physical function in RA patients treated with secukinumab in a phase @ randomized controlled trial ( RCT ) .", "sentence_id": 1}
+{"abstract_id": "24597620", "label": "methods", "text": "Adult RA patients ( n = @ ) with incomplete responses to methotrexate were randomized equally to receive monthly s.c. injections of secukinumab @mg , @mg , @mg , @mg or placebo .", "sentence_id": 2}
+{"abstract_id": "24597620", "label": "methods", "text": "Clinical endpoints used in this study included the ACR response criteria and its components and simplified disease activity score .", "sentence_id": 3}
+{"abstract_id": "24597620", "label": "methods", "text": "Patient-reported outcomes ( PRO ) included Health Assessment Questionnaire-Disability Index ( HAQ-DI ) , Medical Outcomes Study Short Form-@ -LSB- SF-@ -RSB- Survey , and Functional Assessment of Chronic Illness Therapy-Fatigue ( FACIT-Fatigue ) .", "sentence_id": 4}
+{"abstract_id": "24597620", "label": "methods", "text": "Patients were categorized into mutually exclusive groups according to the magnitude and direction of change from baseline to week @ in each clinical endpoint .", "sentence_id": 5}
+{"abstract_id": "24597620", "label": "methods", "text": "Definitions of minimal important differences -LSB- MID -RSB- in each clinical endpoint were used to categorize patients , as well as thresholds beyond MID .", "sentence_id": 6}
+{"abstract_id": "24597620", "label": "methods", "text": "Mean changes from baseline to week @ were computed for each PRO and analyses of variance to test the differences in PRO changes observed across groups of patients that differed in each clinical endpoint .", "sentence_id": 7}
+{"abstract_id": "24597620", "label": "methods", "text": "Analyses were limited to patients randomized to secukinumab treatment .", "sentence_id": 8}
+{"abstract_id": "24597620", "label": "methods", "text": "All dose groups were combined ( n = @ ) .", "sentence_id": 9}
+{"abstract_id": "24597620", "label": "results", "text": "Mean changes from baseline in each PRO differed significantly across groups of patients in the expected direction .", "sentence_id": 10}
+{"abstract_id": "24597620", "label": "results", "text": "With few exceptions , there was considerable agreement between clinical endpoints and PROs concerning the magnitude of change defined as clinically meaningful .", "sentence_id": 11}
+{"abstract_id": "24597620", "label": "results", "text": "More importantly , results demonstrated that greater improvements in clinical endpoints were associated with incrementally better improvements in HRQoL , fatigue , and physical function .", "sentence_id": 12}
+{"abstract_id": "24597620", "label": "conclusions", "text": "Results of this study show considerable agreement between minimal thresholds of improvement established for PROs and clinical outcome measures used in RA treatment studies and provide thresholds to be considered in gauging the importance of a treatment effect that goes beyond what is considered as minimally important for PRO measures .", "sentence_id": 13}
+{"abstract_id": "24438500", "label": "background", "text": "Computed tomography is widely used to diagnose acute appendicitis .", "sentence_id": 0}
+{"abstract_id": "24438500", "label": "background", "text": "Many adolescents and young adults are exposed to the associated radiation .", "sentence_id": 1}
+{"abstract_id": "24438500", "label": "background", "text": "A recent single-institution trial has reported promising results for low-dose computed tomography ; however , this technique has not yet been widely adopted .", "sentence_id": 2}
+{"abstract_id": "24438500", "label": "background", "text": "LOCAT ( low-dose computed tomography for appendicitis trial ) , a multi-institution randomized controlled non-inferiority trial , aims to compare low-dose computed tomography and standard-dose computed tomography as the first-line imaging tests for adolescents and young adults , and therefore to test the generalizability of the previous single-institution trial results .", "sentence_id": 3}
+{"abstract_id": "24438500", "label": "methods", "text": "Participants with suspected appendicitis are randomly assigned to either the low-dose group ( with a typical effective dose of @mSv ) or the standard-dose group ( as used in normal practice at each participating site , typically @mSv ) .", "sentence_id": 4}
+{"abstract_id": "24438500", "label": "methods", "text": "The primary end point is the negative appendectomy rate ( the percentage of the number of uninflamed appendices that were removed among all non-incidental appendectomies ) , which is a consequence of false-positive diagnoses , with a non-inferiority margin of @ percentage points .", "sentence_id": 5}
+{"abstract_id": "24438500", "label": "methods", "text": "The key secondary end point is the appendiceal perforation rate , which is a consequence of delayed ( or false-negative ) diagnoses .", "sentence_id": 6}
+{"abstract_id": "24438500", "label": "methods", "text": "Participant recruitment will be continued until the number of non-incidental appendectomies for each group exceeds @ .", "sentence_id": 7}
+{"abstract_id": "24438500", "label": "methods", "text": "The total number of expected participants approximates @,@ , including those not undergoing appendectomy .", "sentence_id": 8}
+{"abstract_id": "24438500", "label": "conclusions", "text": "In addition to the study protocol , we elaborate on several challenging or potentially debatable components of the study design , including the broad eligibility criteria , choice of the primary end point , potential effect of using advanced imaging techniques on study results , determining and adjusting the radiation doses , ambiguities in reference standards , rationale for the non-inferiority margin , use of the intention-to-treat approach and difficulties in defining adverse events .", "sentence_id": 9}
+{"abstract_id": "25438937", "label": "objective", "text": "Vitamin D insufficiency has been associated with impaired pancreatic beta-cell function .", "sentence_id": 0}
+{"abstract_id": "25438937", "label": "objective", "text": "We aimed to determine if high dose oral vitamin D@ ( D ) improves beta-cell function and glycaemia in type @ diabetes .", "sentence_id": 1}
+{"abstract_id": "25438937", "label": "methods", "text": "Fifty adults with type @ diabetes diagnosed less than @ months , with normal baseline serum @-OH D ( @D ) , were randomised to @ IU D ( n = @ ) or placebo ( n = @ ) daily for @ months .", "sentence_id": 2}
+{"abstract_id": "25438937", "label": "methods", "text": "Beta-cell function was measured by glucagon-stimulated serum C-peptide ( delta C-peptide -LSB- DCP -RSB- , nmol/l ) .", "sentence_id": 3}
+{"abstract_id": "25438937", "label": "methods", "text": "Secondary outcome measures were fasting plasma glucose ( FPG ) , post-prandial blood glucose ( PPG ) , HbA@c and insulin resistance ( HOMA-IR ) .", "sentence_id": 4}
+{"abstract_id": "25438937", "label": "results", "text": "In the D group , median serum @D ( nmol/l ) increased from @ to @ ( @ months ) and @ ( @ months ) and median serum @,@ D ( pmol/l ) from @ to @ and @ .", "sentence_id": 5}
+{"abstract_id": "25438937", "label": "results", "text": "After @ months , change in DCP from baseline in D ( +@ ) and placebo ( -@ ) was not different ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25438937", "label": "results", "text": "However , change in FPG ( mmol/l ) was significantly lower in D ( -@ ) compared to placebo ( +@ ) ( P = @ ) , as was the change in PPG in D ( -@ ) compared to placebo ( +@ ) ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25438937", "label": "results", "text": "Change in HbA@c ( % ) between D ( -@ ) and placebo ( -@ ) was not different ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25438937", "label": "results", "text": "At @ months , changes from baseline in DCP , FPG , PPG and HbA@c were not different between groups .", "sentence_id": 9}
+{"abstract_id": "25438937", "label": "conclusions", "text": "Oral D@ supplementation in type @ diabetes was associated with transient improvement in glycaemia , but without a measurable change in beta-cell function this effect is unlikely to be biologically significant .", "sentence_id": 10}
+{"abstract_id": "25438937", "label": "conclusions", "text": "High dose D@ therefore appears to offer little or no therapeutic benefit in type @ diabetes .", "sentence_id": 11}
+{"abstract_id": "24630881", "label": "objective", "text": "This study sought to evaluate the short - and long-term outcomes for smokers with non-ST-segment elevation acute coronary syndromes ( NSTE-ACS ) .", "sentence_id": 0}
+{"abstract_id": "24630881", "label": "background", "text": "Smoking has been associated with the `` paradox '' of reduced mortality after acute myocardial infarction ( MI ) .", "sentence_id": 1}
+{"abstract_id": "24630881", "label": "background", "text": "This is thought to be due to favorable baseline characteristics and less diffuse coronary artery disease ( CAD ) among smokers .", "sentence_id": 2}
+{"abstract_id": "24630881", "label": "methods", "text": "In the ACUITY ( Acute Catheterization and Urgent Intervention Triage Strategy ) trial , @,@ patients ( @ % smokers ) with moderate - to high-risk NSTE-ACS underwent angiography and , if indicated , revascularization .", "sentence_id": 3}
+{"abstract_id": "24630881", "label": "results", "text": "Smokers were significantly younger and had fewer comorbidities than nonsmokers .", "sentence_id": 4}
+{"abstract_id": "24630881", "label": "results", "text": "Incidence of death and MI were comparable at @ days , although smokers had significantly reduced risks of @-day major bleeding ( hazard ratio -LSB- HR -RSB- : @ , @ % confidence interval -LSB- CI -RSB- : @ to @ ; p = @ ) and @-year mortality ( HR : @ , @ % CI : @ to @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24630881", "label": "results", "text": "After correction for baseline and clinical differences , smoking was no longer predictive of major bleeding ( odds ratio : @ , @ % CI : @ to @ ; p = @ ) and was associated with higher @-year mortality ( HR : @ , @ % CI : @ to @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24630881", "label": "results", "text": "This pattern of reversed risk after multivariable correction held true for those smokers requiring percutaneous coronary intervention .", "sentence_id": 7}
+{"abstract_id": "24630881", "label": "results", "text": "Core laboratory angiographic analysis showed that smokers and nonsmokers were comparable in terms of the extent of CAD , Thrombolysis In Myocardial Infarction flow , myocardial blush , and the presence of thrombi .", "sentence_id": 8}
+{"abstract_id": "24630881", "label": "conclusions", "text": "In contrast to the paradox previously described in ST-segment elevation MI , our analysis finds smoking to be an independent predictor of higher @-year mortality in patients presenting with NSTE-ACS , and our angiographic study demonstrates CAD in smokers that is comparable to that in nonsmokers but evident @ decade earlier .", "sentence_id": 9}
+{"abstract_id": "24630881", "label": "conclusions", "text": "( Acute Catheterization and Urgent Intervention Triage Strategy -LSB- ACUITY -RSB- ; NCT@ ) .", "sentence_id": 10}
+{"abstract_id": "25216464", "label": "background", "text": "Despite empirical evidence demonstrating the effectiveness of collaborative stepped care program ( SCP ) in Western countries , such programs have not been evaluated in the east , which has a different services system structure and cultural nuances in seeking help for mental illness .", "sentence_id": 0}
+{"abstract_id": "25216464", "label": "background", "text": "Furthermore , only a few studies have used SCP for depression and anxiety prevention .", "sentence_id": 1}
+{"abstract_id": "25216464", "label": "background", "text": "We conducted a trial to test its effectiveness in preventing major depressive disorder and generalized anxiety disorder among primary care patients with subthreshold depression and/or anxiety in Hong Kong .", "sentence_id": 2}
+{"abstract_id": "25216464", "label": "methods", "text": "Subthreshold depression and/or anxiety patients were randomized into the SCP group ( n = @ ) or care as usual ( CAU ) group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25216464", "label": "methods", "text": "The SCP included watchful waiting , telephone counseling , problem solving therapy , and family doctor treatment within one year .", "sentence_id": 4}
+{"abstract_id": "25216464", "label": "methods", "text": "The primary outcome was the onset of major depressive disorder or generalized anxiety disorder in @ months .", "sentence_id": 5}
+{"abstract_id": "25216464", "label": "methods", "text": "The secondary outcomes were depressive and anxiety symptoms , quality of life and time absent from work due to any illness .", "sentence_id": 6}
+{"abstract_id": "25216464", "label": "results", "text": "Survival analysis showed no differences between the SCP and CAU groups ( the cumulative probability of onset at @ month was @ % in the SCP group and @ % in the CAU group ; Hazard Ratio = @ ; @ % Confidence Interval : @-@ @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25216464", "label": "results", "text": "No significant differences were found in secondary outcomes .", "sentence_id": 8}
+{"abstract_id": "25216464", "label": "conclusions", "text": "Sample size might not have been large enough .", "sentence_id": 9}
+{"abstract_id": "25216464", "label": "conclusions", "text": "SCP did not show beneficial effect on depression/anxiety prevention compared with CAU in Hong Kong primary care .", "sentence_id": 10}
+{"abstract_id": "25216464", "label": "conclusions", "text": "As a large majority of patients improved overtime without any intervention , we are not able to exclude the possibility that the intervention might be effective .", "sentence_id": 11}
+{"abstract_id": "25216464", "label": "conclusions", "text": "Future studies would need to have a larger sample size and conduct on patients with more severe symptoms or perform a second screening .", "sentence_id": 12}
+{"abstract_id": "24341963", "label": "objective", "text": "Compare the impact of two interventions , a web-based support and a folder support , for young persons who care for people who suffer from mental illness .", "sentence_id": 0}
+{"abstract_id": "24341963", "label": "methods", "text": "This study was a randomized control trial , following the CONSORT statements , which compared the impact of two interventions .", "sentence_id": 1}
+{"abstract_id": "24341963", "label": "methods", "text": "Primary outcome variable was stress , and secondary outcome variables were caring situation , general self-efficacy , well-being , health , and quality of life of young informal carers ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "24341963", "label": "methods", "text": "Data were collected in June @ to April @ , with self-assessment questionnaires , comparing the two interventions and also to detect changes .", "sentence_id": 3}
+{"abstract_id": "24341963", "label": "results", "text": "The stress levels were high in both groups at baseline , but decreased in the folder group .", "sentence_id": 4}
+{"abstract_id": "24341963", "label": "results", "text": "The folder group had improvement in their caring situation ( also different from the web group ) , general self-efficacy , well-being , and quality of life .", "sentence_id": 5}
+{"abstract_id": "24341963", "label": "results", "text": "The web group showed increase in well-being .", "sentence_id": 6}
+{"abstract_id": "24341963", "label": "conclusions", "text": "Young informal carers who take on the responsibility for people close to them ; suffer consequences on their own health .", "sentence_id": 7}
+{"abstract_id": "24341963", "label": "conclusions", "text": "They live in a life-situation characterized by high stress and low well-being .", "sentence_id": 8}
+{"abstract_id": "24341963", "label": "conclusions", "text": "This signals a need for support .", "sentence_id": 9}
+{"abstract_id": "24341963", "label": "conclusions", "text": "The non-significant differences show that each intervention can be effective , and that it depends upon the individual 's preferences .", "sentence_id": 10}
+{"abstract_id": "24341963", "label": "conclusions", "text": "This highlights the importance of adopting person-centered approach , in which young persons can themselves choose support strategy .", "sentence_id": 11}
+{"abstract_id": "25127210", "label": "background", "text": "Hydroxyethyl starch ( HES ) is commonly used as plasma expander during surgery but may be nephrotoxic as seen in studies in patients with sepsis .", "sentence_id": 0}
+{"abstract_id": "25127210", "label": "background", "text": "The authors hypothesized that the possible nephrotoxicity of @ % HES @/@ @ could be revealed by measurements of urinary excretion of neutrophil gelatinase-associated lipocalin ( u-NGAL ) in patients with normal renal function during hip arthroplasty .", "sentence_id": 1}
+{"abstract_id": "25127210", "label": "methods", "text": "In this randomized , double-blinded , placebo-controlled study , @ patients referred for hip arthroplasty received either @ % HES @/@ @ or isotonic saline @ % ; @ ml/kg during the first hour of surgery and @ ml/kg during the following hours ; @ patients completed the study .", "sentence_id": 2}
+{"abstract_id": "25127210", "label": "methods", "text": "U-NGAL , urine albumin , blood pressure , and plasma concentrations of creatinine , renin , NGAL , albumin , angiotensin-II , and aldosterone were measured before , during , and after surgery .", "sentence_id": 3}
+{"abstract_id": "25127210", "label": "methods", "text": "U-NGAL was defined as primary outcome .", "sentence_id": 4}
+{"abstract_id": "25127210", "label": "results", "text": "There were no significant differences in U-NGAL ( mean difference and @ % CI ) , plasma creatinine , and urine albumin during the study .", "sentence_id": 5}
+{"abstract_id": "25127210", "label": "results", "text": "U-NGAL and urine albumin increased significantly in both groups the morning after surgery but was normalized at follow-up after @ to @ days .", "sentence_id": 6}
+{"abstract_id": "25127210", "label": "results", "text": "Mean arterial pressure was significantly higher during the recovery period in the HES group compared with that in the control group ( @ -LSB- @ -RSB- and @ -LSB- @ -RSB- mmHg , mean -LSB- SD -RSB- , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25127210", "label": "results", "text": "Plasma renin and angiotensin-II were nonsignificantly different in both groups , whereas plasma aldosterone was significantly lower in the HES group .", "sentence_id": 8}
+{"abstract_id": "25127210", "label": "results", "text": "Plasma albumin was reduced in both groups , but to a significantly lower level in the HES group .", "sentence_id": 9}
+{"abstract_id": "25127210", "label": "conclusions", "text": "The study showed no evidence of a harmful effect of intraoperative infusion of @ % HES @/@ @ on renal function in patients during hip arthroplasty .", "sentence_id": 10}
+{"abstract_id": "25633037", "label": "background", "text": "We performed a multicentre randomised controlled trial to evaluate the effect on participation in organised screening programmes of a self-sampling device mailed home or picked up at a pharmacy compared with the standard recall letter .", "sentence_id": 0}
+{"abstract_id": "25633037", "label": "methods", "text": "Women aged @-@ non-responding to screening invitation were eligible .", "sentence_id": 1}
+{"abstract_id": "25633037", "label": "methods", "text": "Response rate to first invitation ranged from @ % to @ % between centres .", "sentence_id": 2}
+{"abstract_id": "25633037", "label": "methods", "text": "The control was the standard reminder letter to undergo the test used by the programme ( Pap test in three centres and HPV DNA test in three other centres ) .", "sentence_id": 3}
+{"abstract_id": "25633037", "label": "methods", "text": "Home mailing of the self-sampler was preceded by a letter with a leaflet about HPV .", "sentence_id": 4}
+{"abstract_id": "25633037", "label": "methods", "text": "The analysis was intention-to-treat .", "sentence_id": 5}
+{"abstract_id": "25633037", "label": "results", "text": "In all , @ women were randomised and recruited : @ in the control arm , @ to receive the self-sampler at home , and @ to pick up the self-sampler at a pharmacy .", "sentence_id": 6}
+{"abstract_id": "25633037", "label": "results", "text": "Participation was @ % in the control , @ % ( relative participation : @ ; @ % CI @-@ @ ) in home , and @ % ( relative participation : @ ; @ % CI @-@ @ ) in the pharmacy arms , respectively .", "sentence_id": 7}
+{"abstract_id": "25633037", "label": "results", "text": "The heterogeneity between centres was high ( excess heterogeneity of that expected due to chance , i.e. , I ( @ ) , @ % and @ % for home and pharmacy arm , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25633037", "label": "results", "text": "The estimated impact on the overall coverage was +@ % for home mail self-sampling compared with +@ % for standard reminder .", "sentence_id": 9}
+{"abstract_id": "25633037", "label": "conclusions", "text": "Home mailing of self-sampler proved to be an effective way to increase participation in screening programmes , even in those with HPV as primary testing .", "sentence_id": 10}
+{"abstract_id": "25633037", "label": "conclusions", "text": "Picking up at pharmacies showed effects varying from centre to centre .", "sentence_id": 11}
+{"abstract_id": "24738933", "label": "objective", "text": "Excessive menstrual bleeding , the most common complication caused by intrauterine devices ( IUDs ) , often leads to discontinuation of use .", "sentence_id": 0}
+{"abstract_id": "24738933", "label": "objective", "text": "Our study investigates the effect of vitamin B@ on menstrual bleeding and spotting after insertion of the TCu@A IUD .", "sentence_id": 1}
+{"abstract_id": "24738933", "label": "methods", "text": "This double-blind , randomised controlled trial involved @ Iranian women .", "sentence_id": 2}
+{"abstract_id": "24738933", "label": "methods", "text": "We recruited women who noted that their menstrual flow ( duration , amount , and number of sanitary pads needed ) or intermenstrual spotting had increased one month after the insertion of a TCu@A , and randomly assigned them to two groups .", "sentence_id": 3}
+{"abstract_id": "24738933", "label": "methods", "text": "The intervention group and the control group received @ mg of vitamin B@ or a placebo , respectively , daily , for three months .", "sentence_id": 4}
+{"abstract_id": "24738933", "label": "methods", "text": "We followed all participants for four months .", "sentence_id": 5}
+{"abstract_id": "24738933", "label": "methods", "text": "The Higham scale was used for estimating the volume of menstrual bleeding .", "sentence_id": 6}
+{"abstract_id": "24738933", "label": "methods", "text": "The Mann-Whitney test , paired t-test , independent t-test and Repeated Measure test were used for statistical purposes .", "sentence_id": 7}
+{"abstract_id": "24738933", "label": "results", "text": "In the intervention group the duration of menstrual bleeding , the number of sanitary pads and the amount of spotting decreased significantly compared to the control group ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24738933", "label": "conclusions", "text": "Vitamin B@ is a safe , natural and cost-effective supplement that is devoid of side effects and reduces menstrual bleeding and spotting caused by a copper bearing-IUD .", "sentence_id": 9}
+{"abstract_id": "25739829", "label": "objective", "text": "The RITUXVAS trial reported similar remission induction rates and safety between rituximab and cyclophosphamide based regimens for antineutrophil cytoplasm antibody ( ANCA ) - associated vasculitis at @months ; however , immunosuppression maintenance requirements and longer-term outcomes after rituximab in ANCA-associated renal vasculitis are unknown .", "sentence_id": 0}
+{"abstract_id": "25739829", "label": "methods", "text": "Forty-four patients with newly diagnosed ANCA-associated vasculitis and renal involvement were randomised , @:@ , to glucocorticoids plus either rituximab ( @mg/m ( @ ) / week@ ) with two intravenous cyclophosphamide pulses ( n = @ , rituximab group ) , or intravenous cyclophosphamide for @-@months followed by azathioprine ( n = @ , control group ) .", "sentence_id": 1}
+{"abstract_id": "25739829", "label": "results", "text": "The primary end point at @months was a composite of death , end-stage renal disease and relapse , which occurred in @/@ in the rituximab group ( @ % ) and @/@ in the control group ( @ % ) ( p = @ ) .", "sentence_id": 2}
+{"abstract_id": "25739829", "label": "results", "text": "After remission induction treatment all patients in the rituximab group achieved complete B cell depletion and during subsequent follow-up , @/@ ( @ % ) had B cell return .", "sentence_id": 3}
+{"abstract_id": "25739829", "label": "results", "text": "Relapses occurred in seven in the rituximab group ( @ % ) and two in the control group ( @ % ) ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "25739829", "label": "results", "text": "All relapses in the rituximab group occurred after B cell return .", "sentence_id": 5}
+{"abstract_id": "25739829", "label": "conclusions", "text": "At @months , rates of the composite outcome of death , end-stage renal disease and relapse did not differ between groups .", "sentence_id": 6}
+{"abstract_id": "25739829", "label": "conclusions", "text": "In the rituximab group , B cell return was associated with relapse .", "sentence_id": 7}
+{"abstract_id": "24665578", "label": "objective", "text": "Physical activity is a common stimulus of asthmatic symptoms manifestation .", "sentence_id": 0}
+{"abstract_id": "24665578", "label": "objective", "text": "Airway hyperreactivity is a predisposing cause of exercise induced bronchial obstruction , diagnosed by histamine inhalation .", "sentence_id": 1}
+{"abstract_id": "24665578", "label": "objective", "text": "The aim of this study was to determine the relation between the amounts of histamine needed to induce non-specific airway hyperreactivity and exercise-induced bronchial obstruction .", "sentence_id": 2}
+{"abstract_id": "24665578", "label": "methods", "text": "This randomized cross-over study included @ male patients ( age @-@ years ) suffering from bronchial asthma who showed positive results as the reaction after the histamine bronchial provocation test .", "sentence_id": 3}
+{"abstract_id": "24665578", "label": "methods", "text": "Histamine concentrations were in a range of @ to @ mg/mL .", "sentence_id": 4}
+{"abstract_id": "24665578", "label": "methods", "text": "Each patient participated in the exercise stress test conducted on a conveyor belt .", "sentence_id": 5}
+{"abstract_id": "24665578", "label": "methods", "text": "The results of the exercise stress test were considered positive if the FEV@ level dropped by at least @ % from its initial value , @-@ minutes after the test .", "sentence_id": 6}
+{"abstract_id": "24665578", "label": "results", "text": "All the patients showed positive results as the reaction after the histamine bronchial provocation test , while @ of them showed positive results after the exercise-induced stress test .", "sentence_id": 7}
+{"abstract_id": "24665578", "label": "results", "text": "There was a statistically highly significant difference in administrated histamine concentrations between the group of patients that had positive results on exercise stress test and those who did not ( @ mg/mL vs @ mg/mL ; U = @ ; p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24665578", "label": "results", "text": "Also , there was a statistically significant difference concerning the frequency of the positive results regarding histamine concentration after induced stress test ( chi@ = @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24665578", "label": "results", "text": "Among the patients with positive results , there was a statistically highly significant number of patients with bronchial obstruction induced by less than @ mg/mL of histamine ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24665578", "label": "results", "text": "A statistically significant relation between the amount of histamine needed to induce bronchial obstruction and the results of the exercise stress test ( p < @ ) was also observed after the testing .", "sentence_id": 11}
+{"abstract_id": "24665578", "label": "conclusions", "text": "In the group of patients with positive results after the exercise-induced stress test , there were significantly more patients with positive results to non-specific bronchial provocation test with lower histamine concentrations .", "sentence_id": 12}
+{"abstract_id": "24665578", "label": "conclusions", "text": "Histamine concentrations needed to induce non-specific hyperreactivity of asthmatic airway were shown to be related to the reactivity to physical effort .", "sentence_id": 13}
+{"abstract_id": "25937378", "label": "objective", "text": "The question of whether the placement of the dominant hand against the sternum could improve the quality of manual chest compressions remains controversial .", "sentence_id": 0}
+{"abstract_id": "25937378", "label": "objective", "text": "In the present study , we evaluated the influence of dominant vs nondominant hand positioning on the quality of conventional cardiopulmonary resuscitation ( CPR ) during prolonged basic life support ( BLS ) by rescuers who performed optimal and suboptimal compressions .", "sentence_id": 1}
+{"abstract_id": "25937378", "label": "methods", "text": "Six months after completing a standard BLS training course , @ medical students were instructed to perform adult single-rescuer BLS for @ minutes on a manikin with a randomized hand position .", "sentence_id": 2}
+{"abstract_id": "25937378", "label": "methods", "text": "Twenty-four hours later , the students placed the opposite hand in contact with the sternum while performing CPR .", "sentence_id": 3}
+{"abstract_id": "25937378", "label": "methods", "text": "Those with an average compression depth of less than @ mm were considered suboptimal .", "sentence_id": 4}
+{"abstract_id": "25937378", "label": "results", "text": "Participants who had performed suboptimal compressions were significantly shorter ( @ @ vs @ @ cm , P = @ ) and lighter ( @ @ vs @ @ kg , P < @ ) than those who performed optimal compressions .", "sentence_id": 5}
+{"abstract_id": "25937378", "label": "results", "text": "No significant differences in CPR quality were observed between dominant and nondominant hand placements for these who had an average compression depth of greater than @ mm .", "sentence_id": 6}
+{"abstract_id": "25937378", "label": "results", "text": "However , both the compression depth ( @ @ vs @ @ mm , P = @ ) and proportion of chest compressions with an appropriate depth ( @ % @ % vs @ % @ % , P = @ ) were remarkably higher when compressing the chest with the dominant hand against the sternum for those who performed suboptimal CPR .", "sentence_id": 7}
+{"abstract_id": "25937378", "label": "conclusions", "text": "Chest compression quality significantly improved when the dominant hand was placed against the sternum for those who performed suboptimal compressions during conventional CPR .", "sentence_id": 8}
+{"abstract_id": "25745751", "label": "objective", "text": "To investigate whether cabergoline ( Cb@ ) , a dopamine agonist , reduces ovarian hyperstimulation syndrome ( OHSS ) in high-risk women undergoing assisted reproductive technology ( ART ) , and to analyze whether cabergoline affects the outcome of ART .", "sentence_id": 0}
+{"abstract_id": "25745751", "label": "methods", "text": "Forty infertile women at risk of developing OHSS were enrolled in the trial .", "sentence_id": 1}
+{"abstract_id": "25745751", "label": "methods", "text": "The inclusion criteria were as follows : infertile women undergoing IVF with serum estradiol concentration > @,@ pg/mL or with > @ follicles > @ mm on the day of human chorionic gonadotropin ( hCG ) administration , and @-@ years of age .", "sentence_id": 2}
+{"abstract_id": "25745751", "label": "methods", "text": "They were randomized into @ groups : the Cb@ group ( n = @ ) received @ mg oral Cb@ per day for @ consecutive days beginning on the day of hCG , and the control group ( n = @ ) received no medication .", "sentence_id": 3}
+{"abstract_id": "25745751", "label": "results", "text": "Ascites was significantly lower ( p = @ ) in the Cb@ group as compared with the control group .", "sentence_id": 4}
+{"abstract_id": "25745751", "label": "results", "text": "The incidence of moderate OHSS was also significantly lower ( p = @ ) in the Cb@ as compared to the control group .", "sentence_id": 5}
+{"abstract_id": "25745751", "label": "results", "text": "There was no evidence of statistically significant differences regarding the parameters of ART outcome .", "sentence_id": 6}
+{"abstract_id": "25745751", "label": "conclusions", "text": "Our data supports the use of Cb@ in the management of high-risk women undergoing ART and , consequently , achieving lowered risk of OHSS , with no deleterious impact on ART outcomes .", "sentence_id": 7}
+{"abstract_id": "24625519", "label": "objective", "text": "The use of peripherally inserted central venous catheters ( PICC lines ) has reduced the mortality and morbidity of premature newborns .", "sentence_id": 0}
+{"abstract_id": "24625519", "label": "objective", "text": "The usual sites of insertion are the veins in the upper arms but other locations are being used as well .", "sentence_id": 1}
+{"abstract_id": "24625519", "label": "methods", "text": "To examine whether using the axillary vein as a site of insertion of a PICC line affects the frequency of complications .", "sentence_id": 2}
+{"abstract_id": "24625519", "label": "methods", "text": "Our study has a clinical trial design .", "sentence_id": 3}
+{"abstract_id": "24625519", "label": "methods", "text": "A total of @ neonates that had a PICC line inserted were recruited and randomly divided equally in two groups : in Group A ( mean birth weight , standard deviation ( s.d. ) = @ ( @ ) g ) , the PICC line was inserted through the axillary vein , and in Group B ( birth weight = @ ( @ ) g ) , the PICC line was inserted in other sites further from the axillary vein .", "sentence_id": 4}
+{"abstract_id": "24625519", "label": "methods", "text": "The outcomes measured were the total PICC line-related complications , the reason for removing the catheter , the number of total attempts until successful insertion and the mean duration of stay of the catheter .", "sentence_id": 5}
+{"abstract_id": "24625519", "label": "methods", "text": "The likelihood of having an adverse outcome was assessed with Mantel-Haenszel odds ratio ( OR ) .", "sentence_id": 6}
+{"abstract_id": "24625519", "label": "results", "text": "Premature neonates with axillary PICC lines were @ times less likely to have line-related complications ( inflammation , blockage , edema , infection ) as compared with any other site of insertion ( OR = @ % , confidence interval ( CI ) = @ ( @ to @ ) ) and they were seven times more likely to have the PICC line removed because they achieved full enteral nutrition as compared with the other causes ( OR @ % , confidence interval ( CI ) = @ ( @ to @ ) ) .", "sentence_id": 7}
+{"abstract_id": "24625519", "label": "results", "text": "There was no statistical difference between the two groups in the number of attempts until successful PICC line insertion ( P = @ ) and the mean duration of stay of the PICC line ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24625519", "label": "conclusions", "text": "The use of the axillary vein as a site of insertion of a PICC line was correlated with significantly less complications in premature newborns as opposed to the other sites of insertion .", "sentence_id": 9}
+{"abstract_id": "24301456", "label": "background", "text": "Human equilibrative nucleoside transporter @ ( hENT@ ) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection .", "sentence_id": 0}
+{"abstract_id": "24301456", "label": "methods", "text": "Microarrays from @ patients randomized to chemotherapy in the ESPAC-@ trial ( plus controls from ESPAC-@ / @ ) were stained with the @D@G@ anti-hENT@ antibody .", "sentence_id": 1}
+{"abstract_id": "24301456", "label": "methods", "text": "Patients were classified as having high hENT@ expression if the mean H score for their cores was above the overall median H score ( @ ) .", "sentence_id": 2}
+{"abstract_id": "24301456", "label": "methods", "text": "High and low hENT@-expressing groups were compared using Kaplan-Meier curves , log-rank tests , and Cox proportional hazards models .", "sentence_id": 3}
+{"abstract_id": "24301456", "label": "methods", "text": "All statistical tests were two-sided .", "sentence_id": 4}
+{"abstract_id": "24301456", "label": "results", "text": "Three hundred eighty patients ( @ % ) and @ cores were suitable and included in the final analysis .", "sentence_id": 5}
+{"abstract_id": "24301456", "label": "results", "text": "Median overall survival for gemcitabine-treated patients ( n = @ ) was @ ( @ % confidence interval -LSB- CI -RSB- = @ to @ ) months vs @ ( @ % CI = @ to @ ) months for @ patients treated with @-fluorouracil/folinic acid ( ( @ ) @ = @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24301456", "label": "results", "text": "Median survival for patients treated with gemcitabine was @ ( @ % CI = @ to @ ) months for those with low hENT@ expression vs @ ( @ % CI = @ to @ ) months for those with high hENT@ expression ( ( @ ) = @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24301456", "label": "results", "text": "For the @-fluorouracil group , median survival was @ ( @ % CI = @ to @ ) and @ ( @ % CI = @ to @ ) months for those with low and high hENT@ expression , respectively ( ( @ ) = @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24301456", "label": "results", "text": "hENT@ levels were not predictive of survival for the @ patients of the observation group ( ( @ ) = @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24301456", "label": "results", "text": "Multivariable analysis confirmed hENT@ expression as a predictive marker in gemcitabine-treated ( Wald ( @ ) = @ ; P = @ ) but not @-fluorouracil-treated ( Wald ( @ ) = @ ; P = @ ) patients .", "sentence_id": 10}
+{"abstract_id": "24301456", "label": "conclusions", "text": "Subject to prospective validation , gemcitabine should not be used for patients with low tumor hENT@ expression .", "sentence_id": 11}
+{"abstract_id": "24517053", "label": "objective", "text": "To evaluate the clinical efficacy of a series of Tongfeng Granule ( TG ) in treating gouty arthritis patients in different stages .", "sentence_id": 0}
+{"abstract_id": "24517053", "label": "methods", "text": "Ninety primary gout patients were randomly assigned to two groups , the TCM treatment group ( @ cases ) and the Western medicine control group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "24517053", "label": "methods", "text": "Huzhang Tongfeng Granule in combination of external application of Jinhuang Ointment were given to those in the TCM treatment group in the acute phase , and Yinlian Tongfeng Granule in the remission phase .", "sentence_id": 2}
+{"abstract_id": "24517053", "label": "methods", "text": "Diclofenac Sodium Sustained Release Capsule in combination of external application of Jinhuang Ointment were given to those in the Western medicine control group in the acute phase , and Benzbromarone in the remission phase .", "sentence_id": 3}
+{"abstract_id": "24517053", "label": "methods", "text": "All were treated for three months .", "sentence_id": 4}
+{"abstract_id": "24517053", "label": "methods", "text": "The severity integral of symptoms , effective time , effective rate in the acute phase , the recurrence rate , blood uric acid ( BUA ) , urine uric acid ( UUA ) , serum creatinine ( SCr ) , blood urea nitrogen ( BUN ) , triglyceride ( TG ) , total cholesterol ( TC ) , fasting plasma glucose ( FPG ) , and the incidence of adverse reactions were observed in the two groups during the course of treatment .", "sentence_id": 5}
+{"abstract_id": "24517053", "label": "results", "text": "The severity integral of symptoms was lowered in the two groups when compared with a former time point ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24517053", "label": "results", "text": "There was no statistical difference in markedly effective rate or the effective rate in the acute phase between the two groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24517053", "label": "results", "text": "There was statistical difference in the difference of BUA or UUA between before and after treatment in the two groups ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24517053", "label": "results", "text": "There was statistical difference in TG and SCr in the TCM group between after treatment and before treatment ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24517053", "label": "results", "text": "There was statistical difference in TG and SCr in the two groups between after treatment and before treatment ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24517053", "label": "results", "text": "The recurrence rate was @ % in the TCM treatment group ( @/@ ) , lower than that of the Western medicine control group ( @ % , @/@ , P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24517053", "label": "conclusions", "text": "A series of Tongfeng Granule could promote the excretion of UUA , reduce the BUA level in the intermission phase , and play a favorable role in the prevention of relapse .", "sentence_id": 12}
+{"abstract_id": "24517053", "label": "conclusions", "text": "Huzhang Tongfeng Granule could significantly improve inflammatory symptoms and signs of gouty arthritis patients in the acute phase .", "sentence_id": 13}
+{"abstract_id": "24670844", "label": "objective", "text": "National Surgical Adjuvant Breast and Bowel Project ( NSABP ) R-@ was a randomized controlled trial of neoadjuvant chemoradiotherapy in patients with resectable stage II-III rectal cancer .", "sentence_id": 0}
+{"abstract_id": "24670844", "label": "objective", "text": "We hypothesized that patients who underwent abdominoperineal resection ( APR ) would have a poorer quality of life than those who underwent sphincter-sparing surgery ( SSS ) .", "sentence_id": 1}
+{"abstract_id": "24670844", "label": "methods", "text": "To obtain patient-reported outcomes ( PROs ) we administered two symptom scales at baseline and @ year postoperatively : the Functional Assessment of Cancer Therapy-Colorectal ( FACT-C ) and the European Organization for the Research and Treatment of Cancer module for patients with Colorectal Cancer Quality of Life Questionnaire ( EORTC QLQ-CR@ ) .", "sentence_id": 2}
+{"abstract_id": "24670844", "label": "methods", "text": "Scoring was stratified by nonrandomly assigned definitive surgery ( APR vs SSS ) .", "sentence_id": 3}
+{"abstract_id": "24670844", "label": "methods", "text": "Analyses controlled for baseline scores and stratification factors : age , sex , stage , intended surgery , and randomly assigned chemoradiotherapy .", "sentence_id": 4}
+{"abstract_id": "24670844", "label": "results", "text": "Of @,@ randomly assigned patients , @ had data for planned analyses ; @ % underwent SSS ; @ % underwent APR. .", "sentence_id": 5}
+{"abstract_id": "24670844", "label": "results", "text": "FACT-C total and subscale scores were not statistically different by surgery at @ year .", "sentence_id": 6}
+{"abstract_id": "24670844", "label": "results", "text": "For the EORTC QLQ-CR@ functional scales , APR patients reported worse body image ( @ vs @ , P = @ ) at @ year than did SSS patients .", "sentence_id": 7}
+{"abstract_id": "24670844", "label": "results", "text": "Males undergoing APR reported worse sexual enjoyment ( @ vs @ , P = @ ) at @ year than did those undergoing SSS .", "sentence_id": 8}
+{"abstract_id": "24670844", "label": "results", "text": "For the EORTC QLQ-CR@ symptom scale scores , APR patients reported worse micturition symptoms than the SSS group at @ year ( @ vs @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24670844", "label": "results", "text": "SSS patients reported worse gastrointestinal tract symptoms than did the APR patients ( @ vs @ , P < @ ) , as well as weight loss ( @ vs @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24670844", "label": "conclusions", "text": "Symptoms and functional problems were detected at @ year by EORTC QLQ-CR@ , reflecting different symptom profiles in patients who underwent APR than those who underwent SSS .", "sentence_id": 11}
+{"abstract_id": "24670844", "label": "conclusions", "text": "Information from these PROs may be useful in counseling patients anticipating surgery for rectal cancer .", "sentence_id": 12}
+{"abstract_id": "24326593", "label": "background", "text": "Proximal humeral fractures are mainly associated with osteoporosis and are becoming more common with the aging of our society .", "sentence_id": 0}
+{"abstract_id": "24326593", "label": "background", "text": "The best surgical approach for internal fixation of displaced proximal humeral fractures is still being debated .", "sentence_id": 1}
+{"abstract_id": "24326593", "label": "objective", "text": "In this prospective randomized study , we aimed to investigate whether the deltoid-split approach is superior to the deltopectoral approach with regard to ( @ ) complication rate ; ( @ ) shoulder function ( Constant score ) ; and ( @ ) pain ( visual analog scale -LSB- VAS -RSB- ) for internal fixation of displaced humeral fractures with a polyaxial locking plate .", "sentence_id": 2}
+{"abstract_id": "24326593", "label": "methods", "text": "We randomized @ patients with proximal humeral fractures to receive one of these two approaches ( @ patients for each approach ) .", "sentence_id": 3}
+{"abstract_id": "24326593", "label": "methods", "text": "We prospectively documented demographic and perioperative data ( sex , age , fracture type , hospital stay , operation time , and fluoroscopy time ) as well as complications .", "sentence_id": 4}
+{"abstract_id": "24326593", "label": "methods", "text": "Followup examinations were conducted at @ weeks , @ months , and @ months postoperatively , including radiological and clinical evaluations ( Constant score , activities of daily living , and pain -LSB- VAS -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "24326593", "label": "methods", "text": "Baseline and perioperative data were comparable for both approaches .", "sentence_id": 6}
+{"abstract_id": "24326593", "label": "methods", "text": "The sample size was chosen to provide @ % power , but it reached only @ % as a result of the loss of followups to detect a @-point difference on the Constant score , which we considered the minimum clinically important difference .", "sentence_id": 7}
+{"abstract_id": "24326593", "label": "results", "text": "Complications or reoperations between the approaches were not different .", "sentence_id": 8}
+{"abstract_id": "24326593", "label": "results", "text": "Eight patients in the deltoid-split group ( @ % ) needed surgical revisions compared with seven patients in the deltopectoral group ( @ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24326593", "label": "results", "text": "Deltoid-split and deltopectoral approaches showed similar Constant scores @ months postoperatively ( Deltoid-split @ ; @ % confidence interval -LSB- CI -RSB- , @-@ versus deltopectoral @ ; @ % CI , @-@ ; p = @ ) , and there were no differences between the groups in terms of pain at @ year ( deltoid-split @ ; @ % CI , @-@ @ versus deltopectoral @ ; @ % CI , @-@ @ ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24326593", "label": "results", "text": "No learning-curve effects were noted ; fluoroscopy use during surgery and function and pain scores during followups were similar among the first @ patients and the next @ patients treated in each group .", "sentence_id": 11}
+{"abstract_id": "24326593", "label": "conclusions", "text": "The treatment of proximal humeral fractures with a polyaxial locking plate is reliable using both approaches .", "sentence_id": 12}
+{"abstract_id": "24326593", "label": "conclusions", "text": "For a definitive recommendation for one of these approaches , further studies with appropriate sample size are necessary .", "sentence_id": 13}
+{"abstract_id": "24326593", "label": "methods", "text": "Level II , therapeutic study .", "sentence_id": 14}
+{"abstract_id": "24326593", "label": "methods", "text": "See the Guidelines for Authors for a complete description of levels of evidence .", "sentence_id": 15}
+{"abstract_id": "25147092", "label": "objective", "text": "To assess whether chewing gum prevents postoperative ileus after laparotomy for benign gynecologic surgery .", "sentence_id": 0}
+{"abstract_id": "25147092", "label": "methods", "text": "A randomized study was conducted from December @ , @ , to February @ , @ .", "sentence_id": 1}
+{"abstract_id": "25147092", "label": "methods", "text": "Patients scheduled to undergo laparotomy were randomly assigned to receive chewing gum or routine care after surgery .", "sentence_id": 2}
+{"abstract_id": "25147092", "label": "methods", "text": "A chart review was performed to establish incidence of nausea and vomiting , use of antiemetics , cases of postoperative ileus ( @ episodes of emesis of @ mL or more , with abdominal distention and absence of bowel sounds ) , and time to discharge .", "sentence_id": 3}
+{"abstract_id": "25147092", "label": "methods", "text": "Inpatient surveys recorded the time to specific events .", "sentence_id": 4}
+{"abstract_id": "25147092", "label": "results", "text": "A total of @ patients were randomly assigned to receive chewing gum ( n = @ ) or routine postoperative care ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25147092", "label": "results", "text": "Fewer participants assigned to receive chewing gum than routine care experienced postoperative nausea ( @ -LSB- @ % -RSB- versus @ -LSB- @ % -RSB- ; P = @ ) and postoperative ileus ( @ vs. @ -LSB- @ % -RSB- ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25147092", "label": "results", "text": "There were no differences in the need for postoperative antiemetics , episodes of postoperative vomiting , readmissions , repeat surgeries , time to first hunger , time to toleration of clear liquids , time to regular diet , time to first flatus , or time to discharge .", "sentence_id": 7}
+{"abstract_id": "25147092", "label": "conclusions", "text": "Chewing gum after laparotomy for gynecologic surgery is safe and lowers the incidence of postoperative ileus and nausea .", "sentence_id": 8}
+{"abstract_id": "25147092", "label": "conclusions", "text": "ClinicalTrials.gov : NCT@ .", "sentence_id": 9}
+{"abstract_id": "25593051", "label": "background", "text": "Among patients without cardiovascular disease ( CVD ) and low @-year CVD risk , the risks of gastrointestinal bleeding and hemorrhagic strokes associated with aspirin use outweigh any potential atheroprotective benefit .", "sentence_id": 0}
+{"abstract_id": "25593051", "label": "background", "text": "According to the guidelines on primary prevention of CVD , aspirin use is considered appropriate only in patients with @-year CVD risk @ % and inappropriate in patients with @-year CVD risk < @ % .", "sentence_id": 1}
+{"abstract_id": "25593051", "label": "objective", "text": "The goal of this study was to examine the frequency and practice-level variation in inappropriate aspirin use for primary prevention in a large U.S. nationwide registry .", "sentence_id": 2}
+{"abstract_id": "25593051", "label": "methods", "text": "Within the National Cardiovascular Disease Registry 's Practice Innovation and Clinical Excellence registry , we assessed @,@ unique patients receiving aspirin for primary prevention from @ U.S. practices .", "sentence_id": 3}
+{"abstract_id": "25593051", "label": "methods", "text": "The frequency of inappropriate aspirin use was determined for primary prevention ( aspirin use in those with @-year CVD risk < @ % ) .", "sentence_id": 4}
+{"abstract_id": "25593051", "label": "methods", "text": "Using hierarchical regression models , the extent of practice-level variation using the median rate ratio ( MRR ) was assessed .", "sentence_id": 5}
+{"abstract_id": "25593051", "label": "results", "text": "Inappropriate aspirin use frequency was @ % ( @,@ of @,@ ) in the overall cohort .", "sentence_id": 6}
+{"abstract_id": "25593051", "label": "results", "text": "There was significant practice-level variation in inappropriate use ( range @ % to @ % ; median @ % ; interquartile range @ % ) for practices ; adjusted MRR was @ ( @ % confidence interval -LSB- CI -RSB- : @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25593051", "label": "results", "text": "Results remained consistent after excluding @,@ women age @ years ( inappropriate aspirin use @ % ; median practice-level inappropriate aspirin use @ % ; interquartile range @ % ; adjusted MRR @ -LSB- @ % CI : @ to @ -RSB- ) and after excluding patients with diabetes ( inappropriate aspirin use @ % ; median practice-level inappropriate aspirin use @ % ; interquartile range @ % ; adjusted MRR @ -LSB- @ % CI : @ to @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "25593051", "label": "conclusions", "text": "More than @ in @ patients in this national registry were receiving inappropriate aspirin therapy for primary prevention , with significant practice-level variations .", "sentence_id": 9}
+{"abstract_id": "25593051", "label": "conclusions", "text": "Our findings suggest that there are important opportunities to improve evidence-based aspirin use for the primary prevention of CVD .", "sentence_id": 10}
+{"abstract_id": "25342898", "label": "background", "text": "Combining bronchodilators with different mechanisms of action may improve efficacy and reduce risk of side effects compared to increasing the dose of a single agent in chronic obstructive pulmonary disease ( COPD ) .", "sentence_id": 0}
+{"abstract_id": "25342898", "label": "background", "text": "We investigated this by combining two long-acting bronchodilators : once-daily muscarinic antagonist tiotropium and once-daily @-agonist olodaterol .", "sentence_id": 1}
+{"abstract_id": "25342898", "label": "methods", "text": "Two replicate , double-blind , randomized , @-week studies ( ANHELTO @ -LSB- NCT@ -RSB- and ANHELTO @ -LSB- NCT@ -RSB- ) evaluated the efficacy and safety of olodaterol @ g once daily ( via Respimat ( ) ) combined with tiotropium @ g once daily ( via HandiHaler ( ) ) versus tiotropium @ g once daily ( via HandiHaler ( ) ) combined with placebo ( via Respimat ( ) ) in patients with moderate to severe COPD .", "sentence_id": 2}
+{"abstract_id": "25342898", "label": "methods", "text": "Primary efficacy end points were area under the curve from @-@ hours of forced expiratory volume in @ second ( FEV@ AUC@-@ ) and trough FEV@ after @ weeks ( for the individual trials ) .", "sentence_id": 3}
+{"abstract_id": "25342898", "label": "methods", "text": "A key secondary end point was health status by St George 's Respiratory Questionnaire ( SGRQ ) total score ( combined data set ) .", "sentence_id": 4}
+{"abstract_id": "25342898", "label": "results", "text": "Olodaterol + tiotropium resulted in significant improvements over tiotropium + placebo in FEV@ AUC@-@ ( treatment differences : @ L -LSB- P < @ -RSB- , ANHELTO @ ; @ L -LSB- P < @ -RSB- , ANHELTO @ ) and trough FEV@ ( treatment differences : @ L -LSB- P < @ -RSB- , ANHELTO @ ; @ L -LSB- P = @ -RSB- , ANHELTO @ ) ; these were supported by secondary end points .", "sentence_id": 5}
+{"abstract_id": "25342898", "label": "results", "text": "These effects translated to improvements in SGRQ total scores ( treatment difference -@ ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25342898", "label": "results", "text": "The tolerability profile of olodaterol + tiotropium was similar to tiotropium monotherapy .", "sentence_id": 7}
+{"abstract_id": "25342898", "label": "conclusions", "text": "These studies demonstrated that olodaterol ( Respimat ( ) ) and tiotropium ( HandiHaler ( ) ) provided bronchodilatory effects above tiotropium alone in patients with COPD .", "sentence_id": 8}
+{"abstract_id": "25342898", "label": "conclusions", "text": "In general , both treatments were well tolerated .", "sentence_id": 9}
+{"abstract_id": "25446409", "label": "objective", "text": "To compare surgical outcomes of volar locking plates ( VP ) and external fixation ( EF ) ( with or without intra-focal fixation ) for AO-type C@ and C@ fractures of the distal radius .", "sentence_id": 0}
+{"abstract_id": "25446409", "label": "methods", "text": "From an initial group of @ patients with AO-type C@ and C@ distal radius fractures who were enrolled in a prospective , randomized study comparing volar plate fixation with external fixation ( with or without intra-focal fixation ) , @ patients were studied .", "sentence_id": 1}
+{"abstract_id": "25446409", "label": "methods", "text": "The researchers evaluated functional assessments ( wrist range of motion , grip strength , and Michigan Hand Questionnaire ) at each patient visit and measured radiographic assessment ( radial inclination , volar tilt , ulnar variance , and articular congruity ) at @ months .", "sentence_id": 2}
+{"abstract_id": "25446409", "label": "results", "text": "The grip strength of the VP group was significantly greater than that of the EF group at @ and @ months .", "sentence_id": 3}
+{"abstract_id": "25446409", "label": "results", "text": "The range of motion was significantly greater in the VP group than in the EF group at @ months .", "sentence_id": 4}
+{"abstract_id": "25446409", "label": "results", "text": "There were no significant differences in the range of motion and grip strength between the @ groups at @ months .", "sentence_id": 5}
+{"abstract_id": "25446409", "label": "results", "text": "The Michigan Hand Questionnaire score was higher in the VP group than in the EF group at @ months but was same at @ months .", "sentence_id": 6}
+{"abstract_id": "25446409", "label": "results", "text": "There was no significant difference between groups with respect to volar tilt or radial inclination .", "sentence_id": 7}
+{"abstract_id": "25446409", "label": "results", "text": "The VP group showed superior radiologic outcomes in terms of the ulnar variance .", "sentence_id": 8}
+{"abstract_id": "25446409", "label": "results", "text": "One patient in the VP group and @ in the EF group had an intra-articular stepoff deformity greater than @ mm .", "sentence_id": 9}
+{"abstract_id": "25446409", "label": "results", "text": "This difference did not reach statistical significance .", "sentence_id": 10}
+{"abstract_id": "25446409", "label": "conclusions", "text": "These results for functional recovery after distal radius surgery offer insight into treatment decisions and interpretations of treatment outcomes for patients with comminuted intra-articular distal radius fractures .", "sentence_id": 11}
+{"abstract_id": "25185099", "label": "objective", "text": "Currently , antiangiogenic strategies in metastatic breast cancer have demonstrated modest improvements in progression-free survival ( PFS ) but not improved quality or duration of survival , warranting evaluation of new agents in a placebo-controlled setting .", "sentence_id": 0}
+{"abstract_id": "25185099", "label": "objective", "text": "Ramucirumab is a human immunoglobulin G@ antibody that binds vascular endothelial growth factor receptor-@ and blocks ligand-stimulated activation .", "sentence_id": 1}
+{"abstract_id": "25185099", "label": "objective", "text": "The ROSE/TRIO -@ trial evaluated ramucirumab with docetaxel in unresectable , locally recurrent , or metastatic breast cancer .", "sentence_id": 2}
+{"abstract_id": "25185099", "label": "methods", "text": "In this double-blind , placebo-controlled , randomized , multinational phase III trial , @,@ patients with human epidermal growth factor receptor @ ( HER@ ) - negative breast cancer who had not received cytotoxic chemotherapy in the advanced setting were randomly assigned at a two-to-one ratio to receive docetaxel @ mg/m ( @ ) plus ramucirumab @ mg/kg or docetaxel @ mg/m ( @ ) plus placebo once every @ weeks .", "sentence_id": 3}
+{"abstract_id": "25185099", "label": "methods", "text": "Treatment continued until disease progression , unacceptable toxicity , or other withdrawal criteria .", "sentence_id": 4}
+{"abstract_id": "25185099", "label": "methods", "text": "Patients were stratified by previous taxane therapy , visceral metastasis , hormone receptor status , and geographic region .", "sentence_id": 5}
+{"abstract_id": "25185099", "label": "methods", "text": "An independent data monitoring committee oversaw the trial .", "sentence_id": 6}
+{"abstract_id": "25185099", "label": "methods", "text": "The primary end point was investigator-assessed PFS .", "sentence_id": 7}
+{"abstract_id": "25185099", "label": "results", "text": "Median PFS in patients treated with ramucirumab plus docetaxel was @ months , compared with @ months in patients who received placebo plus docetaxel ( hazard ratio -LSB- HR -RSB- , @ ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25185099", "label": "results", "text": "Median overall survival was @ months in patients who received ramucirumab plus docetaxel , compared with @ months in patients who received placebo plus docetaxel ( HR , @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25185099", "label": "results", "text": "Toxicities seen at significantly higher rates in patients receiving ramucirumab included fatigue , hypertension , febrile neutropenia , palmar-plantar erythrodysesthesia syndrome , and stomatitis .", "sentence_id": 10}
+{"abstract_id": "25185099", "label": "conclusions", "text": "Addition of ramucirumab to docetaxel in HER@-negative advanced breast cancer did not meaningfully improve important clinical outcomes .", "sentence_id": 11}
+{"abstract_id": "25391692", "label": "background", "text": "The Focused Abdominal Sonography in Trauma ( FAST ) scan is used to detect free fluid in the peritoneal cavity , or pericardium , to quickly assess for injuries needing immediate surgical intervention .", "sentence_id": 0}
+{"abstract_id": "25391692", "label": "background", "text": "Mass-casualty incidents ( MCIs ) are settings where paramedics must make triage decisions in minutes .", "sentence_id": 1}
+{"abstract_id": "25391692", "label": "background", "text": "The Simple Triage and Rapid Transport ( START ) system is used to prioritize transport .", "sentence_id": 2}
+{"abstract_id": "25391692", "label": "background", "text": "The FAST scan can be added to the triage of critical patients , and may aid in triage .", "sentence_id": 3}
+{"abstract_id": "25391692", "label": "methods", "text": "This was a single-blinded , randomized control trial .", "sentence_id": 4}
+{"abstract_id": "25391692", "label": "methods", "text": "Ten paramedics with field experience were trained with an ultrasound machine in the performance of the FAST scan .", "sentence_id": 5}
+{"abstract_id": "25391692", "label": "methods", "text": "Two weeks were allowed to pass before testing to simulate the time between training of standard procedures and their implementation .", "sentence_id": 6}
+{"abstract_id": "25391692", "label": "methods", "text": "On test day , five peritoneal dialysis patients with instilled dialysis fluid and five matched control patients were placed in a room in a random order where the paramedics performed FAST scans on each patient .", "sentence_id": 7}
+{"abstract_id": "25391692", "label": "methods", "text": "The paramedics were assessed by declaring positive or negative for each evaluation , as well as being timed for the total exercise .", "sentence_id": 8}
+{"abstract_id": "25391692", "label": "results", "text": "Of the ninety tests ( one paramedic dropped out due to family emergency ) , the paramedics had a mean accuracy of @ % and median of @ % ( range @ % -@ % ) .", "sentence_id": 9}
+{"abstract_id": "25391692", "label": "results", "text": "There was a statistically significant higher false-positive rate of @ % than false-negative rate of @ % ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25391692", "label": "results", "text": "Sensitivity was @ % with a specificity of @ % .", "sentence_id": 11}
+{"abstract_id": "25391692", "label": "results", "text": "Average time taken was @,@ seconds ( @ seconds per patient ) with a range of @-@ ,@ seconds and a median of @,@ seconds .", "sentence_id": 12}
+{"abstract_id": "25391692", "label": "conclusions", "text": "In this simulation study , paramedics had difficulty performing FAST scans with a high degree of accuracy .", "sentence_id": 13}
+{"abstract_id": "25391692", "label": "conclusions", "text": "However , they were more apt to call a patient positive , limiting the likelihood for false-negative triage .", "sentence_id": 14}
+{"abstract_id": "25077601", "label": "objective", "text": "To investigate the role of Platelet Activating Factor ( PAF ) in the pathogenesis and development of Age-Related Macular Degeneration ( ARMD ) .", "sentence_id": 0}
+{"abstract_id": "25077601", "label": "methods", "text": "Fifty six patients with ARMD ( @ patients with dry ARMD and @ patients with wet ARMD ) and @ age-matched control participants underwent ophthalmological examination , including visual acuity measurement and evaluation of the retina .", "sentence_id": 1}
+{"abstract_id": "25077601", "label": "methods", "text": "The participants were classified into three groups according to their retinal status , based on indirect fundoscopy , Optical Coherence Tomography and fluorescein angiography findings .", "sentence_id": 2}
+{"abstract_id": "25077601", "label": "methods", "text": "In order to evaluate the concentrations of PAF in serum , blood samples were collected from all participants and were analyzed with ELISA technique .", "sentence_id": 3}
+{"abstract_id": "25077601", "label": "results", "text": "The concentrations of PAF differed significantly according to macular lesions and were found to be lower in patients with ARMD than control participants .", "sentence_id": 4}
+{"abstract_id": "25077601", "label": "conclusions", "text": "PAF levels are decreased along with the severity of ARMD .", "sentence_id": 5}
+{"abstract_id": "25077601", "label": "conclusions", "text": "Understanding the role of PAF in pathogenesis of ARMD could be the impetus for the development of new therapies field of treatment of ARMD or even other retinal diseases .", "sentence_id": 6}
+{"abstract_id": "24618837", "label": "background", "text": "In a previous UK multi-center randomized study @ children received three doses of @-valent ( PCV-@ ) or @-valent ( PCV-@ ) pneumococcal conjugate vaccine at @ , @ and @ months of age .", "sentence_id": 0}
+{"abstract_id": "24618837", "label": "background", "text": "At @ months of age , most of these children had pneumococcal serotype-specific IgG concentrations @ g/ml and opsonophagocytic assay ( OPA ) titers @ .", "sentence_id": 1}
+{"abstract_id": "24618837", "label": "methods", "text": "Children who had participated in the original study were enrolled again at @ years of age .", "sentence_id": 2}
+{"abstract_id": "24618837", "label": "methods", "text": "Persistence of immunity following infant immunization with either PCV-@ or PCV-@ and the immune response to a PCV-@ booster at pre-school age were investigated .", "sentence_id": 3}
+{"abstract_id": "24618837", "label": "results", "text": "In total , @ children were followed-up to the age of @ years and received a PCV-@ booster at this age .", "sentence_id": 4}
+{"abstract_id": "24618837", "label": "results", "text": "At least @ % of children who received PCV-@ or PCV-@ in infancy retained serotype-specific IgG concentrations @ g/ml against each of @/@ shared serotypes .", "sentence_id": 5}
+{"abstract_id": "24618837", "label": "results", "text": "For serotypes @ and @C , persistence was lower at @-@ % .", "sentence_id": 6}
+{"abstract_id": "24618837", "label": "results", "text": "At least @ % of PCV-@ group participants had IgG concentrations @ g/ml against each of @/@ of the additional PCV-@ serotypes ; for serotypes @ and @ this proportion was @ % and @ % .", "sentence_id": 7}
+{"abstract_id": "24618837", "label": "results", "text": "In the PCV-@ group these percentages were significantly lower for serotypes @ , @ and @F .", "sentence_id": 8}
+{"abstract_id": "24618837", "label": "results", "text": "A pre-school PCV-@ booster was highly immunogenic and resulted in low rates of local and systemic adverse effects .", "sentence_id": 9}
+{"abstract_id": "24618837", "label": "conclusions", "text": "Despite some decline in antibody from @ months of age , these data suggest that a majority of pre-school children maintain protective serotype-specific antibody concentrations following conjugate vaccination at @ , @ and @ months of age .", "sentence_id": 10}
+{"abstract_id": "24468068", "label": "background", "text": "Asymmetric movements with both hands contributed to the improvement of spatially coupled motion .", "sentence_id": 0}
+{"abstract_id": "24468068", "label": "background", "text": "Thus , the aim of this study was to investigate the effects of an asymmetric training program using virtual reality reflection equipment on upper limb function in stroke patients .", "sentence_id": 1}
+{"abstract_id": "24468068", "label": "methods", "text": "Twenty-four stroke patients were randomly allocated to an experimental group ( n = @ ) or a control group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24468068", "label": "methods", "text": "Both groups participated in conventional physical therapy for @ min/d , @ d/wk , for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24468068", "label": "methods", "text": "The experimental group also participated in an asymmetric training program using virtual reality reflection equipment , and the control group participated in a symmetric training program .", "sentence_id": 4}
+{"abstract_id": "24468068", "label": "methods", "text": "Both asymmetric and symmetric programs were conducted for @ min/d , @ d/wk , for @ weeks .", "sentence_id": 5}
+{"abstract_id": "24468068", "label": "methods", "text": "To compare upper limb function before and after intervention , the Fugl-Meyer Assessment ( FMA ) , the Box and Block Test ( BBT ) , grip strength , range of motion ( ROM ) , and spasticity were assessed .", "sentence_id": 6}
+{"abstract_id": "24468068", "label": "results", "text": "Both groups showed significant increases in upper limb function , excepting spasticity , after intervention ( P < @ , @-way repeated-measures analysis of variance -LSB- ANOVA -RSB- ) .", "sentence_id": 7}
+{"abstract_id": "24468068", "label": "results", "text": "A significant group-time interaction was demonstrated only for shoulder/elbow/wrist items of FMA , BBT , grip strength , and ROM of wrist flexion , extension , and ulnar deviation ( P < @ , @-way repeated-measures ANOVA ) .", "sentence_id": 8}
+{"abstract_id": "24468068", "label": "conclusions", "text": "This study confirms that the asymmetric training program using virtual reality reflection equipment is an effective intervention method for improving upper limb function in stroke patients .", "sentence_id": 9}
+{"abstract_id": "24468068", "label": "conclusions", "text": "We consider that an additional study based on a program using virtual reflection , which is more functional than performing simple tasks , and consisting of tasks relevant to the activities of daily living be conducted .", "sentence_id": 10}
+{"abstract_id": "25000552", "label": "objective", "text": "We aimed to evaluate the clinical efficacy of ciprofloxacin plus fluocinolone acetonide ( antibiotic plus corticosteroid ) ear drops compared to ciprofloxacin ( antibiotic ) ear drops in diffuse otitis externa .", "sentence_id": 0}
+{"abstract_id": "25000552", "label": "methods", "text": "This was a multicentre , randomised , parallel-group , double-blind study involving @ patients of both sexes aged @years or older .", "sentence_id": 1}
+{"abstract_id": "25000552", "label": "results", "text": "The rate of clinical cure was higher ( p = @ ) with ciprofloxacin plus fluocinolone acetonide than with ciprofloxacin alone .", "sentence_id": 2}
+{"abstract_id": "25000552", "label": "results", "text": "The mean total symptom score was lower with ciprofloxacin plus fluocinolone acetonide ( p = @ ) .", "sentence_id": 3}
+{"abstract_id": "25000552", "label": "results", "text": "No differences were found in the percentage of patients reporting resolution of otalgia between patients receiving ciprofloxacin plus fluocinolone acetonide and patients receiving only ciprofloxacin .", "sentence_id": 4}
+{"abstract_id": "25000552", "label": "results", "text": "Resolution of oedema and otorrhoea ( p = @ and p = @ , respectively ) was higher with ciprofloxacin plus fluocinolone acetonide , as was eradication or presumed eradication ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25000552", "label": "results", "text": "There were eight mild adverse events , three with the ciprofloxacin plus fluocinolone acetonide combination ( not related to the treatment ) and five when ciprofloxacin was administered alone ( directly related to the treatment ) .", "sentence_id": 6}
+{"abstract_id": "25000552", "label": "conclusions", "text": "Ciprofloxacin plus fluocinolone acetonide is a more effective treatment for diffuse otitis externa than ciprofloxacin alone .", "sentence_id": 7}
+{"abstract_id": "25000552", "label": "conclusions", "text": "The ciprofloxacin plus fluocinolone acetonide combination also has an excellent safety profile .", "sentence_id": 8}
+{"abstract_id": "24912653", "label": "background", "text": "Prophylactic use of fresh-frozen plasma ( FFP ) is common practice in patients with a coagulopathy undergoing an invasive procedure .", "sentence_id": 0}
+{"abstract_id": "24912653", "label": "background", "text": "Evidence that FFP prevents bleeding is lacking , while risks of transfusion-related morbidity after FFP have been well demonstrated .", "sentence_id": 1}
+{"abstract_id": "24912653", "label": "background", "text": "We aimed to assess whether omitting prophylactic FFP transfusion in nonbleeding critically ill patients with a coagulopathy who undergo an intervention is noninferior to a prophylactic transfusion of FFP .", "sentence_id": 2}
+{"abstract_id": "24912653", "label": "methods", "text": "A multicenter randomized open-label trial with blinded endpoint evaluation was performed in critically ill patients with a prolonged international normalized ratio ( INR ; @-@ @ ) .", "sentence_id": 3}
+{"abstract_id": "24912653", "label": "methods", "text": "Patients undergoing placement of a central venous catheter , percutaneous tracheostomy , chest tube , or abscess drainage were eligible .", "sentence_id": 4}
+{"abstract_id": "24912653", "label": "methods", "text": "Patients with clinically overt bleeding , thrombocytopenia , or therapeutic use of anticoagulants were excluded .", "sentence_id": 5}
+{"abstract_id": "24912653", "label": "methods", "text": "Patients were randomly assigned to omitting or administering a prophylactic transfusion of FFP ( @mL/kg ) .", "sentence_id": 6}
+{"abstract_id": "24912653", "label": "methods", "text": "Outcomes were occurrence of postprocedural bleeding complications , INR correction , and occurrence of lung injury .", "sentence_id": 7}
+{"abstract_id": "24912653", "label": "results", "text": "Due to slow inclusion , the trial was stopped before the predefined target enrollment was reached .", "sentence_id": 8}
+{"abstract_id": "24912653", "label": "results", "text": "Eighty-one patients were randomly assigned , @ to FFP and @ to no FFP transfusion .", "sentence_id": 9}
+{"abstract_id": "24912653", "label": "results", "text": "Incidence of bleeding did not differ between groups , with a total of one major and @ minor bleedings ( p = @ for noninferiority ) .", "sentence_id": 10}
+{"abstract_id": "24912653", "label": "results", "text": "FFP transfusion resulted in a reduction of INR to less than @ in @ % of transfused patients .", "sentence_id": 11}
+{"abstract_id": "24912653", "label": "results", "text": "No differences in lung injury scores were observed .", "sentence_id": 12}
+{"abstract_id": "24912653", "label": "conclusions", "text": "In critically ill patients undergoing an invasive procedure , no difference in bleeding complications was found regardless whether FFP was prophylactically administered or not .", "sentence_id": 13}
+{"abstract_id": "25194085", "label": "objective", "text": "Chronic bacterial prostatitis displays a variety of symptoms ( mainly local pain exhibiting variability in origin and intensity ) .", "sentence_id": 0}
+{"abstract_id": "25194085", "label": "objective", "text": "These symptoms often persist despite bacterial eradication .", "sentence_id": 1}
+{"abstract_id": "25194085", "label": "objective", "text": "The purpose of this article is to exam the role of phytotherapeutic agents as complementary treatment in patients with bacterial prostatitis .", "sentence_id": 2}
+{"abstract_id": "25194085", "label": "methods", "text": "The material consisted of individuals with reported pelvic discomfort and genital pain with or without lower urinary tract symptoms ( LUTS ) and sexual dysfunction visiting our department from March @ to March @ .", "sentence_id": 3}
+{"abstract_id": "25194085", "label": "methods", "text": "Patients underwent Stamey-Meares test ( several cases underwent the two glass test ) .", "sentence_id": 4}
+{"abstract_id": "25194085", "label": "methods", "text": "Depending on history and specific symptoms urethral smear and semen cultures were additionally obtained from several patients .", "sentence_id": 5}
+{"abstract_id": "25194085", "label": "methods", "text": "All patients were randomized into two groups .", "sentence_id": 6}
+{"abstract_id": "25194085", "label": "methods", "text": "Subjects in the first group ( @ patients ) received appropriate antibiotic ( according to the sensitivity test ) for @ days , while subjects in the second group ( @ patients ) received phytotherapeutic agents for @ days , additionally the conventional @ days antibiotic treatment .", "sentence_id": 7}
+{"abstract_id": "25194085", "label": "methods", "text": "The response was tested using laboratory and clinical criteria .", "sentence_id": 8}
+{"abstract_id": "25194085", "label": "results", "text": "We found no statistically significant differences between the two groups regarding bacterial and symptom persistence rate , however , symptoms burden was lower in patients receiving combinational treatment .", "sentence_id": 9}
+{"abstract_id": "25194085", "label": "conclusions", "text": "Phytotherapeutic agents may improve pain and prostatitis related difficulty in urination .", "sentence_id": 10}
+{"abstract_id": "25194085", "label": "conclusions", "text": "Further randomized , placebo-controlled studies are needed to substantiate safer conclusions .", "sentence_id": 11}
+{"abstract_id": "24228532", "label": "objective", "text": "To observe the effect and safety of Xiaozhi particles , integrated taohong Siwu tang and Erchen tang and Xuezhikang capsule in treating hyperlipidaemia ( HLP ) associated with highly active antiretroviral therapy ( HAART ) .", "sentence_id": 0}
+{"abstract_id": "24228532", "label": "methods", "text": "In the multi-centered , randomized controlled clinical study , @ hyperlipidaemia associated with highly active antiretroviral therapy cases were divided into the treatment group treated by Xiaozhi particles , integrated Taohong Siwu tang and Erchen tang , and the control group treated by Xuezhikang capsule .", "sentence_id": 1}
+{"abstract_id": "24228532", "label": "methods", "text": "The treatment course was @ weeks .", "sentence_id": 2}
+{"abstract_id": "24228532", "label": "methods", "text": "The total cholesterol ( Tch ) , triglyceride ( TG ) , low density lipoprotein ( LDL ) and high-density lipoprotein ( HDL ) were observed .", "sentence_id": 3}
+{"abstract_id": "24228532", "label": "results", "text": "After @ weeks , compared with Xuezhikang capsule , the change difference of Tch , LDL , HDL in the Chinese traditional medicine formula groups of patients is significant ( P < @ ) , the change of the TG has no significant difference .", "sentence_id": 4}
+{"abstract_id": "24228532", "label": "results", "text": "The effect of Tch , LDL in Xuezhikang capsule groups is better than in traditional Chinese medicine formula group , but the effect of HDL in traditional Chinese medicine formula group is better than in Xuezhikang capsule groups .", "sentence_id": 5}
+{"abstract_id": "24228532", "label": "conclusions", "text": "Integrated Taohong Siwu tang and Erchen tang , Xiaozhi particles and Xuezhikang capsule can be used to control the hyperlipidaemia associated with highly active antiretroviral therapy as one of the main Chinese native medicine preparation .", "sentence_id": 6}
+{"abstract_id": "25006118", "label": "background", "text": "Primary care is an ideal setting to treat pediatric obesity .", "sentence_id": 0}
+{"abstract_id": "25006118", "label": "background", "text": "Effective , low-intensity ( @ contact hours over @ months ) interventions that reduce standardized body mass index ( z-BMI ) and can be delivered by primary care providers are needed .", "sentence_id": 1}
+{"abstract_id": "25006118", "label": "objective", "text": "This pilot randomized controlled trial investigated the effect of @ low-intensity ( @ contact hours over @ months ) pediatric obesity treatments on z-BMI .", "sentence_id": 2}
+{"abstract_id": "25006118", "label": "methods", "text": "Twenty-two families ( children @ @ years , z-BMI of @ @ ) were randomized into @ of @ , @-month , low-intensity conditions : newsletter ( N ) , newsletter and growth monitoring ( N + GM ) , or newsletter and growth monitoring plus family-based behavioral counseling ( N + GM + BC ) .", "sentence_id": 3}
+{"abstract_id": "25006118", "label": "methods", "text": "Anthropometrics and child eating and leisure-time behaviors were measured .", "sentence_id": 4}
+{"abstract_id": "25006118", "label": "results", "text": "Mixed-factor analyses of variance found a significant ( P < @ ) main effect of time for z-BMI and servings per day of sugar sweetened beverages , with both decreasing over time .", "sentence_id": 5}
+{"abstract_id": "25006118", "label": "conclusions", "text": "Low-intensity obesity treatments can reduce z-BMI and may be more feasible in primary care .", "sentence_id": 6}
+{"abstract_id": "24418801", "label": "objective", "text": "To evaluate the efficacy of low-level laser therapy ( LLLT ) applied to acupuncture points on the knee joint in combination with exercise and advice in patients with knee osteoarthritis .", "sentence_id": 0}
+{"abstract_id": "24418801", "label": "methods", "text": "Randomised , double-blind , comparative clinical trial .", "sentence_id": 1}
+{"abstract_id": "24418801", "label": "methods", "text": "Forty-nine patients with knee osteoarthritis were assigned at random into two groups : active laser group ( n = @ ) and placebo laser group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24418801", "label": "methods", "text": "Using a gallium aluminium arsenide laser device , patients received either active or placebo LLLT at five acupuncture points on the affected knee during nine sessions .", "sentence_id": 3}
+{"abstract_id": "24418801", "label": "methods", "text": "Patients were assessed using a visual analogue scale ( VAS ) and the Saudi Knee Function Scale ( SKFS ) at baseline , the fifth treatment session , the last treatment session , @ weeks post intervention and @ months post intervention .", "sentence_id": 4}
+{"abstract_id": "24418801", "label": "results", "text": "VAS scores showed a significant improvement in the active laser group compared with the placebo laser group at @ weeks post intervention -LSB- mean difference -@ , @ % confidence interval ( CI ) of the difference -@ to -@ ; P = @ -RSB- and @ months post intervention ( mean difference -@ , @ % CI of the difference -@ to -@ ; P = @ ) using the independent samples test .", "sentence_id": 5}
+{"abstract_id": "24418801", "label": "results", "text": "SKFS scores also showed a significant improvement in the active laser group compared with the placebo laser group at the last treatment session ( median difference -@ , @ % CI of the difference -@ to -@ ; P = @ ) and @ months post intervention ( median difference -@ , @ % CI of the difference -@ to -@ ; P = @ ) using the Mann-Whitney U test .", "sentence_id": 6}
+{"abstract_id": "24418801", "label": "conclusions", "text": "The results demonstrate that short-term application of LLLT to specific acupuncture points in association with exercise and advice is effective in reducing pain and improving quality of life in patients with knee osteoarthritis .", "sentence_id": 7}
+{"abstract_id": "25574925", "label": "background", "text": "Passive smoking is associated with tuberculosis ( TB ) .", "sentence_id": 0}
+{"abstract_id": "25574925", "label": "background", "text": "Measures are required to protect non-smoking TB patients from second-hand smoke ( SHS ) .", "sentence_id": 1}
+{"abstract_id": "25574925", "label": "methods", "text": "We developed a behavioural intervention to encourage TB patients to implement smoking restrictions at home in Pakistan .", "sentence_id": 2}
+{"abstract_id": "25574925", "label": "objective", "text": "To assess the likelihood of such an intervention being successful and to inform a definitive trial in future .", "sentence_id": 3}
+{"abstract_id": "25574925", "label": "methods", "text": "This was a pilot randomised controlled trial in which non-smoking TB patients were randomised to receive either individual-based support or individual-based support combined with family reminders .", "sentence_id": 4}
+{"abstract_id": "25574925", "label": "methods", "text": "We recruited patients living with at least one smoker in their homes .", "sentence_id": 5}
+{"abstract_id": "25574925", "label": "methods", "text": "Our primary outcome was urinary cotinine level as a measure of SHS exposure @ months post-randomisation .", "sentence_id": 6}
+{"abstract_id": "25574925", "label": "results", "text": "Of @ patients assessed for eligibility , @ ( @ % ) patients were recruited and all but one were retained throughout the trial .", "sentence_id": 7}
+{"abstract_id": "25574925", "label": "results", "text": "A statistically significant absolute reduction was observed in non-smoking participants ' exposure to SHS based on urinary cotinine levels in both Arm @ ( @ % , @ % CI @-@ ) and Arm @ ( @ % , @ % CI @-@ ) between baseline and follow-up at @ months .", "sentence_id": 8}
+{"abstract_id": "25574925", "label": "conclusions", "text": "The recruitment and retention rates for trial participants make it feasible to conduct a definitive trial in future .", "sentence_id": 9}
+{"abstract_id": "25574925", "label": "conclusions", "text": "The observed effect size makes it worthwhile to conduct such a trial .", "sentence_id": 10}
+{"abstract_id": "25085298", "label": "background", "text": "In this study , we aimed to determine the effect of carbon dioxide laser irradiation on enamel surface microhardness .", "sentence_id": 0}
+{"abstract_id": "25085298", "label": "methods", "text": "In this single-blind interventional clinical trial , @ patients needing at least @ premolars extracted for orthodontic purposes participated .", "sentence_id": 1}
+{"abstract_id": "25085298", "label": "methods", "text": "In each subject , @ premolar was treated with the carbon dioxide laser ( beam diameter , @ mm ; power , @ W ) ; the other was exposed to a visible guiding light as the control .", "sentence_id": 2}
+{"abstract_id": "25085298", "label": "methods", "text": "A t-loop was ligated to the bonded brackets to increase caries risk .", "sentence_id": 3}
+{"abstract_id": "25085298", "label": "methods", "text": "After at least @ months , the teeth were extracted , and the surface microhardness was measured .", "sentence_id": 4}
+{"abstract_id": "25085298", "label": "methods", "text": "Scanning electron microscope evaluation was performed on @ sample from each group .", "sentence_id": 5}
+{"abstract_id": "25085298", "label": "methods", "text": "Normal distribution of the data was assessed by the Kolmogorov-Smirnov and Shapiro-Wilks tests .", "sentence_id": 6}
+{"abstract_id": "25085298", "label": "methods", "text": "Mean microhardness values of the @ groups were compared using paired t tests .", "sentence_id": 7}
+{"abstract_id": "25085298", "label": "results", "text": "The data had normal distributions .", "sentence_id": 8}
+{"abstract_id": "25085298", "label": "results", "text": "Means and standard deviations of the microhardness in the laser-treated and control groups were @ @ and @ @ Vickers hardness numbers , respectively ; this was different significantly ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25085298", "label": "results", "text": "Scanning electron microscopy showed the enamel surface melting in the laser-treated specimens .", "sentence_id": 10}
+{"abstract_id": "25085298", "label": "conclusions", "text": "Carbon dioxide laser treatment results in higher enamel surface microhardness around orthodontic brackets .", "sentence_id": 11}
+{"abstract_id": "25085298", "label": "conclusions", "text": "Patients at high risk of caries might benefit from this intervention .", "sentence_id": 12}
+{"abstract_id": "25085298", "label": "conclusions", "text": "Exact control of the laser irradiation parameters is recommended .", "sentence_id": 13}
+{"abstract_id": "24939437", "label": "background", "text": "Down syndrome ( DS ) is the most common human chromosomal abnormality .", "sentence_id": 0}
+{"abstract_id": "24939437", "label": "background", "text": "It is characterized by mental retardation and several metabolic disturbances , including elevated oxidative stress , which may be causally linked .", "sentence_id": 1}
+{"abstract_id": "24939437", "label": "background", "text": "Treatment with dietary antioxidants has been suggested as a potential method to alleviate the oxidative damage and retardation of DS patients , but prior supplementation work has been equivocal .", "sentence_id": 2}
+{"abstract_id": "24939437", "label": "objective", "text": "To evaluate the effects of supplementation with antioxidants - tocopherol and - lipoic acid ( ALA ) on oxidative stress biomarkers in DS children .", "sentence_id": 3}
+{"abstract_id": "24939437", "label": "methods", "text": "Ninety-three DS children aged @-@ years from both sexes were randomly allocated to three groups : - tocopherol ( @ IU/day ) , ALA ( @mg/day ) and placebo .", "sentence_id": 4}
+{"abstract_id": "24939437", "label": "methods", "text": "The intervention period was @ months .", "sentence_id": 5}
+{"abstract_id": "24939437", "label": "methods", "text": "A healthy control group consisted @ non-DS siblings .", "sentence_id": 6}
+{"abstract_id": "24939437", "label": "methods", "text": "Serum thiobarbituric acid reactive substances ( TBARS ) and urinary @-hydroxy-@ ' - deoxyguanosine ( @OHdG ) were used as biomarkers of oxidative stress .", "sentence_id": 7}
+{"abstract_id": "24939437", "label": "results", "text": "DS children had greater levels of baseline oxidative stress than their siblings .", "sentence_id": 8}
+{"abstract_id": "24939437", "label": "results", "text": "Moreover , males had greater levels of @OHdG than females ( P < @ ) but there was no significant association between age and biomarkers of oxidative stress .", "sentence_id": 9}
+{"abstract_id": "24939437", "label": "results", "text": "Serum levels of TBARS did not change significantly over time , or relative to placebo .", "sentence_id": 10}
+{"abstract_id": "24939437", "label": "results", "text": "Although urinary @OHdG concentrations decreased significantly in both - tocopherol and ALA , groups compared with the baseline levels ( P < @ ) , mean final levels of urinary @OHdG concentrations differed significantly only between - tocopherol and placebo groups ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24939437", "label": "conclusions", "text": "- Tocopherol supplementation of the diets of DS children may attenuate oxidative stress at the DNA level .", "sentence_id": 12}
+{"abstract_id": "25281275", "label": "background", "text": "The only subgroups of patients with heart failure and atrial fibrillation in which the efficacy of cardiac resynchronization therapy has been scientifically proven are patients with indications for right ventricular pacing and patients after atrioventricular junction ablation .", "sentence_id": 0}
+{"abstract_id": "25281275", "label": "background", "text": "However it is unlikely that atrioventricular junction ablation would be a standard procedure in the majority of the heart failure patients with cardiac resynchronization therapy and concomitant atrial fibrillation due to the irreversible character of the procedure and a spontaneous sinus rhythm resumption that occurs in about @ % of these patients .", "sentence_id": 1}
+{"abstract_id": "25281275", "label": "methods", "text": "Pilot-CRAfT is the first randomized controlled trial evaluating the efficacy of a rhythm control strategy in atrial fibrillation patients with cardiac resynchronization therapy devices .", "sentence_id": 2}
+{"abstract_id": "25281275", "label": "methods", "text": "The aim of this prospective , single center randomized controlled pilot study is to answer the question whether the patients with cardiac resynchronization therapy and permanent atrial fibrillation would benefit from a strategy to restore and maintain sinus rhythm ( that is ` rhythm control ' strategy ) in comparison to rate control strategy .", "sentence_id": 3}
+{"abstract_id": "25281275", "label": "methods", "text": "The study population consists of @ patients with heart failure and concomitant long-standing persistent or permanent atrial fibrillation who underwent a cardiac resynchronization therapy device implantation at least @ months before qualification .", "sentence_id": 4}
+{"abstract_id": "25281275", "label": "methods", "text": "Study participants are randomly assigned to the rhythm control strategy ( including electrical cardioversion and pharmacotherapy ) or to the rate control group whose goal is to control ventricular rate .", "sentence_id": 5}
+{"abstract_id": "25281275", "label": "methods", "text": "The follow-up time is @ months .", "sentence_id": 6}
+{"abstract_id": "25281275", "label": "methods", "text": "The primary endpoint is the ratio of effectively captured biventricular beats .", "sentence_id": 7}
+{"abstract_id": "25281275", "label": "methods", "text": "The secondary endpoints include peak oxygen consumption , six-minute walk test distance , heart failure symptom escalation , reverse remodelling of the heart on echo and quality of life .", "sentence_id": 8}
+{"abstract_id": "25583139", "label": "background", "text": "The American Heart Association has defined a new metric of ideal cardiovascular health as part of its @ Impact Goals .", "sentence_id": 0}
+{"abstract_id": "25583139", "label": "background", "text": "We examined whether psychosocial factors in youth predict ideal cardiovascular health in adulthood .", "sentence_id": 1}
+{"abstract_id": "25583139", "label": "results", "text": "Participants were @ men and @ women from the nationwide Cardiovascular Risk in Young Finns Study .", "sentence_id": 2}
+{"abstract_id": "25583139", "label": "results", "text": "Psychosocial factors were measured from cohorts @ to @ years of age at the baseline of the study , and ideal cardiovascular health was examined @ years later in adulthood .", "sentence_id": 3}
+{"abstract_id": "25583139", "label": "results", "text": "The summary measure of psychosocial factors in youth comprised socioeconomic factors , emotional factors , parental health behaviors , stressful events , self-regulation of the child , and social adjustment of the child .", "sentence_id": 4}
+{"abstract_id": "25583139", "label": "results", "text": "There was a positive association between a higher number of favorable psychosocial factors in youth and greater ideal cardiovascular health index in adulthood ( = @ ; P < @ ) that persisted after adjustment for age , sex , medication use , and cardiovascular risk factors in childhood ( = @ ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25583139", "label": "results", "text": "The association was monotonic , suggesting that each increment in favorable psychosocial factors was associated with improvement in cardiovascular health .", "sentence_id": 6}
+{"abstract_id": "25583139", "label": "results", "text": "Of the specific psychosocial factors , a favorable socioeconomic environment ( = @ ; P < @ ) and participants ' self-regulatory behavior ( = @ ; P = @ ) were the strongest predictors of ideal cardiovascular health in adulthood .", "sentence_id": 7}
+{"abstract_id": "25583139", "label": "conclusions", "text": "The findings suggest a dose-response association between favorable psychosocial factors in youth and cardiovascular health in adulthood , as defined by the American Heart Association metrics .", "sentence_id": 8}
+{"abstract_id": "25583139", "label": "conclusions", "text": "The effect seems to persist throughout the range of cardiovascular health , potentially shifting the population distribution of cardiovascular health rather than simply having effects in a high-risk population .", "sentence_id": 9}
+{"abstract_id": "25295434", "label": "objective", "text": "Effects of depression treatment are obscured by heterogeneity among patients .", "sentence_id": 0}
+{"abstract_id": "25295434", "label": "objective", "text": "Personality types could be one source of heterogeneity that explains variability in treatment response .", "sentence_id": 1}
+{"abstract_id": "25295434", "label": "objective", "text": "Clinically meaningful variations in personality patterns could be captured with data-driven subgroups .", "sentence_id": 2}
+{"abstract_id": "25295434", "label": "objective", "text": "The aim of this study was to identify such personality types and to explore their predictive value for treatment efficacy .", "sentence_id": 3}
+{"abstract_id": "25295434", "label": "methods", "text": "Participants ( N = @ ) in the current exploratory study came from a randomized controlled trial in primary care depressed patients , conducted between January @ and June @ , comparing different treatments .", "sentence_id": 4}
+{"abstract_id": "25295434", "label": "methods", "text": "All participants were diagnosed with a major depressive disorder ( MDD ) according to the DSM-IV .", "sentence_id": 5}
+{"abstract_id": "25295434", "label": "methods", "text": "Primary ( care as usual -LSB- CAU -RSB- or CAU plus a psychoeducational prevention program -LSB- PEP -RSB- ) and specialized ( CAU + PEP + psychiatric consultation or cognitive-behavioral therapy ) treatment were compared .", "sentence_id": 6}
+{"abstract_id": "25295434", "label": "methods", "text": "Personality was assessed with the Neuroticism-Extraversion-Openness Five-Factor Inventory ( NEO-FFI ) .", "sentence_id": 7}
+{"abstract_id": "25295434", "label": "methods", "text": "Personality classes were identified with latent profile analysis ( LPA ) .", "sentence_id": 8}
+{"abstract_id": "25295434", "label": "methods", "text": "During @ year , weekly depression ratings were obtained by trimonthly assessment with the Composite International Diagnostic Interview .", "sentence_id": 9}
+{"abstract_id": "25295434", "label": "methods", "text": "Mixed models were used to analyze the effects of personality on treatment efficacy .", "sentence_id": 10}
+{"abstract_id": "25295434", "label": "results", "text": "A @-class LPA solution fit best to the NEO-FFI data : Class @ ( vulnerable , n = @ ) was characterized by high neuroticism , low extraversion , and low conscientiousness , and Class @ ( resilient , n = @ ) by medium neuroticism and extraversion and higher agreeableness and conscientiousness .", "sentence_id": 11}
+{"abstract_id": "25295434", "label": "results", "text": "Recovery was quicker in the resilient class ( class time : P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25295434", "label": "results", "text": "Importantly , specialized treatment had added value only in the vulnerable class , in which it was associated with quicker recovery than primary treatment ( class time treatment : P < @ ) .", "sentence_id": 13}
+{"abstract_id": "25295434", "label": "conclusions", "text": "Personality profile may predict whether specialized clinical efforts have added value , showing potential implications for planning of treatments .", "sentence_id": 14}
+{"abstract_id": "25429421", "label": "objective", "text": "Selective laser trabeculoplasty ( SLT ) should be explored as a therapeutic option in eyes with angle closure .", "sentence_id": 0}
+{"abstract_id": "25429421", "label": "objective", "text": "To assess the intraocular pressure ( IOP ) - lowering efficacy of SLT in eyes with primary angle closure ( PAC ) and PAC glaucoma ( PACG ) .", "sentence_id": 1}
+{"abstract_id": "25429421", "label": "methods", "text": "Randomized clinical trial at tertiary eye care institutions of @ patients diagnosed as having PAC or PAC glaucoma in which the angles had opened at least @ ( visible posterior trabecular meshwork on gonioscopy ) after laser iridotomy .", "sentence_id": 2}
+{"abstract_id": "25429421", "label": "methods", "text": "Recruitment and baselinewere completed from June @ to April @ and @-month follow-up was completed from December @ to November @ .", "sentence_id": 3}
+{"abstract_id": "25429421", "label": "methods", "text": "Eligible patients with a baseline IOP greater than @ mm Hg were randomized to either SLT or prostaglandin analog ( PGA ; travoprost , @ % ) .", "sentence_id": 4}
+{"abstract_id": "25429421", "label": "methods", "text": "The SLT was repeated if the IOP reduction was less than @ % from baseline at the @ - or @-month follow-up visit .", "sentence_id": 5}
+{"abstract_id": "25429421", "label": "methods", "text": "The primary outcome measure was the change in IOP from baseline to the final follow-up visit ( at @ months ) .", "sentence_id": 6}
+{"abstract_id": "25429421", "label": "methods", "text": "The frequency of additional postoperative treatments and complications were secondary outcomes .", "sentence_id": 7}
+{"abstract_id": "25429421", "label": "results", "text": "Fifty patients ( @ eyes ) were randomized to SLT and @ patients ( @ eyes ) to PGA medical therapy .", "sentence_id": 8}
+{"abstract_id": "25429421", "label": "results", "text": "At @ months , @ patients in the SLT group and @ in the PGA group completed follow-up .", "sentence_id": 9}
+{"abstract_id": "25429421", "label": "results", "text": "Analysis was based on intent to treat .", "sentence_id": 10}
+{"abstract_id": "25429421", "label": "results", "text": "At @ months , IOP decreased by @ mm Hg ( @ % CI , @-@ @ ) in the SLT group ( P < @ ) and by @ mm Hg ( @ % CI , @-@ @ ) in the PGA group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25429421", "label": "results", "text": "There were no differences between the SLT and PGA groups in the absolute mean reduction of IOP ( @ vs @ mm Hg , respectively ; P = @ ) or in the percentage of reduction in IOP ( @ % vs @ % , respectively ; P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25429421", "label": "results", "text": "Complete success ( IOP @ mm Hg without medications ) was achieved in @ % eyes of the SLT group , compared with @ % of eyes in the PGA group ( P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25429421", "label": "results", "text": "No patients required glaucoma surgery .", "sentence_id": 14}
+{"abstract_id": "25429421", "label": "results", "text": "Additional medications were required in @ % of patients in the SLT group compared with @ % in the PGA group ( P = @ ) .", "sentence_id": 15}
+{"abstract_id": "25429421", "label": "results", "text": "One patient in the SLT group ( @ % ) had a transient posttreatment IOP spike greater than @ mm Hg .", "sentence_id": 16}
+{"abstract_id": "25429421", "label": "results", "text": "The mean endothelial cell count showed a significant decrease from baseline in the SLT arm ( @ % decrease ; P = @ ) .", "sentence_id": 17}
+{"abstract_id": "25429421", "label": "results", "text": "No other events such as persistent uveitis or increase in peripheral anterior synechiae were noted in eyes that underwent SLT .", "sentence_id": 18}
+{"abstract_id": "25429421", "label": "results", "text": "Two patients in the PGA group exited owing to drug-related complications ( @ patient with uveitis and @ with allergic conjunctivitis ) .", "sentence_id": 19}
+{"abstract_id": "25429421", "label": "conclusions", "text": "Eyes with PAC or PACG respond to SLT in the short term , but the overall long-term therapeutic effectiveness needs further evaluation .", "sentence_id": 20}
+{"abstract_id": "24404664", "label": "objective", "text": "The antiseptic effectiveness of @ % anerdian III , @ % gentamicin , and @ % tobramycin solutions in pre-surgical irrigation of conjunctival sac were compared .", "sentence_id": 0}
+{"abstract_id": "24404664", "label": "methods", "text": "A total of @ cataract patients ( @ eyes ) who had undergone phacoemulsification aspiration combined with intraocular lens insertion ( IOL ) were recruited in this prospective study .", "sentence_id": 1}
+{"abstract_id": "24404664", "label": "methods", "text": "Operative eyes were given @ % levofloxacin eye drops for @ days and then were randomized into three treatment groups : anerdian ( A ) , gentamicin ( B ) and tobramycin ( C ) .", "sentence_id": 2}
+{"abstract_id": "24404664", "label": "methods", "text": "The patients received conjunctival sac irrigation using the respective solutions at @ minutes preoperatively .", "sentence_id": 3}
+{"abstract_id": "24404664", "label": "methods", "text": "Conjunctival sac sampling was performed before and after irrigation and the samples were used for subsequent bacterial culture and swab tests .", "sentence_id": 4}
+{"abstract_id": "24404664", "label": "methods", "text": "The positive culture rate was used as the main outcome .", "sentence_id": 5}
+{"abstract_id": "24404664", "label": "results", "text": "The positive rates of bacterial culture before conjunctival sac irrigation were @ % ( @ eyes ) in group A , @ % ( @ eyes ) in group B and @ % ( @ eyes ) in group C. Post irrigation , the positive rates in the three groups decreased to @ % ( @ eyes ) , @ % ( @ eyes ) and @ % ( @ eyes ) , respectively .", "sentence_id": 6}
+{"abstract_id": "24404664", "label": "results", "text": "The positive rates among the three groups did not differ significantly .", "sentence_id": 7}
+{"abstract_id": "24404664", "label": "results", "text": "However , the positive rate in group A only significantly differed before and after the irrigation ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24404664", "label": "results", "text": "No toxic or allergic reactions were observed on the ocular surface of any patient after irrigation .", "sentence_id": 9}
+{"abstract_id": "24404664", "label": "conclusions", "text": "The antiseptic effects of the three types of con junctival sac irrigations did not differ .", "sentence_id": 10}
+{"abstract_id": "24490645", "label": "objective", "text": "Observing or hearing about illness in another person can lead to reports of similar symptoms .", "sentence_id": 0}
+{"abstract_id": "24490645", "label": "objective", "text": "Reports can occasionally be widespread .", "sentence_id": 1}
+{"abstract_id": "24490645", "label": "objective", "text": "However , it has been difficult to document whether this is the result of genuine illness or the expression of anxiety with physical terminology .", "sentence_id": 2}
+{"abstract_id": "24490645", "label": "objective", "text": "This study examined the effects of being able to see another blood donor experience vasovagal symptoms .", "sentence_id": 3}
+{"abstract_id": "24490645", "label": "methods", "text": "Data were collected in mobile university blood collection clinics .", "sentence_id": 4}
+{"abstract_id": "24490645", "label": "methods", "text": "Bedside research assistants coded whether the donor was able or not able to see another donor being treated for vasovagal symptoms .", "sentence_id": 5}
+{"abstract_id": "24490645", "label": "methods", "text": "Dependent variables included subjective vasovagal symptoms indicated on the Blood Donation Reactions Inventory ( BDRI ) and the need for treatment oneself .", "sentence_id": 6}
+{"abstract_id": "24490645", "label": "methods", "text": "Given the population of inexperienced donors , many ( @ % of the @,@ participants ) were able to see another donor treated for symptoms .", "sentence_id": 7}
+{"abstract_id": "24490645", "label": "results", "text": "Being able to see another donor treated was associated with higher scores on the BDRI and an increased likelihood of treatment for vasovagal symptoms oneself .", "sentence_id": 8}
+{"abstract_id": "24490645", "label": "results", "text": "However , this was limited to non-first-time blood donors , perhaps because of higher levels in first-time donors ( ceiling effects ) or greater attention to the environment in less `` overwhelmed '' repeat donors .", "sentence_id": 9}
+{"abstract_id": "24490645", "label": "results", "text": "In general , donors who were able to see another react rated themselves as less relaxed and had smaller increases in heart rate .", "sentence_id": 10}
+{"abstract_id": "24490645", "label": "results", "text": "During the @-year follow-up , first-time donors who were able to see another react were slower to return to give blood again .", "sentence_id": 11}
+{"abstract_id": "24490645", "label": "conclusions", "text": "Seeing another donor being treated for symptoms contributed to the vasovagal process in many donors .", "sentence_id": 12}
+{"abstract_id": "24490645", "label": "conclusions", "text": "This environment provides a useful context to study social influences on symptoms and illness .", "sentence_id": 13}
+{"abstract_id": "25163905", "label": "background", "text": "Prostate cancer is a major public health problem with considerable uncertainties about the effectiveness of population screening and treatment options .", "sentence_id": 0}
+{"abstract_id": "25163905", "label": "background", "text": "We report the study design , participant sociodemographic and clinical characteristics , and the initial results of the testing and diagnostic phase of the Prostate testing for cancer and Treatment ( ProtecT ) trial , which aims to investigate the effectiveness of treatments for localised prostate cancer .", "sentence_id": 1}
+{"abstract_id": "25163905", "label": "methods", "text": "In this randomised phase @ trial , men aged @-@ years registered at @ primary care centres in nine UK cities were invited to attend a specialist nurse appointment for a serum prostate-specific antigen ( PSA ) test .", "sentence_id": 2}
+{"abstract_id": "25163905", "label": "methods", "text": "Prostate biopsies were offered to men with a PSA concentration of @ g/L or higher .", "sentence_id": 3}
+{"abstract_id": "25163905", "label": "methods", "text": "Consenting participants with clinically localised prostate cancer were randomly assigned to active monitoring ( surveillance strategy ) , radical prostatectomy , or three-dimensional conformal external-beam radiotherapy by a computer-generated allocation system .", "sentence_id": 4}
+{"abstract_id": "25163905", "label": "methods", "text": "Randomisation was stratified by site ( minimised for differences in participant age , PSA results , and Gleason score ) .", "sentence_id": 5}
+{"abstract_id": "25163905", "label": "methods", "text": "The primary endpoint is prostate cancer mortality at a median @-year follow-up , ascertained by an independent committee , which will be analysed by intention to treat in @ .", "sentence_id": 6}
+{"abstract_id": "25163905", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ , and as an International Standard Randomised Controlled Trial , number ISRCTN@ .", "sentence_id": 7}
+{"abstract_id": "25163905", "label": "results", "text": "Between Oct @ , @ , and Jan @ , @ , @,@ men were invited to attend an appointment with a specialist nurse .", "sentence_id": 8}
+{"abstract_id": "25163905", "label": "results", "text": "Of the invited men , @,@ ( @ % ) attended their initial appointment and @,@ ( @ % ) of attenders had a PSA test .", "sentence_id": 9}
+{"abstract_id": "25163905", "label": "results", "text": "PSA concentration was below the biopsy threshold in @,@ ( @ % ) men .", "sentence_id": 10}
+{"abstract_id": "25163905", "label": "results", "text": "Of the @ men with a PSA concentration of @-@ g/L , @ ( @ % ) underwent biopsies .", "sentence_id": 11}
+{"abstract_id": "25163905", "label": "results", "text": "@ men were diagnosed with prostate cancer ( @ % of tested men and @ % of those who had a biopsy ) , of whom @ ( @ % ) had clinically localised disease ( mostly T@c , Gleason score @ ) .", "sentence_id": 12}
+{"abstract_id": "25163905", "label": "results", "text": "With the addition of @ pilot study participants recruited between @ and @ , @ men were eligible for the treatment trial and @ ( @ % ) agreed to be randomly assigned ( @ to active monitoring , @ to radiotherapy , and @ to radical prostatectomy ) .", "sentence_id": 13}
+{"abstract_id": "25163905", "label": "results", "text": "Clinical and sociodemographic characteristics of randomly assigned participants were balanced across treatment groups .", "sentence_id": 14}
+{"abstract_id": "25163905", "label": "conclusions", "text": "The ProtecT trial randomly assigned @ men with localised prostate cancer to active monitoring , radiotherapy , or surgery .", "sentence_id": 15}
+{"abstract_id": "25163905", "label": "conclusions", "text": "Participant clinicopathological features are more consistent with contemporary patient characteristics than in previous prostate cancer treatment trials .", "sentence_id": 16}
+{"abstract_id": "25591992", "label": "objective", "text": "We examined the therapeutic effects of avanafil @ minutes after dosing in men with mild to severe erectile dysfunction .", "sentence_id": 0}
+{"abstract_id": "25591992", "label": "methods", "text": "This randomized , double-blind , placebo controlled , @-week study ( @-week run-in and @-week treatment ) randomized @ men to placebo , @ to avanafil @ mg and @ to avanafil @ mg on demand .", "sentence_id": 1}
+{"abstract_id": "25591992", "label": "methods", "text": "The primary efficacy variable was the per subject proportion of sexual attempts during the treatment period in which subjects achieved erection sufficient for vaginal penetration within approximately @ minutes after dosing as measured by a stopwatch .", "sentence_id": 2}
+{"abstract_id": "25591992", "label": "methods", "text": "The attempt had to enable successful completion of sexual intercourse according to SEP question @ .", "sentence_id": 3}
+{"abstract_id": "25591992", "label": "results", "text": "Significantly greater mean per subject percentages of successful intercourse attempts within approximately @ minutes after dosing were observed for avanafil @ mg ( mean @ % , LS mean SE @ % @ % ) and @ mg ( mean @ % , LS mean @ % @ % ) vs placebo ( mean @ % , LS mean @ % @ % , p = @ and < @ , respectively ) .", "sentence_id": 4}
+{"abstract_id": "25591992", "label": "results", "text": "After treatment we noted a statistically significant difference between avanafil and placebo in the average per subject proportion of successful intercourse attempts according to SEP question @ as early as @ minutes in the @ mg group and @ minutes in the @ mg group .", "sentence_id": 5}
+{"abstract_id": "25591992", "label": "results", "text": "Treatment emergent adverse events included headache , upper respiratory tract infection and nasal congestion , and most such events were mild or moderate in severity .", "sentence_id": 6}
+{"abstract_id": "25591992", "label": "conclusions", "text": "Avanafil was efficacious within approximately @ minutes of dosing compared to placebo .", "sentence_id": 7}
+{"abstract_id": "25591992", "label": "conclusions", "text": "A statistically significant treatment difference in the percentage of successful sexual attempts was demonstrated as early as @ minutes after treatment .", "sentence_id": 8}
+{"abstract_id": "26160211", "label": "objective", "text": "The objective of this study was to compare the efficacy and comfort of inelastic bandages ( IBs ) and adjustable Velcro compression devices ( AVCDs ) in reducing venous leg edema in the initial treatment phase .", "sentence_id": 0}
+{"abstract_id": "26160211", "label": "methods", "text": "Forty legs from @ patients with untreated venous edema ( C@EpsAsdPr ) were randomized to two groups .", "sentence_id": 1}
+{"abstract_id": "26160211", "label": "methods", "text": "Patients in the first group received IBs ( n = @ ) and those in the second AVCDs ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "26160211", "label": "methods", "text": "Both compression devices were left on the leg day and night , and were renewed after @ day .", "sentence_id": 3}
+{"abstract_id": "26160211", "label": "methods", "text": "Patients in the AVCD group were asked to re-adjust the device as needed when it felt loose .", "sentence_id": 4}
+{"abstract_id": "26160211", "label": "methods", "text": "Leg volume was calculated using the truncated cone formula at baseline ( T@ ) , after @ day ( T@ ) and after @ days ( T@ ) .", "sentence_id": 5}
+{"abstract_id": "26160211", "label": "methods", "text": "The interface pressure of the two compression devices was measured by an air filled probe , and the static stiffness index calculated after applying compression at T@ and T@ , and just before removal of compression on T@ and T@ .", "sentence_id": 6}
+{"abstract_id": "26160211", "label": "methods", "text": "Patient comfort with regard to the two compression systems was assessed by grading signs and symptoms using a visual analog scale .", "sentence_id": 7}
+{"abstract_id": "26160211", "label": "results", "text": "At T@ , the median percent volume reduction was @ % for the IB group versus @ % for the AVCD group ; at T@ it was @ % versus @ % , respectively ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "26160211", "label": "results", "text": "The pressure of the IBs was significantly higher compared with the AVCDs at T@ ( @ vs. @ mmHg ) but dropped by > @ % over time , while it remained unchanged with AVCDs owing to the periodic readjustment by the patient .", "sentence_id": 9}
+{"abstract_id": "26160211", "label": "results", "text": "Comfort was reported to be similar with the two compression devices .", "sentence_id": 10}
+{"abstract_id": "26160211", "label": "conclusions", "text": "Re-adjustable AVCDs with a resting pressure of around @ mmHg are more effective in reducing chronic venous edema than IBs with a resting pressure of around @ mmHg .", "sentence_id": 11}
+{"abstract_id": "26160211", "label": "conclusions", "text": "AVCDs are effective and well tolerated , not only during maintenance therapy , but also in the initial decongestive treatment phase of patients with venous leg edema .", "sentence_id": 12}
+{"abstract_id": "25872782", "label": "background", "text": "Gastroparesis is common in surgical patients and frequently leads to the need for enteral tube feeding .", "sentence_id": 0}
+{"abstract_id": "25872782", "label": "background", "text": "Nasoenteral feeding tubes are usually placed endoscopically by gastroenterologists , but this procedure is relatively cumbersome for patients and labor-intensive for hospital staff .", "sentence_id": 1}
+{"abstract_id": "25872782", "label": "background", "text": "Electromagnetic ( EM ) guided bedside placement of nasoenteral feeding tubes by nurses may reduce patient discomfort , workload and costs , but randomized studies are lacking , especially in surgical patients .", "sentence_id": 2}
+{"abstract_id": "25872782", "label": "background", "text": "We hypothesize that EM guided bedside placement of nasoenteral feeding tubes is at least as effective as endoscopic placement in surgical patients , at lower costs .", "sentence_id": 3}
+{"abstract_id": "25872782", "label": "methods", "text": "The CORE trial is an investigator-initiated , parallel-group , pragmatic , multicenter randomized controlled non-inferiority trial .", "sentence_id": 4}
+{"abstract_id": "25872782", "label": "methods", "text": "A total of @ patients admitted to gastrointestinal surgical wards in five hospitals , requiring nasoenteral feeding , will be randomly allocated to undergo EM guided or endoscopic nasoenteral feeding tube placement .", "sentence_id": 5}
+{"abstract_id": "25872782", "label": "methods", "text": "Primary outcome is reinsertion of the feeding tube , defined as the insertion of an endoscope or tube in the nose/mouth and esophagus for ( re ) placement of the feeding tube ( e.g. after failed initial placement or dislodgement or blockage of the tube ) .", "sentence_id": 6}
+{"abstract_id": "25872782", "label": "methods", "text": "Secondary outcomes include patient-reported outcomes , costs and tube ( placement ) related complications .", "sentence_id": 7}
+{"abstract_id": "25872782", "label": "conclusions", "text": "The CORE trial is designed to generate evidence on the effectiveness of EM guided placement of nasoenteral feeding tubes in surgical patients and the impact on costs as compared to endoscopic placement .", "sentence_id": 8}
+{"abstract_id": "25872782", "label": "conclusions", "text": "The trial potentially offers a strong argument for wider implementation of this technique as method of choice for placement of nasoenteral feeding tubes .", "sentence_id": 9}
+{"abstract_id": "24748161", "label": "background", "text": "The purpose of this study was to describe hospital and geographic variation in @-day risk of surgical complications and death among colorectal cancer ( CRC ) patients and the extent to which patient - , hospital - , and census-tract-level characteristics increased risk of these outcomes .", "sentence_id": 0}
+{"abstract_id": "24748161", "label": "methods", "text": "We included patients at least @years old with first primary stage I-III CRC from the @-@ National Cancer Institute 's Surveillance , Epidemiology , and End Results data linked with @-@ Medicare claims .", "sentence_id": 1}
+{"abstract_id": "24748161", "label": "methods", "text": "A multilevel , cross-classified logistic model was used to account for nesting of patients within hospitals and within residential census tracts .", "sentence_id": 2}
+{"abstract_id": "24748161", "label": "methods", "text": "Outcomes were risk of complications and death after a complication within @days of surgery .", "sentence_id": 3}
+{"abstract_id": "24748161", "label": "results", "text": "Data were analyzed for @,@ patients undergoing surgery at @,@ hospitals and residing in @,@ census tracts ; @ % of patients developed complications , and of these @ % died .", "sentence_id": 4}
+{"abstract_id": "24748161", "label": "results", "text": "Risk-adjusted variability in complications across hospitals and census tracts was similar .", "sentence_id": 5}
+{"abstract_id": "24748161", "label": "results", "text": "Variability in mortality was larger than variability in complications , across hospitals and across census tracts .", "sentence_id": 6}
+{"abstract_id": "24748161", "label": "results", "text": "Specific characteristics increased risk of complications ( e.g. , census-tract-poverty rate , emergency surgery , and being African-American ) .", "sentence_id": 7}
+{"abstract_id": "24748161", "label": "results", "text": "No hospital characteristics increased complication risk .", "sentence_id": 8}
+{"abstract_id": "24748161", "label": "results", "text": "Specific characteristics increased risk of death ( e.g. census-tract-poverty rate , being diagnosed with colon ( versus rectal ) cancer , and emergency surgery ) , while hospitals with at least @ beds showed reduced death risk .", "sentence_id": 9}
+{"abstract_id": "24748161", "label": "conclusions", "text": "Large , unexplained variations exist in mortality after surgical complications in CRC across hospitals and geographic areas .", "sentence_id": 10}
+{"abstract_id": "24748161", "label": "conclusions", "text": "The potential exists for quality improvement efforts targeted at the hospital and/or census-tract levels to prevent complications and augment hospitals ' ability to reduce mortality risk .", "sentence_id": 11}
+{"abstract_id": "25310567", "label": "background", "text": "Clinicians require portable , valid , and cost-effective methods to monitor knee joint-position-sense ( JPS ) ability .", "sentence_id": 0}
+{"abstract_id": "25310567", "label": "objective", "text": "To examine the criterion-related validity of image-capture JPS measures against an isokinetic-dynamometer ( IKD ) procedure .", "sentence_id": 1}
+{"abstract_id": "25310567", "label": "methods", "text": "Random crossover design providing a comparison of knee JPS measures from image capture and IKD procedures .", "sentence_id": 2}
+{"abstract_id": "25310567", "label": "methods", "text": "@ healthy participants , @ female , age @ @ y , mass @ @ kg , height @ @ m , and @ male , @ @ y , mass @ @ kg , height @ @ m.", "sentence_id": 3}
+{"abstract_id": "25310567", "label": "methods", "text": "The dependent variables were absolute error scores ( AES ) provided by @ knee directions ( flexion and extension ) .", "sentence_id": 4}
+{"abstract_id": "25310567", "label": "methods", "text": "The independent variables were the method ( image capture and IKD ) .", "sentence_id": 5}
+{"abstract_id": "25310567", "label": "results", "text": "There was no significant difference between clinical and IKD AES into knee-flexion data ( P = @ , r = @ ) .", "sentence_id": 6}
+{"abstract_id": "25310567", "label": "results", "text": "There was a significant difference between clinical and IKD AES into knee-extension data ( P = @ , r = @ ) .", "sentence_id": 7}
+{"abstract_id": "25310567", "label": "conclusions", "text": "Analysis of photographic images to assess JPS measurements using knee flexion is valid against an IKD positioning method , but JPS measurements using knee extension may not be valid against IKD techniques .", "sentence_id": 8}
+{"abstract_id": "25310567", "label": "conclusions", "text": "However , photo-analysis measurements provided a lower error score using knee-extension data and thus may provide an optimal environment to produce maximal knee JPS acuity .", "sentence_id": 9}
+{"abstract_id": "25310567", "label": "conclusions", "text": "Therefore , clinicians do not need expensive equipment to collect representative JPS ability .", "sentence_id": 10}
+{"abstract_id": "25654309", "label": "background", "text": "Lung volume reduction ( LVR ) techniques improve lung function in selected patients with emphysema , but the impact of LVR procedures on the asynchronous movement of different chest wall compartments , which is a feature of emphysema , is not known .", "sentence_id": 0}
+{"abstract_id": "25654309", "label": "methods", "text": "We used optoelectronic plethysmography to assess the effect of surgical and bronchoscopic LVR on chest wall asynchrony .", "sentence_id": 1}
+{"abstract_id": "25654309", "label": "methods", "text": "Twenty-six patients were assessed before and @ months after LVR ( surgical -LSB- n = @ -RSB- or bronchoscopic -LSB- n = @ -RSB- ) or a sham/unsuccessful bronchoscopic treatment ( control subjects , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25654309", "label": "methods", "text": "Chest wall volumes were divided into six compartments ( left and right of each of pulmonary ribcage -LSB- Vrc , p -RSB- , abdominal ribcage -LSB- Vrc , a -RSB- , and abdomen -LSB- Vab -RSB- ) and phase shift angles ( ) calculated for the asynchrony between Vrc , p and Vrc , a ( RC ) , and between Vrc , a and Vab ( DIA ) .", "sentence_id": 3}
+{"abstract_id": "25654309", "label": "results", "text": "Participants had an FEV of @ @ % predicted and a residual volume of @ @ % predicted with significant chest wall asynchrony during quiet breathing at baseline ( RC , @ @ ; and DIA , -@ @ ) .", "sentence_id": 4}
+{"abstract_id": "25654309", "label": "results", "text": "Between-group difference in the change in RC and DIA during quiet breathing following treatment was @ ( @ % CI , -@ to -@ ; P = @ ) and @ ( @ % CI , @ to @ ; P = @ ) toward @ ( representing perfect synchrony ) , respectively , favoring the LVR group .", "sentence_id": 5}
+{"abstract_id": "25654309", "label": "results", "text": "Changes in RC and DIA were statistically significant on the treated but not the untreated sides .", "sentence_id": 6}
+{"abstract_id": "25654309", "label": "conclusions", "text": "Successful LVR significantly reduces chest wall asynchrony in patients with emphysema .", "sentence_id": 7}
+{"abstract_id": "25658223", "label": "objective", "text": "To assess the impact of passive and active promotional strategies on patient acceptance of medication therapy management ( MTM ) services , and to identify reasons for patient acceptance or refusal .", "sentence_id": 0}
+{"abstract_id": "25658223", "label": "methods", "text": "Four promotional approaches were developed to offer MTM services to eligible patients , including letters and bag stuffers ( `` passive '' approaches ) , and face-to-face offers and telephone calls ( `` active '' approaches ) .", "sentence_id": 1}
+{"abstract_id": "25658223", "label": "methods", "text": "Thirty pharmacies in a grocery store chain were randomized to one of the four approaches .", "sentence_id": 2}
+{"abstract_id": "25658223", "label": "methods", "text": "Patient acceptance rates were compared among the four groups , and between active and passive approaches using hierarchical logistic regression techniques .", "sentence_id": 3}
+{"abstract_id": "25658223", "label": "methods", "text": "Depending on their decision to accept or decline the service , patients were invited to take part in one of two brief telephone surveys .", "sentence_id": 4}
+{"abstract_id": "25658223", "label": "results", "text": "No significant differences were identified among the four promotional methods or between active and passive methods in the analyses .", "sentence_id": 5}
+{"abstract_id": "25658223", "label": "results", "text": "Patients ' most frequent reasons for accepting MTM services were potential cost savings , review of how the medications were working , the expert opinion of the pharmacist , and education about medications .", "sentence_id": 6}
+{"abstract_id": "25658223", "label": "results", "text": "Patients ' most frequent reasons for declining MTM services were that the participant already felt comfortable with their medications and felt their pharmacist provides these services on a regular basis .", "sentence_id": 7}
+{"abstract_id": "25658223", "label": "conclusions", "text": "No significant difference was found among any of the four groups or between active or passive approaches .", "sentence_id": 8}
+{"abstract_id": "25658223", "label": "conclusions", "text": "Further research is warranted to identify strategies for improving patient engagement in MTM services .", "sentence_id": 9}
+{"abstract_id": "25739243", "label": "objective", "text": "To compare the effect on surgical indicators and functional outcome between preoperative skeletal traction and skin traction for adult femoral fracture and guide the choice of preoperative traction method of adult femoral fractures .", "sentence_id": 0}
+{"abstract_id": "25739243", "label": "methods", "text": "From February @ to September @ , @ patients aged greater than @-year-old with femoral fractures were treated and randomly divided into two groups according hospitalization order , the odd with skeletal traction of tibial tubercle ( group A ) and the even with skin traction ( group B ) .", "sentence_id": 1}
+{"abstract_id": "25739243", "label": "methods", "text": "In group A , there were @ males and @ females with an average age of ( @ ) years old , including @ cases with transverse fracture , @ cases with oblique fracture , @ cases with spiral fracture .", "sentence_id": 2}
+{"abstract_id": "25739243", "label": "methods", "text": "In group B , there @ males and @ females with an average age of ( @ ) years old , including @ cases with transverse fracture , @ cases with oblique fracture ,@ cases with spiral fracture .", "sentence_id": 3}
+{"abstract_id": "25739243", "label": "methods", "text": "The operative time , blood loss , the number and amount of blood transfusion , fracture healing time , hemoglobin , pain scores and functional scores between two groups were analyzed and compared .", "sentence_id": 4}
+{"abstract_id": "25739243", "label": "methods", "text": "Results : All patients were followed up , the follow-up time was ( @ ) months in group A , ( @ ) months in groupB .", "sentence_id": 5}
+{"abstract_id": "25739243", "label": "methods", "text": "In group A , the operation time was ( @ ) min and the intraoperative blood loss was ( @ ) ml and the postoperative blood transfusion was @ cases and the blood transfusion was ( @ ) ml and the average bone healing time was ( @ ) weeks .", "sentence_id": 6}
+{"abstract_id": "25739243", "label": "methods", "text": "In group B , the operation time was ( @ ) min and the intraoperative blood loss was ( @ @ ) ml and the blood transfusion was @ cases and the blood transfusion was ( @ ) ml and the average healing time was ( @ ) weeks .", "sentence_id": 7}
+{"abstract_id": "25739243", "label": "methods", "text": "These obseration indicators had no significant difference between two groups .", "sentence_id": 8}
+{"abstract_id": "25739243", "label": "methods", "text": "There was no significant difference between two groups in terms of Hemoglobin , the pain scores before and after traction , the femoral fractures efficacy score , knee function score and knee range .", "sentence_id": 9}
+{"abstract_id": "25739243", "label": "conclusions", "text": "Preoperative skeletal traction does not reduce surgery time , blood loss and pain and so on .", "sentence_id": 10}
+{"abstract_id": "25739243", "label": "conclusions", "text": "The bone healing time and limb functional outcomes were also not significantly improved .", "sentence_id": 11}
+{"abstract_id": "26437529", "label": "objective", "text": "To evaluate the benefit of aromatic therapy using menthol for decrease pain perception during amniocentesis .", "sentence_id": 0}
+{"abstract_id": "26437529", "label": "methods", "text": "A prospective randomized study was conducted to compare pain level between groups ofpregnant women who underwent amniocentesis with and without aromatic therapy using menthol .", "sentence_id": 1}
+{"abstract_id": "26437529", "label": "methods", "text": "Visual analogue scale ( VAS ) was usedfor pain assessment .", "sentence_id": 2}
+{"abstract_id": "26437529", "label": "methods", "text": "The participants were askedfor their anticipated pain and anxiety level and level ofpain before and immediately after the procedure .", "sentence_id": 3}
+{"abstract_id": "26437529", "label": "results", "text": "Three hundred seventeen pregnant women were recruited into the present study , @ in the menthol group and @ in the non-menthol group .", "sentence_id": 4}
+{"abstract_id": "26437529", "label": "results", "text": "Mean VAS score of the post-procedure pain and anxiety did not differ significantly between the two groups .", "sentence_id": 5}
+{"abstract_id": "26437529", "label": "results", "text": "Mean VAS score of the anticipated pain influenced the mean VAS score of the pre-procedure anxiety and post-procedure pain and anxiety irrespective of the group .", "sentence_id": 6}
+{"abstract_id": "26437529", "label": "results", "text": "Mean VAS score of the pre-procedure anxiety and post-procedure pain and anxiety increased about @ cm for each @ cm of increasing mean VAS score of anticipated pain .", "sentence_id": 7}
+{"abstract_id": "26437529", "label": "conclusions", "text": "Aromatic therapy using menthol was not significantly effective in reducing pain and anxiety during second trimester genetic amniocentesis .", "sentence_id": 8}
+{"abstract_id": "26040181", "label": "objective", "text": "Immune response and consequent inflammatory process which originate on ocular surface after a trauma are mediated by cytokines .", "sentence_id": 0}
+{"abstract_id": "26040181", "label": "objective", "text": "Photoablation of corneal stroma performed by excimer laser causes surgically induced trauma .", "sentence_id": 1}
+{"abstract_id": "26040181", "label": "objective", "text": "Interleukin-@ ( IL-@ ) is mostly known as a proinflammatory cytokine .", "sentence_id": 2}
+{"abstract_id": "26040181", "label": "objective", "text": "However , it also has regenerative and anti-inflammatory effects .", "sentence_id": 3}
+{"abstract_id": "26040181", "label": "objective", "text": "It is supposed that this cytokine is likely to play a significant role in the process of corneal wound healing response after photoablation of stroma carried out by laser in situ keratomileusis ( LASIK ) or photorefractive keratectomy ( PRK ) methods .", "sentence_id": 4}
+{"abstract_id": "26040181", "label": "objective", "text": "The aim of this study was to determine and compare the levels of IL-@ in tears before and after treatment with LASIK and PRK methods .", "sentence_id": 5}
+{"abstract_id": "26040181", "label": "methods", "text": "The study included @ shortsighted eyes up to -@ diopter sphere , i.e. @ samples of tears ( per three samples taken from each of the eyes ) , divided into two groups according to the kind of excimer laser intervention performed : the group @ -- eyes treated by LASIK method ( n = @ ) , and the group @ -- eyes treated by the PRK method ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "26040181", "label": "methods", "text": "The samples of tears were taken from each eye at the following time points : before excimer laser treatment ( @ h , the control group ) , @ h after the treatment ( @ h ) and @ h after the treatment ( @ h ) .", "sentence_id": 7}
+{"abstract_id": "26040181", "label": "methods", "text": "The patients did not use anti-inflammatory therapy @ h after the intervention .", "sentence_id": 8}
+{"abstract_id": "26040181", "label": "methods", "text": "Tear samples were collected using microsurgical sponge .", "sentence_id": 9}
+{"abstract_id": "26040181", "label": "methods", "text": "Level of IL-@ in tear fluid was determined by the flow cytometry method , applying a commercial test kit which allowed cytokine detection from a small sample volume .", "sentence_id": 10}
+{"abstract_id": "26040181", "label": "methods", "text": "Results .", "sentence_id": 11}
+{"abstract_id": "26040181", "label": "methods", "text": "The values of IL-@ were detectable in @ % of samples before LASIK treatment and in @ % of samples before PRK treatment .", "sentence_id": 12}
+{"abstract_id": "26040181", "label": "methods", "text": "One h after the treatment IL-@ was detectable in @ % of samples for the LASIK group and @ % of samples for the PRK group , and @ h after the treatment it was detectable in @ % of samples for the LASIK group and in @ % of samples for the PRK group .", "sentence_id": 13}
+{"abstract_id": "26040181", "label": "methods", "text": "When we analyzed the dynamics of IL@ production in particular groups , we noticed that both in the LASIK and PRK group the number of samples with increased values of IL-@ after @ h , and after @ h , was con - siderably larger than the number of samples with decreased values of IL-@ after the intervention .", "sentence_id": 14}
+{"abstract_id": "26040181", "label": "methods", "text": "Analyzing the dynamics of IL-@ concentration changes in the @ h samples vs. @ h samples there was a statistically significant increase in the number of samples with IL-@ concentration decline in the LASIK group , while at the same time no considerable changes occurred in the PRK group .", "sentence_id": 15}
+{"abstract_id": "26040181", "label": "methods", "text": "Comparing average IL-@ values between the two treatment groups in all tear samples at @ h , @ h and @ h after intervention a significantly higher level in the PRK group @ h after procedure ( p = @ ) was detected .", "sentence_id": 16}
+{"abstract_id": "26040181", "label": "conclusions", "text": "IL-@ level in tears increases @ h and @ h after LASIK and PRK treatments .", "sentence_id": 17}
+{"abstract_id": "26040181", "label": "conclusions", "text": "This increment is significantly larger @ h after the treatment with the PRK method than with the LASIK method .", "sentence_id": 18}
+{"abstract_id": "26040181", "label": "conclusions", "text": "Changes of IL-@ production levels in tears after excimer laser treatment indicate that this cytokine takes part in the corneal recovery process after stromal photoablation .", "sentence_id": 19}
+{"abstract_id": "25187436", "label": "background", "text": "Although half of all patients with heart failure ( HF ) have a normal or near-normal ejection fraction and their prognosis differs little from that of patients with a reduced ejection fraction , the pathophysiology of HF with preserved ejection fraction ( HF-PEF ) is still poorly understood , and its management poorly supported by clinical trials .", "sentence_id": 0}
+{"abstract_id": "25187436", "label": "background", "text": "Sodium and fluid restriction is the most common self-care measure prescribed to HF patients for management of congestive episodes .", "sentence_id": 1}
+{"abstract_id": "25187436", "label": "background", "text": "However , its role in the treatment of HF-PEF remains unclear .", "sentence_id": 2}
+{"abstract_id": "25187436", "label": "background", "text": "This trial seeks to compare the effects of a sodium - and fluid-restricted diet versus an unrestricted diet on weight loss , neurohormonal activation , and clinical stability in patients admitted for decompensated HF-PEF .", "sentence_id": 3}
+{"abstract_id": "25187436", "label": "methods", "text": "This is a randomized , parallel trial with blinded outcome assessment .", "sentence_id": 4}
+{"abstract_id": "25187436", "label": "methods", "text": "The sample will include adult patients ( aged @years ) with a diagnosis of HF-PEF admitted for HF decompensation .", "sentence_id": 5}
+{"abstract_id": "25187436", "label": "methods", "text": "The patients will be randomized to receive a diet with sodium and fluid intake restricted to @ g/day and @mL/day respectively ( intervention group ) or an unrestricted diet , with @g/day sodium and unlimited fluid intake ( control group ) , and followed for @days or until hospital discharge .", "sentence_id": 6}
+{"abstract_id": "25187436", "label": "methods", "text": "The primary outcome shall consist of weight loss at @days or discharge .", "sentence_id": 7}
+{"abstract_id": "25187436", "label": "methods", "text": "The secondary outcome includes assessment of clinical stability , neurohormonal activation , daily perception of thirst and readmission rate at @days .", "sentence_id": 8}
+{"abstract_id": "25187436", "label": "conclusions", "text": "Assessment of the effects of sodium and fluid restriction on neurohormonal activation and clinical course of HF-PEF can promote a deeper understanding of the pathophysiology and progression of this complex syndrome .", "sentence_id": 9}
+{"abstract_id": "24913488", "label": "background", "text": "New in-vehicle technologies often outpace the scientific support for their value .", "sentence_id": 0}
+{"abstract_id": "24913488", "label": "background", "text": "In lieu of valid and consistent scientific support , common wisdom is used , as in the assumption that enhanced roadway delineation improves driving safety .", "sentence_id": 1}
+{"abstract_id": "24913488", "label": "objective", "text": "To evaluate the effects of a Visibility Enhancement System that selectively improves lane markers ' visibility on driving safety .", "sentence_id": 2}
+{"abstract_id": "24913488", "label": "methods", "text": "A simulation experiment assessed the effects of an in-car lane Visibility Enhancement System ( VES ) that highlights the edges of the road ahead on driver 's behavior and overall safety , under normal and reduced visibility conditions .", "sentence_id": 3}
+{"abstract_id": "24913488", "label": "methods", "text": "Thirty drivers drove in a fix-based simulator through a winding rural road , while attempting to avoid un-enhanced and unexpected obstacles that appeared on the driving lane from time to time .", "sentence_id": 4}
+{"abstract_id": "24913488", "label": "methods", "text": "The simulated VES highlighted the road edges up to a distance of @ m with two alternative configurations : two continuous red lines or a series of red crosses .", "sentence_id": 5}
+{"abstract_id": "24913488", "label": "methods", "text": "The effects of the two VES configurations on performance were measured during night and fog driving .", "sentence_id": 6}
+{"abstract_id": "24913488", "label": "methods", "text": "Performance measures included speed , lane keeping behavior , eye scanning pattern , reaction time ( RT ) and collisions with the un-enhanced unexpected obstacles .", "sentence_id": 7}
+{"abstract_id": "24913488", "label": "methods", "text": "Subjective measures included confidence and stress .", "sentence_id": 8}
+{"abstract_id": "24913488", "label": "results", "text": "With the VES , drivers were more confident , less stressed , and drove faster , but had almost twice as many collisions with the unexpected obstacles .", "sentence_id": 9}
+{"abstract_id": "24913488", "label": "results", "text": "Also , steering/braking RT to the obstacles was longer with the VES than without it by nearly @ msec .", "sentence_id": 10}
+{"abstract_id": "24913488", "label": "conclusions", "text": "The results are consistent with Lebowitz 's theory ( @ ) .", "sentence_id": 11}
+{"abstract_id": "24913488", "label": "conclusions", "text": "While the VES enhanced spatial orientation , it fooled the drivers into assuming that the visibility of obstacles on the road was also improved , and thus actually reduced safety .", "sentence_id": 12}
+{"abstract_id": "24913488", "label": "conclusions", "text": "When visibility is an issue in nighttime crashes , the site-specific crashes should be investigated , in cases of collision with objects-on-the-road , improved delineation should be ruled out .", "sentence_id": 13}
+{"abstract_id": "26170351", "label": "background", "text": "Pregabalin may reduce postoperative pain and opioid use .", "sentence_id": 0}
+{"abstract_id": "26170351", "label": "background", "text": "Higher doses may be more effective , but may cause sedation and confusion .", "sentence_id": 1}
+{"abstract_id": "26170351", "label": "background", "text": "This prospective , randomized , blinded , placebo-controlled study tested the hypothesis that pregabalin reduces pain at @ weeks after total knee arthroplasty , but increases drowsiness and confusion .", "sentence_id": 2}
+{"abstract_id": "26170351", "label": "methods", "text": "Patients ( @ per group ) received capsules containing pregabalin ( @ , @ , @ , or @ mg ) ; two capsules before surgery , one capsule twice a day until postoperative day ( POD ) @ , one on POD@ , and one on POD@ .", "sentence_id": 3}
+{"abstract_id": "26170351", "label": "methods", "text": "Multimodal analgesia included femoral nerve block , epidural analgesia , oxycodone-paracetamol , and meloxicam .", "sentence_id": 4}
+{"abstract_id": "26170351", "label": "methods", "text": "The primary outcome was pain with flexion ( POD@ ) .", "sentence_id": 5}
+{"abstract_id": "26170351", "label": "results", "text": "Pregabalin did not reduce pain at rest , with ambulation , or with flexion at @ weeks ( P = @ , @ , and @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "26170351", "label": "results", "text": "Pregabalin increased POD@ drowsiness ( @ , @ , @ , and @ % in the @ , @ , @ , and @ mg arms , respectively ; P = @ ) , but did not increase confusion ( @ , @ , @ , and @ % , respectively ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26170351", "label": "results", "text": "Pregabalin had no effect on acute or chronic pain , opioid consumption , or analgesic side-effects .", "sentence_id": 8}
+{"abstract_id": "26170351", "label": "results", "text": "Pregabalin reduced POD@ patient satisfaction -LSB- @-@ scale , median ( first quartile , third quartile ) : @ ( @ , @ ) , @ ( @ , @ ) , @ ( @ , @ ) , and @ ( @ , @ ) , respectively ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26170351", "label": "results", "text": "Protocol compliance was @ % by POD@ ( @ , @ , @ , and @ % compliance , respectively ) , with no effect of dose on compliance .", "sentence_id": 10}
+{"abstract_id": "26170351", "label": "results", "text": "Per-protocol analysis of compliant patients showed no effect of pregabalin on pain scores .", "sentence_id": 11}
+{"abstract_id": "26170351", "label": "conclusions", "text": "Pregabalin had no beneficial effects , but increased sedation and decreased patient satisfaction .", "sentence_id": 12}
+{"abstract_id": "26170351", "label": "conclusions", "text": "This study does not support routine perioperative pregabalin for total knee arthroplasty patients .", "sentence_id": 13}
+{"abstract_id": "24382030", "label": "background", "text": "Obstructive sleep apnea ( OSA ) and hypertension are well-known cardiovascular risk factors .", "sentence_id": 0}
+{"abstract_id": "24382030", "label": "background", "text": "Their control could reduce the burden of heart disease across populations .", "sentence_id": 1}
+{"abstract_id": "24382030", "label": "background", "text": "Several drugs are used to control hypertension , but the only consistently effective treatment of OSA is continuous positive airway pressure .", "sentence_id": 2}
+{"abstract_id": "24382030", "label": "background", "text": "The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases .", "sentence_id": 3}
+{"abstract_id": "24382030", "label": "methods", "text": "This is a randomized double-blind clinical trial , comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than @ years of age with stage I hypertension ( @ to @/@ to @mmHg ) and moderate OSA ( @ to @ apneas/hour of sleep ) .", "sentence_id": 4}
+{"abstract_id": "24382030", "label": "methods", "text": "The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring .", "sentence_id": 5}
+{"abstract_id": "24382030", "label": "methods", "text": "The secondary outcomes are adverse events , somnolence scale ( Epworth ) , ventilatory parameters and C reactive protein levels .", "sentence_id": 6}
+{"abstract_id": "24382030", "label": "methods", "text": "The follow-up will last @ weeks .", "sentence_id": 7}
+{"abstract_id": "24382030", "label": "methods", "text": "There will be @ participants per group .", "sentence_id": 8}
+{"abstract_id": "24382030", "label": "methods", "text": "The project has been approved by the ethics committee of our institution .", "sentence_id": 9}
+{"abstract_id": "24382030", "label": "conclusions", "text": "The role of fluid retention in OSA has been known for several decades .", "sentence_id": 10}
+{"abstract_id": "24382030", "label": "conclusions", "text": "The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea .", "sentence_id": 11}
+{"abstract_id": "24382030", "label": "conclusions", "text": "As well as testing the efficacy of these drugs , this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment .", "sentence_id": 12}
+{"abstract_id": "25319951", "label": "objective", "text": "The beneficial effect of rosuvastatin against percutaneous coronary intervention ( PCI ) related procedural myocardial injury has been determined mostly in patients with acute coronary syndromes ( ACS ) .", "sentence_id": 0}
+{"abstract_id": "25319951", "label": "objective", "text": "However , the detailed therapeutic mechanism has not been well studied .", "sentence_id": 1}
+{"abstract_id": "25319951", "label": "methods", "text": "Patients with ACS receiving PCI ( n = @ ) were randomized to control group ( placebo treatment ) or to rosuvastatin group ( @ mg @ h before PCI , and a further @ mg @ h preprocedure dose ) .", "sentence_id": 2}
+{"abstract_id": "25319951", "label": "methods", "text": "Levels of INF - , TNF - , IL-@ , miR-@ / SHIP-@ , and CD@ ( + ) FoxP@ ( + ) Treg in peripheral blood were detected before PCI and @ h after PCI .", "sentence_id": 3}
+{"abstract_id": "25319951", "label": "methods", "text": "Clinical data of these patients were also collected in this prospective study .", "sentence_id": 4}
+{"abstract_id": "25319951", "label": "results", "text": "Compared with placebo , rosuvastatin treatment significantly reduced the incidence of periprocedural myocardial infarction ( PMI ) and levels of cardiac troponin I ( cTnI ) associated with decreased relative expression of serum miR-@ , levels of inflammatory cytokines ( INF - , TNF - , and IL-@ ) , increased SHIP-@ expression and CD@ ( + ) FoxP@ ( + ) Treg percentage values ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25319951", "label": "results", "text": "In addition , patients with rosuvastatin pretreatment also reduced incidence of @ days major adverse cardiac events ( MACE ) compared to the patients with placebo treatment ( @ patients vs. @ patients , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25319951", "label": "conclusions", "text": "Our study suggests that high loading dose rosuvastatin pretreatment may reduce the incidence of cardiovascular events and levels of inflammatory markers in patients with ACS receiving PCI , which may be explained at least in part , by mechanism involving suppression of miR-@ / SHIP-@ signaling pathway .", "sentence_id": 7}
+{"abstract_id": "25469829", "label": "objective", "text": "Adherence to insulin therapy can be threatened by pain and needle fear .", "sentence_id": 0}
+{"abstract_id": "25469829", "label": "objective", "text": "This cross-over randomized non-inferiority trial evaluated a new Pic Insupen @G@mm needle vs. a @G@mm needle in terms of metabolic control , safety and acceptability in patients with diabetes treated with insulin .", "sentence_id": 1}
+{"abstract_id": "25469829", "label": "methods", "text": "We used a centralized , permuted block randomization , stratified by center and maximum insulin dose per single injection .", "sentence_id": 2}
+{"abstract_id": "25469829", "label": "methods", "text": "Subjects used the two needles in two @ week treatment periods .", "sentence_id": 3}
+{"abstract_id": "25469829", "label": "methods", "text": "The primary endpoint was the absolute percentage variation of the blood fructosamine between the two treatments ( % | Fru | ) .", "sentence_id": 4}
+{"abstract_id": "25469829", "label": "methods", "text": "Additional endpoints were : glycemic variability , total insulin doses , body weight , severe hypoglycemic episodes , leakage at injection sites and pain measured by visual analogue scale .", "sentence_id": 5}
+{"abstract_id": "25469829", "label": "methods", "text": "Equivalent glycemic control was defined a priori as % | Fru | ( including @ % CI ) within @ % .", "sentence_id": 6}
+{"abstract_id": "25469829", "label": "results", "text": "Of @ subjects randomized , @ completed the study ( median age @ -LSB- IR @-@ @ -RSB- , median BMI @ Kg/m ( @ ) -LSB- IR @-@ @ -RSB- , median duration of insulin therapy -LSB- in months -RSB- @ ( IR @-@ @ ) , median baseline HbA@c @ % -LSB- IR @-@ @ -RSB- ) .", "sentence_id": 7}
+{"abstract_id": "25469829", "label": "results", "text": "The % | Fru | was @ % ( @ % CI @-@ @ ) , meeting the non-inferiority criterion .", "sentence_id": 8}
+{"abstract_id": "25469829", "label": "results", "text": "The fasting blood glucose standard deviation was @ ( mean @ ) with the @G needle and @ ( mean @ ) with the @G needle ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25469829", "label": "results", "text": "Insulin daily dose and patients ' weight did not show any statistically significant variation .", "sentence_id": 10}
+{"abstract_id": "25469829", "label": "results", "text": "We observed @ episodes of symptomatic hypoglycemia with the @G needle and @ with the @G needle .", "sentence_id": 11}
+{"abstract_id": "25469829", "label": "results", "text": "One episode of severe hypoglycemia was documented in the latter group .", "sentence_id": 12}
+{"abstract_id": "25469829", "label": "results", "text": "As for insulin leakage we observed @ episodes per @ patient-days with the @G needle and @ episodes per @ patient-days with the @G needle ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25469829", "label": "results", "text": "Patients reported less pain with the @G@mm needle ( p = @ ) .", "sentence_id": 14}
+{"abstract_id": "25469829", "label": "conclusions", "text": "Study sample was mainly composed of adults with type @ diabetes and study was not blinded .", "sentence_id": 15}
+{"abstract_id": "25469829", "label": "conclusions", "text": "The @G needle is not inferior to the @G needle in terms of efficacy and safety , with reduced pain and no difference in insulin leakage .", "sentence_id": 16}
+{"abstract_id": "24824050", "label": "background", "text": "Pregnancy and the postpartum period present important intervention opportunities .", "sentence_id": 0}
+{"abstract_id": "24824050", "label": "background", "text": "Counseling can leverage the motivation women have during this time to change behaviors that may negatively affect their health and the heath of their infants .", "sentence_id": 1}
+{"abstract_id": "24824050", "label": "methods", "text": "Pregnant women attending an antenatal clinic in South Africa were randomly allocated to treatment ( n = @ ) and control arms ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24824050", "label": "methods", "text": "Treatment arm participants received enhanced HIV pre - and post-test counseling , legal support and access to support groups at baseline , which occurred at the first antenatal visit , and then six and ten weeks postpartum .", "sentence_id": 3}
+{"abstract_id": "24824050", "label": "methods", "text": "Control arm participants received standard HIV testing and counseling ( HTC ) and two postpartum attention control sessions .", "sentence_id": 4}
+{"abstract_id": "24824050", "label": "methods", "text": "Outcomes were incidence of sexually transmitted infection ( STI ) by @ weeks postpartum and past @-day inconsistent condom use at @ weeks and @ months postpartum .", "sentence_id": 5}
+{"abstract_id": "24824050", "label": "results", "text": "There were no intervention effects on incident STIs for either HIV-negative ( adjusted risk ratio ( aRR ) @ , @ % CI @-@ @ ) or HIV-positive participants ( aRR @ , @ % CI @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24824050", "label": "results", "text": "The intervention was associated with a @ % decrease in risk of past @-day inconsistent condom use at nine-months among HIV-negative women ( aRR @,@ % CI @-@ @ ) , but did not affect inconsistent condom use among HIV-positive women ( aRR@ @ ; @ % CI @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24824050", "label": "conclusions", "text": "An enhanced counseling intervention during pregnancy and the postpartum period can lead to reductions in inconsistent condom use among HIV-negative women .", "sentence_id": 8}
+{"abstract_id": "24824050", "label": "conclusions", "text": "Results underscore the importance of the counseling that accompanies HIV HTC .", "sentence_id": 9}
+{"abstract_id": "24824050", "label": "conclusions", "text": "More work is needed to understand how to promote and sustain risk reduction among HIV-positive women .", "sentence_id": 10}
+{"abstract_id": "24602923", "label": "objective", "text": "Simeprevir is an oral , once-daily inhibitor of hepatitis c virus ( HCV ) protease NS@/@A .", "sentence_id": 0}
+{"abstract_id": "24602923", "label": "objective", "text": "We investigated the safety and efficacy of simeprevir with peg-interferon -@ a and ribavirin ( PR ) in a randomized , double-blind , placebo-controlled , phase @ trial of patients with HCV genotype @ infection who relapsed after previous interferon-based therapy .", "sentence_id": 1}
+{"abstract_id": "24602923", "label": "methods", "text": "Patients were assigned randomly ( @:@ ) to groups given simeprevir ( @ mg , once daily ) and PR ( n = @ ) or placebo and PR ( n = @ ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24602923", "label": "methods", "text": "Patients then were given PR alone for @ or @ weeks ( simeprevir group , based on response-guided therapy criteria ) or @ weeks ( placebo group ) .", "sentence_id": 3}
+{"abstract_id": "24602923", "label": "results", "text": "Simeprevir and PR was significantly superior to placebo and PR ; rates of sustained virologic response @ weeks after planned end of treatment ( SVR@ ) were @ % vs @ % , respectively ( @ % difference ; @ % confidence interval , @-@ @ ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24602923", "label": "results", "text": "Among patients given simeprevir , @ % met the response-guided therapy criteria and were eligible to complete PR at week @ ; of these , @ % achieved SVR@ .", "sentence_id": 5}
+{"abstract_id": "24602923", "label": "results", "text": "HCV RNA was undetectable at week @ in @ % of patients given simeprevir and @ % given placebo .", "sentence_id": 6}
+{"abstract_id": "24602923", "label": "results", "text": "On-treatment failure and relapse rates were lower among patients given simeprevir and PR than those given placebo and PR ( @ % vs @ % , and @ % vs @ % , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24602923", "label": "results", "text": "Patients given simeprevir did not have adverse events beyond those that occurred in patients given PR alone .", "sentence_id": 8}
+{"abstract_id": "24602923", "label": "results", "text": "Most adverse events were grades @/@ ; the prevalence of anemia and rash was similar in both groups .", "sentence_id": 9}
+{"abstract_id": "24602923", "label": "results", "text": "Patients in both groups reported similar severity of fatigue and functional impairments during the study , but duration was reduced among patients given simeprevir .", "sentence_id": 10}
+{"abstract_id": "24602923", "label": "conclusions", "text": "In a phase @ trial of patients who had relapsed after interferon-based therapy , the addition of simeprevir to PR was generally well tolerated , with an SVR@ rate of @ % .", "sentence_id": 11}
+{"abstract_id": "24602923", "label": "conclusions", "text": "Most patients ( @ % ) receiving simeprevir were able to shorten therapy to @ weeks .", "sentence_id": 12}
+{"abstract_id": "24602923", "label": "conclusions", "text": "ClinicalTrials.gov number : NCT@ .", "sentence_id": 13}
+{"abstract_id": "24641841", "label": "background", "text": "Due to physical characteristics , ions like protons or carbon ions can administer the dose to the target volume more efficiently than photons since the dose can be lowered at the surrounding normal tissue .", "sentence_id": 0}
+{"abstract_id": "24641841", "label": "background", "text": "Radiation biological considerations are based on the assumption that the / value for prostate cancer cells is @ Gy , so that a biologically more effective dose could be administered due to hypofractionation without increasing risks of late effects of bladder ( / = @ ) and rectum ( / = @ ) .", "sentence_id": 1}
+{"abstract_id": "24641841", "label": "methods", "text": "The IPI study is a prospective randomized phase II study exploring the safety and feasibility of primary hypofractionated irradiation of the prostate with protons and carbon ions in a raster scan technique .", "sentence_id": 2}
+{"abstract_id": "24641841", "label": "methods", "text": "The study is designed to enroll @ patients with localized prostate cancer .", "sentence_id": 3}
+{"abstract_id": "24641841", "label": "methods", "text": "Primary aim is the assessment of the safety and feasibility of the study treatment on the basis of incidence grade III and IV NCI-CTC-AE ( v. @ ) toxicity and/or the dropout of the patient from the planned therapy due to any reason .", "sentence_id": 4}
+{"abstract_id": "24641841", "label": "methods", "text": "Secondary endpoints are PSA-progression free survival ( PSA-PFS ) , overall survival ( OS ) and quality-of-life ( QoL ) .", "sentence_id": 5}
+{"abstract_id": "24641841", "label": "conclusions", "text": "This pilot study aims at the evaluation of the safety and feasibility of hypofractionated irradiation of the prostate with protons and carbon ions in prostate cancer patients in an active beam technique .", "sentence_id": 6}
+{"abstract_id": "24641841", "label": "conclusions", "text": "Additionally , the safety results will be compared with Japanese results recently published for carbon ion irradiation .", "sentence_id": 7}
+{"abstract_id": "24641841", "label": "conclusions", "text": "Due to the missing data of protons in this hypofractionated scheme , an in depth evaluation of the toxicity will be created to gain basic data for a following comparison study with carbon ion irradiation .", "sentence_id": 8}
+{"abstract_id": "24385269", "label": "objective", "text": "High rates of ischemic stroke and poor adherence to secondary prevention measures are observed in the Chinese population .", "sentence_id": 0}
+{"abstract_id": "24385269", "label": "methods", "text": "We used a national , multicenter , cluster-randomized controlled trial in which @ hospitals were randomized to either a structured care program group ( n = @ ) or a usual care group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24385269", "label": "methods", "text": "The structured care program consisted of a specialist-administered , guideline-recommended pharmaceutical treatment and a lifestyle modification algorithm associated with written and Internet-accessed educational material for patients for the secondary prevention of ischemic stroke .", "sentence_id": 2}
+{"abstract_id": "24385269", "label": "methods", "text": "The primary efficacy outcome was the proportion of patients who adhered to the recommended measures at @-month postdischarge .", "sentence_id": 3}
+{"abstract_id": "24385269", "label": "methods", "text": "This trial is registered with ClinicalTrial.gov ( NCT@ ) .", "sentence_id": 4}
+{"abstract_id": "24385269", "label": "results", "text": "At @ months , @ ( @ % ) patients in the Standard Medical Management in Secondary Prevention of Ischemic Stroke in China ( SMART ) group and @ ( @ % ) patients in the usual care group had completed the @-month follow-up ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24385269", "label": "results", "text": "Compared with the usual care group , those in the SMART group showed higher adherence to statins ( @ % versus @ % ; P = @ ) but no difference in adherence to antiplatelet ( @ % versus @ % ; P = @ ) , antihypertensive ( @ % versus @ % ; P = @ ) , or diabetes mellitus drugs ( @ % versus @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24385269", "label": "results", "text": "No significant difference in the composite end point ( new-onset ischemic stroke , hemorrhagic stroke , acute coronary syndrome , and all-cause death ) was observed ( @ % versus @ % ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24385269", "label": "conclusions", "text": "The implementation of a program to improve adherence to secondary ischemic stroke prevention efforts in China is feasible , but these programs had only a limited impact on adherence and no impact on @-year outcomes .", "sentence_id": 8}
+{"abstract_id": "24385269", "label": "conclusions", "text": "Further development of a structured program to reduce vascular events after stroke is needed .", "sentence_id": 9}
+{"abstract_id": "24385269", "label": "conclusions", "text": "Clinical Trial Registration-URL : http://www.clinicaltrials.gov .", "sentence_id": 10}
+{"abstract_id": "24385269", "label": "conclusions", "text": "Unique identifier : NCT@ .", "sentence_id": 11}
+{"abstract_id": "24873162", "label": "objective", "text": "To compare the effect of transumbilical single-site single-port with that of transumbilical single-site double-port laparoscopic varicocelectomy in the treatment of varicocele in adolescents .", "sentence_id": 0}
+{"abstract_id": "24873162", "label": "methods", "text": "We randomly assigned @ varicocele patients aged @ - @ years to two groups of equal number to receive transumbilical single-site single-port and single-site double-port laparoscopic varicocelectomy , respectively .", "sentence_id": 1}
+{"abstract_id": "24873162", "label": "methods", "text": "We compared the operation time , postoperative hospital stay , incisional pain , complications and satisfaction with the abdominal cosmetic outcomes between the two groups .", "sentence_id": 2}
+{"abstract_id": "24873162", "label": "results", "text": "All the operations were successfully performed .", "sentence_id": 3}
+{"abstract_id": "24873162", "label": "results", "text": "The double-port group showed a significantly higher score on the Visual Analogue Scale than the single-port group ( @ + / - @ vs @ + / - @ , t = -@ , P < @ ) , but there were no significant differences between the two groups in the operation time ( -LSB- @ + / - @ -RSB- vs -LSB- @ + / - @ -RSB- min , t = @ , P = @ ) , postoperative hospital stay ( -LSB- @ + / - @ -RSB- vs -LSB- @ + / - @ -RSB- d , t = -@ , P = @ ) , complications ( @ vs @ ) and scores on the satisfaction with abdominal cosmetic outcomes ( @ + / - @ vs @ + / - @ , t = @ , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24873162", "label": "results", "text": "No recurrence , umbilical hernia , hydrocele and orchiatrophy were found in the two groups of patients at @ months after operation , and no visible scar was observed on the abdominal surface .", "sentence_id": 5}
+{"abstract_id": "24873162", "label": "conclusions", "text": "With strict surgical indications , single-site single-port and single-site double-port laparoscopic varicocelectomies have similar clinical effects in the treatment of varicocele , which leave no scar on the abdominal surface .", "sentence_id": 6}
+{"abstract_id": "24873162", "label": "conclusions", "text": "Single-site double-port laparoscopy needs no special instruments and therefore is worthier of wide clinical application .", "sentence_id": 7}
+{"abstract_id": "25099167", "label": "background", "text": "Clinical decision rules ( CDRs ) can be an effective tool for knowledge translation in emergency medicine , but their implementation is often a challenge .", "sentence_id": 0}
+{"abstract_id": "25099167", "label": "background", "text": "This study examined whether the Theory of Planned Behaviour ( TPB ) could help explain the inconsistent results between the successful Canadian C-Spine Rule ( CCR ) implementation study and unsuccessful Canadian CT Head Rule ( CCHR ) implementation study .", "sentence_id": 1}
+{"abstract_id": "25099167", "label": "background", "text": "Both rules are aimed at improving the accuracy and efficiency of emergency department radiography use in clinical contexts that exhibit enormous inefficiency at the present time .", "sentence_id": 2}
+{"abstract_id": "25099167", "label": "background", "text": "The rules were prospectively derived and validated using the same methodology demonstrating high sensitivity and reliability .", "sentence_id": 3}
+{"abstract_id": "25099167", "label": "background", "text": "The rules subsequently underwent parallel implementations at @ Canadian hospitals , yet only the CCR was observed to significantly reduce radiography ordering rates , while the CCHR failed to have any significant impact at all .", "sentence_id": 4}
+{"abstract_id": "25099167", "label": "background", "text": "The drastically different results are unlikely to be the result of differences in implementation strategies or the decision rules .", "sentence_id": 5}
+{"abstract_id": "25099167", "label": "methods", "text": "Physicians at the @ participating Canadian hospitals were randomized to CCR or CCHR TPB surveys that were administered during the baseline phases of the implementation studies , before any intervention had taken place .", "sentence_id": 6}
+{"abstract_id": "25099167", "label": "methods", "text": "The collected baseline survey data were linked to concurrent baseline physician and patient-specific imaging data , and subsequently analyzed using mixed effects linear and logistic models .", "sentence_id": 7}
+{"abstract_id": "25099167", "label": "results", "text": "A total of @ of the @ eligible physicians randomized to a TPB survey completed their assigned baseline survey ( CCR : @ of @ ; CCHR : @ of @ ) .", "sentence_id": 8}
+{"abstract_id": "25099167", "label": "results", "text": "Attitudes were significantly associated with intention in both settings ( CCR : = @ ; CCHR : = @ ) , as were subjective norms ( CCR : = @ ; CCHR : = @ ) .", "sentence_id": 9}
+{"abstract_id": "25099167", "label": "results", "text": "Intention was significantly associated with actual image ordering for CCR ( OR = @ ) , but not CCHR .", "sentence_id": 10}
+{"abstract_id": "25099167", "label": "conclusions", "text": "The TPB can be used to better understand processes underlying use of CDRs .", "sentence_id": 11}
+{"abstract_id": "25099167", "label": "conclusions", "text": "TPB constructs were significantly associated with intention to perform both imaging behaviours , but intention was only associated with actual behaviour for CCR , suggesting that constructs outside of the TPB framework may need to be considered when seeking to understand use of CDRs .", "sentence_id": 12}
+{"abstract_id": "25233649", "label": "objective", "text": "To compare the efficacy difference of analgesia and detumescence on ankle sprain among acupuncture at Xiaojie point combined with tendon regulation manipulation , acupuncture at Xiaojie point and tendon regulation manipulation .", "sentence_id": 0}
+{"abstract_id": "25233649", "label": "methods", "text": "Sixty cases of ankle sprain were randomized into a combined therapy group , a Xiaojie point group and a tendon-regulation manipulation group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25233649", "label": "methods", "text": "The combined therapy of acupuncture at Xiaojie point and tendon regulation manipulation , the acupuncture at Xiaojie point and the simple application of tendon-regulation manipulation were applied respectively in the three groups , once a day , @ treatments were required .", "sentence_id": 2}
+{"abstract_id": "25233649", "label": "methods", "text": "The symptom score such as pain , ecchymosis , swelling and motor dysfunction and the total score were observed before and after treatment in the three groups .", "sentence_id": 3}
+{"abstract_id": "25233649", "label": "methods", "text": "The different values of pain and swelling scores were compared before and after treatment in the three groups .", "sentence_id": 4}
+{"abstract_id": "25233649", "label": "methods", "text": "The efficacy was compared among the groups .", "sentence_id": 5}
+{"abstract_id": "25233649", "label": "results", "text": "The total effective rate was @ % ( @/@ ) in each group .", "sentence_id": 6}
+{"abstract_id": "25233649", "label": "results", "text": "But the curative rate was @ % ( @/@ ) in the combined group , @ % ( @/@ ) in the Xiaojie point tion manipulation group .", "sentence_id": 7}
+{"abstract_id": "25233649", "label": "results", "text": "After treatment , the symptom scores of pain , ecchymosis , swelling and motor dysfunction and the total score were all improved as compared with those before treatment in the three groups ( P < @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25233649", "label": "results", "text": "The pain score in either the combined therapy group or Xiaojie point group was lower than that in the tendon-regulation manipulation group after treatment ( @ - / + @ , @ + / - @ vs @ + / - @ , both P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25233649", "label": "results", "text": "Swelling score in the Xiaojie point group was different significantly from that in the tendon-regulation manipulation @ vs @ vs. @ +@ , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25233649", "label": "results", "text": "The different value of pain score in either the combined therapy group or Xiaojie point group was higher than that in the tendon-regulation manipulation group before group after treatment ( @ bined therapy group or Xiaojie point group was higher than that in the tendon-regulation manipulation group before and after treatment ( @ + / - @ , @ + / - @ vs @ + / - @ , both P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25233649", "label": "results", "text": "The different value of swelling score in the tendon-regulation manipulation group was higher than that in the Xiaojie point group before and after treatment ( @ + / - @ vs @ + / - @ , P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25233649", "label": "conclusions", "text": "Acupuncture at Xiaojie point combined with tendon-regulation manipulation achieve an apparent effect of analgesia and detumescence on ankle sprain .", "sentence_id": 13}
+{"abstract_id": "25413071", "label": "objective", "text": "To explore the clinical efficacy and safety of the early use of urokinase in the prevention and treatment on tunneled hemodialysis catheter related fibrin sheaths .", "sentence_id": 0}
+{"abstract_id": "25413071", "label": "methods", "text": "Thirty-eight hemodialysis patients with tunneled central venous catheter and good catheter function were randomly divided into experimental group and control group .", "sentence_id": 1}
+{"abstract_id": "25413071", "label": "methods", "text": "Urokinase was given after @ days of indwelling catheter in the experimental group and after the onset of catheter dysfunction in the control group .", "sentence_id": 2}
+{"abstract_id": "25413071", "label": "methods", "text": "The catheter function , mean blood flow and venous pressure of dialysis , coagulation , and side effects in the two groups were observed for @ months .", "sentence_id": 3}
+{"abstract_id": "25413071", "label": "results", "text": "The rates of catheter dysfunction on the arterial side were @ % and @ % in the experimental group and control group , respectively ( P < @ ) , with catheter dysfunction rates on the vein side of @ % and @ % , respectively ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25413071", "label": "results", "text": "Catheter dysfunction occurred for the first time at @ @ days in the experimental group , and at @ @ days in the control group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25413071", "label": "results", "text": "The mean blood flow showed no significant difference between the two groups at @ month after tube insertion ( P > @ ) , but was higher in the experimental group at @ and @ months after the tube insertion ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25413071", "label": "results", "text": "The mean venous pressure in two groups was similar @ and @ months after tube insertion ( P > @ ) , but was significantly lower in the experimental group at @ months ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25413071", "label": "results", "text": "Compared with control group , the experimental group showed significantly prolonged prothrombin time ( P < @ ) but similar rest coagulation parameters .", "sentence_id": 8}
+{"abstract_id": "25413071", "label": "results", "text": "No serious drug-related side effects occurred in these two groups .", "sentence_id": 9}
+{"abstract_id": "25413071", "label": "conclusions", "text": "Early use of urokinase is safe and effective for prevention and treatment of tunneled hemodialysis catheter-related fibrin sheaths with minimal side effects .", "sentence_id": 10}
+{"abstract_id": "24722047", "label": "background", "text": "Therapeutic ultrasound and transcutaneous electrical nerve stimulation ( TENS ) have been described as being effective in the treatment of spasticity .", "sentence_id": 0}
+{"abstract_id": "24722047", "label": "background", "text": "No previous study compared these physical modalities with a first-line treatment for spasticity , such as botulinum toxin type A.", "sentence_id": 1}
+{"abstract_id": "24722047", "label": "objective", "text": "To compare the effects of therapeutic ultrasound and TENS with botulinum toxin type A on spasticity after stroke .", "sentence_id": 2}
+{"abstract_id": "24722047", "label": "methods", "text": "Thirty patients with chronic stroke and spastic equinus were randomly assigned to @ groups : @ group received therapeutic ultrasound to the affected leg calf muscles , @ group underwent TENS to the tibial nerve of the affected leg , and @ group was injected with onabotulinum toxin A in the spastic gastrocnemius .", "sentence_id": 3}
+{"abstract_id": "24722047", "label": "methods", "text": "All patients were evaluated immediately before treatment and @ , @ , and @ days after the first clinical evaluation .", "sentence_id": 4}
+{"abstract_id": "24722047", "label": "methods", "text": "The following outcome measures were considered : ankle passive dorsiflexion range of motion and the modified Ashworth scale .", "sentence_id": 5}
+{"abstract_id": "24722047", "label": "results", "text": "Patients injected with botulinum toxin type A had significantly better ankle passive range of motion than those treated with physical modalities at all posttreatment evaluations .", "sentence_id": 6}
+{"abstract_id": "24722047", "label": "results", "text": "At second and third posttreatment evaluations , the modified Ashworth scale indicated significantly greater improvement in patients injected with botulinum toxin type A than in those treated with physical modalities .", "sentence_id": 7}
+{"abstract_id": "24722047", "label": "results", "text": "No difference was found between groups treated with physical modalities .", "sentence_id": 8}
+{"abstract_id": "24722047", "label": "conclusions", "text": "Our findings support the hypothesis that botulinum toxin type A is more effective than therapeutic ultrasound and TENS for treating focal spasticity in patients with chronic stroke .", "sentence_id": 9}
+{"abstract_id": "25638326", "label": "background", "text": "GOG @ was a practice-changing randomised phase @ trial that concluded that chemotherapy plus bevacizumab for advanced cervical cancer significantly improves overall and progression-free survival , and the proportion of patients achieving an overall objective response , compared with chemotherapy alone .", "sentence_id": 0}
+{"abstract_id": "25638326", "label": "background", "text": "In this study , we aimed to analyse patient-reported outcomes in GOG @ .", "sentence_id": 1}
+{"abstract_id": "25638326", "label": "methods", "text": "Eligible adult participants ( aged @ years ) had primary stage IVB or recurrent or persistent carcinoma of the cervix with measurable disease and GOG performance status of @-@ .", "sentence_id": 2}
+{"abstract_id": "25638326", "label": "methods", "text": "Participants were randomly assigned by web-based permuted block randomisation ( block size @ ) in a @:@:@:@ ratio to the four treatment groups : cisplatin ( @ mg/m ( @ ) intravenously on day @ or @ of the treatment cycle ) and paclitaxel ( @ mg/m ( @ ) intravenously over @ h or @ mg/m ( @ ) intravenously over @ h on day @ ) , with or without bevacizumab ( @ mg/kg intravenously on day @ or @ ) , or paclitaxel ( @ mg/m ( @ ) over @ h on day @ ) and topotecan ( @ mg/m ( @ ) for @ min on days @-@ ) with or without bevacizumab ( @ mg/kg intravenously on day @ ) .", "sentence_id": 3}
+{"abstract_id": "25638326", "label": "methods", "text": "Treatment assignment was concealed at randomisation ( everyone was masked to treatment assignment , achieved by the use of a computer encrypted numbering system at the National Cancer Institute ) and became open-label when each patient was registered to the trial .", "sentence_id": 4}
+{"abstract_id": "25638326", "label": "methods", "text": "Treatment cycles were repeated every @ days until disease progression or unacceptable toxicity , whichever occurred first .", "sentence_id": 5}
+{"abstract_id": "25638326", "label": "methods", "text": "The coprimary endpoints of the trial were overall survival and safety ; the primary quality-of-life endpoint was the score on the Functional Assessment of Cancer Therapy-Cervix Trial Outcome Index ( FACT-Cx TOI ) .", "sentence_id": 6}
+{"abstract_id": "25638326", "label": "methods", "text": "For our analysis of patient-reported outcomes , participants were assessed before treatment cycles @ , @ , and @ , and at @ and @ months after the start of cycle @ , with the FACT-Cx TOI , items from the FACT-GOG-Neurotoxicity subscale , and a worst pain item from the Brief Pain Inventory .", "sentence_id": 7}
+{"abstract_id": "25638326", "label": "methods", "text": "All patients who completed baseline quality-of-life assessments and at least one further follow-up assessment were evaluable for quality-of-life outcomes .", "sentence_id": 8}
+{"abstract_id": "25638326", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 9}
+{"abstract_id": "25638326", "label": "results", "text": "Between April @ , @ , and Jan @ , @ , a total of @ patients were enrolled in the trial , of whom @ completed baseline quality-of-life assessment and at least one further assessment and were therefore evaluable for quality-of-life outcomes .", "sentence_id": 10}
+{"abstract_id": "25638326", "label": "results", "text": "In these patients , patient-reported outcome completion declined from @ ( @ % ) of @ ( at baseline ) to @ ( @ % ) of @ ( @ months post-cycle @ ) , but completion rates did not differ significantly between treatment regimens ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25638326", "label": "results", "text": "The baseline FACT-Cx TOI scores did not differ significantly between patients who received bevacizumab versus those who did not ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25638326", "label": "results", "text": "Compared with patients who received chemotherapy alone , patients who received chemotherapy plus bevacizumab reported FACT-Cx TOI scores that were an average of @ points lower ( @ % CI -@ to @ ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25638326", "label": "conclusions", "text": "Improvements in overall survival and progression-free survival attributed to the incorporation of bevacizumab into the treatment of advanced cervical cancer were not accompanied by any significant deterioration in health-related quality of life .", "sentence_id": 14}
+{"abstract_id": "25638326", "label": "conclusions", "text": "Patients responding to anti-angiogenesis therapy who maintain an acceptable quality of life could be suitable at progression for treatment with other novel therapies that might confer additional benefit .", "sentence_id": 15}
+{"abstract_id": "24308282", "label": "background", "text": "Multimorbid patients frequently receive complex medication regimens and are at higher risk for adverse drug reactions and hospitalisations .", "sentence_id": 0}
+{"abstract_id": "24308282", "label": "background", "text": "Managing patients with polypharmacy is demanding , because it requires coordination of multiple prescribers and intensive monitoring .", "sentence_id": 1}
+{"abstract_id": "24308282", "label": "background", "text": "Three evidence-based recommendations addressing polypharmacy in primary care are structured medication counselling , use of medication lists and medication reviews to avoid potentially inappropriate medication ( PIM ) .", "sentence_id": 2}
+{"abstract_id": "24308282", "label": "background", "text": "Although promising to improve patient outcomes , these recommendations are not well implemented in German routine care .", "sentence_id": 3}
+{"abstract_id": "24308282", "label": "background", "text": "Implementation of guidelines is often hindered by specific `` determinants of change '' .", "sentence_id": 4}
+{"abstract_id": "24308282", "label": "background", "text": "`` Tailored '' interventions are designed to specifically address previously identified determinants .", "sentence_id": 5}
+{"abstract_id": "24308282", "label": "background", "text": "This study examines a tailored intervention to implement the aforementioned recommendations into German primary care practices .", "sentence_id": 6}
+{"abstract_id": "24308282", "label": "background", "text": "This study is part of the European Tailored Interventions for Chronic Diseases project , which aims at contributing knowledge about the methods used for tailoring .", "sentence_id": 7}
+{"abstract_id": "24308282", "label": "methods", "text": "The study is designed as a cluster randomized controlled trial with primary care practices of general practitioners ( GPs ) who are organized in quality circles .", "sentence_id": 8}
+{"abstract_id": "24308282", "label": "methods", "text": "Quality circles will be the unit of randomization with a @:@ ratio .", "sentence_id": 9}
+{"abstract_id": "24308282", "label": "methods", "text": "Follow-up time is @ months .", "sentence_id": 10}
+{"abstract_id": "24308282", "label": "methods", "text": "GPs and healthcare assistants in the intervention group will receive training on medication management .", "sentence_id": 11}
+{"abstract_id": "24308282", "label": "methods", "text": "Each GP will create a tailored concept of how to implement the three recommendations into his/her practice .", "sentence_id": 12}
+{"abstract_id": "24308282", "label": "methods", "text": "Evidence-based checklists for medication counselling and medication reviews will be provided for physicians .", "sentence_id": 13}
+{"abstract_id": "24308282", "label": "methods", "text": "A tablet PC with an interactive educational tool and information leaflets will be provided for use by patients to inform about the necessity of continuous medication management .", "sentence_id": 14}
+{"abstract_id": "24308282", "label": "methods", "text": "Control practices will not receive special training and will provide care as usual .", "sentence_id": 15}
+{"abstract_id": "24308282", "label": "methods", "text": "Primary outcome is the degree of implementation of the three recommendations , which will be measured using a prespecified set of indicators .", "sentence_id": 16}
+{"abstract_id": "24308282", "label": "methods", "text": "Additionally , the PIM prescription rate , patient activation , patients ' beliefs about medicine , medication adherence and patients ' social support will be measured .", "sentence_id": 17}
+{"abstract_id": "24308282", "label": "conclusions", "text": "This study will contribute knowledge about the feasibility of implementing recommendations for managing patients with polypharmacy in primary care practices .", "sentence_id": 18}
+{"abstract_id": "24308282", "label": "conclusions", "text": "Additionally , this study will contribute knowledge about methods for tailoring of implementation interventions .", "sentence_id": 19}
+{"abstract_id": "25474535", "label": "objective", "text": "This trial evaluated the efficacy of acetaminophen in reducing oxidative injury , as measured by plasma F@-isoprostanes , in adult patients with severe sepsis and detectable plasma cell-free hemoglobin .", "sentence_id": 0}
+{"abstract_id": "25474535", "label": "methods", "text": "Single-center , randomized , double-blind , placebo-controlled phase II trial .", "sentence_id": 1}
+{"abstract_id": "25474535", "label": "methods", "text": "Medical ICU in a tertiary , academic medical center .", "sentence_id": 2}
+{"abstract_id": "25474535", "label": "methods", "text": "Critically ill patients @ years old or older with severe sepsis and detectable plasma cell-free hemoglobin .", "sentence_id": 3}
+{"abstract_id": "25474535", "label": "methods", "text": "Patients were randomized @:@ to enteral acetaminophen @ g every @ hours for @ days ( n = @ ) or placebo ( n = @ ) with the same dosing schedule and duration .", "sentence_id": 4}
+{"abstract_id": "25474535", "label": "results", "text": "F@-Isoprostanes on study day @ , the primary outcome , did not differ between acetaminophen ( @ pg/mL ; interquartile range , @-@ ) and placebo ( @ pg/mL ; interquartile range , @-@ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25474535", "label": "results", "text": "However , F@-isoprostanes were significantly reduced on study day @ in the acetaminophen group ( @ pg/mL ; interquartile range , @-@ ) when compared with placebo ( @ pg/mL ; interquartile range , @-@ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25474535", "label": "results", "text": "Creatinine on study day @ , a secondary outcome , was significantly lower in the acetaminophen group ( @ mg/dL ; interquartile range , @-@ @ ) when compared with that in the placebo ( @ mg/dL ; interquartile range , @-@ @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25474535", "label": "results", "text": "There was no statistically significant difference in hospital mortality ( acetaminophen @ % vs placebo @ % ; p = @ ) or adverse events ( aspartate aminotransferase or alanine aminotransferase > @ ; acetaminophen @ % vs placebo @ % ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25474535", "label": "conclusions", "text": "In adults with severe sepsis and detectable plasma cell-free hemoglobin , treatment with acetaminophen within @ hours of ICU admission may reduce oxidative injury and improve renal function .", "sentence_id": 9}
+{"abstract_id": "25474535", "label": "conclusions", "text": "Additional study is needed to confirm these findings and determine the effect of acetaminophen on patient-centered outcomes .", "sentence_id": 10}
+{"abstract_id": "25458411", "label": "objective", "text": "To explore knowledge and use of female condoms in China , and to compare four modes of failure between the Phoenurse female condom ( PFC ) and the second-generation Femidom female condom ( FC@ ) .", "sentence_id": 0}
+{"abstract_id": "25458411", "label": "methods", "text": "In a randomized , crossover trial , sexually active women aged @-@years who attended a family planning service in Qingdao , China , were recruited between April and October , @ .", "sentence_id": 1}
+{"abstract_id": "25458411", "label": "methods", "text": "A computer-generated randomized sequence was used to assign participants ( @:@ ) to group A ( used @ PFCs followed by @ FC@s ) or group B ( used @ FC@s followed by @ PFCs ) .", "sentence_id": 2}
+{"abstract_id": "25458411", "label": "methods", "text": "Study investigators and participants were masked to allocation .", "sentence_id": 3}
+{"abstract_id": "25458411", "label": "methods", "text": "Participants completed questionnaires at baseline and after using the two types of FCs .", "sentence_id": 4}
+{"abstract_id": "25458411", "label": "methods", "text": "They also kept coital logs .", "sentence_id": 5}
+{"abstract_id": "25458411", "label": "results", "text": "At baseline , @ ( @ % ) of @ participants understood female condoms , but only @ ( @ % ) had ever used one .", "sentence_id": 6}
+{"abstract_id": "25458411", "label": "results", "text": "Total failure rates were @ % ( @/@ @ ) and @ % ( @/@ @ ) for PFC and FC@ , respectively ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25458411", "label": "results", "text": "Slippage was the most common form of failure , affecting @ % of PFC uses and @ % of FC@ uses .", "sentence_id": 8}
+{"abstract_id": "25458411", "label": "results", "text": "Breakage , misdirection , and slippage were significantly more common with the PFC than with the FC@ ( P@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25458411", "label": "conclusions", "text": "Understanding of female condoms is poor in China .", "sentence_id": 10}
+{"abstract_id": "25458411", "label": "conclusions", "text": "Failure is more common with the PFC than with the FC@ .", "sentence_id": 11}
+{"abstract_id": "24888818", "label": "objective", "text": "Increased circulating tumor cells ( CTCs ; five or more CTCs per @ mL of whole blood ) are associated with poor prognosis in metastatic breast cancer ( MBC ) .", "sentence_id": 0}
+{"abstract_id": "24888818", "label": "objective", "text": "A randomized trial of patients with persistent increase in CTCs tested whether changing chemotherapy after one cycle of first-line chemotherapy would improve the primary outcome of overall survival ( OS ) .", "sentence_id": 1}
+{"abstract_id": "24888818", "label": "methods", "text": "Patients with MBC who did not have increased CTCs at baseline remained on initial therapy until progression ( arm A ) .", "sentence_id": 2}
+{"abstract_id": "24888818", "label": "methods", "text": "Patients with initially increased CTCs that decreased after @ days of therapy remained on initial therapy ( arm B ) .", "sentence_id": 3}
+{"abstract_id": "24888818", "label": "methods", "text": "Patients with persistently increased CTCs after @ days of therapy were randomly assigned to continue initial therapy ( arm C@ ) or change to an alternative chemotherapy ( arm C@ ) .", "sentence_id": 4}
+{"abstract_id": "24888818", "label": "results", "text": "Of @ eligible and evaluable patients , @ ( @ % ) did not have increased CTCs ( arm A ) .", "sentence_id": 5}
+{"abstract_id": "24888818", "label": "results", "text": "Of those with initially increased CTCs , @ ( @ % ) were not retested , @ were assigned to arm B , and @ were randomly assigned to arm C@ or C@ .", "sentence_id": 6}
+{"abstract_id": "24888818", "label": "results", "text": "No difference in median OS was observed between arm C@ and C@ ( @ and @ months , respectively ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24888818", "label": "results", "text": "CTCs were strongly prognostic .", "sentence_id": 8}
+{"abstract_id": "24888818", "label": "results", "text": "Median OS for arms A , B , and C ( C@ and C@ combined ) were @ months , @ months , and @ months , respectively ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24888818", "label": "conclusions", "text": "This study confirms the prognostic significance of CTCs in patients with MBC receiving first-line chemotherapy .", "sentence_id": 10}
+{"abstract_id": "24888818", "label": "conclusions", "text": "For patients with persistently increased CTCs after @ days of first-line chemotherapy , early switching to an alternate cytotoxic therapy was not effective in prolonging OS .", "sentence_id": 11}
+{"abstract_id": "24888818", "label": "conclusions", "text": "For this population , there is a need for more effective treatment than standard chemotherapy .", "sentence_id": 12}
+{"abstract_id": "24299553", "label": "background", "text": "Oral contraceptives ( OC ) are effective for birth control and have good cycle control and tolerability .", "sentence_id": 0}
+{"abstract_id": "24299553", "label": "background", "text": "However , the hormonal components could modify mood and libido .", "sentence_id": 1}
+{"abstract_id": "24299553", "label": "objective", "text": "The aim of this study is to evaluate the genital vascular effects and sexual behavior of an OC containing @ g ethinyl estradiol and @ mg drospirenone in comparison with a flexible combined contraceptive vaginal ring .", "sentence_id": 2}
+{"abstract_id": "24299553", "label": "methods", "text": "Forty women underwent a sonographic assessment of the clitoral anatomy and vascularization and were administered the McCoy Female Sexuality Questionnaire ( MFSQ ) and the Beck 's Depression Inventory questionnaire ( BDI ) .", "sentence_id": 3}
+{"abstract_id": "24299553", "label": "methods", "text": "Estradiol , androstenedione , testosterone , and SHBG were assayed .", "sentence_id": 4}
+{"abstract_id": "24299553", "label": "methods", "text": "Free Androgen Index ( FAI ) and Free Estrogen Index ( FEI ) were calculated .", "sentence_id": 5}
+{"abstract_id": "24299553", "label": "methods", "text": "The patients were randomly submitted to OC ( group I ; n = @ ) or vaginal ring ( group II ; n = @ ) .", "sentence_id": 6}
+{"abstract_id": "24299553", "label": "methods", "text": "Ultrasonographic clitoral volume , pulsatility index ( PI ) of dorsal clitoral arteries , MFSQ , BDI , and hormonal and biochemical assays were analyzed .", "sentence_id": 7}
+{"abstract_id": "24299553", "label": "results", "text": "After therapy , the testosterone levels were reduced in both groups , whereas estradiol decreased only in group I women .", "sentence_id": 8}
+{"abstract_id": "24299553", "label": "results", "text": "The SHBG increased in all the subjects , and both FAI and FEI decreased .", "sentence_id": 9}
+{"abstract_id": "24299553", "label": "results", "text": "The clitoral volume decreased in all the women .", "sentence_id": 10}
+{"abstract_id": "24299553", "label": "results", "text": "The PI of the dorsal clitoral artery increased only in patients on OC .", "sentence_id": 11}
+{"abstract_id": "24299553", "label": "results", "text": "The hormonal contraception was associated , in both studied groups , with a significant decrease of the two-factor Italian MFSQ score , which was more marked in OC users .", "sentence_id": 12}
+{"abstract_id": "24299553", "label": "results", "text": "In group I subjects , there was a reduction of the number of intercourse/week and a reduction of orgasm frequency during intercourse .", "sentence_id": 13}
+{"abstract_id": "24299553", "label": "results", "text": "The pain during intercourse worsened after OC use .", "sentence_id": 14}
+{"abstract_id": "24299553", "label": "results", "text": "The vaginal ring users reported a vaginal wetness .", "sentence_id": 15}
+{"abstract_id": "24299553", "label": "conclusions", "text": "Six-month treatment with hormonal contraception is associated with a diminished MFSQ score .", "sentence_id": 16}
+{"abstract_id": "24299553", "label": "conclusions", "text": "However , the frequency of sexual intercourse and orgasm was reduced only by the use of OC .", "sentence_id": 17}
+{"abstract_id": "24299553", "label": "conclusions", "text": "The OC use was associated with increased pain during intercourse .", "sentence_id": 18}
+{"abstract_id": "25442690", "label": "background", "text": "In @-@ , we did a randomised controlled trial in southern Nepal , and reported that children born to mothers taking multiple micronutrient supplements during pregnancy had a mean birthweight @ g greater than children born to mothers taking iron and folic acid supplements .", "sentence_id": 0}
+{"abstract_id": "25442690", "label": "background", "text": "Children born to mothers in the study group were a mean @ g heavier at @ years of age and their systolic blood pressure was a mean @ mm Hg lower than children born to mothers in the control group .", "sentence_id": 1}
+{"abstract_id": "25442690", "label": "background", "text": "We aimed to follow up the same children to mid-childhood ( age @ years ) to investigate whether these differences would be sustained .", "sentence_id": 2}
+{"abstract_id": "25442690", "label": "methods", "text": "For this follow-up study , we identified children from the original trial and measured anthropometry , body composition with bioelectrical impedance ( with population-specific isotope calibration ) , blood pressure , and renal dimensions by ultrasound .", "sentence_id": 3}
+{"abstract_id": "25442690", "label": "methods", "text": "We documented socioeconomic status , household food security , and air pollution .", "sentence_id": 4}
+{"abstract_id": "25442690", "label": "methods", "text": "Main outcomes of the follow-up at @ years were Z scores for weight-for-age , height-for-age , and body-mass index ( BMI ) - for-age according to WHO Child Growth Standards for children aged @-@ years , and blood pressure .", "sentence_id": 5}
+{"abstract_id": "25442690", "label": "methods", "text": "This study is registered with the International Standard Randomised Controlled Trial register , number ISRCTN@ .", "sentence_id": 6}
+{"abstract_id": "25442690", "label": "results", "text": "Between Sept @ , @ , and Dec @ , @ , we assessed @ children ( @ in the control group and @ in the intervention group ) .", "sentence_id": 7}
+{"abstract_id": "25442690", "label": "results", "text": "Unadjusted differences ( intervention minus control ) in Z scores were @ for weight-for-age ( @ % CI -@ to @ ) , @ in height-for-age ( -@ to @ ) , and @ in BMI-for-age ( -@ to @ ) .", "sentence_id": 8}
+{"abstract_id": "25442690", "label": "results", "text": "We recorded no difference in blood pressure .", "sentence_id": 9}
+{"abstract_id": "25442690", "label": "results", "text": "Adjusted differences were similar for all outcomes .", "sentence_id": 10}
+{"abstract_id": "25442690", "label": "conclusions", "text": "We recorded no differences in phenotype between children born to mothers who received antenatal multiple micronutrient or iron and folate supplements at age @ years .", "sentence_id": 11}
+{"abstract_id": "25442690", "label": "conclusions", "text": "Our findings did not extend to physiological differences or potential longer-term effects .", "sentence_id": 12}
+{"abstract_id": "24574085", "label": "background", "text": "Nasal saline irrigation is a safe treatment for chronic rhinosinusitis ; however , its effect on olfaction is unclear .", "sentence_id": 0}
+{"abstract_id": "24574085", "label": "background", "text": "Cyclic adenosine monophosphate ( cAMP ) is a key second messenger in the mechanism of olfaction and has been shown to be associated with smell function .", "sentence_id": 1}
+{"abstract_id": "24574085", "label": "background", "text": "In animal studies , olfactory cilia may be harvested by simple saline preparations .", "sentence_id": 2}
+{"abstract_id": "24574085", "label": "background", "text": "This study aimed to characterize the effect of nasal saline irrigation on smell function .", "sentence_id": 3}
+{"abstract_id": "24574085", "label": "methods", "text": "Volunteers with normal olfaction were randomized into a control or irrigation cohort .", "sentence_id": 4}
+{"abstract_id": "24574085", "label": "methods", "text": "In the initial appointment , subjects completed a University of Pennsylvania Smell Identification Test ( UPSIT ) and nasal samples were obtained by @ methods : the nasal curette and cytobrush .", "sentence_id": 5}
+{"abstract_id": "24574085", "label": "methods", "text": "The irrigation cohort performed daily nasal saline irrigations .", "sentence_id": 6}
+{"abstract_id": "24574085", "label": "methods", "text": "Both cohorts then returned in @ week .", "sentence_id": 7}
+{"abstract_id": "24574085", "label": "methods", "text": "The UPSIT and nasal cell collection were repeated , and each subject completed a subjective olfactory transition scale .", "sentence_id": 8}
+{"abstract_id": "24574085", "label": "methods", "text": "Nasal samples were processed for cAMP levels using a commercial assay .", "sentence_id": 9}
+{"abstract_id": "24574085", "label": "results", "text": "Thirty-two subjects were enrolled and randomized into each cohort .", "sentence_id": 10}
+{"abstract_id": "24574085", "label": "results", "text": "Control and postirrigation mean UPSIT scores were @ and @ ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24574085", "label": "results", "text": "No subjects reported a subjective smell loss .", "sentence_id": 12}
+{"abstract_id": "24574085", "label": "results", "text": "Ten pairs of nasal samples were assayed .", "sentence_id": 13}
+{"abstract_id": "24574085", "label": "results", "text": "Using the curette , control and postirrigation cAMP levels were @ and @ fmol / ( mg/mL ) , respectively ( p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24574085", "label": "results", "text": "Using the cytobrush , respective cAMP levels were @ and @ fmol / ( mg/mL ) , respectively ( p = @ ) .", "sentence_id": 15}
+{"abstract_id": "24574085", "label": "conclusions", "text": "Nasal saline irrigation has no subjective or objective effect on olfaction .", "sentence_id": 16}
+{"abstract_id": "24574085", "label": "conclusions", "text": "It also does not appear to affect cAMP levels , a potential marker of smell function .", "sentence_id": 17}
+{"abstract_id": "25516462", "label": "objective", "text": "To compare two electrosurgical techniques , straight-wire excision of transformation zone ( SWETZ ) with large loop excision of transformation zone , as a cone procedure ( LLETZ-cone ) , for the treatment of cervical intraepithelial neoplasia ( CIN ) , when disease is present at the cervical canal .", "sentence_id": 0}
+{"abstract_id": "25516462", "label": "methods", "text": "Randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25516462", "label": "methods", "text": "Two public hospitals , one in Rio de Janeiro , Brazil and one in Dublin , Ireland .", "sentence_id": 2}
+{"abstract_id": "25516462", "label": "methods", "text": "One hundred and three women with indication to treat CIN located at cervical canal .", "sentence_id": 3}
+{"abstract_id": "25516462", "label": "methods", "text": "Women were randomised to receive LLETZ-cone or SWETZ .", "sentence_id": 4}
+{"abstract_id": "25516462", "label": "results", "text": "Main outcome was the incidence of complete excision of disease at endocervical margin of the surgical specimen .", "sentence_id": 5}
+{"abstract_id": "25516462", "label": "results", "text": "Secondary outcomes were complete excision at ectocervical and stromal margins , time to complete the procedure , specimen fragmentation , blood loss and death after @ year .", "sentence_id": 6}
+{"abstract_id": "25516462", "label": "results", "text": "Fifty-two women were allocated to LLETZ-cone and @ to SWETZ .", "sentence_id": 7}
+{"abstract_id": "25516462", "label": "results", "text": "Ten women were lost for main outcome because of damaged specimens .", "sentence_id": 8}
+{"abstract_id": "25516462", "label": "results", "text": "Forty-two women in the LLETZ-cone group had free endocervical margin versus @ women in the SWETZ group ( relative risk @ , @ % confidence interval -LSB- @ % CI -RSB- @-@ @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25516462", "label": "results", "text": "For secondary outcomes related to margins , we observed a relative risk of @ ( @ % CI @-@ @ ; P = @ ) for ectocervical free margin .", "sentence_id": 10}
+{"abstract_id": "25516462", "label": "results", "text": "For free stromal margin , the relative risk was @ ( @ % CI @-@ @ ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25516462", "label": "results", "text": "No death was observed .", "sentence_id": 12}
+{"abstract_id": "25516462", "label": "conclusions", "text": "This study was inconclusive ; SWETZ and LLETZ-cone were equally effective to treat endocervical disease , with no difference in protecting against margin involvement .", "sentence_id": 13}
+{"abstract_id": "25516462", "label": "conclusions", "text": "Higher , but not severe , blood loss and longer surgical time were observed in the SWETZ group .", "sentence_id": 14}
+{"abstract_id": "25580087", "label": "background", "text": "Tissue hypoperfusion occurs frequently during surgery and may contribute to postoperative organ dysfunction .", "sentence_id": 0}
+{"abstract_id": "25580087", "label": "background", "text": "There is a need for perioperative treatment protocols aiming at improving tissue oxygenation ( StO@ ) .", "sentence_id": 1}
+{"abstract_id": "25580087", "label": "background", "text": "We hypothesised that intra-operative optimisation of StO@ improves tissue perfusion and thus reduces postoperative complications .", "sentence_id": 2}
+{"abstract_id": "25580087", "label": "background", "text": "Furthermore , we evaluated the feasibility of the optimisation algorithm used .", "sentence_id": 3}
+{"abstract_id": "25580087", "label": "methods", "text": "We randomized @ high-risk patients , all > @ years with ASA physical status III , who underwent major abdominal surgery under standardized balanced general anesthesia combined with epidural analgesia .", "sentence_id": 4}
+{"abstract_id": "25580087", "label": "methods", "text": "Throughout surgery StO@ was monitored at the thenar eminence using near-infrared spectroscopy .", "sentence_id": 5}
+{"abstract_id": "25580087", "label": "methods", "text": "All patients were treated according to a standard care algorithm .", "sentence_id": 6}
+{"abstract_id": "25580087", "label": "methods", "text": "In addition , patients in the intervention group were treated with dobutamine if necessary to keep or raise StO@ % .", "sentence_id": 7}
+{"abstract_id": "25580087", "label": "methods", "text": "Data were recorded continuously and complications were recorded during hospital stay with a maximum of @ days .", "sentence_id": 8}
+{"abstract_id": "25580087", "label": "results", "text": "The number of complications was not significantly different between groups ( @ vs @ ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25580087", "label": "results", "text": "Eleven patients in the intervention group had no complication , versus @ in the control group .", "sentence_id": 10}
+{"abstract_id": "25580087", "label": "results", "text": "There was no significant difference between groups in length of stay in ICU or in hospital .", "sentence_id": 11}
+{"abstract_id": "25580087", "label": "results", "text": "Only ten patients in the intervention group received dobutamine .", "sentence_id": 12}
+{"abstract_id": "25580087", "label": "results", "text": "Administration of dobutamine resulted in a moderate @ -LSB- -@ to @ -RSB- % increase of StO@ .", "sentence_id": 13}
+{"abstract_id": "25580087", "label": "results", "text": "The overall protocol adherence was @ % .", "sentence_id": 14}
+{"abstract_id": "25580087", "label": "conclusions", "text": "No statistically significant difference in outcome was realized through intraoperative optimization of StO@ values in this pilot study .", "sentence_id": 15}
+{"abstract_id": "25580087", "label": "conclusions", "text": "The protocol used may be considered feasible for clinical practice .", "sentence_id": 16}
+{"abstract_id": "25580087", "label": "conclusions", "text": "Further research is obligatory to define both the optimal StO@ threshold and intervention to treat tissue hypoperfusion .", "sentence_id": 17}
+{"abstract_id": "25421015", "label": "objective", "text": "To compare the pharmacodynamic effects of the highest approved doses of the sodium glucose co-transporter @ ( SGLT@ ) inhibitors canagliflozin and dapagliflozin on urinary glucose excretion ( UGE ) , renal threshold for glucose excretion ( RTG ) and postprandial plasma glucose ( PPG ) excursion in healthy participants in a randomized , double-blind , two-period crossover study .", "sentence_id": 0}
+{"abstract_id": "25421015", "label": "methods", "text": "In each treatment period , participants ( n = @ ) received canagliflozin @mg or dapagliflozin @mg for @days ( @min before breakfast ) .", "sentence_id": 1}
+{"abstract_id": "25421015", "label": "methods", "text": "A mixed-meal tolerance test ( @kcal ; @g glucose ) was performed at baseline and on day @ of each treatment period to assess changes in incremental PPG ( PPGAUC@-@ h ) .", "sentence_id": 2}
+{"abstract_id": "25421015", "label": "methods", "text": "We measured @-h UGE and plasma glucose on day @ to determine @-h mean RTG .", "sentence_id": 3}
+{"abstract_id": "25421015", "label": "results", "text": "Canagliflozin @mg and dapagliflozin @mg had similar effects on UGE and RTG for @h after dosing , but canagliflozin was associated with higher UGE and greater RTG reductions for the remainder of the day .", "sentence_id": 4}
+{"abstract_id": "25421015", "label": "results", "text": "Mean @-h UGE was @ % higher with canagliflozin than with dapagliflozin ( @ vs. @ g ) , and @-h mean RTG was @ mmol/l ( @ mg/dl ) lower with canagliflozin than with dapagliflozin ( @ vs. @ mmol/l ; p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25421015", "label": "results", "text": "Dapagliflozin had no effect on PPG excursion ; canagliflozin delayed and reduced PPG excursion ( between-treatment difference in PPGAUC@-@ h from baseline expressed as a percentage of baseline mean , -@ % ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25421015", "label": "results", "text": "Canagliflozin and dapagliflozin were generally well tolerated .", "sentence_id": 7}
+{"abstract_id": "25421015", "label": "conclusions", "text": "In healthy participants , canagliflozin @mg provided greater @-h UGE , a lower RTG and smaller PPG excursions than dapagliflozin @mg .", "sentence_id": 8}
+{"abstract_id": "25933031", "label": "background", "text": "In postmenopausal osteoporotic women , denosumab fully inhibits teriparatide-induced bone resorption at approved doses .", "sentence_id": 0}
+{"abstract_id": "25933031", "label": "background", "text": "This property of denosumab is distinct from that of alendronate and likely contributes to the efficacy of combination denosumab and teriparatide therapy .", "sentence_id": 1}
+{"abstract_id": "25933031", "label": "background", "text": "Whether denosumab fully inhibits bone resorption when challenged by a higher dose of teriparatide is unknown .", "sentence_id": 2}
+{"abstract_id": "25933031", "label": "objective", "text": "We aimed to define the comparative ability of denosumab and alendronate to block the acute proresorptive effects of high-dose teriparatide .", "sentence_id": 3}
+{"abstract_id": "25933031", "label": "methods", "text": "In this randomized controlled trial , bone resorption ( serum C-telopeptide -LSB- CTX -RSB- ) was measured in @ postmenopausal women prior to and @ hours after a single @-g sc teriparatide injection .", "sentence_id": 4}
+{"abstract_id": "25933031", "label": "methods", "text": "Subjects then received either a single injection of denosumab @ mg or oral alendronate @ mg weekly for @ weeks .", "sentence_id": 5}
+{"abstract_id": "25933031", "label": "methods", "text": "After @ weeks , serum CTX was again measured before and @ hours after a teriparatide a @-g injection .", "sentence_id": 6}
+{"abstract_id": "25933031", "label": "results", "text": "The primary outcome was the between-group difference in the teriparatide-induced change in CTX from baseline to week @ .", "sentence_id": 7}
+{"abstract_id": "25933031", "label": "results", "text": "At baseline , @ g of teriparatide induced similar @-hour increases in mean CTX in both groups ( alendronate @ % @ % , denosumab @ % @ % ) .", "sentence_id": 8}
+{"abstract_id": "25933031", "label": "results", "text": "After @ weeks , teriparatide was still able to stimulate bone resorption in women treated with alendronate ( mean CTX increase of @ % @ % ) but not in women treated with denosumab ( -@ % @ % ; P < @ for between group comparison ) .", "sentence_id": 9}
+{"abstract_id": "25933031", "label": "conclusions", "text": "Denosumab , but not alendronate , fully inhibits the ability of high-dose teriparatide to increase bone resorption acutely .", "sentence_id": 10}
+{"abstract_id": "25933031", "label": "conclusions", "text": "These results suggest that combining denosumab with a more potent anabolic stimulus may result in greater separation between bone resorption and formation and hence greater increases in bone mass .", "sentence_id": 11}
+{"abstract_id": "25443864", "label": "background", "text": "This paper reports a cluster analysis of a sample recruited from a randomized controlled trial that explored the effect of using a life story work approach to improve the psychological outcomes of older people in the community .", "sentence_id": 0}
+{"abstract_id": "25443864", "label": "methods", "text": "@ subjects from community centers were included in this analysis .", "sentence_id": 1}
+{"abstract_id": "25443864", "label": "methods", "text": "After statistical testing , @ seniors were assigned to the active ageing ( AG ) cluster and @ to the inactive ageing ( IG ) cluster .", "sentence_id": 2}
+{"abstract_id": "25443864", "label": "results", "text": "Those in the AG were younger and healthier , with fewer chronic diseases and fewer depressive symptoms than those in the IG .", "sentence_id": 3}
+{"abstract_id": "25443864", "label": "results", "text": "They were more satisfied with their lives , and had higher self-esteem .", "sentence_id": 4}
+{"abstract_id": "25443864", "label": "results", "text": "They met with their family members more frequently , they engaged in more leisure activities and were more likely to have the ability to move freely .", "sentence_id": 5}
+{"abstract_id": "25443864", "label": "conclusions", "text": "In summary , active ageing was observed in people with better health and functional performance .", "sentence_id": 6}
+{"abstract_id": "25443864", "label": "conclusions", "text": "Our results echoed the limited findings reported in the literature .", "sentence_id": 7}
+{"abstract_id": "25840501", "label": "background", "text": "Rehabilitation provided through home visits is part of the continuum of care after discharge from hospital following total knee arthroplasty ( TKA ) .", "sentence_id": 0}
+{"abstract_id": "25840501", "label": "background", "text": "As demands for rehabilitation at home are growing and becoming more difficult to meet , in-home telerehabilitation has been proposed as an alternate service delivery method .", "sentence_id": 1}
+{"abstract_id": "25840501", "label": "background", "text": "However , there is a need for robust data concerning both the effectiveness and the cost of dispensing in-home telerehabilitation .", "sentence_id": 2}
+{"abstract_id": "25840501", "label": "objective", "text": "The objective of this study was to document , analyze , and compare real costs of two service delivery methods : in-home telerehabilitation and conventional home visits .", "sentence_id": 3}
+{"abstract_id": "25840501", "label": "methods", "text": "The economic analysis was conducted as part of a multicenter randomized controlled trial ( RCT ) on telerehabilitation for TKA , and involved data from @ patients , post-TKA .", "sentence_id": 4}
+{"abstract_id": "25840501", "label": "methods", "text": "Twice a week for @ weeks , participants received supervised physiotherapy via two delivery methods , depending on their study group allocation : in-home telerehabilitation ( TELE ) and home-visit rehabilitation ( VISIT ) .", "sentence_id": 5}
+{"abstract_id": "25840501", "label": "methods", "text": "Patients were recruited from eight hospitals in the province of Quebec , Canada .", "sentence_id": 6}
+{"abstract_id": "25840501", "label": "methods", "text": "The TELE group intervention was delivered by videoconferencing over high-speed Internet .", "sentence_id": 7}
+{"abstract_id": "25840501", "label": "methods", "text": "The VISIT group received the same intervention at home .", "sentence_id": 8}
+{"abstract_id": "25840501", "label": "methods", "text": "Costs related to the delivery of the two services ( TELE and VISIT ) were calculated .", "sentence_id": 9}
+{"abstract_id": "25840501", "label": "methods", "text": "Student 's t tests were used to compare costs per treatment between the two groups .", "sentence_id": 10}
+{"abstract_id": "25840501", "label": "methods", "text": "To take distance into account , the two treatment groups were compared within distance strata using two-way analyses of variance ( ANOVAs ) .", "sentence_id": 11}
+{"abstract_id": "25840501", "label": "results", "text": "The mean cost of a single session was Can $ @ for the VISIT group ( SD $ @ ) and $ @ for the TELE group ( SD $ @ ) .", "sentence_id": 12}
+{"abstract_id": "25840501", "label": "results", "text": "When comparing both groups , real total cost analysis showed a cost differential in favor of the TELE group ( TELE minus VISIT : - $ @ , @ % CI - $ @ to - $ @ ) .", "sentence_id": 13}
+{"abstract_id": "25840501", "label": "results", "text": "However , when the patient 's home was located less than @ km round-trip from the health care center , the difference in costs between TELE and VISIT treatments was not significant ( P = @ , @ , and @ for the < @ , @-@ , and @-@ km strata , respectively ) .", "sentence_id": 14}
+{"abstract_id": "25840501", "label": "results", "text": "The cost of TELE treatments was lower than VISIT treatments when the distance was @ km or more ( @-@ km : $ @ < $ @ , P = @ ; @ km : $ @ < $ @ , P < @ ) .", "sentence_id": 15}
+{"abstract_id": "25840501", "label": "conclusions", "text": "To our knowledge , this is the first study of the actual costs of in-home telerehabilitation covering all subcosts of telerehabilitation and distance between the health care center and the patient 's home .", "sentence_id": 16}
+{"abstract_id": "25840501", "label": "conclusions", "text": "The cost for a single session of in-home telerehabilitation compared to conventional home-visit rehabilitation was lower or about the same , depending on the distance between the patient 's home and health care center .", "sentence_id": 17}
+{"abstract_id": "25840501", "label": "conclusions", "text": "Under the controlled conditions of an RCT , a favorable cost differential was observed when the patient was more than @ km from the provider .", "sentence_id": 18}
+{"abstract_id": "25840501", "label": "conclusions", "text": "Stakeholders and program planners can use these data to guide decisions regarding introducing telerehabilitation as a new service in their clinic .", "sentence_id": 19}
+{"abstract_id": "24240354", "label": "objective", "text": "This study aimed to determine the probability and risk factors for developing a corneal inflammatory event ( CIE ) during daily wear of lotrafilcon A silicone hydrogel contact lenses .", "sentence_id": 0}
+{"abstract_id": "24240354", "label": "methods", "text": "Eligible participants ( n = @ ) were fit with lotrafilcon A lenses for daily wear and followed up for @ months .", "sentence_id": 1}
+{"abstract_id": "24240354", "label": "methods", "text": "Participants were randomized to either a polyhexamethylene biguanide-preserved multipurpose solution or a one-step peroxide disinfection system .", "sentence_id": 2}
+{"abstract_id": "24240354", "label": "methods", "text": "The main exposures of interest were bacterial contamination of lenses , cases , lid margins , and ocular surface .", "sentence_id": 3}
+{"abstract_id": "24240354", "label": "methods", "text": "Kaplan-Meier ( KM ) plots were used to estimate the cumulative unadjusted probability of remaining free from a CIE , and multivariate Cox proportional hazards regression was used to model the hazard of experiencing a CIE.", "sentence_id": 4}
+{"abstract_id": "24240354", "label": "results", "text": "The KM unadjusted cumulative probability of remaining free from a CIE for both lens care groups combined was @ % ( @ % confidence interval -LSB- CI -RSB- , @ to @ % ) .", "sentence_id": 5}
+{"abstract_id": "24240354", "label": "results", "text": "There was one participant with microbial keratitis , five participants with asymptomatic infiltrates , and seven participants with contact lens peripheral ulcers , providing KM survival estimates of @ % ( @ % CI , @ to @ % ) and @ % ( @ % CI , @ to @ % ) for remaining free from noninfectious and symptomatic CIEs , respectively .", "sentence_id": 6}
+{"abstract_id": "24240354", "label": "results", "text": "The presence of substantial ( > @ colony-forming units ) coagulase-negative staphylococci bioburden on lid margins was associated with about a five-fold increased risk for the development of a CIE ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24240354", "label": "conclusions", "text": "The probability of experiencing a CIE during daily wear of lotrafilcon A contact lenses is low , and symptomatic CIEs are rare .", "sentence_id": 8}
+{"abstract_id": "24240354", "label": "conclusions", "text": "Patient factors , such as high levels of bacterial bioburden on lid margins , contribute to the development of noninfectious CIEs during daily wear of silicone hydrogel lenses .", "sentence_id": 9}
+{"abstract_id": "25503447", "label": "background", "text": "Home-based exercise has been shown to provide benefits in terms of physical capacity in the general population , but has been scarcely investigated in patients with chronic kidney disease ( CKD ) .", "sentence_id": 0}
+{"abstract_id": "25503447", "label": "objective", "text": "To evaluate the impact of a home-based aerobic training on the cardiopulmonary and functional capacities of overweight non-dialysis-dependent patients with CKD ( NDD-CKD ) .", "sentence_id": 1}
+{"abstract_id": "25503447", "label": "methods", "text": "Twenty-nine sedentary patients ( @ @ years , BMI = @ @ kg/m ( @ ) , eGFR = @ @ mL/min/@ @ m ( @ ) ) were randomly assigned to a home-based exercise group ( n = @ ) or to a control group ( n = @ ) that remained without performing exercise .", "sentence_id": 2}
+{"abstract_id": "25503447", "label": "methods", "text": "Aerobic training was performed three times per week for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25503447", "label": "methods", "text": "A cardiopulmonary exercise test , functional capacity and clinical parameters were evaluated .", "sentence_id": 4}
+{"abstract_id": "25503447", "label": "results", "text": "A significant increase , ranging from @ to @ % , was observed in the cardiopulmonary capacity parameters , such as maximal ventilation ( p = @ ) , VO@peak ( p = @ ) , ventilatory threshold ( p = @ ) and respiratory compensation point ( p < @ ) , of the exercise group .", "sentence_id": 5}
+{"abstract_id": "25503447", "label": "results", "text": "A simultaneous improvement in the functional capacity tests -LSB- @-min walk test ( p < @ ) , time up and go test ( p < @ ) , arm curl test ( p < @ ) , sit and stand test ( p < @ ) , @-min step test ( p < @ ) and back scratch test ( p = @ ) -RSB- was also found in patients who were submitted to the exercise .", "sentence_id": 6}
+{"abstract_id": "25503447", "label": "results", "text": "Exercised patients experienced a decrease in systolic and diastolic blood pressure , average @ % ( p < @ ) and @ % ( p = @ ) , respectively , and a trend toward improved renal function ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25503447", "label": "results", "text": "No change in any parameter was found in the control group during the follow-up .", "sentence_id": 8}
+{"abstract_id": "25503447", "label": "conclusions", "text": "The home-based aerobic exercise program was feasible , safe and effective for the improvement in the cardiopulmonary and functional capacities of overweight NDD-CKD patients .", "sentence_id": 9}
+{"abstract_id": "25481454", "label": "objective", "text": "To assess the effectiveness of the Healthy School and Drugs ( HSD ) program for secondary schools on the development of substance use among Dutch early adolescents and to explore whether boys , adolescents of lower educational backgrounds , or adolescents high on personality risk traits , would benefit more from the HSD program than others .", "sentence_id": 0}
+{"abstract_id": "25481454", "label": "methods", "text": "Randomized clustered trial with two intervention conditions ( i.e. , lessons and integral ) among a general population of adolescents in the Netherlands .", "sentence_id": 1}
+{"abstract_id": "25481454", "label": "methods", "text": "A total of @ students of @ Dutch secondary schools .", "sentence_id": 2}
+{"abstract_id": "25481454", "label": "methods", "text": "Structured digital questionnaires were administered pre-intervention and at @ , @ , and @months follow-ups .", "sentence_id": 3}
+{"abstract_id": "25481454", "label": "methods", "text": "The outcome measure was the rate of change in substance use across follow-ups .", "sentence_id": 4}
+{"abstract_id": "25481454", "label": "methods", "text": "Differential effectiveness of the HSD program was examined for sex , educational level , and personality traits .", "sentence_id": 5}
+{"abstract_id": "25481454", "label": "results", "text": "Our results show no HSD intervention effects on the development of substance use .", "sentence_id": 6}
+{"abstract_id": "25481454", "label": "results", "text": "Sex , education level , and personality characteristics of the participants did not moderate the intervention effects .", "sentence_id": 7}
+{"abstract_id": "25481454", "label": "conclusions", "text": "The absence of effects of the Healthy School and Drugs program on the development of substance use indicates that the program should be renewed and redeveloped .", "sentence_id": 8}
+{"abstract_id": "24853922", "label": "methods", "text": "Cross-sectional diagnostic accuracy study .", "sentence_id": 0}
+{"abstract_id": "24853922", "label": "objective", "text": "To investigate the relationship between history and physical examination findings and the outcome of electrodiagnostic testing in patients with sciatica referred to physical therapy .", "sentence_id": 1}
+{"abstract_id": "24853922", "label": "background", "text": "Electrodiagnostic testing is routinely used to evaluate patients with sciatica .", "sentence_id": 2}
+{"abstract_id": "24853922", "label": "background", "text": "Recent evidence suggests that the presence of radiculopathy identified with electrodiagnostic testing may predict better functional outcomes in these patients .", "sentence_id": 3}
+{"abstract_id": "24853922", "label": "background", "text": "While some patient history and physical examination findings have been shown to predict the presence of disc herniation or neurological insult , little is known about their relationship to the results of electrodiagnostic testing .", "sentence_id": 4}
+{"abstract_id": "24853922", "label": "methods", "text": "Electrodiagnostic testing was performed on @ patients with sciatica who participated in a randomized trial that compared different physical therapy interventions .", "sentence_id": 5}
+{"abstract_id": "24853922", "label": "methods", "text": "The diagnostic gold standard was the presence or absence of radiculopathy , based on the results of the needle electromyographic examination .", "sentence_id": 6}
+{"abstract_id": "24853922", "label": "methods", "text": "Diagnostic sensitivity and specificity values were calculated , along with corresponding likelihood ratios , for select patient history and physical examination variables .", "sentence_id": 7}
+{"abstract_id": "24853922", "label": "results", "text": "No significant relationship was found between select patient history and physical examination findings , analyzed individually or in combination , and the outcome of electrodiagnostic testing .", "sentence_id": 8}
+{"abstract_id": "24853922", "label": "results", "text": "Diagnostic sensitivity values ranged from @ ( @ % confidence interval -LSB- CI -RSB- : @ , @ ) to a high of @ ( @ % CI : @ , @ ) , and specificity values ranged from @ ( @ % CI : @ , @ ) to a high of @ ( @ % CI : @ , @ ) .", "sentence_id": 9}
+{"abstract_id": "24853922", "label": "results", "text": "Positive likelihood ratios ranged from @ ( @ % CI : @ , @ ) to a high of @ ( @ % CI : @ , @ ) , and negative likelihood ratios ranged from @ ( @ % CI : @ , @ ) to a low of @ ( @ % CI : @ , @ ) .", "sentence_id": 10}
+{"abstract_id": "24853922", "label": "conclusions", "text": "In this investigation , the relationship between patient history and physical examination findings and the outcome of electrodiagnostic testing among patients with sciatica was not found to be statistically significant or clinically meaningful .", "sentence_id": 11}
+{"abstract_id": "24853922", "label": "conclusions", "text": "However , given the small sample size and corresponding large CIs , these results should be considered with caution , recognizing that some of the history and physical examination variables may prove useful in future research .", "sentence_id": 12}
+{"abstract_id": "24853922", "label": "conclusions", "text": "These findings suggest that electrodiagnostic testing is essential to identify the subgroup of patients with sciatica who have measurable nerve injury consistent with radiculopathy , which may be an important prognostic factor for recovery .", "sentence_id": 13}
+{"abstract_id": "24853922", "label": "conclusions", "text": "Level of Evidence Diagnosis , level @b - .", "sentence_id": 14}
+{"abstract_id": "24853922", "label": "conclusions", "text": "J Orthop Sports Phys Ther @ ; @ ( @ ) :@ -@ .", "sentence_id": 15}
+{"abstract_id": "24853922", "label": "conclusions", "text": "Epub @ May @ .", "sentence_id": 16}
+{"abstract_id": "24853922", "label": "conclusions", "text": "doi :@ / jospt @ .", "sentence_id": 17}
+{"abstract_id": "25927536", "label": "background", "text": "This analysis is based on a survey questionnaire designed to describe medical educators ' views of psychiatry and psychiatrists .", "sentence_id": 0}
+{"abstract_id": "25927536", "label": "background", "text": "Our goals in this paper were to assess the psychometric properties of the survey questions by ( a ) using exploratory factor analysis to identify the basic factor structure underlying @ survey items ; ( b ) testing the resulting factor structure using confirmatory factor analysis ; and ( c ) assessing the internal reliability of each identified factor .", "sentence_id": 1}
+{"abstract_id": "25927536", "label": "background", "text": "To our knowledge , this is the first attempt to use these techniques to psychometrically assess a scale measuring the strength of stigma that medical educators attached to psychiatry .", "sentence_id": 2}
+{"abstract_id": "25927536", "label": "methods", "text": "Survey data were collected from a random sample of @,@ teaching faculty in @ academic teaching sites in @ countries .", "sentence_id": 3}
+{"abstract_id": "25927536", "label": "methods", "text": "We conducted exploratory and confirmatory factor analysis to identify the scale structure and Cronbach 's alpha to assess internal consistency of the resulting scales .", "sentence_id": 4}
+{"abstract_id": "25927536", "label": "results", "text": "Results showed that a two-factor solution was the best fit for the data .", "sentence_id": 5}
+{"abstract_id": "25927536", "label": "results", "text": "Following exploratory factor analysis , we conducted confirmatory factor analysis on a split half of the sample .", "sentence_id": 6}
+{"abstract_id": "25927536", "label": "results", "text": "Results highlighted several items with low loadings .", "sentence_id": 7}
+{"abstract_id": "25927536", "label": "results", "text": "Excluding factors with low correlations and allowing for several correlated variances resulted in a good fitting model explaining @ % of the variance in the data .", "sentence_id": 8}
+{"abstract_id": "25927536", "label": "conclusions", "text": "We identified two unidimensional scales .", "sentence_id": 9}
+{"abstract_id": "25927536", "label": "conclusions", "text": "The Images Scale contained @ items measuring stereotypic content concerning psychiatry and psychiatrists .", "sentence_id": 10}
+{"abstract_id": "25927536", "label": "conclusions", "text": "The Efficacy of Psychiatry Scale contained @ items addressing perceptions of the challenges and effectiveness of psychiatry as a discipline .", "sentence_id": 11}
+{"abstract_id": "25925875", "label": "objective", "text": "To evaluate the efficacy of Ginkgo biloba as a complementary therapy for attention-deficit/hyperactivity disorder ( ADHD ) .", "sentence_id": 0}
+{"abstract_id": "25925875", "label": "methods", "text": "Children and adolescents with ADHD received methylphenidate ( @-@ mg/day ) plus either G. biloba ( @-@ mg/day ) or placebo for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25925875", "label": "methods", "text": "Parent and teacher forms of the ADHD Rating Scale-IV ( ADHD-RS-IV ) were completed at baseline , week @ , and week @ .", "sentence_id": 2}
+{"abstract_id": "25925875", "label": "methods", "text": "Treatment response was defined as @ % improvement from baseline in the ADHD-RS-IV .", "sentence_id": 3}
+{"abstract_id": "25925875", "label": "results", "text": "Compared with placebo , more reduction was observed with G. biloba regarding ADHD-RS-IV parent rating inattention score ( -@ @ vs. -@ @ , P < @ ) and total score ( -@ @ vs. -@ @ , P = @ ) as well as teacher rating inattention score ( -@ @ vs. -@ @ , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25925875", "label": "results", "text": "Response rate was higher with G. biloba compared with placebo based on parent rating ( @ % vs. @ % , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25925875", "label": "conclusions", "text": "The G. biloba is an effective complementary treatment for ADHD .", "sentence_id": 6}
+{"abstract_id": "25925875", "label": "conclusions", "text": "Further studies with longer treatment duration are warranted in this regard .", "sentence_id": 7}
+{"abstract_id": "25925875", "label": "conclusions", "text": "IRCT@N@ .", "sentence_id": 8}
+{"abstract_id": "24424629", "label": "objective", "text": "To evaluate the long-term efficacy of pain reduction by two dose fractionation schedules used for low-dose radiotherapy of painful elbow syndrome .", "sentence_id": 0}
+{"abstract_id": "24424629", "label": "methods", "text": "Between February @ and February @ , @evaluable patients were recruited for this prospective trial .", "sentence_id": 1}
+{"abstract_id": "24424629", "label": "methods", "text": "All patients received low-dose orthovoltage radiotherapy .", "sentence_id": 2}
+{"abstract_id": "24424629", "label": "methods", "text": "One course consisted of @fractions in @weeks .", "sentence_id": 3}
+{"abstract_id": "24424629", "label": "methods", "text": "In the case of insufficient pain remission after @weeks , a second course was administered .", "sentence_id": 4}
+{"abstract_id": "24424629", "label": "methods", "text": "Patients were randomly assigned to one of two groups to receive single doses of either @ or @ Gy .", "sentence_id": 5}
+{"abstract_id": "24424629", "label": "methods", "text": "Endpoint was pain reduction .", "sentence_id": 6}
+{"abstract_id": "24424629", "label": "methods", "text": "Pain was measured before radiotherapy , as well as immediately after ( early response ) , @weeks after ( delayed response ) and approximately @years after ( long-term response ) completion of radiotherapy using a questionnaire-based visual analogue scale ( VAS ) and a comprehensive pain score ( CPS ) .", "sentence_id": 7}
+{"abstract_id": "24424629", "label": "results", "text": "Median follow-up was @months ( range @-@months ) .", "sentence_id": 8}
+{"abstract_id": "24424629", "label": "results", "text": "The overall early , delayed and long-term response rates for all patients were @ , @and @ % , respectively .", "sentence_id": 9}
+{"abstract_id": "24424629", "label": "results", "text": "The mean VAS scores before treatment and those for early , delayed and long-term response in the @ - and @-Gy groups were @ and @ ( p = @ ) ; @ and @ ( p = @ ) ; @ and @ ( p = @ ) and @ and @ ( p = @ ) , respectively .", "sentence_id": 10}
+{"abstract_id": "24424629", "label": "results", "text": "The mean CPS values before treatment and those for early , delayed and long-term response were @ and @ ( p = @ ) ; @ and @ ( p = @ ) ; @ and @ ( p = @ ) and @ and @ ( p = @ ) , respectively .", "sentence_id": 11}
+{"abstract_id": "24424629", "label": "results", "text": "No significant differences in the quality of the long-term response were found between the @ - and @-Gy arms ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24424629", "label": "conclusions", "text": "Low-dose radiotherapy is an effective treatment for the management of benign painful elbow syndrome .", "sentence_id": 13}
+{"abstract_id": "24424629", "label": "conclusions", "text": "For radiation protection reasons , the dose for a radiotherapy series should not exceed @ Gy .", "sentence_id": 14}
+{"abstract_id": "25037854", "label": "background", "text": "A recent clinical trial could not find differences between anti-inflammatory drugs , antibiotics and placebo in shortening the duration of symptoms in acute bronchitis .", "sentence_id": 0}
+{"abstract_id": "25037854", "label": "objective", "text": "To investigate if C-reactive protein ( CRP ) concentrations at presentation are predictive of symptom resolution in these patients .", "sentence_id": 1}
+{"abstract_id": "25037854", "label": "methods", "text": "We performed a secondary analysis of the data from a placebo-controlled , randomized clinical trial carried out in primary care .", "sentence_id": 2}
+{"abstract_id": "25037854", "label": "methods", "text": "Patients from @ to @ years of age presenting a respiratory tract infection of < @ week of evolution , with cough as the predominant symptom and the presence of discoloured expectoration , were enrolled in the study .", "sentence_id": 3}
+{"abstract_id": "25037854", "label": "methods", "text": "On the baseline visit , CRP was determined in capillary blood and a five-item symptom diary was given .", "sentence_id": 4}
+{"abstract_id": "25037854", "label": "methods", "text": "Patients were followed up to @ days .", "sentence_id": 5}
+{"abstract_id": "25037854", "label": "methods", "text": "The main outcome measure was the number of days with persistent cough .", "sentence_id": 6}
+{"abstract_id": "25037854", "label": "results", "text": "A total of @ subjects fulfilled all the criteria for the efficacy analysis and had undergone the CRP test ; of these , @ % presented a CRP value < @ mg/l and @ % presented < @ mg/l .", "sentence_id": 7}
+{"abstract_id": "25037854", "label": "results", "text": "There were no significant differences in the median duration of cough : @ days among patients with CRP concentrations < @ mg/l -LSB- @ % confidence interval ( CI ) : @-@ days -RSB- , @ days among those with concentrations ranging from @ to @ mg/l ( @ % CI : @-@ ) and @ days in those with CRP > @ mg/l ( @ % CI : @-@ ) ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25037854", "label": "conclusions", "text": "Among patients with uncomplicated acute bronchitis and discoloured sputum , the CRP concentrations at presentation are not helpful for predicting symptom resolution .", "sentence_id": 9}
+{"abstract_id": "24837298", "label": "objective", "text": "Proxy measures are an alternative source of data for care home residents who are unable to complete the health utility measure , but the agreement levels between residents and care home staff for the EQ-@D have not been investigated previously .", "sentence_id": 0}
+{"abstract_id": "24837298", "label": "objective", "text": "The objective of the present study was to examine the inter-rater agreement levels for the reporting of EQ-@D by care home residents and staff , adjusting for the impact of clustering .", "sentence_id": 1}
+{"abstract_id": "24837298", "label": "methods", "text": "The data consist of EQ-@D scores for @ pairs of care home residents and proxies and quality-adjusted life-years ( QALYs ) for @ pairs .", "sentence_id": 2}
+{"abstract_id": "24837298", "label": "methods", "text": "Cluster-adjusted agreement was compared for the domains , index scores , and QALYs from the EQ-@D .", "sentence_id": 3}
+{"abstract_id": "24837298", "label": "methods", "text": "Factors influencing index score agreement are also described .", "sentence_id": 4}
+{"abstract_id": "24837298", "label": "results", "text": "The results show poor to fair agreement at the domain level ( cluster-adjusted Kappa -@ to @ ) and moderate agreement at the score level ( cluster-adjusted intra-class correlation coefficient -LSB- ICC -RSB- @-@ @ ) and for QALYs ( cluster-adjusted ICC @ ) .", "sentence_id": 5}
+{"abstract_id": "24837298", "label": "results", "text": "A higher likelihood of depression and lower cognitive impairment were both associated with smaller discrepancy between proxy and self-completed scores .", "sentence_id": 6}
+{"abstract_id": "24837298", "label": "conclusions", "text": "Proxies appear to be an acceptable source of data for index scores and QALYs but may be less reliable if individual domains are considered .", "sentence_id": 7}
+{"abstract_id": "25199526", "label": "background", "text": "Knee osteoarthritis ( OA ) causes pain and long-term disability with annual healthcare costs exceeding $ @ billion in the United States .", "sentence_id": 0}
+{"abstract_id": "25199526", "label": "background", "text": "Few medical remedies effectively influence the course of the disease .", "sentence_id": 1}
+{"abstract_id": "25199526", "label": "background", "text": "Finding effective treatments to maintain function and quality of life in patients with knee OA is one of the national priorities identified by the Institute of Medicine .", "sentence_id": 2}
+{"abstract_id": "25199526", "label": "background", "text": "We are currently conducting the first comparative effectiveness and cost-effectiveness randomized trial of Tai Chi versus a physical-therapy regimen in a sample of patients with symptomatic and radiographically confirmed knee OA .", "sentence_id": 3}
+{"abstract_id": "25199526", "label": "background", "text": "This article describes the design and conduct of this trial .", "sentence_id": 4}
+{"abstract_id": "25199526", "label": "methods", "text": "A single-center , @-week , comparative effectiveness randomized controlled trial of Tai Chi versus a standardized physical-therapy regimen is being conducted at an urban tertiary medical center in Boston , Massachusetts .", "sentence_id": 5}
+{"abstract_id": "25199526", "label": "methods", "text": "The study population consists of adults@ years of age with symptomatic and radiographic knee OA ( American College of Rheumatology criteria ) .", "sentence_id": 6}
+{"abstract_id": "25199526", "label": "methods", "text": "Participants are randomly allocated to either @ weeks of Tai Chi ( @x/week ) or Physical Therapy ( @x/week for @ weeks , followed by @ weeks of rigorously monitored home exercise ) .", "sentence_id": 7}
+{"abstract_id": "25199526", "label": "methods", "text": "The primary outcome measure is pain ( Western Ontario and McMaster Universities WOMAC ) subscale at @ weeks .", "sentence_id": 8}
+{"abstract_id": "25199526", "label": "methods", "text": "Secondary outcomes include WOMAC stkiffness and function domain scores , lower extremity strength and power , functional balance , physical performance tests , psychological and psychosocial functioning , durability effects , health related quality of life , and healthcare utilization at @ , @ and @ weeks .", "sentence_id": 9}
+{"abstract_id": "25199526", "label": "conclusions", "text": "This study will be the first randomized comparative-effectiveness and cost-effectiveness trial of Tai Chi versus Physical Therapy in a large symptomatic knee OA population with long-term follow up .", "sentence_id": 10}
+{"abstract_id": "25199526", "label": "conclusions", "text": "We present here a robust and well-designed randomized comparative-effectiveness trial that also explores multiple outcomes to elucidate the potential mechanisms of mind-body effect for a major disabling disease with substantial health burdens and economic costs .", "sentence_id": 11}
+{"abstract_id": "25199526", "label": "conclusions", "text": "Results of this study are expected to have important public health implications for the large and growing population with knee OA .", "sentence_id": 12}
+{"abstract_id": "24649784", "label": "background", "text": "General anesthesia ( GA ) is considered the gold standard for external dacryocystorhinostomy ( DCR ) surgery .", "sentence_id": 0}
+{"abstract_id": "24649784", "label": "background", "text": "There are few reports about laryngeal mask airway ( LMA ) use in DCR surgery .", "sentence_id": 1}
+{"abstract_id": "24649784", "label": "background", "text": "The aim of this study was to compare the use of endotracheal intubation ( ETT ) vs LMA for airway management during DCR surgery .", "sentence_id": 2}
+{"abstract_id": "24649784", "label": "methods", "text": "Ninety patients were randomized to two groups .", "sentence_id": 3}
+{"abstract_id": "24649784", "label": "methods", "text": "In the group C , ETT and in the group L , classic LMA was used to maintain and protect the airway during the procedure .", "sentence_id": 4}
+{"abstract_id": "24649784", "label": "methods", "text": "Hemodynamic data before , after intubation or LMA insertion and after skin incisions were recorded .", "sentence_id": 5}
+{"abstract_id": "24649784", "label": "methods", "text": "Coughing and straining at the end of anesthesia and postoperative nausea and vomiting ( PONV ) were recorded .", "sentence_id": 6}
+{"abstract_id": "24649784", "label": "results", "text": "In the group L , the mean arterial pressure and the heart rate after LMA insertion and after the skin incisions were significantly lower than the group C ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24649784", "label": "results", "text": "Furthermore , incidence of coughing , straining at the end of anesthesia and PONV was lower in the group L than the group C ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24649784", "label": "conclusions", "text": "LMA can be used in external DCR , to decrease the hemodynamic changes , to decrease coughing , straining at the end of anesthesia and the incidence of PONV .", "sentence_id": 9}
+{"abstract_id": "25996273", "label": "objective", "text": "Optimization of glycemic control is critical to reduce the number of diabetes mellitus-related complications , but long-term success is challenging .", "sentence_id": 0}
+{"abstract_id": "25996273", "label": "objective", "text": "Although vision loss is among the greatest fears of individuals with diabetes , comprehensive personalized diabetes education and risk assessments are not consistently used in ophthalmologic settings .", "sentence_id": 1}
+{"abstract_id": "25996273", "label": "objective", "text": "To determine whether the point-of-care measurement of hemoglobin A ( @c ) ( HbA ( @c ) ) and personalized diabetes risk assessments performed during retinal ophthalmologic visits improve glycemic control as assessed by HbA ( @c ) level .", "sentence_id": 2}
+{"abstract_id": "25996273", "label": "methods", "text": "Ophthalmologist office-based randomized , multicenter clinical trial in which investigators from @ sites were randomly assigned to provide either a study-prescribed augmented diabetes assessment and education or the usual care .", "sentence_id": 3}
+{"abstract_id": "25996273", "label": "methods", "text": "Adults with type @ or @ diabetes enrolled into @ cohorts : those with a more-frequent-than-annual follow-up ( @ control participants and @ intervention participants ) and those with an annual follow-up ( @ control participants and @ intervention participants ) .", "sentence_id": 4}
+{"abstract_id": "25996273", "label": "methods", "text": "Enrollment was from April @ through January @ .", "sentence_id": 5}
+{"abstract_id": "25996273", "label": "methods", "text": "Point-of-care measurements of HbA@c , blood pressure , and retinopathy severity ; an individualized estimate of the risk of retinopathy progression derived from the findings from ophthalmologic visits ; structured comparison and review of past and current clinical findings ; and structured education with immediate assessment and feedback regarding participant 's understanding .", "sentence_id": 6}
+{"abstract_id": "25996273", "label": "methods", "text": "These interventions were performed at enrollment and at routine ophthalmic follow-up visits scheduled at least @ weeks apart .", "sentence_id": 7}
+{"abstract_id": "25996273", "label": "methods", "text": "Mean change in HbA ( @c ) level from baseline to @-year follow-up .", "sentence_id": 8}
+{"abstract_id": "25996273", "label": "methods", "text": "Secondary outcomes included body mass index , blood pressure , and responses to diabetes self-management practices and attitudes surveys .", "sentence_id": 9}
+{"abstract_id": "25996273", "label": "results", "text": "In the cohort with more-frequent-than-annual follow-ups , the mean ( SD ) change in HbA ( @c ) level at @ year was -@ % ( @ % ) in the control group and -@ % ( @ % ) in the intervention group ( adjusted mean difference , -@ % -LSB- @ % CI , -@ % to @ % -RSB- ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25996273", "label": "results", "text": "In the cohort with annual follow-ups , the mean ( SD ) change in HbA ( @c ) level was @ % ( @ % ) in the control group and -@ % ( @ % ) in the intervention group ( mean difference , -@ % -LSB- @ % CI , -@ % to @ % -RSB- ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25996273", "label": "results", "text": "Results were similar for all secondary outcomes .", "sentence_id": 12}
+{"abstract_id": "25996273", "label": "conclusions", "text": "Long-term optimization of glycemic control is not achieved by a majority of individuals with diabetes .", "sentence_id": 13}
+{"abstract_id": "25996273", "label": "conclusions", "text": "The addition of personalized education and risk assessment during retinal ophthalmologic visits did not result in a reduction in HbA ( @c ) level compared with usual care over @ year .", "sentence_id": 14}
+{"abstract_id": "25996273", "label": "conclusions", "text": "These data suggest that optimizing glycemic control remains a substantive challenge requiring interventional paradigms other than those examined in our study .", "sentence_id": 15}
+{"abstract_id": "25227544", "label": "objective", "text": "To determine whether manual wheelchair configuration impacts how well a person who has acquired brain injury ( ABI ) related hemiparesis performs functional tasks from his or her wheelchair .", "sentence_id": 0}
+{"abstract_id": "25227544", "label": "methods", "text": "Multi-treatment cross-over design .", "sentence_id": 1}
+{"abstract_id": "25227544", "label": "methods", "text": "Inpatient rehabilitation hospital .", "sentence_id": 2}
+{"abstract_id": "25227544", "label": "methods", "text": "Nineteen patients with ABI resulting in hemiparesis undergoing inpatient rehabilitation ( average of @ days post-injury ( @ days ) ; age range , @-@ ; @ with mechanical brain injury , @ with cerebral vascular accident ) .", "sentence_id": 3}
+{"abstract_id": "25227544", "label": "methods", "text": "Participants in the study were placed in two different wheelchair configurations ( position one and position two ) and were randomized as to which position they were placed in first .", "sentence_id": 4}
+{"abstract_id": "25227544", "label": "methods", "text": "All outcome measures were taken twice on each individual within each wheelchair configuration during two consecutive days .", "sentence_id": 5}
+{"abstract_id": "25227544", "label": "methods", "text": "Timed Forward Wheeling ( TFW ) , Modified Functional Reach test ( MFR ) , Visual Analogue Scale for Comfort ( VAS ) , transfer score from the Functional Independence Measure ( FIM ) , measurement of popliteal fossa to front of cushion .", "sentence_id": 6}
+{"abstract_id": "25227544", "label": "results", "text": "The position two seating group 's TFW was significantly faster than the position one seating group at both time points .", "sentence_id": 7}
+{"abstract_id": "25227544", "label": "results", "text": "There were no significant differences in the MFR scores , VAS comfort scale scores , and FIM transfer score between the two groups .", "sentence_id": 8}
+{"abstract_id": "25227544", "label": "conclusions", "text": "A wheelchair configuration with no seat slope , solid backrest mounted at @ degree ( @ degrees ) seat to back angle , and use of a solid seat insert with a flat foam cushion ( position two ) results in greater efficiency in foot propulsion for individuals with ABI than a wheelchair configuration with one inch of seat slope , solid backrest mounted at @ degree ( @ degrees ) seat to back angle , and no solid seat insert with a gel/foam contoured cushion ( position @ ) .", "sentence_id": 9}
+{"abstract_id": "24793409", "label": "objective", "text": "In primary care the diagnosis of CHF and ECF accumulation is no triviality .", "sentence_id": 0}
+{"abstract_id": "24793409", "label": "objective", "text": "We aimed to predict plasma BNP , CHF and ECF accumulation with segmental impedance spectroscopy while using and extending the electrodes of the conventional electrocardiography .", "sentence_id": 1}
+{"abstract_id": "24793409", "label": "methods", "text": "Three combined multiple electrodes were added to the @ lead ECG for segmental impedance spectroscopy and for measuring the maximal rate of segmental fluid volume change with heart action at the thorax and the legs .", "sentence_id": 2}
+{"abstract_id": "24793409", "label": "methods", "text": "The obtained signals were analyzed by partial correlation analyses in comparison with plasma BNP , CHF classes , ejection fraction by echocardiography and cardiac index by double gas re-breathing .", "sentence_id": 3}
+{"abstract_id": "24793409", "label": "methods", "text": "@ subjects ( @ healthy volunteers , @ patients with CHF , NYHA classes II to IV and @ patients without CHF ) were investigated .", "sentence_id": 4}
+{"abstract_id": "24793409", "label": "results", "text": "The maximal rate of volume change with heart action at the thorax and at the legs , as well as the ECF/ICF ratio at the legs contribute equally and independently to the prediction of BNP and heart failure in an unknown test sample of @ patients ( multiple r = @ , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24793409", "label": "results", "text": "The ROC-curve for the predicted plasma BNP > @ pg/ml gave an AUC = @ .", "sentence_id": 6}
+{"abstract_id": "24793409", "label": "results", "text": "The absence or the presence of heart failure could be predicted correctly by a binomial logistic regression in @ and @ % of cases , respectively .", "sentence_id": 7}
+{"abstract_id": "24793409", "label": "conclusions", "text": "The methodology , which is based on inverse coupling of BNP release and of maximal blood acceleration and on sensitive detection of ECF overload , could enable the diagnosis of CHF with useful sensitivity and specificity while writing a routine-ECG .", "sentence_id": 8}
+{"abstract_id": "25081673", "label": "background", "text": "Although continuing education is necessary for practicing nurses , it is very difficult to organize traditional classes because of large numbers of nurses and working shifts .", "sentence_id": 0}
+{"abstract_id": "25081673", "label": "background", "text": "Considering the increasing development of mobile electronic learning , we carried out a study to compare effects of the traditional face to face method with mobile learning delivered as text messages by cell phone .", "sentence_id": 1}
+{"abstract_id": "25081673", "label": "methods", "text": "Sixty female nurses working in our hospital were randomly divided into class and short message service ( SMS ) groups .", "sentence_id": 2}
+{"abstract_id": "25081673", "label": "methods", "text": "Lessons concerning breast cancer screening were prepared as @ messages and sent in @ days for the SMS group , while the class group participated in a class held by a university lecturer of breast and cancer surgery .", "sentence_id": 3}
+{"abstract_id": "25081673", "label": "methods", "text": "Pre - and post-tests were undertaken for both groups at the same time ; a retention test also was performed one month later .", "sentence_id": 4}
+{"abstract_id": "25081673", "label": "methods", "text": "For statistical analysis , the paired T test and the independent sample T test were used with SPSS software version @ ; p < @ was considered significant .", "sentence_id": 5}
+{"abstract_id": "25081673", "label": "results", "text": "Mean age and mean work experience of participants in class and SMS groups was @ , @ , @ , and @ , respectively .", "sentence_id": 6}
+{"abstract_id": "25081673", "label": "results", "text": "There was a significant increase in mean score post-tests ( compared with pre-tests ) in both groups ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25081673", "label": "results", "text": "Although a better improvement in scores of retention tests was demonstrated in the SMS group , the mean subtraction value of the post - and pretests as well as retention - and pre-tests showed no significant difference between the @ groups ( p = @ and p = @ , respectively ) .", "sentence_id": 8}
+{"abstract_id": "25081673", "label": "conclusions", "text": "Our study shows that teaching via SMS may probably replace traditional face to face teaching for continuing education in working nurses .", "sentence_id": 9}
+{"abstract_id": "25081673", "label": "conclusions", "text": "Larger studies are suggested to confirm this .", "sentence_id": 10}
+{"abstract_id": "25751673", "label": "objective", "text": "Use of hypotonic intravenous fluids for maintenance requirements is associated with increased risk of hyponatremia that results in morbidity and mortality in children .", "sentence_id": 0}
+{"abstract_id": "25751673", "label": "objective", "text": "Clinical trial data comparing isotonic and hypotonic maintenance fluids in nonsurgical hospitalized pediatric patients outside intensive care units are lacking .", "sentence_id": 1}
+{"abstract_id": "25751673", "label": "objective", "text": "To compare isotonic ( sodium chloride , @ % , and dextrose , @ % ) with hypotonic ( sodium chloride , @ % , and dextrose , @ % ) intravenous maintenance fluids in a hospitalized general pediatric population .", "sentence_id": 2}
+{"abstract_id": "25751673", "label": "methods", "text": "In this double-blind randomized clinical trial , we recruited @ children admitted to a general pediatric unit of a tertiary care children 's hospital from March @ , @ , through August @ , @ ( age range , @ month to @ years ) , with normal baseline serum sodium levels who were anticipated to require intravenous maintenance fluids for @ hours or longer ( intent-to-treat analyses ) .", "sentence_id": 3}
+{"abstract_id": "25751673", "label": "methods", "text": "Children with diagnoses that required specific fluid tonicity and volumes were excluded .", "sentence_id": 4}
+{"abstract_id": "25751673", "label": "methods", "text": "Patients were randomized to receive isotonic or hypotonic intravenous fluid at maintenance rates for @ hours .", "sentence_id": 5}
+{"abstract_id": "25751673", "label": "methods", "text": "The primary outcome was mean serum sodium level at @ hours .", "sentence_id": 6}
+{"abstract_id": "25751673", "label": "methods", "text": "The secondary outcomes were mean sodium level at @ hours , hyponatremia and hypernatremia , weight gain , hypertension , and edema .", "sentence_id": 7}
+{"abstract_id": "25751673", "label": "methods", "text": "Confounding variables were included in multiple regression models .", "sentence_id": 8}
+{"abstract_id": "25751673", "label": "methods", "text": "Post hoc analyses included change from baseline sodium level at @ and @ hours and subgroup analysis of children with primary respiratory diagnosis .", "sentence_id": 9}
+{"abstract_id": "25751673", "label": "results", "text": "Of @ enrolled patients , @ received isotonic fluids and @ received hypotonic fluids .", "sentence_id": 10}
+{"abstract_id": "25751673", "label": "results", "text": "The mean ( SD ) sodium level at @ hours was @ ( @ ) mEq/L in the isotonic group and @ ( @ ) mEq/L in the hypotonic group ( @ % CI of the difference , -@ to @ mEq/L ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25751673", "label": "results", "text": "Two patients in the hypotonic group developed hyponatremia , @ in each group developed hypernatremia , @ in each group developed hypertension , and @ in the isotonic group developed edema .", "sentence_id": 12}
+{"abstract_id": "25751673", "label": "results", "text": "Mean ( SD ) change from baseline to @-hour sodium level was +@ ( @ ) vs -@ ( @ ) mEq/L , respectively ( absolute difference , @ mEq/L ; @ % CI of the difference , -@ to @ mEq/L ; P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25751673", "label": "conclusions", "text": "Our study results support the notion that isotonic maintenance fluid administration is safe in general pediatric patients and may result in fewer cases of hyponatremia .", "sentence_id": 14}
+{"abstract_id": "24842558", "label": "background", "text": "Individuals with heterozygous familial hypercholesterolemia ( heFH ) have higher levels of low-density lipoprotein cholesterol ( LDL-C ) and are predisposed to premature cardiovascular disease .", "sentence_id": 0}
+{"abstract_id": "24842558", "label": "background", "text": "Alirocumab is a fully-human , monoclonal antibody targeted to proprotein convertase subtilisin/kexin type @ currently in Phase @ development for the treatment of hypercholesterolemia .", "sentence_id": 1}
+{"abstract_id": "24842558", "label": "background", "text": "Described here are three ODYSSEY Phase @ trials , FH I ( NCT@ ) , FH II ( NCT@ ) and HIGH FH ( patients with heFH and LDL-C levels @mg/dL ) ( NCT@ ) , in which alirocumab is further evaluated in the heFH population .", "sentence_id": 2}
+{"abstract_id": "24842558", "label": "methods", "text": "Multicenter , multinational , randomized , double-blind , placebo-controlled studies have been designed to evaluate efficacy and safety of alirocumab in more than @ patients with heFH who are not adequately controlled with a maximally-tolerated stable daily dose of statin for @weeks prior to the screening visit , with or without other lipid-lowering therapy .", "sentence_id": 3}
+{"abstract_id": "24842558", "label": "methods", "text": "Patients are randomized ( @:@ ) to receive alirocumab or placebo via a @-mL subcutaneous auto-injection every @weeks ( Q@W ) for @weeks .", "sentence_id": 4}
+{"abstract_id": "24842558", "label": "methods", "text": "In studies FH I and II , if their Week @ LDL-C level is @mg/dL , patients will undergo a dose uptitration from @ to @mg alirocumab Q@W at Week @ .", "sentence_id": 5}
+{"abstract_id": "24842558", "label": "methods", "text": "In HIGH FH , patients will receive alirocumab @mg Q@W throughout the entire treatment period .", "sentence_id": 6}
+{"abstract_id": "24842558", "label": "methods", "text": "The primary efficacy endpoint in all three studies is the percent change in calculated LDL-C from baseline to Week @ .", "sentence_id": 7}
+{"abstract_id": "24842558", "label": "conclusions", "text": "The ODYSSEY FH studies are three Phase @ studies aiming to further evaluate the efficacy and long-term safety of alirocumab as an effective therapeutic option for patients with heFH .", "sentence_id": 8}
+{"abstract_id": "24988955", "label": "objective", "text": "To study the efficacy of the domestic recombinant interleukin-@ ( IL-@ ) in the complex treatment of encephalitis .", "sentence_id": 0}
+{"abstract_id": "24988955", "label": "methods", "text": "Forty patients , aged from @ months to @ years , were treated with the drug .", "sentence_id": 1}
+{"abstract_id": "24988955", "label": "methods", "text": "A comparison group involved @ patients who did not receive the drug .", "sentence_id": 2}
+{"abstract_id": "24988955", "label": "results", "text": "Recombinant IL-@ reduced ( p < @ ) the aggravation of symptoms to @ days , neurological deficit ( @ EDSS scores at discharge from the hospital ) , frequency of exacerbations ( from @ to @ % ) and frequency of cases with the development of multiple sclerosis during @ years ( from @ to @ % ) .", "sentence_id": 3}
+{"abstract_id": "24988955", "label": "results", "text": "Parameters of the drug efficacy were correlated with positive changes in immunological parameters after @-@ days of treatment .", "sentence_id": 4}
+{"abstract_id": "24988955", "label": "results", "text": "The study of multimodal evoked potentials demonstrated the positive effect of the drug on the central afferent conduction times .", "sentence_id": 5}
+{"abstract_id": "24988955", "label": "results", "text": "The follow-up MRI examination showed the decrease in the frequency of focal changes .", "sentence_id": 6}
+{"abstract_id": "24988955", "label": "conclusions", "text": "Recombinant IL-@ is recommended for treatment of children with encephalitis .", "sentence_id": 7}
+{"abstract_id": "24720558", "label": "background", "text": "Patients with obstructive sleep apnea ( OSA ) experience respiratory events with greater frequency and severity while in the supine sleeping position .", "sentence_id": 0}
+{"abstract_id": "24720558", "label": "background", "text": "Postural modification devices ( PMDs ) prevent supine sleep , although there is a paucity of guidance to help clinicians decide when to use PMDs for their patients .", "sentence_id": 1}
+{"abstract_id": "24720558", "label": "background", "text": "In order for PMDs to treat OSA effectively , patients must experience respiratory events in the supine sleeping position consistently from night to night and must have a low nonsupine apnea and hypopnea index ( AHINS ) .", "sentence_id": 2}
+{"abstract_id": "24720558", "label": "objective", "text": "To document the repeatability of traditionally defined supine predominant OSA on consecutive polysomnography , to determine whether the consistency of the supine-predominant phenotype can be improved by altering the definition of it , and to determine whether a low AHINS is repeatable from night to night .", "sentence_id": 3}
+{"abstract_id": "24720558", "label": "methods", "text": "We recruited @ patients for polysomnography on two separate nights .", "sentence_id": 4}
+{"abstract_id": "24720558", "label": "methods", "text": "Patients were classified as having supine OSA on each night on the basis of traditional and novel definitions , and the classification systems used were compared on the basis of agreement from night to night .", "sentence_id": 5}
+{"abstract_id": "24720558", "label": "results", "text": "The definition of supine OSA with the highest level of agreement from night to night incorporates a supine AHI ( AHIS ) to AHINS ratio @:@ .", "sentence_id": 6}
+{"abstract_id": "24720558", "label": "results", "text": "In addition , agreement exists for males , but there is poor agreement for female patients , regardless of the definition applied .", "sentence_id": 7}
+{"abstract_id": "24720558", "label": "results", "text": "An AHINS < @ events/hour is highly repeatable from night to night .", "sentence_id": 8}
+{"abstract_id": "24720558", "label": "conclusions", "text": "Males with an AHIS : AHINS ratio @:@ and an AHINS < @ events/hour represent a consistent supine-predominant OSA phenotype from night to night .", "sentence_id": 9}
+{"abstract_id": "24720558", "label": "conclusions", "text": "This patient group is likely to benefit from treatment with PMD .", "sentence_id": 10}
+{"abstract_id": "25175097", "label": "background", "text": "The management of depression in patients with poor prognosis cancers , such as lung cancer , creates specific challenges .", "sentence_id": 0}
+{"abstract_id": "25175097", "label": "background", "text": "We aimed to assess the efficacy of an integrated treatment programme for major depression in patients with lung cancer compared with usual care .", "sentence_id": 1}
+{"abstract_id": "25175097", "label": "methods", "text": "Symptom Management Research Trials ( SMaRT ) Oncology-@ is a parallel-group , multicentre , randomised controlled trial .", "sentence_id": 2}
+{"abstract_id": "25175097", "label": "methods", "text": "We enrolled patients with lung cancer and major depression from three cancer centres and their associated clinics in Scotland , UK .", "sentence_id": 3}
+{"abstract_id": "25175097", "label": "methods", "text": "Participants were randomly assigned in a @:@ ratio to the depression care for people with lung cancer treatment programme or usual care by a database software algorithm that used stratification ( by trial centre ) and minimisation ( by age , sex , and cancer type ) with allocation concealment .", "sentence_id": 4}
+{"abstract_id": "25175097", "label": "methods", "text": "Depression care for people with lung cancer is a manualised , multicomponent collaborative care treatment that is systematically delivered by a team of cancer nurses and psychiatrists in collaboration with primary care physicians .", "sentence_id": 5}
+{"abstract_id": "25175097", "label": "methods", "text": "Usual care is provided by primary care physicians .", "sentence_id": 6}
+{"abstract_id": "25175097", "label": "methods", "text": "The primary outcome was depression severity ( on the Symptom Checklist Depression Scale -LSB- SCL-@ -RSB- , range @-@ ) averaged over the patient 's time in the trial ( up to a maximum of @ weeks ) .", "sentence_id": 7}
+{"abstract_id": "25175097", "label": "methods", "text": "Trial statisticians and data collection staff were masked to treatment allocation , but patients and clinicians could not be masked to the allocations .", "sentence_id": 8}
+{"abstract_id": "25175097", "label": "methods", "text": "Analyses were by intention to treat .", "sentence_id": 9}
+{"abstract_id": "25175097", "label": "methods", "text": "This trial is registered with Current Controlled Trials , number ISRCTN@ .", "sentence_id": 10}
+{"abstract_id": "25175097", "label": "results", "text": "@ participants were recruited between Jan @ , @ , and Sept @ , @ ; @ were randomly allocated to depression care for people with lung cancer and @ to usual care .", "sentence_id": 11}
+{"abstract_id": "25175097", "label": "results", "text": "@ ( @ % ) of @ patients had died by @ weeks , all of which were cancer-related deaths .", "sentence_id": 12}
+{"abstract_id": "25175097", "label": "results", "text": "No intervention-related serious adverse events occurred .", "sentence_id": 13}
+{"abstract_id": "25175097", "label": "results", "text": "@ ( @ % ) of @ patients provided outcome data ( @ in the depression care for people with lung cancer group and @ in the usual care group ) and were included in the intention-to-treat primary analysis .", "sentence_id": 14}
+{"abstract_id": "25175097", "label": "results", "text": "Average depression severity was significantly lower in patients allocated to depression care for people with lung cancer ( mean score on the SCL-@ @ -LSB- SD @ -RSB- ) than in those allocated to usual care ( mean score @ -LSB- SD @ -RSB- ) ; difference -@ ( @ % CI -@ to -@ ) ; standardised mean difference -@ ( @ % CI -@ to -@ ) .", "sentence_id": 15}
+{"abstract_id": "25175097", "label": "results", "text": "Self-rated depression improvement , anxiety , quality of life , role functioning , perceived quality of care , and proportion of patients achieving a @-week treatment response were also significantly better in the depression care for people with lung cancer group than in the usual care group .", "sentence_id": 16}
+{"abstract_id": "25175097", "label": "conclusions", "text": "Our findings suggest that major depression can be treated effectively in patients with a poor prognosis cancer ; integrated depression care for people with lung cancer was substantially more efficacious than was usual care .", "sentence_id": 17}
+{"abstract_id": "25175097", "label": "conclusions", "text": "Larger trials are now needed to estimate the effectiveness and cost-effectiveness of this care programme in this patient population , and further adaptation of the treatment will be necessary to address the unmet needs of patients with major depression and even shorter life expectancy .", "sentence_id": 18}
+{"abstract_id": "24986094", "label": "objective", "text": "Glycopyrronium ( NVA@ ) , a once-daily long-acting muscarinic antagonist , has recently been approved for the treatment of patients with chronic obstructive pulmonary disease ( COPD ) .", "sentence_id": 0}
+{"abstract_id": "24986094", "label": "objective", "text": "This study evaluated the effect of glycopyrronium on the QT interval and other cardiac parameters in healthy subjects .", "sentence_id": 1}
+{"abstract_id": "24986094", "label": "methods", "text": "This randomized , partially blinded , single-dose , placebo - and positive - ( moxifloxacin ) controlled , three-way cross-over study investigated the effect of a single inhaled supra-therapeutic dose ( @-fold clinical dose in COPD patients ) of @ g glycopyrronium on the Fridericia-corrected QT interval ( QTcF ; primary objective ) , Bazettcorrected QT interval ( QTcB ) , heart rate , blood pressure , pharmacokinetics ( PK ) , safety , and tolerability .", "sentence_id": 2}
+{"abstract_id": "24986094", "label": "results", "text": "A total of @ healthy male ( n = @ ) and female ( n = @ ) subjects , aged between @ and @ years , were randomized .", "sentence_id": 3}
+{"abstract_id": "24986094", "label": "results", "text": "Glycopyrronium did not cause significant QTcF prolongation compared to placebo .", "sentence_id": 4}
+{"abstract_id": "24986094", "label": "results", "text": "The largest time-matched mean difference to placebo was @ ms at @ minutes , with the upper limit of the two-sided @ % confidence interval ( CI ) being @ ms , excluding a relevant QT effect as defined by the ICH E@ guideline .", "sentence_id": 5}
+{"abstract_id": "24986094", "label": "results", "text": "Glycopyrronium had a slight bradycardic effect with a mean change of -@ ( @ % CI : -@ , -@ ) beats per minutes ( bpm ) and a maximum of -@ ( @ % CI : -@ , -@ ) bpm at @ hours post-inhalation .", "sentence_id": 6}
+{"abstract_id": "24986094", "label": "results", "text": "No clinically relevant effects were seen on QTcB , other electrocardiogram ( ECG ) intervals , or blood pressure .", "sentence_id": 7}
+{"abstract_id": "24986094", "label": "results", "text": "Maximum plasma concentration ( Cmax ) of glycopyrronium was achieved shortly after inhalation ( median tmax = @ minutes ) .", "sentence_id": 8}
+{"abstract_id": "24986094", "label": "results", "text": "All the treatments were well tolerated with no serious adverse events .", "sentence_id": 9}
+{"abstract_id": "24986094", "label": "conclusions", "text": "A supra-therapeutic dose of glycopyrronium had a favorable cardiovascular safety profile with no clinically relevant effect on QT interval .", "sentence_id": 10}
+{"abstract_id": "24388868", "label": "background", "text": "If asthma patients fail to achieve symptom control using a medium dose of inhaled corticosteroid ( ICS ) alone , adding a long-acting @ agonist ( LABA ) is the preferred treatment .", "sentence_id": 0}
+{"abstract_id": "24388868", "label": "background", "text": "We aimed to compare the effect of two widely available ICS/LABA combinations in these patients in real-life conditions : budesonide/formoterol ( BUD/FM ; Symbicort ( ) ) for maintenance and reliever therapy ( SMART ) and a fixed dose of fluticasone propionate/salmeterol ( FP/SM ) .", "sentence_id": 1}
+{"abstract_id": "24388868", "label": "methods", "text": "Inadequately controlled asthma patients treated with a medium dose of ICS alone , with an Asthma Control Questionnaire ( ACQ ) score > @ and using a short-acting @-agonist ( SABA ) @-@ occasions/week , were enrolled .", "sentence_id": 2}
+{"abstract_id": "24388868", "label": "methods", "text": "Patients were randomized into two groups and treated with two inhalation twice-daily BUD/FM @/@ @ g plus as-needed BUD/FM ( SMART group , n = @ ) or one inhalation twice-daily FP/SM @/@g plus as-needed procaterol ( FP/SM group , n = @ ) for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24388868", "label": "results", "text": "Both groups showed significant improvement in airway inflammation , pulmonary functions and symptoms from baseline .", "sentence_id": 4}
+{"abstract_id": "24388868", "label": "results", "text": "The SMART group showed significant improvement in the fraction of nitric oxide , ACQ score , rescue medication use and small airway parameter R@-R@ measured by impulse oscillometry compared with the FP/SM group .", "sentence_id": 5}
+{"abstract_id": "24388868", "label": "conclusions", "text": "For stepping up treatment from ICS alone to an ICS/LABA combination , SMART is preferable for controlling asthma symptoms by suppressing airway inflammation and improving small airway impairment compared with a fixed dose of FP/SM .", "sentence_id": 6}
+{"abstract_id": "24388868", "label": "conclusions", "text": "It may be achieved by the property of BUD/FM itself and as-needed use , but the degree of each contribution must be investigated further .", "sentence_id": 7}
+{"abstract_id": "24268387", "label": "objective", "text": "This study assessed the effects of systemic omega-@ on the treatment of recurrent aphthous stomatitis and on the improvement of quality of life .", "sentence_id": 0}
+{"abstract_id": "24268387", "label": "methods", "text": "Fifty participants were randomly assigned to receive either omega-@ ( @ g , @ times daily ) or placebo for @ months .", "sentence_id": 1}
+{"abstract_id": "24268387", "label": "methods", "text": "Assessment of outcome measures including monthly number of new ulcers , average duration of ulcer episodes , and pain level of ulcers was carried out at baseline and monthly for @ months .", "sentence_id": 2}
+{"abstract_id": "24268387", "label": "methods", "text": "Analysis of potential impact on quality of life using the Oral Health Impact Profile @ was carried out at baseline and @ months .", "sentence_id": 3}
+{"abstract_id": "24268387", "label": "results", "text": "Daily omega-@ treatment achieved a significant reduction in number of ulcers , duration of ulcers , and level of pain by @ months that persisted for @ months .", "sentence_id": 4}
+{"abstract_id": "24268387", "label": "results", "text": "Mean score on Oral Health Impact Profile @ also significantly improved by @ months .", "sentence_id": 5}
+{"abstract_id": "24268387", "label": "conclusions", "text": "A daily omega-@ regimen shows promise as therapy for treatment and management of patients with recurrent aphthous stomatitis .", "sentence_id": 6}
+{"abstract_id": "25361981", "label": "background", "text": "We and others have recently shown that tumor characteristics are altered throughout tumor progression .", "sentence_id": 0}
+{"abstract_id": "25361981", "label": "background", "text": "These findings emphasize the need for re-examination of tumor characteristics at relapse and have led to recommendations from ESMO and the Swedish Breast Cancer group .", "sentence_id": 1}
+{"abstract_id": "25361981", "label": "background", "text": "Here , we aim to determine whether tumor characteristics and molecular subtypes in breast cancer metastases confer clinically relevant prognostic information for patients .", "sentence_id": 2}
+{"abstract_id": "25361981", "label": "methods", "text": "The translational aspect of the Swedish multicenter randomized trial called TEX included @ patients with at least one biopsy from a morphologically confirmed locoregional or distant breast cancer metastasis diagnosed from December @ until June @ .", "sentence_id": 3}
+{"abstract_id": "25361981", "label": "methods", "text": "All patients had detailed clinical information , complete follow-up , and metastasis gene expression information ( Affymetrix array GPL@ ) .", "sentence_id": 4}
+{"abstract_id": "25361981", "label": "methods", "text": "We assessed the previously published gene expression modules describing biological processes -LSB- proliferation , apoptosis , human epidermal receptor @ ( HER@ ) and estrogen ( ER ) signaling , tumor invasion , immune response , and angiogenesis -RSB- and pathways ( Ras , MAPK , PTEN , AKT-MTOR , PI@KCA , IGF@ , Src , Myc , E@F@ , and - catenin ) and the intrinsic subtypes ( PAM@ ) .", "sentence_id": 5}
+{"abstract_id": "25361981", "label": "methods", "text": "Furthermore , by contrasting genes expressed in the metastases in relation to survival , we derived a poor metastasis survival signature .", "sentence_id": 6}
+{"abstract_id": "25361981", "label": "results", "text": "A significant reduction in post-relapse breast cancer-specific survival was associated with low-ER receptor signaling and apoptosis gene module scores , and high AKT-MTOR , Ras , and - catenin module scores .", "sentence_id": 7}
+{"abstract_id": "25361981", "label": "results", "text": "Similarly , intrinsic subtyping of the metastases provided statistically significant post-relapse survival information with the worst survival outcome in the basal-like -LSB- hazard ratio ( HR ) @ ; @ % confidence interval ( CI ) @-@ @ -RSB- and HER@-enriched ( HR @ ; @ % CI @-@ @ ) subtypes compared with the luminal A subtype .", "sentence_id": 8}
+{"abstract_id": "25361981", "label": "results", "text": "Overall , @ % of the metastases were basal-like , @ % HER@-enriched , @ % luminal A , @ % luminal B , and @ % normal-like .", "sentence_id": 9}
+{"abstract_id": "25361981", "label": "conclusions", "text": "We show that tumor characteristics and molecular subtypes of breast cancer metastases significantly influence post-relapse patient survival , emphasizing that molecular investigations at relapse provide prognostic and clinically relevant information .", "sentence_id": 10}
+{"abstract_id": "25361981", "label": "conclusions", "text": "CLINICALTRIALS.GOV : This is the translational part of the Swedish multicenter and randomized trial TEX , clinicaltrials.gov identifier nct@ ( http://www.clinicaltrials.gov/ct@/show/nct@ ) .", "sentence_id": 11}
+{"abstract_id": "25240548", "label": "objective", "text": "This study aimed to determine whether remote ischemic conditioning ( RIC ) initiated prior to primary percutaneous coronary intervention ( PPCI ) could reduce myocardial infarct ( MI ) size in patients presenting with ST-segment elevation myocardial infarction .", "sentence_id": 0}
+{"abstract_id": "25240548", "label": "background", "text": "RIC , using transient limb ischemia and reperfusion , can protect the heart against acute ischemia-reperfusion injury .", "sentence_id": 1}
+{"abstract_id": "25240548", "label": "background", "text": "Whether RIC can reduce MI size , assessed by cardiac magnetic resonance ( CMR ) , is unknown .", "sentence_id": 2}
+{"abstract_id": "25240548", "label": "methods", "text": "We randomly assigned @ ST-segment elevation myocardial infarction patients with TIMI ( Thrombolysis In Myocardial Infarction ) flow grade @ to receive RIC ( four @-min cycles of upper arm cuff inflation/deflation ) or control ( uninflated cuff placed on upper arm for @ min ) protocols prior to PPCI .", "sentence_id": 3}
+{"abstract_id": "25240548", "label": "methods", "text": "The primary study endpoint was MI size , measured by CMR in @ subjects on days @ to @ after admission .", "sentence_id": 4}
+{"abstract_id": "25240548", "label": "results", "text": "RIC reduced MI size by @ % , when compared with the MI size of control subjects ( @ @ % -LSB- n = @ -RSB- vs. @ @ % -LSB- n = @ -RSB- ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25240548", "label": "results", "text": "At @ h , high-sensitivity troponin T was lower with RIC ( @,@ @ ng/l -LSB- n = @ -RSB- vs. @,@ @ ng/l -LSB- n = @ -RSB- ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25240548", "label": "results", "text": "RIC also reduced the extent of myocardial edema measured by T@-mapping CMR ( @ @ % vs. @ @ % ; p = @ ) and lowered mean T@ values ( @ @ ms vs. @ @ ms ; p = @ ) , precluding the use of CMR edema imaging to correctly estimate the area at risk .", "sentence_id": 7}
+{"abstract_id": "25240548", "label": "results", "text": "Using CMR-independent coronary angiography jeopardy scores to estimate the area at risk , RIC , when compared with the control protocol , was found to significantly improve the myocardial salvage index ( @ @ vs. @ @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25240548", "label": "conclusions", "text": "This randomized study demonstrated that in ST-segment elevation myocardial infarction patients treated by PPCI , RIC , initiated prior to PPCI , reduced MI size , increased myocardial salvage , and reduced myocardial edema .", "sentence_id": 9}
+{"abstract_id": "25180869", "label": "objective", "text": "To perform an analysis and comparative study of the clinical data for patients with cirrhosis and type @ hepatorenal syndrome ( HRS ) who received treatment with terlipressin using high-or low-dose regimens .", "sentence_id": 0}
+{"abstract_id": "25180869", "label": "methods", "text": "A total of @ patients with cirrhosis and type @ HRS who presented for treatment to the Wuhan Medical Treatment Center and Taizhou Central Hospital between March @ and October @ were enrolled in the study .", "sentence_id": 1}
+{"abstract_id": "25180869", "label": "methods", "text": "The patients were randomly assigned to the terlipressin treatment groups for receipt of the high-dose regimen ( @ mg/@ -@ h ; n = @ ) or low-dose regimen ( @ mg/@ h ; n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25180869", "label": "methods", "text": "All patients were assessed for @-hour urine volume , serum blood urea nitrogen ( BUN ) and creatinine ( Cr ) levels , therapeutic effect and prognosis , and adverse reactions .", "sentence_id": 3}
+{"abstract_id": "25180869", "label": "methods", "text": "Measurements were made before and after the treatment , and on post-treatment days @ , @ and @ .", "sentence_id": 4}
+{"abstract_id": "25180869", "label": "methods", "text": "Inter-group differences were assessed by statistical analyses .", "sentence_id": 5}
+{"abstract_id": "25180869", "label": "results", "text": "The high-dose group showed an increase in @-hour urine volumes from post-treatment day @ ( @ @ ml ) to day @ ( @ @ ml ) , and the volumes on both days were significantly better than those of the low-dose group ( day @:@ @ ml and day @:@ @ ml , t = @ , @ , P = @ , @ ) .", "sentence_id": 6}
+{"abstract_id": "25180869", "label": "results", "text": "The high-dose group also showed a significantly better decreases in serum BUN levels ( @ @ to @ @ mmol/L vs.low-dose group : @ @ to @ @ mmol/L , t = @ , @ , P = @ , @ ) and in serum Cr values ( @ @ to @ @ vs.low-dose group : @ @ to @ @ , t = @ , @ , P = @ , @ ) .", "sentence_id": 7}
+{"abstract_id": "25180869", "label": "results", "text": "On post-treatment day @ the @-hour urine volume of patients in the high-dose group decreased ( to @ + / -@ ml ) , but the difference from that of the low-dose group was not significant ( vs. @ @ ml , t = @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25180869", "label": "results", "text": "The serum BUN level increased in the high-dose group ( to @ @ mmol/L ) , which was statistically different from that in the low-dose group ( vs @ @ mmol/L , t = @ , P = @ ) ; the same trend was seen for the serum Cr value ( @ @ mumol/L vs. @ @ mumol/L , t = @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25180869", "label": "results", "text": "No statistically significant differences were observed for the groups in regard to significant efficiency , efficiency or @-week survival rate ( x@ = @ , @ , @ , P = @ , @ , @ respectively ) , but the total efficiency was significantly different between the two groups ( x = @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25180869", "label": "results", "text": "In addition , no serious adverse reactions ( including precordial pain , myocardial infarction or intestinal necrosis ) were observed in either group .", "sentence_id": 11}
+{"abstract_id": "25180869", "label": "conclusions", "text": "Terlipressin therapy at both high and low dosages can lead to significant beneficial effects within as little as @ days after the treatment ; however , the high-dose appears to produce a better lasting efficacy ( at day @ after the treatment ) .", "sentence_id": 12}
+{"abstract_id": "25180869", "label": "conclusions", "text": "The difference in doses does not appear to markedly affect significant efficiency , efficiency , nor the @-week survival rate .", "sentence_id": 13}
+{"abstract_id": "25560448", "label": "objective", "text": "To evaluate the effect of a clinic-based screening and referral system ( Well Child Care , Evaluation , Community Resources , Advocacy , Referral , Education -LSB- WE CARE -RSB- ) on families ' receipt of community-based resources for unmet basic needs .", "sentence_id": 0}
+{"abstract_id": "25560448", "label": "methods", "text": "We conducted a cluster randomized controlled trial at @ urban community health centers , recruiting mothers of healthy infants .", "sentence_id": 1}
+{"abstract_id": "25560448", "label": "methods", "text": "In the @ WE CARE clinics , mothers completed a self-report screening instrument that assessed needs for child care , education , employment , food security , household heat , and housing .", "sentence_id": 2}
+{"abstract_id": "25560448", "label": "methods", "text": "Providers made referrals for families ; staff provided requisite applications and telephoned referred mothers within @ month .", "sentence_id": 3}
+{"abstract_id": "25560448", "label": "methods", "text": "Families at the @ control community health centers received the usual care .", "sentence_id": 4}
+{"abstract_id": "25560448", "label": "methods", "text": "We analyzed the results with generalized mixed-effect models .", "sentence_id": 5}
+{"abstract_id": "25560448", "label": "results", "text": "Three hundred thirty-six mothers were enrolled in the study ( @ per arm ) .", "sentence_id": 6}
+{"abstract_id": "25560448", "label": "results", "text": "The majority of families had household incomes < $ @,@ ( @ % ) , and @ % had @ unmet basic needs .", "sentence_id": 7}
+{"abstract_id": "25560448", "label": "results", "text": "More WE CARE mothers received @ referral at the index visit ( @ % vs @ % ; adjusted odds ratio -LSB- aOR -RSB- = @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25560448", "label": "results", "text": "At the @-month visit , more WE CARE mothers had enrolled in a new community resource ( @ % vs @ % ; aOR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 9}
+{"abstract_id": "25560448", "label": "results", "text": "WE CARE mothers had greater odds of being employed ( aOR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25560448", "label": "results", "text": "WE CARE children had greater odds of being in child care ( aOR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "25560448", "label": "results", "text": "WE CARE families had greater odds of receiving fuel assistance ( aOR = @ ; @ % CI , @-@ @ ) and lower odds of being in a homeless shelter ( aOR = @ ; @ % CI , @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "25560448", "label": "conclusions", "text": "Systematically screening and referring for social determinants during well child care can lead to the receipt of more community resources for families .", "sentence_id": 13}
+{"abstract_id": "24591266", "label": "background", "text": "Inadequate surgical field visualization due to intraoperative bleeding during endoscopic sinus surgery ( ESS ) can cause major complications .", "sentence_id": 0}
+{"abstract_id": "24591266", "label": "background", "text": "The aim of this prospective study was to compare the effect of preoperative administration of clonidine and melatonin on the quality of the surgical field visualization and selected aspects of presurgical premedication .", "sentence_id": 1}
+{"abstract_id": "24591266", "label": "methods", "text": "Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication .", "sentence_id": 2}
+{"abstract_id": "24591266", "label": "methods", "text": "During the operation , the quality of the surgical field was assessed and graded using the scale proposed by Boezaart .", "sentence_id": 3}
+{"abstract_id": "24591266", "label": "methods", "text": "The evaluations were done at @ , @ , and @ minutes after incision .", "sentence_id": 4}
+{"abstract_id": "24591266", "label": "methods", "text": "The effect of this premedication choice on the intraoperative and postoperative hemodynamic profile was examined in each group .", "sentence_id": 5}
+{"abstract_id": "24591266", "label": "methods", "text": "Anxiolytic effects of both premedication agents were assessed using the visual analogue scale for anxiety ( VAS-A ) .", "sentence_id": 6}
+{"abstract_id": "24591266", "label": "methods", "text": "Propofol dose and induction time ( the time for bispectral index -LSB- BIS -RSB- to reach @ ) , anesthesia and surgical procedures time , and recovery time ( the time for BIS to reach @ ) were assessed in both groups as well .", "sentence_id": 7}
+{"abstract_id": "24591266", "label": "results", "text": "The quality of the surgical field was consistently better in @ of @ time points in the clonidine group .", "sentence_id": 8}
+{"abstract_id": "24591266", "label": "results", "text": "Perioperative mean arterial pressure and intraoperative heart rate had a more favorable profile in patients premedicated with clonidine .", "sentence_id": 9}
+{"abstract_id": "24591266", "label": "results", "text": "There were no differences in other measured parameters between groups .", "sentence_id": 10}
+{"abstract_id": "24591266", "label": "conclusions", "text": "Premedication with clonidine before ESS provides better quality of surgical field and more favorable hemodynamic profile as compared to melatonin .", "sentence_id": 11}
+{"abstract_id": "24309022", "label": "objective", "text": "To evaluate the effect of oral Lactobacillus reuteri ( L reuteri ) first on the incidence and severity of Necrotising enterocolitis ( NEC ) and second on sepsis .", "sentence_id": 0}
+{"abstract_id": "24309022", "label": "methods", "text": "Prospective randomised controlled study .", "sentence_id": 1}
+{"abstract_id": "24309022", "label": "methods", "text": "Tertiary neonatal intensive care unit .", "sentence_id": 2}
+{"abstract_id": "24309022", "label": "methods", "text": "Preterm infants with a gestational age of @ weeks and a birth weight of @ g were included ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24309022", "label": "methods", "text": "Infants in the first group were given @ million CFU/day ( @ drops ) of lyophilised L reuteri ( DSM @ ) mixed in breast milk or formula , starting from first feeding until discharge .", "sentence_id": 4}
+{"abstract_id": "24309022", "label": "methods", "text": "Participants in the control group were given a placebo .", "sentence_id": 5}
+{"abstract_id": "24309022", "label": "methods", "text": "To determine and compare the frequency of NEC and/or death after @ days , frequency of proven sepsis , rates of feeding intolerance and duration of hospital stay .", "sentence_id": 6}
+{"abstract_id": "24309022", "label": "results", "text": "There was no statistically significant difference between groups in terms of frequency of NEC stage @ ( @ % vs @ % ; p = @ ) or overall NEC or mortality rates ( @ % vs @ % ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24309022", "label": "results", "text": "Frequency of proven sepsis was significantly lower in the probiotic group compared to the control group ( @ % vs @ % ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24309022", "label": "results", "text": "A significant difference was also observed with regard to rates of feeding intolerance ( @ % vs @ % ; p = @ ) and duration of hospital stay ( @ ( @-@ ) vs @ ( @-@ ) days ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24309022", "label": "conclusions", "text": "Our results show that oral L reuteri does not seem to affect the overall rates of NEC and/or death in preterm infants followed up in the neonatal intensive care unit , and significant reductions were observed in the frequency of proven sepsis , rates of feeding intolerance and duration of hospital stay .", "sentence_id": 10}
+{"abstract_id": "25288513", "label": "background", "text": "Current research suggests that glucose facilitates performance on cognitive tasks which possess an episodic memory component and a relatively high level of cognitive demand .", "sentence_id": 0}
+{"abstract_id": "25288513", "label": "background", "text": "However , the extent to which this glucose facilitation effect is uniform across the lifespan is uncertain .", "sentence_id": 1}
+{"abstract_id": "25288513", "label": "methods", "text": "This study was a repeated measures , randomised , placebo-controlled , cross-over trial designed to assess the cognitive effects of glucose in younger and older adults under single and dual task conditions .", "sentence_id": 2}
+{"abstract_id": "25288513", "label": "methods", "text": "Participants were @ healthy younger ( average age @ years ) and @ healthy older adults ( average age @ years ) .", "sentence_id": 3}
+{"abstract_id": "25288513", "label": "methods", "text": "They completed a recognition memory task after consuming drinks containing @ g glucose and a placebo drink , both in the presence and absence of a secondary tracking task .", "sentence_id": 4}
+{"abstract_id": "25288513", "label": "conclusions", "text": "Glucose enhanced recognition memory response time and tracking precision during the secondary task , in older adults only .", "sentence_id": 5}
+{"abstract_id": "25288513", "label": "conclusions", "text": "These findings do not support preferential targeting of hippocampal function by glucose , rather they suggest that glucose administration differentially increases the availability of attentional resources in older individuals .", "sentence_id": 6}
+{"abstract_id": "25117033", "label": "background", "text": "Hip and knee osteoarthritis are important causes of pain and disability among older people .", "sentence_id": 0}
+{"abstract_id": "25117033", "label": "background", "text": "Education and strength training can alleviate symptoms and avoid functional deterioration .", "sentence_id": 1}
+{"abstract_id": "25117033", "label": "objective", "text": "To assess muscle strength , fall risk and quality of life of older people with osteoarthritis and the effects of physiotherapy education and strength training on these variables .", "sentence_id": 2}
+{"abstract_id": "25117033", "label": "methods", "text": "Thirty participants aged @ @ years ( @ % women ) were randomly assigned to receive physiotherapy ( Controls ) , physiotherapy plus education ( Group @ ) and physiotherapy plus strength training ( group @ ) .", "sentence_id": 3}
+{"abstract_id": "25117033", "label": "methods", "text": "At baseline and after @ weeks of intervention , patients were evaluated with the Senior Fitness Test , Timed Up and Go and Quality of Life score short form ( SF-@ ) .", "sentence_id": 4}
+{"abstract_id": "25117033", "label": "results", "text": "During the intervention period , Senior Fitness Test and Timed Up and Go scores improved in all groups and SF-@ did not change .", "sentence_id": 5}
+{"abstract_id": "25117033", "label": "results", "text": "The improvement in Senior Fitness Test and Timed Up and Go was more marked in Groups @ and @ than in the control group .", "sentence_id": 6}
+{"abstract_id": "25117033", "label": "conclusions", "text": "Education and strength training improve functional tests among older people with osteoarthritis .", "sentence_id": 7}
+{"abstract_id": "25782685", "label": "objective", "text": "Concurrent chemoradiotherapy ( CRT ) is the standard treatment for advanced head and neck squamous cell carcinoma .", "sentence_id": 0}
+{"abstract_id": "25782685", "label": "objective", "text": "In this phase II randomized study , the efficacy and toxicity of docetaxel , cisplatin and @-fluorouracil induction chemotherapy ( ICT ) followed by concurrent CRT was compared with those after standard CRT alone in patients with locally advanced , unresectable head and neck cancer .", "sentence_id": 1}
+{"abstract_id": "25782685", "label": "methods", "text": "Between January @ and June @ , @ patients with advanced ( stage III or IV ) unresectable squamous cell carcinoma of the head and neck ( oral cavity , oropharynx , hypopharynx , and larynx ) were randomly assigned to two groups : one receiving two cycles of docetaxel , cisplatin , and @-fluorouracil ICT followed by CRT with three cycles of cisplatin and one treated by CRT alone .", "sentence_id": 2}
+{"abstract_id": "25782685", "label": "methods", "text": "Response rate , local tumor control ( LTC ) , locoregional tumor control ( LRTC ) , overall survival ( OS ) , progression-free survival ( PFS ) , and toxicity results were assessed .", "sentence_id": 3}
+{"abstract_id": "25782685", "label": "results", "text": "Three patients from the ICT + CRT group did not appear at the first treatment , so a total of @ patients were evaluated in the study ( @ ICT + CRT group and @ CRT group ) .", "sentence_id": 4}
+{"abstract_id": "25782685", "label": "results", "text": "Three patients died of febrile neutropenia after ICT .", "sentence_id": 5}
+{"abstract_id": "25782685", "label": "results", "text": "The median follow-up time for surviving patients was @ months ( range @-@ months ) .", "sentence_id": 6}
+{"abstract_id": "25782685", "label": "results", "text": "The rate of radiologic complete response was @ % following ICT + CRT , whereas @ % after CRT alone .", "sentence_id": 7}
+{"abstract_id": "25782685", "label": "results", "text": "There were no significant differences in the @-year rates of LTC ( @ vs. @ % ) , LRTC ( @ vs. @ % ) , OS ( @ vs. @ % ) , and PFS ( @ vs. @ % ) in the ICT + CRT group and in the CRT group , respectively .", "sentence_id": 8}
+{"abstract_id": "25782685", "label": "results", "text": "The rate of grade @-@ neutropenia was significantly higher in the ICT + CRT group than in the CRT group ( @ and @ % ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25782685", "label": "results", "text": "Late toxicity ( grade @ or @ xerostomia ) developed in @ and @ % in the ICT + CRT and CRT groups , respectively .", "sentence_id": 10}
+{"abstract_id": "25782685", "label": "conclusions", "text": "The addition of ICT to CRT did not show any advantage in our phase II trial , while the incidence of adverse events increased .", "sentence_id": 11}
+{"abstract_id": "25782685", "label": "conclusions", "text": "The three deaths as a consequence of ICT call attention to the importance of adequate patient selection if ICT is considered .", "sentence_id": 12}
+{"abstract_id": "24383406", "label": "objective", "text": "To evaluate changes in self-reported nocturia in community-dwelling adults aged @ and older who received behavioral treatment for chronic insomnia .", "sentence_id": 0}
+{"abstract_id": "24383406", "label": "methods", "text": "Secondary analysis of a randomized controlled trial of a behavioral intervention for sleep .", "sentence_id": 1}
+{"abstract_id": "24383406", "label": "methods", "text": "Academic medical center .", "sentence_id": 2}
+{"abstract_id": "24383406", "label": "methods", "text": "Of the @ enrollees , this analysis focused on @ who , in addition to insomnia , also reported at least one nightly episode of waking up to void .", "sentence_id": 3}
+{"abstract_id": "24383406", "label": "methods", "text": "The brief behavioral treatment of insomnia ( BBTI ) group ( n = @ ) received instructions on reducing time in bed and setting a regular sleep schedule .", "sentence_id": 4}
+{"abstract_id": "24383406", "label": "methods", "text": "The information control ( IC ) group ( n = @ ) received printed materials .", "sentence_id": 5}
+{"abstract_id": "24383406", "label": "methods", "text": "A nurse clinician delivered both interventions .", "sentence_id": 6}
+{"abstract_id": "24383406", "label": "methods", "text": "Self-reported nocturnal awakenings to void assessed daily for @ days at baseline and @ weeks after the intervention .", "sentence_id": 7}
+{"abstract_id": "24383406", "label": "methods", "text": "Participants who reported at least one episode of nocturia per night at baseline were included in this analysis .", "sentence_id": 8}
+{"abstract_id": "24383406", "label": "results", "text": "In individuals with nocturia at baseline , the total number of nocturnal voids over the @-day assessment period decreased by @ @ in the BBTI group and increased by @ @ in the IC group ( P = @ , effect size @ ) .", "sentence_id": 9}
+{"abstract_id": "24383406", "label": "results", "text": "After adjusting for baseline nocturia episodes , the difference remained significant ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24383406", "label": "conclusions", "text": "In older adults with concurrent insomnia and nocturia , behavioral treatment directed solely at insomnia may also improve self-reported nocturia .", "sentence_id": 11}
+{"abstract_id": "24383406", "label": "conclusions", "text": "Behavioral treatment of insomnia should be further investigated for its effect on nocturia in individuals with concurrent insomnia and nocturia .", "sentence_id": 12}
+{"abstract_id": "25520340", "label": "background", "text": "Attempts to improve proximal load transfer and minimize stress shielding have included reducing the stiffness of femoral stems and using alternative stem materials , including carbon fiber composites .", "sentence_id": 0}
+{"abstract_id": "25520340", "label": "background", "text": "An uncemented implant ( SR@ ) composed of a carbon-fiber-composite distal section and a porous-coated titanium-alloy proximal section , designed to improve proximal load transfer and provide good fixation , was clinically evaluated in a prospective randomized study .", "sentence_id": 1}
+{"abstract_id": "25520340", "label": "methods", "text": "Sixty patients were enrolled and randomized to receive either the SR@ stem or an all-metal stem ( Stability ) .", "sentence_id": 2}
+{"abstract_id": "25520340", "label": "methods", "text": "All patients received a cemented all-polyethylene acetabular component and a @-mm metal femoral head .", "sentence_id": 3}
+{"abstract_id": "25520340", "label": "methods", "text": "All uncemented stems were implanted by the same surgeon .", "sentence_id": 4}
+{"abstract_id": "25520340", "label": "methods", "text": "Patients were followed for up to ten years with repeated assessments of bone mineral density , radiographs , Harris hip scores ( HHS ) , and visual analog scale ( VAS ) pain scores .", "sentence_id": 5}
+{"abstract_id": "25520340", "label": "results", "text": "Ten years postoperatively , nineteen patients who had been treated with the SR@ stem and not lost to follow-up showed a significantly greater increase in proximal bone mineral density ( Gruen zones @ -LSB- p = @ -RSB- and @ -LSB- p = @ -RSB- ) from baseline than did the twenty-two who had been treated with the Stability stem and not lost to follow-up .", "sentence_id": 6}
+{"abstract_id": "25520340", "label": "results", "text": "In contrast , the Stability group showed a significantly greater increase in distal bone mineral density ( Gruen zones @ -LSB- p = @ -RSB- , @ -LSB- p = @ -RSB- , and @ -LSB- p = @ -RSB- ) compared with the SR@ group .", "sentence_id": 7}
+{"abstract_id": "25520340", "label": "results", "text": "Radiographs demonstrated one case of progressive migration of an acetabular component used with an SR@ stem and one case of bone resorption in Gruen zones @ and @ in a patient treated with a Stability stem .", "sentence_id": 8}
+{"abstract_id": "25520340", "label": "results", "text": "There was no significant difference between the SR@ and Stability stems in terms of changes in the total HHS , HHS for pain , HHS for range of motion , or VAS pain scores ten years postoperatively relative to preoperative levels .", "sentence_id": 9}
+{"abstract_id": "25520340", "label": "results", "text": "There was one reported revision of an SR@ femoral stem at the ten-year review .", "sentence_id": 10}
+{"abstract_id": "25520340", "label": "conclusions", "text": "The investigational SR@ implant provided increased proximal bone density and reduced distal bone density .", "sentence_id": 11}
+{"abstract_id": "25520340", "label": "conclusions", "text": "The implant showed promising results at the time of early follow-up , and the clinical outcomes were similar to those of an all-metal stem at the time of a ten-year follow-up .", "sentence_id": 12}
+{"abstract_id": "24252596", "label": "background", "text": "Coronary artery disease ( CAD ) is accountable for more than @ million deaths each year according to the World Health Organization ( WHO ) .", "sentence_id": 0}
+{"abstract_id": "24252596", "label": "background", "text": "In a European population @ % of patients diagnosed with CAD are overweight and @ % are obese .", "sentence_id": 1}
+{"abstract_id": "24252596", "label": "background", "text": "Physical inactivity and overweight are major risk factors in CAD , thus central strategies in secondary prevention are increased physical activity and weight loss .", "sentence_id": 2}
+{"abstract_id": "24252596", "label": "methods", "text": "In a randomized controlled trial @ participants with stable CAD , age @-@ , body mass index @-@kg / m@ and no diabetes are randomized ( @:@ ) to @weeks of intensive exercise or weight loss both succeeded by a @-week follow-up .", "sentence_id": 3}
+{"abstract_id": "24252596", "label": "methods", "text": "The exercise protocol consist of supervised aerobic interval training ( AIT ) at @-@ % of VO@peak @ times weekly for @weeks followed by supervised AIT twice weekly for @weeks .", "sentence_id": 4}
+{"abstract_id": "24252596", "label": "methods", "text": "In the weight loss arm dieticians instruct the participants in a low energy diet ( @-@kcal / day ) for @weeks , followed by @weeks of weight maintenance combined with supervised AIT twice weekly .", "sentence_id": 5}
+{"abstract_id": "24252596", "label": "methods", "text": "The primary endpoint of the study is change in coronary flow reserve after the first @weeks ' intervention .", "sentence_id": 6}
+{"abstract_id": "24252596", "label": "methods", "text": "Secondary endpoints include cardiovascular , metabolic , inflammatory and anthropometric measures .", "sentence_id": 7}
+{"abstract_id": "24252596", "label": "conclusions", "text": "The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT .", "sentence_id": 8}
+{"abstract_id": "24252596", "label": "conclusions", "text": "Additionally , it will provide new insight in mechanisms behind the benefits of exercise and weight loss .", "sentence_id": 9}
+{"abstract_id": "24252596", "label": "conclusions", "text": "We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD .", "sentence_id": 10}
+{"abstract_id": "24392223", "label": "background", "text": "The established interventions for weight loss are resource intensive which can create barriers for full participation and ultimate translation .", "sentence_id": 0}
+{"abstract_id": "24392223", "label": "background", "text": "The major goal of this pilot study was to evaluate the feasibility , acceptability , and preliminary efficacy of theoretically based behavioral interventions delivered by smartphone technology .", "sentence_id": 1}
+{"abstract_id": "24392223", "label": "methods", "text": "The study randomized @ obese adults to receive one of four interventions for six months : ( @ ) intensive counseling intervention , ( @ ) intensive counseling plus smartphone intervention , ( @ ) a less intensive counseling plus smartphone intervention , and ( @ ) smartphone intervention only .", "sentence_id": 2}
+{"abstract_id": "24392223", "label": "methods", "text": "The outcome measures of weight , BMI , waist circumference , and self-reported dietary intake and physical activity were assessed at baseline and six months .", "sentence_id": 3}
+{"abstract_id": "24392223", "label": "results", "text": "The sample was @ % female and @ % African American , with an average age of @ years , and average BMI of @ kg/m ( @ ) .", "sentence_id": 4}
+{"abstract_id": "24392223", "label": "results", "text": "There were trends for differences in weight loss among the four intervention groups .", "sentence_id": 5}
+{"abstract_id": "24392223", "label": "results", "text": "Participants in the intensive counseling plus self-monitoring smartphone group and less intensive counseling plus self-monitoring smartphone group tended to lose more weight than other groups ( @ kg and @ kg , resp . )", "sentence_id": 6}
+{"abstract_id": "24392223", "label": "conclusions", "text": "The results of this pilot trial of a weight loss intervention provide preliminary support for using a smartphone application for self-monitoring as an adjunct to behavioral counseling .", "sentence_id": 7}
+{"abstract_id": "24279519", "label": "background", "text": "Atopic dermatitis is a chronic inflammatory skin disease with a high prevalence rate and a large socioeconomic cost .", "sentence_id": 0}
+{"abstract_id": "24279519", "label": "background", "text": "There are many treatments for atopic dermatitis , such as antihistamine , tacrolimus and corticosteroids .", "sentence_id": 1}
+{"abstract_id": "24279519", "label": "background", "text": "However , due to concern about the adverse effects , many patients seek alternative treatments .", "sentence_id": 2}
+{"abstract_id": "24279519", "label": "background", "text": "In this context , natural products are gaining interest .", "sentence_id": 3}
+{"abstract_id": "24279519", "label": "background", "text": "KM@ is a functional food consisting of four herbs that are beneficial to skin health .", "sentence_id": 4}
+{"abstract_id": "24279519", "label": "background", "text": "The purpose of this study is to assess the efficacy and safety of KM@ for atopic dermatitis .", "sentence_id": 5}
+{"abstract_id": "24279519", "label": "methods", "text": "This study is a randomised , double-blind , placebo-controlled and multicentre trial of KM@ .", "sentence_id": 6}
+{"abstract_id": "24279519", "label": "methods", "text": "For this study , we will recruit @ atopic dermatitis patients of both sexes , with ages ranging from @ to @ , from three university hospitals .", "sentence_id": 7}
+{"abstract_id": "24279519", "label": "methods", "text": "The participants will receive either KM@ or a placebo twice a day for @ weeks .", "sentence_id": 8}
+{"abstract_id": "24279519", "label": "methods", "text": "The primary end point will be a change in the scoring atopic dermatitis ( SCORAD ) index .", "sentence_id": 9}
+{"abstract_id": "24279519", "label": "methods", "text": "The secondary end points will include changes to the dermatology life quality index ( DLQI ) and transepidermal water loss ( TEWL ) , among others .", "sentence_id": 10}
+{"abstract_id": "24279519", "label": "methods", "text": "The outcomes will be measured at every visit .", "sentence_id": 11}
+{"abstract_id": "24279519", "label": "methods", "text": "The study will be continued for @ weeks and will include five visits with each subject ( at screening and at @ , @ , @ and @ weeks ) .", "sentence_id": 12}
+{"abstract_id": "24279519", "label": "conclusions", "text": "This trial will provide research methodologies for evaluate clinical efficacy and safety of KM@ in adult patients with atopic dermatitis .", "sentence_id": 13}
+{"abstract_id": "24279519", "label": "conclusions", "text": "In addition , we will evaluate the changes in the general skin health status and quality of life .", "sentence_id": 14}
+{"abstract_id": "24472401", "label": "objective", "text": "The study is to investigate drug-drug interaction ( DDI ) between olmesartan medoxomil and hydrochlorothiazide ( HCTZ ) , to confirm bioequivalence ( BE ) of a new combined formulation and coadministration of separate local tablets , and to receive pharmacokinetics and tolerability of the new combined formulation after multiple doses in healthy Chinese subjects .", "sentence_id": 0}
+{"abstract_id": "24472401", "label": "methods", "text": "The @-in-@ study was separated into @ stages .", "sentence_id": 1}
+{"abstract_id": "24472401", "label": "methods", "text": "Stage @ is a four-period crossover study .", "sentence_id": 2}
+{"abstract_id": "24472401", "label": "methods", "text": "@ healthy subjects were equally randomized into four groups .", "sentence_id": 3}
+{"abstract_id": "24472401", "label": "methods", "text": "Each group received the four following regimens in a sequence as Latin square ( @ @ ) design : A : olmesartan medoxomil ; B : HCTZ ; C : test drug ( new combined formulation ) ; D : reference drugs ( co-administration of separate tablets ) .", "sentence_id": 4}
+{"abstract_id": "24472401", "label": "methods", "text": "In stage @ , half of @ subjects were daily dosed with regimen C for @ days .", "sentence_id": 5}
+{"abstract_id": "24472401", "label": "methods", "text": "Blood and urine samples were obtained to receive pharmacokinetics of olmesartan and HCTZ , which were analyzed using the BE evaluation method .", "sentence_id": 6}
+{"abstract_id": "24472401", "label": "methods", "text": "Tolerability was also assessed .", "sentence_id": 7}
+{"abstract_id": "24472401", "label": "results", "text": "All subjects completed the study and nobody reported serious adverse event ( SAE ) .", "sentence_id": 8}
+{"abstract_id": "24472401", "label": "results", "text": "The @ % confidence intervals ( CI ) of geometric mean ratio ( GMR ) of log transformed Cmax , AUC@-t , and AUC@ - after single dose showed no DDI and claimed BE .", "sentence_id": 9}
+{"abstract_id": "24472401", "label": "results", "text": "The mean ratio of accumulation ( Ra ) ( SD ) of olmesartan and HCTZ after multiple doses of new combination formulation is @ ( @ ) and @ ( @ ) .", "sentence_id": 10}
+{"abstract_id": "24472401", "label": "conclusions", "text": "No significant DDI between olmesartan and HCTZ was found .", "sentence_id": 11}
+{"abstract_id": "24472401", "label": "conclusions", "text": "The new combination formulation is bioequivalent to co-administration of two separate local tablets .", "sentence_id": 12}
+{"abstract_id": "24472401", "label": "conclusions", "text": "After multiple doses of the new combination formulation , no significant accumulation was observed .", "sentence_id": 13}
+{"abstract_id": "24472401", "label": "conclusions", "text": "The new combination formulation is reasonably tolerated well in healthy Chinese subjects after multiple doses .", "sentence_id": 14}
+{"abstract_id": "25307535", "label": "background", "text": "Achievement of target low-density lipoprotein ( LDL ) levels for secondary prevention is endorsed in Canadian guidelines but has been de-emphasized in the @ American College of Cardiology/American Heart Association coronary artery disease ( CAD ) guidelines in favor of initiation of statins or triple therapy ( antiplatelet agent , angiotensin converting enzyme inhibitor/angiotensin II receptor blocker , and statins ) .", "sentence_id": 0}
+{"abstract_id": "25307535", "label": "background", "text": "Our objective was to determine which of these @ process-of-care metrics achieved within @ months would be associated with @-year rates of death , myocardial infarction , or stroke and thus be suitable as an end point for quality improvement studies in patients with CAD .", "sentence_id": 1}
+{"abstract_id": "25307535", "label": "methods", "text": "This was a cohort study that followed @ participants for @ years after their involvement in a @-month secondary prevention trial .", "sentence_id": 2}
+{"abstract_id": "25307535", "label": "results", "text": "Over @ years , @ patients died , @ had myocardial infarction , and @ had stroke .", "sentence_id": 3}
+{"abstract_id": "25307535", "label": "results", "text": "Six months after randomization , @ ( @ % ) had achieved the LDL target ( @ mmol/L ) , @ ( @ % ) received statins , and @ ( @ % ) received triple therapy .", "sentence_id": 4}
+{"abstract_id": "25307535", "label": "results", "text": "The @-year composite event rate was significantly lower in patients who achieved the LDL target during the @-month trial than in those who did not ( @ % vs @ % ; adjusted hazard ratio -LSB- aHR -RSB- , @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) , even accounting for statin use ( adjusted P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25307535", "label": "results", "text": "Conversely , @-year event rates were not lower in patients taking statins at @ months compared with those who were not ( @ % vs @ % ; aHR , @ ; @ % CI , @-@ @ ) or in those receiving triple therapy and those who were not ( @ % vs @ % ; aHR , @ ; @ % CI , @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "25307535", "label": "conclusions", "text": "Achievement of LDL targets at @ months is suitable as a metric for CAD quality-improvement studies ; medication use alone was not independently associated with longer term outcomes .", "sentence_id": 7}
+{"abstract_id": "24945884", "label": "objective", "text": "To determine if a health communication intervention targeting parents of high-risk , urban , minority children with asthma could ( i ) improve parental perceptions of connectedness to and communication with their child 's primary care providers ( PCP ) and ( ii ) decrease reliance on emergency departments ( EDs ) and other urgent care services for their child 's asthma-related care .", "sentence_id": 0}
+{"abstract_id": "24945884", "label": "methods", "text": "The design was a single blind , parallel groups , randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24945884", "label": "methods", "text": "Parents were recruited from an ED-based asthma clinic serving primarily low-income , minority children in Washington , DC .", "sentence_id": 2}
+{"abstract_id": "24945884", "label": "methods", "text": "The intervention involved face-to-face education on effective communication followed by a single booster call .", "sentence_id": 3}
+{"abstract_id": "24945884", "label": "methods", "text": "Standardized instruments were administered to assess primary care connectedness and healthcare utilization at baseline and @ - and @-months post-enrollment .", "sentence_id": 4}
+{"abstract_id": "24945884", "label": "results", "text": "A total of @ parents of children @-@ years old were randomized ( @ intervention and @ usual care ) , and @ ( @ % ) were successfully followed for six months .", "sentence_id": 5}
+{"abstract_id": "24945884", "label": "results", "text": "Only at the two-month follow-up time-point , parents in the intervention group were significantly more likely to identify a PCP as the main source of their child 's asthma care ( adjusted odds ratio : @ , @ % confidence interval : @-@ @ ) and to report a significant reduction in ED visits for asthma care ( adjusted incidence rate ratio : @ , @ % confidence interval : @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24945884", "label": "results", "text": "There was no significant effect on parent communication self-efficacy or number of PCP visits .", "sentence_id": 7}
+{"abstract_id": "24945884", "label": "conclusions", "text": "A brief , in-person health communication intervention for parents of high-risk children with asthma resulted in improved identification of PCPs as the usual source of asthma care and reduced reliance on EDs for asthma care , albeit only for two months post-intervention .", "sentence_id": 8}
+{"abstract_id": "25246664", "label": "background", "text": "Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations .", "sentence_id": 0}
+{"abstract_id": "25246664", "label": "background", "text": "Inhaled osmotic agents may enhance mucociliary clearance , but few long-term clinical trials have been conducted .", "sentence_id": 1}
+{"abstract_id": "25246664", "label": "objective", "text": "To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic fibrosis ( CF ) bronchiectasis .", "sentence_id": 2}
+{"abstract_id": "25246664", "label": "objective", "text": "Secondary endpoints included time to first exacerbation , duration of exacerbations , antibiotic use for exacerbations and quality of life ( QOL ) ( St George 's Respiratory Questionnaire , SGRQ ) .", "sentence_id": 3}
+{"abstract_id": "25246664", "label": "methods", "text": "Patients with non-CF bronchiectasis and a history of chronic excess production of sputum and @ pulmonary exacerbations in the previous @ months were randomised ( @:@ ) to @ weeks treatment with inhaled mannitol @ mg or low-dose mannitol control twice a day .", "sentence_id": 4}
+{"abstract_id": "25246664", "label": "methods", "text": "Patients were @-@ years of age , baseline FEV@ @ % and @ % predicted and a baseline SGRQ score @ .", "sentence_id": 5}
+{"abstract_id": "25246664", "label": "results", "text": "@ patients ( @ in the mannitol and @ in the control arm ) were treated .", "sentence_id": 6}
+{"abstract_id": "25246664", "label": "results", "text": "Baseline demographics were similar in the two arms .", "sentence_id": 7}
+{"abstract_id": "25246664", "label": "results", "text": "The exacerbation rate was not significantly reduced on mannitol ( rate ratio @ , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25246664", "label": "results", "text": "However , time to first exacerbation was increased on mannitol ( HR @ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25246664", "label": "results", "text": "SGRQ score was improved on mannitol compared with low-dose mannitol control ( -@ units , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25246664", "label": "results", "text": "Adverse events were similar between groups .", "sentence_id": 11}
+{"abstract_id": "25246664", "label": "conclusions", "text": "Mannitol @ mg inhaled twice daily for @ months in patients with clinically significant bronchiectasis did not significantly reduce exacerbation rates .", "sentence_id": 12}
+{"abstract_id": "25246664", "label": "conclusions", "text": "There were statistically significant improvements in time to first exacerbation and QOL .", "sentence_id": 13}
+{"abstract_id": "25246664", "label": "conclusions", "text": "Mannitol therapy was safe and well tolerated .", "sentence_id": 14}
+{"abstract_id": "25318000", "label": "objective", "text": "To evaluate the pain on injection of propofol via different combinations of fentanyl , sufentanil or remifentanil in gastrointestinal endoscopy .", "sentence_id": 0}
+{"abstract_id": "25318000", "label": "methods", "text": "Total @ patients were randomly allocated into @ groups .", "sentence_id": 1}
+{"abstract_id": "25318000", "label": "methods", "text": "Propofol & fentanil ( PF ) group received @ g/kg fentanyl , propofol & sufentanil ( PS ) group received @ g/kg sufentanil and propofol & remifentanyl ( PR ) group received @ g/kg remifentanyl prior to administration of @-@ mg/kg of propofol .", "sentence_id": 2}
+{"abstract_id": "25318000", "label": "methods", "text": "The propofol & half-fentanil ( Pf ) group , propofol & half-sufentanil ( Ps ) group and propofol & half-remifentanyl ( Pr ) group were given @ g/kg fentanyl , @ g/kg sufentanil and @ g/kg remifentanyl , respectively and later administrated @-@ mg/kg propofol .", "sentence_id": 3}
+{"abstract_id": "25318000", "label": "methods", "text": "All patients were monitored for the blood pressure ( MAP ) , heart rate ( HR ) , and oxygen saturation ( SpO@ ) .", "sentence_id": 4}
+{"abstract_id": "25318000", "label": "methods", "text": "Additionally , the pain intensity was assessed using a @-point verbal rating scale ( VRS ) by professional doctors .", "sentence_id": 5}
+{"abstract_id": "25318000", "label": "results", "text": "The incidence of pain due to propofol injection in Ps group ( @ % ) was significantly lower than other @ groups .", "sentence_id": 6}
+{"abstract_id": "25318000", "label": "results", "text": "The heart rate ( HR ) and mean arterial pressure ( MAP ) were maintained within the normal limits in all six groups and there was no hypotension or bradycardia encountered during the study period .", "sentence_id": 7}
+{"abstract_id": "25318000", "label": "conclusions", "text": "Propofol and sufentanil group was the most suitable program for painless gastroscopy .", "sentence_id": 8}
+{"abstract_id": "24393414", "label": "background", "text": "The use of firocoxib in horses and its ability to affect performance and potential to allow a horse to compete when it otherwise should not , necessitates establishing appropriate withdrawal time guidelines prior to performance .", "sentence_id": 0}
+{"abstract_id": "24393414", "label": "objective", "text": "To describe plasma concentrations and characterise the pharmacokinetics of @ firocoxib formulations following multiple administrations of the label dose , with respect to recommended plasma thresholds for performance horses .", "sentence_id": 1}
+{"abstract_id": "24393414", "label": "methods", "text": "Balanced @-way crossover prospective study .", "sentence_id": 2}
+{"abstract_id": "24393414", "label": "methods", "text": "Nine healthy mature horses were administered firocoxib injectable solution ( @ mg/kg bwt i.v. s.i.d. for @ days ) , firocoxib paste ( @ mg/kg bwt per os s.i.d. for @ days ) and firocoxib tablets ( @mg s.i.d. for @ days ) .", "sentence_id": 3}
+{"abstract_id": "24393414", "label": "methods", "text": "Blood samples were collected at Time @ and at various times post drug administration until plasma concentrations were below the limit of detection of the assay .", "sentence_id": 4}
+{"abstract_id": "24393414", "label": "methods", "text": "Plasma samples were analysed using liquid chromatography-mass spectrometry and data analysed using noncompartmental analysis .", "sentence_id": 5}
+{"abstract_id": "24393414", "label": "results", "text": "The mean plasma half-life was @ @ , @ @ and @ @ days for injectable , paste and tablet formulations , respectively .", "sentence_id": 6}
+{"abstract_id": "24393414", "label": "results", "text": "Plasma concentrations fell below the Racing Medication and Testing Consortium 's recommended threshold for racehorses ( @ng/ml ) by @ days post administration of the final dose for all formulations .", "sentence_id": 7}
+{"abstract_id": "24393414", "label": "results", "text": "Plasma concentrations never exceeded the threshold concentration ( @ng/ml ) for horse competing in US Equestrian Federation events for any of the formulations .", "sentence_id": 8}
+{"abstract_id": "24393414", "label": "conclusions", "text": "This study extends current knowledge regarding the pharmacokinetics of firocoxib and provides information that can be used to establish appropriate withdrawal time guidelines following multiple administrations , with respect to already established plasma regulatory threshold concentrations .", "sentence_id": 9}
+{"abstract_id": "25404142", "label": "background", "text": "The study investigated the long-term effectiveness of the adolescent cognitive behavioral resiliency training Op Volle Kracht ( OVK ) on the secondary outcomes : anxiety symptoms , hopelessness , happiness , life satisfaction , optimism , coping , self-efficacy , and school functioning .", "sentence_id": 0}
+{"abstract_id": "25404142", "label": "background", "text": "In addition , the study analyzed whether the secondary outcomes moderated the intervention effect on depressive symptoms .", "sentence_id": 1}
+{"abstract_id": "25404142", "label": "methods", "text": "A two-condition ( intervention and control ) cluster randomized controlled trial was conducted .", "sentence_id": 2}
+{"abstract_id": "25404142", "label": "methods", "text": "All adolescents in the @th grade were eligible to participate , unless they , or their parents , declined their participation .", "sentence_id": 3}
+{"abstract_id": "25404142", "label": "methods", "text": "Schools were the unit of randomization .", "sentence_id": 4}
+{"abstract_id": "25404142", "label": "methods", "text": "Missing data were imputed and intent to treat analyses were conducted .", "sentence_id": 5}
+{"abstract_id": "25404142", "label": "methods", "text": "The results were analyzed using Latent Growth Curve Modeling across the @-months follow-up period .", "sentence_id": 6}
+{"abstract_id": "25404142", "label": "results", "text": "The total sample consisted of @ adolescents ( Mage = @ , SD = @ , @ % girls , @ % Dutch ethnicity ) .", "sentence_id": 7}
+{"abstract_id": "25404142", "label": "results", "text": "The intervention and control condition consisted of @ adolescents from @ schools and @ adolescents from @ schools , respectively .", "sentence_id": 8}
+{"abstract_id": "25404142", "label": "results", "text": "OVK did not have an effect on depression , anxiety , hopelessness , happiness , and life satisfaction , but promoted cognitive coping over the course of the follow-up period .", "sentence_id": 9}
+{"abstract_id": "25404142", "label": "results", "text": "OVK showed small iatrogenic effects on optimism , active coping , social self-efficacy and school grades directly post intervention , but these effects disappeared during the follow-up period .", "sentence_id": 10}
+{"abstract_id": "25404142", "label": "results", "text": "Finally , none of the outcome variables moderated the intervention effect on depressive symptoms .", "sentence_id": 11}
+{"abstract_id": "25404142", "label": "conclusions", "text": "The universal resiliency training OVK was not effective in this Dutch sample .", "sentence_id": 12}
+{"abstract_id": "25404142", "label": "conclusions", "text": "Implications for research and practice were discussed .", "sentence_id": 13}
+{"abstract_id": "25441065", "label": "background", "text": "Minimally invasive surgical procedures ( MIS ) may offer several advantages over conventional full sternotomy ( FS ) aortic valve replacement ( AVR ) .", "sentence_id": 0}
+{"abstract_id": "25441065", "label": "background", "text": "A novel class of aortic valve prostheses has been developed for rapid-deployment AVR ( RDAVR ) .", "sentence_id": 1}
+{"abstract_id": "25441065", "label": "background", "text": "We report a randomized , multicenter trial comparing the outcomes for MIS-RDAVR with those of conventional FS-AVR .", "sentence_id": 2}
+{"abstract_id": "25441065", "label": "methods", "text": "A total of @ patients with aortic stenosis were enrolled in a prospective , multicenter , randomized comparison trial ( CADENCE-MIS ) .", "sentence_id": 3}
+{"abstract_id": "25441065", "label": "methods", "text": "Exclusion criteria included ejection fraction below @ % , AVR requiring concomitant procedures , and recent myocardial infarction or stroke .", "sentence_id": 4}
+{"abstract_id": "25441065", "label": "methods", "text": "Patients were randomized to undergo MIS-RDAVR through an upper hemisternotomy ( n = @ ) or AVR by FS with a conventional stented bioprosthesis ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25441065", "label": "methods", "text": "Three patients were excluded before the procedure , and @ more patients who were randomized to undergo RDAVR were excluded because of their anatomy .", "sentence_id": 6}
+{"abstract_id": "25441065", "label": "methods", "text": "Procedural , early clinical outcomes , and functional outcomes were assessed for the remaining @ patients .", "sentence_id": 7}
+{"abstract_id": "25441065", "label": "methods", "text": "Hemodynamic performance was assessed by an echocardiography core laboratory .", "sentence_id": 8}
+{"abstract_id": "25441065", "label": "results", "text": "Implanted valve sizes were similar between groups ( @ @ vs @ @ mm , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25441065", "label": "results", "text": "MIS-RDAVR was associated with significantly reduced aortic cross-clamp times compared with FS-AVR ( @ @ vs @ @ minutes , p < @ ) , although cardiopulmonary bypass times were similar ( @ @ vs @ @ minutes , p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25441065", "label": "results", "text": "Early clinical outcomes were similar between the two groups , including quality of life measures .", "sentence_id": 11}
+{"abstract_id": "25441065", "label": "results", "text": "The RDAVR patients had a significantly lower mean transvalvular gradient ( @ vs @ mm Hg , p = @ ) and a lower prevalence of patient-prosthesis mismatch ( @ % vs @ % , p = @ ) @ months postoperatively compared with the FS-AVR patients .", "sentence_id": 12}
+{"abstract_id": "25441065", "label": "conclusions", "text": "RDAVR by the MIS approach is associated with significantly reduced myocardial ischemic time and better valvular hemodynamic function than FS-AVR with a conventional stented bioprosthesis .", "sentence_id": 13}
+{"abstract_id": "25441065", "label": "conclusions", "text": "Rapid deployment valves may facilitate the performance of MIS-AVR .", "sentence_id": 14}
+{"abstract_id": "25555887", "label": "objective", "text": "We aim to examine predictors of opiate abstinence status @ months after the end of buprenorphine/naloxone treatment for opioid-dependent participants .", "sentence_id": 0}
+{"abstract_id": "25555887", "label": "methods", "text": "Participants ( n = @ , age > @ years ) received buprenorphine / naloxone treatment for @ weeks and then randomly assigned to undergo dose tapering over either @ days or @ days .", "sentence_id": 1}
+{"abstract_id": "25555887", "label": "methods", "text": "Bivariate analysis was performed to identify possible predictors of successful opiate abstinence outome ( p-value < @ ) .", "sentence_id": 2}
+{"abstract_id": "25555887", "label": "methods", "text": "Logistic regression analysis with backward stepwise selection was , then , performed to produce final model containing independent predictors at p-value < @ .", "sentence_id": 3}
+{"abstract_id": "25555887", "label": "results", "text": "Bivariate analysis identified several possible predictors including : opioid and drug urine tests result at the end taper ; employment status , family problems , and alcohol use domains of addiction severity index ( ASI ) score ; and clinical opiate withdrawal scale ( COWS ) at the end of stabilization .", "sentence_id": 4}
+{"abstract_id": "25555887", "label": "results", "text": "Final predictor list identified by logistic regression include : ASI score for family and alcohol problems , COWS at the end of stabilization and opiate urine test at the end of taper .", "sentence_id": 5}
+{"abstract_id": "25555887", "label": "conclusions", "text": "Participants presenting with a negative urine test for opiate , more severe alcohol , more severe family problems , or more symptoms of opiate withdrawal at the end of stabilization were more likely to have a successful opiate abstinence .", "sentence_id": 6}
+{"abstract_id": "26176357", "label": "background", "text": "The anxiolytic efficacy of video watching , in the absence of parents , during the mask induction of anesthesia in young children with high separation anxiety has not been clearly established .", "sentence_id": 0}
+{"abstract_id": "26176357", "label": "background", "text": "We performed this study to determine whether the effect of video distraction on alleviating preoperative anxiety is independent of parental presence and whether a combination of both interventions is more effective than either single intervention in alleviating preoperative anxiety and postoperative behavioral disturbance in preschool children .", "sentence_id": 1}
+{"abstract_id": "26176357", "label": "methods", "text": "In this prospective trial , @ children aged @ to @ years scheduled for elective minor surgery were randomly allocated to @ of @ groups , a video distraction group ( group V ) , a parental presence group ( group P ) , or a combination of video distraction plus parental presence group ( group VP ) during induction of sevoflurane anesthesia .", "sentence_id": 2}
+{"abstract_id": "26176357", "label": "methods", "text": "The Modified Yale Preoperative Anxiety Scale ( mYPAS ) was used to assess anxiety in the preoperative holding area ( baseline ) , immediately after entry to the operating room , and during mask induction .", "sentence_id": 3}
+{"abstract_id": "26176357", "label": "methods", "text": "Compliance during induction , emergence delirium during recovery , and negative behavioral changes at @ day and @ weeks postoperatively were also assessed .", "sentence_id": 4}
+{"abstract_id": "26176357", "label": "results", "text": "The mYPAS scores were comparable ( P = @ ) , and the number of children exhibiting baseline anxiety ( an mYPAS score > @ ) were not different among the @ groups in the preoperative holding area ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "26176357", "label": "results", "text": "After intervention , the changes in mYPAS scores from baseline to induction were not different among the @ groups ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26176357", "label": "results", "text": "The proportion of children with increased mYPAS scores was higher in group P compared with group V from baseline to operating room entry ( Bonferroni-adjusted @ % confidence interval for difference , @ to @ ) but similar from baseline to induction in all @ groups .", "sentence_id": 7}
+{"abstract_id": "26176357", "label": "results", "text": "Although children in group V were more cooperative during mask induction than those in the other @ groups ( P < @ versus group P and P = @ versus group VP ) , no significant intergroup differences were observed in the incidence of emergence delirium or new-onset negative behavioral change after surgery .", "sentence_id": 8}
+{"abstract_id": "26176357", "label": "conclusions", "text": "Video distraction , parental presence , or their combination showed similar effects on preoperative anxiety during inhaled induction of anesthesia and postoperative behavioral outcomes in preschool children having surgery .", "sentence_id": 9}
+{"abstract_id": "24967362", "label": "objective", "text": "Methotrexate ( MTX ) , the most used drug in rheumatoid arthritis ( RA ) treatment , showing variability in clinical response , is often associated with genetic polymorphisms .", "sentence_id": 0}
+{"abstract_id": "24967362", "label": "objective", "text": "This study aimed to elucidate the role of methylenetetrahydrofolate reductase ( MTHFR ) C@T and aminoimidazole carboxamide adenosine ribonucleotide transformylase ( ATIC ) T@C polymorphisms and clinicopathological variables in clinical response to MTX in Portuguese RA patients .", "sentence_id": 1}
+{"abstract_id": "24967362", "label": "methods", "text": "Study included @ RA patients treated with MTX for at least six months .", "sentence_id": 2}
+{"abstract_id": "24967362", "label": "methods", "text": "MTHFR C@T and ATIC T@C polymorphisms were genotyped and clinicopathological variables were collected .", "sentence_id": 3}
+{"abstract_id": "24967362", "label": "methods", "text": "Statistical analyses were performed and binary logistic regression method adjusted to possible confounding variables .", "sentence_id": 4}
+{"abstract_id": "24967362", "label": "results", "text": "Multivariate analyses demonstrated that MTHFR @TT ( OR = @ ; P = @ ) and ATIC @T carriers ( OR = @ ; P = @ ) were associated with over @-fold increased risk for nonresponse .", "sentence_id": 5}
+{"abstract_id": "24967362", "label": "results", "text": "For clinicopathological variables , noncurrent smokers ( OR = @ ; P = @ ) , patients positive to anti-cyclic citrullinated peptide ( OR = @ ; P = @ ) and antinuclear antibodies ( OR = @ ; P = @ ) , with higher health assessment questionnaire score ( OR = @ ; P = @ ) , and nonsteroidal anti-inflammatory drug users ( OR = @ ; P = @ ) were also associated with nonresponse .", "sentence_id": 6}
+{"abstract_id": "24967362", "label": "results", "text": "Contrarily , subcutaneous administration route ( OR = @ ; P < @ ) was associated with response .", "sentence_id": 7}
+{"abstract_id": "24967362", "label": "conclusions", "text": "Our study suggests that MTHFR C@T and ATIC T@C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and , therefore , assist clinicians in personalizing RA treatment .", "sentence_id": 8}
+{"abstract_id": "24725239", "label": "background", "text": "In phase @ studies , treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS@A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus ( HCV ) genotype @ infection .", "sentence_id": 0}
+{"abstract_id": "24725239", "label": "methods", "text": "We conducted a phase @ , open-label study involving previously untreated patients with chronic HCV genotype @ infection .", "sentence_id": 1}
+{"abstract_id": "24725239", "label": "methods", "text": "Patients were randomly assigned in a @:@:@:@ ratio to receive ledipasvir and sofosbuvir in a fixed-dose combination tablet once daily for @ weeks , ledipasvir-sofosbuvir plus ribavirin for @ weeks , ledipasvir-sofosbuvir for @ weeks , or ledipasvir-sofosbuvir plus ribavirin for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24725239", "label": "methods", "text": "The primary end point was a sustained virologic response at @ weeks after the end of therapy .", "sentence_id": 3}
+{"abstract_id": "24725239", "label": "results", "text": "Of the @ patients who underwent randomization and were treated , @ % had cirrhosis , @ % were black , and @ % had HCV genotype @a infection .", "sentence_id": 4}
+{"abstract_id": "24725239", "label": "results", "text": "The rates of sustained virologic response were @ % ( @ % confidence interval -LSB- CI -RSB- , @ to @ ) in the group that received @ weeks of ledipasvir-sofosbuvir ; @ % ( @ % CI , @ to @ ) in the group that received @ weeks of ledipasvir-sofosbuvir plus ribavirin ; @ % ( @ % CI , @ to @ ) in the group that received @ weeks of ledipasvir-sofosbuvir ; and @ % ( @ % CI , @ to @ ) in the group that received @ weeks of ledipasvir-sofosbuvir plus ribavirin .", "sentence_id": 5}
+{"abstract_id": "24725239", "label": "results", "text": "No patient in either @-week group discontinued ledipasvir-sofosbuvir owing to an adverse event .", "sentence_id": 6}
+{"abstract_id": "24725239", "label": "results", "text": "The most common adverse events were fatigue , headache , insomnia , and nausea .", "sentence_id": 7}
+{"abstract_id": "24725239", "label": "conclusions", "text": "Once-daily ledipasvir-sofosbuvir with or without ribavirin for @ or @ weeks was highly effective in previously untreated patients with HCV genotype @ infection .", "sentence_id": 8}
+{"abstract_id": "24725239", "label": "conclusions", "text": "( Funded by Gilead Sciences ; ION-@ ClinicalTrials.gov number NCT@ . )", "sentence_id": 9}
+{"abstract_id": "25297681", "label": "objective", "text": "Providing effective analgesia for total knee arthroplasty ( TKA ) patients remains challenging .", "sentence_id": 0}
+{"abstract_id": "25297681", "label": "objective", "text": "Femoral nerve block ( FNB ) offers targeted pain control ; however , its effect on motor function , related fall risk and impact on rehabilitation has been the source of controversy .", "sentence_id": 1}
+{"abstract_id": "25297681", "label": "objective", "text": "Adductor canal block ( ACB ) potentially spares motor fibres of the femoral nerve , but the comparative effect of the two approaches has not yet been well defined due to considerable variability in pain perception .", "sentence_id": 2}
+{"abstract_id": "25297681", "label": "objective", "text": "Our study compares both single-shot FNB and ACB , side to side , in the same patients undergoing bilateral TKA .", "sentence_id": 3}
+{"abstract_id": "25297681", "label": "methods", "text": "Sixty patients scheduled for bilateral TKA were randomised to receive ultrasound-guided FNB on one leg and ACB on the other , in addition to combined spinal epidural anaesthesia .", "sentence_id": 4}
+{"abstract_id": "25297681", "label": "methods", "text": "The primary outcome was comparative postoperative pain in either extremity at six to eight , @ and @ hours postoperatively .", "sentence_id": 5}
+{"abstract_id": "25297681", "label": "methods", "text": "Secondary comparative outcomes included motor strength ( manually and via dynamometer ) , physical therapy milestones and patient satisfaction .", "sentence_id": 6}
+{"abstract_id": "25297681", "label": "results", "text": "While pain levels were lowest at six to eight hours postoperatively and increased thereafter ( P < @ ) , no significant differences were seen between extremities at any time point with regard to pain in the quantitative comparison using visual analogue scale ( VAS ) scores ( P = @ ) , motor strength ( P = @ ) , physical therapy milestones or patient satisfaction .", "sentence_id": 7}
+{"abstract_id": "25297681", "label": "results", "text": "However , in the qualitative comparison , a significant proportion of patients reported the leg receiving ACB to be more painful than that receiving FNB at @ h -LSB- @ % ( n = @ ) vs @ % ( n = @ ) , P = @ ) -RSB- .", "sentence_id": 8}
+{"abstract_id": "25297681", "label": "conclusions", "text": "Although we could not confirm a benefit in motor function between ACB and FNB , given the equivalent analgesic potency combined with its potentially lower overall impact if neuropraxia should occur , ACB may represent an attractive alternative to FNB .", "sentence_id": 9}
+{"abstract_id": "25002671", "label": "objective", "text": "To assess the effectiveness of in-person and webinar-delivered AFIX ( Assessment , Feedback , Incentives , and eXchange ) consultations for increasing adolescent vaccine coverage .", "sentence_id": 0}
+{"abstract_id": "25002671", "label": "methods", "text": "We randomly assigned @ primary care clinics in North Carolina , serving @ adolescents , to receive no consultation or an in-person or webinar AFIX consultation .", "sentence_id": 1}
+{"abstract_id": "25002671", "label": "methods", "text": "We delivered in-person consultations in April through May @ and webinar consultations in May through August @ .", "sentence_id": 2}
+{"abstract_id": "25002671", "label": "methods", "text": "The state 's immunization registry provided vaccine coverage data for younger patients ( ages @-@ years ) and older patients ( ages @-@ years ) for @ adolescent vaccines : tetanus toxoid , reduced diphtheria toxoid , and acellular pertussis ( Tdap ) ; meningococcal ; and human papillomavirus ( HPV ) vaccines ( @ dose , females only ) .", "sentence_id": 3}
+{"abstract_id": "25002671", "label": "results", "text": "At the @-month follow-up , AFIX consultations increased vaccine coverage among younger adolescents .", "sentence_id": 4}
+{"abstract_id": "25002671", "label": "results", "text": "Patients in the in-person arm experienced coverage changes that exceeded those in the control arm for Tdap ( @ % -LSB- @ % confidence interval ( CI ) : @ to @ -RSB- ) , meningococcal ( @ % -LSB- @ % CI : @ to @ -RSB- , and HPV ( @ % -LSB- @ % CI : @ to @ -RSB- ) vaccines .", "sentence_id": 5}
+{"abstract_id": "25002671", "label": "results", "text": "Patients in the webinar versus control arm also experienced larger changes for these vaccines .", "sentence_id": 6}
+{"abstract_id": "25002671", "label": "results", "text": "AFIX did little to improve coverage among older adolescents .", "sentence_id": 7}
+{"abstract_id": "25002671", "label": "results", "text": "At @ year , the @ arms showed similar coverage changes .", "sentence_id": 8}
+{"abstract_id": "25002671", "label": "results", "text": "The effectiveness of in-person and webinar consultations was not statistically different at either time point ( all , P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25002671", "label": "conclusions", "text": "Webinar AFIX consultations were as effective as in-person consultations in achieving short-term increases in vaccine coverage for younger adolescents .", "sentence_id": 10}
+{"abstract_id": "25002671", "label": "conclusions", "text": "AFIX consultations for adolescents need improvement to have a stronger and more durable impact , especially for HPV vaccine .", "sentence_id": 11}
+{"abstract_id": "25599904", "label": "background", "text": "With increasing evidence demonstrating the effectiveness of Web-based interventions and mindfulness-based training in improving health , delivering mindfulness training online is an attractive proposition .", "sentence_id": 0}
+{"abstract_id": "25599904", "label": "objective", "text": "The aim of this study was to evaluate the efficacy of two Internet-based interventions ( basic mindfulness and Health Action Process Approach enhanced mindfulness ) with waitlist control .", "sentence_id": 1}
+{"abstract_id": "25599904", "label": "objective", "text": "Health Action Process Approach ( HAPA ) principles were used to enhance participants ' efficacy and planning .", "sentence_id": 2}
+{"abstract_id": "25599904", "label": "methods", "text": "Participants were recruited online and offline among local universities ; @ university students and staff were randomly assigned to three conditions .", "sentence_id": 3}
+{"abstract_id": "25599904", "label": "methods", "text": "The basic and HAPA-enhanced groups completed the @-week fully automated mindfulness training online .", "sentence_id": 4}
+{"abstract_id": "25599904", "label": "methods", "text": "All participants ( including control ) were asked to complete an online questionnaire pre-program , post-program , and at @-month follow-up .", "sentence_id": 5}
+{"abstract_id": "25599904", "label": "results", "text": "Significant group by time interaction effect was found .", "sentence_id": 6}
+{"abstract_id": "25599904", "label": "results", "text": "The HAPA-enhanced group showed significantly higher levels of mindfulness from pre-intervention to post-intervention , and such improvement was sustained at follow-up .", "sentence_id": 7}
+{"abstract_id": "25599904", "label": "results", "text": "Both the basic and HAPA-enhanced mindfulness groups showed better mental well-being from pre-intervention to post-intervention , and improvement was sustained at @-month follow-up .", "sentence_id": 8}
+{"abstract_id": "25599904", "label": "conclusions", "text": "Online mindfulness training can improve mental health .", "sentence_id": 9}
+{"abstract_id": "25599904", "label": "conclusions", "text": "An online platform is a viable medium to implement and disseminate evidence-based interventions and is a highly scalable approach to reach the general public .", "sentence_id": 10}
+{"abstract_id": "25659140", "label": "objective", "text": "Skin temperature assessment has historically been undertaken with conductive devices affixed to the skin .", "sentence_id": 0}
+{"abstract_id": "25659140", "label": "objective", "text": "With the development of technology , infrared devices are increasingly utilised in the measurement of skin temperature .", "sentence_id": 1}
+{"abstract_id": "25659140", "label": "objective", "text": "Therefore , our purpose was to evaluate the agreement between four skin temperature devices at rest , during exercise in the heat , and recovery .", "sentence_id": 2}
+{"abstract_id": "25659140", "label": "methods", "text": "Mean skin temperature ( -LSB- Formula : see text -RSB- ) was assessed in thirty healthy males during @ min rest ( @ @ C , @ @ % ) , @ min cycle in the heat ( @ @ C , @ @ % ) , and @ min recovery ( @ @ C , @ @ % ) .", "sentence_id": 3}
+{"abstract_id": "25659140", "label": "methods", "text": "-LSB- Formula : see text -RSB- was assessed at four sites using two conductive devices ( thermistors , iButtons ) and two infrared devices ( infrared thermometer , infrared camera ) .", "sentence_id": 4}
+{"abstract_id": "25659140", "label": "results", "text": "Bland-Altman plots demonstrated mean bias limits of agreement between the thermistors and iButtons as follows ( rest , exercise , recovery ) : -@ @ , @ @ , -@ @ C ; thermistors and infrared thermometer : @ @ , -@ @ , -@ @ C ; thermistors and infrared camera ( rest , recovery ) : @ @ , @ @ C. Pairwise comparisons of -LSB- Formula : see text -RSB- found significant differences ( p < @ ) between thermistors and both infrared devices during resting conditions , and significant differences between the thermistors and all other devices tested during exercise in the heat and recovery .", "sentence_id": 5}
+{"abstract_id": "25659140", "label": "conclusions", "text": "These results indicate poor agreement between conductive and infrared devices at rest , during exercise in the heat , and subsequent recovery .", "sentence_id": 6}
+{"abstract_id": "25659140", "label": "conclusions", "text": "Infrared devices may not be suitable for monitoring -LSB- Formula : see text -RSB- in the presence of , or following , metabolic and environmental induced heat stress .", "sentence_id": 7}
+{"abstract_id": "24345601", "label": "objective", "text": "This study examined the effectiveness of a fully automated web-based programme to increase physical activity in adults with Type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24345601", "label": "methods", "text": "Between May and July @ , participants were randomly allocated into either a @-week intervention ( n = @ ) or a control ( n = @ ) group .", "sentence_id": 1}
+{"abstract_id": "24345601", "label": "methods", "text": "Participants were adults diagnosed with Type @ diabetes , residing in Australia .", "sentence_id": 2}
+{"abstract_id": "24345601", "label": "methods", "text": "Participants were assessed at baseline , @ and @weeks .", "sentence_id": 3}
+{"abstract_id": "24345601", "label": "methods", "text": "The primary physical activity outcome was self-reported minutes of total physical activity .", "sentence_id": 4}
+{"abstract_id": "24345601", "label": "methods", "text": "Secondary physical activity outcomes included minutes spent walking , and engaged in moderate , and vigorous physical activity .", "sentence_id": 5}
+{"abstract_id": "24345601", "label": "methods", "text": "Additional measures included website satisfaction and website usage .", "sentence_id": 6}
+{"abstract_id": "24345601", "label": "methods", "text": "The intervention consisted of a @-week web-based physical activity intervention developed based on the Theory of Planned Behavior and self-management framework .", "sentence_id": 7}
+{"abstract_id": "24345601", "label": "methods", "text": "Data were analysed from @ to @ .", "sentence_id": 8}
+{"abstract_id": "24345601", "label": "results", "text": "There was a significant group-by-time interaction ( X ( @ ) ( df = @ ) = @ , p < @ ) for total physical activity favouring the intervention group d = @ , for those who completed the intervention , however this was not significant in the intention-to-treat analysis d = @ .", "sentence_id": 9}
+{"abstract_id": "24345601", "label": "results", "text": "The intervention yielded high website satisfaction and usage .", "sentence_id": 10}
+{"abstract_id": "24345601", "label": "conclusions", "text": "In general , there is some evidence for the effectiveness of web-based interventions for improving physical activity levels ; however it is clear that maintaining improvements remains an issue .", "sentence_id": 11}
+{"abstract_id": "24322433", "label": "objective", "text": "The aim of this study was to compare whether the effectiveness of continuous ultrasound ( US ) was superior against pulsed US and against sham US in knee osteoarthritis .", "sentence_id": 0}
+{"abstract_id": "24322433", "label": "methods", "text": "A randomized controlled study was carried out on @ patients diagnosed with knee osteoarthritis according to American College of Rheumatology .", "sentence_id": 1}
+{"abstract_id": "24322433", "label": "methods", "text": "The patients were randomized into the following three treatments : ( @ ) continuous US ( at a frequency of @ MHz with intensity of @ W/cm ) , ( @ ) pulse US ( same frequency and intensity on @:@ pulse ratio ) , and ( @ ) sham US .", "sentence_id": 2}
+{"abstract_id": "24322433", "label": "methods", "text": "All treatments were applied with @-cm head US device five times a week for @ weeks in addition to home exercise program including quadriceps isometric exercise , muscle strength exercises , and stretching exercises of the lower extremity muscles for at least three times per week .", "sentence_id": 3}
+{"abstract_id": "24322433", "label": "methods", "text": "Assessments were performed at baseline , at the end of the treatment , and at the end of the treatments and at the sixth month using the following measurements : Western Ontario and McMaster University Osteoarthritis Index-pain , stiffness , function , visual analog scale-pain at rest , visual analog scale-pain on movement , visual analog scale-disease severity , and @-m walking time .", "sentence_id": 4}
+{"abstract_id": "24322433", "label": "methods", "text": "Among these parameters , the Western Ontario and McMaster University Osteoarthritis Index-pain was the primary outcome .", "sentence_id": 5}
+{"abstract_id": "24322433", "label": "results", "text": "All groups showed a significant improvement in all parameters in both following visits ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24322433", "label": "results", "text": "However , there was no significant difference between the groups .", "sentence_id": 7}
+{"abstract_id": "24322433", "label": "results", "text": "Although the mean reduction percent in Western Ontario and McMaster University Osteoarthritis Index-pain was significantly higher in group I ( continuous US ) when compared to sham group ( @ % vs @ % , P < @ ) at the end of the treatment , this result was not found in other pain parameters .", "sentence_id": 8}
+{"abstract_id": "24322433", "label": "conclusions", "text": "The present study demonstrated that all assessment parameters significantly improved in all groups without a significant difference .", "sentence_id": 9}
+{"abstract_id": "24322433", "label": "conclusions", "text": "This result suggested that therapeutic US provided no additional benefit in improving pain and functions in addition to exercise training .", "sentence_id": 10}
+{"abstract_id": "24650828", "label": "objective", "text": "Several definitions of treatment response have been proposed for alcohol clinical trials ( e.g. , abstinence and no heavy drinking ) .", "sentence_id": 0}
+{"abstract_id": "24650828", "label": "objective", "text": "However , each of these outcomes allows only one definition of successful response .", "sentence_id": 1}
+{"abstract_id": "24650828", "label": "objective", "text": "In contrast , the cumulative proportion of responders analysis ( CPRA ) includes all of the possible drinking response cutoff points , providing a more complete picture of the therapeutic effects of a treatment .", "sentence_id": 2}
+{"abstract_id": "24650828", "label": "objective", "text": "CPRA has been used to examine the efficacy of analgesics but not alcohol pharmacotherapy .", "sentence_id": 3}
+{"abstract_id": "24650828", "label": "objective", "text": "To demonstrate its potential utility , we conducted CPRA in two large alcohol treatment trials : the COMBINE ( Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence ) trial ( naltrexone ) and a multisite topiramate trial .", "sentence_id": 4}
+{"abstract_id": "24650828", "label": "objective", "text": "CPRA was used to demonstrate the efficacy of naltrexone and topiramate on continuous measures of in-treatment drinking-heavy drinking days and drinks per day-and their reductions from pretreatment .", "sentence_id": 5}
+{"abstract_id": "24650828", "label": "methods", "text": "All possible cutoff points were portrayed for each measure .", "sentence_id": 6}
+{"abstract_id": "24650828", "label": "methods", "text": "We provide graphs to illustrate the effects of the active medications compared with placebo and examined them statistically over a number of salient drinking outcomes to evaluate their efficacy .", "sentence_id": 7}
+{"abstract_id": "24650828", "label": "results", "text": "Treatment group responder curves were not parallel across the entire range of cutoff points ; rather , they separated only at lower levels of drinking .", "sentence_id": 8}
+{"abstract_id": "24650828", "label": "results", "text": "In general , effect sizes increased by @-@ @ when going from the lowest drinking level cutoff ( i.e. , abstinence and no heavy drinking ) to the cutoff associated with the maximal treatment effect .", "sentence_id": 9}
+{"abstract_id": "24650828", "label": "conclusions", "text": "CPRA may be useful in designing subsequent trials and helping to illustrate for treatment providers the likelihood of treatment success given various definitions of a positive response .", "sentence_id": 10}
+{"abstract_id": "26434249", "label": "background", "text": "Hypertriglyceridemia is one of the risk factors for cardiovascular disease , and reduction oftriglyceride ( TG ) level is recommended in clinical practice guidelines for the treatment .", "sentence_id": 0}
+{"abstract_id": "26434249", "label": "background", "text": "Recently , andrographolide , a main active compound of Andrographispaniculata has been shown to possess hypolipidemic effects in animals .", "sentence_id": 1}
+{"abstract_id": "26434249", "label": "objective", "text": "To investigate the TG-lowering effects of A. paniculata extract ( APE ) in patients with hypertriglyceridemia ( TG @ mg/dL ) using gemfibrozil treatment as the reference .", "sentence_id": 2}
+{"abstract_id": "26434249", "label": "methods", "text": "A randomized controlled clinical trial was carried out in sixty subjects with hypertriglyceridemia .", "sentence_id": 3}
+{"abstract_id": "26434249", "label": "methods", "text": "They were divided into three groups and treated with low dose of APE ( APE-L , andrographolide @-@ @ mg/day ) , high dose of APE ( APE-H , andrographolide @-@ @ mg/day ) , and gemfibrozil @ mg/day .", "sentence_id": 4}
+{"abstract_id": "26434249", "label": "methods", "text": "The treatments were conducted for @ weeks .", "sentence_id": 5}
+{"abstract_id": "26434249", "label": "methods", "text": "Guidance on lifestyle modifications was provided .", "sentence_id": 6}
+{"abstract_id": "26434249", "label": "results", "text": "The primary endpoint was the mean difference SD ( @ % CI ) in TG levels ( baseline from the end of treatment ) , which were -@ @ ( -@ , @ ) , @ @ ( @ , @ ) , and @ @ ( @ , @ ) in the APE-L , APE-H , and gemfibrozil groups , respectively .", "sentence_id": 7}
+{"abstract_id": "26434249", "label": "results", "text": "APE-H @ mg/day and gemfibrozil @ mg/day caused a significant reduction of TG level ( P = @ and @ , respectively ) when compared to the baseline .", "sentence_id": 8}
+{"abstract_id": "26434249", "label": "results", "text": "There was no notable difference in the safety or tolerability among the treatment groups .", "sentence_id": 9}
+{"abstract_id": "26434249", "label": "conclusions", "text": "In patients with modest hypertriglyceridemia with lifestyle intervention , APE-H reduced the TG level comparable to the effect of gemfibrozil @ mg/day .", "sentence_id": 10}
+{"abstract_id": "26434249", "label": "conclusions", "text": "APE treatment was as tolerable as gemfibrozil treatment .", "sentence_id": 11}
+{"abstract_id": "26434249", "label": "conclusions", "text": "Hence , Andrographis paniculata might be used as an alternative medicine in treating hypertriglyceridemic patients .", "sentence_id": 12}
+{"abstract_id": "24286456", "label": "background", "text": "Several chemokines , notably eotaxin , mediate the recruitment of eosinophils into tissues via the CCR@ receptor .", "sentence_id": 0}
+{"abstract_id": "24286456", "label": "objective", "text": "In this study , we investigated the role of CCR@ agonists in asthma by observing the effect of a small molecule antagonist of the CCR@ receptor ( GW@ ) on sputum eosinophil counts in patients with eosinophilic asthma .", "sentence_id": 1}
+{"abstract_id": "24286456", "label": "methods", "text": "Clinical and physiological outcomes , the chemotactic activity of sputum supernatant for eosinophils and the presence of eosinophil progenitors in sputum and blood samples were also studied .", "sentence_id": 2}
+{"abstract_id": "24286456", "label": "results", "text": "In a double-blind parallel group study , @ patients with asthma were randomized to @ mg of GW@ twice daily or matching placebo for @ days followed by prednisone @ mg for @ days .", "sentence_id": 3}
+{"abstract_id": "24286456", "label": "results", "text": "Of these patients , @ had a sputum eosinophil count > @ % at baseline .", "sentence_id": 4}
+{"abstract_id": "24286456", "label": "results", "text": "Despite plasma concentrations of drug consistent with > @ % receptor occupancy during the dosing period , the CCR@ antagonist did not significantly reduce eosinophils or eosinophil progenitor cells ( CD@ ( + ) @ ( + ) IL-@R ( + ) ) in sputum or in blood .", "sentence_id": 5}
+{"abstract_id": "24286456", "label": "results", "text": "The ex vivo chemotactic effect of sputum supernatants on eosinophils was attenuated by GW@ compared to placebo .", "sentence_id": 6}
+{"abstract_id": "24286456", "label": "results", "text": "There was no improvement in FEV@ ; however , there was a modest but statistically significant improvement in PC@ methacholine ( @ doubling dose ) and ACQ scores , ( @ ) .", "sentence_id": 7}
+{"abstract_id": "24286456", "label": "results", "text": "Whilst the improvement in PC@ is statistically significant , it is not of clinical significance .", "sentence_id": 8}
+{"abstract_id": "24286456", "label": "conclusions", "text": "In conclusion , this study calls into question the role of CCR@ in airway eosinophilia in asthma and suggests that other cellular mechanisms mediated by the CCR@ receptor may contribute to airway hyperresponsiveness .", "sentence_id": 9}
+{"abstract_id": "24689456", "label": "background", "text": "Current evidence suggests that many patients with self-reported non-coeliac gluten sensitivity ( NCGS ) retain gastrointestinal symptoms on a gluten-free diet ( GFD ) but continue to restrict gluten as they report ` feeling better ' .", "sentence_id": 0}
+{"abstract_id": "24689456", "label": "objective", "text": "To investigate the notion that a major effect of gluten in those with NCGS is on mental state and not necessarily on gastrointestinal symptoms .", "sentence_id": 1}
+{"abstract_id": "24689456", "label": "methods", "text": "Twenty-two subjects ( @-@ years , five male ) with irritable bowel syndrome who had coeliac disease excluded but were symptomatically controlled on a GFD , undertook a double-blind cross-over study .", "sentence_id": 2}
+{"abstract_id": "24689456", "label": "methods", "text": "Participants randomly received one of three dietary challenges for @ days , followed by a minimum @-day washout before crossing over to the next diet .", "sentence_id": 3}
+{"abstract_id": "24689456", "label": "methods", "text": "Challenge gluten-free food was supplemented with gluten ( @ g/day ) , whey ( @ g/day ) or not supplemented ( placebo ) .", "sentence_id": 4}
+{"abstract_id": "24689456", "label": "methods", "text": "End-points included mental state as assessed by the Spielberger State Trait Personality Inventory ( STPI ) , cortisol secretion and gastrointestinal symptoms .", "sentence_id": 5}
+{"abstract_id": "24689456", "label": "results", "text": "Gluten ingestion was associated with higher overall STPI state depression scores compared to placebo -LSB- M = @ , @ % CI ( @-@ @ ) , P = @ -RSB- but not whey -LSB- M = @ , @ % CI ( -@ to @ ) , P = @ -RSB- .", "sentence_id": 6}
+{"abstract_id": "24689456", "label": "results", "text": "No differences were found for other STPI state indices or for any STPI trait measures .", "sentence_id": 7}
+{"abstract_id": "24689456", "label": "results", "text": "No difference in cortisol secretion was identified between challenges .", "sentence_id": 8}
+{"abstract_id": "24689456", "label": "results", "text": "Gastrointestinal symptoms were induced similarly across all dietary challenges .", "sentence_id": 9}
+{"abstract_id": "24689456", "label": "conclusions", "text": "Short-term exposure to gluten specifically induced current feelings of depression with no effect on other indices or on emotional disposition .", "sentence_id": 10}
+{"abstract_id": "24689456", "label": "conclusions", "text": "Gluten-specific induction of gastrointestinal symptoms was not identified .", "sentence_id": 11}
+{"abstract_id": "24689456", "label": "conclusions", "text": "Such findings might explain why patients with non-coeliac gluten sensitivity feel better on a gluten-free diet despite the continuation of gastrointestinal symptoms .", "sentence_id": 12}
+{"abstract_id": "24554074", "label": "objective", "text": "Concomitant carotid and cardiac surgery carries an increased perioperative morbidity and mortality risk .", "sentence_id": 0}
+{"abstract_id": "24554074", "label": "objective", "text": "Whether the hybrid procedure of carotid artery stenting ( CAS ) and coronary bypass surgery decreases the risk of stroke and other complications is still unknown .", "sentence_id": 1}
+{"abstract_id": "24554074", "label": "objective", "text": "The aim of this study was to assess early outcomes after simultaneous hybrid CAS and coronary bypass grafting versus open concomitant carotid and coronary bypass surgery .", "sentence_id": 2}
+{"abstract_id": "24554074", "label": "methods", "text": "We included @ patients in this study .", "sentence_id": 3}
+{"abstract_id": "24554074", "label": "methods", "text": "According to the protocol , all the patients were divided into two groups : Group @ ( @ patients ) with hybrid CAS and coronary bypass surgery and Group @ ( @ patients ) with concomitant carotid and coronary surgery .", "sentence_id": 4}
+{"abstract_id": "24554074", "label": "methods", "text": "Different preoperative , intraoperative and postoperative variables were compared .", "sentence_id": 5}
+{"abstract_id": "24554074", "label": "methods", "text": "The primary end point was combined incidence of stroke and death @ days after surgery or during initial hospitalization .", "sentence_id": 6}
+{"abstract_id": "24554074", "label": "methods", "text": "The secondary end points were myocardial infarction , atrial fibrillation , blood loss and need for blood transfusion and duration of intensive care unit and hospital stay .", "sentence_id": 7}
+{"abstract_id": "24554074", "label": "results", "text": "Groups @ and @ were similar in preoperative characteristics including age ( @ @ vs @ @ , P = @ ) New York Heart Association class ( @ @ vs @ @ , P = @ ) , EuroSCORE ( @ @ vs @ @ , P = @ ) , the degree of carotid stenosis ( @ @ vs @ @ % , P = @ ) and average left ventricular ejection fraction ( @ @ vs @ @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24554074", "label": "results", "text": "Also , the groups did not differ in intraoperative variables with an exception of extracorporeal circulation time ( @ @ vs @ + @ min , P = @ ) , which was significantly shorter in Group @ .", "sentence_id": 9}
+{"abstract_id": "24554074", "label": "results", "text": "Although rare , and without significant difference , primary end point occurred only in Group @ ( @ stroke and @ death , @ % ) .", "sentence_id": 10}
+{"abstract_id": "24554074", "label": "results", "text": "There was no difference in the duration of mechanical ventilation , need for transfusion and duration of intensive care unit and hospital stay between the two groups .", "sentence_id": 11}
+{"abstract_id": "24554074", "label": "conclusions", "text": "Although limited by a small sample size , our results show that the hybrid procedure of carotid stenting and coronary surgery might be a good therapeutic option but further extended studies are needed to assess its real value .", "sentence_id": 12}
+{"abstract_id": "25265151", "label": "background", "text": "Reduced estimated glomerular filtration rate ( eGFR ) using the cystatin-C derived equations might be a better predictor of cardiovascular disease ( CVD ) mortality compared with the creatinine-derived equations , but this association remains unclear in elderly individuals .", "sentence_id": 0}
+{"abstract_id": "25265151", "label": "objective", "text": "The aims of this study were to compare the predictive values of the Chronic Kidney Disease Epidemiology Collaboration ( CKD-EPI ) - creatinine , CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C eGFR equations for all-cause mortality and CVD events ( hospitalizationsmortality ) .", "sentence_id": 1}
+{"abstract_id": "25265151", "label": "methods", "text": "Prospective cohort study of @ elderly women aged > @ years .", "sentence_id": 2}
+{"abstract_id": "25265151", "label": "methods", "text": "Associations between eGFR and outcomes were examined using Cox regression analysis .", "sentence_id": 3}
+{"abstract_id": "25265151", "label": "methods", "text": "Test accuracy of eGFR equations for predicting outcomes was examined using Receiver Operating Characteristic ( ROC ) analysis and net reclassification improvement ( NRI ) .", "sentence_id": 4}
+{"abstract_id": "25265151", "label": "results", "text": "Risk of all-cause mortality for every incremental reduction in eGFR determined using CKD-EPI-creatinine , CKD-EPI-cystatin C and the CKD-EPI-creatinine-cystatic C equations was similar .", "sentence_id": 5}
+{"abstract_id": "25265151", "label": "results", "text": "Areas under the ROC curves of CKD-EPI-creatinine , CKD-EPI-cystatin C and CKD-EPI-creatinine-cystatin C equations for all-cause mortality were @ ( @ % CI @-@ @ ) , @ ( @ % CI @-@ @ ; p = @ ) and @ ( @ % CI @-@ @ ; p = @ ) respectively .", "sentence_id": 6}
+{"abstract_id": "25265151", "label": "results", "text": "For all-cause mortality , there was no improvement in the reclassification of eGFR categories using the CKD-EPI-cystatin C ( NRI -@ % ; p = @ ) and CKD-EPI-creatinine-cystatin C ( NRI -@ % ; p = @ ) compared with CKD-EPI-creatinine equation .", "sentence_id": 7}
+{"abstract_id": "25265151", "label": "results", "text": "Similar findings were observed for CVD events .", "sentence_id": 8}
+{"abstract_id": "25265151", "label": "conclusions", "text": "eGFR derived from CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C equations did not improve the accuracy or predictive ability for clinical events compared to CKD-EPI-creatinine equation in this cohort of elderly women .", "sentence_id": 9}
+{"abstract_id": "24405492", "label": "background", "text": "The ASPIRE in-clinic study established that automatic suspension of insulin with the threshold suspend ( TS ) feature reduces the duration of induced hypoglycemia .", "sentence_id": 0}
+{"abstract_id": "24405492", "label": "background", "text": "The study 's crossover design allowed the effects of antecedent hypoglycemia to be studied .", "sentence_id": 1}
+{"abstract_id": "24405492", "label": "methods", "text": "The study enrolled @ subjects who exercised until plasma glucose ( YSI glucose and lactate analyzer ; YSI , Inc. , Yellow Springs , OH ) reached @ mg/dL .", "sentence_id": 2}
+{"abstract_id": "24405492", "label": "methods", "text": "Hypoglycemia was evaluated after the YSI value reached < @ mg/dL .", "sentence_id": 3}
+{"abstract_id": "24405492", "label": "methods", "text": "In TS experiments , insulin was stopped for @ h once a sensor glucose ( SG ) value of @ mg/dL was detected ; in control experiments , basal insulin delivery continued .", "sentence_id": 4}
+{"abstract_id": "24405492", "label": "methods", "text": "Subjects were randomly assigned to Group A ( TS in Period @ ; control in Period @ ) or Group B ( control in Period @ ; TS in Period @ ) .", "sentence_id": 5}
+{"abstract_id": "24405492", "label": "methods", "text": "Experiments were separated by @-@ days .", "sentence_id": 6}
+{"abstract_id": "24405492", "label": "results", "text": "Hypoglycemia was @ min shorter in Period @ TS experiments ( no preceding control experiment ) than in Period @ TS experiments ( one or more preceding control experiment ( s ) ) ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24405492", "label": "results", "text": "The number of experiments prior to a successful TS experiment was lower for Period @ than for Period @ ( @ @ vs. @ @ ; P < @ ) , as was the cumulative duration of antecedent hypoglycemia ( @ min vs. @ min ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24405492", "label": "results", "text": "The between-groups difference in hypoglycemia duration was not attributable to differences in SG rates of change , the duration of exercise , or area under the curve of < @ mg/dL min in the @ days before the successful experiment ( all P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24405492", "label": "conclusions", "text": "The TS feature 's ability to mitigate hypoglycemia was decreased by an episode or episodes of prolonged antecedent hypoglycemia , suggesting hypoglycemia begets hypoglycemia .", "sentence_id": 10}
+{"abstract_id": "24405492", "label": "conclusions", "text": "The effect of antecedent hypoglycemia should be taken into consideration in the design of future experiments assessing strategies to reduce hypoglycemia .", "sentence_id": 11}
+{"abstract_id": "24660647", "label": "objective", "text": "Low-level laser therapy has still not been well established , and it is important to define a standardized protocol for the treatment of temporomandibular disorders ( TMDs ) using low level laser .", "sentence_id": 0}
+{"abstract_id": "24660647", "label": "objective", "text": "There is no consensus on controlled clinical trials concerning the best option for laser therapy with regard to wavelength .", "sentence_id": 1}
+{"abstract_id": "24660647", "label": "objective", "text": "The aim of this study was to evaluate the efficacy of red and infrared laser therapy in patients with TMD , using a randomized parallel-group double-blind trial .", "sentence_id": 2}
+{"abstract_id": "24660647", "label": "methods", "text": "Each hemiface of @ subjects was randomized to receive intervention , in a total of @ sensitive points .", "sentence_id": 3}
+{"abstract_id": "24660647", "label": "methods", "text": "Pain was measured at baseline and time intervals of @ hours , @ days , @ days , and @ days after treatment .", "sentence_id": 4}
+{"abstract_id": "24660647", "label": "methods", "text": "Irradiation of @ J/cm@ in the temporomandibular joints and @ J/cm ( @ ) in the muscles was used in three sessions .", "sentence_id": 5}
+{"abstract_id": "24660647", "label": "results", "text": "Both treatments had statistically significant results ( P < @ ) ; there was statistical difference between them at @ days in favor of the infrared laser ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24660647", "label": "results", "text": "There was improvement in @ hours , which extended up to @ days in both groups .", "sentence_id": 7}
+{"abstract_id": "24660647", "label": "conclusions", "text": "Both lasers are effective in the treatment and remission of TMD symptoms .", "sentence_id": 8}
+{"abstract_id": "25432000", "label": "objective", "text": "Extensive discussion with renal patients about treatment intensity is not systematically integrated into their care and often occurs during an acute hospitalization .", "sentence_id": 0}
+{"abstract_id": "25432000", "label": "objective", "text": "We conducted a `` test-of-change '' pilot study to assess the utility of providing an upstream discussion in the ambulatory setting as an additional nephrology consult to assist patients with chronic kidney disease considering treatment choices .", "sentence_id": 1}
+{"abstract_id": "25432000", "label": "methods", "text": "We randomly assigned patients with Stage @ or Stage @ chronic kidney disease who had not yet begun renal dialysis to @ of @ groups .", "sentence_id": 2}
+{"abstract_id": "25432000", "label": "methods", "text": "The test group received the additional nephrology consult and met with an interdisciplinary team composed of a nephrologist , social worker , and clinical ethicist , and the control group did not .", "sentence_id": 3}
+{"abstract_id": "25432000", "label": "methods", "text": "Qualitative data were collected in @ and @ via oral questionnaire .", "sentence_id": 4}
+{"abstract_id": "25432000", "label": "methods", "text": "Both groups received a @-month follow-up assessment .", "sentence_id": 5}
+{"abstract_id": "25432000", "label": "results", "text": "Patients who received the nephrology consult reported that they experienced help in forming a treatment plan , felt well understood , and had the opportunity to thoroughly discuss questions .", "sentence_id": 6}
+{"abstract_id": "25432000", "label": "results", "text": "The controls had a @ % increased probability of beginning dialysis and had a statistically significant increase in dialysis and clinic visits ( p < @ and p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25432000", "label": "results", "text": "Controls also were likelier than the test group to be admitted to the hospital ( @ vs @ admissions per patient in the test group ) , spend more days hospitalized ( @ vs @ bed days per patient ) , and visit the emergency room ( @ vs @ visits per patient ) and clinic ( @ vs @ visits per patient ) .", "sentence_id": 8}
+{"abstract_id": "25432000", "label": "conclusions", "text": "An additional nephrology consultation proved helpful both qualitatively and quantitatively .", "sentence_id": 9}
+{"abstract_id": "24501162", "label": "background", "text": "The metabolic syndrome is the most important risk factor for cardiovascular disease .", "sentence_id": 0}
+{"abstract_id": "24501162", "label": "background", "text": "The heat shock proteins ( HSPs ) are highly conserved families of proteins expressed by a number of cell types following exposure to stressful environmental conditions include several known risk factors for cardiovascular disease .", "sentence_id": 1}
+{"abstract_id": "24501162", "label": "background", "text": "Recent studies have shown the potential of constituents of saffron in the treatment of atherosclerosis .", "sentence_id": 2}
+{"abstract_id": "24501162", "label": "background", "text": "We aimed on investigating the effect of saffron on antibody titers to HSP in patients with metabolic syndrome .", "sentence_id": 3}
+{"abstract_id": "24501162", "label": "methods", "text": "This was a randomized , placebo-controlled clinical trial .", "sentence_id": 4}
+{"abstract_id": "24501162", "label": "methods", "text": "One-hundred and five subjects with metabolic syndrome were randomly allocated to one of the three groups : the case group received @ mg/day saffron , the placebo control group received a capsule of placebo and a non-placebo control group received no capsule , for @ weeks .", "sentence_id": 5}
+{"abstract_id": "24501162", "label": "results", "text": "Antibodies against heat shock proteins @ , @ , @ and @ were determined in all patients before ( week @ ) and after ( week @ and @ ) intervention .", "sentence_id": 6}
+{"abstract_id": "24501162", "label": "results", "text": "At @ weeks , saffron produced a significantly decrease in AntiHSP@ , @ levels .", "sentence_id": 7}
+{"abstract_id": "24501162", "label": "results", "text": "Saffron can decrease AntiHSP@ , @ levels in patients with metabolic syndrome .", "sentence_id": 8}
+{"abstract_id": "24501162", "label": "conclusions", "text": "The results of this study indicate the efficacy of saffron in the improvement of some markers of autoimmunity HSPs in patients with metabolic syndrome .", "sentence_id": 9}
+{"abstract_id": "25302772", "label": "objective", "text": "The objective of this longitudinal study was to determine what typical vitamin D predictors influence the change in vitamin D status from mid-pregnancy to birth .", "sentence_id": 0}
+{"abstract_id": "25302772", "label": "methods", "text": "Plasma @-hydroxyvitamin D -LSB- @ ( OH ) D -RSB- was determined at mid-pregnancy ( @-@ weeks gestation ) and following birth ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25302772", "label": "methods", "text": "Usual predictors of vitamin D status -LSB- body mass index ( BMI ) , race , season -RSB- in addition to prenatal supplemental vitamin D intake and docosahexaenoic acid ( DHA ) status at delivery were assessed for their interaction on the change on plasma @ ( OH ) D concentration between the two time points .", "sentence_id": 2}
+{"abstract_id": "25302772", "label": "results", "text": "Forty-nine percent of women had inadequate vitamin D status -LSB- categorized as deficient ( < @ nmol/L ) or insufficient ( @-@ @ nmol/L ) by IOM guidelines -RSB- at mid-pregnancy and @ % were deficient or insufficient at birth .", "sentence_id": 3}
+{"abstract_id": "25302772", "label": "results", "text": "Plasma @ ( OH ) D concentration dropped @ % from mid-pregnancy to birth .", "sentence_id": 4}
+{"abstract_id": "25302772", "label": "results", "text": "Season of birth ( F = @ , P = @ ) and mid-pregnancy plasma @ ( OH ) D concentration ( F = @ , P = @ ) were significant variables in the change of vitamin D status while BMI , race , DHA status , and typical vitamin D intake ( @ IU/day ) from prenatal supplements did not have an effect .", "sentence_id": 5}
+{"abstract_id": "25302772", "label": "results", "text": "Women who delivered in summer and fall had a @-fold greater plasma @ ( OH ) D concentration than women who delivered in winter in spring ( @ @ and @ @ nmol/L summer and fall , respectively , versus @ @ and @ @ nmol/L in winter and spring , respectively ) .", "sentence_id": 6}
+{"abstract_id": "25302772", "label": "conclusions", "text": "Typical supplemental vitamin D intake during pregnancy did not prevent precipitous drops in maternal plasma @ ( OH ) D concentration .", "sentence_id": 7}
+{"abstract_id": "25302772", "label": "conclusions", "text": "Clinicians and dietitians should be aware of the risk of inadequate vitamin D status in pregnant women in the United States relative to their initial vitamin D status and the season of birth .", "sentence_id": 8}
+{"abstract_id": "24284856", "label": "background", "text": "Osteoarthritis is a common condition , typically treated with orally administered analgesics and non-steroidal anti-inflammatory drugs ( NSAIDs ) .", "sentence_id": 0}
+{"abstract_id": "24284856", "label": "background", "text": "Chronic administration of NSAIDs , serotonin-norepinephrine reuptake inhibitors ( SNRIs , i.e. , duloxetine ) , and opioid medications ( i.e. , tramadol ) is regularly associated with multiple , serious side effects , in part due to the route of administration .", "sentence_id": 1}
+{"abstract_id": "24284856", "label": "background", "text": "Transdermal delivery of NSAIDs , such as ibuprofen , represents a potentially alternative treatment for this inflammatory pain condition with a better therapeutic profile .", "sentence_id": 2}
+{"abstract_id": "24284856", "label": "objective", "text": "Investigate the safety and efficacy of a novel transdermal ibuprofen formulation ( VALE-ibuprofen ) containing @ % ibuprofen , compared to a placebo in a randomized , double-blinded clinical trial , for clinical improvement in patients with moderate to severe painful osteoarthritis of the knee .", "sentence_id": 3}
+{"abstract_id": "24284856", "label": "methods", "text": "A randomized , placebo-controlled , double blind , multi-center Phase @ clinical trial .", "sentence_id": 4}
+{"abstract_id": "24284856", "label": "methods", "text": "An academic medical center , and private rheumatology and interventional pain management practices .", "sentence_id": 5}
+{"abstract_id": "24284856", "label": "methods", "text": "The Phase @ clinical study included patients with primary osteoarthritis in a single knee joint with a progression level of moderate to severe based in part on a grade II or III designation according to the Kellgren and Lawrence classification system .", "sentence_id": 6}
+{"abstract_id": "24284856", "label": "methods", "text": "Patients received the corresponding , randomly assigned study formulation ( VALE-ibuprofen or placebo ) for application to the target knee at a dose of @ grams of drug product ( @ mg ibuprofen ) twice daily for @ days .", "sentence_id": 7}
+{"abstract_id": "24284856", "label": "methods", "text": "The evaluation of the efficacy of the treatments utilized the widely accepted methods of the Western Ontario and McMaster Universities ( WOMAC ) Osteoarthritis Index and the Visual Analog Scale ( VAS ) scores for the patients .", "sentence_id": 8}
+{"abstract_id": "24284856", "label": "results", "text": "The results indicate that the transdermal VALE-ibuprofen formulation was very well tolerated from a safety perspective during the @-week trial and also produced significant , positive clinical improvements superior to the placebo in all clinical endpoints tested .", "sentence_id": 9}
+{"abstract_id": "24284856", "label": "results", "text": "In particular , the WOMACTotal and WOMACPhysical Functioning , for the VALE-ibuprofen , were superior compared to the placebo ( P = @ and P = @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "24284856", "label": "results", "text": "Other clinical endpoints including the WOMACPain , WOMACStiffness , and VASResting scores were superior to those obtained from the placebo group , trending towards statistical significance compared to placebo ( P = @ , @ , and @ , respectively ) .", "sentence_id": 11}
+{"abstract_id": "24284856", "label": "results", "text": "Based on the Patient and Physician Global Impression of Change survey , patient satisfaction slightly improved across both groups ; however , no statistical significance was detectable as compared to the baseline .", "sentence_id": 12}
+{"abstract_id": "24284856", "label": "conclusions", "text": "The sample size of @ subjects in the final data analysis and the lack of including an orally administered drug group are limitations of this study .", "sentence_id": 13}
+{"abstract_id": "24284856", "label": "conclusions", "text": "The use of transdermal VALE-ibuprofen has beneficial clinical effects on the pain levels experienced in some patients with moderate to severe osteoarthritis of the knee as measured by the WOMAC Osteoarthritis Indices for stiffness , pain , physical function , and total .", "sentence_id": 14}
+{"abstract_id": "24284856", "label": "conclusions", "text": "Visual Analog Scales ( VAS ) tests , VASMotion and VASWeight-bearing , again while appeared superior to placebo , were not statistically different from placebo .", "sentence_id": 15}
+{"abstract_id": "24874481", "label": "background", "text": "Invasion and metastasis remain a critical issue in cervical cancer .", "sentence_id": 0}
+{"abstract_id": "24874481", "label": "background", "text": "However , the underlying mechanism of it in cervical cancer remains unclear .", "sentence_id": 1}
+{"abstract_id": "24874481", "label": "background", "text": "The newly discovered protein , TBLR@ , plays a crucial role in regulating various key cellular functions .", "sentence_id": 2}
+{"abstract_id": "24874481", "label": "methods", "text": "In this study , western blot , real-time RT-PCR , immunohistochemical staining , @D morphogenesis Matrigel culture , wound healing and Boyden chamber invasion assays , xenografted tumour model , luciferase assays , and chromatin immunoprecipitation assays were used .", "sentence_id": 3}
+{"abstract_id": "24874481", "label": "results", "text": "The expression of TBLR@ in cervical cancer cell lines and tissues was significantly upregulated at both the RNA and protein levels compared with that in normal cervical cells .", "sentence_id": 4}
+{"abstract_id": "24874481", "label": "results", "text": "Statistical analysis suggested that TBLR@ as an independent prognostic factor was significantly correlated with the clinical stage , survival time and recurrence .", "sentence_id": 5}
+{"abstract_id": "24874481", "label": "results", "text": "Moreover , overexpression of TBLR@ in Hela and Siha cell lines promoted invasion in vitro and in vivo with the increases of the mesenchymal factors vimentin and fibronectin and decreases of the epithelial marker - catenin .", "sentence_id": 6}
+{"abstract_id": "24874481", "label": "results", "text": "In contrast , RNAi-mediated knockdown of TBLR@ inhibited epithelial-mesenchymal transition in vitro and in vivo .", "sentence_id": 7}
+{"abstract_id": "24874481", "label": "results", "text": "Further study indicated that this might be mediated via the NF-B and Wnt / - Catenin signalling pathway , and involve regulation of Snail and Twist .", "sentence_id": 8}
+{"abstract_id": "24874481", "label": "conclusions", "text": "The TBLR@ protein may be a prognostic marker in cervical cancer and play an important role in the invasion and metastasis of human cervical cancer .", "sentence_id": 9}
+{"abstract_id": "26158926", "label": "objective", "text": "To compare aqueous humor pH values in patients during femtosecond laser-assisted cataract surgery with patients during conventional phacoemulsification .", "sentence_id": 0}
+{"abstract_id": "26158926", "label": "methods", "text": "A prospective clinical study was conducted in @ eyes of @ patients who underwent cataract surgery by a single surgeon .", "sentence_id": 1}
+{"abstract_id": "26158926", "label": "methods", "text": "The femtosecond laser group included @ eyes operated on with a femtosecond laser platform ( Catalys ; Abbott Medical Optics , Santa Ana , CA ) and the phacoemulsification group included @ eyes that were operated on with conventional phacoemulsification .", "sentence_id": 2}
+{"abstract_id": "26158926", "label": "methods", "text": "The femtosecond laser group was subdivided into low , medium , and high level of cavitation gas bubbles after docking and the femtosecond laser procedure , according to the judgment of the surgeon .", "sentence_id": 3}
+{"abstract_id": "26158926", "label": "methods", "text": "Aqueous humor samples ( @ to @ mL ) were collected through a paracentesis from each patient after docking , corneal incisions , and nucleus fragmentation in the femtosecond laser group and after corneal incisions but before injection of viscoelastic in the phacoemulsification group , then analyzed with a pH meter .", "sentence_id": 4}
+{"abstract_id": "26158926", "label": "results", "text": "The mean pH was @ @ ( range : @ to @ ) and @ @ ( range : @ to @ ) in the femtosecond laser and phacoemulsification groups , respectively ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "26158926", "label": "results", "text": "In the femtosecond laser group , no significant differences in pH were observed between the three subgroups after docking and the femtosecond laser surgical procedure : low ( @ @ -LSB- range : @ to @ -RSB- ) , medium ( @ @ -LSB- range : @ to @ -RSB- ) , and high ( @ @ -LSB- range : @ to @ -RSB- ) level of gas bubbles .", "sentence_id": 6}
+{"abstract_id": "26158926", "label": "conclusions", "text": "Cavitation bubbles derived from the photodisruption process in femtosecond laser-assisted cataract surgery lead to an acidic shift of the aqueous humor pH as a result of the transformation of carbon dioxide to carbonic acid .", "sentence_id": 7}
+{"abstract_id": "26158926", "label": "conclusions", "text": "The level of gas bubbles visible after the laser photodisruption does not seem to correlate with this pH shift .", "sentence_id": 8}
+{"abstract_id": "26158926", "label": "conclusions", "text": "Further analysis of femtosecond laser-assisted cataract surgery is necessary .", "sentence_id": 9}
+{"abstract_id": "25398689", "label": "background", "text": "Long-acting @-adrenergic agonists ( LABAs ) are recommended in combination with inhaled corticosteroids ( ICSs ) for asthma management .", "sentence_id": 0}
+{"abstract_id": "25398689", "label": "background", "text": "Abediterol is a novel , selective , potent , once-daily LABA in development for treatment of asthma and chronic obstructive pulmonary disease .", "sentence_id": 1}
+{"abstract_id": "25398689", "label": "background", "text": "This study aimed to determine abediterol doses with similar peak bronchodilatory effect to salbutamol @ g , and duration of action compatible with once-daily dosing in patients with persistent , stable asthma .", "sentence_id": 2}
+{"abstract_id": "25398689", "label": "methods", "text": "This was a Phase II , randomized , double-blind , double-dummy , crossover , placebo-controlled , dose-ranging study ( ClinicalTrials.gov NCT@ ) in @ patients with mild-to-moderate asthma who were also receiving an ICS .", "sentence_id": 3}
+{"abstract_id": "25398689", "label": "methods", "text": "Patients received single doses of abediterol @ , @ , @ , or @ g , salbutamol @ g , or placebo in the morning .", "sentence_id": 4}
+{"abstract_id": "25398689", "label": "methods", "text": "Spirometry was performed up to @ h post-dose ; safety and tolerability were assessed throughout the study .", "sentence_id": 5}
+{"abstract_id": "25398689", "label": "methods", "text": "The primary endpoint was change from baseline in peak forced expiratory volume in @ s ( FEV@ ) .", "sentence_id": 6}
+{"abstract_id": "25398689", "label": "methods", "text": "Additional endpoints included trough FEV@ , normalized area under the FEV@ curve ( FEV@ AUC ) up to @ h post-dose , and peak and trough forced vital capacity ( FVC ) .", "sentence_id": 7}
+{"abstract_id": "25398689", "label": "results", "text": "Abediterol produced dose-dependent improvements in peak FEV@ from baseline compared with placebo , from @ ( @ % CI @ , @ ) to @ L ( @ % CI @ , @ ) for abediterol @ to @ g , respectively ( p < @ all doses ) .", "sentence_id": 8}
+{"abstract_id": "25398689", "label": "results", "text": "Abediterol @ , @ , and @ g had similar magnitude of peak FEV@ effect to salbutamol .", "sentence_id": 9}
+{"abstract_id": "25398689", "label": "results", "text": "Dose-dependent changes from baseline in trough FEV@ versus placebo were @ ( @ % CI @ , @ ) to @ L ( @ % CI @ , @ ) for abediterol @ to @ g , respectively ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25398689", "label": "results", "text": "All abediterol doses achieved significant improvements versus placebo in FEV@ AUC @-@ , @-@ , and @-@ h , and peak and trough FVC ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "25398689", "label": "results", "text": "Less than @ % of patients experienced treatment-related adverse events for each dose of abediterol ; most were mild to moderate in intensity and the most common were headache and nasopharyngitis .", "sentence_id": 12}
+{"abstract_id": "25398689", "label": "results", "text": "There were no clinically relevant changes in heart rate .", "sentence_id": 13}
+{"abstract_id": "25398689", "label": "conclusions", "text": "Abediterol @-@ @ g provided dose-dependent , clinically and statistically significant bronchodilation versus placebo in patients with asthma , with a peak effect similar to salbutamol and duration of action compatible with once-daily dosing .", "sentence_id": 14}
+{"abstract_id": "25398689", "label": "conclusions", "text": "All doses of abediterol were well tolerated .", "sentence_id": 15}
+{"abstract_id": "25512675", "label": "objective", "text": "To identify the first time point of an MRI-verified response to certolizumab pegol ( CZP ) therapy in patients with rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "25512675", "label": "methods", "text": "Forty-one patients with active RA despite disease-modifying antirheumatic drug therapy were randomised @:@ to CZP ( CZP loading dose @mg every @weeksat weeks @-@ ; CZP @mg every @weeksat weeks @-@ ) or placeboCZP ( placebo at weeks @-@ ; CZP loading dose at weeks @-@ ; CZP @mg every @weeks at weeks @-@ ) .", "sentence_id": 1}
+{"abstract_id": "25512675", "label": "methods", "text": "Contrast-enhanced MRI of one hand and wrist was acquired at baseline ( week @ ) and weeks @ , @ , @ , @ and @ .", "sentence_id": 2}
+{"abstract_id": "25512675", "label": "methods", "text": "All six time points were read simultaneously , blinded to time , using the Outcome Measures in Rheumatology Clinical Trials RA MRI scoring system .", "sentence_id": 3}
+{"abstract_id": "25512675", "label": "methods", "text": "Primary outcome was change in synovitis score in the CZP group ; secondary outcomes were change in bone oedema ( osteitis ) and erosion scores and clinical outcome measures .", "sentence_id": 4}
+{"abstract_id": "25512675", "label": "results", "text": "Forty patients were treated ( @ CZP , @ placeboCZP ) , and @ ( @ CZP , @ placeboCZP ) completed week @ .", "sentence_id": 5}
+{"abstract_id": "25512675", "label": "results", "text": "In the CZP group , there were significant reductions from baseline synovitis ( Hodges-Lehmann estimate of median change , -@ , p = @ ) and osteitis scores ( -@ , p = @ ) at week @ .", "sentence_id": 6}
+{"abstract_id": "25512675", "label": "results", "text": "Numerical , but statistically insignificant , MRI inflammation reductions were observed at weeks @-@ in the CZP group .", "sentence_id": 7}
+{"abstract_id": "25512675", "label": "results", "text": "No significant change was seen in bone erosion score .", "sentence_id": 8}
+{"abstract_id": "25512675", "label": "results", "text": "Improvements across all clinical outcomes were seen in the CZP group .", "sentence_id": 9}
+{"abstract_id": "25512675", "label": "conclusions", "text": "CZP reduced MRI synovitis and osteitis scores at week @ , despite small sample size and the technical challenge of reading six time points simultaneously .", "sentence_id": 10}
+{"abstract_id": "25512675", "label": "conclusions", "text": "This study provides essential information on optimal MRI timing for subsequent trials .", "sentence_id": 11}
+{"abstract_id": "24780501", "label": "objective", "text": "High-density lipoproteins ( HDLs ) have several potentially protective vascular effects .", "sentence_id": 0}
+{"abstract_id": "24780501", "label": "objective", "text": "Most clinical studies of therapies targeting HDL have failed to show benefits vs. placebo .", "sentence_id": 1}
+{"abstract_id": "24780501", "label": "objective", "text": "To investigate the effects of an HDL-mimetic agent on atherosclerosis by intravascular ultrasonography ( IVUS ) and quantitative coronary angiography ( QCA ) .", "sentence_id": 2}
+{"abstract_id": "24780501", "label": "methods", "text": "A prospective , double-blinded , randomized trial was conducted at @ centres in the USA , the Netherlands , Canada , and France .", "sentence_id": 3}
+{"abstract_id": "24780501", "label": "methods", "text": "Intravascular ultrasonography and QCA were performed to assess coronary atherosclerosis at baseline and @ ( @-@ ) weeks after the last study infusion .", "sentence_id": 4}
+{"abstract_id": "24780501", "label": "methods", "text": "Five hundred and seven patients were randomized ; @ and @ had paired IVUS and QCA measurements , respectively .", "sentence_id": 5}
+{"abstract_id": "24780501", "label": "methods", "text": "Patients were randomized to receive @ weekly infusions of placebo , @ mg/kg , @ mg/kg , or @ mg/kg CER-@ .", "sentence_id": 6}
+{"abstract_id": "24780501", "label": "methods", "text": "The primary efficacy parameter was the nominal change in the total atheroma volume .", "sentence_id": 7}
+{"abstract_id": "24780501", "label": "methods", "text": "Nominal changes in per cent atheroma volume on IVUS and coronary scores on QCA were also pre-specified endpoints .", "sentence_id": 8}
+{"abstract_id": "24780501", "label": "results", "text": "The nominal change in the total atheroma volume ( adjusted means ) was -@ , -@ , -@ , and -@ mm ( @ ) with placebo , CER-@ @ mg/kg , @ mg/kg , and @ mg/kg , respectively ( primary analysis of @ mg/kg vs. placebo : P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24780501", "label": "results", "text": "There was also no difference among groups for the nominal change in per cent atheroma volume ( @ , -@ , @ , and @ % ; nominal P = @ for @ mg/kg vs. placebo ) .", "sentence_id": 10}
+{"abstract_id": "24780501", "label": "results", "text": "Change in the coronary artery score was -@ , -@ , -@ , and -@ mm ( nominal P = @ , @ , @ ) , and change in the cumulative coronary stenosis score was -@ , @ , @ , and -@ % ( compared with placebo , nominal P = @ for @ mg/kg and nominal P = @ for @ mg/kg ) .", "sentence_id": 11}
+{"abstract_id": "24780501", "label": "results", "text": "The number of patients with major cardiovascular events was @ ( @ % ) , @ ( @ % ) , @ ( @ % ) , and @ ( @ % ) in the four groups .", "sentence_id": 12}
+{"abstract_id": "24780501", "label": "conclusions", "text": "CER-@ infusions did not reduce coronary atherosclerosis on IVUS and QCA when compared with placebo .", "sentence_id": 13}
+{"abstract_id": "24780501", "label": "conclusions", "text": "Whether CER-@ administered in other regimens or to other populations could favourably affect atherosclerosis must await further study .", "sentence_id": 14}
+{"abstract_id": "24780501", "label": "conclusions", "text": "Name of the trial registry : Clinicaltrials.gov ; Registry 's URL : http://clinicaltrials.gov/ct@/show/NCT@?term=cer-@&rank=@;", "sentence_id": 15}
+{"abstract_id": "25675560", "label": "objective", "text": "To observe the effects of electroacupuncture at Neiguan ( PC @ ) and Jianshi ( PC @ ) com - bined with granisetron on nausea and vomiting as well as serum levels of @-hydroxy tryptamine ( @-HT ) and dopamine ( DA ) in chemotherapy patients .", "sentence_id": 0}
+{"abstract_id": "25675560", "label": "methods", "text": "Seventy-two chemotherapy patients who met the inclusive criteria were randomly divided into an observation group ( @ cases ) and a control group ( @ cases ) .", "sentence_id": 1}
+{"abstract_id": "25675560", "label": "methods", "text": "The patients in the observation group were treated with electroacupuncture at Neiguan ( PC @ ) and Jianshi ( PC @ ) combined with granisetron injection ; the patients in the control group were treated with electroacupuncture at sham-point @ and sham - point @ , and the rest treatment was identical to the observation group .", "sentence_id": 2}
+{"abstract_id": "25675560", "label": "methods", "text": "After @-day treatment , the clinical indices including times of vomiting and severity of nausea , etc. were observed in the two groups .", "sentence_id": 3}
+{"abstract_id": "25675560", "label": "results", "text": "( @ ) At the acute stage within @ h , the times of vomiting in the two groups were not significantly different ( P > @ ) ; at the delay stage , the severity of nausea was significantly higher in the control group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25675560", "label": "results", "text": "( @ ) As for the comprehensive efficacy and rate of complete control , there was no obvious difference between the two groups at the acute stage ( P > @ ) ; while in the delay stage , the rate of complete control in the observation group was superior to that in the control group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25675560", "label": "results", "text": "( @ ) Compared before and after the treatment , serum levels of @-HT and DA were evidently reduced in the observation group ( both P < @ ) , while those in the control group were not significantly changed after treatment ( both P > @ ) .", "sentence_id": 6}
+{"abstract_id": "25675560", "label": "conclusions", "text": "Electroacupuncture at Neiguan ( PC @ ) and Jianshi ( PC @ ) combined with granisetron could obviously relieve the nausea in chemotherapy patients at the delay stage .", "sentence_id": 7}
+{"abstract_id": "25675560", "label": "conclusions", "text": "The effect mechanism is possibly related to reducing the content of @-HIT nndl nA", "sentence_id": 8}
+{"abstract_id": "26349127", "label": "objective", "text": "The purpose of this study was to compare the reduction of the clinical signs of inflammation by two power interdental cleaning devices combined with a manual toothbrush .", "sentence_id": 0}
+{"abstract_id": "26349127", "label": "methods", "text": "Sixty-nine subjects completed this randomized , four-week , single-blind , two-group , parallel clinical study .", "sentence_id": 1}
+{"abstract_id": "26349127", "label": "methods", "text": "Subjects were randomly assigned to one of two treatment groups : Waterpik Water Flosser ( WF ) plus a manual toothbrush ; or Sonicare Air Floss Pro ( AFP ) plus a manual toothbrush .", "sentence_id": 2}
+{"abstract_id": "26349127", "label": "methods", "text": "All subjects received both written and verbal instructions and demonstrated proficiency prior to starting the study .", "sentence_id": 3}
+{"abstract_id": "26349127", "label": "methods", "text": "Instructions were reviewed at the two-week visit ( W@ ) .", "sentence_id": 4}
+{"abstract_id": "26349127", "label": "methods", "text": "Data were evaluated for whole mouth , lingual , and facial areas for bleeding on probing ( BOP ) and Modified Gingival Index ( MGI ) .", "sentence_id": 5}
+{"abstract_id": "26349127", "label": "methods", "text": "Plaque data were recorded for whole mouth , lingual , facial , approximal , and marginal areas of the tooth using the Rustogi Modification of the Navy Plaque Index ( RMNPI ) .", "sentence_id": 6}
+{"abstract_id": "26349127", "label": "methods", "text": "BOP , MGI , and RMNPI were scored at baseline ( BSL ) , two weeks , and four weeks ( W@ ) .", "sentence_id": 7}
+{"abstract_id": "26349127", "label": "results", "text": "Both groups showed significant reductions in BOP and MGI from baseline for all regions and time points measured ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "26349127", "label": "results", "text": "Both groups showed significant reductions from baseline for all areas at W@ for RMNPI ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "26349127", "label": "results", "text": "The WF group was significantly more effective than the AFP group at reducing bleeding and gingivitis for all areas measured at all time points .", "sentence_id": 10}
+{"abstract_id": "26349127", "label": "results", "text": "At W@ , the WF group was @ % more effective for bleeding and @ % for gingivitis ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "26349127", "label": "results", "text": "Plaque accumulation was significantly less at W@ for the WF group compared to the AFP group ( @ % , p @ ) .", "sentence_id": 12}
+{"abstract_id": "26349127", "label": "conclusions", "text": "The Waterpik Water Flosser is significantly more effective than the Sonicare Air Floss Pro for reducing clinical signs of inflammation .", "sentence_id": 13}
+{"abstract_id": "25579777", "label": "background", "text": "Streptococcus pneumoniae infections have periodically caused significant morbidity and outbreaks among military personnel , especially trainees .", "sentence_id": 0}
+{"abstract_id": "25579777", "label": "background", "text": "This study evaluated the effectiveness of the @-valent polysaccharide pneumococcal vaccine ( PPV@ ) in reducing pneumonia in healthy military trainees .", "sentence_id": 1}
+{"abstract_id": "25579777", "label": "methods", "text": "From @-@ , @ military trainees from @ US training camps were enrolled in a double-blind , placebo-controlled trial of PPV@ .", "sentence_id": 2}
+{"abstract_id": "25579777", "label": "methods", "text": "Participants were closely monitored during basic training for radiographically confirmed pneumonia etiology and loss-of-training days .", "sentence_id": 3}
+{"abstract_id": "25579777", "label": "methods", "text": "Participants were also followed using electronic medical encounter data until @ June @ for three additional outcomes : any-cause pneumonia , any acute respiratory disease , and meningitis .", "sentence_id": 4}
+{"abstract_id": "25579777", "label": "results", "text": "Comparison of demographic data by study arm suggested the randomization procedures were sound .", "sentence_id": 5}
+{"abstract_id": "25579777", "label": "results", "text": "During basic training , @ study participants developed radiographically confirmed pneumonia .", "sentence_id": 6}
+{"abstract_id": "25579777", "label": "results", "text": "None had evidence of S. pneumoniae infection , but other etiologies included adenovirus ( @ % ) , Chlamydophila pneumoniae ( @ % ) , and Mycoplasma pneumoniae ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "25579777", "label": "results", "text": "During the follow-up period , many study participants , in both the vaccine and placebo groups , had clinical encounters for the medical outcomes of interest .", "sentence_id": 8}
+{"abstract_id": "25579777", "label": "results", "text": "However , Cox 's proportional hazard modeling revealed no evidence of a protective vaccine effect during recruit training ( radiographically confirmed pneumonia ) or up to @ years after enrollment ( any-cause pneumonia , any acute respiratory disease , or meningitis ) .", "sentence_id": 9}
+{"abstract_id": "25579777", "label": "conclusions", "text": "Data from this large , double-blind , placebo controlled trial do not support routine use of PPV@ among healthy new military trainees .", "sentence_id": 10}
+{"abstract_id": "25579777", "label": "conclusions", "text": "This clinical trial was registered at clinicaltrials.gov ( registration number NCT@ , http://www.clinicaltrials.gov/ct@/show/NCT@?term=NCT@&rank=@ ) .", "sentence_id": 11}
+{"abstract_id": "24689093", "label": "objective", "text": "Both unsedated transoral endoscopy ( TOE ) and sedated TOE have some drawbacks in clinical practice .", "sentence_id": 0}
+{"abstract_id": "24689093", "label": "objective", "text": "Unsedated transnasal endoscopy ( TNE ) has been suggested as an alternative to both methods .", "sentence_id": 1}
+{"abstract_id": "24689093", "label": "objective", "text": "This study aimed to determine the advantages of TNE in patients who have previously undergone unsedated conventional TOE .", "sentence_id": 2}
+{"abstract_id": "24689093", "label": "methods", "text": "Patients who had received an unsedated TOE in the last @ months and were scheduled for a second upper endoscopy were included .", "sentence_id": 3}
+{"abstract_id": "24689093", "label": "methods", "text": "They were randomized to undergo either unsedated TOE , using a standard endoscope , or unsedated TNE , using an ultrathin endoscope .", "sentence_id": 4}
+{"abstract_id": "24689093", "label": "methods", "text": "Post-procedure , patients were asked to complete a questionnaire to assess pain , discomfort and acceptability of the procedure , and to compare the current procedure with their previous unsedated TOE .", "sentence_id": 5}
+{"abstract_id": "24689093", "label": "methods", "text": "Endoscope insertion rate , procedure duration , and side-effects were recorded .", "sentence_id": 6}
+{"abstract_id": "24689093", "label": "results", "text": "Each group included @ patients .", "sentence_id": 7}
+{"abstract_id": "24689093", "label": "results", "text": "With the exception of nasal pain , the tolerability and acceptance were significantly greater in the unsedated TNE group .", "sentence_id": 8}
+{"abstract_id": "24689093", "label": "results", "text": "Significantly more TNE patients ( @ % ) found the current endoscopic procedure to be better than their previous TOE when compared with patients who had received a second TOE ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24689093", "label": "results", "text": "A repeat procedure was significantly more acceptable for TNE patients when compared to the TOE group ( @ % vs. @ % ) .", "sentence_id": 10}
+{"abstract_id": "24689093", "label": "results", "text": "The duration of endoscopy was significantly shorter in TOE than in TNE ( p < @ ) .", "sentence_id": 11}
+{"abstract_id": "24689093", "label": "results", "text": "Endoscope insertion failed in @ % and mild epistaxis was observed in @ % of TNE patients .", "sentence_id": 12}
+{"abstract_id": "24689093", "label": "conclusions", "text": "Unsedated TNE was better tolerated in endoscopy experienced patients when compared with unsedated TOE .", "sentence_id": 13}
+{"abstract_id": "24689093", "label": "conclusions", "text": "The majority of patients found TNE more acceptable and preferable to TOE , suggesting that TNE should become a more common practice in clinics when applicable .", "sentence_id": 14}
+{"abstract_id": "25301463", "label": "background", "text": "Little is known about mode of death after acute heart failure ( AHF ) hospitalization .", "sentence_id": 0}
+{"abstract_id": "25301463", "label": "background", "text": "In the RELAX-AHF ( Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure ) study , serelaxin , the recombinant form of human relaxin-@ , reduced post-discharge mortality at @ days in selected patients with AHF .", "sentence_id": 1}
+{"abstract_id": "25301463", "label": "objective", "text": "The goal of this study was to assess the effect of serelaxin on specific modes of death in patients with AHF .", "sentence_id": 2}
+{"abstract_id": "25301463", "label": "methods", "text": "The RELAX-AHF study randomized @,@ patients with AHF to @ h of therapy with intravenous serelaxin or placebo .", "sentence_id": 3}
+{"abstract_id": "25301463", "label": "methods", "text": "Patients were followed for vital status through @ days .", "sentence_id": 4}
+{"abstract_id": "25301463", "label": "methods", "text": "A blinded clinical events committee reviewed all deaths and adjudicated a cause of death on the basis of pre-specified criteria .", "sentence_id": 5}
+{"abstract_id": "25301463", "label": "methods", "text": "Cox proportional hazard models were used to assess the effect of serelaxin on each mode of death , on the basis of pre-specified groupings of mode of death .", "sentence_id": 6}
+{"abstract_id": "25301463", "label": "results", "text": "There were @ deaths ( @ % ) : @ ( @ % ) due to HF , @ ( @ % ) due to sudden death , @ ( @ % ) due to other cardiovascular ( CV ) causes , @ ( @ % ) due to non-CV causes , and @ ( @ % ) classified as unknown .", "sentence_id": 7}
+{"abstract_id": "25301463", "label": "results", "text": "The treatment effect of serelaxin was most pronounced on other CV deaths ( hazard ratio -LSB- HR -RSB- : @ ; @ % CI : @ to @ ; p = @ ) and sudden death ( HR : @ ; @ % CI : @ to @ ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25301463", "label": "results", "text": "There was no apparent impact of serelaxin treatment on HF deaths or non-CV deaths .", "sentence_id": 9}
+{"abstract_id": "25301463", "label": "conclusions", "text": "In the RELAX-AHF study , the effects of serelaxin on mortality were primarily driven by reduction in mortality from other CV causes and sudden death , without apparent impact on HF deaths .", "sentence_id": 10}
+{"abstract_id": "25301463", "label": "conclusions", "text": "( Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure -LSB- RELAX-AHF -RSB- ; NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "24837512", "label": "objective", "text": "Aerosol immunization may be a useful tool to reach and sustain the elimination of measles , rubella , and congenital rubella syndrome .", "sentence_id": 0}
+{"abstract_id": "24837512", "label": "objective", "text": "We compared booster seroresponses to aerosolized or injected MMR vaccines containing different strains of measles ( Attenuvax or Edmonston-Zagreb ) and mumps ( Jeryl-Lynn or Leningrad-Zagreb ) .", "sentence_id": 1}
+{"abstract_id": "24837512", "label": "objective", "text": "To assess the safety and immunogenicity of two MMR : Vaccines administered by aerosol .", "sentence_id": 2}
+{"abstract_id": "24837512", "label": "methods", "text": "A randomized and controlled clinical trial was conducted to evaluate the safety and booster responses to the MMR SII ( Serum Institute of India ) and MMR II ( Merck Sharp & Dhome ) vaccines , both of which were administered by aerosol ( ae ) or injection ( inj ) to Mexican children aged @-@ years in elementary schools .", "sentence_id": 3}
+{"abstract_id": "24837512", "label": "methods", "text": "The seroresponses were evaluated by PRN ( measles ) and ELISA ( rubella and mumps ) .", "sentence_id": 4}
+{"abstract_id": "24837512", "label": "methods", "text": "Adverse events were followed-up for @ days after the immunization .", "sentence_id": 5}
+{"abstract_id": "24837512", "label": "results", "text": "Two hundred and fifty-three of @ children completed the one-month follow-up .", "sentence_id": 6}
+{"abstract_id": "24837512", "label": "results", "text": "All participants reached protective seropositivity for measles and rubella after immunization , and @ to @ % reached protective seropositivity for mumps ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24837512", "label": "results", "text": "The proportions of the seroresponses ( a @-fold rise from the baseline antibody titers ) to measles were @ % for MMR SII ( ae ) , @ % for MMR II ( ae ) , @ % for MMR SII ( inj ) , and @ % for MMR II ( inj ) ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24837512", "label": "results", "text": "The seroresponses for rubella were @ % for MMR SII ( ae ) , @ % for MMR II ( ae ) , @ % for MMR SII ( inj ) , and @ % for MMR II ( inj ) ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24837512", "label": "results", "text": "The seroresponse to mumps were @ % for MMR SII ( ae ) , @ % for MMR II ( ae ) , @ % for MMR SII ( inj ) , and @ % for MMR II ( inj ) ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24837512", "label": "results", "text": "The difference in the seroresponse of a @-fold rise from the baseline antibody titers was not statistically significant .", "sentence_id": 11}
+{"abstract_id": "24837512", "label": "results", "text": "Only mild adverse events were noted .", "sentence_id": 12}
+{"abstract_id": "24837512", "label": "conclusions", "text": "Aerosolized vaccines were as safe and as immunogenic as injected vaccines .", "sentence_id": 13}
+{"abstract_id": "25316259", "label": "background", "text": "We evaluated the efficacy and safety of S-@ plus oxaliplatin ( SOX ) as an alternative to cisplatin plus S-@ ( CS ) in first-line chemotherapy for advanced gastric cancer ( AGC ) .", "sentence_id": 0}
+{"abstract_id": "25316259", "label": "methods", "text": "In this randomized , open-label , multicenter phase III study , patients were randomly assigned to receive SOX ( @-@ mg/day S-@ for @ weeks with @ mg/m ( @ ) oxaliplatin on day @ , every @ weeks ) or CS ( S-@ for @ weeks with @ mg/m ( @ ) cisplatin on day @ , every @ weeks ) .", "sentence_id": 1}
+{"abstract_id": "25316259", "label": "methods", "text": "The primary end points were noninferiority in progression-free survival ( PFS ) and relative efficacy in overall survival ( OS ) for SOX using adjusted hazard ratios ( HRs ) with stratification factors ; performance status and unresectable or recurrent ( + adjuvant chemotherapy ) disease .", "sentence_id": 2}
+{"abstract_id": "25316259", "label": "results", "text": "Overall , @ patients were randomized from January @ to October @ .", "sentence_id": 3}
+{"abstract_id": "25316259", "label": "results", "text": "In per-protocol population , SOX ( n = @ ) was noninferior to CS ( n = @ ) in PFS -LSB- median , @ versus @ months ; HR @ , @ % confidence interval ( CI ) @-@ @ ; predefined noninferiority margin @ -RSB- .", "sentence_id": 4}
+{"abstract_id": "25316259", "label": "results", "text": "The median OS for SOX and CS were @ and @ months , respectively ( HR @ with @ % CI @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25316259", "label": "results", "text": "In the intention-to-treat population ( SOX , n = @ ; CS , n = @ ) , the HRs in PFS and OS were @ ( @ % CI @-@ @ ) and @ ( @ % CI @-@ @ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "25316259", "label": "results", "text": "The most common grade @ adverse events ( SOX versus CS ) were neutropenia ( @ % versus @ % ) , anemia ( @ % versus @ % ) , hyponatremia ( @ % versus @ % ) , febrile neutropenia ( @ % versus @ % ) , and sensory neuropathy ( @ % versus @ % ) .", "sentence_id": 7}
+{"abstract_id": "25316259", "label": "conclusions", "text": "SOX is as effective as CS for AGC with favorable safety profile , therefore SOX can replace CS .", "sentence_id": 8}
+{"abstract_id": "24585502", "label": "objective", "text": "To assess the differences in clinical outcome between complex patients treated with Resolute zotarolimus-eluting stents ( ZES ) versus Xience V everolimus-eluting stents ( EES ) .", "sentence_id": 0}
+{"abstract_id": "24585502", "label": "background", "text": "Nowadays , many complex patients with coronary disease are treated with percutaneous coronary interventions , using drug-eluting stents ( DES ) .", "sentence_id": 1}
+{"abstract_id": "24585502", "label": "methods", "text": "We analyzed @-year outcome data of @,@ complex patients of the TWENTE trial , treated with second-generation Resolute ZES or Xience V EES .", "sentence_id": 2}
+{"abstract_id": "24585502", "label": "methods", "text": "Complex patients had at least one of the following characteristics : renal insufficiency ( creatinine@ mol/l ) ; ejection fraction < @ % ; acute myocardial infarction ( MI ) within previous @ hrs ; > @ lesion/vessel ; > @ vessels treated ; lesion length > @ mm ; bifurcation ; saphenous vein graft lesion ; arterial bypass graft lesion ; in-stent restenosis ; unprotected left main lesion ; lesion with thrombus ; or lesion with total occlusion .", "sentence_id": 3}
+{"abstract_id": "24585502", "label": "methods", "text": "Target vessel failure ( TVF ) , the primary composite endpoint of the trial , was defined as cardiac death , target vessel-related MI , or target vessel revascularization .", "sentence_id": 4}
+{"abstract_id": "24585502", "label": "results", "text": "Among the @,@ complex patients , @ ( @ % ) were treated with Resolute ZES and @ ( @ % ) with Xience V EES .", "sentence_id": 5}
+{"abstract_id": "24585502", "label": "results", "text": "Patient - and procedure-related characteristics were similar between DES groups .", "sentence_id": 6}
+{"abstract_id": "24585502", "label": "results", "text": "After @-year follow-up , outcome was also similar between DES groups .", "sentence_id": 7}
+{"abstract_id": "24585502", "label": "results", "text": "TVF occurred in @ % of patients treated with Resolute ZES and @ % of patients treated with Xience V EES .", "sentence_id": 8}
+{"abstract_id": "24585502", "label": "results", "text": "In addition , DES groups did not differ significantly in cardiac death , MI , or target vessel revascularization-the individual components of TVF .", "sentence_id": 9}
+{"abstract_id": "24585502", "label": "conclusions", "text": "Complex patients treated with Resolute ZES and Xience V EES showed similar safety and efficacy during @-year follow-up .", "sentence_id": 10}
+{"abstract_id": "24585502", "label": "conclusions", "text": "@ Wiley Periodicals , Inc. .", "sentence_id": 11}
+{"abstract_id": "25222001", "label": "objective", "text": "The aim of this study was to compare the use of multilayer amniotic membrane transplantation ( AMT ) with lamellar corneal transplantation ( LCT ) and lamellar scleral transplantation ( LST ) for the treatment of scleral thinning after pterygium surgery associated with beta therapy .", "sentence_id": 0}
+{"abstract_id": "25222001", "label": "methods", "text": "Twenty-six eyes from @ different patients with scleral thinning as a consequence of beta therapy after pterygium surgery were evaluated at the Federal University of So Paulo , Brazil .", "sentence_id": 1}
+{"abstract_id": "25222001", "label": "methods", "text": "Ophthalmologic examination and ultrasound biomicroscopy were performed to assess scleral thinning before the transplant surgery and then repeated at @ , @ , and @ days after surgery .", "sentence_id": 2}
+{"abstract_id": "25222001", "label": "methods", "text": "An increase in scleral thickness , epithelialization of the ocular surface , and preservation of the ocular globe were the main outcome measures .", "sentence_id": 3}
+{"abstract_id": "25222001", "label": "results", "text": "Irrespective of the surgical technique used ( AMT , LCT , or LST ) , no clinical or statistical changes in corrected distance visual acuity were found in any of the patients during this study .", "sentence_id": 4}
+{"abstract_id": "25222001", "label": "results", "text": "The median preoperative scleral thickness was similar in all @ groups : AMT = @ mm , LST = @ mm , and LCT = @ mm ( P = @ ) ; however , @ months after surgery , the median thickness in the AMT group ( @ ) was significantly less than that of the LCT group ( @ ) ( P = @ ) or the LST group ( @ ) ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25222001", "label": "results", "text": "Epithelialization occurred in all the patients .", "sentence_id": 6}
+{"abstract_id": "25222001", "label": "conclusions", "text": "LCT was the best option for the structural treatment of scleral thinning , followed by LST with a conjunctival flap .", "sentence_id": 7}
+{"abstract_id": "25222001", "label": "conclusions", "text": "A high rate of reabsorption was found with AMT , which was the least effective of the @ therapeutic options and should not be used for this condition .", "sentence_id": 8}
+{"abstract_id": "24752193", "label": "background", "text": "Agility is a determinant component in soccer performance .", "sentence_id": 0}
+{"abstract_id": "24752193", "label": "background", "text": "This study aimed to evaluate the reliability and sensitivity of a `` Modified Illinois change of direction test '' ( MICODT ) in ninety-five U-@ soccer players .", "sentence_id": 1}
+{"abstract_id": "24752193", "label": "methods", "text": "A total of @ U-@ soccer players ( mean SD : age : @ @ years ; body mass : @ @ kg ; height : @ @ m ) from a professional and semi-professional soccer academy , participated to this study .", "sentence_id": 2}
+{"abstract_id": "24752193", "label": "methods", "text": "Sixty of them took part in reliability analysis and thirty-two in sensitivity analysis .", "sentence_id": 3}
+{"abstract_id": "24752193", "label": "results", "text": "The intraclass correlation coefficient ( ICC ) that aims to assess relative reliability of the MICODT was of @ , and its standard error of measurement ( SEM ) for absolute reliability was < @ % ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "24752193", "label": "results", "text": "The MICODT 's capacity to detect change is `` good '' , it 's SEM ( @ s ) was SWC ( @ s ) .", "sentence_id": 5}
+{"abstract_id": "24752193", "label": "results", "text": "The MICODT is significantly correlated to the Illinois change of direction speed test ( ICODT ) ( r = @ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24752193", "label": "results", "text": "The ICODT 's MDC@ ( @ s ) was twice about the MICODT 's MDC@ ( @ s ) , indicating that MICODT presents better ability to detect true changes than ICODT .", "sentence_id": 7}
+{"abstract_id": "24752193", "label": "results", "text": "The MICODT provided good sensitivity since elite U-@ soccer players were better than non-elite one on MICODT ( p = @ ; dz = @ -LSB- large -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "24752193", "label": "results", "text": "This was supported by an area under the ROC curve of @ ( CI @ % , @ to @ , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24752193", "label": "results", "text": "The difference observed in these two groups in ICODT was not statistically significant ( p = @ ; dz = @ -LSB- small -RSB- ) , showing poor discriminant ability .", "sentence_id": 10}
+{"abstract_id": "24752193", "label": "conclusions", "text": "MICODT can be considered as more suitable protocol for assessing agility performance level than ICODT in U-@ soccer players .", "sentence_id": 11}
+{"abstract_id": "25127655", "label": "background", "text": "Perioperative management with reduced-dose warfarin is of potential interest by eliminating the need for bridging while still maintaining a degree of anticoagulation .", "sentence_id": 0}
+{"abstract_id": "25127655", "label": "background", "text": "The outcomes of this regimen have not been well determined .", "sentence_id": 1}
+{"abstract_id": "25127655", "label": "methods", "text": "In a randomized controlled trial we compared two regimens for management of anticoagulation with warfarin in patients with implantation of a pacemaker or defibrillator .", "sentence_id": 2}
+{"abstract_id": "25127655", "label": "methods", "text": "Half dose of warfarin for @-@ days , depending on the baseline international normalized ratio ( INR ) , before surgery aiming at an INR of @ was compared with interrupted warfarin for @ days with preoperative bridging with low-molecular-weight heparin ( LMWH ) at therapeutic dose for @ days .", "sentence_id": 3}
+{"abstract_id": "25127655", "label": "methods", "text": "Main safety outcome was pocket hematoma .", "sentence_id": 4}
+{"abstract_id": "25127655", "label": "methods", "text": "Secondary outcomes were major bleeding , thromboembolism - all within @ month , days of hospitalization and number of patients requiring correction of INR with vitamin K.", "sentence_id": 5}
+{"abstract_id": "25127655", "label": "results", "text": "The study was planned for @ patients but it was discontinued prematurely due to a change in practice .", "sentence_id": 6}
+{"abstract_id": "25127655", "label": "results", "text": "Pocket hematoma occurred in @ of @ patients ( @ % ) randomized to the bridged regimen and in @ of @ patients ( @ % ) randomized to reduced-dose warfarin .", "sentence_id": 7}
+{"abstract_id": "25127655", "label": "results", "text": "One pocket hematoma in each group was severe .", "sentence_id": 8}
+{"abstract_id": "25127655", "label": "results", "text": "There were no major hemorrhages or thromboembolism within the @-month window .", "sentence_id": 9}
+{"abstract_id": "25127655", "label": "results", "text": "Duration of hospitalization was similar in the two groups .", "sentence_id": 10}
+{"abstract_id": "25127655", "label": "results", "text": "Correction of INR the day before surgery with vitamin K had to be used for significantly more patients in the reduced-dose warfarin group ( @ % ) than in the bridged regimen group ( @ % ) .", "sentence_id": 11}
+{"abstract_id": "25127655", "label": "conclusions", "text": "The reduced-dose warfarin regimen appeared to have similar safety after device implantation as interrupted warfarin with preoperative LMWH bridging .", "sentence_id": 12}
+{"abstract_id": "25127655", "label": "conclusions", "text": "Due to premature discontinuation no firm conclusion can be drawn .", "sentence_id": 13}
+{"abstract_id": "25127655", "label": "conclusions", "text": "The reduced-dose warfarin regimen often failed to achieve the intended preoperative INR .", "sentence_id": 14}
+{"abstract_id": "25127655", "label": "conclusions", "text": "ClinicalTrials.gov Identifier : NCT @ .", "sentence_id": 15}
+{"abstract_id": "24744200", "label": "objective", "text": "This study introduces a method to calculate myocardium blood flow ( MBF ) and coronary flow reserve ( CFR ) using the relatively low-dose dynamic @-row multi-detector computed tomography ( MDCT ) , validates the method against ( @ ) O-HO positron-emission tomography ( PET ) and assesses the CFRs of coronary artery disease ( CAD ) patients .", "sentence_id": 0}
+{"abstract_id": "24744200", "label": "methods", "text": "Thirty-two subjects underwent both dynamic CT perfusion ( CTP ) and PET perfusion imaging at rest and during pharmacological stress .", "sentence_id": 1}
+{"abstract_id": "24744200", "label": "methods", "text": "In @ normal subjects ( pilot group ) , the calculation method for MBF and CFR was established .", "sentence_id": 2}
+{"abstract_id": "24744200", "label": "methods", "text": "In the other @ normal subjects ( validation group ) , MBF and CFR obtained by dynamic CTP and PET were compared .", "sentence_id": 3}
+{"abstract_id": "24744200", "label": "methods", "text": "Finally , the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24744200", "label": "results", "text": "Correlation between MBF of MDCT and PET was strong ( r = @ , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24744200", "label": "results", "text": "CFR showed good correlation between dynamic CTP and PET ( r = @ , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24744200", "label": "results", "text": "CFRCT in the CAD group ( @ ) was significantly lower than that in the validation group ( @ ) ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24744200", "label": "conclusions", "text": "We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT .", "sentence_id": 8}
+{"abstract_id": "24744200", "label": "conclusions", "text": "Lower CFR was well demonstrated in CAD patients by dynamic CTP .", "sentence_id": 9}
+{"abstract_id": "24744200", "label": "conclusions", "text": "MBF and CFR can be calculated using dynamic CTP with @-row MDCT .", "sentence_id": 10}
+{"abstract_id": "24744200", "label": "conclusions", "text": "MBF and CFR showed good correlation between dynamic CTP and PET .", "sentence_id": 11}
+{"abstract_id": "24744200", "label": "conclusions", "text": "Lower CFR was well demonstrated in CAD patients by dynamic CTP .", "sentence_id": 12}
+{"abstract_id": "25124510", "label": "background", "text": "The presence of depressive subsyndromal symptoms ( SS ) in bipolar disorder ( BD ) increases the risk of affective relapse and worsens social , cognitive functioning , and quality of life .", "sentence_id": 0}
+{"abstract_id": "25124510", "label": "background", "text": "Nonetheless , there are limited data on how to optimize the treatment of subthreshold depressive symptoms in BD .", "sentence_id": 1}
+{"abstract_id": "25124510", "label": "background", "text": "Mindfulness-Based Cognitive Therapy ( MBCT ) is a psychotherapeutic intervention that has been shown effective in unipolar depression .", "sentence_id": 2}
+{"abstract_id": "25124510", "label": "background", "text": "The assessment of its clinical effectiveness and its impact on biomarkers in bipolar disorder patients with subsyndromal depressive symptoms and psychopharmacological treatment is needed .", "sentence_id": 3}
+{"abstract_id": "25124510", "label": "methods", "text": "A randomized , multicenter , prospective , versus active comparator , evaluator-blinded clinical trial is proposed .", "sentence_id": 4}
+{"abstract_id": "25124510", "label": "methods", "text": "Patients with BD and subclinical or mild depressive symptoms will be randomly allocated to : @ ) MBCT added to psychopharmacological treatment ; @ ) a brief structured group psychoeducational intervention added to psychopharmacological treatment ; @ ) standard clinical management , including psychopharmacological treatment .", "sentence_id": 5}
+{"abstract_id": "25124510", "label": "methods", "text": "Assessments will be conducted at screening , baseline , post-intervention ( @ weeks ) and @ month follow-up post-intervention .", "sentence_id": 6}
+{"abstract_id": "25124510", "label": "methods", "text": "The aim is to compare MBCT intervention versus a brief structured group psychoeducation .", "sentence_id": 7}
+{"abstract_id": "25124510", "label": "methods", "text": "Our hypothesis is that MBCT will be more effective in reducing the subsyndromal depressive symptoms and will improve cognitive performance to a higher degree than the psychoeducational treatment .", "sentence_id": 8}
+{"abstract_id": "25124510", "label": "methods", "text": "It is also hypothesized that a significant increase of BDNF levels will be found after the MBCT intervention .", "sentence_id": 9}
+{"abstract_id": "25124510", "label": "conclusions", "text": "This is the first randomized controlled trial to evaluate the effects of MBCT compared to an active control group on depressive subthreshold depressive symptoms in patients with bipolar disorder .", "sentence_id": 10}
+{"abstract_id": "24995901", "label": "background", "text": "Residual inhibition ( RI ) is the temporary inhibition of tinnitus by use of masking stimuli when the device is turned off .", "sentence_id": 0}
+{"abstract_id": "24995901", "label": "objective", "text": "The main aim of this study was to evaluate the effects of RI induced by auditory electrical stimulation ( AES ) in the primary auditory pathways using early auditory-evoked potentials ( AEPs ) in subjective idiopathic tinnitus ( SIT ) subjects .", "sentence_id": 1}
+{"abstract_id": "24995901", "label": "methods", "text": "A randomized placebo-controlled study was conducted on forty-four tinnitus subjects .", "sentence_id": 2}
+{"abstract_id": "24995901", "label": "methods", "text": "All enrolled subjects based on the responses to AES , were divided into two groups of RI and Non-RI ( NRI ) .", "sentence_id": 3}
+{"abstract_id": "24995901", "label": "methods", "text": "The results of the electrocochleography ( ECochG ) , auditory brain stem response ( ABR ) and brain stem transmission time ( BTT ) were determined and compared pre - and post-AES in the studied groups .", "sentence_id": 4}
+{"abstract_id": "24995901", "label": "results", "text": "The mean differences in the compound action potential ( CAP ) amplitudes and III/V and I/V amplitude ratios were significantly different between the RI , NRI and PES controls .", "sentence_id": 5}
+{"abstract_id": "24995901", "label": "results", "text": "BTT was significantly decreased associated with RI .", "sentence_id": 6}
+{"abstract_id": "24995901", "label": "conclusions", "text": "The observed changes in AEP associated with RI suggested some peripheral and central auditory alterations .", "sentence_id": 7}
+{"abstract_id": "24995901", "label": "conclusions", "text": "Synchronized discharges of the auditory nerve fibers and inhibition of the abnormal activity of the cochlear nerve by AES may play important roles associated with RI .", "sentence_id": 8}
+{"abstract_id": "24995901", "label": "conclusions", "text": "Further comprehensive studies are required to determine the mechanisms of RI more precisely .", "sentence_id": 9}
+{"abstract_id": "25169073", "label": "background", "text": "In sub-Saharan Africa , malaria continues to cause over @,@ maternal deaths and @,@ to @,@ infant deaths .", "sentence_id": 0}
+{"abstract_id": "25169073", "label": "background", "text": "Successful control of malaria in pregnancy could save lives of mothers and babies and is an essential part of antenatal care in endemic areas .", "sentence_id": 1}
+{"abstract_id": "25169073", "label": "background", "text": "The primary objective is to determine the protective efficacy of community-scheduled screening and treatment ( CSST ) using community health workers ( CHW ) against the primary outcome of prevalence of placental malaria .", "sentence_id": 2}
+{"abstract_id": "25169073", "label": "background", "text": "The secondary objectives are to determine the protective efficacy of CSST on maternal anaemia , maternal peripheral infection , low birth weight , selection of sulfadoxine-pyrimethamine ( SP ) resistance markers , and on antenatal clinic ( ANC ) attendance and coverage of intermittent preventive treatment during pregnancy ( IPTp-SP ) .", "sentence_id": 3}
+{"abstract_id": "25169073", "label": "methods", "text": "This is a multi-centre cluster-randomised controlled trial involving three countries with varying malaria endemicity ; low ( The Gambia ) versus high transmission ( Burkina Faso and Benin ) , and varying degrees of SP resistance ( high in Benin and moderate in Gambia and Burkina Faso ) .", "sentence_id": 4}
+{"abstract_id": "25169073", "label": "methods", "text": "CHW and their related catchment population who are randomised into the intervention arm will receive specific training on community-based case management of malaria in pregnancy .", "sentence_id": 5}
+{"abstract_id": "25169073", "label": "methods", "text": "All women in both study arms will be enrolled at their first ANC visits in their second trimester where they will receive their first dose of IPTp-SP .", "sentence_id": 6}
+{"abstract_id": "25169073", "label": "methods", "text": "Thereafter , CHW in the intervention arm will perform scheduled monthly screening and treatment in the womens homes .", "sentence_id": 7}
+{"abstract_id": "25169073", "label": "methods", "text": "At time of delivery , a placental biopsy will be collected from all women to determine placental malaria .", "sentence_id": 8}
+{"abstract_id": "25169073", "label": "methods", "text": "At each contact point , filter paper and blood slides will be collected for detection of malaria infection and SP resistance markers .", "sentence_id": 9}
+{"abstract_id": "25169073", "label": "conclusions", "text": "To reach successful global malaria control , there is an urgent need to access those at greatest risk of malaria infection .", "sentence_id": 10}
+{"abstract_id": "25169073", "label": "conclusions", "text": "The project is designed to develop a low-cost intervention in pregnant women which will have an immediate impact on the malaria burden in resource-limited countries .", "sentence_id": 11}
+{"abstract_id": "25169073", "label": "conclusions", "text": "This will be done by adding to the standard IPTp-SP delivered through the health facilities : an `` extension '' strategy to the communities in rural areas thus bringing health services closer to where women live .", "sentence_id": 12}
+{"abstract_id": "24587337", "label": "objective", "text": "We studied the combined effects of wholegrain , fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome .", "sentence_id": 0}
+{"abstract_id": "24587337", "label": "methods", "text": "Altogether @ subjects ( @-@ y , BMI @-@ kg/m ( @ ) ) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with @-week periods according to a parallel study design .", "sentence_id": 1}
+{"abstract_id": "24587337", "label": "methods", "text": "They consumed either : a ) wholegrain and low postprandial insulin response grain products , fatty fish @ times a week , and bilberries @ portions per day ( HealthyDiet ) , b ) wholegrain and low postprandial insulin response grain products ( WGED ) , or c ) refined wheat breads as cereal products ( Control ) .", "sentence_id": 2}
+{"abstract_id": "24587337", "label": "methods", "text": "Altogether @ subjects completed the study .", "sentence_id": 3}
+{"abstract_id": "24587337", "label": "methods", "text": "Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites .", "sentence_id": 4}
+{"abstract_id": "24587337", "label": "results", "text": "There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention .", "sentence_id": 5}
+{"abstract_id": "24587337", "label": "results", "text": "Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group .", "sentence_id": 6}
+{"abstract_id": "24587337", "label": "results", "text": "All changes reflected increased polyunsaturation in plasma fatty acids , especially in n-@ PUFAs , while n-@ and n-@ fatty acids decreased .", "sentence_id": 7}
+{"abstract_id": "24587337", "label": "results", "text": "According to tertiles of changes in fish intake , a greater increase of fish intake was associated with increased concentration of large HDL particles , larger average diameter of HDL particles , and increased concentrations of large HDL lipid components , even though total levels of HDL cholesterol remained stable .", "sentence_id": 8}
+{"abstract_id": "24587337", "label": "conclusions", "text": "The results suggest that consumption of diet rich in whole grain , bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles .", "sentence_id": 9}
+{"abstract_id": "24587337", "label": "conclusions", "text": "These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis .", "sentence_id": 10}
+{"abstract_id": "25496303", "label": "background", "text": "Ciclosporin is approved for the treatment of atopic dermatitis ( AD ) in dogs and has been shown to be safe and effective .", "sentence_id": 0}
+{"abstract_id": "25496303", "label": "background", "text": "Placebo-controlled studies suggest that oclacitinib is a safe and effective alternative therapy .", "sentence_id": 1}
+{"abstract_id": "25496303", "label": "objective", "text": "To evaluate the efficacy and safety of oclacitinib , in comparison to ciclosporin , for the control of AD in a blinded , randomized clinical trial , incorporating a noninferiority test at day @ .", "sentence_id": 2}
+{"abstract_id": "25496303", "label": "methods", "text": "A total of @ client-owned dogs with a history of AD from eight sites were enrolled .", "sentence_id": 3}
+{"abstract_id": "25496303", "label": "methods", "text": "Enrolled animals were randomized to receive oral oclacitinib ( @-@ @ mg/kg twice daily for @ days , then once daily ) or oral ciclosporin ( @-@ @ mg/kg once daily ) for @ weeks .", "sentence_id": 4}
+{"abstract_id": "25496303", "label": "methods", "text": "Owners assessed pruritus using an enhanced visual analog scale ( VAS ) , and veterinarians assessed dermatitis using the Canine Atopic Dermatitis Extent and Severity Index ( CADESI ) -@ .", "sentence_id": 5}
+{"abstract_id": "25496303", "label": "results", "text": "On days @ , @ , @ , @ , @ , @ and @ , the percentage reduction from baseline for owner-assessed pruritus changed from @ to @ % in the oclacitinib group compared with @ to @ % in the ciclosporin group ; differences were significant at all time points up to day @ .", "sentence_id": 6}
+{"abstract_id": "25496303", "label": "results", "text": "On day @ , ciclosporin-treated dogs showed a similar decrease in pruritus to oclacitinib-treated dogs .", "sentence_id": 7}
+{"abstract_id": "25496303", "label": "results", "text": "On day @ , the percentage reduction from baseline CADESI-@ was significantly greater in the oclacitinib group ( @ % ) than in the ciclosporin group ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "25496303", "label": "results", "text": "Three times as many adverse events attributed to gastrointestinal signs were reported in the ciclosporin group compared with the oclacitinib group .", "sentence_id": 9}
+{"abstract_id": "25496303", "label": "conclusions", "text": "In this study of treatment for canine AD , oclacitinib had a faster onset of action and a lower frequency of gastrointestinal side effects compared with ciclosporin .", "sentence_id": 10}
+{"abstract_id": "24392964", "label": "objective", "text": "The purpose of this randomized , controlled clinical trial was to compare the effectiveness of a new treatment approach , which consisted of laterally positioned flap ( LPF ) procedure combined with an external vestibular releasing incision made by a diode laser ( LALPF ) to LPF alone for the treatment of isolated gingival recession defects .", "sentence_id": 0}
+{"abstract_id": "24392964", "label": "methods", "text": "Thirty-two healthy patients presenting single Miller class II isolated gingival recessions with minimal loss of interdental papilla were treated with an LPF technique .", "sentence_id": 1}
+{"abstract_id": "24392964", "label": "methods", "text": "Sixteen patients were randomly assigned to the test group ( laser-assisted laterally positioned flap -LSB- LALPF -RSB- ) , and the other @ patients were assigned to the control group ( LPF ) .", "sentence_id": 2}
+{"abstract_id": "24392964", "label": "methods", "text": "In the test group , diode laser was used for vestibular deepening in order to obtain maximum maneuverability of the advanced flap .", "sentence_id": 3}
+{"abstract_id": "24392964", "label": "methods", "text": "Clinical and patient-centered parameters ( visual analog scale for pain and aesthetics -LSB- VAS -RSB- ) were measured at baseline , @ days , and @ months after the surgery .", "sentence_id": 4}
+{"abstract_id": "24392964", "label": "results", "text": "Complete root coverage from baseline to @ months post-surgery was achieved for @ % of the control group and @ % of the test group ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24392964", "label": "results", "text": "There were no differences in VAS pain measurements between the groups .", "sentence_id": 6}
+{"abstract_id": "24392964", "label": "results", "text": "Patient satisfaction with aesthetics was higher in LALPF group than in the LPF group .", "sentence_id": 7}
+{"abstract_id": "24392964", "label": "conclusions", "text": "Six month results showed that the LALPF approach was effective for the treatment of single Miller class II gingival recessions .", "sentence_id": 8}
+{"abstract_id": "24981461", "label": "objective", "text": "To evaluate the analgesic efficacy of oral premedication of oxycodone in a group of patients undergoing elective uterine artery embolization under sedation for fibroid disease .", "sentence_id": 0}
+{"abstract_id": "24981461", "label": "methods", "text": "Thirty-nine patients ( mean age @ years ) were prospectively randomized @:@ to receive @ mg oxycodone or placebo orally immediately before their procedure .", "sentence_id": 1}
+{"abstract_id": "24981461", "label": "methods", "text": "At the commencement of the procedure , patients were provided with a patient-controlled analgesia device for @ h , programmed to deliver @ mg boluses of intravenous morphine with a @ min lockout .", "sentence_id": 2}
+{"abstract_id": "24981461", "label": "methods", "text": "Mean visual analog scale pain intensity ratings ( @-@ mm ) were measured from both groups and evaluated over @ to @ h as the primary end point .", "sentence_id": 3}
+{"abstract_id": "24981461", "label": "methods", "text": "Other measured parameters included opioid-related side effects and eligibility for discharge ( NCT@ ; September @ , @ ) .", "sentence_id": 4}
+{"abstract_id": "24981461", "label": "results", "text": "Early pain intensity did not vary significantly between the active and placebo groups -LSB- mean ( standard deviation ) : @ ( @ ) vs. @ ( @ ) , p = @ -RSB- .", "sentence_id": 5}
+{"abstract_id": "24981461", "label": "results", "text": "The oxycodone group , however , experienced significantly more nausea ( p = @ ) and a greater incidence of vomiting ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24981461", "label": "results", "text": "Overall opioid requirement over @ h , measured as oral morphine equivalent , was greater in the oxycodone group ( median -LSB- interquartile range -RSB- : @ -LSB- @-@ -RSB- mg vs. @ -LSB- @-@ @ -RSB- mg , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24981461", "label": "results", "text": "The number of patients first eligible for discharge at @ h in the oxycodone group was decreased but not significantly ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24981461", "label": "conclusions", "text": "The addition of preprocedural oral oxycodone to morphine patient-controlled analgesia does not offer any analgesic advantage to patients having uterine artery embolization and may cause a greater incidence of nausea and vomiting .", "sentence_id": 9}
+{"abstract_id": "24993832", "label": "objective", "text": "In light of the high prevalence of sleep disorders in patients suffering from posttraumatic stress disorder ( PTSD ) , this study sought to compare the effect of prazosin and hydroxyzine on sleep quality in this patient group .", "sentence_id": 0}
+{"abstract_id": "24993832", "label": "methods", "text": "A total of @ patients suffering from PTSD were assessed ( mean age = @ years , SD = @ ; @ % females ) .", "sentence_id": 1}
+{"abstract_id": "24993832", "label": "methods", "text": "Next , they were randomly assigned to one of three treatment groups : prazosin ( @ patients ) , hydroxyzine ( @ patients ) or placebo ( @ patients ) .", "sentence_id": 2}
+{"abstract_id": "24993832", "label": "methods", "text": "The trial lasted for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24993832", "label": "methods", "text": "The patients ' sleep quality was assessed using the Pittsburgh Sleep Quality Index .", "sentence_id": 4}
+{"abstract_id": "24993832", "label": "methods", "text": "Items taken from the Mini International Neuropsychiatric Interview were used to operationalize PTSD .", "sentence_id": 5}
+{"abstract_id": "24993832", "label": "results", "text": "Compared to controls , patients treated with prazosin and hydroxyzine reported improved sleep and less nightmares .", "sentence_id": 6}
+{"abstract_id": "24993832", "label": "results", "text": "Improvement was greatest in patients treated with prazosin compared to hydroxyzine and placebo .", "sentence_id": 7}
+{"abstract_id": "24993832", "label": "results", "text": "Improvement in sleep was associated with an amelioration of their PTSD symptoms .", "sentence_id": 8}
+{"abstract_id": "24993832", "label": "conclusions", "text": "Both prazosin and hydroxyzine can be used to treat psychopharmacological sleep disorders and nightmares in patients suffering from PTSD , also leading to reductions in PTSD symptoms .", "sentence_id": 9}
+{"abstract_id": "24939928", "label": "background", "text": "Reinfarction after primary percutaneous coronary intervention in patients with ST-segment-elevation myocardial infarction has negative consequences .", "sentence_id": 0}
+{"abstract_id": "24939928", "label": "background", "text": "Little is known about reinfarction after drug-eluting stents and bivalirudin anticoagulation .", "sentence_id": 1}
+{"abstract_id": "24939928", "label": "background", "text": "We , therefore , sought to determine the incidence , predictors , and implications of reinfarction after primary percutaneous coronary intervention in the contemporary era .", "sentence_id": 2}
+{"abstract_id": "24939928", "label": "results", "text": "Outcomes were assessed in @ patients undergoing stent implantation for ST-segment-elevation myocardial infarction in the Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction ( HORIZONS-AMI ) trial .", "sentence_id": 3}
+{"abstract_id": "24939928", "label": "results", "text": "Independent predictors of reinfarction and mortality were identified by Cox proportional hazards modeling .", "sentence_id": 4}
+{"abstract_id": "24939928", "label": "results", "text": "The cumulative incidence of reinfarction was @ % at @ days , @ % at @ year , and @ % at @ years .", "sentence_id": 5}
+{"abstract_id": "24939928", "label": "results", "text": "Definite stent thrombosis was responsible for @ % of reinfarctions occurring within @ days and @ % of all reinfarctions within @ years .", "sentence_id": 6}
+{"abstract_id": "24939928", "label": "results", "text": "Independent predictors of reinfarction were current smoking , Killip class @ , baseline thrombocytosis , multivessel disease , symptom onset-to-balloon time , and total stent length .", "sentence_id": 7}
+{"abstract_id": "24939928", "label": "results", "text": "Randomization to bivalirudin versus heparin plus a glycoprotein IIb/IIIa inhibitor and use of drug-eluting versus bare metal stents were not significant predictors of reinfarction .", "sentence_id": 8}
+{"abstract_id": "24939928", "label": "results", "text": "Reinfarction was a powerful independent predictor of subsequent cardiac mortality ( hazard ratio -LSB- @ % confidence interval -RSB- = @ -LSB- @-@ @ -RSB- ; P < @ ) and all-cause mortality ( hazard ratio -LSB- @ % confidence interval -RSB- = @ -LSB- @-@ @ -RSB- ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24939928", "label": "conclusions", "text": "Despite advances in pharmacotherapy and stents , reinfarction after primary percutaneous coronary intervention is not infrequent , in the contemporary era is most often attributable to stent thrombosis , and is strongly associated with subsequent cardiac and all-cause mortality .", "sentence_id": 10}
+{"abstract_id": "24939928", "label": "conclusions", "text": "Further enhancements in drugs and devices to prevent reinfarction are needed to improve outcomes in high-risk patients with ST-segment-elevation myocardial infarction .", "sentence_id": 11}
+{"abstract_id": "24935363", "label": "background", "text": "The aim of this study was to evaluate the efficacy of alternating etoposide-cisplatin and vinorelbine-cisplatin ( EP-NP ) compared with an etoposide-cisplatin ( EP ) regimen for advanced combined small cell carcinomas .", "sentence_id": 0}
+{"abstract_id": "24935363", "label": "methods", "text": "Histologically confirmed combined small cell carcinoma patients who met the inclusion criteria were randomly assigned ( @:@ ) into either the EP-NP setting ( group A ) or the EP setting ( group B ) .", "sentence_id": 1}
+{"abstract_id": "24935363", "label": "methods", "text": "The primary endpoint was progression-free survival in patients who received at least one dose of treatment .", "sentence_id": 2}
+{"abstract_id": "24935363", "label": "results", "text": "Eighty-two patients entered into this trial , @ in group A and @ in group B.", "sentence_id": 3}
+{"abstract_id": "24935363", "label": "results", "text": "The objective response rates in group A and group B were @ % and @ % , respectively ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24935363", "label": "results", "text": "Survival analysis showed that median progression-free survival was @ months in group A , which was significantly longer than the @ months in group B ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24935363", "label": "results", "text": "However , as to overall survival , no significant difference was found between the two groups ( @ vs @ months in groups A and B , respectively , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24935363", "label": "results", "text": "No unexpected side effects were observed in either group .", "sentence_id": 7}
+{"abstract_id": "24935363", "label": "conclusions", "text": "The EP-NP regimen for combined small cell carcinomas prolonged progression - free survival compared with the EP regimen .", "sentence_id": 8}
+{"abstract_id": "24935363", "label": "conclusions", "text": "Further clinical investigations are warranted .", "sentence_id": 9}
+{"abstract_id": "25455119", "label": "background", "text": "Limited evidence exists regarding the long-term effects of community health worker-led diabetes management programs on health outcomes and cost-effectiveness , particularly in low-income , ethnic minority populations .", "sentence_id": 0}
+{"abstract_id": "25455119", "label": "objective", "text": "To examine the long-term cost-effectiveness and improvements in diabetes-related complications of a diabetes education and management intervention led by community health workers among uninsured Mexican Americans .", "sentence_id": 1}
+{"abstract_id": "25455119", "label": "methods", "text": "Clinical data , changes in hemoglobin A@c over @ months , and costs from an RCT of @ uninsured Mexican Americans with type @ diabetes conducted in @ were utilized for secondary analyses in @ .", "sentence_id": 2}
+{"abstract_id": "25455119", "label": "methods", "text": "Simulation modeling was used to estimate long-term cost and health outcomes using the validated Archimedes Model .", "sentence_id": 3}
+{"abstract_id": "25455119", "label": "methods", "text": "The absolute differences for the incremental cost-effectiveness ratios and cumulative incidence of diabetes-related complications were derived by comparing intervention and control groups .", "sentence_id": 4}
+{"abstract_id": "25455119", "label": "results", "text": "During a @-year time horizon , participants who received the intervention would be expected to have significantly lower hemoglobin A@c levels ( p < @ ) , fewer foot ulcers ( p < @ ) , and a reduced number of foot amputations ( p = @ ) in comparison with a control group receiving usual medical care .", "sentence_id": 5}
+{"abstract_id": "25455119", "label": "results", "text": "An incremental cost-effectiveness ratio of $ @ per quality-adjusted life year gained was estimated for intervention participants during the same time period .", "sentence_id": 6}
+{"abstract_id": "25455119", "label": "conclusions", "text": "A simulated clinical trial suggests that a community health worker-led diabetes intervention is a cost-effective way to reduce diabetes-related complications for uninsured Mexican Americans during a @-year horizon in comparison to usual medical care .", "sentence_id": 7}
+{"abstract_id": "25047046", "label": "background", "text": "We report on the design and implementation of a study protocol entitled Acupuncture randomised trial for post anaesthetic recovery and postoperative pain - a pilot study ( ACUARP ) designed to investigate the effectiveness of acupuncture therapy performed in the perioperative period on post anaesthetic recovery and postoperative pain .", "sentence_id": 0}
+{"abstract_id": "25047046", "label": "methods", "text": "The study is designed as a randomised controlled pilot trial with three arms and partial double blinding .", "sentence_id": 1}
+{"abstract_id": "25047046", "label": "methods", "text": "We will compare ( a ) press needle acupuncture , ( b ) no treatment and ( c ) press plaster acupressure in a standardised anaesthetic setting .", "sentence_id": 2}
+{"abstract_id": "25047046", "label": "methods", "text": "Seventy-five patients scheduled for laparoscopic surgery to the uterus or ovaries will be allocated randomly to one of the three trial arms .", "sentence_id": 3}
+{"abstract_id": "25047046", "label": "methods", "text": "The total observation period will begin one day before surgery and end on the second postoperative day .", "sentence_id": 4}
+{"abstract_id": "25047046", "label": "methods", "text": "Twelve press needles and press plasters are to be administered preoperatively at seven acupuncture points .", "sentence_id": 5}
+{"abstract_id": "25047046", "label": "methods", "text": "The primary outcome measure will be time from extubation to ` ready for discharge ' from the post anaesthesia care unit ( in minutes ) .", "sentence_id": 6}
+{"abstract_id": "25047046", "label": "methods", "text": "The ` ready for discharge ' end point will be assessed using three different scores : the Aldrete score , the Post Anaesthetic Discharge Scoring System and an In-House score .", "sentence_id": 7}
+{"abstract_id": "25047046", "label": "methods", "text": "Secondary outcome measures will comprise pre - , intra - and postoperative variables ( which are anxiety , pain , nausea and vomiting , concomitant medication ) .", "sentence_id": 8}
+{"abstract_id": "25047046", "label": "conclusions", "text": "The results of this study will provide information on whether acupuncture may improve patient post anaesthetic recovery .", "sentence_id": 9}
+{"abstract_id": "25047046", "label": "conclusions", "text": "Comparing acupuncture with acupressure will provide insight into potential therapeutic differences between invasive and non-invasive acupuncture techniques .", "sentence_id": 10}
+{"abstract_id": "25002367", "label": "objective", "text": "A startling loud acoustic stimulus can involuntarily elicit planned movements , a phenomenon referred to as startReact .", "sentence_id": 0}
+{"abstract_id": "25002367", "label": "objective", "text": "Following stroke , startReact elbow flexion in stroke survivors are improved from voluntary movements .", "sentence_id": 1}
+{"abstract_id": "25002367", "label": "objective", "text": "Specifically , startReact elbow flexion in unimpaired individuals is not statistically different from stroke survivors in terms of onset latency and muscle activation patterns .", "sentence_id": 2}
+{"abstract_id": "25002367", "label": "objective", "text": "As hand movements are particularly impacted by stroke , our objective was to determine if startReact was intact in the hand following stroke .", "sentence_id": 3}
+{"abstract_id": "25002367", "label": "methods", "text": "Data were collected in @ stroke survivors and @ age-matched subjects performing hand extension following two non-startling acoustic stimuli representing `` get ready '' and `` go '' respectively .", "sentence_id": 4}
+{"abstract_id": "25002367", "label": "methods", "text": "Randomly , the `` go '' was replaced with a startling acoustic stimulus .", "sentence_id": 5}
+{"abstract_id": "25002367", "label": "methods", "text": "We hypothesized that ( @ ) startReact would be intact during hand extension in stroke survivors and that ( @ ) the latency of movement would be the same as in age-matched subjects .", "sentence_id": 6}
+{"abstract_id": "25002367", "label": "results", "text": "We found that startReact was intact in stroke subjects and further that the onset latency of these movements was not different from age-matched subjects .", "sentence_id": 7}
+{"abstract_id": "25002367", "label": "conclusions", "text": "We conclude that startReact is intact in the hand following stroke .", "sentence_id": 8}
+{"abstract_id": "25002367", "label": "conclusions", "text": "An intact startReact response indicates that this reflex may be an attractive therapeutic target for initiating hand extension in stroke survivors .", "sentence_id": 9}
+{"abstract_id": "25167350", "label": "background", "text": "One of the most challenging aspects of a revision knee arthroplasty is the management of bone loss .", "sentence_id": 0}
+{"abstract_id": "25167350", "label": "background", "text": "The OBJECTIVE of the study is to show the capability to augment bone mineral density in areas with bone loss with platelet-derived growth factors .", "sentence_id": 1}
+{"abstract_id": "25167350", "label": "methods", "text": "Randomized , prospective , blinded study in patients who underwent a total knee replacement revision with tibial-damaged metaphyseal bone were randomly allocated to have a revision total knee arthroplasty and to fill the bone defects with lyophilized bone allograft mixed with platelet growth factors ( experimental group , n = @ ) or with lyophilized bone allograft alone ( control group , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25167350", "label": "methods", "text": "To evaluate bone mineral density between groups , dual-energy X-ray absorptiometry ( DEXA ) was performed preoperatively , at @ month , @ months and @ year after surgery .", "sentence_id": 3}
+{"abstract_id": "25167350", "label": "results", "text": "The study was comprised of a total of @ patients .", "sentence_id": 4}
+{"abstract_id": "25167350", "label": "results", "text": "We found no significant differences observed during the follow-up between groups in mineral bone density .", "sentence_id": 5}
+{"abstract_id": "25167350", "label": "conclusions", "text": "Use of platelet-derived growth factors does not improve bone mineral density in patients with revision knee arthroplasty .", "sentence_id": 6}
+{"abstract_id": "24695894", "label": "background", "text": "The greater presence of supermarkets in low-income , high-minority neighborhoods has the potential to positively affect diet quality among those at greatest risk of obesity .", "sentence_id": 0}
+{"abstract_id": "24695894", "label": "background", "text": "In-store marketing strategies that draw attention to healthier products may be effective , sustainable , and scalable for improving diet quality and health .", "sentence_id": 1}
+{"abstract_id": "24695894", "label": "background", "text": "Few controlled studies of in-store marketing strategies to promote sales of healthier items in low-income , high-minority neighborhoods have been conducted .", "sentence_id": 2}
+{"abstract_id": "24695894", "label": "objective", "text": "The objective of this study was to evaluate the effects of in-store marketing strategies to promote the purchase of specific healthier items in @ product categories : milk , ready-to-eat cereal , frozen meals , in-aisle beverages , and checkout cooler beverages .", "sentence_id": 3}
+{"abstract_id": "24695894", "label": "methods", "text": "The design was a cluster-randomized controlled trial conducted from @ to @ .", "sentence_id": 4}
+{"abstract_id": "24695894", "label": "methods", "text": "Eight urban supermarkets in low-income , high-minority neighborhoods were the unit of randomization , intervention , and analysis .", "sentence_id": 5}
+{"abstract_id": "24695894", "label": "methods", "text": "Stores were matched on the percentage of sales from government food-assistance programs and store size and randomly assigned to an intervention or control group .", "sentence_id": 6}
+{"abstract_id": "24695894", "label": "methods", "text": "The @ intervention stores received a @-mo , in-store marketing intervention that promoted the sales of healthier products through placement , signage , and product availability strategies .", "sentence_id": 7}
+{"abstract_id": "24695894", "label": "methods", "text": "The @ control stores received no intervention and were assessment-only controls .", "sentence_id": 8}
+{"abstract_id": "24695894", "label": "methods", "text": "The main outcome measure was weekly sales of the targeted products , which was assessed on the basis of the stores ' sales data .", "sentence_id": 9}
+{"abstract_id": "24695894", "label": "results", "text": "Intervention stores showed significantly greater sales of skim and @ % milk , water ( in aisle and at checkout ) , and @ of @ types of frozen meals compared with control store sales during the same time period .", "sentence_id": 10}
+{"abstract_id": "24695894", "label": "results", "text": "No differences were found between the stores in sales of cereal , whole or @ % milk , beverages , or diet beverages .", "sentence_id": 11}
+{"abstract_id": "24695894", "label": "conclusions", "text": "These data indicate that straightforward placement strategies can significantly enhance the sales of healthier items in several food and beverage categories .", "sentence_id": 12}
+{"abstract_id": "24695894", "label": "conclusions", "text": "Such strategies show promise for significant public health effects in communities with the greatest risk of obesity .", "sentence_id": 13}
+{"abstract_id": "25573882", "label": "objective", "text": "This study examined the association between cardiac autonomic dysfunction and high albumin-to-creatinine ratio ( ACR ) in adolescents with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25573882", "label": "methods", "text": "Adolescents recruited as part of a multicenter screening study ( n = @ , @ % female , aged @-@ years , mean duration @ years ; mean HbA@c @ % , @ mmol/mol ) underwent a @-min continuous electrocardiogram recording for heart rate variability analysis .", "sentence_id": 1}
+{"abstract_id": "25573882", "label": "methods", "text": "Time-domain heart rate variability measures included baseline heart rate , SD of the R-R interval ( SDNN ) , and root mean squared difference of successive R-R intervals ( RMSSD ) .", "sentence_id": 2}
+{"abstract_id": "25573882", "label": "methods", "text": "Spectral analysis included sympathetic ( low-frequency ) and parasympathetic ( high-frequency ) components .", "sentence_id": 3}
+{"abstract_id": "25573882", "label": "methods", "text": "Standardized ACR were calculated from six early morning urine collections using an established algorithm , reflecting age , sex , and duration , and stratified into ACR tertiles , where the upper tertile reflects higher nephropathy risk .", "sentence_id": 4}
+{"abstract_id": "25573882", "label": "results", "text": "The upper-tertile ACR group had a faster heart rate ( @ vs. @ bpm ; P < @ ) and less heart rate variability ( SDNN @ vs. @ ms , P = @ ; RMSSD @ vs. @ ms , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25573882", "label": "results", "text": "HbA@c was @ % ( @ mmol/mmol ) in the upper tertile vs. @ % ( @ mmol/mol ) in the lower tertiles ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25573882", "label": "results", "text": "In multivariable analysis , upper-tertile ACR was associated with faster heart rate ( = @ , @ % CI @-@ @ , P = @ ) and lower RMSSD ( = -@ , @ % CI -@ to -@ , P = @ ) , independent of age and HbA@c .", "sentence_id": 7}
+{"abstract_id": "25573882", "label": "conclusions", "text": "Adolescents at potentially higher risk for nephropathy show an adverse cardiac autonomic profile , indicating sympathetic overdrive , compared with the lower-risk group .", "sentence_id": 8}
+{"abstract_id": "25573882", "label": "conclusions", "text": "Longitudinal follow-up of this cohort will further characterize the relationship between autonomic and renal dysfunction and the effect of interventions in this population .", "sentence_id": 9}
+{"abstract_id": "24296748", "label": "objective", "text": "According to mathematical modeling , intradialytic exercise of sufficient intensity and duration implemented in the second half of dialysis should be as efficacious as increasing dialysis time for dialysis adequacy .", "sentence_id": 0}
+{"abstract_id": "24296748", "label": "objective", "text": "This assumption has not been tested in vivo .", "sentence_id": 1}
+{"abstract_id": "24296748", "label": "methods", "text": "In this controlled trial , @ hemodialysis ( HD ) patients ( mean ( SD ) age @ ( @ ) years ) were recruited .", "sentence_id": 2}
+{"abstract_id": "24296748", "label": "methods", "text": "Each patient completed three trial arms in a randomized order : routine care ( CONT ) , increased HD time of @ min ( TIME ) , and intradialytic exercise ( EXER ) , @ min of cycling at @ % of the lactate threshold in the last @ min of HD .", "sentence_id": 3}
+{"abstract_id": "24296748", "label": "methods", "text": "The primary outcome was eKt/Vurea .", "sentence_id": 4}
+{"abstract_id": "24296748", "label": "methods", "text": "Secondary outcomes included reduction and rebound ratios of urea , creatinine , phosphate and @-microglobulin .", "sentence_id": 5}
+{"abstract_id": "24296748", "label": "methods", "text": "Outcomes were calculated from blood sampling collected pre - , post - and @ min post-HD and confirmed with dialysate sampling .", "sentence_id": 6}
+{"abstract_id": "24296748", "label": "results", "text": "Exercise was not as efficacious as increased HD time for eKt/Vurea ( EXER vs. CONT , mean change ( @ % CI ) : @ ( -@ to @ ) ; TIME vs. CONT : @ ( @-@ @ ) ) .", "sentence_id": 7}
+{"abstract_id": "24296748", "label": "results", "text": "Exercise was less efficacious at improving reduction ratios of urea and creatinine .", "sentence_id": 8}
+{"abstract_id": "24296748", "label": "results", "text": "However , exercise was more efficacious than increased dialysis time for phosphate reduction ratio ( EXER vs. CONT : @ % ( @-@ @ ) ; TIME vs. CONT : @ % ( -@ to @ ) ) .", "sentence_id": 9}
+{"abstract_id": "24296748", "label": "conclusions", "text": "This study utilized a rigorously controlled in vivo design to test mathematical models and assumptions regarding dialysis adequacy .", "sentence_id": 10}
+{"abstract_id": "24296748", "label": "conclusions", "text": "Intradialytic exercise towards the end of HD can not replace the prescription of increased HD time for dialysis adequacy , but may be an adjunctive therapy for serum phosphate control .", "sentence_id": 11}
+{"abstract_id": "24508475", "label": "background", "text": "Previous observational studies examining outcomes associated with the timing of dialysis therapy initiation in the United States have often been limited by lead time and survivor bias .", "sentence_id": 0}
+{"abstract_id": "24508475", "label": "methods", "text": "Retrospective cohort study comparing the effectiveness of early versus later ( conventional ) dialysis therapy initiation in advanced chronic kidney disease ( CKD ) .", "sentence_id": 1}
+{"abstract_id": "24508475", "label": "methods", "text": "The analysis used inverse probability weighting to account for an individual 's contribution to different exposure groups over time in a pooled logistic regression model .", "sentence_id": 2}
+{"abstract_id": "24508475", "label": "methods", "text": "Patients contributed risk to both exposure categories ( early and later initiation ) until there was a clear treatment strategy ( ie , dialysis therapy was initiated early or estimated glomerular filtration rate -LSB- eGFR -RSB- decreased to < @mL/min/@ @ m ( @ ) ) .", "sentence_id": 3}
+{"abstract_id": "24508475", "label": "methods", "text": "Patients with CKD who had at least one face-to-face outpatient encounter with a Cleveland Clinic health care provider as of January @ , @ , and at least @ eGFRs in the range of @-@mL / min/@ @ m ( @ ) measured at least @ days apart .", "sentence_id": 4}
+{"abstract_id": "24508475", "label": "methods", "text": "Timing of dialysis therapy initiation as determined using model-based interpolation of eGFR trajectories over time .", "sentence_id": 5}
+{"abstract_id": "24508475", "label": "methods", "text": "Timing was defined as early ( interpolated eGFR at dialysis therapy initiation@mL/min/@ @ m ( @ ) ) or later ( eGFR < @mL/min/@ @ m ( @ ) ) and was time-varying .", "sentence_id": 6}
+{"abstract_id": "24508475", "label": "results", "text": "Death from any cause occurring from the time that eGFR was equal to @mL/min/@ @ m ( @ ) through September @ , @ .", "sentence_id": 7}
+{"abstract_id": "24508475", "label": "results", "text": "The study population consisted of @ patients meeting inclusion criteria .", "sentence_id": 8}
+{"abstract_id": "24508475", "label": "results", "text": "Most ( @ % ) of the study population did not initiate dialysis therapy during follow-up .", "sentence_id": 9}
+{"abstract_id": "24508475", "label": "results", "text": "Patients who did not initiate dialysis therapy ( n = @ ) were older , more likely to be white , and had more favorable laboratory profiles than those who started dialysis therapy .", "sentence_id": 10}
+{"abstract_id": "24508475", "label": "results", "text": "Overall , @ initiated dialysis early and @ had eGFRs decrease to < @mL/min/@ @ m ( @ ) .", "sentence_id": 11}
+{"abstract_id": "24508475", "label": "results", "text": "Many participants ( n = @ ) were censored prior to attaining a clear treatment strategy and were considered undeclared .", "sentence_id": 12}
+{"abstract_id": "24508475", "label": "results", "text": "There was no statistically significant survival difference for the early compared with later initiation strategy ( OR , @ ; @ % CI , @-@ @ ) .", "sentence_id": 13}
+{"abstract_id": "24508475", "label": "conclusions", "text": "Interpolated eGFR , moderate sample size , and likely unmeasured confounders .", "sentence_id": 14}
+{"abstract_id": "24508475", "label": "conclusions", "text": "In patients with advanced CKD , timing of dialysis therapy initiation was not associated with mortality when accounting for lead time bias and survivor bias .", "sentence_id": 15}
+{"abstract_id": "24841015", "label": "background", "text": "Bianchi and Squire introduced single high trans-scrotal incision for mobilisation of palpable undescended testes to decrease the potential morbidity of the traditional inguinal approach .", "sentence_id": 0}
+{"abstract_id": "24841015", "label": "background", "text": "This incision has not gained widespread acceptance and there is still a considerable debate about its efficacy .", "sentence_id": 1}
+{"abstract_id": "24841015", "label": "background", "text": "This study evaluated the outcome of high single scrotal incision in comparison to the classic inguinal exploration for unilateral palpable testes regardless to its pre-operative location to assure its validity and safety .", "sentence_id": 2}
+{"abstract_id": "24841015", "label": "methods", "text": "This was a randomised controlled study conducted on seventy males with palpable unilateral undescended testicles from November @ to October @ .", "sentence_id": 3}
+{"abstract_id": "24841015", "label": "methods", "text": "They were divided into two equal groups ; group I had high single scrotal incision and group II had the classic inguinal approach .", "sentence_id": 4}
+{"abstract_id": "24841015", "label": "methods", "text": "The comparative parameters between both groups were the operative time , intra-and post-operative complications , post-operative pain and scar .", "sentence_id": 5}
+{"abstract_id": "24841015", "label": "results", "text": "There was statistical significant difference between both groups regarding the operative time ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24841015", "label": "results", "text": "The high scrotal approach ( Group I ) was not completed in three cases and were converted to the classic inguinal approach .", "sentence_id": 7}
+{"abstract_id": "24841015", "label": "results", "text": "No statistical significant difference between both groups regarding the post-operative complications .", "sentence_id": 8}
+{"abstract_id": "24841015", "label": "conclusions", "text": "Single high scrotal incision orchidopexy for palpable undescended testis is safe , has shorter operative time but may not be suitable for proximally lying testis .", "sentence_id": 9}
+{"abstract_id": "25578255", "label": "objective", "text": "Intravitreal antiangiogenic therapy is the major therapeutic breakthrough in neovascular age-related macular degeneration ( AMD ) .", "sentence_id": 0}
+{"abstract_id": "25578255", "label": "objective", "text": "Optical coherence tomography ( OCT ) is the leading diagnostic tool , but solid criteria for optimal therapeutic outcomes are lacking .", "sentence_id": 1}
+{"abstract_id": "25578255", "label": "objective", "text": "A comprehensive analysis of structure/function correlations using Food and Drug Administration - and European Medicines Agency-approved substances and fixed and flexible regimens was performed .", "sentence_id": 2}
+{"abstract_id": "25578255", "label": "methods", "text": "Post hoc analysis of a prospective , randomized multicenter clinical trial including @ study sites .", "sentence_id": 3}
+{"abstract_id": "25578255", "label": "methods", "text": "A total of @ patients with active neovascular AMD .", "sentence_id": 4}
+{"abstract_id": "25578255", "label": "methods", "text": "Participants received intravitreal ranibizumab or aflibercept .", "sentence_id": 5}
+{"abstract_id": "25578255", "label": "methods", "text": "A fixed regimen was used for @ weeks followed by a flexible regimen until week @ .", "sentence_id": 6}
+{"abstract_id": "25578255", "label": "methods", "text": "At monthly intervals , best-corrected visual acuity ( BCVA ) was measured and retinal morphology was assessed by standardized OCT , including intraretinal cysts ( IRCs ) , subretinal fluid ( SRF ) , and pigment epithelial detachment ( PED ) , presenting with a width @ m or a height of @ m. Results were correlated for each regimen , feature , and time .", "sentence_id": 7}
+{"abstract_id": "25578255", "label": "methods", "text": "The BCVA outcomes in relation to retinal pathomorphology based on noninferiority for all treatment arms .", "sentence_id": 8}
+{"abstract_id": "25578255", "label": "results", "text": "In neovascular AMD , only IRC at baseline and persistent through week @ had a negative impact on BCVA .", "sentence_id": 9}
+{"abstract_id": "25578255", "label": "results", "text": "With therapeutic intervention , exudative features such as IRC and SRF resolved rapidly in @ % of eyes , whereas PED responded only slowly with @ % .", "sentence_id": 10}
+{"abstract_id": "25578255", "label": "results", "text": "Independent of the type of regimen , fixed or flexible , retinal morphology correlated tightly with visual function .", "sentence_id": 11}
+{"abstract_id": "25578255", "label": "results", "text": "Intraretinal cysts consistently showed the lowest BCVA gains with either regimen or substance .", "sentence_id": 12}
+{"abstract_id": "25578255", "label": "results", "text": "With the switch from a fixed to a flexible pro re nata ( PRN ) regimen , progressive visual loss occurred exclusively in the group with primary PED presenting as the hallmark of neovascular activity and was induced by secondary formation of IRC in the neurosensory retina .", "sentence_id": 13}
+{"abstract_id": "25578255", "label": "conclusions", "text": "The efficacy of antiangiogenic therapy in neovascular AMD is strongly determined by morphologic features .", "sentence_id": 14}
+{"abstract_id": "25578255", "label": "conclusions", "text": "The subretinal pigment epithelium lesion underlying PED appears to be the primary indicator for progressive disease activity , whereas secondary cystoid degeneration is the most relevant imaging marker for visual function .", "sentence_id": 15}
+{"abstract_id": "25578255", "label": "conclusions", "text": "Clinically , PED emerged as trigger for consecutive vision loss in PRN treatment .", "sentence_id": 16}
+{"abstract_id": "24690511", "label": "background", "text": "The present article presents the protocol for a randomised controlled trial to test the effectiveness of a group-based self-management support programme for recently diagnosed type @ diabetes mellitus ( T@DM ) patients ( one to three years post-diagnosis ) and their partners .", "sentence_id": 0}
+{"abstract_id": "24690511", "label": "background", "text": "The course aims to support T@DM patients and their partners in successfully integrating diabetes care into their daily lives and hereby enhance self-management and diabetes-specific health-related quality of life .", "sentence_id": 1}
+{"abstract_id": "24690511", "label": "background", "text": "The content of the course is based on the Common-Sense Model of Self-Regulation ( CSM ) .", "sentence_id": 2}
+{"abstract_id": "24690511", "label": "background", "text": "Furthermore , principles from the Social Cognitive Theory ( SCT ) and social support theories are integrated .", "sentence_id": 3}
+{"abstract_id": "24690511", "label": "methods", "text": "We aim to recruit @ recently diagnosed T@DM patients and their partners from general practices in six different regions in the Netherlands .", "sentence_id": 4}
+{"abstract_id": "24690511", "label": "methods", "text": "Patients need to be diagnosed with T@DM for one to three years and have to experience some degree of diabetes-related difficulties , as measured with a three-item screener .", "sentence_id": 5}
+{"abstract_id": "24690511", "label": "methods", "text": "Participating patients and their partners are randomly allocated to the intervention or control condition .", "sentence_id": 6}
+{"abstract_id": "24690511", "label": "methods", "text": "Participants in the intervention condition receive three monthly group sessions and a booster session three months later .", "sentence_id": 7}
+{"abstract_id": "24690511", "label": "methods", "text": "Participants in the control condition receive a single information meeting .", "sentence_id": 8}
+{"abstract_id": "24690511", "label": "methods", "text": "Data will be collected at baseline ( T@ ) , directly after the programme ( T@ ) and six months post-programme ( T@ ) , including : self-management , diabetes-specific health-related quality of life , illness perceptions , attitudes , social support and empowerment .", "sentence_id": 9}
+{"abstract_id": "24690511", "label": "methods", "text": "A three-level multilevel model will be used to compare change-scores between the conditions ( intervention/control ) on each outcome .", "sentence_id": 10}
+{"abstract_id": "24690511", "label": "conclusions", "text": "Our study will be the first to determine whether a group-based support programme based on the CSM is effective in enhancing self-management and diabetes-specific health-related quality of life in recently diagnosed T@DM patients .", "sentence_id": 11}
+{"abstract_id": "24690511", "label": "conclusions", "text": "The important role of patients ' partners in effective diabetes care is also acknowledged in the study .", "sentence_id": 12}
+{"abstract_id": "24262278", "label": "objective", "text": "We evaluated an all-oral regimen comprising the nucleotide polymerase inhibitor sofosbuvir ( SOF ) with the NS@A inhibitor ledipasvir ( LDV ) or the NS@B non-nucleoside inhibitor GS-@ in patients with genotype @ hepatitis C virus ( HCV ) infection .", "sentence_id": 0}
+{"abstract_id": "24262278", "label": "methods", "text": "A total of @ patients were enrolled .", "sentence_id": 1}
+{"abstract_id": "24262278", "label": "methods", "text": "Sofosbuvir ( @ mg once daily ) and LDV ( @ mg once daily ) plus ribavirin ( RBV ) were given for @ weeks to treatment-nave ( TN ) patients ( n = @ ) and those who did not respond to previous therapy ( prior null responders , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24262278", "label": "methods", "text": "Sofosbuvir and GS-@ ( @ mg once daily ) plus RBV were given for @ weeks to TN patients ( n = @ ) and prior null responders ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24262278", "label": "methods", "text": "Additionally , prior null responders with cirrhosis were randomly assigned to groups given a fixed-dose combination of SOF and LDV , with RBV ( n = @ ) or without RBV ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24262278", "label": "methods", "text": "Finally , a group of TN patients received SOF , LDV , and RBV for @ weeks ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24262278", "label": "methods", "text": "The primary efficacy end point was sustained virologic response @ weeks after therapy ( SVR@ ) .", "sentence_id": 6}
+{"abstract_id": "24262278", "label": "results", "text": "SVR@ was achieved by @ of @ ( @ % ) TN patients receiving SOF , LDV , and RBV and @ of @ ( @ % ) of those receiving SOF , GS-@ , and RBV .", "sentence_id": 7}
+{"abstract_id": "24262278", "label": "results", "text": "Of TN patients receiving @ weeks of SOF , LDV , and RBV , @ of @ ( @ % ) achieved SVR@ .", "sentence_id": 8}
+{"abstract_id": "24262278", "label": "results", "text": "All noncirrhotic prior null responders receiving @ weeks of SOF along with another direct-acting antiviral agent plus RBV achieved SVR@-@ of @ ( @ % ) of those receiving SOF , LDV , and RBV and @ of @ ( @ % ) of those receiving SOF , GS-@ , and RBV .", "sentence_id": 9}
+{"abstract_id": "24262278", "label": "results", "text": "Among cirrhotic prior null responders , SVR@ was achieved by @ ( @ % ) of those receiving SOF , LDV , and RBV and @ ( @ % ) of those receiving SOF and LDVD without RBV .", "sentence_id": 10}
+{"abstract_id": "24262278", "label": "results", "text": "The most common reported adverse events were headache , fatigue , and nausea .", "sentence_id": 11}
+{"abstract_id": "24262278", "label": "conclusions", "text": "The combination of SOF and a second direct-acting antiviral agent is highly effective in TN patients with HCV genotype @ infection and in patients that did not respond to previous treatment .", "sentence_id": 12}
+{"abstract_id": "24262278", "label": "conclusions", "text": "ClinicalTrials.gov ID NCT@ .", "sentence_id": 13}
+{"abstract_id": "25077855", "label": "objective", "text": "Religious involvement may help individuals with chronic medical illness cope better with physical disability and other life changes .", "sentence_id": 0}
+{"abstract_id": "25077855", "label": "objective", "text": "We examine the relationships between religiosity , depressive symptoms , and positive emotions in persons with major depression and chronic illness .", "sentence_id": 1}
+{"abstract_id": "25077855", "label": "methods", "text": "@ persons who were at least somewhat religious/spiritual were recruited into a clinical trial to evaluate the effectiveness of religious vs. secular cognitive behavioral therapy .", "sentence_id": 2}
+{"abstract_id": "25077855", "label": "methods", "text": "Reported here are the relationships at baseline between religious involvement and depressive symptoms , purpose in life , optimism , generosity , and gratefulness using standard measures .", "sentence_id": 3}
+{"abstract_id": "25077855", "label": "results", "text": "Although religiosity was unrelated to depressive symptoms ( F = @ , p = @ ) and did not buffer the disability-depression relationship ( B = -@ , SE @ , p = @ ) , strong relationships were found between religious indicators and greater purpose , optimism , generosity , and gratefulness ( F = @ , p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25077855", "label": "conclusions", "text": "Although unrelated to depressive symptoms in the setting of major depression and chronic medical illness , higher religious involvement is associated with positive emotions , a finding which may influence the course of depression over time .", "sentence_id": 5}
+{"abstract_id": "25626984", "label": "objective", "text": "Sleep and ongoing cycling of sleep states are required for neurosensory processing , learning , and brain plasticity .", "sentence_id": 0}
+{"abstract_id": "25626984", "label": "objective", "text": "Many aspects of neonatal intensive care environments such as handling for routine and invasive procedures , bright lighting , and noise can create stress , disrupt behavior , and interfere with sleep in prematurely born infants .", "sentence_id": 1}
+{"abstract_id": "25626984", "label": "objective", "text": "The study empirically investigated whether a @-minute observation of infant sleep states and behavior could differentiate an intervention to promote sleep in premature infants with feeding difficulties relative to conventional care ( standard positioning , standard crib mattress -LSB- SP -RSB- ) .", "sentence_id": 2}
+{"abstract_id": "25626984", "label": "objective", "text": "We included an intervention to determine the ability of the method to discriminate treatments and generate a benchmark for future improvements .", "sentence_id": 3}
+{"abstract_id": "25626984", "label": "objective", "text": "The intervention , a conformational positioner ( CP ) , is contoured around the infant to provide customized containment and boundaries .", "sentence_id": 4}
+{"abstract_id": "25626984", "label": "objective", "text": "To more fully verify the @-minute observational sleep results , standard polysomnography was conducted simultaneously and sleep outcomes for the @ modalities were compared .", "sentence_id": 5}
+{"abstract_id": "25626984", "label": "methods", "text": "In a randomized crossover clinical trial , @ infants , @ @ weeks ' gestational age and @ @ weeks at the study , with gastrointestinal conditions or general feeding difficulties used each intervention during an overnight neonatal intensive care unit sleep study .", "sentence_id": 6}
+{"abstract_id": "25626984", "label": "methods", "text": "Infant sleep states and behaviors were observed during two @-minute periods -- that is , on the positioner and mattress -- using the naturalistic observation of newborn behavior .", "sentence_id": 7}
+{"abstract_id": "25626984", "label": "methods", "text": "Two certified developmental care nurses assessed sleep state , self-regulatory , and stress behaviors during @-minute intervals and summed over @ minutes .", "sentence_id": 8}
+{"abstract_id": "25626984", "label": "methods", "text": "Sleep characteristics from standard polysomnography were measured at the time of behavior observations .", "sentence_id": 9}
+{"abstract_id": "25626984", "label": "results", "text": "Infants on CP spent significantly less time in alert , active awake , or crying states by observation compared with SP .", "sentence_id": 10}
+{"abstract_id": "25626984", "label": "results", "text": "Surgical subjects spent more time awake , active awake , or crying and displayed a higher number of behavior state changes than the nonsurgical infants .", "sentence_id": 11}
+{"abstract_id": "25626984", "label": "results", "text": "The percentage of time in observed deep sleep and quiet sleep was correlated with both percentage sleep efficiency ( r = @ ) and fewer state shifts per hour ( r = -@ ) from electroencephalogram ( EEG ) .", "sentence_id": 12}
+{"abstract_id": "25626984", "label": "results", "text": "Sleep efficiency by EEG was greater on CP versus SP .", "sentence_id": 13}
+{"abstract_id": "25626984", "label": "conclusions", "text": "The CP enabled sleep compared with the standard mattress ( SP ) over @-minute observation periods .", "sentence_id": 14}
+{"abstract_id": "25626984", "label": "conclusions", "text": "Sleep status from behavioral observation was verified by standard EEG-based sleep techniques .", "sentence_id": 15}
+{"abstract_id": "25626984", "label": "conclusions", "text": "Behavioral observation of sleep states may be a useful strategy for measuring the effectiveness of strategies to facilitate sleep in premature infants .", "sentence_id": 16}
+{"abstract_id": "25626984", "label": "conclusions", "text": "Surgical subjects may benefit from additional interventions to promote sleep .", "sentence_id": 17}
+{"abstract_id": "25574983", "label": "background", "text": "Bronchiolitis is a common clinical problem in children below @ years presenting with respiratory symptoms .", "sentence_id": 0}
+{"abstract_id": "25574983", "label": "background", "text": "As there is necrosis and sloughing of epithelial cells , edema , increased secretion of mucus causing obstruction of large and small airways we aim to see the clinical profile and the effect of use of hypertonic ( @ % ) saline nebulization in these children .", "sentence_id": 1}
+{"abstract_id": "25574983", "label": "methods", "text": "A double blind randomized controlled trial was conducted at department of Pediatrics , in a hospital from July @ to August @ .", "sentence_id": 2}
+{"abstract_id": "25574983", "label": "methods", "text": "The computer generated random number was used to select the case and control group .", "sentence_id": 3}
+{"abstract_id": "25574983", "label": "methods", "text": "All eligible patients were randomly assigned to one of two groups : receiving inhalation of @ ml normal ( @ % ) saline or hypertonic ( @ % ) saline .", "sentence_id": 4}
+{"abstract_id": "25574983", "label": "methods", "text": "Treating physicians , researchers and nurses were all blinded of the solution .", "sentence_id": 5}
+{"abstract_id": "25574983", "label": "methods", "text": "Both saline were kept in two identical containers and labeled as solution A and solution B. Patients in each group will receive three treatments on each day of hospitalization and clinical score were obtained @ minutes before each inhalation session .", "sentence_id": 6}
+{"abstract_id": "25574983", "label": "results", "text": "Bronchiolitis accounted @ % of total admissions .", "sentence_id": 7}
+{"abstract_id": "25574983", "label": "results", "text": "Their mean age ( SD ) was @ ( @ ) months with range from @ days to @ months .", "sentence_id": 8}
+{"abstract_id": "25574983", "label": "results", "text": "A total of @ ( @ % ) male were enrolled in the study .", "sentence_id": 9}
+{"abstract_id": "25574983", "label": "results", "text": "Fifty-seven ( @ % ) children were less than @ months and @ ( @ % ) were @ months - @ months .", "sentence_id": 10}
+{"abstract_id": "25574983", "label": "results", "text": "The mean ( SD ) for duration of hospital stay was @ ( @ ) and @ ( @ ) for @ % and @ % group respectively ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25574983", "label": "results", "text": "Likewise , mean ( SD ) duration of oxygen supplementation was @ ( @ ) and @ ( @ ) for @ % and @ % group respectively ( p = @ ) .", "sentence_id": 12}
+{"abstract_id": "25574983", "label": "results", "text": "Moreover , time required for normalization of clinical score was @ ( @ ) and @ ( @ ) for @ % and @ % group respectively ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "25574983", "label": "conclusions", "text": "There is no advantage of hypertonic saline over normal saline nebulization in the management bronchiolitis .", "sentence_id": 14}
+{"abstract_id": "25511923", "label": "background", "text": "The IFCT-GFPC @ phase III study reported prolongation of progression-free survival with gemcitabine or erlotinib maintenance vs. observation after cisplatin-gemcitabine induction chemotherapy for advanced non-small-cell lung cancer ( NSCLC ) .", "sentence_id": 0}
+{"abstract_id": "25511923", "label": "background", "text": "This analysis was undertaken to assess the incremental cost-effectiveness ratio ( ICER ) of these strategies for the global population and pre-specified subgroups .", "sentence_id": 1}
+{"abstract_id": "25511923", "label": "methods", "text": "A cost-utility analysis evaluated the ICER of gemcitabine or erlotinib maintenance therapy vs. observation , from randomization until the end of follow-up .", "sentence_id": 2}
+{"abstract_id": "25511923", "label": "methods", "text": "Direct medical costs ( including drugs , hospitalization , follow-up examinations , second-line treatments and palliative care ) were prospectively collected per patient during the trial , until death , from the primary health-insurance provider 's perspective .", "sentence_id": 3}
+{"abstract_id": "25511923", "label": "methods", "text": "Utility data were extracted from literature .", "sentence_id": 4}
+{"abstract_id": "25511923", "label": "methods", "text": "Sensitivity analyses were conducted .", "sentence_id": 5}
+{"abstract_id": "25511923", "label": "results", "text": "The ICERs for gemcitabine or erlotinib maintenance therapy were respectively @,@ and @,@ euros per quality-adjusted life year ( QALY ) .", "sentence_id": 6}
+{"abstract_id": "25511923", "label": "results", "text": "Gemcitabine continuation maintenance therapy had a favourable ICER in patients with PS = @ ( @,@ / QALY ) , in responders to induction chemotherapy ( @,@ / QALY ) , regardless of histology ( adenocarcinoma , @,@ / QALY , non adenocarcinoma , @,@ / QALY ) .", "sentence_id": 7}
+{"abstract_id": "25511923", "label": "results", "text": "Erlotinib maintenance showed a favourable ICER in patients with PS = @ ( @,@ / QALY ) , in patients with adenocarcinoma ( @,@ / QALY ) and in patient with objective response to induction ( @,@ / QALY ) , but it is not cost-effective in patients with PS = @ , in patients with non-adenocarcinoma or with stable disease after induction chemotherapy .", "sentence_id": 8}
+{"abstract_id": "25511923", "label": "conclusions", "text": "Gemcitabine - or erlotinib-maintenance therapy had ICERs that varied as a function of histology , PS and response to first-line chemotherapy .", "sentence_id": 9}
+{"abstract_id": "25417775", "label": "background", "text": "Bevacizumab is associated with an increased risk of arterial thromboembolism ( ATE ) ; however , its effect on venous thromboembolism ( VTE ) remains controversial .", "sentence_id": 0}
+{"abstract_id": "25417775", "label": "background", "text": "Scant data exist on the factors that increase the risk of ATE/VTE in patients with prostate cancer .", "sentence_id": 1}
+{"abstract_id": "25417775", "label": "background", "text": "The authors investigated the association of bevacizumab treatment and clinical factors with ATE/VTE risk in patients who were treated on Cancer and Leukemia Group B ( CALGB ) trial @ .", "sentence_id": 2}
+{"abstract_id": "25417775", "label": "methods", "text": "Patients with metastatic , castration-resistant prostate cancer were randomized to receive docetaxel and prednisone with or without bevacizumab once every @ days .", "sentence_id": 3}
+{"abstract_id": "25417775", "label": "methods", "text": "Cycle-to-event Cox regression models were used to investigate the association of bevacizumab with the incidence of grade @ or greater ( @ ) ATE and VTE .", "sentence_id": 4}
+{"abstract_id": "25417775", "label": "methods", "text": "Age , prior ATE/VTE , baseline antiplatelet/anticoagulant use , and VTE risk score ( based on leukocyte count , hemoglobin , platelet count , body mass index , and tumor location ) were evaluated in univariate and multivariable analyses .", "sentence_id": 5}
+{"abstract_id": "25417775", "label": "results", "text": "Of @ randomized patients , the odds of experiencing grade @ ATE were significantly greater in those who received bevacizumab compared with those who received placebo ( odds ratio , @ ; P = @ ) , whereas an opposite trend was noted for grade @ VTE ( odds ratio , @ ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25417775", "label": "results", "text": "In the multivariable analysis , bevacizumab treatment ( hazard ratio -LSB- HR -RSB- , @ ; P = @ ) and age ( HR , @ ; P = @ ) were significantly associated with the risk of ATE ; whereas age ( HR , @ ; P = @ ) and VTE risk score ( HR , @ ; P = @ ) were significantly associated with the risk of VTE .", "sentence_id": 7}
+{"abstract_id": "25417775", "label": "conclusions", "text": "Bevacizumab was significantly associated with a greater risk of ATE in patients with metastatic , castration-resistant prostate cancer , but it was not significantly associated with the risk of VTE .", "sentence_id": 8}
+{"abstract_id": "25417775", "label": "conclusions", "text": "Understanding clinical factors that increase the risk for experiencing ATE/VTE is essential to mitigate the risks and reduce the burden of these prevalent complications in cancer care .", "sentence_id": 9}
+{"abstract_id": "24703512", "label": "background", "text": "Previous studies have reported that stretching of the calf musculature and the plantar fascia are effective management strategies for plantar heel pain ( PHP ) .", "sentence_id": 0}
+{"abstract_id": "24703512", "label": "background", "text": "However , it is unclear whether myofascial release ( MFR ) can improve the outcomes in this population .", "sentence_id": 1}
+{"abstract_id": "24703512", "label": "objective", "text": "To investigate whether myofascial release ( MFR ) reduces the pain and functional disability associated with plantar heel pain ( PHP ) in comparison with a control group receiving sham ultrasound therapy ( SUST ) .", "sentence_id": 2}
+{"abstract_id": "24703512", "label": "methods", "text": "Randomized , controlled , double blinded trial .", "sentence_id": 3}
+{"abstract_id": "24703512", "label": "methods", "text": "Nonprofit research foundation clinic in India .", "sentence_id": 4}
+{"abstract_id": "24703512", "label": "methods", "text": "Sixty-six patients , @ men and @ women with a clinical diagnosis of PHP were randomly assigned into MFR or a control group and given @ sessions of treatment per client over @ weeks .", "sentence_id": 5}
+{"abstract_id": "24703512", "label": "methods", "text": "The Foot Function Index ( FFI ) scale was used to assess pain severity and functional disability .", "sentence_id": 6}
+{"abstract_id": "24703512", "label": "methods", "text": "The primary outcome measure was the difference in FFI scale scores between week @ ( pretest score ) , week @ ( posttest score ) , and follow-up at week @ after randomization .", "sentence_id": 7}
+{"abstract_id": "24703512", "label": "methods", "text": "Additionally , pressure pain thresholds ( PPT ) were assessed over the affected gastrocnemii and soleus muscles , and over the calcaneus , by an assessor blinded to the treatment allocation .", "sentence_id": 8}
+{"abstract_id": "24703512", "label": "results", "text": "The simple main effects analysis showed that the MFR group performed better than the control group in weeks @ and @ ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24703512", "label": "results", "text": "Patients in the MFR and control groups reported a @ % and @ % reduction , respectively , in their pain and functional disability in week @ compared with that in week @ , which persisted as @ % in the follow-up at week @ in the MFR group compared to the baseline .", "sentence_id": 10}
+{"abstract_id": "24703512", "label": "results", "text": "The mixed ANOVA also revealed significant group-by-time interactions for changes in PPT over the gastrocnemii and soleus muscles , and the calcaneus ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24703512", "label": "conclusions", "text": "This study provides evidence that MFR is more effective than a control intervention for PHP .", "sentence_id": 12}
+{"abstract_id": "25171125", "label": "objective", "text": "To evaluate the safety and effectiveness of radiofrequency dissection in conventional ` open ' total thyroidectomy .", "sentence_id": 0}
+{"abstract_id": "25171125", "label": "methods", "text": "Thirty-nine patients scheduled for conventional total thyroidectomy were included in a prospective randomised study .", "sentence_id": 1}
+{"abstract_id": "25171125", "label": "methods", "text": "Patients were randomly assigned to one of two groups : a radiofrequency dissection method was used in one group , and a knot tying technique was used in the other .", "sentence_id": 2}
+{"abstract_id": "25171125", "label": "results", "text": "Significantly fewer surgical instruments and materials were required for the radiofrequency dissection group than the knot tying group ( p < @ ) .", "sentence_id": 3}
+{"abstract_id": "25171125", "label": "results", "text": "There were no significant differences between the two groups in mean operative time , blood loss , post-operative drainage and pain , recurrent palsy , and hypocalcaemia ( p > @ ) .", "sentence_id": 4}
+{"abstract_id": "25171125", "label": "conclusions", "text": "Radiofrequency dissection is a safe alternative to the knot tying technique , and enables a significant reduction in the number of surgical instruments required for the operation .", "sentence_id": 5}
+{"abstract_id": "24330605", "label": "background", "text": "Lactose intolerance ( LI ) is a common medical problem with limited treatment options .", "sentence_id": 0}
+{"abstract_id": "24330605", "label": "background", "text": "The primary symptoms are abdominal pain , diarrhea , bloating , flatulence , and cramping .", "sentence_id": 1}
+{"abstract_id": "24330605", "label": "background", "text": "Limiting dairy foods to reduce symptoms contributes to low calcium intake and the risk for chronic disease .", "sentence_id": 2}
+{"abstract_id": "24330605", "label": "background", "text": "Adaptation of the colon bacteria to effectively metabolize lactose is a novel and potentially useful approach to improve lactose digestion and tolerance .", "sentence_id": 3}
+{"abstract_id": "24330605", "label": "background", "text": "RP-G@ is novel galacto-oligosaccharide ( GOS ) being investigated to improve lactose digestion and the symptoms of lactose intolerance in affected patients .", "sentence_id": 4}
+{"abstract_id": "24330605", "label": "methods", "text": "A randomized , double-blind , parallel group , placebo-controlled study was conducted at @ sites in the United States .", "sentence_id": 5}
+{"abstract_id": "24330605", "label": "methods", "text": "RP-G@ or placebo was administered to @ patients with LI for @ days .", "sentence_id": 6}
+{"abstract_id": "24330605", "label": "methods", "text": "Post-treatment , subjects reintroduced dairy into their daily diets and were followed for @ additional days to evaluate lactose digestion as measured by hydrogen production and symptom improvements via a patient-reported symptom assessment instrument .", "sentence_id": 7}
+{"abstract_id": "24330605", "label": "results", "text": "Lactose digestion and symptoms of LI trended toward improvement on RP-G@ at the end of treatment and @ days post-treatment .", "sentence_id": 8}
+{"abstract_id": "24330605", "label": "results", "text": "A reduction in abdominal pain was also demonstrated in the study results .", "sentence_id": 9}
+{"abstract_id": "24330605", "label": "results", "text": "Fifty percent of RP-G@ subjects with abdominal pain at baseline reported no abdominal pain at the end of treatment and @ days post treatment ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24330605", "label": "results", "text": "RP-G@ subjects were also six times more likely to claim lactose tolerance post-treatment once dairy foods had been re-introduced into their diets ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24330605", "label": "conclusions", "text": "Efficacy trends and favorable safety/tolerability findings suggest that RP-G@ appears to be a potentially useful approach for improving lactose digestion and LI symptoms .", "sentence_id": 12}
+{"abstract_id": "24330605", "label": "conclusions", "text": "The concurrent reduction in abdominal pain and improved overall tolerance could be a meaningful benefit to lactose intolerant individuals .", "sentence_id": 13}
+{"abstract_id": "25091062", "label": "objective", "text": "Helicobacter pylori eradication rates with clarithromycin-based triple therapy are declining , and an alternative strategy is needed urgently .", "sentence_id": 0}
+{"abstract_id": "25091062", "label": "objective", "text": "We sought to compare the efficacy of pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therapy for H. pylori eradication in a region with high rates of multiple drug resistance .", "sentence_id": 1}
+{"abstract_id": "25091062", "label": "methods", "text": "Consecutive H. pylori-infected patients with gastric epithelial neoplasms were randomized to receive antimicrobial susceptibility-guided therapy or clarithromycin-based triple therapy for @ days .", "sentence_id": 2}
+{"abstract_id": "25091062", "label": "methods", "text": "In patients in whom the infection was not eradicated , antibiotics were given according to an initial antimicrobial susceptibility test as a second-line therapy in both groups .", "sentence_id": 3}
+{"abstract_id": "25091062", "label": "methods", "text": "Eradication rates , antibiotics resistance rates , and drug compliance owing to adverse effects were compared between the groups .", "sentence_id": 4}
+{"abstract_id": "25091062", "label": "results", "text": "In total , @ patients were enrolled , and @ completed the protocols .", "sentence_id": 5}
+{"abstract_id": "25091062", "label": "results", "text": "Drug compliance and side effects were similar between the groups .", "sentence_id": 6}
+{"abstract_id": "25091062", "label": "results", "text": "The intention-to-treat eradication rates were @ % ( @ % confidence interval ( CI ) = @-@ % , @/@ ) in the antimicrobial susceptibility-guided group and @ % ( @ % CI = @-@ @ % , @/@ ) in the clarithromycin-based triple therapy group after the initial treatment ( P = @ ) , whereas the per-protocol ( PP ) eradication rates were @ % ( @ % CI = @-@ % , @/@ ) in the antimicrobial susceptibility-guided group and @ % ( @ % CI = @-@ @ % , @/@ ) in the clarithromycin-based triple therapy group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25091062", "label": "results", "text": "In H. pylori with clarithromycin resistance , the eradication failure rate with first-line treatment was lower in the susceptibility-guided therapy group ( @ % , @/@ ) compared with the clarithromycin-based triple therapy group ( @ % , @ % CI = @-@ % , @/@ ) by PP analysis ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25091062", "label": "conclusions", "text": "Pretreatment antimicrobial susceptibility-guided therapy is more effective than clarithromycin-based triple therapy for H. pylori eradication in a region with high rates of multiple drug resistance .", "sentence_id": 9}
+{"abstract_id": "25518878", "label": "background", "text": "Persons with a mental health diagnosis have high rates of tobacco use and face numerous barriers to cessation including high levels of nicotine dependence , low rates of tobacco treatment referrals from mental health providers , and limited availability of tobacco treatment targeted to their needs .", "sentence_id": 0}
+{"abstract_id": "25518878", "label": "background", "text": "This manuscript describes the rationale and methods of a clinical trial with the following aims : @ ) Compare the reach and efficacy of a proactive telephone-based tobacco cessation program for Veterans Health Administration ( VHA ) mental health clinic patients to VHA usual care and @ ) Model longitudinal associations between baseline patient characteristics and long-term abstinence .", "sentence_id": 1}
+{"abstract_id": "25518878", "label": "methods", "text": "We will use the electronic medical record to identify patients across four VHA healthcare facilities who have a clinical reminder code indicating current tobacco use in the past six months and who have had a mental health clinic visit in the past @ months .", "sentence_id": 2}
+{"abstract_id": "25518878", "label": "methods", "text": "We will send each patient an introductory letter and baseline survey .", "sentence_id": 3}
+{"abstract_id": "25518878", "label": "methods", "text": "Survey respondents ( N = @ ) will be randomized in a @:@ fashion to intervention or control .", "sentence_id": 4}
+{"abstract_id": "25518878", "label": "methods", "text": "Control participants will receive VHA usual care .", "sentence_id": 5}
+{"abstract_id": "25518878", "label": "methods", "text": "Intervention participants will receive proactive motivational telephone outreach to offer tobacco treatment .", "sentence_id": 6}
+{"abstract_id": "25518878", "label": "methods", "text": "Intervention participants interested in treatment will receive eight weeks of nicotine replacement therapy plus eight sessions of specialized telephone counseling over two months , followed by monthly maintenance counseling for four months .", "sentence_id": 7}
+{"abstract_id": "25518878", "label": "methods", "text": "We will conduct telephone surveys with participants at six and @ months to assess study outcomes .", "sentence_id": 8}
+{"abstract_id": "25518878", "label": "methods", "text": "We will collect a mailed saliva sample from patients reporting @-day abstinence on the telephone surveys .", "sentence_id": 9}
+{"abstract_id": "25518878", "label": "methods", "text": "The primary outcome will be cotinine-validated abstinence at @-month follow-up .", "sentence_id": 10}
+{"abstract_id": "25518878", "label": "conclusions", "text": "Mental health patients are a high-risk smoking population with significant barriers to cessation .", "sentence_id": 11}
+{"abstract_id": "25518878", "label": "conclusions", "text": "This study will evaluate the efficacy of a program that proactively reaches out to smokers with a mental health treatment history to engage them into telephone cessation counseling targeted to the needs of mental health patients .", "sentence_id": 12}
+{"abstract_id": "25456368", "label": "background", "text": "An effective and well tolerated treatment is needed for patients with early HER@-positive breast cancer who do not achieve a pathological complete response after neoadjuvant therapy .", "sentence_id": 0}
+{"abstract_id": "25456368", "label": "background", "text": "The AVATAXHER trial aimed to predict pathological complete response early with the use of PET and to investigate whether the addition of bevacizumab could improve the proportion of patients achieving a pathological complete response in patients unlikely to respond to treatment .", "sentence_id": 1}
+{"abstract_id": "25456368", "label": "methods", "text": "AVATAXHER was a randomised , open-label , non-comparative , multicentre phase @ study that enrolled women ( @ years of age ) with early-stage HER@-positive breast cancer from @ oncology centres in France .", "sentence_id": 2}
+{"abstract_id": "25456368", "label": "methods", "text": "Patients initially received two cycles of neoadjuvant docetaxel ( @ mg/m ( @ ) intravenously every @ weeks ) plus trastuzumab ( @ mg/kg intravenously every @ weeks then @ mg/kg intravenously every @ weeks for the second course ) .", "sentence_id": 3}
+{"abstract_id": "25456368", "label": "methods", "text": "Before the first and second cycles , -LSB- ( @ ) F -RSB- - fluorodeoxyglucose ( FDG ) PET was done and the change in standardised uptake value was used to predict pathological complete response in each patient .", "sentence_id": 4}
+{"abstract_id": "25456368", "label": "methods", "text": "Patients who were predicted to be responders on PET continued to receive standard therapy .", "sentence_id": 5}
+{"abstract_id": "25456368", "label": "methods", "text": "Predicted non-responders were randomly assigned ( @:@ ) to receive four cycles of docetaxel ( @ mg/m ( @ ) intravenously every @ weeks ) and trastuzumab ( @ mg/kg intravenously every @ weeks ) plus bevacizumab ( @ mg/kg intravenously every @ weeks ; group A ) or continue on docetaxel plus trastuzumab alone ( group B ) .", "sentence_id": 6}
+{"abstract_id": "25456368", "label": "methods", "text": "Randomisation was open label and was done by an adaptive minimisation method .", "sentence_id": 7}
+{"abstract_id": "25456368", "label": "methods", "text": "Although investigators and patients were aware of group assignment , the anatomo-pathologist in charge of centralised review of surgical samples and lymph nodes was masked to treatment assignment .", "sentence_id": 8}
+{"abstract_id": "25456368", "label": "methods", "text": "The primary endpoint was centrally assessed pathological complete response according to the Chevallier classification .", "sentence_id": 9}
+{"abstract_id": "25456368", "label": "methods", "text": "Efficacy analyses were done in the intention-to-treat population .", "sentence_id": 10}
+{"abstract_id": "25456368", "label": "methods", "text": "Safety analyses in this Article were done on all patients who received at least one dose of treatment starting from cycle @ .", "sentence_id": 11}
+{"abstract_id": "25456368", "label": "methods", "text": "Survival outcomes are not yet mature .", "sentence_id": 12}
+{"abstract_id": "25456368", "label": "methods", "text": "This study is registered with ClinicalTrials.gov ( NCT@ ) and EUDRACT ( @-@-@ ) .", "sentence_id": 13}
+{"abstract_id": "25456368", "label": "results", "text": "Between May @ , @ , and Oct @ , @ , @ patients were recruited for the study .", "sentence_id": 14}
+{"abstract_id": "25456368", "label": "results", "text": "Ten patients were subsequently excluded , leaving @ patients in the intention-to-treat population .", "sentence_id": 15}
+{"abstract_id": "25456368", "label": "results", "text": "Of these @ patients , @ were predicted by -LSB- ( @ ) F -RSB- - FDG PET to be treatment responders after two cycles of treatment .", "sentence_id": 16}
+{"abstract_id": "25456368", "label": "results", "text": "The @ predicted non-responders were randomly assigned to group A ( n = @ ) and group B ( n = @ ) .", "sentence_id": 17}
+{"abstract_id": "25456368", "label": "results", "text": "Pathological complete responses were noted in @ ( @ % , @ % CI @-@ ) of the PET responders , @ ( @ % , @-@ ) of those in group A , and six ( @ % , @-@ ) of those in group B. Incidences of grade @-@ adverse events were similar in all three groups .", "sentence_id": 18}
+{"abstract_id": "25456368", "label": "results", "text": "The most common grade @-@ adverse events were neutropenia ( four in PET responders , five in group A , and three in group B ) , febrile neutropenia ( one , three , and one , respectively ) , and myalgia ( four , none , and one , respectively ) .", "sentence_id": 19}
+{"abstract_id": "25456368", "label": "results", "text": "Overall , @ serious adverse events were reported in @ patients ( PET responders : nine events in four -LSB- @ % -RSB- of @ patients ; group A : @ events in ten -LSB- @ % -RSB- of @ patients ; group B : one event in one -LSB- @ % -RSB- of @ patients ) .", "sentence_id": 20}
+{"abstract_id": "25456368", "label": "results", "text": "No deaths occurred during the study .", "sentence_id": 21}
+{"abstract_id": "25456368", "label": "conclusions", "text": "In patients with HER@-positive breast cancer , early PET assessment can help to identify non-responders to neoadjuvant docetaxel plus trastuzumab therapy .", "sentence_id": 22}
+{"abstract_id": "25456368", "label": "conclusions", "text": "In these patients , the addition of bevacizumab can increase the proportion of patients achieving a pathological complete response .", "sentence_id": 23}
+{"abstract_id": "25456368", "label": "conclusions", "text": "This potential new role for PET and the activity of bevacizumab in this setting need to be confirmed in larger phase @ trials .", "sentence_id": 24}
+{"abstract_id": "25367165", "label": "objective", "text": "To describe secondary analyses from a @-week , randomized , open-label trial where adult schizophrenia outpatients receiving risperidone , olanzapine , or aripiprazole were switched to iloperidone .", "sentence_id": 0}
+{"abstract_id": "25367165", "label": "methods", "text": "Patients were randomized into two groups : one where the antecedent antipsychotic dose was titrated downwards to zero over @ weeks ( n = @ ) , and the other group where the antecedent antipsychotic was abruptly stopped ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25367165", "label": "methods", "text": "Adaptations of the Clinical Global Impression scale were used to evaluate clinical changes .", "sentence_id": 2}
+{"abstract_id": "25367165", "label": "methods", "text": "Other assessments included the reporting of adverse events ( AEs ) , study discontinuation , body weight , and metabolic variables .", "sentence_id": 3}
+{"abstract_id": "25367165", "label": "results", "text": "Improvement was steady throughout the study for both gradual - and immediate-switch groups starting at Week @ and continuing through Week @ .", "sentence_id": 4}
+{"abstract_id": "25367165", "label": "results", "text": "Discontinuations due to AEs in the first @ weeks of treatment were higher for the immediate-switch group compared with the gradual-switch group ( @ % vs. @ % , NNT @ , @ % CI @-@ ) .", "sentence_id": 5}
+{"abstract_id": "25367165", "label": "results", "text": "Fewer patients in the gradual-switch group experienced dizziness as an AE , whereas a higher percentage of patients in the immediate-switch group exhibited earlier onset of a therapeutic response within the first @ weeks ; both groups were comparable thereafter with low rates of dizziness and similar efficacy outcomes .", "sentence_id": 6}
+{"abstract_id": "25367165", "label": "conclusions", "text": "Switching to iloperidone can be accomplished either with a gradual crossover or immediate discontinuation of the prior antipsychotic ; however , the immediate-switch method is associated with greater proportion of initial dizziness .", "sentence_id": 7}
+{"abstract_id": "25367165", "label": "conclusions", "text": "The observed outcomes are consistent with what has been previously reported regarding iloperidone 's favorable akathisia/EPS profile and modest impact on somnolence/sedation , body weight , and metabolic variables .", "sentence_id": 8}
+{"abstract_id": "25609368", "label": "background", "text": "When performing clinical trials involving acupuncture , it can be difficult to choose a placebo control .", "sentence_id": 0}
+{"abstract_id": "25609368", "label": "objective", "text": "To validate the Park sham needle for use as a double-blind control intervention .", "sentence_id": 1}
+{"abstract_id": "25609368", "label": "methods", "text": "Two different methods were employed .", "sentence_id": 2}
+{"abstract_id": "25609368", "label": "methods", "text": "First , a researcher blinded to needle type administered the Park sham or a real needle , chosen at random , on the arms of @ healthy volunteers .", "sentence_id": 3}
+{"abstract_id": "25609368", "label": "methods", "text": "The researcher and the volunteers independently recorded which needle type they thought had been applied at each acupuncture point .", "sentence_id": 4}
+{"abstract_id": "25609368", "label": "methods", "text": "Second , @ patients with shoulder impingement syndrome were randomly assigned to receive acupuncture applied with the real needle or the Park sham needle , once a week for @ weeks alongside a course of physiotherapy .", "sentence_id": 5}
+{"abstract_id": "25609368", "label": "methods", "text": "At the end of the @ sessions the patients recorded which needle type they thought was being used .", "sentence_id": 6}
+{"abstract_id": "25609368", "label": "methods", "text": "The results were analyzed with a Fisher 's exact test .", "sentence_id": 7}
+{"abstract_id": "25609368", "label": "methods", "text": "This study was carried out in the Outpatient Department of Physiotherapy in Charing Cross Hospital , London , UK , on healthy volunteers and patients with shoulder impingement pain .", "sentence_id": 8}
+{"abstract_id": "25609368", "label": "methods", "text": "The age range was @ to @ and @ to @ years respectively .", "sentence_id": 9}
+{"abstract_id": "25609368", "label": "results", "text": "Of the healthy volunteers , there was no difference ( P = @ ) between the number of needles that were correctly ( n = @ ) or incorrectly identified ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "25609368", "label": "results", "text": "All patients thought that they had received the real needles .", "sentence_id": 11}
+{"abstract_id": "25609368", "label": "results", "text": "The researcher correctly identified all needles that were applied .", "sentence_id": 12}
+{"abstract_id": "25609368", "label": "conclusions", "text": "The researcher delivering the acupuncture recognized the needle type .", "sentence_id": 13}
+{"abstract_id": "25609368", "label": "conclusions", "text": "However , both healthy and patient volunteers were blind to the needle type .", "sentence_id": 14}
+{"abstract_id": "25609368", "label": "conclusions", "text": "This demonstrates that the Park sham needle is an effective single-blind control .", "sentence_id": 15}
+{"abstract_id": "25609368", "label": "conclusions", "text": "It should be noted that the number of patients recruited was small and the study was underpowered to detect an effect of treatment .", "sentence_id": 16}
+{"abstract_id": "25738670", "label": "background", "text": "The proteasome inhibitor bortezomib was initially approved for the treatment of relapsed mantle-cell lymphoma .", "sentence_id": 0}
+{"abstract_id": "25738670", "label": "background", "text": "We investigated whether substituting bortezomib for vincristine in frontline therapy with R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine , and prednisone ) could improve outcomes in patients with newly diagnosed mantle-cell lymphoma .", "sentence_id": 1}
+{"abstract_id": "25738670", "label": "methods", "text": "In this phase @ trial , we randomly assigned @ adults with newly diagnosed mantle-cell lymphoma who were ineligible or not considered for stem-cell transplantation to receive six to eight @-day cycles of R-CHOP intravenously on day @ ( with prednisone administered orally on days @ to @ ) or VR-CAP ( R-CHOP regimen , but replacing vincristine with bortezomib at a dose of @ mg per square meter of body-surface area on days @ , @ , @ , and @ ) .", "sentence_id": 2}
+{"abstract_id": "25738670", "label": "methods", "text": "The primary end point was progression-free survival .", "sentence_id": 3}
+{"abstract_id": "25738670", "label": "results", "text": "After a median follow-up of @ months , median progression-free survival ( according to independent radiologic review ) was @ months in the R-CHOP group versus @ months in the VR-CAP group ( hazard ratio favoring the VR-CAP group , @ ; P < @ ) , a relative improvement of @ % .", "sentence_id": 4}
+{"abstract_id": "25738670", "label": "results", "text": "On the basis of investigator assessment , the median durations of progression-free survival were @ months and @ months , respectively ( hazard ratio , @ ; P < @ ) , a relative improvement of @ % .", "sentence_id": 5}
+{"abstract_id": "25738670", "label": "results", "text": "Secondary end points were consistently improved in the VR-CAP group , including the complete response rate ( @ % vs. @ % ) , the median duration of complete response ( @ months vs. @ months ) , the median treatment-free interval ( @ months vs. @ months ) , and the @-year overall survival rate ( @ % vs. @ % ) .", "sentence_id": 6}
+{"abstract_id": "25738670", "label": "results", "text": "Rates of neutropenia and thrombocytopenia were higher in the VR-CAP group .", "sentence_id": 7}
+{"abstract_id": "25738670", "label": "conclusions", "text": "VR-CAP was more effective than R-CHOP in patients with newly diagnosed mantle-cell lymphoma but at the cost of increased hematologic toxicity .", "sentence_id": 8}
+{"abstract_id": "25738670", "label": "conclusions", "text": "( Funded by Janssen Research and Development and Millennium Pharmaceuticals ; LYM-@ ClinicalTrials.gov number , NCT@ . )", "sentence_id": 9}
+{"abstract_id": "25693055", "label": "objective", "text": "To investigate a new therapeutic strategy , with rapid corticosteroid dose tapering and limited cyclophosphamide ( CYC ) exposure , for older patients with systemic necrotizing vasculitides ( SNVs ; polyarteritis nodosa -LSB- PAN -RSB- , granulomatosis with polyangiitis -LSB- Wegnener 's -RSB- -LSB- GPA -RSB- , microscopic polyangiitis -LSB- MPA -RSB- , or eosinophilic GPA -LSB- Churg-Strauss -RSB- -LSB- EGPA -RSB- ) .", "sentence_id": 0}
+{"abstract_id": "25693055", "label": "methods", "text": "A multicenter , open-label , randomized controlled trial comprising patients @ years old and newly diagnosed as having SNV was conducted .", "sentence_id": 1}
+{"abstract_id": "25693055", "label": "methods", "text": "The experimental treatment consisted of corticosteroids for @ months and a maximum of six @-mg fixed-dose intravenous ( IV ) CYC pulses , every @-@ weeks , then maintenance azathioprine or methotrexate .", "sentence_id": 2}
+{"abstract_id": "25693055", "label": "methods", "text": "The control treatment included @ months of corticosteroids for all patients , combined with @ mg/m ( @ ) IV CYC pulses , every @-@ weeks until remission , then maintenance for all patients with GPA or MPA and for those with EGPA or PAN with a Five-Factors Score ( FFS ) of @ .", "sentence_id": 3}
+{"abstract_id": "25693055", "label": "methods", "text": "Randomization used a @:@ ratio computer-generated list and was performed centrally with sealed opaque envelopes .", "sentence_id": 4}
+{"abstract_id": "25693055", "label": "methods", "text": "The primary outcome measure was @ serious adverse event ( SAE ) occurring within @ years of followup .", "sentence_id": 5}
+{"abstract_id": "25693055", "label": "methods", "text": "Secondary outcome measures included remission and relapse rates .", "sentence_id": 6}
+{"abstract_id": "25693055", "label": "results", "text": "Among the @ patients randomized , @ were excluded ( early consent withdrawal or protocol violation ) .", "sentence_id": 7}
+{"abstract_id": "25693055", "label": "results", "text": "Mean SD age at diagnosis was @ @ years .", "sentence_id": 8}
+{"abstract_id": "25693055", "label": "results", "text": "Analysis at @ years included @ patients ( @ GPA , @ MPA , @ EGPA , and @ PAN ) in the experimental arm and @ patients ( @ GPA , @ MPA , @ EGPA , and @ PAN ) in the conventional arm .", "sentence_id": 9}
+{"abstract_id": "25693055", "label": "results", "text": "In total , @ ( @ % ) versus @ ( @ % ) had @ SAE ( P = @ ) , most frequently infections ; @ ( @ % ) versus @ ( @ % ) failed to achieve remission ( P = @ ) ; @ ( @ % ) versus @ ( @ % ) died ( P = @ ) ; and @ ( @ % ) of @ versus @ ( @ % ) of @ survivors in remission experienced a relapse ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25693055", "label": "conclusions", "text": "For older SNV patients , an induction regimen limiting corticosteroid exposure and with fixed low-dose IV CYC pulses reduces SAEs in comparison to conventional therapy , and does not affect the remission rate .", "sentence_id": 11}
+{"abstract_id": "25693055", "label": "conclusions", "text": "Three-year relapse rates remain high for both arms .", "sentence_id": 12}
+{"abstract_id": "24256028", "label": "objective", "text": "Acupuncture is increasingly used in patients with allergic asthma , but there is a lack of evidence on the cost-benefit relationship of this treatment .", "sentence_id": 0}
+{"abstract_id": "24256028", "label": "objective", "text": "The aim of this study was to assess economic aspects of additional acupuncture treatment in patients with allergic bronchial asthma compared to patients receiving routine care alone .", "sentence_id": 1}
+{"abstract_id": "24256028", "label": "objective", "text": "DESIGN , SUBJECTS , INTERVENTION , OUTCOME MEASURES : In a randomized controlled trial , patients with allergic bronchial asthma were either allocated to a group receiving acupuncture immediately or a waiting-list control group .", "sentence_id": 2}
+{"abstract_id": "24256028", "label": "objective", "text": "Both groups were free to use routine care treatment .", "sentence_id": 3}
+{"abstract_id": "24256028", "label": "objective", "text": "The resource consumption , costs , and health-related quality of life were evaluated at baseline , and after @ and @ months by using statutory health insurance information and standardized questionnaires .", "sentence_id": 4}
+{"abstract_id": "24256028", "label": "objective", "text": "Main economic outcome parameters were direct and indirect cost differences during the study period and the incremental cost-effectiveness ratio ( ICER ) of acupuncture treatment .", "sentence_id": 5}
+{"abstract_id": "24256028", "label": "results", "text": "Three hundred and six ( @ ) patients ( @ acupuncture ; @ controls ) were included ( mean age @ years , female @ % ) and were comparable at baseline .", "sentence_id": 6}
+{"abstract_id": "24256028", "label": "results", "text": "Acupuncture treatment was associated with significantly higher costs compared to control patients ( overall costs : @ -LSB- @ % confidence interval ( CI ) @-@ @ -RSB- versus @ -LSB- @ % CI @-@ @ -RSB- ; p = @ ; asthma-related costs : @ -LSB- @ % CI @-@ @ -RSB- versus @ -LSB- @ % CI @-@ @ -RSB- ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24256028", "label": "results", "text": "These additional costs seem essentially driven by acupuncture costs themselves ( @ -LSB- @ % CI @-@ @ -RSB- ) .", "sentence_id": 8}
+{"abstract_id": "24256028", "label": "results", "text": "However , acupuncture was associated with superior effectiveness in terms of quality-adjusted life years ( QALYs ) .", "sentence_id": 9}
+{"abstract_id": "24256028", "label": "results", "text": "Resulting ICER lay between @,@ ( overall ) and @,@ ( diagnosis-specific ) per additional QALY .", "sentence_id": 10}
+{"abstract_id": "24256028", "label": "results", "text": "When using German acupuncture prices of year @ , the ICER would improve to @ ( overall ) versus @,@ ( diagnosis-specific ) per QALY gained .", "sentence_id": 11}
+{"abstract_id": "24256028", "label": "conclusions", "text": "Treating patients who have allergic bronchial asthma with acupuncture in addition to routine care resulted in additional costs and better effects in terms of patients ' quality of life .", "sentence_id": 12}
+{"abstract_id": "24256028", "label": "conclusions", "text": "Acupuncture therefore seems to be a useful and cost-effective add-on treatment .", "sentence_id": 13}
+{"abstract_id": "24583294", "label": "objective", "text": "The aim of this study was to assess whether deferred stenting might reduce no-reflow and salvage myocardium in primary percutaneous coronary intervention ( PCI ) for ST-segment elevation myocardial infarction ( STEMI ) .", "sentence_id": 0}
+{"abstract_id": "24583294", "label": "background", "text": "No-reflow is associated with adverse outcomes in STEMI .", "sentence_id": 1}
+{"abstract_id": "24583294", "label": "methods", "text": "This was a prospective , single-center , randomized , controlled , proof-of-concept trial in reperfused STEMI patients with @ risk factors for no-reflow .", "sentence_id": 2}
+{"abstract_id": "24583294", "label": "methods", "text": "Randomization was to deferred stenting with an intention-to-stent @ to @ h later or conventional treatment with immediate stenting .", "sentence_id": 3}
+{"abstract_id": "24583294", "label": "methods", "text": "The primary outcome was the incidence of no - / slow-reflow ( Thrombolysis In Myocardial Infarction @ ) .", "sentence_id": 4}
+{"abstract_id": "24583294", "label": "methods", "text": "Cardiac magnetic resonance imaging was performed @ days and @ months after myocardial infarction .", "sentence_id": 5}
+{"abstract_id": "24583294", "label": "methods", "text": "Myocardial salvage was the final infarct size indexed to the initial area at risk .", "sentence_id": 6}
+{"abstract_id": "24583294", "label": "results", "text": "Of @ STEMI patients ( March @ , @ to November @ , @ ) , @ patients ( mean age , @ years ; @ % male ) were randomized ( @ to the deferred stenting group , @ to the immediate stenting ) .", "sentence_id": 7}
+{"abstract_id": "24583294", "label": "results", "text": "The median ( interquartile range -LSB- IQR -RSB- ) time to the second procedure in the deferred stenting group was @ h ( IQR : @ to @ h ) .", "sentence_id": 8}
+{"abstract_id": "24583294", "label": "results", "text": "Fewer patients in the deferred stenting group had no - / slow-reflow ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ; p = @ ) , no reflow ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ; p = @ ) and intraprocedural thrombotic events ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ; p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24583294", "label": "results", "text": "Thrombolysis In Myocardial Infarction coronary flow grades at the end of PCI were higher in the deferred stenting group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24583294", "label": "results", "text": "Recurrent STEMI occurred in @ patients in the deferred stenting group before the second procedure .", "sentence_id": 11}
+{"abstract_id": "24583294", "label": "results", "text": "Myocardial salvage index at @ months was greater in the deferred stenting group ( @ -LSB- IQR : @ % to @ % -RSB- vs. @ -LSB- IQR : @ % to @ % -RSB- ; p = @ -RSB- .", "sentence_id": 12}
+{"abstract_id": "24583294", "label": "conclusions", "text": "In high-risk STEMI patients , deferred stenting in primary PCI reduced no-reflow and increased myocardial salvage .", "sentence_id": 13}
+{"abstract_id": "24583294", "label": "conclusions", "text": "( Deferred Stent Trial in STEMI ; NCT@ ) .", "sentence_id": 14}
+{"abstract_id": "24444862", "label": "objective", "text": "Cognitive deficits that characterize schizophrenia are present in the prodrome , worsen with illness onset , and predict functional outcome .", "sentence_id": 0}
+{"abstract_id": "24444862", "label": "objective", "text": "Cognitive dysfunction is thus a critical target for early intervention in young individuals with recent onset schizophrenia .", "sentence_id": 1}
+{"abstract_id": "24444862", "label": "methods", "text": "This @-site double-blind randomized controlled trial investigated cognitive training of auditory processing/verbal learning in @ subjects with recent onset schizophrenia ( mean age of @ years ) .", "sentence_id": 2}
+{"abstract_id": "24444862", "label": "methods", "text": "Subjects were given laptop computers to take home and were asked to perform @ hours of training or @ hours of commercial computer games over @ weeks .", "sentence_id": 3}
+{"abstract_id": "24444862", "label": "methods", "text": "We examined cognitive measures recommended by the Measurement and Treatment Research to Improve Cognition in Schizophrenia initiative ( MATRICS ) , symptoms , and functioning .", "sentence_id": 4}
+{"abstract_id": "24444862", "label": "methods", "text": "We also assessed baseline reward anticipation to index motivational system functioning and measured changes in auditory processing speed after @ hours of training to assess target engagement .", "sentence_id": 5}
+{"abstract_id": "24444862", "label": "results", "text": "Auditory training subjects demonstrated significant improvements in global cognition , verbal memory , and problem solving compared with those of computer games control subjects .", "sentence_id": 6}
+{"abstract_id": "24444862", "label": "results", "text": "Both groups showed a slight but significant decrease in symptoms and no change in functional outcome measures .", "sentence_id": 7}
+{"abstract_id": "24444862", "label": "results", "text": "Training-induced cognitive gains at posttraining showed significant associations with reward anticipation at baseline and with improvement in auditory processing speed at @ hours .", "sentence_id": 8}
+{"abstract_id": "24444862", "label": "conclusions", "text": "Neuroscience-informed cognitive training via laptop computer represents a promising treatment approach for cognitive dysfunction in early schizophrenia .", "sentence_id": 9}
+{"abstract_id": "24444862", "label": "conclusions", "text": "An individual 's baseline motivational system functioning ( reward anticipation ) , and ability to engage in auditory processing speed improvement , may represent important predictors of treatment outcome .", "sentence_id": 10}
+{"abstract_id": "24444862", "label": "conclusions", "text": "Future studies must investigate whether cognitive training improves functioning and how best to integrate it into critical psychosocial interventions .", "sentence_id": 11}
+{"abstract_id": "25549639", "label": "objective", "text": "To explore the possible mechanisms for improving lower extremity motor function in patients with early stroke through combining magnetic resonance diffusion tensor imaging ( DTI ) technology and functional electrical stimulation ( FES ) based on human walking patterns .", "sentence_id": 0}
+{"abstract_id": "25549639", "label": "methods", "text": "From August @ to September @ , a total of @ eligible patients were stratified according to age , gender , disease course , Brunnstrom staging and types of stroke .", "sentence_id": 1}
+{"abstract_id": "25549639", "label": "methods", "text": "And the Minimize software was used to divided them randomly into four-channel FES group ( n = @ ) , dual-channel FES group ( n = @ ) and comfort stimulation group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25549639", "label": "methods", "text": "For all three groups , general medication and standard rehabilitation were provided .", "sentence_id": 3}
+{"abstract_id": "25549639", "label": "methods", "text": "Based on normal walking pattern design of FES treatment , four-channel FES groups received the stimulations of quadriceps , hamstring , anterior tibialis and medial gastrocnemius .", "sentence_id": 4}
+{"abstract_id": "25549639", "label": "methods", "text": "For the dual-channel FES group , the stimulations of tibialis anterior , peroneus longus and peroneus brevis muscles were applied .", "sentence_id": 5}
+{"abstract_id": "25549639", "label": "methods", "text": "In comfort electrical stimulation group , the electrode positions were identical to the stimulation group , but there was no current output during stimulation .", "sentence_id": 6}
+{"abstract_id": "25549639", "label": "methods", "text": "Before and after @-week treatment , three groups received weekly rehabilitation evaluations of Fugl-Meyer assessment ( FMA ) , posture assessment of stroke scale ( PASS ) , Brunel balance assessment ( BBA ) , Berg balance scale ( BBS ) and modified Barthel index ( MBI ) .", "sentence_id": 7}
+{"abstract_id": "25549639", "label": "methods", "text": "Before and after treatment , DTI examination was performed for some patients .", "sentence_id": 8}
+{"abstract_id": "25549639", "label": "results", "text": "Among three groups , general patient profiles and pre-treatment evaluations showed no significant difference .", "sentence_id": 9}
+{"abstract_id": "25549639", "label": "results", "text": "For intra-group comparisons versus pre-treatment , at week @ , @ and @ , the scores of PASS , BBA , BBS , FMA and MBI had statistically significant differences ( P < @ ) ; At week @ post-treatment , when four-channel and double-channel FES groups were compared versus pre-treatment , the scores of ipsilateral FA had statistically significant differences ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25549639", "label": "results", "text": "At week @ post-treatment , MBI had statistically significant difference among @ groups ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25549639", "label": "results", "text": "As compared with placebo , four-channel group had statistically significant difference -LSB- ( @ @ ) vs ( @ @ ) , P < @ -RSB- ; At week @ post-treatment , the scores of PASS and MBI were ( @ @ , @ @ ) in four-channel FES group versus ( @ @ , @ @ ) in dual-channel FES group .", "sentence_id": 12}
+{"abstract_id": "25549639", "label": "results", "text": "And the scores of PASS , BBA , BBS , FMA and MBI were ( @ @ , @ @ , @ @ , @ @ , @ @ ) in four-channel FES group versus ( @ @ , @ @ , @ @ , @ @ , @ @ ) in comfort electrical stimulation group .", "sentence_id": 13}
+{"abstract_id": "25549639", "label": "results", "text": "When dual-channel FES and comfort stimulation groups were compared , MBI had significant statistical difference -LSB- ( @ @ ) vs ( @ @ ) , P < @ -RSB- .", "sentence_id": 14}
+{"abstract_id": "25549639", "label": "results", "text": "At week @ post-treatment , four-channel and dual-channel FES groups were compared , there was also statistical significance in FMA -LSB- ( @ @ ) vs ( @ @ ) , P = @ -RSB- .", "sentence_id": 15}
+{"abstract_id": "25549639", "label": "results", "text": "The scores of PASS , BBS , FMA and MBI were ( @ @ , @ @ , @ @ , @ @ ) in four-channel FES group versus ( @ @ , @ @ , @ @ , @ @ ) in comfort stimulation group respectively .", "sentence_id": 16}
+{"abstract_id": "25549639", "label": "results", "text": "When dual-channel FES and comfort stimulation groups were compared , the scores of MBI were ( @ @ ) and ( @ @ ) respectively .", "sentence_id": 17}
+{"abstract_id": "25549639", "label": "results", "text": "And the difference was statistically significant ( P < @ ) .", "sentence_id": 18}
+{"abstract_id": "25549639", "label": "results", "text": "At week @ post-treatment , the scores of FA significantly increased -LSB- four-channel FES group ( @ @ ) vs comfort stimulation group ( @ @ ) ( P = @ ) -RSB- .", "sentence_id": 19}
+{"abstract_id": "25549639", "label": "results", "text": "When dual-channel FES group ( @ @ ) and comfort stimulation group ( @ @ ) ( P = @ ) were compared , the differences were statistically significant .", "sentence_id": 20}
+{"abstract_id": "25549639", "label": "results", "text": "DTI showed that four-channel FES group increased significantly , but contralateral fiber bundle was not obvious .", "sentence_id": 21}
+{"abstract_id": "25549639", "label": "results", "text": "And the improvements of dual-channel FES and comfort stimulation groups were insignificant .", "sentence_id": 22}
+{"abstract_id": "25549639", "label": "conclusions", "text": "Compared with traditional dual-channel FES , functional electrical stimulation based on human walking patterns is more efficacious .", "sentence_id": 23}
+{"abstract_id": "25549639", "label": "conclusions", "text": "And it helps to restore brain structure and function and promote motor function recovery in patients with early stroke .", "sentence_id": 24}
+{"abstract_id": "24439636", "label": "objective", "text": "This study sought to determine the effects of lavender aromatherapy on pain following needle insertion into a fistula in patients undergoing hemodialysis .", "sentence_id": 0}
+{"abstract_id": "24439636", "label": "methods", "text": "This is a randomized controlled clinical trial in which @ patients undergoing hemodialysis with arteriovenous fistulas were randomly divided into two groups .", "sentence_id": 1}
+{"abstract_id": "24439636", "label": "methods", "text": "The experimental-group patients inhaled lavender essence with a concentration of @ % for @min during @ hemodialysis sessions , while the control-group patients received aromatherapy free of lavender essence .", "sentence_id": 2}
+{"abstract_id": "24439636", "label": "results", "text": "The mean VAS pain intensity score in the experimental and control groups before the intervention was @ and @ , respectively ( p = @ ) .", "sentence_id": 3}
+{"abstract_id": "24439636", "label": "results", "text": "The mean VAS pain intensity score in the experimental and control groups after three aromatherapy sessions was @ and @ , respectively ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24439636", "label": "conclusions", "text": "Lavender aromatherapy may be an effective technique to reduce pain following needle insertion into a fistula in hemodialysis patients .", "sentence_id": 5}
+{"abstract_id": "25262224", "label": "background", "text": "Hyperparathyroidism ( HPT ) in multiple endocrine neoplasia ( MEN ) type @ is associated with multiglandular parathyroid disease .", "sentence_id": 0}
+{"abstract_id": "25262224", "label": "background", "text": "Previous retrospective studies comparing subtotal parathyroidectomy ( SP ) and total parathyroidectomy with autotransplantation ( TP/AT ) have not established clearly better outcomes with either procedure .", "sentence_id": 1}
+{"abstract_id": "25262224", "label": "methods", "text": "Patients were assigned randomly to either SP or TP/AT and data were collected prospectively .", "sentence_id": 2}
+{"abstract_id": "25262224", "label": "methods", "text": "The rates of persistent HPT , recurrent HPT , and postoperative hypoparathyroidism were compared .", "sentence_id": 3}
+{"abstract_id": "25262224", "label": "results", "text": "The study cohort included @ patients randomized to receive either SP or TP/AT ( mean follow-up , @ @ years ) .", "sentence_id": 4}
+{"abstract_id": "25262224", "label": "results", "text": "The overall rate of recurrent HPT was @ % ( @/@ ) .", "sentence_id": 5}
+{"abstract_id": "25262224", "label": "results", "text": "Recurrent HPT occurred in @ of @ patients ( @ % ) treated with SP and @ of @ patients ( @ % ) treated with TP/AT ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25262224", "label": "results", "text": "Permanent hypoparathyroidism occurred in @ of @ patients ( @ % ) overall .", "sentence_id": 7}
+{"abstract_id": "25262224", "label": "results", "text": "The rate of permanent hypoparathyroidism was @ % in the SP group ( @/@ ) and @ % in the TP/AT group ( @/@ ) .", "sentence_id": 8}
+{"abstract_id": "25262224", "label": "results", "text": "A second operation was performed in @ of @ patients initially treated with SP ( @ % ) , compared with @ of @ patients undergoing TP/AT ( @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25262224", "label": "conclusions", "text": "This randomized trial of SP and TP/AT in patients with MEN @ failed to show any difference in outcomes when comparing results of SP versus TP/AT .", "sentence_id": 10}
+{"abstract_id": "25262224", "label": "conclusions", "text": "Both procedures are associated with acceptable results , but SP may have advantages in that is involves only @ surgical incision and avoids an obligate period of transient postoperative hypoparathyroidism .", "sentence_id": 11}
+{"abstract_id": "25260232", "label": "background", "text": "Adhesions develop in over @ % of patients after intra-abdominal surgery .", "sentence_id": 0}
+{"abstract_id": "25260232", "label": "background", "text": "Adhesion barriers are rarely used despite the high morbidity caused by intra-abdominal adhesions .", "sentence_id": 1}
+{"abstract_id": "25260232", "label": "background", "text": "Only one of the currently available adhesion barriers has demonstrated consistent evidence for reducing adhesions in visceral surgery .", "sentence_id": 2}
+{"abstract_id": "25260232", "label": "background", "text": "This agent has limitations through poor handling characteristics because it is sticky on both sides .", "sentence_id": 3}
+{"abstract_id": "25260232", "label": "background", "text": "C-Qur Film is a novel thin film adhesion barrier and it is sticky on only one side , resulting in better handling characteristics .", "sentence_id": 4}
+{"abstract_id": "25260232", "label": "background", "text": "The objective of this study is to assess efficacy and safety of C-Qur Film to decrease the incidence of adhesions after colorectal surgery .", "sentence_id": 5}
+{"abstract_id": "25260232", "label": "methods", "text": "This is a prospective , investigator initiated , randomized , double-blinded , multicenter trial .", "sentence_id": 6}
+{"abstract_id": "25260232", "label": "methods", "text": "Eligible patients undergoing colorectal resection requiring temporary loop ileostomy or loop/split colostomy by laparotomy or hand assisted laparoscopy will be included in the trial .", "sentence_id": 7}
+{"abstract_id": "25260232", "label": "methods", "text": "Before closure , patients are randomized @:@ to either the treatment arm ( C-Qur Film ) or control arm ( no adhesion barrier ) .", "sentence_id": 8}
+{"abstract_id": "25260232", "label": "methods", "text": "Patients will return @ to @ weeks post-colorectal resection for take down of their ostomy .", "sentence_id": 9}
+{"abstract_id": "25260232", "label": "methods", "text": "During ostomy takedown , adhesions will be evaluated for incidence , extent , and severity .", "sentence_id": 10}
+{"abstract_id": "25260232", "label": "methods", "text": "The primary outcome evaluation will be assessment of adhesions to the incision site .", "sentence_id": 11}
+{"abstract_id": "25260232", "label": "methods", "text": "It is hypothesized that the use of C-Qur Film underneath the primary incision reduces the incidence of adhesion at the incision by @ % .", "sentence_id": 12}
+{"abstract_id": "25260232", "label": "methods", "text": "To demonstrate @ % reduction in the incidence of adhesions , a sample size of @ patients ( @ + @ per group ( @ % drop out ) ) is required ( two-sided test , = @ , @ % power ) .", "sentence_id": 13}
+{"abstract_id": "25260232", "label": "conclusions", "text": "Results of this study add to the evidence on the use of anti-adhesive barriers in open and laparoscopic ` hand-assisted ' colorectal surgery .", "sentence_id": 14}
+{"abstract_id": "25260232", "label": "conclusions", "text": "We chose incidence of adhesions to the incision site as primary outcome measure since clinical outcomes such as small bowel obstruction , secondary infertility and adhesiolysis related complications are considered multifactorial and difficult to interpret .", "sentence_id": 15}
+{"abstract_id": "25260232", "label": "conclusions", "text": "Incidence of adhesions at repeat surgery is believed to be the most valuable surrogate endpoint for clinically relevant adhesion prevention , since small bowel obstruction and adhesiolysis at repeat surgery are not likely to occur when complete adhesion reduction in a patient is accomplished .", "sentence_id": 16}
+{"abstract_id": "24914427", "label": "objective", "text": "To assess the impact of empowerment ( health coaching , HC ) on toothbrushing self-efficacy ( TBSE ) and toothbrushing frequency ( TB ) and their effects on diabetes management ( HbA@c , physical activity ) and quality of life in comparison to health education ( HE ) among patients with diabetes type @ ( DM@ ) .", "sentence_id": 0}
+{"abstract_id": "24914427", "label": "methods", "text": "The data ( HbA@c -LSB- glycated haemoglobin -RSB- , TB , physical activity , TBSE , quality of life ) were collected at baseline and at post-intervention at outpatient clinics of two hospitals in Istanbul , Turkey .", "sentence_id": 1}
+{"abstract_id": "24914427", "label": "methods", "text": "Participants were allocated randomly to HC ( n = @ ) and HE ( n = @ ) groups .", "sentence_id": 2}
+{"abstract_id": "24914427", "label": "results", "text": "At baseline , there were no statistical differences between HC and HE groups in terms of all measures ( P > @ ) .", "sentence_id": 3}
+{"abstract_id": "24914427", "label": "results", "text": "At post-intervention , there was improvement in oral health - and diabetes-related variables in the HC group , whereas only TBSE and TB slightly improved in the HE group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24914427", "label": "results", "text": "At post-intervention among patients brushing their teeth at least once a day , HC group patients were more likely to be physically active and to have high self-efficacy than those in HE group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24914427", "label": "results", "text": "TBSE was correlated with favourable HbA@c levels ( < @ % ) in the HC group and quality of life ( P < @ ) in both groups .", "sentence_id": 6}
+{"abstract_id": "24914427", "label": "conclusions", "text": "The findings show that HC-based empowerment towards improving self-efficacy is more effective at improving toothbrushing behaviour than is HE and that interaction contributes significantly to diabetes management in terms of reduced HbA@c , increased physical activity and quality of life .", "sentence_id": 7}
+{"abstract_id": "24914427", "label": "conclusions", "text": "TBSE can be a practical starting point for empowerment and toothbrushing can be used as an effective and practical behaviour to observe personal success in diabetes management .", "sentence_id": 8}
+{"abstract_id": "24595505", "label": "background", "text": "Previous research has shown limited efficacy of nicotine replacement therapy ( NRT ) among adolescents and generally low compliance rates .", "sentence_id": 0}
+{"abstract_id": "24595505", "label": "background", "text": "As higher compliance rates are associated with improved abstinence rates , the present study examined predictors of NRT compliance .", "sentence_id": 1}
+{"abstract_id": "24595505", "label": "objective", "text": "This study aims to test whether different NRT compliance trajectories can be distinguished among adolescents , to test whether these trajectories can be predicted by demographic , smoking-related , and personality factors , and to examine abstinence rates for each trajectory .", "sentence_id": 2}
+{"abstract_id": "24595505", "label": "methods", "text": "Data were used from a randomized controlled trial that tested the efficacy of nicotine patches versus placebo patches among @ Dutch adolescents .", "sentence_id": 3}
+{"abstract_id": "24595505", "label": "methods", "text": "During NRT treatment , adolescents filled out six online questionnaires in which they reported on the number of days they used the patches .", "sentence_id": 4}
+{"abstract_id": "24595505", "label": "methods", "text": "Predictors ( i.e. , demographic and smoking-related factors and personality characteristics ) and end-of-treatment abstinence were also administered through these self-reports .", "sentence_id": 5}
+{"abstract_id": "24595505", "label": "methods", "text": "Latent class growth analysis ( LCGA ) was used to analyze compliance data by classifying individuals into similar growth trajectories .", "sentence_id": 6}
+{"abstract_id": "24595505", "label": "results", "text": "Three compliance trajectories were found ( i.e. , `` compliers '' ( n = @ ) , `` moderate decreasers '' ( n = @ ) , and `` strong decreasers '' ( n = @ ) ) .", "sentence_id": 7}
+{"abstract_id": "24595505", "label": "results", "text": "The compliers can be characterized by higher levels of conscientiousness and agreeableness and lower levels of extraversion compared with the strong decreasers , and by higher levels of conscientiousness and education compared with the moderate decreasers .", "sentence_id": 8}
+{"abstract_id": "24595505", "label": "results", "text": "Among the compliers , a substantially higher percentage of adolescents achieved abstinence at end-of-treatment ( @ % ) compared with the moderate decreasers ( @ % ) and the strong decreasers ( @ % ) .", "sentence_id": 9}
+{"abstract_id": "24595505", "label": "conclusions", "text": "These findings could be the starting point for person-tailored interventions that aim to enhance NRT compliance rates among adolescents .", "sentence_id": 10}
+{"abstract_id": "24493237", "label": "objective", "text": "This study investigates the efficacy of the @-hour REACH Forgiveness intervention among culturally diverse undergraduates .", "sentence_id": 0}
+{"abstract_id": "24493237", "label": "methods", "text": "Female undergraduates ( N = @ ) and foreign extraction ( @ % ) and domestic ( @ % ) students in the United States were randomly assigned to immediate treatment or waitlist conditions .", "sentence_id": 1}
+{"abstract_id": "24493237", "label": "methods", "text": "Treatment efficacy and the effect of culture on treatment response were assessed using measures of emotional and decisional forgiveness across @ time periods .", "sentence_id": 2}
+{"abstract_id": "24493237", "label": "results", "text": "Students in the treatment condition reported greater improvement in emotional forgiveness , but not decisional forgiveness , relative to those in the waitlist condition .", "sentence_id": 3}
+{"abstract_id": "24493237", "label": "results", "text": "Gains were maintained at a @-week follow-up .", "sentence_id": 4}
+{"abstract_id": "24493237", "label": "results", "text": "Although culture did not moderate the effect of treatment , a main effect of culture on emotional forgiveness and marginally significant interaction effect of culture on decisional forgiveness were found .", "sentence_id": 5}
+{"abstract_id": "24493237", "label": "conclusions", "text": "The REACH Forgiveness intervention was efficacious for college students from different cultural backgrounds when conducted in the United States .", "sentence_id": 6}
+{"abstract_id": "24493237", "label": "conclusions", "text": "However , some evidence may warrant development of culturally adapted forgiveness interventions .", "sentence_id": 7}
+{"abstract_id": "25217122", "label": "background", "text": "This study was designed to evaluate the safety and efficacy of a novel , self-cross-linked hyaluronic acid ( HA ) hydrogel compared with carboxymethylcellulose ( CMC ) viscous foam in promoting healing when applied after ethmoidectomy .", "sentence_id": 0}
+{"abstract_id": "25217122", "label": "background", "text": "A prospective , randomized , controlled , blinded clinical trial was performed .", "sentence_id": 1}
+{"abstract_id": "25217122", "label": "background", "text": "The study was performed by four surgeons operating in two community hospitals .", "sentence_id": 2}
+{"abstract_id": "25217122", "label": "methods", "text": "Thirty patients with bilateral chronic rhinosinusitis underwent bilateral total ethmoidectomy .", "sentence_id": 3}
+{"abstract_id": "25217122", "label": "methods", "text": "Intraoperatively , each patient received @ mL of HA hydrogel in one ethmoid cavity and @ mL of CMC contralaterally .", "sentence_id": 4}
+{"abstract_id": "25217122", "label": "methods", "text": "The material applied within each ethmoid cavity was randomly assigned before surgery .", "sentence_id": 5}
+{"abstract_id": "25217122", "label": "methods", "text": "An independent surgeon , blinded to the material used to treat each ethmoid cavity , evaluated postoperative endoscopic video at @ and @ weeks for edema , crusting , and mucopurulence and at @ and @ weeks for remucosalization and scarring/synechiae .", "sentence_id": 6}
+{"abstract_id": "25217122", "label": "methods", "text": "Twenty-item Sino-Nasal Outcome Test SNOT-@ data were collected at each visit .", "sentence_id": 7}
+{"abstract_id": "25217122", "label": "methods", "text": "A small sample underwent endoscopic mucosal biopsy .", "sentence_id": 8}
+{"abstract_id": "25217122", "label": "results", "text": "Twenty-nine of @ patients completed the protocol .", "sentence_id": 9}
+{"abstract_id": "25217122", "label": "results", "text": "The difference in edema , crusting , and mucopurulence at @ and @ weeks was not statistically significant ; however , at @ and @ weeks , the HA hydrogel showed statistically significant reduction in both overall endoscopic grade ( p < @ ) , as well as synechiae formation ( p < @ ) , with a trend toward superiority in remucosalization ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25217122", "label": "results", "text": "Histological analysis of six subjects at @ weeks showed a nonsignificant trend toward a greater amount of regenerated cilia present with the HA hydrogel ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "25217122", "label": "results", "text": "SNOT-@ scores declined @ % from preoperative scores .", "sentence_id": 12}
+{"abstract_id": "25217122", "label": "conclusions", "text": "Self-cross-linked HA hydrogel provides superior wound healing to CMC after ethmoidectomy .", "sentence_id": 13}
+{"abstract_id": "25555183", "label": "objective", "text": "Although there is scientific evidence that stress adversely affects metabolic control , only a few studies have examined the role of stress management in improving glycemic control in patients with type @ diabetes mellitus ( DM ) .", "sentence_id": 0}
+{"abstract_id": "25555183", "label": "objective", "text": "In this study , we investigated the effect of a relaxation technique on levels of stress and glycemic control .", "sentence_id": 1}
+{"abstract_id": "25555183", "label": "methods", "text": "A total of @ patients with type @ DM were randomly assigned to undergo either an @-week stress management program , consisting of @ min of diaphragmatic breathing and @ min of progressive muscle relaxation twice per day ( n = @ , intervention group ) , or not ( n = @ , control group ) .", "sentence_id": 2}
+{"abstract_id": "25555183", "label": "methods", "text": "Perceived stress , health locus of control and HbA@c were primary outcomes and were measured before and after intervention .", "sentence_id": 3}
+{"abstract_id": "25555183", "label": "results", "text": "In the intervention group , perceived stress score ( PSS ) and HbA@c had decreased significantly ( P < @ ) by the end of the program .", "sentence_id": 4}
+{"abstract_id": "25555183", "label": "results", "text": "Specifically concerning the PSS , the higher the initial levels of perceived stress the greater the benefit of the intervention .", "sentence_id": 5}
+{"abstract_id": "25555183", "label": "results", "text": "No other significant changes were found .", "sentence_id": 6}
+{"abstract_id": "25555183", "label": "conclusions", "text": "Our results show a beneficial role of stress management for patients with type @ DM , as regards both stress levels and glycemic control .", "sentence_id": 7}
+{"abstract_id": "25555183", "label": "conclusions", "text": "It is recommended to consider this type of treatment as an adjunct to conventional therapy .", "sentence_id": 8}
+{"abstract_id": "25555183", "label": "conclusions", "text": "We deem that our study could encourage future studies in this area with larger samples , longer duration and more objective measurements .", "sentence_id": 9}
+{"abstract_id": "24427264", "label": "background", "text": "Community-based peer support has been shown to be effective in improving exclusive breastfeeding rates in a variety of settings .", "sentence_id": 0}
+{"abstract_id": "24427264", "label": "methods", "text": "We conducted a cost analysis of a community cluster randomised-controlled trial ( Promise-EBF ) , aimed at promoting exclusive infant feeding in three sites in South Africa .", "sentence_id": 1}
+{"abstract_id": "24427264", "label": "methods", "text": "The costs were considered from the perspective of health service providers .", "sentence_id": 2}
+{"abstract_id": "24427264", "label": "methods", "text": "Peer supporters in this trial visited women to support exclusive infant feeding , once antenatally and four times postpartum .", "sentence_id": 3}
+{"abstract_id": "24427264", "label": "results", "text": "The total economic cost of the Promise-EBF intervention was US$ @ @ , with average costs per woman and per visit of US$ @ and US$ @ , respectively .", "sentence_id": 4}
+{"abstract_id": "24427264", "label": "results", "text": "The average costs per woman and visit in an operational ` non research ' scenario were US$ @ and US$ @ per woman and visit , respectively .", "sentence_id": 5}
+{"abstract_id": "24427264", "label": "results", "text": "Investing in the promotion of exclusive infant feeding requires substantial financial commitment from policy makers .", "sentence_id": 6}
+{"abstract_id": "24427264", "label": "results", "text": "Extending the tasks of multi-skilled community health workers ( CHWs ) to include promoting exclusive infant feeding is a potential option for reducing these costs .", "sentence_id": 7}
+{"abstract_id": "24427264", "label": "results", "text": "In order to avoid efficiency losses , we recommend that the time requirements for delivering the promotion of exclusive infant feeding are considered when integrating it within the existing activities of CHWs .", "sentence_id": 8}
+{"abstract_id": "24427264", "label": "conclusions", "text": "This paper focuses on interventions for exclusive infant feeding , but its findings more generally illustrate the importance of documenting and quantifying factors that affect the feasibility and sustainability of community-based interventions , which are receiving increased focus in low income settings .", "sentence_id": 9}
+{"abstract_id": "25522928", "label": "objective", "text": "The purpose of this study was to identify the effects of water-based exercises on the physical functions and quality of life ( QOL ) in community-dwelling elderly people with history of falling .", "sentence_id": 0}
+{"abstract_id": "25522928", "label": "methods", "text": "Participants were randomly assigned to the water-based exercise group ( n = @ ) or land-based exercise groups ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25522928", "label": "methods", "text": "To identify the effects on physical functions , muscle strength , flexibility , and mobility were measured .", "sentence_id": 2}
+{"abstract_id": "25522928", "label": "methods", "text": "QOL and fear of falling were evaluated using the Short Form @-item questionnaire and the modified falls efficacy scale ( M-FES ) .", "sentence_id": 3}
+{"abstract_id": "25522928", "label": "methods", "text": "The measurements were performed before and after the @-week training period .", "sentence_id": 4}
+{"abstract_id": "25522928", "label": "results", "text": "Within-group analysis indicated that hip abduction and adduction strength improved significantly in both groups ( p = @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25522928", "label": "results", "text": "However , no statistically significant within-group differences were found in the back scratch test ( p = @ ) and chair sit-and-reach test ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25522928", "label": "results", "text": "QOL was significantly different in both groups ( health transition : p = @ , physical functioning : p < @ , role physical : p < @ , role emotional : p = @ , bodily pain : p < @ , vitality : p < @ , and mental health : p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25522928", "label": "results", "text": "There was a significant difference in the M-FES in both groups ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25522928", "label": "conclusions", "text": "These results indicate that water-based exercises are beneficial to improve the QOL , as well as physical activities , of community-dwelling elderly compared with land-based exercise .", "sentence_id": 9}
+{"abstract_id": "25522928", "label": "conclusions", "text": "Water-based exercises would be useful to improve physical and psychological health in the elderly people with history of falling .", "sentence_id": 10}
+{"abstract_id": "24947817", "label": "background", "text": "Urinary stone disease is common , with an estimated prevalence among the general population of @ % to @ % .", "sentence_id": 0}
+{"abstract_id": "24947817", "label": "background", "text": "Ureteric stones can cause severe pain and have a significant impact on quality of life , accounting for over @,@ hospital admissions in England annually .", "sentence_id": 1}
+{"abstract_id": "24947817", "label": "background", "text": "Uncomplicated cases of smaller stones in the lower ureter are traditionally treated expectantly .", "sentence_id": 2}
+{"abstract_id": "24947817", "label": "background", "text": "Those who fail standard care or develop complications undergo active treatment , such as extracorporeal shock wave lithotripsy or ureteroscopy with stone retrieval .", "sentence_id": 3}
+{"abstract_id": "24947817", "label": "background", "text": "Such interventions are expensive , require urological expertise and carry a risk of complications.Growing understanding of ureteric function and pathophysiology has led to the hypothesis that drugs causing relaxation of ureteric smooth muscle , such as the selective - blocker tamsulosin and the calcium-channel blocker nifedipine , can enhance the spontaneous passage of ureteric stones .", "sentence_id": 4}
+{"abstract_id": "24947817", "label": "background", "text": "The use of drugs in augmenting stone passage , reducing the morbidity and costs associated with ureteric stone disease , is promising .", "sentence_id": 5}
+{"abstract_id": "24947817", "label": "background", "text": "However , the majority of clinical trials conducted to date have been small , poor to moderate quality and lacking in comprehensive economic evaluation.This trial aims to determine the clinical and cost-effectiveness of tamsulosin and nifedipine in the management of symptomatic urinary stones .", "sentence_id": 6}
+{"abstract_id": "24947817", "label": "methods", "text": "The SUSPEND ( Spontaneous Urinary Stone Passage ENabled by Drugs ) trial is a multicentre , double-blind , randomized controlled trial evaluating two medical expulsive therapy strategies ( nifedipine or tamsulosin ) versus placebo.Patients aged @ to @ with a ureteric stone confirmed by non-contrast computed tomography of the kidney , ureter and bladder will be randomized to receive nifedipine , tamsulosin or placebo ( @ participants per arm ) for a maximum of @days .", "sentence_id": 7}
+{"abstract_id": "24947817", "label": "methods", "text": "The primary clinical outcome is spontaneous passage of ureteric stones at @weeks ( defined as no further intervention required to facilitate stone passage ) .", "sentence_id": 8}
+{"abstract_id": "24947817", "label": "methods", "text": "The primary economic outcome is a reduction in the incremental cost per quality-adjusted life years , determined at @weeks .", "sentence_id": 9}
+{"abstract_id": "24947817", "label": "methods", "text": "The analysis will be based on all participants as randomized ( intention to treat ) .", "sentence_id": 10}
+{"abstract_id": "24947817", "label": "methods", "text": "The trial has @ % power with a type I error rate of @ % to detect a @ % increase in primary outcome between the tamsulosin and nifedipine treatment groups .", "sentence_id": 11}
+{"abstract_id": "24434889", "label": "objective", "text": "The aim of the present study was to evaluate the effects of upper thoracic manipulation on pain in subjects with temporomandibular disorder .", "sentence_id": 0}
+{"abstract_id": "24434889", "label": "methods", "text": "Thirty-two women with a diagnosis of temporomandibular disorder were randomly allocated to an experimental group ( n = @ ) , submitted to upper thoracic manipulation , and a placebo group ( n = @ ) , submitted to a procedure in the thoracic region with no therapeutic effect .", "sentence_id": 1}
+{"abstract_id": "24434889", "label": "methods", "text": "All volunteers underwent an evaluation of pain in the masticatory muscles and the temporomandibular joint using an algometer and the visual analog scale before and immediately after the procedure as well as after @-@ hrs .", "sentence_id": 2}
+{"abstract_id": "24434889", "label": "methods", "text": "Two-way repeated-measures analysis of variance was used for the intragroup and intergroup analyses , with the level of significance set to @ % ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "24434889", "label": "methods", "text": "Cohen d was calculated for the determination of the effect size .", "sentence_id": 4}
+{"abstract_id": "24434889", "label": "results", "text": "No significant group-by-time interaction was found ( P > @ ) for algometry in any analysis , and Cohen d revealed no significant effect of the treatment .", "sentence_id": 5}
+{"abstract_id": "24434889", "label": "results", "text": "Moreover , no significant group-by-time interaction was found for facial pain intensity determined using the visual analog scale ( P > @ ) , and Cohen d also revealed no significant effect of the treatment regarding this variable .", "sentence_id": 6}
+{"abstract_id": "24434889", "label": "conclusions", "text": "On the basis of the present findings , upper thoracic spinal manipulation does not lead to a reduction in pain in women with temporomandibular disorder .", "sentence_id": 7}
+{"abstract_id": "25089277", "label": "objective", "text": "This study investigates the changes in hemorheologic parameters resulting from exercise followed by a standard meal .", "sentence_id": 0}
+{"abstract_id": "25089277", "label": "methods", "text": "In twelve moderately active men a period of exercise on a bicycle ergometer for @ min at @ % VO@max was followed by a test meal or by @ min rest .", "sentence_id": 1}
+{"abstract_id": "25089277", "label": "methods", "text": "Venous blood was sampled for further analysis at baseline , after exercise , and after the meal/rest period .", "sentence_id": 2}
+{"abstract_id": "25089277", "label": "results", "text": "The elongation index ( EI ) was reduced and a marked rise in plasma viscosity was observed after exercise .", "sentence_id": 3}
+{"abstract_id": "25089277", "label": "results", "text": "A significant decrease in half time of total aggregation ( T @/@ ) and a rise in aggregation index ( AI ) after exercise were observed ; however , after the postexercise period these changes were reversed .", "sentence_id": 4}
+{"abstract_id": "25089277", "label": "conclusions", "text": "The present study demonstrates that physical exercise causes several changes in blood rheology parameters , such as an increase of blood viscosity , a decrease in EI and an increase in AI , and a fall in the T @/@ values .", "sentence_id": 5}
+{"abstract_id": "25089277", "label": "conclusions", "text": "The meal eaten in the postexercise period caused a further reduction in EI values indicating higher red cell rigidity , but not in plasma viscosity or aggregations indices .", "sentence_id": 6}
+{"abstract_id": "25089277", "label": "conclusions", "text": "Such alterations in hemorheologic parameters should not impair the function of the cardiovascular system in fit and healthy people but it could constitute a serious risk under various pathophysiological conditions .", "sentence_id": 7}
+{"abstract_id": "25154949", "label": "objective", "text": "Proximal and distal ( mid-thigh ) ultrasound-guided continuous adductor canal block techniques have been described but not yet compared , and infusion benefits or side effects may be determined by catheter location .", "sentence_id": 0}
+{"abstract_id": "25154949", "label": "objective", "text": "We hypothesized that proximal placement will result in faster onset of saphenous nerve anesthesia , without additional motor block , compared to a distal technique .", "sentence_id": 1}
+{"abstract_id": "25154949", "label": "methods", "text": "Preoperatively , patients receiving an ultrasound-guided nonstimulating adductor canal catheter for knee arthroplasty were randomly assigned to either proximal or distal insertion .", "sentence_id": 2}
+{"abstract_id": "25154949", "label": "methods", "text": "A local anesthetic bolus was administered via the catheter after successful placement .", "sentence_id": 3}
+{"abstract_id": "25154949", "label": "methods", "text": "The primary outcome was the time to achieve complete sensory anesthesia in the saphenous nerve distribution .", "sentence_id": 4}
+{"abstract_id": "25154949", "label": "methods", "text": "Secondary outcomes included procedural time , procedure-related pain and complications , postoperative pain , opioid consumption , and motor weakness .", "sentence_id": 5}
+{"abstract_id": "25154949", "label": "results", "text": "Proximal insertion ( n = @ ) took a median ( @th-@th percentiles ) of @ ( @-@ @ ) minutes versus @ ( @-@ @ ) minutes for distal insertion ( n = @ ; P = @ ) to anesthetize the medial calf .", "sentence_id": 6}
+{"abstract_id": "25154949", "label": "results", "text": "Only @ of @ ( @ % ) and @ of @ ( @ % ) patients in the proximal and distal groups , respectively , developed anesthesia at both the medial calf and top of the patella ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25154949", "label": "results", "text": "Bolus-induced motor weakness occurred in @ of @ ( @ % ) and @ of @ ( @ % ) patients in the proximal and distal groups ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25154949", "label": "results", "text": "Ten of @ patients ( @ % ) in the distal group required intravenous morphine postoperatively , compared to @ of @ ( @ % ) in the proximal group ( P = @ ) , but there were no differences in other secondary outcomes .", "sentence_id": 9}
+{"abstract_id": "25154949", "label": "conclusions", "text": "Continuous adductor canal blocks can be performed reliably at both proximal and distal locations .", "sentence_id": 10}
+{"abstract_id": "25154949", "label": "conclusions", "text": "The proximal approach may offer minor analgesic and logistic advantages without an increase in motor block .", "sentence_id": 11}
+{"abstract_id": "24917557", "label": "background", "text": "The health-promoting properties of apples are directly related to the biologically active compounds that they contain , such as polyphenols .", "sentence_id": 0}
+{"abstract_id": "24917557", "label": "background", "text": "The objective of this study was to prepare a low-sugar , fibre - and phlorizin-enriched powder from unripe apples and to gain insight regarding its anti-hyperglycaemic activity in healthy volunteers .", "sentence_id": 1}
+{"abstract_id": "24917557", "label": "results", "text": "The unripe apples ( Malus domestica Borkh . )", "sentence_id": 2}
+{"abstract_id": "24917557", "label": "results", "text": "were collected @ days after the full bloom day ; blanched and pressed to obtain apple pomace which was then processed with a food cutter , oven-dried and milled to prepare apple powder .", "sentence_id": 3}
+{"abstract_id": "24917557", "label": "results", "text": "The concentrations of total sugars , water-soluble pectin and phlorizin in the apple preparation were @ , @ and @ g kg ( -@ ) , respectively .", "sentence_id": 4}
+{"abstract_id": "24917557", "label": "results", "text": "Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test ( OGTT ) in six healthy volunteers by reducing the postprandial glucose response at @ to @ min by approximately two-fold ( P < @ ) and by increasing urinary glucose excretion during the @ - to @-h interval of the OGTT by five-fold ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24917557", "label": "conclusions", "text": "The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health-promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes .", "sentence_id": 6}
+{"abstract_id": "25539281", "label": "objective", "text": "The purpose of this study was to determine parents ' knowledge about pediatric fluoroscopic procedures and potential risk from ionizing radiation before and after being given an informational brochure .", "sentence_id": 0}
+{"abstract_id": "25539281", "label": "methods", "text": "We reviewed responses from @ randomly selected participants who were parents or guardians of pediatric patients undergoing diagnostic fluoroscopic examinations .", "sentence_id": 1}
+{"abstract_id": "25539281", "label": "methods", "text": "A questionnaire assessed participants ' knowledge of the procedure , radiation exposure , and whether their child had a prior examination before and after receiving an informational brochure .", "sentence_id": 2}
+{"abstract_id": "25539281", "label": "methods", "text": "In a feedback survey , participants rated the brochure .", "sentence_id": 3}
+{"abstract_id": "25539281", "label": "methods", "text": "A repeated measures mixed model was used to evaluate the effect of the brochure on the participants ' knowledge .", "sentence_id": 4}
+{"abstract_id": "25539281", "label": "results", "text": "Participant demographics were women ( @ % ) , English speaking ( @ % ) , white ( @ % ) , and education higher than @th grade ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25539281", "label": "results", "text": "The median age of patients undergoing the fluoroscopic examination was @ years .", "sentence_id": 6}
+{"abstract_id": "25539281", "label": "results", "text": "Participant knowledge increased ( p < @ ) between pre - and postbrochure ( least-squares means ) for those without a previous examination from @ to @ ( total test score ) and from @ to @ for those with a prior examination .", "sentence_id": 7}
+{"abstract_id": "25539281", "label": "results", "text": "The proportion of correct answers was higher ( p < @ ) postbrochure compared with pre-brochure in areas of examination name ( @ % vs @ % ) , procedure details ( @ % vs @ % ) ; use of radiation ( @ % vs @ % ) , and radiation dose comparison ( @ % vs @ % ) .", "sentence_id": 8}
+{"abstract_id": "25539281", "label": "results", "text": "Overall , @ % ( @/@ ) rated the brochure `` good '' or `` great '' ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25539281", "label": "conclusions", "text": "An informational brochure given to participants before their child 's fluoroscopic procedure improved their knowledge of the examination and radiation exposure .", "sentence_id": 10}
+{"abstract_id": "25539281", "label": "conclusions", "text": "No participants refused their child 's examination .", "sentence_id": 11}
+{"abstract_id": "24491463", "label": "background", "text": "It remains to be determined if perioperative systemic magnesium can improve postoperative quality of recovery of patients undergoing ambulatory procedures .", "sentence_id": 0}
+{"abstract_id": "24491463", "label": "background", "text": "The main objective of the current investigation was to evaluate the effect of systemic magnesium on postoperative quality of recovery in patients undergoing outpatient segmental mastectomies .", "sentence_id": 1}
+{"abstract_id": "24491463", "label": "methods", "text": "The study was a prospective randomized , double-blind , placebo-controlled , clinical trial .", "sentence_id": 2}
+{"abstract_id": "24491463", "label": "methods", "text": "Female subjects were randomized to receive intravenous magnesium ( MgSO@ @mg/kg in @ mL of normal saline over @ min before anesthesia induction , followed by an infusion of @ mg/kg/hour ) or the same volume of saline .", "sentence_id": 3}
+{"abstract_id": "24491463", "label": "methods", "text": "The primary outcome was the Quality of Recovery @ ( QOR-@ ) questionnaire at @ hours after surgery .", "sentence_id": 4}
+{"abstract_id": "24491463", "label": "results", "text": "@ subjects were recruited and @ completed the study .", "sentence_id": 5}
+{"abstract_id": "24491463", "label": "results", "text": "Patients in the magnesium group had better global Quality of Recovery scores compared with the saline group , with a median difference of @ ( @ % CI , @ to @ ) , P < @ .", "sentence_id": 6}
+{"abstract_id": "24491463", "label": "results", "text": "After discharge from hospital , subjects in the magnesium group required less oral opioids , median ( IQR ) of @ ( @ to @ ) ( oral milligrams of morphine equivalents ) than the saline group , @ ( @ to @ ) ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24491463", "label": "results", "text": "The postoperative systemic magnesium concentrations were substantially higher in the magnesium group , @ @ mmol/L compared to control , @ @ mmol/L , P < @ .", "sentence_id": 8}
+{"abstract_id": "24491463", "label": "results", "text": "Simple linear regression demonstrated a direct linear relationship between the postoperative systemic magnesium concentrations and @ hour postoperative quality of recovery scores ( P = @ ) , and also an inverse relationship with pain burden in the postoperative care unit ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24491463", "label": "conclusions", "text": "Systemic magnesium improves postoperative quality of recovery in patients undergoing outpatient segmental mastectomy .", "sentence_id": 10}
+{"abstract_id": "24491463", "label": "conclusions", "text": "Systemic magnesium is a safe , inexpensive , efficacious strategy to improve quality of recovery after ambulatory surgery .", "sentence_id": 11}
+{"abstract_id": "24370820", "label": "objective", "text": "We hypothesized that , after axillary block , positioning the patient in a lateral position with the injected side down and simultaneously in a @ Trendelenburg position will increase the success rate and quality of the block .", "sentence_id": 0}
+{"abstract_id": "24370820", "label": "methods", "text": "Fifty patients with chronic renal failure ( ASA @-@ ) scheduled for arteriovenous fistula surgery were included in this study .", "sentence_id": 1}
+{"abstract_id": "24370820", "label": "methods", "text": "In all patients , @-@ ml of @ % levobupivacaine were injected into the axillary sheath .", "sentence_id": 2}
+{"abstract_id": "24370820", "label": "methods", "text": "The block was performed as three injections ( multiple injection technique ) with the arm in @ abduction and @ flexion in the supine position .", "sentence_id": 3}
+{"abstract_id": "24370820", "label": "methods", "text": "Patients were randomly allocated to two groups .", "sentence_id": 4}
+{"abstract_id": "24370820", "label": "methods", "text": "Group I ( n = @ ) patients were kept in the supine position after the block .", "sentence_id": 5}
+{"abstract_id": "24370820", "label": "methods", "text": "Group II ( n = @ ) patients were positioned laterally after the block with the injected arm down and in a @ Trendelenburg position .", "sentence_id": 6}
+{"abstract_id": "24370820", "label": "methods", "text": "Sensory and motor block were evaluated at @ , @ , @ , @ , @ , @ , @ , and @ min after the administration of the block .", "sentence_id": 7}
+{"abstract_id": "24370820", "label": "methods", "text": "Thus , the patients in group II were evaluated in a lateral position during the first @ min .", "sentence_id": 8}
+{"abstract_id": "24370820", "label": "methods", "text": "Throughout the surgery and the recovery period , sensory and motor block were evaluated at @-min intervals .", "sentence_id": 9}
+{"abstract_id": "24370820", "label": "results", "text": "There were no significant intergroup differences in the effects on radial , ulnar , median , and musculoskeletal nerve blockade .", "sentence_id": 10}
+{"abstract_id": "24370820", "label": "results", "text": "Thirty minutes after the injection , the patients in group II had higher levels of sensory axillary nerve blockade .", "sentence_id": 11}
+{"abstract_id": "24370820", "label": "results", "text": "Subscapular and thoracodorsal nerve motor block were not detected in group I , while @ % of the patients in group II experienced blockade of both of these nerves ( p < @ ) .", "sentence_id": 12}
+{"abstract_id": "24370820", "label": "conclusions", "text": "We conclude that , for patients undergoing an axillary block , positioning the patient laterally with the injected side down and in a @ Trendelenburg position increases the success rate and quality of the block .", "sentence_id": 13}
+{"abstract_id": "24950280", "label": "objective", "text": "The primary objective was to compare overall survival ( OS ) in patients with colorectal cancer ( CRC ) with nonresectable liver-only metastases treated by liver transplantation or chemotherapy .", "sentence_id": 0}
+{"abstract_id": "24950280", "label": "background", "text": "CRC is the third most common cancer worldwide .", "sentence_id": 1}
+{"abstract_id": "24950280", "label": "background", "text": "About @ % of patients will develop metastatic disease primarily to the liver and the lung .", "sentence_id": 2}
+{"abstract_id": "24950280", "label": "background", "text": "The majority of patients with liver metastases receive palliative chemotherapy , with a median OS of trial patients of about @ years , and less than @ % are alive at @ years .", "sentence_id": 3}
+{"abstract_id": "24950280", "label": "methods", "text": "Patients with nonresectable liver-only CRC metastases underwent liver transplantation in the SECA study ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24950280", "label": "methods", "text": "Disease-free survival ( DFS ) and OS of patients included in the SECA study were compared with progression-free survival ( PFS ) and OS in a similar cohort of CRC patients with liver-only disease included in a first-line chemotherapy study , the NORDIC VII study ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "24950280", "label": "methods", "text": "PFS/DFS and OS were estimated by the Kaplan-Meier method .", "sentence_id": 6}
+{"abstract_id": "24950280", "label": "results", "text": "DFS/PFS in both groups were @ to @ months .", "sentence_id": 7}
+{"abstract_id": "24950280", "label": "results", "text": "However , a dramatic difference in OS was observed .", "sentence_id": 8}
+{"abstract_id": "24950280", "label": "results", "text": "The @-year OS rate was @ % in patients undergoing liver transplantation compared with @ % in patients starting first-line chemotherapy .", "sentence_id": 9}
+{"abstract_id": "24950280", "label": "results", "text": "The reason for the large difference in OS despite similar DFS/PFS is likely different metastatic patterns at relapse/progression .", "sentence_id": 10}
+{"abstract_id": "24950280", "label": "results", "text": "Relapse in the liver transplantation group was often detected as small , slowly growing lung metastases , whereas progression of nonresectable liver metastases was observed in the chemotherapy group .", "sentence_id": 11}
+{"abstract_id": "24950280", "label": "conclusions", "text": "Compared with chemotherapy , liver transplantation resulted in a marked increased OS in CRC patients with nonresectable liver-only metastases .", "sentence_id": 12}
+{"abstract_id": "26076387", "label": "background", "text": "The I-gel ( IG ) supraglottic airway device is a reliable way to establish an airway .", "sentence_id": 0}
+{"abstract_id": "26076387", "label": "background", "text": "Its large ventilation lumen allows for easy passage of an endotracheal tube .", "sentence_id": 1}
+{"abstract_id": "26076387", "label": "background", "text": "With the use of a flexible bronchoscope , the IG offers a good visualization of the laryngeal inlet .", "sentence_id": 2}
+{"abstract_id": "26076387", "label": "background", "text": "This prospective randomized study aims to compare the success rate of flexible bronchoscope-guided tracheal intubation using either the IG or the LMA-Fastrach ( FT ) laryngeal masks .", "sentence_id": 3}
+{"abstract_id": "26076387", "label": "methods", "text": "One hundred twenty patients requiring general anesthesia were randomized to @ of the @ study groups : IG or FT. After anesthesia induction , the assigned laryngeal mask was inserted to obtain adequate ventilation .", "sentence_id": 4}
+{"abstract_id": "26076387", "label": "methods", "text": "We then proceeded to a flexible bronchoscope-guided intubation through the supraglottic device .", "sentence_id": 5}
+{"abstract_id": "26076387", "label": "methods", "text": "Tracheal intubation and laryngeal mask insertion success rates were noted , as well as the time required for these manipulations .", "sentence_id": 6}
+{"abstract_id": "26076387", "label": "methods", "text": "The view of the laryngeal inlet was graded for each intubation attempt .", "sentence_id": 7}
+{"abstract_id": "26076387", "label": "results", "text": "Sixty patients were assigned to each study group .", "sentence_id": 8}
+{"abstract_id": "26076387", "label": "results", "text": "The intubation success rates were similar between the IG and the FT groups ( @ % vs @ % at first attempt ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "26076387", "label": "results", "text": "The times required for tracheal intubation were significantly lower in the IG group ( @ @ seconds vs @ @ seconds ; P < @ ) .", "sentence_id": 10}
+{"abstract_id": "26076387", "label": "results", "text": "Glottic visualization was better in the IG group , with a significantly higher percentage of grade @ visualization ( @ % vs @ % ; P < @ ) and a lower percentage of grade @ visualization ( @ % vs @ % ; P < @ ) , than that in the FT group .", "sentence_id": 11}
+{"abstract_id": "26076387", "label": "conclusions", "text": "The use of the IG supraglottic airway device as a conduit for flexible bronchoscope-guided tracheal intubation results in a success rate equivalent to the use of the LMA-FT .", "sentence_id": 12}
+{"abstract_id": "26076387", "label": "conclusions", "text": "However , the IG allows for shorter intubation times and a better visualization of the glottic opening compared with the LMA-FT .", "sentence_id": 13}
+{"abstract_id": "24638843", "label": "objective", "text": "Critically ill patients are at risk of venous thrombosis , and therefore guidelines recommend daily thromboprophylaxis .", "sentence_id": 0}
+{"abstract_id": "24638843", "label": "objective", "text": "Deep vein thrombosis ( DVT ) commonly occurs in the lower extremities but can occur in other sites including the head and neck , trunk , and upper extremities .", "sentence_id": 1}
+{"abstract_id": "24638843", "label": "objective", "text": "The risk of nonleg deep venous thromboses ( NLDVTs ) , predisposing factors , and the association between NLDVTs and pulmonary embolism ( PE ) or death are unclear .", "sentence_id": 2}
+{"abstract_id": "24638843", "label": "objective", "text": "To describe the frequency , anatomical location , risk factors , management , and consequences of NLDVTs in a large cohort of medical-surgical critically ill adults .", "sentence_id": 3}
+{"abstract_id": "24638843", "label": "methods", "text": "A nested prospective cohort study in the setting of secondary and tertiary care intensive care units ( ICUs ) .", "sentence_id": 4}
+{"abstract_id": "24638843", "label": "methods", "text": "The study population comprised @ patients , who were expected to remain in the ICU for at least @ days and were enrolled in a randomized clinical trial of dalteparin vs standard heparin for thromboprophylaxis .", "sentence_id": 5}
+{"abstract_id": "24638843", "label": "methods", "text": "The proportion of patients who had NLDVTs , the mean number per patient , and the anatomical location .", "sentence_id": 6}
+{"abstract_id": "24638843", "label": "methods", "text": "We characterized NLDVTs as prevalent or incident ( identified within @ hours of ICU admission or thereafter ) and whether they were catheter related or not .", "sentence_id": 7}
+{"abstract_id": "24638843", "label": "methods", "text": "We used multivariable regression models to evaluate risk factors for NLDVT and to examine subsequent anticoagulant therapy , associated PE , and death .", "sentence_id": 8}
+{"abstract_id": "24638843", "label": "methods", "text": "RESULTS Of @ trial patients , @ ( @ % ) developed @ or more non-leg vein thromboses ( superficial or deep , proximal or distal ) .", "sentence_id": 9}
+{"abstract_id": "24638843", "label": "methods", "text": "Thromboses were more commonly incident ( n = @ -LSB- @ % -RSB- ) than prevalent ( n = @ -LSB- @ % -RSB- ) ( P < @ ) and more often deep ( n = @ -LSB- @ % -RSB- ) than superficial ( n = @ -LSB- @ % -RSB- ) ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24638843", "label": "methods", "text": "Cancer was the only independent predictor of incident NLDVT ( hazard ratio -LSB- HR -RSB- , @ ; @ % CI , @-@ @ ) .", "sentence_id": 11}
+{"abstract_id": "24638843", "label": "methods", "text": "After adjusting for Acute Physiology and Chronic Health Evaluation ( APACHE ) II scores , personal or family history of venous thromboembolism , body mass index , vasopressor use , type of thromboprophylaxis , and presence of leg DVT , NLDVTs were associated with an increased risk of PE ( HR , @ ; @ % CI , @-@ @ ) .", "sentence_id": 12}
+{"abstract_id": "24638843", "label": "methods", "text": "Nonleg DVTs were not associated with ICU mortality ( HR , @ ; @ % CI , @-@ @ ) in a model adjusting for age , APACHE II , vasopressor use , mechanical ventilation , renal replacement therapy , and platelet count below @ @ ( @ ) / L. CONCLUSIONS AND RELEVANCE Despite universal heparin thromboprophylaxis , nonleg thromboses are found in @ % of medical-surgical critically ill patients , primarily in deep veins and proximal veins .", "sentence_id": 13}
+{"abstract_id": "24638843", "label": "methods", "text": "Patients who have a malignant condition may have a significantly higher risk of developing NLDVT , and patients with NLDVT , compared with those without , appeared to be at higher risk of PE but not higher risk of death .", "sentence_id": 14}
+{"abstract_id": "24899242", "label": "background", "text": "Osteoarthritis is a leading cause of disability in developed nations .", "sentence_id": 0}
+{"abstract_id": "24899242", "label": "background", "text": "In Australia it afflicts @ % of the adult population .", "sentence_id": 1}
+{"abstract_id": "24899242", "label": "background", "text": "Total joint arthroplasty is considered the treatment of choice for end stage osteoarthritis .", "sentence_id": 2}
+{"abstract_id": "24899242", "label": "background", "text": "The number of total joint arthroplasties undertaken in Australia has doubled over the last decade ( more than @,@ procedures in @ ) .", "sentence_id": 3}
+{"abstract_id": "24899242", "label": "background", "text": "The incidence of pre-operative psychological distress in this group of patients is reported between @ % and @ % and pre-operative psychological distress is associated with poorer pain and functional outcomes after surgery .", "sentence_id": 4}
+{"abstract_id": "24899242", "label": "background", "text": "This study will use a mindfulness-based psychological intervention to enhance outcomes in people undergoing total joint arthroplasty and , in addition , will test hypotheses about coping with chronic illness in an aged population .", "sentence_id": 5}
+{"abstract_id": "24899242", "label": "background", "text": "This study is the first of its kind and will provide a greater understanding of the role of a mental health enhancement program on the physical recovery of total joint arthroplasty patients .", "sentence_id": 6}
+{"abstract_id": "24899242", "label": "methods", "text": "One hundred and fifty people with end-stage arthritis on the waiting list for total hip or knee arthroplasty will be recruited and randomly allocated to one of two groups using computer-generated block randomisation .", "sentence_id": 7}
+{"abstract_id": "24899242", "label": "methods", "text": "A randomised controlled trial adhering to CONSORT guidelines will evaluate the efficacy of a mindfulness training program ( weekly group-based classes in mindfulness practice , @ hours , for @weeks plus a @-hour Saturday session in Week @ ) prior to total joint arthroplasty , compared to a `` standard care '' group who will undergo routine total joint arthroplasty .", "sentence_id": 8}
+{"abstract_id": "24899242", "label": "methods", "text": "Primary outcomes will be evaluated by a blinded examiner at baseline , @ and @months post-surgery , using a validated self-reported pain and physical function scale .", "sentence_id": 9}
+{"abstract_id": "24899242", "label": "methods", "text": "Secondary outcomes will include i ) a range of validated measures of psychological wellbeing and ii ) health economic analysis .", "sentence_id": 10}
+{"abstract_id": "24899242", "label": "methods", "text": "All analyses will be conducted on an intention to treat basis using linear regression models .", "sentence_id": 11}
+{"abstract_id": "24899242", "label": "methods", "text": "Health economic modelling will be applied to estimate the potential cost-effectiveness of mindfulness training and total joint arthroplasty .", "sentence_id": 12}
+{"abstract_id": "25418079", "label": "objective", "text": "The objective of this study was to evaluate the effectiveness of nystatin and Biotne ( ) mouthwash Oral Rinse for controlling Candida in total laryngectomy ( TL ) patients with a tracheosophageal voice prosthesis ( TEP ) because Biotne ( ) mouthwash Oral Rinse is a less costly alternative to nystatin and requires less adherence time .", "sentence_id": 0}
+{"abstract_id": "25418079", "label": "methods", "text": "Randomized , unblinded , crossover trial .", "sentence_id": 1}
+{"abstract_id": "25418079", "label": "methods", "text": "Twenty-one TL patients were randomized to receive nystatin followed by Biotne ( ) mouthwash Oral Rinse , or the reverse order , after a basic oral-care phase ( i.e. , brushing teeth , cleaning dentures ) .", "sentence_id": 2}
+{"abstract_id": "25418079", "label": "methods", "text": "A Provox ( ) @ , @ French TEP , which is an indwelling silicone voice prosthesis , was placed at the beginning of each phase .", "sentence_id": 3}
+{"abstract_id": "25418079", "label": "methods", "text": "Patients were provided with oral care instructions at randomization and medication-specific instructions with each treatment 's initiation .", "sentence_id": 4}
+{"abstract_id": "25418079", "label": "methods", "text": "TEPs were processed and evaluated for Candida growth as colony-forming units ( CFUs ) .", "sentence_id": 5}
+{"abstract_id": "25418079", "label": "methods", "text": "Wilcoxon signed-rank tests were used for comparisons between treatments .", "sentence_id": 6}
+{"abstract_id": "25418079", "label": "results", "text": "Fifteen patients were available for comparisons of Candida counts ( @ received nystatin ; @ received Biotne ( ) mouthwash first ) .", "sentence_id": 7}
+{"abstract_id": "25418079", "label": "results", "text": "Overall , the median log@ ( CFUs ) remained high regardless of treatment ( no medication : @ ; nystatin : @ ; Biotne ( ) mouthwash : @ ) .", "sentence_id": 8}
+{"abstract_id": "25418079", "label": "results", "text": "However , the median counts for both nystatin and Biotne ( ) mouthwash Oral Rinse were lower than those for no medication ( difference -LSB- -RSB- : -@ and -@ , respectively ) , although only nystatin was significantly lower ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25418079", "label": "results", "text": "There was no significant difference between the two treatments ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25418079", "label": "results", "text": "Overall , median medication-adherence was high ( @ % ) , and Biotne ( ) mouthwash adherence was significantly higher than that of nystatin ( : @ % ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25418079", "label": "conclusions", "text": "Nystatin and Biotne ( ) mouthwash Oral Rinse had similar CFU levels , with nystatin showing a significant improvement over usual oral care .", "sentence_id": 12}
+{"abstract_id": "25418079", "label": "conclusions", "text": "Biotne ( ) mouthwash is a less costly alternative to nystatin , with a less complex treatment protocol that might make it preferable to patients and clinicians .", "sentence_id": 13}
+{"abstract_id": "25759551", "label": "objective", "text": "To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy .", "sentence_id": 0}
+{"abstract_id": "25759551", "label": "methods", "text": "We prospectively enrolled and analyzed @ patients who were at high risk for esophageal cancer .", "sentence_id": 1}
+{"abstract_id": "25759551", "label": "methods", "text": "All patients were divided into two groups : a magnifying narrow band imaging group , and a lugol chromoendoscopy group , for comparison of adverse symptoms .", "sentence_id": 2}
+{"abstract_id": "25759551", "label": "methods", "text": "Esophageal cancer screening was performed on withdrawal of the endoscope .", "sentence_id": 3}
+{"abstract_id": "25759551", "label": "methods", "text": "The primary endpoint was a score on a visual analogue scale for heartburn after the examination .", "sentence_id": 4}
+{"abstract_id": "25759551", "label": "methods", "text": "The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations , change in vital signs , total procedure time , and esophageal observation time .", "sentence_id": 5}
+{"abstract_id": "25759551", "label": "results", "text": "The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group ( P = @ , @ , respectively , ANOVA for repeated measures ) .", "sentence_id": 6}
+{"abstract_id": "25759551", "label": "results", "text": "The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group .", "sentence_id": 7}
+{"abstract_id": "25759551", "label": "results", "text": "There was no significant difference between the two groups with respect to other vital sign .", "sentence_id": 8}
+{"abstract_id": "25759551", "label": "results", "text": "The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group ( @ @ vs @ @ , P = @ , @ @ vs @ @ , P < @ , respectively ) .", "sentence_id": 9}
+{"abstract_id": "25759551", "label": "conclusions", "text": "Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy .", "sentence_id": 10}
+{"abstract_id": "25759551", "label": "conclusions", "text": "Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically .", "sentence_id": 11}
+{"abstract_id": "24451221", "label": "background", "text": "As traditional methods have become increasingly difficult , the Internet offers a mechanism for conducting survey research quickly and efficiently .", "sentence_id": 0}
+{"abstract_id": "24451221", "label": "background", "text": "However , the validity of this research depends on the ability of respondents to accurately report health status .", "sentence_id": 1}
+{"abstract_id": "24451221", "label": "background", "text": "We used a large Internet-based inflammatory bowel disease ( IBD ) cohort to validate self-reported IBD against physician reports .", "sentence_id": 2}
+{"abstract_id": "24451221", "label": "methods", "text": "Between June @ , @ , and April @ , @ , all participants of CCFA Partners ( n = @ ) were invited to participate , and @ were selected by random stratified sampling .", "sentence_id": 3}
+{"abstract_id": "24451221", "label": "methods", "text": "We sent physicians a survey to confirm IBD diagnosis and characteristics .", "sentence_id": 4}
+{"abstract_id": "24451221", "label": "methods", "text": "We used descriptive statistics to compare data .", "sentence_id": 5}
+{"abstract_id": "24451221", "label": "results", "text": "A total of @ participants ( @ % ) indicated interest .", "sentence_id": 6}
+{"abstract_id": "24451221", "label": "results", "text": "Of @ selected , @ ( @ % ) consented , and physician reports were obtained for @ ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "24451221", "label": "results", "text": "Physicians confirmed IBD status in @ ( @ % ) and type in @ ( @ % of confirmed ) .", "sentence_id": 8}
+{"abstract_id": "24451221", "label": "results", "text": "The matching between patient and physician reports for Crohn 's disease ( CD ) was @ % for disease location , @ % for the presence of perianal disease , and @ % for disease behavior .", "sentence_id": 9}
+{"abstract_id": "24451221", "label": "results", "text": "For ulcerative colitis ( UC ) , disease location matched @ % of the time .", "sentence_id": 10}
+{"abstract_id": "24451221", "label": "results", "text": "Physician reports confirmed the status of ever having bowel surgery for @ % of CD and @ % for UC and confirmed current pouch or ostomy in @ % of CD and @ % of UC .", "sentence_id": 11}
+{"abstract_id": "24451221", "label": "conclusions", "text": "Self-reported IBD in CCFA Partners is highly accurate , and participants are willing to release medical records for research .", "sentence_id": 12}
+{"abstract_id": "24451221", "label": "conclusions", "text": "Self-reported phenotypic characteristics were less valid .", "sentence_id": 13}
+{"abstract_id": "24451221", "label": "conclusions", "text": "The validity of IBD diagnoses among the participants of CCFA Partners supports the use of this cohort for patient-centered outcome research .", "sentence_id": 14}
+{"abstract_id": "24781960", "label": "objective", "text": "In type @ diabetes mellitus ( T@DM ) , team management using protocols with regular feedback improves clinical outcomes , although suboptimal self-management and psychological distress remain significant challenges .", "sentence_id": 0}
+{"abstract_id": "24781960", "label": "objective", "text": "To investigate if frequent contacts through a telephone-based peer support program ( Peer Support , Empowerment , and Remote Communication Linked by Information Technology -LSB- PEARL -RSB- ) would improve cardiometabolic risk and health outcomes by enhancing psychological well-being and self-care in patients receiving integrated care implemented through a web-based multicomponent quality improvement program ( JADE -LSB- Joint Asia Diabetes Evaluation -RSB- ) .", "sentence_id": 1}
+{"abstract_id": "24781960", "label": "methods", "text": "Between @ and @ , @ of @ Hong Kong Chinese patients with T@DM from @ publicly funded hospital-based diabetes centers were randomized to the JADE+PEARL ( n = @ ) or JADE ( n = @ ) groups , with comprehensive assessment at @ and @ months .", "sentence_id": 2}
+{"abstract_id": "24781960", "label": "methods", "text": "Thirty-three motivated patients with well-controlled T@DM received @ hours of training ( four @-hour workshops ) to become peer supporters , with @ patients assigned to each .", "sentence_id": 3}
+{"abstract_id": "24781960", "label": "methods", "text": "Peer supporters called their peers at least @ times , guided by a checklist .", "sentence_id": 4}
+{"abstract_id": "24781960", "label": "methods", "text": "Changes in hemoglobin A ( @c ) ( HbA ( @c ) ) level ( primary ) , proportions of patients with attained treatment targets ( HbA ( @c ) < @ % ; blood pressure < @/@ mm Hg ; low-density lipoprotein cholesterol < @ mmol/L -LSB- to convert to milligrams per deciliter , divide by @ -RSB- ) ( secondary ) , and other health outcomes at month @ .", "sentence_id": 5}
+{"abstract_id": "24781960", "label": "results", "text": "Both groups had similar baseline characteristics ( mean -LSB- SD -RSB- age , @ -LSB- @ -RSB- years ; @ % men ; disease duration , @ -LSB- @ -RSB- years ; HbA ( @c ) level , @ % -LSB- @ % -RSB- ; systolic blood pressure , @ -LSB- @ -RSB- mm Hg ; low-density lipoprotein cholesterol level , @ -LSB- @ -RSB- mmol/L ; @ % cardiovascular-renal complications ; and @ % insulin treated ) .", "sentence_id": 6}
+{"abstract_id": "24781960", "label": "results", "text": "After a mean ( SD ) follow-up period of @ ( @ ) days , @ patients had died , @ had at least @ hospitalization , and @ had repeated comprehensive assessments .", "sentence_id": 7}
+{"abstract_id": "24781960", "label": "results", "text": "On intention-to-treat analysis , both groups had similar reductions in HbA ( @c ) ( JADE+PEARL , @ % -LSB- @ % CI , @ % -@ % -RSB- , vs JADE , @ % -LSB- @ % CI , @ % -@ % -RSB- -LSB- P = @ -RSB- ) and improvements in treatment targets and psychological-behavioral measures .", "sentence_id": 8}
+{"abstract_id": "24781960", "label": "results", "text": "In the JADE+PEARL group , @ % of patients maintained contacts with their peer supporters , with a median of @ calls per patient .", "sentence_id": 9}
+{"abstract_id": "24781960", "label": "results", "text": "Most of the discussion items were related to self-management .", "sentence_id": 10}
+{"abstract_id": "24781960", "label": "conclusions", "text": "In patients with T@DM receiving integrated care , peer support did not improve cardiometabolic risks or psychological well-being .", "sentence_id": 11}
+{"abstract_id": "25229983", "label": "objective", "text": "Resistance to antibiotics is the major cause of treatment failure of Helicobacter pylori ( HP ) infection .", "sentence_id": 0}
+{"abstract_id": "25229983", "label": "objective", "text": "The culture-guided triple therapy ( chosen on the basis of a preliminary in-vitro susceptibility test ) might help to increase treatment success in high antibiotic resistance regions .", "sentence_id": 1}
+{"abstract_id": "25229983", "label": "objective", "text": "The aim of this study was to evaluate the effectiveness of treatment with clarithromycin in patients with clarithromycin-sensitive culture compared with patients treated empirically .", "sentence_id": 2}
+{"abstract_id": "25229983", "label": "methods", "text": "In this prospective and controlled trial , @ naive HP-positive patients were randomized to receive standard triple therapy omeprazole ( @mg twice daily ) , amoxicillin ( @g twice daily ) , and clarithromycin ( @mg twice daily ) for @ days ( OAC ) after antimicrobial susceptibility testing if there was no resistance to clarithromycin ( ClariS ) or empirical @-day OAC for first-line therapy of HP ( ClariNA ) .", "sentence_id": 3}
+{"abstract_id": "25229983", "label": "methods", "text": "Eradication was confirmed using the C-labelled urea breath test @ weeks after therapy .", "sentence_id": 4}
+{"abstract_id": "25229983", "label": "methods", "text": "Our primary outcome was HP eradication .", "sentence_id": 5}
+{"abstract_id": "25229983", "label": "methods", "text": "Treatment adherence and adverse effects were recorded .", "sentence_id": 6}
+{"abstract_id": "25229983", "label": "results", "text": "The effectiveness of eradication by protocol with @-day OAC therapy in the ClariS was @ % -LSB- @ % confidence interval ( CI ) : @-@ @ -RSB- , which was @ % higher than ClariNA @ % ( @ % CI : @-@ @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25229983", "label": "results", "text": "The odds ratio of eradication in ClariS was @ ( @ % CI : @-@ @ ; P < @ by logistic regression ) and the number needed to treat was @ ( @ % CI : @-@ ) .", "sentence_id": 8}
+{"abstract_id": "25229983", "label": "results", "text": "We found no significant difference in the occurrence of adverse effects or in compliance between the two groups .", "sentence_id": 9}
+{"abstract_id": "25229983", "label": "conclusions", "text": "The eradication rate was significantly higher with clarithromycin-based triple therapy for patients with clarithromycin-susceptible HP isolates compared with those for whom no information on the corresponding susceptibility was available ( ClinicalTrials.gov number NCT@ ) .", "sentence_id": 10}
+{"abstract_id": "24955450", "label": "objective", "text": "This study was designed to demonstrate the safety and efficacy of esomeprazole combined with flupentixol/melitracen for the treatment of gastroesophageal reflux disease ( GERD ) patients with emotional disorders .", "sentence_id": 0}
+{"abstract_id": "24955450", "label": "objective", "text": "METHODS Two hundred eighty-nine GERD patients with emotional disorders were divided randomly into two groups : group @ received esomeprazole only ( monotherapy ) and group @ received esomeprazole and flupentixol/melitracen ( combination therapy ) .", "sentence_id": 1}
+{"abstract_id": "24955450", "label": "objective", "text": "The patients ' GERD questionnaire ( GerdQ ) and hospital anxiety and depression ( HAD ) scores were obtained before and after treatment .", "sentence_id": 2}
+{"abstract_id": "24955450", "label": "objective", "text": "Changes in the scores , rates of symptom remission , and adverse effects were compared between the two groups .", "sentence_id": 3}
+{"abstract_id": "24955450", "label": "results", "text": "After @ weeks of treatment , the average decrease in GerdQ score in the combination group ( @ @ ) was significantly greater than that in the monotherapy group ( @ @ ; P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24955450", "label": "results", "text": "Significant differences between the two groups were also found for changes in HAD anxiety scores ( @ @ vs @ @ , P < @ ) , depression scores ( @ @ vs @ @ , P < @ ) , and anxiety-depression scores ( @ @ vs @ @ , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24955450", "label": "results", "text": "The remission of symptoms ( eructation , abdominal pain , anorexia , and other accompanying symptoms ) in the combination group was significantly better than that in the monotherapy group , and no significant difference in the incidence of adverse events was observed between the two groups .", "sentence_id": 6}
+{"abstract_id": "24955450", "label": "conclusions", "text": "The combination therapy has better efficacy than the monotherapy in improving the symptoms of gastroesophageal reflux in patients with emotional disorders .", "sentence_id": 7}
+{"abstract_id": "24955450", "label": "conclusions", "text": "In addition , this combination treatment is safe , with a low incidence of adverse events .", "sentence_id": 8}
+{"abstract_id": "25238785", "label": "background", "text": "Management of acute sore throat poses a significant burden on UK general practices , with almost @ % of registered patients attending their GP with sore throat every year .", "sentence_id": 0}
+{"abstract_id": "25238785", "label": "background", "text": "Nearly half of all patients presenting with acute sore throat are treated with antibiotics , despite their limited effect .", "sentence_id": 1}
+{"abstract_id": "25238785", "label": "background", "text": "In a recent systematic review we demonstrated that a single dose of steroids reduced the severity and time to resolution of sore throat .", "sentence_id": 2}
+{"abstract_id": "25238785", "label": "background", "text": "However , all of the trials included looked at the use of steroids alongside antibiotics and only one was in a primary care setting .", "sentence_id": 3}
+{"abstract_id": "25238785", "label": "background", "text": "This trial aims to assess the efficacy and cost-effectiveness of a single oral dose of corticosteroids on symptoms of sore throat in patients receiving either a delayed antibiotic prescription or no antibiotics at all in UK primary care .", "sentence_id": 4}
+{"abstract_id": "25238785", "label": "methods", "text": "A double-blind , two arm , randomized , placebo controlled trial in adults ( @ years of age ) presenting to primary care with acute sore throat ( < seven days ) .", "sentence_id": 5}
+{"abstract_id": "25238785", "label": "methods", "text": "Participants are recruited on the day of presentation to their GP practice .", "sentence_id": 6}
+{"abstract_id": "25238785", "label": "methods", "text": "GPs or nurses assess eligibility , record baseline clinical features and obtain a throat swab for bacterial culture .", "sentence_id": 7}
+{"abstract_id": "25238785", "label": "methods", "text": "Participants are being randomized to treatment arms at a ratio of @:@ .", "sentence_id": 8}
+{"abstract_id": "25238785", "label": "methods", "text": "Treatment arms will be stratified according to whether patients are being given a delayed antibiotic prescription or no antibiotic prescription and by recruiting centre ( Oxford , Bristol or Southampton ) .", "sentence_id": 9}
+{"abstract_id": "25238785", "label": "methods", "text": "Outcome data is being collected at @ and @ hours via text message or telephone call , from days @ to @ using a patient symptom diary and at one month via a GP notes review .", "sentence_id": 10}
+{"abstract_id": "25238785", "label": "conclusions", "text": "This will be the first randomized controlled trial of oral corticosteroids in adults presenting to primary care with sore throat in the UK , and the first to examine the clinical and cost-effectiveness of oral corticosteroids for the treatment of sore throat in the absence of antibiotics .", "sentence_id": 11}
+{"abstract_id": "25575262", "label": "background", "text": "Postoperative infectious complications in patients undergoing pancreatic surgery are a significant cause for morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "25575262", "label": "background", "text": "Although synbiotics have beneficial effects on human health , their clinical value in surgical patients remains unclear given a paucity of applicable clinical studies .", "sentence_id": 1}
+{"abstract_id": "25575262", "label": "objective", "text": "To determine the impact of perioperative synbiotic therapy on postoperative infectious complications , morbidity and mortality in patients undergoing pancreatic surgery for chronic pancreatitis .", "sentence_id": 2}
+{"abstract_id": "25575262", "label": "methods", "text": "A trial was conducted in patients with chronic calcific pancreatitis undergoing Frey 's procedure .", "sentence_id": 3}
+{"abstract_id": "25575262", "label": "methods", "text": "Group A received a specific synbiotic composition , @ days prior and @ days after the surgery .", "sentence_id": 4}
+{"abstract_id": "25575262", "label": "methods", "text": "Group B received a placebo .", "sentence_id": 5}
+{"abstract_id": "25575262", "label": "methods", "text": "Primary study endpoint was the occurrence of postoperative infection during the first @ days .", "sentence_id": 6}
+{"abstract_id": "25575262", "label": "methods", "text": "Secondary outcome measures were mortality , length of hospital stay , days in intensive care unit , and duration of antibiotic therapy .", "sentence_id": 7}
+{"abstract_id": "25575262", "label": "methods", "text": "Using previously accrued data , with of @ and power @ % , the sample size was calculated as @ patients for each group with a dropout rate of @ % .", "sentence_id": 8}
+{"abstract_id": "25575262", "label": "results", "text": "Of the @ patients enrolled , @ completed the trial -LSB- group A ( n = @ ) and group B ( n = @ ) -RSB- .", "sentence_id": 9}
+{"abstract_id": "25575262", "label": "results", "text": "The incidence of postoperative infectious complications ( @ % vs @ % ; P < @ ) , duration of antibiotics therapy ( P < @ ) , and length of hospital stay ( P < @ ) were significantly lower in the synbiotic group .", "sentence_id": 10}
+{"abstract_id": "25575262", "label": "conclusions", "text": "Synbiotics significantly reduce septic complications , hospital stay , and antibiotic requirement in patients undergoing pancreatic surgery for chronic pancreatitis .", "sentence_id": 11}
+{"abstract_id": "25575262", "label": "conclusions", "text": "Furthermore , basic and clinical research would clarify the underlying mechanisms of their therapeutic effect and define the appropriate conditions for use .", "sentence_id": 12}
+{"abstract_id": "24768221", "label": "background", "text": "Minimally invasive plate osteosynthesis for humeral shaft fractures has been described recently , but there are no randomized studies comparing the clinical results for shoulder function between this technique and locking intramedullary nailing .", "sentence_id": 0}
+{"abstract_id": "24768221", "label": "methods", "text": "A prospective randomized study was performed .", "sentence_id": 1}
+{"abstract_id": "24768221", "label": "methods", "text": "Forty-one humeral shaft fractures ( @ patients ) were randomized to be treated with a minimally invasive plate ( n = @ ) or a locking intramedullary nail ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24768221", "label": "methods", "text": "Clinical and radiographic outcome assessments were conducted at @year postoperatively .", "sentence_id": 3}
+{"abstract_id": "24768221", "label": "methods", "text": "Shoulder function was the primary outcome , as measured by the University of California , Los Angeles Shoulder Scale .", "sentence_id": 4}
+{"abstract_id": "24768221", "label": "methods", "text": "Elbow function was measured by the Broberg-Morrey score , and fracture consolidation and complications were the main secondary outcomes .", "sentence_id": 5}
+{"abstract_id": "24768221", "label": "results", "text": "At @year postoperatively , no significant difference was found with regard to shoulder function according to the University of California , Los Angeles scale between the minimally invasive plate and locking intramedullary nail ( @ points vs @ points , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24768221", "label": "results", "text": "There was also no difference in elbow function ( @ points vs @ points , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24768221", "label": "results", "text": "Complications were similar between the groups , without significant differences regarding infection ( P > @ ) , symptomatic shoulder stiffness ( P = @ ) , and neurapraxia of the lateral cutaneous nerve of the forearm ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24768221", "label": "results", "text": "Fracture union was achieved in all but @ patient ( @ % ) in the intramedullary nail group within @year after the surgical procedure .", "sentence_id": 9}
+{"abstract_id": "24768221", "label": "conclusions", "text": "There is no significant difference in shoulder function between antegrade intramedullary nailing and minimally invasive plate osteosynthesis for the treatment of displaced humeral shaft fractures , despite the limited power of our study .", "sentence_id": 10}
+{"abstract_id": "24621126", "label": "background", "text": "Exposure to particulate matter ( PM ) air pollution especially derived from traffic is associated with increases in cardiorespiratory morbidity and mortality .", "sentence_id": 0}
+{"abstract_id": "24621126", "label": "background", "text": "In this study , we evaluated the ability of novel vehicle cabin air inlet filters to reduce diesel exhaust ( DE ) - induced symptoms and markers of inflammation in human subjects .", "sentence_id": 1}
+{"abstract_id": "24621126", "label": "methods", "text": "Thirty healthy subjects participated in a randomized double-blind controlled crossover study where they were exposed to filtered air , unfiltered DE and DE filtered through two selected particle filters , one with and one without active charcoal .", "sentence_id": 2}
+{"abstract_id": "24621126", "label": "methods", "text": "Exposures lasted for one hour .", "sentence_id": 3}
+{"abstract_id": "24621126", "label": "methods", "text": "Symptoms were assessed before and during exposures and lung function was measured before and after each exposure , with inflammation assessed in peripheral blood five hours after exposures .", "sentence_id": 4}
+{"abstract_id": "24621126", "label": "methods", "text": "In parallel , PM were collected from unfiltered and filtered DE and assessed for their capacity to drive damaging oxidation reactions in a cell-free model , or promote inflammation in A@ cells .", "sentence_id": 5}
+{"abstract_id": "24621126", "label": "results", "text": "The standard particle filter employed in this study reduced PM@ mass concentrations within the exposure chamber by @ % , further reduced to @ % by the inclusion of an active charcoal component .", "sentence_id": 6}
+{"abstract_id": "24621126", "label": "results", "text": "In addition use of the active charcoal filter was associated by a @ % and @ % reduction in NO@ and hydrocarbon concentrations , respectively .", "sentence_id": 7}
+{"abstract_id": "24621126", "label": "results", "text": "As expected , subjects reported more subjective symptoms after exposure to unfiltered DE compared to filtered air , which was significantly reduced by the filter with an active charcoal component .", "sentence_id": 8}
+{"abstract_id": "24621126", "label": "results", "text": "There were no significant changes in lung function after exposures .", "sentence_id": 9}
+{"abstract_id": "24621126", "label": "results", "text": "Similarly diesel exhaust did not elicit significant increases in any of the inflammatory markers examined in the peripheral blood samples @hour post-exposure .", "sentence_id": 10}
+{"abstract_id": "24621126", "label": "results", "text": "Whilst the filters reduced chamber particle concentrations , the oxidative activity of the particles themselves , did not change following filtration with either filter .", "sentence_id": 11}
+{"abstract_id": "24621126", "label": "results", "text": "In contrast , diesel exhaust PM passed through the active charcoal combination filter appeared less inflammatory to A@ cells .", "sentence_id": 12}
+{"abstract_id": "24621126", "label": "conclusions", "text": "A cabin air inlet particle filter including an active charcoal component was highly effective in reducing both DE particulate and gaseous components , with reduced exhaust-induced symptoms in healthy volunteers .", "sentence_id": 13}
+{"abstract_id": "24621126", "label": "conclusions", "text": "These data demonstrate the effectiveness of cabin filters to protect subjects travelling in vehicles from diesel exhaust emissions .", "sentence_id": 14}
+{"abstract_id": "24636210", "label": "background", "text": "Treatment of breast cancer with aromatase inhibitors is associated with damage to bones .", "sentence_id": 0}
+{"abstract_id": "24636210", "label": "background", "text": "NCIC CTG MA @ was an open-label , phase @ , randomised controlled trial in which women with breast cancer were assigned to one of two adjuvant oral aromatase inhibitors-exemestane or anastrozole .", "sentence_id": 1}
+{"abstract_id": "24636210", "label": "background", "text": "We postulated that exemestane-a mildly androgenic steroid-might have a less detrimental effect on bone than non-steroidal anastrozole .", "sentence_id": 2}
+{"abstract_id": "24636210", "label": "background", "text": "In this companion study to MA @ , we compared changes in bone mineral density ( BMD ) in the lumbar spine and total hip between patients treated with exemestane and patients treated with anastrozole .", "sentence_id": 3}
+{"abstract_id": "24636210", "label": "methods", "text": "In MA @ , postmenopausal women with early stage hormone ( oestrogen ) receptor-positive invasive breast cancer were randomly assigned to exemestane @ mg versus anastrozole @ mg , daily .", "sentence_id": 4}
+{"abstract_id": "24636210", "label": "methods", "text": "MA @ B recruited two groups of women from MA @ : those with BMD T-scores of -@ or more ( up to @ SDs below sex-matched , young adult mean ) and those with at least one T-score ( hip or spine ) less than -@ .", "sentence_id": 5}
+{"abstract_id": "24636210", "label": "methods", "text": "Both groups received vitamin D and calcium ; those with baseline T-scores of less than -@ also received bisphosphonates .", "sentence_id": 6}
+{"abstract_id": "24636210", "label": "methods", "text": "The primary endpoints were percent change of BMD at @ years in lumbar spine and total hip for both groups .", "sentence_id": 7}
+{"abstract_id": "24636210", "label": "methods", "text": "We analysed patients according to which aromatase inhibitor and T-score groups they were allocated to but BMD assessments ceased if patients deviated from protocol .", "sentence_id": 8}
+{"abstract_id": "24636210", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , NCT@ .", "sentence_id": 9}
+{"abstract_id": "24636210", "label": "results", "text": "Between April @ , @ , and May @ , @ , @ patients with baseline T-scores of -@ or more were accrued ( @ allocated exemestane , @ anastrozole ) ; and @ patients with baseline T-scores of less than -@ ( @ exemestane , @ anastrozole ) .", "sentence_id": 10}
+{"abstract_id": "24636210", "label": "results", "text": "For patients with T-scores greater than -@ at baseline , mean change of bone mineral density in the spine at @ years did not differ significantly between patients taking exemestane and patients taking anastrozole ( -@ % , @ % CI -@ to @ vs -@ % , @ % CI -@ to -@ ; p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24636210", "label": "results", "text": "Respective mean loss in the hip was -@ % ( @ % CI -@ to -@ ) versus -@ % ( @ % CI -@ to -@ ; p = @ ) .", "sentence_id": 12}
+{"abstract_id": "24636210", "label": "results", "text": "Likewise for those who started with T-scores of less than -@ , mean change of spine bone mineral density at @ years did not differ significantly between the exemestane and anastrozole treatment groups ( @ % , @ % CI -@ to @ vs @ % , @ % CI @ to @ ; p = @ ) , nor did hip bone mineral density ( @ % , @ % CI -@ to @ vs @ % , @ % CI -@ to @ ; p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24636210", "label": "results", "text": "Patients with baseline T-score of -@ or more taking exemestane had two fragility fractures and two other fractures , those taking anastrozole had three fragility fractures and five other fractures .", "sentence_id": 14}
+{"abstract_id": "24636210", "label": "results", "text": "For patients who had baseline T-scores of less than -@ taking exemestane , one had a fragility fracture and four had other fractures , whereas those taking anastrozole had five fragility fractures and one other fracture .", "sentence_id": 15}
+{"abstract_id": "24636210", "label": "conclusions", "text": "Our results demonstrate that adjuvant treatment with aromatase inhibitors can be considered for breast cancer patients who have T-scores less than -@ .", "sentence_id": 16}
+{"abstract_id": "24448036", "label": "objective", "text": "To determine whether medical student intubation proficiency with a neonatal mannequin differs according to weekly or consecutive day practice sessions during a six-week pediatric clerkship .", "sentence_id": 0}
+{"abstract_id": "24448036", "label": "methods", "text": "From July @ through June @ , the authors prospectively randomized @ third-year medical students into three neonatal intubation practice groups : standard ( control ; no practice sessions ) , weekly ( practice once/week for four consecutive weeks ) , or consecutive day ( practice once/day for four consecutive days ) .", "sentence_id": 1}
+{"abstract_id": "24448036", "label": "methods", "text": "At baseline , students performed intubation during individual sessions using a neonatal mannequin ( SimNewB ) .", "sentence_id": 2}
+{"abstract_id": "24448036", "label": "methods", "text": "Two reviewers , blinded to practice group , viewed videotapes of intubations and independently scored students on equipment selection , procedural skill steps , length of intubation attempts ( in seconds ) , and the number of attempts ( up to three ) needed for a successful intubation .", "sentence_id": 3}
+{"abstract_id": "24448036", "label": "methods", "text": "Videotaped individual final assessment intubation sessions during week six were evaluated in the same manner .", "sentence_id": 4}
+{"abstract_id": "24448036", "label": "results", "text": "Students in the weekly and consecutive day practice groups performed better at the final assessment on all variables than students in the standard group ( P < @ ) , but over six weeks , the authors detected no differences between the two distributed practice formats for any outcomes of interest .", "sentence_id": 5}
+{"abstract_id": "24448036", "label": "conclusions", "text": "Practice improved all aspects of neonatal intubation performance , including choosing the correct equipment , properly performing the skill steps , length of time to successful intubation , and success rate , for novice health care providers in a simulation setting .", "sentence_id": 6}
+{"abstract_id": "24448036", "label": "conclusions", "text": "Over six weeks , neither practice format proved superior , but it remains unclear whether one format is superior for learning and skill retention over the long term or in actual practice .", "sentence_id": 7}
+{"abstract_id": "24300595", "label": "background", "text": "Obesity and reduced muscle strength are associated with increased blood pressure ( BP ) .", "sentence_id": 0}
+{"abstract_id": "24300595", "label": "background", "text": "We examined the impact of milk proteins and combined exercise training ( CET ) on BP , arterial function , and muscle strength ( one-repetition maximum ( @-RM ) ) .", "sentence_id": 1}
+{"abstract_id": "24300595", "label": "methods", "text": "Thirty-three obese sedentary women ( age = @ @ years ; body mass index = @ @ kg/m ( @ ) ; systolic BP ( SBP ) = @ @ mm Hg ) were randomized to control carbohydrate ( n = @ ) , whey ( n = @ ) , and casein ( n = @ ) supplementation for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24300595", "label": "methods", "text": "All participants performed moderate-intensity CET @ days/week .", "sentence_id": 3}
+{"abstract_id": "24300595", "label": "methods", "text": "Brachial and aortic SBP , augmentation index adjusted for @ beats/minute ( AIx@@ ) , arterial stiffness ( brachial-ankle pulse wave velocity ( baPWV ) ) , and @-RM were measured before and after the interventions .", "sentence_id": 4}
+{"abstract_id": "24300595", "label": "results", "text": "There were significant ( P < @ ) time-by-group interactions for brachial SBP ( bSBP ) , aortic SBP ( aSBP ) , AIx@@, and baPWV .", "sentence_id": 5}
+{"abstract_id": "24300595", "label": "results", "text": "Whey and casein supplementation significantly ( P < @ ) decreased bSBP ( approximately @mm Hg for both ) , aSBP ( approximately @ mm Hg and approximately @mm Hg , respectively ) , AIx@@ ( approximately @ % and approximately @ % , respectively ) and baPWV ( approximately @ cm/s and approximately @ cm/s , respectively ) compared with no changes in the control group .", "sentence_id": 6}
+{"abstract_id": "24300595", "label": "results", "text": "Upper - ( approximately @ % ) and lower-body @-RM ( approximately @ % ) increased similarly in all groups .", "sentence_id": 7}
+{"abstract_id": "24300595", "label": "results", "text": "Changes in arterial function and @-RM were not correlated .", "sentence_id": 8}
+{"abstract_id": "24300595", "label": "conclusions", "text": "Milk protein supplementation with CET reduced SBP , wave reflection , and arterial stiffness in young obese women with prehypertension and hypertension .", "sentence_id": 9}
+{"abstract_id": "24300595", "label": "conclusions", "text": "Because CET did not affect arterial function , milk proteins may have an antihypertensive effect by improving arterial function , as shown by reduced AIx@@ and baPWV .", "sentence_id": 10}
+{"abstract_id": "24300595", "label": "conclusions", "text": "Muscle strength improvements after CET did not affect BP and arterial function .", "sentence_id": 11}
+{"abstract_id": "24808482", "label": "background", "text": "Management of moderate acute malnutrition ( MAM ) is , currently , focused on food supplementation approaches .", "sentence_id": 0}
+{"abstract_id": "24808482", "label": "background", "text": "However , the sustainability of these strategies remains weak in low - and middle-income countries .", "sentence_id": 1}
+{"abstract_id": "24808482", "label": "background", "text": "In food-secure settings , an educational/behavioral intervention could be an alternative for improving MAM management .", "sentence_id": 2}
+{"abstract_id": "24808482", "label": "objective", "text": "This study compared the effectiveness of weekly context-appropriate child-centered counseling ( CCC ) , with an improved corn-soy blend -LSB- corn-soy blend with added micronutrients ( CSB + + ) -RSB- or a locally produced ready-to-use supplementary food ( RUSF ) , in treating MAM through first-line rural health services .", "sentence_id": 3}
+{"abstract_id": "24808482", "label": "methods", "text": "We used a cluster randomized controlled trial design with @ arms , involving @ rural health centers ( @ by arm ) and children aged @-@ mo with uncomplicated MAM .", "sentence_id": 4}
+{"abstract_id": "24808482", "label": "methods", "text": "In the first arm ( CCC ) , trained health workers provided weekly personalized counseling to caretakers .", "sentence_id": 5}
+{"abstract_id": "24808482", "label": "methods", "text": "In the @ other arms , children received weekly either @ g CSB + + or @ g locally produced soy-based RUSF .", "sentence_id": 6}
+{"abstract_id": "24808482", "label": "methods", "text": "Both food supplements provided @ kcal/d .", "sentence_id": 7}
+{"abstract_id": "24808482", "label": "results", "text": "The recovery rate after @ mo of treatment was significantly lower with CCC ( @ % ) than with CSB + + ( @ % ) and RUSF ( @ % ) ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24808482", "label": "results", "text": "Mothers ' attendance at health facilities was also substantially lower in the CCC arm ( P < @ ) ; this arm had a high defaulter rate ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24808482", "label": "results", "text": "When the analysis was adjusted for attendance , we did not find a significant difference between the @ arms , with incidence rate ratios of @ ( @ % CI : @ , @ ) and @ ( @ % CI : @ , @ ) for the CSB + + and RUSF arms , respectively , compared with the CCC arm .", "sentence_id": 10}
+{"abstract_id": "24808482", "label": "conclusions", "text": "Whereas supplement-based treatment of MAM was found to be more effective than the provision of CCC , we hypothesize that appropriate and specific nutrition counseling centered on children 's needs , through primary health facilities , might be an alternative strategy for MAM treatment in rural food-secure areas , provided that attendance at counseling sessions by the caregiver is ensured .", "sentence_id": 11}
+{"abstract_id": "24808482", "label": "conclusions", "text": "This trial was registered at clinicaltrials.gov as NCT@ .", "sentence_id": 12}
+{"abstract_id": "25504506", "label": "objective", "text": "To evaluate the efficacy and safety of arsenic trioxide transarterial chemoembolization and intravenous administration in unresectable hepatocellular carcinoma with lung metastasis .", "sentence_id": 0}
+{"abstract_id": "25504506", "label": "methods", "text": "A single-blind , two-parallel group , randomized trial was conducted at three medical centers ( Guangzhou , China ) , including patients with both biopsy-confirmed hepatocellular carcinoma and lung metastasis .", "sentence_id": 1}
+{"abstract_id": "25504506", "label": "methods", "text": "The experimental group received arsenic trioxide transarterial chemoembolization and intravenous administration of arsenic trioxide , while the control group only received arsenic trioxide transarterial chemoembolization .", "sentence_id": 2}
+{"abstract_id": "25504506", "label": "methods", "text": "We compared overall survival ( OS ) , time to progression ( TTP ) , disease control rate ( DCR ) , and objective response rate ( ORR ) between the groups .", "sentence_id": 3}
+{"abstract_id": "25504506", "label": "results", "text": "Between April @ and June @ , @ patients received the allocated intervention , @ of whom were in the experimental group and @ of whom were in the control group .", "sentence_id": 4}
+{"abstract_id": "25504506", "label": "results", "text": "No patient was lost to follow-up .", "sentence_id": 5}
+{"abstract_id": "25504506", "label": "results", "text": "The median OS was @ ( @ % CI = @-@ @ ) months in the experimental group and @ ( @ % CI = @-@ @ ) months in the control group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25504506", "label": "results", "text": "The median TTP was @ ( @ % CI = @-@ @ ) months in the experimental group and @ ( @ % CI = @-@ @ ) months in the control group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25504506", "label": "results", "text": "In the experimental group , the DCR was @ % and the ORR was @ % , while in the control group , the DCR was @ % and the ORR was @ % .", "sentence_id": 8}
+{"abstract_id": "25504506", "label": "results", "text": "DCR and ORR differed significantly between the two groups ( P < @ and P = @ , respectively ) .", "sentence_id": 9}
+{"abstract_id": "25504506", "label": "conclusions", "text": "Arsenic trioxide transarterial chemoembolization and intravenous administration were safe and effective in unresectable hepatocellular carcinoma with lung metastasis .", "sentence_id": 10}
+{"abstract_id": "25604219", "label": "objective", "text": "To evaluate the efficacy and safety of dexmedetomidine for post-operative elder patients on mechanical ventilation ( MV ) .", "sentence_id": 0}
+{"abstract_id": "25604219", "label": "methods", "text": "For this randomized controlled trial , @ cases of post-operative patients on MV were enrolled and assigned into either dexmedetomidine group ( n = @ ) or propofol group ( n = @ ) for sedation .", "sentence_id": 1}
+{"abstract_id": "25604219", "label": "methods", "text": "And propofol was used for rescue .", "sentence_id": 2}
+{"abstract_id": "25604219", "label": "methods", "text": "The dose of sedation was regulated by Ramsay score for maintaining a sedative score of @-@ .", "sentence_id": 3}
+{"abstract_id": "25604219", "label": "methods", "text": "In both groups , fentanyl was provided intravenously continually for analgesia .", "sentence_id": 4}
+{"abstract_id": "25604219", "label": "methods", "text": "The amount of fentanyl was adjusted according to the numerical rating scale ( NRS ) score for maintaining an analgesic score of @-@ .", "sentence_id": 5}
+{"abstract_id": "25604219", "label": "methods", "text": "The average Ramsay score , the frequency of propofol , the highest score of NRS , the total dosage of fentanyl and recovery time were compared .", "sentence_id": 6}
+{"abstract_id": "25604219", "label": "methods", "text": "Additional outcomes included duration of mechanical ventilation and intensive care unit ( ICU ) length .", "sentence_id": 7}
+{"abstract_id": "25604219", "label": "methods", "text": "And the incidence of delirium and cardiovascular adverse events were compared for two groups .", "sentence_id": 8}
+{"abstract_id": "25604219", "label": "results", "text": "No significant inter-group difference existed in the effectiveness of sedation .", "sentence_id": 9}
+{"abstract_id": "25604219", "label": "results", "text": "Compare with propofol group , the highest score of NRS decreased ( @ @ vs @ @ , P < @ ) , the total dosage of fentanyl significantly decreased ( @ @ vs @ @ g , P < @ ) and recovery time became significantly shortened ( @ @ h vs @ @ h , P < @ ) in dexmedetomidine group .", "sentence_id": 10}
+{"abstract_id": "25604219", "label": "results", "text": "Median duration of mechanical ventilation in dexmedetomidine group ( @ h , @ % CI : @-@ @ h ) was significantly shorter than that in propofol group ( @ h , @ % CI : @-@ @ h ) ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25604219", "label": "results", "text": "No inter-group differences existed in the ICU length of stay and the incidence of delirium .", "sentence_id": 12}
+{"abstract_id": "25604219", "label": "results", "text": "Two cases in dexmedetomidine group developed bradycardia while hypotension occurred in two cases of propofol group .", "sentence_id": 13}
+{"abstract_id": "25604219", "label": "conclusions", "text": "Sedative effects of dexmedetomidine are safe and effective for post-operative elder patients on MV .", "sentence_id": 14}
+{"abstract_id": "25604219", "label": "conclusions", "text": "And it offers a better efficacy of analgesia and shorter durations of MV and recovery time .", "sentence_id": 15}
+{"abstract_id": "25604219", "label": "conclusions", "text": "But dexmedetomidine had no significant influence on the ICU length of stay or the incidence of delirium .", "sentence_id": 16}
+{"abstract_id": "25327884", "label": "objective", "text": "Similarly to a wrestling match , upper-body intermittent sprint performance ( UBISP ) test elicits severe acidosis .", "sentence_id": 0}
+{"abstract_id": "25327884", "label": "objective", "text": "This study aimed to determine whether sodium citrate ( CIT ) ingestion would help to better maintain peak power ( PP ) and mean power ( MP ) output across four consecutive UBISP tests simulating wrestling matches of a competition-day .", "sentence_id": 1}
+{"abstract_id": "25327884", "label": "methods", "text": "In a double-blind , counterbalanced , crossover manner , @ trained wrestlers ingested either placebo ( PLC ) or CIT ( @ mg kg ( -@ ) ) within a @-h supplementation period .", "sentence_id": 2}
+{"abstract_id": "25327884", "label": "methods", "text": "Thereafter they completed four ( T@-T@ ) @-min UBISP tests interspersed with @-min recovery periods .", "sentence_id": 3}
+{"abstract_id": "25327884", "label": "results", "text": "Compared with PLC , CIT supplementation resulted in a persistent increase ( P < @ ) in blood HCO@ ( - ) concentration and pH : pre-T@ @ % and @ units , post-T@ @ % and @ units , respectively .", "sentence_id": 4}
+{"abstract_id": "25327884", "label": "results", "text": "Post-T@ blood lactate concentration in CIT ( @ @ mmol L ( -@ ) ) was higher ( P = @ ) than that in PLC ( @ @ mmol L ( -@ ) ) .", "sentence_id": 5}
+{"abstract_id": "25327884", "label": "results", "text": "Decrease in plasma volume across the supplementation period and UBISP tests was greater ( P = @ ) in PLC ( -@ @ % ) than in CIT ( -@ @ % ) .", "sentence_id": 6}
+{"abstract_id": "25327884", "label": "results", "text": "There was an overall decrease ( P = @ ) in ratings of perceived exertion in CIT compared with PLC , but no between-trial difference ( P > @ ) in PP or MP in any UBISP test occurred .", "sentence_id": 7}
+{"abstract_id": "25327884", "label": "conclusions", "text": "In trained wrestlers , CIT ingestion induces alkalosis , counteracts reduction in plasma volume , increases post-test blood lactate concentration and reduces perceived exertion , but does not improve PP or MP attained in consecutive UBISP tests simulating four wrestling matches of a competition-day .", "sentence_id": 8}
+{"abstract_id": "24679060", "label": "background", "text": "In short-term randomized trials ( duration , @ to @ years ) , bariatric surgery has been associated with improvement in type @ diabetes mellitus .", "sentence_id": 0}
+{"abstract_id": "24679060", "label": "methods", "text": "We assessed outcomes @ years after the randomization of @ obese patients with uncontrolled type @ diabetes to receive either intensive medical therapy alone or intensive medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy .", "sentence_id": 1}
+{"abstract_id": "24679060", "label": "methods", "text": "The primary end point was a glycated hemoglobin level of @ % or less .", "sentence_id": 2}
+{"abstract_id": "24679060", "label": "results", "text": "The mean ( SD ) age of the patients at baseline was @ years , @ % were women , the mean baseline glycated hemoglobin level was @ % , and the mean baseline body-mass index ( the weight in kilograms divided by the square of the height in meters ) was @ .", "sentence_id": 3}
+{"abstract_id": "24679060", "label": "results", "text": "A total of @ % of the patients completed @ months of follow-up .", "sentence_id": 4}
+{"abstract_id": "24679060", "label": "results", "text": "At @ years , the criterion for the primary end point was met by @ % of the patients in the medical-therapy group , as compared with @ % of those in the gastric-bypass group ( P < @ ) and @ % of those in the sleeve-gastrectomy group ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24679060", "label": "results", "text": "The use of glucose-lowering medications , including insulin , was lower in the surgical groups than in the medical-therapy group .", "sentence_id": 6}
+{"abstract_id": "24679060", "label": "results", "text": "Patients in the surgical groups had greater mean percentage reductions in weight from baseline , with reductions of @ % in the gastric-bypass group and @ % in the sleeve-gastrectomy group , as compared with a reduction of @ % in the medical-therapy group ( P < @ for both comparisons ) .", "sentence_id": 7}
+{"abstract_id": "24679060", "label": "results", "text": "Quality-of-life measures were significantly better in the two surgical groups than in the medical-therapy group .", "sentence_id": 8}
+{"abstract_id": "24679060", "label": "results", "text": "There were no major late surgical complications .", "sentence_id": 9}
+{"abstract_id": "24679060", "label": "conclusions", "text": "Among obese patients with uncontrolled type @ diabetes , @ years of intensive medical therapy plus bariatric surgery resulted in glycemic control in significantly more patients than did medical therapy alone .", "sentence_id": 10}
+{"abstract_id": "24679060", "label": "conclusions", "text": "Analyses of secondary end points , including body weight , use of glucose-lowering medications , and quality of life , also showed favorable results at @ years in the surgical groups , as compared with the group receiving medical therapy alone .", "sentence_id": 11}
+{"abstract_id": "24679060", "label": "conclusions", "text": "( Funded by Ethicon and others ; STAMPEDE ClinicalTrials.gov number , NCT@ . )", "sentence_id": 12}
+{"abstract_id": "24355576", "label": "objective", "text": "The aims of the study were to evaluate the long-term effects of a home-based smoking prevention program ` Smoke-free Kids ' during preadolescence on smoking initiation during adolescence and to test the potential moderating role of parental smoking , socioeconomic status , and asthma .", "sentence_id": 0}
+{"abstract_id": "24355576", "label": "methods", "text": "In @ , @ @-@year old children and their mothers were recruited from @ elementary schools in the Netherlands .", "sentence_id": 1}
+{"abstract_id": "24355576", "label": "methods", "text": "An independent statistician randomly allocated schools to one of the two conditions using a @:@ ratio ( single blind ) : @ children in the intervention and @ in the control condition .", "sentence_id": 2}
+{"abstract_id": "24355576", "label": "methods", "text": "The intervention condition received five activity modules , including a communication sheet for mothers , by mail at four-week intervals and one booster module one year after baseline .", "sentence_id": 3}
+{"abstract_id": "24355576", "label": "methods", "text": "The control condition received a fact-based intervention only .", "sentence_id": 4}
+{"abstract_id": "24355576", "label": "methods", "text": "Intention-to-treat analysis was performed on @ non-smoking children at baseline .", "sentence_id": 5}
+{"abstract_id": "24355576", "label": "results", "text": "In the intervention @ % of the children started smoking compared to @ % in the control condition .", "sentence_id": 6}
+{"abstract_id": "24355576", "label": "results", "text": "This difference was non-significant ( odds ratio = @ , @ % confidence interval = @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24355576", "label": "results", "text": "No moderating effects were found .", "sentence_id": 8}
+{"abstract_id": "24355576", "label": "conclusions", "text": "No effects on smoking initiation after @months were found .", "sentence_id": 9}
+{"abstract_id": "24355576", "label": "conclusions", "text": "Perhaps , the program was implemented with children that were too young .", "sentence_id": 10}
+{"abstract_id": "24355576", "label": "conclusions", "text": "Programs closer to the age of smoking onset should be tested .", "sentence_id": 11}
+{"abstract_id": "24742508", "label": "objective", "text": "To investigate the influence of normal saline nasal irrigation with different temperature on allergic rhinitis ( AR ) and to confirm the appropriate temperature of nasal irrigation .", "sentence_id": 0}
+{"abstract_id": "24742508", "label": "methods", "text": "Sixty patients with AR were randomly divided into @ groups ( according to random number table ) and received @ C , @ C or @ C normal saline nasal irrigation respectively , and @ healthy controls received no treatment .", "sentence_id": 1}
+{"abstract_id": "24742508", "label": "methods", "text": "Visual analogue scale ( VAS ) was used to assess the symptoms among the control group and the various intervention groups and the enzyme linked immunosorbent assay ( ELISA ) was applied to detect the contents of histamine , leukotriene C@ ( LTC@ ) , house dust mite D@ specific IGE ( sIGE ) and eosinophil cationic protein ( ECP ) among the control group and the various intervention groups .", "sentence_id": 2}
+{"abstract_id": "24742508", "label": "methods", "text": "GraphPad Prism @ software was used to analyze the data .", "sentence_id": 3}
+{"abstract_id": "24742508", "label": "results", "text": "There was no statistical difference between @ C normal saline nasal irrigation group and @ C normal saline nasal irrigation group .", "sentence_id": 4}
+{"abstract_id": "24742508", "label": "results", "text": "Pre-intervention and post intervention whether is VAS scores of rhinorrhea , sneezing , nasal obstruction and nasal pruritis or in contents of histamine , LTC@ , sIgE and ECP showed no difference ( all P > @ ) .", "sentence_id": 5}
+{"abstract_id": "24742508", "label": "results", "text": "However , the symptoms of ( sneezing VAS score : @ @ ; nasal obstruction VAS score : @ @ ) .", "sentence_id": 6}
+{"abstract_id": "24742508", "label": "results", "text": "The difference was significant ( t = @ , P < @ ; t = @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24742508", "label": "results", "text": "The contents of histamine -LSB- ( @ @ ) ng/ml -RSB- and LTC@ ( @ @ ng/ml ) were also decreased after intervention of @ C normal saline nasal irrigation -LSB- histamine content : ( @ @ ) ng/ml ; LTC@ content : ( @ @ ) ng/ml -RSB- .", "sentence_id": 8}
+{"abstract_id": "24742508", "label": "results", "text": "The difference was significant ( t = @ , P < @ ; t = @ , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24742508", "label": "results", "text": "Nonetheless , there were no statistical differences in VAS scores of rhinorrhea ( t = @ , P = @ ) and nasal pruritis ( t = @ , P = @ ) and in contents of sIgE ( t = @ , P = @ ) and ECP ( t = @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24742508", "label": "results", "text": "There were statistical differences between the @ C group and the @ C group normal saline nasal irrigation group in symptoms of sneezing ( t = @ , P = @ ) and nasal obstruction ( t = @ , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24742508", "label": "results", "text": "and inflammatory factors of histamine ( t = @ , P = @ ) and LTC@ ( t = @ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24742508", "label": "results", "text": "In symptoms of rhinorrhea and nasal pruritis and local production of sIgE and ECP , there was no statistical difference ( all P > @ ) .", "sentence_id": 13}
+{"abstract_id": "24742508", "label": "conclusions", "text": "@ C normal saline nasal irrigation can improve the symptoms of sneezing and nasal obstruction and can alleviate the local levels of inflammatory factors like histamine and LTC@ in AR patients , and is the appropriate irrigation temperature .", "sentence_id": 14}
+{"abstract_id": "25431430", "label": "background", "text": "Individual-based cognitive-behavioural therapy ( CBT ) is in short supply and expensive .", "sentence_id": 0}
+{"abstract_id": "25431430", "label": "objective", "text": "The aim of this randomised controlled trial ( RCT ) was to compare mindfulness-based group therapy with treatment as usual ( primarily individual-based CBT ) in primary care patients with depressive , anxiety or stress and adjustment disorders .", "sentence_id": 1}
+{"abstract_id": "25431430", "label": "methods", "text": "This @-week RCT ( ClinicalTrials.gov ID : NCT@ ) was conducted during spring @ at @ general practices in Southern Sweden .", "sentence_id": 2}
+{"abstract_id": "25431430", "label": "methods", "text": "Eligible patients ( aged @-@ years ) scored @ on the Patient Health Questionnaire-@ , @ on the Hospital Anxiety and Depression Scale or @-@ on the Montgomery-sberg Depression Rating Scale ( self-rated version ) .", "sentence_id": 3}
+{"abstract_id": "25431430", "label": "methods", "text": "The power calculations were based on non-inferiority .", "sentence_id": 4}
+{"abstract_id": "25431430", "label": "methods", "text": "In total , @ patients were randomised .", "sentence_id": 5}
+{"abstract_id": "25431430", "label": "methods", "text": "Ordinal mixed models were used for the analysis .", "sentence_id": 6}
+{"abstract_id": "25431430", "label": "results", "text": "For all scales and in both groups , the scores decreased significantly .", "sentence_id": 7}
+{"abstract_id": "25431430", "label": "results", "text": "There were no significant differences between the mindfulness and control groups .", "sentence_id": 8}
+{"abstract_id": "25431430", "label": "conclusions", "text": "Mindfulness-based group therapy was non-inferior to treatment as usual for patients with depressive , anxiety or stress and adjustment disorders .", "sentence_id": 9}
+{"abstract_id": "25244977", "label": "objective", "text": "To determine if a new , single-sample device ( ESwab ; Copan Diagnostics , Inc ) can simplify the traditional multi-sample approach to specimen collection in infectious keratitis .", "sentence_id": 0}
+{"abstract_id": "25244977", "label": "methods", "text": "Prospective , diagnostic test evaluation .", "sentence_id": 1}
+{"abstract_id": "25244977", "label": "methods", "text": "In this institutional study , patients with suspected infectious keratitis meeting traditional criteria for diagnostic corneal specimen collection and culture were randomized to the order of first specimen collection method : ESwab or a sample directly plated for growth on chocolate agar .", "sentence_id": 2}
+{"abstract_id": "25244977", "label": "methods", "text": "This was followed by standard samples for blood agar , Gram stain , Sabouraud agar , thioglycolate broth , and brain heart infusion broth in all cases .", "sentence_id": 3}
+{"abstract_id": "25244977", "label": "methods", "text": "The specimens collected using the @ approaches were analyzed separately by the laboratory in a masked fashion .", "sentence_id": 4}
+{"abstract_id": "25244977", "label": "methods", "text": "The main outcome measure was positive growth on cultured media .", "sentence_id": 5}
+{"abstract_id": "25244977", "label": "results", "text": "Eighty-one eyes from @ consecutive patients were sampled .", "sentence_id": 6}
+{"abstract_id": "25244977", "label": "results", "text": "Culture positivity rate for the multi-sample method and ESwab was @ % and @ % , respectively , with a @ % agreement rate .", "sentence_id": 7}
+{"abstract_id": "25244977", "label": "results", "text": "ESwab sensitivity was @ % ( @ % confidence interval -LSB- CI -RSB- : @ % -@ % ) , with a specificity of @ % ( @ % CI : @ % -@ % ) .", "sentence_id": 8}
+{"abstract_id": "25244977", "label": "results", "text": "Positive and negative predictive values of the ESwab were @ % ( @ % CI : @ % -@ % ) and @ % ( @ % CI : @ % -@ % ) , respectively .", "sentence_id": 9}
+{"abstract_id": "25244977", "label": "results", "text": "There was no difference in positive culture reports with respect to the order of specimen collection technique used .", "sentence_id": 10}
+{"abstract_id": "25244977", "label": "conclusions", "text": "The single-sample ESwab method is a more accessible and less cumbersome approach to corneal culturing for ophthalmologists , particularly those in the community setting who do not have access to the full set of traditional culture materials .", "sentence_id": 11}
+{"abstract_id": "25244977", "label": "conclusions", "text": "Culture results using this single-sample approach were comparable to the multi-sample method .", "sentence_id": 12}
+{"abstract_id": "24872261", "label": "background", "text": "The management of open tibia fractures remains controversial despite increase in its incidence .", "sentence_id": 0}
+{"abstract_id": "24872261", "label": "background", "text": "Some surgeons avoid internal fixations for fear of infection while others have demonstrated its superiority .", "sentence_id": 1}
+{"abstract_id": "24872261", "label": "background", "text": "Identifying an optimal management modality is of utmost benefit to our patients .", "sentence_id": 2}
+{"abstract_id": "24872261", "label": "background", "text": "Study objectives were to compare the rate of infection and mean duration to healing in the management of open tibia fractures using unreamed interlocking intramedullary nail and external fixation .", "sentence_id": 3}
+{"abstract_id": "24872261", "label": "methods", "text": "The study was an interventional study comparing two known standard methods of managing open tibia fractures conducted in the orthopaedic and trauma department of a tertiary health institution in South west , Nigeria .", "sentence_id": 4}
+{"abstract_id": "24872261", "label": "methods", "text": "Forty patients who presented with open tibia fractures were allocated alternately into primary interlocking nailing group and external fixation group .", "sentence_id": 5}
+{"abstract_id": "24872261", "label": "methods", "text": "Follow-up was for two years .", "sentence_id": 6}
+{"abstract_id": "24872261", "label": "results", "text": "Incidences of deep wound infection in both groups were @ % ( external fixation ) and @ % ( interlocking nailing ) respectively .", "sentence_id": 7}
+{"abstract_id": "24872261", "label": "results", "text": "The relative risk of developing infection in external fixation group was @ .", "sentence_id": 8}
+{"abstract_id": "24872261", "label": "results", "text": "Mean duration to union was @ weeks and @ weeks in the external fixation and interlocking nailing groups respectively , difference in mean was not statistically significant , ( t = @ , p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24872261", "label": "conclusions", "text": "The risk of wound infection was observed to be higher in this study with the use of external fixation in the management of open tibia fractures compared with unreamed interlocking intramedullary nail .", "sentence_id": 10}
+{"abstract_id": "24534120", "label": "objective", "text": "To determine if concomitant CT-guided biopsy and percutaneous fiducial seed placement in the lung can be performed in a selective patient population without increased complication or decreased success rates compared to either procedure alone .", "sentence_id": 0}
+{"abstract_id": "24534120", "label": "methods", "text": "An IRB approved retrospective analysis of @ consecutive patients that underwent CT-guided placement of fiducial seeds in the lung alone ( N = @ ) , with concomitant core biopsy ( N = @ ) or only core biopsy ( N = @ ) was performed .", "sentence_id": 1}
+{"abstract_id": "24534120", "label": "methods", "text": "Variables compared included : patient demographics , lesion size , depth from pleura , needle size , number of passes through pleura , number and size of core biopsies , number of seeds placed and technical success rates .", "sentence_id": 2}
+{"abstract_id": "24534120", "label": "methods", "text": "Statistical analysis was performed using univariate and multivariate pair-wise comparisons .", "sentence_id": 3}
+{"abstract_id": "24534120", "label": "results", "text": "A pathologic diagnosis of malignancy was confirmed in all cases undergoing seed placement alone and seed placement with concurrent biopsy , and in @ of the biopsy alone lesions .", "sentence_id": 4}
+{"abstract_id": "24534120", "label": "results", "text": "On univariate analysis , major complication rates were similar for all three groups as were lesion size , depth , number of pleural passes , and technical success .", "sentence_id": 5}
+{"abstract_id": "24534120", "label": "results", "text": "Pair-wise comparisons of the remaining variables demonstrated a significant younger age and smaller needle size in the biopsy only group , and less minor complications in the fiducial only group .", "sentence_id": 6}
+{"abstract_id": "24534120", "label": "results", "text": "Overall there were @/@ ( @ % ) minor and @/@ ( @ % ) major complications .", "sentence_id": 7}
+{"abstract_id": "24534120", "label": "results", "text": "All major complications leading to admission consisted of either pneumothorax or hemothorax , while minor complications included asymptomatic stable or resolving pneumothoraces , transient hemoptysis or small hemothoraces .", "sentence_id": 8}
+{"abstract_id": "24534120", "label": "conclusions", "text": "A combined procedure of percutaneous pulmonary core biopsy and stereotactic seed placement can be performed without additional risk of a major complication when compared to performing these separately .", "sentence_id": 9}
+{"abstract_id": "25161823", "label": "background", "text": "The day-to-day causes of stress are called daily hassles .", "sentence_id": 0}
+{"abstract_id": "25161823", "label": "background", "text": "Daily hassles are correlated with ill health .", "sentence_id": 1}
+{"abstract_id": "25161823", "label": "background", "text": "Biofeedback ( BF ) is one of the tools used for acquiring stress-coping skills .", "sentence_id": 2}
+{"abstract_id": "25161823", "label": "background", "text": "However , the anatomical correlates of the effects of BF with long training periods remain unclear .", "sentence_id": 3}
+{"abstract_id": "25161823", "label": "background", "text": "In this study , we aimed to investigate this .", "sentence_id": 4}
+{"abstract_id": "25161823", "label": "methods", "text": "PARTICIPANTS WERE ASSIGNED RANDOMLY TO TWO GROUPS : the intervention group and the control group .", "sentence_id": 5}
+{"abstract_id": "25161823", "label": "methods", "text": "Participants in the intervention group performed a biofeedback training ( BFT ) task ( a combination task for heart rate and cerebral blood flow control ) every day , for about @ min once a day .", "sentence_id": 6}
+{"abstract_id": "25161823", "label": "methods", "text": "The study outcomes included MRI , psychological tests ( e.g. , Positive and Negative Affect Schedule , Center for Epidemiologic Studies Depression Scale , and Brief Job Stress Questionnaire ) , and a stress marker ( salivary cortisol levels ) before ( day @ ) and after ( day @ ) the intervention .", "sentence_id": 7}
+{"abstract_id": "25161823", "label": "results", "text": "We observed significant improvements in the psychological test scores and salivary cortisol levels in the intervention group compared to the control group .", "sentence_id": 8}
+{"abstract_id": "25161823", "label": "results", "text": "Furthermore , voxel-based morphometric analysis revealed that compared to the control group , the intervention group had significantly increased regional gray matter ( GM ) volume in the right lateral orbitofrontal cortex , which is an anatomical cluster that includes mainly the left hippocampus , and the left subgenual anterior cingulate cortex .", "sentence_id": 9}
+{"abstract_id": "25161823", "label": "results", "text": "The GM regions are associated with the stress response , and , in general , these regions seem to be the most sensitive to the detrimental effects of stress .", "sentence_id": 10}
+{"abstract_id": "25161823", "label": "conclusions", "text": "Our findings suggest that our BFT is effective against the GM structures vulnerable to stress .", "sentence_id": 11}
+{"abstract_id": "26122282", "label": "background", "text": "Recent reports have questioned the adequacy of self-report measures of dietary intake as the basis for scientific conclusions regarding the associations of dietary intake and health , and reports have recommended the development and evaluation of better methods for the assessment of dietary intake in free-living individuals .", "sentence_id": 0}
+{"abstract_id": "26122282", "label": "background", "text": "We developed a procedure that used pre - and post-meal digital photographs in combination with dietary recalls ( DP+R ) to assess energy intake during ad libitum eating in a cafeteria setting .", "sentence_id": 1}
+{"abstract_id": "26122282", "label": "objective", "text": "To compare mean daily energy intake of overweight and obese young adults assessed by a DP+R method with mean total daily energy expenditure assessed by doubly labeled water ( TDEE ( DLW ) ) .", "sentence_id": 2}
+{"abstract_id": "26122282", "label": "methods", "text": "Energy intake was assessed using the DP+R method in @ overweight and obese young adults ( age = @ years , body mass index -LSB- BMI ; calculated as kg/m ( @ ) -RSB- = @ , female = @ % ) over @ days of ad libitum eating in a university cafeteria .", "sentence_id": 3}
+{"abstract_id": "26122282", "label": "methods", "text": "Foods consumed outside the cafeteria ( ie , snacks , non-cafeteria meals ) were assessed using multiple-pass recall procedures , using food models and standardized , neutral probing questions .", "sentence_id": 4}
+{"abstract_id": "26122282", "label": "methods", "text": "TDEE ( DLW ) was assessed in all participants over the @-day period .", "sentence_id": 5}
+{"abstract_id": "26122282", "label": "results", "text": "The mean energy intakes estimated by DP+R and TDEE ( DLW ) were not significantly different ( DP+R = @ kcal/d ; TDEE ( DLW ) = @ kcal/d , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26122282", "label": "results", "text": "The DP+R method overestimated TDEE ( DLW ) by @ kcal/d ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "26122282", "label": "conclusions", "text": "Results suggest that the DP+R method provides estimates of energy intake comparable to those obtained by TDEE ( DLW ) .", "sentence_id": 8}
+{"abstract_id": "25468576", "label": "objective", "text": "To investigate the onset and analgesic effect of adding dexmedetomidine to levobupivacaine for caudal block in young children .", "sentence_id": 0}
+{"abstract_id": "25468576", "label": "methods", "text": "Randomized , prospective , double-blind study .", "sentence_id": 1}
+{"abstract_id": "25468576", "label": "methods", "text": "Women and Children Medical Center and university hospital .", "sentence_id": 2}
+{"abstract_id": "25468576", "label": "methods", "text": "Two hundred twelve children , American Society of Anesthesiologists physical status I or II , aged between @ and @ years and weighing between @ and @ kg , who were scheduled for elective inguinal hernia repair or hydrocele .", "sentence_id": 3}
+{"abstract_id": "25468576", "label": "methods", "text": "Children were randomly allocated , using a computer-generated sequence of numbers , into @ of @ groups : caudal @ % levobupivacaine ( Group L ( @ ) ) , caudal @ % levobupivacaine ( Group L ( @ ) ) , or caudal @ % levobupivacaine plus @ g/kg dexmedetomidine ( Group LD ) .", "sentence_id": 4}
+{"abstract_id": "25468576", "label": "results", "text": "The primary end point of the study was the onset time of caudal levobupivacaine in children .", "sentence_id": 5}
+{"abstract_id": "25468576", "label": "results", "text": "The secondary end points of the study were the duration of analgesia and the degree of motor block in children .", "sentence_id": 6}
+{"abstract_id": "25468576", "label": "results", "text": "The @ % and @ % effective onset time ( @ % confidence interval ) values of levobupivacaine were @ minutes ( @-@ @ ) and @ minutes ( @-@ @ ) in Group L ( @ ) , @ minutes ( @-@ @ ) and @ minutes ( @-@ @ ) in Group L ( @ ) , and @ minutes ( @-@ @ ) and @ minutes ( @-@ @ ) in Group LD , respectively .", "sentence_id": 7}
+{"abstract_id": "25468576", "label": "results", "text": "The mean durations of analgesia in these children were @ , @ , and @ hours in Groups L ( @ ) , L ( @ ) , and LD , respectively .", "sentence_id": 8}
+{"abstract_id": "25468576", "label": "results", "text": "There were no significant differences in postoperative residual motor block among the @ groups .", "sentence_id": 9}
+{"abstract_id": "25468576", "label": "conclusions", "text": "Dexmedetomidine added to levobupivacaine does not have a significant effect on the onset time ; however , it prolongs the duration of analgesia during caudal block in children .", "sentence_id": 10}
+{"abstract_id": "25064291", "label": "objective", "text": "This study 's objective was to investigate whether use of an electronic dietary recording system improves nutrition knowledge , eating attitudes and habitual physical activity levels compared to use of a food diary and no self-monitoring .", "sentence_id": 0}
+{"abstract_id": "25064291", "label": "methods", "text": "Sixty adults aged @-@ with a body mass index @ were recruited and randomly assigned to one of three groups : a group using an electronic system ( EG ) , a group using a food diary ( FD ) and a control group using nothing ( CG ) to record food intake .", "sentence_id": 1}
+{"abstract_id": "25064291", "label": "methods", "text": "All participants took part in three @-@ nutrition seminars and completed three questionnaires on general nutrition knowledge , habitual physical activity levels and eating attitudes at the beginning and end of the @-week study .", "sentence_id": 2}
+{"abstract_id": "25064291", "label": "methods", "text": "The pre - and post-test scores for each questionnaire were analysed using a paired sample t-test .", "sentence_id": 3}
+{"abstract_id": "25064291", "label": "results", "text": "Significant improvements in the domain of ` dietary recommendations ' were found in the EG ( p = @ ) and FD groups ( p = @ ) .", "sentence_id": 4}
+{"abstract_id": "25064291", "label": "results", "text": "Great improvements were found in ` sources of nutrients ' , ` choosing everyday foods ' and ` diet-disease relationships ' in EG and FD groups .", "sentence_id": 5}
+{"abstract_id": "25064291", "label": "results", "text": "EG group showed greater improvement in the work index and sport index .", "sentence_id": 6}
+{"abstract_id": "25064291", "label": "conclusions", "text": "An electronic dietary recording system may improve eating and exercise behaviour in a self-monitoring process .", "sentence_id": 7}
+{"abstract_id": "25004917", "label": "objective", "text": "To investigate whether an early rehabilitation intervention initiated during acute admission for exacerbations of chronic respiratory disease reduces the risk of readmission over @ months and ameliorates the negative effects of the episode on physical performance and health status .", "sentence_id": 0}
+{"abstract_id": "25004917", "label": "methods", "text": "Prospective , randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25004917", "label": "methods", "text": "An acute cardiorespiratory unit in a teaching hospital and an acute medical unit in an affiliated teaching district general hospital , United Kingdom .", "sentence_id": 2}
+{"abstract_id": "25004917", "label": "methods", "text": "@ patients aged between @ and @ who within @ hours of admission to hospital with an exacerbation of chronic respiratory disease were randomised to an early rehabilitation intervention ( n = @ ) or to usual care ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25004917", "label": "methods", "text": "The primary outcome was readmission rate at @ months .", "sentence_id": 4}
+{"abstract_id": "25004917", "label": "methods", "text": "Secondary outcomes included number of hospital days , mortality , physical performance , and health status .", "sentence_id": 5}
+{"abstract_id": "25004917", "label": "methods", "text": "The primary analysis was by intention to treat , with prespecified per protocol analysis as a secondary outcome .", "sentence_id": 6}
+{"abstract_id": "25004917", "label": "methods", "text": "Participants in the early rehabilitation group received a six week intervention , started within @ hours of admission .", "sentence_id": 7}
+{"abstract_id": "25004917", "label": "methods", "text": "The intervention comprised prescribed , progressive aerobic , resistance , and neuromuscular electrical stimulation training .", "sentence_id": 8}
+{"abstract_id": "25004917", "label": "methods", "text": "Patients also received a self management and education package .", "sentence_id": 9}
+{"abstract_id": "25004917", "label": "results", "text": "Of the @ participants , @ ( @ % ) had a primary diagnosis of chronic obstructive pulmonary disease .", "sentence_id": 10}
+{"abstract_id": "25004917", "label": "results", "text": "@ ( @ % ) were readmitted at least once in the following year ( @ % in the intervention group and @ % in the control group ) .", "sentence_id": 11}
+{"abstract_id": "25004917", "label": "results", "text": "No significant difference between groups was found ( hazard ratio @ , @ % confidence interval @ to @ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25004917", "label": "results", "text": "An increase in mortality was seen in the intervention group at one year ( odds ratio @ , @ % confidence interval @ to @ , P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25004917", "label": "results", "text": "Significant recovery in physical performance and health status was seen after discharge in both groups , with no significant difference between groups at one year .", "sentence_id": 14}
+{"abstract_id": "25004917", "label": "conclusions", "text": "Early rehabilitation during hospital admission for chronic respiratory disease did not reduce the risk of subsequent readmission or enhance recovery of physical function following the event over @ months .", "sentence_id": 15}
+{"abstract_id": "25004917", "label": "conclusions", "text": "Mortality at @ months was higher in the intervention group .", "sentence_id": 16}
+{"abstract_id": "25004917", "label": "conclusions", "text": "The results suggest that beyond current standard physiotherapy practice , progressive exercise rehabilitation should not be started during the early stages of the acute illness.Trial registration Current Controlled Trials ISRCTN@ .", "sentence_id": 17}
+{"abstract_id": "25624387", "label": "background", "text": "Pediatric sleep disordered breathing is often caused by hypertrophy of the tonsils and is commonly managed by tonsillectomy .", "sentence_id": 0}
+{"abstract_id": "25624387", "label": "background", "text": "There is controversy regarding which postsurgical analgesic agents are safe and efficacious .", "sentence_id": 1}
+{"abstract_id": "25624387", "label": "methods", "text": "This prospective randomized clinical trial recruited children who had sleep disordered breathing who were scheduled for tonsillectomy + / - adenoid removal .", "sentence_id": 2}
+{"abstract_id": "25624387", "label": "methods", "text": "Parents were provided with a pulse oximeter to measure oxygen saturation and apnea events the night before and the night after surgery .", "sentence_id": 3}
+{"abstract_id": "25624387", "label": "methods", "text": "Children were randomized to receive acetaminophen with either @-@ @ mg/kg oral morphine or @ mg/kg of oral ibuprofen .", "sentence_id": 4}
+{"abstract_id": "25624387", "label": "methods", "text": "The Objective Pain Scale and Faces Scale were used to assess effectiveness on postoperative day @ and day @ .", "sentence_id": 5}
+{"abstract_id": "25624387", "label": "methods", "text": "The primary endpoint was changes in respiratory parameters during sleep .", "sentence_id": 6}
+{"abstract_id": "25624387", "label": "results", "text": "A total of @ children aged @ to @ years were randomized .", "sentence_id": 7}
+{"abstract_id": "25624387", "label": "results", "text": "On the first postoperative night , with respect to oxygen desaturations , @ % of children did not show improvement in the morphine group , whereas @ % of ibuprofen patients did show improvement ( @ % vs @ % ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25624387", "label": "results", "text": "The number of desaturation events increased substantially in the morphine group , with an average increase of @ @ desaturation events per hour ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25624387", "label": "results", "text": "There were no differences seen in analgesic effectiveness , tonsillar bleeding , or adverse drug reactions .", "sentence_id": 10}
+{"abstract_id": "25624387", "label": "conclusions", "text": "Ibuprofen in combination with acetaminophen provides safe and effective analgesia in children undergoing tonsillectomy .", "sentence_id": 11}
+{"abstract_id": "25624387", "label": "conclusions", "text": "Post-tonsillectomy morphine use should be limited , as it may be unsafe in certain children .", "sentence_id": 12}
+{"abstract_id": "24531203", "label": "objective", "text": "We tested the hypothesis that higher-intensity interval training ( HIIT ) could be deployed into a standard cardiac rehabilitation ( CR ) setting and would result in a greater increase in cardiorespiratory fitness ( ie , peak oxygen uptake , ( ) VO ) versus moderate-intensity continuous training ( MCT ) .", "sentence_id": 0}
+{"abstract_id": "24531203", "label": "methods", "text": "Thirty-nine patients participating in a standard phase @ CR program were randomized to HIIT or MCT ; @ patients and @ patients in the HIIT and MCT groups , respectively , completed CR and baseline and followup cardiopulmonary exercise testing .", "sentence_id": 1}
+{"abstract_id": "24531203", "label": "results", "text": "No patients in either study group experienced an event that required hospitalization during or within @ hours after exercise .", "sentence_id": 2}
+{"abstract_id": "24531203", "label": "results", "text": "The changes in resting heart rate and blood pressure at followup testing were similar for both HIIT and MCT .", "sentence_id": 3}
+{"abstract_id": "24531203", "label": "results", "text": "( ) VO at ventilatory-derived anaerobic threshold increased more ( P < @ ) with HIIT ( @ @ mLkgmin ) versus MCT ( @ @ mLkgmin ) .", "sentence_id": 4}
+{"abstract_id": "24531203", "label": "results", "text": "During followup testing , submaximal heart rate at the end of stage @ of the exercise test was significantly lower within both the HIIT and MCT groups , with no difference noted between groups .", "sentence_id": 5}
+{"abstract_id": "24531203", "label": "results", "text": "Peak ( ) VO improved more after CR in patients in HIIT versus MCT ( @ @ mLkgmin vs @ @ mLkgmin ; P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24531203", "label": "conclusions", "text": "Among patients with stable coronary heart disease on evidence-based therapy , HIIT was successfully integrated into a standard CR setting and , when compared to MCT , resulted in greater improvement in peak exercise capacity and submaximal endurance .", "sentence_id": 7}
+{"abstract_id": "24229362", "label": "background", "text": "During cancer treatment children have reduced contact with their social network of friends , and have limited participation in education , sports , and leisure activities .", "sentence_id": 0}
+{"abstract_id": "24229362", "label": "background", "text": "During and following cancer treatment , children describe school related problems , reduced physical fitness , and problems related to interaction with peers .", "sentence_id": 1}
+{"abstract_id": "24229362", "label": "methods", "text": "The RESPECT study is a nationwide population-based prospective , controlled , mixed-methods intervention study looking at children aged @-@ years newly diagnosed with cancer in eastern Denmark ( n = @ ) and a matched control group in western Denmark ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24229362", "label": "methods", "text": "RESPECT includes Danish-speaking children diagnosed with cancer and treated at pediatric oncology units in Denmark .", "sentence_id": 3}
+{"abstract_id": "24229362", "label": "methods", "text": "Primary endpoints are the level of educational achievement one year after the cessation of first-line cancer therapy , and the value of VO@max one year after the cessation of first-line cancer therapy .", "sentence_id": 4}
+{"abstract_id": "24229362", "label": "methods", "text": "Secondary endpoints are quality of life measured by validated questionnaires and interviews , and physical performance .", "sentence_id": 5}
+{"abstract_id": "24229362", "label": "methods", "text": "RESPECT includes a multimodal intervention program , including ambassador-facilitated educational , physical , and social interventions .", "sentence_id": 6}
+{"abstract_id": "24229362", "label": "methods", "text": "The educational intervention includes an educational program aimed at the child with cancer , the child 's schoolteachers and classmates , and the child 's parents .", "sentence_id": 7}
+{"abstract_id": "24229362", "label": "methods", "text": "Children with cancer will each have two ambassadors assigned from their class .", "sentence_id": 8}
+{"abstract_id": "24229362", "label": "methods", "text": "The ambassadors visit the child with cancer at the hospital at alternating @-week intervals and participate in the intervention program .", "sentence_id": 9}
+{"abstract_id": "24229362", "label": "methods", "text": "The physical and social intervention examines the effect of early , structured , individualized , and continuous physical activity from diagnosis throughout the treatment period .", "sentence_id": 10}
+{"abstract_id": "24229362", "label": "methods", "text": "The patients are tested at diagnosis , at @ and @ months after diagnosis , and one year after the cessation of treatment .", "sentence_id": 11}
+{"abstract_id": "24229362", "label": "methods", "text": "The study is powered to quantify the impact of the combined educational , physical , and social intervention programs .", "sentence_id": 12}
+{"abstract_id": "24229362", "label": "conclusions", "text": "RESPECT is the first population-based study to examine the effect of early rehabilitation for children with cancer , and to use healthy classmates as ambassadors to facilitate the normalization of social life in the hospital .", "sentence_id": 13}
+{"abstract_id": "24229362", "label": "conclusions", "text": "For children with cancer , RESPECT contributes to expanding knowledge on rehabilitation that can also facilitate rehabilitation of other children undergoing hospitalization for long-term illness .", "sentence_id": 14}
+{"abstract_id": "24861503", "label": "background", "text": "Statin therapy is a cornerstone therapy for secondary prevention after acute coronary syndrome ( ACS ) .", "sentence_id": 0}
+{"abstract_id": "24861503", "label": "background", "text": "However , the use of these drugs can be limited by side effects , mainly muscular pain .", "sentence_id": 1}
+{"abstract_id": "24861503", "label": "background", "text": "Ezetimibe is a newer lipid-lowering agent , with fewer side effects .", "sentence_id": 2}
+{"abstract_id": "24861503", "label": "objective", "text": "The present study was designed to compare a commercially available association of ezetimibe and simvastatin ( E-S ) to high dose Rosuvastatin on cholesterol and muscular enzyme levels and occurrence of muscular pain .", "sentence_id": 3}
+{"abstract_id": "24861503", "label": "methods", "text": "All consecutive ACS statin-nave patients with LDL cholesterol ( LDL-C ) > @mg/dL randomly received either high dose statin ( Rosuvastatin @mg ) or E-S @/@-mg .", "sentence_id": 4}
+{"abstract_id": "24861503", "label": "methods", "text": "All patients had one-month follow-up with biological testing and clinical examination .", "sentence_id": 5}
+{"abstract_id": "24861503", "label": "methods", "text": "We compared the two groups on the biological efficiency and incidence of muscular pain .", "sentence_id": 6}
+{"abstract_id": "24861503", "label": "results", "text": "One hundred and twenty-eight patients were randomized ; @ received E-S and @ Rosuvastatin .", "sentence_id": 7}
+{"abstract_id": "24861503", "label": "results", "text": "In the two groups , the lowering of LDL-C level ( = @ % ) at one month was significant ( P < @ ) without any difference in the rate of lowering on LDL-C or HDL-C suggesting that E-S is as effective as high dose Rosuvastatin ( P = @ and P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24861503", "label": "results", "text": "The rate of patients reaching the objective of LDL-C < @mg/dL ( @ % ) and LDL-C < @mg/dL ( @ % ) was not different in the two clusters ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24861503", "label": "results", "text": "Incidence of muscular pain was @ % higher in patients treated with Rosuvastatin ( P = @ ) without any difference on CPK level ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24861503", "label": "conclusions", "text": "Using an association of E-S in an effective alternative strategy to high dose Rosuvastatin with a lower incidence of muscular pain , which might impact adherence to medication after ACS .", "sentence_id": 11}
+{"abstract_id": "24297633", "label": "objective", "text": "The aim of this study was to compare the efficacy of the treatment of patients with spontaneous pneumothorax with air leak ( AL ) using two different chest drainage systems .", "sentence_id": 0}
+{"abstract_id": "24297633", "label": "methods", "text": "Patients were randomized into two groups : group A included @ patients ( @ males and @ females , mean age @ y , range @-@ y ) in which digital drainage system was used , group B with @ patients ( @ males and @ females , mean age @ y , range @-@ y ) in which traditional suction drainage system was applied.The following variables were evaluated : intensity of AL , duration of the chest tube drainage , delay in surgery , length of stay , and the overall hospitalization costs .", "sentence_id": 1}
+{"abstract_id": "24297633", "label": "results", "text": "In group A the mean drainage duration was @ hours , the hospitalization time was about @ days , and the cost of hospitalization was @,@ .", "sentence_id": 2}
+{"abstract_id": "24297633", "label": "results", "text": "In group B the mean drainage duration was @ hours , the hospitalization time was @ days , and the hospitalization cost was @,@ .", "sentence_id": 3}
+{"abstract_id": "24297633", "label": "conclusions", "text": "The digital drainage system applied in the treatment of AL in patients with pneumothoraces reduced the duration of the drainage , the length of hospital stay , and overall hospitalization costs .", "sentence_id": 4}
+{"abstract_id": "24607046", "label": "background", "text": "MP@-@ is a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate ( FP ) in an advanced delivery system for the treatment of seasonal allergic rhinitis .", "sentence_id": 0}
+{"abstract_id": "24607046", "label": "objective", "text": "The objective of this study was to evaluate the long-term safety of MP@-@ in subjects with chronic allergic ( perennial ) or nonallergic ( vasomotor ) rhinitis .", "sentence_id": 1}
+{"abstract_id": "24607046", "label": "methods", "text": "This was a @-year , randomized , open-label , active-controlled , parallel-group study in subjects with chronic allergic or nonallergic rhinitis .", "sentence_id": 2}
+{"abstract_id": "24607046", "label": "methods", "text": "A total of @ subjects were randomized in a @:@ ratio to ( @ ) MP@-@ , one spray per nostril twice daily ( total daily doses of azelastine hydrochloride and FP were @ mcg and @ mcg , respectively ) ; or ( @ ) FP , @ sprays per nostril once daily ( total daily dose @ mcg ) .", "sentence_id": 3}
+{"abstract_id": "24607046", "label": "methods", "text": "Safety and tolerability assessments were made at months @ , @ , @ , @ , and @ .", "sentence_id": 4}
+{"abstract_id": "24607046", "label": "results", "text": "The incidence of treatment-related adverse events was low with both MP@-@ ( @ % ) and FP ( @ % ) , with no evidence of late-occurring adverse events .", "sentence_id": 5}
+{"abstract_id": "24607046", "label": "results", "text": "Nasal examinations showed no evidence of nasal mucosal ulcerations or septal perforations with MP@-@ , and the overall incidence of adverse findings was reduced as the study progressed .", "sentence_id": 6}
+{"abstract_id": "24607046", "label": "results", "text": "There were no unusual or unexpected ocular examination findings and no clinically important laboratory findings or clinically important differences between groups in fasting AM serum cortisol levels after @ months of treatment .", "sentence_id": 7}
+{"abstract_id": "24607046", "label": "conclusions", "text": "MP@-@ was well tolerated .", "sentence_id": 8}
+{"abstract_id": "24607046", "label": "conclusions", "text": "There were no safety findings that would preclude the long-term use of MP@-@ in the treatment of allergic rhinitis .", "sentence_id": 9}
+{"abstract_id": "25728587", "label": "background", "text": "As treatment goals in Crohn 's disease ( CD ) evolve , targets now include clinical remission ( CR ) , mucosal healing ( MH ) and biological remission -LSB- C-reactive protein normalisation ( CRPnorm ) -RSB- .", "sentence_id": 0}
+{"abstract_id": "25728587", "label": "objective", "text": "To evaluate the association of baseline factors and treatment with the achievement of different composite remission parameters at week @ .", "sentence_id": 1}
+{"abstract_id": "25728587", "label": "methods", "text": "This post hoc analysis of the SONIC trial evaluated different composite remission measures at week @ in a subgroup of patients with Crohn 's disease activity index ( CDAI ) scores , CRP , and endoscopic data available at baseline and week @ ( N = @ ) .", "sentence_id": 2}
+{"abstract_id": "25728587", "label": "methods", "text": "Assessed composite remission measures were : CR ( CDAI < @ ) and MH ( absence of any mucosal ulcerations ) , previously referred to as ` deep remission ; ' and alternative composite endpoints : CR+CRP norm ( CRP < @ mg/dL ) ; CRPnorm + MH ; and CR+CRP norm + MH .", "sentence_id": 3}
+{"abstract_id": "25728587", "label": "results", "text": "Among analysed patients , @/@ ( @ % ) achieved CR and @/@ ( @ % ) achieved MH at week @ .", "sentence_id": 4}
+{"abstract_id": "25728587", "label": "results", "text": "All composite outcomes were significantly greater ( Bonferroni significance level , P@ @ ) with combination therapy ( i.e. infliximab and azathioprine ; @-@ @ % ) vs. azathioprine monotherapy ( @-@ @ % ; p @ for all comparisons ) .", "sentence_id": 5}
+{"abstract_id": "25728587", "label": "results", "text": "Composite remission rates including MH were significantly greater with combination therapy ( @-@ @ % ) vs. infliximab ( @-@ @ % ; P@ @ for all comparisons except CRPnorm + MH , P = @ ) and vs. azathioprine monotherapy ( @-@ @ % ; P@ @ for all comparisons ) .", "sentence_id": 6}
+{"abstract_id": "25728587", "label": "results", "text": "Median serum trough infliximab concentrations among patients who achieved MH or CR+MH were greater when compared with those among patients who did not achieve MH ( P = @ ) or CR+MH ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25728587", "label": "results", "text": "Among the subgroup of patients with early Crohn 's disease , MH alone or in combination with composite remission criteria significantly improved clinical outcomes of patients who received combination therapy .", "sentence_id": 8}
+{"abstract_id": "25728587", "label": "conclusions", "text": "Combination therapy was more effective in achieving various composite remission measures vs. azathioprine or infliximab monotherapy .", "sentence_id": 9}
+{"abstract_id": "25728587", "label": "conclusions", "text": "These data illustrate that ` deep remission ' is achievable with combination therapy in a high percentage of patients with early Crohn 's disease .", "sentence_id": 10}
+{"abstract_id": "25728587", "label": "conclusions", "text": "ClinicalTrials.gov number : NCT@ .", "sentence_id": 11}
+{"abstract_id": "24273179", "label": "background", "text": "We compared the immunogenicity and reactogenicity of Cervarix or Gardasil human papillomavirus ( HPV ) vaccines in adults infected with the human immunodeficiency virus ( HIV ) .", "sentence_id": 0}
+{"abstract_id": "24273179", "label": "methods", "text": "This was a double-blind , controlled trial randomizing HIV-positive adults to receive @ doses of Cervarix or Gardasil at @ , @ , and @ months .", "sentence_id": 1}
+{"abstract_id": "24273179", "label": "methods", "text": "Immunogenicity was evaluated for up to @ months .", "sentence_id": 2}
+{"abstract_id": "24273179", "label": "methods", "text": "Neutralizing anti-HPV-@ / @ antibodies were measured by pseudovirion-based neutralization assay .", "sentence_id": 3}
+{"abstract_id": "24273179", "label": "methods", "text": "Laboratory tests and diary cards were used for safety assessment .", "sentence_id": 4}
+{"abstract_id": "24273179", "label": "methods", "text": "The HPV-DNA status of the participants was determined before and after immunization .", "sentence_id": 5}
+{"abstract_id": "24273179", "label": "results", "text": "Ninety-two participants were included in the study .", "sentence_id": 6}
+{"abstract_id": "24273179", "label": "results", "text": "Anti-HPV-@ antibody titers were higher in the Cervarix group compared with the Gardasil group at @ and @ months .", "sentence_id": 7}
+{"abstract_id": "24273179", "label": "results", "text": "No significant differences in anti-HPV-@ antibody titers were found among vaccine groups .", "sentence_id": 8}
+{"abstract_id": "24273179", "label": "results", "text": "Among Cervarix vaccinees , women had higher anti-HPV-@ / @ antibody titers compared to men .", "sentence_id": 9}
+{"abstract_id": "24273179", "label": "results", "text": "No sex-specific differences in antibody titers were found in the Gardasil group .", "sentence_id": 10}
+{"abstract_id": "24273179", "label": "results", "text": "Mild injection site reactions were more common in the Cervarix group than in the Gardasil group ( @ % vs @ % ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24273179", "label": "results", "text": "No serious adverse events occurred .", "sentence_id": 12}
+{"abstract_id": "24273179", "label": "conclusions", "text": "Both vaccines were immunogenic and well tolerated .", "sentence_id": 13}
+{"abstract_id": "24273179", "label": "conclusions", "text": "Compared with Gardasil , Cervarix induced superior vaccine responses among HIV-infected women , whereas in HIV-infected men the difference in immunogenicity was less pronounced .", "sentence_id": 14}
+{"abstract_id": "25457902", "label": "objective", "text": "This study sought to evaluate the effect of macitentan on hospitalization of patients with symptomatic pulmonary arterial hypertension ( PAH ) .", "sentence_id": 0}
+{"abstract_id": "25457902", "label": "background", "text": "PAH is a progressive , life-threatening disease often requiring hospitalization .", "sentence_id": 1}
+{"abstract_id": "25457902", "label": "methods", "text": "In the multicenter , double-blind , randomized , event-driven , phase III SERAPHIN ( Study with an Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome ) trial , patients with symptomatic PAH were randomized ( @:@:@ ) to receive placebo or @ mg or @ mg of macitentan .", "sentence_id": 2}
+{"abstract_id": "25457902", "label": "methods", "text": "Effects of macitentan on the risk , rate , and number of hospital days for all-cause and PAH-related hospitalizations were compared with those for placebo .", "sentence_id": 3}
+{"abstract_id": "25457902", "label": "methods", "text": "Risk and causes of hospitalizations unrelated to PAH were investigated .", "sentence_id": 4}
+{"abstract_id": "25457902", "label": "results", "text": "Of @ randomized patients , @ received placebo , @ received @ mg of macitentan , and @ received @ mg of macitentan ; the overall median duration of treatment was @ weeks .", "sentence_id": 5}
+{"abstract_id": "25457902", "label": "results", "text": "Risk of all-cause hospitalization was reduced by @ % ( p = @ ) and @ % ( p = @ ) in the macitentan @-mg and @-mg arm , respectively .", "sentence_id": 6}
+{"abstract_id": "25457902", "label": "results", "text": "Rates of all-cause hospitalizations and numbers of hospital days were reduced by @ % ( p = @ ) and @ % ( p = @ ) , respectively , with @ mg of macitentan and by @ % ( p = @ ) and @ % ( p = @ ) , respectively , with @ mg of macitentan .", "sentence_id": 7}
+{"abstract_id": "25457902", "label": "results", "text": "Risk of PAH-related hospitalizations were reduced by @ % ( p = @ ) and @ % ( p < @ ) in the macitentan @-mg and @-mg arms , respectively .", "sentence_id": 8}
+{"abstract_id": "25457902", "label": "results", "text": "Rate of PAH-related hospitalizations and numbers of hospital days were reduced by @ % ( p = @ ) and @ % ( p = @ ) , respectively , with @ mg of macitentan , and reduced by @ % ( p < @ ) and @ % ( p = @ ) , respectively , with @ mg of macitentan .", "sentence_id": 9}
+{"abstract_id": "25457902", "label": "results", "text": "Risk of non-PAH-related hospitalization was similar between treatment arms .", "sentence_id": 10}
+{"abstract_id": "25457902", "label": "conclusions", "text": "Macitentan @ mg significantly reduced the risk and rate of all-cause hospitalization , which was driven by reductions in the risk and rate of PAH-related hospitalization .", "sentence_id": 11}
+{"abstract_id": "25457902", "label": "conclusions", "text": "( Study of Macitentan -LSB- ACT-@ -RSB- on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension ; NCT@ ) .", "sentence_id": 12}
+{"abstract_id": "25812845", "label": "background", "text": "Sequential compression devices ( SCDs ) reduce deep venous thrombosis in postsurgical patients , but the use is hindered by poor compliance .", "sentence_id": 0}
+{"abstract_id": "25812845", "label": "methods", "text": "General and orthopedic surgery patients ( n = @ ) were randomized to standard - or battery-powered SCDs .", "sentence_id": 1}
+{"abstract_id": "25812845", "label": "methods", "text": "Compliance was documented hourly .", "sentence_id": 2}
+{"abstract_id": "25812845", "label": "methods", "text": "Nurses and patients were issued a survey to assess barriers to compliance and device satisfaction .", "sentence_id": 3}
+{"abstract_id": "25812845", "label": "results", "text": "Compliance with standard SCDs was @ % compared with @ % with battery-powered SCDs ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25812845", "label": "results", "text": "The most common barriers identified by nurses and patients were ambulation and transfers , which were mitigated with the battery-powered device .", "sentence_id": 5}
+{"abstract_id": "25812845", "label": "results", "text": "A majority ( @ % ) of those issued a battery-powered device reported no major problems compared with only @ % of patients issued a standard device ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25812845", "label": "conclusions", "text": "The dual venous thromboembolism prevention strategies of early mobilization and SCD utilization can be met with the appropriate equipment .", "sentence_id": 7}
+{"abstract_id": "25300507", "label": "objective", "text": "The aim of this study was to evaluate the cost effectiveness of ranibizumab compared with verteporfin photodynamic therapy ( vPDT ) or no treatment ( observation ) in patients with visual impairment due to myopic choroidal neovascularization ( CNV ) .", "sentence_id": 0}
+{"abstract_id": "25300507", "label": "methods", "text": "A Markov model with health states defined by best-corrected visual acuity and a @-month cycle length was developed .", "sentence_id": 1}
+{"abstract_id": "25300507", "label": "methods", "text": "It had a healthcare provider ( UK National Health Service and personal social services ) perspective , a lifetime time horizon , and was based on @ prices ; future costs and health outcomes were discounted at @ % per annum .", "sentence_id": 2}
+{"abstract_id": "25300507", "label": "methods", "text": "Baseline characteristics were based on the phase III RADIANCE ( Ranibizumab and vPDT Evaluation in Myopic CNV ) study , and year @ health-state transitions were based on this and the VIP ( Verteporfin in Photodynamic Therapy ) study .", "sentence_id": 3}
+{"abstract_id": "25300507", "label": "methods", "text": "Extensive sensitivity analyses tested the robustness of the model .", "sentence_id": 4}
+{"abstract_id": "25300507", "label": "results", "text": "The lifetime cost of treating myopic CNV with ranibizumab was @,@ , whereas vPDT and observation were associated with total costs of @,@ and @,@ , respectively .", "sentence_id": 5}
+{"abstract_id": "25300507", "label": "results", "text": "Ranibizumab treatment produced higher cumulative quality-adjusted life-years ( QALYs ; @ ) than vPDT ( @ ) or observation ( @ ) .", "sentence_id": 6}
+{"abstract_id": "25300507", "label": "results", "text": "Ranibizumab treatment was therefore dominant , with greater health gains and lower overall costs than vPDT .", "sentence_id": 7}
+{"abstract_id": "25300507", "label": "results", "text": "Ranibizumab was cost effective compared with observation , with an incremental cost-effectiveness ratio of @,@ / QALY .", "sentence_id": 8}
+{"abstract_id": "25300507", "label": "results", "text": "In the probabilistic sensitivity analysis , ranibizumab had a @ % and @ % probability of being cost effective compared with vPDT and observation , respectively , at a willingness-to-pay threshold of @,@ / QALY .", "sentence_id": 9}
+{"abstract_id": "25300507", "label": "conclusions", "text": "This study indicates that ranibizumab therapy is dominant over vPDT for the treatment of visual impairment due to CNV secondary to pathologic myopia in the UK healthcare setting and cost effective compared with observation .", "sentence_id": 10}
+{"abstract_id": "25583754", "label": "objective", "text": "To evaluate the efficacy and safety of combinations of empagliflozin/linagliptin as second-line therapy in subjects with type @ diabetes inadequately controlled on metformin .", "sentence_id": 0}
+{"abstract_id": "25583754", "label": "methods", "text": "Subjects were randomized to a combination of empagliflozin @ mg/linagliptin @ mg ( n = @ ) , empagliflozin @ mg/linagliptin @ mg ( n = @ ) , empagliflozin @ mg ( n = @ ) , empagliflozin @ mg ( n = @ ) , or linagliptin @ mg ( n = @ ) as add-on to metformin for @ weeks .", "sentence_id": 1}
+{"abstract_id": "25583754", "label": "methods", "text": "The primary end point was change from baseline in HbA@c at week @ .", "sentence_id": 2}
+{"abstract_id": "25583754", "label": "results", "text": "At week @ , reductions in HbA@c ( mean baseline @-@ @ % -LSB- @-@ @ mmol/mol -RSB- ) with empagliflozin/linagliptin were superior to those with empagliflozin or linagliptin alone as add-on to metformin ; adjusted mean ( SE ) changes from baseline were -@ % ( @ ) ( -@ mmol/mol -LSB- @ -RSB- ) with empagliflozin @ mg/linagliptin @ mg , -@ % ( @ ) ( -@ mmol/mol -LSB- @ -RSB- ) with empagliflozin @ mg/linagliptin @ mg , -@ % ( @ ) ( -@ mmol/mol -LSB- @ -RSB- ) with empagliflozin @ mg , -@ % ( @ ) ( -@ mmol/mol -LSB- @ -RSB- ) with empagliflozin @ mg , and -@ % ( @ ) ( -@ mmol/mol -LSB- @ -RSB- ) with linagliptin @ mg ( P < @ for all comparisons ) .", "sentence_id": 3}
+{"abstract_id": "25583754", "label": "results", "text": "In these groups , respectively , @ , @ , @ , @ , and @ % of subjects with baseline HbA@c @ % ( @ mmol/mol ) had HbA@c < @ % ( < @ mmol/mol ) at week @ .", "sentence_id": 4}
+{"abstract_id": "25583754", "label": "results", "text": "Efficacy was maintained at week @ .", "sentence_id": 5}
+{"abstract_id": "25583754", "label": "results", "text": "The proportion of subjects with adverse events ( AEs ) over @ weeks was similar across treatment arms ( @-@ @ % ) , with no hypoglycemic AEs requiring assistance .", "sentence_id": 6}
+{"abstract_id": "25583754", "label": "conclusions", "text": "Combinations of empagliflozin/linagliptin as second-line therapy for @ weeks significantly reduced HbA@c compared with the individual components and were well tolerated .", "sentence_id": 7}
+{"abstract_id": "25065535", "label": "background", "text": "Cannabis use is high amongst young people who have recently had their first episode of psychosis , and is associated with worse outcomes .", "sentence_id": 0}
+{"abstract_id": "25065535", "label": "background", "text": "To date , interventions to reduce cannabis consumption have been largely ineffective , and it has been suggested that longer treatment periods are required .", "sentence_id": 1}
+{"abstract_id": "25065535", "label": "methods", "text": "In a pragmatic single-blind randomized controlled trial @ participants were randomly allocated to one of three conditions : a brief motivational interviewing and cognitive behavioural therapy ( MI-CBT ) intervention ( up to @ sessions over @ months ) with standard care from an early intervention service ; a long MI-CBT intervention ( up to @ sessions over @ months ) with standard care ; or standard care alone .", "sentence_id": 2}
+{"abstract_id": "25065535", "label": "methods", "text": "The primary outcome was change in cannabis use as measured by Timeline Followback .", "sentence_id": 3}
+{"abstract_id": "25065535", "label": "results", "text": "Neither the extended nor the brief interventions conferred benefit over standard care in terms of reductions in frequency or amount of cannabis use .", "sentence_id": 4}
+{"abstract_id": "25065535", "label": "results", "text": "Also the interventions did not result in improvements in the assessed clinical outcomes , including symptoms , functioning , hospital admissions or relapse .", "sentence_id": 5}
+{"abstract_id": "25065535", "label": "conclusions", "text": "Integrated MI and CBT for people with cannabis use and recent-onset psychosis does not reduce cannabis use or improve clinical outcomes .", "sentence_id": 6}
+{"abstract_id": "25065535", "label": "conclusions", "text": "These findings are consistent with those in the published literature , and additionally demonstrate that offering a more extended intervention does not confer any advantage .", "sentence_id": 7}
+{"abstract_id": "25065535", "label": "conclusions", "text": "Many participants were not at an action stage for change and for those not ready to reduce or quit cannabis , targeting associated problems rather than the cannabis use per se may be the best current strategy for mental health services to adopt .", "sentence_id": 8}
+{"abstract_id": "25882438", "label": "objective", "text": "Emerging evidence has suggested that platelet-rich plasma ( PRP ) might be of assistance in the treatment of degenerative conditions of the joints .", "sentence_id": 0}
+{"abstract_id": "25882438", "label": "objective", "text": "The aim of the present study was to compare the use of PRP and hyaluronic acid ( HA ) in the treatment of temporomandibular joint ( TMJ ) osteoarthritis ( OA ) with long-term follow-up data .", "sentence_id": 1}
+{"abstract_id": "25882438", "label": "methods", "text": "Patients meeting the Research Diagnostic Criteria for TMJ-OA were randomly assigned to @ of @ study groups that received either PRP or HA .", "sentence_id": 2}
+{"abstract_id": "25882438", "label": "methods", "text": "The outcome variables were maximum nonassisted ( voluntary ) mouth opening ( MVMO ) , joint sounds , and pain index scores .", "sentence_id": 3}
+{"abstract_id": "25882438", "label": "methods", "text": "Other variables , including patient age and gender , were evaluated in relation to the outcomes .", "sentence_id": 4}
+{"abstract_id": "25882438", "label": "methods", "text": "Descriptive and bivariate statistics were computed , and the P value was set at @ .", "sentence_id": 5}
+{"abstract_id": "25882438", "label": "results", "text": "A total of @ patients with TMJ-OA were enrolled in the study ( @ women and @ men , age range @ to @ years , mean age @ ) .", "sentence_id": 6}
+{"abstract_id": "25882438", "label": "results", "text": "In group I , @ patients received @ injections of @ mL of PRP .", "sentence_id": 7}
+{"abstract_id": "25882438", "label": "results", "text": "In group II , @ patients received @ injections of @ mL of low-molecular-weight HA .", "sentence_id": 8}
+{"abstract_id": "25882438", "label": "results", "text": "Between-group comparisons of the outcome variables over time revealed significant improvements in group II at @ and @ months .", "sentence_id": 9}
+{"abstract_id": "25882438", "label": "results", "text": "At @ and @ months , the PRP group exhibited better performance compared with the HA group in terms of the recurrence of pain and joint sounds .", "sentence_id": 10}
+{"abstract_id": "25882438", "label": "results", "text": "The improvements obtained with the PRP injections in group I were maintained during the follow-up period .", "sentence_id": 11}
+{"abstract_id": "25882438", "label": "results", "text": "At the end of the follow-up period , the median MVMO in group I was @ mm .", "sentence_id": 12}
+{"abstract_id": "25882438", "label": "results", "text": "In group II , the median MVMO was @ mm .", "sentence_id": 13}
+{"abstract_id": "25882438", "label": "conclusions", "text": "PRP performed better than HA acid in the treatment of TMJ-OA during long-term follow-up in terms of pain reduction and increased interincisal distance .", "sentence_id": 14}
+{"abstract_id": "25882438", "label": "conclusions", "text": "Future studies will focus on the synergistic actions of HA and PRP in the treatment of TMJ-OA .", "sentence_id": 15}
+{"abstract_id": "24247476", "label": "objective", "text": "Intensive insulin therapy for tight glycemic control in critically ill surgical patients has been shown to reduce mortality ; however , intensive insulin therapy is associated with iatrogenic hypoglycemia and increased variability of blood glucose levels .", "sentence_id": 0}
+{"abstract_id": "24247476", "label": "objective", "text": "The incretin glucagon-like peptide-@ ( @-@ ) amide is both insulinotropic and insulinomimetic and has been suggested as an adjunct to improve glycemic control in critically ill patients .", "sentence_id": 1}
+{"abstract_id": "24247476", "label": "objective", "text": "We hypothesized that the addition of continuous infusion of glucagon-like peptide-@ to intensive insulin therapy would result in better glucose control , reduced requirement of exogenous insulin administration , and fewer hypoglycemic events .", "sentence_id": 2}
+{"abstract_id": "24247476", "label": "methods", "text": "Prospective , randomized , double-blind , placebo-controlled clinical trial .", "sentence_id": 3}
+{"abstract_id": "24247476", "label": "methods", "text": "Surgical or burn ICU .", "sentence_id": 4}
+{"abstract_id": "24247476", "label": "methods", "text": "Eighteen patients who required intensive insulin therapy .", "sentence_id": 5}
+{"abstract_id": "24247476", "label": "methods", "text": "A @-hour continuous infusion of either glucagon-like peptide-@ ( @ pmol/kg/min ) or normal saline plus intensive insulin therapy .", "sentence_id": 6}
+{"abstract_id": "24247476", "label": "results", "text": "The glucagon-like peptide-@ cohort ( n = @ ) and saline cohort ( n = @ ) were similar in age , Acute Physiology and Chronic Health Evaluation score , and history of diabetes .", "sentence_id": 7}
+{"abstract_id": "24247476", "label": "results", "text": "Blood glucose levels in the glucagon-like peptide-@ group were better controlled with much less variability .", "sentence_id": 8}
+{"abstract_id": "24247476", "label": "results", "text": "The coefficient of variation of blood glucose ranged from @ % to @ % in the glucagon-like peptide-@ group and from @ % to @ % in saline group .", "sentence_id": 9}
+{"abstract_id": "24247476", "label": "results", "text": "The mean blood glucose coefficient of variation for the glucagon-like peptide-@ and saline groups was @ % @ % and @ % @ % ( p = @ ) , respectively .", "sentence_id": 10}
+{"abstract_id": "24247476", "label": "results", "text": "The @-hour average insulin infusion rates were @ @ and @ @ U/hr ( p = not significant ) .", "sentence_id": 11}
+{"abstract_id": "24247476", "label": "results", "text": "The incidents of hypoglycemia ( @ mmol/L ) in both groups were low ( one in the glucagon-like peptide-@ group , three in the saline group ) .", "sentence_id": 12}
+{"abstract_id": "24247476", "label": "conclusions", "text": "Glucagon-like peptide-@ ( @-@ ) amide is a safe and efficacious form of adjunct therapy in patients with hyperglycemia in the surgical ICU setting .", "sentence_id": 13}
+{"abstract_id": "24247476", "label": "conclusions", "text": "Improved stability of blood glucose is a favorable outcome , which enhances the safety of intensive insulin therapy .", "sentence_id": 14}
+{"abstract_id": "24247476", "label": "conclusions", "text": "Larger studies of this potentially valuable therapy for glycemic control in the ICU are justified .", "sentence_id": 15}
+{"abstract_id": "24666774", "label": "objective", "text": "In a randomized controlled trial of a preoperative education intervention conducted for Chinese cardiac patients , we observed a greater effect on symptoms of anxiety and depression than that reported with regard to similar interventions in western care settings .", "sentence_id": 0}
+{"abstract_id": "24666774", "label": "objective", "text": "The objective of this qualitative study was to help explain the findings of the trial by exploring Chinese patients ' experience of seeking and receiving information before cardiac surgery .", "sentence_id": 1}
+{"abstract_id": "24666774", "label": "methods", "text": "Semi-structured interviews were conducted with a purposive sample of @ trial participants before discharge ( ten from the preoperative education group ; ten from the usual care control group ) .", "sentence_id": 2}
+{"abstract_id": "24666774", "label": "methods", "text": "Data were analyzed using a thematic analysis approach .", "sentence_id": 3}
+{"abstract_id": "24666774", "label": "results", "text": "A total of five themes were generated : the role of reputation and hierarchy ; gaining strength from knowledge ; information as a low priority ; being kept in the dark ; and learning through peer support .", "sentence_id": 4}
+{"abstract_id": "24666774", "label": "conclusions", "text": "In health care systems where service users are given relatively little information , interventions designed to inform patients about their treatment are likely to have a much greater impact on their psychological health .", "sentence_id": 5}
+{"abstract_id": "24666774", "label": "conclusions", "text": "Providers of services for patients undergoing cardiac surgery in China should be encouraged to incorporate information giving into routine practice , tailored according to individual need .", "sentence_id": 6}
+{"abstract_id": "25056465", "label": "objective", "text": "To compare two incision angles ( @ vs @ ) of mediolateral episiotomy in primiparous Egyptian women , regarding the incidence of anal sphincter injury as well as episiotomy-related pain and dyspareunia .", "sentence_id": 0}
+{"abstract_id": "25056465", "label": "methods", "text": "The current prospective randomized controlled trial ( ClinicalTrials.gov , NCT@ ) was conducted at Ain Shams University Maternity Hospital .", "sentence_id": 1}
+{"abstract_id": "25056465", "label": "methods", "text": "Eligible women were randomized into two groups : group @ included women who had the episiotomy incision made at an angle of @ to the midline ; and group @ included women who had the episiotomy incision made at an angle of @ to the midline .", "sentence_id": 2}
+{"abstract_id": "25056465", "label": "methods", "text": "Primary outcome measures were differences in short-term related pain and rate of third/fourth degree perineal tears .", "sentence_id": 3}
+{"abstract_id": "25056465", "label": "results", "text": "A total of @ primiparous women were recruited .", "sentence_id": 4}
+{"abstract_id": "25056465", "label": "results", "text": "The shortest distance to the outer edge of the anal epithelium was significantly shorter in women of group @ when compared to that in women of group @ .", "sentence_id": 5}
+{"abstract_id": "25056465", "label": "results", "text": "Out of the included @ women , @ ( @ % ) had third/fourth-degree perineal tears ( @ -LSB- @ % -RSB- in group @ in contrast to nine -LSB- @ % -RSB- in group @ ) .", "sentence_id": 6}
+{"abstract_id": "25056465", "label": "results", "text": "This difference was not significant A @-angled mediolateral episiotomy was associated with significantly higher rates of moderate/severe episiotomy-related pain post-partum .", "sentence_id": 7}
+{"abstract_id": "25056465", "label": "results", "text": "The rates of moderate/severe episiotomy-related pain and dyspareunia assessed @ months post-partum were also higher among women of group @ , when compared to group @ ; the latter two differences did not reach statistical significance , however .", "sentence_id": 8}
+{"abstract_id": "25056465", "label": "conclusions", "text": "When compared to the @-angled mediolateral episiotomies , @-angled ones were associated with significantly higher short-term-related pain .", "sentence_id": 9}
+{"abstract_id": "25056465", "label": "conclusions", "text": "Although they were also associated with lower rate of third/fourth-degree perineal tears and higher rate of long-term related pain and dyspareunia , these differences did not reach a statistically significant level .", "sentence_id": 10}
+{"abstract_id": "24486366", "label": "objective", "text": "A suboptimal level of seasonal influenza vaccination among pregnant minority women is an intractable public health problem , requiring effective message resonance with this population .", "sentence_id": 0}
+{"abstract_id": "24486366", "label": "objective", "text": "We evaluated the effects of randomized exposure to messages which emphasize positive outcomes of vaccination ( `` gain-frame '' ) , or messages which emphasize negative outcomes of forgoing vaccination ( `` loss-frame '' ) .", "sentence_id": 1}
+{"abstract_id": "24486366", "label": "objective", "text": "We also assessed multilevel social and community factors that influence maternal immunization among racially and ethnically diverse populations .", "sentence_id": 2}
+{"abstract_id": "24486366", "label": "methods", "text": "Minority pregnant women in metropolitan Atlanta were enrolled in the longitudinal study and randomized to receive intervention or control messages .", "sentence_id": 3}
+{"abstract_id": "24486366", "label": "methods", "text": "A postpartum questionnaire administered @ days postpartum evaluated immunization outcomes following baseline message exposure among the study population .", "sentence_id": 4}
+{"abstract_id": "24486366", "label": "methods", "text": "We evaluated key outcomes using bivariate and multivariate analyses .", "sentence_id": 5}
+{"abstract_id": "24486366", "label": "results", "text": "Neither gain - -LSB- OR = @ , ( @ % CI : @,@ ) -RSB- nor loss-framed -LSB- OR = @ , @ % CI : ( @,@ ) -RSB- messages were significantly associated with increased likelihood of immunization during pregnancy .", "sentence_id": 6}
+{"abstract_id": "24486366", "label": "results", "text": "Significant correlates of seasonal influenza immunization during pregnancy included healthcare provider recommendation -LSB- OR = @ , @ % CI : ( @,@ ) -RSB- , use of hospital-based practices as primary source of prenatal care -LSB- OR = @ , @ % CI : ( @,@ ) -RSB- , and perceived interpersonal support for influenza immunization -LSB- OR = @ , @ % CI : ( @,@ ) -RSB- .", "sentence_id": 7}
+{"abstract_id": "24486366", "label": "conclusions", "text": "Dissemination of vaccine education messages via healthcare providers , and cultivating support from social networks , will improve seasonal influenza immunization among pregnant minority women .", "sentence_id": 8}
+{"abstract_id": "24833315", "label": "objective", "text": "This randomised clinical trial assessed the effects of a @-week cognitive remediation programme ( NEUROCOM ) combined with an early intervention service ( EIS ) vs. EIS alone .", "sentence_id": 0}
+{"abstract_id": "24833315", "label": "methods", "text": "One hundred and seventeen patients with first episode psychosis were randomly assigned to @ months cognitive remediation combined with EIS vs. EIS alone .", "sentence_id": 1}
+{"abstract_id": "24833315", "label": "methods", "text": "Statistical analysis of effect was based on intention to treat .", "sentence_id": 2}
+{"abstract_id": "24833315", "label": "results", "text": "A total of @ patients ( @ % ) participated in post-training assessments at @ months and @ ( @ % ) in @-month follow-up assessments .", "sentence_id": 3}
+{"abstract_id": "24833315", "label": "results", "text": "No effects were found on the primary outcome measure functional capacity .", "sentence_id": 4}
+{"abstract_id": "24833315", "label": "results", "text": "At the post-training assessment , the intervention group had improved significantly on Rosenberg Self-Esteem Scale ( Cohen 's d = @ , P = @ ) , Positive and Negative Symptoms Scale ( PANSS ) , General Psychopathology Scale ( Cohen 's d = @ , P = @ ) and the verbal learning domain ( Cohen 's d = @ , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24833315", "label": "results", "text": "At follow-up assessment , the intervention group retained the significant improvements on the verbal learning domain ( Cohen 's d = @ , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24833315", "label": "results", "text": "Furthermore , significant improvements were observed on the working memory domain ( Cohen 's d = @ , P = @ ) and PANSS positive symptoms ( Cohen 's d = @ , P = @ ) , while improvement on the composite score was marginally significant ( Cohen 's d = @ , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24833315", "label": "conclusions", "text": "In accordance with other cognitive remediation programmes , this programme demonstrates some immediate and long-term effect on cognitive functioning , symptoms and self-esteem .", "sentence_id": 8}
+{"abstract_id": "25065337", "label": "background", "text": "In previous studies , we identified two urinary proteomic classifiers , termed HF@ and HF@ , which discriminated subclinical diastolic left ventricular ( LV ) dysfunction from normal .", "sentence_id": 0}
+{"abstract_id": "25065337", "label": "background", "text": "HF@ and HF@ combine information from @ and @ urinary peptides , mainly up - or down-regulated collagen fragments .", "sentence_id": 1}
+{"abstract_id": "25065337", "label": "background", "text": "We sought to validate these classifiers in a population study .", "sentence_id": 2}
+{"abstract_id": "25065337", "label": "methods", "text": "In @ people randomly recruited from a Flemish population ( @ years ; @ % women ) , we measured early and late diastolic peak velocities of mitral inflow ( E and A ) and mitral annular velocities ( e ' and a ' ) by conventional and tissue Doppler echocardiography , and the urinary proteome by capillary electrophoresis coupled with mass spectrometry .", "sentence_id": 3}
+{"abstract_id": "25065337", "label": "results", "text": "In the analyses adjusted for sex , age , body mass index , blood pressure , heart rate , LV mass index and intake of medications , we expressed effect sizes per @-SD increment in the classifiers .", "sentence_id": 4}
+{"abstract_id": "25065337", "label": "results", "text": "HF@ was associated with @ cm/s lower e ' peak velocity ( @ % confidence interval , @-@ @ ; p = @ ) and @ higher E/e ' ratio ( @-@ @ ; p = @ ) , while HF@ was associated with a @ higher E/e ' ratio ( @-@ @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25065337", "label": "results", "text": "According to published definitions , @ ( @ % ) participants had impaired LV relaxation and @ ( @ % ) had elevated LV filling pressure .", "sentence_id": 6}
+{"abstract_id": "25065337", "label": "results", "text": "The odds of impaired relaxation associated with HF@ was @ ( @-@ @ ; p = @ ) and that of increased LV filling pressure associated with HF@ was @ ( @-@ @ ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25065337", "label": "conclusions", "text": "In a general population , the urinary proteome correlated with diastolic LV dysfunction , proving its utility for early diagnosis of this condition .", "sentence_id": 8}
+{"abstract_id": "25061702", "label": "objective", "text": "To evaluate the pharmacokinetics and thermal and mechanical antinociceptive effects of a fentanyl constant rate infusion ( CRI ) in conscious cats .", "sentence_id": 0}
+{"abstract_id": "25061702", "label": "methods", "text": "@ healthy adult cats .", "sentence_id": 1}
+{"abstract_id": "25061702", "label": "methods", "text": "At a @-day interval , @ cats received a loading dose ( LD ) of fentanyl ( @ g/kg , IV -LSB- administered at @ hours -RSB- ) followed by fentanyl infusion ( @ g/kg/h , IV ) for @ hours or similar administrations of equivalent volumes of @ % saline ( NaCl ) solution .", "sentence_id": 2}
+{"abstract_id": "25061702", "label": "methods", "text": "One cat received only the fentanyl treatment .", "sentence_id": 3}
+{"abstract_id": "25061702", "label": "methods", "text": "For both treatments , sedation and adverse events were evaluated and mechanical threshold ( MT ) and thermal threshold ( TT ) testing was performed prior to ( baseline ) and at predetermined times up to @ hours after LD administration ; plasma fentanyl concentrations were determined at similar times when the cats received fentanyl .", "sentence_id": 4}
+{"abstract_id": "25061702", "label": "results", "text": "Fentanyl induced mild sedation during the infusion .", "sentence_id": 5}
+{"abstract_id": "25061702", "label": "results", "text": "The only adverse effect associated with fentanyl LD administration was profuse salivation ( @ cat ) .", "sentence_id": 6}
+{"abstract_id": "25061702", "label": "results", "text": "Saline solution administration did not significantly change MT or TT over time .", "sentence_id": 7}
+{"abstract_id": "25061702", "label": "results", "text": "For the duration of the CRI , MT and TT differed significantly between treatments , except for TT @ hour after LD administration .", "sentence_id": 8}
+{"abstract_id": "25061702", "label": "results", "text": "For the fentanyl treatment , MT and TT were significantly higher than baseline at @ to @ hours and at @ to @ hour , respectively .", "sentence_id": 9}
+{"abstract_id": "25061702", "label": "results", "text": "During the fentanyl CRI , mean SD plasma fentanyl concentration decreased from @ @ ng/mL to @ @ ng/mL and was correlated with antinociception ; plasma concentrations < @ @ ng/mL were not associated with antinociception .", "sentence_id": 10}
+{"abstract_id": "25061702", "label": "conclusions", "text": "Fentanyl CRI ( @ g/kg/h ) induced mechanical and thermal antinociception in cats .", "sentence_id": 11}
+{"abstract_id": "24882698", "label": "background", "text": "To investigate the performance of the MI Sxscore in a multicentre randomised trial of patients undergoing primary percutaneous coronary intervention ( PPCI ) .", "sentence_id": 0}
+{"abstract_id": "24882698", "label": "results", "text": "The MI Sxscore was prospectively determined among @ STEMI patients enrolled into the COMFORTABLE AMI trial , which randomised patients to treatment with bare-metal ( BMS ) or biolimus-eluting ( BES ) stents .", "sentence_id": 1}
+{"abstract_id": "24882698", "label": "results", "text": "Patient - ( death , myocardial infarction , any revascularisation ) and device-oriented ( cardiac death , target-vessel MI , target lesion revascularisation ) major adverse cardiac events ( MACEs ) were compared across MI Sxscore tertiles and according to stent type .", "sentence_id": 2}
+{"abstract_id": "24882698", "label": "results", "text": "The median MI SXscore was @ ( IQR : @-@ ) .", "sentence_id": 3}
+{"abstract_id": "24882698", "label": "results", "text": "Patients were divided into tertiles of Sxscorelow ( @ ) , Sxscoreintermediate ( @-@ ) and Sxscorehigh ( @ ) .", "sentence_id": 4}
+{"abstract_id": "24882698", "label": "results", "text": "At @ year , patient-oriented MACE occurred in @ % of the Sxscorehigh , @ % of the Sxscoreintermediate and @ % of the Sxscorelow tertiles ( p < @ ) , whereas device-oriented MACE occurred in @ % of the Sxscorehigh , @ % of the Sxscoreintermediate and @ % of the Sxscorelow tertiles ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24882698", "label": "results", "text": "Addition of the MI Sxscore to the TIMI risk score improved prediction of patient - ( c-statistic value increase from @ to @ ) and device-oriented MACEs ( c-statistic value increase from @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "24882698", "label": "results", "text": "Differences in the risk for device-oriented MACE between BMS and BES were evident among Sxscorehigh ( @ % vs. @ % HR @ ( @-@ @ ) , p = @ rather than those in Sxscorelow : @ % vs. @ % HR @ ( @-@ @ ) , p = @ ) tertiles .", "sentence_id": 7}
+{"abstract_id": "24882698", "label": "conclusions", "text": "The MI Sxscore allows risk stratification of patient - and device-oriented MACEs among patients undergoing PPCI .", "sentence_id": 8}
+{"abstract_id": "24882698", "label": "conclusions", "text": "The addition of the MI Sxscore to the TIMI risk score is of incremental prognostic value among patients undergoing PPCI for treatment of STEMI .", "sentence_id": 9}
+{"abstract_id": "24949605", "label": "objective", "text": "To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate ( PMC ) and polyethylene glycol ( PEG ) in a single or split dose regimen for colonoscopy bowel preparation .", "sentence_id": 0}
+{"abstract_id": "24949605", "label": "methods", "text": "A prospective , randomized , endoscopist-blinded , multicenter study .", "sentence_id": 1}
+{"abstract_id": "24949605", "label": "methods", "text": "The patients were randomly assigned to receive PMC ( PMC@/@ ) or PEG ( PEG@/@ ) in a single dose @L day before colonoscopy or a split dose @ +@ L PMC ( PMC@/@ ) or @ +@ L PEG ( PEG@/@ ) one day before and in the morning before the colonoscopy .", "sentence_id": 2}
+{"abstract_id": "24949605", "label": "methods", "text": "Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure .", "sentence_id": 3}
+{"abstract_id": "24949605", "label": "methods", "text": "The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale .", "sentence_id": 4}
+{"abstract_id": "24949605", "label": "results", "text": "A total of @ patients were enrolled , @ % were included in the analysis .", "sentence_id": 5}
+{"abstract_id": "24949605", "label": "results", "text": "Satisfactory bowel cleansing ( Aronchick score @ and @ ) was significantly more frequent when a split dose was used irrespective of the solution type ( @ % PMC@/@ , @ % PEG@/@ vs. @ % PEG@/@ , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24949605", "label": "results", "text": "In single dose regimens , PMC performed better than PEG ( @ % vs. @ % ) .", "sentence_id": 7}
+{"abstract_id": "24949605", "label": "results", "text": "Single or split dose PMC preparations were comparable .", "sentence_id": 8}
+{"abstract_id": "24949605", "label": "results", "text": "A PMC based solution was generally better tolerated than PEG regardless of the regimen used ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "24949605", "label": "results", "text": "Nausea was reported mostly after the @L PEG ( @ % , p < @ ) , incontinence after a split PMC dose ( @ % , p = @ ) , and bloating after the @L PEG ( @ % , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24949605", "label": "results", "text": "There was no significant difference in the prevalence of vomiting .", "sentence_id": 11}
+{"abstract_id": "24949605", "label": "conclusions", "text": "Colonic preparation with PMC yields similar results as a split PEG dose , regardless of whether PMC is administered in single or separate doses .", "sentence_id": 12}
+{"abstract_id": "24949605", "label": "conclusions", "text": "PMC is better tolerated than any PEG-based preparation .", "sentence_id": 13}
+{"abstract_id": "24949605", "label": "conclusions", "text": "A single @L PEG the day before the colonoscopy is less appropriate for bowel cleansing .", "sentence_id": 14}
+{"abstract_id": "25611785", "label": "background", "text": "Chronic obstructive pulmonary disease ( COPD ) is a heterogeneous disease and likely includes a subgroup that is biologically comparable to asthma .", "sentence_id": 0}
+{"abstract_id": "25611785", "label": "background", "text": "Studying asthma-associated gene expression changes in COPD could add insight into COPD pathogenesis and reveal biomarkers that predict a favorable response to corticosteroids .", "sentence_id": 1}
+{"abstract_id": "25611785", "label": "objective", "text": "To determine whether asthma-associated gene signatures are increased in COPD and associated with asthma-related features .", "sentence_id": 2}
+{"abstract_id": "25611785", "label": "methods", "text": "We compared disease-associated airway epithelial gene expression alterations in an asthma cohort ( n = @ ) and two COPD cohorts ( n = @ , @ ) .", "sentence_id": 3}
+{"abstract_id": "25611785", "label": "methods", "text": "The T helper type @ ( Th@ ) signature ( T@S ) score , a gene expression metric induced in Th@-high asthma , was evaluated in these COPD cohorts .", "sentence_id": 4}
+{"abstract_id": "25611785", "label": "methods", "text": "The T@S score was correlated with asthma-related features and response to corticosteroids in COPD in a randomized , placebo-controlled trial , the Groningen and Leiden Universities study of Corticosteroids in Obstructive Lung Disease ( GLUCOLD ; n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25611785", "label": "results", "text": "The @ genes most differentially expressed in asthma versus healthy control subjects were enriched among genes associated with more severe airflow obstruction in these COPD cohorts ( P < @ ) , suggesting significant gene expression overlap .", "sentence_id": 6}
+{"abstract_id": "25611785", "label": "results", "text": "A higher T@S score was associated with decreased lung function ( P < @ ) , but not asthma history , in both COPD cohorts .", "sentence_id": 7}
+{"abstract_id": "25611785", "label": "results", "text": "Higher T@S scores correlated with increased airway wall eosinophil counts ( P = @ ) , blood eosinophil percentage ( P = @ ) , bronchodilator reversibility ( P = @ ) , and improvement in hyperinflation after corticosteroid treatment ( P = @ ) in GLUCOLD .", "sentence_id": 8}
+{"abstract_id": "25611785", "label": "conclusions", "text": "These data identify airway gene expression alterations that can co-occur in asthma and COPD .", "sentence_id": 9}
+{"abstract_id": "25611785", "label": "conclusions", "text": "The association of the T@S score with increased severity and `` asthma-like '' features ( including a favorable corticosteroid response ) in COPD suggests that Th@ inflammation is important in a COPD subset that can not be identified by clinical history of asthma .", "sentence_id": 10}
+{"abstract_id": "24359938", "label": "objective", "text": "To compare the efficacy and safety of oral paracetamol and oral ibuprofen for the pharmacological closure of patent ductus arteriosus ( PDA ) in preterm infants .", "sentence_id": 0}
+{"abstract_id": "24359938", "label": "methods", "text": "This prospective , randomized , controlled study enrolled @ preterm infants with gestational age @ weeks , birthweight @ g , and postnatal age @ to @ hours who had echocardiographically confirmed significant PDA .", "sentence_id": 1}
+{"abstract_id": "24359938", "label": "methods", "text": "Each enrolled patient received either oral paracetamol ( @ mg/kg every @ hours for @ days ) or oral ibuprofen ( initial dose of @ mg/kg , followed by @ mg/kg at @ and @ hours ) .", "sentence_id": 2}
+{"abstract_id": "24359938", "label": "results", "text": "Spontaneous closure rate for the entire study group was @ % .", "sentence_id": 3}
+{"abstract_id": "24359938", "label": "results", "text": "After the first course of treatment , the PDA closed in @ ( @ % ) of the patients assigned to the oral ibuprofen group vs @ ( @ % ) of those enrolled in the oral paracetamol group ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24359938", "label": "results", "text": "The reopening rate was higher in the paracetamol group than in the ibuprofen group , but the reopening rates were not statistically different ( @ % -LSB- @ of @ -RSB- vs @ % -LSB- @ of @ -RSB- ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24359938", "label": "results", "text": "The cumulative closure rates after the second course of drugs were high in both groups .", "sentence_id": 6}
+{"abstract_id": "24359938", "label": "results", "text": "Only @ patient ( @ % ) in the paracetamol group and @ patients ( @ % ) in the ibuprofen group required surgical ligation .", "sentence_id": 7}
+{"abstract_id": "24359938", "label": "conclusions", "text": "This randomized , controlled clinical study compared oral paracetamol with ibuprofen in preterm infants and demonstrated that paracetamol may be a medical alternative in the management of PDA .", "sentence_id": 8}
+{"abstract_id": "25054836", "label": "objective", "text": "Select cases of intractable obsessive-compulsive disorder ( OCD ) have undergone neurosurgical ablation for more than half a century .", "sentence_id": 0}
+{"abstract_id": "25054836", "label": "objective", "text": "However , to our knowledge , there have been no randomized clinical trials of such procedures for the treatment of any psychiatric disorder .", "sentence_id": 1}
+{"abstract_id": "25054836", "label": "objective", "text": "To determine the efficacy and safety of a radiosurgery ( gamma ventral capsulotomy -LSB- GVC -RSB- ) for intractable OCD .", "sentence_id": 2}
+{"abstract_id": "25054836", "label": "methods", "text": "In a double-blind , placebo-controlled , randomized clinical trial , @ patients with intractable OCD were randomized to active ( n = @ ) or sham ( n = @ ) GVC .", "sentence_id": 3}
+{"abstract_id": "25054836", "label": "methods", "text": "Blinding was maintained for @ months .", "sentence_id": 4}
+{"abstract_id": "25054836", "label": "methods", "text": "After unblinding , sham-group patients were offered active GVC .", "sentence_id": 5}
+{"abstract_id": "25054836", "label": "methods", "text": "Patients randomized to active GVC had @ distinct isocenters on each side irradiated at the ventral border of the anterior limb of the internal capsule .", "sentence_id": 6}
+{"abstract_id": "25054836", "label": "methods", "text": "The patients randomized to sham GVC received simulated radiosurgery using the same equipment .", "sentence_id": 7}
+{"abstract_id": "25054836", "label": "methods", "text": "Scores on the Yale-Brown Obsessive-Compulsive Scale ( Y-BOCS ) and the Clinical Global Impression-Improvement ( CGI-I ) Scale .", "sentence_id": 8}
+{"abstract_id": "25054836", "label": "methods", "text": "Response was defined as a @ % or greater reduction in Y-BOCS severity and `` improved '' or `` much improved '' CGI-I ratings .", "sentence_id": 9}
+{"abstract_id": "25054836", "label": "results", "text": "Three of @ patients randomized to active treatment responded at @ months , while none of the @ sham-GVC patients responded ( absolute risk reduction , @ ; @ % CI , @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "25054836", "label": "results", "text": "At @ months , OCD symptom improvement was significantly higher in the active-GVC group than in the sham group ( Y-BOCS , P = @ ; Dimensional Y-BOCS , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25054836", "label": "results", "text": "At @ months , @ additional patients in the active group had become responders .", "sentence_id": 12}
+{"abstract_id": "25054836", "label": "results", "text": "Of the @ sham-GVC patients who later received active GVC , @ responded by post-GVC month @ .", "sentence_id": 13}
+{"abstract_id": "25054836", "label": "results", "text": "The most serious adverse event was an asymptomatic radiation-induced cyst in @ patient .", "sentence_id": 14}
+{"abstract_id": "25054836", "label": "conclusions", "text": "Gamma ventral capsulotomy benefitted patients with otherwise intractable OCD and thus appears to be an alternative to deep-brain stimulation in selected cases .", "sentence_id": 15}
+{"abstract_id": "25054836", "label": "conclusions", "text": "Given the risks inherent in any psychiatric neurosurgery , such procedures should be conducted at specialized centers .", "sentence_id": 16}
+{"abstract_id": "26065986", "label": "background", "text": "Vitamin K-dependent factors protect against vascular and renovascular calcification , and vitamin K antagonists may be associated with a decreased glomerular filtration rate ( GFR ) .", "sentence_id": 0}
+{"abstract_id": "26065986", "label": "objective", "text": "This study analyzed changes in GFR during long-term treatment with warfarin or dabigatran etexilate ( DE ) in patients enrolled in the RE-LY ( Randomized Evaluation of Long Term Anticoagulation Therapy ) trial .", "sentence_id": 1}
+{"abstract_id": "26065986", "label": "methods", "text": "Of the @,@ patients in the RE-LY study randomized to receive DE ( @ mg or @ mg twice daily ) or warfarin , @,@ patients with atrial fibrillation had creatinine values measured at baseline and at least @ follow-up visit .", "sentence_id": 2}
+{"abstract_id": "26065986", "label": "methods", "text": "Changes in GFR for up to @ months were evaluated .", "sentence_id": 3}
+{"abstract_id": "26065986", "label": "results", "text": "GFR declined in all treatment groups .", "sentence_id": 4}
+{"abstract_id": "26065986", "label": "results", "text": "After an average of @ months , the mean SE decline in GFR was significantly greater with warfarin ( -@ @ ml/min ) compared with DE @ mg ( -@ @ ml/min ; p = @ vs. warfarin ) and DE @ mg ( -@ @ ml/min ; p = @ vs. warfarin ) .", "sentence_id": 5}
+{"abstract_id": "26065986", "label": "results", "text": "A decrease in GFR > @ % was less likely with DE @ mg ( hazard ratio : @ -LSB- @ % confidence interval : @ to @ -RSB- ; p = @ ) or DE @ mg ( hazard ratio : @ -LSB- @ % confidence interval : @ to @ -RSB- ; p = @ ) than with warfarin in the observation period > @ months .", "sentence_id": 6}
+{"abstract_id": "26065986", "label": "results", "text": "Patients with poor international normalized ratio control ( i.e. , time in therapeutic range < @ % ) exhibited a faster decline in GFR .", "sentence_id": 7}
+{"abstract_id": "26065986", "label": "results", "text": "A more pronounced decline in GFR was associated with previous warfarin use and with the presence of diabetes .", "sentence_id": 8}
+{"abstract_id": "26065986", "label": "conclusions", "text": "Patients with atrial fibrillation receiving oral anticoagulation exhibited a decline in renal function that was greater in those taking warfarin versus DE , and it was amplified by diabetes and previous vitamin K antagonist use .", "sentence_id": 9}
+{"abstract_id": "26065986", "label": "conclusions", "text": "( Randomized Evaluation of Long Term Anticoagulant Therapy -LSB- RE-LY -RSB- With Dabigatran Etexilate ; NCT@ ) .", "sentence_id": 10}
+{"abstract_id": "25426808", "label": "objective", "text": "Combination antiretroviral therapy ( ART ) is now the global standard for HIV-infected pregnant and breastfeeding women at all CD@ cell counts .", "sentence_id": 0}
+{"abstract_id": "25426808", "label": "objective", "text": "We compared the efficacy and safety of an efavirenz versus lopinavir/ritonavir regimen for HIV-infected pregnant women initiating ART in rural Uganda .", "sentence_id": 1}
+{"abstract_id": "25426808", "label": "methods", "text": "Randomized clinical trial .", "sentence_id": 2}
+{"abstract_id": "25426808", "label": "methods", "text": "We performed a planned secondary analysis comparing viral load suppression ( HIV-@ RNA @ copies/ml ) , safety , and HIV transmission to infants in a trial designed to test the hypothesis that lopinavir/ritonavir versus efavirenz-based ART would reduce placental malaria ( PROMOTE , ClinicalTrials.gov , NCT@ ) .", "sentence_id": 3}
+{"abstract_id": "25426808", "label": "methods", "text": "HIV-infected , ART-naive pregnant women at @-@ weeks gestation and any CD@ cell count were randomized .", "sentence_id": 4}
+{"abstract_id": "25426808", "label": "methods", "text": "ART was provided and participants were counseled to breastfeed for @ year postpartum .", "sentence_id": 5}
+{"abstract_id": "25426808", "label": "results", "text": "The median age of the @ study participants was @ years ; median CD@ cell count was @ cells/l .", "sentence_id": 6}
+{"abstract_id": "25426808", "label": "results", "text": "At delivery , virologic suppression was @ % in the efavirenz arm and @ % in the lopinavir/ritonavir arm ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25426808", "label": "results", "text": "At @ weeks postpartum , @ % of women on efavirenz and @ % on lopinavir/ritonavir had viral suppression ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25426808", "label": "results", "text": "Grade @ or @ gastrointestinal adverse events were higher among women on lopinavir/ritonavir versus efavirenz .", "sentence_id": 9}
+{"abstract_id": "25426808", "label": "results", "text": "Only two infants acquired HIV ( both in the lopinavir/ritonavir arm ) , and HIV-free infant survival was similar between study arms : @ % ( lopinavir/ritonavir ) versus @ % ( efavirenz ) ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25426808", "label": "conclusions", "text": "Virologic suppression at delivery was higher with an efavirenz versus lopinavir/ritonavir-based regimen .", "sentence_id": 11}
+{"abstract_id": "25426808", "label": "conclusions", "text": "However , women in both arms achieved high levels of virologic suppression through @ year postpartum and the risk of transmission to infants was low .", "sentence_id": 12}
+{"abstract_id": "24699939", "label": "objective", "text": "The safety and efficacy of sirukumab , an anti-interleukin-@ ( IL-@ ) monoclonal antibody , were evaluated in a @-part , placebo-controlled phase II study of patients with active rheumatoid arthritis ( RA ) despite methotrexate therapy .", "sentence_id": 0}
+{"abstract_id": "24699939", "label": "methods", "text": "In Part A ( proof-of-concept ) , @ patients were randomised to placebo or sirukumab @mg every @weeks ( q@w ) through week @ , with crossover treatment during weeks @-@ .", "sentence_id": 1}
+{"abstract_id": "24699939", "label": "methods", "text": "In Part B ( dose finding ) , @ patients were randomised to sirukumab ( @mg q@w , @mg q@w , @mg q@w , or @mg q@w ) through week @ , or placebo through week @ with crossover to sirukumab @mg q@w ( weeks @-@ ) .", "sentence_id": 2}
+{"abstract_id": "24699939", "label": "methods", "text": "The proportion of patients with an American College of Rheumatology @ ( ACR@ ) response and the change from baseline in the @-joint count disease activity score using C-reactive protein ( DAS@-CRP ) were determined .", "sentence_id": 3}
+{"abstract_id": "24699939", "label": "methods", "text": "Safety was evaluated through week @ in both parts .", "sentence_id": 4}
+{"abstract_id": "24699939", "label": "results", "text": "The primary endpoint ( ACR@ at week @ in Part B ) was achieved only with sirukumab @mg q@w versus placebo ( @ % vs @ % ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24699939", "label": "results", "text": "Greater improvements in mean DAS@-CRP at week @ were observed with sirukumab @mg q@w versus placebo in Parts A ( @ vs @ , p < @ ) and B ( @ vs @ ; p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24699939", "label": "results", "text": "The incidence of adverse events ( AEs ) was similar for sirukumab-treated and placebo-treated patients through week @ in Part A ( @ % and @ % , respectively ) and B ( @ % and @ % , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24699939", "label": "results", "text": "Infections were the most common type of AE ; one death occurred ( Part B , sirukumab @mg q@w , brain aneurysm ) .", "sentence_id": 8}
+{"abstract_id": "24699939", "label": "conclusions", "text": "Sirukumab-treated patients experienced improvements in the signs/symptoms of RA .", "sentence_id": 9}
+{"abstract_id": "24699939", "label": "conclusions", "text": "Safety results through @weeks were consistent with other IL-@ inhibitors .", "sentence_id": 10}
+{"abstract_id": "24436355", "label": "objective", "text": "To evaluate the validity of the Yo-Yo Intermittent Recovery Test Level @ ( YYIR@ ) for the direct assessment and the indirect estimation of maximal oxygen consumption ( VO@max ) in female soccer players compared with a maximal laboratory treadmill test ( LTT ) .", "sentence_id": 0}
+{"abstract_id": "24436355", "label": "methods", "text": "Eighteen female soccer players ( @ @ y , @ @ cm , @ @ kg ; mean SD ) completed an LTT and a YYIR@ in random order ( @ wk apart ) .", "sentence_id": 1}
+{"abstract_id": "24436355", "label": "methods", "text": "Their VO@max was directly measured via portable spirometry during both tests and indirectly estimated from a published non-gender-specific formula ( YYIR@-F@ ) .", "sentence_id": 2}
+{"abstract_id": "24436355", "label": "results", "text": "The measured VO@max values in LTT and YYIR@ were @ @ and @ @ mL kg-@ min-@ , respectively , while the estimated VO@max values from YYIR@-F@ corresponded to @ @ mL kg-@ min-@ .", "sentence_id": 3}
+{"abstract_id": "24436355", "label": "results", "text": "Large positive correlations between the VO@max values from YYIR@ and LTT ( r = @ , P < @ , @ % confidence interval = @ -@ ) and YYIR@-F@ and LTT ( r = @ , P = @ , @ -@ ) were found .", "sentence_id": 4}
+{"abstract_id": "24436355", "label": "results", "text": "However , the YYIR@ significantly underestimated players ' VO@max by @ % compared with LTT ( P < @ ) with Bland-Altman @ % limits of agreement ranging from -@ % to @ % .", "sentence_id": 5}
+{"abstract_id": "24436355", "label": "results", "text": "A significant underestimation from the YYIR@-F@ ( P < @ ) was also identified ( @ % with Bland-Altman @ % limits of agreement ranging from -@ % to -@ % ) .", "sentence_id": 6}
+{"abstract_id": "24436355", "label": "conclusions", "text": "The YYIR@ and YYIR@-F@ are not accurate methods for the direct assessment or indirect estimation of VO@max in female soccer players .", "sentence_id": 7}
+{"abstract_id": "24436355", "label": "conclusions", "text": "The YYIR@-F@ lacks gender specificity , which might have been the reason for its larger error .", "sentence_id": 8}
+{"abstract_id": "24622415", "label": "background", "text": "An improper balance of regulatory/effector T ( Treg/Teff ) cells is central to the development of autoimmune diseases , including type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24622415", "label": "background", "text": "We previously showed that low-dose interleukin @ ( IL@ ) induced Treg cell expansion and activation and clinical improvement in patients with hepatitis-C-virus-induced vasculitis .", "sentence_id": 1}
+{"abstract_id": "24622415", "label": "background", "text": "We aimed to establish which low doses of IL@ would be safe and induce Treg cells in patients with type @ diabetes , considering that : ( @ ) type @ diabetes might be linked to alteration of the IL@/IL@R activation pathway ; ( @ ) activation of pathogenic Teff cells by IL@ could exacerbate disease ; and ( @ ) the safety of low-dose IL@ is not known in type @ diabetes .", "sentence_id": 2}
+{"abstract_id": "24622415", "label": "methods", "text": "This was a single-centre phase @/@ study .", "sentence_id": 3}
+{"abstract_id": "24622415", "label": "methods", "text": "@ adult patients ( @-@ years ) with established insulin-dependent type @ diabetes and at least one diabetes-related autoantibody were enrolled and randomly assigned ( in a @:@:@:@ ratio , by computer-generated randomisation list , with block size four ) to placebo or IL@ at @ MIU/day , @ MIU/day , or @ MIU/day for a @-day course and were followed up for @ days .", "sentence_id": 4}
+{"abstract_id": "24622415", "label": "methods", "text": "All investigators and participants were masked to assignment .", "sentence_id": 5}
+{"abstract_id": "24622415", "label": "methods", "text": "The primary outcome was change in Treg cells , measured by flow cytometry , and expressed as a percentage of CD@ + T cells , from day @ to day @ .", "sentence_id": 6}
+{"abstract_id": "24622415", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "24622415", "label": "results", "text": "Six patients were assigned to each group between June @ , @ , and Feb @ , @ .", "sentence_id": 8}
+{"abstract_id": "24622415", "label": "results", "text": "IL@ was well tolerated at all doses , with no serious adverse events .", "sentence_id": 9}
+{"abstract_id": "24622415", "label": "results", "text": "However , there was a dose-response association for non-serious adverse events during the treatment phase ( days @-@ ) ; one patient in the placebo group , three patients in the @ MIU group , five patients in the @ MIU group , and six patients in the @ MIU group had non-serious adverse events .", "sentence_id": 10}
+{"abstract_id": "24622415", "label": "results", "text": "The most common adverse events in the treatment phase were injection-site reaction ( no patients with placebo vs three patients with @ MIU and @ MIU vs two patients with @ MIU ) and influenza-like syndrome ( no patients with placebo vs one patient with @ MIU and @ MIU vs four patients with @ MIU ) .", "sentence_id": 11}
+{"abstract_id": "24622415", "label": "results", "text": "After the treatment phase , adverse events did not differ between groups .", "sentence_id": 12}
+{"abstract_id": "24622415", "label": "results", "text": "IL@ did not induce deleterious changes in glucose-metabolism variables .", "sentence_id": 13}
+{"abstract_id": "24622415", "label": "results", "text": "IL@ induced a dose-dependent increase in the proportion of Treg cells , significant at all doses compared with placebo ( placebo mean increase @ % -LSB- SD @ -RSB- ; @ MIU @ % -LSB- @ -RSB- , p = @ ; @ MIU @ % -LSB- @ -RSB- , p = @ ; @ MIU @ % -LSB- @ -RSB- p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24622415", "label": "conclusions", "text": "We have defined a well-tolerated and immunologically effective dose range of IL@ for application to type @ diabetes therapy and prevention , which could be relevant to other disorders in which a Treg cell increase would be desirable .", "sentence_id": 15}
+{"abstract_id": "24754230", "label": "objective", "text": "The objective of this research was to compare the effects of different causal attributions for overweight and obesity , among individuals with overweight and obesity , on weight-related beliefs , stigmatising attitudes and policy support .", "sentence_id": 0}
+{"abstract_id": "24754230", "label": "methods", "text": "In Study @ , an online sample of @ US adults rated the extent to which they believed various factors caused their own weight status .", "sentence_id": 1}
+{"abstract_id": "24754230", "label": "methods", "text": "In Study @ , @ US adults read one of three randomly assigned online passages attributing obesity to personal responsibility , biology , or the ` food environment . '", "sentence_id": 2}
+{"abstract_id": "24754230", "label": "methods", "text": "All participants in both studies were overweight or obese .", "sentence_id": 3}
+{"abstract_id": "24754230", "label": "methods", "text": "All participants reported beliefs about weight loss , weight-stigmatising attitudes , and support for obesity-related policies .", "sentence_id": 4}
+{"abstract_id": "24754230", "label": "results", "text": "In Study @ , biological attributions were associated with low weight-malleability beliefs and blame , high policy support , but high internalised weight bias .", "sentence_id": 5}
+{"abstract_id": "24754230", "label": "results", "text": "` Food environment ' attributions were not associated with any outcomes , while ` personal responsibility ' attributions were associated with high prejudice and blame .", "sentence_id": 6}
+{"abstract_id": "24754230", "label": "results", "text": "In Study @ , participants who received information about the food environment reported greater support for food-related policies and greater self-efficacy to lose weight .", "sentence_id": 7}
+{"abstract_id": "24754230", "label": "conclusions", "text": "Emphasising the role of the food environment in causing obesity may promote food policy support and health behaviours without imposing the negative consequences associated with other attributions .", "sentence_id": 8}
+{"abstract_id": "24694949", "label": "background", "text": "The aim of this study was to evaluate the impact of Quality and Outcomes Framework ( QOF ) , a major pay-for-performance programme in the United Kingdom , on prescribing of long-acting reversible contraceptives ( LARC ) in primary care .", "sentence_id": 0}
+{"abstract_id": "24694949", "label": "methods", "text": "Negative binomial interrupted time series analysis using practice level prescribing data from April @ to March @ .", "sentence_id": 1}
+{"abstract_id": "24694949", "label": "methods", "text": "The main outcome measure was the prescribing rate of long-acting reversible contraceptives ( LARC ) , including hormonal and non hormonal intrauterine devices and systems ( IUDs and IUSs ) , injectable contraceptives and hormonal implants .", "sentence_id": 2}
+{"abstract_id": "24694949", "label": "results", "text": "Prescribing rates of Long-Acting Reversible Contraception ( LARC ) were stable before the introduction of contraceptive targets to the QOF and increased afterwards by @ % annually ( rate ratios = @ , @ % CI = @ , @ ) .", "sentence_id": 3}
+{"abstract_id": "24694949", "label": "results", "text": "The increase in LARC prescribing was mainly driven by increases in injectables ( increased by @ % annually ) , which was the most commonly prescribed LARC method .", "sentence_id": 4}
+{"abstract_id": "24694949", "label": "results", "text": "Of other types of LARC , the QOF indicator was associated with a step increase of @ % in implant prescribing ( RR = @ , @ % CI = @ , @ ) .", "sentence_id": 5}
+{"abstract_id": "24694949", "label": "results", "text": "This change is equivalent to an additional @ thousand women being prescribed with LARC had QOF points not been introduced .", "sentence_id": 6}
+{"abstract_id": "24694949", "label": "conclusions", "text": "Pay for performance incentives for contraceptive counselling in primary care with women seeking contraceptive advice has increased uptake of LARC methods .", "sentence_id": 7}
+{"abstract_id": "24514431", "label": "objective", "text": "To investigate the efficacy and safety of sedation with dexmedetomidine in upper gastrointestinal endoscopy .", "sentence_id": 0}
+{"abstract_id": "24514431", "label": "methods", "text": "Patients with ASA physical status I-II undergoing elective upper gastrointestinal endoscopy were randomly allocated to receive dexmedetomidine or midazolam for conscious sedation .", "sentence_id": 1}
+{"abstract_id": "24514431", "label": "methods", "text": "Continuous peripheral oxygen saturation ( SpO@ ) , heart rate , mean arterial pressure ( MAP ) , Ramsay Sedation Scale ( RSS ) and numeric rating scale pain scores were recorded before , during and after the procedure .", "sentence_id": 2}
+{"abstract_id": "24514431", "label": "methods", "text": "Patients completed a post-procedure satisfaction questionnaire .", "sentence_id": 3}
+{"abstract_id": "24514431", "label": "results", "text": "Patients in the midazolam group ( n = @ ) experienced a significant decrease in MAP during sedation compared with pre-sedation values .", "sentence_id": 4}
+{"abstract_id": "24514431", "label": "results", "text": "Patients in the dexmedetomidine group ( n = @ ) had significantly higher SpO@ and RSS scores during sedation than those in the midazolam group .", "sentence_id": 5}
+{"abstract_id": "24514431", "label": "results", "text": "Overall satisfaction was higher in the dexmedetomidine group than the midazolam group .", "sentence_id": 6}
+{"abstract_id": "24514431", "label": "results", "text": "There were no clinically significant complications in either group .", "sentence_id": 7}
+{"abstract_id": "24514431", "label": "conclusions", "text": "Dexmedetomidine has a good safety profile and is an effective sedative for use in upper gastrointestinal endoscopy .", "sentence_id": 8}
+{"abstract_id": "24524399", "label": "objective", "text": "To evaluate the sedation and analgesia power and security of sufentanil in intensive care unit ( ICU ) , and to compare the effect with fentanyl .", "sentence_id": 0}
+{"abstract_id": "24524399", "label": "methods", "text": "A multicenter randomized controlled trial was conducted .", "sentence_id": 1}
+{"abstract_id": "24524399", "label": "methods", "text": "Critical adult patients in ICU from @ hospitals in Henan Province from June @ to January @ who needed analgesia based sedation were enrolled .", "sentence_id": 2}
+{"abstract_id": "24524399", "label": "methods", "text": "These patients were randomly divided into two groups with @ cases in each group using the envelope method according to the hospital number and time sequence number of inclusion .", "sentence_id": 3}
+{"abstract_id": "24524399", "label": "methods", "text": "Exclusion criteria included the time of analgesia duration < @ hours and who were under continuous renal replacement therapy ( CRRT ) treatment during analgesia .", "sentence_id": 4}
+{"abstract_id": "24524399", "label": "methods", "text": "@ cases were enrolled finally , and there were @ cases in sufentanil group and @ in fentanyl group .", "sentence_id": 5}
+{"abstract_id": "24524399", "label": "methods", "text": "Before using the drug , there was no statistically significant difference in age , body weight , acute physiology and chronic health evaluation II ( APACHEII ) score , Glasgow coma scale ( GCS ) between sufentanil group and fentanyl group , and were comparable .", "sentence_id": 6}
+{"abstract_id": "24524399", "label": "methods", "text": "The goal of analgesia was faces pain scale ( FPS ) @ .", "sentence_id": 7}
+{"abstract_id": "24524399", "label": "methods", "text": "If the dosage of sufentanil and fentanyl exceeded the upper limited dose ( sufentanil @ gkg ( -@ ) h ( -@ ) , fentanyl @ gkg ( -@ ) h ( -@ ) ) but FPS could not meet ( still > @ ) , and maintained the upper limited doses of sufentanil and fentanyl and added midazolam , and FPS@ or Ramsay @ could meet the standard .", "sentence_id": 8}
+{"abstract_id": "24524399", "label": "methods", "text": "The analgesia duration of all cases was @-@ hours .", "sentence_id": 9}
+{"abstract_id": "24524399", "label": "methods", "text": "Related data were collected for statistical analysis .", "sentence_id": 10}
+{"abstract_id": "24524399", "label": "results", "text": "( @ ) Compared with the data before the analgesia , the mean arterial pressure ( MAP ) of sufentanil analgesia after analgesia at different time points were significantly decreased ( F = @ , P < @ ) and closed to the normal level , FPS at different time point score were decreased significantly after analgesia ( F = @ , P < @ ) , and the changes in pulse oxygen saturation ( SpO ( @ ) ) , respiratory rate and pulse were not found .", "sentence_id": 11}
+{"abstract_id": "24524399", "label": "results", "text": "( @ ) Compared with before the analgesia , the white blood cell count ( WBC ) , neutrophil percentage ( N ) , platelet count ( PLT ) , aspartate transaminase ( AST ) , creatinine ( Cr ) , arterial partial pressure of carbon dioxide ( PaCO ( @ ) ) , blood lactic acid , blood sugar , C-reactive protein ( CRP ) were markedly reduced after sufentanil analgesia ( WBC : @ @ @ ( @ ) / L vs. @ @ ( @ ) / L , F = @ , P < @ ; N : @ @ vs. @ @ , F = @ , P = @ ; PLT : @ @ @ ( @ ) / L vs. @ @ ( @ ) / L , F = @ , P = @ ; AST : @ @ U/L vs. @ @ U/L , F = @ , P = @ ; Cr : @ @ mol/L vs. @ @ mol/L , F = @ , P < @ ; PaCO ( @ ) : @ @ mmHg vs. @ @ mmHg , F = @ , P = @ ; blood lactic acid : @ @ mmol/L vs. @ @ mmol/L , F = @ , P = @ ; blood sugar : @ @ mmol/L vs. @ @ mmol/L , F = @ , P = @ ; CRP : @ @ mg/L vs. @ @ mg/L , F = @ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24524399", "label": "results", "text": "But there were no statistically significant differences in red blood cell count ( RBC ) , prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , thrombin time ( TT ) , alanine aminotransferase ( ALT ) , total bilirubin ( TBil ) , albumin ( ALB ) , total protein ( TP ) blood urea nitrogen ( BUN ) , and arterial partial pressure of oxygen ( PaO ( @ ) ) before and after sufentanil analgesia ( all P > @ ) .", "sentence_id": 13}
+{"abstract_id": "24524399", "label": "results", "text": "( @ ) There was no statistically significant difference in effectiveness of sufentanil and five times dose of fentanyl ( P > @ ) .", "sentence_id": 14}
+{"abstract_id": "24524399", "label": "results", "text": "There was no statistically significant difference in the proportion of sedative drugs midazolam usage -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , ( @ ) = @ , P = @ -RSB- and the rate of analgesia success -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , ( @ ) = @ , P = @ -RSB- and analgesia success -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , ( @ ) = @ , P = @ -RSB- between sufentanil and fentanyl group .", "sentence_id": 15}
+{"abstract_id": "24524399", "label": "results", "text": "( @ ) Comparison of adverse reactions : the incidence of hypotension in sufentanil group was significantly lower than that in fentanyl group -LSB- @ % ( @/@ ) vs. @ % ( @/@ ) , ( @ ) = @ , P = @ -RSB- , and other common adverse reactions , such as respiratory depression/pause , nausea/vomiting and dizziness , pruritus , allergy , slow heart beat ( bradycardia ) and metabolic reactions had no statistically significant difference .", "sentence_id": 16}
+{"abstract_id": "24524399", "label": "results", "text": "Addiction or tetanus of skeletal muscles was not found in both groups .", "sentence_id": 17}
+{"abstract_id": "24524399", "label": "conclusions", "text": "Compared with fentanyl , the analgesia efficacy of sufentanil is stronger .", "sentence_id": 18}
+{"abstract_id": "24524399", "label": "conclusions", "text": "Sufentanil has less physiological interference and lower incidence of adverse reactions for ICU patients .", "sentence_id": 19}
+{"abstract_id": "24447332", "label": "background", "text": "After @/@/@ , most FDNY workers had persistent lung function decline but some exposed workers recovered .", "sentence_id": 0}
+{"abstract_id": "24447332", "label": "background", "text": "We hypothesized that the protease/anti-protease balance in serum soon after exposure predicts subsequent recovery .", "sentence_id": 1}
+{"abstract_id": "24447332", "label": "methods", "text": "We performed a nested case-control study measuring biomarkers in serum drawn before @/@ and subsequent forced expiratory volume at one second ( FEV@ ) on repeat spirometry before @/@ .", "sentence_id": 2}
+{"abstract_id": "24447332", "label": "methods", "text": "Serum was assayed for matrix metalloproteinases ( MMP-@ ,@,@,@,@,@,@ and @ ) and tissue inhibitors of metalloproteinases ( TIMP-@ ,@,@,@ ) .", "sentence_id": 3}
+{"abstract_id": "24447332", "label": "methods", "text": "The representative sub-cohort defined analyte distribution and a concentration above @th percentile defined elevated biomarker expression .", "sentence_id": 4}
+{"abstract_id": "24447332", "label": "methods", "text": "An FEV@ one standard deviation above the mean defined resistance to airway injury .", "sentence_id": 5}
+{"abstract_id": "24447332", "label": "methods", "text": "Logistic regression was adjusted for pre-@ / @ FEV@ , BMI , age and exposure intensity modeled the association between elevated biomarker expression and above average FEV@ .", "sentence_id": 6}
+{"abstract_id": "24447332", "label": "results", "text": "FEV@ in cases and controls declined @ % of after @/@/@ .", "sentence_id": 7}
+{"abstract_id": "24447332", "label": "results", "text": "Cases subsequently returned to @ % of their pre-exposure FEV@ while decline persisted in controls .", "sentence_id": 8}
+{"abstract_id": "24447332", "label": "results", "text": "Elevated TIMP-@ and MMP-@ increased the odds of resistance by @ and @ fold while elevated MMP-@ decreased it by @ fold .", "sentence_id": 9}
+{"abstract_id": "24447332", "label": "conclusions", "text": "Resistant cases displayed healing , returning to @ % of pre-exposure values .", "sentence_id": 10}
+{"abstract_id": "24447332", "label": "conclusions", "text": "High TIMP-@ and MMP-@ predict healing .", "sentence_id": 11}
+{"abstract_id": "24447332", "label": "conclusions", "text": "MMP/TIMP balance reflects independent pathways to airway injury and repair after WTC exposure .", "sentence_id": 12}
+{"abstract_id": "24387842", "label": "background", "text": "Postoperative shivering is a frequent complication of surgery in developing countries and there is no satisfying method to treat it , letalone to cure it .", "sentence_id": 0}
+{"abstract_id": "24387842", "label": "background", "text": "We studied whether intravenous amino acid ( AA ) infusion can cure postoperative shivering in the postanesthesia care unit .", "sentence_id": 1}
+{"abstract_id": "24387842", "label": "methods", "text": "Sixty postanesthesia care unit patients with shivering grade @ or higher and tympanic temperature < @C received randomly either infusion of Novamin @ AAs ( @ mL/kg/h ) , pethidine ( @ mg/kg ) , or tramadol ( @ mg/kg ) .", "sentence_id": 2}
+{"abstract_id": "24387842", "label": "methods", "text": "Tympanic temperature , shivering grade , and thermal comfort were assessed every @min for @min .", "sentence_id": 3}
+{"abstract_id": "24387842", "label": "methods", "text": "Blood glucose and lactic acid concentrations were measured before and after treatment .", "sentence_id": 4}
+{"abstract_id": "24387842", "label": "methods", "text": "Postoperative nausea and vomiting were also recorded .", "sentence_id": 5}
+{"abstract_id": "24387842", "label": "results", "text": "Shivering stopped within @min in the pethidine and tramadol groups versus @ % stopped within @min in AA group .", "sentence_id": 6}
+{"abstract_id": "24387842", "label": "results", "text": "There were five cases of reshivering in the tramadol group versus none in the AA or pethidine groups .", "sentence_id": 7}
+{"abstract_id": "24387842", "label": "results", "text": "Tympanic temperature increased slowly in all patients but increased significantly faster in the AA group .", "sentence_id": 8}
+{"abstract_id": "24387842", "label": "results", "text": "Thermal comfort improved significantly faster in the AA group versus the other two groups , thermal comfort was significantly higher in the tramadol versus the pethidine group @min .", "sentence_id": 9}
+{"abstract_id": "24387842", "label": "results", "text": "Blood glucose concentration in AA group increased to @ mg/dL .", "sentence_id": 10}
+{"abstract_id": "24387842", "label": "results", "text": "There were some cases of nausea and vomiting in pethidine and tramadol groups but none in the AA group .", "sentence_id": 11}
+{"abstract_id": "24387842", "label": "conclusions", "text": "Novamin infusion can stop postoperative shivering and alleviates hypothermia and improves thermal comfort more effectively than tramadol and pethidine with less nausea and vomiting and causes a clinically acceptable blood glucose increase with no reshivering episodes .", "sentence_id": 12}
+{"abstract_id": "25617561", "label": "background", "text": "Inflammation is one of the main contributory factors to the etiopathogenesis of multiple sclerosis ( MS ) .", "sentence_id": 0}
+{"abstract_id": "25617561", "label": "background", "text": "Dietary interventions with Lipia citriadora ( lemon verbena ) extracts have been proved to be effective in the prevention of inflammatory diseases .", "sentence_id": 1}
+{"abstract_id": "25617561", "label": "objective", "text": "The aim of this study is to evaluate the effect of lemon verbena supplementation in pro- and anti- inflammatory serum biomarkers of patients with different clinical subtypes of multiple sclerosis .", "sentence_id": 2}
+{"abstract_id": "25617561", "label": "methods", "text": "The effect of lemon verbena supplementation ( @ % w/w verbascoside ) was evaluated in a randomized , double-blinded placebo-controlled study with @ participants classified in relapsing-remitting ( n = @ ) , primary progressive ( n = @ ) and secondary progressive ( n = @ ) MS presentations .", "sentence_id": 3}
+{"abstract_id": "25617561", "label": "methods", "text": "Serum cytokine and C reactive protein levels were assessed in intervention and control groups for each MS clinical subtype after @ days of dietary supplementation .", "sentence_id": 4}
+{"abstract_id": "25617561", "label": "results", "text": "Serum levels of C reactive protein and @ cytokines / inflammatory ( IFN - , IL-@ , IL-@ , IL-@ , TNF - , TGF - , IL-@ and IL-@ ) markers were studied .", "sentence_id": 5}
+{"abstract_id": "25617561", "label": "results", "text": "Secondary progressive MS - supplemented patients showed C reactive protein concentrations significantly lower compared to the placebo group ( p.", "sentence_id": 6}
+{"abstract_id": "25562774", "label": "background", "text": "Most diabetic and hypertensive patients , principally the elderly , do not achieve adequate disease control and consume @ % -@ % of annual health care budgets .", "sentence_id": 0}
+{"abstract_id": "25562774", "label": "background", "text": "Previous studies verified that pharmaceutical care is useful for achieving adequate disease control in diabetes and hypertension .", "sentence_id": 1}
+{"abstract_id": "25562774", "label": "objective", "text": "To evaluate the economic cost and the incremental cost-effectiveness ratio ( ICER ) per quality-adjusted life-year ( QALY ) of pharmaceutical care in the management of diabetes and hypertension in elderly patients in a primary public health care system in a developing country .", "sentence_id": 2}
+{"abstract_id": "25562774", "label": "methods", "text": "A @-month randomized controlled clinical trial was performed with @ patients who were divided into a control group ( n = @ ) and an intervention group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25562774", "label": "methods", "text": "The control group received the usual care offered by the Primary Health Care Unit ( medical and nurse consultations ) .", "sentence_id": 4}
+{"abstract_id": "25562774", "label": "methods", "text": "The intervention group received the usual care plus a pharmaceutical care intervention .", "sentence_id": 5}
+{"abstract_id": "25562774", "label": "methods", "text": "The intervention and control groups were compared with regard to the direct costs of health services ( i.e. , general practitioner , specialist , nurse , and pharmacist appointments ; emergency room visits ; and drug therapy costs ) and the ICER per QALY .", "sentence_id": 6}
+{"abstract_id": "25562774", "label": "methods", "text": "These evaluations used the health system perspective .", "sentence_id": 7}
+{"abstract_id": "25562774", "label": "results", "text": "No statistically significant difference was found between the intervention and control groups in total direct health care costs ( $ @ $ @ per patient vs. $ @ $ @ per patient , respectively ; P = @ ) ; pharmaceutical care added incremental costs of $ @ ( $ @ ) per patient .", "sentence_id": 8}
+{"abstract_id": "25562774", "label": "results", "text": "The ICER per QALY was $ @ ( @ % CI = $ @ - $ @ ; monetary amounts are given in U.S. dollars ) .", "sentence_id": 9}
+{"abstract_id": "25562774", "label": "results", "text": "Every clinical parameter evaluated improved for the pharmaceutical care group , whereas these clinical parameters remained unchanged in the usual care group .", "sentence_id": 10}
+{"abstract_id": "25562774", "label": "results", "text": "The difference in differences ( DID ) tests indicated that for each clinical parameter , the patients in the intervention group improved more from pre to post than the control group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25562774", "label": "conclusions", "text": "While pharmaceutical care did not significantly increase total direct health care costs , significantly improved health outcomes were seen .", "sentence_id": 12}
+{"abstract_id": "25562774", "label": "conclusions", "text": "The mean ICER per QALY gained suggests a favorable cost-effectiveness .", "sentence_id": 13}
+{"abstract_id": "25209306", "label": "background", "text": "One important public health issue associated with opioid use today is the risk of hepatitis C ( HCV ) infection .", "sentence_id": 0}
+{"abstract_id": "25209306", "label": "background", "text": "Although methadone maintenance may help to decrease HCV-related risk practices , HCV risk behaviors persist and are strongly associated with specific substance use patterns , mental status and social context .", "sentence_id": 1}
+{"abstract_id": "25209306", "label": "background", "text": "The ANRS-Methaville study gave us the opportunity to better disentangle the different relationships between these various factors and HCV risk practices .", "sentence_id": 2}
+{"abstract_id": "25209306", "label": "methods", "text": "The ANRS-Methaville multisite randomized trial was designed to assess the feasibility of initiating methadone in primary care by comparing it with methadone initiation in specialized centers .", "sentence_id": 3}
+{"abstract_id": "25209306", "label": "methods", "text": "This study recruited @ participants initiating methadone maintenance and followed up for @months .", "sentence_id": 4}
+{"abstract_id": "25209306", "label": "methods", "text": "Longitudinal data from this trial was used to acquire a greater understanding of HCV risk practices and their pattern of correlates in this population .", "sentence_id": 5}
+{"abstract_id": "25209306", "label": "methods", "text": "We selected @ patients who had data on HCV risk practices at M@ and M@ , accounting for @ visits .", "sentence_id": 6}
+{"abstract_id": "25209306", "label": "methods", "text": "HCV risk practices were defined as follows : sharing needles or syringes , sharing drug paraphernalia , getting a tattoo or having a piercing in a non-professional context , sharing toiletry items .", "sentence_id": 7}
+{"abstract_id": "25209306", "label": "methods", "text": "To identify factors associated with HCV risk practices , we performed a mixed logistic regression analysis .", "sentence_id": 8}
+{"abstract_id": "25209306", "label": "results", "text": "HCV risk practices were reported by @ % and @ % of participants at baseline and M@ , respectively .", "sentence_id": 9}
+{"abstract_id": "25209306", "label": "results", "text": "After adjustment for age , cocaine use and alcohol dependence as well as suicidal risk , living in a couple with a non-drug user and in a couple with a drug user were both independent predictors of HCV risk practices ( OR -LSB- CI@ % -RSB- = @ -LSB- @-@ @ -RSB- ; OR -LSB- CI@ % -RSB- = @ -LSB- @-@ @ -RSB- , respectively ) .", "sentence_id": 10}
+{"abstract_id": "25209306", "label": "conclusions", "text": "Identifying individuals at risk of HCV transmission during methadone treatment such as stimulant users , alcohol dependent individuals , and those at suicidal risk is necessary to optimize response to treatment .", "sentence_id": 11}
+{"abstract_id": "25209306", "label": "conclusions", "text": "Innovative prevention approaches tailored to couples are also urgently needed and could decrease HCV-risk in this population .", "sentence_id": 12}
+{"abstract_id": "25209306", "label": "conclusions", "text": "The trial is registered with the French Agency of Pharmaceutical Products ( ANSM ) under the number @-A@-@ , the European Union Drug Regulating Authorities Clinical Trials .", "sentence_id": 13}
+{"abstract_id": "25209306", "label": "conclusions", "text": "Number Eudract @-@-@ , the ClinicalTrials.gov Identifier : NCT@ and the International Standard Randomised Controlled Trial Number Register ISRCTN@ .", "sentence_id": 14}
+{"abstract_id": "26374429", "label": "background", "text": "National Surgical Adjuvant Breast and Bowel Project R-@ was designed to determine whether the oral fluoropyrimidine capecitabine could be substituted for continuous infusion @-FU in the curative setting of stage II/III rectal cancer during neoadjuvant radiation therapy and whether the addition of oxaliplatin could further enhance the activity of fluoropyrimidine-sensitized radiation .", "sentence_id": 0}
+{"abstract_id": "26374429", "label": "methods", "text": "Patients with clinical stage II or III rectal cancer undergoing preoperative radiation were randomly assigned to one of four chemotherapy regimens in a @x@ design : CVI @-FU or oral capecitabine with or without oxaliplatin .", "sentence_id": 1}
+{"abstract_id": "26374429", "label": "methods", "text": "The primary endpoint was local-regional tumor control .", "sentence_id": 2}
+{"abstract_id": "26374429", "label": "methods", "text": "Time-to-event endpoint distributions were estimated using the Kaplan-Meier method .", "sentence_id": 3}
+{"abstract_id": "26374429", "label": "methods", "text": "Hazard ratios were estimated from Cox proportional hazard models .", "sentence_id": 4}
+{"abstract_id": "26374429", "label": "methods", "text": "All statistical tests were two-sided .", "sentence_id": 5}
+{"abstract_id": "26374429", "label": "results", "text": "Among @ randomized patients there were no statistically significant differences between regimens using @-FU vs capecitabine in three-year local-regional tumor event rates ( @ % vs @ % ) , @-year DFS ( @ % vs @ % ) , or @-year OS ( @ % vs @ % ) ; or for oxaliplatin vs no oxaliplatin for the three endpoints of local-regional events , DFS , and OS ( @ % vs @ % , @ % vs @ % , and @ % vs @ % ) .", "sentence_id": 6}
+{"abstract_id": "26374429", "label": "results", "text": "The addition of oxaliplatin was associated with statistically significantly more overall and grade @-@ diarrhea ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26374429", "label": "results", "text": "Three-year rates of local-regional recurrence among patients who underwent R@ resection ranged from @ to @ % depending on the study arm .", "sentence_id": 8}
+{"abstract_id": "26374429", "label": "conclusions", "text": "Continuous infusion @-FU produced outcomes for local-regional control , DFS , and OS similar to those obtained with oral capecitabine combined with radiation .", "sentence_id": 9}
+{"abstract_id": "26374429", "label": "conclusions", "text": "This study establishes capecitabine as a standard of care in the pre-operative rectal setting .", "sentence_id": 10}
+{"abstract_id": "26374429", "label": "conclusions", "text": "Oxaliplatin did not improve the local-regional failure rate , DFS , or OS for any patient risk group but did add considerable toxicity .", "sentence_id": 11}
+{"abstract_id": "24440105", "label": "objective", "text": "To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed using @-degree and @-degree aperture angled tips .", "sentence_id": 0}
+{"abstract_id": "24440105", "label": "methods", "text": "Maltepe University School of Medicine Department of Ophthalmology , Istanbul , Turkey .", "sentence_id": 1}
+{"abstract_id": "24440105", "label": "methods", "text": "Comparative case series .", "sentence_id": 2}
+{"abstract_id": "24440105", "label": "methods", "text": "Eyes were assigned to @ mm microcoaxial phacoemulsification using the torsional mode with a @-degree ( Group @ ) or @-degree ( Group @ ) aperture angled tip .", "sentence_id": 3}
+{"abstract_id": "24440105", "label": "methods", "text": "A quick-chop surgical technique was used .", "sentence_id": 4}
+{"abstract_id": "24440105", "label": "methods", "text": "The primary outcome measures were ultrasound time ( UST ) , cumulative dissipated energy ( CDE ) , longitudinal and torsional ultrasound ( US ) amplitudes , mean surgical time , mean balanced salt solution volume used , and mean central corneal thickness ( CCT ) changes .", "sentence_id": 5}
+{"abstract_id": "24440105", "label": "results", "text": "The mean UST , CDE , and longitudinal and torsional US amplitudes were @ seconds @ ( SD ) , @ @ , @ @ , and @ @ in Group @ and @ @ seconds , @ @ , @ @ , and @ @ in Group @ , respectively .", "sentence_id": 6}
+{"abstract_id": "24440105", "label": "results", "text": "The mean CDE and torsional amplitudes were significantly lower in Group @ ( P = @ and P = @ , respectively ) .", "sentence_id": 7}
+{"abstract_id": "24440105", "label": "results", "text": "The mean balanced salt solution volume was @ @ cc in Group @ and @ @ cc in Group @ ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24440105", "label": "results", "text": "The mean CCT change was @ @ m and @ @ m , respectively ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24440105", "label": "conclusions", "text": "Torsional phacoemulsification performed with a @-degree aperture angled tip provided more effective lens removal with a lower CDE and less CCT change than a @-degree aperture angled tip .", "sentence_id": 10}
+{"abstract_id": "24730623", "label": "objective", "text": "To evaluate the intra-operative and postoperative outcome of paediatric cataract surgery with primary posterior capsulotomy ( PPC ) and anterior vitrectomy using intra-operative preservative-free triamcinolone acetonide .", "sentence_id": 0}
+{"abstract_id": "24730623", "label": "methods", "text": "In this prospective , interventional case-control study , @ Children who underwent cataract surgery for both eyes were enrolled and their eyes were randomized into two groups .", "sentence_id": 1}
+{"abstract_id": "24730623", "label": "methods", "text": "Group A consists of @ eyes in which standard phacoaspiration with PPC with intracameral triamcinolone was used , and Group B consists of @ eyes in which triamcinolone were not used .", "sentence_id": 2}
+{"abstract_id": "24730623", "label": "methods", "text": "Intra-operative complications and postoperative outcome like intraocular pressure ( IOP ) , posterior synechiae , pigment deposits and posterior capsule opacification ( PCO ) were studied .", "sentence_id": 3}
+{"abstract_id": "24730623", "label": "results", "text": "In both groups , age range varied between @-@ years comprising @ males and two females .", "sentence_id": 4}
+{"abstract_id": "24730623", "label": "results", "text": "The mean postoperative IOP did not show any significant variation during @-month follow-up .", "sentence_id": 5}
+{"abstract_id": "24730623", "label": "results", "text": "In study group , all the @ eyes were quiet at @ weeks , while there was cellular reaction @ + in four eyes ( @ % ) and nil in @ eyes ( @ % ) at @ week in the control group ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24730623", "label": "results", "text": "Pigment deposits on IOL optic was seen in two eyes ( @ % ) of the study group while in control group , IOL deposits were present in @ eyes ( @ % ) ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24730623", "label": "results", "text": "Posterior capsule opacification was seen in two eyes ( @ % ) in control group at @ months while none occurred in study group .", "sentence_id": 8}
+{"abstract_id": "24730623", "label": "conclusions", "text": "Intra-operative use of preservative-free triamcinolone acetonide led to less anterior chamber inflammation and pigment deposits on IOL optic postoperatively compared to those eyes where it was not used .", "sentence_id": 9}
+{"abstract_id": "24944264", "label": "objective", "text": "To determine whether allopregnanolone ( AP ) may mediate seizure reduction in progesterone-treated women with epilepsy .", "sentence_id": 0}
+{"abstract_id": "24944264", "label": "methods", "text": "The NIH Progesterone Trial compared the efficacy of adjunctive cyclic natural progesterone therapy vs placebo treatment of intractable seizures in @ subjects , randomized @:@ to progesterone or placebo , stratified by catamenial vs noncatamenial designation .", "sentence_id": 1}
+{"abstract_id": "24944264", "label": "methods", "text": "Treatments were compared on proportions of @ % responders , and changes in seizure frequency from @ baseline to @ treatment cycles .", "sentence_id": 2}
+{"abstract_id": "24944264", "label": "methods", "text": "Serum AP levels were measured by radioimmunoassay from @ women with intractable focal-onset seizures who had baseline and treatment-phase midluteal serum samples drawn each cycle for hormone measurements .", "sentence_id": 3}
+{"abstract_id": "24944264", "label": "results", "text": "There was no significant correlation between percentage changes in AP levels and seizure frequencies from baseline to treatment for either the catamenial or noncatamenial stratum .", "sentence_id": 4}
+{"abstract_id": "24944264", "label": "results", "text": "There was a significant correlation for the subset of subjects who showed a significantly greater responder rate in the post hoc analysis of the trial , i.e. , subjects who had a @-fold or greater increase in average daily seizure frequency perimenstrually compared with the midfollicular and midluteal phases ( C@ @ : r = -@ , p = @ , and specifically for C@ @ progesterone-treated subjects -LSB- r = -@ , p = @ -RSB- , but not other groups -LSB- C@ @ placebo : r = -@ ; C@ < @ progesterone : r = @ ; C@ < @ placebo : r = @ ; p = not significant -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "24944264", "label": "conclusions", "text": "The findings support AP as a mediator of seizure reduction in progesterone-treated women who have a substantial level of perimenstrually exacerbated seizures .", "sentence_id": 6}
+{"abstract_id": "24728329", "label": "objective", "text": "To compare the relative bioavailability , safety and tolerability of oral methotrexate ( MTX ) and subcutaneous ( SC ) MTX administered via an auto-injector ( MTXAI ) in patients with rheumatoid arthritis ( RA ) .", "sentence_id": 0}
+{"abstract_id": "24728329", "label": "methods", "text": "In this randomised , multicenter , open-label , three-way crossover study , patients @years with adult RA undergoing treatment with MTX for @months were assigned to receive MTX @ , @ , @ and @mg weekly in a random sequence of three treatments : oral , SC into the abdomen and SC into the thigh .", "sentence_id": 1}
+{"abstract_id": "24728329", "label": "methods", "text": "For @h after administration of each treatment , blood samples were collected for pharmacokinetic analysis and injection sites were assessed .", "sentence_id": 2}
+{"abstract_id": "24728329", "label": "results", "text": "Forty-seven patients completed the study .", "sentence_id": 3}
+{"abstract_id": "24728329", "label": "results", "text": "Systemic exposure of oral MTX plateaued at doses @mg/week .", "sentence_id": 4}
+{"abstract_id": "24728329", "label": "results", "text": "In contrast , SC MTX demonstrated a linear increase in systemic exposure that was greater than oral MTX at each dose .", "sentence_id": 5}
+{"abstract_id": "24728329", "label": "results", "text": "No unexpected AEs were noted for either formulation .", "sentence_id": 6}
+{"abstract_id": "24728329", "label": "conclusions", "text": "Unlike oral MTX , the systemic exposure of SC MTX did not plateau over the doses studied , particularly at doses @mg/week .", "sentence_id": 7}
+{"abstract_id": "24728329", "label": "conclusions", "text": "In this study , higher systemic MTX exposure was not associated with increases in AEs .", "sentence_id": 8}
+{"abstract_id": "24728329", "label": "conclusions", "text": "Patients with an inadequate clinical response to oral MTX may benefit from higher drug exposure by switching to SC MTX .", "sentence_id": 9}
+{"abstract_id": "24401802", "label": "background", "text": "Total knee arthroplasty ( TKA ) is associated with varying degrees of pain .", "sentence_id": 0}
+{"abstract_id": "24401802", "label": "background", "text": "A considerable proportion ( @-@ % ) of patients experience severe pain , despite a comprehensive multimodal analgesic regimen .", "sentence_id": 1}
+{"abstract_id": "24401802", "label": "background", "text": "We hypothesized that adductor canal block ( ACB ) would reduce pain in this patient category compared with placebo .", "sentence_id": 2}
+{"abstract_id": "24401802", "label": "methods", "text": "Fifty patients with severe pain , defined as having a visual analogue scale ( VAS ) pain score of > @ during active flexion of the knee on the first or the second postoperative day after TKA , were included in this randomized , double-blind , placebo-controlled trial .", "sentence_id": 3}
+{"abstract_id": "24401802", "label": "methods", "text": "All the patients had received a comprehensive multimodal analgesic regimen .", "sentence_id": 4}
+{"abstract_id": "24401802", "label": "methods", "text": "Group A received an ACB with ropivacaine @ % , @ ml at time @ and isotonic saline after @ min .", "sentence_id": 5}
+{"abstract_id": "24401802", "label": "methods", "text": "Group B received an ACB with isotonic saline at time @ and ropivacaine @ % , @ ml after @ min .", "sentence_id": 6}
+{"abstract_id": "24401802", "label": "results", "text": "A @-mm difference in VAS pain score , during active flexion of the knee ( primary endpoint ) , was observed in favour of Group A , @ % confidence interval ( CI ) : @-@ , P < @ .", "sentence_id": 7}
+{"abstract_id": "24401802", "label": "results", "text": "At rest , the difference in VAS pain score was @ mm in favour of Group A , @ % CI : @-@ mm , P = @ .", "sentence_id": 8}
+{"abstract_id": "24401802", "label": "results", "text": "Individual patient analysis revealed that @ % of the patients had no effect during active flexion .", "sentence_id": 9}
+{"abstract_id": "24401802", "label": "results", "text": "At rest , however , only @ % had more than mild pain after ACB compared with @ % at inclusion .", "sentence_id": 10}
+{"abstract_id": "24401802", "label": "conclusions", "text": "ACB reduced VAS with @ mm , during active flexion of the knee , in patients with severe pain after TKA , but a large proportion ( @ % ) still had at least moderate , movement-related pain .", "sentence_id": 11}
+{"abstract_id": "24401802", "label": "conclusions", "text": "Clinical trial registration www.clinicaltrials.gov , NCT@ .", "sentence_id": 12}
+{"abstract_id": "24781571", "label": "background", "text": "Radial arterial catheterization in pediatric patients is occasionally difficult despite ultrasound guidance .", "sentence_id": 0}
+{"abstract_id": "24781571", "label": "background", "text": "We therefore assessed the factors affecting catheterization and tested an intervention designed to improve its success .", "sentence_id": 1}
+{"abstract_id": "24781571", "label": "methods", "text": "For initial assessment , we performed multiple logistic regression analyses using @ pediatric patients .", "sentence_id": 2}
+{"abstract_id": "24781571", "label": "methods", "text": "Dependent variables included first-attempt and overall success or failure ; independent variables were systolic blood pressure , weight , ASA physical status , trisomy @ , arterial diameter , and subcutaneous depth of the radial artery ( < @ , @-@ , @ mm ) .", "sentence_id": 3}
+{"abstract_id": "24781571", "label": "methods", "text": "The effect of subcutaneous arterial depth on cannulation success was assessed using Kaplan-Meier curves with log-rank and Dunn tests .", "sentence_id": 4}
+{"abstract_id": "24781571", "label": "methods", "text": "We then assessed catheterization success in @ patients who were randomized to no treatment or subcutaneous saline injection , as necessary , to increase the subcutaneous arterial depth from < @ to @ to @ mm .", "sentence_id": 5}
+{"abstract_id": "24781571", "label": "results", "text": "Subcutaneous arterial depth of @ to @ mm was derived as a significant independent predictor of initial and overall success from the multiple logistic regression analyses .", "sentence_id": 6}
+{"abstract_id": "24781571", "label": "results", "text": "The @ to @ mm group had a significantly shorter catheterization time compared with the other @ groups in the log-rank test ( @-@ vs < @ mm group ; P = @ , @-@ vs @ mm group ; P < @ ) , and higher success rate in the first attempt ( < @ -LSB- @ % -RSB- vs @-@ mm -LSB- @ % -RSB- , P = @ ; @-@ -LSB- @ % -RSB- vs @ mm -LSB- @ % -RSB- , P < @ ) , and the overall attempt ( < @ -LSB- @ % -RSB- vs @-@ mm -LSB- @ % -RSB- , P = @ ; @-@ -LSB- @ % -RSB- vs @ mm -LSB- @ % -RSB- , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24781571", "label": "results", "text": "Injecting subcutaneous saline to bring arterial depth from < @ mm to @ to @ mm significantly shortened catheterization time ( P = @ ) , and improved the success rate in the first-attempt ( saline injection -LSB- @ % -RSB- vs < @ mm -LSB- @ % -RSB- , P < @ ) , and the overall attempt ( saline injection -LSB- @ % -RSB- vs < @ mm -LSB- @ % -RSB- , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24781571", "label": "conclusions", "text": "Ultrasound-guided radial artery catheterization in pediatric patients was fastest and most reliable when the artery was @ to @ mm below the skin surface .", "sentence_id": 9}
+{"abstract_id": "24781571", "label": "conclusions", "text": "For arteries located < @ mm below the skin surface , increasing the depth to @ to @ mm by subcutaneous saline injection reduced catheterization time and improved the success rate .", "sentence_id": 10}
+{"abstract_id": "25239225", "label": "background", "text": "The purpose of this study was to assess the efficacy and safety of trabectedin for advanced breast cancer .", "sentence_id": 0}
+{"abstract_id": "25239225", "label": "methods", "text": "In an open-label , phase II , multicenter study , women with advanced breast cancer previously treated with @ lines of chemotherapy for advanced disease , including both anthracyclines and taxanes , were randomized ( @:@ ) to @-hour infusions of trabectedin @ mg/m ( @ ) once every @ weeks ( @/@ treatment arm ) or @ mg/m ( @ ) every week for @ of @ weeks ( @/@ treatment arm ) .", "sentence_id": 1}
+{"abstract_id": "25239225", "label": "methods", "text": "The primary end point was objective response .", "sentence_id": 2}
+{"abstract_id": "25239225", "label": "methods", "text": "Secondary end points included time to progression ( TTP ) , progression-free survival ( PFS ) , and overall survival ( OS ) .", "sentence_id": 3}
+{"abstract_id": "25239225", "label": "results", "text": "Fifty-two women ( median age , @ years ; median chemotherapy agents , @ ) were enrolled .", "sentence_id": 4}
+{"abstract_id": "25239225", "label": "results", "text": "Relative trabectedin dose intensities were @ % and @ % in the @/@ and @/@ treatment arms , respectively .", "sentence_id": 5}
+{"abstract_id": "25239225", "label": "results", "text": "Objective response rates were @ % ( @ of @ ) and @ % ( @ of @ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "25239225", "label": "results", "text": "Stable disease was observed in @ ( @ % ) and @ ( @ % ) patients in the @/@ and @/@ treatment arms , respectively , with median durations of @ and @ months .", "sentence_id": 7}
+{"abstract_id": "25239225", "label": "results", "text": "Median TTP and PFS were higher in the @/@ treatment arm ( @ months each ) than in the @/@ treatment arm ( @ months each ) .", "sentence_id": 8}
+{"abstract_id": "25239225", "label": "results", "text": "At a median follow-up of @ months in both treatment arms , median OS was not reached in the @/@ treatment arm and was @ months in the @/@ treatment arm .", "sentence_id": 9}
+{"abstract_id": "25239225", "label": "results", "text": "The most frequent drug-related adverse events in the @/@ and @/@ treatment arms , respectively , were alanine aminotransferase ( ALT ) level increases ( @ % vs. @ % ) , nausea ( @ % vs. @ % ) , and asthenia ( @ % vs. @ % ) .", "sentence_id": 10}
+{"abstract_id": "25239225", "label": "results", "text": "Neutropenia and increases in ALT levels were the most frequent grade @/@ events .", "sentence_id": 11}
+{"abstract_id": "25239225", "label": "results", "text": "Both types of events were usually transient and reversible .", "sentence_id": 12}
+{"abstract_id": "25239225", "label": "conclusions", "text": "In the population studied , trabectedin showed a manageable safety profile for both regimens analyzed .", "sentence_id": 13}
+{"abstract_id": "25239225", "label": "conclusions", "text": "There were higher objective response rates and a longer PFS in the @/@ treatment arm compared with the @/@ treatment arm .", "sentence_id": 14}
+{"abstract_id": "26156921", "label": "background", "text": "Endotracheal intubation is a method necessary for controlling and maintaining airway during general anesthesia .", "sentence_id": 0}
+{"abstract_id": "26156921", "label": "background", "text": "Cough and hoarseness are common complications after endotracheal intubation .", "sentence_id": 1}
+{"abstract_id": "26156921", "label": "background", "text": "Inflammation has an important role in postoperative cough and hoarseness outbreak .", "sentence_id": 2}
+{"abstract_id": "26156921", "label": "background", "text": "Also it has been stated that green tea has anti-inflammatory properties .", "sentence_id": 3}
+{"abstract_id": "26156921", "label": "background", "text": "Therefore , the current study has been conducted to investigate green tea gargling solution effect on cough and hoarseness after coronary artery bypass graft ( CABG ) surgery .", "sentence_id": 4}
+{"abstract_id": "26156921", "label": "methods", "text": "In this single-blind , randomized , & controlled clinical trial , we enrolled @ patients undergoing CABG admitted to the ICU .", "sentence_id": 5}
+{"abstract_id": "26156921", "label": "methods", "text": "The intervention group participants were asked to gargle @ cc of green tea solution .", "sentence_id": 6}
+{"abstract_id": "26156921", "label": "methods", "text": "The control group patients gargled @ cc of distilled water .", "sentence_id": 7}
+{"abstract_id": "26156921", "label": "methods", "text": "An hour after extubation , the intervention group patients were asked to gargle @ cc of green tea and the control group patients were required to gargle @ cc of distilled water every @ hour up to @ hour ( each patient for @ times ) .", "sentence_id": 8}
+{"abstract_id": "26156921", "label": "methods", "text": "Moreover , the cough and hoarseness questionnaire was also filled in @ , @ , and @ hours after endotracheal extubation .", "sentence_id": 9}
+{"abstract_id": "26156921", "label": "results", "text": "The results showed no significant differences among the patients in both groups regarding age , gender , body mass index , smoking history , and anesthesia duration .", "sentence_id": 10}
+{"abstract_id": "26156921", "label": "results", "text": "There was a significant difference between the two groups in terms of cough @ hours after removing the endotracheal tube .", "sentence_id": 11}
+{"abstract_id": "26156921", "label": "results", "text": "At other times , there was no significant difference between the two groups considering cough and hoarseness .", "sentence_id": 12}
+{"abstract_id": "26156921", "label": "conclusions", "text": "The present study results showed that green tea gargling does not decrease hoarseness .", "sentence_id": 13}
+{"abstract_id": "26156921", "label": "conclusions", "text": "Though , cough occurrence was less in the intervention group than the other group .", "sentence_id": 14}
+{"abstract_id": "25157406", "label": "objective", "text": "To investigate the genetic influence of @ type @ diabetes susceptibility variants on disease progression measured as risk of early prescription redemption of glucose lowering drugs in screen-detected patients with type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "25157406", "label": "methods", "text": "We studied type @ diabetes progression in @,@ patients with screen-detected type @ diabetes from the ADDITION-Denmark study using information of redeemed prescriptions from the Register of Medicinal Products Statistics from @-@ in Denmark .", "sentence_id": 1}
+{"abstract_id": "25157406", "label": "methods", "text": "Patients were cluster randomized by general practitioners , who were randomized to treat type @ diabetes according to either a conventional or a multifactorial intensive treatment algorithm .", "sentence_id": 2}
+{"abstract_id": "25157406", "label": "methods", "text": "We investigated the genetic influence on diabetes progression by constructing a genetic risk score ( GRS ) of all @ validated type @ diabetes susceptibility variants , a GRS of @ variants linked to - cell function and a GRS of @ variants linked to insulin sensitivity and assessed the association between number of risk alleles and time from diagnosis until first redeemed prescription of either any glucose lowering drug or an insulin drug .", "sentence_id": 3}
+{"abstract_id": "25157406", "label": "results", "text": "The GRS linked to insulin sensitivity only nominally increased the risk of an early prescription redemption with an insulin drug by @ % ( HR -LSB- @ % C.I. -RSB- = @ -LSB- @-@ @ -RSB- , p = @ -RSB- in patients randomized to the intensive treatment group .", "sentence_id": 4}
+{"abstract_id": "25157406", "label": "results", "text": "Furthermore , the strongest univariate predictors of diabetes progression for the intensive treatment group ( measured as time to first insulin ) were younger age ( HR -LSB- @ % C.I. -RSB- = @ -LSB- @-@ @ -RSB- ) , increased BMI ( @ -LSB- @-@ @ -RSB- ) , increased HbA@c ( @ -LSB- @ -@ -RSB- ) , increased TG ( @ -LSB- @-@ @ -RSB- ) and reduced fasting serum HDL ( @ -LSB- @-@ @ -RSB- ) at baseline .", "sentence_id": 5}
+{"abstract_id": "25157406", "label": "results", "text": "Similar results were obtained for the conventional treatment group .", "sentence_id": 6}
+{"abstract_id": "25157406", "label": "conclusions", "text": "Higher levels of HbA@c , fasting circulating levels of triglyceride , lower HDL , larger BMI and younger age are significant determinants of early pharmacological intervention in type @ diabetes .", "sentence_id": 7}
+{"abstract_id": "25157406", "label": "conclusions", "text": "However , known common type @ diabetes-associated gene variants do not appear to significantly affect disease progression .", "sentence_id": 8}
+{"abstract_id": "24555499", "label": "objective", "text": "To determine optimum duration of intraurethral @ % lidocaine jelly for pain relief during outpatient rigid cystoscopy .", "sentence_id": 0}
+{"abstract_id": "24555499", "label": "methods", "text": "This prospective randomized study was conducted between June @ and November @ .", "sentence_id": 1}
+{"abstract_id": "24555499", "label": "methods", "text": "Four hundred consecutive adult males requiring diagnostic rigid cystoscopy were randomized into four groups depending on intraurethral @ % lidocaine jelly dwell time before rigid cystoscopy : jelly was instilled @ , @ , @ , and @ minutes before start of the procedure in group A , B , C , and D patients , respectively .", "sentence_id": 2}
+{"abstract_id": "24555499", "label": "methods", "text": "The patients ' age , patient-reported preoperative anxiety score , patient-reported intraoperative pain score , the surgeon-reported patient 's pain score , and the duration of rigid cystoscopy were recorded and analyzed .", "sentence_id": 3}
+{"abstract_id": "24555499", "label": "results", "text": "The mean age , patient-reported preoperative anxiety score , and duration of rigid cystoscopy were similar between the four groups with no significant difference noted between them .", "sentence_id": 4}
+{"abstract_id": "24555499", "label": "results", "text": "The least and highest mean patient-reported and surgeon-reported intraoperative pain scores were reported in group C ( @ and @ ) patients and group A ( @ and @ ) patients , respectively , while no significant difference was found in these scores between group C and D patients .", "sentence_id": 5}
+{"abstract_id": "24555499", "label": "conclusions", "text": "For male patients undergoing diagnostic rigid cystoscopy , an intraurethral dwell time of @ minutes ( of @mL @ % lidocaine jelly ) provided optimum pain relief .", "sentence_id": 6}
+{"abstract_id": "24755713", "label": "background", "text": "The intervention completion rate is an important metric in behavioral and intervention research ; trials with limited intervention completion rates may have reduced internal validity .", "sentence_id": 0}
+{"abstract_id": "24755713", "label": "background", "text": "We examined intervention completion rates among @ African Americans who had been randomized to an integrated ( INT ) or disease-specific ( DSE ) risk education protocol as part of a comparative effectiveness trial from September @ to August @ .", "sentence_id": 1}
+{"abstract_id": "24755713", "label": "methods", "text": "The interventions were developed by an academic-community partnership using community-based participatory research .", "sentence_id": 2}
+{"abstract_id": "24755713", "label": "methods", "text": "Intervention completion rates were determined based on attendance at all four intervention sessions .", "sentence_id": 3}
+{"abstract_id": "24755713", "label": "methods", "text": "Intervention completers were participants who completed all four sessions and noncompleters were those who did not complete any session or only completed one to three sessions following randomization .", "sentence_id": 4}
+{"abstract_id": "24755713", "label": "results", "text": "Seventy-three percent of participants were intervention completers and @ % were noncompleters .", "sentence_id": 5}
+{"abstract_id": "24755713", "label": "results", "text": "There were no differences in intervention completion based on randomization to INT ( @ % ) or DSE ( @ % ) , sociodemographic factors , or body mass index ( BMI ) in the total sample .", "sentence_id": 6}
+{"abstract_id": "24755713", "label": "results", "text": "Different factors were associated significantly with intervention completion within study groups .", "sentence_id": 7}
+{"abstract_id": "24755713", "label": "results", "text": "Among participants randomized to INT , the odds of intervention completion were greater with higher levels of intrinsic motivation , less exposure to information about diet and cardiovascular disease , and greater BMI .", "sentence_id": 8}
+{"abstract_id": "24755713", "label": "results", "text": "Among participants randomized to DSE , the odds of completing the intervention were associated significantly with older age and greater dietary self-efficacy .", "sentence_id": 9}
+{"abstract_id": "24755713", "label": "conclusions", "text": "Many African Americans are likely to complete risk education interventions .", "sentence_id": 10}
+{"abstract_id": "24755713", "label": "conclusions", "text": "Psychologic characteristics should be considered when determining intervention completion rates following randomization in behavioral and intervention trials .", "sentence_id": 11}
+{"abstract_id": "24581393", "label": "background", "text": "The purpose was to determine whether a brachytherapy boost improves outcomes in patients with advanced nasopharyngeal carcinoma treated with standard chemo-radiotherapy .", "sentence_id": 0}
+{"abstract_id": "24581393", "label": "methods", "text": "Patients with nasopharyngeal carcinoma WHO grades I-III and TNM stages III or non-metastatic stage IV were eligible for this phase III study .", "sentence_id": 1}
+{"abstract_id": "24581393", "label": "methods", "text": "Patients were randomized to either arm ( A ) induction chemotherapy , followed by external beam radiotherapy ( EBRT ) with concomitant cisplatin ( n = @ ) or arm ( B ) , the same schedule plus a brachytherapy boost to the nasopharynx ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24581393", "label": "methods", "text": "The EBRT doses given were @ Gy to the primary tumour and positive lymph nodes and @ Gy to the negative neck .", "sentence_id": 3}
+{"abstract_id": "24581393", "label": "methods", "text": "The additional brachytherapy boost in arm ( B ) was given by either low dose-rate ( LDR - @ Gy ) or high dose-rate ( HDR - @ fractions of @ Gy ) brachytherapy .", "sentence_id": 4}
+{"abstract_id": "24581393", "label": "methods", "text": "The primary endpoint was @-year overall survival ( OS ) and secondary endpoints were : local control , regional control , distant metastasis and grade @-@ adverse events .", "sentence_id": 5}
+{"abstract_id": "24581393", "label": "results", "text": "@ patients were randomized between September @ and December @ .", "sentence_id": 6}
+{"abstract_id": "24581393", "label": "results", "text": "The two arms were comparable with regard to age , gender , stage and grade .", "sentence_id": 7}
+{"abstract_id": "24581393", "label": "results", "text": "@ patients completed treatment .", "sentence_id": 8}
+{"abstract_id": "24581393", "label": "results", "text": "Median follow-up was @ months ( @-@ months ) .", "sentence_id": 9}
+{"abstract_id": "24581393", "label": "results", "text": "The effect of treatment arm , country , age , gender , WHO pathology , stage ( T@-@ , N@-@ versus other ) and chemotherapy on overall survival ( OS ) , disease-free survival ( DFS ) and local recurrence-free survival ( LRFS ) was studied .", "sentence_id": 10}
+{"abstract_id": "24581393", "label": "results", "text": "Stage significantly affected OS ( p = @ ) and DFS ( p = @ ) while age significantly affected OS ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24581393", "label": "results", "text": "None of the other factors studied were significant .", "sentence_id": 12}
+{"abstract_id": "24581393", "label": "results", "text": "The @-year LRFS was @ % and @ % in arms A and B respectively ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24581393", "label": "results", "text": "The @-year regional control rate in the neck was @ % and @ % respectively ( p = @ ) .", "sentence_id": 14}
+{"abstract_id": "24581393", "label": "results", "text": "Distant metastasis developed in @ % of patients in arm A and @ % in arm B ( p = @ ) .", "sentence_id": 15}
+{"abstract_id": "24581393", "label": "results", "text": "Patients with T@/T@ N + had a @ year LRFS of @ % in Arm A ( @ patients ) versus @ % in Arm B ( @ patients ) ( p = @ ) .", "sentence_id": 16}
+{"abstract_id": "24581393", "label": "results", "text": "The grade @-@ toxicity rate was @ % ( @/@ ) and @ % ( @/@ ) respectively ( p = @ ) .", "sentence_id": 17}
+{"abstract_id": "24581393", "label": "conclusions", "text": "The addition of a brachytherapy boost to external beam radiotherapy and chemotherapy did not improve outcome in loco-regionally advanced nasopharyngeal carcinoma .", "sentence_id": 18}
+{"abstract_id": "24629504", "label": "objective", "text": "This randomized controlled trial of outpatients with breast cancer ( stage I or II ) evaluated the effects of a @-week educational intervention on patient levels of fatigue .", "sentence_id": 0}
+{"abstract_id": "24629504", "label": "methods", "text": "Norwegian outpatients were randomized into an intervention group ( n = @ ) and a control group ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24629504", "label": "methods", "text": "Women with fatigue ( > @ on a @-@ numeric rating scale , NRS ) completed the Fatigue Questionnaire ( FQ ) and the Lee Fatigue Scale ( LFS ) at baseline ( after treatment ) ( T@ ) , immediately after intervention ( T@ ) and @ months after intervention ( T@ ) .", "sentence_id": 2}
+{"abstract_id": "24629504", "label": "results", "text": "The mean fatigue score ( NRS ) at study entry was @ ( SD @ ) and @ % ( n = @ ) had a score @ .", "sentence_id": 3}
+{"abstract_id": "24629504", "label": "results", "text": "There were no statistically significant differences between the fatigue measures of women in the intervention and control group at T@ or T@ in the overall sample after the intervention .", "sentence_id": 4}
+{"abstract_id": "24629504", "label": "results", "text": "Using an NRS cut-off of @ , there was a borderline difference for women who scored < @ for chronic fatigue on FQ ( p = @ ) and a significant difference for energy on LFS ( p = @ ) where the women in the intervention group had less fatigue .", "sentence_id": 5}
+{"abstract_id": "24629504", "label": "results", "text": "Using an NRS cut-off score of @ , there was a borderline difference for women who scored < @ for fatigue on FQ ( p = @ ) and a significant difference for energy on LFS ( p = @ ) where women in the intervention group had more energy than those in the control group .", "sentence_id": 6}
+{"abstract_id": "24629504", "label": "conclusions", "text": "Further research is needed to identify psycho-educational interventions to reduce levels of fatigue and to tailor an intervention based on the level of fatigue .", "sentence_id": 7}
+{"abstract_id": "24629504", "label": "conclusions", "text": "Fatigue measurements should be chosen more carefully .", "sentence_id": 8}
+{"abstract_id": "24286967", "label": "background", "text": "Heavy alcohol consumption in HIV patients is an increasing health concern .", "sentence_id": 0}
+{"abstract_id": "24286967", "label": "background", "text": "Applying the drinking motivational model to HIV primary care patients , drinking motives ( drinking to cope with negative affect , for social facilitation , and in response to social pressure ) were associated with alcohol consumption at a baseline interview .", "sentence_id": 1}
+{"abstract_id": "24286967", "label": "background", "text": "However , whether these motives predict continued heavy drinking or alcohol dependence in this population is unknown .", "sentence_id": 2}
+{"abstract_id": "24286967", "label": "methods", "text": "Participants were @ heavy-drinking urban HIV primary care patients ( @ % male ; @ % African American or Hispanic ) participating in a randomized trial of brief drinking-reduction interventions .", "sentence_id": 3}
+{"abstract_id": "24286967", "label": "methods", "text": "Drinking motive scales , as well as measures of alcohol consumption and alcohol dependence , were administered at baseline .", "sentence_id": 4}
+{"abstract_id": "24286967", "label": "methods", "text": "Consumption and dependence measures were re-administered at the end of treatment two months later .", "sentence_id": 5}
+{"abstract_id": "24286967", "label": "methods", "text": "Regression analyses tested whether baseline drinking motive scale scores predicted continued heavy drinking and alcohol dependence status at the end of treatment , and whether motives interacted with treatment condition .", "sentence_id": 6}
+{"abstract_id": "24286967", "label": "results", "text": "Baseline drinking to cope with negative affect predicted continued heavy drinking ( p < @ ) and alcohol dependence , the latter in both in the full sample ( adjusted odds ratio -LSB- AOR -RSB- = @ ) and among those with baseline dependence ( AOR = @ ) .", "sentence_id": 7}
+{"abstract_id": "24286967", "label": "results", "text": "Motives did not interact with treatment condition in predicting alcohol outcomes .", "sentence_id": 8}
+{"abstract_id": "24286967", "label": "conclusions", "text": "Drinking to cope with negative affect may identify HIV patients needing targeted intervention to reduce drinking , and may inform development of more effective interventions addressing ways other than heavy drinking to cope with negative affect .", "sentence_id": 9}
+{"abstract_id": "24678937", "label": "background", "text": "We compared transcatheter aortic-valve replacement ( TAVR ) , using a self-expanding transcatheter aortic-valve bioprosthesis , with surgical aortic-valve replacement in patients with severe aortic stenosis and an increased risk of death during surgery .", "sentence_id": 0}
+{"abstract_id": "24678937", "label": "methods", "text": "We recruited patients with severe aortic stenosis who were at increased surgical risk as determined by the heart team at each study center .", "sentence_id": 1}
+{"abstract_id": "24678937", "label": "methods", "text": "Risk assessment included the Society of Thoracic Surgeons Predictor Risk of Mortality estimate and consideration of other key risk factors .", "sentence_id": 2}
+{"abstract_id": "24678937", "label": "methods", "text": "Eligible patients were randomly assigned in a @:@ ratio to TAVR with the self-expanding transcatheter valve ( TAVR group ) or to surgical aortic-valve replacement ( surgical group ) .", "sentence_id": 3}
+{"abstract_id": "24678937", "label": "methods", "text": "The primary end point was the rate of death from any cause at @ year , evaluated with the use of both noninferiority and superiority testing .", "sentence_id": 4}
+{"abstract_id": "24678937", "label": "results", "text": "A total of @ patients underwent randomization at @ centers in the United States .", "sentence_id": 5}
+{"abstract_id": "24678937", "label": "results", "text": "In the as-treated analysis , the rate of death from any cause at @ year was significantly lower in the TAVR group than in the surgical group ( @ % vs. @ % ) , with an absolute reduction in risk of @ percentage points ( upper boundary of the @ % confidence interval , -@ ; P < @ for noninferiority ; P = @ for superiority ) .", "sentence_id": 6}
+{"abstract_id": "24678937", "label": "results", "text": "The results were similar in the intention-to-treat analysis .", "sentence_id": 7}
+{"abstract_id": "24678937", "label": "results", "text": "In a hierarchical testing procedure , TAVR was noninferior with respect to echocardiographic indexes of valve stenosis , functional status , and quality of life .", "sentence_id": 8}
+{"abstract_id": "24678937", "label": "results", "text": "Exploratory analyses suggested a reduction in the rate of major adverse cardiovascular and cerebrovascular events and no increase in the risk of stroke .", "sentence_id": 9}
+{"abstract_id": "24678937", "label": "conclusions", "text": "In patients with severe aortic stenosis who are at increased surgical risk , TAVR with a self-expanding transcatheter aortic-valve bioprosthesis was associated with a significantly higher rate of survival at @ year than surgical aortic-valve replacement .", "sentence_id": 10}
+{"abstract_id": "24678937", "label": "conclusions", "text": "( Funded by Medtronic ; U.S. CoreValve High Risk Study ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "25321659", "label": "background", "text": "Omega-@ fatty acid supplements have been reported to inhibit exercise-induced bronchoconstriction ( EIB ) .", "sentence_id": 0}
+{"abstract_id": "25321659", "label": "background", "text": "It has not been determined whether omega-@ supplements inhibit airway sensitivity to inhaled mannitol , a test for bronchial hyperresponsiveness ( BHR ) and model for EIB in people with mild to moderate asthma .", "sentence_id": 1}
+{"abstract_id": "25321659", "label": "methods", "text": "In a double-blind , crossover trial , subjects with asthma who had BHR to inhaled mannitol ( n = @ ; @ men ; mean age , @ years ; one-half taking regular inhaled corticosteroids ) were randomized to omega-@ supplements ( @ g/d eicosapentaenoic acid and @ g/d docosahexaenoic acid ) or matching placebo for @ weeks separated by a @-week washout .", "sentence_id": 2}
+{"abstract_id": "25321659", "label": "methods", "text": "The primary outcome was the provoking dose of mannitol ( mg ) to cause a @ % fall in FEV@ ( PD@ ) .", "sentence_id": 3}
+{"abstract_id": "25321659", "label": "methods", "text": "Secondary outcomes were sputum eosinophil count , spirometry , Asthma Control Questionnaire ( ACQ ) score , serum triacylglyceride level , and lipid mediator profile in urine and serum .", "sentence_id": 4}
+{"abstract_id": "25321659", "label": "results", "text": "PD@ ( geometric mean , @ % CI ) to mannitol following supplementation with omega-@s ( @ mg , @-@ mg ) was not different from placebo ( @ mg , @-@ mg , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25321659", "label": "results", "text": "There were no changes in sputum eosinophils ( mean SD ) in a subgroup of @ subjects ( omega-@ , @ % @ % ; placebo , @ % @ % ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25321659", "label": "results", "text": "At the end of each treatment period , there were no differences in FEV@ % predicted ( omega-@ , @ % @ % ; placebo , @ % @ % ; P = @ ) or ACQ score ( omega-@ , @ % @ % ; placebo , @ % @ % ; P = @ ) ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "25321659", "label": "results", "text": "Omega-@s caused significant lowering of blood triglyceride levels and expected shifts in serum fatty acids and eicosanoid metabolites , confirming adherence to the supplements ; however , no changes were observed in urinary mast cell mediators .", "sentence_id": 8}
+{"abstract_id": "25321659", "label": "conclusions", "text": "Three weeks of omega-@ supplements does not improve BHR to mannitol , decrease sputum eosinophil counts , or inhibit urinary excretion of mast cell mediators in people with mild to moderate asthma , indicating that dietary omega-@ supplementation is not useful in the short-term treatment of asthma .", "sentence_id": 9}
+{"abstract_id": "24311403", "label": "background", "text": "Catecholamines and inflammatory mediators , with elevated levels after brain death , are associated with reduced function and survival of transplanted organs .", "sentence_id": 0}
+{"abstract_id": "24311403", "label": "background", "text": "Enteral nutrition reduces tissue damage and may benefit organs .", "sentence_id": 1}
+{"abstract_id": "24311403", "label": "objective", "text": "To evaluate the effects of immunomodulating enteral nutrition in organ donors .", "sentence_id": 2}
+{"abstract_id": "24311403", "label": "methods", "text": "Prospective , randomized , open-label study .", "sentence_id": 3}
+{"abstract_id": "24311403", "label": "methods", "text": "Intensive care unit .", "sentence_id": 4}
+{"abstract_id": "24311403", "label": "methods", "text": "Thirty-six brain-dead organ donors .", "sentence_id": 5}
+{"abstract_id": "24311403", "label": "methods", "text": "Donors were randomized to receive enteral nutrition containing omega-@ polyunsaturated fatty acid , antioxidants , and glutamine or standard care ( fasting ) .", "sentence_id": 6}
+{"abstract_id": "24311403", "label": "methods", "text": "Donors received hormonal replacement therapy of corticosteroid , levothyroxine , dextrose , and insulin .", "sentence_id": 7}
+{"abstract_id": "24311403", "label": "methods", "text": "Gastrointestinal assimilation ( measured by @ carbon-labeled uracil breath analysis ) , quantity of organs recovered , resting energy expenditure , urine level of urea nitrogen , and serum levels of albumin , prealbumin , interleukin @ , tumor necrosis factor - , and C-reactive protein were evaluated .", "sentence_id": 8}
+{"abstract_id": "24311403", "label": "results", "text": "Thirteen patients ( @ % ) assimilated @C-labeled uracil .", "sentence_id": 9}
+{"abstract_id": "24311403", "label": "results", "text": "Resting energy expenditure was significantly higher than predicted between @ and @ hours after baseline in @ donors ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24311403", "label": "results", "text": "Other measures were not conclusively different between fed and fasting groups .", "sentence_id": 11}
+{"abstract_id": "24311403", "label": "results", "text": "No adverse events occurred that were related to the enteral feeding .", "sentence_id": 12}
+{"abstract_id": "24311403", "label": "conclusions", "text": "About @ % of donors metabolized @C-labeled uracil , although no difference in oxidation rate was found between fasting and fed donors .", "sentence_id": 13}
+{"abstract_id": "24311403", "label": "conclusions", "text": "Corticosteroid administration lowers plasma levels of interleukin @ and most likely contributes to greater than predicted resting energy expenditure .", "sentence_id": 14}
+{"abstract_id": "24311403", "label": "conclusions", "text": "Thus energy needs may not be met during fasting if hormones are given .", "sentence_id": 15}
+{"abstract_id": "24311403", "label": "conclusions", "text": "Consequences of this possible energy deficit warrant further study .", "sentence_id": 16}
+{"abstract_id": "24666633", "label": "background", "text": "Over @ % of American women @-@ years old are at risk for type @ diabetes , cardiovascular disease , and other health conditions because they are overweight or obese .", "sentence_id": 0}
+{"abstract_id": "24666633", "label": "background", "text": "The prevalence of overweight and obesity is disproportionately high among low-income women .", "sentence_id": 1}
+{"abstract_id": "24666633", "label": "background", "text": "This paper describes the study design and rationale of a community based intervention ( Mothers In Motion , MIM ) aimed to prevent weight gain among low-income overweight and obese mothers @-@ years old by promoting stress management , healthy eating , and physical activity .", "sentence_id": 2}
+{"abstract_id": "24666633", "label": "methods", "text": "Peer recruiters approach participants from @ Special Supplemental Nutrition Program for Women , Infants , and Children ( WIC ) in Michigan .", "sentence_id": 3}
+{"abstract_id": "24666633", "label": "methods", "text": "The MIM delivers theory-based , culturally-sensitive intervention messages via a combination of DVDs and peer support group teleconferences ( PSGTs ) .", "sentence_id": 4}
+{"abstract_id": "24666633", "label": "methods", "text": "The DVD features African American and white overweight and obese WIC mothers who participated in a healthy lifestyle intervention patterned after MIM .", "sentence_id": 5}
+{"abstract_id": "24666633", "label": "methods", "text": "The PSGTs are led by paraprofessionals from Michigan State University Extension and WIC providers in Michigan who are trained in motivational interviewing and group facilitation skills .", "sentence_id": 6}
+{"abstract_id": "24666633", "label": "methods", "text": "Participants are randomly assigned to an intervention ( n = @ ) or comparison group ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "24666633", "label": "methods", "text": "The intervention group receives a @-week intervention on a weekly or bi-weekly basis .", "sentence_id": 8}
+{"abstract_id": "24666633", "label": "methods", "text": "Participants are asked to watch @ MIM DVD chapters at home and join @ PSGT sessions by phone .", "sentence_id": 9}
+{"abstract_id": "24666633", "label": "methods", "text": "The comparison group receives printed educational materials .", "sentence_id": 10}
+{"abstract_id": "24666633", "label": "methods", "text": "The primary outcome is body weight .", "sentence_id": 11}
+{"abstract_id": "24666633", "label": "methods", "text": "Secondary outcomes include dietary fat , fruit , and vegetable intake ; physical activity ; stress , and affect .", "sentence_id": 12}
+{"abstract_id": "24666633", "label": "methods", "text": "Mediators are self-efficacy , emotional coping response , social support , and autonomous motivation .", "sentence_id": 13}
+{"abstract_id": "24666633", "label": "methods", "text": "Telephone interviews and in-person data collection at WIC offices occur at @ time points : baseline , immediately , and @ months after the @-week intervention .", "sentence_id": 14}
+{"abstract_id": "24666633", "label": "conclusions", "text": "If MIM shows effectiveness , it could have a favorable impact on public health and community programs .", "sentence_id": 15}
+{"abstract_id": "24666633", "label": "conclusions", "text": "The DVDs and PSGTs will be disseminated in WIC , Extension , clinical practice that promote healthy lifestyles for similar target audiences to make a broad contribution to the prevention of weight gain in low-income mothers .", "sentence_id": 16}
+{"abstract_id": "24666633", "label": "conclusions", "text": "Also , our methodology can be adapted by researchers and community stakeholders to help other low-income populations prevent weight gain .", "sentence_id": 17}
+{"abstract_id": "25602456", "label": "background", "text": "Deep sedation of surgical patients may be associated with hypoventilation , airway collapse , and hypercarbia , although the extent of hypercarbia is rarely quantified .", "sentence_id": 0}
+{"abstract_id": "25602456", "label": "background", "text": "In this prospective , randomized , controlled clinical pilot study , we assessed the efficacy of nasal continuous positive airway pressure ( nCPAP ) for reducing arterial partial pressure of carbon dioxide ( PaCO@ ) among deeply sedated , spontaneously ventilated patients undergoing total knee arthroplasty ( TKA ) under subarachnoid block ( SAB ) , versus standard airway management in a control group .", "sentence_id": 1}
+{"abstract_id": "25602456", "label": "methods", "text": "Forty ASA status I-III patients underwent deep sedation with propofol to level @ on the Modified Observers Assessment of Alertness/Sedation Scale during TKA performed under SAB .", "sentence_id": 2}
+{"abstract_id": "25602456", "label": "methods", "text": "Nasal or oral airways were placed at the discretion of the anesthesia team , but they were not used in conjunction with nCPAP .", "sentence_id": 3}
+{"abstract_id": "25602456", "label": "methods", "text": "Baseline arterial blood gas analysis ( ABG-@ ) was performed after Modified Observers Assessment of Alertness/Sedation Scale level @ was reached .", "sentence_id": 4}
+{"abstract_id": "25602456", "label": "methods", "text": "Patients were then randomized to receive nCPAP ( nCPAP group , N = @ ) or standard oxygen mask management ( control group , N = @ ) .", "sentence_id": 5}
+{"abstract_id": "25602456", "label": "methods", "text": "A second ABG ( ABG-@ ) was performed @ minutes later to assess the effect of nCPAP on PaCO@ .", "sentence_id": 6}
+{"abstract_id": "25602456", "label": "methods", "text": "The primary efficacy end point was change in PaCO@ from baseline to the @-minute time point .", "sentence_id": 7}
+{"abstract_id": "25602456", "label": "results", "text": "Baseline ( ABG-@ ) PaCO@ values were similar between nCPAP and control groups with median values of @ and @ mm Hg , respectively .", "sentence_id": 8}
+{"abstract_id": "25602456", "label": "results", "text": "There was a significant decline in PaCO@ in the nCPAP group ( median of -@ mm Hg -LSB- @th-@th quantile , -@ to @ -RSB- ) as compared with the control group ( median of @ mm Hg -LSB- -@ to @ -RSB- ; P = @ ; @ % confidence interval -LSB- CI -RSB- for location shift = -@ to -@ ) .", "sentence_id": 9}
+{"abstract_id": "25602456", "label": "results", "text": "Within the control group , PaCO@ was similar from ABG-@ to ABG-@ ( median -LSB- @th-@th quantile -RSB- = @ mm Hg -LSB- @-@ @ -RSB- vs @ mm Hg -LSB- @-@ @ -RSB- ; P = @ ; @ % CI for the median = -@ to @ ) .", "sentence_id": 10}
+{"abstract_id": "25602456", "label": "results", "text": "Forty percent of all patients received an airway before ABG-@ .", "sentence_id": 11}
+{"abstract_id": "25602456", "label": "results", "text": "The baseline PaCO@ value of patients receiving an airway was not different from that of patients without an airway ( median -LSB- @th-@th quantile -RSB- = @ mm Hg -LSB- @-@ @ -RSB- vs @ mm Hg -LSB- @-@ @ -RSB- , respectively ; P = @ ; @ % CI for location shift = -@ to @ ) .", "sentence_id": 12}
+{"abstract_id": "25602456", "label": "conclusions", "text": "Deep sedation of TKA patients during SAB resulted in moderate hypercarbia ( mean and median PaCO@ = @ ) .", "sentence_id": 13}
+{"abstract_id": "25602456", "label": "conclusions", "text": "There was a trend showing that nCPAP treatment reduced PaCO@ versus treatment for control group patients receiving standard airway management ; however , estimated treatment difference varied widely , from @ to @ mm Hg .", "sentence_id": 14}
+{"abstract_id": "25602456", "label": "conclusions", "text": "Among control group patients , the initial PaCO@ during deep sedation was similar to the PaCO@ when measured after a @-minute period of continued deep sedation .", "sentence_id": 15}
+{"abstract_id": "25602456", "label": "conclusions", "text": "Finally , baseline PaCO@ among deeply sedated patients who received an airway was not different from that of patients who did not receive an airway .", "sentence_id": 16}
+{"abstract_id": "25352893", "label": "background", "text": "Funnel technique is a method used for the insertion of screw into thoracic pedicle .", "sentence_id": 0}
+{"abstract_id": "25352893", "label": "objective", "text": "To evaluate the biomechanical characteristics of thoracic pedicle screw placement using the Funnel technique , trying to provide biomechanical basis for clinical application of this technology .", "sentence_id": 1}
+{"abstract_id": "25352893", "label": "methods", "text": "@ functional spinal units ( T@ to T@ ) were selected from thoracic spine specimens of @ fresh adult cadavers , and randomly divided into two groups , including Funnel technique group ( n = @ ) and Magerl technique group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25352893", "label": "methods", "text": "The displacement-stiffness and pull-out strength in all kinds of position were tested and compared .", "sentence_id": 3}
+{"abstract_id": "25352893", "label": "results", "text": "Two fixed groups were significantly higher than that of the intact state ( P < @ ) in the spinal central axial direction , compression , anterior flexion , posterior bending , lateral bending , axial torsion , but there were no significant differences between two fixed groups ( P > @ ) .", "sentence_id": 4}
+{"abstract_id": "25352893", "label": "results", "text": "The mean pull-out strength in Funnel technique group ( @ @ ) was lower than that in Magerl technique group ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25352893", "label": "conclusions", "text": "The Funnel technique for the insertion point of posterior bone is a safe and accurate technique for pedicle screw placement .", "sentence_id": 6}
+{"abstract_id": "25352893", "label": "conclusions", "text": "It exhibited no effects on the stiffness of spinal column , but decreased the pull-out strength of pedicle screw .", "sentence_id": 7}
+{"abstract_id": "25352893", "label": "conclusions", "text": "Therefore , the funnel technique in the thoracic spine affords an alternative for the standard screw placement .", "sentence_id": 8}
+{"abstract_id": "25054390", "label": "background", "text": "Thoracic epidural analgesia ( TEA ) has a well-known effect on neurohormonal response .", "sentence_id": 0}
+{"abstract_id": "25054390", "label": "background", "text": "Attenuation of stress response by post-operative epidural analgesia has shown beneficial effects such as lower pain scores and less immunological alterations .", "sentence_id": 1}
+{"abstract_id": "25054390", "label": "objective", "text": "Investigation of the combined effects of TEA and protective lung ventilation on pro-inflammatory cytokines and patients ' outcome after Ivor Lewis esophagectomy .", "sentence_id": 2}
+{"abstract_id": "25054390", "label": "methods", "text": "A randomized controlled study .", "sentence_id": 3}
+{"abstract_id": "25054390", "label": "methods", "text": "Academic medical center .", "sentence_id": 4}
+{"abstract_id": "25054390", "label": "methods", "text": "Thirty patients of the American Society of Anesthesiologists ( ASA ) I and II were randomly allocated into @ groups : G@ ( n = @ ) patients received general anesthesia and were mechanically ventilated with @ mL/kg during @ lung ventilations , reduced to @ mL/kg and @cm H@O positive end expiratory pressure ( PEEP ) during one lung ventilation ( OLV ) or GII ) ( n = @ ) patients received TEA and the same general anesthesia and mechanical ventilation used in G@ .", "sentence_id": 5}
+{"abstract_id": "25054390", "label": "methods", "text": "Assessment parameters included hemodynamics , pain severity , total analgesic consumption , and measurement of interleukins ( IL ) ( IL-@ and IL-@ ) at baseline time after anesthetic induction ( TBaseline , ) ; at the end of the abdominal stage of the operation ( TAbdo , ) ; @ minutes after initiation and at the end of OLV ( TOLV @ ) and ( TOLV End ) respectively ; one and @ hours after the end of the surgical procedure ( TPostop@ and TPostop@ ) , respectively , and patient 's outcome also recorded .", "sentence_id": 6}
+{"abstract_id": "25054390", "label": "results", "text": "There was a significant reduction in mean arterial blood pressure ( MAP ) and pulse rate in GII during the intraoperative period , at Tabdo , TOLV@ , and TOLV End ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25054390", "label": "results", "text": "The mean of systolic blood pressure ( SBP ) values were significantly lower in GII over all @ post-operative days ( P = @ ) , and the mean diastolic blood pressure ( DBP ) showed a significant reduction in GII for @ hours post-operatively ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25054390", "label": "results", "text": "The mean of heart rate values showed a significant reduction in GII over all @ post-operative days in comparison to GI ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25054390", "label": "results", "text": "The mean resting and dynamic VAS scores were significantly reduced in GII at all time periods studied in comparison to G@ ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25054390", "label": "results", "text": "The daily PCA morphine consumption was markedly decreased in GII compared to GI in the first @ days post-operatively ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25054390", "label": "results", "text": "There were significant reductions in blood level of IL-@ and IL-@ in GII compared to G@ over the entire study period ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25054390", "label": "results", "text": "There were no significant differences in post-operative adverse effects between the @ groups ( P > @ ) .", "sentence_id": 13}
+{"abstract_id": "25054390", "label": "results", "text": "The duration of stay in PACU was significantly decreased in GII ( @ @ days ) compared to GI ( @ @ days ) ( P = @ ) .", "sentence_id": 14}
+{"abstract_id": "25054390", "label": "conclusions", "text": "This study is limited by its sample size .", "sentence_id": 15}
+{"abstract_id": "25054390", "label": "conclusions", "text": "Our study concluded that TEA reduced the systemic pro-inflammatory response and provided optimal post-operative pain relief .", "sentence_id": 16}
+{"abstract_id": "25054390", "label": "conclusions", "text": "Although there were no significant differences in adverse events , there was a trend towards improved outcome .", "sentence_id": 17}
+{"abstract_id": "25054390", "label": "conclusions", "text": "Further clinical studies with larger numbers of patients are required .", "sentence_id": 18}
+{"abstract_id": "24879143", "label": "objective", "text": "Laparoscopic cholecystectomy ( LC ) , a gold standard procedure can be done without energized dissection ( ED ) .", "sentence_id": 0}
+{"abstract_id": "24879143", "label": "objective", "text": "We did a randomized study for the outcomes of LC done with ED or without ED , i.e. , with cold dissection ( CD ) .", "sentence_id": 1}
+{"abstract_id": "24879143", "label": "methods", "text": "At a tertiary level institution , open-ended prospective-randomized control study was conducted between September @ and June @ .", "sentence_id": 2}
+{"abstract_id": "24879143", "label": "methods", "text": "Consecutive , unselected , consenting candidates for LC were enrolled following standard ethics , informed consent , anesthesia , and clinical pathway protocol .", "sentence_id": 3}
+{"abstract_id": "24879143", "label": "methods", "text": "They were allocated to control group ( LC with ED ) or study group ( LC with CD , as per our published technique with the option for rescue ED ) .", "sentence_id": 4}
+{"abstract_id": "24879143", "label": "methods", "text": "The study points were based upon Clavien-Dindo grading of postoperative complications .", "sentence_id": 5}
+{"abstract_id": "24879143", "label": "methods", "text": "They were either , peri-operative events potentially affecting , hospital stay ( Grade I ) or Grade II-V , e.g. , peri-operative hemodynamic instability , needing intervention/blood transfusion , injury to biliary ducts/hollow viscous , postoperative biliary leak , postoperative re-intervention , re-hospitalization , mortality , and any adverse event during a @-day follow-up period .", "sentence_id": 6}
+{"abstract_id": "24879143", "label": "methods", "text": "The data were prospectively collected in an integrated `` hospital information system '' that could be retrieved only by independent external coordinators .", "sentence_id": 7}
+{"abstract_id": "24879143", "label": "results", "text": "Demographics , co-morbidities , and gallbladder inflammation profile of the control group ( n = @ ) and study group ( n = @ ) were comparable .", "sentence_id": 8}
+{"abstract_id": "24879143", "label": "results", "text": "There was no rescue ED usage in the study group .", "sentence_id": 9}
+{"abstract_id": "24879143", "label": "results", "text": "Hospital stay ( Grade I adverse outcome dependent ) was longer , i.e. , @ @ in the control versus @ @ days in the study group ( p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24879143", "label": "results", "text": "Grade II-IV complications were significantly more ( p < @ ) in control group .", "sentence_id": 11}
+{"abstract_id": "24879143", "label": "results", "text": "There was one common bile duct ( CBD ) injury in each group .", "sentence_id": 12}
+{"abstract_id": "24879143", "label": "results", "text": "The index bilio-enteric anastomosis for CBD injury in control group failed and needed a revision with multiple interventions .", "sentence_id": 13}
+{"abstract_id": "24879143", "label": "results", "text": "There was one grade V adverse outcome , i.e. , mortality in the control group .", "sentence_id": 14}
+{"abstract_id": "24879143", "label": "conclusions", "text": "Avoiding the use of ED in LC is associated with better outcomes .", "sentence_id": 15}
+{"abstract_id": "24880956", "label": "background", "text": "Surgical site infections ( SSIs ) are responsible for significant morbidity , mortality , and excess use of health care resources .", "sentence_id": 0}
+{"abstract_id": "24880956", "label": "background", "text": "The preadmission antiseptic shower is accepted as an effective strategy for reducing the risk for SSIs .", "sentence_id": 1}
+{"abstract_id": "24880956", "label": "background", "text": "The study analyzes the benefit of an innovative electronic patient alert system ( EAS ) for enhancing compliance with a preadmission showering protocol with @ % chlorhexidine gluconate ( CHG ) .", "sentence_id": 2}
+{"abstract_id": "24880956", "label": "methods", "text": "After providing informed consent , @ volunteers were randomized to @ CHG showering groups .", "sentence_id": 3}
+{"abstract_id": "24880956", "label": "methods", "text": "Groups A@ and A@ showered twice .", "sentence_id": 4}
+{"abstract_id": "24880956", "label": "methods", "text": "Group A@ was prompted to shower via EAS .", "sentence_id": 5}
+{"abstract_id": "24880956", "label": "methods", "text": "Groups B@ and B@ showered @ times .", "sentence_id": 6}
+{"abstract_id": "24880956", "label": "methods", "text": "Group B@ was prompted via EAS .", "sentence_id": 7}
+{"abstract_id": "24880956", "label": "methods", "text": "Subjects in groups A@ and B@ were not prompted ( non-EAS groups ) .", "sentence_id": 8}
+{"abstract_id": "24880956", "label": "methods", "text": "Skin-surface concentrations of CHG ( g/mL ) were analyzed using colorimetric assay at @ separate anatomic sites .", "sentence_id": 9}
+{"abstract_id": "24880956", "label": "methods", "text": "Study personnel were blinded to the randomization code ; after final volunteer processing , the code was broken and individual groups were analyzed .", "sentence_id": 10}
+{"abstract_id": "24880956", "label": "results", "text": "Mean composite CHG skin-surface concentrations were significantly higher ( p < @ ) in EAS groups A@ ( @ @ g/mL ) and B@ ( @ @ g/mL ) compared with non-EAS groups A@ ( @ @ g/mL ) and B@ ( @ @ g/mL ) .", "sentence_id": 11}
+{"abstract_id": "24880956", "label": "results", "text": "Overall , @ % and @ % reductions in CHG skin-surface concentrations were observed in non-EAS groups A@ and B@ compared with EAS study groups .", "sentence_id": 12}
+{"abstract_id": "24880956", "label": "results", "text": "Analysis of returned ( unused ) CHG ( mL ) suggests that a wide variation in volume of biocide was used per shower in all groups .", "sentence_id": 13}
+{"abstract_id": "24880956", "label": "conclusions", "text": "The findings suggest that EAS was effective in enhancing patient compliance with a preadmission showering protocol , resulting in a significant ( p < @ ) increase in skin-surface concentrations of CHG compared with non-EAS controls .", "sentence_id": 14}
+{"abstract_id": "24880956", "label": "conclusions", "text": "However , variation in amount of unused @ % CHG suggests that rigorous standardization is required to maximize the benefits of this patient-centric interventional strategy .", "sentence_id": 15}
+{"abstract_id": "24864326", "label": "objective", "text": "To compare the efficacy and safety outcomes of bimanual microincision cataract surgery ( MICS ) versus @-mm coaxial phacoemulsification assisted by Femtosecond LenSx ( Alcon-LenSx Inc. , Aliso Viejo , CA ) .", "sentence_id": 0}
+{"abstract_id": "24864326", "label": "methods", "text": "This prospective , randomized , observational , comparative case series comprised @ cataractous eyes of @ patients receiving femtosecond laser refractive lens surgery followed by a bimanual MICS technique with two @-mm incisions ( @ patients ) ( FemtoMICS group ) and a coaxial phacoemulsification technique with a @-mm paracentesis and a @-mm principal incision ( @ patients ) ( FemtoCoaxial group ) .", "sentence_id": 1}
+{"abstract_id": "24864326", "label": "methods", "text": "The main outcomes measures were : ultrasound power , effective phacoemulsification time , postoperative spherical equivalent , higher-order aberrations ( corneal and internal ) , corneal thickness , endothelial cell count , macular thickness , and complications during and after surgery .", "sentence_id": 2}
+{"abstract_id": "24864326", "label": "methods", "text": "Both groups were absolutely comparable for all variables preoperatively .", "sentence_id": 3}
+{"abstract_id": "24864326", "label": "results", "text": "Mean ultrasound power was @ % @ % for MICS and @ % @ % for @-mm incisions ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24864326", "label": "results", "text": "Effective phacoemulsification time values for MICS and @-mm incisions were @ @ and @ @ sec , respectively ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24864326", "label": "results", "text": "Mean postoperative spherical equivalent was @ for FemtoMICS and @ for FemtoCoaxial ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24864326", "label": "results", "text": "The efficacy index at @ month postoperatively was @ % for FemtoMICS and @ % for FemtoCoaxial .", "sentence_id": 7}
+{"abstract_id": "24864326", "label": "results", "text": "No significant differences were found in corneal thickness , endothelial cell count , and macular thickness .", "sentence_id": 8}
+{"abstract_id": "24864326", "label": "results", "text": "Complications included posterior capsule rupture ( @ % ) and anterior capsule rupture with no posterior capsule tear ( @ % ) for FemtoMICS and bridges due to incomplete capsulorhexis ( @ % ) for FemtoCoaxial .", "sentence_id": 9}
+{"abstract_id": "24864326", "label": "conclusions", "text": "MICS and coaxial phacoemulsification techniques assisted by the Femtosecond LenSx achieved excellent safety and efficient outcomes .", "sentence_id": 10}
+{"abstract_id": "24864326", "label": "conclusions", "text": "The FemtoMICS technique was surgically and statistically more efficient than the FemtoCoaxial technique .", "sentence_id": 11}
+{"abstract_id": "25218783", "label": "objective", "text": "MicroRNA-@ ( miR-@ ) is an important host factor for hepatitis C virus ( HCV ) and promotes HCV RNA accumulation .", "sentence_id": 0}
+{"abstract_id": "25218783", "label": "objective", "text": "Decreased intra-hepatic levels of miR-@ were observed in patients with hepatocellular carcinoma , suggesting a potential role of miR-@ in the development of HCC .", "sentence_id": 1}
+{"abstract_id": "25218783", "label": "objective", "text": "Miravirsen targets miR-@ and resulted in a dose dependent and prolonged decrease of HCV RNA levels in chronic hepatitis C patients .", "sentence_id": 2}
+{"abstract_id": "25218783", "label": "objective", "text": "The aim of this study was to establish the sustained virological response rate to peginterferon ( P ) and ribavirin ( R ) following miravirsen dosing and to assess long-term safety in patients treated with miravirsen .", "sentence_id": 3}
+{"abstract_id": "25218783", "label": "methods", "text": "In this multicenter , retrospective follow-up study we included @ treatment nave patients with chronic hepatitis C genotype @ who received five weekly subcutaneous injections with miravirsen or placebo over a @-day period in a phase @a study .", "sentence_id": 4}
+{"abstract_id": "25218783", "label": "methods", "text": "Patients were offered PR therapy @weeks ( @mg/kg group ) or @weeks ( @ or @mg/kg group ) after completion of miravirsen or placebo dosing .", "sentence_id": 5}
+{"abstract_id": "25218783", "label": "results", "text": "PR therapy was started in @/@ patients of whom @ had received miravirsen .", "sentence_id": 6}
+{"abstract_id": "25218783", "label": "results", "text": "SVR was achieved in @/@ patients previously dosed with miravirsen .", "sentence_id": 7}
+{"abstract_id": "25218783", "label": "results", "text": "All patients dosed with @mg/kg miravirsen who were subsequently treated with PR achieved SVR .", "sentence_id": 8}
+{"abstract_id": "25218783", "label": "results", "text": "One patient had a prolonged undetectable HCV RNA period from week @ to week @ after baseline without subsequent antiviral therapy and relapsed thereafter .", "sentence_id": 9}
+{"abstract_id": "25218783", "label": "results", "text": "None of the patients treated with anti-miR-@ developed HCC or other liver-related complications .", "sentence_id": 10}
+{"abstract_id": "25218783", "label": "conclusions", "text": "No long-term safety issues were observed among @ miravirsen-treated patients .", "sentence_id": 11}
+{"abstract_id": "25218783", "label": "conclusions", "text": "Targeting miR-@ may be an effective and safe treatment strategy for HCV infection and should be investigated in larger clinical trials .", "sentence_id": 12}
+{"abstract_id": "25563311", "label": "background", "text": "The efficacy of montelukast ( MONT ) , a cysteinyl leukotriene receptor antagonist , in nonasthmatic eosinophilic bronchitis ( NAEB ) , especially its influence on cough associated life quality is still indefinite .", "sentence_id": 0}
+{"abstract_id": "25563311", "label": "background", "text": "We evaluated the efficacy of MONT combined with budesonide ( BUD ) as compared to BUD monotherapy in improving life quality , suppressing airway eosinophilia and cough remission in NAEB .", "sentence_id": 1}
+{"abstract_id": "25563311", "label": "methods", "text": "A prospective , open-labeled , multicenter , randomized controlled trial was conducted .", "sentence_id": 2}
+{"abstract_id": "25563311", "label": "methods", "text": "Patients with NAEB ( aged @-@ years ) were randomized to inhaled BUD ( @ g , bid ) or BUD plus oral MONT ( @ g , qn ) for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25563311", "label": "methods", "text": "Leicester cough questionnaire ( LCQ ) life quality scores , cough visual analog scale ( CVAS ) scores , eosinophil differential ratio ( Eos ) , and eosinophil cationic protein ( ECP ) in induced sputum were monitored and compared .", "sentence_id": 4}
+{"abstract_id": "25563311", "label": "results", "text": "The control and MONT groups contained @ and @ patients , respectively , with similar baseline characteristics .", "sentence_id": 5}
+{"abstract_id": "25563311", "label": "results", "text": "Significant with-in group improvement in CVAS , LCQ scores , Eos , and ECP was observed in both groups during treatment .", "sentence_id": 6}
+{"abstract_id": "25563311", "label": "results", "text": "After @-week treatment , add-on treatment of MONT was significantly more effective than BUD monotherapy for CVAS decrease and LCQ scores improvement ( both P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25563311", "label": "results", "text": "Similar results were seen at @-week assessment ( both P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25563311", "label": "results", "text": "@-week add-on therapy of MONT also resulted in a higher percentage of patients with normal sputum Eos ( < @ % ) and greater decrease of ECP ( both P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25563311", "label": "conclusions", "text": "MONT combined with BUD was demonstrated cooperative effects in improvement of life quality , suppression of eosinophilic inflammation , and cough remission in patients with NAEB .", "sentence_id": 10}
+{"abstract_id": "25668645", "label": "background", "text": "Adolescents living in South Africa are at high risk for HIV and other sexually transmitted diseases ( STDs ) .", "sentence_id": 0}
+{"abstract_id": "25668645", "label": "background", "text": "The present study sought to identify correlates of curable STD incidence among a cohort of adolescents in Eastern Cape Province , South Africa .", "sentence_id": 1}
+{"abstract_id": "25668645", "label": "methods", "text": "Data were collected in conjunction with an HIV/STD prevention intervention randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "25668645", "label": "methods", "text": "At @ months postintervention , curable STD incidence ( gonorrhea , chlamydial infection , and trichomoniasis ) was assayed and self-report measures of potential correlates of STD incidence were collected .", "sentence_id": 3}
+{"abstract_id": "25668645", "label": "results", "text": "Participants were adolescents reporting at least @ sexual partner in the past @ months ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25668645", "label": "results", "text": "As expected , univariate analyses revealed that girls were more likely than boys to have an STD .", "sentence_id": 5}
+{"abstract_id": "25668645", "label": "results", "text": "In addition , intimate partner violence , unprotected sex , and having older partners were associated with incident STD .", "sentence_id": 6}
+{"abstract_id": "25668645", "label": "results", "text": "In Poisson multiple regression analyses , sex ( risk ratio -LSB- RR -RSB- , @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ) , intimate partner violence ( RR , @ ; @ % CI , @-@ @ ) , unprotected sex ( RR , @ ; @ % CI , @-@ @ ) , and multiple partners ( RR , @ ; @ % CI , @-@ @ ) , but not partner 's age ( RR , @ ; @ % CI , @-@ @ ) were associated with incident STD , adjusting for @-month STD prevalence .", "sentence_id": 7}
+{"abstract_id": "25668645", "label": "results", "text": "Binge drinking , forced sex , and age were unrelated to STD incidence in both analyses .", "sentence_id": 8}
+{"abstract_id": "25668645", "label": "results", "text": "Interactions between sex and the hypothesized correlates were nonsignificant , suggesting that sex did not modify these relationships .", "sentence_id": 9}
+{"abstract_id": "25668645", "label": "conclusions", "text": "Interventions to reduce HIV/STD incidence among adolescents in South Africa should address the risk associated with sex , unprotected sex , intimate partner violence , and multiple partnerships .", "sentence_id": 10}
+{"abstract_id": "25306746", "label": "objective", "text": "To identify micronutrient deficiencies in patients with functional bowel diseases ( FBD ) and to reveal their correction with functional foods and probiotics .", "sentence_id": 0}
+{"abstract_id": "25306746", "label": "methods", "text": "The health status was evaluated in @ patients aged @ to @ years with FBD .", "sentence_id": 1}
+{"abstract_id": "25306746", "label": "methods", "text": "All the patients were randomized into @ groups according to the treatment regimen .", "sentence_id": 2}
+{"abstract_id": "25306746", "label": "methods", "text": "Group @ took Amaltea goat 's milk @ ml/day during basic therapy ; Group @ received multispecies and multistrain RioFlora Balance probiotics in addition to the above components ; Group @ ( a control group ) had traditional basic dietary therapy .", "sentence_id": 3}
+{"abstract_id": "25306746", "label": "methods", "text": "All the groups continued their treatment for @ days .", "sentence_id": 4}
+{"abstract_id": "25306746", "label": "results", "text": "The performed examinations have demonstrated that diet-based treatment fortified with goat 's milk and multispecies probiotics makes it possible to more promptly achieve remission and to level off clinical manifestations than in the control group .", "sentence_id": 5}
+{"abstract_id": "25306746", "label": "results", "text": "The patients using multispecies probiotics versus the control group showed a reduction in fat-soluble vitamin deficiencies and a considerable improvement in quality of life .", "sentence_id": 6}
+{"abstract_id": "25306746", "label": "conclusions", "text": "FBD lacks a specific clinical picture and may be masked as lactase deficiency , which commonly leads to noticeable limitations in patients ' diet and favors the development of vitamin deficiency .", "sentence_id": 7}
+{"abstract_id": "25306746", "label": "conclusions", "text": "Of particular concern is the development of vitamin D deficiency in young patients , which may result in the early development of osteoporosis in the future .", "sentence_id": 8}
+{"abstract_id": "25306746", "label": "conclusions", "text": "To specify the composition of enzymes in the patients gives grounds to refuse restricted diets , and the dietary addition of functional foods ( goat 's milk fortified with vitamins and minerals ) , particularly in combination with multistrain probiotics , produces a pronounced clinical effect and eliminates fat-soluble vitamin deficiencies .", "sentence_id": 9}
+{"abstract_id": "25965717", "label": "objective", "text": "We examined the effect of the renin inhibitor , aliskiren , on renal blood flow ( RBF ) in patients with heart failure with reduced ejection fraction ( HFREF ) and decreased glomerular filtration rate ( GFR ) .", "sentence_id": 0}
+{"abstract_id": "25965717", "label": "objective", "text": "Renal blood flow is the main determinant of GFR in HFREF patients .", "sentence_id": 1}
+{"abstract_id": "25965717", "label": "objective", "text": "Both reduced GFR and RBF are associated with increased mortality .", "sentence_id": 2}
+{"abstract_id": "25965717", "label": "objective", "text": "Aliskiren can provide additional renin-angiotensin-aldosterone system inhibition and increases RBF in healthy individuals .", "sentence_id": 3}
+{"abstract_id": "25965717", "label": "results", "text": "Patients with left ventricular ejection fraction @ % and estimated GFR @ to @ mL/min per @ m ( @ ) on optimal medical therapy were randomized @:@ to receive aliskiren @ mg once daily or placebo .", "sentence_id": 4}
+{"abstract_id": "25965717", "label": "results", "text": "Renal blood flow and GFR were measured using radioactive-labeled ( @ ) I-iothalamate and ( @ ) I-hippuran at baseline and @ weeks .", "sentence_id": 5}
+{"abstract_id": "25965717", "label": "results", "text": "After @ patients were included , the trial was halted based on an interim safety analysis showing futility .", "sentence_id": 6}
+{"abstract_id": "25965717", "label": "results", "text": "Mean age was @ @ years , @ % male , GFR ( @ @ mL/min per @ m ( @ ) ) , RBF ( @ @ mL/min per @ m ( @ ) ) , and NT-proBNP @ ( @-@ ) pg/mL .", "sentence_id": 7}
+{"abstract_id": "25965717", "label": "results", "text": "There was a nonsignificant change in RBF after @ weeks in the aliskiren group compared with placebo ( -@ @ vs +@ @ mL/min per @ m ( @ ) ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25965717", "label": "results", "text": "However , GFR decreased significantly in the aliskiren group compared with placebo ( -@ @ vs +@ @ mL/min per @ m ( @ ) ; P = @ ) as did filtration fraction ( -@ @ vs +@ @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25965717", "label": "results", "text": "There were no significant differences in plasma aldosterone , NT-proBNP , urinary tubular markers , or adverse events .", "sentence_id": 10}
+{"abstract_id": "25965717", "label": "results", "text": "Plasma renin activity was markedly reduced in the aliskiren group versus placebo throughout the treatment phase ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25965717", "label": "conclusions", "text": "Adding aliskiren on top of optimal HFREF medical therapy did not improve RBF and was associated with a reduction of GFR and filtration fraction .", "sentence_id": 12}
+{"abstract_id": "25466568", "label": "background", "text": "Coronary CT angiography ( CCTA ) has high sensitivity , with @ recent randomized trials favorably comparing CCTA to standard-of-care .", "sentence_id": 0}
+{"abstract_id": "25466568", "label": "background", "text": "Comparison to exercise stress ECG ( ExECG ) , the most available and least expensive standard-of-care worldwide , has not been systematically tested .", "sentence_id": 1}
+{"abstract_id": "25466568", "label": "methods", "text": "CT-COMPARE was a randomized , single-center trial of low-intermediate risk chest pain subjects undergoing CCTA or ExECG after the first negative troponin .", "sentence_id": 2}
+{"abstract_id": "25466568", "label": "methods", "text": "From March @ to April @ , @ patients randomized to either dual-source CCTA ( n = @ ) or ExECG ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25466568", "label": "methods", "text": "Primary endpoints were diagnostic performance for ACS , and hospital cost at @ days .", "sentence_id": 4}
+{"abstract_id": "25466568", "label": "methods", "text": "Secondary endpoints were time-to-discharge , admission rates , and downstream resource utilization .", "sentence_id": 5}
+{"abstract_id": "25466568", "label": "results", "text": "ACS occurred in @ ( @ % ) patients .", "sentence_id": 6}
+{"abstract_id": "25466568", "label": "results", "text": "ExECG had @ negative studies and @ ( @ % ) positive studies for ACS with sensitivity of @ % -LSB- @ % CI : @ , @ % -RSB- , specificity of @ % -LSB- CI : @ , @ % -RSB- , and ROC AUC of @ -LSB- CI : @ , @ -RSB- .", "sentence_id": 7}
+{"abstract_id": "25466568", "label": "results", "text": "CCTA ( > @ % stenosis considered positive ) had @ negative studies and @/@ ( @ % ) positive studies with a sensitivity of @ % -LSB- CI : @ , @ -RSB- , specificity of @ % -LSB- CI : @ , @ % -RSB- , and ROC of @ -LSB- CI : @ , @ ; p = @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "25466568", "label": "results", "text": "Despite CCTA having higher odds of downstream testing ( OR @ ) , @ day per-patient cost was significantly lower for CCTA ( $ @ vs $ @ , p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25466568", "label": "results", "text": "Length of stay for CCTA was significantly reduced ( @ h -LSB- @ % CI : @-@ @ -RSB- , ExECG @ h -LSB- @ % CI : @-@ @ -RSB- , p < @ ) , which drove the reduction in cost .", "sentence_id": 10}
+{"abstract_id": "25466568", "label": "results", "text": "No patient had post-discharge cardiovascular events at @ days .", "sentence_id": 11}
+{"abstract_id": "25466568", "label": "conclusions", "text": "CCTA had improved diagnostic performance compared to ExECG , combined with @ % relative reduction in length-of-stay , and @ % reduction in hospital costs .", "sentence_id": 12}
+{"abstract_id": "25466568", "label": "conclusions", "text": "These data lend further evidence that CCTA is useful as a first line assessment in emergency department chest pain .", "sentence_id": 13}
+{"abstract_id": "25591799", "label": "background", "text": "Tivozanib hydrochloride ( tivozanib ) is a potent and selective tyrosine kinase inhibitor of all @ vascular endothelial growth factor receptors with antitumor activity additive to @-fluorouracil in preclinical models .", "sentence_id": 0}
+{"abstract_id": "25591799", "label": "background", "text": "This study was conducted to determine maximum tolerated dose ( MTD ) , dose-limiting toxicities ( DLTs ) , pharmacokinetics ( PKs ) , and antitumor activity of escalating doses of tivozanib with a modified ( m ) FOLFOX-@ ( leucovorin , @-fluorouracil -LSB- @-FU -RSB- , and @ mg/kg ( @ ) oxaliplatin ) regimen in patients with advanced gastrointestinal tumors .", "sentence_id": 1}
+{"abstract_id": "25591799", "label": "methods", "text": "Tivozanib was administered orally once daily for @ days in @-day cycles , with mFOLFOX-@ administered every @ days .", "sentence_id": 2}
+{"abstract_id": "25591799", "label": "methods", "text": "Patients were allowed to continue tivozanib after discontinuation of mFOLFOX-@ .", "sentence_id": 3}
+{"abstract_id": "25591799", "label": "results", "text": "Thirty patients were assigned to tivozanib @ mg ( n = @ ) , @ mg ( n = @ ) , or @ mg ( n = @ ) with mFOLFOX-@ .", "sentence_id": 4}
+{"abstract_id": "25591799", "label": "results", "text": "Patients received a median of @ ( range , @-@ @ ) months of tivozanib .", "sentence_id": 5}
+{"abstract_id": "25591799", "label": "results", "text": "DLTs were observed in @ patients : Grade @/@ transaminase level increases with tivozanib @ mg , and Grade @ dizziness with tivozanib @ mg .", "sentence_id": 6}
+{"abstract_id": "25591799", "label": "results", "text": "Other Grade @/@ adverse events included hypertension ( n = @ ) , fatigue ( n = @ ) , and neutropenia ( n = @ ) .", "sentence_id": 7}
+{"abstract_id": "25591799", "label": "results", "text": "MTD for tivozanib with mFOLFOX-@ was confirmed as @ mg .", "sentence_id": 8}
+{"abstract_id": "25591799", "label": "results", "text": "No PK interactions between tivozanib and mFOLFOX-@ were observed .", "sentence_id": 9}
+{"abstract_id": "25591799", "label": "results", "text": "One patient had an ongoing clinical complete response , @ had a partial response , and @ obtained prolonged stable disease .", "sentence_id": 10}
+{"abstract_id": "25591799", "label": "conclusions", "text": "Tivozanib and mFOLFOX-@ is feasible and appears to be safe .", "sentence_id": 11}
+{"abstract_id": "25591799", "label": "conclusions", "text": "The recommended dose for tivozanib with mFOLFOX-@ is @ mg/d .", "sentence_id": 12}
+{"abstract_id": "25591799", "label": "conclusions", "text": "Observed clinical activity merits further exploration in gastrointestinal tumors .", "sentence_id": 13}
+{"abstract_id": "24977456", "label": "objective", "text": "Although adiposity has been considered to be protective against hot flashes , newer data suggest positive relationships between hot flashes and adiposity .", "sentence_id": 0}
+{"abstract_id": "24977456", "label": "objective", "text": "No studies have been specifically designed to test whether weight loss reduces hot flashes .", "sentence_id": 1}
+{"abstract_id": "24977456", "label": "objective", "text": "This pilot study aimed to evaluate the feasibility , acceptability , and initial efficacy of behavioral weight loss in reducing hot flashes .", "sentence_id": 2}
+{"abstract_id": "24977456", "label": "methods", "text": "Forty overweight or obese women with hot flashes ( @ hot flashes/d ) were randomized to either behavioral weight loss intervention or wait-list control .", "sentence_id": 3}
+{"abstract_id": "24977456", "label": "methods", "text": "Hot flashes were assessed before and after intervention via physiologic monitoring , diary , and questionnaire .", "sentence_id": 4}
+{"abstract_id": "24977456", "label": "methods", "text": "Comparisons of changes in hot flashes and anthropometrics between conditions were performed via Wilcoxon tests .", "sentence_id": 5}
+{"abstract_id": "24977456", "label": "results", "text": "Study retention ( @ % ) and intervention satisfaction ( @ % ) were high .", "sentence_id": 6}
+{"abstract_id": "24977456", "label": "results", "text": "Most women ( @ % ) reported that hot flash reduction was a major motivator for losing weight .", "sentence_id": 7}
+{"abstract_id": "24977456", "label": "results", "text": "Women randomized to the weight loss intervention lost more weight ( -@ kg ) than did women randomized to control ( +@ kg ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24977456", "label": "results", "text": "Women randomized to weight loss also showed greater reductions in questionnaire-reported hot flashes ( @-wk hot flashes , -@ ) than did women in the control group ( -@ ; P = @ ) - a difference not demonstrated in other hot flash measures .", "sentence_id": 9}
+{"abstract_id": "24977456", "label": "results", "text": "Reductions in weight and hot flashes were significantly correlated ( eg , r = @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24977456", "label": "conclusions", "text": "This pilot study shows a behavioral weight loss program that is feasible , acceptable , and effective in producing weight loss among overweight or obese women with hot flashes .", "sentence_id": 11}
+{"abstract_id": "24977456", "label": "conclusions", "text": "Findings indicate the importance of a larger study designed to test behavioral weight loss for hot flash reduction .", "sentence_id": 12}
+{"abstract_id": "24977456", "label": "conclusions", "text": "Hot flash management could motivate women to engage in this health-promoting behavior .", "sentence_id": 13}
+{"abstract_id": "25517820", "label": "methods", "text": "The bioavailability of rifampicin ( RMP ) decreases by @ % on interaction with isoniazid ( INH ) in stomach acid conditions , which can result in the development of drug resistance and treatment failure .", "sentence_id": 0}
+{"abstract_id": "25517820", "label": "objective", "text": "To compare the bioavailability in healthy volunteers of five anti-tuberculosis fixed-drug combinations ( FDCs ) used in China ( formulations A-E ) containing RMP and INH against single-drug formulations taken as reference .", "sentence_id": 1}
+{"abstract_id": "25517820", "label": "methods", "text": "Two - or three-period , two - or three-sequence crossover study of drugs .", "sentence_id": 2}
+{"abstract_id": "25517820", "label": "results", "text": "Only RMP formulation E passed the bioequivalence criteria , with @ % confidence intervals for the log-transformed ratios of AUC , AUC , and Cmax of respectively @-@ @ , @-@ @ and @-@ @ .", "sentence_id": 3}
+{"abstract_id": "25517820", "label": "results", "text": "For INH , formulations A , B , C and D passed the bioequivalence test , but not product E , where the @ % CIs of the log-transformed ratios of AUC , AUC , and Cmax were respectively @-@ @ , @-@ @ and @-@ @ .", "sentence_id": 4}
+{"abstract_id": "25517820", "label": "conclusions", "text": "According to the results of the bioequivalence analysis carried out in this study , RMP formulations A , B , C and D were not within the acceptable range and only formulation E passed the bioequivalence criteria of @-@ % .", "sentence_id": 5}
+{"abstract_id": "25517820", "label": "conclusions", "text": "In comparison , four-test INH formulations ( A , B , C and D ) were bioequivalent to the corresponding single-drug formulation , while product E failed in the bioequivalence criteria .", "sentence_id": 6}
+{"abstract_id": "25115507", "label": "objective", "text": "In athletes , caffeine use is common although its effects on sleep have not been widely studied .", "sentence_id": 0}
+{"abstract_id": "25115507", "label": "objective", "text": "This randomised , double-blind , placebo-controlled crossover trial investigated the effects of late-afternoon caffeine and carbohydrate-electrolyte ( CEB ) co-ingestion on cycling performance and nocturnal sleep .", "sentence_id": 1}
+{"abstract_id": "25115507", "label": "methods", "text": "Six male cyclists/triathletes ( age @ @ years ) completed an afternoon training session ( TS ; cycling @ min ; @ % VOmax ) followed by a @ kJ kg ( -@ ) cycling time trial ( TT ) .", "sentence_id": 2}
+{"abstract_id": "25115507", "label": "methods", "text": "Caffeine ( split dose @ @ mg kg ( -@ ) ) or placebo was administered @ h prior and @ min into the TS .", "sentence_id": 3}
+{"abstract_id": "25115507", "label": "methods", "text": "A @ % CEB ( @ ml kg ( -@ ) every @ min ) was administered during the TS , followed @ min after by a standardised evening meal .", "sentence_id": 4}
+{"abstract_id": "25115507", "label": "methods", "text": "Participants retired at their usual bedtime and indices of sleep duration and quality were monitored via polysomnography .", "sentence_id": 5}
+{"abstract_id": "25115507", "label": "methods", "text": "mean SD .", "sentence_id": 6}
+{"abstract_id": "25115507", "label": "results", "text": "All participants performed better in the caffeine TT ( caffeine @ @ ; placebo @ @ min ; p = @ ) , while ratings of perceived exertion ( caffeine @ @ ; placebo @ @ ; p = @ ) and heart rate ( caffeine @ @ ; placebo @ @ bpm ; p = @ ) were lower in the caffeine TS .", "sentence_id": 7}
+{"abstract_id": "25115507", "label": "results", "text": "Caffeine intake induced significant disruptions to a number of sleep indices including increased sleep onset latency ( caffeine @ @ ; placebo @ @ min ; p = @ ) and decreased sleep efficiency ( caffeine @ @ ; placebo @ @ % ; p = @ ) , rapid eye movement sleep ( caffeine @ @ ; placebo @ @ min ; p = @ ) and total sleep time ( caffeine @ @ ; placebo @ @ min ; p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25115507", "label": "conclusions", "text": "This study supports a performance-enhancing effect of caffeine , although athletes ( especially those using caffeine for late-afternoon/evening training and competition ) should consider its deleterious effects on sleep .", "sentence_id": 9}
+{"abstract_id": "25206295", "label": "objective", "text": "To study the effect of probiotic consumption on the faecal microbiota during and after antibiotic exposure .", "sentence_id": 0}
+{"abstract_id": "25206295", "label": "methods", "text": "A randomized , double-blind , placebo-controlled , parallel group study with a two species probiotic combination -LSB- Lactobacillus acidophilus ( L. acidophilus ) ATCC @ and Bifidobacterium lactis ( B. lactis ) ATCC SD@ -RSB- on healthy adults during and after antibiotic treatment ( amoxicillin @ and @ mg clavulanate ) .", "sentence_id": 1}
+{"abstract_id": "25206295", "label": "methods", "text": "The dominant faecal microbiota was studied by real time-polymerase chain reaction to determine if this probiotic preparation could facilitate restoring the microbiota to its pre-antibiotic state and influence the prevalence of beta-lactam resistance .", "sentence_id": 2}
+{"abstract_id": "25206295", "label": "methods", "text": "Gastrointestinal symptoms were recorded by questionnaire and Bristol stool scale .", "sentence_id": 3}
+{"abstract_id": "25206295", "label": "results", "text": "Subjects on the probiotic combination had significantly higher faecal counts of L. acidophilus ATCC @ and B. lactis at day @ ( end of antibiotic treatment period ) vs those on placebo .", "sentence_id": 4}
+{"abstract_id": "25206295", "label": "results", "text": "Furthermore , subjects on the probiotic combination had significantly higher faecal counts of L. acidophilus ATCC @ and B. lactis at Day @ ( end of probiotic treatment ) vs those on placebo .", "sentence_id": 5}
+{"abstract_id": "25206295", "label": "results", "text": "Lactobacillus counts remained stable in the probiotic group over the course of the study , while Clostridium XIV group was higher at the end of the study and closer to baseline levels ; this in contrast to the placebo group .", "sentence_id": 6}
+{"abstract_id": "25206295", "label": "results", "text": "Beta-lactam resistance in creased after antibiotic exposure and was not different between both treatment groups .", "sentence_id": 7}
+{"abstract_id": "25206295", "label": "results", "text": "Gastrointestinal symptoms were generally mild and did not differ between the treatment groups , which correlates with the generally small changes in the microbiota .", "sentence_id": 8}
+{"abstract_id": "25206295", "label": "conclusions", "text": "Consumption of the probiotic combination mainly leads to an increase in the faecal levels of the species included in the preparation .", "sentence_id": 9}
+{"abstract_id": "25862350", "label": "objective", "text": "Capecitabine and S-@ are orally administered fluorinated pyrimidines with high-level activity against metastatic breast cancer ( MBC ) .", "sentence_id": 0}
+{"abstract_id": "25862350", "label": "objective", "text": "This randomized , multicenter , phase II study compared the activities and safeties of the oral fluoropyrimidines , capecitabine and S-@ , in breast cancer patients .", "sentence_id": 1}
+{"abstract_id": "25862350", "label": "methods", "text": "Patients with MBC were randomly assigned to receive capecitabine @g/m ( @ ) twice daily on days @-@ every @weeks or S-@ @-@mg twice daily , according to body surface area , on days @-@ every @weeks .", "sentence_id": 2}
+{"abstract_id": "25862350", "label": "methods", "text": "The primary endpoint was progression-free survival ( PFS ) .", "sentence_id": 3}
+{"abstract_id": "25862350", "label": "results", "text": "A total of @ patients were enrolled and randomized to either capecitabine ( N = @ ) or S-@ ( N = @ ) .", "sentence_id": 4}
+{"abstract_id": "25862350", "label": "results", "text": "Median PFS ( progression-free survival ) was @ years for capecitabine and @ years for S-@ , with a hazard ratio ( S-@ / capecitabine ) of @ ( @ % confidence interval -LSB- CI -RSB- @-@ @ ) ( P = @ by log-rank ) .", "sentence_id": 5}
+{"abstract_id": "25862350", "label": "results", "text": "The confirmed objective response rates were @ % for capecitabine and @ % for S-@ ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25862350", "label": "results", "text": "The most common treatment-related adverse events were grade @-@ in intensity .", "sentence_id": 7}
+{"abstract_id": "25862350", "label": "results", "text": "Thrombocytopenia ( S-@ : @ % , capecitabine : @ % ; P = @ ) and nausea ( S-@ : @ % , capecitabine : @ % ; P = @ ) were more frequent in the S-@ group , while hand-foot syndrome occurred more often in the capecitabine group ( S-@ : @ % , capecitabine : @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25862350", "label": "conclusions", "text": "The results of the current study demonstrate that both S-@ and capecitabine are effective and well-tolerated treatments in patients with MBC , while their adverse events were different .", "sentence_id": 9}
+{"abstract_id": "25862350", "label": "conclusions", "text": "They are both convenient , orally administered drugs , making them attractive agents for use in outpatient treatment .", "sentence_id": 10}
+{"abstract_id": "25057153", "label": "background", "text": "Estimates of energy intake ( EI ) in humans have limited validity .", "sentence_id": 0}
+{"abstract_id": "25057153", "label": "objective", "text": "The objective was to test the accuracy and precision of the intake-balance method to estimate EI during weight gain induced by overfeeding .", "sentence_id": 1}
+{"abstract_id": "25057153", "label": "methods", "text": "In @ studies of controlled overfeeding ( @ inpatient study and @ outpatient study ) , baseline energy requirements were determined by a doubly labeled water study and caloric titration to weight maintenance .", "sentence_id": 2}
+{"abstract_id": "25057153", "label": "methods", "text": "Overfeeding was prescribed as @ % of baseline energy requirements for @ d. Changes in weight , fat mass ( FM ) , and fat-free mass ( FFM ) were used to estimate change in energy stores ( ES ) .", "sentence_id": 3}
+{"abstract_id": "25057153", "label": "methods", "text": "Overfeeding EI was estimated as the sum of baseline energy requirements , thermic effect of food , and ES .", "sentence_id": 4}
+{"abstract_id": "25057153", "label": "methods", "text": "The estimated overfeeding EI was then compared with the actual EI consumed in the metabolic chamber during the last week of overfeeding .", "sentence_id": 5}
+{"abstract_id": "25057153", "label": "results", "text": "In inpatient individuals , calculated EI during overfeeding determined from ES in FM and FFM was ( mean SD ) @ @ kcal/d , which was not significantly ( -@ @ kcal/d or @ % ; limits of agreement : -@ , @ kcal/d ; P = @ ) different from the actual EI provided ( @ @ kcal/d ) .", "sentence_id": 6}
+{"abstract_id": "25057153", "label": "results", "text": "Estimated EI determined from ES in weight closely estimated actual intake ( -@ @ kcal/d or @ % ; limits of agreement : -@ , @ kcal/d ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25057153", "label": "results", "text": "In free-living individuals , estimated EI during overfeeding determined from ES in FM and FFM was @ @ kcal/d and underestimated actual EI ( @ @ kcal/d ; -@ @ kcal or @ % ; limits of agreement : -@ , @ kcal/d ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25057153", "label": "results", "text": "Estimated EI determined from ES in weight also underestimated actual intake ( -@ @ kcal/d or @ % ; limits of agreement : -@ , @ kcal/d ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25057153", "label": "conclusions", "text": "The intake-balance method can be used to estimate EI during a period of weight gain as a result of @ % overfeeding in individuals who are inpatients or free-living with only a slight underestimate of actual EI by @-@ @ % .", "sentence_id": 10}
+{"abstract_id": "24895878", "label": "objective", "text": "To use baseline computed tomographic ( CT ) angiography to analyze imaging and clinical end points in an Interventional Management of Stroke III cohort to identify patients who would benefit from endovascular stroke therapy .", "sentence_id": 0}
+{"abstract_id": "24895878", "label": "methods", "text": "The primary clinical end point was @-day dichotomized modified Rankin Scale ( mRS ) score .", "sentence_id": 1}
+{"abstract_id": "24895878", "label": "methods", "text": "Secondary end points were @-day mRS score distribution and @-hour recanalization .", "sentence_id": 2}
+{"abstract_id": "24895878", "label": "methods", "text": "Prespecified subgroup was baseline proximal occlusions ( internal carotid , M@ , or basilar arteries ) .", "sentence_id": 3}
+{"abstract_id": "24895878", "label": "methods", "text": "Exploratory analyses were subsets with any occlusion and specific sites of occlusion ( two-sided = @ ) .", "sentence_id": 4}
+{"abstract_id": "24895878", "label": "results", "text": "Of @ subjects , @ ( @ % ) underwent baseline CT angiography or magnetic resonance angiography .", "sentence_id": 5}
+{"abstract_id": "24895878", "label": "results", "text": "Of @ , @ ( @ % ) had arterial occlusions .", "sentence_id": 6}
+{"abstract_id": "24895878", "label": "results", "text": "At baseline CT angiography , proximal occlusions ( n = @ ) demonstrated no difference in primary outcome ( @ % -LSB- @ of @ -RSB- endovascular vs @ % -LSB- @ of @ -RSB- intravenous -LSB- IV -RSB- tissue-plasminogen activator -LSB- tPA -RSB- ; relative risk , @ -LSB- @ % confidence interval : @ , @ -RSB- ; P = @ ) ; however , @-hour recanalization rate was higher for endovascular treatment ( n = @ ; @ % -LSB- @ of @ -RSB- endovascular vs @ % -LSB- @ of @ -RSB- IV tPA ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24895878", "label": "results", "text": "Exploratory subgroup analysis for any occlusion at baseline CT angiography did not demonstrate significant differences between endovascular and IV tPA arms for primary outcome ( @ % -LSB- @ of @ -RSB- vs @ % -LSB- @ of @ -RSB- , P = @ ) , although ordinal shift analysis of full mRS distribution demonstrated a trend toward more favorable outcome ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24895878", "label": "results", "text": "Carotid T - or L-type occlusion ( terminal internal carotid artery -LSB- ICA -RSB- with M@ middle cerebral artery and/or A@ anterior cerebral artery involvement ) or tandem ( extracranial or intracranial ) ICA and M@ occlusion subgroup also showed a trend favoring endovascular treatment over IV tPA alone for primary outcome ( @ % -LSB- @ of @ -RSB- vs @ % -LSB- one of @ -RSB- , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24895878", "label": "conclusions", "text": "Significant differences were identified between treatment arms for @-hour recanalization in proximal occlusions ; carotid T - or L-type and tandem ICA and M@ occlusions showed greater recanalization and a trend toward better outcome with endovascular treatment .", "sentence_id": 10}
+{"abstract_id": "24895878", "label": "conclusions", "text": "Vascular imaging should be mandated in future endovascular trials to identify such occlusions .", "sentence_id": 11}
+{"abstract_id": "24895878", "label": "conclusions", "text": "Online supplemental material is available for this article .", "sentence_id": 12}
+{"abstract_id": "24461523", "label": "objective", "text": "To investigate the potential antioxidant effects of Phyllanthus niruri ( P. niruri , Euphorbiaceae ) tea on healthy subjects .", "sentence_id": 0}
+{"abstract_id": "24461523", "label": "methods", "text": "Five non-smoking , male healthy volunteers , @ to @ years old , were enrolled .", "sentence_id": 1}
+{"abstract_id": "24461523", "label": "methods", "text": "Each subject was treated twice , following a randomized crossover fashion regarding the ingestion of P. niruri infusion ( @ g/@ mL ) ( tea group ) or @ mL of water ( control group ) .", "sentence_id": 2}
+{"abstract_id": "24461523", "label": "methods", "text": "Fasting venous blood samples were collected prior to and at @ , @ and @ h after infusion drinking .", "sentence_id": 3}
+{"abstract_id": "24461523", "label": "methods", "text": "Samples were tested for plasmatic gallic acid and ascorbic acid levels , erythrocytic catalase and superoxide dismutase activities , and intracellular DCFH fluorescence in granulocytes , monocytes and lymphocytes .", "sentence_id": 4}
+{"abstract_id": "24461523", "label": "results", "text": "Catalase and superoxide dismutase activities were not altered by tea ingestion .", "sentence_id": 5}
+{"abstract_id": "24461523", "label": "results", "text": "Plasma levels of gallic acid were significantly increased at @ , @ and @ h after P. niruri ingestion and plasma ascorbic acid at @ h after P. niruri ingestion .", "sentence_id": 6}
+{"abstract_id": "24461523", "label": "conclusions", "text": "Ingestion of P. niruri tea is associated with a slight increase in antioxidant markers in human blood ( ascorbic acid and gallic acid ) , which may contribute to its pharmacological effects .", "sentence_id": 7}
+{"abstract_id": "24337078", "label": "background", "text": "Black box warnings for young adults under the age of @ years indicate that antidepressants may increase risk of suicide .", "sentence_id": 0}
+{"abstract_id": "24337078", "label": "background", "text": "While underlying mechanisms for age-related treatment effects remain unclear , vagally mediated cardiovascular function may play a key role .", "sentence_id": 1}
+{"abstract_id": "24337078", "label": "background", "text": "Decreased heart rate ( HR ) and an increase in its variability ( HRV ) improve one 's capacity to adapt to environmental stress and attenuate risk for suicide .", "sentence_id": 2}
+{"abstract_id": "24337078", "label": "objective", "text": "Using a double blind , randomized , placebo-controlled , crossover , experimental study , we examine whether a single dose of escitalopram ( @ mg ) attenuates cardiovascular responses to stress under experimental conditions and determine whether age moderates these effects .", "sentence_id": 3}
+{"abstract_id": "24337078", "label": "methods", "text": "Forty-four healthy females received a single dose of escitalopram ( @ mg ) and placebo treatment separated by a @-week interval ( > @ half-lives ) .", "sentence_id": 4}
+{"abstract_id": "24337078", "label": "methods", "text": "HR and high frequency HRV ( HF HRV normalized units ; @-@ @ Hz ) were measured during resting state and stress .", "sentence_id": 5}
+{"abstract_id": "24337078", "label": "results", "text": "While escitalopram attenuated the increase in HR and increased HF HRV , these moderate to large effects were only significant in participants over @ years of age .", "sentence_id": 6}
+{"abstract_id": "24337078", "label": "results", "text": "No beneficial cardiovascular effects of escitalopram were observed in those under the age of @ .", "sentence_id": 7}
+{"abstract_id": "24337078", "label": "conclusions", "text": "Maturational differences in the development of the prefrontal cortex -- a critical region in the central network of autonomic control -- may underpin these differential findings .", "sentence_id": 8}
+{"abstract_id": "24337078", "label": "conclusions", "text": "This study provides a theoretical framework on which future research on treatment-emergent suicidality in clinical populations could be based .", "sentence_id": 9}
+{"abstract_id": "24671361", "label": "objective", "text": "Clinical decision support has the potential to improve prevention of venous thromboembolism ( VTE ) .", "sentence_id": 0}
+{"abstract_id": "24671361", "label": "objective", "text": "The purpose of this prospective study was to analyze the effect of electronic reminders on thromboprophylaxis rates in wards to which patients were admitted and transferred .", "sentence_id": 1}
+{"abstract_id": "24671361", "label": "objective", "text": "The latter was of particular interest since patient handoffs are considered to be critical safety issues .", "sentence_id": 2}
+{"abstract_id": "24671361", "label": "methods", "text": "The trial involved two study periods in the six departments of a university hospital , three of which were randomly assigned to the intervention group displaying reminders during the second period .", "sentence_id": 3}
+{"abstract_id": "24671361", "label": "methods", "text": "At @h after admission or transfer , the algorithm checked for prophylaxis orders within @-@h of the patient 's arrival , increasing the specificity of the displayed reminders .", "sentence_id": 4}
+{"abstract_id": "24671361", "label": "results", "text": "The significant impact of the reminders could be seen by prophylaxis orders placed @-@h after admission ( increasing from @ % ( @/@ ) to @ % ( @/@ ) ; p < @ ) and transfer ( increasing from @ % ( @/@ ) to @ % ( @/@ ) ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24671361", "label": "results", "text": "In admission wards , the rate of thromboprophylaxis increased from @ % to @ % ( p < @ ) , and in transfer wards it increased from @ % to @ % ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24671361", "label": "results", "text": "Overall , the rate of prophylaxis significantly increased in the intervention group from @ % to @ % ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24671361", "label": "results", "text": "No significant changes were observed in the control group .", "sentence_id": 8}
+{"abstract_id": "24671361", "label": "results", "text": "Postponing prophylaxis checks to @h after admissions and transfers reduced the number of reminders by @ % and thereby minimized the risk of alert fatigue .", "sentence_id": 9}
+{"abstract_id": "24671361", "label": "conclusions", "text": "The reminders improved awareness of VTE prevention in both admission and transfer wards .", "sentence_id": 10}
+{"abstract_id": "24671361", "label": "conclusions", "text": "This approach may contribute to better quality of care and safer patient handoffs .", "sentence_id": 11}
+{"abstract_id": "25280408", "label": "objective", "text": "The aim of this study was to evaluate the effect of carbohydrate or glutamine supplementation , or a combination of the two , on the immune system and inflammatory parameters after exercise in simulated hypoxic conditions at @ m.", "sentence_id": 0}
+{"abstract_id": "25280408", "label": "methods", "text": "Nine men underwent three sessions of exercise at @ % VO@peak until exhaustion as follows : @ ) hypoxia with a placebo ; @ ) hypoxia with @ % maltodextrin ( @ mL/@ min ) during exercise and for @ h after ; and @ ) hypoxia after @ d of glutamine supplementation ( @ g/d ) and supplementation with @ % maltodextrin ( @ mL/@ min ) during exercise and for @ h after .", "sentence_id": 1}
+{"abstract_id": "25280408", "label": "methods", "text": "All procedures were randomized and double blind .", "sentence_id": 2}
+{"abstract_id": "25280408", "label": "methods", "text": "Blood was collected at rest , immediately before exercise , after the completion of exercise , and @ h after recovery .", "sentence_id": 3}
+{"abstract_id": "25280408", "label": "methods", "text": "Glutamine , cortisol , cytokines , glucose , heat shock protein-@ , and erythropoietin were measured in serum , and the cytokine production from lymphocytes was measured .", "sentence_id": 4}
+{"abstract_id": "25280408", "label": "results", "text": "Erythropoietin and interleukin ( IL ) -@ increased after exercise in the hypoxia group compared with baseline .", "sentence_id": 5}
+{"abstract_id": "25280408", "label": "results", "text": "IL-@ was higher in the hypoxia group than pre-exercise after exercise and after @ h recovery .", "sentence_id": 6}
+{"abstract_id": "25280408", "label": "results", "text": "Cortisol did not change , whereas glucose was elevated post-exercise in the three groups compared with baseline and pre-exercise .", "sentence_id": 7}
+{"abstract_id": "25280408", "label": "results", "text": "Glutamine increased in the hypoxia + carbohydrate + glutamine group after exercise compared with baseline .", "sentence_id": 8}
+{"abstract_id": "25280408", "label": "results", "text": "Heat shock protein-@ increased post-exercise compared with baseline and pre-exercise and after recovery compared with pre-exercise , in the hypoxia + carbohydrate group .", "sentence_id": 9}
+{"abstract_id": "25280408", "label": "results", "text": "No difference was observed in IL-@ and IL-@ production from lymphocytes .", "sentence_id": 10}
+{"abstract_id": "25280408", "label": "results", "text": "IL-@ was reduced in the supplemented groups .", "sentence_id": 11}
+{"abstract_id": "25280408", "label": "conclusions", "text": "Carbohydrate or glutamine supplementation shifts the T helper ( Th ) @/Th@ balance toward Th@ responses after exercise at a simulated altitude of @ m.", "sentence_id": 12}
+{"abstract_id": "25280408", "label": "conclusions", "text": "The nutritional strategies increased in IL-@ , suggesting an important anti-inflammatory effect .", "sentence_id": 13}
+{"abstract_id": "25532604", "label": "background", "text": "In @ , Ethicon Inc. introduced a new minimally invasive single incision sling device for the surgical treatment of stress urinary incontinence , the Gynecare TVT Secur .", "sentence_id": 0}
+{"abstract_id": "25532604", "label": "background", "text": "For device licensing , no new evidence of TVT Secur efficacy and safety was needed : rather evidence was provided of the long-term follow-up of patients who had a procedure using a predecate retropubic tension-free vaginal tape device .", "sentence_id": 1}
+{"abstract_id": "25532604", "label": "background", "text": "Before adopting TVT Secur into our routine clinical practice , we decided to evaluate it .", "sentence_id": 2}
+{"abstract_id": "25532604", "label": "background", "text": "The objective of our Canadian multi-centre pragmatic randomized controlled trial was to compare the effectiveness of the new single-incision device , TVT Secur , to the established TVT device , in terms of objective cure of stress urinary incontinence ( SUI ) at @ months postoperatively .", "sentence_id": 3}
+{"abstract_id": "25532604", "label": "background", "text": "Other outcomes included : complications , symptoms , and incontinence-related quality of life .", "sentence_id": 4}
+{"abstract_id": "25532604", "label": "results", "text": "The sample size estimate for our trial was @ , but the trial stopped early because of poor recruitment .", "sentence_id": 5}
+{"abstract_id": "25532604", "label": "results", "text": "@ women participated ( @ allocated to TVT Secur , @ to TVT ) .", "sentence_id": 6}
+{"abstract_id": "25532604", "label": "results", "text": "At @ months postoperatively , @/@ ( @ % ) of TVT Secur group were cured , compared with @/@ ( @ % ) of the TVT group ( relative risk @ , @ % confidence interval @ to @ , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25532604", "label": "results", "text": "Most women reported little or no SUI symptoms ( @/@ ( @ % ) vs @/@ ( @ % ) , > @ ) .", "sentence_id": 8}
+{"abstract_id": "25532604", "label": "results", "text": "Quality of life improved significantly from baseline for both groups ( IIQ-@ mean change -@ for both groups ) but did not differ between groups ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25532604", "label": "conclusions", "text": "Our small randomized trial did not find statistically significant differences in outcomes between women allocated to the TVT Secur device versus those allocated to the TVT device for stress urinary incontinence .", "sentence_id": 10}
+{"abstract_id": "25532604", "label": "conclusions", "text": "Despite the discontinuation of TVT Secur in March @ for commercial reasons , the importance of our study lies in making evidence available for the many women who had a TVT Secur device implanted and their physicians who may be considering alternative treatments .", "sentence_id": 11}
+{"abstract_id": "25532604", "label": "conclusions", "text": "Our experience illustrates the difficulty of undertaking research on new licensed devices in a rapidly changing surgical specialty , and further highlights the need for research before licensing if surgeons and their patients are to be confident in the effectiveness and safety of new surgical devices .", "sentence_id": 12}
+{"abstract_id": "24438460", "label": "background", "text": "Prevention of alcohol , drug and tobacco misuse by young people is a key public health priority .", "sentence_id": 0}
+{"abstract_id": "24438460", "label": "background", "text": "There is a need to develop the evidence base through rigorous evaluations of innovative approaches to substance misuse prevention .", "sentence_id": 1}
+{"abstract_id": "24438460", "label": "background", "text": "The Strengthening Families Programme @-@ is a universal family-based alcohol , drugs and tobacco prevention programme , which has achieved promising results in US trials , and which now requires cross-cultural assessment .", "sentence_id": 2}
+{"abstract_id": "24438460", "label": "background", "text": "This paper therefore describes the protocol for a randomised controlled trial of the UK version of the Strengthening Families Programme @-@ ( SFP @-@ UK ) .", "sentence_id": 3}
+{"abstract_id": "24438460", "label": "methods", "text": "The trial comprises a pragmatic cluster randomised controlled effectiveness trial with families as the unit of randomisation , with embedded process and economic evaluations .", "sentence_id": 4}
+{"abstract_id": "24438460", "label": "methods", "text": "Participating families will be randomised to one of two treatment groups - usual care with full access to existing services ( control group ) , or usual care plus SFP @-@ UK ( intervention group ) .", "sentence_id": 5}
+{"abstract_id": "24438460", "label": "methods", "text": "The trial has two primary outcomes - the number of occasions that young people report having drunk alcohol in the last @ days , and drunkenness during the last @ days , both dichotomised as ` never ' and ' @-@ times or more ' .", "sentence_id": 6}
+{"abstract_id": "24438460", "label": "methods", "text": "The main follow-up is at @ years past baseline , and short-term and intermediate outcomes are also measured at @ and @ months .", "sentence_id": 7}
+{"abstract_id": "24438460", "label": "conclusions", "text": "The results from this trial will provide evidence on the effectiveness and cost-effectiveness of an innovative universal family-based substance misuse prevention programme in a UK context .", "sentence_id": 8}
+{"abstract_id": "24374539", "label": "objective", "text": "To investigate the effect that complications have on patients ' long-term quality of life ( QoL ) after curative colorectal cancer surgery .", "sentence_id": 0}
+{"abstract_id": "24374539", "label": "background", "text": "Colorectal cancer surgery is a high risk , with approximately @ in @ patients suffering a complication .", "sentence_id": 1}
+{"abstract_id": "24374539", "label": "background", "text": "The long-term consequences of postoperative complications are important but have poorly been documented .", "sentence_id": 2}
+{"abstract_id": "24374539", "label": "methods", "text": "The MRC-CLASICC trial ( laparoscopic-assisted vs open surgery for colorectal cancer ) included prospective evaluation of QoL using validated scoring questionnaires : EORTC QLQ-C@ / CR@ and EQ@D .", "sentence_id": 3}
+{"abstract_id": "24374539", "label": "methods", "text": "These were used to compare QoL at @ , @ , @ , and @ months to baseline values for patients categorized into @ groups : ( i ) those suffering any complication and ( ii ) those suffering any of @ common complications ( wound , chest , anastomotic leak , hemorrhage , and cardiac event ) .", "sentence_id": 4}
+{"abstract_id": "24374539", "label": "results", "text": "A total of @ of @ CLASICC patients were suitable for inclusion .", "sentence_id": 5}
+{"abstract_id": "24374539", "label": "results", "text": "Complications occurred in @ ( @ % ) patients , including : wound complications ( @ , @ % ) , chest infection ( @ , @ % ) , anastomotic leak ( @ , @ % ) , hemorrhage ( @ , @ % ) , and cardiac event ( @ , @ % ) .", "sentence_id": 6}
+{"abstract_id": "24374539", "label": "results", "text": "Significant long-term differences in QoL between patients with and without complications were found for Physical and Social Function , Role Functioning , and Body Image on EORTC QLQ-C@ / QLQ-CR@ analysis and Mobility , Self-care , and Pain/Discomfort on EQ@D analysis .", "sentence_id": 7}
+{"abstract_id": "24374539", "label": "results", "text": "No significant differences were seen for emotional/cognitive functioning , global QoL , financial difficulties , or future perspectives .", "sentence_id": 8}
+{"abstract_id": "24374539", "label": "results", "text": "Risk factors of age , gender , ASA ( American Society of Anesthesiologists ) grade , and stoma moderated the impact of complications in the short - to medium-term QoL , but had less influence on long-term QoL .", "sentence_id": 9}
+{"abstract_id": "24374539", "label": "conclusions", "text": "Postoperative complications have adverse effects on long-term QoL , particularly for Physical , Role and Social Functioning , and Body Image , as well as for Mobility , Self-care , and Pain/Discomfort .", "sentence_id": 10}
+{"abstract_id": "24374539", "label": "conclusions", "text": "These findings should inform future preoperative counseling and health care planning .", "sentence_id": 11}
+{"abstract_id": "25464260", "label": "objective", "text": "Recent data indicate that hypertension is not well controlled in many populations throughout the world .", "sentence_id": 0}
+{"abstract_id": "25464260", "label": "objective", "text": "The factors that influence individual response to anti-hypertensive treatment need to be clarified .", "sentence_id": 1}
+{"abstract_id": "25464260", "label": "objective", "text": "Pulse wave velocity ( PWV ) , as a marker of arterial stiffness , has been demonstrated to have important relationships with BP progression ; however , little information is available on the role of PWV in blood pressure ( BP ) control .", "sentence_id": 2}
+{"abstract_id": "25464260", "label": "objective", "text": "We aimed to assess BP control during the run-in treatment period in the China Stroke Primary Prevention Trial ( CSPPT ) .", "sentence_id": 3}
+{"abstract_id": "25464260", "label": "results", "text": "These analyses included a total of @ treated hypertensive subjects ( age : @ years , male/female @/@ ) with PWV measured at baseline .", "sentence_id": 4}
+{"abstract_id": "25464260", "label": "results", "text": "The average BP at enrollment was @/@mmHg , and declined to @/@mmHg after short-term antihypertensive treatment ( a median follow-up of @days ) .", "sentence_id": 5}
+{"abstract_id": "25464260", "label": "results", "text": "There was an inverse relationship between PWV level and BP reduction during the treatment , most notably for systolic BP ( with estimated coefficients of -@ ( P < @ ) for the top quartile , as compared to the bottom quartile ) .", "sentence_id": 6}
+{"abstract_id": "25464260", "label": "results", "text": "The association did not differ significantly by gender or types of antihypertensive drugs .", "sentence_id": 7}
+{"abstract_id": "25464260", "label": "results", "text": "Factors related to smaller BP decline were low baseline BP , high baseline PWV , high body mass index , high creatinine , use of fewer types of antihypertensive drug , high heart rate ( only for SBP ) , high homocysteine and low age ( only for DBP ) .", "sentence_id": 8}
+{"abstract_id": "25464260", "label": "conclusions", "text": "PWV appears to be an independent determinant of individual response to anti-hypertensive treatment .", "sentence_id": 9}
+{"abstract_id": "24580023", "label": "objective", "text": "To determine long-term safety and efficacy of adjunctive clobazam for patients with Lennox-Gastaut syndrome ( LGS ) .", "sentence_id": 0}
+{"abstract_id": "24580023", "label": "methods", "text": "Eligible patients from two randomized controlled trials ( Phase II OV-@ and Phase III OV-@ ) were able to enroll in open-label extension ( OLE ) study OV-@ beginning in December @ and received clobazam until they discontinued ( mandatory at @years for patients outside the United States ) or until study completion in March @ .", "sentence_id": 1}
+{"abstract_id": "24580023", "label": "methods", "text": "Patients in the United States could have received clobazam for @years before it became commercially available .", "sentence_id": 2}
+{"abstract_id": "24580023", "label": "methods", "text": "Efficacy assessments included changes in rates of drop seizures and total seizures , responder rates ( @ % , @ % , or @ % decreases in seizure frequency vs. baseline ) , sustained efficacy over time , concomitant antiepileptic drug ( AED ) use , and global evaluations .", "sentence_id": 3}
+{"abstract_id": "24580023", "label": "methods", "text": "Safety assessments included exposure to clobazam , laboratory assessments , physical and neurologic examinations , vital sign monitoring , electrocardiography monitoring , and adverse event reporting .", "sentence_id": 4}
+{"abstract_id": "24580023", "label": "results", "text": "Of @ patients who enrolled in the OLE , @ ( @ % ) completed the trial .", "sentence_id": 5}
+{"abstract_id": "24580023", "label": "results", "text": "Two hundred seven patients were from the United States , which was the only country in which patients could be treated with clobazam for > @years .", "sentence_id": 6}
+{"abstract_id": "24580023", "label": "results", "text": "Forty-four patients were treated with clobazam for @years , and @ for @years .", "sentence_id": 7}
+{"abstract_id": "24580023", "label": "results", "text": "Because of the low number of Year @ patients , this group is not reported separately .", "sentence_id": 8}
+{"abstract_id": "24580023", "label": "results", "text": "Improvements in baseline seizure rates were very stable over the course of the study , with a median @ % decrease in drop seizures at Year @ , @ % at Year @ , @ % at Year @ , @ % at Year @ , and a @ % decrease for patients who had reached Year @ .", "sentence_id": 9}
+{"abstract_id": "24580023", "label": "results", "text": "Similar results were observed for total seizures ( @ % decrease at both Years @ and @ , @ % decrease at Year @ , @ % decrease at Year @ , and @ % decrease at Year @ ) .", "sentence_id": 10}
+{"abstract_id": "24580023", "label": "results", "text": "Responder rates were also stable for the duration of the trial .", "sentence_id": 11}
+{"abstract_id": "24580023", "label": "results", "text": "Of patients who had achieved a @ % decrease in median drop-seizure frequency from baseline to Month @ , @ % still had that degree of drop-seizure reduction at Year @ ( and @ % lost their initial responses ) , and @ % were drop-seizure-free .", "sentence_id": 12}
+{"abstract_id": "24580023", "label": "results", "text": "Most patients who had achieved drop-seizure freedom in the original controlled trials remained drop-seizure-free in the OLE .", "sentence_id": 13}
+{"abstract_id": "24580023", "label": "results", "text": "Based on parents ' and physicians ' ratings of global evaluations , @ % of patients were `` very much improved '' or `` much improved '' after @years .", "sentence_id": 14}
+{"abstract_id": "24580023", "label": "results", "text": "Of the @ patients with concomitant AED data who were treated for @years , @ % increased , @ % decreased , and @ % had no change in numbers of AEDs versus their Week @ regimens .", "sentence_id": 15}
+{"abstract_id": "24580023", "label": "results", "text": "The mean modal clobazam dosage was @ mg/kg/day at Year @ and @ mg/kg/day at Year @ , suggesting that study patients did not need significant increases in dosage over time .", "sentence_id": 16}
+{"abstract_id": "24580023", "label": "results", "text": "The safety profile was what would be expected for clobazam for LGS patients over a @-year span , and no new safety concerns developed over time .", "sentence_id": 17}
+{"abstract_id": "24580023", "label": "conclusions", "text": "In this largest and longest-running trial in LGS , adjunctive clobazam sustained seizure freedom and substantial seizure improvements at stable dosages through @years of therapy in this difficult - to-treat patient population .", "sentence_id": 18}
+{"abstract_id": "24580023", "label": "conclusions", "text": "A PowerPoint slide summarizing this article is available for download in the Supporting Information section here .", "sentence_id": 19}
+{"abstract_id": "24261547", "label": "background", "text": "Limited capacity for social engagement is a core feature of autism spectrum disorder ( ASD ) , often evident early in the child 's development .", "sentence_id": 0}
+{"abstract_id": "24261547", "label": "background", "text": "While these skills are difficult to train , there is some evidence that active involvement in music-making provides unique opportunities for social interaction between participants .", "sentence_id": 1}
+{"abstract_id": "24261547", "label": "background", "text": "Family-centred music therapy ( FCMT ) endeavours to support social engagement between child and parent within active music-making , yet the extent of benefits provided is unknown .", "sentence_id": 2}
+{"abstract_id": "24261547", "label": "objective", "text": "This study investigated the impacts of FCMT on social engagement abilities .", "sentence_id": 3}
+{"abstract_id": "24261547", "label": "methods", "text": "Twenty-three children ( @-@ months ) with severe ASD received either @ weeks of FCMT in addition to their early intervention programmes ( n = @ ) , or their early intervention programme only ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24261547", "label": "methods", "text": "Change in social engagement was measured with standardized parent-report assessments , parent interviews and clinician observation .", "sentence_id": 5}
+{"abstract_id": "24261547", "label": "results", "text": "Intention-to-treat analysis for the Vineland Social Emotional Early Childhood Scale indicated a significant effect in favour of FCMT .", "sentence_id": 6}
+{"abstract_id": "24261547", "label": "results", "text": "Thematic qualitative analysis of the parent interviews showed that the parent-child relationship grew stronger .", "sentence_id": 7}
+{"abstract_id": "24261547", "label": "conclusions", "text": "FCMT improves social interactions in the home and community and the parent-child relationship , but not language skills or general social responsiveness .", "sentence_id": 8}
+{"abstract_id": "24261547", "label": "conclusions", "text": "This study provides preliminary support for the use of FCMT to promote social engagement in children with severe ASD .", "sentence_id": 9}
+{"abstract_id": "24794703", "label": "background", "text": "Insulin analogues have been developed to reduce the risk of hypoglycaemia in patients with diabetes who require insulin-based treatment , but their effect on this endpoint in patients with type @ diabetes complicated by recurrent severe hypoglycaemia is unknown .", "sentence_id": 0}
+{"abstract_id": "24794703", "label": "background", "text": "We compared the occurrence of severe hypoglycaemic episodes in such patients during treatment with insulin analogues or human insulin .", "sentence_id": 1}
+{"abstract_id": "24794703", "label": "methods", "text": "In this investigator-initiated , prospective , randomised , open-label , blinded-endpoint crossover trial at seven medical centres in Denmark , we recruited patients ( aged @ years ) with type @ diabetes ( diagnosed for > @ years ) who had reported two or more episodes of severe hypoglycaemia in the preceding year .", "sentence_id": 2}
+{"abstract_id": "24794703", "label": "methods", "text": "Patients were randomly assigned ( @:@ ) using computer-generated site-specific randomisation lists in blocks of four to treatment with basal-bolus therapy with either analogue insulin ( detemir and aspart ) or human insulin ( human neutral protamine Hagedorn and human regular ) in a balanced crossover design .", "sentence_id": 3}
+{"abstract_id": "24794703", "label": "methods", "text": "A @-year plus @-year treatment period was specified , consisting of two @-month run-in periods , each followed by a @-month maintenance period .", "sentence_id": 4}
+{"abstract_id": "24794703", "label": "methods", "text": "The primary endpoint was the number of validated episodes of severe hypoglycaemia ( defined by need for treatment assistance from others ) reported during the maintenance periods , analysed by intention to treat .", "sentence_id": 5}
+{"abstract_id": "24794703", "label": "methods", "text": "The study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 6}
+{"abstract_id": "24794703", "label": "results", "text": "Between May @ , @ , and Oct @ , @ , @ patients were randomly assigned .", "sentence_id": 7}
+{"abstract_id": "24794703", "label": "results", "text": "@ patients discontinued during the first run-in period , leaving @ patients in the intention-to-treat population .", "sentence_id": 8}
+{"abstract_id": "24794703", "label": "results", "text": "@ severe hypoglycaemic episodes were reported during treatment with human insulin and @ episodes were reported during treatment with insulin analogues , resulting in an absolute rate reduction of @ episodes ( @ % CI @-@ @ ) per patient-year with insulin analogues .", "sentence_id": 9}
+{"abstract_id": "24794703", "label": "results", "text": "This result corresponds to a relative rate reduction of @ % ( @ % CI @-@ ; p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24794703", "label": "conclusions", "text": "Treatment with insulin detemir and aspart in patients with type @ diabetes and recurrent severe hypoglycaemia resulted in a clinically significant reduced rate of severe hypoglycaemia compared with human insulin .", "sentence_id": 11}
+{"abstract_id": "24794703", "label": "conclusions", "text": "Patients with the greatest chance of benefitting from improved insulin therapy should be offered treatment with insulin analogues and be included in future trials of new insulins .", "sentence_id": 12}
+{"abstract_id": "24814320", "label": "objective", "text": "To evaluate the effects of humor therapy assessed using observational methods on agitation , engagement , positive behaviors , affect , and contentment .", "sentence_id": 0}
+{"abstract_id": "24814320", "label": "methods", "text": "Single-blind cluster randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24814320", "label": "methods", "text": "A total of @ Sydney nursing homes .", "sentence_id": 2}
+{"abstract_id": "24814320", "label": "methods", "text": "All eligible residents within geographically defined areas within each nursing home were invited to participate .", "sentence_id": 3}
+{"abstract_id": "24814320", "label": "methods", "text": "Professional `` ElderClowns '' provided @ to @ weekly humor therapy sessions , augmented by resident engagement by trained staff `` LaughterBosses . ''", "sentence_id": 4}
+{"abstract_id": "24814320", "label": "methods", "text": "Controls received usual care .", "sentence_id": 5}
+{"abstract_id": "24814320", "label": "methods", "text": "The Behavior Engagement Affect Measure ( BEAM ) touchpad observational tool was used to capture real-time behavioral data .", "sentence_id": 6}
+{"abstract_id": "24814320", "label": "methods", "text": "The tool assesses the duration in seconds of agitation , positive behavior toward others , engagement , and affect ( angry , anxious , happy , neutral , sad ) .", "sentence_id": 7}
+{"abstract_id": "24814320", "label": "results", "text": "Seventeen nursing homes ( @ residents ) received the intervention and @ homes ( @ residents ) received usual care .", "sentence_id": 8}
+{"abstract_id": "24814320", "label": "results", "text": "Over @ weeks , in comparison with controls , the humor therapy group decreased in duration of high agitation ( effect size = @ and @ at @ and @ weeks , respectively ) and increased in duration of happiness ( effect size = @ and @ at @ and @ weeks , respectively ) .", "sentence_id": 9}
+{"abstract_id": "24814320", "label": "conclusions", "text": "We confirmed that humor therapy decreases agitation and also showed that it increases happiness .", "sentence_id": 10}
+{"abstract_id": "24814320", "label": "conclusions", "text": "Researchers may consider evaluating impacts of nonpharmaceutical interventions on positive outcomes .", "sentence_id": 11}
+{"abstract_id": "24814320", "label": "conclusions", "text": "Computer-assisted observational measures should be considered , particularly for residents with dementia and when the reliability of staff is uncertain .", "sentence_id": 12}
+{"abstract_id": "25159818", "label": "objective", "text": "To investigate whether a histone deacetylase inhibitor ( HDACi ) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia ( FRDA ) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients .", "sentence_id": 0}
+{"abstract_id": "25159818", "label": "methods", "text": "We used a human FRDA neuronal cell model , derived from patient induced pluripotent stem cells , to determine the efficacy of a @-aminobenzamide HDACi ( @ ) as a modulator of FXN gene expression and chromatin histone modifications .", "sentence_id": 1}
+{"abstract_id": "25159818", "label": "methods", "text": "FRDA patients were dosed in @ cohorts , ranging from @mg/day to @mg/day of the formulated drug product of HDACi @ , RG@ .", "sentence_id": 2}
+{"abstract_id": "25159818", "label": "methods", "text": "Patients were monitored for adverse effects as well as for increases in FXN mRNA , frataxin protein , and chromatin modification in blood cells .", "sentence_id": 3}
+{"abstract_id": "25159818", "label": "results", "text": "In the neuronal cell model , HDACi @/RG@ increases FXN mRNA levels and frataxin protein , with concomitant changes in the epigenetic state of the gene .", "sentence_id": 4}
+{"abstract_id": "25159818", "label": "results", "text": "Chromatin signatures indicate that histone H@ lysine @ is a key residue for gene silencing through methylation and reactivation through acetylation , mediated by the HDACi .", "sentence_id": 5}
+{"abstract_id": "25159818", "label": "results", "text": "Drug treatment in FRDA patients demonstrated increased FXN mRNA and H@ lysine @ acetylation in peripheral blood mononuclear cells .", "sentence_id": 6}
+{"abstract_id": "25159818", "label": "results", "text": "No safety issues were encountered .", "sentence_id": 7}
+{"abstract_id": "25159818", "label": "conclusions", "text": "Drug exposure inducing epigenetic changes in neurons in vitro is comparable to the exposure required in patients to see epigenetic changes in circulating lymphoid cells and increases in gene expression .", "sentence_id": 8}
+{"abstract_id": "25159818", "label": "conclusions", "text": "These findings provide a proof of concept for the development of an epigenetic therapy for this fatal neurological disease .", "sentence_id": 9}
+{"abstract_id": "26054177", "label": "objective", "text": "To evaluate the effectiveness and tolerability of an experimental @ % hydrogen peroxide whitening strip relative to a placebo control over a three-week period .", "sentence_id": 0}
+{"abstract_id": "26054177", "label": "methods", "text": "In this parallel-design , double-blind clinical trial , @ adult volunteers were randomized to an experimental @ % hydrogen peroxide whitening strip or placebo strip balancing for age and baseline tooth color , and received treatment .", "sentence_id": 1}
+{"abstract_id": "26054177", "label": "methods", "text": "Strips were worn on the maxillary arch @ minutes daily for @ days .", "sentence_id": 2}
+{"abstract_id": "26054177", "label": "methods", "text": "Efficacy was measured objectively as L * a * b * color change from digital images at Days @ , @ , @ , and @ .", "sentence_id": 3}
+{"abstract_id": "26054177", "label": "results", "text": "As early as Day @ and at all subsequent visits , the @ % strip group experienced significant ( p < @ ) color improvement relative to placebo for b * and L * color parameters .", "sentence_id": 4}
+{"abstract_id": "26054177", "label": "results", "text": "The amount of color improvement increased with continuing peroxide strip use .", "sentence_id": 5}
+{"abstract_id": "26054177", "label": "results", "text": "Mean SE between-group differences in Ab * were -@ @ , -@ @ , -@ @ , and -@ @ at Days @ , @ , @ , and @ , respectively .", "sentence_id": 6}
+{"abstract_id": "26054177", "label": "results", "text": "Similar results were noted for AL * .", "sentence_id": 7}
+{"abstract_id": "26054177", "label": "results", "text": "Minor tooth sensitivity was the most common adverse event , as reported by @ % of subjects in the @ % strip group and @ % of subjects in the placebo group .", "sentence_id": 8}
+{"abstract_id": "26054177", "label": "results", "text": "No subjects discontinued treatment due to an adverse event .", "sentence_id": 9}
+{"abstract_id": "26054177", "label": "conclusions", "text": "This placebo-controlled clinical trial demonstrated that an experimental @ % hydrogen peroxide strip yielded significant tooth whitening relative to a placebo strip as early as after three days of product use .", "sentence_id": 10}
+{"abstract_id": "24750973", "label": "background", "text": "Although previous studies have found reminder/recall to be effective in increasing immunization rates , little guidance exists regarding the specific ages at which it is optimal to send reminder/recall notices .", "sentence_id": 0}
+{"abstract_id": "24750973", "label": "objective", "text": "To assess the relative effectiveness of centralized reminder/recall strategies targeting age-specific vaccination milestones among children in urban areas during June @-June @ .", "sentence_id": 1}
+{"abstract_id": "24750973", "label": "methods", "text": "Three reminder/recall strategies used capabilities of the Michigan Care Improvement Registry ( MCIR ) , a statewide immunization information system : a @-month recall strategy , a @-month reminder strategy , and a @-month recall strategy .", "sentence_id": 2}
+{"abstract_id": "24750973", "label": "methods", "text": "Eligible children were randomized to notification ( intervention ) or no notification groups ( control ) .", "sentence_id": 3}
+{"abstract_id": "24750973", "label": "methods", "text": "Primary study outcomes included MCIR-recorded immunization activity ( administration of @ new dose , entry of @ historic dose , entry of immunization waiver ) within @ days following each notification cycle .", "sentence_id": 4}
+{"abstract_id": "24750973", "label": "results", "text": "A total of @,@ children were included : @,@ for the @-month recall , @,@ for the @-month reminder , and @,@ for the @-month recall .", "sentence_id": 5}
+{"abstract_id": "24750973", "label": "results", "text": "Immunization activity was similar between notification versus no notification groups at both @ and @ months .", "sentence_id": 6}
+{"abstract_id": "24750973", "label": "results", "text": "Significantly more @-month-old children in the recall group ( @ % ) had immunization activity compared to their counterparts who did not receive a recall notification ( @ % ) .", "sentence_id": 7}
+{"abstract_id": "24750973", "label": "conclusions", "text": "Although recall notifications can positively affect immunization activity , the effect may vary by targeted age group .", "sentence_id": 8}
+{"abstract_id": "24750973", "label": "conclusions", "text": "Many @ - and @-month-olds had immunization activity following reminder/recall ; however , levels of activity were similar irrespective of notification , suggesting that these groups were likely to receive medical care or immunization services without prompting .", "sentence_id": 9}
+{"abstract_id": "25038861", "label": "objective", "text": "To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis .", "sentence_id": 0}
+{"abstract_id": "25038861", "label": "methods", "text": "Seventy-five patients and @ healthy volunteers were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "25038861", "label": "methods", "text": "Renal function and kidney biopsies were evaluated .", "sentence_id": 2}
+{"abstract_id": "25038861", "label": "methods", "text": "For DTI , a respiratory-triggered coronal EPI sequence was performed ( TR , @ ms ; TE , @ ms ; diffusion direction , @ ; NEX , @ ; b values , @ and @ s/mm@ ; slices thickness , @ mm , with no intersection gap ) .", "sentence_id": 3}
+{"abstract_id": "25038861", "label": "methods", "text": "Renal ADC and FA values were calculated and compared between the groups .", "sentence_id": 4}
+{"abstract_id": "25038861", "label": "methods", "text": "Correlations between ADC/FA and histopathology were evaluated .", "sentence_id": 5}
+{"abstract_id": "25038861", "label": "results", "text": "ADC values decreased with increased stages .", "sentence_id": 6}
+{"abstract_id": "25038861", "label": "results", "text": "ADC differences in renal parenchyma at different disease stages were found , with the exception of the control group compared with stage @ patients ; similar results were obtained for FA .", "sentence_id": 7}
+{"abstract_id": "25038861", "label": "results", "text": "ADC values in the cortex and medulla in stage @-@ patients were both statistically different , similar to the FA values .", "sentence_id": 8}
+{"abstract_id": "25038861", "label": "results", "text": "A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex ( r = -@ ) , similar to the degree of tubulointerstitial fibrosis with FA in the medulla ( r = -@ ) .", "sentence_id": 9}
+{"abstract_id": "25038861", "label": "conclusions", "text": "ADC and FA values are correlated with the degree of renal impairment , the percentage of glomerulosclerosis , and area of interstitial fibrosis .", "sentence_id": 10}
+{"abstract_id": "25038861", "label": "conclusions", "text": "DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis .", "sentence_id": 11}
+{"abstract_id": "25038861", "label": "conclusions", "text": "ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis .", "sentence_id": 12}
+{"abstract_id": "25038861", "label": "conclusions", "text": "Identification of renal impairment is helpful for timely treatment .", "sentence_id": 13}
+{"abstract_id": "25038861", "label": "conclusions", "text": "DTI can be used for non-invasive assessment of renal pathology .", "sentence_id": 14}
+{"abstract_id": "25327949", "label": "background", "text": "Posttraumatic stress disorder ( PTSD ) is associated with abnormal functioning of the hypothalamic-pituitary-adrenal ( HPA ) axis ; however , limited research has examined whether cortisol levels change following successful PTSD treatment .", "sentence_id": 0}
+{"abstract_id": "25327949", "label": "background", "text": "The current study examined the impact of successful PTSD treatment on the cortisol awakening response ( CAR ) .", "sentence_id": 1}
+{"abstract_id": "25327949", "label": "methods", "text": "Twenty-nine adults participating in a treatment trial for chronic PTSD provided saliva samples ( upon waking , and @ - , @ - , and @ min postwaking ) before and after receiving either prolonged exposure therapy or sertraline .", "sentence_id": 2}
+{"abstract_id": "25327949", "label": "methods", "text": "PTSD responder status ( i.e. , loss or retention of a PTSD diagnosis ) served as the predictor variable .", "sentence_id": 3}
+{"abstract_id": "25327949", "label": "methods", "text": "Outcome measures included area under the curve with respect to ground and increase , reflecting total cortisol output and HPA axis reactivity , respectively .", "sentence_id": 4}
+{"abstract_id": "25327949", "label": "results", "text": "A series of hierarchical regressions revealed no significant main effects of PTSD responder status for either CAR outcome .", "sentence_id": 5}
+{"abstract_id": "25327949", "label": "results", "text": "However , a significant gender by treatment response interaction for cortisol reactivity revealed that female treatment nonresponders displayed higher cortisol reactivity following treatment than female responders , whereas cortisol reactivity did not change pre - to posttreatment for male responders .", "sentence_id": 6}
+{"abstract_id": "25327949", "label": "results", "text": "Findings remained after controlling for age , trauma history , baseline medication status , baseline PTSD , and baseline depressive symptoms .", "sentence_id": 7}
+{"abstract_id": "25327949", "label": "conclusions", "text": "Loss of a PTSD diagnosis may contribute to decreased cortisol reactivity in females .", "sentence_id": 8}
+{"abstract_id": "25327949", "label": "conclusions", "text": "Neuroendocrine changes following treatment may emerge only for specific subgroups , highlighting the importance of exploring treatment moderators .", "sentence_id": 9}
+{"abstract_id": "25644221", "label": "background", "text": "Abundant evidence suggests that allelic variation in the serotonin transporter-linked polymorphic region ( @-HTTLPR ) influences susceptibility to stress and its affective consequences due to brain serotonergic vulnerability .", "sentence_id": 0}
+{"abstract_id": "25644221", "label": "background", "text": "Based on recent assumptions , the present study examined whether the @-HTTLPR genotype may also interact with a vulnerability to chronic stress experience ( conceptualized by trait neuroticism ) in order to influence sleep quality and , additionally , whether this is influenced by brain serotonergic manipulations .", "sentence_id": 1}
+{"abstract_id": "25644221", "label": "methods", "text": "In a well-balanced experimental design , homozygous S-allele ( n = @ ) and L-allele ( n = @ ) genotypes with high and low chronic stress vulnerability ( neuroticism ) were first assessed for general past sleep quality during a month before onset of the experiment .", "sentence_id": 2}
+{"abstract_id": "25644221", "label": "methods", "text": "Then subjects were assessed for sleep quality following @ days of tryptophan ( @ g/day ) or placebo intake .", "sentence_id": 3}
+{"abstract_id": "25644221", "label": "results", "text": "Although high neuroticism was significantly related to a higher frequency of stressful life events and daily hassles , it did not interact with the @-HTTLPR genotype on general past sleep quality .", "sentence_id": 4}
+{"abstract_id": "25644221", "label": "results", "text": "However , as expected , a @ day period of tryptophan administration was exclusively associated with better sleep quality scores in the S ' / S ' genotype with high trait neuroticism .", "sentence_id": 5}
+{"abstract_id": "25644221", "label": "conclusions", "text": "Current findings suggest that @-HTTLPR does not directly interact with stress vulnerability in order to influence sleep quality .", "sentence_id": 6}
+{"abstract_id": "25644221", "label": "conclusions", "text": "Instead , based on current and previous findings , it is suggested that the S ' / S ' @-HTTLPR genotype promotes the risk for stress-related sleep disturbances because of an increased susceptibility to the depressogenic consequences of stress .", "sentence_id": 7}
+{"abstract_id": "25644221", "label": "conclusions", "text": "Accordingly , by way of reducing depressive symptomatology , tryptophan augmentation may particularly improve sleep quality in stress-vulnerable individuals carrying the @-HTTLPR S-allele .", "sentence_id": 8}
+{"abstract_id": "25911762", "label": "objective", "text": "By using orthogonal design method to optimnize prescription of pulsed electric field at Jiaji ( EX - B @ ) points for spinal cord injury ( SCI ) .", "sentence_id": 0}
+{"abstract_id": "25911762", "label": "methods", "text": "Fifty six patients of SCI were selected , in which @ cases were divided into orthogonal design trial and @ cases were into clinical verification .", "sentence_id": 1}
+{"abstract_id": "25911762", "label": "methods", "text": "With @ patients who received orthogonal design trial , Frankel grading scale was used as observation index to screen optimal prescription of pulsed electric field .", "sentence_id": 2}
+{"abstract_id": "25911762", "label": "methods", "text": "Pulse frequency ( factor A ) included low frequency ( factor A ( I ) , @ ( @ ) Hz ) .", "sentence_id": 3}
+{"abstract_id": "25911762", "label": "methods", "text": "moderate frequency ( factor A ( II ) , @ ( @ ) Hz ) and high frequency ( factor A ( III ) , @ ( @ ) Hz ) ; pulse amplitude ( factor B ) included @-@ V ( factor B ) , @-@ V ( factor B ( II ) ) and @-@ V ( factor B ( III ) ) ; pulse width ( factor C ) included @ ms ( factor C ( I ) ) .", "sentence_id": 4}
+{"abstract_id": "25911762", "label": "methods", "text": "@ ms ( factor C ( II ) ) and @ ms ( factor C ( III ) ) ; acupuncture time ( factor D ) included one month ( DI ) , three months ( D ( II ) ) and five months ( D ( III ) ) .", "sentence_id": 5}
+{"abstract_id": "25911762", "label": "methods", "text": "Twenty patients were used for clinical efficacy observation and the effects of screened optimal pre scription of pulsed electric field at Jiaji ( EX-B @ ) points combined with regular rehabilitation training on spasm se - verity , score of sensory and motor functions , Barthel index and Frankel score were observed .", "sentence_id": 6}
+{"abstract_id": "25911762", "label": "results", "text": "( @ ) As results of orthogonal design trial , the optimal prescription was A ( III ) B ( III ) , C ( I ) , D ( III ) , which were high frequency ( @ ( @ ) Hz ) , @-@ V of pulse amplitude , @ ms of pulse width and @ months of treatment time .", "sentence_id": 7}
+{"abstract_id": "25911762", "label": "results", "text": "( @ ) As results of @ patient clinical verification , Ashworth score , tendon reflex and clonus were all significantly improved ( P < @ , P < @ ) , the scores of sensory and motor functions were evidently improvedtl ( P < @ , P < @ ) , and Barthel in dex and Frankel score were also enhanced ( P < @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25911762", "label": "conclusions", "text": "The optimal prescription of pulsed electric field at Jiaji ( EX-B @ ) points for spinal cord injury is high frequency ( @ & Hz ) , @-@ V of pulse amplitude , @ ms of pulse width and @ months of treatment time .", "sentence_id": 9}
+{"abstract_id": "25911762", "label": "conclusions", "text": "The optimal prescription of pulsed electric field at Jiaji ( EX-B @ ) points combined with regular rehabilitation could obviously improve spasm severity , enhance senso - ry and motor functions , and ameliorate activity of daily life and Frankel score .", "sentence_id": 10}
+{"abstract_id": "26427109", "label": "objective", "text": "To compare the impacts of electroacu puncture ( EA ) and moxibustion ( Mox ) on the prima ry gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P ( SP ) and vasoactive intestinal peptide ( VIP ) in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome ( IBS-D and IBS-C , respectively ) .", "sentence_id": 0}
+{"abstract_id": "26427109", "label": "methods", "text": "Eighty-five IBS patients were randomly allocated to the EA and Mox groups .", "sentence_id": 1}
+{"abstract_id": "26427109", "label": "methods", "text": "Zusanli ( ST @ ) and Shangjuxu ( ST @ ) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for @ consecutive days .", "sentence_id": 2}
+{"abstract_id": "26427109", "label": "methods", "text": "Before and after the treatment sessions , a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms .", "sentence_id": 3}
+{"abstract_id": "26427109", "label": "methods", "text": "There were four dropout cases , leaving @ participants ( @ with IBS-D and @ with IBS-C ) who volunteered to undergo colonoscopy before and after the treatment sessions .", "sentence_id": 4}
+{"abstract_id": "26427109", "label": "methods", "text": "During colonoscopy , sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay .", "sentence_id": 5}
+{"abstract_id": "26427109", "label": "results", "text": "Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients .", "sentence_id": 6}
+{"abstract_id": "26427109", "label": "results", "text": "However , Mox was more effective at reducing diarrhea in IBS-D patients , whereas EA was more effective at improving constipation in IBS-C patients .", "sentence_id": 7}
+{"abstract_id": "26427109", "label": "results", "text": "EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa , with no significant difference shown between the two treatments .", "sentence_id": 8}
+{"abstract_id": "26427109", "label": "conclusions", "text": "Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients .", "sentence_id": 9}
+{"abstract_id": "24939678", "label": "objective", "text": "The aim of this study was to assess the usefulness of colour duplex sonography ( CDS ) - guided temporal artery biopsy ( TAB ) for the diagnosis of GCA in patients with suspected GCA .", "sentence_id": 0}
+{"abstract_id": "24939678", "label": "methods", "text": "From September @ through December @ , @ consecutive patients with suspected GCA were randomized to undergo CDS-guided TAB or standard TAB .", "sentence_id": 1}
+{"abstract_id": "24939678", "label": "methods", "text": "All patients underwent temporal artery physical examination and temporal artery CDS prior to TAB .", "sentence_id": 2}
+{"abstract_id": "24939678", "label": "methods", "text": "CDS of the temporal artery was performed by the same ultrasonographer , who was unaware of the patient 's clinical data , and all TABs were evaluated by the same pathologist .", "sentence_id": 3}
+{"abstract_id": "24939678", "label": "methods", "text": "Seven patients in whom biopsy failed to sample temporal artery tissue were excluded from the analysis .", "sentence_id": 4}
+{"abstract_id": "24939678", "label": "results", "text": "Fifty patients were randomized to undergo CDS-guided TAB and @ patients to standard TAB .", "sentence_id": 5}
+{"abstract_id": "24939678", "label": "results", "text": "Except for a younger age in patients who underwent standard TAB ( P = @ ) , no significant differences were observed between the two groups .", "sentence_id": 6}
+{"abstract_id": "24939678", "label": "results", "text": "There were no significant differences in the frequencies of positive TAB for classic transmural inflammation ( @ % vs @ % ) or for periadventitial small vessel vasculitis and/or vasa vasorum vasculitis ( @ % vs @ % ) between the two groups .", "sentence_id": 7}
+{"abstract_id": "24939678", "label": "results", "text": "No significant differences in the frequency of positive TAB in the two groups were observed when we excluded the patients treated with glucocorticoids and when we stratified the patients of the two groups for the presence or absence of the halo sign .", "sentence_id": 8}
+{"abstract_id": "24939678", "label": "conclusions", "text": "Our study showed that CDS-guided TAB did not improve the sensitivity of TAB for diagnosing GCA .", "sentence_id": 9}
+{"abstract_id": "24815298", "label": "background", "text": "The importance of interactions between the host and gut microbiota in the pathogenesis of irritable bowel syndrome ( IBS ) is becoming increasingly apparent .", "sentence_id": 0}
+{"abstract_id": "24815298", "label": "background", "text": "Probiotics offer a potential new treatment for IBS , but current results are conflicting , largely as a result of poorly designed trials and nonstandardisation of outcome measures .", "sentence_id": 1}
+{"abstract_id": "24815298", "label": "objective", "text": "To assess the efficacy of a liquid , multi-strain probiotic ( Symprove ) in IBS .", "sentence_id": 2}
+{"abstract_id": "24815298", "label": "methods", "text": "A single-centre , randomised , double-blind , placebo-controlled trial of adult patients with symptomatic IBS .", "sentence_id": 3}
+{"abstract_id": "24815298", "label": "methods", "text": "Patients received @ weeks of treatment with the probiotic or placebo ( @ mL/kg/day ) .", "sentence_id": 4}
+{"abstract_id": "24815298", "label": "methods", "text": "The primary efficacy measure was the difference in change in the IBS symptom severity score ( IBS-SSS ) between probiotic vs. placebo at week @ .", "sentence_id": 5}
+{"abstract_id": "24815298", "label": "methods", "text": "Secondary outcome measures included change in the IBS quality of life ( IBS-QOL ) score and change in the IBS-SSS symptom component scores .", "sentence_id": 6}
+{"abstract_id": "24815298", "label": "results", "text": "A total of @ patients were randomised and @ patients completed the study .", "sentence_id": 7}
+{"abstract_id": "24815298", "label": "results", "text": "The mean change in IBS-SSS was -@ probiotic vs. -@ placebo .", "sentence_id": 8}
+{"abstract_id": "24815298", "label": "results", "text": "The mean difference in the IBS-SSS was statistically significant -LSB- -@ ( @ % CI ; -@ , -@ ) ; P = @ -RSB- .", "sentence_id": 9}
+{"abstract_id": "24815298", "label": "results", "text": "There was no significant improvement in the IBS-QOL .", "sentence_id": 10}
+{"abstract_id": "24815298", "label": "results", "text": "No serious adverse events were reported .", "sentence_id": 11}
+{"abstract_id": "24815298", "label": "conclusions", "text": "The multi-strain probiotic was associated with a statistically significant improvement in overall symptom severity in patients with IBS , and was well tolerated .", "sentence_id": 12}
+{"abstract_id": "24815298", "label": "conclusions", "text": "These results suggest this probiotic confers benefit in IBS and deserves further investigation ( ISRCTN identifier : @ ) .", "sentence_id": 13}
+{"abstract_id": "24740826", "label": "objective", "text": "Bevacizumab , a humanized monoclonal antibody against vascular endothelial growth factor , has shown increased pathological complete response rates when added to neoadjuvant chemotherapy .", "sentence_id": 0}
+{"abstract_id": "24740826", "label": "objective", "text": "In various cancer types , bevacizumab treatment was accompanied by an increased risk of bleedings and other surgical complications .", "sentence_id": 1}
+{"abstract_id": "24740826", "label": "objective", "text": "We assessed associated surgical complications .", "sentence_id": 2}
+{"abstract_id": "24740826", "label": "methods", "text": "In the GeparQuinto trial , @,@ patients were randomized to receive four cycles epirubicin/cyclophosphamide ( EC , @/@mg/m ( @ ) q@w ) followed by four cycles docetaxel ( D , @mg/m ( @ ) q@w ) each with ( ECB-DB ) or without ( EC-D ) bevacizumab ( B , @mg/kg q@w ) concurrent with chemotherapy .", "sentence_id": 3}
+{"abstract_id": "24740826", "label": "methods", "text": "Surgery had to be performed not earlier than @days after the last bevacizumab infusion , but within days @ and @ after the last chemotherapy .", "sentence_id": 4}
+{"abstract_id": "24740826", "label": "results", "text": "In @ ( @ % ) patients , a surgical complication ( bleedings , hematomas , necrosis , wound infections , abscess ) was documented prospectively .", "sentence_id": 5}
+{"abstract_id": "24740826", "label": "results", "text": "Baseline characteristics of the patients were well balanced between both arms .", "sentence_id": 6}
+{"abstract_id": "24740826", "label": "results", "text": "The breast-conserving surgery ( BCS ) rate ( N = @ ) was @ % ( EC-D ) and @ % ( ECB-DB ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24740826", "label": "results", "text": "The first surgical procedure was performed at a median of @ ( EC-D ) and @days ( ECB-DB ) after last chemotherapy with or without bevacizumab infusion ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24740826", "label": "results", "text": "Surgical complications were documented in @ ( @ % ; EC-D ) and @ ( @ % ; ECB-DB ) patients ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24740826", "label": "results", "text": "Surgical complications were significantly higher after ECD-DB only in patients treated with BCS ( N = @ ; p = @ ) or in those requiring repeat surgery in order achieve clear margins ( N = @ ; p = @ ) compared to the EC-D group .", "sentence_id": 10}
+{"abstract_id": "24740826", "label": "conclusions", "text": "Addition of bevacizumab to neoadjuvant chemotherapy might be associated with an increased risk for surgical complications in patients treated with BCS or after repeated surgeries .", "sentence_id": 11}
+{"abstract_id": "24557989", "label": "background", "text": "Whether convective therapies allow better control of serum phosphate ( P ) is still undefined , and no data are available concerning on-line haemofiltration ( HF ) .", "sentence_id": 0}
+{"abstract_id": "24557989", "label": "background", "text": "The objectives of the study are to evaluate the effect of convective treatments ( CTs ) on P levels in comparison with low-flux haemodialysis ( HD ) and to evaluate the correlates of serum phosphate in a post hoc analysis of a randomized clinical trial .", "sentence_id": 1}
+{"abstract_id": "24557989", "label": "methods", "text": "This analysis was performed in the database of a multicentre , open label and randomized controlled study in which @ chronic HD patients from @ Italian centres were randomly assigned to HD ( @ patients ) or CTs : on-line pre-dilution HF ( @ patients ) or on-line pre-dilution haemodiafiltration ( @ patients ) .", "sentence_id": 2}
+{"abstract_id": "24557989", "label": "results", "text": "CTs did not affect P ( P = @ ) , calcium ( Ca ) ( P = @ ) and parathyroid hormone levels ( P = @ ) .", "sentence_id": 3}
+{"abstract_id": "24557989", "label": "results", "text": "P levels were associated with the use of phosphate binders including aluminium-based phosphate binders ( P < @ ) and sevelamer ( P < @ ) , pre-dialysis bicarbonate levels ( P < @ ) and pre-dialysis blood K levels ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24557989", "label": "results", "text": "On multivariate analysis ( generalized linear model ) , serum P was again largely unassociated with CTs ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24557989", "label": "results", "text": "Notably , participating centres were by far the strongest independent correlate of serum P , explaining @ % of the variance of serum P over the trial and this association was confirmed at multivariate analysis .", "sentence_id": 6}
+{"abstract_id": "24557989", "label": "results", "text": "Bicarbonate ( P < @ ) and , to a weaker extent , serum K ( P = @ ) were independently related to serum P.", "sentence_id": 7}
+{"abstract_id": "24557989", "label": "conclusions", "text": "In comparison with low-flux HD , CTs did not significantly affect serum P levels .", "sentence_id": 8}
+{"abstract_id": "24557989", "label": "conclusions", "text": "Participating centres were the main source of P variability during the trial followed by treatment with phosphate binders , serum bicarbonate and , to a weak extent , serum potassium levels ( ClinicalTrials.gov Identifier : NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "24618231", "label": "background", "text": "Fine particulate matter ( PM ) air pollution is associated with numerous adverse health effects , including increased blood pressure ( BP ) and vascular dysfunction .", "sentence_id": 0}
+{"abstract_id": "24618231", "label": "background", "text": "Coarse PM substantially contributes to global air pollution , yet differs in characteristics from fine particles and is currently not regulated .", "sentence_id": 1}
+{"abstract_id": "24618231", "label": "background", "text": "However , the cardiovascular ( CV ) impacts of coarse PM exposure remain largely unknown .", "sentence_id": 2}
+{"abstract_id": "24618231", "label": "objective", "text": "Our goal was to elucidate whether coarse PM , like fine PM , is itself capable of eliciting adverse CV responses .", "sentence_id": 3}
+{"abstract_id": "24618231", "label": "methods", "text": "We performed a randomized double-blind crossover study in which @ healthy adults ( @ @ years of age ) were exposed to concentrated ambient coarse particles ( CAP ; @ @ g/m ( @ ) ) in a rural location and filtered air ( FA ) for @ hr .", "sentence_id": 4}
+{"abstract_id": "24618231", "label": "methods", "text": "We measured CV outcomes during , immediately after , and @ hr postexposures .", "sentence_id": 5}
+{"abstract_id": "24618231", "label": "results", "text": "Both systolic ( mean difference = @ mmHg ; @ % CI : @ , @ ; p = @ ) and diastolic BP ( @ mmHg ; @ % CI : @ , @ ; p = @ ) linearly increased per @ min of exposure during the inhalation of coarse CAP when compared with changes during FA exposure .", "sentence_id": 6}
+{"abstract_id": "24618231", "label": "results", "text": "Heart rate was on average higher ( @ bpm ; @ % CI : @ , @ ; p < @ ) and the ratio of low-to-high frequency heart rate variability increased ( @ ; @ % CI : @ , @ ; p = @ ) during coarse particle versus FA exposure .", "sentence_id": 7}
+{"abstract_id": "24618231", "label": "results", "text": "Other outcomes ( brachial flow-mediated dilatation , microvascular reactive hyperemia index , aortic hemodynamics , pulse wave velocity ) were not differentially altered by the exposures .", "sentence_id": 8}
+{"abstract_id": "24618231", "label": "conclusions", "text": "Inhalation of coarse PM from a rural location is associated with a rapid elevation in BP and heart rate during exposure , likely due to the triggering of autonomic imbalance .", "sentence_id": 9}
+{"abstract_id": "24618231", "label": "conclusions", "text": "These findings add mechanistic evidence supporting the biological plausibility that coarse particles could contribute to the triggering of acute CV events .", "sentence_id": 10}
+{"abstract_id": "24462484", "label": "objective", "text": "There have been repeated calls from health professionals and policy-makers to clarify the side-effects of the increasingly popular consumption trend of alcohol mixed with energy drinks ( AmED ) .", "sentence_id": 0}
+{"abstract_id": "24462484", "label": "objective", "text": "There is a dearth of research assessing the differential effects of AmED relative to alcohol by comparing self-reported psychological and physiological outcomes whilst under the influence of these substances .", "sentence_id": 1}
+{"abstract_id": "24462484", "label": "objective", "text": "The aim of the present study was to examine the acute effects of a moderate alcohol and energy drink ( ED ) dose on self-reported psychological and physiological outcomes .", "sentence_id": 2}
+{"abstract_id": "24462484", "label": "methods", "text": "Using a single-blind , placebo-controlled , crossover design , @ adults completed four sessions where they were administered : ( i ) @ g/kg alcohol , ( ii ) @ mL/kg ED , ( iii ) AmED , and ( iv ) placebo .", "sentence_id": 3}
+{"abstract_id": "24462484", "label": "methods", "text": "Participants independently completed the Profile of Mood States and a Somatic Symptom Scale at baseline and at @ and @min after beverage administration .", "sentence_id": 4}
+{"abstract_id": "24462484", "label": "results", "text": "Breath alcohol concentration peaked at @ % and @ % in the alcohol and AmED conditions , respectively .", "sentence_id": 5}
+{"abstract_id": "24462484", "label": "results", "text": "There were no interactive alcohol and ED effects on self-reported psychological outcomes .", "sentence_id": 6}
+{"abstract_id": "24462484", "label": "results", "text": "Treatment effects for physiological outcomes generally only related to alcohol or ED administration , with the exception of a moderate magnitude decrease in heart palpitation ratings following alcohol relative to AmED .", "sentence_id": 7}
+{"abstract_id": "24462484", "label": "results", "text": "Decreased muscular tension ratings were evident when the two constituents were consumed separately relative to placebo .", "sentence_id": 8}
+{"abstract_id": "24462484", "label": "conclusions", "text": "The results provide evidence of few subjective changes in physiological and psychological state after consuming AmED relative to alcohol .", "sentence_id": 9}
+{"abstract_id": "24462484", "label": "conclusions", "text": "The majority of treatment-based changes arose from the independent effects of alcohol or ED , rather than being modified by their interaction .", "sentence_id": 10}
+{"abstract_id": "24462484", "label": "conclusions", "text": "However , research extending into higher dosage domains is required to increase outcome generalisability for consumers in the night-time economy .", "sentence_id": 11}
+{"abstract_id": "25037462", "label": "objective", "text": "This randomized , controlled , single-blinded multicenter study evaluated the efficacy of latest-generation fibrin sealant containing synthetic aprotinin as fibrinolysis inhibitor as supportive treatment for hemostasis after elective partial hepatectomy .", "sentence_id": 0}
+{"abstract_id": "25037462", "label": "methods", "text": "Adult subjects undergoing resection of at least one liver segment were assigned to treatment with fibrin sealant or manual compression with a surgical gauze swab if persistent oozing necessitated additional hemostatic measures after primary control of arterial and venous bleeding .", "sentence_id": 1}
+{"abstract_id": "25037462", "label": "methods", "text": "The primary outcome measure was the proportion of subjects with intraoperative hemostasis at @ min after start of randomized treatment application .", "sentence_id": 2}
+{"abstract_id": "25037462", "label": "methods", "text": "Secondary efficacy outcome measures included intraoperative hemostasis at @ , @ , and @ min , intra - and postoperative rebleedings , transfusion requirements , and drainage volume .", "sentence_id": 3}
+{"abstract_id": "25037462", "label": "results", "text": "Seventy subjects were randomized .", "sentence_id": 4}
+{"abstract_id": "25037462", "label": "results", "text": "Hemostasis at @ min was achieved in @/@ ( @ % ) fibrin sealant subjects compared with @/@ ( @ % ) control subjects ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25037462", "label": "results", "text": "Significantly more fibrin sealant subjects achieved hemostasis at @ ( p < @ ) , @ ( p = @ ) , and @ min ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25037462", "label": "results", "text": "The number of rebleedings was low in both study arms .", "sentence_id": 7}
+{"abstract_id": "25037462", "label": "results", "text": "Transfusion requirements and @-h drainage volumes were similar between the study arms .", "sentence_id": 8}
+{"abstract_id": "25037462", "label": "results", "text": "No adverse events related to study treatment were reported .", "sentence_id": 9}
+{"abstract_id": "25037462", "label": "conclusions", "text": "Fibrin sealant was shown to be safe and superior to manual compression in the control of parenchymal bleeding after hepatic resection .", "sentence_id": 10}
+{"abstract_id": "25037462", "label": "conclusions", "text": "The use of synthetic aprotinin as fibrinolysis inhibitor further improves the safety margin of fibrin sealant by eliminating the risk of transmission of bovine spongiform encephalopathy and other bovine pathogens .", "sentence_id": 11}
+{"abstract_id": "24985779", "label": "background", "text": "Whether early antiretroviral therapy ( ART ) initiation could impact sexual risk behaviours remains to be documented .", "sentence_id": 0}
+{"abstract_id": "24985779", "label": "background", "text": "We aimed to investigate changes in sexual behaviours within the @ months following an early versus standard ART initiation in HIV-positive adults with high CD@ counts .", "sentence_id": 1}
+{"abstract_id": "24985779", "label": "methods", "text": "We used data from a prospective behavioural study nested in a randomized controlled trial of early ART ( Temprano-ANRS@ ) .", "sentence_id": 2}
+{"abstract_id": "24985779", "label": "methods", "text": "Time trends in sexual behaviours from enrolment in the trial ( M@ ) to @-month ( M@ ) and @-month ( M@ ) visits were measured and compared , using Generalized Estimating Equations models , between participants randomly assigned either to initiate ART immediately ( early ART ) or to defer ART initiation until on-going WHO starting criteria are met ( standard ART ) .", "sentence_id": 3}
+{"abstract_id": "24985779", "label": "methods", "text": "Indicators of sexual behaviours included @ ) sexual activity in the past year , @ ) multiple partnership in the past year , @ ) unprotected sex at last intercourse and @ ) risky sex ( i.e. unprotected sex with a partner of HIV negative/unknown status ) at last intercourse .", "sentence_id": 4}
+{"abstract_id": "24985779", "label": "results", "text": "Analyses included @ participants ( @ with early ART and @ with standard ART ; overall median baseline CD@ count : @/mm ( @ ) ) .", "sentence_id": 5}
+{"abstract_id": "24985779", "label": "results", "text": "Among participants with early ART , significant decreases were found between M@ and M@ in sexual activity ( Odds Ratio -LSB- OR -RSB- @ , @ % Confidence Interval -LSB- @ % CI -RSB- @-@ @ ) , multiple partnership ( OR @ , @ % CI @-@ @ ) , unprotected sex ( OR @ , @ % CI @-@ @ ) and risky sex ( OR @ , @ % CI @-@ @ ) .", "sentence_id": 6}
+{"abstract_id": "24985779", "label": "results", "text": "Among participants with standard ART , sexual behaviours showed similar trends over time .", "sentence_id": 7}
+{"abstract_id": "24985779", "label": "results", "text": "These decreases mostly occurred within the @ months following enrolment in the trial in both groups and prior to ART initiation in participants with standard ART .", "sentence_id": 8}
+{"abstract_id": "24985779", "label": "results", "text": "For unprotected sex and risky sex , decreases were or tended to be more pronounced among patients reporting that their last sexual partner was non-cohabiting .", "sentence_id": 9}
+{"abstract_id": "24985779", "label": "conclusions", "text": "In these sub-Saharan adults with high CD@ counts , entry into HIV care , rather than ART initiation , resulted in decreased sexual activity and risky sexual behaviours .", "sentence_id": 10}
+{"abstract_id": "24985779", "label": "conclusions", "text": "We did not observe any evidence of a risk compensation phenomenon associated with early ART initiation .", "sentence_id": 11}
+{"abstract_id": "24985779", "label": "conclusions", "text": "These results illustrate the potential behavioural preventive effect of early entry into care , which goes hand in hand with early ART initiation .", "sentence_id": 12}
+{"abstract_id": "24326980", "label": "background", "text": "Oropharyngeal dysphagia ( OD ) is a major gastrointestinal motility disorder that causes severe nutritional and respiratory complications in elderly and neurological patients .", "sentence_id": 0}
+{"abstract_id": "24326980", "label": "background", "text": "In an earlier study , we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential vanilloid @ ( TRPV@ ) improved the swallow response of dysphagic patients .", "sentence_id": 1}
+{"abstract_id": "24326980", "label": "background", "text": "The aim of this study was to explore the effect of piperine , a dual TRPV@/TRPA@ agonist , on the swallow response of dysphagic patients .", "sentence_id": 2}
+{"abstract_id": "24326980", "label": "methods", "text": "A videofluoroscopic study was performed to assess the signs of impaired safety and efficacy of swallow and the swallow response of @ dysphagic patients while swallowing one series of nectar control boluses and two series of nectar boluses supplemented with piperine .", "sentence_id": 3}
+{"abstract_id": "24326980", "label": "methods", "text": "Patients were randomized into two groups : one group received @ M piperine and the other group received @ mM .", "sentence_id": 4}
+{"abstract_id": "24326980", "label": "results", "text": "Piperine improved the safety of swallow by : ( a ) reducing the prevalence of unsafe swallows by -@ % ( P = @ ) at @ M and -@ % ( P < @ ) at @ mM , and the severity score of the penetration-aspiration scale from @ @ to @ @ ( P = @ , @ mM ) ; and ( b ) shortening the time to laryngeal vestibule closure from @ @ to @ @ s with @ M piperine ( P < @ ) and from @ @ to @ @ s with @ mM piperine ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24326980", "label": "conclusions", "text": "Supplementing the alimentary bolus with piperine speeds swallow response and strongly improves safety of swallow in patients with OD , with a maximal therapeutic effect at @ mM .", "sentence_id": 6}
+{"abstract_id": "24326980", "label": "conclusions", "text": "Our results suggest that activation of TRPV@/A@ in oropharyngeal sensory neurons is a very promising neurostimulation strategy for dysphagic patients .", "sentence_id": 7}
+{"abstract_id": "24316262", "label": "objective", "text": "We performed an open-label , multicenter , phase @ study of the safety and efficacy of twice-daily telaprevir in treatment-naive patients with chronic hepatitis C virus ( HCV ) genotype @ infection , including those with cirrhosis .", "sentence_id": 0}
+{"abstract_id": "24316262", "label": "methods", "text": "Patients were randomly assigned to groups treated with telaprevir @ mg twice daily or @ mg every @ hours plus peginterferon alfa-@a and ribavirin for @ weeks ; patients were then treated with peginterferon alfa-@a and ribavirin alone for @ weeks if their level of HCV RNA at week @ was < @ IU/mL or for @ weeks if their level was higher .", "sentence_id": 1}
+{"abstract_id": "24316262", "label": "methods", "text": "The primary objective was to demonstrate noninferiority of telaprevir twice daily versus every @ hours in producing a sustained virological response @ weeks after the end of therapy ( SVR@ ) ( based on a -@ % lower limit of the @ % lower confidence interval for the difference between groups ) .", "sentence_id": 2}
+{"abstract_id": "24316262", "label": "results", "text": "At baseline , of @ patients , @ % had levels of HCV RNA @,@ IU/mL , @ % had fibrosis ( F@-F@ ) , @ % had cirrhosis ( F@ ) , @ % were infected with HCV genotype @a , and @ % had the non-CC IL@B genotype .", "sentence_id": 3}
+{"abstract_id": "24316262", "label": "results", "text": "Of patients who were treated with telaprevir twice daily , @ % achieved SVR@ compared with @ % of patients who were treated with telaprevir every @ hours ( difference in response , @ % ; @ % confidence interval , -@ % to @ % ) , so telaprevir twice daily is noninferior to telaprevir every @ hours .", "sentence_id": 4}
+{"abstract_id": "24316262", "label": "results", "text": "All subgroups of patients who were treated with telaprevir twice daily versus those who were treated every @ hours had similar rates of SVR@ .", "sentence_id": 5}
+{"abstract_id": "24316262", "label": "results", "text": "The most frequent adverse events ( AEs ) in the telaprevir phase were fatigue ( @ % ) , pruritus ( @ % ) , anemia ( @ % ) , nausea ( @ % ) , rash ( @ % ) , and headache ( @ % ) ; serious AEs were reported in @ % of patients .", "sentence_id": 6}
+{"abstract_id": "24316262", "label": "results", "text": "Rates of AEs and serious AEs were similar or slightly higher among patients treated with telaprevir every @ hours .", "sentence_id": 7}
+{"abstract_id": "24316262", "label": "conclusions", "text": "Based on a phase @ trial , telaprevir twice daily is noninferior to every @ hours in producing SVR@ , with similar levels of safety and tolerability .", "sentence_id": 8}
+{"abstract_id": "24316262", "label": "conclusions", "text": "These results support use of telaprevir twice daily in patients with chronic HCV genotype @ infection , including those with cirrhosis .", "sentence_id": 9}
+{"abstract_id": "24316262", "label": "conclusions", "text": "ClinicalTrials.gov , Number : NCT@ .", "sentence_id": 10}
+{"abstract_id": "24885354", "label": "background", "text": "Radiotherapy has a good effect in palliation of painful bone metastases , with a pain response rate of more than @ % .", "sentence_id": 0}
+{"abstract_id": "24885354", "label": "background", "text": "However , shortly after treatment , in approximately @ % of patients a temporary pain flare occurs , which is defined as a two-point increase of the worst pain score on an @-point rating scale compared to baseline , without a decrease in analgesic intake , or a @ % increase in analgesic intake without a decrease in worst pain score , compared to baseline .", "sentence_id": 1}
+{"abstract_id": "24885354", "label": "background", "text": "A pain flare has a negative impact on daily functioning and mood of patients .", "sentence_id": 2}
+{"abstract_id": "24885354", "label": "background", "text": "It is thought to be caused by periostial edema after radiotherapy .", "sentence_id": 3}
+{"abstract_id": "24885354", "label": "background", "text": "Dexamethasone might diminish this edema and thereby reduce the incidence of pain flare .", "sentence_id": 4}
+{"abstract_id": "24885354", "label": "background", "text": "Two non-randomized studies suggest that dexamethasone reduces the incidence of a pain flare by @ % .", "sentence_id": 5}
+{"abstract_id": "24885354", "label": "background", "text": "The aim of this trial is to study the effectiveness of dexamethasone to prevent a pain flare after palliative radiotherapy for painful bone metastases and to determine the optimal dose schedule .", "sentence_id": 6}
+{"abstract_id": "24885354", "label": "methods", "text": "This study is a three-armed , double-blind , placebo-controlled multicenter trial .", "sentence_id": 7}
+{"abstract_id": "24885354", "label": "methods", "text": "We aim to include @ patients with uncomplicated painful bone metastases from any type of primary solid tumor who receive short schedule radiotherapy ( all conventional treatment schedules from one to six fractions ) .", "sentence_id": 8}
+{"abstract_id": "24885354", "label": "methods", "text": "Arm @ consists of daily placebo for four days , arm @ starts with @mg dexamethasone before the ( first ) radiotherapy and three days placebo thereafter .", "sentence_id": 9}
+{"abstract_id": "24885354", "label": "methods", "text": "Arm @ consists of four days @mg dexamethasone .", "sentence_id": 10}
+{"abstract_id": "24885354", "label": "methods", "text": "The primary endpoint is the occurrence of a pain flare .", "sentence_id": 11}
+{"abstract_id": "24885354", "label": "methods", "text": "Secondary endpoints are pain , quality of life and side-effects of dexamethasone versus placebo .", "sentence_id": 12}
+{"abstract_id": "24885354", "label": "methods", "text": "Patients complete a questionnaire ( Brief Pain Inventory with two added questions about side-effects of medication , the EORTC QLQ-C@-PAL and QLQ-BM@ for quality of life ) at baseline , daily for two weeks and lastly at four weeks .", "sentence_id": 13}
+{"abstract_id": "24885354", "label": "conclusions", "text": "This study will show whether dexamethasone is effective in preventing a pain flare after palliative radiotherapy for painful bone metastases and , if so , to determine the optimal dose .", "sentence_id": 14}
+{"abstract_id": "25938633", "label": "background", "text": "HIV infection is associated with a greater risk for fasting hyperinsulinemia , impaired glucose tolerance , and higher incidence rates for vascular disease , myocardial infarction , or stroke despite effective combination antiretroviral therapy ( cART ) .", "sentence_id": 0}
+{"abstract_id": "25938633", "label": "background", "text": "The underlying mechanism ( s ) may involve chronic low-grade systemic inflammation and immune cell activation .", "sentence_id": 1}
+{"abstract_id": "25938633", "label": "background", "text": "Dipeptidyl peptidase-@ inhibitors ( sitagliptin ) improve glucose tolerance and may possess immunomodulatory effects because leukocyte CD@ cell surface receptors express dipeptidyl peptidase-@ activity .", "sentence_id": 2}
+{"abstract_id": "25938633", "label": "objective", "text": "Sitagliptin will reduce inflammatory and immune cell activation markers known to be elevated in cART-treated HIV-infected ( HIV + ) adults with impaired glucose tolerance .", "sentence_id": 3}
+{"abstract_id": "25938633", "label": "methods", "text": "This was designed as a prospective , randomized , placebo-controlled , double-blind trial of sitagliptin in HIV + adults .", "sentence_id": 4}
+{"abstract_id": "25938633", "label": "methods", "text": "The setting was an academic medical center .", "sentence_id": 5}
+{"abstract_id": "25938633", "label": "methods", "text": "Patients were cART-treated HIV + men and women ( n = @ ) with stable HIV disease and impaired glucose tolerance .", "sentence_id": 6}
+{"abstract_id": "25938633", "label": "methods", "text": "Interventions included sitagliptin @ mg/d or placebo for @ weeks .", "sentence_id": 7}
+{"abstract_id": "25938633", "label": "methods", "text": "At baseline and week @ , plasma high-sensitivity C-reactive protein and C-X-C motif chemokine @ concentrations ( ELISA ) , oral glucose tolerance , and abdominal sc adipose mRNA expression for M@ macrophage markers ( monocyte chemotactic protein-@ , EGF-like module-containing , mucin-like hormone receptor @ ) .", "sentence_id": 8}
+{"abstract_id": "25938633", "label": "results", "text": "Sitagliptin reduced glucose area under the curve ( P = @ ) and improved oral glucose insulin sensitivity index ( P = @ ) more than placebo .", "sentence_id": 9}
+{"abstract_id": "25938633", "label": "results", "text": "Sitagliptin reduced plasma high-sensitivity C-reactive protein and C-X-C motif chemokine @ levels more than placebo ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25938633", "label": "results", "text": "Adipose tissue monocyte chemotactic protein-@ mRNA abundance declined significantly more ( P = @ ) , and adipose EGF-like module-containing , mucin-like hormone receptor @ mRNA expression tended to decline more ( P = @ ) in sitagliptin than placebo .", "sentence_id": 11}
+{"abstract_id": "25938633", "label": "conclusions", "text": "Sitagliptin had beneficial systemic and adipose anti-inflammatory effects in cART-treated HIV + adults with impaired glucose tolerance .", "sentence_id": 12}
+{"abstract_id": "25938633", "label": "conclusions", "text": "Large-scale , long-term studies should determine whether sitagliptin reduces cardiovascular risk and events in HIV + adults .", "sentence_id": 13}
+{"abstract_id": "25108752", "label": "objective", "text": "The purpose of this study was to compare the effects of manual therapy with exercise to kinesiotaping with exercise for patients with subacromial impingement syndrome .", "sentence_id": 0}
+{"abstract_id": "25108752", "label": "methods", "text": "Randomized clinical before and after trial was used .", "sentence_id": 1}
+{"abstract_id": "25108752", "label": "methods", "text": "Fifty-four patients diagnosed as having subacromial impingement syndrome who were referred for outpatient treatment were included .", "sentence_id": 2}
+{"abstract_id": "25108752", "label": "methods", "text": "Eligible patients ( between @ and @ years old , with unilateral shoulder pain ) were randomly allocated to @ study groups : kinesiotaping with exercise ( n = @ ) or manual therapy with exercise ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25108752", "label": "methods", "text": "In addition , patients were advised to use cold packs @ times per day to control for pain .", "sentence_id": 4}
+{"abstract_id": "25108752", "label": "methods", "text": "Visual analog scale for pain , Disability of Arm and Shoulder Questionnaire for function , and diagnostic ultrasound assessment for supraspinatus tendon thickness were used as main outcome measures .", "sentence_id": 5}
+{"abstract_id": "25108752", "label": "methods", "text": "Assessments were applied at the baseline and after completing @ weeks of related interventions .", "sentence_id": 6}
+{"abstract_id": "25108752", "label": "results", "text": "At the baseline , there was no difference between the @ group characteristics ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25108752", "label": "results", "text": "There were significant differences in both groups before and after treatment in terms of pain decrease and improvement of Disability of Arm and Shoulder Questionnaire scores ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25108752", "label": "results", "text": "No difference was observed on ultrasound for tendon thickness after treatment in both groups ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25108752", "label": "results", "text": "The only difference between the groups was at night pain , resulting in favor of the kinesiotaping with exercise group ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25108752", "label": "conclusions", "text": "For the group of subjects studied , no differences were found between kinesiotaping with exercise and manual therapy with exercise .", "sentence_id": 11}
+{"abstract_id": "25108752", "label": "conclusions", "text": "Both treatments may have similar results in reducing pain and disability in subacromial impingement in @ weeks .", "sentence_id": 12}
+{"abstract_id": "24886676", "label": "background", "text": "Men who undergo surgery for prostate cancer frequently experience significant side-effects including urinary and sexual dysfunction .", "sentence_id": 0}
+{"abstract_id": "24886676", "label": "background", "text": "These difficulties can lead to anxiety , depression and reduced quality of life .", "sentence_id": 1}
+{"abstract_id": "24886676", "label": "background", "text": "Many partners also experience psychological distress .", "sentence_id": 2}
+{"abstract_id": "24886676", "label": "background", "text": "An additional impact can be on the couple relationship , with changes to intimacy , and unmet psychosexual supportive needs in relation to sexual recovery and rehabilitation .", "sentence_id": 3}
+{"abstract_id": "24886676", "label": "background", "text": "The aim of this exploratory randomised controlled trial pilot study is to determine the feasibility and acceptability of a novel family-relational-psychosexual intervention to support intimacy and reduce distress among couples following prostate cancer surgery and to estimate the efficacy of this intervention .", "sentence_id": 4}
+{"abstract_id": "24886676", "label": "methods", "text": "The intervention will comprise six sessions of psychosexual and relationship support delivered by experienced couple-support practitioners .", "sentence_id": 5}
+{"abstract_id": "24886676", "label": "methods", "text": "Specialist training in delivering the intervention will be provided to practitioners and they will be guided by a detailed treatment manual based on systemic principles .", "sentence_id": 6}
+{"abstract_id": "24886676", "label": "methods", "text": "Sixty-eight couples will be randomised to receive either the intervention or standard care ( comprising usual follow-up hospital appointments ) .", "sentence_id": 7}
+{"abstract_id": "24886676", "label": "methods", "text": "A pre-test , post-test design will be used to test the feasibility of the intervention ( baseline , end of intervention and six-month follow-up ) and its acceptability to couples and healthcare professionals ( qualitative interviews ) .", "sentence_id": 8}
+{"abstract_id": "24886676", "label": "methods", "text": "Both individual and relational outcome measures will assess sexual functioning , anxiety and depression , couple relationship , use of health services and erectile dysfunction medication/technologies .", "sentence_id": 9}
+{"abstract_id": "24886676", "label": "methods", "text": "An economic analysis will estimate population costs of the intervention , compared to usual care , using simple modelling to evaluate the affordability of the intervention .", "sentence_id": 10}
+{"abstract_id": "24886676", "label": "conclusions", "text": "Given the increasing incidence and survival of post-operative men with prostate cancer , it is timely and appropriate to determine the feasibility of a definitive trial through a pilot randomised controlled trial of a family-relational-psychosexual intervention for couples .", "sentence_id": 11}
+{"abstract_id": "24886676", "label": "conclusions", "text": "The study will provide evidence about the components of a couple-based intervention , its acceptability to patients and healthcare professionals , and its influence on sexual and relational functioning .", "sentence_id": 12}
+{"abstract_id": "24886676", "label": "conclusions", "text": "Data from this study will be used to calculate sample sizes required for any definitive trial .", "sentence_id": 13}
+{"abstract_id": "24606601", "label": "background", "text": "The possibility of living well with a long-term condition has been identified as centrally relevant to the needs of people living with dementia .", "sentence_id": 0}
+{"abstract_id": "24606601", "label": "background", "text": "Growing numbers of people with early-stage dementia are contributing accounts that emphasise the benefits of actively engaging in managing the condition .", "sentence_id": 1}
+{"abstract_id": "24606601", "label": "background", "text": "Self-management interventions share the common objectives of educating about the condition , optimising well-being , enhancing control over the situation and enabling people to take more responsibility for managing the condition .", "sentence_id": 2}
+{"abstract_id": "24606601", "label": "background", "text": "Benefits of such an approach can include improved knowledge , self-efficacy , health status , and better performance of self-management behaviours .", "sentence_id": 3}
+{"abstract_id": "24606601", "label": "background", "text": "However , there is only preliminary evidence that people with early-stage dementia can benefit from such interventions .", "sentence_id": 4}
+{"abstract_id": "24606601", "label": "methods", "text": "This feasibility study involves the development of a self-management group intervention for people with early-stage Alzheimer 's disease , vascular dementia or mixed Alzheimer 's and vascular dementia .", "sentence_id": 5}
+{"abstract_id": "24606601", "label": "methods", "text": "This study is a single-site pilot randomised-controlled trial .", "sentence_id": 6}
+{"abstract_id": "24606601", "label": "methods", "text": "Forty-two people with early stage dementia , each with a caregiver ( family member/friend ) , will be randomised to either the self-management group intervention or to treatment as usual.The self-management group intervention will involve eight weekly sessions , each lasting @ minutes , held at a memory clinic in North Wales .", "sentence_id": 7}
+{"abstract_id": "24606601", "label": "methods", "text": "All participants will be re-assessed three and six months post-randomisation .", "sentence_id": 8}
+{"abstract_id": "24606601", "label": "methods", "text": "This study is intended to supply an early evaluation of the self-management intervention so that a full scale trial may be powered from the best available evidence .", "sentence_id": 9}
+{"abstract_id": "24606601", "label": "methods", "text": "It will assess the feasibility of the intervention , the study design and the recruitment strategies .", "sentence_id": 10}
+{"abstract_id": "24606601", "label": "methods", "text": "It will estimate the parameters and confidence intervals for the research questions of interest .", "sentence_id": 11}
+{"abstract_id": "24606601", "label": "methods", "text": "The primary outcome of interest is the self-efficacy score of the person with dementia at three months post-randomisation .", "sentence_id": 12}
+{"abstract_id": "24606601", "label": "methods", "text": "Secondary outcomes for the person with dementia are self-efficacy at six months post-randomisation and cognitive ability , mood and well-being at three and six months post-randomisation .", "sentence_id": 13}
+{"abstract_id": "24606601", "label": "methods", "text": "Secondary outcomes for caregivers are their distress and stress at three and six months post-randomisation .", "sentence_id": 14}
+{"abstract_id": "24606601", "label": "methods", "text": "The cost-effectiveness of the intervention will also be examined .", "sentence_id": 15}
+{"abstract_id": "24606601", "label": "conclusions", "text": "This study will provide preliminary information about the feasibility , efficacy and cost-effectiveness of a self-management group intervention for people in the early stages of dementia .", "sentence_id": 16}
+{"abstract_id": "24720535", "label": "background", "text": "Inflammation may contribute to the high cardiovascular risk in diabetes mellitus ( DM ) and chronic kidney disease ( CKD ) .", "sentence_id": 0}
+{"abstract_id": "24720535", "label": "background", "text": "Monocyte chemoattractant protein-@ ( MCP-@ ) facilitates the recruitment of monocytes into atherosclerotic lesions and is involved in diabetic nephropathy .", "sentence_id": 1}
+{"abstract_id": "24720535", "label": "background", "text": "Interferon gamma ( IFN ) is important in atherosclerosis and increases the synthesis of chemokines including MCP-@ .", "sentence_id": 2}
+{"abstract_id": "24720535", "label": "background", "text": "Lipid-lowering treatment ( LLT ) with statins may have anti-inflammatory effects , and ezetimibe cotreatment provides additional cholesterol lowering .", "sentence_id": 3}
+{"abstract_id": "24720535", "label": "methods", "text": "After a placebo run-in period , the effects of simvastatin alone ( S ) or simvastatin + ezetimibe ( S+E ) were compared in a randomized , double-blind , cross-over study on inflammatory parameters .", "sentence_id": 4}
+{"abstract_id": "24720535", "label": "methods", "text": "Eighteen DM patients with estimated glomerular filtration rate ( eGFR ) @-@mL / min@m ( @ ) ( CKD stages @-@ ) ( DM-CKD ) and @ DM patients with eGFR > @mL/min ( DM only ) were included .", "sentence_id": 5}
+{"abstract_id": "24720535", "label": "results", "text": "At baseline , monocyte chemoattractant protein @ ( MCP-@ ) ( P = @ ) , IFN ( P = @ ) , tumour necrosis factor - ( TNF ) ( P < @ ) and soluble vascular adhesion molecule ( sVCAM ) ( P = @ ) levels were elevated in DM-CKD compared with DM-only patients .", "sentence_id": 6}
+{"abstract_id": "24720535", "label": "results", "text": "LLT with S and S+E reduced MCP-@ levels ( P < @ by anova ) and IFN levels ( P < @ ) in DM-CKD patients but not in DM-only patients .", "sentence_id": 7}
+{"abstract_id": "24720535", "label": "results", "text": "Reductions were most pronounced with the combination treatment .", "sentence_id": 8}
+{"abstract_id": "24720535", "label": "conclusions", "text": "DM patients with CKD stages @-@ had increased inflammatory activity compared with DM patients with normal GFR .", "sentence_id": 9}
+{"abstract_id": "24720535", "label": "conclusions", "text": "Lipid-lowering treatment decreased the levels of MCP-@ and IFN in DM patients with concomitant CKD , which may be beneficial with regard to the progression of both atherosclerosis and diabetic nephropathy .", "sentence_id": 10}
+{"abstract_id": "24531987", "label": "background", "text": "Social connections at all stages of life are essential for physical and mental well-being .", "sentence_id": 0}
+{"abstract_id": "24531987", "label": "background", "text": "Of particular importance are social relationships during adolescence that shape adult health behaviors and health outcomes .", "sentence_id": 1}
+{"abstract_id": "24531987", "label": "objective", "text": "The aim of this study was to estimate the association between adolescent peer status in school and later-life quality-adjusted life-years ( QALYs ) and healthcare costs .", "sentence_id": 2}
+{"abstract_id": "24531987", "label": "methods", "text": "This study used social network and health outcomes data from Wave I ( ages @-@years ) and Wave III ( ages @-@years ) of the US National Longitudinal Study of Adolescent Health ( n = @,@ ) to compare QALYs and healthcare costs ( in @ US$ ) by adolescent peer status in US schools .", "sentence_id": 3}
+{"abstract_id": "24531987", "label": "methods", "text": "Generalized linear models controlled for school fixed effects , individual and family characteristics , and US census block neighborhood effects .", "sentence_id": 4}
+{"abstract_id": "24531987", "label": "methods", "text": "Non-parametric bootstrapping accounted for residual skewness in QALYs and healthcare costs .", "sentence_id": 5}
+{"abstract_id": "24531987", "label": "methods", "text": "Net monetary benefit ( NMB ) was calculated by converting adjusted @-year QALYs into US$ values and subtracting @-year healthcare costs .", "sentence_id": 6}
+{"abstract_id": "24531987", "label": "methods", "text": "NMB was then compared across quintiles of adolescent peer status in school at Wave I.", "sentence_id": 7}
+{"abstract_id": "24531987", "label": "results", "text": "Results obtained from non-parametric bootstrapping indicate that adolescents with higher peer status in school experience significantly better health and lower healthcare costs over the next @years .", "sentence_id": 8}
+{"abstract_id": "24531987", "label": "results", "text": "At US$ @,@ per QALY , adolescents with @ or more friends achieved NMB of US$ @,@ ( @ % CI @,@-@ ,@ ) over a @-year span , in comparison to adolescents with @-@ friends , who attained US$ @,@ ( @ % CI @,@-@ ,@ ) NMB .", "sentence_id": 9}
+{"abstract_id": "24531987", "label": "results", "text": "This difference translates into approximately US$ @,@ ( @ % CI @,@-@ ,@ ) per socially disengaged adolescent in additional health costs and/or reduced QALYs over @years .", "sentence_id": 10}
+{"abstract_id": "24531987", "label": "conclusions", "text": "The study calls for randomized controlled trials targeting adolescent peer group structures in schools as a means to promote better health and lower healthcare costs in adulthood .", "sentence_id": 11}
+{"abstract_id": "25529395", "label": "objective", "text": "Prediction of long-term outcomes in patients with community-acquired pneumonia ( CAP ) is incompletely understood .", "sentence_id": 0}
+{"abstract_id": "25529395", "label": "objective", "text": "We investigated the value of clinical risk scores -LSB- pneumonia severity index ( PSI ) and CURB-@ -RSB- ( Confusion , Urea , Respiratory rate , Blood Pressure , Age > @years ) and blood biomarkers of different physiopathological pathways in predicting long-term survival in a well-characterized cohort of patients with CAP enrolled in an antibiotic stewardship trial .", "sentence_id": 1}
+{"abstract_id": "25529395", "label": "methods", "text": "Patients admitted with CAP to six medical centres in Switzerland were prospectively followed for @years .", "sentence_id": 2}
+{"abstract_id": "25529395", "label": "methods", "text": "Cox regression models and area under the receiver operating characteristics curve ( AUC ) were used to investigate associations between initial risk assessment and all-cause mortality .", "sentence_id": 3}
+{"abstract_id": "25529395", "label": "methods", "text": "All-cause mortality during a @-year follow-up period .", "sentence_id": 4}
+{"abstract_id": "25529395", "label": "results", "text": "Six-year mortality in the present cohort ( median age @years ) was @ % -LSB- @ % confidence interval ( CI ) @-@ @ % -RSB- .", "sentence_id": 5}
+{"abstract_id": "25529395", "label": "results", "text": "Initial PSI and CURB-@ scores both had excellent long-term prognostic accuracy , with a stepwise increase in mortality per risk class .", "sentence_id": 6}
+{"abstract_id": "25529395", "label": "results", "text": "The hazard ratios ( @ % CI ) of the highest PSI and CURB-@ classes ( reference : lowest class ) were @ ( @-@ @ ) and @ ( @-@ @ ) , respectively , after @years .", "sentence_id": 7}
+{"abstract_id": "25529395", "label": "results", "text": "The addition of inflammatory ( pro-adrenomedullin ) and cardiac ( pro-atrial natriuretic peptide ) blood biomarkers measured upon hospital admission further improved the prognostic capabilities of the PSI ( AUC increase from @ to @ ; P < @ ) and the CURB-@ score ( AUC increase from @ to @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25529395", "label": "conclusions", "text": "Risk assessment using clinical scores allowed accurate long-term prognostication , which was further improved by the addition of two inflammatory ( pro-adrenomedullin ) and cardiac ( pro-atrial natriuretic peptide ) blood biomarkers .", "sentence_id": 9}
+{"abstract_id": "25529395", "label": "conclusions", "text": "These data provide a rationale for a more risk-adapted , ` personalized ' strategy for long-term management of patients with CAP .", "sentence_id": 10}
+{"abstract_id": "25872802", "label": "background", "text": "Because of limited impact on infant morbidity , mortality , and vitamin A status , the new guideline of the World Health Organization ( WHO ) does not recommend postpartum vitamin A supplementation ( VAS ) as a public health intervention in developing countries .", "sentence_id": 0}
+{"abstract_id": "25872802", "label": "background", "text": "However , breast milk contains numerous immune-protective components that are important for infant immune development , and several of these components are regulated by vitamin A.", "sentence_id": 1}
+{"abstract_id": "25872802", "label": "methods", "text": "Postpartum women are being enrolled within @days ( d ) of delivery at a maternity clinic located in a slum area of Dhaka city and randomized to one of four postpartum VAS regimens ( @/group , total @ ) .", "sentence_id": 2}
+{"abstract_id": "25872802", "label": "methods", "text": "The regimens are as follows : Group @ : @,@ IU VAS at < @ d and placebo at @weeks postpartum ; Group @ : placebo at < @ d and @,@ IU VAS at @weeks postpartum ; Group @ : @,@ IU VAS , both at < @ d and @weeks postpartum ; Group @ : placebo , both at < @ d and @weeks postpartum .", "sentence_id": 3}
+{"abstract_id": "25872802", "label": "methods", "text": "Breast milk samples at < @ d ( before supplementation ) and @months postpartum will be used to measure vitamin A and bioactive compounds .", "sentence_id": 4}
+{"abstract_id": "25872802", "label": "methods", "text": "Infant blood samples at @ and @months of age will be used to measure vitamin A , as well as innate and vaccine-specific immune responses .", "sentence_id": 5}
+{"abstract_id": "25872802", "label": "methods", "text": "Dietary , anthropometric , and morbidity data are also being collected .", "sentence_id": 6}
+{"abstract_id": "25872802", "label": "conclusions", "text": "This is the first placebo-controlled randomized clinical trial of postnatal vitamin A supplementation to investigate the key bioactive compounds in breast milk , important for infant immunity , in relation to dose and time point of postpartum supplementation and whether such maternal supplementation improves infant immune status during the critical period of early infancy .", "sentence_id": 7}
+{"abstract_id": "24398758", "label": "objective", "text": "To compare the therapeutic effects and adverse reactions of pemetrexed and docetaxel as salvage chemotherapy in patients with nonsmall-cell lung cancer ( NSCLC ) after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors ( EGFR-TKI ) .", "sentence_id": 0}
+{"abstract_id": "24398758", "label": "methods", "text": "In this randomized Phase @ trial , patients with NSCLC who had previously failed EGFR-TKI therapy were randomized to receive intravenous pemetrexed ( @mg/m ( @ ) for @ days -LSB- one cycle -RSB- ) or docetaxel ( @mg/m ( @ ) for @ days -LSB- one cycle -RSB- ) .", "sentence_id": 1}
+{"abstract_id": "24398758", "label": "methods", "text": "Therapeutic effects were evaluated according to Response Evaluation Criteria in Solid Tumours standards and adverse effects were evaluated according to the US National Cancer Institute Common Terminology Criteria for Adverse Events .", "sentence_id": 2}
+{"abstract_id": "24398758", "label": "results", "text": "There was no statistically significant difference in disease control rate , response rate , median survival and @-year survival between treatment groups .", "sentence_id": 3}
+{"abstract_id": "24398758", "label": "results", "text": "Rates of nausea , myelosuppression , renal damage and hair loss were significantly higher in the docetaxel group than the pemetrexed group .", "sentence_id": 4}
+{"abstract_id": "24398758", "label": "conclusions", "text": "Pemetrexed is effective and well tolerated as salvage chemotherapy in patients with NSCLC after EGFR-TKI failure and may be a suitable therapeutic option in these patients .", "sentence_id": 5}
+{"abstract_id": "25048075", "label": "objective", "text": "Long-term physical activity is reported to improve chronic systemic inflammation , which provides protection against the ensuing development of chronic disease .", "sentence_id": 0}
+{"abstract_id": "25048075", "label": "objective", "text": "Accordingly , the present study assessed changes in pro- and anti-inflammatory cytokines , aerobic capacity and body composition following @ weeks of either small-sided games ( SSG ) or cycling ( CYC ) training compared to a sedentary control ( CON ) condition .", "sentence_id": 1}
+{"abstract_id": "25048075", "label": "methods", "text": "Thirty-three middle-aged , sedentary men were randomized into CYC ( n = @ ) , SSG ( n = @ ) , or CON ( n = @ ) conditions .", "sentence_id": 2}
+{"abstract_id": "25048075", "label": "methods", "text": "The CYC and SSG conditions trained @ days/week for @ weeks , whilst CON maintained habitual activity and dietary patterns .", "sentence_id": 3}
+{"abstract_id": "25048075", "label": "methods", "text": "Pre - and post-intervention testing included a dual-energy X-ray absorptiometry scan , sub-maximal ( @ % maximal heart rate ) aerobic capacity ( VO ) and fasting venous blood .", "sentence_id": 4}
+{"abstract_id": "25048075", "label": "methods", "text": "Venous blood measures for pro-inflammatory markers included C-reactive protein ( CRP ) , interleukin ( IL ) -@ , IL-@ , tumor necrosis factor - , and leptin ; anti-inflammatory markers included IL-@ , IL-@ receptor agonist , and adiponectin .", "sentence_id": 5}
+{"abstract_id": "25048075", "label": "results", "text": "Both CYC and SSG increased submaximal power output and VO ( P < @ ) , decreased total body fat-mass ( TB-FM ; P < @ ) , and CRP ( SSG , -@ @ mg L ( -@ ) ; P = @ ; CYC , -@ @ mg L ( -@ ) ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25048075", "label": "results", "text": "Only SSG increased total body fat-free mass ( TB-FFM ; +@ @ kg ; P = @ ) and decreased concentration of plasma IL-@ ( -@ @ pg mL ( -@ ) ; P = @ ) and leptin ( -@,@ @,@ ng mL ( -@ ) ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25048075", "label": "conclusions", "text": "Cycling and SSG training were both effective at improving CRP , VO and TB-FM .", "sentence_id": 8}
+{"abstract_id": "25048075", "label": "conclusions", "text": "Furthermore , SSG training has also shown to be an effective training approach in reducing IL-@ and leptin and increasing muscle mass within sedentary , middle-aged men .", "sentence_id": 9}
+{"abstract_id": "25290608", "label": "objective", "text": "To determine whether a cyromazine-resistant strain of Lucilia cuprina was able to establish strikes sooner than a susceptible strain on cyromazine - or dicyclanil-treated sheep .", "sentence_id": 0}
+{"abstract_id": "25290608", "label": "methods", "text": "Groups of @ sheep were treated with cyromazine or dicyclanil in accordance with label directions .", "sentence_id": 1}
+{"abstract_id": "25290608", "label": "methods", "text": "Beginning @ weeks after treatment , @ sheep from each group were challenged by implantation of neonate larvae belonging to the cyromazine-resistant strain ` Nimmitabel-selected ' and the susceptible blowfly strain ` Field @ ' according to standard larval implant technique .", "sentence_id": 2}
+{"abstract_id": "25290608", "label": "methods", "text": "The implant sites were alternated between the shoulder , mid-back and rump within the treatment zone .", "sentence_id": 3}
+{"abstract_id": "25290608", "label": "methods", "text": "Similarly , implants of the resistant and susceptible strain larvae were alternated at each challenge such that the strain implanted on the left side of the sheep at one challenge was implanted on the right side at the next .", "sentence_id": 4}
+{"abstract_id": "25290608", "label": "methods", "text": "Challenges were conducted at @-weekly intervals until the susceptible larvae formed strikes on at least @ of the @ sheep in a treatment group or until @ weeks after treatment .", "sentence_id": 5}
+{"abstract_id": "25290608", "label": "results", "text": "Sheep treated with cyromazine or dicyclanil were protected from flystrike by the cyromazine-susceptible strain for periods consistent with , or longer than , the registered product label claims .", "sentence_id": 6}
+{"abstract_id": "25290608", "label": "results", "text": "The cyromazine-resistant strain created strikes several weeks sooner after treatment than did the susceptible strain .", "sentence_id": 7}
+{"abstract_id": "25290608", "label": "results", "text": "Accordingly , the protection periods provided by cyromazine and dicyclanil against the resistant strain were reduced from @ and @-@ weeks to < @ weeks and < @ weeks , respectively .", "sentence_id": 8}
+{"abstract_id": "25290608", "label": "conclusions", "text": "Resistance , even in the pure-breeding resistant strain , was not so severe as to cause treatment failure with cyromazine or dicyclanil , but was sufficient to reduce the protection period provided .", "sentence_id": 9}
+{"abstract_id": "25290608", "label": "conclusions", "text": "It is recommended that producers adopt management practices that minimise the development of resistance to these and other compounds .", "sentence_id": 10}
+{"abstract_id": "24343370", "label": "objective", "text": "Cardiopulmonary bypass ( CPB ) , utilized in on-pump coronary artery bypass graft procedures ( CABG ) induces generalized immune suppression , release of heat shock proteins ( HSP ) , inflammatory markers and apoptosis-specific proteins .", "sentence_id": 0}
+{"abstract_id": "24343370", "label": "objective", "text": "We hypothesized that continued mechanical ventilation during cardiopulmonary bypass attenuates immune response and HSP liberation .", "sentence_id": 1}
+{"abstract_id": "24343370", "label": "methods", "text": "Thirty patients undergoing conventional coronary artery bypass graft ( CABG ) operation were randomized into a ventilated on CPB ( VG ; N. = @ ) and a non-ventilated CPB group ( NVG ; N. = @ ) .", "sentence_id": 2}
+{"abstract_id": "24343370", "label": "methods", "text": "Blood samples were drawn at the beginning and end of surgery , as well as on the five consecutive postoperative days ( POD ) .", "sentence_id": 3}
+{"abstract_id": "24343370", "label": "methods", "text": "Molecular markers were measured by ELISA .", "sentence_id": 4}
+{"abstract_id": "24343370", "label": "methods", "text": "Data are given as mean ( SD ) .", "sentence_id": 5}
+{"abstract_id": "24343370", "label": "methods", "text": "Mann-Whitney-U-test was used for statistical analysis .", "sentence_id": 6}
+{"abstract_id": "24343370", "label": "results", "text": "Serum concentrations of HSP@ were significantly lower in VG compared to NVG on POD-@ ( VG : @ vs. NVG : @ pg/mL , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24343370", "label": "results", "text": "HSP@ and HSP@ depicted a minor increase in both study groups at the end of surgery without any intergroup differences ( HSP@ : VG @ vs. NVG @ ; HSP@ : VG @ vs. NVG @ ) .", "sentence_id": 8}
+{"abstract_id": "24343370", "label": "results", "text": "IL-@ and CK-@ M@ evidenced the highest serum concentrations at the end of surgery ( IL-@ : VG @ vs. NVG @ ; CK-@ M@ : VG @ vs. NVG @ ) with no differences between groups .", "sentence_id": 9}
+{"abstract_id": "24343370", "label": "results", "text": "Decreased ICAM-@ serum concentrations were detected postoperatively , however ICAM-@ concentrations on POD-@ to POD-@ showed slightly elevated concentrations in both study groups with no intergroup differences .", "sentence_id": 10}
+{"abstract_id": "24343370", "label": "conclusions", "text": "Significantly less HSP@ was detectable in patients receiving uninterrupted mechanical lung ventilation on CPB , indicating either different inflammatory response , cellular stress or cell damage between the ventilated and non-ventilated group .", "sentence_id": 11}
+{"abstract_id": "24343370", "label": "conclusions", "text": "These data suggest that continued mechanical ventilation has a modulatory effect on the immune response in patients after CABG surgery .", "sentence_id": 12}
+{"abstract_id": "24755148", "label": "background", "text": "Time in therapeutic range ( TTR ) is a standard quality measure of the use of warfarin .", "sentence_id": 0}
+{"abstract_id": "24755148", "label": "background", "text": "We assessed the relative effects of rivaroxaban versus warfarin at the level of trial center TTR ( cTTR ) since such analysis preserves randomized comparisons .", "sentence_id": 1}
+{"abstract_id": "24755148", "label": "results", "text": "TTR was calculated using the Rosendaal method , without exclusion of international normalized ratio ( INR ) values performed during warfarin initiation .", "sentence_id": 2}
+{"abstract_id": "24755148", "label": "results", "text": "Measurements during warfarin interruptions > @ days were excluded .", "sentence_id": 3}
+{"abstract_id": "24755148", "label": "results", "text": "INRs were performed via standardized finger-stick point-of-care devices at least every @ weeks .", "sentence_id": 4}
+{"abstract_id": "24755148", "label": "results", "text": "The primary efficacy endpoint ( stroke or non-central nervous system embolism ) was examined by quartiles of cTTR and by cTTR as a continuous function .", "sentence_id": 5}
+{"abstract_id": "24755148", "label": "results", "text": "Centers with the highest cTTRs by quartile had lower-risk patients as reflected by lower CHADS@ scores ( P < @ ) and a lower prevalence of prior stroke or transient ischemic attack ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24755148", "label": "results", "text": "Sites with higher cTTR were predominantly from North America and Western Europe .", "sentence_id": 7}
+{"abstract_id": "24755148", "label": "results", "text": "The treatment effect of rivaroxaban versus warfarin on the primary endpoint was consistent across a wide range of cTTRs ( P value for interaction = @ ) .", "sentence_id": 8}
+{"abstract_id": "24755148", "label": "results", "text": "The hazard of major and non-major clinically relevant bleeding increased with cTTR ( P for interaction = @ ) , however , the estimated reduction by rivaroxaban compared with warfarin in the hazard of intracranial hemorrhage was preserved across a wide range of threshold cTTR values .", "sentence_id": 9}
+{"abstract_id": "24755148", "label": "conclusions", "text": "The treatment effect of rivaroxaban compared with warfarin for the prevention of stroke and systemic embolism is consistent regardless of cTTR .", "sentence_id": 10}
+{"abstract_id": "24703319", "label": "background", "text": "The prognostic utility of vascular endothelial growth factor A ( VEGF-A ) splice variants in patients with advanced breast cancer treated with bevacizumab has not been studied .", "sentence_id": 0}
+{"abstract_id": "24703319", "label": "methods", "text": "A total of @ patients with metastatic breast cancer treated with weekly docetaxel or ixabepilone without bevacizumab ( cohort A ) and @ treated with weekly paclitaxel and bevacizumab ( cohort B ) were studied .", "sentence_id": 1}
+{"abstract_id": "24703319", "label": "methods", "text": "Formalin-fixed tumors were macrodissected for reverse transcription quantitative polymerase chain reaction relative quantification of VEGF-A@ , -@ , and -@ isoforms spliced at exon @ proximal splice site ( VEGF-Axxxa ) and at exon @ distal splice site ( VEGF-Axxxb ) .", "sentence_id": 2}
+{"abstract_id": "24703319", "label": "results", "text": "For high VEGF-Axxxa , the hazard ratios ( HRs ) for progression were @ ( P = @ ) in non-bevacizumab-treated patients ( cohort A ) and @ ( P = @ ) in bevacizumab-treated patients ( cohort B ) , and the HRs for death were @ ( P = @ ) and @ ( P = @ ) , respectively .", "sentence_id": 3}
+{"abstract_id": "24703319", "label": "results", "text": "The interaction of VEGF-Axxxa with bevacizumab administration was significant ( P = @ ) for overall survival ( OS ) .", "sentence_id": 4}
+{"abstract_id": "24703319", "label": "results", "text": "High tissue VEGF-Axxxb was not prognostic in cohort A but was predictive for bevacizumab benefit in cohort B ( HR for progression , @ -LSB- P = @ -RSB- ; HR for death , @ -LSB- P = @ -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "24703319", "label": "results", "text": "Exploratory analyses done only in cohort B suggested that abundance of VEGFR@ messenger RNA ( mRNA ) in peripheral blood and low VEGFR@ mRNA in tissue correlated with poor outcome .", "sentence_id": 6}
+{"abstract_id": "24703319", "label": "results", "text": "In multivariate analysis , high tissue mRNA of angiogenic VEGF-Axxxa in the presence of bevacizumab therapy predicted for favorable progression-free survival ( HR for progression , @ ; P = @ ) and OS ( HR for death , @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24703319", "label": "conclusions", "text": "Tissue mRNA expression of angiogenic VEGF-Axxxa isoforms was retrospectively associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered in patients with advanced breast cancer .", "sentence_id": 8}
+{"abstract_id": "24753534", "label": "objective", "text": "Although anxiety is common in children with attention-deficit/hyperactivity disorder ( ADHD ) , it is unclear how anxiety influences the lives of these children .", "sentence_id": 0}
+{"abstract_id": "24753534", "label": "objective", "text": "This study examined the association between anxiety comorbidities and functioning by comparing children with ADHD and no , @ , or @ anxiety comorbidities .", "sentence_id": 1}
+{"abstract_id": "24753534", "label": "objective", "text": "Differential associations were examined by current ADHD presentation ( subtype ) .", "sentence_id": 2}
+{"abstract_id": "24753534", "label": "methods", "text": "Children with diagnostically confirmed ADHD ( N = @ ; @-@ years ) were recruited via @ pediatrician practices across Victoria , Australia .", "sentence_id": 3}
+{"abstract_id": "24753534", "label": "methods", "text": "Anxiety was assessed by using the Anxiety Disorders Interview Schedule for Children-IV .", "sentence_id": 4}
+{"abstract_id": "24753534", "label": "methods", "text": "Functional measures included parent-reported : quality of life ( QoL ; Pediatric Quality of Life Inventory @ ) , behavior and peer problems ( Strengths and Difficulties Questionnaire ) , daily functioning ( Daily Parent Rating of Evening and Morning Behavior ) , and school attendance .", "sentence_id": 5}
+{"abstract_id": "24753534", "label": "methods", "text": "Teacher-reported behavior and peer problems ( Strengths and Difficulties Questionnaire ) were also examined .", "sentence_id": 6}
+{"abstract_id": "24753534", "label": "methods", "text": "Linear and logistic regression controlled for ADHD severity , medication use , comorbidities , and demographic factors .", "sentence_id": 7}
+{"abstract_id": "24753534", "label": "results", "text": "Children with @ anxiety comorbidities ( n = @ ; @ % ) had poorer QoL ( effect size : -@ ) and more difficulties with behavior ( effect size : @ ) and daily functioning ( effect size : @ ) than children without anxiety ( n = @ ; @ % ) .", "sentence_id": 8}
+{"abstract_id": "24753534", "label": "results", "text": "Poorer functioning was not observed for children with @ anxiety comorbidity ( n = @ ; @ % ) .", "sentence_id": 9}
+{"abstract_id": "24753534", "label": "results", "text": "Two or more anxiety comorbidities were associated with poorer functioning for children with both ADHD-Inattentive and ADHD-Combined presentation .", "sentence_id": 10}
+{"abstract_id": "24753534", "label": "conclusions", "text": "Children with ADHD demonstrate poorer QoL , daily functioning and behavior when @ anxiety comorbidities are present .", "sentence_id": 11}
+{"abstract_id": "24753534", "label": "conclusions", "text": "Future research should examine whether treating anxiety in children with ADHD improves functional outcomes .", "sentence_id": 12}
+{"abstract_id": "24857044", "label": "background", "text": "The role of human equilibrative nucleoside transporter @ ( hENT@ ) as a predictive biomarker for gemcitabine efficacy in advanced pancreatic cancer remains unclear to date .", "sentence_id": 0}
+{"abstract_id": "24857044", "label": "methods", "text": "AIO-PK@ was a German multicenter phase III trial comparing gemcitabine/erlotinib followed by capecitabine ( GEC ) with capecitabine/erlotinib followed by gemcitabine ( CEG ) in advanced pancreatic cancer .", "sentence_id": 1}
+{"abstract_id": "24857044", "label": "methods", "text": "Archival tumour tissue from @ of the @ eligible study patients was available for a central and standardised immunohistochemistry staining for hENT@ expression using the SP@ rabbit monoclonal anti-hENT@ antibody .", "sentence_id": 2}
+{"abstract_id": "24857044", "label": "methods", "text": "Within a retrospective translational subgroup analysis , biomarker data were correlated with efficacy end-points .", "sentence_id": 3}
+{"abstract_id": "24857044", "label": "results", "text": "Thirty-nine out of @ fresh-cut slides were scored as hENT@ ( high ) ( @ % ) , whereas @ samples were classified as hENT@ ( low ) ( @ % ) .", "sentence_id": 4}
+{"abstract_id": "24857044", "label": "results", "text": "For the @ patients randomised to CEG median overall survival was estimated with @ months in the hENT@ ( low ) compared to @ months in the hENT@ ( high ) subgroup ( Hazard Ratio ( HR ) @ , @ % confidence interval ( CI ) @-@ @ , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24857044", "label": "results", "text": "For the @ patients randomised to GEC survival was @ months in the hENT@ ( low ) compared to @ months in the hENT@ ( high ) subgroup ( HR @ , @ % CI @-@ @ , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24857044", "label": "results", "text": "In @ patients receiving gemcitabine at any time during study treatment ( either within the @st - or @nd-line setting ) hENT@ ( low ) cases had a median overall survival of @ months and hENT@ ( high ) patients an overall survival of @ months ( HR @ , @ % CI @-@ @ , p = @ ) , respectively .", "sentence_id": 7}
+{"abstract_id": "24857044", "label": "conclusions", "text": "Within this subgroup analysis from Arbeitsgemeinschaft Internistische Onkologie-pancreatic cancer ( AIO-PK@ ) , no evidence supporting the use of hENT@ as a predictive biomarker for gemcitabine efficacy in patients with advanced pancreatic cancer was found .", "sentence_id": 8}
+{"abstract_id": "24268371", "label": "objective", "text": "This study aimed to compare the efficacy and safety of bismuth-included standard regimen and modified sequential treatments in Turkey , where the success rate of standard triple therapy is very low .", "sentence_id": 0}
+{"abstract_id": "24268371", "label": "methods", "text": "One-hundred and sixty patients with dyspeptic complaints and nave Helicobacter pylori infection were randomized into four groups : @ patients received standard @-day quadruple treatment ( STD ) ( Rabeprazole @mg-bid , bismuth subcitrate ( @ mg-qid ) , Tetracycline @ mg-qid , Metronidazole @ mg-tid ) for @ weeks .", "sentence_id": 1}
+{"abstract_id": "24268371", "label": "methods", "text": "The modified sequential therapy groups received @ mg rabeprazole and @g amoxicillin , twice daily for the first @ days , followed by Rabeprazole @mg-bid , bismuth subcitrate ( @ mg-qid ) , Tetracycline @ mg-qid , Metronidazole @ mg-tid for the remaining @ ( @ day sequential therapy group-@S ) ( @ patients ) , @ ( @ day sequential therapy group-@S ) ( @ patients ) and @ ( @ day sequential therapy group-@S ) ( @ patients ) days .", "sentence_id": 2}
+{"abstract_id": "24268371", "label": "results", "text": "The overall compliance and H. pylori eradication rate among the @ patients who completed the H. pylori eradication regimens were @ % ( @/@ ) and @ % ( @/@ ) , respectively .", "sentence_id": 3}
+{"abstract_id": "24268371", "label": "results", "text": "The results were not statistically different between groups in the eradication rates .", "sentence_id": 4}
+{"abstract_id": "24268371", "label": "results", "text": "Per-protocol eradication rates were @ % in STD , @ % in @S , @ % in @S and @ % in @S groups ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "24268371", "label": "results", "text": "Intention-to-treatment rates were @ % in STD , @ % in @S , @ % in @S and @ % in @S groups ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24268371", "label": "conclusions", "text": "The eradication rates of standard @-day and different sequential quadruple treatment regimens are comparable and much more higher than with standard @-day triple H. pylori eradication treatment that has been reported previously in Turkey .", "sentence_id": 7}
+{"abstract_id": "24713632", "label": "background", "text": "Restrictive , very low-energy diets focused on rapid weight loss have proven to be effective in improving asthma outcome in obese patients , but their use in children and pubescents is controversial due its potential consequences in growth .", "sentence_id": 0}
+{"abstract_id": "24713632", "label": "background", "text": "More conservative , normocaloric schemes are suggested as a more suitable dietary approach for these patients .", "sentence_id": 1}
+{"abstract_id": "24713632", "label": "methods", "text": "A randomized clinical trial was run of @ pubertal adolescents with asthma and obesity , who were allocated to either an interventional @-week program of normocaloric diet based on normal requirements for height and meal planning ( n = @ ) or a non-interventional ( free diet ) control group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24713632", "label": "methods", "text": "Asthma-related quality of life ( AR-QOL , assessed by the Standardized Pediatric Asthma Quality of Life Questionnaire , PAQLQ -LSB- S -RSB- ) and clinical indicators of asthma control were measured before and after the intervention period .", "sentence_id": 3}
+{"abstract_id": "24713632", "label": "results", "text": "Diet intervention was associated with a significant improvement in AR-QOL in relation to baseline ( PAQLQ -LSB- S -RSB- scores ) compared with controls , both in overall score ( p < @ ) and its subdomains ( activity limitation , p < @ ; symptoms , p < @ ; emotional function , p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24713632", "label": "results", "text": "The group with normocaloric diet observed a significant decrease in body mass index z-score , which correlated positively with the improvement in AR-QOL ( Spearman 's r = @ , p < @ ) , in addition to have significantly fewer events of acute attacks of asthma and nighttime awakenings , plus a non-significant reduction in the use of inhaled corticosteroids .", "sentence_id": 5}
+{"abstract_id": "24713632", "label": "results", "text": "No significant changes were observed in the pulmonary function tests .", "sentence_id": 6}
+{"abstract_id": "24713632", "label": "conclusions", "text": "The normocaloric dietary intervention was associated with improvement of AR-QOL and some aspects of asthma control .", "sentence_id": 7}
+{"abstract_id": "24713632", "label": "conclusions", "text": "Such structured dietary programs could probably have a role as a complementary non-pharmacological therapeutic strategy in obese pubertal adolescents with asthma .", "sentence_id": 8}
+{"abstract_id": "24228747", "label": "background", "text": "Because of symptoms , people with lumbar spinal stenosis ( LSS ) are often inactive , and this sedentary behaviour implies risk for diseases including obesity .", "sentence_id": 0}
+{"abstract_id": "24228747", "label": "background", "text": "Research has identified body mass index as the most powerful predictor of function in LSS .", "sentence_id": 1}
+{"abstract_id": "24228747", "label": "background", "text": "This suggests that function may be improved by targeting weight as a modifiable factor .", "sentence_id": 2}
+{"abstract_id": "24228747", "label": "background", "text": "An e-health lifestyle intervention was developed aimed at reducing fat mass and increasing physical activity in people with LSS .", "sentence_id": 3}
+{"abstract_id": "24228747", "label": "background", "text": "The main components of this intervention include pedometer-based physical activity promotion and nutrition education .", "sentence_id": 4}
+{"abstract_id": "24228747", "label": "methods", "text": "The Spinal Stenosis Pedometer and Nutrition Lifestyle INTERVENTION ( SSPANLI ) was developed and piloted with @ individuals .", "sentence_id": 5}
+{"abstract_id": "24228747", "label": "methods", "text": "The protocol for a randomized controlled trail comparing the SSPANLI intervention to usual non-surgical care follows .", "sentence_id": 6}
+{"abstract_id": "24228747", "label": "methods", "text": "One hundred six ( @ ) overweight or obese individuals with LSS will be recruited .", "sentence_id": 7}
+{"abstract_id": "24228747", "label": "methods", "text": "Baseline and follow-up testing includes dual energy x-ray absorptiometry , blood draw , @-day food record , @-day accelerometry , questionnaire , maximal oxygen consumption , neurological exam , balance testing and a Self-Paced Walking Test .", "sentence_id": 8}
+{"abstract_id": "24228747", "label": "methods", "text": "During Week @ , the intervention group will receive a pedometer , and a personalized consultation with both a Dietitian and an exercise specialist .", "sentence_id": 9}
+{"abstract_id": "24228747", "label": "methods", "text": "For @ weeks participants will log on to the e-health website to access personal step goals , walking maps , nutrition videos , and motivational quotes .", "sentence_id": 10}
+{"abstract_id": "24228747", "label": "methods", "text": "Participants will also have access to in-person Coffee Talk meetings every @ weeks , and meet with the Dietitian and exercise specialist at week @ .", "sentence_id": 11}
+{"abstract_id": "24228747", "label": "methods", "text": "The control group will proceed with usual care for the @-week period .", "sentence_id": 12}
+{"abstract_id": "24228747", "label": "methods", "text": "Follow-up testing will occur at Weeks @ and @ .", "sentence_id": 13}
+{"abstract_id": "24228747", "label": "conclusions", "text": "This lifestyle intervention has the potential to provide a unique , non-surgical management option for people with LSS .", "sentence_id": 14}
+{"abstract_id": "24228747", "label": "conclusions", "text": "Through decreased fat mass and increased function , we may reduce risk for obesity , chronic diseases of inactivity , and pain .", "sentence_id": 15}
+{"abstract_id": "24228747", "label": "conclusions", "text": "The use of e-health interventions provides an opportunity for patients to become more involved in managing their own health .", "sentence_id": 16}
+{"abstract_id": "24228747", "label": "conclusions", "text": "Behaviour changes including increased physical activity , and improved dietary habits promote overall health and quality of life , and may decrease future health care needs in this population .", "sentence_id": 17}
+{"abstract_id": "24303967", "label": "background", "text": "In this study we hypothesized that signs of atypical atrial activation would be associated with cardiac resynchronization therapy ( CRT ) response in patients with mildly symptomatic heart failure ( CHF ) , left ventricular dysfunction , and wide QRS complex .", "sentence_id": 0}
+{"abstract_id": "24303967", "label": "methods", "text": "Patients included in the CRT-D arm in MADIT-CRT were studied ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24303967", "label": "methods", "text": "Unfiltered signal-averaged P waves were analyzed to determine orthogonal P-wave morphology ( typical morphologies were predefined as having positive signals in Leads X and Y and a negative or negative-positive signal in Lead Z. All other patterns were classified as atypical ) .", "sentence_id": 2}
+{"abstract_id": "24303967", "label": "methods", "text": "The association between P-wave morphology and data on echocardiographic response at @ year was analyzed .", "sentence_id": 3}
+{"abstract_id": "24303967", "label": "results", "text": "Atypical P-wave morphology was found in @ % ( n = @ ) of the patients at baseline .", "sentence_id": 4}
+{"abstract_id": "24303967", "label": "results", "text": "Patients with atypical P-wave morphology were more often female ( @ % vs. @ % , P = @ ) , had lower BMI ( @ @ kg/m ( @ ) vs. @ @ kg/m ( @ ) , P = @ ) , had more ischemic CHF ( @ % vs. @ % , P = @ ) and had smaller left atrial volumes ( @ @ mL vs. @ @ mL , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24303967", "label": "results", "text": "Atypical P-wave morphology at baseline was associated with superior response to CRT at @ year with a larger reduction in left ventricular end-diastolic volume ( -@ @ % vs. -@ @ % , P = @ ) , left ventricular end-systolic volume ( -@ @ % vs. -@ @ % , P = @ ) , and left atrial volume ( -@ @ % vs. -@ @ % , P = @ ) , with a slightly larger absolute increase in left ventricular ejection fraction ( LVEF ) ( @ @ % vs. @ @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24303967", "label": "results", "text": "These associations were found to be independent of traditional predictors .", "sentence_id": 7}
+{"abstract_id": "24303967", "label": "conclusions", "text": "The presence of atypical P-wave morphology recorded is independently associated with a favorable echocardiographic cardiac remodeling response to CRT .", "sentence_id": 8}
+{"abstract_id": "26467136", "label": "background", "text": "Classical laparoscopic cholecystectomy involves four ports while most novel ` single port ' technique only requires one incision on the abdominal wall .", "sentence_id": 0}
+{"abstract_id": "26467136", "label": "background", "text": "This technique is thought to decrease surgical trauma and improve cosmesis although there are reports pointing out that classical laparoscopic cholecystectomy is also feasible in terms of cosmesis .", "sentence_id": 1}
+{"abstract_id": "26467136", "label": "objective", "text": "In this study we tried to determine if there are certain advantages in quality of life after single port surgery which would justify its utilization instead of classical laparoscopic cholecystectomy .", "sentence_id": 2}
+{"abstract_id": "26467136", "label": "methods", "text": "This is aprospective randomized study which enrolled @ patients randomized either into classical laparoscopic cholecystectomy or single port surgery .", "sentence_id": 3}
+{"abstract_id": "26467136", "label": "methods", "text": "The primary endpoint was patient satisfaction after surgery .", "sentence_id": 4}
+{"abstract_id": "26467136", "label": "methods", "text": "This was assessed with short form @ and gastrointestinal quality of life index ( first preoperatively and then @months postoperatively ) and avisual analogue scale on the first and seventh days .", "sentence_id": 5}
+{"abstract_id": "26467136", "label": "results", "text": "There was not astatistically significant difference between groups in the emotional role , social functions , mental health , vitality and general health subscales of short form @ .", "sentence_id": 6}
+{"abstract_id": "26467136", "label": "results", "text": "At the end of @ weeks , both groups demonstrated increases in the gastrointestinal and social subscales of the gastrointestinal quality of life index .", "sentence_id": 7}
+{"abstract_id": "26467136", "label": "results", "text": "There was not astatistically significant difference between groups when the visual analogue scale scores on first and seventh days were compared .", "sentence_id": 8}
+{"abstract_id": "26467136", "label": "conclusions", "text": "The equal length of hospitalization , patient quality of life and pain perception and the longer operative times , high likelihood of incisional hernia and surgical site infection call into question the utilization of single port surgery , as it does not seem to confer an advantage over classical laparoscopic cholecystectomy .", "sentence_id": 9}
+{"abstract_id": "25468387", "label": "background", "text": "Iron deficiency anemia and serum phosphate levels > @ mg/dL are relatively common in chronic kidney disease stages @ to @ and are associated with higher risks of progressive loss of kidney function , cardiovascular events , and mortality .", "sentence_id": 0}
+{"abstract_id": "25468387", "label": "methods", "text": "Double-blind , placebo-controlled , randomized trial .", "sentence_id": 1}
+{"abstract_id": "25468387", "label": "methods", "text": "@ patients with estimated glomerular filtration rates < @ mL/min/@ @ m ( @ ) , iron deficiency anemia ( hemoglobin , @-@ @ g/dL ; transferrin saturation -LSB- TSAT -RSB- @ % , serum ferritin @ ng/mL ) , and serum phosphate levels @ to @ mg/dL .", "sentence_id": 2}
+{"abstract_id": "25468387", "label": "methods", "text": "Use of intravenous iron or erythropoiesis-stimulating agents was prohibited .", "sentence_id": 3}
+{"abstract_id": "25468387", "label": "methods", "text": "Randomization to treatment for @ weeks with ferric citrate coordination complex ( ferric citrate ) or placebo .", "sentence_id": 4}
+{"abstract_id": "25468387", "label": "methods", "text": "Coprimary end points were change in TSAT and serum phosphate level from baseline to end of study .", "sentence_id": 5}
+{"abstract_id": "25468387", "label": "methods", "text": "Secondary outcomes included change from baseline to end of treatment in values for ferritin , hemoglobin , intact fibroblast growth factor @ ( FGF-@ ) , urinary phosphate excretion , and estimated glomerular filtration rate .", "sentence_id": 6}
+{"abstract_id": "25468387", "label": "results", "text": "Ferric citrate treatment increased mean TSAT from @ % @ % ( SD ) to @ % @ % and reduced serum phosphate levels from @ @ to @ @ mg/dL , while placebo exerted no effect on TSAT ( @ % @ % to @ % @ % ) and less effect on serum phosphate level ( @ @ to @ @ mg/dL ; between-group P < @ for each ) .", "sentence_id": 7}
+{"abstract_id": "25468387", "label": "results", "text": "Ferric citrate increased hemoglobin levels ( from @ @ to @ @ g/dL ; P < @ vs placebo ) , reduced urinary phosphate excretion @ % ( P < @ vs placebo ) , and reduced serum intact FGF-@ levels from a median of @ ( IQR , @-@ ) to @ ( IQR , @-@ ) pg/mL ( P = @ vs placebo ) .", "sentence_id": 8}
+{"abstract_id": "25468387", "label": "results", "text": "The incidence and severity of adverse effects were similar between treatment arms .", "sentence_id": 9}
+{"abstract_id": "25468387", "label": "conclusions", "text": "The study is limited by relatively small sample size and short duration and by having biochemical rather than clinical outcomes .", "sentence_id": 10}
+{"abstract_id": "25468387", "label": "conclusions", "text": "Short-term use of ferric citrate repletes iron stores , increases hemoglobin levels , and reduces levels of serum phosphate , urinary phosphate excretion , and FGF-@ in patients with chronic kidney disease stages @ to @ .", "sentence_id": 11}
+{"abstract_id": "25499302", "label": "objective", "text": "The aim of this analysis was to assess the @-year long-term safety and effectiveness of a randomized comparison of percutaneous coronary intervention ( PCI ) with sirolimus-eluting stents ( SES ) versus minimally invasive direct coronary artery bypass ( MIDCAB ) surgery for the treatment of isolated proximal left anterior descending lesions .", "sentence_id": 0}
+{"abstract_id": "25499302", "label": "background", "text": "Long-term follow-up data comparing PCI by SES and MIDCAB surgery for isolated proximal left anterior descending lesions are sparse .", "sentence_id": 1}
+{"abstract_id": "25499302", "label": "methods", "text": "Patients were randomized either to PCI with SES ( n = @ ) or MIDCAB ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25499302", "label": "methods", "text": "Follow-up data were obtained after @ years with respect to the primary composite endpoint of death , myocardial infarction , and target vessel revascularization .", "sentence_id": 3}
+{"abstract_id": "25499302", "label": "methods", "text": "Angina was assessed by the Canadian Cardiovascular Society classification and quality of life with Short Form @ and MacNew quality of life questionnaires .", "sentence_id": 4}
+{"abstract_id": "25499302", "label": "results", "text": "Follow-up was conducted in @ patients at a median time of @ years ( interquartile range : @ , @ ) .", "sentence_id": 5}
+{"abstract_id": "25499302", "label": "results", "text": "There were no significant differences in the incidence of the primary composite endpoint between groups ( @ % PCI vs. @ % MIDCAB ; p = @ ) or the endpoints death ( @ % vs. @ % ; p = @ ) and myocardial infarction ( @ % vs. @ % , p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25499302", "label": "results", "text": "However , the target vessel revascularization rate was higher in the PCI group ( @ % vs. @ % ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25499302", "label": "results", "text": "Clinical symptoms and quality of life improved significantly from baseline with both interventions and were similar in magnitude between groups .", "sentence_id": 8}
+{"abstract_id": "25499302", "label": "conclusions", "text": "At @-year follow-up , PCI by SES and MIDCAB in isolated proximal left anterior descending lesions yielded similar long-term outcomes regarding the primary composite clinical endpoint and quality of life .", "sentence_id": 9}
+{"abstract_id": "25499302", "label": "conclusions", "text": "Target vessel revascularization was more frequent in the PCI group .", "sentence_id": 10}
+{"abstract_id": "25499302", "label": "conclusions", "text": "( MIDCAB Versus DES in Proximal LAD Lesions ; NCT@ ) .", "sentence_id": 11}
+{"abstract_id": "25193431", "label": "objective", "text": "This @-arm , phase @ , crossover study compared the relative bioavailability of two dovitinib ( TKI@ ) capsule formulations -LSB- anhydrate clinical service form ( CSF ) and monohydrate final market image ( FMI ) ; Arm @ -RSB- and determined the effect of food on dovitinib exposure ( Arm @ ) .", "sentence_id": 0}
+{"abstract_id": "25193431", "label": "methods", "text": "Patients with advanced solid tumors were enrolled in one of the @ arms .", "sentence_id": 1}
+{"abstract_id": "25193431", "label": "methods", "text": "Arm @ randomized patients to a single @-mg dose of either CSF or FMI followed by @ days of rest and @ mg of the other formulation .", "sentence_id": 2}
+{"abstract_id": "25193431", "label": "methods", "text": "Arm @ patients received @ mg of FMI once daily and were randomized to follow one of six meal sequences , each with three prandial conditions : low fat ( LF ) , high fat ( HF ) , or no meal ( NM ) .", "sentence_id": 3}
+{"abstract_id": "25193431", "label": "results", "text": "Twenty-three and @ patients were enrolled and @ and @ were evaluable in Arms @ and @ , respectively .", "sentence_id": 4}
+{"abstract_id": "25193431", "label": "results", "text": "In Arm @ , the adjusted geometric means for FMI had small reductions relative to CSF -LSB- area under the plasma concentration-time curve ( AUClast ) decreased by @ % , maximum concentration ( C max ) decreased by @ % -RSB- .", "sentence_id": 5}
+{"abstract_id": "25193431", "label": "results", "text": "In Arm @ , the HF meal versus NM showed a @ % increase in the adjusted geometric mean for AUClast and a @ % decrease for C max .", "sentence_id": 6}
+{"abstract_id": "25193431", "label": "results", "text": "The LF meal versus NM comparison showed @ and @ % increases for AUClast and C max , respectively .", "sentence_id": 7}
+{"abstract_id": "25193431", "label": "results", "text": "Overall , common adverse events included nausea , vomiting , diarrhea , and fatigue .", "sentence_id": 8}
+{"abstract_id": "25193431", "label": "conclusions", "text": "Systemic exposure to dovitinib was similar for the FMI and CSF capsule formulations .", "sentence_id": 9}
+{"abstract_id": "25193431", "label": "conclusions", "text": "Additionally , since prandial conditions did not affect the systemic exposure , dovitinib can be taken with or without food .", "sentence_id": 10}
+{"abstract_id": "25163819", "label": "objective", "text": "To determine whether @ alpha-hydroxyprogesterone caproate ( @OHPC ) prolongs gestation beyond @ weeks of gestation ( primary outcome ) and reduces neonatal morbidity ( secondary outcome ) in twin pregnancy .", "sentence_id": 0}
+{"abstract_id": "25163819", "label": "methods", "text": "Randomised controlled double-blind clinical trial .", "sentence_id": 1}
+{"abstract_id": "25163819", "label": "methods", "text": "Tertiary-care university medical centre .", "sentence_id": 2}
+{"abstract_id": "25163819", "label": "methods", "text": "Unselected women with twin pregnancies .", "sentence_id": 3}
+{"abstract_id": "25163819", "label": "methods", "text": "Participants received weekly injections of @ mg @OHPC ( n = @ ) or placebo ( n = @ ) , from @-@ to @ weeks of gestation .", "sentence_id": 4}
+{"abstract_id": "25163819", "label": "methods", "text": "Randomisation was performed using the permuted-block randomisation method .", "sentence_id": 5}
+{"abstract_id": "25163819", "label": "methods", "text": "Data were analysed on an intention-to-treat basis .", "sentence_id": 6}
+{"abstract_id": "25163819", "label": "methods", "text": "Preterm birth ( PTB ) rate before @ weeks of gestation .", "sentence_id": 7}
+{"abstract_id": "25163819", "label": "results", "text": "There were no significant differences in the average gestational age at delivery , or in the rates of PTB before @ , @ , and @ weeks of gestation , between the two groups .", "sentence_id": 8}
+{"abstract_id": "25163819", "label": "results", "text": "The proportion of very-low-birthweight neonates ( < @ g ) was significantly lower in the @OHPC group ( @ % ) compared with placebo ( @ % ) ( relative risk , RR @ ; @ % confidence interval , @ % CI @-@ @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25163819", "label": "results", "text": "Progestogen-treated neonates had a significantly lower composite neonatal morbidity ( @ % ) compared with placebo ( @ % ) ( odds ratio , OR @ ; @ % CI @-@ @ ; P = @ ) , with significantly lower odds for respiratory distress syndrome ( @ versus @ % ; OR @ ; @ % CI @-@ @ ; P = @ ) , retinopathy of prematurity ( @ versus @ % ; OR @ ; @ % CI @-@ @ ; P = @ ) , and culture-confirmed sepsis ( @ versus @ % ; OR @ ; @ % CI @-@ @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25163819", "label": "conclusions", "text": "Intramuscular @OHPC therapy did not reduce PTB before @ weeks of gestation in unselected twin pregnancies .", "sentence_id": 11}
+{"abstract_id": "25163819", "label": "conclusions", "text": "Nonetheless , @OHPC significantly reduced neonatal morbidity parameters and increased birthweight .", "sentence_id": 12}
+{"abstract_id": "24612148", "label": "objective", "text": "To assess treatment satisfaction with tadalafil or tamsulosin vs placebo in a @-week , randomised , double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia ( LUTS/BPH ) .", "sentence_id": 0}
+{"abstract_id": "24612148", "label": "methods", "text": "After a @-week placebo lead-in period , men aged @ years with an International Prostate Symptom Score ( IPSS ) of @ and a maximum urinary flow rate of @ to @mL/s received placebo ( @ men ) , tadalafil @mg ( @ ) , or tamsulosin @ mg ( @ ) once daily for @ weeks .", "sentence_id": 1}
+{"abstract_id": "24612148", "label": "methods", "text": "Treatment Satisfaction Scale-BPH ( TSS-BPH ) responses were assessed based on median treatment differences using the van Elteren test .", "sentence_id": 2}
+{"abstract_id": "24612148", "label": "results", "text": "Overall treatment satisfaction was greater for tadalafil vs placebo ( P = @ ) , based on greater satisfaction with efficacy ( P = @ ) ; neither overall treatment satisfaction nor satisfaction with efficacy was greater for tamsulosin vs placebo ( P @ ) .", "sentence_id": 3}
+{"abstract_id": "24612148", "label": "results", "text": "For individual questions , @ % of men rated tadalafil treatment as ` effective/very effective ' ( Question @ , Q@ ) vs placebo ( P = @ ) , @ % would ` definitely/probably recommend their treatment ' ( Q@ ; P = @ ) , @ % were generally ` very satisfied/satisfied with their medication ' ( Q@ ; P < @ ) , and @ % would ` definitely/probably continue therapy ' ( Q@ ; P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24612148", "label": "results", "text": "With tamsulosin , differences vs placebo were not statistically significant .", "sentence_id": 5}
+{"abstract_id": "24612148", "label": "results", "text": "Subgroup analyses of overall TSS-BPH by baseline age ( @ / > @ years ) , history of erectile dysfunction ( yes/no ) , LUTS/BPH severity ( IPSS < / @ ) , total testosterone level ( < @/@ng/dL ) , and age-specific predicted prostate volume ( < @/@mL ) showed no statistically significant treatment-subgroup interactions .", "sentence_id": 6}
+{"abstract_id": "24612148", "label": "results", "text": "Men with recent prior - blocker therapy reported greater treatment satisfaction with tadalafil vs placebo , with only borderline difference for men without prior therapy .", "sentence_id": 7}
+{"abstract_id": "24612148", "label": "conclusions", "text": "Treatment satisfaction was greater with tadalafil vs placebo , with no significant difference between tamsulosin and placebo .", "sentence_id": 8}
+{"abstract_id": "25322754", "label": "background", "text": "The potential negative influence of angiogenic gene therapy on the development or progression of retinal pathologies such as diabetic retinopathy ( DR ) or age-related macular degeneration ( AMD ) has led to the systematic exclusion of affected patients from trials .", "sentence_id": 0}
+{"abstract_id": "25322754", "label": "background", "text": "We investigated the role of nonviral fibroblast factor @ ( NV@FGF ) in two phase II , multinational , double-blind , randomized , placebo-controlled , gene therapy trials ( TALISMAN @ and @ ) .", "sentence_id": 1}
+{"abstract_id": "25322754", "label": "methods", "text": "One hundred and fifty-two subjects with critical limb ischemia or claudication were randomized to receive eight intramuscular injections of @ ml of NV@FGF at @ mg/ml or @ mg/dl or placebo .", "sentence_id": 2}
+{"abstract_id": "25322754", "label": "methods", "text": "One hundred and fifty-two patients received a plasmid dose of NV@FGF of up to @ mg or placebo .", "sentence_id": 3}
+{"abstract_id": "25322754", "label": "methods", "text": "All patients underwent a systematic ophthalmologic examination at baseline and at @ , @ or @ months following gene therapy .", "sentence_id": 4}
+{"abstract_id": "25322754", "label": "methods", "text": "Twenty-six of these patients ( Mnster subgroup ) received a retinal fluorescence angiography at baseline and at final examination .", "sentence_id": 5}
+{"abstract_id": "25322754", "label": "results", "text": "Among those @ patients , four of nine patients with diabetes suffered from nonproliferative DR. Three patients showed non-exsudative AMD .", "sentence_id": 6}
+{"abstract_id": "25322754", "label": "results", "text": "No change of retinal morphology or function was observed in Mnster subgroup of both TALISMAN trials independent of the intramuscular NV@FGF dosage applied .", "sentence_id": 7}
+{"abstract_id": "25322754", "label": "conclusions", "text": "Angiogenic gene therapy using NV@FGF is safe even in diabetics .", "sentence_id": 8}
+{"abstract_id": "24311384", "label": "objective", "text": "We used the Western Denmark Heart Registry to assess one-year and long-term all-cause mortality and stent failure following Percutaneous Coronary Intervention ( PCI ) with drug-eluting stents ( DES ) or bare-metal stents ( BMS ) .", "sentence_id": 0}
+{"abstract_id": "24311384", "label": "background", "text": "The use of DES compared with BMS during PCI has reduced the risk of restenosis in native coronary artery lesions .", "sentence_id": 1}
+{"abstract_id": "24311384", "label": "background", "text": "In saphenous vein grafts ( SVG ) the outcome after DES compared with BMS is insufficiently described .", "sentence_id": 2}
+{"abstract_id": "24311384", "label": "methods", "text": "From January @ , @ to December @ , @ all patients with PCI of SVG lesions were identified among @ million inhabitants .", "sentence_id": 3}
+{"abstract_id": "24311384", "label": "methods", "text": "Stent failure was defined as clinically driven target lesion revascularization , graft occlusion without intervention , or stent thrombosis .", "sentence_id": 4}
+{"abstract_id": "24311384", "label": "results", "text": "The study cohort consisted of @ patients with @ SVG lesions ( @ DES patients with @ lesions and @ BMS patients with @ lesions ) .", "sentence_id": 5}
+{"abstract_id": "24311384", "label": "results", "text": "Mean age did not differ between patients with DES-treated lesions compared to patients with BMS-treated lesions ( @ @ years vs. @ @ years ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24311384", "label": "results", "text": "The median follow-up time was @ years ( @th-@th percentile : @-@ @ years ) .", "sentence_id": 7}
+{"abstract_id": "24311384", "label": "results", "text": "One-year ( n = @ ( @ % ) vs. n = @ ( @ % ) , log rank P = @ ) and @-year cumulative mortality ( n = @ ( @ % ) vs. n = @ ( @ % ) , log rank P = @ ) did not differ significantly between DES - and BMS-treated patients .", "sentence_id": 8}
+{"abstract_id": "24311384", "label": "results", "text": "One-year cumulative stent failure was seen in @ ( @ % ) DES-treated lesions vs. @ ( @ % ) BMS-treated lesions ( P = @ ) , and @-year cumulative stent failure in @ ( @ % ) vs. @ ( @ % ) lesions ( P = @ ) , respectively .", "sentence_id": 9}
+{"abstract_id": "24311384", "label": "conclusions", "text": "In SVG lesions , DES showed no long-term benefit compared to BMS in rates of all-cause mortality or stent failure .", "sentence_id": 10}
+{"abstract_id": "25312998", "label": "background", "text": "Implementing optimal lung cancer screening programs requires knowledge of the natural history and detectability of lung cancer .", "sentence_id": 0}
+{"abstract_id": "25312998", "label": "background", "text": "This information can be derived from the results of clinical trials with the aid of microsimulation models .", "sentence_id": 1}
+{"abstract_id": "25312998", "label": "methods", "text": "Data from the Surveillance , Epidemiology , and End Results ( SEER ) program and individual-level data from the National Lung Screening Trial ( NLST ) and the Prostate , Lung , Colon , and Ovarian Cancer Screening trial ( PLCO ) were used to investigate the sensitivity ( by histology and stage ) of CT and chest radiography ( CXR ) and the mean preclinical sojourn time ( MPST ) of lung cancer ( by gender , histology , and stage ) .", "sentence_id": 2}
+{"abstract_id": "25312998", "label": "methods", "text": "The MISCAN-Lung model was used to reproduce the lung cancer incidence by method of detection ( clinically or screen-detected ) , gender , histology , and stage in both trials and SEER , by calibrating CT and CXR sensitivity and natural history parameters .", "sentence_id": 3}
+{"abstract_id": "25312998", "label": "results", "text": "CT sensitivity ranges from @ % to @ % and CXR sensitivity from @ % to @ % , depending on histology and stage .", "sentence_id": 4}
+{"abstract_id": "25312998", "label": "results", "text": "CT sensitivity for stage IA is more than @-fold higher compared with CXR , for all histologies .", "sentence_id": 5}
+{"abstract_id": "25312998", "label": "results", "text": "The total MPST estimates for lung cancer progressing through preclinical stages IA to IV range from @ to @ years for men and @ to @ years for women .", "sentence_id": 6}
+{"abstract_id": "25312998", "label": "results", "text": "The largest difference in total MPST between genders was estimated for adenocarcinoma .", "sentence_id": 7}
+{"abstract_id": "25312998", "label": "conclusions", "text": "We estimate longer MPSTs for lung cancer compared with previous research , suggesting a greater window of opportunity for lung cancer screening .", "sentence_id": 8}
+{"abstract_id": "25312998", "label": "conclusions", "text": "This study provides detailed insights into the natural history of lung cancer and CT screening effectiveness .", "sentence_id": 9}
+{"abstract_id": "25629741", "label": "background", "text": "Ruxolitinib , a Janus kinase ( JAK ) @ and @ inhibitor , was shown to have a clinical benefit in patients with polycythemia vera in a phase @ study .", "sentence_id": 0}
+{"abstract_id": "25629741", "label": "background", "text": "We conducted a phase @ open-label study to evaluate the efficacy and safety of ruxolitinib versus standard therapy in patients with polycythemia vera who had an inadequate response to or had unacceptable side effects from hydroxyurea .", "sentence_id": 1}
+{"abstract_id": "25629741", "label": "methods", "text": "We randomly assigned phlebotomy-dependent patients with splenomegaly , in a @:@ ratio , to receive ruxolitinib ( @ patients ) or standard therapy ( @ patients ) .", "sentence_id": 2}
+{"abstract_id": "25629741", "label": "methods", "text": "The primary end point was both hematocrit control through week @ and at least a @ % reduction in spleen volume at week @ , as assessed by means of imaging .", "sentence_id": 3}
+{"abstract_id": "25629741", "label": "results", "text": "The primary end point was achieved in @ % of the patients in the ruxolitinib group versus @ % of those in the standard-therapy group ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25629741", "label": "results", "text": "Hematocrit control was achieved in @ % of patients receiving ruxolitinib and @ % of those receiving standard therapy ; @ % and @ % of patients in the two groups , respectively , had at least a @ % reduction in spleen volume .", "sentence_id": 5}
+{"abstract_id": "25629741", "label": "results", "text": "A complete hematologic remission was achieved in @ % of patients in the ruxolitinib group and @ % of those in the standard-therapy group ( P = @ ) ; @ % versus @ % had at least a @ % reduction in the total symptom score at week @ .", "sentence_id": 6}
+{"abstract_id": "25629741", "label": "results", "text": "In the ruxolitinib group , grade @ or @ anemia occurred in @ % of patients , and grade @ or @ thrombocytopenia occurred in @ % ; the corresponding percentages in the standard-therapy group were @ % and @ % .", "sentence_id": 7}
+{"abstract_id": "25629741", "label": "results", "text": "Herpes zoster infection was reported in @ % of patients in the ruxolitinib group and @ % of those in the standard-therapy group ( grade @ or @ in all cases ) .", "sentence_id": 8}
+{"abstract_id": "25629741", "label": "results", "text": "Thromboembolic events occurred in one patient receiving ruxolitinib and in six patients receiving standard therapy .", "sentence_id": 9}
+{"abstract_id": "25629741", "label": "conclusions", "text": "In patients who had an inadequate response to or had unacceptable side effects from hydroxyurea , ruxolitinib was superior to standard therapy in controlling the hematocrit , reducing the spleen volume , and improving symptoms associated with polycythemia vera .", "sentence_id": 10}
+{"abstract_id": "25629741", "label": "conclusions", "text": "( Funded by Incyte and others ; RESPONSE ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24324379", "label": "background", "text": "This pilot study investigated the efficacy of a novel virtual reality-cognitive rehabilitation ( VR-CR ) intervention to improve contextual processing of objects in children with autism .", "sentence_id": 0}
+{"abstract_id": "24324379", "label": "background", "text": "Previous research supports that children with autism show deficits in contextual processing , as well as deficits in its elementary components : abstraction and cognitive flexibility .", "sentence_id": 1}
+{"abstract_id": "24324379", "label": "methods", "text": "Four children with autism participated in a multiple-baseline , single-subject study .", "sentence_id": 2}
+{"abstract_id": "24324379", "label": "methods", "text": "The children were taught how to see objects in context by reinforcing attention to pivotal contextual information .", "sentence_id": 3}
+{"abstract_id": "24324379", "label": "results", "text": "All children demonstrated statistically significant improvements in contextual processing and cognitive flexibility .", "sentence_id": 4}
+{"abstract_id": "24324379", "label": "results", "text": "Mixed results were found on the control test and changes in context-related behaviours .", "sentence_id": 5}
+{"abstract_id": "24324379", "label": "conclusions", "text": "Larger-scale studies are warranted to determine the effectiveness and usability in comprehensive educational programs .", "sentence_id": 6}
+{"abstract_id": "25921382", "label": "background", "text": "During the ACCORD @ randomized trial , an evaluation of the clinical tumor response was prospectively performed after neoadjuvant chemoradiotherapy .", "sentence_id": 0}
+{"abstract_id": "25921382", "label": "background", "text": "The correlations between clinical complete response and patient characteristics and treatment outcomes are reported .", "sentence_id": 1}
+{"abstract_id": "25921382", "label": "methods", "text": "Between @ and @ the Accord @ trial accrued @ patients with locally advanced rectal cancer and compared two different neoadjuvant chemoradiotherapies ( Capox @ : capecitabine + oxaliplatin +@ Gy vs Cap @ : capecitabine +@ Gy ) .", "sentence_id": 2}
+{"abstract_id": "25921382", "label": "methods", "text": "An evaluation of the clinical tumor response with rectoscopy and digital rectal examination was planned before surgery .", "sentence_id": 3}
+{"abstract_id": "25921382", "label": "methods", "text": "A score to classify tumor response was used adapted from the RECIST definition : complete response : no visible or palpable tumor ; partial response , stable and progressive disease .", "sentence_id": 4}
+{"abstract_id": "25921382", "label": "results", "text": "The clinical tumor response was evaluable in @ patients .", "sentence_id": 5}
+{"abstract_id": "25921382", "label": "results", "text": "Score was : complete response : @ % ( @ patients ) ; partial response : @ % ( @ patients ) ; stable : @ % ; progression : @ % .", "sentence_id": 6}
+{"abstract_id": "25921382", "label": "results", "text": "There was a trend toward more complete response in the Capox @ group ( @ % vs @ % with Cap @ ) .", "sentence_id": 7}
+{"abstract_id": "25921382", "label": "results", "text": "In the whole cohort of @ pts complete response was significantly more frequent in T@ tumors ( @ % ; p = @ ) ; tumors < @cm in diameter ( @ % ; p = @ ) , less than half rectal circumference and with a normal CEA level .", "sentence_id": 8}
+{"abstract_id": "25921382", "label": "results", "text": "Clinical complete response observed in @ patients was associated with more conservative treatment ( p = @ ) : @ patients required an abdomino-perineal resection , @ an anterior resection and @ patients benefited from organ preservation ( @ local excision , @ `` watch and wait '' .", "sentence_id": 9}
+{"abstract_id": "25921382", "label": "results", "text": "A complete response was associated with more ypT@ ( @ % ; p < @ ) ; ypNO ( @ % ) ; R@ circumferential margin ( @ % ) .", "sentence_id": 10}
+{"abstract_id": "25921382", "label": "conclusions", "text": "These data support the hypothesis that a clinical complete response assessed using rectoscopy and digital rectal examination after neoadjuvant therapy may increase the chance of a sphincter or organ preservation in selected rectal cancers .", "sentence_id": 11}
+{"abstract_id": "24451151", "label": "background", "text": "New direct-acting antiviral agents are currently being developed to treat chronic HCV .", "sentence_id": 0}
+{"abstract_id": "24451151", "label": "background", "text": "The efficacy and safety of daclatasvir combined with peginterferon alfa-@a ( alfa-@a ) and ribavirin were assessed in a randomized , double-blind Phase IIa study of Japanese patients with chronic HCV genotype-@ infection .", "sentence_id": 1}
+{"abstract_id": "24451151", "label": "methods", "text": "Japanese patients who were treatment-naive ( n = @ ) or prior null ( n = @ ) or partial ( n = @ ) responders received once-daily daclatasvir @ mg or @ mg or placebo in combination with alfa-@a and ribavirin .", "sentence_id": 2}
+{"abstract_id": "24451151", "label": "methods", "text": "Daclatasvir recipients with a protocol-defined response ( HCV RNA < @ IU/ml at week @ and undetectable at week @ ) were treated for @ weeks ; placebo recipients and patients without a protocol-defined response were treated for @ weeks .", "sentence_id": 3}
+{"abstract_id": "24451151", "label": "results", "text": "Sustained virological response at @ weeks post-treatment ( SVR@ ) was achieved by @ % and @ % of treatment-naive patients receiving daclatasvir @ mg and @ mg , respectively , versus @ % in placebo recipients .", "sentence_id": 4}
+{"abstract_id": "24451151", "label": "results", "text": "Virological failure was more frequent in prior non-responder patients , with @ % and @ % achieving SVR@ in daclatasvir @ mg and @ mg groups , respectively .", "sentence_id": 5}
+{"abstract_id": "24451151", "label": "results", "text": "Adverse events occurred with similar frequency among treatment groups and were consistent with the adverse event profile of alfa-@a / ribavirin alone .", "sentence_id": 6}
+{"abstract_id": "24451151", "label": "results", "text": "The most commonly reported adverse events included pyrexia , alopecia , anaemia , lymphopenia , neutropenia , pruritus and diarrhoea .", "sentence_id": 7}
+{"abstract_id": "24451151", "label": "results", "text": "Three patients discontinued treatment due to anaemia .", "sentence_id": 8}
+{"abstract_id": "24451151", "label": "conclusions", "text": "Daclatasvir combined with alfa-@a / ribavirin in treatment-naive patients showed greater efficacy than alfa-@a / ribavirin alone and was generally well tolerated .", "sentence_id": 9}
+{"abstract_id": "24451151", "label": "conclusions", "text": "The @-mg dose of daclatasvir achieved the highest rates of SVR@ in both treatment-naive and non-responder populations and will be evaluated in a Phase III clinical trial .", "sentence_id": 10}
+{"abstract_id": "24700991", "label": "objective", "text": "To investigate the effect of abstention from breastfeeding , for an hour before and after each vaccination , on the immune responses of infants to two doses of rotavirus vaccine .", "sentence_id": 0}
+{"abstract_id": "24700991", "label": "methods", "text": "In Soweto , South Africa , mother-infant pairs who were uninfected with human immunodeficiency virus ( HIV ) were enrolled as they presented for the `` @-week '' immunizations of the infants .", "sentence_id": 1}
+{"abstract_id": "24700991", "label": "methods", "text": "Each infant was randomly assigned to Group @ - in which breastfeeding was deferred for at least @ h before and after each dose of rotavirus vaccine - or Group @ - in which unrestricted breastfeeding was encouraged .", "sentence_id": 2}
+{"abstract_id": "24700991", "label": "methods", "text": "Enzyme-linked immunosorbent assays were used to evaluate the titres of rotavirus-specific IgA in samples of serum collected from each infant immediately before each vaccine dose and @ month after the second dose .", "sentence_id": 3}
+{"abstract_id": "24700991", "label": "methods", "text": "Among the infants , a fourfold or greater increase in titres of rotavirus-specific IgA following vaccination was considered indicative of seroconversion .", "sentence_id": 4}
+{"abstract_id": "24700991", "label": "results", "text": "The evaluable infants in Group @ ( n = @ ) were similar to those in Group @ ( n = @ ) in their baseline demographic characteristics and their pre-vaccination titres of anti-rotavirus IgA .", "sentence_id": 5}
+{"abstract_id": "24700991", "label": "results", "text": "After the second vaccine doses , geometric mean titres of anti-rotavirus IgA in the sera of Group-@ infants were similar to those in the sera of Group-@ infants ( P = @ ) and the frequency of seroconversion in the Group-@ infants was similar to that in the Group-@ infants ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24700991", "label": "conclusions", "text": "Among HIV-uninfected South African infants , abstention from breastfeeding for at least @ h before and after each vaccination dose had no significant effect on the infants ' immune response to a rotavirus vaccine .", "sentence_id": 7}
+{"abstract_id": "26077235", "label": "objective", "text": "To determine long-term outcomes in a clinical trial evaluating the role of taxane type and schedule in operable breast cancer and evaluate the impact of obesity and black race on outcome .", "sentence_id": 0}
+{"abstract_id": "26077235", "label": "methods", "text": "A total of @,@ eligible women with stage II to III breast cancer treated with four cycles of doxorubicin plus cyclophosphamide were randomly assigned to receive paclitaxel or docetaxel every @ weeks for four doses or weekly for @ doses using a @ @ factorial design .", "sentence_id": 1}
+{"abstract_id": "26077235", "label": "methods", "text": "The primary end point was disease-free survival ( DFS ) .", "sentence_id": 2}
+{"abstract_id": "26077235", "label": "methods", "text": "Results are expressed as hazard ratios ( HRs ) from Cox proportional hazards models .", "sentence_id": 3}
+{"abstract_id": "26077235", "label": "methods", "text": "All P values are two sided .", "sentence_id": 4}
+{"abstract_id": "26077235", "label": "results", "text": "When compared with the standard every-@-week paclitaxel arm , after a median follow-up of @ years , DFS significantly improved and overall survival ( OS ) marginally improved only for the weekly paclitaxel ( HR , @ ; P = @ and HR , @ ; P = @ , respectively ) and every-@-week docetaxel arms ( HR , @ ; P = @ and HR , @ ; P = @ , respectively ) .", "sentence_id": 5}
+{"abstract_id": "26077235", "label": "results", "text": "Weekly paclitaxel improved DFS and OS ( HR , @ ; P = @ and HR , @ ; P = @ , respectively ) in triple-negative breast cancer .", "sentence_id": 6}
+{"abstract_id": "26077235", "label": "results", "text": "For hormone receptor-positive , human epidermal growth factor receptor @-nonoverexpressing disease , no experimental arm improved OS , and black race and obesity were associated with increased risk of breast cancer recurrence and death .", "sentence_id": 7}
+{"abstract_id": "26077235", "label": "conclusions", "text": "Improved outcomes initially observed for weekly paclitaxel were qualitatively similar but quantitatively less pronounced with longer follow-up , although exploratory analysis suggested substantial benefit in triple-negative disease .", "sentence_id": 8}
+{"abstract_id": "26077235", "label": "conclusions", "text": "Further research is required to understand why obesity and race influence clinical outcome in hormone receptor-positive disease .", "sentence_id": 9}
+{"abstract_id": "25583753", "label": "objective", "text": "Immune intervention trials in recent-onset type @ diabetes would benefit from biomarkers associated with good therapeutic response .", "sentence_id": 0}
+{"abstract_id": "25583753", "label": "objective", "text": "In the previously reported randomized placebo-controlled anti-CD@ study ( otelixizumab ; GlaxoSmithKline ) , we tested the hypothesis that specific diabetes autoantibodies might serve this purpose .", "sentence_id": 1}
+{"abstract_id": "25583753", "label": "methods", "text": "In the included patients ( n = @ otelixizumab , n = @ placebo ) , - cell function was assessed as area under the curve ( AUC ) C-peptide release during a hyperglycemic glucose clamp at baseline ( median duration of insulin treatment : @ days ) and every @ months until @ months after randomization .", "sentence_id": 2}
+{"abstract_id": "25583753", "label": "methods", "text": "( Auto ) antibodies against insulin ( I -LSB- A -RSB- A ) , GAD ( GADA ) , IA-@ ( IA-@A ) , and ZnT@ ( ZnT@A ) were determined on stored sera by liquid-phase radiobinding assay .", "sentence_id": 3}
+{"abstract_id": "25583753", "label": "results", "text": "At baseline , only better preserved AUC C-peptide release and higher levels of IAA were associated with better preservation of - cell function and lower insulin needs under anti-CD@ treatment .", "sentence_id": 4}
+{"abstract_id": "25583753", "label": "results", "text": "In multivariate analysis , IAA ( P = @ ) or the interaction of IAA and C-peptide ( P = @ ) independently predicted outcome together with treatment .", "sentence_id": 5}
+{"abstract_id": "25583753", "label": "results", "text": "During follow-up , good responders to anti-CD@ treatment ( i.e. , IAA ( + ) participants with relatively preserved - cell function -LSB- @ % of healthy control subjects -RSB- ) experienced a less pronounced insulin-induced rise in I ( A ) A and lower insulin needs .", "sentence_id": 6}
+{"abstract_id": "25583753", "label": "results", "text": "GADA , IA-@A , and ZnT@A levels were not influenced by anti-CD@ treatment , and their changes showed no relation to functional outcome .", "sentence_id": 7}
+{"abstract_id": "25583753", "label": "conclusions", "text": "There is important specificity of IAA among other diabetes autoantibodies to predict good therapeutic response of recent-onset type @ diabetic patients to anti-CD@ treatment .", "sentence_id": 8}
+{"abstract_id": "25583753", "label": "conclusions", "text": "If confirmed , future immune intervention trials in type @ diabetes should consider both relatively preserved functional - cell mass and presence of IAA as inclusion criteria .", "sentence_id": 9}
+{"abstract_id": "24745199", "label": "objective", "text": "The aim of this study was to evaluate the efficacy of a @-day accommodation protocol on reducing perceived discomfort while sitting on a stability ball ( SB ) ; trunk muscle activity levels and lumbar spinal postures were also considered .", "sentence_id": 0}
+{"abstract_id": "24745199", "label": "background", "text": "Previous studies have compared SB sitting with office chair sitting with few observed differences in muscle activity or posture ; however , greater discomfort during SB sitting has been reported .", "sentence_id": 1}
+{"abstract_id": "24745199", "label": "background", "text": "These findings may indicate an accommodation period is necessary to acclimate to SB sitting .", "sentence_id": 2}
+{"abstract_id": "24745199", "label": "methods", "text": "For this study , @ males and @ females completed two separate , @-hr sitting sessions on an SB .", "sentence_id": 3}
+{"abstract_id": "24745199", "label": "methods", "text": "Half the participants completed a @-day accommodation period between the visits , whereas the other half did not use an SB during the time .", "sentence_id": 4}
+{"abstract_id": "24745199", "label": "methods", "text": "On both occasions , self-reported perceived discomfort ratings were collected along with erector spinae and abdominal muscle activity and lumbar spinal postures .", "sentence_id": 5}
+{"abstract_id": "24745199", "label": "results", "text": "Discomfort ratings were reduced in female participants following the accommodation ; no effects on muscle activation or lumbar spine postures were observed .", "sentence_id": 6}
+{"abstract_id": "24745199", "label": "conclusions", "text": "Accommodation training may reduce perceived low-back discomfort in females.Trunk muscle activity and lumbar spine postures during seated office work on an SB did not differ between groups ; however , greater sample power was required to conclusively address these variables .", "sentence_id": 7}
+{"abstract_id": "24745199", "label": "conclusions", "text": "Regarding whether to use an SB in place of a standard office chair , this study indicates that females electing to use an SB can decrease discomfort by following an accommodation protocol ; no evidence was found to indicate that SB chair use will improve trunk strength or posture , even following an accommodation period .", "sentence_id": 8}
+{"abstract_id": "24274323", "label": "background", "text": "Dietary fiber ( DF ) intake in American children is suboptimal , increasing the risk of GI distress and contributing to poor diet quality .", "sentence_id": 0}
+{"abstract_id": "24274323", "label": "background", "text": "The objective of this study was to determine the effect of introducing two high-fiber snacks per day on gastrointestinal function as well as nutrient and food group intake in healthy children ages @-@years old .", "sentence_id": 1}
+{"abstract_id": "24274323", "label": "methods", "text": "This study was a randomized controlled prospective intervention study of children @-@years of age ( n = @ ) attending a rural Midwestern elementary school .", "sentence_id": 2}
+{"abstract_id": "24274323", "label": "methods", "text": "Children were randomized by classroom to consume two high-fiber snacks per day ( total of @-@g DF ) or their usual snacks for @weeks .", "sentence_id": 3}
+{"abstract_id": "24274323", "label": "methods", "text": "Participants completed two @-hour dietary recalls and a questionnaire about their GI health at baseline , mid-intervention ( week @ ) , and post-intervention .", "sentence_id": 4}
+{"abstract_id": "24274323", "label": "methods", "text": "Dietary data was entered into NDSR @ and t-tests utilized to assess changes .", "sentence_id": 5}
+{"abstract_id": "24274323", "label": "methods", "text": "Analyses were completed in SAS @ .", "sentence_id": 6}
+{"abstract_id": "24274323", "label": "results", "text": "Children consumed at least half their snack @ % of the time when a snack was chosen ( @ % of time ) .", "sentence_id": 7}
+{"abstract_id": "24274323", "label": "results", "text": "Participants in both the intervention and control group had healthy scores on the GI health questionnaire at all time points .", "sentence_id": 8}
+{"abstract_id": "24274323", "label": "results", "text": "The intervention group increased DF ( P = @ ) and whole grain ( WG ) intake ( P = @ ) at mid-intervention but after the intervention returned to their baseline DF intake ( P = @ ) and decreased their WG intake ( P = @ ) compared to baseline .", "sentence_id": 9}
+{"abstract_id": "24274323", "label": "results", "text": "Eating high-fiber snacks increased DF intake by @ g per day ( @ % increase ) , suggesting displacement of other fiber-rich foods .", "sentence_id": 10}
+{"abstract_id": "24274323", "label": "conclusions", "text": "Study results indicate that children accept high-fiber foods , thus making these high-fiber foods and snacks consistently available will increase DF intake .", "sentence_id": 11}
+{"abstract_id": "24686347", "label": "objective", "text": "With the safety of laparoscopic cholecystectomy ( LC ) having been established , the current stress is on reducing the postoperative morbidity associated with this procedure .", "sentence_id": 0}
+{"abstract_id": "24686347", "label": "objective", "text": "Hence , this study was undertaken to compare the effect of low-pressure ( @ mm Hg ) ( LPLC ) versus standard-pressure ( @ mm Hg ) ( SPLC ) pneumoperitoneum on postoperative pain , respiratory and liver functions , the stress response , and the intraoperative surgeon comfort in patients undergoing LC .", "sentence_id": 1}
+{"abstract_id": "24686347", "label": "methods", "text": "Patients undergoing LC ( n = @ ) were randomized into the LPLC ( @ mm Hg ) group ( n = @ ) and the SPLC ( @ mm Hg ) group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24686347", "label": "methods", "text": "Postoperative pain , changes in liver function , peak expiration flow rate , C-reactive protein level , and intraoperative surgeon comfort were assessed .", "sentence_id": 3}
+{"abstract_id": "24686347", "label": "results", "text": "The postoperative pain scores ( P = @ , @ , @ , and @ at @ , @ , @ , and @ h ) , total analgesic requirement ( P = @ ) , and the number ( total and good ) of demands for analgesic in the first @ hours ( P = @ and @ ) were lower in the LPLC group .", "sentence_id": 4}
+{"abstract_id": "24686347", "label": "results", "text": "The surgeon comfort in the LPLC group was significantly lesser ( P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24686347", "label": "results", "text": "The liver function and peak expiration flow rate did not show any significant changes .", "sentence_id": 6}
+{"abstract_id": "24686347", "label": "results", "text": "C-reactive protein levels varied significantly only at @ hours postoperatively ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24686347", "label": "conclusions", "text": "The use of low-pressure pneumoperitoneum ( @ mm Hg ) for LC is associated with a significantly lower postoperative pain .", "sentence_id": 8}
+{"abstract_id": "24686347", "label": "conclusions", "text": "However , the use of this low-pressure pneumoperitoneum can jeopardize the surgeon 's comfort .", "sentence_id": 9}
+{"abstract_id": "24856872", "label": "background", "text": "The @ KDIGO ( Kidney Disease : Improving Global Outcomes ) chronic kidney disease-mineral and bone disorder clinical practice guideline suggests correcting @-hydroxyvitamin D@ ( @ -LSB- OH -RSB- D ) levels < @ng/mL in patients treated with maintenance hemodialysis , but does not provide a specific treatment protocol .", "sentence_id": 0}
+{"abstract_id": "24856872", "label": "methods", "text": "@-center , double-blind , randomized , @-week , controlled trial followed by a @-week open-label study .", "sentence_id": 1}
+{"abstract_id": "24856872", "label": "methods", "text": "@ adult maintenance hemodialysis patients with @ ( OH ) D levels < @ng/mL were recruited from June @ through October@ .", "sentence_id": 2}
+{"abstract_id": "24856872", "label": "methods", "text": "Cholecalciferol , @,@ IU , per week orally versus placebo for @ weeks , then @ weeks of individualized cholecalciferol prescription based on NKF-KDOQI ( National Kidney Foundation-Kidney Disease Outcomes Quality Initiative ) guidelines .", "sentence_id": 3}
+{"abstract_id": "24856872", "label": "results", "text": "Primary end point was the percentage of patients with @ ( OH ) D levels@ng/mL at @ weeks .", "sentence_id": 4}
+{"abstract_id": "24856872", "label": "results", "text": "Secondary outcomes included the percentage of patients with normal calcium , phosphorus , and intact parathyroidhormone ( iPTH ) blood levels .", "sentence_id": 5}
+{"abstract_id": "24856872", "label": "results", "text": "Safety measures included incidence of hypercalcemia and hypervitaminosis D.", "sentence_id": 6}
+{"abstract_id": "24856872", "label": "methods", "text": "Blood calcium and phosphate were measured weekly ; iPTH , @ ( OH ) D , @,@-dihydroxyvitamin D@ ( @,@ -LSB- OH -RSB- @D ) , and bone turnover markers , trimonthly ; fetuin A and fibroblast growth factor @ ( FGF-@ ) serum levels and aortic calcification scores were determined at weeks @ and@ .", "sentence_id": 7}
+{"abstract_id": "24856872", "label": "results", "text": "The primary end point significantly increased in the treatment group compared with the placebo group ( @ % vs @ % ; P < @ ) , as well as @,@ ( OH ) @D levels ( @ -LSB- IQR , @-@ -RSB- vs @ -LSB- IQR , @-@ -RSB- pg/mL ; P < @ ) and the proportion of patients achieving the target calcium level ( @ % vs @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24856872", "label": "results", "text": "Incidence of hypercalcemia and phosphate and iPTH levels were similar between groups .", "sentence_id": 9}
+{"abstract_id": "24856872", "label": "results", "text": "The second @-week study phase did not significantly modify the prevalence of @ ( OH ) D level@ng/mL in patients issued from the placebo group .", "sentence_id": 10}
+{"abstract_id": "24856872", "label": "conclusions", "text": "Small size of the study population .", "sentence_id": 11}
+{"abstract_id": "24856872", "label": "conclusions", "text": "Oral weekly administration of @,@ IU of cholecalciferol for @ weeks is an effective , safe , inexpensive , and manageable way to increase @ ( OH ) D and @,@ ( OH ) @D levels in hemodialysis patients .", "sentence_id": 12}
+{"abstract_id": "24856872", "label": "conclusions", "text": "Further evaluation of clinical end points is suggested .", "sentence_id": 13}
+{"abstract_id": "24490871", "label": "background", "text": "Physical activity affords a wide range of physiological and psychological benefits for children and adolescents , yet many children with physical disabilities are insufficiently active to achieve these benefits .", "sentence_id": 0}
+{"abstract_id": "24490871", "label": "background", "text": "The StepUp program is a newly developed @-week pedometer-based self-management program for children and adolescents with physical disability .", "sentence_id": 1}
+{"abstract_id": "24490871", "label": "background", "text": "Participants use a pedometer to undertake a @-week physical activity challenge , with personalised daily step count goals set in consultation with a physiotherapist .", "sentence_id": 2}
+{"abstract_id": "24490871", "label": "background", "text": "The study aims to evaluate the effectiveness of the StepUp program , using a randomised control trial design .", "sentence_id": 3}
+{"abstract_id": "24490871", "label": "methods", "text": "A target sample of @ young people with physical disabilities ( aged @-@ years , ambulant with or without aid , residing in Adelaide ) will be recruited .", "sentence_id": 4}
+{"abstract_id": "24490871", "label": "methods", "text": "Participants will be randomly allocated to either intervention or control following completion of baseline assessments .", "sentence_id": 5}
+{"abstract_id": "24490871", "label": "methods", "text": "Assessments are repeated at @ weeks ( immediately post intervention ) and @ weeks ( @ weeks post intervention ) .", "sentence_id": 6}
+{"abstract_id": "24490871", "label": "methods", "text": "The primary outcome is objective physical activity determined from @ day accelerometry , and the secondary outcomes are exercise intention , physical self-worth , quality of life and fatigue .", "sentence_id": 7}
+{"abstract_id": "24490871", "label": "methods", "text": "Analyses will be undertaken on an intention-to-treat basis using random effects mixed modelling .", "sentence_id": 8}
+{"abstract_id": "24490871", "label": "conclusions", "text": "This study will provide information about the potential of a low-touch and low-cost physical activity intervention for children and adolescents with cerebral palsy .", "sentence_id": 9}
+{"abstract_id": "24899241", "label": "objective", "text": "To assess the effect of virtual reality distraction on pain among patients with a hand injury undergoing a dressing change .", "sentence_id": 0}
+{"abstract_id": "24899241", "label": "background", "text": "Virtual reality distraction can effectively alleviate pain among patients undergoing a dressing change .", "sentence_id": 1}
+{"abstract_id": "24899241", "label": "background", "text": "Clinical research has not addressed pain control during a dressing change .", "sentence_id": 2}
+{"abstract_id": "24899241", "label": "methods", "text": "A randomised controlled trial was performed .", "sentence_id": 3}
+{"abstract_id": "24899241", "label": "methods", "text": "In the first dressing change sequence , @ patients were randomly divided into an experimental group and a control group , with @ cases in each group .", "sentence_id": 4}
+{"abstract_id": "24899241", "label": "methods", "text": "Pain levels were compared between the two groups before and after the dressing change using a visual analog scale .", "sentence_id": 5}
+{"abstract_id": "24899241", "label": "methods", "text": "The sense of involvement in virtual environments was measured using the Pearson correlation coefficient analysis , which determined the relationship between the sense of involvement and pain level .", "sentence_id": 6}
+{"abstract_id": "24899241", "label": "results", "text": "The difference in visual analog scale scores between the two groups before the dressing change was not statistically significant ( t = @ , p > @ ) , but the scores became statistically significant after the dressing change ( t = -@ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24899241", "label": "results", "text": "The correlation between the sense of involvement in a virtual environment and pain level during the dressing was statistically significant ( R ( @ ) = @ , p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24899241", "label": "conclusions", "text": "Virtual reality distraction can effectively alleviate pain among patients with a hand injury undergoing a dressing change .", "sentence_id": 9}
+{"abstract_id": "24899241", "label": "conclusions", "text": "Better results can be obtained by increasing the sense of involvement in a virtual environment .", "sentence_id": 10}
+{"abstract_id": "24899241", "label": "conclusions", "text": "Virtual reality distraction can effectively relieve pain without side effects and is not reliant on a doctor 's prescription .", "sentence_id": 11}
+{"abstract_id": "24899241", "label": "conclusions", "text": "This tool is convenient for nurses to use , especially when analgesics are unavailable .", "sentence_id": 12}
+{"abstract_id": "24403824", "label": "objective", "text": "To compare the safety , efficacy , and impact on stent graft positioning between rapid artificial cardiac pacing ( RACP ) , induced hypotension and sodium nitroprusside ( SNP ) induced hypotension during thoracic endovascular aortic repair ( TEVAR ) for Stanford B aortic dissection .", "sentence_id": 0}
+{"abstract_id": "24403824", "label": "methods", "text": "One hundred and sixty-eight patients , who were diagnosed with Stanford B aortic dissection and who underwent selective TEVAR in Guangdong General Hospital and the People 's Hospital of Baoan District , Shenzhen , People 's Republic of China , were enrolled in this study .", "sentence_id": 1}
+{"abstract_id": "24403824", "label": "methods", "text": "Patients were randomly divided into a RACP group ( n = @ ) and a SNP group ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24403824", "label": "methods", "text": "During localization and deployment of the stent graft , hypotension was induced by RACP or intravenous SNP , according to randomization .", "sentence_id": 3}
+{"abstract_id": "24403824", "label": "methods", "text": "Hemodynamics , landing precision ( deviation from planned placement site ) , duration of procedure , renal function , neurocognitive function , and incidence of endoleaks and paraplegia/hemiplegia were compared .", "sentence_id": 4}
+{"abstract_id": "24403824", "label": "methods", "text": "Except for methods of inducing hypotension , TEVAR was performed according to the same protocol in each group .", "sentence_id": 5}
+{"abstract_id": "24403824", "label": "results", "text": "RACP was successfully performed in all patients assigned to the RACP group .", "sentence_id": 6}
+{"abstract_id": "24403824", "label": "results", "text": "Compared with the SNP group , blood pressure was significantly lower ( @ versus @ mmHg , P = @ ) and the restoration time of blood pressure and the operation duration were significantly shorter ( @ versus @ seconds , P < @ ; @ versus @ minutes , P < @ , respectively ) in the RACP group .", "sentence_id": 7}
+{"abstract_id": "24403824", "label": "results", "text": "Stent graft localization/deployment was more precise in the RACP group ( @ versus @ mm , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24403824", "label": "results", "text": "Compared to baseline , there was no significant change after TEVAR in either group in regard to renal function , neurocognitive function , and incidence of endoleaks and paraplegia/hemiplegia .", "sentence_id": 9}
+{"abstract_id": "24403824", "label": "conclusions", "text": "RACP can be safely applied to patients undergoing TEVAR for Stanford B dissection .", "sentence_id": 10}
+{"abstract_id": "24403824", "label": "conclusions", "text": "RACP can shorten the operation duration and facilitate precise graft localization/deployment .", "sentence_id": 11}
+{"abstract_id": "25719937", "label": "objective", "text": "Elevated intraocular pressure ( IOP ) is a well-known adverse event associated with the fluocinolone acetonide implant ( FAI ) , but no data are available regarding factors associated with increased risk of IOP elevation in patients treated with the FAI .", "sentence_id": 0}
+{"abstract_id": "25719937", "label": "objective", "text": "To report risk factors that may predispose patients to elevated IOP after treatment with the FAI .", "sentence_id": 1}
+{"abstract_id": "25719937", "label": "methods", "text": "Data from @ multicenter , @-year , prospective , randomized , phase @b/@ clinical trials evaluating the safety and efficacy of the FAI were pooled and analyzed .", "sentence_id": 2}
+{"abstract_id": "25719937", "label": "methods", "text": "Patients had no underlying glaucoma and at least one eye with a history of recurrent noninfectious uveitis affecting the posterior segment .", "sentence_id": 3}
+{"abstract_id": "25719937", "label": "methods", "text": "Patients were treated with @ or more of the following : systemic therapy ( corticosteroids or other immunosuppressive drugs ) for at least @ months before enrollment , @ or more sub-Tenon capsule corticosteroid injections for uveitis management during the @ months before enrollment , or systemic corticosteroid or sub-Tenon capsule corticosteroid injection therapy required for at least @ separate recurrences within @ months before enrollment .", "sentence_id": 4}
+{"abstract_id": "25719937", "label": "methods", "text": "Factors evaluated as risk factors for IOP elevation included age , sex , lens status , uveitis severity at enrollment , and location of uveitis .", "sentence_id": 5}
+{"abstract_id": "25719937", "label": "results", "text": "Data analyses were based on @ eyes .", "sentence_id": 6}
+{"abstract_id": "25719937", "label": "results", "text": "A total of @ eyes did not receive the FAI , whereas @ eyes had the @-mg FAI placed .", "sentence_id": 7}
+{"abstract_id": "25719937", "label": "results", "text": "An increase in IOP of @ mm Hg or elevation to @ mm Hg was seen in @ untreated eyes ( @ % ) and @ treated eyes ( @ % ) ( hazard ratio , @ ; @ % CI , @-@ @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25719937", "label": "results", "text": "A total of @ untreated eyes ( @ % ) required surgical intervention for elevated IOP compared with @ treated eyes ( @ % ) ( hazard ratio , @ ; @ % CI , @-@ @ ; P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25719937", "label": "results", "text": "In patients with the FAI , younger age , male sex , and phakic lens status were associated with higher risk of IOP elevation and the need for glaucoma surgery ( P = @ , P < @ , and P < @ , respectively ) .", "sentence_id": 10}
+{"abstract_id": "25719937", "label": "conclusions", "text": "Patients receiving the FAI are at higher risk of developing an IOP increase of @ mm Hg or an absolute IOP of @ mm Hg when compared with patients without the FAI .", "sentence_id": 11}
+{"abstract_id": "25719937", "label": "conclusions", "text": "Patients who are male , younger , and phakic are at an even higher risk for elevated IOP and possibly glaucoma surgery .", "sentence_id": 12}
+{"abstract_id": "24881853", "label": "background", "text": "Liver abscess is a rare but potentially fatal complication of transarterial chemoembolization .", "sentence_id": 0}
+{"abstract_id": "24881853", "label": "background", "text": "Other than for biliary abnormalities , risk factors for liver abscess formation after transarterial chemoembolization have rarely been discussed .", "sentence_id": 1}
+{"abstract_id": "24881853", "label": "objective", "text": "To identify other risk factors of liver abscess after transarterial chemoembolization in patients with hepatocellular carcinoma .", "sentence_id": 2}
+{"abstract_id": "24881853", "label": "methods", "text": "Data for @ patients with hepatocellular carcinoma who underwent transarterial chemoembolization from July @ to December @ were retrospectively reviewed .", "sentence_id": 3}
+{"abstract_id": "24881853", "label": "methods", "text": "@ patients who experienced liver abscess after transarterial chemoembolization were enrolled as a case group , which was compared with a randomly selected control group ( n = @ ) of patients who did not develop liver abscess after transarterial chemoembolization .", "sentence_id": 4}
+{"abstract_id": "24881853", "label": "results", "text": "Pneumobilia , type @ biliary abnormality , type @ biliary abnormality , diabetes mellitus , tumour number ( @ ) , tumour size ( @cm ) , and tumour necrosis on the pre-transarterial chemoembolization computed tomography , and gelfoam embolization and vessel injury during transarterial chemoembolization were all significant predisposing factors for liver abscess after transarterial chemoembolization .", "sentence_id": 5}
+{"abstract_id": "24881853", "label": "results", "text": "A prediction model for postembolization liver abscess was developed from these risk factors .", "sentence_id": 6}
+{"abstract_id": "24881853", "label": "conclusions", "text": "The group of patients with risk scores greater than @ showed a significantly increased risk of liver abscess after transarterial chemoembolization .", "sentence_id": 7}
+{"abstract_id": "24881853", "label": "conclusions", "text": "These high-risk patients should be monitored carefully after transarterial chemoembolization .", "sentence_id": 8}
+{"abstract_id": "24302273", "label": "objective", "text": "Vascular disease is included in a risk scoring system to predict stroke in patients with non-valvular atrial fibrillation ( AF ) .", "sentence_id": 0}
+{"abstract_id": "24302273", "label": "objective", "text": "This post hoc analysis of ROCKET AF aimed to determine the absolute rates of stroke and bleeding , and the relative effectiveness and safety of rivaroxaban vs. warfarin in patients with and without peripheral artery disease ( PAD ) .", "sentence_id": 1}
+{"abstract_id": "24302273", "label": "objective", "text": "Peripheral artery disease was defined on the case-report form as the presences of intermittent claudication , amputation for arterial insufficiency , vascular reconstruction , bypass surgery , or percutaneous intervention to the extremities , or previously documented abdominal aortic aneurysm .", "sentence_id": 2}
+{"abstract_id": "24302273", "label": "results", "text": "ROCKET AF was a double-blind , double-dummy , randomized-controlled trial comparing rivaroxaban and warfarin for the prevention of stroke or systemic embolism .", "sentence_id": 3}
+{"abstract_id": "24302273", "label": "results", "text": "A total of @ ( @ % ) patients in ROCKET AF had PAD .", "sentence_id": 4}
+{"abstract_id": "24302273", "label": "results", "text": "Patients with and without PAD had similar rates of stroke or systemic embolism -LSB- HR : @ , @ % CI ( @ , @ ) , P = @ -RSB- and major or non-major clinically relevant ( NMCR ) bleeding -LSB- HR : @ , @ % CI ( @ , @ ) , P = @ -RSB- , respectively .", "sentence_id": 5}
+{"abstract_id": "24302273", "label": "results", "text": "The efficacy of rivaroxaban when compared with warfarin for the prevention of stroke or systemic embolism was similar in patients with PAD ( HR : @ , @ % CI : @-@ @ ) and without PAD ( HR : @ , @ % CI : @-@ @ ; interaction P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24302273", "label": "results", "text": "There was a significant interaction for major or NMCR bleeding in patients with PAD treated with rivaroxaban compared with warfarin ( HR : @ , @ % CI : @-@ @ ) compared with those without PAD ( HR : @ , @ % CI : @-@ @ ; interaction P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24302273", "label": "conclusions", "text": "Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD , and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin .", "sentence_id": 8}
+{"abstract_id": "24302273", "label": "conclusions", "text": "In PAD patients , there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin ( interaction P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24302273", "label": "conclusions", "text": "Further investigation is warranted to validate this subgroup analysis and determine the optimal treatment in this high-risk cohort of AF patients with PAD .", "sentence_id": 10}
+{"abstract_id": "24246588", "label": "background", "text": "Family members of patients with coronary artery disease ( CAD ) have higher risk of vascular events .", "sentence_id": 0}
+{"abstract_id": "24246588", "label": "background", "text": "We conducted a trial to determine if a family heart-health intervention could reduce their risk of CAD .", "sentence_id": 1}
+{"abstract_id": "24246588", "label": "methods", "text": "We assessed coronary risk factors and randomized @ family members of patients with CAD to a family heart-health intervention ( n = @ ) or control ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24246588", "label": "methods", "text": "The intervention included feedback about risk factors , assistance with goal setting and counselling from health educators for @ months .", "sentence_id": 3}
+{"abstract_id": "24246588", "label": "methods", "text": "Reports were sent to the primary care physicians of patients whose lipid levels and blood pressure exceeded threshold values .", "sentence_id": 4}
+{"abstract_id": "24246588", "label": "methods", "text": "All participants received printed materials about smoking cessation , healthy eating , weight management and physical activity ; the control group received only these materials .", "sentence_id": 5}
+{"abstract_id": "24246588", "label": "methods", "text": "The main outcomes ( ratio of total cholesterol to high-density lipoprotein -LSB- HDL -RSB- cholesterol ; physical activity ; fruit and vegetable consumption ) were assessed at @ and @ months .", "sentence_id": 6}
+{"abstract_id": "24246588", "label": "methods", "text": "We examined group and time effects using mixed models analyses with the baseline values as covariates .", "sentence_id": 7}
+{"abstract_id": "24246588", "label": "methods", "text": "The secondary outcomes were plasma lipid levels ( total cholesterol , low-density lipoprotein cholesterol , HDL cholesterol and triglycerides ) ; glucose level ; blood pressure ; smoking status ; waist circumference ; body mass index ; and the use of blood pressure , lipid-lowering and smoking cessation medications .", "sentence_id": 8}
+{"abstract_id": "24246588", "label": "results", "text": "We found no effect of the intervention on the ratio of total cholesterol to HDL cholesterol .", "sentence_id": 9}
+{"abstract_id": "24246588", "label": "results", "text": "However , participants in the intervention group reported consuming more fruit and vegetables ( @ servings per day more after @ mo and @ servings at @ mo ; p < @ ) .", "sentence_id": 10}
+{"abstract_id": "24246588", "label": "results", "text": "There was a significant group by time interaction for physical activity ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24246588", "label": "results", "text": "At @ months , those in the intervention group reported @ more minutes of physical activity per week ( @ % confidence interval -LSB- CI -RSB- @-@ @ min ) .", "sentence_id": 12}
+{"abstract_id": "24246588", "label": "results", "text": "At @ months , participants in the intervention group reported @ more minutes each week ( @ % CI @-@ @ min ) .", "sentence_id": 13}
+{"abstract_id": "24246588", "label": "conclusions", "text": "A health educator-led heart-health intervention did not improve the ratio of total cholesterol to HDL cholesterol but did increase reported physical activity and fruit and vegetable consumption among family members of patients with CAD .", "sentence_id": 14}
+{"abstract_id": "24246588", "label": "conclusions", "text": "Hospitalization of a spouse , sibling or parent is an opportunity to improve cardiovascular health among other family members .", "sentence_id": 15}
+{"abstract_id": "25133471", "label": "objective", "text": "To evaluate karyotype-specific ear and hearing problems in young-adult patients with Turner syndrome ( TS ) and assess the effects of previous treatment with oxandrolone ( Ox ) .", "sentence_id": 0}
+{"abstract_id": "25133471", "label": "methods", "text": "Double-blind follow-up study .", "sentence_id": 1}
+{"abstract_id": "25133471", "label": "methods", "text": "University hospital .", "sentence_id": 2}
+{"abstract_id": "25133471", "label": "methods", "text": "Sixty-five TS patients ( mean age , @ yr ) previously treated with growth hormone combined with placebo , Ox @ mg/kg per day , or Ox @ mg/kg per day from the age of @ years and estrogen from the age of @ years .", "sentence_id": 3}
+{"abstract_id": "25133471", "label": "methods", "text": "Ear examination was performed according to standard clinical practice .", "sentence_id": 4}
+{"abstract_id": "25133471", "label": "methods", "text": "Air - and bone conduction thresholds were measured in decibel hearing level .", "sentence_id": 5}
+{"abstract_id": "25133471", "label": "methods", "text": "We compared patients with total monosomy of the short arm of the X chromosome ( Xp ) , monosomy @ , X and isochromosome @ , X , i ( Xq ) , with patients with a partial monosomy Xp , mosaicism or other structural X chromosomal anomalies .", "sentence_id": 6}
+{"abstract_id": "25133471", "label": "methods", "text": "We assessed the effect of previous Ox treatment .", "sentence_id": 7}
+{"abstract_id": "25133471", "label": "results", "text": "Sixty-six percent of the patients had a history of recurrent otitis media .", "sentence_id": 8}
+{"abstract_id": "25133471", "label": "results", "text": "We found hearing loss in @ % of the ears , including pure sensorineural hearing loss in @ % .", "sentence_id": 9}
+{"abstract_id": "25133471", "label": "results", "text": "Hearing thresholds in patients with a complete monosomy Xp were about @ dB worse compared with those in patients with a partial monosomy Xp .", "sentence_id": 10}
+{"abstract_id": "25133471", "label": "results", "text": "Air - and bone conduction thresholds were not different between the placebo and Ox treatment groups .", "sentence_id": 11}
+{"abstract_id": "25133471", "label": "conclusions", "text": "Young-adult TS individuals frequently have structural ear pathology , and many suffer from hearing loss .", "sentence_id": 12}
+{"abstract_id": "25133471", "label": "conclusions", "text": "This indicates that careful follow-up to detect ear and hearing problems is necessary , especially for those with a monosomy @ , X or isochromosome @ , X , i ( Xq ) .", "sentence_id": 13}
+{"abstract_id": "25133471", "label": "conclusions", "text": "Ox does not seem to have an effect on hearing .", "sentence_id": 14}
+{"abstract_id": "25549577", "label": "objective", "text": "The aim was to investigate whether the fascia suture technique ( FST ) can reduce access closure time and procedural costs compared with the Prostar technique ( Prostar ) in patients undergoing endovascular aortic repair and to evaluate the short - and mid-term outcomes of both techniques .", "sentence_id": 0}
+{"abstract_id": "25549577", "label": "methods", "text": "In this two center trial , @ patients were randomized to access closure by either FST or Prostar between June @ and December @ .", "sentence_id": 1}
+{"abstract_id": "25549577", "label": "methods", "text": "The primary endpoint was access closure time .", "sentence_id": 2}
+{"abstract_id": "25549577", "label": "methods", "text": "Secondary outcome measures included access related costs and evaluation of the short - and mid-term complications .", "sentence_id": 3}
+{"abstract_id": "25549577", "label": "methods", "text": "Evaluation was performed peri - and post-operatively , at discharge , at @ days and at @ months follow up .", "sentence_id": 4}
+{"abstract_id": "25549577", "label": "results", "text": "The median access closure time was @ minutes for FST and @ minutes for Prostar ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25549577", "label": "results", "text": "Prostar required a @ % greater procedure time than FST , mean ratio @ ( @ % CI @-@ @ , p < @ ) according to regression analysis .", "sentence_id": 6}
+{"abstract_id": "25549577", "label": "results", "text": "Adjusted for operator experience the mean ratio was @ ( @ % CI @-@ @ , p = @ ) and for patient body mass index @ ( @ % CI @-@ @ , p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25549577", "label": "results", "text": "The technical failure rate for operators at proficiency level was @ % ( @/@ ) compared with @ % ( @/@ ) for those at the basic level ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "25549577", "label": "results", "text": "The proficiency level group had a technical failure rate of @ % ( @/@ ) for FST and @ % ( @/@ ) for Prostar , p = @ , while corresponding rates for the basic level group were @ % ( @/@ ) for FST and @ % ( @/@ ) for Prostar ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25549577", "label": "results", "text": "There was a significant difference in cost in favor of FST , with a median difference of @ ( @ % CI @-@ , p < @ ) .", "sentence_id": 10}
+{"abstract_id": "25549577", "label": "conclusions", "text": "In aortic endovascular repair FST is a faster and cheaper technique than the Prostar technique .", "sentence_id": 11}
+{"abstract_id": "25003731", "label": "background", "text": "Correct use of intranasal corticosteroid ( INCS ) and compliance with treatment is very important for the treatment of allergic rhinitis ( AR ) .", "sentence_id": 0}
+{"abstract_id": "25003731", "label": "background", "text": "An animated cartoon-aided teaching method for INCS administration was created to decrease the workload of health care professionals .", "sentence_id": 1}
+{"abstract_id": "25003731", "label": "background", "text": "The aim of this study was to compare the performance of children with AR in using INCS between a group who were instructed using animated cartoon-aided teaching and those receiving only an oral presentation without demonstration .", "sentence_id": 2}
+{"abstract_id": "25003731", "label": "methods", "text": "The study was a prospective randomized controlled trial in children aged @-@ years with moderate to severe intermittent or persistent AR who had never used INCS .", "sentence_id": 3}
+{"abstract_id": "25003731", "label": "methods", "text": "The patients were randomly divided into @ groups ; @ ) those receiving teaching about how to use INCS by an oral presentation without demonstration and @ ) by animated cartoon-aided teaching .", "sentence_id": 4}
+{"abstract_id": "25003731", "label": "methods", "text": "The performance of the children was recorded after the initial training using a five-point checklist .", "sentence_id": 5}
+{"abstract_id": "25003731", "label": "methods", "text": "If they were unable to use the INCS correctly after the first teaching session , the same instructions were repeated and a second assessment was performed .", "sentence_id": 6}
+{"abstract_id": "25003731", "label": "results", "text": "A total of @ patients , @ each group , underwent randomization .", "sentence_id": 7}
+{"abstract_id": "25003731", "label": "results", "text": "The rate of achieving competency for the patients after the first instruction using the animated cartoon-aided teaching group was significantly higher than that for the oral presentation group ( @ % VS @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25003731", "label": "results", "text": "The cumulative success rate for the second assessment of the animated cartoon-aided group was also significantly higher than for those receiving only an oral presentation ( @ % VS @ % , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25003731", "label": "conclusions", "text": "With regard to mastering the correct method for INCS usage , instruction using animated cartoon-aided teaching is better than oral presentation without demonstration .", "sentence_id": 10}
+{"abstract_id": "25003731", "label": "conclusions", "text": "However , the best method for teaching patients how to use INCS is a combination of oral explanation and demonstration by cartoon-aided teaching .", "sentence_id": 11}
+{"abstract_id": "25003731", "label": "conclusions", "text": "The teaching should be repeated periodically to remind patients of the correct method for INCS usage .", "sentence_id": 12}
+{"abstract_id": "25436661", "label": "objective", "text": "In rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) forefoot involvement causes disability and metatarsalgia .", "sentence_id": 0}
+{"abstract_id": "25436661", "label": "objective", "text": "Our objective was to evaluate , in RA and OA patients , the efficacy of two protocols combining insoles in polypropylene terephtalate ( PPT ) and custom silicone orthoses for toes on disability and metatarsalgia .", "sentence_id": 1}
+{"abstract_id": "25436661", "label": "methods", "text": "Twenty-four women ( @ with OA , @ with RA ) with metatarsalgia were treated with two protocols : group A ( protocol A ) wore PPT insoles ( T@ ) for @ days and for another @ days silicone orthosis for toes were added ( T@ ) .", "sentence_id": 2}
+{"abstract_id": "25436661", "label": "methods", "text": "Group B ( protocol B ) wore PPT insoles and silicone orthosis ( T@ ) for @ days and in the following @ days only insoles ( T@ ) .", "sentence_id": 3}
+{"abstract_id": "25436661", "label": "methods", "text": "At T@ , T@ and T@ , pain , disability and function ( Foot Function Index - FFI ) , pressure ( KPA ) and plantar contact areas ( cm@ ) ( baropodometer ) , and gait spatial-temporal parameters ( GAITRite ) were assessed .", "sentence_id": 4}
+{"abstract_id": "25436661", "label": "results", "text": "At T@ versus T@ , both protocols reduced FFI-pain , - disability and - functional limitation ( p < @ ) , with better results of protocol A than protocol B ( p < @ ) for FFI-pain and - disability .", "sentence_id": 5}
+{"abstract_id": "25436661", "label": "results", "text": "Both protocols reduced baropodometer foot plantar pressures ( p < @ ) , with better results for protocol A for right foot pressures ( p < @ ) and increased foot contact areas ( p < @ ) , with no difference between them ( p = NS ) .", "sentence_id": 6}
+{"abstract_id": "25436661", "label": "results", "text": "Gait parameters were not significantly changed by both protocols ( p = NS ) .", "sentence_id": 7}
+{"abstract_id": "25436661", "label": "conclusions", "text": "In patients with RA and OA with metatarsalgia , the synergic action of silicone toe orthosis and PPT insoles improves FFI , reduces foot plantar pressures and increases foot plantar contact areas .", "sentence_id": 8}
+{"abstract_id": "25436661", "label": "conclusions", "text": "Protocol A , using firstly insoles and then adding silicone toe orthoses , is the more efficacious .", "sentence_id": 9}
+{"abstract_id": "24635872", "label": "background", "text": "Persistent behavioural difficulties are common following paediatric acquired brain injury ( ABI ) .", "sentence_id": 0}
+{"abstract_id": "24635872", "label": "background", "text": "Parents and families also experience heightened stress , psychological symptoms and burden , and there is evidence of a reciprocal relationship between parent and child functioning , which may be mediated by the adoption of maladaptive parenting practices .", "sentence_id": 1}
+{"abstract_id": "24635872", "label": "background", "text": "Despite this , there is currently a paucity of research in family interventions in this population .", "sentence_id": 2}
+{"abstract_id": "24635872", "label": "background", "text": "The aim of this study was to determine the efficacy of Stepping Stones Triple P : Positive Parenting Program ( SSTP ) , with an Acceptance and Commitment Therapy ( ACT ) workshop , in improving child outcomes and parenting practices following paediatric ABI .", "sentence_id": 3}
+{"abstract_id": "24635872", "label": "methods", "text": "Fifty-nine parents of children ( mean age @ years , SD @ years , @ month ; @ males , @ females ) with ABI ( Traumatic injuries @ % , Tumour @ % , Encephalitis or meningitis @ % , Cardiovascular accident @ % , Hypoxia @ % ) who were evidencing at least mild behaviour problems were randomly assigned to treatment or care-as-usual conditions over @ weeks .", "sentence_id": 4}
+{"abstract_id": "24635872", "label": "methods", "text": "Mixed-model repeated-measures linear regression analyses were conducted to compare conditions from pre - to postintervention on child behavioural and emotional functioning ( Eyberg Child Behavior Inventory , Strengths and Difficulties Questionnaire ) and dysfunctional parenting style ( Parenting Scale ) .", "sentence_id": 5}
+{"abstract_id": "24635872", "label": "methods", "text": "Assessment of maintenance of change was conducted at a @-month follow-up .", "sentence_id": 6}
+{"abstract_id": "24635872", "label": "methods", "text": "The trial was registered on Australian New Zealand Clinical Trials Registry ( ID : ACTRN@ , www.anzctr.org.au ) .", "sentence_id": 7}
+{"abstract_id": "24635872", "label": "results", "text": "Significant time-by-condition interactions were identified on number and intensity of child behaviour problems , child emotional symptoms and parenting laxness and overreactivity , indicating significant improvements in the treatment condition , with medium-to-large effect sizes .", "sentence_id": 8}
+{"abstract_id": "24635872", "label": "results", "text": "Most improvements were maintained at @ months .", "sentence_id": 9}
+{"abstract_id": "24635872", "label": "conclusions", "text": "Group parenting interventions incorporating Triple P and ACT may be efficacious in improving child and parenting outcomes following paediatric ABI .", "sentence_id": 10}
+{"abstract_id": "25363189", "label": "objective", "text": "The purpose of this study is the comparison of the effect of vitamin B@ and fish oil with together on severity and duration of dysmenorrhea , and if it is effective , we can administrative both of them with less complication to compare with other chemical drugs which has many disadvantages .", "sentence_id": 0}
+{"abstract_id": "25363189", "label": "methods", "text": "High school of Urmia city , between March @ and June @ .", "sentence_id": 1}
+{"abstract_id": "25363189", "label": "methods", "text": "This study has a double-blind clinical trial design @ high school female students with dysmenorrhea by a randomized Method were followed up in a double-blind , randomized , placebo-controlled study by dividing into four groups with @ members .", "sentence_id": 2}
+{"abstract_id": "25363189", "label": "methods", "text": "The daily supplement was vit B@ ( @ mg/day and fish oil pearl @ mg/day ) , taken as a single dose starting at the beginning of the menstrual cycle and continued for @ consecutive months .", "sentence_id": 3}
+{"abstract_id": "25363189", "label": "results", "text": "Intensity of pain in three experimental groups ( Vit B@ , fish oil and both of them ) had significant difference comparing placebo group and intensity of pain had reduced .", "sentence_id": 4}
+{"abstract_id": "25363189", "label": "results", "text": "( p < @ ) , ( p = @ ) , ( p < @ ) VS in placebo group ( p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25363189", "label": "results", "text": "Duration of pain had significantly reduced in all three experimental groups compared with placebo group .", "sentence_id": 6}
+{"abstract_id": "25363189", "label": "results", "text": "( p = @ ) , ( p = @ ) , ( p < @ ) VS in placebo group ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25363189", "label": "results", "text": "In all of drugs , results ( mean ) was better at the end of the second month than the first month .", "sentence_id": 8}
+{"abstract_id": "25363189", "label": "conclusions", "text": "Fish oil and vit B@ effects on treatment of primary dysmenorrhea were similar , but vit B@ has less complications and it was more acceptable .", "sentence_id": 9}
+{"abstract_id": "25363189", "label": "conclusions", "text": "We mixed them and compared its results with vit B@ , fish oil and placebo separately .", "sentence_id": 10}
+{"abstract_id": "25363189", "label": "conclusions", "text": "Pain duration is the least in Vitamin B@ tablets compare with the others , but its duration was minimum in complex of Vitamin B@ tablets and fish oil capsules .", "sentence_id": 11}
+{"abstract_id": "25363189", "label": "conclusions", "text": "Due to good effects of vitamin B@ and fish oil on symptoms of dysmenorrhea , using of them is suggested .", "sentence_id": 12}
+{"abstract_id": "24763929", "label": "objective", "text": "Exercise using virtual reality ( VR ) has improved balance in adults with traumatic brain injury and community-dwelling older adults .", "sentence_id": 0}
+{"abstract_id": "24763929", "label": "objective", "text": "Rigorous randomized studies regarding its efficacy , safety , and applicability with individuals after stroke are lacking .", "sentence_id": 1}
+{"abstract_id": "24763929", "label": "objective", "text": "The purpose of this study was to determine whether an adjunct VR therapy improves balance , mobility , and gait in stroke rehabilitation inpatients .", "sentence_id": 2}
+{"abstract_id": "24763929", "label": "methods", "text": "A blinded randomized controlled trial studying @ stroke survivors on an inpatient stroke rehabilitation unit was performed .", "sentence_id": 3}
+{"abstract_id": "24763929", "label": "methods", "text": "The treatment group ( n = @ ) received standard stroke rehabilitation therapy plus a program of VR exercises that challenged balance ( eg , soccer goaltending , snowboarding ) performed while standing .", "sentence_id": 4}
+{"abstract_id": "24763929", "label": "methods", "text": "The control group ( n = @ ) received standard stroke rehabilitation therapy plus exposure to identical VR environments but whose games did not challenge balance ( performed in sitting ) .", "sentence_id": 5}
+{"abstract_id": "24763929", "label": "methods", "text": "VR training consisted of @ to @ thirty-minute daily sessions for a @-week period .", "sentence_id": 6}
+{"abstract_id": "24763929", "label": "methods", "text": "Objective outcome measures of balance and mobility were assessed before , immediately after , and @ month after training .", "sentence_id": 7}
+{"abstract_id": "24763929", "label": "results", "text": "Confidence intervals and effect sizes favored the treatment group on the Timed Up and Go and the Two-Minute Walk Test , with both groups meeting minimal clinical important differences after training .", "sentence_id": 8}
+{"abstract_id": "24763929", "label": "results", "text": "More individuals in the treatment group than in the control group showed reduced impairment in the lower extremity as measured by the Chedoke McMaster Leg domain ( P = @ ) immediately after training .", "sentence_id": 9}
+{"abstract_id": "24763929", "label": "conclusions", "text": "This VR exercise intervention for inpatient stroke rehabilitation improved mobility-related outcomes .", "sentence_id": 10}
+{"abstract_id": "24763929", "label": "conclusions", "text": "Future studies could include nonambulatory participants as well as the implementation strategies for the clinical use of VR .", "sentence_id": 11}
+{"abstract_id": "25446768", "label": "background", "text": "Amino-acid-based formulas ( AAFs ) are recommended for children with cow 's milk protein allergy ( CMPA ) failing to respond to extensively hydrolyzed formulas ( eHFs ) .", "sentence_id": 0}
+{"abstract_id": "25446768", "label": "objective", "text": "This study aimed to assess the tolerance/hypoallergenicity and efficacy of a thickened AAF ( TAAF ) in these infants .", "sentence_id": 1}
+{"abstract_id": "25446768", "label": "methods", "text": "This multicenter , double-blind , randomized controlled trial ( NCT@ ) compared @-month feeding with a pectin-based TAAF ( Novalac ( ) , United Pharmaceuticals , Paris , France ) and a commercially available `` reference '' AAF ( RAAF ; Neocate ( ) , Nutricia , Germany ) in infants aged < @ months with CMPA and persistent allergy symptoms with eHF feeding .", "sentence_id": 2}
+{"abstract_id": "25446768", "label": "methods", "text": "Reported here are the results of an interim analysis after @ month of feeding .", "sentence_id": 3}
+{"abstract_id": "25446768", "label": "results", "text": "Of the @ infants randomized , CMPA with eHF intolerance was confirmed in @ infants ; all of them tolerated the allocated AAFs .", "sentence_id": 4}
+{"abstract_id": "25446768", "label": "results", "text": "The major allergic symptom disappeared within @ month in @ and @ % and regurgitations disappeared in @ and @ % of infants who received TAAF and RAAF , respectively .", "sentence_id": 5}
+{"abstract_id": "25446768", "label": "results", "text": "Infants had significantly more normal stools ( soft or formed consistency ) with the TAAF ( @ vs. @ % ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25446768", "label": "results", "text": "From baseline , daily family life significantly improved with both AAFs : crying time decreased by @ ( p < @ ) and @ min ( p = @ ) and sleeping time increased by @ ( p = @ ) and @ min with TAAF and RAAF , respectively .", "sentence_id": 7}
+{"abstract_id": "25446768", "label": "results", "text": "At day @ , weight and body mass index z-score gains were @ and @ with TAAF and @ and @ with RAAF .", "sentence_id": 8}
+{"abstract_id": "25446768", "label": "conclusions", "text": "Both AAFs were well tolerated by infants with CMPA and eHF intolerance and ensured appropriate growth , with the TAAF providing additional comfort .", "sentence_id": 9}
+{"abstract_id": "25384603", "label": "objective", "text": "The aim of this study was to investigate the influence of perioperative N-acetylcysteine ( NAC ) administration , a known antioxidant , on the incidence of acute kidney injury ( AKI ) after off-pump coronary bypass surgery ( OPCAB ) in patients with known risk factors of AKI .", "sentence_id": 0}
+{"abstract_id": "25384603", "label": "methods", "text": "One hundred and seventeen patients with @ of the following risk factors of AKI were randomized into either the control ( n = @ ) or the NAC ( n = @ ) group ; ( i ) preoperative serum creatinine > @ mg/dL ; ( ii ) left ventricular ejection fraction < @ % or congestive heart failure ( iii ) age > @ years ( iv ) diabetes or ( v ) re-operation .", "sentence_id": 1}
+{"abstract_id": "25384603", "label": "methods", "text": "Patients in the NAC group received @mg/kg of NAC IV bolus at anaesthetic induction followed by a continuous infusion at @mg/kg per day for @h .", "sentence_id": 2}
+{"abstract_id": "25384603", "label": "methods", "text": "AKI was diagnosed based on Acute Kidney Injury Network criteria during @h postoperatively .", "sentence_id": 3}
+{"abstract_id": "25384603", "label": "results", "text": "The incidence of AKI was @ % ( @/@ ) and @ % ( @/@ ) in the control and the NAC group , respectively ( P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25384603", "label": "results", "text": "The serum concentrations of creatinine and cystatin C were similar between the groups throughout the study period .", "sentence_id": 5}
+{"abstract_id": "25384603", "label": "results", "text": "Fluid balance including the amount of blood loss and transfusion requirement were similar between the groups except the amount of postoperative urine output , which was higher in the control group compared with the NAC group ( @mL vs. @mL , control vs. NAC , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25384603", "label": "conclusions", "text": "Perioperative administration of NAC did not prevent the development of postoperative AKI after OPCAB in highly susceptible patients to AKI .", "sentence_id": 7}
+{"abstract_id": "24399101", "label": "objective", "text": "To evaluate the efficacy of @ computer attention training systems administered in school for children with attention-deficit hyperactivity disorder ( ADHD ) .", "sentence_id": 0}
+{"abstract_id": "24399101", "label": "methods", "text": "Children in second and fourth grade with a diagnosis of ADHD ( n = @ ) were randomly assigned to neurofeedback ( NF ) ( n = @ ) , cognitive training ( CT ) ( n = @ ) , or control ( n = @ ) conditions .", "sentence_id": 1}
+{"abstract_id": "24399101", "label": "methods", "text": "A @-point growth model assessed change from pre-post intervention on parent reports ( Conners @-Parent -LSB- Conners @-P -RSB- ; Behavior Rating Inventory of Executive Function -LSB- BRIEF -RSB- rating scale ) , teacher reports ( Swanson , Kotkin , Agler , M-Flynn and Pelham scale -LSB- SKAMP -RSB- ; Conners @-Teacher -LSB- Conners @-T -RSB- ) , and systematic classroom observations ( Behavioral Observation of Students in Schools -LSB- BOSS -RSB- ) .", "sentence_id": 2}
+{"abstract_id": "24399101", "label": "methods", "text": "Paired t tests and an analysis of covariance assessed change in medication .", "sentence_id": 3}
+{"abstract_id": "24399101", "label": "results", "text": "Children who received NF showed significant improvement compared with those in the control condition on the Conners @-P Attention , Executive Functioning and Global Index , on all BRIEF summary indices , and on BOSS motor/verbal off-task behavior .", "sentence_id": 4}
+{"abstract_id": "24399101", "label": "results", "text": "Children who received CT showed no improvement compared to the control condition .", "sentence_id": 5}
+{"abstract_id": "24399101", "label": "results", "text": "Children in the NF condition showed significant improvements compared to those in the CT condition on Conners @-P Executive Functioning , all BRIEF summary indices , SKAMP Attention , and Conners @-T Inattention subscales .", "sentence_id": 6}
+{"abstract_id": "24399101", "label": "results", "text": "Stimulant medication dosage in methylphenidate equivalencies significantly increased for children in the CT ( @ mg ) and control ( @ mg ) conditions but not for those in the NF condition ( @ mg ) .", "sentence_id": 7}
+{"abstract_id": "24399101", "label": "conclusions", "text": "Neurofeedback made greater improvements in ADHD symptoms compared to both the control and CT conditions .", "sentence_id": 8}
+{"abstract_id": "24399101", "label": "conclusions", "text": "Thus , NF is a promising attention training treatment intervention for children with ADHD .", "sentence_id": 9}
+{"abstract_id": "25281755", "label": "background", "text": "The efficacy of TCN-@ , a human monoclonal antibody targeting a conserved epitope on M@e , was explored in experimental human influenza .", "sentence_id": 0}
+{"abstract_id": "25281755", "label": "methods", "text": "Healthy volunteers were inoculated with influenza A/Wisconsin/@ / @ ( H@N@ ) and received a single dose of the study drug , TCN-@ , or placebo @ hours later .", "sentence_id": 1}
+{"abstract_id": "25281755", "label": "methods", "text": "Subjects were monitored for symptoms , viral shedding , and safety , including cytokine measurements .", "sentence_id": 2}
+{"abstract_id": "25281755", "label": "methods", "text": "Oseltamivir was administered @ days after inoculation .", "sentence_id": 3}
+{"abstract_id": "25281755", "label": "results", "text": "Although the primary objective of reducing the proportion of subjects developing any grade @ influenza symptom or pyrexia , was not achieved , TCN-@-treated subjects showed @ % reduction ( P = @ ) in median total symptom area under the curve ( days @-@ ) and @ log reduction in median viral load area under the curve ( days @-@ ) by quantitative polymerase chain reaction ( P = @ ) compared with placebo-treated subjects .", "sentence_id": 4}
+{"abstract_id": "25281755", "label": "results", "text": "TCN-@ was safe and well tolerated with no additional safety signals after administration of oseltamivir .", "sentence_id": 5}
+{"abstract_id": "25281755", "label": "results", "text": "Serum cytokine levels ( interferon , tumor necrosis factor , and interleukin @ and @ ) were similar in both groups .", "sentence_id": 6}
+{"abstract_id": "25281755", "label": "results", "text": "Genotypic and phenotypic analyses showed no difference between virus derived from subjects after TCN-@ treatment and parental strain .", "sentence_id": 7}
+{"abstract_id": "25281755", "label": "conclusions", "text": "These data indicate that TCN-@ may provide immediate immunity and therapeutic benefit in influenza A infection , with no apparent emergence of resistant virus .", "sentence_id": 8}
+{"abstract_id": "25281755", "label": "conclusions", "text": "TCN-@ was safe with no evidence of immune exacerbation based on serum cytokine expression .", "sentence_id": 9}
+{"abstract_id": "25281755", "label": "conclusions", "text": "Clinicaltrials.gov registry number.NCT@ .", "sentence_id": 10}
+{"abstract_id": "24809142", "label": "objective", "text": "To observe the impact of the diverse caloric energy intake on the outcomes and occurrence rate of complications in septic patients .", "sentence_id": 0}
+{"abstract_id": "24809142", "label": "methods", "text": "A prospective single-blind randomized controlled trial was conducted .", "sentence_id": 1}
+{"abstract_id": "24809142", "label": "methods", "text": "@ cases of septic patients in intensive care unit ( ICU ) were enrolled and randomly assigned to three groups according to their different target value of nutrition : group A -LSB- measurements of resting energy expenditure ( MREE ) < @ % J , B ( MREE @ % -@ % ) and C ( MREE > @ % ) .", "sentence_id": 2}
+{"abstract_id": "24809142", "label": "methods", "text": "The caloric intake , mechanical ventilation duration ( MVD ) , nosocomial infection rate , @-day and @-day mortality were analyzed .", "sentence_id": 3}
+{"abstract_id": "24809142", "label": "results", "text": "Daily energy intake in @ days after ICU admission was as follows : the difference in target value of nutrition ( kJ/d : @ @ @ @ , @ @ @ @,@ @ @ @ ) , calory intake ( k -RSB- / d : @ @ @ @ , @ @ @ @ , @ @ @ @ ) , enteral nutrition value ( kJ/d : @ @ @ @ , @ @ @ @ , @ @ @ @ ) and average intake rate -LSB- ( @ @ ) % , ( @ @ ) % , ( @ @ ) % J , and they were statistically significant difference among A , B , C groups ( all P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24809142", "label": "results", "text": "The parenteral nutrition in group C were much higher than that in group A and group B ( kJ/d : @ @ @ vs. @ @ , @ @ , both P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24809142", "label": "results", "text": "The calories provided by glucose and diprivan were similar among three groups .", "sentence_id": 6}
+{"abstract_id": "24809142", "label": "results", "text": "The MVD and ICU stay were shorter in group B than that in groups A and C -LSB- MVD ( days ) : @ @ vs. @ @ , @ @ , P > @ and P < @ ; ICU stay ( days ) : @ @ vs. @ @ , @ @ , respectively , P > @ and P < @ -RSB- .", "sentence_id": 7}
+{"abstract_id": "24809142", "label": "results", "text": "The total hospital stay ( days : @ @ , @ @ , @ @ ) and nosocomial infection rate -LSB- @ % ( @ ) , @ % ( @/@ ) , @ % ( @@/@ ) J were similar among A , B , C groups ( all P > @ ) .", "sentence_id": 8}
+{"abstract_id": "24809142", "label": "results", "text": "There was no difference in survival rate at @ days among three groups as shown by the Kaplan-Meier survival curve ( F = @ , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24809142", "label": "results", "text": "The survival rate at @ days showed a tendency of lowering in groups A and C , especially in group C ( F = @ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24809142", "label": "conclusions", "text": "Both higher and lower caloric energy intake may be associated with an adverse impact , but appropriate caloric intake would improve the outcome and reduce the complication rate in septic patients .", "sentence_id": 11}
+{"abstract_id": "26138912", "label": "objective", "text": "A prognostic model for @-year overall survival ( OS ) , consisting of recursive partitioning analysis ( RPA ) and a nomogram , was developed for patients with early-stage non-small cell lung cancer ( ES-NSCLC ) treated with stereotactic ablative radiation therapy ( SABR ) .", "sentence_id": 0}
+{"abstract_id": "26138912", "label": "methods", "text": "A primary dataset of @ ES-NSCLC SABR patients was randomly divided into a training ( @ % ) and an internal validation ( @ % ) dataset .", "sentence_id": 1}
+{"abstract_id": "26138912", "label": "methods", "text": "In the former group , @ unique parameters consisting of patient , treatment , and tumor factors were entered into an RPA model to predict OS .", "sentence_id": 2}
+{"abstract_id": "26138912", "label": "methods", "text": "Univariate and multivariate models were constructed for RPA-selected factors to evaluate their relationship with OS .", "sentence_id": 3}
+{"abstract_id": "26138912", "label": "methods", "text": "A nomogram for OS was constructed based on factors significant in multivariate modeling and validated with calibration plots .", "sentence_id": 4}
+{"abstract_id": "26138912", "label": "methods", "text": "Both the RPA and the nomogram were externally validated in independent surgical ( n = @ ) and SABR ( n = @ ) datasets .", "sentence_id": 5}
+{"abstract_id": "26138912", "label": "results", "text": "RPA identified @ distinct risk classes based on tumor diameter , age , World Health Organization performance status ( PS ) and Charlson comorbidity index .", "sentence_id": 6}
+{"abstract_id": "26138912", "label": "results", "text": "This RPA had moderate discrimination in SABR datasets ( c-index range : @-@ @ ) but was of limited value in the surgical validation cohort .", "sentence_id": 7}
+{"abstract_id": "26138912", "label": "results", "text": "The nomogram predicting OS included smoking history in addition to RPA-identified factors .", "sentence_id": 8}
+{"abstract_id": "26138912", "label": "results", "text": "In contrast to RPA , validation of the nomogram performed well in internal validation ( r ( @ ) = @ ) and external SABR ( r ( @ ) = @ ) and surgical cohorts ( r ( @ ) = @ ) .", "sentence_id": 9}
+{"abstract_id": "26138912", "label": "conclusions", "text": "The Amsterdam prognostic model is the first externally validated prognostication tool for OS in ES-NSCLC treated with SABR available to individualize patient decision making .", "sentence_id": 10}
+{"abstract_id": "26138912", "label": "conclusions", "text": "The nomogram retained strong performance across surgical and SABR external validation datasets .", "sentence_id": 11}
+{"abstract_id": "26138912", "label": "conclusions", "text": "RPA performance was poor in surgical patients , suggesting that @ different distinct patient populations are being treated with these @ effective modalities .", "sentence_id": 12}
+{"abstract_id": "24928191", "label": "objective", "text": "To investigate ( @ ) the effect of spray and stretch versus control on reducing postneedling soreness of @ latent myofascial trigger point ( MTrP ) and ( @ ) whether higher levels of psychological distress are associated with increased postneedling pain intensity .", "sentence_id": 0}
+{"abstract_id": "24928191", "label": "methods", "text": "A @-hour follow-up , single-blind randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "24928191", "label": "methods", "text": "University community .", "sentence_id": 2}
+{"abstract_id": "24928191", "label": "methods", "text": "Healthy volunteers ( N = @ ; @ men , @ women ) aged @ to @ years ( mean age , @y ) with latent MTrP in @ upper trapezius muscle .", "sentence_id": 3}
+{"abstract_id": "24928191", "label": "methods", "text": "All subjects received a dry needling application over the upper trapezius muscle .", "sentence_id": 4}
+{"abstract_id": "24928191", "label": "methods", "text": "Then , participants were randomly divided into @ groups : an intervention group , which received spray and stretch over the needled trapezius muscle , and a control group , which did not receive any intervention .", "sentence_id": 5}
+{"abstract_id": "24928191", "label": "methods", "text": "Visual analog scale ( at postneedling , posttreatment , and @ , @ , @ , @ , and @h after needling ) , pressure pain threshold ( at preneedling , postneedling , and @ and @h after needling ) .", "sentence_id": 6}
+{"abstract_id": "24928191", "label": "methods", "text": "Psychological distress was evaluated by using the Symptom Checklist-@-Revised .", "sentence_id": 7}
+{"abstract_id": "24928191", "label": "results", "text": "Repeated-measures analysis of variance demonstrated a significant interaction between group and time ( F@ ,@ = @ ; P < @ ; p ( @ ) = @ ) for changes in postneedling soreness .", "sentence_id": 8}
+{"abstract_id": "24928191", "label": "results", "text": "Between-group differences were significant only immediately after intervention ( P = @ ) , and there were no differences found between groups after @ hours of the intervention ( P > @ ) .", "sentence_id": 9}
+{"abstract_id": "24928191", "label": "results", "text": "Repeated measures of covariance showed that none of the psychological covariates affected these results .", "sentence_id": 10}
+{"abstract_id": "24928191", "label": "results", "text": "Somatization , anxiety , interpersonal sensitivity , and hostility were significantly correlated ( P < @ ) with postneedling pain intensity .", "sentence_id": 11}
+{"abstract_id": "24928191", "label": "results", "text": "Repeated-measures analysis of variance did not show a significant effect of spray and stretch on mechanical hyperalgesia ( F@ @,@ = @ ; P = @ ; p ( @ ) = @ ) .", "sentence_id": 12}
+{"abstract_id": "24928191", "label": "conclusions", "text": "The spray and stretch had a short-term ( < @h ) effect in reducing postneedling soreness of a latent MTrP .", "sentence_id": 13}
+{"abstract_id": "24928191", "label": "conclusions", "text": "Pressure pain threshold did not significantly change after spray and stretch .", "sentence_id": 14}
+{"abstract_id": "24928191", "label": "conclusions", "text": "Psychological factors are related to postneedling pain .", "sentence_id": 15}
+{"abstract_id": "24385634", "label": "objective", "text": "To longitudinally examine gender and racial disparities in driving cessation among older adults .", "sentence_id": 0}
+{"abstract_id": "24385634", "label": "methods", "text": "Data came from the Advanced Cognitive Training for Independent and Vital Elderly ( ACTIVE ) Study ( N = @,@ ) .", "sentence_id": 1}
+{"abstract_id": "24385634", "label": "methods", "text": "Logistic generalized estimating equations ( GEE ) were used to identify predictors of driving cessation ; stratified analysis and interaction terms were used to determine whether factors differed by gender and race .", "sentence_id": 2}
+{"abstract_id": "24385634", "label": "results", "text": "Two hundred and five ( @ % ) participants stopped driving over the study period .", "sentence_id": 3}
+{"abstract_id": "24385634", "label": "results", "text": "Education was associated with increased risk of cessation for men ( adjusted odds ratio -LSB- AOR -RSB- = @ , @ % confidence interval -LSB- CI -RSB- = @ to @ ) , but decreased risk for women ( AOR = @ , @ % CI = @-@ @ ) .", "sentence_id": 4}
+{"abstract_id": "24385634", "label": "results", "text": "Being married was associated with lower risk of cessation for men ( AOR = @ , @ % CI = @-@ @ ) but was unrelated to cessation for women ( AOR = @ , @ % CI = @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "24385634", "label": "results", "text": "Results were consistent with the hypothesis that racial disparities in cessation widen with increasing age .", "sentence_id": 6}
+{"abstract_id": "24385634", "label": "conclusions", "text": "Factors predictive of driving cessation vary by gender .", "sentence_id": 7}
+{"abstract_id": "24385634", "label": "conclusions", "text": "Racial disparities in cessation are wider at older ages .", "sentence_id": 8}
+{"abstract_id": "24385634", "label": "conclusions", "text": "Transportation policies and programs should account for social determinants and aim to address social disparities in driving mobility among older adults .", "sentence_id": 9}
+{"abstract_id": "25980660", "label": "objective", "text": "Noninvasive ventilation delivered as bilevel positive airway pressure ( BiPAP ) is often used to avoid reintubation and improve outcomes of patients with hypoxemia after cardiothoracic surgery .", "sentence_id": 0}
+{"abstract_id": "25980660", "label": "objective", "text": "High-flow nasal oxygen therapy is increasingly used to improve oxygenation because of its ease of implementation , tolerance , and clinical effectiveness .", "sentence_id": 1}
+{"abstract_id": "25980660", "label": "objective", "text": "To determine whether high-flow nasal oxygen therapy was not inferior to BiPAP for preventing or resolving acute respiratory failure after cardiothoracic surgery .", "sentence_id": 2}
+{"abstract_id": "25980660", "label": "methods", "text": "Multicenter , randomized , noninferiority trial ( BiPOP Study ) conducted between June @ , @ , and January @ , @ , at @ French intensive care units .", "sentence_id": 3}
+{"abstract_id": "25980660", "label": "methods", "text": "A total of @ patients who had undergone cardiothoracic surgery , of which coronary artery bypass , valvular repair , and pulmonary thromboendarterectomy were the most common , were included when they developed acute respiratory failure ( failure of a spontaneous breathing trial or successful breathing trial but failed extubation ) or were deemed at risk for respiratory failure after extubation due to preexisting risk factors .", "sentence_id": 4}
+{"abstract_id": "25980660", "label": "methods", "text": "Patients were randomly assigned to receive high-flow nasal oxygen therapy delivered continuously through a nasal cannula ( flow , @ L/min ; fraction of inspired oxygen -LSB- FiO@ -RSB- , @ % ) ( n = @ ) or BiPAP delivered with a full-face mask for at least @ hours per day ( pressure support level , @ cm H@O ; positive end-expiratory pressure , @ cm H@O ; FiO@ , @ % ) ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25980660", "label": "methods", "text": "The primary outcome was treatment failure , defined as reintubation , switch to the other study treatment , or premature treatment discontinuation ( patient request or adverse effects , including gastric distention ) .", "sentence_id": 6}
+{"abstract_id": "25980660", "label": "methods", "text": "Noninferiority of high-flow nasal oxygen therapy would be demonstrated if the lower boundary of the @ % CI were less than @ % .", "sentence_id": 7}
+{"abstract_id": "25980660", "label": "methods", "text": "Secondary outcomes included mortality during intensive care unit stay , changes in respiratory variables , and respiratory complications .", "sentence_id": 8}
+{"abstract_id": "25980660", "label": "results", "text": "High-flow nasal oxygen therapy was not inferior to BiPAP : the treatment failed in @ of @ patients with high-flow nasal oxygen therapy ( @ % ) and @ of @ patients with BiPAP ( @ % ) ( absolute difference , @ % ; @ % CI , -@ % to @ % ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25980660", "label": "results", "text": "No significant differences were found for intensive care unit mortality ( @ patients with BiPAP -LSB- @ % -RSB- and @ with high-flow nasal oxygen therapy -LSB- @ % -RSB- ; P = @ ) ( absolute difference , @ % -LSB- @ % CI , -@ % to @ % -RSB- .", "sentence_id": 10}
+{"abstract_id": "25980660", "label": "results", "text": "Skin breakdown was significantly more common with BiPAP after @ hours ( @ % vs @ % ; @ % CI , @ % -@ % vs @ % -@ % ; P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25980660", "label": "conclusions", "text": "Among cardiothoracic surgery patients with or at risk for respiratory failure , the use of high-flow nasal oxygen therapy compared with intermittent BiPAP did not result in a worse rate of treatment failure .", "sentence_id": 12}
+{"abstract_id": "25980660", "label": "conclusions", "text": "The findings support the use of high-flow nasal oxygen therapy in similar patients .", "sentence_id": 13}
+{"abstract_id": "25880068", "label": "background", "text": "Treatment for hypertension with antihypertensive medication has been shown to reduce stroke , cardiovascular events , and mortality in older adults , but there is concern that such treatment may not be appropriate in frailer older adults .", "sentence_id": 0}
+{"abstract_id": "25880068", "label": "background", "text": "To investigate whether there is an interaction between effect of treatment for hypertension and frailty in older adults , we calculated the frailty index ( FI ) for all available participants from the HYpertension in the Very Elderly Trial ( HYVET ) study , a double-blind , placebo-controlled study of antihypertensives in people with hypertension aged @ and over , and obtained frailty adjusted estimates of the effect of treatment with antihypertensive medication on risk of stroke , cardiovascular events , and mortality .", "sentence_id": 1}
+{"abstract_id": "25880068", "label": "methods", "text": "Participants in HYVET were randomised @:@ to active treatment with indapamide sustained release @ mgperindopril @ to @mg or to matching placebo .", "sentence_id": 2}
+{"abstract_id": "25880068", "label": "methods", "text": "Data relating to blood pressure , comorbidities , cognitive function , depression , and quality of life were collected at entry into the study and at subsequent follow-up visits .", "sentence_id": 3}
+{"abstract_id": "25880068", "label": "methods", "text": "The FI was calculated at entry , based on @ potential deficits .", "sentence_id": 4}
+{"abstract_id": "25880068", "label": "methods", "text": "The distribution of FI was similar to that seen in population studies of adults aged @years and above ( median FI , @ ; IQR , @-@ @ ) .", "sentence_id": 5}
+{"abstract_id": "25880068", "label": "methods", "text": "Cox regression was used to assess the impact of FI at entry to the study on subsequent risk of stroke , total mortality , and cardiovascular events .", "sentence_id": 6}
+{"abstract_id": "25880068", "label": "methods", "text": "Models were stratified by region of recruitment and adjusted for sex and age at entry .", "sentence_id": 7}
+{"abstract_id": "25880068", "label": "methods", "text": "Extending these models to include a term for a possible interaction between treatment for hypertension and FI provided a formula for the treatment effect as a function of FI .", "sentence_id": 8}
+{"abstract_id": "25880068", "label": "methods", "text": "For all three models , the point estimates of the hazard ratios for the treatment effect decreased as FI increased , although to varying degrees and with varying certainty .", "sentence_id": 9}
+{"abstract_id": "25880068", "label": "results", "text": "We found no evidence of an interaction between effect of treatment for hypertension and frailty as measured by the FI .", "sentence_id": 10}
+{"abstract_id": "25880068", "label": "results", "text": "Both the frailer and the fitter older adults with hypertension appeared to gain from treatment .", "sentence_id": 11}
+{"abstract_id": "25880068", "label": "conclusions", "text": "Further work to examine whether antihypertensive treatment modifies frailty as measured by the FI should be explored .", "sentence_id": 12}
+{"abstract_id": "24382088", "label": "background", "text": "The IAPT services provide high and low intensity psychological treatments for adults suffering from depression and anxiety disorders using a stepped care model .", "sentence_id": 0}
+{"abstract_id": "24382088", "label": "background", "text": "The latest national evaluation study reported an average recovery rate of @ % .", "sentence_id": 1}
+{"abstract_id": "24382088", "label": "background", "text": "However , this figure varied widely between services , with better outcomes associated with higher `` step-up '' rates between low and high intensity treatments .", "sentence_id": 2}
+{"abstract_id": "24382088", "label": "objective", "text": "This study aimed to compare the two intensity groups in an IAPT service in Suffolk .", "sentence_id": 3}
+{"abstract_id": "24382088", "label": "methods", "text": "This study adopted a between groups design .", "sentence_id": 4}
+{"abstract_id": "24382088", "label": "methods", "text": "A sample of @ service users was randomly selected from the data collected from an IAPT service in Suffolk between May @ and February @ .", "sentence_id": 5}
+{"abstract_id": "24382088", "label": "methods", "text": "The treatment outcomes , drop-out rate , and other characteristics were compared between those who received high and low intensity treatments .", "sentence_id": 6}
+{"abstract_id": "24382088", "label": "results", "text": "The high intensity group received , on average , more sessions and contact time .", "sentence_id": 7}
+{"abstract_id": "24382088", "label": "results", "text": "They received more CBT sessions and less guided self-help .", "sentence_id": 8}
+{"abstract_id": "24382088", "label": "results", "text": "There were no group differences in terms of the drop-out and appointment cancellation rates .", "sentence_id": 9}
+{"abstract_id": "24382088", "label": "results", "text": "Analyses on clinical outcomes suggested no group difference but demonstrated an overall recovery rate of @ % and significant reduction in both depression and anxiety symptoms .", "sentence_id": 10}
+{"abstract_id": "24382088", "label": "conclusions", "text": "Despite methodological limitations , this study concludes that the service as a whole achieved above-average clinical outcomes .", "sentence_id": 11}
+{"abstract_id": "24382088", "label": "conclusions", "text": "Further research building upon the current study in unpacking the relative strengths and weaknesses for the high and low intensity treatments would be beneficial for service delivery .", "sentence_id": 12}
+{"abstract_id": "25410607", "label": "background", "text": "Falling in older age is a serious and costly problem .", "sentence_id": 0}
+{"abstract_id": "25410607", "label": "background", "text": "At least one in three older people fall annually .", "sentence_id": 1}
+{"abstract_id": "25410607", "label": "background", "text": "Although exercise is recognised as an effective fall prevention intervention , low numbers of older people engage in suitable programmes .", "sentence_id": 2}
+{"abstract_id": "25410607", "label": "background", "text": "Health and exercise professionals play a crucial role in addressing fall risk in older adults .", "sentence_id": 3}
+{"abstract_id": "25410607", "label": "background", "text": "This trial aims to evaluate the effect of participation in a fall prevention educational programme , compared with a wait-list control group , on health and exercise professionals ' knowledge about fall prevention and the effect on fall prevention exercise prescription behaviour and confidence to prescribe the exercises to older people .", "sentence_id": 4}
+{"abstract_id": "25410607", "label": "methods", "text": "A randomised controlled trial involving @ consenting health and exercise professionals will be conducted .", "sentence_id": 5}
+{"abstract_id": "25410607", "label": "methods", "text": "Participants will be individually randomised to an intervention group ( n = @ ) to receive an educational workshop plus access to internet-based support resources , or a wait-list control group ( n = @ ) .", "sentence_id": 6}
+{"abstract_id": "25410607", "label": "methods", "text": "The two primary outcomes , measured @months after randomisation , are : ( @ ) knowledge about fall prevention and ( @ ) self-perceived change in fall prevention exercise prescription behaviour .", "sentence_id": 7}
+{"abstract_id": "25410607", "label": "methods", "text": "Secondary outcomes include : ( @ ) participants ' confidence to prescribe fall prevention exercises ; ( @ ) the proportion of people aged @ + years seen by trial participants in the past month who were prescribed fall prevention exercise ; and ( @ ) the proportion of fall prevention exercises prescribed by participants to older people in the past month that comply with evidence-based guidelines .", "sentence_id": 8}
+{"abstract_id": "25410607", "label": "methods", "text": "Outcomes will be measured with a self-report questionnaire designed specifically for the trial .", "sentence_id": 9}
+{"abstract_id": "25527255", "label": "background", "text": "Diabetes self-management often involves the interpretation and application of oral , written , or quantitative information .", "sentence_id": 0}
+{"abstract_id": "25527255", "label": "background", "text": "Numerous diabetes patients in China have limited health literacy , which likely leads to poorer clinical outcomes .", "sentence_id": 1}
+{"abstract_id": "25527255", "label": "background", "text": "This study is designed to examine the efficacy and cost-effectiveness of addressing health literacy to improve self-management skills and glycemic control in Chinese diabetes patients .", "sentence_id": 2}
+{"abstract_id": "25527255", "label": "methods", "text": "This is a cluster randomized controlled trial ( RCT ) conducted in @ community healthcare sites in Shanghai , China .", "sentence_id": 3}
+{"abstract_id": "25527255", "label": "methods", "text": "Overall , @ diabetes patients will be randomized into intervention and control arms and will have a baseline hemoglobin A@c ( HbA@c ) assay and undergo a baseline survey which includes measures of health literacy and diabetes numeracy using revised Chinese versions of the Health Literacy Management Scale and Diabetes Numeracy Test Scale .", "sentence_id": 4}
+{"abstract_id": "25527255", "label": "methods", "text": "During the @-year period of intervention , while the control group will receive usual care , the intervention group will be supplemented with a comprehensive health literacy strategy which includes i ) training healthcare providers in effective health communication skills that address issues related to low literacy , and ii ) use of an interactive Diabetes Education Toolkit to improve patient understanding and behaviors .", "sentence_id": 5}
+{"abstract_id": "25527255", "label": "methods", "text": "Assessments will be conducted at both patient and healthcare provider levels , and will take place upon admission and after @ , @ , @ , and @ months of intervention .", "sentence_id": 6}
+{"abstract_id": "25527255", "label": "methods", "text": "The primary outcome will be the improvement in HbA@c between Intervention group and Control group patients .", "sentence_id": 7}
+{"abstract_id": "25527255", "label": "methods", "text": "Secondary outcomes at the patient level will include improvement in i ) clinical outcomes ( blood pressure , fasting lipids , body mass index , weight , smoking status ) , ii ) patient reported self-management behaviors , and iii ) patient-reported self-efficacy .", "sentence_id": 8}
+{"abstract_id": "25527255", "label": "methods", "text": "Outcomes at the provider level will include : i ) provider satisfaction and ii ) intensity and type of care provided .", "sentence_id": 9}
+{"abstract_id": "25527255", "label": "methods", "text": "The effects of the intervention will be examined in multivariable general linear models .", "sentence_id": 10}
+{"abstract_id": "25527255", "label": "methods", "text": "Both cost-effectiveness and cost-utility analyses will be performed .", "sentence_id": 11}
+{"abstract_id": "25527255", "label": "conclusions", "text": "The main strengths of this study are its large sample size and RCT design , involvement of both patients and healthcare providers , and the long term follow-up ( @-months ) .", "sentence_id": 12}
+{"abstract_id": "25527255", "label": "conclusions", "text": "This project will help to demonstrate the value of addressing health literacy and health communication to improve self-management and clinical outcomes among Chinese diabetes patients .", "sentence_id": 13}
+{"abstract_id": "25248446", "label": "background", "text": "The patients with brain lesion have a high risk of pulmonary complication due to restrictive pulmonary impairment .", "sentence_id": 0}
+{"abstract_id": "25248446", "label": "objective", "text": "To investigate the effectiveness of active pulmonary rehabilitation on pulmonary functional improvement in these patients .", "sentence_id": 1}
+{"abstract_id": "25248446", "label": "methods", "text": "Twnety-two patients of hemiplegia or quadriplegia with brain lesion were recruited who had restrictive pulmonary impairment .", "sentence_id": 2}
+{"abstract_id": "25248446", "label": "methods", "text": "The patients were randomly assigned to an experimental group that receive active pulmonary rehabilitation training and a control group without it .", "sentence_id": 3}
+{"abstract_id": "25248446", "label": "methods", "text": "The active pulmonary rehabilitation training is composed of air-stacking exercise by ambu-bagging and functional electrical stimulation ( FES ) on phrenic nerve and abdominal muscle .", "sentence_id": 4}
+{"abstract_id": "25248446", "label": "methods", "text": "We examined respiration function test of all patients composed of peak cough flow ( PCF ) , pulmonary function test ( PFT ) , diaphragmatic motion evaluation and oxygen saturation ( SaO@ ) at the beginning and @ weeks after treatment .", "sentence_id": 5}
+{"abstract_id": "25248446", "label": "results", "text": "There was no significant difference in pulmonary function between experimental group and control group at the beginning .", "sentence_id": 6}
+{"abstract_id": "25248446", "label": "results", "text": "After @ weeks treatment , FVC and FEV@ of PFT , PCF , diaphragmatic motion , SaO@ have significantly improved ( p < @ ) in experimental group , but no significant changes were detected in control group .", "sentence_id": 7}
+{"abstract_id": "25248446", "label": "conclusions", "text": "It is suggested that active pulmonary rehabilitation with air-stacking exercise and FES would be useful to improve pulmonary function in patients with brain lesion .", "sentence_id": 8}
+{"abstract_id": "25308309", "label": "objective", "text": "The observation of movements increases primary motor cortex ( M@ ) excitability .", "sentence_id": 0}
+{"abstract_id": "25308309", "label": "objective", "text": "This exploratory study examined the effects of movement observation on pressure pain threshold ( PPT ) and transcranial magnetic stimulation ( TMS ) - indexed corticospinal excitability bilaterally .", "sentence_id": 1}
+{"abstract_id": "25308309", "label": "methods", "text": "Thirty healthy right-handed subjects were randomized to a left hand-movement observation task or a control task .", "sentence_id": 2}
+{"abstract_id": "25308309", "label": "methods", "text": "Statistical analyses were performed using ANOVA models and t-tests .", "sentence_id": 3}
+{"abstract_id": "25308309", "label": "methods", "text": "Results were not corrected for multiple comparisons .", "sentence_id": 4}
+{"abstract_id": "25308309", "label": "methods", "text": "Quantitative sensory assessments were measured in both hands , while M@ excitability has only been tested for the right ( non-dominant ) M@ corresponding to the observed left hand movements .", "sentence_id": 5}
+{"abstract_id": "25308309", "label": "results", "text": "Analysis of pain and cortical silent period ( CSP ) outcomes demonstrated a significant interaction between task ( hand-movement group ) versus control group and time ( pre - / postintervention ) .", "sentence_id": 6}
+{"abstract_id": "25308309", "label": "results", "text": "PPT increased in the left hand ( moving hand in the task ) and declined significantly in the contralateral hand ( still hand ) in the movement-observation-task-group , whereas PTT in the control group remained unchanged .", "sentence_id": 7}
+{"abstract_id": "25308309", "label": "results", "text": "CSP was significantly shorter in the movement-observation group indicating decreased intracortical inhibition ( results uncorrected for multiple comparisons ) .", "sentence_id": 8}
+{"abstract_id": "25308309", "label": "conclusions", "text": "The observation of hand-movements led to a side-specific reduction in pain perception and a decrease in intracortical inhibition .", "sentence_id": 9}
+{"abstract_id": "25308309", "label": "conclusions", "text": "These exploratory findings support the notion that M@ is a robust modulator of pain-related neural networks .", "sentence_id": 10}
+{"abstract_id": "25308309", "label": "conclusions", "text": "This effect might be mediated through modulation of the GABAergic system and appears to differ from what is observed in chronic pain .", "sentence_id": 11}
+{"abstract_id": "25146059", "label": "background", "text": "This study explored the effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy .", "sentence_id": 0}
+{"abstract_id": "25146059", "label": "methods", "text": "For this experimental study , @ subjects were randomly assigned to three groups : acupressure with essential oils ( n = @ ) , acupressure only ( n = @ ) , and sham acupressure ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25146059", "label": "methods", "text": "Acupoints were Hegu ( LI@ ) , Zusanli ( ST@ ) , and Sanyingjiao ( SP@ ) .", "sentence_id": 2}
+{"abstract_id": "25146059", "label": "methods", "text": "All subjects received acupressure once every morning for @ months , with each acupoint pressed for @ min .", "sentence_id": 3}
+{"abstract_id": "25146059", "label": "methods", "text": "Fatigue , functional status , anxiety , depression , and sleep quality were measured before initial chemotherapy ( T@ ) , on Day @ of third chemotherapy ( T@ ) , and on Day @ of sixth chemotherapy ( T@ ) .", "sentence_id": 4}
+{"abstract_id": "25146059", "label": "methods", "text": "Outcome differences between groups were analyzed at T@ , T@ , and T@ by general estimating equations .", "sentence_id": 5}
+{"abstract_id": "25146059", "label": "results", "text": "After controlling for baseline outcome values , age , and adherence to acupressure , subjects who received acupressure with essential oils and acupressure had significantly less fatigue in daily living activities and sleep better quality at T@ than subjects who received sham acupressure .", "sentence_id": 6}
+{"abstract_id": "25146059", "label": "results", "text": "Subjects who received acupressure with essential oils had significantly better sleep quality at T@ than the sham acupressure group .", "sentence_id": 7}
+{"abstract_id": "25146059", "label": "results", "text": "Subjects who received acupressure with or without essential oils had greater odds of better functional status at T@ than the sham group .", "sentence_id": 8}
+{"abstract_id": "25146059", "label": "conclusions", "text": "It is plausible that acupressure with or without essential oils helps lung cancer patients undergoing chemotherapy reduce cancer-related fatigue and increase activity level .", "sentence_id": 9}
+{"abstract_id": "25146059", "label": "conclusions", "text": "Further study is wanted to test this hypothesis .", "sentence_id": 10}
+{"abstract_id": "24901838", "label": "objective", "text": "`` Outlet obstruction '' is a complex functional disorder compelling patients to exhausting uneffective attempts to void .", "sentence_id": 0}
+{"abstract_id": "24901838", "label": "objective", "text": "This study was designed to compare the effectiveness and a safety of the endorectal proctopexy ( internal Delorme ) vs STARR procedure in two groups of patients .", "sentence_id": 1}
+{"abstract_id": "24901838", "label": "methods", "text": "A total of @ patients with rectocele and associated mucosal prolapse or anorectal intussusception between January @ and June @ were randomly assigned to Group # @ Endorectal proctopexy with levatorplasty ( ERPP ) and Group # @ STARR .", "sentence_id": 2}
+{"abstract_id": "24901838", "label": "methods", "text": "Patients were assessed one week , six and twelve months after the operation .", "sentence_id": 3}
+{"abstract_id": "24901838", "label": "methods", "text": "Operative time , postoperative pain , day of discharge and late complications was recorded .", "sentence_id": 4}
+{"abstract_id": "24901838", "label": "methods", "text": "The time of recovery of work was also assessed .", "sentence_id": 5}
+{"abstract_id": "24901838", "label": "methods", "text": "The continence score was updated with a constipation questionnaire .", "sentence_id": 6}
+{"abstract_id": "24901838", "label": "methods", "text": "Quality of life after the operation and the overall grade of satisfaction were assessed and compared with radiological findings .", "sentence_id": 7}
+{"abstract_id": "24901838", "label": "methods", "text": "All patients were reassessed after one year .", "sentence_id": 8}
+{"abstract_id": "24901838", "label": "results", "text": "The results in the two groups of patients show no significant difference between ERPP and STARR : the improvement in symptoms is similar but significant and well definite in both groups with a low incidence of postoperative complications .", "sentence_id": 9}
+{"abstract_id": "24901838", "label": "results", "text": "STARR procedure is just faster to perform even if more expensive .", "sentence_id": 10}
+{"abstract_id": "24901838", "label": "results", "text": "Dyspareunia slightly improved mainly in ERPP group , due probably to scar distention .", "sentence_id": 11}
+{"abstract_id": "24901838", "label": "conclusions", "text": "The results of our experience indicate a significant improvement of symptoms with both techniques .", "sentence_id": 12}
+{"abstract_id": "24901838", "label": "conclusions", "text": "The overall incidence rate of postoperative complications is low and similar between the two groups .", "sentence_id": 13}
+{"abstract_id": "24901838", "label": "conclusions", "text": "As economical consideration , ERPP is less expensive .", "sentence_id": 14}
+{"abstract_id": "26008626", "label": "objective", "text": "To study the effect of different protocols of collagen cross-linking on visual , refractive , and tomographic parameters in patients with progressive keratoconus .", "sentence_id": 0}
+{"abstract_id": "26008626", "label": "methods", "text": "Prospective randomized interventional study .", "sentence_id": 1}
+{"abstract_id": "26008626", "label": "methods", "text": "In this study , @ eyes of @ patients with progressive keratoconus underwent corneal collagen cross-linking ( CXL ) .", "sentence_id": 2}
+{"abstract_id": "26008626", "label": "methods", "text": "Following detailed preoperative examination , Group I underwent conventional cross-linking ( @ patients , @ mW/cm ( @ ) for @ min ) ; Group II ( @ patients , @ mW/cm ( @ ) for @ min ) , Group III ( @ patients , @ mW/cm ( @ ) for @ min ) , and Group IV ( @ patients , @ mW/cm ( @ ) for @ min ) underwent accelerated cross-linking .", "sentence_id": 3}
+{"abstract_id": "26008626", "label": "methods", "text": "Changes in corrected distance visual acuity ( CDVA ) , spherical equivalent ( SE ) , flat keratometry , steep keratometry , thinnest pachymetry , specular microscopy , and demarcation line were studied at @ and @ months .", "sentence_id": 4}
+{"abstract_id": "26008626", "label": "results", "text": "Improvement in the mean CDVA and SE were statistically significant in all groups except Group IV ( P = @ at @ months , P = @ at @ months ) , with Group III ( P = @ at @ and @ months ) showing the best results .", "sentence_id": 5}
+{"abstract_id": "26008626", "label": "results", "text": "Flattening of steep and flat keratometry was significant in Groups I ( P = @ ) and II ( P = @ ) as compared to the other groups .", "sentence_id": 6}
+{"abstract_id": "26008626", "label": "results", "text": "There was no significant difference in the pachymetry or specular microscopy in any of the groups .", "sentence_id": 7}
+{"abstract_id": "26008626", "label": "results", "text": "Groups I and II demonstrated a good demarcation line when compared to other groups .", "sentence_id": 8}
+{"abstract_id": "26008626", "label": "conclusions", "text": "Conventional CXL ( Group I ) and accelerated CXL with irradiations of @ mW/cm ( @ ) ( Group II ) and @ mW/cm ( @ ) ( Group III ) showed better visual , refractive , and tomographic improvements at the end of @ months .", "sentence_id": 9}
+{"abstract_id": "25072937", "label": "background", "text": "Arginase competes with nitric oxide synthase for their common substrate L-arginine .", "sentence_id": 0}
+{"abstract_id": "25072937", "label": "background", "text": "Up-regulation of arginase in coronary artery disease ( CAD ) and diabetes mellitus may reduce nitric oxide bioavailability contributing to endothelial dysfunction and ischemia-reperfusion injury .", "sentence_id": 1}
+{"abstract_id": "25072937", "label": "background", "text": "Arginase inhibition reduces infarct size in animal models .", "sentence_id": 2}
+{"abstract_id": "25072937", "label": "background", "text": "Therefore the aim of the current study was to investigate if arginase inhibition protects from endothelial dysfunction induced by ischemia-reperfusion in patients with CAD with or without type @ diabetes (", "sentence_id": 3}
+{"abstract_id": "25072937", "label": "background", "text": "NCT@ ) .", "sentence_id": 4}
+{"abstract_id": "25072937", "label": "methods", "text": "Male patients with CAD ( n = @ ) or CAD + type @ diabetes ( n = @ ) , were included in this cross-over study with blinded evaluation .", "sentence_id": 5}
+{"abstract_id": "25072937", "label": "methods", "text": "Endothelium-dependent vasodilatation was assessed by flow-mediated dilatation ( FMD ) of the radial artery before and after @ min ischemia-reperfusion during intra-arterial infusion of the arginase inhibitor ( N-hydroxy-nor-L-arginine , @ mg/min ) or saline .", "sentence_id": 6}
+{"abstract_id": "25072937", "label": "results", "text": "The forearm ischemia-reperfusion was well tolerated .", "sentence_id": 7}
+{"abstract_id": "25072937", "label": "results", "text": "Endothelium-independent vasodilatation was assessed by sublingual nitroglycerin .", "sentence_id": 8}
+{"abstract_id": "25072937", "label": "results", "text": "Ischemia-reperfusion decreased FMD in patients with CAD from @ % to @ % during saline administration ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25072937", "label": "results", "text": "N-hydroxy-nor-L-arginine administration prevented the decrease in FMD in the CAD group ( @ % at baseline vs. @ % at reperfusion ) .", "sentence_id": 10}
+{"abstract_id": "25072937", "label": "results", "text": "Ischemia-reperfusion did not significantly reduce FMD in patients with CAD + type @ diabetes .", "sentence_id": 11}
+{"abstract_id": "25072937", "label": "results", "text": "However , FMD at reperfusion was higher following nor-NOHA than following saline administration in both groups ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25072937", "label": "results", "text": "Endothelium-independent vasodilatation did not differ between the occasions .", "sentence_id": 13}
+{"abstract_id": "25072937", "label": "conclusions", "text": "Inhibition of arginase protects against endothelial dysfunction caused by ischemia-reperfusion in patients with CAD .", "sentence_id": 14}
+{"abstract_id": "25072937", "label": "conclusions", "text": "Arginase inhibition may thereby be a promising therapeutic strategy in the treatment of ischemia-reperfusion injury .", "sentence_id": 15}
+{"abstract_id": "24930639", "label": "objective", "text": "To evaluate the clinical and microbiological effects of the use of metronidazole ( MTZ ) + amoxicillin ( AMX ) as adjuncts to scaling and root planing ( SRP ) for the treatment of chronic periodontitis ( ChP ) in type @ diabetic subjects .", "sentence_id": 0}
+{"abstract_id": "24930639", "label": "methods", "text": "Fifty-eight type @ diabetic subjects ( n = @/group ) with generalized ChP were randomly assigned to receive SRP alone or with MTZ -LSB- @mg/thrice a day ( TID ) -RSB- + AMX ( @mg/TID ) for @days .", "sentence_id": 1}
+{"abstract_id": "24930639", "label": "methods", "text": "Subgingival biofilm samples were analyzed by qPCR for the presence of seven periodontal pathogens .", "sentence_id": 2}
+{"abstract_id": "24930639", "label": "methods", "text": "Subjects were monitored at baseline , @ , @ and @months post-therapies .", "sentence_id": 3}
+{"abstract_id": "24930639", "label": "results", "text": "The group receiving SRP+MTZ+AMX presented greater mean probing depth ( PD ) reduction and clinical attachment gain , a lower number of sites with PD @mm ( primary outcome variable ) and a reduced number of subjects with @ of these residual pockets than the control group at @-year post-therapy ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24930639", "label": "results", "text": "The antibiotic-treated group also presented reduced levels and greater decreases of the three red complex species , Eubacterium nodatum and Prevotella intermedia , compared to the control group at @year ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24930639", "label": "conclusions", "text": "The adjunctive use of MTZ+AMX significantly improved the clinical and microbiological outcomes of SRP in the treatment of type @ diabetic subjects with ChP .", "sentence_id": 6}
+{"abstract_id": "24245844", "label": "objective", "text": "To evaluate an intervention based on implementation intention principles designed to increase uptake of colorectal cancer screening , and to examine differential efficacy by socioeconomic deprivation .", "sentence_id": 0}
+{"abstract_id": "24245844", "label": "methods", "text": "In England , adults aged between @ and @ years are invited for biennial fecal occult blood testing .", "sentence_id": 1}
+{"abstract_id": "24245844", "label": "methods", "text": "A test kit and an information leaflet are mailed to each individual by the `` Hubs '' that deliver the national screening program .", "sentence_id": 2}
+{"abstract_id": "24245844", "label": "methods", "text": "In the intervention group , three preformulated implementation intentions , based on known barriers to carrying out the test , were added to the information leaflet .", "sentence_id": 3}
+{"abstract_id": "24245844", "label": "methods", "text": "Over a @-week period , each week was randomly allocated to either the intervention ( n = @,@ invitations ) or the control condition ( n = @,@ ) , with uptake recorded at the Hub .", "sentence_id": 4}
+{"abstract_id": "24245844", "label": "methods", "text": "Socioeconomic deprivation of each individual 's area of residence was categorized into tertiles .", "sentence_id": 5}
+{"abstract_id": "24245844", "label": "results", "text": "There was no overall difference in uptake between control ( @ % ) and intervention ( @ % ) conditions , odds ratio ( OR ) = @ , @ % confidence interval ( CI ) -LSB- @ , @ -RSB- .", "sentence_id": 6}
+{"abstract_id": "24245844", "label": "results", "text": "There was an interaction with deprivation , OR = @ , @ % CI -LSB- @ , @ -RSB- , but the positive effect observed in the lowest socioeconomic status ( SES ) tertile was small ( @ % vs. @ % ) , OR = @ , @ % CI -LSB- @ , @ -RSB- , and offset by a negative effect in the least deprived tertile ( @ % vs. @ % ) , OR = @ , @ % CI -LSB- @ , @ -RSB- .", "sentence_id": 7}
+{"abstract_id": "24245844", "label": "results", "text": "The intervention had no significant effect in the middle tertile ( @ % vs. @ % ) , OR = @ , @ % CI -LSB- @ , @ -RSB- .", "sentence_id": 8}
+{"abstract_id": "24245844", "label": "conclusions", "text": "Preformulated implementation intentions did not increase overall colorectal cancer screening uptake and failed to make a sufficiently large impact on uptake among lower SES groups to merit their future use in this context .", "sentence_id": 9}
+{"abstract_id": "25209738", "label": "background", "text": "Duchenne muscular dystrophy is caused by dystrophin deficiency and muscle deterioration and preferentially affects boys .", "sentence_id": 0}
+{"abstract_id": "25209738", "label": "background", "text": "Antisense-oligonucleotide-induced exon skipping allows synthesis of partially functional dystrophin .", "sentence_id": 1}
+{"abstract_id": "25209738", "label": "background", "text": "We investigated the efficacy and safety of drisapersen , a @ ' - O-methyl-phosphorothioate antisense oligonucleotide , given for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25209738", "label": "methods", "text": "In this exploratory , double-blind , placebo-controlled study we recruited male patients ( @ years of age ; time to rise from floor @ s ) with Duchenne muscular dystrophy from @ specialist centres in nine countries between Sept @ , @ , and Sept @ , @ .", "sentence_id": 3}
+{"abstract_id": "25209738", "label": "methods", "text": "By use of a computer-generated randomisation sequence , we randomly allocated patients ( @:@:@:@ ; block size of six ; no stratification ) to drisapersen @ mg/kg or placebo , each given subcutaneously and either continuously ( once weekly ) or intermittently ( nine doses over @ weeks ) .", "sentence_id": 4}
+{"abstract_id": "25209738", "label": "methods", "text": "The primary endpoint was change in @-min walk distance ( @MWD ) at week @ in patients in the intention-to-treat population for whom data were available .", "sentence_id": 5}
+{"abstract_id": "25209738", "label": "methods", "text": "Safety assessments included renal , hepatic , and haematological monitoring and recording of adverse events .", "sentence_id": 6}
+{"abstract_id": "25209738", "label": "methods", "text": "This trial is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 7}
+{"abstract_id": "25209738", "label": "results", "text": "We recruited @ patients : @ were given continuous drisapersen , @ were given intermittent drisapersen , and @ were given placebo ( continuous and intermittent groups combined ) .", "sentence_id": 8}
+{"abstract_id": "25209738", "label": "results", "text": "At week @ , mean @MWD had increased by @ m ( SE @ ) from baseline for continuous drisapersen , with a mean difference in change from baseline of @ m ( @ % CI @ to @ ; p = @ ) versus placebo .", "sentence_id": 9}
+{"abstract_id": "25209738", "label": "results", "text": "We recorded no difference in @MWD changes from baseline between intermittent drisapersen ( mean change -@ -LSB- SE @ -RSB- ) and placebo ( mean difference @ m -LSB- -@ to @ -RSB- ) at week @ .", "sentence_id": 10}
+{"abstract_id": "25209738", "label": "results", "text": "The most common adverse events in drisapersen-treated patients were injection-site reactions ( @ patients given continuous drisapersen , @ patients given intermittent drisapersen , and six given placebo ) and renal events ( @ for continuous drisapersen , @ for intermittent drisapersen , and seven for placebo ) , most of which were subclinical proteinuria .", "sentence_id": 11}
+{"abstract_id": "25209738", "label": "results", "text": "None of the serious adverse events reported ( one for continuous , two for intermittent , and two for placebo ) resulted in withdrawal from the study .", "sentence_id": 12}
+{"abstract_id": "25209738", "label": "conclusions", "text": "Continuous drisapersen resulted in some benefit in @MWD versus placebo at week @ .", "sentence_id": 13}
+{"abstract_id": "25209738", "label": "conclusions", "text": "The safety findings are similar to those from previous studies .", "sentence_id": 14}
+{"abstract_id": "25209738", "label": "conclusions", "text": "Ambulation improvements in this young population with early-stage Duchenne muscular dystrophy are encouraging but need to be confirmed in larger studies .", "sentence_id": 15}
+{"abstract_id": "24569536", "label": "objective", "text": "Evidence from animal and in vitro models suggest a role of probiotic bacteria in improving glycaemic control and delaying the onset of type @ diabetes .", "sentence_id": 0}
+{"abstract_id": "24569536", "label": "objective", "text": "However , the evidence from controlled trials in humans is limited .", "sentence_id": 1}
+{"abstract_id": "24569536", "label": "objective", "text": "The objective was to determine if the probiotic bacteria L. acidophilus La@ and B. animalis subsp lactis Bb@ , supplemented in a whole food ( yoghurt ) or isolated ( capsules ) form , can improve biomarkers of glycaemic control .", "sentence_id": 2}
+{"abstract_id": "24569536", "label": "methods", "text": "Following a @-week washout period , @ overweight men and women over @ years ( mean age : @ @ years ; mean body mass index ( @ @ kg/m ( @ ) ) were randomized to a @-week double-blinded parallel study .", "sentence_id": 3}
+{"abstract_id": "24569536", "label": "methods", "text": "The four intervention groups were : ( A ) probiotic yoghurt plus probiotic capsules ; ( B ) probiotic yoghurt plus placebo capsules ; ( C ) control milk plus probiotic capsules ; and ( D ) control milk plus placebo capsules .", "sentence_id": 4}
+{"abstract_id": "24569536", "label": "methods", "text": "Outcome measurements , including fasting glucose , insulin , glycated haemoglobin and Homoeostasis Model Assessment of Insulin Resistance ( HOMA-IR ) , were performed at baseline and week @ .", "sentence_id": 5}
+{"abstract_id": "24569536", "label": "results", "text": "Relative to the milk-control group , probiotic yoghurt resulted in a significantly higher HOMA-IR ( @ @ , P = @ ) , but did not have a significant effect on the other three measures of glycaemic control ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24569536", "label": "results", "text": "Relative to placebo capsules , probiotic capsules resulted in a significantly higher fasting glucose ( @ @ mmol/l , P = @ ) , with no significant effect on the other three measures of glycaemic control ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24569536", "label": "results", "text": "Further analyses did not identify other variables as contributing to these adverse findings .", "sentence_id": 8}
+{"abstract_id": "24569536", "label": "conclusions", "text": "Data from this study does not support the hypothesis that L. acidophilus La@ and B. animalis subsp lactis Bb@ , either in isolated form or as part of a whole food , benefit short-term glycaemic control .", "sentence_id": 9}
+{"abstract_id": "24569536", "label": "conclusions", "text": "Indeed , there is weak data for an adverse effect of these strains on glucose homoeostasis .", "sentence_id": 10}
+{"abstract_id": "25660917", "label": "background", "text": "People who are physically active have at least a @ % lower risk of death during follow-up compared with those who are inactive .", "sentence_id": 0}
+{"abstract_id": "25660917", "label": "background", "text": "However , the ideal dose of exercise for improving longevity is uncertain .", "sentence_id": 1}
+{"abstract_id": "25660917", "label": "objective", "text": "The aim of this study was to investigate the association between jogging and long-term , all-cause mortality by focusing specifically on the effects of pace , quantity , and frequency of jogging .", "sentence_id": 2}
+{"abstract_id": "25660917", "label": "methods", "text": "As part of the Copenhagen City Heart Study , @,@ healthy joggers and @,@ healthy nonjoggers have been prospectively followed up since @ .", "sentence_id": 3}
+{"abstract_id": "25660917", "label": "methods", "text": "Cox proportional hazards regression analysis was performed with age as the underlying time scale and delayed entry .", "sentence_id": 4}
+{"abstract_id": "25660917", "label": "results", "text": "Compared with sedentary nonjoggers , @ to @ h of jogging per week was associated with the lowest mortality ( multivariable hazard ratio -LSB- HR -RSB- : @ ; @ % confidence interval -LSB- CI -RSB- : @ to @ ) .", "sentence_id": 5}
+{"abstract_id": "25660917", "label": "results", "text": "The optimal frequency of jogging was @ to @ times per week ( HR : @ ; @ % CI : @ to @ ) or @ time per week ( HR : @ ; @ % CI : @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "25660917", "label": "results", "text": "The optimal pace was slow ( HR : @ ; @ % CI : @ to @ ) or average ( HR : @ ; @ % CI : @ to @ ) .", "sentence_id": 7}
+{"abstract_id": "25660917", "label": "results", "text": "The joggers were divided into light , moderate , and strenuous joggers .", "sentence_id": 8}
+{"abstract_id": "25660917", "label": "results", "text": "The lowest HR for mortality was found in light joggers ( HR : @ ; @ % CI : @ to @ ) , followed by moderate joggers ( HR : @ ; @ % CI : @ to @ ) and strenuous joggers ( HR : @ ; @ % CI : @ to @ ) .", "sentence_id": 9}
+{"abstract_id": "25660917", "label": "conclusions", "text": "The findings suggest a U-shaped association between all-cause mortality and dose of jogging as calibrated by pace , quantity , and frequency of jogging .", "sentence_id": 10}
+{"abstract_id": "25660917", "label": "conclusions", "text": "Light and moderate joggers have lower mortality than sedentary nonjoggers , whereas strenuous joggers have a mortality rate not statistically different from that of the sedentary group .", "sentence_id": 11}
+{"abstract_id": "25158846", "label": "background", "text": "In August @ , the Federal Joint Committee ( G-BA ) decided that negative pressure wound therapy ( NPWT ) would not be reimbursable in German ambulatory care .", "sentence_id": 0}
+{"abstract_id": "25158846", "label": "background", "text": "This decision was based on reports from the Institute for Quality and Efficiency in Health Care ( IQWiG ) , which concluded that there is no convincing evidence in favor of NPWT .", "sentence_id": 1}
+{"abstract_id": "25158846", "label": "background", "text": "The aim of this diabetic foot study ( DiaFu study ) is to evaluate whether the clinical , safety and economic results of NPWT are superior to the results of standard wound treatment .", "sentence_id": 2}
+{"abstract_id": "25158846", "label": "methods", "text": "The DiaFu study is designed as a national , multicenter , randomized controlled clinical superiority trial with a special focus on outpatient care in Germany .", "sentence_id": 3}
+{"abstract_id": "25158846", "label": "methods", "text": "Competent patients in inpatient and outpatient care suffering from a chronic diabetic foot wound for a minimum of four weeks may be included in the study .", "sentence_id": 4}
+{"abstract_id": "25158846", "label": "methods", "text": "The trial evaluates the treatment outcome of the application of a technical medical device which is based on the principle of NPWT ( intervention group ) in comparison to standard moist wound therapy ( control group ) .", "sentence_id": 5}
+{"abstract_id": "25158846", "label": "methods", "text": "All treatment systems used in the intervention group bear the symbol of free trade capacity in the European Union ( CE mark ) and will be operated within normal conditions of clinical routine and according to manufacturer 's instructions .", "sentence_id": 6}
+{"abstract_id": "25158846", "label": "methods", "text": "Primary endpoints are the time to complete wound healing and the rate of wound healing achieved in each group within the maximum study treatment time of @weeks .", "sentence_id": 7}
+{"abstract_id": "25158846", "label": "methods", "text": "Primary endpoints will be confirmed by blinded assessment of wound photographs .", "sentence_id": 8}
+{"abstract_id": "25158846", "label": "conclusions", "text": "The DiaFu study will provide solid evidence regarding the efficacy and effectiveness of NPWT until @ December @ , the date when G-BA plans to decide on future reimbursement of NPWT in both ambulatory and in-hospital care .", "sentence_id": 9}
+{"abstract_id": "25158846", "label": "conclusions", "text": "The study is designed to comply with all quality requirements of G-BA and IQWiG and will contribute to evidence-based wound care in Germany .", "sentence_id": 10}
+{"abstract_id": "25158846", "label": "conclusions", "text": "The study has been initiated by the statutory health insurance companies in Germany and is co-funded by two manufacturers of NPWT systems .", "sentence_id": 11}
+{"abstract_id": "25038356", "label": "objective", "text": "Self-testing for HIV infection may contribute to early diagnosis of HIV , but without necessarily increasing antiretroviral therapy ( ART ) initiation .", "sentence_id": 0}
+{"abstract_id": "25038356", "label": "objective", "text": "To investigate whether offering optional home initiation of HIV care after HIV self-testing might increase demand for ART initiation , compared with HIV self-testing accompanied by facility-based services only .", "sentence_id": 1}
+{"abstract_id": "25038356", "label": "methods", "text": "Cluster randomized trial conducted in Blantyre , Malawi , between January @ and November @ , @ , using restricted @:@ randomization of @ community health worker catchment areas .", "sentence_id": 2}
+{"abstract_id": "25038356", "label": "methods", "text": "Participants were all adult ( @ years ) residents ( n = @,@ ) who received access to home HIV self-testing through resident volunteers .", "sentence_id": 3}
+{"abstract_id": "25038356", "label": "methods", "text": "This was a second-stage randomization of clusters allocated to the HIV self-testing group of a parent trial .", "sentence_id": 4}
+{"abstract_id": "25038356", "label": "methods", "text": "Clusters were randomly allocated to facility-based care or optional home initiation of HIV care ( including @ weeks of ART if eligible ) for participants reporting positive HIV self-test results .", "sentence_id": 5}
+{"abstract_id": "25038356", "label": "methods", "text": "The preplanned primary outcome compared between groups the proportion of all adult residents who initiated ART within the first @ months of HIV self-testing availability .", "sentence_id": 6}
+{"abstract_id": "25038356", "label": "methods", "text": "Secondary outcomes were uptake of HIV self-testing , reporting of positive HIV self-test results , and rates of loss from ART at @ months .", "sentence_id": 7}
+{"abstract_id": "25038356", "label": "results", "text": "A significantly greater proportion of adults in the home group initiated ART ( @/@ , @ % ) compared with the facility group ( @/@ , @ % ; risk ratio -LSB- RR -RSB- , @ , @ % CI , @-@ @ ; P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25038356", "label": "results", "text": "Uptake of HIV self-testing was high in both the home ( @/@ , @ % ) and facility groups ( @/@ , @ % ; RR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25038356", "label": "results", "text": "Significantly more adults reported positive HIV self-test results in the home group ( @/@ -LSB- @ % -RSB- vs the facility group , @/@ -LSB- @ % -RSB- ; RR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25038356", "label": "results", "text": "After @ months , @ of @ ART initiators ( @ % ) and @ of @ ART initiators ( @ % ) in the home and facility groups , respectively , were lost from ART ( adjusted incidence rate ratio , @ ; @ % CI , @-@ @ , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25038356", "label": "conclusions", "text": "Among Malawian adults offered HIV self-testing , optional home initiation of care compared with standard HIV care resulted in a significant increase in the proportion of adults initiating ART .", "sentence_id": 12}
+{"abstract_id": "25122422", "label": "background", "text": "Fluorescence in situ hybridization ( FISH ) is currently the standard for diagnosing anaplastic lymphoma kinase ( ALK ) - rearranged ( ALK + ) lung cancers for ALK inhibitor therapies .", "sentence_id": 0}
+{"abstract_id": "25122422", "label": "background", "text": "ALK immunohistochemistry ( IHC ) may serve as a screening and alternative diagnostic method .", "sentence_id": 1}
+{"abstract_id": "25122422", "label": "background", "text": "The Canadian ALK ( CALK ) study was initiated to implement a multicenter optimization and standardization of laboratory developed ALK IHC and FISH tests across @ hospitals .", "sentence_id": 2}
+{"abstract_id": "25122422", "label": "methods", "text": "Twenty-eight lung adenocarcinomas with known ALK status were used as blinded study samples .", "sentence_id": 3}
+{"abstract_id": "25122422", "label": "methods", "text": "Thirteen laboratories performed IHC using locally developed staining protocols for @A@ , ALK@ , or D@F@ antibodies ; results were assessed by H-score .", "sentence_id": 4}
+{"abstract_id": "25122422", "label": "methods", "text": "Twelve centers conducted FISH using protocols based on Vysis ' ALK break-apart FISH kit .", "sentence_id": 5}
+{"abstract_id": "25122422", "label": "methods", "text": "Initial IHC results were used to optimize local IHC protocols , followed by a repeat IHC study to assess the results of standardization .", "sentence_id": 6}
+{"abstract_id": "25122422", "label": "methods", "text": "Three laboratories conducted a prospective parallel IHC and FISH analysis on @ consecutive clinical samples using post-validation optimized assays .", "sentence_id": 7}
+{"abstract_id": "25122422", "label": "results", "text": "Among study samples , FISH demonstrated @ consensus ALK + and six ALK wild type tumors .", "sentence_id": 8}
+{"abstract_id": "25122422", "label": "results", "text": "Preoptimization IHC scores from @ centers with @A@ and the percent abnormal cells by FISH from @ centers showed intraclass correlation coefficients of @ and @ , respectively .", "sentence_id": 9}
+{"abstract_id": "25122422", "label": "results", "text": "IHC optimization improved the intraclass correlation coefficients to @ .", "sentence_id": 10}
+{"abstract_id": "25122422", "label": "results", "text": "Factors affecting FISH scoring and outliers were identified .", "sentence_id": 11}
+{"abstract_id": "25122422", "label": "results", "text": "Post-optimization concurrent IHC/FISH testing in @ informative cases revealed @ % sensitivity and specificity for IHC versus FISH .", "sentence_id": 12}
+{"abstract_id": "25122422", "label": "conclusions", "text": "Multicenter standardization study may accelerate the implementation of ALK testing protocols across a country/region .", "sentence_id": 13}
+{"abstract_id": "25122422", "label": "conclusions", "text": "Our data support the use of an appropriately validated IHC assay to screen for ALK + lung cancers .", "sentence_id": 14}
+{"abstract_id": "25033900", "label": "objective", "text": "To evaluate the changes in corneal sensation ( CS ) following two different port sizes vitrectomy in diabetic and non-diabetic patients .", "sentence_id": 0}
+{"abstract_id": "25033900", "label": "methods", "text": "Patients prepared for pars plana vitrectomy were randomly assigned to four groups : diabetics to either @G or @G and non-diabetics to either @G or @G vitrectomy systems .", "sentence_id": 1}
+{"abstract_id": "25033900", "label": "methods", "text": "CS was measured using the Cochet-Bonnet aesthesiometer at baseline preoperatively , and at @ day , @ week , and @ month postoperative .", "sentence_id": 2}
+{"abstract_id": "25033900", "label": "results", "text": "A total of @ eyes of @ patients were included in this study ; @ patients ( @ eyes ) in each of the @-G and @-G groups .", "sentence_id": 3}
+{"abstract_id": "25033900", "label": "results", "text": "The mean age was @ years and male/female ratio was @:@ .", "sentence_id": 4}
+{"abstract_id": "25033900", "label": "results", "text": "There were no significant difference between CS at baseline , and at @ day , @ week , and @ month between both the @-G and @-G groups .", "sentence_id": 5}
+{"abstract_id": "25033900", "label": "results", "text": "There were significant drops in CSs at @ day and @ week for both groups ( @G and @G ) with incomplete recovery for the @-G group and complete recovery for the @-G group .", "sentence_id": 6}
+{"abstract_id": "25033900", "label": "results", "text": "Comparing the two diabetic subgroups ( @G and @G ) and two non-diabetic subgroups ( @G and @G ) , there were no significant differences in CS between subgroups .", "sentence_id": 7}
+{"abstract_id": "25033900", "label": "results", "text": "Diabetics ' eyes had lower CSs throughout the study period in the @-G and @-G groups , which was significant at day@ and week @ postoperatively .", "sentence_id": 8}
+{"abstract_id": "25033900", "label": "conclusions", "text": "The vitrectomy procedure showed reduction in CS in the postoperative period with minimal nonsignificant difference between @G and @G systems .", "sentence_id": 9}
+{"abstract_id": "25033900", "label": "conclusions", "text": "However , diabetics ' eyes showed compromised CS preoperatively and a further significant reduction for @ month postoperatively compared with non-diabetics .", "sentence_id": 10}
+{"abstract_id": "24838215", "label": "objective", "text": "Steady-state visually evoked potential ( SSVEP ) - based brain-computer interfaces ( BCIs ) allow healthy subjects to communicate .", "sentence_id": 0}
+{"abstract_id": "24838215", "label": "objective", "text": "However , their dependence on gaze control prevents their use with severely disabled patients .", "sentence_id": 1}
+{"abstract_id": "24838215", "label": "objective", "text": "Gaze-independent SSVEP-BCIs have been designed but have shown a drop in accuracy and have not been tested in brain-injured patients .", "sentence_id": 2}
+{"abstract_id": "24838215", "label": "objective", "text": "In the present paper , we propose a novel independent SSVEP-BCI based on covert attention with an improved classification rate .", "sentence_id": 3}
+{"abstract_id": "24838215", "label": "objective", "text": "We study the influence of feature extraction algorithms and the number of harmonics .", "sentence_id": 4}
+{"abstract_id": "24838215", "label": "objective", "text": "Finally , we test online communication on healthy volunteers and patients with locked-in syndrome ( LIS ) .", "sentence_id": 5}
+{"abstract_id": "24838215", "label": "methods", "text": "Twenty-four healthy subjects and six LIS patients participated in this study .", "sentence_id": 6}
+{"abstract_id": "24838215", "label": "methods", "text": "An independent covert two-class SSVEP paradigm was used with a newly developed portable light emitting diode-based ` interlaced squares ' stimulation pattern .", "sentence_id": 7}
+{"abstract_id": "24838215", "label": "results", "text": "Mean offline and online accuracies on healthy subjects were respectively @ @ % and @ @ % , with eight out of twelve subjects succeeding to communicate efficiently with @ @ % accuracy .", "sentence_id": 8}
+{"abstract_id": "24838215", "label": "results", "text": "Two out of six LIS patients reached an offline accuracy above the chance level , illustrating a response to a command .", "sentence_id": 9}
+{"abstract_id": "24838215", "label": "results", "text": "One out of four LIS patients could communicate online .", "sentence_id": 10}
+{"abstract_id": "24838215", "label": "conclusions", "text": "We have demonstrated the feasibility of online communication with a covert SSVEP paradigm that is truly independent of all neuromuscular functions .", "sentence_id": 11}
+{"abstract_id": "24838215", "label": "conclusions", "text": "The potential clinical use of the presented BCI system as a diagnostic ( i.e. , detecting command-following ) and communication tool for severely brain-injured patients will need to be further explored .", "sentence_id": 12}
+{"abstract_id": "24615500", "label": "background", "text": "In the BOLERO-@ trial , everolimus ( EVE ) , an inhibitor of mammalian target of rapamycin , demonstrated significant clinical benefit with an acceptable safety profile when administered with exemestane ( EXE ) in postmenopausal women with hormone receptor-positive ( HR ( + ) ) advanced breast cancer .", "sentence_id": 0}
+{"abstract_id": "24615500", "label": "background", "text": "We report on the incidence , time course , severity , and resolution of treatment-emergent adverse events ( AEs ) as well as incidence of dose modifications during the extended follow-up of this study .", "sentence_id": 1}
+{"abstract_id": "24615500", "label": "methods", "text": "Patients were randomized ( @:@ ) to receive EVE @ mg/day or placebo ( PBO ) , with open-label EXE @ mg/day ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24615500", "label": "methods", "text": "The primary end point was progression-free survival .", "sentence_id": 3}
+{"abstract_id": "24615500", "label": "methods", "text": "Secondary end points included overall survival , objective response rate , and safety .", "sentence_id": 4}
+{"abstract_id": "24615500", "label": "methods", "text": "Safety evaluations included recording of AEs , laboratory values , dose interruptions/adjustments , and study drug discontinuations .", "sentence_id": 5}
+{"abstract_id": "24615500", "label": "results", "text": "The safety population comprised @ patients ( EVE + EXE , @ ; PBO + EXE , @ ) .", "sentence_id": 6}
+{"abstract_id": "24615500", "label": "results", "text": "The median follow-up was @ months .", "sentence_id": 7}
+{"abstract_id": "24615500", "label": "results", "text": "Class-effect toxicities , including stomatitis , pneumonitis , and hyperglycemia , were generally of mild or moderate severity and occurred relatively early after treatment initiation ( except pneumonitis ) ; incidence tapered off thereafter .", "sentence_id": 8}
+{"abstract_id": "24615500", "label": "results", "text": "EVE dose reduction and interruption ( @ and @ events , respectively ) required for AE management were independent of patient age .", "sentence_id": 9}
+{"abstract_id": "24615500", "label": "results", "text": "The median duration of dose interruption was @ days .", "sentence_id": 10}
+{"abstract_id": "24615500", "label": "results", "text": "Discontinuation of both study drugs because of AEs was higher with EVE + EXE ( @ % ) versus PBO + EXE ( @ % ) .", "sentence_id": 11}
+{"abstract_id": "24615500", "label": "conclusions", "text": "Most EVE-associated AEs occur soon after initiation of therapy , are typically of mild or moderate severity , and are generally manageable with dose reduction and interruption .", "sentence_id": 12}
+{"abstract_id": "24615500", "label": "conclusions", "text": "Discontinuation due to toxicity was uncommon .", "sentence_id": 13}
+{"abstract_id": "24615500", "label": "conclusions", "text": "Understanding the time course of class-effect AEs will help inform preventive and monitoring strategies as well as patient education .", "sentence_id": 14}
+{"abstract_id": "25526678", "label": "objective", "text": "The retrospective comparison of test and reference treatment arms in a randomized prospective clinical trial is potentially useful in economic modeling seeking to assess the cost effectiveness of alternative therapies .", "sentence_id": 0}
+{"abstract_id": "25526678", "label": "methods", "text": "To enhance the credibility of such retrospective comparisons , we propose the application of the following adjustments to significance levels obtained from standard statistical methodology : ( @ ) a significance test for the lower bound of the @ % confidence interval for the observed difference , ( @ ) a conservative Bonferroni method of adjustment for multiple comparisons , ( @ ) an adjusted p-value calculated using Scheffe 's single-step method , and ( @ ) Bayesian @ % credibility intervals with a prior centered at zero .", "sentence_id": 1}
+{"abstract_id": "25526678", "label": "results", "text": "These adjustments were applied to data from a randomized double-blind concurrent trial ( SPD@-@ ) that established the efficacy and safety of lisdexamfetamine dimesylate ( LDX ) in children and adolescents with attention-deficit/hyperactivity disorder ( ADHD ) .", "sentence_id": 2}
+{"abstract_id": "25526678", "label": "results", "text": "Prospectively planned analyses demonstrated that the reduction in the symptoms of ADHD was significantly greater than placebo in patients treated with either LDX or the reference treatment , osmotic-release oral system methylphenidate ( OROS-MPH ) .", "sentence_id": 3}
+{"abstract_id": "25526678", "label": "results", "text": "Retrospective analyses showed that the improvement in the symptoms of ADHD was greater in patients treated with LDX than OROS-MPH .", "sentence_id": 4}
+{"abstract_id": "25526678", "label": "results", "text": "We now show that this observation remained significant after the application of the four statistical penalties .", "sentence_id": 5}
+{"abstract_id": "25526678", "label": "conclusions", "text": "By adjusting the significance level , it is possible to compare quantitatively such retrospective results with prospectively defined comparisons .", "sentence_id": 6}
+{"abstract_id": "25526678", "label": "conclusions", "text": "However , the qualitative level of such retrospective evidence should remain secondary to that obtained from prospectively specified comparisons in a randomized clinical trial .", "sentence_id": 7}
+{"abstract_id": "25304446", "label": "background", "text": "Alzheimer 's disease is characterised by a loss of cognitive function and behavioural problems as set out in the term `` Behavioural and Psychological Symptoms of Dementia '' .", "sentence_id": 0}
+{"abstract_id": "25304446", "label": "background", "text": "These behavioural symptoms have heavy consequences for the patients and their families .", "sentence_id": 1}
+{"abstract_id": "25304446", "label": "background", "text": "A greater understanding of behavioural symptoms risk factors would allow better detection of those patients , a better understanding of crisis situations and better management of these patients .", "sentence_id": 2}
+{"abstract_id": "25304446", "label": "background", "text": "Some retrospective studies or simple observations suggested that personality could play a role in the occurrence of behavioural symptoms .", "sentence_id": 3}
+{"abstract_id": "25304446", "label": "background", "text": "Finally , performance in social cognition like facial recognition and perspective taking could be linked to certain personality traits and the subsequent risks of behavioural symptoms .", "sentence_id": 4}
+{"abstract_id": "25304446", "label": "background", "text": "We propose to clarify this through a prospective , multicentre , multidisciplinary study .", "sentence_id": 5}
+{"abstract_id": "25304446", "label": "background", "text": "Main Objective : - To assess the effect of personality and life events on the risk of developing behavioural symptoms .", "sentence_id": 6}
+{"abstract_id": "25304446", "label": "background", "text": "Secondary Objectives : - To evaluate , at the time of inclusion , the connection between personality and performance in social cognition tests ; - To evaluate the correlation between performance in social cognition at inclusion and the risks of occurrence of behavioural symptoms ; - To evaluate the correlation between regional cerebral atrophy , using brain Magnetic Resonance Imaging at baseline , and the risk of behavioural symptoms .", "sentence_id": 7}
+{"abstract_id": "25304446", "label": "methods", "text": "Study type and Population : Prospective multicentre cohort study with @ patients with Alzheimer 's disease at prodromal or mild dementia stage .", "sentence_id": 8}
+{"abstract_id": "25304446", "label": "methods", "text": "The inclusion period will be of @ months and the patients will be followed during @ months .", "sentence_id": 9}
+{"abstract_id": "25304446", "label": "methods", "text": "The initial evaluation will include : a clinical and neuropsychological examination , collection of behavioural symptoms data ( Neuropsychiatric-Inventory scale ) and their risk factors , a personality study using both a dimensional ( personality traits ) and categorical approach , an inventory of life events , social cognition tests and an Magnetic Resonance Imaging .", "sentence_id": 10}
+{"abstract_id": "25304446", "label": "methods", "text": "Patients will be followed every @ months ( clinical examination and collection of behavioural symptoms data and risk factors ) during @ months .", "sentence_id": 11}
+{"abstract_id": "25304446", "label": "conclusions", "text": "This study aims at better identifying the patients with Alzheimer 's disease at high risk of developing behavioural symptoms , to anticipate , detect and quickly treat these disorders and so , prevent serious consequences for the patient and his caregivers .", "sentence_id": 12}
+{"abstract_id": "26062183", "label": "objective", "text": "To explore the effective therapeutic method for reducing adductor muscle tension in the children of spasmodic cerebral palsy .", "sentence_id": 0}
+{"abstract_id": "26062183", "label": "methods", "text": "One hundred and forty cases of spasmodic cerebral palsy met the inclusive criteria were randomized into an observation group and a control group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "26062183", "label": "methods", "text": "In the control group , the conventional physical therapies ( Bobath therapy and lower extremities therapy ) and scalp acupuncture ( seven-intelligent needles , motor area , sensory area , foot-motor-sensory area and balance area ) were adopted .", "sentence_id": 2}
+{"abstract_id": "26062183", "label": "methods", "text": "In the observation group , on the basis of the treatment as the control group , the three-spasm-needle therapy was applied to Jiejian , Xuehaishang and Houxuehai .", "sentence_id": 3}
+{"abstract_id": "26062183", "label": "methods", "text": "The physical therapies were given once every day , acupuncture was given once every two days , the treatment of @ days made one session .", "sentence_id": 4}
+{"abstract_id": "26062183", "label": "methods", "text": "There were @ to @ days at the interval among the sessions and @ sessions were required totally .", "sentence_id": 5}
+{"abstract_id": "26062183", "label": "methods", "text": "Separately before and after treatment , the modified Ashworth scale was used to evaluate the adductor muscle tension , and measure the adductor muscle angle , and D and E regions of gross motor function measure ( GMFM-@ ) were adopted for clinical efficacy evaluation .", "sentence_id": 6}
+{"abstract_id": "26062183", "label": "results", "text": "After treatment , the scores of the adductor muscle tension were decreased to different extends in the two groups ( both P < @ ) , the adductor muscle angle was increased as compared with that before treatment ( both P < @ ) and the scores of D and F regions in GMFM-@ were all improved ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "26062183", "label": "results", "text": "The efficacy in the observation group was more significant than that in the control group ( all P < @ ) .", "sentence_id": 8}
+{"abstract_id": "26062183", "label": "conclusions", "text": "The three-spasm-needle therapy effectively reduces adductor muscle tension and improves the range of motion in hip joint , independent walking , running and jumping abilities in the children of spasmodic cerebral palsy .", "sentence_id": 9}
+{"abstract_id": "25176289", "label": "background", "text": "We hypothesized that in patients with stable coronary artery disease and stenosis , percutaneous coronary intervention ( PCI ) performed on the basis of the fractional flow reserve ( FFR ) would be superior to medical therapy .", "sentence_id": 0}
+{"abstract_id": "25176289", "label": "methods", "text": "In @ patients with stable coronary artery disease , we assessed the FFR in all stenoses that were visible on angiography .", "sentence_id": 1}
+{"abstract_id": "25176289", "label": "methods", "text": "Patients who had at least one stenosis with an FFR of @ or less were randomly assigned to undergo FFR-guided PCI plus medical therapy or to receive medical therapy alone .", "sentence_id": 2}
+{"abstract_id": "25176289", "label": "methods", "text": "Patients in whom all stenoses had an FFR of more than @ received medical therapy alone and were included in a registry .", "sentence_id": 3}
+{"abstract_id": "25176289", "label": "methods", "text": "The primary end point was a composite of death from any cause , nonfatal myocardial infarction , or urgent revascularization within @ years .", "sentence_id": 4}
+{"abstract_id": "25176289", "label": "results", "text": "The rate of the primary end point was significantly lower in the PCI group than in the medical-therapy group ( @ % vs. @ % ; hazard ratio , @ ; @ % confidence interval -LSB- CI -RSB- , @ to @ ; P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25176289", "label": "results", "text": "This reduction was driven by a lower rate of urgent revascularization in the PCI group ( @ % vs. @ % ; hazard ratio , @ ; @ % CI , @ to @ ; P < @ ) , with no significant between-group differences in the rates of death and myocardial infarction .", "sentence_id": 6}
+{"abstract_id": "25176289", "label": "results", "text": "Urgent revascularizations that were triggered by myocardial infarction or ischemic changes on electrocardiography were less frequent in the PCI group ( @ % vs. @ % , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25176289", "label": "results", "text": "In a landmark analysis , the rate of death or myocardial infarction from @ days to @ years was lower in the PCI group than in the medical-therapy group ( @ % vs. @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25176289", "label": "results", "text": "Among registry patients , the rate of the primary end point was @ % at @ years .", "sentence_id": 9}
+{"abstract_id": "25176289", "label": "conclusions", "text": "In patients with stable coronary artery disease , FFR-guided PCI , as compared with medical therapy alone , improved the outcome .", "sentence_id": 10}
+{"abstract_id": "25176289", "label": "conclusions", "text": "Patients without ischemia had a favorable outcome with medical therapy alone .", "sentence_id": 11}
+{"abstract_id": "25176289", "label": "conclusions", "text": "( Funded by St. Jude Medical ; FAME @ ClinicalTrials.gov number , NCT@ . )", "sentence_id": 12}
+{"abstract_id": "24721289", "label": "background", "text": "Advertising has been implicated in the declining quality of the American diet , but much of the research has been conducted with children rather than adults .", "sentence_id": 0}
+{"abstract_id": "24721289", "label": "background", "text": "This study tested the effects of televised food advertising on adult food choice .", "sentence_id": 1}
+{"abstract_id": "24721289", "label": "methods", "text": "Participants ( N = @ ) were randomized into one of @ experimental conditions : exposure to food advertising vs. exposure to non-food advertising , and within each of these groups , exposure to a task that was either cognitively demanding or not cognitively demanding .", "sentence_id": 2}
+{"abstract_id": "24721289", "label": "methods", "text": "The number of unhealthy snacks chosen was subsequently measured , along with total calories of the snacks chosen .", "sentence_id": 3}
+{"abstract_id": "24721289", "label": "results", "text": "Those exposed to food advertising chose @ % more unhealthy snacks than those exposed to non-food-advertising ( @ % CI : @ % - @ % ) , with a total caloric value that was @ kcal higher ( @ % CI : @-@ ) .", "sentence_id": 4}
+{"abstract_id": "24721289", "label": "results", "text": "The effect of advertising was not significant among those assigned to the low-cognitive-load group , but was large and significant among those assigned to the high-cognitive-load group : @ % more unhealthy snacks ( @ % CI : @ % - @ % ) and @ more total calories ( @ % CI : @-@ ) .", "sentence_id": 5}
+{"abstract_id": "24721289", "label": "conclusions", "text": "Televised food advertising has strong effects on individual food choice , and these effects are magnified when individuals are cognitively occupied by other tasks .", "sentence_id": 6}
+{"abstract_id": "25440820", "label": "objective", "text": "To evaluate of efficacy of transgluteal ( supine ) approach for shock wave lithotripsy ( SWL ) in treatment of distal ureteric stones .", "sentence_id": 0}
+{"abstract_id": "25440820", "label": "methods", "text": "This prospective , randomized , comparative study was conducted on @ patients .", "sentence_id": 1}
+{"abstract_id": "25440820", "label": "methods", "text": "Patients were randomly assigned into @ groups : group A ( n = @ ; prone position ) and group B ( n = @ ; supine position , transgluteal ) .", "sentence_id": 2}
+{"abstract_id": "25440820", "label": "methods", "text": "Inclusion criteria included patients with radiopaque lower ureteric stones @ mm .", "sentence_id": 3}
+{"abstract_id": "25440820", "label": "methods", "text": "Exclusion criteria included radiolucent stones , stones > @ mm , the need for any auxiliary procedure , and any contraindication for SWL .", "sentence_id": 4}
+{"abstract_id": "25440820", "label": "methods", "text": "Post-SWL evaluation included plain x-ray of kidney , ureter , and bladder at @ weeks after treatment and then at monthly intervals after treatment for @ months .", "sentence_id": 5}
+{"abstract_id": "25440820", "label": "methods", "text": "Stone-free status was defined as no residual stone fragments visible on plain x-ray .", "sentence_id": 6}
+{"abstract_id": "25440820", "label": "methods", "text": "Treatment failure was defined as persistence of stone fragments at @ months or the need for ureteroscopy .", "sentence_id": 7}
+{"abstract_id": "25440820", "label": "results", "text": "Stone-free rate after @ treatment session was achieved in @ % and @ % for prone and supine positions , respectively .", "sentence_id": 8}
+{"abstract_id": "25440820", "label": "results", "text": "Proceeding to ureteroscopy , after failure of the second SWL session to clear the stones , was done in @ % and @ % for prone and supine positions , respectively .", "sentence_id": 9}
+{"abstract_id": "25440820", "label": "results", "text": "The overall success rate for SWL treatment in prone and supine groups was @ % and @ % , respectively ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25440820", "label": "conclusions", "text": "Transgluteal SWL while patient in supine position proved efficacy for treatment of distal ureteric stones .", "sentence_id": 11}
+{"abstract_id": "25440820", "label": "conclusions", "text": "Larger group studies comparing the results of SWL in supine position with those of prone position and also with those of ureteroscopy may enrich our data to reach a consensus for the ideal management of distal ureteric stones .", "sentence_id": 12}
+{"abstract_id": "24682026", "label": "objective", "text": "Transcatheter aortic valve replacement ( TAVR ) is an effective treatment option for high-risk patients with severe aortic stenosis .", "sentence_id": 0}
+{"abstract_id": "24682026", "label": "objective", "text": "Different from surgery , transcatheter deployment of valves requires either a balloon-expandable or self-expandable system .", "sentence_id": 1}
+{"abstract_id": "24682026", "label": "objective", "text": "A randomized comparison of these @ systems has not been performed .", "sentence_id": 2}
+{"abstract_id": "24682026", "label": "objective", "text": "To determine whether the balloon-expandable device is associated with a better success rate than the self-expandable device .", "sentence_id": 3}
+{"abstract_id": "24682026", "label": "methods", "text": "The CHOICE study was an investigator-initiated trial in high-risk patients with severe aortic stenosis and an anatomy suitable for the transfemoral TAVR procedure .", "sentence_id": 4}
+{"abstract_id": "24682026", "label": "methods", "text": "One hundred twenty-one patients were randomly assigned to receive a balloon-expandable valve ( Edwards Sapien XT ) and @ were assigned to receive a self-expandable valve ( Medtronic CoreValve ) .", "sentence_id": 5}
+{"abstract_id": "24682026", "label": "methods", "text": "Patients were enrolled between March @ and December @ at @ centers in Germany .", "sentence_id": 6}
+{"abstract_id": "24682026", "label": "methods", "text": "Transfemoral TAVR with a balloon-expandable or self-expandable device .", "sentence_id": 7}
+{"abstract_id": "24682026", "label": "methods", "text": "The primary end point was device success , which is a composite end point including successful vascular access and deployment of the device and retrieval of the delivery system , correct position of the device , intended performance of the heart valve without moderate or severe regurgitation , and only @ valve implanted in the proper anatomical location .", "sentence_id": 8}
+{"abstract_id": "24682026", "label": "methods", "text": "Secondary end points included cardiovascular mortality , bleeding and vascular complications , postprocedural pacemaker placement , and a combined safety end point at @ days , including all-cause mortality , major stroke , and other serious complications .", "sentence_id": 9}
+{"abstract_id": "24682026", "label": "results", "text": "Device success occurred in @ of @ patients ( @ % ) in the balloon-expandable valve group and @ of @ patients ( @ % ) in the self-expandable valve group ( relative risk -LSB- RR -RSB- , @ , @ % CI , @-@ @ , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24682026", "label": "results", "text": "This was attributed to a significantly lower frequency of residual more-than-mild aortic regurgitation ( @ % vs @ % ; RR , @ ; @ % CI , @-@ @ ; P < @ ) and the less frequent need for implanting more than @ valve ( @ % vs @ % , P = @ ) in the balloon-expandable valve group .", "sentence_id": 11}
+{"abstract_id": "24682026", "label": "results", "text": "Cardiovascular mortality at @ days was @ % in the balloon-expandable valve group and @ % in the self-expandable valve group ( RR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24682026", "label": "results", "text": "Bleeding and vascular complications were not significantly different , and the combined safety end point occurred in @ % of those in the balloon-expandable valve group and @ % of the self-expandable valve group ( RR , @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 13}
+{"abstract_id": "24682026", "label": "results", "text": "Placement of a new permanent pacemaker was less frequent in the balloon-expandable valve group ( @ % vs @ % , P = @ ) .", "sentence_id": 14}
+{"abstract_id": "24682026", "label": "conclusions", "text": "Among patients with high-risk aortic stenosis undergoing TAVR , the use of a balloon-expandable valve resulted in a greater rate of device success than use of a self-expandable valve .", "sentence_id": 15}
+{"abstract_id": "25058216", "label": "objective", "text": "There is limited information about the effect of erythropoietin or a high hemoglobin transfusion threshold after a traumatic brain injury .", "sentence_id": 0}
+{"abstract_id": "25058216", "label": "objective", "text": "To compare the effects of erythropoietin and @ hemoglobin transfusion thresholds ( @ and @ g/dL ) on neurological recovery after traumatic brain injury .", "sentence_id": 1}
+{"abstract_id": "25058216", "label": "methods", "text": "Randomized clinical trial of @ patients ( erythropoietin , n = @ ; placebo , n = @ ) with closed head injury who were unable to follow commands and were enrolled within @ hours of injury at neurosurgical intensive care units in @ US level I trauma centers between May @ and August @ .", "sentence_id": 2}
+{"abstract_id": "25058216", "label": "methods", "text": "The study used a factorial design to test whether erythropoietin would fail to improve favorable outcomes by @ % and whether a hemoglobin transfusion threshold of greater than @ g/dL would increase favorable outcomes without increasing complications .", "sentence_id": 3}
+{"abstract_id": "25058216", "label": "methods", "text": "Erythropoietin or placebo was initially dosed daily for @ days and then weekly for @ more weeks ( n = @ ) and then the @ - and @-hour doses were stopped for the remainder of the patients ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25058216", "label": "methods", "text": "There were @ patients assigned to a hemoglobin transfusion threshold of @ g/dL and @ patients assigned to @ g/dL .", "sentence_id": 5}
+{"abstract_id": "25058216", "label": "methods", "text": "Intravenous erythropoietin ( @ IU/kg per dose ) or saline .", "sentence_id": 6}
+{"abstract_id": "25058216", "label": "methods", "text": "Transfusion threshold maintained with packed red blood cells .", "sentence_id": 7}
+{"abstract_id": "25058216", "label": "methods", "text": "Glasgow Outcome Scale score dichotomized as favorable ( good recovery and moderate disability ) or unfavorable ( severe disability , vegetative , or dead ) at @ months postinjury .", "sentence_id": 8}
+{"abstract_id": "25058216", "label": "results", "text": "There was no interaction between erythropoietin and hemoglobin transfusion threshold .", "sentence_id": 9}
+{"abstract_id": "25058216", "label": "results", "text": "Compared with placebo ( favorable outcome rate : @/@ -LSB- @ % ; @ % CI , @ % to @ % -RSB- ) , both erythropoietin groups were futile ( first dosing regimen : @/@ -LSB- @ % ; @ % CI , @ % to @ % -RSB- , P = @ ; second dosing regimen : @/@ -LSB- @ % ; @ % CI , @ % to @ % -RSB- , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25058216", "label": "results", "text": "Favorable outcome rates were @/@ ( @ % ) for the hemoglobin transfusion threshold of @ g/dL and @/@ ( @ % ) for @ g/dL ( @ % CI for the difference , -@ to @ , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25058216", "label": "results", "text": "There was a higher incidence of thromboembolic events for the transfusion threshold of @ g/dL ( @/@ -LSB- @ % -RSB- vs @/@ -LSB- @ % -RSB- for the threshold of @ g/dL , odds ratio , @ -LSB- @ % CI , @ to @ -RSB- , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25058216", "label": "conclusions", "text": "In patients with closed head injury , neither the administration of erythropoietin nor maintaining hemoglobin concentration of greater than @ g/dL resulted in improved neurological outcome at @ months .", "sentence_id": 13}
+{"abstract_id": "25058216", "label": "conclusions", "text": "The transfusion threshold of @ g/dL was associated with a higher incidence of adverse events .", "sentence_id": 14}
+{"abstract_id": "25058216", "label": "conclusions", "text": "These findings do not support either approach in this setting .", "sentence_id": 15}
+{"abstract_id": "25819861", "label": "background", "text": "Poor adherence to evidence-based medications in heart failure ( HF ) is a major cause of avoidable hospitalizations , disability , and death .", "sentence_id": 0}
+{"abstract_id": "25819861", "label": "background", "text": "To test the feasibility of improving medication adherence , we performed a randomized proof-of-concept study of a self-management intervention in high-risk patients with HF .", "sentence_id": 1}
+{"abstract_id": "25819861", "label": "methods", "text": "Patients with HF who screened positively for poor adherence ( < @ Morisky Medication Adherence Scale @-item ) were randomized to either the intervention or attention control group .", "sentence_id": 2}
+{"abstract_id": "25819861", "label": "methods", "text": "In the intervention group ( n = @ ) , a nurse conducted self-management training before discharge that focused on identification of medication goals , facilitation of medication-symptom associations , and use of a symptom response plan .", "sentence_id": 3}
+{"abstract_id": "25819861", "label": "methods", "text": "The attention control group ( n = @ ) received usual care ; both groups received follow-up calls at @ week .", "sentence_id": 4}
+{"abstract_id": "25819861", "label": "methods", "text": "However , the content of follow-up calls for the attention control group was unrelated to HF medications or symptoms .", "sentence_id": 5}
+{"abstract_id": "25819861", "label": "methods", "text": "General linear mixed models were used to evaluate the magnitude of change in adherence and symptom-related events at @ - , @ - , and @-month follow-up clinic visits .", "sentence_id": 6}
+{"abstract_id": "25819861", "label": "methods", "text": "Efficacy was measured as improved medication adherence using nurse-assessed pill counts at each time point .", "sentence_id": 7}
+{"abstract_id": "25819861", "label": "results", "text": "Pooled over all time points , patients in the intervention group were more likely to be adherent to medications compared with patients in the attention control group ( odds ratio @ , t = @ , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25819861", "label": "conclusions", "text": "A nurse-delivered , self-care intervention improved medication adherence in patients with advanced HF .", "sentence_id": 9}
+{"abstract_id": "25819861", "label": "conclusions", "text": "Further work is needed to examine whether this intervention can be sustained to improve clinical outcomes .", "sentence_id": 10}
+{"abstract_id": "25499341", "label": "background", "text": "The Rho-kinase pathway has been shown to be involved in the pathogenesis of PAH .", "sentence_id": 0}
+{"abstract_id": "25499341", "label": "background", "text": "As yet , however , the acute effects of the Rho-kinase inhibitor fasudil have not been compared with established pulmonary selective vasodilators in patients with PAH .", "sentence_id": 1}
+{"abstract_id": "25499341", "label": "background", "text": "We compared the acute effects of intravenous fasudil with inhaled iloprost in patients with pulmonary arterial hypertension ( PAH ) .", "sentence_id": 2}
+{"abstract_id": "25499341", "label": "methods", "text": "Using a crossover design , @ patients with PAH ( idiopathic PAH , PAH associated with repaired left-to-right cardiac shunts , or connective tissue disease ) were randomized to iloprost inhalation ( @ g ) and intravenous fasudil ( @ mg over @ min ) .", "sentence_id": 3}
+{"abstract_id": "25499341", "label": "methods", "text": "Hemodynamic data were collected at baseline and during acute drug exposure .", "sentence_id": 4}
+{"abstract_id": "25499341", "label": "results", "text": "Comparable decreases were observed in mean pulmonary artery pressure ( -@ @ mmHg vs. -@ @ mmHg ) and pulmonary vascular resistance ( -@ @ Wood U vs. -@ @ Wood U ) with fasudil infusion and iloprost inhalation , respectively , during acute challenge .", "sentence_id": 5}
+{"abstract_id": "25499341", "label": "results", "text": "However , fasudil infusion resulted in a more pronounced increase in mean cardiac output and mixed venous oxygen saturation compared with iloprost inhalation ( @ @ % vs. @ @ % ; p = @ and @ @ % vs. @ @ % ; p = @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "25499341", "label": "results", "text": "Whereas inhaled iloprost resulted in a non-significant increase in mean systemic arterial oxygen saturation ( @ @ % ) , infused fasudil resulted in a non-significant reduction ( -@ @ % ) .", "sentence_id": 7}
+{"abstract_id": "25499341", "label": "conclusions", "text": "Infused fasudil improved pulmonary hemodynamics in patients with PAH without significant toxicity .", "sentence_id": 8}
+{"abstract_id": "25457929", "label": "objective", "text": "Prior research has shown that youth with co-occurring tic disorders and obsessive-compulsive disorder ( OCD ) may differ from those with non-tic-related OCD in terms of clinical characteristics and treatment responsiveness .", "sentence_id": 0}
+{"abstract_id": "25457929", "label": "objective", "text": "A broad definition of `` tic-related '' was used to examine whether children with tics in the Pediatric OCD Treatment Study II differed from those without tics in terms of demographic and phenomenological characteristics and acute treatment outcomes .", "sentence_id": 1}
+{"abstract_id": "25457929", "label": "methods", "text": "Participants were @ youth aged @ to @ years , inclusive , with a primary diagnosis of OCD who were partial responders to an adequate serotonin reuptake inhibitor ( SRI ) trial .", "sentence_id": 2}
+{"abstract_id": "25457929", "label": "methods", "text": "Participants were randomized to medication management , medication management plus instructions in cognitive-behavioral therapy ( CBT ) , or medication management plus full CBT .", "sentence_id": 3}
+{"abstract_id": "25457929", "label": "methods", "text": "Tic status was based on the presence of motor and/or vocal tics on the Yale Global Tic Severity Scale .", "sentence_id": 4}
+{"abstract_id": "25457929", "label": "results", "text": "Tics were identified in @ % of the sample .", "sentence_id": 5}
+{"abstract_id": "25457929", "label": "results", "text": "Those with tic-related OCD did not differ from those with non-tic-related OCD in terms of age , family history of tics , OCD severity , OCD-related impairment , or comorbidity .", "sentence_id": 6}
+{"abstract_id": "25457929", "label": "results", "text": "Those with tics responded equally in all treatment conditions .", "sentence_id": 7}
+{"abstract_id": "25457929", "label": "conclusions", "text": "Tic-related OCD was very prevalent using a broad definition of tic status .", "sentence_id": 8}
+{"abstract_id": "25457929", "label": "conclusions", "text": "Results suggest that youth with this broad definition of tic-related OCD do not have increased OCD severity or inference , higher comorbidity rates or severity , or worsened functioning , and support the use of CBT in this population .", "sentence_id": 9}
+{"abstract_id": "25457929", "label": "conclusions", "text": "This highlights the importance of not making broad assumptions about OCD symptoms most likely to occur in an individual with comorbid tics .", "sentence_id": 10}
+{"abstract_id": "25457929", "label": "conclusions", "text": "Clinical trial registration information-Treatment of Pediatric OCD for SRI Partial Responders ; http://clinicaltrials.gov; NCT@ .", "sentence_id": 11}
+{"abstract_id": "24443001", "label": "objective", "text": "Since clinical non-response to @mg rituximab has previously been found to be associated with incomplete B cell depletion , we determined , in a randomised controlled proof of concept study , whether patients with initial incomplete B cell depletion would benefit from an additional infusion of rituximab at week @ .", "sentence_id": 0}
+{"abstract_id": "24443001", "label": "methods", "text": "Patients with active rheumatoid arthritis despite methotrexate received a first infusion of rituximab @mg and were tested for persistent B cells using highly sensitive flow cytometry on day @ .", "sentence_id": 1}
+{"abstract_id": "24443001", "label": "methods", "text": "All received a second infusion of @g ( according to license ) , but patients with persistent B cells were subsequently randomised double-blind to receive , @weeks later , either a third infusion of @mg rituximab or placebo .", "sentence_id": 2}
+{"abstract_id": "24443001", "label": "methods", "text": "Clinical response was determined by European League Against Rheumatism ( EULAR ) and American College of Rheumatology ( ACR ) criteria .", "sentence_id": 3}
+{"abstract_id": "24443001", "label": "results", "text": "Baseline characteristics were balanced between groups .", "sentence_id": 4}
+{"abstract_id": "24443001", "label": "results", "text": "Treatment with @mg rituximab resulted in significantly greater depletion ( lower B cell and plasmablast numbers between @ and @weeks ) paralleled by significantly better EULAR and ACR@ response rates at @weeks ( p = @ and p = @ , respectively ) and @weeks ( p = @ and p = @ , respectively ) compared with @mg .", "sentence_id": 5}
+{"abstract_id": "24443001", "label": "results", "text": "Immunoglobulin titres remained stable in both arms , and adverse event rates were balanced .", "sentence_id": 6}
+{"abstract_id": "24443001", "label": "conclusions", "text": "In rituximab-treated patients with incomplete B cell depletion ( predictive of poor response ) , an extra @mg infusion of rituximab at @weeks produced both better depletion and clinical responses than placebo with no worsening of safety .", "sentence_id": 7}
+{"abstract_id": "24443001", "label": "conclusions", "text": "Degree of depletion is an important , but modifiable , determinant of response .", "sentence_id": 8}
+{"abstract_id": "25337948", "label": "objective", "text": "To compare treatment effects when patients with insomnia and depression receive treatment for either insomnia or depression .", "sentence_id": 0}
+{"abstract_id": "25337948", "label": "methods", "text": "A @-w randomized controlled trial with @ - and @-mo follow-up .", "sentence_id": 1}
+{"abstract_id": "25337948", "label": "methods", "text": "Internet Psychiatry Clinic , Stockholm , Sweden .", "sentence_id": 2}
+{"abstract_id": "25337948", "label": "methods", "text": "Forty-three adults in whom comorbid insomnia and depression were diagnosed , recruited via media and assessed by psychiatrists .", "sentence_id": 3}
+{"abstract_id": "25337948", "label": "methods", "text": "Guided Internet-delivered cognitive behavior therapy ( ICBT ) for either insomnia or depression .", "sentence_id": 4}
+{"abstract_id": "25337948", "label": "results", "text": "Primary outcome measures were symptom self-rating scales ( Insomnia Severity Index -LSB- ISI -RSB- and the Montgomery sberg Depression Rating Scale -LSB- MADRS-S -RSB- ) , assessed before and after treatment with follow-up after @ and @ mo. .", "sentence_id": 5}
+{"abstract_id": "25337948", "label": "results", "text": "The participants ' use of sleep medication and need for further treatment after completion of ICBT was also investigated .", "sentence_id": 6}
+{"abstract_id": "25337948", "label": "results", "text": "The insomnia treatment was more effective than the depression treatment in reducing insomnia severity during treatment ( P = @ ) , and equally effective in reducing depression severity .", "sentence_id": 7}
+{"abstract_id": "25337948", "label": "results", "text": "Group differences in insomnia severity were maintained during the @-mo follow-up period .", "sentence_id": 8}
+{"abstract_id": "25337948", "label": "results", "text": "Post treatment , participants receiving treatment for insomnia had significantly less self-rated need for further insomnia treatment ( P < @ ) and used less sleep medication ( P < @ ) than participants receiving treatment for depression .", "sentence_id": 9}
+{"abstract_id": "25337948", "label": "results", "text": "The need for depression treatment was similar in both groups .", "sentence_id": 10}
+{"abstract_id": "25337948", "label": "conclusions", "text": "In this study , Internet-delivered treatment with cognitive behavior therapy ( ICBT ) for insomnia was more effective than ICBT for depression for patients with both diagnoses .", "sentence_id": 11}
+{"abstract_id": "25337948", "label": "conclusions", "text": "This indicates , in line with previous research , that insomnia when comorbid with depression is not merely a symptom of depression , but needs specific treatment .", "sentence_id": 12}
+{"abstract_id": "25044799", "label": "objective", "text": "To identify an early treatment milestone that optimizes sensitivity and specificity for predicting @ % weight loss at Week ( W ) @ in patients with and without type @ diabetes on lorcaserin or placebo .", "sentence_id": 0}
+{"abstract_id": "25044799", "label": "methods", "text": "Post hoc area under the curve for receiver operating characteristic analyses of data from three phase @ trials comparing lifestyle modification + placebo with lifestyle modification + lorcaserin .", "sentence_id": 1}
+{"abstract_id": "25044799", "label": "methods", "text": "A total of @ patients ( @-@ years ; BMI , @-@ or @-@ @ kg/m ( @ ) with @ comorbidity ) were randomized to placebo or lorcaserin @ mg bid .", "sentence_id": 2}
+{"abstract_id": "25044799", "label": "methods", "text": "Changes ( baseline to W@ ) in cardiometabolic parameters were assessed .", "sentence_id": 3}
+{"abstract_id": "25044799", "label": "results", "text": "Response ( @ % weight loss from baseline ) at W@ was a strong predictor of W@ response .", "sentence_id": 4}
+{"abstract_id": "25044799", "label": "results", "text": "Lorcaserin patients with a W@ response achieved mean W@ weight losses of @ kg ( without diabetes ) and @ kg ( with diabetes ) .", "sentence_id": 5}
+{"abstract_id": "25044799", "label": "results", "text": "Proportions achieving @ % and @ % weight loss at W@ were @ % and @ % ( without diabetes ) , and @ % and @ % ( with diabetes ) .", "sentence_id": 6}
+{"abstract_id": "25044799", "label": "results", "text": "Lorcaserin patients who did not achieve a W@ response lost @ kg ( without diabetes ) and @ kg ( with diabetes ) at W@ .", "sentence_id": 7}
+{"abstract_id": "25044799", "label": "results", "text": "Responders had greater improvements in cardiometabolic risk factors than the modified intent-to-treat ( MITT ) population , consistent with greater weight loss .", "sentence_id": 8}
+{"abstract_id": "25044799", "label": "conclusions", "text": "@ % weight loss by W@ predicts robust response to lorcaserin at @ year .", "sentence_id": 9}
+{"abstract_id": "25427135", "label": "objective", "text": "We evaluated a novel visual representation for current and near-term prosthetic vision .", "sentence_id": 0}
+{"abstract_id": "25427135", "label": "objective", "text": "Augmented depth emphasizes ground obstacles and floor-wall boundaries in a depth-based visual representation .", "sentence_id": 1}
+{"abstract_id": "25427135", "label": "objective", "text": "This is achieved by artificially increasing contrast between obstacles and the ground surface via a novel ground plane extraction algorithm specifically designed to preserve low-contrast ground-surface boundaries .", "sentence_id": 2}
+{"abstract_id": "25427135", "label": "methods", "text": "The effectiveness of augmented depth was examined in human mobility trials compared against standard intensity-based ( Intensity ) , depth-based ( Depth ) and random ( Random ) visual representations .", "sentence_id": 3}
+{"abstract_id": "25427135", "label": "methods", "text": "Eight participants with normal vision used simulated prosthetic vision with @ phosphenes and eight perceivable brightness levels to traverse a course with randomly placed small and low-contrast obstacles on the ground .", "sentence_id": 4}
+{"abstract_id": "25427135", "label": "results", "text": "The number of collisions was significantly reduced using augmented depth , compared with intensity , depth and random representations ( @ % , @ % and @ % less collisions , respectively ) .", "sentence_id": 5}
+{"abstract_id": "25427135", "label": "conclusions", "text": "These results indicate that augmented depth may enable safe mobility in the presence of low-contrast obstacles with current and near-term implants .", "sentence_id": 6}
+{"abstract_id": "25427135", "label": "conclusions", "text": "This is the first demonstration that an augmentation of the scene ensuring key objects are visible may provide better outcomes for prosthetic vision .", "sentence_id": 7}
+{"abstract_id": "24511717", "label": "background", "text": "From the empirical study , light-emitting diode ( LED ) phototherapy is effective for treatment of neonatal hyperbilirubinemia .", "sentence_id": 0}
+{"abstract_id": "24511717", "label": "background", "text": "However commercial LED phototherapy equipment is still expensive .", "sentence_id": 1}
+{"abstract_id": "24511717", "label": "background", "text": "Thus , in-house LED phototherapy equipment has been developed .", "sentence_id": 2}
+{"abstract_id": "24511717", "label": "objective", "text": "To compare efficacy between in-house LED to conventional phototherapy equipment in the treatment of neonatal hyperbilirubinemia at Mae Sot Hospital .", "sentence_id": 3}
+{"abstract_id": "24511717", "label": "methods", "text": "This was a randomized controlled trial .", "sentence_id": 4}
+{"abstract_id": "24511717", "label": "methods", "text": "Fifty newborns with hyperbilirubinemia were allocated to LED phototherapy group and conventional group .", "sentence_id": 5}
+{"abstract_id": "24511717", "label": "methods", "text": "Baseline characteristics were compared and analyzed by descriptive statistics , exact probability and student t-test , and change in serum bilirubin level was analyzed by multilevel regression analysis .", "sentence_id": 6}
+{"abstract_id": "24511717", "label": "results", "text": "There were @ patients in each of the two groups .", "sentence_id": 7}
+{"abstract_id": "24511717", "label": "results", "text": "The median duration of phototherapy in LED group was @ hours , whereas the conventional group required @ hours ( p < @ ) and the average serum bilirubin level in LED group decreased more rapidly than in conventional group ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24511717", "label": "results", "text": "Hyperthermia were found in @ infants from conventional group ( @ % ) compared to @ infants from LED group ( @ % ) ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24511717", "label": "conclusions", "text": "In-house LED phototherapy equipment is more effective than conventional phototherapy in the reduction of serum bilirubin level and occurrence of hyperthermia during treatment is less .", "sentence_id": 10}
+{"abstract_id": "25072098", "label": "background", "text": "The CHRNA@-CHRNA@-CHRNB@ locus is associated with self-reported smoking behavior and also harbors the strongest genetic associations with chronic obstructive pulmonary disease ( COPD ) and lung cancer .", "sentence_id": 0}
+{"abstract_id": "25072098", "label": "background", "text": "Because the associations with lung disease remain after adjustment for self-reported smoking behaviors , it has been asserted that CHRNA@-CHRNA@-CHRNB@ variants increase COPD and lung cancer susceptibility independently of their effects on smoking .", "sentence_id": 1}
+{"abstract_id": "25072098", "label": "objective", "text": "To compare the genetic associations of exhaled carbon monoxide ( CO ) , a biomarker of current cigarette exposure , with self-reported smoking behaviors .", "sentence_id": 2}
+{"abstract_id": "25072098", "label": "methods", "text": "A total of @,@ European American and @ African American current smokers recruited into smoking cessation studies were assessed for CO at intake before smoking cessation .", "sentence_id": 3}
+{"abstract_id": "25072098", "label": "methods", "text": "DNA samples were genotyped using the Illumina Omni@ @ microarray .", "sentence_id": 4}
+{"abstract_id": "25072098", "label": "methods", "text": "Genetic associations with CO and smoking behaviors ( cigarettes smoked per day , Fagerstrom test for nicotine dependence ) were studied .", "sentence_id": 5}
+{"abstract_id": "25072098", "label": "results", "text": "Variants in the CHRNA@-CHRNA@-CHRNB@ locus , including rs@ , a nonsynonymous variant in CHRNA@ , are genomewide association study-significantly associated with CO ( = @ ; @ % confidence interval -LSB- CI -RSB- , @-@ @ ; P = @ @ ( -@ ) ) , and this association remains strong after adjusting for smoking behavior ( = @ ; @ % CI , @-@ @ ; P = @ @ ( -@ ) ) .", "sentence_id": 6}
+{"abstract_id": "25072098", "label": "results", "text": "The correlation between CO and cigarettes per day is statistically significantly lower ( z = @ ; P = @ @ ( -@ ) ) in African Americans ( r = @ ; @ % CI , @-@ @ ; P = @ ) than in European-Americans ( r = @ ; @ % CI , @-@ @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25072098", "label": "conclusions", "text": "Exhaled CO , a biomarker that is simple to measure , captures aspects of cigarette smoke exposure in current smokers beyond the number of cigarettes smoked per day .", "sentence_id": 8}
+{"abstract_id": "25072098", "label": "conclusions", "text": "Behavioral measures of smoking are therefore insufficient indices of cigarette smoke exposure , suggesting that genetic associations with COPD or lung cancer that persist after adjusting for self-reported smoking behavior may still reflect genetic effects on smoking exposure .", "sentence_id": 9}
+{"abstract_id": "24862029", "label": "objective", "text": "The core clinical and neuropathological feature of the autosomal dominant spinocerebellar ataxias ( SCAs ) is cerebellar degeneration .", "sentence_id": 0}
+{"abstract_id": "24862029", "label": "objective", "text": "Mutations in the known genes explain only @ % to @ % of SCA cases .", "sentence_id": 1}
+{"abstract_id": "24862029", "label": "objective", "text": "To date , no effective treatments exist , and the knowledge of drug-treatable molecular pathways is limited .", "sentence_id": 2}
+{"abstract_id": "24862029", "label": "objective", "text": "The examination of overlapping mechanisms and the interpretation of how ataxia genes interact will be important in the discovery of potential disease-modifying agents .", "sentence_id": 3}
+{"abstract_id": "24862029", "label": "objective", "text": "To address the possible relationships among known SCA genes , predict their functions , identify overlapping pathways , and provide a framework for candidate gene discovery using whole-transcriptome expression data .", "sentence_id": 4}
+{"abstract_id": "24862029", "label": "methods", "text": "We have used a systems biology approach based on whole-transcriptome gene expression analysis .", "sentence_id": 5}
+{"abstract_id": "24862029", "label": "methods", "text": "As part of the United Kingdom Brain Expression Consortium , we analyzed the expression profile of @ brain samples obtained from @ neuropathologically healthy individuals ( @ distinct brain regions each ) .", "sentence_id": 6}
+{"abstract_id": "24862029", "label": "methods", "text": "Weighted gene coexpression network analysis was used to cluster @ SCA genes into gene coexpression modules in an unsupervised manner .", "sentence_id": 7}
+{"abstract_id": "24862029", "label": "methods", "text": "The overrepresentation of SCA transcripts in modules identified in the cerebellum was assessed .", "sentence_id": 8}
+{"abstract_id": "24862029", "label": "methods", "text": "Enrichment analysis was performed to infer the functions and molecular pathways of genes in biologically relevant modules .", "sentence_id": 9}
+{"abstract_id": "24862029", "label": "methods", "text": "Molecular functions and mechanisms implicating SCA genes , as well as lists of relevant coexpressed genes as potential candidates for novel SCA causative or modifier genes .", "sentence_id": 10}
+{"abstract_id": "24862029", "label": "results", "text": "Two cerebellar gene coexpression modules were statistically enriched in SCA transcripts ( P = @ for the tan module and P = @-@ for the light yellow module ) and contained established granule and Purkinje cell markers , respectively .", "sentence_id": 11}
+{"abstract_id": "24862029", "label": "results", "text": "One module includes genes involved in the ubiquitin-proteasome system and contains SCA genes usually associated with a complex phenotype , while the other module encloses many genes important for calcium homeostasis and signaling and contains SCA genes associated mostly with pure ataxia .", "sentence_id": 12}
+{"abstract_id": "24862029", "label": "conclusions", "text": "Using normal gene expression in the human brain , we identified significant cell types and pathways in SCA pathogenesis .", "sentence_id": 13}
+{"abstract_id": "24862029", "label": "conclusions", "text": "The overrepresentation of genes involved in calcium homeostasis and signaling may indicate an important target for therapy in the future .", "sentence_id": 14}
+{"abstract_id": "24862029", "label": "conclusions", "text": "Furthermore , the gene networks provide new candidate genes for ataxias or novel genes that may be critical for cerebellar function .", "sentence_id": 15}
+{"abstract_id": "26003882", "label": "objective", "text": "To assess the effectiveness of supreme laryngeal mask airway ( SLMA ) over face mask ventilation for preventing need for endotracheal intubation at birth .", "sentence_id": 0}
+{"abstract_id": "26003882", "label": "methods", "text": "We report a prospective , randomized , parallel @:@ , unblinded , controlled trial .", "sentence_id": 1}
+{"abstract_id": "26003882", "label": "methods", "text": "After a short-term educational intervention on SLMA use , infants @-week gestation and/or expected birth weight @ g requiring positive pressure ventilation ( PPV ) at birth were randomized to resuscitation by SLMA or face mask .", "sentence_id": 2}
+{"abstract_id": "26003882", "label": "methods", "text": "The primary outcome was the success rate of the resuscitation devices ( SLMA or face mask ) defined as the achievement of an effective PPV preventing the need for endotracheal intubation .", "sentence_id": 3}
+{"abstract_id": "26003882", "label": "results", "text": "We enrolled @ patients ( @ in SLMA and @ in face mask group , respectively ) .", "sentence_id": 4}
+{"abstract_id": "26003882", "label": "results", "text": "Successful resuscitation rate was significantly higher with the SLMA compared with face mask ventilation ( @ % vs @ % ; P = @ ) .", "sentence_id": 5}
+{"abstract_id": "26003882", "label": "results", "text": "Apgar score at @ minutes was significantly higher in SLMA than in face mask group ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "26003882", "label": "results", "text": "Neonatal intensive care unit admission rate was significantly lower in SLMA than in face mask group ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "26003882", "label": "results", "text": "No complications related to the procedure occurred .", "sentence_id": 8}
+{"abstract_id": "26003882", "label": "conclusions", "text": "In newborns with gestational age @ weeks and/or expected birth weight @ g needing PPV at birth , the SLMA is more effective than face mask to prevent endotracheal intubation .", "sentence_id": 9}
+{"abstract_id": "26003882", "label": "conclusions", "text": "The SLMA is effective in clinical practice after a short-term educational intervention .", "sentence_id": 10}
+{"abstract_id": "25488088", "label": "objective", "text": "To determine the optimum mode of delivery for women in preterm breech labour at a gestational age of @ to @ weeks .", "sentence_id": 0}
+{"abstract_id": "25488088", "label": "methods", "text": "A multicentre randomised controlled trial .", "sentence_id": 1}
+{"abstract_id": "25488088", "label": "methods", "text": "Twenty-six hospitals in England , UK .", "sentence_id": 2}
+{"abstract_id": "25488088", "label": "methods", "text": "Women with a singleton breech fetus in spontaneous preterm labour between @ and @ completed weeks of gestation , with no clear indication for a caesarean section or vaginal breech delivery .", "sentence_id": 3}
+{"abstract_id": "25488088", "label": "methods", "text": "Random allocation to either ` intention to delivery vaginally ' or ` intention to deliver by caesarean section ' .", "sentence_id": 4}
+{"abstract_id": "25488088", "label": "methods", "text": "Perinatal mortality , neonatal morbidity , maternal morbidity and gestation at delivery .", "sentence_id": 5}
+{"abstract_id": "25488088", "label": "results", "text": "The trial was closed after @ months because of low recruitment , by which time substantial numbers of women had been in the eligible gestation period .", "sentence_id": 6}
+{"abstract_id": "25488088", "label": "results", "text": "Thirteen women from six hospitals were recruited .", "sentence_id": 7}
+{"abstract_id": "25488088", "label": "results", "text": "One infant , randomised to and delivered vaginally , was stillborn .", "sentence_id": 8}
+{"abstract_id": "25488088", "label": "results", "text": "Three fetal presentations were cephalic at delivery despite a diagnosis of breech presentation at trial entry .", "sentence_id": 9}
+{"abstract_id": "25488088", "label": "results", "text": "No formal statistical analysis was performed due to the small numbers .", "sentence_id": 10}
+{"abstract_id": "25488088", "label": "conclusions", "text": "No conclusions about the optimum mode of delivery for women in preterm labour with a fetus presenting by the breech can be drawn from this trial .", "sentence_id": 11}
+{"abstract_id": "25488088", "label": "conclusions", "text": "The low accrual rate was due to clinicians ' reluctance to randomise eligible women , reflecting the circumstances and nature of the trial .", "sentence_id": 12}
+{"abstract_id": "24304555", "label": "objective", "text": "This randomized controlled study tested the effectiveness of individualized activities , led by certified nursing assistants ( CNAs ) , to increase positive and reduce negative affect and behavior among nursing home residents with dementia .", "sentence_id": 0}
+{"abstract_id": "24304555", "label": "methods", "text": "Nursing home residents with mild to advanced dementia ( N = @ ) were randomly assigned to usual care ( UC , n = @ ) or @ of @ experimental conditions .", "sentence_id": 1}
+{"abstract_id": "24304555", "label": "methods", "text": "Residents in the attention control group ( AC , N = @ ) participated in standardized one-to-one activities with their CNAs .", "sentence_id": 2}
+{"abstract_id": "24304555", "label": "methods", "text": "Individualized Positive Psychosocial Intervention ( IPPI ) participants ( n = @ ) received a CNA-led activity matched to their interests and ability .", "sentence_id": 3}
+{"abstract_id": "24304555", "label": "methods", "text": "Outcomes were residents ' positive and negative affect and verbal and nonverbal behavior .", "sentence_id": 4}
+{"abstract_id": "24304555", "label": "results", "text": "The IPPI and AC groups experienced similar benefits-more pleasure , alertness , engagement , positive touch , and positive verbal behavior-compared with UC .", "sentence_id": 5}
+{"abstract_id": "24304555", "label": "results", "text": "The AC group displayed more anger , uncooperativeness , and very negative verbal behavior than UC or IPPI .", "sentence_id": 6}
+{"abstract_id": "24304555", "label": "conclusions", "text": "This study demonstrates the value of individualized activities for nursing home residents with dementia .", "sentence_id": 7}
+{"abstract_id": "24304555", "label": "conclusions", "text": "In a stringent test , residents were happier and less angry during a customized intervention compared with a standardized intervention .", "sentence_id": 8}
+{"abstract_id": "24304555", "label": "conclusions", "text": "Even brief individualized CNA-led activities bring pleasure to nursing home residents and constitute an effective strategy to enhance positive affect and engagement in persons with dementia .", "sentence_id": 9}
+{"abstract_id": "25773607", "label": "background", "text": "Evolocumab , a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type @ ( PCSK@ ) , significantly reduced low-density lipoprotein ( LDL ) cholesterol levels in short-term studies .", "sentence_id": 0}
+{"abstract_id": "25773607", "label": "background", "text": "We conducted two extension studies to obtain longer-term data .", "sentence_id": 1}
+{"abstract_id": "25773607", "label": "methods", "text": "In two open-label , randomized trials , we enrolled @ patients who had completed @ of @ phase @ or @ studies ( `` parent trials '' ) of evolocumab .", "sentence_id": 2}
+{"abstract_id": "25773607", "label": "methods", "text": "Regardless of study-group assignments in the parent trials , eligible patients were randomly assigned in a @:@ ratio to receive either evolocumab ( @ mg every @ weeks or @ mg monthly ) plus standard therapy or standard therapy alone .", "sentence_id": 3}
+{"abstract_id": "25773607", "label": "methods", "text": "Patients were followed for a median of @ months with assessment of lipid levels , safety , and ( as a prespecified exploratory analysis ) adjudicated cardiovascular events including death , myocardial infarction , unstable angina , coronary revascularization , stroke , transient ischemic attack , and heart failure .", "sentence_id": 4}
+{"abstract_id": "25773607", "label": "methods", "text": "Data from the two trials were combined .", "sentence_id": 5}
+{"abstract_id": "25773607", "label": "results", "text": "As compared with standard therapy alone , evolocumab reduced the level of LDL cholesterol by @ % , from a median of @ mg per deciliter to @ mg per deciliter ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25773607", "label": "results", "text": "Most adverse events occurred with similar frequency in the two groups , although neurocognitive events were reported more frequently in the evolocumab group .", "sentence_id": 7}
+{"abstract_id": "25773607", "label": "results", "text": "The risk of adverse events , including neurocognitive events , did not vary significantly according to the achieved level of LDL cholesterol .", "sentence_id": 8}
+{"abstract_id": "25773607", "label": "results", "text": "The rate of cardiovascular events at @ year was reduced from @ % in the standard-therapy group to @ % in the evolocumab group ( hazard ratio in the evolocumab group , @ ; @ % confidence interval , @ to @ ; P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25773607", "label": "conclusions", "text": "During approximately @ year of therapy , the use of evolocumab plus standard therapy , as compared with standard therapy alone , significantly reduced LDL cholesterol levels and reduced the incidence of cardiovascular events in a prespecified but exploratory analysis .", "sentence_id": 10}
+{"abstract_id": "25773607", "label": "conclusions", "text": "( Funded by Amgen ; OSLER-@ and OSLER-@ ClinicalTrials.gov numbers , NCT@ and NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24247812", "label": "background", "text": "Previous metoprolol studies in myocardial infarction patients were performed with immediate-release ( IR ) metoprolol .", "sentence_id": 0}
+{"abstract_id": "24247812", "label": "background", "text": "This study aims to evaluate if extended-release metoprolol CR/XL once daily gives a similar - blockade over @ h compared to multiple dosing of metoprolol IR .", "sentence_id": 1}
+{"abstract_id": "24247812", "label": "methods", "text": "After @ days of routine metoprolol treatment , @ patients with suspected acute myocardial infarction were randomized to open-label treatment with metoprolol IR ( @ mg four times daily or @ mg twice daily ) or metoprolol CR/XL @ mg once daily for @ days .", "sentence_id": 2}
+{"abstract_id": "24247812", "label": "results", "text": "Metoprolol CR/XL @ mg once daily gave more pronounced suppression of peak heart rate , with lower peak and less variation in peak to trough plasma levels .", "sentence_id": 3}
+{"abstract_id": "24247812", "label": "results", "text": "There were no differences in AUC between the CR/XL and IR formulations , although the trough plasma metoprolol levels were comparable for metoprolol CR/XL @ mg once daily and metoprolol IR @ mg four times daily , but lower for metoprolol IR @ mg twice daily .", "sentence_id": 4}
+{"abstract_id": "24247812", "label": "results", "text": "Both treatments were well tolerated .", "sentence_id": 5}
+{"abstract_id": "24247812", "label": "conclusions", "text": "Metoprolol CR/XL @ mg once daily showed lower peak and less variation in peak to trough plasma levels compared to multiple dosing of metoprolol IR with the same AUC .", "sentence_id": 6}
+{"abstract_id": "24247812", "label": "conclusions", "text": "This was accompanied by a more uniform - blockade over time , which was reflected by heart rate , and a more pronounced suppression of peak heart rate with similar tolerability .", "sentence_id": 7}
+{"abstract_id": "24247812", "label": "conclusions", "text": "This suggests metoprolol CR/XL may be used as an alternative to metoprolol IR in patients with myocardial infarction .", "sentence_id": 8}
+{"abstract_id": "25224610", "label": "background", "text": "Antiretroviral ( ARV ) - based pre-exposure prophylaxis ( PrEP ) is a promising new HIV prevention strategy .", "sentence_id": 0}
+{"abstract_id": "25224610", "label": "background", "text": "However , variable levels of adherence have yielded mixed results across several PrEP trials and populations .", "sentence_id": 1}
+{"abstract_id": "25224610", "label": "background", "text": "It is not clear how taking ARV - traditionally used for HIV treatment - is perceived and how that perception may affect the use of these products as preventives .", "sentence_id": 2}
+{"abstract_id": "25224610", "label": "background", "text": "We explored the views and experiences of VOICE participants , their male partners and community members regarding the use of ARV as PrEP in the VOICE trial and the implications of these shared meanings for adherence .", "sentence_id": 3}
+{"abstract_id": "25224610", "label": "methods", "text": "VOICE-C was a qualitative ancillary study conducted at the Johannesburg site of VOICE , a multisite , double-blind , placebo-controlled randomised trial testing tenofovir gel , oral tenofovir and oral Truvada for HIV PrEP .", "sentence_id": 4}
+{"abstract_id": "25224610", "label": "methods", "text": "We interviewed @ randomly selected female VOICE participants , @ male partners and @ community members through in-depth interviews , serial ethnography , or focus group discussions .", "sentence_id": 5}
+{"abstract_id": "25224610", "label": "methods", "text": "All interviews were audiotaped , transcribed , translated and coded thematically for analysis .", "sentence_id": 6}
+{"abstract_id": "25224610", "label": "results", "text": "The concept of ARV for prevention was understood to varying degrees across all study groups .", "sentence_id": 7}
+{"abstract_id": "25224610", "label": "results", "text": "A majority of VOICE participants understood that the products contained ARV , more so for the tablets than for the gel .", "sentence_id": 8}
+{"abstract_id": "25224610", "label": "results", "text": "Although participants knew they were HIV negative , ARV was associated with illness .", "sentence_id": 9}
+{"abstract_id": "25224610", "label": "results", "text": "Male partners and community members echoed these sentiments , highlighting confusion between treatment and prevention .", "sentence_id": 10}
+{"abstract_id": "25224610", "label": "results", "text": "Concerned that they would be mistakenly identified as HIV positive , VOICE participants often concealed use of or hid their study products .", "sentence_id": 11}
+{"abstract_id": "25224610", "label": "results", "text": "This occasionally led to relationship conflicts or early trial termination .", "sentence_id": 12}
+{"abstract_id": "25224610", "label": "results", "text": "HIV stigma and its association with ARV , especially the tablets , was articulated in rumour and gossip in the community , the workplace and the household .", "sentence_id": 13}
+{"abstract_id": "25224610", "label": "results", "text": "Although ARV were recognised as potent and beneficial medications , transforming the AIDS body from sickness to health , they were regarded as potentially harmful for those uninfected .", "sentence_id": 14}
+{"abstract_id": "25224610", "label": "conclusions", "text": "VOICE participants and others in the trial community struggled to conceptualise the idea of using ARV for prevention .", "sentence_id": 15}
+{"abstract_id": "25224610", "label": "conclusions", "text": "This possibly influenced willingness to adopt ARV-based prevention in the VOICE clinical trial .", "sentence_id": 16}
+{"abstract_id": "25224610", "label": "conclusions", "text": "Greater investments should be made to increase community understanding of ARV for prevention and to mitigate pervasive HIV stigma .", "sentence_id": 17}
+{"abstract_id": "24813065", "label": "objective", "text": "Specific genetic or biological markers may predict inadequate response to therapy for major depressive disorder ( MDD ) .", "sentence_id": 0}
+{"abstract_id": "24813065", "label": "objective", "text": "The objective of the current post hoc analysis was to evaluate the effect of specific biological and genetic markers on the antidepressant efficacy of adjunctive L-methylfolate @ mg versus placebo from a trial of inadequate responders to selective serotonin reuptake inhibitors ( SSRIs ) .", "sentence_id": 1}
+{"abstract_id": "24813065", "label": "methods", "text": "The double-blind , randomized , placebo-controlled trial used the sequential parallel comparison design .", "sentence_id": 2}
+{"abstract_id": "24813065", "label": "methods", "text": "Outpatients with SSRI-resistant MDD ( DSM-IV criteria ) received L-methylfolate @ mg/d for @ days , placebo for @ days followed by L-methylfolate @ mg/d for @ days , or placebo for @ days .", "sentence_id": 3}
+{"abstract_id": "24813065", "label": "methods", "text": "The effects of baseline levels of select biological and genetic markers individually and combined on treatment response to L-methylfolate versus placebo were evaluated ; the primary response measure was the @-Item Hamilton Depression Rating Scale ( HDRS-@ ) .", "sentence_id": 4}
+{"abstract_id": "24813065", "label": "methods", "text": "The first patient was enrolled July @ , @ , and the last patient completed April @ , @ .", "sentence_id": 5}
+{"abstract_id": "24813065", "label": "results", "text": "Seventy-five patients were enrolled .", "sentence_id": 6}
+{"abstract_id": "24813065", "label": "results", "text": "Patients with specific biological ( body mass index @ kg/m , elevated plasma levels of high-sensitivity C-reactive protein or @-hydroxy-@-nonenal , low S-adenosylmethionine/S-adenosylhomocysteine ratio ) and genetic markers at baseline had significantly ( P @ ) greater pooled mean change from baseline on the HDRS-@ with L-methylfolate versus placebo .", "sentence_id": 7}
+{"abstract_id": "24813065", "label": "results", "text": "Pooled mean change from baseline on the Clinical Global Impressions-Severity of Illness scale was significantly ( P < @ ) greater with L-methylfolate versus placebo for most genetic markers .", "sentence_id": 8}
+{"abstract_id": "24813065", "label": "results", "text": "Most combinations of baseline biological and genetic markers predicted significantly ( P @ ) greater reductions in pooled mean change from baseline in HDRS-@ scores with L-methylfolate versus placebo .", "sentence_id": 9}
+{"abstract_id": "24813065", "label": "conclusions", "text": "Biomarkers associated with inflammation or metabolism and genomic markers associated with L-methylfolate synthesis and metabolism may identify patients with SSRI-resistant depression who are responsive to adjunctive therapy with L-methylfolate @ mg .", "sentence_id": 10}
+{"abstract_id": "24813065", "label": "conclusions", "text": "Confirmatory studies are needed .", "sentence_id": 11}
+{"abstract_id": "25543421", "label": "objective", "text": "To compare the efficacy difference in treatment of depression in breast cancer between the combined therapy of acupuncture and auricular acupressure and western medication .", "sentence_id": 0}
+{"abstract_id": "25543421", "label": "methods", "text": "Sixty patients were randomized into an observation group and a control group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "25543421", "label": "methods", "text": "In the observation group , the combined therapy of acupuncture and auricular acupressure was adopted .", "sentence_id": 2}
+{"abstract_id": "25543421", "label": "methods", "text": "The main acupoints of acupuncture were Hegu ( LI @ ) , Tai-chong ( LR @ ) , Baihui ( GV @ ) , Zusanli ( ST @ ) , Qihai ( CV @ ) , etc. .", "sentence_id": 3}
+{"abstract_id": "25543421", "label": "methods", "text": "The supplementary acupoints were combined according to the syndrome differentiation .", "sentence_id": 4}
+{"abstract_id": "25543421", "label": "methods", "text": "The treatment was given once every day , @ treatments a week , at the interval of @ days among weeks .", "sentence_id": 5}
+{"abstract_id": "25543421", "label": "methods", "text": "The auricular acupressure was applied to gan ( CO@ , liver ) , pi ( CO@ , spleen ) , neifenmi ( CO@ , endocrine ) , etc. , once every @ days , on each side in one treatment .", "sentence_id": 6}
+{"abstract_id": "25543421", "label": "methods", "text": "In the control group , fluoxetine hydrochloride capsules were prescribed for oral administration , @ mg , once a day .", "sentence_id": 7}
+{"abstract_id": "25543421", "label": "methods", "text": "The Hamilton depression rating scale ( HAMD ) was used to assess the disease severity and efficacy before treatment , in @ and @ weeks of treatment separately .", "sentence_id": 8}
+{"abstract_id": "25543421", "label": "methods", "text": "HAMD factor changes were observed before treatment and at the end of the @th week .", "sentence_id": 9}
+{"abstract_id": "25543421", "label": "methods", "text": "The Asberg antidepressants scale ( SERS ) was applied to safety assessment .", "sentence_id": 10}
+{"abstract_id": "25543421", "label": "results", "text": "The total effective rate was @ % ( @/@ ) in the observation group , better than @ % ( @/@ ) in the control group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "25543421", "label": "results", "text": "At the end of the @th and @th weeks , HAMD scores were all reduced apparently in the two groups ( all P < @ ) .", "sentence_id": 12}
+{"abstract_id": "25543421", "label": "results", "text": "At the end of the @th week , the scores of the HAMD factor @ ( anxiety/somatic system ) , factor @ ( retardation ) and factor @ ( sleep disturbance ) were all reduced as compared with those before treatment in the two groups ( all P < @ ) ; the results in the observation group were better than those in the control group ( P < @ , P < @ ) .", "sentence_id": 13}
+{"abstract_id": "25543421", "label": "results", "text": "SERS score in the observation group was lower obviously than that in the control group ( P < @ ) .", "sentence_id": 14}
+{"abstract_id": "25543421", "label": "conclusions", "text": "The combined therapy of acupuncture and auricular acupressure achieves the antidepression effect in treatment of depression in breast cancer and has less side effects and high safety .", "sentence_id": 15}
+{"abstract_id": "25543421", "label": "conclusions", "text": "The efficacy is superior to fluoxetine hydrochloride capsules .", "sentence_id": 16}
+{"abstract_id": "24449631", "label": "objective", "text": "To compare intercellular adhesion molecule-@ ( ICAM-@ ) and vascular cell adhesion molecule-@ ( VCAM-@ ) serum levels between patients with stable ( SAP ) and unstable angina pectoris ( USAP ) undergoing coronary angiography ( CAG ) , investigate effects of CAG on ICAM-@ , VCAM-@ levels in SAP , USAP patients ; probable different effects of non-ionic radiocontrast media ( RCM ) , iso-osmotic iodixanol and low osmolar iopamidol , on these adhesion molecules ( AM ) .", "sentence_id": 0}
+{"abstract_id": "24449631", "label": "methods", "text": "In this randomized , prospective study , @ groups consisting of patients with SAP ( n = @ ) and USAP ( n = @ ) undergoing CAG were included .", "sentence_id": 1}
+{"abstract_id": "24449631", "label": "methods", "text": "For halves of each group iopamidol , for the other halves iodixanol were used as RCM , in turn for randomization .", "sentence_id": 2}
+{"abstract_id": "24449631", "label": "methods", "text": "The patients were divided into @ subgroups according to clinical presentations and used RCM ( SAP-iodixanol , SAP-iopamidol USAP-iodixanol , USAP-iopamidol ) .", "sentence_id": 3}
+{"abstract_id": "24449631", "label": "methods", "text": "ICAM-@ , VCAM-@ levels were measured just before and @ hours after CAG .", "sentence_id": 4}
+{"abstract_id": "24449631", "label": "methods", "text": "Repeated measurements were compared with two-way ANOVA test .", "sentence_id": 5}
+{"abstract_id": "24449631", "label": "results", "text": "Baseline VCAM-@ concentration was higher in USAP group than SAP group ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24449631", "label": "results", "text": "ICAM-@ , VCAM-@ concentrations increased significantly following CAG in SAP , USAP groups .", "sentence_id": 7}
+{"abstract_id": "24449631", "label": "results", "text": "ICAM-@ , VCAM-@ concentration increments ; did n't reach statistical significance in SAP-iodixanol subgroup , reached a borderline significance in SAP-iopamidol subgroup ( p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24449631", "label": "results", "text": "In USAP-iodixanol subgroup ; only VCAM-@ ( p < @ ) , in USAP-iopamidol subgroup ; ICAM-@ ( p = @ ) , VCAM-@ ( p = @ ) levels increased significantly following CAG .", "sentence_id": 9}
+{"abstract_id": "24449631", "label": "results", "text": "No complication was observed .", "sentence_id": 10}
+{"abstract_id": "24449631", "label": "conclusions", "text": "To our knowledge , this is the first study indicating ICAM-@ , VCAM-@ inducing effect of CAG in patients with SAP , USAP and differential effects of iodixanol and iopamidol on ICAM-@ , VCAM-@ serum levels .", "sentence_id": 11}
+{"abstract_id": "24449631", "label": "conclusions", "text": "Further studies are needed to clarify the effects of CAG and different RCM on vascular inflammation , vessel injury , serum AM levels and their clinical significance .", "sentence_id": 12}
+{"abstract_id": "24449631", "label": "conclusions", "text": "This study should be taken as a pilot , hypothesis-generating study .", "sentence_id": 13}
+{"abstract_id": "24484688", "label": "background", "text": "The subcutaneous ( SC ) route has recently emerged as a rehydration method with potential advantages in the geriatric population .", "sentence_id": 0}
+{"abstract_id": "24484688", "label": "background", "text": "Nevertheless , little is known about its application during hospitalization .", "sentence_id": 1}
+{"abstract_id": "24484688", "label": "background", "text": "The objective of the present study is to evaluate the subcutaneous non-inferiority efficacy in hydration against the intravenous ( IV ) route in elderly patients with dehydration .", "sentence_id": 2}
+{"abstract_id": "24484688", "label": "methods", "text": "A prospective , randomized and controlled interventional trial of patients @ years and older admitted to an Acute Geriatric Unit with mild to moderate dehydration and oral intolerance , evaluating the non-inferiority of subcutaneous fluid therapy versus the intravenous route .", "sentence_id": 3}
+{"abstract_id": "24484688", "label": "methods", "text": "The intervention consisted of the administration of up to @ l/day/route for @ hours subcutaneous vs. intravenous , evaluating the variations in biochemical parameters ( urea , creatinine , osmolarity ) , clinical outcome , and route related complications .", "sentence_id": 4}
+{"abstract_id": "24484688", "label": "results", "text": "Sixty seven patients completed the study ( @ SC , age @ @ years , @ % women , vs. @ IV , @ @ , @ % women , with no significant differences ) .", "sentence_id": 5}
+{"abstract_id": "24484688", "label": "results", "text": "The amount of fluid administered per day by route was @ ml @ SC vs. @ ml @ IV , P = @ .", "sentence_id": 6}
+{"abstract_id": "24484688", "label": "results", "text": "During follow similar reductions were observed between groups without any statistical significance , with mean differences pre-postintervention of urea ( @ @ SC vs. @ @ IV , P = @ ) ; creatinine ( @ @ SC vs. @ @ IV , P = @ ) , and osmolarity ( @ @ SC vs. @ @ IV , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24484688", "label": "results", "text": "Fewer catheter extraction episodes were observed in the SC group , which also was the group most prone to peri-clysis edema .", "sentence_id": 8}
+{"abstract_id": "24484688", "label": "conclusions", "text": "The efficacy of subcutaneous rehydration in elderly hospitalized patients with mild-moderate dehydration is not inferior to that obtained intravenously , and may even have additional advantages .", "sentence_id": 9}
+{"abstract_id": "25466509", "label": "background", "text": "Patients with metastatic colorectal cancer ( mCRC ) previously-treated with oxaliplatin benefit significantly from the addition of aflibercept to FOLFIRI in relation to overall survival , progression-free survival and response rate .", "sentence_id": 0}
+{"abstract_id": "25466509", "label": "methods", "text": "The results for efficacy and safety over the time course of the VEGF Trap ( aflibercept ) with irinotecan in colorectal cancer after failure of oxaliplatin regimen trial were analysed based on data from @ patients randomised to receive FOLFIRI plus either aflibercept ( n = @ ) or placebo ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25466509", "label": "methods", "text": "Hazard ratios ( HR ) by @-month time period were estimated using a piecewise Cox proportional hazard model .", "sentence_id": 2}
+{"abstract_id": "25466509", "label": "methods", "text": "Severity of adverse events ( AEs ) was graded using National Cancer Institute Common Terminology Criteria , version @ .", "sentence_id": 3}
+{"abstract_id": "25466509", "label": "results", "text": "The estimated probabilities of survival were @ % versus @ % at @ months , @ % versus @ % at @ months and @ % versus @ % at @ months , for the aflibercept - and placebo-treated arms , respectively .", "sentence_id": 4}
+{"abstract_id": "25466509", "label": "results", "text": "The proportional improvement in the HR over time was consistent with the survival probability results ; survival at @ months was improved by @ % and almost doubled at @ months .", "sentence_id": 5}
+{"abstract_id": "25466509", "label": "results", "text": "The majority of worst-grade AEs occurred within the first four cycles of treatment and in a small percent of treatment cycles and were mostly reversible .", "sentence_id": 6}
+{"abstract_id": "25466509", "label": "results", "text": "Common chemotherapy - and anti-vascular epithelial growth factor ( VEGF ) - associated AEs occurred rarely and in a small proportion of cycles with the majority being of single occurrence .", "sentence_id": 7}
+{"abstract_id": "25466509", "label": "conclusions", "text": "The addition of aflibercept to FOLFIRI showed a continued and persistent improvement in overall survival over time in patients with mCRC .", "sentence_id": 8}
+{"abstract_id": "25466509", "label": "conclusions", "text": "Although grade @-@ AEs were more frequent in the aflibercept arm , they occurred in early treatment cycles and decreased sharply following initial presentation .", "sentence_id": 9}
+{"abstract_id": "25425504", "label": "background", "text": "Compared to American Whites , African Americans have a higher prevalence of type @ diabetes mellitus ( T@DM ) , experiencing poorer metabolic control and greater risks for complications and death .", "sentence_id": 0}
+{"abstract_id": "25425504", "label": "background", "text": "Patient-level factors , such as diabetes knowledge , self-management skills , empowerment , and perceived control , account for > @ % of the variance observed in outcomes between these racial groups .", "sentence_id": 1}
+{"abstract_id": "25425504", "label": "background", "text": "There is strong evidence that self-management interventions that include telephone-delivered diabetes education and skills training are effective at improving metabolic control in diabetes .", "sentence_id": 2}
+{"abstract_id": "25425504", "label": "background", "text": "Web-based home telemonitoring systems in conjunction with active care management are also effective ways to lower glycosylated hemoglobin A@c values when compared to standard care , and provide feedback to patients ; however , there are no studies in African Americans with poorly controlled T@DM that examine the use of technology-based feedback to tailor or augment diabetes education and skills training .", "sentence_id": 3}
+{"abstract_id": "25425504", "label": "background", "text": "This study provides a unique opportunity to address this gap in the literature .", "sentence_id": 4}
+{"abstract_id": "25425504", "label": "methods", "text": "We describe an ongoing @-year randomized clinical trial , which will test the efficacy of a technology-intensified diabetes education and skills training ( TIDES ) intervention in African Americans with poorly controlled T@DM .", "sentence_id": 5}
+{"abstract_id": "25425504", "label": "methods", "text": "Two hundred male and female AfricanAmerican participants , @ years of age or older and with a glycosylated hemoglobin A@c level @ % , will be randomized into one of two groups for @ weeks of telephone interventions : ( @ ) TIDES intervention group or ( @ ) a usual-care group .", "sentence_id": 6}
+{"abstract_id": "25425504", "label": "methods", "text": "Participants will be followed for @ months to ascertain the effect of the interventions on glycemic control .", "sentence_id": 7}
+{"abstract_id": "25425504", "label": "methods", "text": "Our primary hypothesis is that , among African Americans with poorly controlled T@DM , patients randomized to the TIDES intervention will have significantly greater reduction in glycosylated hemoglobin A@c at @ months of follow-up compared to the usual-care group .", "sentence_id": 8}
+{"abstract_id": "25425504", "label": "conclusions", "text": "Results from this study will add to the current literature examining how best to deliver diabetes education and skills training and provide important insight into effective strategies to improve metabolic control and hence reduce diabetes complications and mortality rates in African Americans with poorly controlled T@DM .", "sentence_id": 9}
+{"abstract_id": "25516028", "label": "objective", "text": "To compare the effects of different types of physical and mental activity on self-reported sleep quality over @ weeks in older adults with cognitive and sleep complaints .", "sentence_id": 0}
+{"abstract_id": "25516028", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 1}
+{"abstract_id": "25516028", "label": "methods", "text": "General community .", "sentence_id": 2}
+{"abstract_id": "25516028", "label": "methods", "text": "Seventy-two inactive community-dwelling older adults with self-reported sleep and cognitive problems ( mean age @ @ ; @ % women ) .", "sentence_id": 3}
+{"abstract_id": "25516028", "label": "methods", "text": "Random allocation to four arms using a two-by-two factorial design : aerobic + cognitive training , aerobic + educational DVD , stretching + cognitive training , and stretching + educational DVD arms ( @ min/d , @ d/wk for physical and mental activity for @ weeks ) .", "sentence_id": 4}
+{"abstract_id": "25516028", "label": "methods", "text": "Change in sleep quality using seven questions from the Sleep Disorders Questionnaire on the @ to @ National Health and Nutrition Examination Survey ( range @-@ , with higher scores reflecting worse sleep quality ) .", "sentence_id": 5}
+{"abstract_id": "25516028", "label": "methods", "text": "Analyses used intention-to-treat methods .", "sentence_id": 6}
+{"abstract_id": "25516028", "label": "results", "text": "Sleep quality scores did not differ at baseline , but there was a significant difference between the study arms in change in sleep quality over time ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25516028", "label": "results", "text": "Mean sleep quality scores improved significantly more in the stretching + educational DVD arm ( @ points ) than in the stretching + cognitive training ( @ points ) , aerobic + educational DVD ( @ points ) , or aerobic + cognitive training ( @ points ) arms ( all P < @ , corrected for multiple comparisons ) .", "sentence_id": 8}
+{"abstract_id": "25516028", "label": "results", "text": "Differences between arms were strongest for waking at night ( P = @ ) and taking sleep medications ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25516028", "label": "conclusions", "text": "Self-reported sleep quality improved significantly more with low-intensity physical and mental activities than with moderate - or high-intensity activities in older adults with self-reported cognitive and sleep difficulties .", "sentence_id": 10}
+{"abstract_id": "25516028", "label": "conclusions", "text": "Future longer-term studies with objective sleep measures are needed to corroborate these results .", "sentence_id": 11}
+{"abstract_id": "24385637", "label": "objective", "text": "The present study examined health and physical performance as mediators of the association between driving cessation and mortality among older residents of small and large cities .", "sentence_id": 0}
+{"abstract_id": "24385637", "label": "methods", "text": "Participants ( N = @,@ ) were from the Advanced Cognitive Training for Independent and Vital Elderly ( ACTIVE ) study .", "sentence_id": 1}
+{"abstract_id": "24385637", "label": "methods", "text": "Participants ' driving status and health were measured at baseline , and mortality rates were observed across the subsequent @ years .", "sentence_id": 2}
+{"abstract_id": "24385637", "label": "results", "text": "Overall , mortality risk was @ times higher for nondrivers versus drivers ; this relationship was significantly mediated by physical performance and social , physical , and general health .", "sentence_id": 3}
+{"abstract_id": "24385637", "label": "results", "text": "For large-city residents , mediation effects for all mediators were significant and complete .", "sentence_id": 4}
+{"abstract_id": "24385637", "label": "results", "text": "For small-city residents , only physical and general health were significant mediators , and these effects were partial .", "sentence_id": 5}
+{"abstract_id": "24385637", "label": "conclusions", "text": "Health difficulties that accompany or follow driving cessation may explain the association between driving cessation and mortality , particularly for residents of large cities , where alternative transportation options may be more numerous .", "sentence_id": 6}
+{"abstract_id": "24565103", "label": "objective", "text": "To determine whether modifying a plastic speculum with a flexible sheath would improve visualization and decrease pain during vaginal examination .", "sentence_id": 0}
+{"abstract_id": "24565103", "label": "methods", "text": "We conducted a prospective randomized controlled trial of @ women undergoing vaginal speculum examination at an outpatient obstetrics and gynecology faculty practice .", "sentence_id": 1}
+{"abstract_id": "24565103", "label": "methods", "text": "Patients underwent examination via a standardized technique with either a medium-sized plastic speculum ( standard ) or an identical speculum modified with a flexible polypropylene sheath ( sheathed ) .", "sentence_id": 2}
+{"abstract_id": "24565103", "label": "methods", "text": "Investigators recorded the percentage of the cervix visualized .", "sentence_id": 3}
+{"abstract_id": "24565103", "label": "methods", "text": "After speculum insertion , patients recorded pain using a @-cm visual analog scale .", "sentence_id": 4}
+{"abstract_id": "24565103", "label": "results", "text": "There were no substantial demographic differences between the standard ( n = @ ) and the sheathed ( n = @ ) groups .", "sentence_id": 5}
+{"abstract_id": "24565103", "label": "results", "text": "Investigators were able to visualize a significantly greater percentage of the cervix using the sheathed speculum compared with the standard speculum ( @ % @ % vs. @ % @ % ; P < @ ) , representing a @ % improvement in visualization , and were able to visualize the entire cervix in @ ( @ % ) patients when using the sheathed speculum compared with @ ( @ % ) patients undergoing standard speculum examination ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24565103", "label": "results", "text": "Patients undergoing examination with the sheathed speculum reported a nonsignificant decrease in pain scores ( @ vs @ ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24565103", "label": "conclusions", "text": "A sheathed speculum significantly improves visualization of the cervix , without compromising patient comfort .", "sentence_id": 8}
+{"abstract_id": "24565103", "label": "conclusions", "text": "ClinicalTrials.gov : NCT@ .", "sentence_id": 9}
+{"abstract_id": "25453519", "label": "objective", "text": "To assess change in physical functioning ( pain , range of motion ( ROM ) , strength , and endurance ) after @ weeks of therapeutic-yoga .", "sentence_id": 0}
+{"abstract_id": "25453519", "label": "methods", "text": "Planned analyses of data from a randomized pilot study of yoga after stroke .", "sentence_id": 1}
+{"abstract_id": "25453519", "label": "methods", "text": "University-based research laboratory .", "sentence_id": 2}
+{"abstract_id": "25453519", "label": "methods", "text": "People with chronic stroke ( N = @ ) randomized to therapeutic-yoga ( n = @ ) or wait-list control ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25453519", "label": "methods", "text": "@ sessions of therapeutic yoga ( twice a week/@ weeks ) .", "sentence_id": 4}
+{"abstract_id": "25453519", "label": "methods", "text": "Yoga was delivered in a standardized and progressive format with postures , breathing , and meditation , and relaxation in sitting , standing , and supine .", "sentence_id": 5}
+{"abstract_id": "25453519", "label": "methods", "text": "Pain was assessed with the PEG , a @-item functional measure of the interference of pain .", "sentence_id": 6}
+{"abstract_id": "25453519", "label": "methods", "text": "ROM included neck and hip active and passive ROM measurements ) .", "sentence_id": 7}
+{"abstract_id": "25453519", "label": "methods", "text": "Upper and lower extremity strength were assessed with the arm curl test and chair-to-stand test , respectively .", "sentence_id": 8}
+{"abstract_id": "25453519", "label": "methods", "text": "Endurance was assessed with the @-minute walk and modified @-min step test .", "sentence_id": 9}
+{"abstract_id": "25453519", "label": "results", "text": "After a Bonferroni Correction , pain , neck ROM , hip passive ROM , upper extremity strength , and the @-min walk scores all significantly improved after @ weeks of engaging in yoga .", "sentence_id": 10}
+{"abstract_id": "25453519", "label": "results", "text": "No changes occurred in the wait-list control group .", "sentence_id": 11}
+{"abstract_id": "25453519", "label": "conclusions", "text": "A group therapeutic-yoga intervention may improve multiple aspects of physical functioning after stroke .", "sentence_id": 12}
+{"abstract_id": "25453519", "label": "conclusions", "text": "Such an intervention may be complementary to traditional rehabilitation .", "sentence_id": 13}
+{"abstract_id": "24920942", "label": "background", "text": "Prophylactic fluid preloading before spinal anesthesia has been a routine procedure to prevent maternal hypotension during cesarean delivery .", "sentence_id": 0}
+{"abstract_id": "24920942", "label": "background", "text": "Unlike colloid , timing of infusion of crystalloid may be important because of its short stay in intravascular space .", "sentence_id": 1}
+{"abstract_id": "24920942", "label": "background", "text": "We hypothesized that crystalloid loading just after intrathecal injection compared to preload would be more effective in preventing maternal hypotension .", "sentence_id": 2}
+{"abstract_id": "24920942", "label": "methods", "text": "In this prospective controlled study , sixty parturients were randomized to receive @ml/kg of crystalloid before ( preload group ) or after ( coload group ) intrathecal drug injection for spinal anesthesia .", "sentence_id": 3}
+{"abstract_id": "24920942", "label": "methods", "text": "Hypotension was defined if systolic arterial pressure decreased below @ % of baseline and ephedrine was administered to treat hypotension .", "sentence_id": 4}
+{"abstract_id": "24920942", "label": "methods", "text": "The incidence of hypotension and the total dose of ephedrine were checked .", "sentence_id": 5}
+{"abstract_id": "24920942", "label": "methods", "text": "Blood pressure , heart rate and nausea before childbirth were assessed .", "sentence_id": 6}
+{"abstract_id": "24920942", "label": "methods", "text": "Neonatal outcomes were evaluated with Apgar scores and umbilical blood gas analysis .", "sentence_id": 7}
+{"abstract_id": "24920942", "label": "results", "text": "The incidence of hypotension was lower in the coload group compared to the preload group ( @ % vs. @ % , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24920942", "label": "results", "text": "The blood pressure showed the bigger drop during spinal anesthesia in the preload group ( @ vs. @mmHg , P = @ ) and smaller dose of ephedrine was required in the coload group ( @ -LSB- @-@ -RSB- vs. @ -LSB- @-@ -RSB- mg , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24920942", "label": "results", "text": "The incidence of nausea was also lower in the coload group ( @ % vs. @ % , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24920942", "label": "results", "text": "Neonatal outcome measures were comparable between two groups .", "sentence_id": 11}
+{"abstract_id": "24920942", "label": "conclusions", "text": "In case of using crystalloids for cesarean delivery , coload is more effective than preload for the prevention of maternal hypotension after spinal anesthesia .", "sentence_id": 12}
+{"abstract_id": "24660827", "label": "objective", "text": "To evaluate the effects of benzalkonium chloride ( BAK ) on the blood-aqueous ( BAB ) and blood-retinal barriers ( BRB ) of pseudophakic eyes .", "sentence_id": 0}
+{"abstract_id": "24660827", "label": "methods", "text": "Prospective , randomized , investigator-masked , comparative study .", "sentence_id": 1}
+{"abstract_id": "24660827", "label": "methods", "text": "Patients were randomly assigned to preservative-free artificial tears or BAK-preserved artificial tears .", "sentence_id": 2}
+{"abstract_id": "24660827", "label": "methods", "text": "One drop of artificial tears was instilled @ times a day in the study eye , starting the day after randomization for @ days .", "sentence_id": 3}
+{"abstract_id": "24660827", "label": "methods", "text": "Anterior chamber flare was assessed by a laser flare meter ( LFM ) and macular thickness measurements were obtained with optical coherence tomography , before , @ , and @ days after randomization .", "sentence_id": 4}
+{"abstract_id": "24660827", "label": "results", "text": "A total of @ healthy eyes of @ pseudophakic volunteers were recruited .", "sentence_id": 5}
+{"abstract_id": "24660827", "label": "results", "text": "There were no significant differences regarding demographics ( age , gender , and race distributions ) and clinical characteristics ( eye , mean intraocular pressure , and mean best-corrected visual acuity ) between the @ groups ( P > @ ) .", "sentence_id": 6}
+{"abstract_id": "24660827", "label": "results", "text": "No significant differences in baseline mean LFM values were observed ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24660827", "label": "results", "text": "However , we detected a statistically significant increase in mean LFM measurements in the BAK-preserved group ( @ @ ph/ms ) ( P = @ ) after @ days .", "sentence_id": 8}
+{"abstract_id": "24660827", "label": "results", "text": "After @ days , the BAK-preserved group maintained significantly higher flare values ( @ @ ph/ms ) compared with baseline ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24660827", "label": "results", "text": "On the other hand , the preservative-free group showed mean flare values of @ @ ph/ms , not significantly different from those obtained at baseline ( P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24660827", "label": "results", "text": "We observed no statistically significant change in macular thickness measurements at days @ and @ in either group ( P > @ ) .", "sentence_id": 11}
+{"abstract_id": "24660827", "label": "results", "text": "Cystoid macular edema was not detected in this series .", "sentence_id": 12}
+{"abstract_id": "24660827", "label": "conclusions", "text": "Our results suggest that a short-term exposure to BAK can cause disruption of the BAB , without altering the BRB in pseudophakic eyes .", "sentence_id": 13}
+{"abstract_id": "25749502", "label": "objective", "text": "Patients with decompensated cirrhosis have significantly reduced survival without liver transplantation .", "sentence_id": 0}
+{"abstract_id": "25749502", "label": "objective", "text": "Granulocyte colony-stimulating factor ( G-CSF ) has been shown to increase survival in patients with acute-on-chronic liver failure , and erythropoietin promoted hepatic regeneration in animal studies .", "sentence_id": 1}
+{"abstract_id": "25749502", "label": "objective", "text": "We performed a double-blind , randomized , placebo-controlled trial to determine whether co-administration of these growth factors improved outcomes for patients with advanced cirrhosis .", "sentence_id": 2}
+{"abstract_id": "25749502", "label": "methods", "text": "In a prospective study , consecutive patients with decompensated cirrhosis seen at the Institute of Liver and Biliary Sciences , New Delhi ( from May @ through June @ ) were randomly assigned to groups given subcutaneous G-CSF ( @ g/kg/d ) for @ days and then every third day ( @ total doses ) , along with subcutaneous darbopoietin ( @ mcg/wk ) for @ weeks ( GDP group , n = @ ) , or only placebos ( control group , n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25749502", "label": "methods", "text": "All patients also received standard medical therapy and were followed for @ months .", "sentence_id": 4}
+{"abstract_id": "25749502", "label": "methods", "text": "Histology was performed on liver biopsies .", "sentence_id": 5}
+{"abstract_id": "25749502", "label": "methods", "text": "The primary end point was survival at @ months .", "sentence_id": 6}
+{"abstract_id": "25749502", "label": "results", "text": "Baseline characteristics of patients were comparable ; alcohol intake was the most common etiology of cirrhosis .", "sentence_id": 7}
+{"abstract_id": "25749502", "label": "results", "text": "A higher proportion of patients in the GDP group than controls survived until @ months ( @ % vs @ % ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25749502", "label": "results", "text": "At @ months , Child-Turcotte Pugh scores were reduced by @ % in the GDP group and @ % in the control group , from baseline ( P = @ ) ; Model for End Stage Liver Disease scores were reduced by @ % and @ % , respectively ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25749502", "label": "results", "text": "The need for large-volume paracentesis was significantly reduced in GDP group , compared with controls ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "25749502", "label": "results", "text": "A lower proportion of patients in the GDP group developed septic shock ( @ % ) during follow-up compared with controls ( @ % ; P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25749502", "label": "results", "text": "No major adverse events were observed in either group .", "sentence_id": 12}
+{"abstract_id": "25749502", "label": "conclusions", "text": "In a single-center randomized trial , a significantly larger proportion of patients with decompensated cirrhosis given a combination of G-CSF and darbopoietin survived for @ months more than patients given only placebo .", "sentence_id": 13}
+{"abstract_id": "25749502", "label": "conclusions", "text": "The combination therapy also reduced liver severity scores and sepsis to a greater extent than placebo .", "sentence_id": 14}
+{"abstract_id": "25749502", "label": "conclusions", "text": "Clinicaltrials.gov ID : NCT@ .", "sentence_id": 15}
+{"abstract_id": "25584931", "label": "background", "text": "The abuse potential of prescription opioids is well established .", "sentence_id": 0}
+{"abstract_id": "25584931", "label": "background", "text": "This study compared positive , subjective drug effects of single , equal doses of biphasic immediate release ( IR ) / extended release ( ER ) hydrocodone bitartrate ( HB ) / acetaminophen ( acetyl-p-aminophenol -LSB- APAP -RSB- ) @ / @ mg tablets versus IR HB/APAP @ / @-mg tablets and placebo .", "sentence_id": 1}
+{"abstract_id": "25584931", "label": "methods", "text": "Healthy adult recreational users of prescription opioids entered this randomized , double-blind , double-dummy , active - and placebo-controlled , seven-way crossover study .", "sentence_id": 2}
+{"abstract_id": "25584931", "label": "methods", "text": "Participants received single , total doses of IR/ER HB/APAP @ / @ mg ( intact ; three active tablets ) and @/@ mg ( intact and crushed -LSB- encapsulated -RSB- ; six active tablets ) , IR HB/APAP @ / @ mg ( intact ; three active tablets ) and @/@ mg ( intact and crushed -LSB- encapsulated -RSB- ; six active tablets ) , and placebo .", "sentence_id": 3}
+{"abstract_id": "25584931", "label": "methods", "text": "Peak subjective effects ( E ( max ) ) ; time to peak effects ( TE ( max ) ) ; and area under the drug-effect curves for drug liking , high , and good drug effects were measured using visual analog scales .", "sentence_id": 4}
+{"abstract_id": "25584931", "label": "methods", "text": "Median values with @ % confidence interval ( CI ) were compared using analysis of variance .", "sentence_id": 5}
+{"abstract_id": "25584931", "label": "results", "text": "Among completers ( n = @ ) , IR/ER HB/APAP produced delayed and lower peak effects compared to equal doses of IR HB/APAP .", "sentence_id": 6}
+{"abstract_id": "25584931", "label": "results", "text": "Comparing intact tablets , the drug liking E ( max ) ( median -LSB- @ % CI -RSB- ) was significantly lower for IR/ER HB/APAP @/@ mg ( @ -LSB- @ , @ -RSB- ) than an equal dose of IR HB/APAP ( @ -LSB- @ , @ -RSB- ; difference , -@ -LSB- -@ , -@ -RSB- ; P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25584931", "label": "results", "text": "Similar results were observed for intact IR/ER HB/APAP and IR HB/APAP @ / @ mg .", "sentence_id": 8}
+{"abstract_id": "25584931", "label": "results", "text": "Crushing IR/ER HB/APAP @/@ mg delayed these effects compared with an equal dose of crushed IR HB/APAP and intact IR/ER HB/APAP .", "sentence_id": 9}
+{"abstract_id": "25584931", "label": "conclusions", "text": "IR/ER HB/APAP resulted in lower subjective positive drug effects than an equal dose of IR HB/APAP .", "sentence_id": 10}
+{"abstract_id": "25584931", "label": "conclusions", "text": "Crushing IR/ER HB/APAP also delayed the onset of subjective effects compared with intact IR/ER HB/APAP .", "sentence_id": 11}
+{"abstract_id": "25584931", "label": "conclusions", "text": "These findings suggest that biphasic IR/ER HB/APAP has lower abuse potential than IR HB/APAP in single equal doses .", "sentence_id": 12}
+{"abstract_id": "24313446", "label": "objective", "text": "To examine the effect of action and coping planning strategies in the adherence to medication among outpatients with coronary artery disease .", "sentence_id": 0}
+{"abstract_id": "24313446", "label": "background", "text": "Action and coping planning strategies are based on implementation intention , which requires self-regulation by the individual , to prioritize intentionally planned responses over learned or habitual ones , from daily routines to stressful situations .", "sentence_id": 1}
+{"abstract_id": "24313446", "label": "methods", "text": "Randomized controlled trial .", "sentence_id": 2}
+{"abstract_id": "24313446", "label": "methods", "text": "Participants ( n = @ ) were randomized into intervention ( use of action and coping planning strategies , n = @ ) or control ( usual care , n = @ ) groups .", "sentence_id": 3}
+{"abstract_id": "24313446", "label": "methods", "text": "The study was conducted between June @-May @ in two in-person visits : baseline and @-month follow-up .", "sentence_id": 4}
+{"abstract_id": "24313446", "label": "methods", "text": "Participants in the intervention group received telephone reinforcement between baseline and @-month follow-up .", "sentence_id": 5}
+{"abstract_id": "24313446", "label": "methods", "text": "Adherence to medication for cardioprotection and symptoms relief was evaluated by proportion of adherence , global measure of adherence evaluation and Morisky Self-Reported Measure of Medication Adherence Scale at both baseline and @-month follow-up .", "sentence_id": 6}
+{"abstract_id": "24313446", "label": "results", "text": "When using the measure of global measure of adherence , participants in the intervention group reported adherence to therapy more often than controls ( odds ratio = @ ) , but no statistically significant change was observed in the other two outcome measures .", "sentence_id": 7}
+{"abstract_id": "24313446", "label": "conclusions", "text": "This study has shown that individuals who use action and coping planning report higher adherence to drug treatment , when measured by the global adherence evaluation .", "sentence_id": 8}
+{"abstract_id": "24313446", "label": "conclusions", "text": "Further studies with longer follow-ups are needed to assess if the effect of planning strategies has long-term duration .", "sentence_id": 9}
+{"abstract_id": "24696051", "label": "objective", "text": "Intravitreal ranibizumab or bevacizumab are the most used drugs for treatment of neovascular age-related macular degeneration ( nAMD ) .", "sentence_id": 0}
+{"abstract_id": "24696051", "label": "objective", "text": "Repeated intravitreal injections represent an economic burden and may be associated with serious complications .", "sentence_id": 1}
+{"abstract_id": "24696051", "label": "objective", "text": "The aim of this study is to evaluate the number of needed injections within @ year of treatment .", "sentence_id": 2}
+{"abstract_id": "24696051", "label": "methods", "text": "@ patients over @ years of age with nAMD and visual acuity ( VA ) between @/@ and @/@ were included .", "sentence_id": 3}
+{"abstract_id": "24696051", "label": "methods", "text": "Scheduled visits and treatment were performed monthly for @ year .", "sentence_id": 4}
+{"abstract_id": "24696051", "label": "methods", "text": "After a loading dose of three intravitreal injections ( either ranibizumab = group @ or bevacizumab = group @ ) , an `` as needed '' regimen was performed .", "sentence_id": 5}
+{"abstract_id": "24696051", "label": "methods", "text": "Primary endpoint was a difference in the injection frequencies of ranibizumab and bevacizumab .", "sentence_id": 6}
+{"abstract_id": "24696051", "label": "methods", "text": "Secondary endpoints were best corrected visual acuity ( BCVA ) and central retinal thickness ( CRT ) .", "sentence_id": 7}
+{"abstract_id": "24696051", "label": "results", "text": "Difference in number of injections was not significant ( @ ( ranibizumab group ) vs. @ ( bevacizumab group ) , p = @ ) .", "sentence_id": 8}
+{"abstract_id": "24696051", "label": "results", "text": "Mean BCVA was @ letters after @ months if patients received ranibizumab ( p = @ ) and @ letters if patients received bevacizumab ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24696051", "label": "results", "text": "There was no statistical significance between the two groups ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24696051", "label": "results", "text": "The mean CRT did not differ significantly between groups after @ months ( @ m for ranibizumab , @ m for bevacizumab , p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24696051", "label": "conclusions", "text": "There was no difference in number of treatment , BCVA and CRT after @ year between ranibizumab and bevacizumab in patients with nAMD .", "sentence_id": 12}
+{"abstract_id": "24607004", "label": "background", "text": "Reintroduction of Variola major as an agent of bioterrorism remains a concern .", "sentence_id": 0}
+{"abstract_id": "24607004", "label": "background", "text": "Time to seroconversion and plaque reduction neutralizing antibody titers ( PRNT ) of @ or @ standard doses ( SD ) were compared to a single high dose ( HD ) of modified vaccinia Ankara ( MVA ) .", "sentence_id": 1}
+{"abstract_id": "24607004", "label": "methods", "text": "Ninety subjects were randomized @:@ to receive @ HD or @ SD of MVA subcutaneously on Days @ and @ in a placebo-controlled trial .", "sentence_id": 2}
+{"abstract_id": "24607004", "label": "methods", "text": "Serum was collected for PRNT and ELISA .", "sentence_id": 3}
+{"abstract_id": "24607004", "label": "methods", "text": "Subjects were followed for safety for the entire study .", "sentence_id": 4}
+{"abstract_id": "24607004", "label": "results", "text": "The HD was well-tolerated .", "sentence_id": 5}
+{"abstract_id": "24607004", "label": "results", "text": "Using Bavarian Nordic 's ELISA , subjects in both groups achieved seroconversion by Study Day @ ( HD ) and Day @ ( SD ) .", "sentence_id": 6}
+{"abstract_id": "24607004", "label": "results", "text": "Before second vaccination , the hazard rate of seroconverting for the HD group was @ times the SD group with a median time for seroconversion of @ days for both groups .", "sentence_id": 7}
+{"abstract_id": "24607004", "label": "results", "text": "The peak titer of one HD vaccine was superior to one dose of SD vaccine but inferior to the peak titer after the second dose of the SD vaccination regimen .", "sentence_id": 8}
+{"abstract_id": "24607004", "label": "results", "text": "Using Saint Louis University 's PRNT , peak titers were @ and @ for the HD and SD groups , respectively , prior to second vaccination .", "sentence_id": 9}
+{"abstract_id": "24607004", "label": "results", "text": "Non-inferiority of the SD group was not established .", "sentence_id": 10}
+{"abstract_id": "24607004", "label": "results", "text": "The proportions of positives were @ % ( @/@ ) and @ % ( @/@ ) for the HD and SD groups , respectively .", "sentence_id": 11}
+{"abstract_id": "24607004", "label": "results", "text": "The peak titer after two standard doses was superior to that of the HD .", "sentence_id": 12}
+{"abstract_id": "24607004", "label": "conclusions", "text": "HD MVA was safe and well-tolerated .", "sentence_id": 13}
+{"abstract_id": "24607004", "label": "conclusions", "text": "While the hazard rate for seroconverting was significantly higher in the HD group before second dose , the effect was small as the median time to seroconversion was identical .", "sentence_id": 14}
+{"abstract_id": "24607004", "label": "conclusions", "text": "When comparing PRNT , non-inferiority of one SD was not established and the peak titers were low for both groups .", "sentence_id": 15}
+{"abstract_id": "24607004", "label": "conclusions", "text": "The HD peak response was inferior to the standard two-dose regimen response based on ELISA and PRNT .", "sentence_id": 16}
+{"abstract_id": "25033137", "label": "objective", "text": "We examined whether and how an HIV prevention diffusion-based intervention spread throughout participants ' online social networks and whether changes in social network ties were associated with increased HIV prevention and testing behaviors .", "sentence_id": 0}
+{"abstract_id": "25033137", "label": "methods", "text": "We randomly assigned @ primarily racial/ethnic minority men who have sex with men ( MSM ) to receive peer-delivered HIV ( intervention ) or general health ( control ) information over @ weeks through closed Facebook groups .", "sentence_id": 1}
+{"abstract_id": "25033137", "label": "methods", "text": "We recorded participants ' public Facebook friend networks at baseline ( September @ ) and follow-up ( February @ ) , and assessed whether changes in network growth were associated with changes in health engagement and HIV testing .", "sentence_id": 2}
+{"abstract_id": "25033137", "label": "results", "text": "Within-group ties increased in both conditions from baseline to follow-up .", "sentence_id": 3}
+{"abstract_id": "25033137", "label": "results", "text": "Among the intervention group , we found a significant positive relation between increased network ties and using social media to discuss sexual behaviors .", "sentence_id": 4}
+{"abstract_id": "25033137", "label": "results", "text": "We found a positive trending relationship between increased network ties and likelihood of HIV testing , follow-up for test results , and participation in online community discussions .", "sentence_id": 5}
+{"abstract_id": "25033137", "label": "results", "text": "No significant differences were seen within control groups .", "sentence_id": 6}
+{"abstract_id": "25033137", "label": "conclusions", "text": "Among high-risk MSM , peer-led social media HIV prevention interventions can increase community cohesion .", "sentence_id": 7}
+{"abstract_id": "25033137", "label": "conclusions", "text": "These changes appear to be associated with increased HIV prevention and testing behaviors .", "sentence_id": 8}
+{"abstract_id": "25595151", "label": "objective", "text": "To assess the efficacy of recombinant human erythropoietin ( rhEPO ) in amyotrophic lateral sclerosis ( ALS ) .", "sentence_id": 0}
+{"abstract_id": "25595151", "label": "methods", "text": "Patients with probable laboratory-supported , probable or definite ALS were enrolled by @ Italian centres and randomly assigned ( @:@ ) to receive intravenous rhEPO @,@ IU or placebo fortnightly as add-on treatment to riluzole @mg daily for @months .", "sentence_id": 1}
+{"abstract_id": "25595151", "label": "methods", "text": "The primary composite outcome was survival , tracheotomy or > @h non-invasive ventilation ( NIV ) .", "sentence_id": 2}
+{"abstract_id": "25595151", "label": "methods", "text": "Secondary outcomes were ALSFRS-R , slow vital capacity ( sVC ) and quality of life ( ALSAQ-@ ) decline .", "sentence_id": 3}
+{"abstract_id": "25595151", "label": "methods", "text": "Tolerability was evaluated analysing adverse events ( AEs ) causing withdrawal .", "sentence_id": 4}
+{"abstract_id": "25595151", "label": "methods", "text": "The randomisation sequence was computer-generated by blocks , stratified by centre , disease severity ( ALSFRS-R cut-off score of @ ) and onset ( spinal or bulbar ) .", "sentence_id": 5}
+{"abstract_id": "25595151", "label": "methods", "text": "The main outcome analysis was performed in all randomised patients and by intention-to-treat for the entire population and patients stratified by severity and onset .", "sentence_id": 6}
+{"abstract_id": "25595151", "label": "methods", "text": "The study is registered , EudraCT @-@-@ .", "sentence_id": 7}
+{"abstract_id": "25595151", "label": "results", "text": "We randomly assigned @ patients , of whom @ ( @ rhEPO and @ placebo ) withdrew consent and @ ( placebo ) became ineligible ( retinal thrombosis , respiratory insufficiency , SOD@ mutation ) before receiving treatment ; @ receiving rhEPO and @ placebo were eligible for analysis .", "sentence_id": 8}
+{"abstract_id": "25595151", "label": "results", "text": "At @months , the annualised rate of death ( rhEPO @ , @ % CI @ to @ ; placebo : @ , CI @ to @ ) , tracheotomy or > @h NIV ( rhEPO @ , CI @ to @ ; placebo @ , CI @ to @ ) did not differ between groups , also after stratification by onset and ALSFRS-R at baseline .", "sentence_id": 9}
+{"abstract_id": "25595151", "label": "results", "text": "Withdrawal due to AE was @ % in rhEPO and @ % in placebo .", "sentence_id": 10}
+{"abstract_id": "25595151", "label": "results", "text": "No differences were found for secondary outcomes .", "sentence_id": 11}
+{"abstract_id": "25595151", "label": "conclusions", "text": "RhEPO @,@ IU fortnightly did not change the course of ALS .", "sentence_id": 12}
+{"abstract_id": "25038326", "label": "objective", "text": "To assess the safety and efficacy of dendritic cell vaccination in metastatic uveal melanoma .", "sentence_id": 0}
+{"abstract_id": "25038326", "label": "methods", "text": "Interventional case series .", "sentence_id": 1}
+{"abstract_id": "25038326", "label": "methods", "text": "We analyzed @ patients with metastatic uveal melanoma treated with dendritic cell vaccination .", "sentence_id": 2}
+{"abstract_id": "25038326", "label": "methods", "text": "Patients with metastatic uveal melanoma received at least @ vaccinations with autologous dendritic cells , professional antigen-presenting cells loaded with melanoma antigens gp@ and tyrosinase .", "sentence_id": 3}
+{"abstract_id": "25038326", "label": "methods", "text": "The main outcome measures were safety , immunologic response , and overall survival .", "sentence_id": 4}
+{"abstract_id": "25038326", "label": "results", "text": "Tumor-specific immune responses were induced with dendritic cell vaccination in @ ( @ % ) of @ patients .", "sentence_id": 5}
+{"abstract_id": "25038326", "label": "results", "text": "Dendritic cell-vaccinated patients showed a median overall survival with metastatic disease of @ months , relatively long compared with that reported in the literature .", "sentence_id": 6}
+{"abstract_id": "25038326", "label": "results", "text": "No severe treatment-related toxicities ( common toxicity criteria grade @ or @ ) were observed .", "sentence_id": 7}
+{"abstract_id": "25038326", "label": "conclusions", "text": "Dendritic cell vaccination is feasible and safe in metastatic uveal melanoma .", "sentence_id": 8}
+{"abstract_id": "25038326", "label": "conclusions", "text": "Dendritic cell-based immunotherapy is potent to enhance the host 's antitumor immunity against uveal melanoma in approximately one third of patients .", "sentence_id": 9}
+{"abstract_id": "25038326", "label": "conclusions", "text": "Compared with other prospective studies with similar inclusion criteria , dendritic cell vaccination may be associated with longer than average overall survival in patients with metastatic uveal melanoma .", "sentence_id": 10}
+{"abstract_id": "25239718", "label": "background", "text": "Catheter-associated urinary tract infection ( CAUTI ) risk is directly related to duration of indwelling urinary catheters ( IUCs ) , rising beyond @ days of catheterization .", "sentence_id": 0}
+{"abstract_id": "25239718", "label": "methods", "text": "We conducted a cluster randomized study in nonintensive care units of Nurses Improving Care for Healthsystem Elders ( NICHE ) hospitals .", "sentence_id": 1}
+{"abstract_id": "25239718", "label": "methods", "text": "Electronic surveillance data were used in an audit and feedback intervention for frontline nurses to reduce IUC duration .", "sentence_id": 2}
+{"abstract_id": "25239718", "label": "methods", "text": "Multivariable methods were used to identify the difference in average IUC duration and proportion of patients with IUC duration < @ days between patients in an early intervention group and a delayed intervention group , adjusting for patient , unit , and hospital characteristics .", "sentence_id": 3}
+{"abstract_id": "25239718", "label": "results", "text": "A total of @ units at @ NICHE hospitals reported @,@ adult patients with IUCs over @ months .", "sentence_id": 4}
+{"abstract_id": "25239718", "label": "results", "text": "Early and delayed intervention groups had important baseline differences in IUC utilization .", "sentence_id": 5}
+{"abstract_id": "25239718", "label": "results", "text": "Use of evidence-based CAUTI prevention measures increased during study participation .", "sentence_id": 6}
+{"abstract_id": "25239718", "label": "results", "text": "In multivariable analysis , the average IUC duration and proportion of patients with IUC duration < @ days were not improved in the early intervention group compared with the delayed intervention group .", "sentence_id": 7}
+{"abstract_id": "25239718", "label": "conclusions", "text": "The impact of the audit and feedback intervention was not significant despite the uptake of evidence-based CAUTI prevention practices .", "sentence_id": 8}
+{"abstract_id": "24867013", "label": "objective", "text": "Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction .", "sentence_id": 0}
+{"abstract_id": "24867013", "label": "objective", "text": "Management often involves endoscopic retrograde cholangiopancreatography ( ERCP ) with manometry and sphincterotomy .", "sentence_id": 1}
+{"abstract_id": "24867013", "label": "objective", "text": "To determine whether endoscopic sphincterotomy reduces pain and whether sphincter manometric pressure is predictive of pain relief .", "sentence_id": 2}
+{"abstract_id": "24867013", "label": "methods", "text": "Multicenter , sham-controlled , randomized trial involving @ patients with pain after cholecystectomy without significant abnormalities on imaging or laboratory studies , and no prior sphincter treatment or pancreatitis randomly assigned ( August @ , @-March @ , @ ) to undergo sphincterotomy or sham therapy at @ referral medical centers .", "sentence_id": 3}
+{"abstract_id": "24867013", "label": "methods", "text": "One-year follow-up was blinded .", "sentence_id": 4}
+{"abstract_id": "24867013", "label": "methods", "text": "The final follow-up visit was March @ , @ .", "sentence_id": 5}
+{"abstract_id": "24867013", "label": "methods", "text": "After ERCP , patients were randomized @:@ to sphincterotomy ( n = @ ) or sham ( n = @ ) irrespective of manometry findings .", "sentence_id": 6}
+{"abstract_id": "24867013", "label": "methods", "text": "Those randomized to sphincterotomy with elevated pancreatic sphincter pressures were randomized again ( @:@ ) to biliary or to both biliary and pancreatic sphincterotomies .", "sentence_id": 7}
+{"abstract_id": "24867013", "label": "methods", "text": "Seventy-two were entered into an observational study with conventional ERCP managemeny .", "sentence_id": 8}
+{"abstract_id": "24867013", "label": "methods", "text": "Success of treatment was defined as less than @ days of disability due to pain in the prior @ days both at months @ and @ after randomization , with no narcotic use and no further sphincter intervention .", "sentence_id": 9}
+{"abstract_id": "24867013", "label": "results", "text": "Twenty-seven patients ( @ % ; @ % CI , @ % -@ % ) in the sham treatment group vs @ ( @ % ; @ % CI , @ % -@ % ) in the sphincterotomy group experienced successful treatment ( adjusted risk difference , -@ % ; @ % CI , -@ % to -@ % ; P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24867013", "label": "results", "text": "Of the patients with pancreatic sphincter hypertension , @ ( @ % ; @ % CI , @ % -@ % ) who underwent dual sphincterotomy and @ ( @ % ; @ % CI , @ % -@ % ) who underwent biliary sphincterotomy alone experienced successful treatment .", "sentence_id": 11}
+{"abstract_id": "24867013", "label": "results", "text": "Thirty-seven treated patients ( @ % ; @ % CI ,@ % -@ % ) and @ patients ( @ % ; @ % CI , @ % -@ % ) in the sham group underwent repeat ERCP interventions ( P = @ ) .", "sentence_id": 12}
+{"abstract_id": "24867013", "label": "results", "text": "Manometry results were not associated with the outcome .", "sentence_id": 13}
+{"abstract_id": "24867013", "label": "results", "text": "No clinical subgroups appeared to benefit from sphincterotomy more than others .", "sentence_id": 14}
+{"abstract_id": "24867013", "label": "results", "text": "Pancreatitis occurred in @ patients ( @ % ) after primary sphincterotomies and in @ patients ( @ % ) in the sham group .", "sentence_id": 15}
+{"abstract_id": "24867013", "label": "results", "text": "Of the nonrandomized patients in the observational study group , @ ( @ % ; @ % CI , @ % -@ % ) who underwent biliary sphincterotomy , @ ( @ % ; @ % CI , @ % -@ % ) who underwent dual sphincterotomy , and @ ( @ % ; @ % CI , @ % -@ % ) who did not undergo sphincterotomy had successful treatment .", "sentence_id": 16}
+{"abstract_id": "24867013", "label": "conclusions", "text": "In patients with abdominal pain after cholecystectomy undergoing ERCP with manometry , sphincterotomy vs sham did not reduce disability due to pain .", "sentence_id": 17}
+{"abstract_id": "24867013", "label": "conclusions", "text": "These findings do not support ERCP and sphincterotomy for these patients .", "sentence_id": 18}
+{"abstract_id": "25249300", "label": "background", "text": "Glycosylated proteins partake in multiple cellular processes including inflammation .", "sentence_id": 0}
+{"abstract_id": "25249300", "label": "background", "text": "We hypothesized that GlycA , a novel biomarker of protein glycan N-acetyl groups , is related to incident cardiovascular disease ( CVD ) , and we compared it with high-sensitivity C-reactive protein ( hsCRP ) .", "sentence_id": 1}
+{"abstract_id": "25249300", "label": "results", "text": "In @ @ initially healthy women , baseline GlycA was quantified by nuclear magnetic resonance spectroscopy and hsCRP by an immunoturbidimetric assay .", "sentence_id": 2}
+{"abstract_id": "25249300", "label": "results", "text": "During median follow-up of @ years , @ incident CVD events occurred ( myocardial infarction , ischemic stroke , coronary revascularization , and CVD death ) .", "sentence_id": 3}
+{"abstract_id": "25249300", "label": "results", "text": "GlycA and hsCRP were moderately correlated ( Spearman r = @ , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "25249300", "label": "results", "text": "In Cox regression models that included age , ethnicity , smoking , blood pressure , medications , menopausal status , body mass index , and diabetes , hazard ratios for CVD across quartiles @ to @ of GlycA were @ , @ ( @ % CI , @ to @ ) , @ ( @ % CI , @ to @ ) , and @ ( @ % CI , @ to @ ) , similar to hsCRP , for which hazard ratios were @ , @ ( @ % CI , @ to @ ) , @ ( @ % CI , @ to @ ) , and @ ( @ % CI , @ to @ ) ( both Ptrend < @ ) .", "sentence_id": 5}
+{"abstract_id": "25249300", "label": "results", "text": "Associations were attenuated after additionally adjusting for lipids : the hazard ratio of quartile @ versus @ for GlycA was @ ( @ % CI , @ to @ ; Ptrend = @ ) and for hsCRP was @ ( @ % CI , @ to @ ; Ptrend < @ ) .", "sentence_id": 6}
+{"abstract_id": "25249300", "label": "results", "text": "Further adjustment for the other biomarker resulted in a hazard ratio of quartile @ versus @ for GlycA of @ ( @ % CI , @ to @ ; Ptrend = @ ) and for hsCRP of @ ( @ % CI , @ to @ ; Ptrend = @ ) .", "sentence_id": 7}
+{"abstract_id": "25249300", "label": "conclusions", "text": "In this prospective study of initially healthy women , baseline GlycA was associated with incident CVD , consistent with a possible role for protein glycans in inflammation and CVD .", "sentence_id": 8}
+{"abstract_id": "25339518", "label": "background", "text": "Rifaximin therapy reduced risk of hepatic encephalopathy ( HE ) recurrence and HE-related hospitalisations during a @-month , randomised , placebo-controlled trial ( RCT ) and a @-month open-label maintenance ( OLM ) study .", "sentence_id": 0}
+{"abstract_id": "25339518", "label": "background", "text": "However , the impact of crossover from placebo to rifaximin therapy is unclear .", "sentence_id": 1}
+{"abstract_id": "25339518", "label": "objective", "text": "To study the impact of crossing over from placebo to rifaximin treatment on breakthrough HE and hospitalisation rates using a within-subjects design .", "sentence_id": 2}
+{"abstract_id": "25339518", "label": "methods", "text": "Adults with cirrhosis and history of overt HE episodes , currently in HE remission , received placebo during the RCT and crossed over to rifaximin @mg twice daily during the OLM study .", "sentence_id": 3}
+{"abstract_id": "25339518", "label": "methods", "text": "Rate of breakthrough overt HE episodes , hospitalisations and incidence and rate of adverse events ( AEs ) were analysed during RCT and first @months of OLM .", "sentence_id": 4}
+{"abstract_id": "25339518", "label": "results", "text": "Of @ patients randomised to placebo in the RCT who crossed over to the OLM study , @ experienced an HE episode during the RCT compared with @ during the OLM study ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "25339518", "label": "results", "text": "Significantly lower rates of HE events were observed with rifaximin treatment compared with placebo treatment ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25339518", "label": "results", "text": "Rates of HE-related hospitalisation were numerically lower during rifaximin treatment compared with placebo treatment , although not significant .", "sentence_id": 7}
+{"abstract_id": "25339518", "label": "results", "text": "Rates of most common AEs , serious AEs and infection-related AEs were similar between the two treatments .", "sentence_id": 8}
+{"abstract_id": "25339518", "label": "conclusions", "text": "This analysis confirms the repeatability of results from the RCT on safety and efficacy of rifaximin @mg twice daily in reducing the risk of hepatic encephalopathy recurrence , and suggests these findings are translatable outside of a rigorous , controlled trial setting .", "sentence_id": 9}
+{"abstract_id": "26078250", "label": "objective", "text": "Long-chain polyunsaturated fatty acids ( LC-PUFA ) are regarded as essential for child cognition .", "sentence_id": 0}
+{"abstract_id": "26078250", "label": "objective", "text": "Genetic variation in fatty acid ( FA ) desaturase enzyme ( FADS ) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function .", "sentence_id": 1}
+{"abstract_id": "26078250", "label": "objective", "text": "This study aimed to identify the distribution of genetic variant ( genotype ) SNP rs@ and to assess plasma FA and developmental outcome by the genotype among under-@ year old Sasaknese Indonesian children .", "sentence_id": 2}
+{"abstract_id": "26078250", "label": "methods", "text": "Data was collected at baseline of a randomized trial ( NUPICO , clinicaltrials.gov NCT@ ) in East Lombok district , Indonesia .", "sentence_id": 3}
+{"abstract_id": "26078250", "label": "methods", "text": "Breastfed , @ - @ month old children were recruited and @ subjects were included in the study .", "sentence_id": 4}
+{"abstract_id": "26078250", "label": "methods", "text": "Child cognition was assessed as Bayley Mental Developmental Index ( MDI ) .", "sentence_id": 5}
+{"abstract_id": "26078250", "label": "results", "text": "From @ subjects whose blood samples can be collected , only two genotypes were found ( @ % GG homozygotes , @ % AG heterozygotes ) , and minor allele AG was significantly associated with higher level of arachidonic acid ( @:@ n-@ ) , n-@ LC-PUFA and FADS@ index .", "sentence_id": 6}
+{"abstract_id": "26078250", "label": "results", "text": "MDI score was associated with a FADS@ index ( DHA : EPA ratio ) but not genotype ( Adjusted R-square = @ ) .", "sentence_id": 7}
+{"abstract_id": "26078250", "label": "conclusions", "text": "FADS@ index was associated with cognitive function .", "sentence_id": 8}
+{"abstract_id": "26078250", "label": "conclusions", "text": "No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight .", "sentence_id": 9}
+{"abstract_id": "24944063", "label": "background", "text": "It is important to understand whether eating eggs , which are a major source of dietary choline , results in increased exposure to trimethylamine-N-oxide ( TMAO ) , which is purported to be a risk factor for developing heart disease .", "sentence_id": 0}
+{"abstract_id": "24944063", "label": "objective", "text": "We determined whether humans eating eggs generate TMAO and , if so , whether there is an associated increase in a marker for inflammation -LSB- ie , high-sensitivity C-reactive protein ( hsCRP ) -RSB- or increased oxidation of low-density lipoprotein ( LDL ) .", "sentence_id": 1}
+{"abstract_id": "24944063", "label": "methods", "text": "In a longitudinal , double-blind , randomized dietary intervention , @ volunteers were fed breakfast doses of @ , @ , @ , @ , or @ egg yolks .", "sentence_id": 2}
+{"abstract_id": "24944063", "label": "methods", "text": "Diets were otherwise controlled on the day before and day of each egg dose with a standardized low-choline menu .", "sentence_id": 3}
+{"abstract_id": "24944063", "label": "methods", "text": "Plasma TMAO at timed intervals ( immediately before and @ , @ , @ , @ , and @ h after each dose ) , @-h urine TMAO , predose and @-h postdose serum hsCRP , and plasma oxidized LDL were measured .", "sentence_id": 4}
+{"abstract_id": "24944063", "label": "methods", "text": "Volunteers received all @ doses with each dose separated by > @-wk washout periods .", "sentence_id": 5}
+{"abstract_id": "24944063", "label": "results", "text": "The consumption of eggs was associated with increased plasma and urine TMAO concentrations ( P < @ ) , with @ % of the total choline in eggs having been converted to TMAO .", "sentence_id": 6}
+{"abstract_id": "24944063", "label": "results", "text": "There was considerable variation between individuals in the TMAO response .", "sentence_id": 7}
+{"abstract_id": "24944063", "label": "results", "text": "There was no difference in hsCRP or oxidized LDL concentrations after egg doses .", "sentence_id": 8}
+{"abstract_id": "24944063", "label": "conclusions", "text": "The consumption of @ eggs results in an increased formation of TMAO .", "sentence_id": 9}
+{"abstract_id": "24944063", "label": "conclusions", "text": "Choline is an essential nutrient that is required for normal human liver and muscle functions and important for normal fetal development .", "sentence_id": 10}
+{"abstract_id": "24944063", "label": "conclusions", "text": "Additional study is needed to both confirm the association between TMAO and atherosclerosis and identify factors , microbiota and genetic , that influence the generation of TMAO before policy and medical recommendations are made that suggest reduced dietary choline intake .", "sentence_id": 11}
+{"abstract_id": "25038486", "label": "objective", "text": "Asunaprevir is a selective HCV NS@ protease inhibitor , active against genotypes @ , @ , @ , and @ in vitro .", "sentence_id": 0}
+{"abstract_id": "25038486", "label": "objective", "text": "We evaluated asunaprevir plus peginterferon alfa-@a / ribavirin ( PegIFN/RBV ) for genotype @ and @ chronic HCV .", "sentence_id": 1}
+{"abstract_id": "25038486", "label": "methods", "text": "In this phase @b , double-blind , placebo-controlled study , treatment-naive adults with genotype @ ( n = @ ) or @ ( n = @ ) were randomly assigned ( @:@ ) to asunaprevir @mg or placebo twice daily plus PegIFN/RBV .", "sentence_id": 2}
+{"abstract_id": "25038486", "label": "methods", "text": "Asunaprevir recipients , achieving protocol-defined response ( HCV-RNA below quantification limit at week @ and undetectable at week @ ) , were rerandomized at week @ to continue asunaprevir-based triple therapy or receive placebo plus PegIFN/RBV for weeks @-@ .", "sentence_id": 3}
+{"abstract_id": "25038486", "label": "methods", "text": "Patients without protocol-defined response ( PDR ) and placebo recipients continued PegIFN/RBV through week @ .", "sentence_id": 4}
+{"abstract_id": "25038486", "label": "methods", "text": "Co-primary end points were undetectable HCV-RNA at week @ and @ ( eRVR ) and @ weeks posttreatment ( SVR@ ) .", "sentence_id": 5}
+{"abstract_id": "25038486", "label": "results", "text": "Most patients were male ( @ % ) , white ( @ % ) , and had non-CC IL@B genotypes ( @ % ) .", "sentence_id": 6}
+{"abstract_id": "25038486", "label": "results", "text": "Among genotype @ patients , eRVR rates ( asunaprevir vs. placebo ) were @ % ( @ % CI @ , @ ) vs. @ % ( @ % CI @ , @ ) ; corresponding SVR@ rates were @ % ( @ % CI @ , @ ) vs. @ % ( @ % CI @ , @ ) .", "sentence_id": 7}
+{"abstract_id": "25038486", "label": "results", "text": "SVR@ among genotype @ patients was @ % ( asunaprevir ) vs. @ % ( placebo ) .", "sentence_id": 8}
+{"abstract_id": "25038486", "label": "results", "text": "Rates of rash and haematologic adverse events were similar between treatment groups .", "sentence_id": 9}
+{"abstract_id": "25038486", "label": "results", "text": "Five asunaprevir-treated patients had grade @ alanine aminotransferase elevations that resolved following discontinuation ( n = @ ) or with continued dosing ( n = @ ) .", "sentence_id": 10}
+{"abstract_id": "25038486", "label": "conclusions", "text": "Addition of asunaprevir to PegIFN/RBV in treatment-naive genotype @ - or @-infected patients improves response rates and is well tolerated , with aminotransferase elevations that were manageable with appropriate monitoring .", "sentence_id": 11}
+{"abstract_id": "25038486", "label": "conclusions", "text": "ClinicalTrials.gov ID : NCT@ .", "sentence_id": 12}
+{"abstract_id": "24439959", "label": "background", "text": "Depersonalization disorder ( DPD ) includes changes in subjective experiencing of self , encompassing emotional numbing .", "sentence_id": 0}
+{"abstract_id": "24439959", "label": "background", "text": "Functional magnetic resonance imaging ( fMRI ) has pointed to ventrolateral prefrontal cortex ( VLPFC ) inhibition of insula as a neurocognitive correlate of the disorder .", "sentence_id": 1}
+{"abstract_id": "24439959", "label": "objective", "text": "We hypothesized that inhibition to right VLPFC using repetitive transcranial magnetic stimulation ( rTMS ) would lead to increased arousal and reduced symptoms .", "sentence_id": 2}
+{"abstract_id": "24439959", "label": "methods", "text": "Patients with medication-resistant DSM-IV DPD ( N = @ ) and controls ( N = @ ) were randomized to receive one session of right-sided rTMS to VLPFC or temporo-parietal junction ( TPJ ) .", "sentence_id": 3}
+{"abstract_id": "24439959", "label": "methods", "text": "@ Hz rTMS was guided using neuronavigation and delivered for @ min .", "sentence_id": 4}
+{"abstract_id": "24439959", "label": "methods", "text": "Co-primary outcomes were : ( a ) maximum skin conductance capacity , and ( b ) reduction in depersonalization symptoms ( Cambridge Depersonalisation Scale ( CDS ) -LSB- state version -RSB- ) .", "sentence_id": 5}
+{"abstract_id": "24439959", "label": "methods", "text": "Secondary outcomes included spontaneous fluctuations ( SFs ) and event-related skin conductance responses .", "sentence_id": 6}
+{"abstract_id": "24439959", "label": "results", "text": "In patients with DPD , rTMS to VLPFC led to increased electrodermal capacity , namely maximum skin conductance deflections .", "sentence_id": 7}
+{"abstract_id": "24439959", "label": "results", "text": "Patients but not controls also showed increased SFs post rTMS .", "sentence_id": 8}
+{"abstract_id": "24439959", "label": "results", "text": "Patients who had either VLPFC or TPJ rTMS showed a similar significant reduction in symptoms .", "sentence_id": 9}
+{"abstract_id": "24439959", "label": "results", "text": "Event-related electrodermal activity did not change .", "sentence_id": 10}
+{"abstract_id": "24439959", "label": "conclusions", "text": "A single session of right-sided rTMS to VLPFC ( but not TPJ ) significantly increased physiological arousal capacity supporting our model regarding the relevance of increased VLPFC activity to emotional numbing in DPD .", "sentence_id": 11}
+{"abstract_id": "24439959", "label": "conclusions", "text": "rTMS to both sites led to reduced depersonalization scores but since this was independent of physiological arousal , this may be a non-specific effect .", "sentence_id": 12}
+{"abstract_id": "24439959", "label": "conclusions", "text": "TMS is a potential therapeutic option for DPD ; modulation of VLPFC , if replicated , is a plausible mechanism .", "sentence_id": 13}
+{"abstract_id": "24249853", "label": "objective", "text": "To determine whether a college of pharmacy curriculum creates a sense of self-efficacy among students with respect to providing medication therapy management ( MTM ) services .", "sentence_id": 0}
+{"abstract_id": "24249853", "label": "methods", "text": "An electronic survey instrument was sent to all pharmacy students to elicit information on their perceived confidence in providing MTM services , and the results were reviewed .", "sentence_id": 1}
+{"abstract_id": "24249853", "label": "results", "text": "Of the @,@ students targeted , @ ( @ % ) completed the survey instrument .", "sentence_id": 2}
+{"abstract_id": "24249853", "label": "results", "text": "Responses indicated that overall self-efficacy increased with each successive year of the curriculum that students completed .", "sentence_id": 3}
+{"abstract_id": "24249853", "label": "results", "text": "Fourth-year students completing an advanced pharmacy practice experience ( APPE ) in medication therapy management ( MTM ) had significantly higher self-efficacy than did other fourth-year students , whose self-efficacy was similar to that of third-year students .", "sentence_id": 4}
+{"abstract_id": "24249853", "label": "results", "text": "conclusion : In this study population , students ' self-efficacy increased with each successive year in pharmacy school , with those who completed an APPE in MTM exhibiting the highest level of self-efficacy .", "sentence_id": 5}
+{"abstract_id": "24249853", "label": "results", "text": "These students may be more likely to pursue MTM opportunities in future careers .", "sentence_id": 6}
+{"abstract_id": "24707612", "label": "objective", "text": "To show that patients with intertrochanteric fractures treated with a proximal femoral nail have a better postoperative course than those treated with a DHS plate ( dynamic hip screw ) .", "sentence_id": 0}
+{"abstract_id": "24707612", "label": "methods", "text": "Patients with a Boyd & Griffin type II intertrochanteric fracture were randomly divided into two groups : a group of patients treated with a PFN and another one treated with a DHS plate .", "sentence_id": 1}
+{"abstract_id": "24707612", "label": "methods", "text": "All patients were assessed at @ , @ , @ and @ weeks using the Harris scale and the visual analog scale pre - and postoperatively , as well as the operative time , incision size , intraoperative bleeding , onset of partial and/or total weight bearing , healing time , time to attain prior physical activity level , and radiographic result .", "sentence_id": 2}
+{"abstract_id": "24707612", "label": "results", "text": "@ patients met our criteria .", "sentence_id": 3}
+{"abstract_id": "24707612", "label": "results", "text": "The variables that had a significant reduction were : incision , operative time , postoperative pain according to the visual analog scale , onset of mobility , partial weight bearing and pain at @ weeks .", "sentence_id": 4}
+{"abstract_id": "24707612", "label": "conclusions", "text": "The proximal femoral nail has better short-term outcomes than the DHS plate ; however , in the medium term both implants have the same outcomes .", "sentence_id": 5}
+{"abstract_id": "25438965", "label": "objective", "text": "Completion rate for the three-dose series of the human papillomavirus ( HPV ) vaccine has generally been low .", "sentence_id": 0}
+{"abstract_id": "25438965", "label": "objective", "text": "This study evaluated the effectiveness of a reminder letter intervention on HPV vaccine three-dose series completion .", "sentence_id": 1}
+{"abstract_id": "25438965", "label": "methods", "text": "Female members of Kaiser Permanente Southern California Health Plan who received at least one dose , but not more than two doses , of the HPV vaccine by February @ , @ , and who were between ages @ and @ years at the time of first HPV vaccination were included .", "sentence_id": 2}
+{"abstract_id": "25438965", "label": "methods", "text": "Eighty percent of these females were randomized to receive the reminder letter , and @ % were randomized to receive standard of care ( control ) .", "sentence_id": 3}
+{"abstract_id": "25438965", "label": "methods", "text": "The reminder letters were mailed quarterly to those who had not completed the series .", "sentence_id": 4}
+{"abstract_id": "25438965", "label": "methods", "text": "The proportion of series completion at the end of the @-month evaluation period was compared using chi-square test .", "sentence_id": 5}
+{"abstract_id": "25438965", "label": "results", "text": "A total of @,@ females were included in the intervention group and @,@ in the control group .", "sentence_id": 6}
+{"abstract_id": "25438965", "label": "results", "text": "HPV vaccine series completion was @ % in the intervention group and @ % in the control groups ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25438965", "label": "results", "text": "The effect of the intervention appeared to be stronger in girls aged @-@years compared with young women aged @-@years at the first dose and in blacks compared with whites .", "sentence_id": 8}
+{"abstract_id": "25438965", "label": "conclusions", "text": "Reminder letters scheduled quarterly were effective to enhance HPV vaccine series completion among those who initiated the vaccine .", "sentence_id": 9}
+{"abstract_id": "25438965", "label": "conclusions", "text": "However , a large gap in series completion remained despite the intervention .", "sentence_id": 10}
+{"abstract_id": "25438965", "label": "conclusions", "text": "Future studies should address other barriers to series completion , including those at the providers and the health care system level .", "sentence_id": 11}
+{"abstract_id": "24942481", "label": "objective", "text": "To evaluate the cost effectiveness of a behavioural therapy intervention shown to be clinically effective in comparison with usual care for stroke patients with aphasia .", "sentence_id": 0}
+{"abstract_id": "24942481", "label": "methods", "text": "Randomised controlled trial with comparison of costs and calculation of incremental cost effectiveness ratio .", "sentence_id": 1}
+{"abstract_id": "24942481", "label": "methods", "text": "Community .", "sentence_id": 2}
+{"abstract_id": "24942481", "label": "methods", "text": "Participants identified as having low mood on either the Visual Analog Mood Scale sad item ( @ ) or Stroke Aphasic Depression Questionnaire Hospital version @ ( SADQH@ ) ( @ ) were recruited .", "sentence_id": 3}
+{"abstract_id": "24942481", "label": "methods", "text": "Participants were randomly allocated to behavioural therapy or usual care using internet-based randomisation generated in advance of the study by a clinical trials unit .", "sentence_id": 4}
+{"abstract_id": "24942481", "label": "methods", "text": "Outcomes were assessed at six months after randomisation , blind to group allocation .", "sentence_id": 5}
+{"abstract_id": "24942481", "label": "methods", "text": "The costs were assessed from a service use questionnaire .", "sentence_id": 6}
+{"abstract_id": "24942481", "label": "methods", "text": "Effectiveness was defined as the change in SADQH@ scores and a cost-effectiveness analysis was performed comparing the behavioural group with the usual care control group .", "sentence_id": 7}
+{"abstract_id": "24942481", "label": "methods", "text": "The cost analysis was undertaken from the perspective of the UK NHS and Social Services .", "sentence_id": 8}
+{"abstract_id": "24942481", "label": "results", "text": "The greatest difference was in home help costs where there was a saving of @ in the intervention group compared to an increase of @ in the control group .", "sentence_id": 9}
+{"abstract_id": "24942481", "label": "results", "text": "At six months the SADQH@ score for the intervention group was @ compared to the control group value of @ .", "sentence_id": 10}
+{"abstract_id": "24942481", "label": "results", "text": "This resulted in a mean increase of @ in the control group , compared to a mean significant different decrease of @ in the intervention group ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24942481", "label": "results", "text": "The Incremental Cost-Effectiveness Ratio indicated that the cost per point reduction on the SADQH@ was @ .", "sentence_id": 12}
+{"abstract_id": "24942481", "label": "conclusions", "text": "Overall the behavioural therapy was found to improve mood and resulted in some encouraging savings in resource utilisation over the six months follow-up .", "sentence_id": 13}
+{"abstract_id": "25639198", "label": "objective", "text": "This study aimed to compare application of the Mller maneuver ( MM ) and application of drug-induced sleep endoscopy ( DISE ) prior to surgery , in addition to MM , to further ascertain the location of an obstruction in the upper airway and whether the location would change the surgical treatment plan in patients with retropalatal obstruction .", "sentence_id": 0}
+{"abstract_id": "25639198", "label": "methods", "text": "Prospective , clinical trial at a tertiary referral hospital .", "sentence_id": 1}
+{"abstract_id": "25639198", "label": "methods", "text": "This study included @ obstructive sleep apnea patients who were recommended for surgical treatment .", "sentence_id": 2}
+{"abstract_id": "25639198", "label": "methods", "text": "Patients were randomly divided into two groups : The first group ( DISE plus MM ) underwent a DISE ( @ patients ) , in addition to the planned procedure according to MM .", "sentence_id": 3}
+{"abstract_id": "25639198", "label": "methods", "text": "Meanwhile , the second group ( MM only ) underwent surgery based only on their MM evaluation ( @ patients ) .", "sentence_id": 4}
+{"abstract_id": "25639198", "label": "methods", "text": "Patients with retrolingual-localized obstructions were excluded , whereas patients withthird-degree obstructions at the retropalatal level , according to DISE and/or MM , were included in the study .", "sentence_id": 5}
+{"abstract_id": "25639198", "label": "results", "text": "There was a significant improvement between pre - and postoperative polysomnography findings in both groups .", "sentence_id": 6}
+{"abstract_id": "25639198", "label": "results", "text": "However , the postoperative improvements between the groups were not statistically different .", "sentence_id": 7}
+{"abstract_id": "25639198", "label": "results", "text": "Because there was a significant change in the planned surgical procedures in the first group , there were significantly more combined surgeries followed by the DISE procedure .", "sentence_id": 8}
+{"abstract_id": "25639198", "label": "conclusions", "text": "Although the DISE resulted in more changes in the surgical treatment plan and higher rate of combined treatment compared to MM , we determined that this difference did not result in a significant difference in treatment success .", "sentence_id": 9}
+{"abstract_id": "24618303", "label": "objective", "text": "This study investigated improvements in quality of life associated with eight weeks of montelukast and/or intranasal steroid treatment for moderate to severe allergic rhinitis .", "sentence_id": 0}
+{"abstract_id": "24618303", "label": "methods", "text": "A single-centre , prospective , randomised , double-blind , placebo-controlled study was carried out .", "sentence_id": 1}
+{"abstract_id": "24618303", "label": "methods", "text": "Assessments were made using the Rhinoconjunctivitis Quality of Life Questionnaire and symptom scales .", "sentence_id": 2}
+{"abstract_id": "24618303", "label": "results", "text": "A total of @ patients ( aged @-@ years ) were randomly assigned to one of two groups .", "sentence_id": 3}
+{"abstract_id": "24618303", "label": "results", "text": "In the montelukast group , patients were treated with montelukast tablets and fluticasone propionate nasal spray ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24618303", "label": "results", "text": "In the placebo group , treatment comprised a placebo and fluticasone propionate .", "sentence_id": 5}
+{"abstract_id": "24618303", "label": "results", "text": "The results showed significant improvements in symptom scores and quality of life scores for both groups after one month and two months of treatment , compared with baseline values ; these improvements were significantly greater for the montelukast group compared with the placebo group .", "sentence_id": 6}
+{"abstract_id": "24618303", "label": "results", "text": "The mean number of loratadine tablets taken by each patient during the study period was only @ for the montelukast group compared with @ for the placebo group .", "sentence_id": 7}
+{"abstract_id": "24618303", "label": "conclusions", "text": "The combination of montelukast tablets and fluticasone propionate nasal spray improved symptom control and overall quality of life for moderate to severe allergic rhinitis patients .", "sentence_id": 8}
+{"abstract_id": "25609935", "label": "background", "text": "Physical rehabilitation is commonly used in patients with Parkinson 's disease ( PD ) to improve their health and alleviate the symptoms .", "sentence_id": 0}
+{"abstract_id": "25609935", "label": "objective", "text": "We compared the effects of three programs , strength training ( ST ) , aerobic training ( AT ) , and physiotherapy , on motor symptoms , functional capacity , and electroencephalographic ( EEG ) activity in PD patients .", "sentence_id": 1}
+{"abstract_id": "25609935", "label": "methods", "text": "Twenty-two patients were recruited and randomized into three groups : AT ( @ % of maximum heart rate ) , ST ( @ % of one repetition maximum ) , and physiotherapy ( in groups ) .", "sentence_id": 2}
+{"abstract_id": "25609935", "label": "methods", "text": "Subjects participated in their respective interventions twice a week for @ weeks .", "sentence_id": 3}
+{"abstract_id": "25609935", "label": "methods", "text": "The assessments included measures of disease symptoms ( Unified Parkinson 's Disease Rating Scale -LSB- UPDRS -RSB- ) , functional capacity ( Senior Fitness Test ) , and EEG before and after @ weeks of intervention .", "sentence_id": 4}
+{"abstract_id": "25609935", "label": "results", "text": "The PD motor symptoms ( UPDRS-III ) in the group of patients who performed ST and AT improved by @ % ( effect size -LSB- ES -RSB- = @ , confidence interval -LSB- CI -RSB- = -@ , @ ) and @ % ( ES = @ , CI = -@ , @ ) , respectively , in contrast to the physiotherapy group , which showed a @ % improvement ( ES = @ , CI = -@ , @ ) .", "sentence_id": 5}
+{"abstract_id": "25609935", "label": "results", "text": "Furthermore , the functional capacity of all three groups improved after the intervention .", "sentence_id": 6}
+{"abstract_id": "25609935", "label": "results", "text": "The mean frequency of the EEG analysis mainly showed the effect of the interventions on the groups ( F = @ , P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25609935", "label": "conclusions", "text": "ST and AT in patients with PD are associated with improved outcomes in disease symptoms and functional capacity .", "sentence_id": 8}
+{"abstract_id": "25051390", "label": "objective", "text": "The objective of this study is to determine the effects of a caffeine-containing energy drink on female volleyball players ' performance .", "sentence_id": 0}
+{"abstract_id": "25051390", "label": "methods", "text": "Thirteen elite female volleyball players ingested @ mgkg of caffeine with an energy drink or the same drink without caffeine ( placebo drink ) in a double-blind and randomized study .", "sentence_id": 1}
+{"abstract_id": "25051390", "label": "methods", "text": "Then , participants performed the following : standing spike , jumping spike , spike jump , blocking jump , squat jump , countermovement jump , manual dynamometry , and the agility t-test .", "sentence_id": 2}
+{"abstract_id": "25051390", "label": "methods", "text": "A simulated volleyball game was played , videotaped , and notated afterward .", "sentence_id": 3}
+{"abstract_id": "25051390", "label": "results", "text": "In comparison to the placebo drink , the ingestion of the caffeinated energy drink increased the ball velocity in the standing spike ( @ @ vs @ @ ms , P = @ ) and in the jumping spike ( @ @ vs @ @ ms , P = @ ) and the jump height in the squat jump ( @ @ vs @ @ cm , P = @ ) , countermovement jump ( @ @ vs @ @ cm , P = @ ) , spike jump ( @ @ vs @ @ cm , P = @ ) , and block jump ( @ @ vs @ @ cm , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "25051390", "label": "results", "text": "Furthermore , the caffeinated energy drink decreased the time needed to complete the agility t-test ( @ @ vs @ @ s , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "25051390", "label": "results", "text": "During the game , the volleyball actions categorized as successful were more frequent with the caffeinated energy drink ( @ % @ % vs @ % @ % , P < @ ) , whereas imprecise actions decreased ( @ % @ % vs @ % @ % , P < @ ) when compared with the placebo drink .", "sentence_id": 6}
+{"abstract_id": "25051390", "label": "conclusions", "text": "Commercially available energy drinks can significantly improve physical performance in female volleyball players .", "sentence_id": 7}
+{"abstract_id": "25051390", "label": "conclusions", "text": "Increased physical performance led to improved accuracy during an actual volleyball match .", "sentence_id": 8}
+{"abstract_id": "24423298", "label": "background", "text": "Data on the metabolic effects of GH derived from studies using GH suppression by pharmacological agents may not reflect selective actions .", "sentence_id": 0}
+{"abstract_id": "24423298", "label": "objective", "text": "The purpose of this study was to evaluate the effects of GH antagonism on glucose and lipid metabolism using pegvisomant , a selective GH receptor antagonist in patients with type @ diabetes ( T@D ) .", "sentence_id": 1}
+{"abstract_id": "24423298", "label": "methods", "text": "In a randomized , placebo-controlled , crossover study , @ young adults with T@D were evaluated at baseline and after @ weeks of treatment with either @ mg of pegvisomant or placebo .", "sentence_id": 2}
+{"abstract_id": "24423298", "label": "methods", "text": "The assessments included an overnight euglycemic steady state followed by a hyperinsulinemic euglycemic clamp and used glucose and glycerol cold stable isotopes .", "sentence_id": 3}
+{"abstract_id": "24423298", "label": "methods", "text": "Hepatic and peripheral insulin sensitivity ( IS ) , lipid turnover , and intramyocellular lipid ( IMCL ) were measured .", "sentence_id": 4}
+{"abstract_id": "24423298", "label": "results", "text": "Compared with placebo , pegvisomant treatment resulted in lower IGF-I levels ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24423298", "label": "results", "text": "During the overnight steady state , insulin requirements for euglycemia ( P = @ ) , insulin levels ( P = @ ) , and glucose production rates ( Ra ) ( P = @ ) were reduced .", "sentence_id": 6}
+{"abstract_id": "24423298", "label": "results", "text": "During the clamp study , glucose infusion rates ( P = @ ) increased and glucose Ra ( P = @ ) decreased whereas glucose disposal rates were unchanged .", "sentence_id": 7}
+{"abstract_id": "24423298", "label": "results", "text": "Free fatty acid levels were similar during the steady state but were lower during the clamp ( P = @ ) after pegvisomant .", "sentence_id": 8}
+{"abstract_id": "24423298", "label": "results", "text": "Soleus muscle IMCL decreased after treatment ( P = @ ) ; however , no change in tibialis anterior muscle was observed .", "sentence_id": 9}
+{"abstract_id": "24423298", "label": "conclusions", "text": "The study demonstrates that GH antagonism in T@D results in improved hepatic insulin sensitivity .", "sentence_id": 10}
+{"abstract_id": "24423298", "label": "conclusions", "text": "Lack of consistent changes in free fatty acid levels may suggest a direct effect of GH on IS .", "sentence_id": 11}
+{"abstract_id": "24423298", "label": "conclusions", "text": "Unchanged peripheral IS despite reductions in IMCL indicate that GH-induced alterations in IMCL may not be causally linked to glucose metabolism .", "sentence_id": 12}
+{"abstract_id": "25322473", "label": "objective", "text": "Patient decision aids have been used in many clinical situations to improve the patient centeredness of care .", "sentence_id": 0}
+{"abstract_id": "25322473", "label": "objective", "text": "A patient decision aid for patients with posttraumatic stress disorder ( PTSD ) has not been developed or tested .", "sentence_id": 1}
+{"abstract_id": "25322473", "label": "objective", "text": "The authors evaluated the effects of a patient decision aid on the patient centeredness of PTSD treatment .", "sentence_id": 2}
+{"abstract_id": "25322473", "label": "methods", "text": "The study was a randomized trial of a patient decision aid for PTSD versus treatment as usual ( control group ) .", "sentence_id": 3}
+{"abstract_id": "25322473", "label": "methods", "text": "The participants were @ male and female veterans who presented to a single U.S. Department of Veterans Affairs hospital with a new diagnosis of PTSD .", "sentence_id": 4}
+{"abstract_id": "25322473", "label": "methods", "text": "Patient centeredness was assessed by knowledge of PTSD and its treatment , level of decisional uncertainty , and ability to state a preferred treatment option .", "sentence_id": 5}
+{"abstract_id": "25322473", "label": "methods", "text": "Secondary outcomes included treatments received and PTSD symptoms in the six months after study entry .", "sentence_id": 6}
+{"abstract_id": "25322473", "label": "results", "text": "Compared with the control group ( N = @ ) , participants who reviewed the patient decision aid ( N = @ ) had higher scores for PTSD knowledge ( p = @ ) and less conflict about their choice of treatment ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25322473", "label": "results", "text": "In addition , participants who reviewed the patient decision aid were more likely to select and receive an evidence-based treatment for PTSD ( p = @ ) and had superior PTSD outcomes ( p = @ ) compared with the control group .", "sentence_id": 8}
+{"abstract_id": "25322473", "label": "conclusions", "text": "Use of a patient decision aid was associated with improvements in patient-centered PTSD treatment .", "sentence_id": 9}
+{"abstract_id": "25322473", "label": "conclusions", "text": "The patient decision aid was also associated with greater use of evidence-based treatments and improvement of PTSD symptoms .", "sentence_id": 10}
+{"abstract_id": "25322473", "label": "conclusions", "text": "This study suggests that clinics should consider using a patient decision aid for patients with PTSD .", "sentence_id": 11}
+{"abstract_id": "25682480", "label": "background", "text": "Cocaine addiction continues to be a significant healthcare issue , yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States .", "sentence_id": 0}
+{"abstract_id": "25682480", "label": "methods", "text": "This @-week , prospective , double-blind , randomized , placebo-controlled study examined the effectiveness of quetiapine ( Seroquel XR ) versus matched placebo for the treatment of DSM-IV cocaine dependence in non-psychotic individuals .", "sentence_id": 1}
+{"abstract_id": "25682480", "label": "methods", "text": "Subjects randomized to quetiapine ( N = @ ) were titrated up to a target dose of @mg/day of quetiapine , while those in the placebo arm ( N = @ ) were given a matched placebo .", "sentence_id": 2}
+{"abstract_id": "25682480", "label": "methods", "text": "All subjects had weekly clinic visits and a cognitive-behavioral therapy group session .", "sentence_id": 3}
+{"abstract_id": "25682480", "label": "methods", "text": "Outcome measures included self-report of cocaine use and money spent on cocaine as well as urine drug screens ( UDS ) .", "sentence_id": 4}
+{"abstract_id": "25682480", "label": "results", "text": "The drop-out rate was substantial at @ % .", "sentence_id": 5}
+{"abstract_id": "25682480", "label": "results", "text": "Logistic regression analysis did not find significant differences between groups in predicting end-of trial abstinence , defined as three consecutive weekly negative UDS ( @ % in the quetiapine group versus @ % in the placebo group ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25682480", "label": "results", "text": "Based upon a repeated measures analysis of variance , subjects in this study , as a whole , demonstrated reductions in their self-reported use of cocaine , self-reported money spent on cocaine , and number of days per week using cocaine .", "sentence_id": 7}
+{"abstract_id": "25682480", "label": "results", "text": "However , the quetiapine group did not differ significantly from the placebo group .", "sentence_id": 8}
+{"abstract_id": "25682480", "label": "conclusions", "text": "This study did not find group differences between the quetiapine and placebo arms , suggesting that quetiapine is not an efficacious treatment for DSM-IV cocaine dependence .", "sentence_id": 9}
+{"abstract_id": "25323260", "label": "background", "text": "Intraventricular fluid dynamics can be assessed clinically using imaging .", "sentence_id": 0}
+{"abstract_id": "25323260", "label": "background", "text": "The contribution of vortex structures to left ventricular ( LV ) diastolic function has never been quantified in vivo .", "sentence_id": 1}
+{"abstract_id": "25323260", "label": "objective", "text": "This study sought to understand the impact of intraventricular flow patterns on filling and to assess whether impaired fluid dynamics may be a source of diastolic dysfunction .", "sentence_id": 2}
+{"abstract_id": "25323260", "label": "methods", "text": "Two-dimensional flow velocity fields from color Doppler echocardiographic sequences were obtained in @ patients with nonischemic dilated cardiomyopathy ( NIDCM ) , @ patients with hypertrophic cardiomyopathy ( HCM ) , and @ control healthy volunteers .", "sentence_id": 3}
+{"abstract_id": "25323260", "label": "methods", "text": "Using a flow decomposition method , we isolated the rotational velocity generated by the vortex ring from the surrounding flow in the left ventricle .", "sentence_id": 4}
+{"abstract_id": "25323260", "label": "results", "text": "The vortex was responsible for entering @ @ % of filling volume in the control group and @ @ % in the NIDCM group ( p = @ ) , but only @ @ % in the HCM group ( p < @ vs. controls ) .", "sentence_id": 5}
+{"abstract_id": "25323260", "label": "results", "text": "Favorable vortical effects on intraventricular pressure gradients were observed in the control and NIDCM groups but not in HCM patients .", "sentence_id": 6}
+{"abstract_id": "25323260", "label": "results", "text": "Differences in chamber sphericity explained variations in the vortex contribution to filling between groups ( p < @ ) .", "sentence_id": 7}
+{"abstract_id": "25323260", "label": "conclusions", "text": "The diastolic vortex is responsible for entering a significant fraction of LV filling volume at no energetic or pressure cost .", "sentence_id": 8}
+{"abstract_id": "25323260", "label": "conclusions", "text": "Thus , intraventricular fluid mechanics are an important determinant of global chamber LV operative stiffness .", "sentence_id": 9}
+{"abstract_id": "25323260", "label": "conclusions", "text": "Reduced stiffness in NIDCM is partially related to enhanced vorticity .", "sentence_id": 10}
+{"abstract_id": "25323260", "label": "conclusions", "text": "Conversely , impaired vortex generation is an unreported mechanism of diastolic dysfunction in HCM and probably other causes of concentric remodeling .", "sentence_id": 11}
+{"abstract_id": "24628705", "label": "background", "text": "There is growing evidence that Cognitive Simulation Therapy ( CST ) benefits cognition and quality of life of people with dementia , but little is known about the indirect effects of this intervention on family caregivers .", "sentence_id": 0}
+{"abstract_id": "24628705", "label": "background", "text": "This study sought to investigate the effect of CST on family caregivers general health status of people with dementia living in the community attending the CST intervention .", "sentence_id": 1}
+{"abstract_id": "24628705", "label": "methods", "text": "Eighty-five family caregivers of people with dementia took part in the study .", "sentence_id": 2}
+{"abstract_id": "24628705", "label": "methods", "text": "All the people with dementia received the standard twice weekly seven weeks of the CST intervention plus either @ weeks of a maintenance CST ( MCST ) intervention or @ weeks of treatment as usual .", "sentence_id": 3}
+{"abstract_id": "24628705", "label": "methods", "text": "Family caregivers were assessed before and after their relatives the CST programme , and after @ and @ months of the MCST programme .", "sentence_id": 4}
+{"abstract_id": "24628705", "label": "methods", "text": "A pre and post CST groups comparison was undertaken to evaluate the open trial first phase and an ANCOVA model used to analyse the maintenance phase with its controlled comparison .", "sentence_id": 5}
+{"abstract_id": "24628705", "label": "results", "text": "We found no evidence for a benefit on the family caregiver outcome measures of the intervention before and after CST groups by using a t-test analysis or any significant differences between intervention and control groups for any of the variables considered at any time point ( @ and @ month follow up ) .", "sentence_id": 6}
+{"abstract_id": "24628705", "label": "conclusions", "text": "CST seems to have a relatively specific benefit fpr people with dementia that may not carry over to family carers .", "sentence_id": 7}
+{"abstract_id": "24628705", "label": "conclusions", "text": "Future studies need to further explore and compare the effects that CST might bring to family caregivers of people with dementia attending the intervention .", "sentence_id": 8}
+{"abstract_id": "25524950", "label": "objective", "text": "To compare pharmacokinetics ( PK ) and pharmacodynamics ( PD ) of insulin glargine in type @ diabetes mellitus ( T@DM ) after evening versus morning administration .", "sentence_id": 0}
+{"abstract_id": "25524950", "label": "methods", "text": "Ten T@DM insulin-treated persons were studied during @-h euglycemic glucose clamp , after glargine injection ( @ units/kg s.c. ) , either in the evening ( @ h ) or the morning ( @ h ) .", "sentence_id": 1}
+{"abstract_id": "25524950", "label": "results", "text": "The @-h glucose infusion rate area under the curve ( AUC@-@h ) was similar in the evening and morning studies ( @,@ @ and @ @ mg/kg @ h , P = @ ) , but the first @ h ( AUC@-@h ) was lower with evening versus morning glargine ( @ @ vs. @ @ mg/kg @ h , P = @ ) , whereas the opposite occurred for the second @ h ( AUC@-@h @ @ vs. @ @ mg/kg @ h , P = @ ) .", "sentence_id": 2}
+{"abstract_id": "25524950", "label": "results", "text": "The glucose infusion rate differences were totally accounted for by different rates of endogenous glucose production , not utilization .", "sentence_id": 3}
+{"abstract_id": "25524950", "label": "results", "text": "Plasma insulin and C-peptide levels did not differ in evening versus morning studies .", "sentence_id": 4}
+{"abstract_id": "25524950", "label": "results", "text": "Plasma glucagon levels ( AUC@-@h @,@ @ vs. @,@ @ ng/L/h , P = @ ) and lipolysis ( free fatty acid AUC@-@h @ @ vs. @ @ mmol/L/h , P = @ ; - OH-butyrate AUC@-@h @ @ vs. @ @ mmol/L/h , P = @ ; glycerol , P < @ ) were overall more suppressed after evening versus morning glargine administration .", "sentence_id": 5}
+{"abstract_id": "25524950", "label": "conclusions", "text": "The PD of insulin glargine differs depending on time of administration .", "sentence_id": 6}
+{"abstract_id": "25524950", "label": "conclusions", "text": "With morning administration insulin activity is greater in the first @-@ h , while with evening administration the activity is greater in the @-@ h period following dosing .", "sentence_id": 7}
+{"abstract_id": "25524950", "label": "conclusions", "text": "However , glargine PK and plasma C-peptide levels were similar , as well as glargine PD when analyzed by @-h clock time independent of the time of administration .", "sentence_id": 8}
+{"abstract_id": "25524950", "label": "conclusions", "text": "Thus , the results reflect the impact of circadian changes in insulin sensitivity in T@DM ( lower in the night-early morning vs. afternoon hours ) rather than glargine per se .", "sentence_id": 9}
+{"abstract_id": "25419615", "label": "objective", "text": "Varicella-zoster virus ( VZV ) infections increasingly are reported in patients with multiple sclerosis ( MS ) and constitute an area of significant concern , especially with the advent of more disease-modifying treatments in MS that affect T-cell-mediated immunity .", "sentence_id": 0}
+{"abstract_id": "25419615", "label": "objective", "text": "To assess the incidence , risk factors , and clinical characteristics of VZV infections in fingolimod-treated patients and provide recommendations for prevention and management .", "sentence_id": 1}
+{"abstract_id": "25419615", "label": "methods", "text": "Rates of VZV infections in fingolimod clinical trials are based on pooled data from the completed controlled phases @ and @ studies ( @ participants ) and ongoing uncontrolled extension phases ( @ participants ) .", "sentence_id": 2}
+{"abstract_id": "25419615", "label": "methods", "text": "Male and female patients aged @ through @ years ( @-@ years for the phase @ studies ) and diagnosed as having relapsing-remitting MS were eligible to participate in these studies .", "sentence_id": 3}
+{"abstract_id": "25419615", "label": "methods", "text": "In the postmarketing setting , reporting rates since @ were evaluated .", "sentence_id": 4}
+{"abstract_id": "25419615", "label": "methods", "text": "In clinical trials , patients received fingolimod at a dosage of @ or @ mg/d , interferon beta-@a , or placebo .", "sentence_id": 5}
+{"abstract_id": "25419615", "label": "methods", "text": "In the postmarketing setting , all patients received fingolimod , @ mg/d ( total exposure of @,@ patient-years at the time of analysis ) .", "sentence_id": 6}
+{"abstract_id": "25419615", "label": "methods", "text": "Calculation of the incidence rate of VZV infection per @ patient-years was based on the reporting of adverse events in the trials and the postmarketing setting .", "sentence_id": 7}
+{"abstract_id": "25419615", "label": "results", "text": "Overall , in clinical trials , VZV rates of infection were low but higher with fingolimod compared with placebo ( @ vs @ per @ patient-years ) .", "sentence_id": 8}
+{"abstract_id": "25419615", "label": "results", "text": "A similar rate was confirmed in the ongoing extension studies .", "sentence_id": 9}
+{"abstract_id": "25419615", "label": "results", "text": "Rates reported in the postmarketing settings were comparable ( @ per @ patient-years ) and remained stable over time .", "sentence_id": 10}
+{"abstract_id": "25419615", "label": "results", "text": "Disproportionality in reporting herpes zoster infection was higher for patients receiving fingolimod compared with those receiving other disease-modifying treatments ( empirical Bayes geometric mean , @ -LSB- @ % CI , @-@ @ -RSB- ) ; the proportion of serious herpes zoster infections was not higher than the proportion for other treatments ( empirical Bayes geometric mean , @ -LSB- @ % CI , @-@ @ -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "25419615", "label": "results", "text": "Corticosteroid treatment for relapses might be a risk factor for VZV reactivation .", "sentence_id": 12}
+{"abstract_id": "25419615", "label": "conclusions", "text": "Rates of VZV infections in clinical trials were low with fingolimod , @ mg/d , but higher than in placebo recipients .", "sentence_id": 13}
+{"abstract_id": "25419615", "label": "conclusions", "text": "Rates reported in the postmarketing setting are comparable .", "sentence_id": 14}
+{"abstract_id": "25419615", "label": "conclusions", "text": "We found no sign of risk accumulation with longer exposure .", "sentence_id": 15}
+{"abstract_id": "25419615", "label": "conclusions", "text": "Serious or complicated cases of herpes zoster were uncommon .", "sentence_id": 16}
+{"abstract_id": "25419615", "label": "conclusions", "text": "We recommend establishing the patient 's VZV immune status before initiating fingolimod therapy and immunization for patients susceptible to primary VZV infection .", "sentence_id": 17}
+{"abstract_id": "25419615", "label": "conclusions", "text": "Routine antiviral prophylaxis is not needed , but using concomitant pulsed corticosteroid therapy beyond @ to @ days requires an individual risk-benefit assessment .", "sentence_id": 18}
+{"abstract_id": "25419615", "label": "conclusions", "text": "Vigilance to identify early VZV symptoms is important to allow timely antiviral treatment .", "sentence_id": 19}
+{"abstract_id": "25286782", "label": "objective", "text": "Administration of many drugs including magnesium sulfate ( MS ) has considerable influences on pregnancy outcomes .", "sentence_id": 0}
+{"abstract_id": "25286782", "label": "objective", "text": "The present study investigates the effects of MS administration on reaching the active phase of labor in women with premature rupture of membrane ( PROM ) and subsequent fetal complications .", "sentence_id": 1}
+{"abstract_id": "25286782", "label": "methods", "text": "A double blind , randomized , placebo-controlled trial was performed among primipara women referred to the PROM center in Tehran , Iran between March @ and August @ .", "sentence_id": 2}
+{"abstract_id": "25286782", "label": "methods", "text": "Patients were equally allocated into two groups ; the intervention group who received MS ( n = @ ) and the control ( placebo ) group ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25286782", "label": "methods", "text": "Both groups received a corticosteroid , @g oral azithromycin ( oral ) and @ g ampicillin ( IV ) every @ hours for @ hours , followed by amoxicillin ( @ mg orally @ times daily ) for an additional @ days .", "sentence_id": 4}
+{"abstract_id": "25286782", "label": "methods", "text": "None of the research staff were aware of the treatment allocation of patients in order for blinding purposes .", "sentence_id": 5}
+{"abstract_id": "25286782", "label": "results", "text": "Administration of MS in intervention group increases this period @ times compared to the control group .", "sentence_id": 6}
+{"abstract_id": "25286782", "label": "results", "text": "In women whose gestational age was < @ weeks , MS administration increased the active phase of labor up to @ % .", "sentence_id": 7}
+{"abstract_id": "25286782", "label": "results", "text": "Administration of magnesium sulfate reduced the risk of respiratory distress syndrome significantly ( p = @ @ ) , without producing any adverse pregnancy outcomes .", "sentence_id": 8}
+{"abstract_id": "25286782", "label": "conclusions", "text": "Magnesium sulfate increases delay in reaching the active phase of labor in mothers with PROM , without producing adverse birth outcomes .", "sentence_id": 9}
+{"abstract_id": "25286782", "label": "conclusions", "text": "( Registration ID in IRCT ; IRCT@N@ ) .", "sentence_id": 10}
+{"abstract_id": "25096690", "label": "objective", "text": "The United States has invested substantially in screening and brief intervention for illicit drug use and prescription drug misuse , based in part on evidence of efficacy for unhealthy alcohol use .", "sentence_id": 0}
+{"abstract_id": "25096690", "label": "objective", "text": "However , it is not a recommended universal preventive service in primary care because of lack of evidence of efficacy .", "sentence_id": 1}
+{"abstract_id": "25096690", "label": "objective", "text": "To test the efficacy of @ brief counseling interventions for unhealthy drug use ( any illicit drug use or prescription drug misuse ) - a brief negotiated interview ( BNI ) and an adaptation of motivational interviewing ( MOTIV ) - compared with no brief intervention .", "sentence_id": 2}
+{"abstract_id": "25096690", "label": "methods", "text": "This @-group randomized trial took place at an urban hospital-based primary care internal medicine practice ; @ adult primary care patients with drug use ( Alcohol , Smoking , and Substance Involvement Screening Test -LSB- ASSIST -RSB- substance-specific scores of @ ) were identified by screening between June @ and January @ in Boston , Massachusetts .", "sentence_id": 3}
+{"abstract_id": "25096690", "label": "methods", "text": "Two interventions were tested : the BNI is a @ - to @-minute structured interview conducted by health educators ; the MOTIV is a @ - to @-minute intervention based on motivational interviewing with a @ - to @-minute booster conducted by master 's - level counselors .", "sentence_id": 4}
+{"abstract_id": "25096690", "label": "methods", "text": "All study participants received a written list of substance use disorder treatment and mutual help resources .", "sentence_id": 5}
+{"abstract_id": "25096690", "label": "methods", "text": "Primary outcome was number of days of use in the past @ days of the self-identified main drug as determined by a validated calendar method at @ months .", "sentence_id": 6}
+{"abstract_id": "25096690", "label": "methods", "text": "Secondary outcomes included other self-reported measures of drug use , drug use according to hair testing , ASSIST scores ( severity ) , drug use consequences , unsafe sex , mutual help meeting attendance , and health care utilization .", "sentence_id": 7}
+{"abstract_id": "25096690", "label": "results", "text": "At baseline , @ % of participants reported their main drug was marijuana , @ % cocaine , and @ % opioids .", "sentence_id": 8}
+{"abstract_id": "25096690", "label": "results", "text": "At @ months , @ % completed follow-up .", "sentence_id": 9}
+{"abstract_id": "25096690", "label": "results", "text": "Mean adjusted number of days using the main drug at @ months was @ for no brief intervention vs @ for the BNI group ( incidence rate ratio -LSB- IRR -RSB- , @ ; @ % CI , @-@ @ ) and @ for the MOTIV group ( IRR , @ ; @ % CI , @-@ @ ; P = @ for both comparisons vs no brief intervention ) .", "sentence_id": 10}
+{"abstract_id": "25096690", "label": "results", "text": "There were also no significant effects of BNI or MOTIV on any other outcome or in analyses stratified by main drug or drug use severity .", "sentence_id": 11}
+{"abstract_id": "25096690", "label": "conclusions", "text": "Brief intervention did not have efficacy for decreasing unhealthy drug use in primary care patients identified by screening .", "sentence_id": 12}
+{"abstract_id": "25096690", "label": "conclusions", "text": "These results do not support widespread implementation of illicit drug use and prescription drug misuse screening and brief intervention .", "sentence_id": 13}
+{"abstract_id": "24467642", "label": "objective", "text": "Increasing life expectancy of HIV-@-infected patients raises interest in how trial results apply to older patients .", "sentence_id": 0}
+{"abstract_id": "24467642", "label": "objective", "text": "This post-hoc analysis evaluated potential differences in efficacy and safety in older ( @ years ) versus younger ( < @ years ) patients in the ECHO and THRIVE trials over @ weeks .", "sentence_id": 1}
+{"abstract_id": "24467642", "label": "methods", "text": "HIV-infected , treatment-nave adults were randomized to receive rilpivirine ( RPV ) or efavirenz ( EFV ) , plus a background regimen .", "sentence_id": 2}
+{"abstract_id": "24467642", "label": "methods", "text": "Virologic response rates ( FDA snapshot analysis ; HIV-@ RNA < @ copies/mL ) were assessed at Week @ .", "sentence_id": 3}
+{"abstract_id": "24467642", "label": "methods", "text": "Total-body bone mineral density was evaluated at baseline and Week @ by dual-energy X-ray absorptiometry scans .", "sentence_id": 4}
+{"abstract_id": "24467642", "label": "methods", "text": "Serum concentrations of @-hydroxy vitamin D ( ECHO trial only ) were also measured at baseline , Week @ and Week @ .", "sentence_id": 5}
+{"abstract_id": "24467642", "label": "results", "text": "@ patients were treated .", "sentence_id": 6}
+{"abstract_id": "24467642", "label": "results", "text": "At Week @ , virologic response rates were similar between older ( @ % ) and younger ( @ % ) RPV-treated patients and numerically higher in older ( @ % ) versus younger ( @ % ) EFV-treated patients .", "sentence_id": 7}
+{"abstract_id": "24467642", "label": "results", "text": "No clinically relevant age-related differences were observed in immunologic responses .", "sentence_id": 8}
+{"abstract_id": "24467642", "label": "results", "text": "Small differences were noted in older versus younger patients in adverse events ( higher rates of depression , insomnia , and rash in older EFV-treated patients ) , laboratory abnormalities ( increased low-density lipoprotein cholesterol and hyperglycemia in older EFV-treated patients and increased amylase in older patients across treatments ) , bone mineral density ( larger decreases in older patients across treatments ) , and progression to severe vitamin D deficiency ( greater in older versus younger EFV-treated patients ) .", "sentence_id": 9}
+{"abstract_id": "24467642", "label": "conclusions", "text": "Efficacy and safety outcomes were generally similar in older versus younger patients in the ECHO and THRIVE trials .", "sentence_id": 10}
+{"abstract_id": "25253679", "label": "background", "text": "Although Muslim diabetic patients may be aware of their religious exemption from fasting , many still fast and adjust their medication regimens accordingly .", "sentence_id": 0}
+{"abstract_id": "25253679", "label": "background", "text": "Pharmacists have a significant potential to identify and prevent harm from medication misuse in Ramadan .", "sentence_id": 1}
+{"abstract_id": "25253679", "label": "objective", "text": "This study examines Egyptian pharmacists ' knowledge regarding management of diabetes during Ramadan .", "sentence_id": 2}
+{"abstract_id": "25253679", "label": "objective", "text": "It also explores pharmacists ' willingness to attend a @ day workshop on medication regimen adjustment during Ramadan .", "sentence_id": 3}
+{"abstract_id": "25253679", "label": "methods", "text": "Community pharmacies throughout Alexandria , Egypt .", "sentence_id": 4}
+{"abstract_id": "25253679", "label": "methods", "text": "A cross-sectional study using a pretested self-administered survey was conducted among a random sample of community pharmacists .", "sentence_id": 5}
+{"abstract_id": "25253679", "label": "methods", "text": "The survey included three knowledge questions relevant to counseling diabetic patients during Ramadan .", "sentence_id": 6}
+{"abstract_id": "25253679", "label": "methods", "text": "Questions covered the recommended timing and dosing for metformin and insulin as well as the safe blood glucose range required for diabetic patients to safely continue their fast .", "sentence_id": 7}
+{"abstract_id": "25253679", "label": "methods", "text": "Using logistic regression , a model was estimated to predict pharmacists ' willingness to attend a workshop on the adjustment of medication regimens during Ramadan .", "sentence_id": 8}
+{"abstract_id": "25253679", "label": "methods", "text": "Content analysis was used to analyze pharmacists ' answers to the question concerning what they would like the workshop to cover .", "sentence_id": 9}
+{"abstract_id": "25253679", "label": "methods", "text": "Pharmacists ' aggregate scores for all three diabetes management knowledge questions and pharmacists ' willingness to attend a workshop on the adjustment of medication regimens during Ramadan .", "sentence_id": 10}
+{"abstract_id": "25253679", "label": "results", "text": "Ninety three percent of the @ approached pharmacists agreed to participate .", "sentence_id": 11}
+{"abstract_id": "25253679", "label": "results", "text": "Forty three pharmacists ( @ % ) did not know the correct answer to any question , @ ( @ % ) @ answered one correctly , @ ( @ % ) answered two correctly and only @ ( @ % ) answered all @ three correctly .", "sentence_id": 12}
+{"abstract_id": "25253679", "label": "results", "text": "Confidence in therapeutic knowledge regarding medication regimen @ adjustment during Ramadan was not associated with the pharmacists ' knowledge of diabetes management during Ramadan .", "sentence_id": 13}
+{"abstract_id": "25253679", "label": "results", "text": "One hundred seventy five ( @ % ) pharmacists wanted to attend a workshop on adjusting medication regimens during Ramadan .", "sentence_id": 14}
+{"abstract_id": "25253679", "label": "results", "text": "This was significantly associated with pharmacists being Muslim ( OR @ , CI @-@ @ ) and of younger age ( OR @ = @ , CI @-@ @ ) .", "sentence_id": 15}
+{"abstract_id": "25253679", "label": "results", "text": "Pharmacists offered specific content and communication process @ suggestions for the workshop content .", "sentence_id": 16}
+{"abstract_id": "25253679", "label": "conclusions", "text": "This study identifies variability among community pharmacists ' knowledge of diabetes management during Ramadan .", "sentence_id": 17}
+{"abstract_id": "25253679", "label": "conclusions", "text": "It also shows willingness among the majority of pharmacists to learn more about the topic .", "sentence_id": 18}
+{"abstract_id": "24858202", "label": "objective", "text": "Data regarding long-term outcomes of neonates reaching viability following early preterm premature rupture of membranes ( PPROM ; < @ weeks at rupture ) are limited .", "sentence_id": 0}
+{"abstract_id": "24858202", "label": "objective", "text": "We hypothesized that babies delivered after early PPROM would have increased rates of major childhood morbidity compared with those with later PPROM ( @ weeks at rupture ) .", "sentence_id": 1}
+{"abstract_id": "24858202", "label": "methods", "text": "This was a secondary analysis of a multicenter randomized controlled trial of magnesium sulfate vs placebo for cerebral palsy prevention .", "sentence_id": 2}
+{"abstract_id": "24858202", "label": "methods", "text": "Women with singletons and PPROM of @-@ weeks were included .", "sentence_id": 3}
+{"abstract_id": "24858202", "label": "methods", "text": "All women delivered at @ weeks or longer .", "sentence_id": 4}
+{"abstract_id": "24858202", "label": "methods", "text": "Those with PPROM less than @ weeks ( cases ) were compared with women with PPROM at @-@ @ weeks ( controls ) .", "sentence_id": 5}
+{"abstract_id": "24858202", "label": "methods", "text": "Composite severe neonatal morbidity ( sepsis , severe intraventricular hemorrhage , periventricular leukomalacia , severe necrotizing enterocolitis , bronchopulmonary dysplasia , and/or death ) and composite severe childhood morbidity at age @ years ( moderate or severe cerebral palsy and/or Bayley II Infant and Toddler Development scores greater than @ SD below the mean ) were compared .", "sentence_id": 6}
+{"abstract_id": "24858202", "label": "results", "text": "A total of @ women ( @ early PPROM cases ) were included .", "sentence_id": 7}
+{"abstract_id": "24858202", "label": "results", "text": "Demographics were similar between the groups .", "sentence_id": 8}
+{"abstract_id": "24858202", "label": "results", "text": "Cases delivered earlier ( @ vs @ weeks , P < @ ) and had a longer rupture-to-delivery interval ( @ vs @ days , P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24858202", "label": "results", "text": "Case neonates had high rates of severe composite neonatal morbidity ( @ % vs @ % , P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24858202", "label": "results", "text": "Children with early PPROM had higher composite severe childhood morbidity ( @ % vs @ % , P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24858202", "label": "results", "text": "Early PPROM remained associated with composite severe childhood morbidity in multivariable models , even when controlling for delivery gestational age and other confounders .", "sentence_id": 12}
+{"abstract_id": "24858202", "label": "conclusions", "text": "Early PPROM is associated with high rates of neonatal morbidity .", "sentence_id": 13}
+{"abstract_id": "24858202", "label": "conclusions", "text": "Early childhood outcomes at age @ years remain poor compared with those delivered after later PPROM .", "sentence_id": 14}
+{"abstract_id": "24316517", "label": "objective", "text": "Obesity has been associated with changes in the composition and function of the intestinal microbiota .", "sentence_id": 0}
+{"abstract_id": "24316517", "label": "objective", "text": "Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice .", "sentence_id": 1}
+{"abstract_id": "24316517", "label": "objective", "text": "Hence , we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism .", "sentence_id": 2}
+{"abstract_id": "24316517", "label": "methods", "text": "In this single blinded randomized controlled trial , @ male obese subjects with metabolic syndrome were randomized to @ days of amoxicillin @ mg t.i.d. or @ days of vancomycin @ mg t.i.d.", "sentence_id": 3}
+{"abstract_id": "24316517", "label": "methods", "text": "At baseline and after @ week of therapy , fecal microbiota composition ( Human Intestinal Tract Chip phylogenetic microarray ) , fecal and plasma bile acid concentrations as well as insulin sensitivity ( hyperinsulinemic euglycemic clamp using -LSB- @,@ - ( @ ) H@ -RSB- - glucose tracer ) were measured .", "sentence_id": 4}
+{"abstract_id": "24316517", "label": "results", "text": "Vancomycin reduced fecal microbial diversity with a decrease of gram-positive bacteria ( mainly Firmicutes ) and a compensatory increase in gram-negative bacteria ( mainly Proteobacteria ) .", "sentence_id": 5}
+{"abstract_id": "24316517", "label": "results", "text": "Concomitantly , vancomycin decreased fecal secondary bile acids with a simultaneous postprandial increase in primary bile acids in plasma ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24316517", "label": "results", "text": "Moreover , changes in fecal bile acid concentrations were predominantly associated with altered Firmicutes .", "sentence_id": 7}
+{"abstract_id": "24316517", "label": "results", "text": "Finally , administration of vancomycin decreased peripheral insulin sensitivity ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24316517", "label": "results", "text": "Amoxicillin did not affect any of these parameters .", "sentence_id": 9}
+{"abstract_id": "24316517", "label": "conclusions", "text": "Oral administration of vancomycin significantly impacts host physiology by decreasing intestinal microbiota diversity , bile acid dehydroxylation and peripheral insulin sensitivity in subjects with metabolic syndrome .", "sentence_id": 10}
+{"abstract_id": "24316517", "label": "conclusions", "text": "These data show that intestinal microbiota , particularly of the Firmicutes phylum contributes to bile acid and glucose metabolism in humans .", "sentence_id": 11}
+{"abstract_id": "24316517", "label": "conclusions", "text": "This trial is registered at the Dutch Trial Register ( NTR@ ) .", "sentence_id": 12}
+{"abstract_id": "25198265", "label": "objective", "text": "To evaluate whether ondansetron or the combination of doxylamine and pyridoxine was superior for the treatment of nausea and vomiting of pregnancy .", "sentence_id": 0}
+{"abstract_id": "25198265", "label": "methods", "text": "This was a double-blind , randomized , controlled trial in which women with nausea and vomiting of pregnancy were assigned to @ mg of ondansetron plus a placebo tablet or @ mg pyridoxine plus @ mg of doxylamine for @ days .", "sentence_id": 1}
+{"abstract_id": "25198265", "label": "methods", "text": "The primary outcome was an improvement in nausea as reported on a @-mm visual analog scale ( VAS ) .", "sentence_id": 2}
+{"abstract_id": "25198265", "label": "methods", "text": "Secondary outcomes were a reduction in vomiting on the VAS and the proportion of patients reporting sedation or constipation while using either study regimen .", "sentence_id": 3}
+{"abstract_id": "25198265", "label": "results", "text": "Thirty-six women ( @ in each group ) were randomized to either ondansetron or pyridoxine and doxylamine , of whom @ ( @ % ) and @ ( @ % ) completed follow-up , respectively .", "sentence_id": 4}
+{"abstract_id": "25198265", "label": "results", "text": "There were no differences among the groups with regard to demographic characteristics or baseline nausea .", "sentence_id": 5}
+{"abstract_id": "25198265", "label": "results", "text": "Patients randomized to ondansetron were more likely to have an improvement in their baseline nausea as compared with those using pyridoxine and doxylamine over the course of @ days of treatment ( median VAS score decreased @ mm -LSB- interquartile range @-@ -RSB- compared with @ mm -LSB- @-@ -RSB- ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25198265", "label": "results", "text": "Furthermore , women using ondansetron reported less vomiting ( median VAS decreased @ -LSB- interquartile range @-@ -RSB- compared with @ -LSB- -@ to @ -RSB- ; P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25198265", "label": "results", "text": "There was no significant difference between the groups regarding sedation or constipation .", "sentence_id": 8}
+{"abstract_id": "25198265", "label": "conclusions", "text": "Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy .", "sentence_id": 9}
+{"abstract_id": "24290345", "label": "objective", "text": "Patients with diarrhoea during enteral nutrition ( EN ) have been shown to have low faecal bifidobacteria concentrations .", "sentence_id": 0}
+{"abstract_id": "24290345", "label": "objective", "text": "Oligofructose/inulin selectively stimulate the growth of bifidobacteria in healthy humans .", "sentence_id": 1}
+{"abstract_id": "24290345", "label": "objective", "text": "This study investigates the effect of additional oligofructose/inulin on the gastrointestinal microbiota , short-chain fatty acids ( SCFA ) and faecal output in patients receiving EN .", "sentence_id": 2}
+{"abstract_id": "24290345", "label": "methods", "text": "Adult patients in the intensive care unit ( ICU ) who were starting EN with a formula containing fibre were randomised to receive @g/d of additional oligofructose/inulin or an identically packaged placebo ( maltodextrin ) .", "sentence_id": 3}
+{"abstract_id": "24290345", "label": "methods", "text": "A fresh faecal sample was collected at baseline and following at least @ days of supplementation .", "sentence_id": 4}
+{"abstract_id": "24290345", "label": "methods", "text": "Faecal microbiota were analysed using fluorescent in-situ hybridisation and faecal output was monitored daily .", "sentence_id": 5}
+{"abstract_id": "24290345", "label": "results", "text": "Twenty-two patients ( mean age @ years ) completed at least @ days of intervention ( mean @ days ) .", "sentence_id": 6}
+{"abstract_id": "24290345", "label": "results", "text": "At the end of the intervention , there were no significant differences in the concentrations of bifidobacteria between the groups , after adjusting for baseline values ( oligofructose/inulin @ +@ , placebo @ +@ log@cells/g dry faeces , P > @ ) , but there were significantly lower concentrations of Faecalibacterium prausnitzii ( @ +@ vs. @ +@ log@cells/g , P = @ ) and Bacteroides-Prevotella ( @ +@ vs. @ +@ log@cells/g , P = @ ) in patients receiving additional oligofructose/inulin .", "sentence_id": 7}
+{"abstract_id": "24290345", "label": "results", "text": "There were no differences in faecal concentrations of any SCFA , secretory IgA , daily faecal score or incidence of diarrhoea between the two groups .", "sentence_id": 8}
+{"abstract_id": "24290345", "label": "conclusions", "text": "Additional oligofructose/inulin did not increase faecal bifidobacteria in critically ill patients receiving EN , although it did result in lower concentrations of F.prausnitzii and Bacteroides-Prevotella .", "sentence_id": 9}
+{"abstract_id": "24290345", "label": "conclusions", "text": "This trial is registered at http://controlled-trials.com .", "sentence_id": 10}
+{"abstract_id": "24290345", "label": "conclusions", "text": "Identifier : ISRCTN@ .", "sentence_id": 11}
+{"abstract_id": "25118263", "label": "objective", "text": "To quantify the visual functional changes caused by pinhole glasses .", "sentence_id": 0}
+{"abstract_id": "25118263", "label": "methods", "text": "Healthy subjects underwent ophthalmic examinations including uncorrected distance visual acuity ( UDVA ) and corrected near visual acuity ( CNVA ) , pupil size , depth of focus ( DOF ) , accommodative amplitude , visual field ( VF ) test , contrast sensitivity ( CS ) , and stereopsis .", "sentence_id": 1}
+{"abstract_id": "25118263", "label": "methods", "text": "Subjects underwent the same examinations while wearing pinhole glasses @ week later .", "sentence_id": 2}
+{"abstract_id": "25118263", "label": "results", "text": "Forty-eight eyes of @ subjects ( @ male and @ female ) with a mean age of @ years and a mean spherical equivalent of -@ diopters ( D ) were enrolled .", "sentence_id": 3}
+{"abstract_id": "25118263", "label": "results", "text": "The pinhole glasses significantly improved UDVA and CNVA ( logMAR ) from @ and @ to @ and @ , respectively .", "sentence_id": 4}
+{"abstract_id": "25118263", "label": "results", "text": "The pinhole glasses markedly enlarged pupils from @ mm photopic size to @ mm , very close to the mesopic size of @ mm .", "sentence_id": 5}
+{"abstract_id": "25118263", "label": "results", "text": "Mean DOF and accommodative amplitude also significantly increased by approximately @ % , while VF featured a general reduction of sensitivity .", "sentence_id": 6}
+{"abstract_id": "25118263", "label": "results", "text": "Mean deviation ( MD ) significantly decreased from -@ to -@ dB , and visual field index ( VFI ) decreased from @ % to @ % .", "sentence_id": 7}
+{"abstract_id": "25118263", "label": "results", "text": "The CS decreased significantly at all four spatial frequencies , and stereopsis deteriorated with pinhole glasses .", "sentence_id": 8}
+{"abstract_id": "25118263", "label": "conclusions", "text": "The pinhole glasses improved visual acuity , DOF , and accommodative amplitude ; however , they resulted in decreased visual quality including general reduction of VF sensitivity , CS , and stereopsis .", "sentence_id": 9}
+{"abstract_id": "25118263", "label": "conclusions", "text": "Therefore , particular attention is needed when wearing pinhole glasses while driving , playing sports , or working with instruments .", "sentence_id": 10}
+{"abstract_id": "25118263", "label": "conclusions", "text": "( ClinicalTrials.gov number , NCT@ . )", "sentence_id": 11}
+{"abstract_id": "24262496", "label": "objective", "text": "We compared slow vs fast shock wave frequency rates in disintegration of pediatric renal stones less than @ mm .", "sentence_id": 0}
+{"abstract_id": "24262496", "label": "methods", "text": "Our study included @ children with solitary @ to @ mm radiopaque renal stones treated with shock wave lithotripsy .", "sentence_id": 1}
+{"abstract_id": "24262496", "label": "methods", "text": "Patients were prospectively randomized into @ groups , ie those undergoing lithotripsy at a rate of @ shock waves per minute ( group @ , @ patients ) and those undergoing lithotripsy at a rate of @ shock waves per minute ( group @ , @ patients ) .", "sentence_id": 2}
+{"abstract_id": "24262496", "label": "methods", "text": "The @ groups were compared in terms of treatment success , anesthesia time , secondary procedures and efficiency quotient .", "sentence_id": 3}
+{"abstract_id": "24262496", "label": "results", "text": "Stone clearance rate was significantly higher in group @ ( @ % ) than in group @ ( @ % , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24262496", "label": "results", "text": "A total of @ patients in group @ ( @ % ) were rendered stone-free after @ session , @ required @ sessions and @ needed @ sessions , while shock wave lithotripsy failed in @ patients .", "sentence_id": 5}
+{"abstract_id": "24262496", "label": "results", "text": "By comparison , @ patients ( @ % ) in group @ were rendered stone-free after @ session , @ ( @ % ) required @ sessions and @ ( @ % ) needed @ sessions to become stone-free .", "sentence_id": 6}
+{"abstract_id": "24262496", "label": "results", "text": "Mean general anesthesia time was significantly longer in group @ ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24262496", "label": "results", "text": "Postoperatively @ patients in group @ and @ in group @ suffered low grade fever ( Clavien grade II ) .", "sentence_id": 8}
+{"abstract_id": "24262496", "label": "results", "text": "Significantly more secondary procedures ( percutaneous nephrolithotomy , repeat shock wave lithotripsy ) were required in group @ ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "24262496", "label": "results", "text": "The predominant stone analysis was calcium oxalate dihydrate in both groups .", "sentence_id": 10}
+{"abstract_id": "24262496", "label": "results", "text": "Efficiency quotient was @ and @ for group @ and group @ , respectively ( p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24262496", "label": "conclusions", "text": "In children with renal stones slow delivery rates of shock wave lithotripsy have better results regarding stone clearance than fast delivery rates .", "sentence_id": 12}
+{"abstract_id": "24424249", "label": "objective", "text": "To assess time to first achievement of clinically significant visual acuity ( VA ) gains from baseline in patients with retinal vein occlusion ( RVO ) receiving ranibizumab versus sham treatment .", "sentence_id": 0}
+{"abstract_id": "24424249", "label": "methods", "text": "Post hoc analyses of @ phase @ clinical trials assessing efficacy and safety of ranibizumab in patients with branch RVO ( Ranibizumab for the Treatment of Macular Edema following Branch Retinal Vein Occlusion : Evaluation of Efficacy and Safety -LSB- BRAVO -RSB- study ; NCT@ ) and central RVO ( Ranibizumab for the Treatment of Macular Edema after Central Retinal Vein Occlusion Study : Evaluation of Efficacy and Safety -LSB- CRUISE -RSB- ; NCT@ ) over @ months .", "sentence_id": 1}
+{"abstract_id": "24424249", "label": "methods", "text": "Seven hundred eighty-nine patients ( BRAVO , n = @ ; CRUISE , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24424249", "label": "methods", "text": "Randomization to monthly intraocular ranibizumab injections ( @ mg/@ @ mg ) or sham .", "sentence_id": 3}
+{"abstract_id": "24424249", "label": "methods", "text": "After @ monthly injections ( treatment period ) , patients meeting prespecified criteria received as-needed ( pro re nata -LSB- PRN -RSB- ) ranibizumab at their assigned dose ( sham patients , ranibizumab @ mg ) through month @ ( observation period ) .", "sentence_id": 4}
+{"abstract_id": "24424249", "label": "methods", "text": "BRAVO patients meeting specific eligibility criteria could receive rescue laser treatment once during the treatment and once during the observation periods .", "sentence_id": 5}
+{"abstract_id": "24424249", "label": "methods", "text": "Time to first gain of @ letters or more from baseline , analyzed using Kaplan-Meier methods .", "sentence_id": 6}
+{"abstract_id": "24424249", "label": "methods", "text": "To evaluate the effect of delaying ranibizumab treatment , sham patients ' VA data also were analyzed , with month @ considered as baseline to assess vision gains during the @ months of receiving ranibizumab PRN .", "sentence_id": 7}
+{"abstract_id": "24424249", "label": "results", "text": "Median time to first @-letter or more gain from baseline was @ ( sham ) , @ ( ranibizumab @ mg ) , and @ months ( ranibizumab @ mg ) in BRAVO and @ , @ , and @ months , respectively , in CRUISE .", "sentence_id": 8}
+{"abstract_id": "24424249", "label": "results", "text": "The cumulative proportion of patients who had ever gained @ letters or more from baseline by month @ was @ % ( sham ) , @ % ( ranibizumab @ mg ) , and @ % ( ranibizumab @ mg ) in BRAVO and @ % , @ % , and @ % , respectively , in CRUISE .", "sentence_id": 9}
+{"abstract_id": "24424249", "label": "results", "text": "After @ months of ranibizumab PRN treatment , a cumulative @ % ( BRAVO ) and @ % ( CRUISE ) of initially sham-treated patients ever gained @ letters or more .", "sentence_id": 10}
+{"abstract_id": "24424249", "label": "conclusions", "text": "This retrospective analysis shows that more than @ % of patients treated with monthly ranibizumab achieved clinically significant vision gains during the initial @ months of treatment , which largely were maintained using PRN treatment to @ months .", "sentence_id": 11}
+{"abstract_id": "24424249", "label": "conclusions", "text": "In comparison , less than @ % of patients initially randomized to sham ( and later receiving ranibizumab @ mg PRN treatment ) ever achieved clinically significant vision gains .", "sentence_id": 12}
+{"abstract_id": "24424249", "label": "conclusions", "text": "These results suggest that initiating treatment immediately after diagnosis may provide the greatest vision gains .", "sentence_id": 13}
+{"abstract_id": "24424249", "label": "conclusions", "text": "The potential benefits of early treatment should be evaluated further in prospective clinical studies .", "sentence_id": 14}
+{"abstract_id": "24604110", "label": "background", "text": "Although some clinical reports suggest patient-specific instrumentation in TKA may improve alignment , reduce surgical time , and lower hospital costs , it is unknown whether it improves pain - and function-related outcomes and gait .", "sentence_id": 0}
+{"abstract_id": "24604110", "label": "objective", "text": "We hypothesized that TKA performed with patient-specific instrumentation would improve patient-reported outcomes measured by validated scoring tools and level gait as ascertained with three-dimensional ( @-D ) analysis compared with conventional instrumentation @ months after surgery .", "sentence_id": 1}
+{"abstract_id": "24604110", "label": "methods", "text": "We randomized @ patients into two groups using either patient-specific instrumentation or conventional instrumentation .", "sentence_id": 2}
+{"abstract_id": "24604110", "label": "methods", "text": "Patients were evaluated preoperatively and @ months after surgery .", "sentence_id": 3}
+{"abstract_id": "24604110", "label": "methods", "text": "Assessment tools included subjective functional outcome and quality-of-life ( QOL ) scores using validated questionnaires ( New Knee Society Score ( ) -LSB- KSS -RSB- , Knee Injury and Osteoarthritis Outcome Score -LSB- KOOS -RSB- , and SF-@ ) .", "sentence_id": 4}
+{"abstract_id": "24604110", "label": "methods", "text": "In addition , gait analysis was evaluated with a @-D system during level walking .", "sentence_id": 5}
+{"abstract_id": "24604110", "label": "methods", "text": "The study was powered a priori at @ % to detect a difference in walking speed of @ m/second , which was considered a clinically important difference , and in a post hoc analysis at @ % to detect a difference of @ points in KSS .", "sentence_id": 6}
+{"abstract_id": "24604110", "label": "results", "text": "There were improvements from preoperatively to @ months postoperatively in functional scores , QOL , and knee kinematic and kinetic gait parameters during level walking .", "sentence_id": 7}
+{"abstract_id": "24604110", "label": "results", "text": "However , there was no difference between the patient-specific instrumentation and conventional instrumentation groups in KSS , KOOS , SF-@ , or @-D gait parameters .", "sentence_id": 8}
+{"abstract_id": "24604110", "label": "conclusions", "text": "Our observations suggest that patient-specific instrumentation does not confer a substantial advantage in early functional or gait outcomes after TKA .", "sentence_id": 9}
+{"abstract_id": "24604110", "label": "conclusions", "text": "It is possible that differences may emerge , and this study does not allow one to predict any additional variances in the intermediate followup period from @ months to @ year postoperatively .", "sentence_id": 10}
+{"abstract_id": "24604110", "label": "conclusions", "text": "However , the goals of the study were to investigate the recovery period as early pain and functional outcomes are becoming increasingly important to patients and surgeons .", "sentence_id": 11}
+{"abstract_id": "24604110", "label": "methods", "text": "Level I , therapeutic study .", "sentence_id": 12}
+{"abstract_id": "24604110", "label": "methods", "text": "See the Instructions to Authors for a complete description of levels of evidence .", "sentence_id": 13}
+{"abstract_id": "25434316", "label": "objective", "text": "Inadequate bowel cleaning leads to a suboptimal colonoscopic examination .", "sentence_id": 0}
+{"abstract_id": "25434316", "label": "objective", "text": "Gum chewing has been reported to have a favorable effect on postoperative bowel functions .", "sentence_id": 1}
+{"abstract_id": "25434316", "label": "objective", "text": "We conducted this study to establish if gum chewing added to high-dose senna before colonoscopy promotes bowel cleaning .", "sentence_id": 2}
+{"abstract_id": "25434316", "label": "methods", "text": "In this randomized controlled study , consecutive outpatients scheduled for elective colonoscopy were randomized into two groups .", "sentence_id": 3}
+{"abstract_id": "25434316", "label": "methods", "text": "Group @ patients ( n = @ ) used senna solution @ mL ( @ mg senna ) the night before colonoscopy .", "sentence_id": 4}
+{"abstract_id": "25434316", "label": "methods", "text": "The patients also used sennoside tablet @ mg daily for @ days before the colonoscopy .", "sentence_id": 5}
+{"abstract_id": "25434316", "label": "methods", "text": "Patients in group @ ( n = @ ) were additionally advised to chew sugarless gum half an hour three-times daily after meals for these @ days .", "sentence_id": 6}
+{"abstract_id": "25434316", "label": "methods", "text": "The overall quality of colonoscopy cleaning was evaluated using the Aronchick scale by a single endoscopist who was blinded to the intervention .", "sentence_id": 7}
+{"abstract_id": "25434316", "label": "methods", "text": "Difficulty of procedure , patients ' tolerance , and adverse events were also evaluated .", "sentence_id": 8}
+{"abstract_id": "25434316", "label": "results", "text": "A total @ patients were enrolled in the study .", "sentence_id": 9}
+{"abstract_id": "25434316", "label": "results", "text": "Superior cleaning was found in gum chewing group when compared with other group particularly in the cecum and ascending colon .", "sentence_id": 10}
+{"abstract_id": "25434316", "label": "results", "text": "Cecal intubation time was significantly shorter in the gum-chewing group ( @ @ and @ @ min , P = @ ) .", "sentence_id": 11}
+{"abstract_id": "25434316", "label": "results", "text": "Adverse events were more common in group @ compared to the gum-chewing group .", "sentence_id": 12}
+{"abstract_id": "25434316", "label": "conclusions", "text": "Gum chewing enhances colonoscopy bowel preparation quality .", "sentence_id": 13}
+{"abstract_id": "25434316", "label": "conclusions", "text": "Moreover , it is a physiologically sound , safe , and an inexpensive part of the colonoscopy bowel preparation .", "sentence_id": 14}
+{"abstract_id": "25434316", "label": "conclusions", "text": "Gum chewing could be advised in addition to high-dose senna containing bowel preparation .", "sentence_id": 15}
+{"abstract_id": "24343961", "label": "background", "text": "Individuals with borderline personality disorder ( BPD ) and comorbid post-traumatic stress disorder ( PTSD ) have a worse prognosis than individuals with BPD alone .", "sentence_id": 0}
+{"abstract_id": "24343961", "label": "background", "text": "A common view is that the emotional instability and impulsivity of BPD should be treated before attempting to address trauma .", "sentence_id": 1}
+{"abstract_id": "24343961", "label": "background", "text": "However , PTSD symptoms may interfere with patients ' ability to benefit from such ` stabilizing ' treatments .", "sentence_id": 2}
+{"abstract_id": "24343961", "label": "methods", "text": "The effect of BPD-PTSD comorbidity on self-harm and BPD symptom outcomes was evaluated in @ patients receiving dialectical behaviour therapy , using multilevel modelling .", "sentence_id": 3}
+{"abstract_id": "24343961", "label": "results", "text": "Patients with comorbid BPD-PTSD showed a trend towards elevated BPD symptoms throughout the treatment year ( = @ , @ % CI = -@ -@ , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "24343961", "label": "results", "text": "There was a three-way interaction between PTSD comorbidity , treatment completion and time , whereby PTSD comorbidity was associated with less reduction in self-harm frequency over time , but only in those completing the full @ months of treatment ( incident risk ratio = @ , @ % CI = @-@ @ , p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24343961", "label": "conclusions", "text": "Patients with comorbid PTSD had a poorer outcome from dialectical behaviour therapy than those with BPD alone , possibly because of the negative impact of unaddressed trauma .", "sentence_id": 6}
+{"abstract_id": "24343961", "label": "conclusions", "text": "The results provide further grounds for recently developed treatments targeting BPD traits and PTSD symptoms simultaneously .", "sentence_id": 7}
+{"abstract_id": "24958577", "label": "background", "text": "Response-dose ratio ( RDR ) and cumulative provocative dosage ( PD ) are useful indices reflecting airway responsiveness in asthma .", "sentence_id": 0}
+{"abstract_id": "24958577", "label": "objective", "text": "To compare the diagnostic value of RDR and PD , by conducting leukotriene D@ ( LTD@-BPT ) and methacholine bronchial provocation test ( MCh-BPT ) , in different asthma control levels .", "sentence_id": 1}
+{"abstract_id": "24958577", "label": "methods", "text": "Healthy subjects and asthmatic patients underwent LTD@-BPT and MCh-BPT , at @-@-day interval .", "sentence_id": 2}
+{"abstract_id": "24958577", "label": "methods", "text": "This entailed assessment of the distribution characteristics , correlation , and diagnostic value of PD inducing @ % fall in forced expiratory volume in one second ( PD@FEV@ ) and the RDR , defined as FEV@ fall ( % ) at the final step divided by the corresponding provocative dosage .", "sentence_id": 3}
+{"abstract_id": "24958577", "label": "results", "text": "Twenty uncontrolled , @ partly controlled , @ controlled asthmatics , and @ healthy subjects were enrolled .", "sentence_id": 4}
+{"abstract_id": "24958577", "label": "results", "text": "Log@RDR was positively correlated with log@PD@FEV@ in both BPTs ( all P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24958577", "label": "results", "text": "Poorer asthma control was associated with significantly lower PD@FEV@ and higher RDR ( both P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24958577", "label": "results", "text": "The differences in PD@FEV@ and RDR between partly controlled and controlled asthma were unremarkable ( both P > @ ) .", "sentence_id": 7}
+{"abstract_id": "24958577", "label": "results", "text": "Compared with log@PD@FEV@ , the log@RDR yielded similar diagnostic values in both BPTs .", "sentence_id": 8}
+{"abstract_id": "24958577", "label": "results", "text": "A lower percentile of RDR ( @th percentile ) was associated with higher baseline FEV@ ( P < @ ) and an increased proportion of well-controlled asthmatic patients .", "sentence_id": 9}
+{"abstract_id": "24958577", "label": "results", "text": "The combination of RDR and PD@FEV@ led to an increased diagnostic value compared with either parameter alone .", "sentence_id": 10}
+{"abstract_id": "24958577", "label": "conclusions", "text": "RDR is a surrogate of PD@FEV@ for BPTs in asthma .", "sentence_id": 11}
+{"abstract_id": "24958577", "label": "conclusions", "text": "This finding was not modified by different asthma control levels or the types of bronchoprovocants .", "sentence_id": 12}
+{"abstract_id": "25787197", "label": "background", "text": "In a previous randomized trial , we found that percutaneous coronary intervention ( PCI ) was not inferior to coronary artery bypass grafting ( CABG ) for the treatment of unprotected left main coronary artery stenosis at @ year .", "sentence_id": 0}
+{"abstract_id": "25787197", "label": "objective", "text": "This study sought to determine the @-year outcomes of PCI compared with CABG for the treatment of unprotected left main coronary artery stenosis .", "sentence_id": 1}
+{"abstract_id": "25787197", "label": "methods", "text": "We randomly assigned @ patients with unprotected left main coronary artery stenosis to undergo PCI with a sirolimus-eluting stent ( n = @ ) or CABG ( n = @ ) .", "sentence_id": 2}
+{"abstract_id": "25787197", "label": "methods", "text": "The primary endpoint was a major adverse cardiac or cerebrovascular event ( MACCE : a composite of death from any cause , myocardial infarction , stroke , or ischemia-driven target vessel revascularization ) and compared on an intention-to-treat basis .", "sentence_id": 3}
+{"abstract_id": "25787197", "label": "results", "text": "At @ years , MACCE occurred in @ patients in the PCI group and @ patients in the CABG group ( cumulative event rates of @ % and @ % , respectively ; hazard ratio -LSB- HR -RSB- : @ ; @ % confidence interval -LSB- CI -RSB- : @ to @ ; p = @ ) .", "sentence_id": 4}
+{"abstract_id": "25787197", "label": "results", "text": "The @ groups did not differ significantly in terms of death from any cause , myocardial infarction , or stroke as well as their composite ( @ % and @ % ; HR , @ ; @ % CI , @ to @ ; p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25787197", "label": "results", "text": "Ischemia-driven target vessel revascularization occurred more frequently in the PCI group than in the CABG group ( @ % and @ % , respectively ; HR : @ ; @ % CI : @ to @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25787197", "label": "conclusions", "text": "During @ years of follow-up , our study did not show significant difference regarding the rate of MACCE between patients who underwent PCI with a sirolimus-eluting stent and those who underwent CABG .", "sentence_id": 7}
+{"abstract_id": "25787197", "label": "conclusions", "text": "However , considering the limited power of our study , our results should be interpreted with caution .", "sentence_id": 8}
+{"abstract_id": "25787197", "label": "conclusions", "text": "( Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease -LSB- PRECOMBAT -RSB- ; NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "25404659", "label": "objective", "text": "To evaluate @ - and @-month weight-loss outcomes achieved when physicians refer overweight/obese patients to an automated @-month Internet-based behavioral weight-loss intervention .", "sentence_id": 0}
+{"abstract_id": "25404659", "label": "methods", "text": "A total of @ patients age @-@ years with a BMI between @ and @ kg/m ( @ ) and access to a personal computer and the Internet were randomly assigned to @ months of Internet behavioral intervention ( IBI ; n = @ ) with @ weekly videos teaching behavioral weight-loss skills , a platform for submitting self-monitored data , and automated feedback or an education-only Internet-delivered eating and activity control group ( IDEA ; n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25404659", "label": "methods", "text": "Outcome measures were weight loss after @ months ( primary outcome ) and @ months and changes in weight-control behaviors ( secondary outcomes ) .", "sentence_id": 2}
+{"abstract_id": "25404659", "label": "results", "text": "In intent-to-treat analyses with baseline weight carried forward for missing data , IBI produced significantly larger mean ( SD ) weight losses than IDEA at @ months ( @ kg -LSB- @ -RSB- vs. @ kg -LSB- @ -RSB- ) and @ months ( @ kg -LSB- @ -RSB- vs. @ kg -LSB- @ -RSB- ) ( P < @ ) .", "sentence_id": 3}
+{"abstract_id": "25404659", "label": "results", "text": "Participants in IBI compared with IDEA were also more likely to achieve a clinically significant weight loss of @ % of initial body weight at @ months ( @ vs. @ % ) and @ months ( @ vs. @ % ) ( P < @ ) and reported more frequent use of weight control-related strategies .", "sentence_id": 4}
+{"abstract_id": "25404659", "label": "conclusions", "text": "Physician referral to an Internet-based behavioral weight-loss intervention produced clinically significant weight loss for over half of the patients studied .", "sentence_id": 5}
+{"abstract_id": "25404659", "label": "conclusions", "text": "Further research is needed to determine the effectiveness of implementing this intervention more broadly within diverse health care settings .", "sentence_id": 6}
+{"abstract_id": "25090414", "label": "background", "text": "We aimed to determine the effects of treatment with intravenous immunoglobulin on bacterial infections in patients with hypogammaglobulinemia ( HGG ) after lung transplantation .", "sentence_id": 0}
+{"abstract_id": "25090414", "label": "methods", "text": "We performed a randomized , double-blind , placebo-controlled two-period crossover trial of immune globulin intravenous ( IVIG ) , @ % Purified ( Gamunex , Bayer , Elkhart , IN ) monthly in eleven adults who had undergone lung transplantation more than three months previously .", "sentence_id": 1}
+{"abstract_id": "25090414", "label": "methods", "text": "We randomized study participants to three doses of IVIG ( or @ % albumin solution ( placebo ) ) given four weeks apart followed by a twelve week washout and then three doses of placebo ( or IVIG ) .", "sentence_id": 2}
+{"abstract_id": "25090414", "label": "methods", "text": "The primary outcome was the number of bacterial infections within each treatment period .", "sentence_id": 3}
+{"abstract_id": "25090414", "label": "results", "text": "IVIG had no effect on the number of bacterial infections during the treatment period ( @ during IVIG and @ during placebo ; odds ratio @ , @ % confidence interval @ to @ , p = @ ) .", "sentence_id": 4}
+{"abstract_id": "25090414", "label": "results", "text": "There were no effects on other infections , use of antibiotics , or lung function .", "sentence_id": 5}
+{"abstract_id": "25090414", "label": "results", "text": "IVIG significantly increased trough IgG levels at all time points ( least square means , @ mg/dl during IVIG and @ mg/dl during placebo , p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25090414", "label": "results", "text": "Four serious adverse events ( resulting in hospitalization ) occurred during the treatment periods ( @ during active treatment and @ during the placebo period , p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25090414", "label": "results", "text": "Chills , flushing , and nausea occurred during one infusion of IVIG .", "sentence_id": 8}
+{"abstract_id": "25090414", "label": "conclusions", "text": "Treatment with IVIG did not reduce the short-term risk of bacterial infection in patients with HGG after lung transplantation .", "sentence_id": 9}
+{"abstract_id": "25090414", "label": "conclusions", "text": "The clinical efficacy of immunoglobulin supplementation in HGG related to lung transplantation over the long term or with recurrent infections is unknown .", "sentence_id": 10}
+{"abstract_id": "24573743", "label": "background", "text": "Colorectal cancer ( CRC ) is the fourth leading cause of cancer-related deaths worldwide .", "sentence_id": 0}
+{"abstract_id": "24573743", "label": "background", "text": "The combination of oxaliplatin-based treatments ( oxaliplatin plus infusional @-fluorouracil and leucovorin -LSB- FOLFOX -RSB- or oxaliplatin plus capecitabine -LSB- CapeOX -RSB- ) and bevacizumab is a standard chemotherapy regimen for metastatic CRC ( mCRC ) .", "sentence_id": 1}
+{"abstract_id": "24573743", "label": "background", "text": "However , several clinical studies that tested S-@ plus oxaliplatin ( SOX ) indicate that SOX is also a treatment option for mCRC .", "sentence_id": 2}
+{"abstract_id": "24573743", "label": "background", "text": "TSU-@ is an oral compound that inhibits vascular endothelial growth factor receptor and platelet-derived growth factor receptor .", "sentence_id": 3}
+{"abstract_id": "24573743", "label": "background", "text": "The recommended dose of TSU-@ + SOX was previously determined in a phase I study of mCRC patients .", "sentence_id": 4}
+{"abstract_id": "24573743", "label": "background", "text": "The goal of this trial was to evaluate the efficacy of TSU-@ in combination with SOX .", "sentence_id": 5}
+{"abstract_id": "24573743", "label": "methods", "text": "This open-label multicenter randomized phase II trial was performed in Korea .", "sentence_id": 6}
+{"abstract_id": "24573743", "label": "methods", "text": "Treatment-naive mCRC patients with a performance status of @ or @ were randomized in a @:@ ratio to receive either TSU-@ + SOX or SOX alone .", "sentence_id": 7}
+{"abstract_id": "24573743", "label": "methods", "text": "The primary endpoint was progression-free survival ( PFS ) .", "sentence_id": 8}
+{"abstract_id": "24573743", "label": "results", "text": "A total of @ patients ( TSU-@ + SOX , @ patients ; SOX alone , @ patients ) were randomized .", "sentence_id": 9}
+{"abstract_id": "24573743", "label": "results", "text": "The median PFS was @ months in the TSU-@ + SOX group ( hazard ratio -LSB- HR -RSB- , @ ) and @ months in the SOX group ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "24573743", "label": "results", "text": "The most frequent grade @ and @ adverse events were thrombocytopenia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , neutropenia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , and anemia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) .", "sentence_id": 11}
+{"abstract_id": "24573743", "label": "results", "text": "We observed a difference between the @ groups for all grades of anemia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , diarrhea ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , vomiting ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) , and chromaturia ( @ % -LSB- TSU-@ + SOX -RSB- vs. @ % -LSB- SOX -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "24573743", "label": "results", "text": "Analysis using a Cox proportional hazard model showed that baseline interleukin @ ( IL-@ ) levels were associated with a survival benefit of TSU-@ ( p = @ ) .", "sentence_id": 13}
+{"abstract_id": "24573743", "label": "conclusions", "text": "TSU-@ + SOX had a favorable safety profile .", "sentence_id": 14}
+{"abstract_id": "24573743", "label": "conclusions", "text": "However , TSU-@ did not have a synergistic effect on the efficacy of SOX .", "sentence_id": 15}
+{"abstract_id": "24573743", "label": "conclusions", "text": "The baseline serum IL-@ level could be a prognostic factor for TSU-@ efficacy .", "sentence_id": 16}
+{"abstract_id": "24601887", "label": "background", "text": "This prospective , observer-blinded , randomised , multicentre study aimed at determining the non-inferiority of @ mg of plain @ % @-chloroprocaine vs. @ mg of @ % plain bupivacaine in terms of sensory block onset time at T@ after spinal injection .", "sentence_id": 0}
+{"abstract_id": "24601887", "label": "background", "text": "The study hypothesis was that the difference in onset times of sensory block to T@ between the two drugs is @ min .", "sentence_id": 1}
+{"abstract_id": "24601887", "label": "methods", "text": "One hundred and thirty patients undergoing lower abdominal or lower limb procedures ( @ min ) were randomised to receive one of two treatments : @ mg of plain @ % @-chloroprocaine ( Group C , n = @ ) or @ mg of plain @ % bupivacaine ( Group B , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24601887", "label": "methods", "text": "Times to sensory and motor block onsets , maximum sensory block level , readiness for surgery , regression of sensory and motor blocks , first analgesic requirements , unassisted ambulation , home discharge , and side effects after @ h and @ days were registered blindly .", "sentence_id": 3}
+{"abstract_id": "24601887", "label": "results", "text": "Chloroprocaine was comparable with plain @ % bupivacaine in terms of time to sensory block at T@ level .", "sentence_id": 4}
+{"abstract_id": "24601887", "label": "results", "text": "Group C showed faster onsets of motor block ( @ vs. @ min ) , maximum sensory block level ( @ vs. @ min ) , resolution of sensory ( @ vs. @ min ) and motor ( @ vs. @ min ) blocks , unassisted ambulation ( @ vs. @ min ) , first analgesic requirement ( @ vs. @ min ) , and home discharge ( @ vs. @ min ) ( all comparisons , P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24601887", "label": "results", "text": "No chloroprocaine patient developed transient neurological symptoms .", "sentence_id": 6}
+{"abstract_id": "24601887", "label": "conclusions", "text": "Spinal anaesthesia with @ mg of plain @ % @-chloroprocaine is similar to @ mg of plain @ % bupivacaine in terms of onset of sensory block at T@ but shows quicker recovery from anaesthesia than with @ % bupivacaine .", "sentence_id": 7}
+{"abstract_id": "25218610", "label": "objective", "text": "To evaluate the long-term safety and efficacy of prolonged-release oxycodone/naloxone ( OXN PR ) and its impact on quality of life ( QoL ) , in patients with moderate-to-severe cancer pain .", "sentence_id": 0}
+{"abstract_id": "25218610", "label": "methods", "text": "This was an open-label extension ( OLE ) of a @ week , randomized , double-blind ( DB ) study in which patients with moderate-to-severe cancer pain had been randomized to OXN PR or oxycodone PR ( OxyPR ) .", "sentence_id": 1}
+{"abstract_id": "25218610", "label": "methods", "text": "During the OLE phase , patients were treated with OXN PR capsules ( @/@ mg/day ) for @ weeks .", "sentence_id": 2}
+{"abstract_id": "25218610", "label": "methods", "text": "Outcome measures included safety , efficacy and QoL .", "sentence_id": 3}
+{"abstract_id": "25218610", "label": "results", "text": "One hundred and twenty-eight patients entered the OLE , average pain scores based on the modified Brief Pain Inventory-Short Form were low and stable over the @-week period .", "sentence_id": 4}
+{"abstract_id": "25218610", "label": "results", "text": "The improvement in bowel function and constipation symptoms as measured by the Bowel Function Index and patient assessment of constipation in patients treated with OXN PR during the @-week DB study was maintained .", "sentence_id": 5}
+{"abstract_id": "25218610", "label": "results", "text": "In patients treated with OxyPR during the DB phase , bowel function and constipation symptoms were improved during the OLE .", "sentence_id": 6}
+{"abstract_id": "25218610", "label": "results", "text": "In the DB and in the OLE , health status and QoL were similar for patients treated with OXN PR and OxyPR .", "sentence_id": 7}
+{"abstract_id": "25218610", "label": "results", "text": "There were no unexpected safety or tolerability issues .", "sentence_id": 8}
+{"abstract_id": "25218610", "label": "conclusions", "text": "In patients with moderate-to-severe cancer pain , long-term use of OXN PR is well tolerated and effective , resulting in sustained analgesia , improved bowel function and improved symptoms of constipation .", "sentence_id": 9}
+{"abstract_id": "25337988", "label": "background", "text": "Research to assess the effect of interventions to improve the processes of shared decision making and self-management directed at health care professionals is limited .", "sentence_id": 0}
+{"abstract_id": "25337988", "label": "background", "text": "Using the protocol of Intervention Mapping , a Web-based intervention directed at health care professionals was developed to complement and optimize health services in patient-centered care .", "sentence_id": 1}
+{"abstract_id": "25337988", "label": "objective", "text": "The objective of the Web-based intervention was to increase health care professionals ' intention and encouraging behavior toward patient self-management , following cardiovascular risk management guidelines .", "sentence_id": 2}
+{"abstract_id": "25337988", "label": "methods", "text": "A randomized controlled trial was used to assess the effect of a theory-based intervention , using a pre-test and post-test design .", "sentence_id": 3}
+{"abstract_id": "25337988", "label": "methods", "text": "The intervention website consisted of a module to help improve professionals ' behavior , a module to increase patients ' intention and risk-reduction behavior toward cardiovascular risk , and a parallel module with a support system for the health care professionals .", "sentence_id": 4}
+{"abstract_id": "25337988", "label": "methods", "text": "Health care professionals ( n = @ ) were recruited online and randomly allocated to the intervention group ( n = @ ) or ( waiting list ) control group ( n = @ ) , and invited their patients to participate .", "sentence_id": 5}
+{"abstract_id": "25337988", "label": "methods", "text": "The outcome was improved professional behavior toward health education , and was self-assessed through questionnaires based on the Theory of Planned Behavior .", "sentence_id": 6}
+{"abstract_id": "25337988", "label": "methods", "text": "Social-cognitive determinants , intention and behavior were measured pre-intervention and at @-year follow-up .", "sentence_id": 7}
+{"abstract_id": "25337988", "label": "results", "text": "The module to improve professionals ' behavior was used by @ % ( @/@ ) of the health care professionals in the intervention group .", "sentence_id": 8}
+{"abstract_id": "25337988", "label": "results", "text": "The module to support the health professional in encouraging behavior toward patients was used by @ % ( @/@ ) .", "sentence_id": 9}
+{"abstract_id": "25337988", "label": "results", "text": "The module to improve patients ' risk-reduction behavior was provided to @ % ( @/@ ) of patients .", "sentence_id": 10}
+{"abstract_id": "25337988", "label": "results", "text": "In @ of every @ patients , the guideline for cardiovascular risk management was used .", "sentence_id": 11}
+{"abstract_id": "25337988", "label": "results", "text": "The Web-based intervention was poorly used .", "sentence_id": 12}
+{"abstract_id": "25337988", "label": "results", "text": "In the intervention group , no differences in social-cognitive determinants , intention and behavior were found for health care professionals , compared with the control group .", "sentence_id": 13}
+{"abstract_id": "25337988", "label": "results", "text": "We narrowed the intervention group and no significant differences were found in intention and behavior , except for barriers .", "sentence_id": 14}
+{"abstract_id": "25337988", "label": "results", "text": "Results showed a significant overall difference in barriers between the intervention and the control group ( F@ = @ , P = @ ) .", "sentence_id": 15}
+{"abstract_id": "25337988", "label": "conclusions", "text": "The intervention was used by less than half of the participants and did not improve health care professionals ' and patients ' cardiovascular risk-reduction behavior .", "sentence_id": 16}
+{"abstract_id": "25337988", "label": "conclusions", "text": "The website was not used intensively because of time and organizational constraints .", "sentence_id": 17}
+{"abstract_id": "25337988", "label": "conclusions", "text": "Professionals in the intervention group experienced higher levels of barriers to encouraging patients , than professionals in the control group .", "sentence_id": 18}
+{"abstract_id": "25337988", "label": "conclusions", "text": "No improvements were detected in the processes of shared decision making and patient self-management .", "sentence_id": 19}
+{"abstract_id": "25337988", "label": "conclusions", "text": "Although participant education level was relatively high and the intervention was pre-tested , it is possible that the way the information was presented could be the reason for low participation and high dropout .", "sentence_id": 20}
+{"abstract_id": "25337988", "label": "conclusions", "text": "Further research embedded in professionals ' regular consultations with patients is required with specific emphasis on the processes of dissemination and implementation of innovations in patient-centered care .", "sentence_id": 21}
+{"abstract_id": "24833327", "label": "background", "text": "Although high-dose N-acetylcysteine ( NAC ) has been suggested to reduce COPD exacerbations , it is unclear which category of patients with COPD would benefit most from NAC treatment .", "sentence_id": 0}
+{"abstract_id": "24833327", "label": "background", "text": "The objective of this study was to compare the effect of high-dose NAC ( @ mg bid ) between high-risk and low-risk Chinese patients with COPD .", "sentence_id": 1}
+{"abstract_id": "24833327", "label": "methods", "text": "Patients with spirometry-confirmed stable COPD were randomized to treatment with either NAC @ mg bid or placebo in addition to their usual treatments .", "sentence_id": 2}
+{"abstract_id": "24833327", "label": "methods", "text": "Patients were followed up every @ weeks for a total of @ year .", "sentence_id": 3}
+{"abstract_id": "24833327", "label": "methods", "text": "Further analysis was performed according to each patient 's exacerbation risk at baseline as defined by the current GOLD ( Global Initiative for Chronic Obstructive Lung Disease ) strategy to analyze the effect of high-dose NAC in high-risk and low-risk patients .", "sentence_id": 4}
+{"abstract_id": "24833327", "label": "results", "text": "Of the @ patients with COPD randomized ( men , @ % ; mean age , @ @ years ; prebronchodilator FEV , @ @ % ; baseline characteristics comparable between treatment groups ) , @ ( NAC , @ ; placebo , @ ) completed the @-year study .", "sentence_id": 5}
+{"abstract_id": "24833327", "label": "results", "text": "For high-risk patients ( n = @ ) , high-dose NAC compared with placebo significantly reduced exacerbation frequency ( @ vs @ -LSB- P = @ -RSB- and @ vs @ -LSB- P = @ -RSB- at @ and @ months , respectively ) , prolonged time to first exacerbation ( P = @ ) , and increased the probability of being exacerbation free at @ year ( @ % vs @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24833327", "label": "results", "text": "This beneficial effect of high-dose NAC vs placebo was not significant in low-risk patients .", "sentence_id": 7}
+{"abstract_id": "24833327", "label": "conclusions", "text": "High-dose NAC ( @ mg bid ) for @ year reduces exacerbations and prolongs time to first exacerbation in high-risk but not in low-risk Chinese patients with COPD .", "sentence_id": 8}
+{"abstract_id": "25500097", "label": "background", "text": "Evidence-based preventive services for early detection of cancer and other health conditions offer profound health benefits , yet Americans receive only half of indicated services .", "sentence_id": 0}
+{"abstract_id": "25500097", "label": "background", "text": "Policy initiatives promote the adoption of information technologies to engage patients in care .", "sentence_id": 1}
+{"abstract_id": "25500097", "label": "background", "text": "We developed a theory-driven interactive preventive health record ( IPHR ) to engage patients in health promotion .", "sentence_id": 2}
+{"abstract_id": "25500097", "label": "background", "text": "The model defines five levels of functionality : ( @ ) collecting patient information , ( @ ) integrating with electronic health records ( EHRs ) , ( @ ) translating information into lay language , ( @ ) providing individualized , guideline-based clinical recommendations , and ( @ ) facilitating patient action .", "sentence_id": 3}
+{"abstract_id": "25500097", "label": "background", "text": "It is hypothesized that personal health records ( PHRs ) with these higher levels of functionality will inform and activate patients in ways that simpler PHRs can not .", "sentence_id": 4}
+{"abstract_id": "25500097", "label": "background", "text": "However , realizing this vision requires both technological advances and effective implementation based upon clinician and practice engagement .", "sentence_id": 5}
+{"abstract_id": "25500097", "label": "methods", "text": "We are starting a two-phase , mixed-method trial to evaluate whether the IPHR is scalable across a large number of practices and how its uptake differs for minority and disadvantaged patients .", "sentence_id": 6}
+{"abstract_id": "25500097", "label": "methods", "text": "In phase @ , @ practices from three practice-based research networks will be randomized to add IPHR functionality to their PHR versus continue to use their existing PHR .", "sentence_id": 7}
+{"abstract_id": "25500097", "label": "methods", "text": "Throughout the study , we will engage intervention practices to locally tailor IPHR content and learn how to integrate new functions into their practice workflow .", "sentence_id": 8}
+{"abstract_id": "25500097", "label": "methods", "text": "In phase @ , the IPHR to all nonintervention practices to observe whether the IPHR can be implemented more broadly ( Scalability ) .", "sentence_id": 9}
+{"abstract_id": "25500097", "label": "methods", "text": "Phase @ will feature an implementation assessment in intervention practices , based on the RE-AIM model , to measure Reach ( creation of IPHR accounts by patients ) , Adoption ( practice decision to use the IPHR ) , Implementation ( consistency , fidelity , barriers , and facilitators of use ) , and Maintenance ( sustained use ) .", "sentence_id": 10}
+{"abstract_id": "25500097", "label": "methods", "text": "The incremental effect of the IPHR on receipt of cancer screening tests and shared decision-making compared to traditional PHRs will assess Effectiveness .", "sentence_id": 11}
+{"abstract_id": "25500097", "label": "methods", "text": "In phase @ , we will assess similar outcomes as phase @ except for effectiveness .", "sentence_id": 12}
+{"abstract_id": "25500097", "label": "conclusions", "text": "This study will yield information about the effectiveness of new health information technologies designed to actively engage patients in their care as well as information about how to effectively implement and disseminate PHRs by engaging clinicians .", "sentence_id": 13}
+{"abstract_id": "24983709", "label": "background", "text": "Detailed characterization of asthma phenotypes is essential for identification of responder populations to allow directed personalized medical intervention .", "sentence_id": 0}
+{"abstract_id": "24983709", "label": "objective", "text": "The aim of this study was to identify distinctive patient characteristics within subgroups of a well-characterized severe asthma population at risk for exacerbations and to determine the treatment response within each subgroup .", "sentence_id": 1}
+{"abstract_id": "24983709", "label": "methods", "text": "A supervised cluster analysis with recursive partitioning approach was applied to data from the Dose Ranging Efficacy And safety with Mepolizumab ( DREAM ) study to identify characteristics that maximized the differences across subgroups .", "sentence_id": 2}
+{"abstract_id": "24983709", "label": "methods", "text": "Exacerbation rate ratios were calculated for each cluster comparing mepolizumab versus placebo .", "sentence_id": 3}
+{"abstract_id": "24983709", "label": "results", "text": "Three predictors were identified in four primary clusters : blood eosinophils , airway reversibility , and body mass index .", "sentence_id": 4}
+{"abstract_id": "24983709", "label": "results", "text": "The reduction in exacerbations was significantly greater in patients who received mepolizumab ( clusters @ , @ , and @ ) with raised eosinophils ( responder population ) .", "sentence_id": 5}
+{"abstract_id": "24983709", "label": "results", "text": "Cluster @ with low airway reversibility ( mean , @ % ) had a @ % reduction in exacerbations .", "sentence_id": 6}
+{"abstract_id": "24983709", "label": "results", "text": "These patients more frequently reported sinusitis and nasal polyposis .", "sentence_id": 7}
+{"abstract_id": "24983709", "label": "results", "text": "Those with higher airway reversibility ( mean , @ % ) were further split by body mass index .", "sentence_id": 8}
+{"abstract_id": "24983709", "label": "results", "text": "The nonobese versus obese ( clusters @ and @ ) had a @ and @ % reduction in exacerbations , respectively .", "sentence_id": 9}
+{"abstract_id": "24983709", "label": "results", "text": "Cluster @ also had patients with more comorbidities , including hypertension , weight gain , and anxiety .", "sentence_id": 10}
+{"abstract_id": "24983709", "label": "conclusions", "text": "Using supervised cluster analysis helped identify specific patient characteristics related to disease and therapeutic response .", "sentence_id": 11}
+{"abstract_id": "24983709", "label": "conclusions", "text": "Patients with eosinophilic inflammation received significant therapeutic benefit with mepolizumab , and responses differed within clusters .", "sentence_id": 12}
+{"abstract_id": "24983709", "label": "conclusions", "text": "Clinical trial registered with www.clinicaltrials.gov ( NCT@ ) .", "sentence_id": 13}
+{"abstract_id": "25804039", "label": "objective", "text": "To study a trend in active sacroiliitis ( ASI ) in patients with axial spondyloarthritis ( axSpA ) during different short-term regimens using etoricoxib ( ET ) @ mg .", "sentence_id": 0}
+{"abstract_id": "25804039", "label": "methods", "text": "Forty patients with axSpA , including @ with ankylosing spondyloarthritis ) , and ASI ( sacroiliac joint ( SIJ ) osteitis as evidenced by magnetic resonance imaging ) were examined and then randomized to @ groups : @ ) @ patients who took ET @ mg four days or more a week ; @ ) @ patients who received ET @ mg @ days or less a week .", "sentence_id": 1}
+{"abstract_id": "25804039", "label": "methods", "text": "Osteitis was measured in @ quadrants of each SIJ ( @-@ scores ) .", "sentence_id": 2}
+{"abstract_id": "25804039", "label": "methods", "text": "Its main criterion was considered to be a decrease in total osteitis activity ( TOA ) @ week later .", "sentence_id": 3}
+{"abstract_id": "25804039", "label": "results", "text": "In all the patients ( n = @ ) , TOA decreased from @ ( @ ; @ ) to @ ( @ ; @ ) scores ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25804039", "label": "results", "text": "In Group @ ( n = @ ) , that reduced from @ ( @ ; @ ) to @ ( @ ; @ ) scores ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "25804039", "label": "results", "text": "In Group @ ( n = @ ) , that did from @ ( @ ; @ ) to @ ( @ ; @ ) scores ( p = @ ) .", "sentence_id": 6}
+{"abstract_id": "25804039", "label": "results", "text": "At @ weeks , in in Groups @ and @ , the difference in final TOA achieved no statistical significance ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "25804039", "label": "results", "text": "In these groups , there were @ ( @ % ) and @ ( @ % ) treatment-responsive patients , respectively .", "sentence_id": 8}
+{"abstract_id": "25804039", "label": "conclusions", "text": "The intake of ET @ mg for @-weeks is associated with a reduction in the degree of ASI in patients with axSpA .", "sentence_id": 9}
+{"abstract_id": "25804039", "label": "conclusions", "text": "The use of ET @ times or more a week is more effective in diminishing osteitis than that of ET @ days or less .", "sentence_id": 10}
+{"abstract_id": "24498235", "label": "objective", "text": "To examine herpes simplex virus @ ( HSV-@ ) / HIV co-infection as a contributing factor in the increase in HIV infection among non-injecting heroin and cocaine users in New York City .", "sentence_id": 0}
+{"abstract_id": "24498235", "label": "methods", "text": "Subjects were recruited from the Beth Israel Medical Center drug detoxification and methadone maintenance programs in New York City in @-@ and @-@ .", "sentence_id": 1}
+{"abstract_id": "24498235", "label": "methods", "text": "All reported current heroin and/or cocaine use and no injection drug use .", "sentence_id": 2}
+{"abstract_id": "24498235", "label": "methods", "text": "A structured questionnaire was administered and serum samples collected for HIV and HSV-@ testing .", "sentence_id": 3}
+{"abstract_id": "24498235", "label": "methods", "text": "Population-attributable risk percentages ( PAR % s ) were estimated for associations between HSV-@ and increased susceptibility to and increased transmissibility of HIV among female NIDUs .", "sentence_id": 4}
+{"abstract_id": "24498235", "label": "results", "text": "@ subjects were recruited from @-@ , and @ subjects from @-@ .", "sentence_id": 5}
+{"abstract_id": "24498235", "label": "results", "text": "HIV prevalence increased from @ % to @ % , with nearly uniform increases among all demographic subgroups .", "sentence_id": 6}
+{"abstract_id": "24498235", "label": "results", "text": "HSV-@ / HIV co-infection was common in both time periods , with an average ( over the two time periods ) of @ % of HIV negative females infected with HSV-@ , an average of @ % of HIV negative males infected with HSV-@ ; an average of @ % of HIV positive females also infected with HSV-@ and an average of @ % of HIV positive males also infected with HSV-@ .", "sentence_id": 7}
+{"abstract_id": "24498235", "label": "results", "text": "The increase in HIV prevalence was predominantly an increase in HSV-@ / HIV co-infection , with relatively little HIV mono-infection in either time period .", "sentence_id": 8}
+{"abstract_id": "24498235", "label": "results", "text": "The estimated PAR % s indicate that approximately half of HIV acquisition among females was caused by HSV-@ infection and approximately @ % of HIV transmission from females was due to HSV-@ co-infection .", "sentence_id": 9}
+{"abstract_id": "24498235", "label": "conclusions", "text": "The increase in HIV infection among these non-injecting drug users is better considered as an increase in HSV-@ / HIV co-infection rather than simply an increase in HIV prevalence .", "sentence_id": 10}
+{"abstract_id": "24498235", "label": "conclusions", "text": "Additional interventions ( such as treatment as prevention and suppressing the effects of HSV-@ on HIV transmission ) are needed to reduce further HIV transmission from HSV-@ / HIV co-infected non-injecting drug users .", "sentence_id": 11}
+{"abstract_id": "25406780", "label": "background", "text": "Incontinence-associated dermatitis ( IAD ) is a potentially serious skin injury that can lead to pressure ulcers ( PUs ) .", "sentence_id": 0}
+{"abstract_id": "25406780", "label": "background", "text": "Multiple studies have indicated the need for evidence to find the most effective skin care protocol to reduce the incidence and severity of IAD in critically ill patients .", "sentence_id": 1}
+{"abstract_id": "25406780", "label": "objective", "text": "To compare the incidence and severity of IAD in two groups on a progressive care unit ( PCU ) using a defined skin care protocol : cleaning with a gentle cleanser and moisturizer , then applying a skin protectant/barrier .", "sentence_id": 2}
+{"abstract_id": "25406780", "label": "objective", "text": "The control group received the skin care protocol every @ hours and the interventional group received the protocol every @ hours ; both groups also received it as needed .", "sentence_id": 3}
+{"abstract_id": "25406780", "label": "methods", "text": "A @-month randomized prospective study was conducted on @ patients ( N = @ in the intervention group and N = @ in the control group ) who were incontinent of urine , stool , or both , or had a fecal diversion device or urinary catheter for more than @ days .", "sentence_id": 4}
+{"abstract_id": "25406780", "label": "results", "text": "The dermatitis score in the intervention group on discharge was significantly less ( @ % ; P @ ) in the moderate IAD group than in the control group ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25406780", "label": "results", "text": "The dermatitis score means and P values of each group were compared using a paired t test .", "sentence_id": 6}
+{"abstract_id": "25406780", "label": "conclusions", "text": "The researchers studied a defined skin care protocol using a cleanser with aloe vera and a cleansing lotion , followed by application of either a moisture barrier with silicone or skin protectant with zinc oxide and menthol , undertaken at two different frequencies .", "sentence_id": 7}
+{"abstract_id": "25406780", "label": "conclusions", "text": "Data revealed the incidence of moderate IAD was decreased in the experimental group ( receiving the skin protocol every @ hours and p.r.n. ) .", "sentence_id": 8}
+{"abstract_id": "25518180", "label": "background", "text": "Disclosing agents have a long history of use as an aid in children 's tooth brushing instruction .", "sentence_id": 0}
+{"abstract_id": "25518180", "label": "background", "text": "However , their benefit when used to improve self-performed tooth brushing ability without any tooth brushing instruction has not been investigated .", "sentence_id": 1}
+{"abstract_id": "25518180", "label": "objective", "text": "To evaluate the effect of disclosed plaque visualization on improving the self-performed , tooth brushing ability of primary school children .", "sentence_id": 2}
+{"abstract_id": "25518180", "label": "methods", "text": "A cluster-randomized , crossover study was conducted in Nakhon Nayok province , Thailand .", "sentence_id": 3}
+{"abstract_id": "25518180", "label": "methods", "text": "A total of @ second-grade schoolchildren , aged @-@ years old , from @ schools were randomly divided into @ groups .", "sentence_id": 4}
+{"abstract_id": "25518180", "label": "methods", "text": "The first group was assigned to brush with disclosed plaque visualization , while the other group brushed without disclosed plaque visualization .", "sentence_id": 5}
+{"abstract_id": "25518180", "label": "methods", "text": "One month later the groups switched procedures .", "sentence_id": 6}
+{"abstract_id": "25518180", "label": "methods", "text": "Tooth brushing ability was evaluated by the subjects ' reduction in patient hygiene performance ( PHP ) scores .", "sentence_id": 7}
+{"abstract_id": "25518180", "label": "methods", "text": "The data were analyzed using repeated-measures analysis of variance , with significance set at p < @ .", "sentence_id": 8}
+{"abstract_id": "25518180", "label": "results", "text": "Disclosed plaque visualization had a significant effect on improving the children 's self-performed , tooth brushing ability in all areas of the mouth ( p < @ ) , particularly for anterior teeth , mandibular teeth , buccal surfaces , and areas adjacent to the gingival margin ( p < @ ) .", "sentence_id": 9}
+{"abstract_id": "25518180", "label": "conclusions", "text": "Disclosed plaque visualization is a viable technique to improve children 's self-performed tooth brushing ability , and could be used in school-based oral health promotion programs .", "sentence_id": 10}
+{"abstract_id": "25236397", "label": "background", "text": "The purpose of this study was to assess the effect of Roux-en-Y gastric bypass ( RYGB ) with different pouch size in Chinese type @ diabetes mellitus ( T@DM ) patients with measured body mass index ( BMI ) @-@ kg/m ( @ ) .", "sentence_id": 0}
+{"abstract_id": "25236397", "label": "methods", "text": "In this randomized and prospective study , we evaluated the efficacy of RYGB with smaller size pouch ( @-@ ml ) versus larger pouch size ( @-@ ml ) in @ Chinese obese patients ( @ F , @ M ) with T@DM .", "sentence_id": 1}
+{"abstract_id": "25236397", "label": "methods", "text": "According to protocol , all patients were divided into two groups , smaller pouch size group and larger pouch size group , and underwent RYGB surgery .", "sentence_id": 2}
+{"abstract_id": "25236397", "label": "methods", "text": "Primary inclusion criteria of study were ( a ) a diagnosis of type @ diabetes ( glycated hemoglobin level > @ % ) , ( b ) measured BMI of at least @ kg/m ( @ ) and not yet @ kg/m ( @ ) , and ( c ) age between @ and @ years old , and ( d ) patients were excluded if they had previously undergone complex abdominal surgery or bariatric surgery .", "sentence_id": 3}
+{"abstract_id": "25236397", "label": "methods", "text": "Weight loss , BMI , percentage of excess weight loss ( % EWL ) , glycated hemoglobin , and fasting plasma glucose were obtained at @ , @ , @ , and @ months after surgery .", "sentence_id": 4}
+{"abstract_id": "25236397", "label": "results", "text": "Of these @ patients , @ ( @ % ) patients completed follow-up postoperative @ months .", "sentence_id": 5}
+{"abstract_id": "25236397", "label": "results", "text": "Weight loss and % EWL at @ months was greater in smaller pouch size group ( mean @ kg , @ % CI -@ to -@ and mean @ , @ % CI @-@ @ % ) than in larger pouch size group ( mean -@ kg , @ % CI -@ to -@ , and mean @ , @ % CI @-@ @ ) ( P = @ , P = @ , respectively ) .", "sentence_id": 6}
+{"abstract_id": "25236397", "label": "results", "text": "Glycemic control improved in both two groups , with a mean glycated hemoglobin level of @ % ( @ % CI @-@ @ % ) in smaller size group , and @ % ( @ % CI @-@ @ % ) in larger size group ( P = @ , P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25236397", "label": "results", "text": "The fasting plasma glucose level decreased significantly after surgery , with a mean level of @ mmol/L ( @ % CI @-@ @ mmol/L ) and @ mmol/L ( @ % CI @-@ @ mmol/L ) respectively , ( P = @ , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25236397", "label": "conclusions", "text": "In this short-term study , in Chinese T@DM patients with BMI @-@ kg/m ( @ ) , we observed a greater efficiency on weight loss and glycemic control with smaller pouch size compared to larger pouch size .", "sentence_id": 9}
+{"abstract_id": "25236397", "label": "conclusions", "text": "In the future , long-term follow-up and large sample study will be necessary to confirm these outcomes .", "sentence_id": 10}
+{"abstract_id": "25554995", "label": "background", "text": "Depression commonly co-occurs with alcohol use disorders but predictors of depression treatment outcome in patients with both conditions are not well established .", "sentence_id": 0}
+{"abstract_id": "25554995", "label": "methods", "text": "Outpatients with alcohol dependence and major depression ( n = @ ) were prescribed naltrexone and randomized to citalopram or placebo for @ weeks , followed by a @-week naturalistic outcome phase .", "sentence_id": 1}
+{"abstract_id": "25554995", "label": "methods", "text": "General linear mixed models examined predictors of Montgomery Asberg Depression Rating Scale ( MADRS ) score over @ weeks .", "sentence_id": 2}
+{"abstract_id": "25554995", "label": "methods", "text": "Predictors included whether depression was independent or substance-induced , and demographic , alcohol use , and personality variables ( Temperament and Character Inventory subscales ) .", "sentence_id": 3}
+{"abstract_id": "25554995", "label": "results", "text": "Most improvement in drinking and depression occurred between baseline and week @ .", "sentence_id": 4}
+{"abstract_id": "25554995", "label": "results", "text": "During follow-up , patients with substance-induced depression reduced their drinking more and they had better depression outcomes than those with independent depression .", "sentence_id": 5}
+{"abstract_id": "25554995", "label": "results", "text": "However , greater reduction in drinking was associated with better depression outcomes for both independent and substance-induced groups , while antidepressant therapy had no effect for either group .", "sentence_id": 6}
+{"abstract_id": "25554995", "label": "results", "text": "Baseline demographic and alcohol use variables did not predict depression outcomes .", "sentence_id": 7}
+{"abstract_id": "25554995", "label": "results", "text": "Among personality variables , high self-directedness was a strong predictor of better depression outcomes .", "sentence_id": 8}
+{"abstract_id": "25554995", "label": "conclusions", "text": "Subjects were not abstinent at baseline .", "sentence_id": 9}
+{"abstract_id": "25554995", "label": "conclusions", "text": "The influence of naltrexone on depression outcomes could not be tested .", "sentence_id": 10}
+{"abstract_id": "25554995", "label": "conclusions", "text": "Alcohol dependent patients with substance-induced depression have better short term depression outcomes than those with independent depression , but this is largely because they reduce their drinking more during treatment .", "sentence_id": 11}
+{"abstract_id": "24220044", "label": "objective", "text": "To evaluate the effects of training in methods of preventing childhood obesity on self-efficacy ( SE ) in nurses .", "sentence_id": 0}
+{"abstract_id": "24220044", "label": "methods", "text": "In a randomized , controlled trial conducted in child health services in Sweden , nurses in the intervention and control groups of the PRIMROSE prevention trial of childhood obesity were offered a @-day workshop on dietary and physical activity interventions , and motivational interviewing .", "sentence_id": 1}
+{"abstract_id": "24220044", "label": "methods", "text": "Self-efficacy for influencing parents to promote healthy dietary and physical activity behaviors in their children was measured using an @-item instrument .", "sentence_id": 2}
+{"abstract_id": "24220044", "label": "methods", "text": "Difference in SE between groups at post-assessment was analyzed using multiple linear regression analysis .", "sentence_id": 3}
+{"abstract_id": "24220044", "label": "results", "text": "Compared to control nurses ( n = @ ) , intervention nurses ( n = @ ) demonstrated higher SE ( = @ , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24220044", "label": "conclusions", "text": "Training in methods of preventing childhood obesity increased SE in nurses .", "sentence_id": 5}
+{"abstract_id": "24220044", "label": "conclusions", "text": "Self-efficacy should be included as a construct in evaluations of clinical training .", "sentence_id": 6}
+{"abstract_id": "25466402", "label": "objective", "text": "To determine the prevalence and predictors of sexual dysfunction ( SD ) in Parkinson 's disease ( PD ) patients .", "sentence_id": 0}
+{"abstract_id": "25466402", "label": "background", "text": "Assessments of SD in the professional literature is limited .", "sentence_id": 1}
+{"abstract_id": "25466402", "label": "background", "text": "Understanding the predictors of SD can help physicians focus on this problem in vulnerable patients .", "sentence_id": 2}
+{"abstract_id": "25466402", "label": "methods", "text": "A total of @ PD patients and @ controls answered the Arizona Sexual Experiences Scale-Thai Version ( ASEX-Thai ) and the Hamilton Depression Rating Scale ( HAMD ) questionnaires , and were asked on @ additional sets of questions about premature ejaculation ( PE ) , dyspareunia , and hypersexual disorders .", "sentence_id": 3}
+{"abstract_id": "25466402", "label": "results", "text": "The prevalence of SD in PD patients and controls was @ % and @ % respectively ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "25466402", "label": "results", "text": "PD patients had lower BMI , lower uric acid level , higher HAMD score and had sexual intercourse ( SI ) less frequently .", "sentence_id": 5}
+{"abstract_id": "25466402", "label": "results", "text": "SD correlated with greater disease severity and depression .", "sentence_id": 6}
+{"abstract_id": "25466402", "label": "results", "text": "The most distressing problem in male patients was PE ( @ % ) and orgasmic dissatisfaction ( @ % ) for female patients .", "sentence_id": 7}
+{"abstract_id": "25466402", "label": "results", "text": "Logistic regression analysis found @ factors were related to SD : no SI in the past month ( p < @ ) , postural instability ( PI ) ( p = @ ) , and HAMD item @ ( p = @ ) , predicting SD with the OR of @ , @ , and @ respectively .", "sentence_id": 8}
+{"abstract_id": "25466402", "label": "conclusions", "text": "SD in PD is common and usually occurs with depression .", "sentence_id": 9}
+{"abstract_id": "25466402", "label": "conclusions", "text": "Absence of SI in the past month , PI , and loss of libido are predictors of SD in PD .", "sentence_id": 10}
+{"abstract_id": "25466402", "label": "conclusions", "text": "A simple and quick screening of SD can be routinely performed by inquiring patients about the frequency of SI and the examination of the pull test .", "sentence_id": 11}
+{"abstract_id": "25466402", "label": "conclusions", "text": "Detailed assessment of sexual functioning and depression may guide physicians in proper management .", "sentence_id": 12}
+{"abstract_id": "24875810", "label": "background", "text": "The aim of this study was to evaluate the efficacy of buttressed stapling using a stapler with an attached polyglycolic acid sheet in reducing the rate of air leak associated with pulmonary lobectomy .", "sentence_id": 0}
+{"abstract_id": "24875810", "label": "background", "text": "Materials and", "sentence_id": 1}
+{"abstract_id": "24875810", "label": "methods", "text": "A prospective , randomized , phase III study was conducted to confirm the superiority of a buttressed stapler in a test treatment group to a conventional nonbuttressed stapler in a current international standard of care group among patients undergoing pulmonary lobectomy .", "sentence_id": 2}
+{"abstract_id": "24875810", "label": "methods", "text": "The primary end point was the frequency of intraoperative air leaks .", "sentence_id": 3}
+{"abstract_id": "24875810", "label": "results", "text": "Although no fatal postoperative bleeding occurred in the present study , this trial closed early with @ patients because the manufacturer recalled the buttressed stapler based on reports of @ serious injuries and @ fatalities following pulmonary resection in routine clinical practice .", "sentence_id": 4}
+{"abstract_id": "24875810", "label": "results", "text": "A total of @ patients treated with a stapler ( @ in the non-B group and @ in the B group ) were included as subjects in the analysis .", "sentence_id": 5}
+{"abstract_id": "24875810", "label": "results", "text": "No statistical differences were observed between the groups in the frequency of intraoperative air leaks ( @ -LSB- @ % -RSB- vs. @ -LSB- @ % -RSB- ) or the postoperative duration of air leaks ( mean : @ vs. @ days ) .", "sentence_id": 6}
+{"abstract_id": "24875810", "label": "results", "text": "The frequency of air leak from stapler holes was significantly lower in the B group than in the non-B group ( @ % -LSB- @/@ -RSB- vs. @ % -LSB- @/@ -RSB- ; p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24875810", "label": "conclusions", "text": "The efficacy of buttressed stapling in reducing the rate of air leak in patients undergoing pulmonary lobectomy could not be clearly demonstrated .", "sentence_id": 8}
+{"abstract_id": "24875810", "label": "conclusions", "text": "However , air leak from stapler holes can be prevented with buttressed stapling .", "sentence_id": 9}
+{"abstract_id": "24931587", "label": "objective", "text": "To assess the effect of acetazolamide ( Az ) on exercise performance during early acclimatization to altitude .", "sentence_id": 0}
+{"abstract_id": "24931587", "label": "methods", "text": "Az ( @ mg twice daily ) or placebo was administered for @ days in a double-blind , randomized manner followed by a rapid ascent to @ m in the Italian Alps .", "sentence_id": 1}
+{"abstract_id": "24931587", "label": "methods", "text": "Twenty healthy adults ( age range , @-@ years ) were tested at @ % of sea-level peak power output for @ minutes on a bicycle ergometer after @ to @ hours of altitude exposure .", "sentence_id": 2}
+{"abstract_id": "24931587", "label": "methods", "text": "Exercise performance was measured in relation to peripheral oxygen saturations measured from pulse oximetry ( Spo@ ) , Lake Louise acute mountain sickness ( AMS ) score , and perceived difficulty .", "sentence_id": 3}
+{"abstract_id": "24931587", "label": "results", "text": "At altitude , resting Spo@ was higher in the Az group compared with placebo ( P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24931587", "label": "results", "text": "The highest AMS scores were in @ of the placebo individuals with the lowest resting Spo@ ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24931587", "label": "results", "text": "During the exercise test , Spo@ fell in all but @ subject ( P < @ ) and was reduced more in the Az group ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24931587", "label": "results", "text": "Four Az and @ placebo subject were unable to complete the exercise test ; @ of these @ had the largest fall in Spo@ .", "sentence_id": 7}
+{"abstract_id": "24931587", "label": "results", "text": "The perception of exercise difficulty was higher in the Az subjects compared with those taking the placebo ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "24931587", "label": "results", "text": "There was an age relationship with exercise limitation ; @ of the @ older than @ years failed to complete the test whereas only @ of @ younger than @ years failed , and there were no failures in the @ younger than @ years ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24931587", "label": "conclusions", "text": "In this study group , and despite higher resting Spo@ , Az may have compromised exercise at @ m altitude during early acclimatization , particularly in older subjects .", "sentence_id": 10}
+{"abstract_id": "24411004", "label": "background", "text": "X-ray mammography remains the predominant test for screening for breast cancer , with the aim of reducing breast cancer mortality .", "sentence_id": 0}
+{"abstract_id": "24411004", "label": "background", "text": "In the English NHS Breast Screening Programme each woman 's mammograms are examined separately by two expert readers .", "sentence_id": 1}
+{"abstract_id": "24411004", "label": "background", "text": "The two readers read each batch in the same order and each indicates if there should be recall for further tests .", "sentence_id": 2}
+{"abstract_id": "24411004", "label": "background", "text": "This is a highly skilled , pressurised , repetitive and frequently intellectually unchallenging activity where readers examine one or more batches of @-@ women 's mammograms in each session .", "sentence_id": 3}
+{"abstract_id": "24411004", "label": "background", "text": "A vigilance decrement or performance decrease over time has been observed in similar repetitive visual tasks such as radar operation .", "sentence_id": 4}
+{"abstract_id": "24411004", "label": "methods", "text": "The CO-OPS study is a pragmatic , multi-centre , two-arm , double blind cluster randomised controlled trial of a computer software intervention designed to reduce the effects of a vigilance decrement in breast cancer screening .", "sentence_id": 5}
+{"abstract_id": "24411004", "label": "methods", "text": "The unit of randomisation is the batch .", "sentence_id": 6}
+{"abstract_id": "24411004", "label": "methods", "text": "Intervention batches will be examined in the opposite order by the two readers ( one forwards , one backwards ) .", "sentence_id": 7}
+{"abstract_id": "24411004", "label": "methods", "text": "Control batches will be read in the same order as one another , as is current standard practice .", "sentence_id": 8}
+{"abstract_id": "24411004", "label": "methods", "text": "The hypothesis is that cancer detection rates will be higher in the intervention group because each readers ' peak performance will occur when examining different women 's mammograms .", "sentence_id": 9}
+{"abstract_id": "24411004", "label": "methods", "text": "The trial will take place in @ English breast screening centres for @ year and @ months .", "sentence_id": 10}
+{"abstract_id": "24411004", "label": "methods", "text": "The primary outcome is cancer detection rate , which will be extracted from computer records after @ year of the trial .", "sentence_id": 11}
+{"abstract_id": "24411004", "label": "methods", "text": "The secondary outcomes include rate of disagreement between readers ( a more statistically powerful surrogate for cancer detection rate ) , recall rate , positive predictive value , and interval cancer rate ( cancers found between screening rounds which will be measured three years after the end of the trial ) .", "sentence_id": 12}
+{"abstract_id": "24411004", "label": "conclusions", "text": "This is the first trial of an intervention to ameliorate a vigilance decrement in breast cancer screening .", "sentence_id": 13}
+{"abstract_id": "24450471", "label": "background", "text": "According to the American Diabetes Association ( ADA ) , the nutritional goals for patients with type @ diabetes ( T@D ) are to achieve an optimal nutrient intake to achieve normoglycemia and a cardioprotective lipid profile .", "sentence_id": 0}
+{"abstract_id": "24450471", "label": "background", "text": "Peanuts are nutrient dense foods that contain high levels of monounsaturated fat ( MUFA ) and are a natural source of arginine , fiber , phytosterols , resveritrol , niacin , folate , vitamin E and magnesium , which have the potential for improving blood lipids and glycemic control .", "sentence_id": 1}
+{"abstract_id": "24450471", "label": "background", "text": "This study sought to evaluate the effect of a peanut enriched ADA meal plan on the nutrient profile of the total diet and cardiometabolic parameters in adults with T@D .", "sentence_id": 2}
+{"abstract_id": "24450471", "label": "methods", "text": "This was a randomized , prospective @-week parallel-group clinical trial with @ adults with T@D -LSB- age range @-@years ; body mass index ( BMI ) range @-@ @ kg/m@ -RSB- .", "sentence_id": 3}
+{"abstract_id": "24450471", "label": "methods", "text": "Subjects consumed an ADA meal plan containing ~ @ % of energy from peanuts ( peanut group ) or a peanut-free ADA meal plan ( control group ) .", "sentence_id": 4}
+{"abstract_id": "24450471", "label": "methods", "text": "Weight , BMI , waist circumference ( WC ) and nutrient intake from @-hour recalls were measured every @ weeks and fasting blood glucose ( FBG ) , HbA@c and blood lipids were measured every @ weeks .", "sentence_id": 5}
+{"abstract_id": "24450471", "label": "methods", "text": "A mixed-model repeated-measures analysis of covariance was performed to assess the significance of changes in the cardiometabolic parameters .", "sentence_id": 6}
+{"abstract_id": "24450471", "label": "results", "text": "A higher polyunsaturated fat ( PUFA ) to saturated fat diet ratio and higher intake of MUFA , PUFA , - tocopherol , niacin and magnesium was observed in the peanut group as compared to the control group ( P < @-P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24450471", "label": "results", "text": "Both groups experienced mild reductions in weight , BMI , and WC during the study ( P = @-P = @ ) , however there were no differences between the two groups in these measurements or in FBG , HbA@c or blood lipids .", "sentence_id": 8}
+{"abstract_id": "24450471", "label": "results", "text": "For each kilogram of weight loss in the entire cohort there were associations for reductions in WC of @ cm ( P < @ ) , FBG of @ mmol/l ( P = @ ) and HbA@c of @ % ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "24450471", "label": "conclusions", "text": "Daily consumption of a peanut enriched ( @g/d ) ADA meal plan over @ weeks improves the nutrient profile of the total diet and is compatible with weight management and improvement in specific blood lipids .", "sentence_id": 10}
+{"abstract_id": "24381187", "label": "background", "text": "We tested the association between pulmonary dead-space fraction ( ratio of dead space to tidal volume -LSB- V ( D ) / V ( T ) -RSB- ) and mortality in subjects with ARDS ( Berlin definition , P ( aO@ ) / F ( IO@ ) @ mm Hg ; PEEP @ cm H@O ) enrolled into a clinical trial incorporating lung-protective ventilation .", "sentence_id": 0}
+{"abstract_id": "24381187", "label": "methods", "text": "We conducted a prospective , multi-center study at medical-surgical ICUs in the United States .", "sentence_id": 1}
+{"abstract_id": "24381187", "label": "methods", "text": "A total of @ ALI subjects with acute lung injury were enrolled into a phase @ randomized , placebo-controlled study of aerosolized albuterol .", "sentence_id": 2}
+{"abstract_id": "24381187", "label": "methods", "text": "V ( D ) / V ( T ) and pulmonary mechanics were measured within @ h of enrollment and repeated daily on study days @ and @ in subjects requiring arterial blood gases for clinical management .", "sentence_id": 3}
+{"abstract_id": "24381187", "label": "results", "text": "At baseline , non-survivors had a trend toward higher V ( D ) / V ( T ) compared with survivors ( @ @ vs @ @ , respectively , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24381187", "label": "results", "text": "Differences in V ( D ) / V ( T ) between non-survivors and survivors became significant on study days @ ( @ @ vs @ @ , respectively , P = @ ) and @ ( @ @ vs @ @ , respectively , P = @ ) .", "sentence_id": 5}
+{"abstract_id": "24381187", "label": "results", "text": "Likewise , the association between VD/VT and mortality was significant on study day @ ( odds ratio per @ change in V ( D ) / V ( T ) -LSB- @ % CI -RSB- : @ -LSB- @-@ @ -RSB- P = @ ; and study day @ : @ -LSB- @-@ @ -RSB- P = @ ) after adjusting for V ( D ) / V ( T ) , P ( aO@ ) / F ( IO@ ) , oxygenation index , vasopressor use , and the primary risk for ARDS .", "sentence_id": 6}
+{"abstract_id": "24381187", "label": "results", "text": "Using a Cox proportional hazard model , V ( D ) / V ( T ) was associated with a trend toward higher mortality ( HR = @ -LSB- CI @-@ @ -RSB- , P = @ ) that became significant when the analysis was adjusted for daily oxygenation index ( HR = @ -LSB- @ % CI @-@ @ -RSB- P = @ ) .", "sentence_id": 7}
+{"abstract_id": "24381187", "label": "conclusions", "text": "Markedly elevated V ( D ) / V ( T ) ( @ ) in early ARDS is associated with higher mortality .", "sentence_id": 8}
+{"abstract_id": "24381187", "label": "conclusions", "text": "Measuring V ( D ) / V ( T ) may be useful in identifying ARDS patients at increased risk of death who are enrolled into a therapeutic trial .", "sentence_id": 9}
+{"abstract_id": "25391865", "label": "objective", "text": "To evaluate image quality of low-voltage coronary artery computed tomographic ( CT ) angiography with low contrast agent in comparison with image quality .", "sentence_id": 0}
+{"abstract_id": "25391865", "label": "methods", "text": "Forty-five patients underwent coronary artery computed tomographic ( CT ) angiography .", "sentence_id": 1}
+{"abstract_id": "25391865", "label": "methods", "text": "They were randomly assigned to @ groups , group A ( n = @ ) were scanned in @ kVp with @ mgI/ml iodinated contrast agent mode , group B ( n = @ ) were scanned in @ kVp with @ mgI/ml iodinated contrast agent mode , group C ( n = @ ) were scanned in @ kVp with @ mgI/ml iodinated contrast agent mode .", "sentence_id": 2}
+{"abstract_id": "25391865", "label": "methods", "text": "Then measured CT attenuation value of three main branches ( RCA , LAD and CX ) of coronary artery , And compare the SNR , CNR , the effective radiation dose ( ED ) and iodine intake .", "sentence_id": 3}
+{"abstract_id": "25391865", "label": "methods", "text": "The Kappa test were used to quantify inter - and intra-reader agreement in detecting quality of the images under different scanning solutions .", "sentence_id": 4}
+{"abstract_id": "25391865", "label": "results", "text": "Three groups of coronary artery CT image quality was no statistically significant differences ( all P values > @ ) , Good inter - and intra-reader agreement ( k = @ , P < @ ) for the detection of noise in all the patients .", "sentence_id": 5}
+{"abstract_id": "25391865", "label": "results", "text": "There was significant difference in the CT attenuation of RCA , LAD and CX among the @ groups ( P < @ ) , the CT attenuation was the highest in group B , the CT value of RCA , LAD and CX were @ @ , @ @ , @ @ HU , respectively.the CT attenuation was the lowest in group C , the CT value of RCA , LAD and CX were @ @ , @ @ , @ @ HU , respectively .", "sentence_id": 6}
+{"abstract_id": "25391865", "label": "results", "text": "There was no significant difference in the SNR and CNR among the @ groups ( P > @ ) .", "sentence_id": 7}
+{"abstract_id": "25391865", "label": "results", "text": "There was significant difference in the ED among the @ groups ( P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25391865", "label": "results", "text": "The ED value of the group A was bigger than the value of the group B and C.", "sentence_id": 9}
+{"abstract_id": "25391865", "label": "results", "text": "There was no significant difference between the group B and C. Compared the group A and B , the iodine intake of the group C had fallen by @ % .", "sentence_id": 10}
+{"abstract_id": "25391865", "label": "conclusions", "text": "The coronary artery CT angiography using @ kVp with @ mgI/ml iodinated contrast agent provide similar objective or subjective image quality compared with the ( @ mgI/ml ) and the @ kVp ( @ mgI/ml ) , thus enabling effective dose and iodine intake reduction without loss of diagnostic information .", "sentence_id": 11}
+{"abstract_id": "24439462", "label": "objective", "text": "To determine precisely the mean change in refractive power induced by treatment in patients with diabetic macular edema ( DME ) .", "sentence_id": 0}
+{"abstract_id": "24439462", "label": "methods", "text": "Prospective , randomized study .", "sentence_id": 1}
+{"abstract_id": "24439462", "label": "methods", "text": "Fifty eyes of @ consecutive patients with clinically significant macular edema receiving all @ types of current state-of-the-art treatment with intravitreal antiedematous substances ( ranibizumab , bevacizumab , or triamcinolone ) .", "sentence_id": 2}
+{"abstract_id": "24439462", "label": "methods", "text": "Patients were followed up at monthly intervals and were treated following a standardized pro re nata regimen according to protocol .", "sentence_id": 3}
+{"abstract_id": "24439462", "label": "methods", "text": "Best-corrected visual acuity ( BCVA ) was determined by certified visual acuity examiners .", "sentence_id": 4}
+{"abstract_id": "24439462", "label": "methods", "text": "The refractive power of the treated eyes was determined using a push-plus technique .", "sentence_id": 5}
+{"abstract_id": "24439462", "label": "methods", "text": "The change in refraction between baseline and the visit when the macula was completely dry or when the central subfield thickness ( CST ) measured by optical coherence tomography had reached the thinnest level was analyzed .", "sentence_id": 6}
+{"abstract_id": "24439462", "label": "methods", "text": "Spherical equivalent refraction ( SER ) and CST .", "sentence_id": 7}
+{"abstract_id": "24439462", "label": "results", "text": "Fifty eyes of @ patients received intravitreal therapy using ranibizumab ( n = @ ) , bevacizumab ( n = @ ) , or triamcinolone ( n = @ ) .", "sentence_id": 8}
+{"abstract_id": "24439462", "label": "results", "text": "Mean BCVA was @ logarithm of the minimum angle of resolution ( logMAR ) and mean CST was @ m.", "sentence_id": 9}
+{"abstract_id": "24439462", "label": "results", "text": "The mean SER was @ diopters ( D ) at baseline .", "sentence_id": 10}
+{"abstract_id": "24439462", "label": "results", "text": "The BCVA at the time of optimal retinal morphologic features was @ logMAR , mean CST was @ m , and mean change in SER was -@ D. Changes is BCVA and CST were statistically significant ( P < @ ) , but the SER change was not ( P = @ ) .", "sentence_id": 11}
+{"abstract_id": "24439462", "label": "conclusions", "text": "Appropriate spectacle correction can be prescribed to patients with DME any time during ongoing therapy using antiedematous substances because resolution of retinal thickening is not associated with an increased risk of a myopic shift .", "sentence_id": 12}
+{"abstract_id": "24814973", "label": "objective", "text": "High-frequency oscillation combined with tracheal gas insufflation ( HFO-TGI ) improves oxygenation in patients with acute respiratory distress syndrome ( ARDS ) .", "sentence_id": 0}
+{"abstract_id": "24814973", "label": "objective", "text": "There are limited physiologic data regarding the effects of HFO-TGI on hemodynamics and pulmonary edema during ARDS .", "sentence_id": 1}
+{"abstract_id": "24814973", "label": "objective", "text": "The aim of this study was to investigate the effect of HFO-TGI on extravascular lung water ( EVLW ) .", "sentence_id": 2}
+{"abstract_id": "24814973", "label": "methods", "text": "We conducted a prospective , randomized , crossover study .", "sentence_id": 3}
+{"abstract_id": "24814973", "label": "methods", "text": "Consecutive eligible patients with ARDS received sessions of conventional mechanical ventilation with recruitment maneuvers ( RMs ) , followed by HFO-TGI with RMs , or vice versa .", "sentence_id": 4}
+{"abstract_id": "24814973", "label": "methods", "text": "Each ventilatory technique was administered for @ hours .", "sentence_id": 5}
+{"abstract_id": "24814973", "label": "methods", "text": "The order of administration was randomly assigned .", "sentence_id": 6}
+{"abstract_id": "24814973", "label": "methods", "text": "Arterial/central venous blood gas analysis and measurement of hemodynamic parameters and EVLW were performed at baseline and after each @-hour period using the single-indicator thermodilution technique .", "sentence_id": 7}
+{"abstract_id": "24814973", "label": "results", "text": "Twelve patients received @ sessions .", "sentence_id": 8}
+{"abstract_id": "24814973", "label": "results", "text": "Pao@/fraction of inspired oxygen and respiratory system compliance were higher ( P < @ for both ) , whereas extravascular lung water index to predicted body weight and oxygenation index were lower ( P = @ and @ , respectively ) in HFO-TGI compared with conventional mechanical ventilation .", "sentence_id": 9}
+{"abstract_id": "24814973", "label": "results", "text": "There was a significant correlation between Pao@/fraction of inspired oxygen improvement and extravascular lung water index drop during HFO-TGI ( Rs = -@ , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "24814973", "label": "conclusions", "text": "High-frequency oscillation combined with tracheal gas insufflation improves gas exchange and lung mechanics in ARDS and potentially attenuates EVLW accumulation .", "sentence_id": 11}
+{"abstract_id": "25597563", "label": "objective", "text": "To examine the association between blood pressure ( BP ) measures and symptoms of apathy and depression in older adults with various levels of functional ability .", "sentence_id": 0}
+{"abstract_id": "25597563", "label": "methods", "text": "Cross-sectional study using baseline data from the Discontinuation of Antihypertensive Treatment in Elderly people ( DANTE ) Study Leiden .", "sentence_id": 1}
+{"abstract_id": "25597563", "label": "methods", "text": "Primary care setting , the Netherlands .", "sentence_id": 2}
+{"abstract_id": "25597563", "label": "methods", "text": "Community-dwelling individuals aged @ and older ( N = @ ) .", "sentence_id": 3}
+{"abstract_id": "25597563", "label": "methods", "text": "Systolic BP ( SBP ) , diastolic BP ( DBP ) , and mean arterial pressure ( MAP ) were measured during home visits .", "sentence_id": 4}
+{"abstract_id": "25597563", "label": "methods", "text": "Symptoms of apathy and depression were assessed using the Apathy Scale and the Geriatric Depression Scale ( GDS-@ ) , respectively .", "sentence_id": 5}
+{"abstract_id": "25597563", "label": "methods", "text": "Stratified linear regression was performed in participants with better and worse functional ability according to the median of the Groningen Activity Restriction Scale .", "sentence_id": 6}
+{"abstract_id": "25597563", "label": "results", "text": "In participants with lower functional ability , each @-mmHg lower SBP , DBP , and MAP was associated with higher Apathy Scale scores ( @ , @ , and @ points , respectively , all P < @ ) but not with GDS-@ scores .", "sentence_id": 7}
+{"abstract_id": "25597563", "label": "results", "text": "In participants with higher functional ability , BP measures were not associated with Apathy Scale or GDS-@ scores .", "sentence_id": 8}
+{"abstract_id": "25597563", "label": "conclusions", "text": "In older participants with poorer functional ability , lower BP was associated with more symptoms of apathy but not depression .", "sentence_id": 9}
+{"abstract_id": "24463662", "label": "objective", "text": "To examine the association between second-trimester maternal serum @-hydroxyvitamin D concentrations and risk of small for gestational age ( SGA ) in singleton live births .", "sentence_id": 0}
+{"abstract_id": "24463662", "label": "methods", "text": "We assayed serum samples at @-@ weeks of gestation for @-hydroxyvitamin D in a sample of participants in a multicenter clinical trial of low-dose aspirin for the prevention of preeclampsia in high-risk women ( n = @ ) .", "sentence_id": 1}
+{"abstract_id": "24463662", "label": "methods", "text": "Multivariable log-binomial regression models were used to assess the association between @-hydroxyvitamin D and risk of SGA ( birth weight less than the @ percentile for gestational age ) after adjustment for confounders including maternal prepregnancy obesity , race , treatment allocation , and risk group .", "sentence_id": 2}
+{"abstract_id": "24463662", "label": "results", "text": "Thirteen percent of neonates were SGA at birth .", "sentence_id": 3}
+{"abstract_id": "24463662", "label": "results", "text": "Mean ( standard deviation ) @-hydroxyvitamin D concentrations were lower in women who delivered SGA ( @ -LSB- @ -RSB- nmol/L ) compared with non-SGA neonates ( @ -LSB- @ -RSB- nmol/L , P = @ ) .", "sentence_id": 4}
+{"abstract_id": "24463662", "label": "results", "text": "In adjusted models , @-hydroxyvitamin D concentrations of @-@ nmol/L and @ nmol/L or greater compared with less than @ nmol/L were associated with @ % ( @ % confidence interval -LSB- CI -RSB- @-@ @ ) and @ % ( @ % CI @-@ @ ) reductions in risk of SGA , respectively .", "sentence_id": 5}
+{"abstract_id": "24463662", "label": "results", "text": "Race and maternal obesity each modified this association .", "sentence_id": 6}
+{"abstract_id": "24463662", "label": "results", "text": "White women with @-hydroxyvitamin D @ nmol/L or greater compared with less than @ nmol/L had a @ % reduction in SGA risk ( adjusted risk ratio @ , @ % CI @-@ @ ) and nonobese women with @-hydroxyvitamin D @ nmol/L or greater compared with less than @ nmol/L had a @ % reduction in SGA risk ( adjusted risk ratio @ , @ % CI @-@ @ ) .", "sentence_id": 7}
+{"abstract_id": "24463662", "label": "results", "text": "There was no association between @-hydroxyvitamin D and risk of SGA in black or obese mothers .", "sentence_id": 8}
+{"abstract_id": "24463662", "label": "conclusions", "text": "Maternal vitamin D status in the second trimester is associated with risk of SGA among all women and in the subgroups of white and nonobese women .", "sentence_id": 9}
+{"abstract_id": "24831970", "label": "background", "text": "Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants", "sentence_id": 0}
+{"abstract_id": "24831970", "label": "objective", "text": "The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants .", "sentence_id": 1}
+{"abstract_id": "24831970", "label": "methods", "text": "A randomized interventional study was designed comparing infants in the NICU of Hospital Juarez de Mxico , exposed from birth either to an LD environment ( LD , n = @ ) or to the traditional continuous light ( LL , n = @ ) .", "sentence_id": 2}
+{"abstract_id": "24831970", "label": "methods", "text": "The LD condition was achieved by placing individual removable helmets over the infant 's heads .", "sentence_id": 3}
+{"abstract_id": "24831970", "label": "methods", "text": "Body weight gain was analyzed , as the main indicator of stability and the main criteria for discharge in preterm infants born at @ week gestational age .", "sentence_id": 4}
+{"abstract_id": "24831970", "label": "results", "text": "Infants maintained in an LD cycle gained weight faster than infants in LL and therefore attained a shorter hospital stay , ( @ vs @ days ; P > @ ) .", "sentence_id": 5}
+{"abstract_id": "24831970", "label": "results", "text": "Also , LD infants exhibited improved oxygen saturation and developed a daily melatonin rhythm .", "sentence_id": 6}
+{"abstract_id": "24831970", "label": "conclusions", "text": "These findings provide a convenient alternative for establishing an LD environment for preterm healthy newborns in the NICU and confirm the beneficial effects of an alternating LD cycle for growth and weight gain and for earlier discharge time .", "sentence_id": 7}
+{"abstract_id": "24831970", "label": "conclusions", "text": "Here we provide an easy and practical alternative to implement light/dark conditions in the NICU .", "sentence_id": 8}
+{"abstract_id": "25475358", "label": "objective", "text": "Over-the-counter combinations containing acetaminophen and phenylephrine for treatment of the common cold and influenza are widespread , but there are few data about pharmacokinetics of these two drugs used in combination .", "sentence_id": 0}
+{"abstract_id": "25475358", "label": "objective", "text": "We aimed to investigate pharmacokinetic interactions between acetaminophen and phenylephrine .", "sentence_id": 1}
+{"abstract_id": "25475358", "label": "methods", "text": "A series of four randomised , open-label , crossover studies investigating phenylephrine and acetaminophen combination pharmacokinetics were undertaken ( n = @ , @ , @ and @ ) using standard non-compartmental analyses .", "sentence_id": 2}
+{"abstract_id": "25475358", "label": "methods", "text": "Time-concentration observations from these four studies were pooled to examine the interaction between these two compounds .", "sentence_id": 3}
+{"abstract_id": "25475358", "label": "methods", "text": "Data were analysed using non-linear mixed effects models .", "sentence_id": 4}
+{"abstract_id": "25475358", "label": "results", "text": "Non-compartmental analyses showed an approximate doubling of phenylephrine plasma concentration when the standard @-mg dose was administered in combination with acetaminophen .", "sentence_id": 5}
+{"abstract_id": "25475358", "label": "results", "text": "Population analysis was based on data from @ subjects with @ observations .", "sentence_id": 6}
+{"abstract_id": "25475358", "label": "results", "text": "The relative bioavailability of phenylephrine @ mg was doubled ( Fbio @ , @ % CI @ , @ ) when combined with acetaminophen @ mg , while the absorption half-time was reduced by @ % .", "sentence_id": 7}
+{"abstract_id": "25475358", "label": "results", "text": "When combined with @ mg of acetaminophen , bioavailability increased by @ % ( Fbio @ ) .", "sentence_id": 8}
+{"abstract_id": "25475358", "label": "results", "text": "Phenylephrine @ mg in combination with acetaminophen @ mg produced a phenylephrine plasma time-concentration profile similar to that seen with phenylephrine @ mg administered alone .", "sentence_id": 9}
+{"abstract_id": "25475358", "label": "conclusions", "text": "The relative bioavailability of phenylephrine was increased when co-administered with acetaminophen .", "sentence_id": 10}
+{"abstract_id": "24361097", "label": "background", "text": "The Schirmer test ( ST ) evaluates the volume of tears in potential dry eye candidates via a strip placed in the lower tear lake .", "sentence_id": 0}
+{"abstract_id": "24361097", "label": "background", "text": "Previously reported inconsistencies in the results may be in part due to the lack of standardization as to the methodology , e.g. the eye position during the test .", "sentence_id": 1}
+{"abstract_id": "24361097", "label": "background", "text": "The purpose of this study was to evaluate the effect of eye position on the ST score .", "sentence_id": 2}
+{"abstract_id": "24361097", "label": "methods", "text": "A ST was performed in a randomized fashion with and without anesthesia in three open eye positions ( primary , superior and inferior ) at @ from each other .", "sentence_id": 3}
+{"abstract_id": "24361097", "label": "methods", "text": "Palpebral aperture , age and a dry eye questionnaire ( OSDI ) were evaluated for correlation with the ST.", "sentence_id": 4}
+{"abstract_id": "24361097", "label": "results", "text": "In the @ non-dry eye volunteers ( n = @ , ages @-@ , mean OSDI score @ ) , the ST results were , as expected , lower overall ( p < @ ) with anesthesia ( @ @ mm ) than without ( @ @ mm ) .", "sentence_id": 5}
+{"abstract_id": "24361097", "label": "results", "text": "The inferior gaze position resulted in higher values ( p < @ ) than the other two positions , regardless of the use of anesthesia .", "sentence_id": 6}
+{"abstract_id": "24361097", "label": "results", "text": "No correlation was noted between the palpebral aperture , age , questionnaire and the ST.", "sentence_id": 7}
+{"abstract_id": "24361097", "label": "conclusions", "text": "The ST seems to be influenced by the position of gaze .", "sentence_id": 8}
+{"abstract_id": "24361097", "label": "conclusions", "text": "However , the mechanism for this , effect remains unclear .", "sentence_id": 9}
+{"abstract_id": "24361097", "label": "conclusions", "text": "Further studies could focus on whether an inferior gaze of @ compresses the tear film falsely , thereby elevating the tear volume .", "sentence_id": 10}
+{"abstract_id": "24361097", "label": "conclusions", "text": "It is recommended that the clinician should adopt a standard eye position for the ST and that future reports provide specifics as to the methodology used .", "sentence_id": 11}
+{"abstract_id": "25873721", "label": "background", "text": "To prospectively evaluate whether short-term high-intensity ( interval ) training ( HI ( I ) T ) induces detectable morphological cardiac changes in previously untrained men in cardiovascular magnetic resonance imaging .", "sentence_id": 0}
+{"abstract_id": "25873721", "label": "results", "text": "Eighty-four untrained volunteers were randomly assigned to a HI ( I ) T group ( n = @ ; @ years ) or an inactive control group ( n = @ ; @ years ) .", "sentence_id": 1}
+{"abstract_id": "25873721", "label": "results", "text": "HI ( I ) T focused on interval runs ( intensity : @ % -@ % of individually calculated heart rate at the anaerobic threshold ) .", "sentence_id": 2}
+{"abstract_id": "25873721", "label": "results", "text": "Before and after @ weeks , all subjects underwent physiological examination , stepwise treadmill test with blood lactate analysis , and contrast-enhanced cardiovascular magnetic resonance imaging ( cine , tagging , and delayed enhancement ) .", "sentence_id": 3}
+{"abstract_id": "25873721", "label": "results", "text": "Indexed left ventricular ( LV ) and right ventricular ( RV ) volume ( LV , @-@ @ ; RV , @-@ @ ) and mass ( LV , @-@ @ ; RV , @-@ @ ) significantly increased with HI ( I ) T. Changes in LV and RV morphological parameters with HI ( I ) T were highly correlated with an increase in maximal aerobic capacity ( VO@max ) and a decrease in blood lactate concentration at the anaerobic threshold .", "sentence_id": 4}
+{"abstract_id": "25873721", "label": "results", "text": "Mean LV and RV remodeling index of HI ( I ) T group did not alter with training ( @ @ and @ g/mL , respectively -LSB- P = @ and P = @ -RSB- ) , indicating balanced cardiac adaptation .", "sentence_id": 5}
+{"abstract_id": "25873721", "label": "results", "text": "Myocardial circumferential strain decreased after HI ( I ) T within all @ basal segments ( anteroseptal , P = @ and anterolateral , P < @ ) .", "sentence_id": 6}
+{"abstract_id": "25873721", "label": "results", "text": "There was no late gadolinium enhancement in any of the participants before or post HI ( I ) T.", "sentence_id": 7}
+{"abstract_id": "25873721", "label": "conclusions", "text": "Sixteen weeks of HI ( I ) T lead to measurable changes in cardiac atrial and ventricular morphology and function in previously untrained men .", "sentence_id": 8}
+{"abstract_id": "25873721", "label": "conclusions", "text": "This correlates with improvements in parameters of endurance capacity .", "sentence_id": 9}
+{"abstract_id": "25002832", "label": "background", "text": "Shoulder surgery is often performed in the beach-chair position , a position associated with arterial hypotension and subsequent risk of cerebral ischaemia .", "sentence_id": 0}
+{"abstract_id": "25002832", "label": "background", "text": "It can be performed under general anaesthesia or with an interscalene brachial plexus block , each of which has specific advantages but also specific negative effects on blood pressure control .", "sentence_id": 1}
+{"abstract_id": "25002832", "label": "background", "text": "It would be worthwhile to combine the advantages of the two , but the effects of the combination on the circulation are not well investigated .", "sentence_id": 2}
+{"abstract_id": "25002832", "label": "background", "text": "We studied blood pressure , heart rate , and incidence of adverse circulatory events in patients undergoing shoulder surgery in general anaesthesia with or without an interscalene block .", "sentence_id": 3}
+{"abstract_id": "25002832", "label": "methods", "text": "Prospective , randomised , blinded study in outpatients ( age @ to @years ) undergoing shoulder arthroscopy .", "sentence_id": 4}
+{"abstract_id": "25002832", "label": "methods", "text": "General anaesthesia was with propofol/opioid , interscalene block with @ml @ % mepivacaine .", "sentence_id": 5}
+{"abstract_id": "25002832", "label": "methods", "text": "Hypotension requiring treatment was defined as a mean arterial pressure < @mmHg or a systolic pressure < @ % of baseline ; relevant bradycardia was a heart rate < @bpm with a decrease in blood pressure .", "sentence_id": 6}
+{"abstract_id": "25002832", "label": "results", "text": "Forty-two patients had general anaesthesia alone , @ had general anaesthesia plus interscalene block .", "sentence_id": 7}
+{"abstract_id": "25002832", "label": "results", "text": "The average systolic blood pressure under anaesthesia in the beach-chair position was @ vs. @ mmHg ( p = @ ; all comparisons General vs. General-Regional ) .", "sentence_id": 8}
+{"abstract_id": "25002832", "label": "results", "text": "The incidence of a mean arterial pressure under @mmHg or a decrease in systolic pressure of more than @ % from baseline was @ % vs. @ % ( p = @ ) .", "sentence_id": 9}
+{"abstract_id": "25002832", "label": "results", "text": "The number of patients with a heart rate lower than @ and a concomitant blood pressure decrease was @ vs. @ ( p = @ ) .", "sentence_id": 10}
+{"abstract_id": "25002832", "label": "conclusions", "text": "One can safely combine interscalene block with general anaesthesia for surgery in the beach-chair position in ASA I and II patients .", "sentence_id": 11}
+{"abstract_id": "25175124", "label": "objective", "text": "No clinically effective treatment for promoting peripheral axonal regeneration has yet been established .", "sentence_id": 0}
+{"abstract_id": "25175124", "label": "objective", "text": "Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin ( MeCbl ) , an analogue of vitamin B@ , promotes axonal growth in peripheral nerve injury .", "sentence_id": 1}
+{"abstract_id": "25175124", "label": "objective", "text": "We herein assessed the safety and efficacy of an ultra-high dose MeCbl treatment for patients with peripheral neuropathy and chronic axonal degeneration .", "sentence_id": 2}
+{"abstract_id": "25175124", "label": "methods", "text": "Fourteen patients with immune-mediated or hereditary neuropathy in the chronic progressive or stable phase were enrolled .", "sentence_id": 3}
+{"abstract_id": "25175124", "label": "methods", "text": "MeCbl , @ mg/day for @ days followed by monthly @ mg for @ months , was intravenously administered .", "sentence_id": 4}
+{"abstract_id": "25175124", "label": "methods", "text": "The patients were evaluated before and @ year following treatment .", "sentence_id": 5}
+{"abstract_id": "25175124", "label": "methods", "text": "The primary endpoints were safety and improvement in the Medical Research Council ( MRC ) sum score in at least two muscles of the @ muscles .", "sentence_id": 6}
+{"abstract_id": "25175124", "label": "methods", "text": "This trial is registered with the University Hospital Medical Information Network ( UMIN ) Center in Japan under the ID : UMIN@ .", "sentence_id": 7}
+{"abstract_id": "25175124", "label": "results", "text": "There were no adverse effects in twelve of the patients , whereas treatment was discontinued in two patients who had seborrheic dermatitis at @ months and respiratory tract infection at @ months , respectively .", "sentence_id": 8}
+{"abstract_id": "25175124", "label": "results", "text": "Therefore , twelve patients were evaluated for the primary outcomes ; the MRC sum score was improved in seven of the patients and unchanged or worsened in the remaining five patients .", "sentence_id": 9}
+{"abstract_id": "25175124", "label": "conclusions", "text": "Intravenous ultra-high dose MeCbl treatment is a safe and potentially efficacious therapy for patients with peripheral neuropathy and chronic axonal degeneration .", "sentence_id": 10}
+{"abstract_id": "24612471", "label": "objective", "text": "To validate robot-assisted surgery skills acquisition using an augmented reality ( AR ) - based module for urethrovesical anastomosis ( UVA ) .", "sentence_id": 0}
+{"abstract_id": "24612471", "label": "methods", "text": "Participants at three institutions were randomised to a Hands-on Surgical Training ( HoST ) technology group or a control group .", "sentence_id": 1}
+{"abstract_id": "24612471", "label": "methods", "text": "The HoST group was given procedure-based training for UVA within the haptic-enabled AR-based HoST environment .", "sentence_id": 2}
+{"abstract_id": "24612471", "label": "methods", "text": "The control group did not receive any training .", "sentence_id": 3}
+{"abstract_id": "24612471", "label": "methods", "text": "After completing the task , the control group was offered to cross over to the HoST group ( cross-over group ) .", "sentence_id": 4}
+{"abstract_id": "24612471", "label": "methods", "text": "A questionnaire administered after HoST determined the feasibility and acceptability of the technology .", "sentence_id": 5}
+{"abstract_id": "24612471", "label": "methods", "text": "Performance of UVA using an inanimate model on the daVinci Surgical System ( Intuitive Surgical Inc. , Sunnyvale , CA , USA ) was assessed using a UVA evaluation score and a Global Evaluative Assessment of Robotic Skills ( GEARS ) score .", "sentence_id": 6}
+{"abstract_id": "24612471", "label": "methods", "text": "Participants completed the National Aeronautics and Space Administration Task Load Index ( NASA TLX ) questionnaire for cognitive assessment , as outcome measures .", "sentence_id": 7}
+{"abstract_id": "24612471", "label": "methods", "text": "A Wilcoxon rank-sum test was used to compare outcomes among the groups ( HoST group vs control group and control group vs cross-over group ) .", "sentence_id": 8}
+{"abstract_id": "24612471", "label": "results", "text": "A total of @ individuals participated in the study .", "sentence_id": 9}
+{"abstract_id": "24612471", "label": "results", "text": "UVA evaluation scores showed significant differences in needle driving ( @ vs @ ; P = @ ) , needle positioning ( @ vs @ ; P = @ ) and suture placement ( @ vs @ ; P = @ ) in the HoST vs the control group .", "sentence_id": 10}
+{"abstract_id": "24612471", "label": "results", "text": "The HoST group obtained significantly higher scores ( @ vs @ ; P @ ) on the GEARS .", "sentence_id": 11}
+{"abstract_id": "24612471", "label": "results", "text": "The NASA TLX indicated lower temporal demand and effort in the HoST group ( @ vs @ ; P = @ and @ vs @ ; P = @ , respectively ) .", "sentence_id": 12}
+{"abstract_id": "24612471", "label": "results", "text": "In all , @ % of participants found that HoST was similar to the real surgical procedure , and @ % believed that HoST could improve confidence for carrying out the real intervention .", "sentence_id": 13}
+{"abstract_id": "24612471", "label": "conclusions", "text": "Training in UVA in an AR environment improves technical skill acquisition with minimal cognitive demand .", "sentence_id": 14}
+{"abstract_id": "24350814", "label": "objective", "text": "The purpose of this study was to test the efficacy of clomipramine and fluoxetine , controlled by placebo , and compare their action in children and adolescents with anxiety disorders .", "sentence_id": 0}
+{"abstract_id": "24350814", "label": "methods", "text": "Thirty subjects ( ages @-@ years ) , who were diagnosed with generalized anxiety disorder and/or separation anxiety disorder and/or social phobia , were submitted to a @ week double-blind , randomized , placebo-controlled trial of clomipramine and fluoxetine .", "sentence_id": 1}
+{"abstract_id": "24350814", "label": "methods", "text": "The instruments included : the Schedule for Affective Disorders and Schizophrenia , the Multidimensional Anxiety Scale for Children , the Children 's Depression Inventory , the Clinical Global Impressions , and the Children 's Global Assessment Scale .", "sentence_id": 2}
+{"abstract_id": "24350814", "label": "results", "text": "All groups ( clomipramine -LSB- n = @ -RSB- , fluoxetine -LSB- n = @ -RSB- , placebo -LSB- n = @ -RSB- ) showed a significant improvement after @ weeks of treatment .", "sentence_id": 3}
+{"abstract_id": "24350814", "label": "results", "text": "There were significant differences between the fluoxetine and placebo groups in some ratings of anxiety severity and impairment .", "sentence_id": 4}
+{"abstract_id": "24350814", "label": "results", "text": "No significant differences were observed between clomipramine and placebo groups or between fluoxetine and clomipramine groups .", "sentence_id": 5}
+{"abstract_id": "24350814", "label": "conclusions", "text": "Treatment with placebo showed an unusual high response rate .", "sentence_id": 6}
+{"abstract_id": "24350814", "label": "conclusions", "text": "Clomipramine showed similar efficacy compared with fluoxetine , although it was not superior to placebo .", "sentence_id": 7}
+{"abstract_id": "24763910", "label": "background", "text": "Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood .", "sentence_id": 0}
+{"abstract_id": "24763910", "label": "objective", "text": "The aim of the present study was to examine the effects of the opioid antagonist , naltrexone , on neural response to rewarding and aversive sight and taste stimuli .", "sentence_id": 1}
+{"abstract_id": "24763910", "label": "methods", "text": "We used functional magnetic resonance imaging ( fMRI ) to examine the neural responses to the sight and taste of pleasant ( chocolate ) and aversive ( mouldy strawberry ) stimuli in @ healthy volunteers who received a single oral dose of naltrexone ( @mg ) and placebo in a double-blind , repeated-measures cross-over , design .", "sentence_id": 2}
+{"abstract_id": "24763910", "label": "results", "text": "Relative to placebo , naltrexone decreased reward activation to chocolate in the dorsal anterior cingulate cortex and caudate , and increased aversive-related activation to unpleasant strawberry in the amygdala and anterior insula .", "sentence_id": 3}
+{"abstract_id": "24763910", "label": "conclusions", "text": "These findings suggest that modulation of key brain areas involved in reward processing , cognitive control and habit formation such as the dorsal anterior cingulate cortex ( dACC ) and caudate might underlie reduction in food intake with opioid antagonism .", "sentence_id": 4}
+{"abstract_id": "24763910", "label": "conclusions", "text": "Furthermore we show for the first time that naltrexone can increase activations related to aversive food stimuli .", "sentence_id": 5}
+{"abstract_id": "24763910", "label": "conclusions", "text": "These results support further investigation of opioid treatments in obesity .", "sentence_id": 6}
+{"abstract_id": "25183726", "label": "background", "text": "Disturbance of the sleep-wake cycle is a characteristic of delirium .", "sentence_id": 0}
+{"abstract_id": "25183726", "label": "background", "text": "In addition , changes in melatonin rhythm influence the circadian rhythm and are associated with delirium .", "sentence_id": 1}
+{"abstract_id": "25183726", "label": "background", "text": "We compared the effect of melatonin and placebo on the incidence and duration of delirium .", "sentence_id": 2}
+{"abstract_id": "25183726", "label": "methods", "text": "We performed this multicentre , double-blind , randomized controlled trial between November @ and May @ in @ academic and @ nonacademic hospitals .", "sentence_id": 3}
+{"abstract_id": "25183726", "label": "methods", "text": "Patients aged @ years or older who were scheduled for acute hip surgery were eligible for inclusion .", "sentence_id": 4}
+{"abstract_id": "25183726", "label": "methods", "text": "Patients received melatonin @ mg or placebo in the evening for @ consecutive days , starting within @ hours after admission .", "sentence_id": 5}
+{"abstract_id": "25183726", "label": "methods", "text": "The primary outcome was incidence of delirium within @ days of admission .", "sentence_id": 6}
+{"abstract_id": "25183726", "label": "methods", "text": "We also monitored the duration of delirium .", "sentence_id": 7}
+{"abstract_id": "25183726", "label": "results", "text": "A total of @ patients were randomly assigned to the @ study groups .", "sentence_id": 8}
+{"abstract_id": "25183726", "label": "results", "text": "We subsequently excluded @ patients for whom the primary end point could not be measured or who had delirium before the second day of the study .", "sentence_id": 9}
+{"abstract_id": "25183726", "label": "results", "text": "After these postrandomization exclusions , data for @ patients were included in the main analysis .", "sentence_id": 10}
+{"abstract_id": "25183726", "label": "results", "text": "The overall mean age was @ years , @ ( @ % ) of the patients lived at home before admission , and @ ( @ % ) had cognitive impairment .", "sentence_id": 11}
+{"abstract_id": "25183726", "label": "results", "text": "We observed no effect of melatonin on the incidence of delirium : @/@ ( @ % ) in the melatonin group v. @/@ ( @ % ) in the placebo group ; difference @ ( @ % confidence interval -@ to @ ) percentage points .", "sentence_id": 12}
+{"abstract_id": "25183726", "label": "results", "text": "There were no between-group differences in mortality or in cognitive or functional outcomes at @-month follow-up .", "sentence_id": 13}
+{"abstract_id": "25183726", "label": "conclusions", "text": "In this older population with hip fracture , treatment with melatonin did not reduce the incidence of delirium .", "sentence_id": 14}
+{"abstract_id": "25348510", "label": "background", "text": "Left ventricular hypertrophy is associated with adverse outcomes , including death , during cardiac surgery .", "sentence_id": 0}
+{"abstract_id": "25348510", "label": "background", "text": "This may be facilitated by an increased oxygen demand and diastolic dysfunction .", "sentence_id": 1}
+{"abstract_id": "25348510", "label": "background", "text": "Levosimendan augments haemodynamics without further oxygen consumption and improves echocardiographic indices of diastolic dysfunction .", "sentence_id": 2}
+{"abstract_id": "25348510", "label": "background", "text": "This study aimed to describe the haemodynamic effects of short-term pre - and intra-operative levosimendan infusion including advanced echocardiographic measures of diastolic and systolic heart function .", "sentence_id": 3}
+{"abstract_id": "25348510", "label": "methods", "text": "The study was randomised , double-blinded and placebo-controlled performed at a single-centre university hospital .", "sentence_id": 4}
+{"abstract_id": "25348510", "label": "methods", "text": "Patients with left ventricular hypertrophy and ejection fraction > @ % scheduled for single procedure aortic valve replacement were included and randomised to infusion of either levosimendan @ g/kg/min or placebo from @ h before anaesthesia to the end of surgery .", "sentence_id": 5}
+{"abstract_id": "25348510", "label": "methods", "text": "Outcome measures were echocardiographic indices of left ventricular diastolic function : E/e ' ( primary endpoint ) , e ' , e ' / a ' and indices of systolic function : longitudinal strain , ejection fraction and s ' .", "sentence_id": 6}
+{"abstract_id": "25348510", "label": "methods", "text": "Patients were followed until @ months after surgery .", "sentence_id": 7}
+{"abstract_id": "25348510", "label": "methods", "text": "In addition , invasive haemodynamic measures were obtained perioperatively .", "sentence_id": 8}
+{"abstract_id": "25348510", "label": "results", "text": "The trial was prematurely terminated due to an overall high incidence of post-operative atrial fibrillation ( @/@ , P = @ ) after inclusion of @ patients .", "sentence_id": 9}
+{"abstract_id": "25348510", "label": "results", "text": "The relative decrease in perioperative cardiac index was lower ( P = @ ) in the levosimendan group .", "sentence_id": 10}
+{"abstract_id": "25348510", "label": "results", "text": "There was no difference in E/e ' , and similar results were found for all measures of systolic function .", "sentence_id": 11}
+{"abstract_id": "25348510", "label": "conclusions", "text": "Short-term levosimendan caused a transient relative increase in cardiac index , but no effect was seen on the first post-operative day and up to @ months post-operatively with indices of systolic and diastolic heart function .", "sentence_id": 12}
+{"abstract_id": "24746177", "label": "objective", "text": "Chemotherapy-induced nausea and vomiting ( CINV ) is an unanswered problem in cancer therapy .", "sentence_id": 0}
+{"abstract_id": "24746177", "label": "objective", "text": "We evaluated the efficacy and safety of triple antiemetic therapy with aprepitant , a @-hydroxytryptamine-@ ( @-HT ( @ ) ) receptor antagonist , and dexamethasone in patients with advanced non-small-cell lung cancer ( NSCLC ) who received carboplatin-based first-line chemotherapy .", "sentence_id": 1}
+{"abstract_id": "24746177", "label": "methods", "text": "Chemotherapy-nave patients with NSCLC were enrolled in this randomized phase-II study .", "sentence_id": 2}
+{"abstract_id": "24746177", "label": "methods", "text": "Patients were randomized to standard antiemetic therapy with a @-HT ( @ ) receptor antagonist and dexamethasone , and aprepitant add-on triple antiemetic therapy .", "sentence_id": 3}
+{"abstract_id": "24746177", "label": "methods", "text": "The primary endpoint was the complete response rate ( no vomiting and no rescue therapy ) during the @ h post-chemotherapy .", "sentence_id": 4}
+{"abstract_id": "24746177", "label": "results", "text": "A total of @ patients were assigned randomly to the aprepitant group or the control group .", "sentence_id": 5}
+{"abstract_id": "24746177", "label": "results", "text": "The aprepitant group and the control group showed an overall complete response rate of @ % ( @ % confidence interval ( CI ) , @-@ @ % ) and @ % ( @ % CI , @-@ @ % ; odds ratio ( OR ) , @ ; @ % CI , @-@ @ ; p = @ ) , respectively .", "sentence_id": 6}
+{"abstract_id": "24746177", "label": "results", "text": "Among patients taking carboplatin and pemetrexed , adding aprepitant significantly improved the complete response rate in the overall phase ( @ % in the aprepitant group and @ % in the control group ; OR , @ ; @ % CI , @-@ @ ; p < @ ) and the delayed phase ( @ % in the aprepitant group and @ % in the control group ; OR , @ ; @ % CI , @-@ @ ; p < @ ) .", "sentence_id": 7}
+{"abstract_id": "24746177", "label": "conclusions", "text": "Carboplatin-based chemotherapy has considerable emetic potential .", "sentence_id": 8}
+{"abstract_id": "24746177", "label": "conclusions", "text": "Triple antiemetic therapy with aprepitant , a @-HT ( @ ) receptor antagonist , and dexamethasone improved the control of CINV prevention in patients receiving carboplatin and pemetrexed chemotherapy .", "sentence_id": 9}
+{"abstract_id": "24854966", "label": "background", "text": "Shebeens in South Africa are settings in which alcohol use and sexual behavior often co-occur .", "sentence_id": 0}
+{"abstract_id": "24854966", "label": "background", "text": "The prevalence of alcohol use disorder ( AUD ) , and the association between AUD , situations and settings , and sexual risk behavior , in shebeens remains unknown .", "sentence_id": 1}
+{"abstract_id": "24854966", "label": "methods", "text": "Men ( n = @ ; mean age = @ ; @ % Black African ) were recruited from townships in Cape Town , South Africa and completed a self-administered survey that assessed alcohol use , sexual risk behaviors , and situations and settings of alcohol use .", "sentence_id": 2}
+{"abstract_id": "24854966", "label": "methods", "text": "The Alcohol Use Disorder and Associated Disabilities Interview Schedule DSV-IV Version ( AUDADIS-IV ) was used to identify the likelihood of AUD .", "sentence_id": 3}
+{"abstract_id": "24854966", "label": "methods", "text": "Bivariate regression analyses assessed whether screening for AUD predicted sexual risk behaviors .", "sentence_id": 4}
+{"abstract_id": "24854966", "label": "methods", "text": "Multivariate regression analyses examined whether AUD and/or situations/settings predicted risk behaviors .", "sentence_id": 5}
+{"abstract_id": "24854966", "label": "results", "text": "Nearly two-thirds of men ( @ % ) endorsed sufficient criteria for AUD ; @ % , @ % , and @ % were classified as having a mild , moderate , or severe AUD , respectively .", "sentence_id": 6}
+{"abstract_id": "24854966", "label": "results", "text": "AUD was associated with HIV risk such that men with AUD reported more unprotected sex than men without AUD .", "sentence_id": 7}
+{"abstract_id": "24854966", "label": "results", "text": "Analyses indicated that ( a ) individual ( i.e. , AUD ) and ( b ) settings ( i.e. , frequency of having sex with a partner in a shebeen , tavern , or bottle store ) interacted to predict unprotected sex .", "sentence_id": 8}
+{"abstract_id": "24854966", "label": "conclusions", "text": "The prevalence of AUD among shebeen patrons was high and was associated with unprotected sex .", "sentence_id": 9}
+{"abstract_id": "24854966", "label": "conclusions", "text": "Findings suggest the need to integrate both individual and situational/setting factors to prevent HIV among patrons of shebeens .", "sentence_id": 10}
+{"abstract_id": "25573021", "label": "background", "text": "Several endoscopic dilation techniques have been reported for treatment of anastomotic-stenosis of esophageal cancer , but the high incidence of dysphagia has remained unchanged .", "sentence_id": 0}
+{"abstract_id": "25573021", "label": "background", "text": "The aim of this study was to compare the effect of Argon Plasma Coagulation ( APC ) combined with Savary Bougienage ( SB ) compared to APC alone or SB alone for anastomotic-stenosis after radical operation for squamous cell carcinoma of the esophagus .", "sentence_id": 1}
+{"abstract_id": "25573021", "label": "methods", "text": "Patients with anastomotic-stenosis that was diagnosed for the first time following esophageal squamous cell carcinoma resection surgery were randomly assigned to undergo APC combined with SB , APC alone , or SB alone .", "sentence_id": 2}
+{"abstract_id": "25573021", "label": "methods", "text": "Primary endpoints were the dysphagia-free survival ( DFS defined as the time from first dilatation of effectively relieved dysphagia to dysphagia relapse expressed in days ) after @ months of follow up .", "sentence_id": 3}
+{"abstract_id": "25573021", "label": "results", "text": "A total of @ patients from the Cancer Institute , First Affiliated Hospital of Henan University of Science and Technology were entered into the study ( APC group , n = @ , SB group , n = @ , combination group -LSB- APC combined with SB -RSB- , n = @ ) .", "sentence_id": 4}
+{"abstract_id": "25573021", "label": "results", "text": "Primary endpoints : @ months after treatment , DFS of combination group ( @ days ; @ % CI , @-@ @ ) was significantly longer than the APC alone group ( @ days ; @ % CI , @-@ @ , p = @ ) and the SB alone group ( @ days ; @ % CI , @-@ @ , p = @ ) .", "sentence_id": 5}
+{"abstract_id": "25573021", "label": "results", "text": "No severe complications occurred within the three treatment groups .", "sentence_id": 6}
+{"abstract_id": "25573021", "label": "conclusions", "text": "APC combined with SB was a safe and well-tolerated method for relieving dysphagia of esophageal squamous cell cancer patients with anastomotic-stenosis .", "sentence_id": 7}
+{"abstract_id": "25573021", "label": "conclusions", "text": "( Registered with randomized controlled trials , ChiCRT , registration number ChiCTR-TRC-@ . )", "sentence_id": 8}
+{"abstract_id": "24556040", "label": "background", "text": "An unmet medical need exists for patients with metastatic renal cell carcinoma who have progressed on VEGF-targeted and mTOR-inhibitor therapies .", "sentence_id": 0}
+{"abstract_id": "24556040", "label": "background", "text": "Fibroblast growth factor ( FGF ) pathway activation has been proposed as a mechanism of escape from VEGF-targeted therapies .", "sentence_id": 1}
+{"abstract_id": "24556040", "label": "background", "text": "Dovitinib is an oral tyrosine-kinase inhibitor that inhibits VEGF and FGF receptors .", "sentence_id": 2}
+{"abstract_id": "24556040", "label": "background", "text": "We therefore compared dovitinib with sorafenib as third-line targeted therapies in patients with metastatic renal cell carcinoma .", "sentence_id": 3}
+{"abstract_id": "24556040", "label": "methods", "text": "In this multicentre phase @ study , patients with clear cell metastatic renal cell carcinoma who received one previous VEGF-targeted therapy and one previous mTOR inhibitor were randomly assigned through an interactive voice and web response system to receive open-label dovitinib ( @ mg orally according to a @-days-on and @-days-off schedule ) or sorafenib ( @ mg orally twice daily ) in a @:@ ratio .", "sentence_id": 4}
+{"abstract_id": "24556040", "label": "methods", "text": "Randomisation was stratified by risk group and region .", "sentence_id": 5}
+{"abstract_id": "24556040", "label": "methods", "text": "The primary endpoint was progression-free survival ( PFS ) assessed by masked central review .", "sentence_id": 6}
+{"abstract_id": "24556040", "label": "methods", "text": "Efficacy was assessed in all patients who were randomly assigned and safety was assessed in patients who received at least one dose of study drug .", "sentence_id": 7}
+{"abstract_id": "24556040", "label": "methods", "text": "This study is registered with ClinicalTrials.gov , number NCT@ .", "sentence_id": 8}
+{"abstract_id": "24556040", "label": "results", "text": "@ patients were randomly assigned to the dovitinib group and @ to the sorafenib group .", "sentence_id": 9}
+{"abstract_id": "24556040", "label": "results", "text": "Median follow-up was @ months ( IQR @-@ ) .", "sentence_id": 10}
+{"abstract_id": "24556040", "label": "results", "text": "Median PFS was @ months ( @ % CI @-@ ) in the dovitinib group and @ months ( @-@ ) in the sorafenib group ( hazard ratio @ , @ % CI @-@ ; one-sided p = @ ) .", "sentence_id": 11}
+{"abstract_id": "24556040", "label": "results", "text": "@ patients in the dovitinib group and @ in the sorafenib group received at least one dose of study drug .", "sentence_id": 12}
+{"abstract_id": "24556040", "label": "results", "text": "Common grade @ or @ adverse events included hypertriglyceridaemia ( @ -LSB- @ % -RSB- ) , fatigue ( @ -LSB- @ % -RSB- ) , hypertension ( @ -LSB- @ % -RSB- ) , and diarrhoea ( @ -LSB- @ % -RSB- ) in the dovitinib group , and hypertension ( @ -LSB- @ % -RSB- ) , fatigue ( @ -LSB- @ % -RSB- ) , dyspnoea ( @ -LSB- @ % -RSB- ) , and palmar-plantar erythrodysaesthesia ( @ -LSB- @ % -RSB- ) in the sorafenib group .", "sentence_id": 13}
+{"abstract_id": "24556040", "label": "results", "text": "The most common serious adverse event was dyspnoea ( @ -LSB- @ % -RSB- and @ -LSB- @ % -RSB- in the dovitinib and sorafenib groups , respectively ) .", "sentence_id": 14}
+{"abstract_id": "24556040", "label": "conclusions", "text": "Dovitinib showed activity , but this was no better than that of sorafenib in patients with renal cell carcinoma who had progressed on previous VEGF-targeted therapies and mTOR inhibitors .", "sentence_id": 15}
+{"abstract_id": "24556040", "label": "conclusions", "text": "This trial provides reference outcome data for future studies of targeted inhibitors in the third-line setting .", "sentence_id": 16}
+{"abstract_id": "24490977", "label": "background", "text": "Recruitment is one of the most serious challenges in performing randomized controlled trials .", "sentence_id": 0}
+{"abstract_id": "24490977", "label": "background", "text": "Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitment challenges resulting in a considerable waste of resources in the form of time , funding , and the participants ' efforts .", "sentence_id": 1}
+{"abstract_id": "24490977", "label": "background", "text": "Dropout rates in schizophrenia trials are also high.Recruitment challenges are often due to patients not wanting to participate in research but can also be due to clinicians ' concerns regarding individuals diagnosed with schizophrenia as participants in research .", "sentence_id": 2}
+{"abstract_id": "24490977", "label": "background", "text": "This paper reports how overcoming recruitment challenges not related to patients revealed high readiness to take part and low dropout rates in a one year long randomized controlled trial testing Guided Self-Determination ( GSD ) among outpatients with schizophrenia receiving treatment in Assertive Outreach Teams in the northern part of Denmark .", "sentence_id": 3}
+{"abstract_id": "24490977", "label": "methods", "text": "GSD is a shared decision-making and mutual problem-solving method using reflection sheets , which was developed in diabetes care and adjusted for this study and utilized by patients with schizophrenia .", "sentence_id": 4}
+{"abstract_id": "24490977", "label": "methods", "text": "Descriptive data on strategies to overcome recruitment challenges were derived from notes and observations made during the randomized controlled trial testing of GSD in six outpatient teams .", "sentence_id": 5}
+{"abstract_id": "24490977", "label": "results", "text": "Three types of recruitment challenges not related to patients were identified and met during the trial : @ ) organizational challenges , @ ) challenges with finding eligible participants and @ ) challenges with having professionals invite patients to participate .", "sentence_id": 6}
+{"abstract_id": "24490977", "label": "results", "text": "These challenges were overcome through : @ ) extension of time , @ ) expansion of the clinical recruitment area and @ ) encouragement of professionals to invite patients to the study .", "sentence_id": 7}
+{"abstract_id": "24490977", "label": "results", "text": "Through overcoming these challenges , we identified a remarkably high patient-readiness to take part ( @ of @ asked accepted ) and a low dropout rate ( @ % ) .", "sentence_id": 8}
+{"abstract_id": "24490977", "label": "conclusions", "text": "Distinction between recruitment challenges was important in discovering the readiness among patients with schizophrenia to take part in and complete a trial with the GSD-intervention .", "sentence_id": 9}
+{"abstract_id": "24882370", "label": "objective", "text": "The main aim was to assess the effects of a spa treatment on the resumption of occupational and non-occupational activities and the abilities of women in breast cancer remission .", "sentence_id": 0}
+{"abstract_id": "24882370", "label": "objective", "text": "A cost-effectiveness analysis ( CEA ) was also performed .", "sentence_id": 1}
+{"abstract_id": "24882370", "label": "methods", "text": "A multicentre randomised controlled trial was carried out between @ and @ in the University Hospital of Auvergne and two private hospitals in Clermont-Ferrand , France .", "sentence_id": 2}
+{"abstract_id": "24882370", "label": "methods", "text": "Eligible patients were women in complete breast cancer remission without contraindication for physical activities or cognitive disorders and a body mass index between @ and @ kg/m ( @ ) .", "sentence_id": 3}
+{"abstract_id": "24882370", "label": "methods", "text": "The intervention group underwent spa treatment combined with consultation with dietician whereas the control underwent consultations with the dietician only .", "sentence_id": 4}
+{"abstract_id": "24882370", "label": "methods", "text": "Of the @ patients randomised , @ and @ were included in the intervention and the control groups , respectively .", "sentence_id": 5}
+{"abstract_id": "24882370", "label": "methods", "text": "The CEA involved @ patients , @ from the intervention group and @ from the control group .", "sentence_id": 6}
+{"abstract_id": "24882370", "label": "results", "text": "The main results showed a higher rate of resumption of occupational activities in the intervention group ( p = @ ) and a positive effect of the intervention on the women 's ability to perform occupational activities @ months after the beginning of the study ( p = @ ) , and on their ability to perform family activities ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24882370", "label": "results", "text": "The stay in a thermal centre was cost-effective at @ months .", "sentence_id": 8}
+{"abstract_id": "24882370", "label": "conclusions", "text": "Spa treatment is a cost-effective strategy to improve resumption of occupational and non-occupational activities and the abilities of women in breast cancer remission .", "sentence_id": 9}
+{"abstract_id": "25179753", "label": "objective", "text": "Medical treatment settings such as emergency departments ( EDs ) present important opportunities to address problematic substance use .", "sentence_id": 0}
+{"abstract_id": "25179753", "label": "objective", "text": "Currently , EDs do not typically intervene beyond acute medical stabilization .", "sentence_id": 1}
+{"abstract_id": "25179753", "label": "objective", "text": "To contrast the effects of a brief intervention with telephone boosters ( BI-B ) with those of screening , assessment , and referral to treatment ( SAR ) and minimal screening only ( MSO ) among drug-using ED patients .", "sentence_id": 2}
+{"abstract_id": "25179753", "label": "methods", "text": "Between October @ and February @ , @ adult ED patients from @ US academic hospitals , who scored @ or greater on the @-item Drug Abuse Screening Test ( indicating moderate to severe problems related to drug use ) and who were currently using drugs , were randomized to MSO ( n = @ ) , SAR ( n = @ ) , or BI-B ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "25179753", "label": "methods", "text": "Follow-up assessments were conducted at @ , @ , and @ months by blinded interviewers .", "sentence_id": 4}
+{"abstract_id": "25179753", "label": "methods", "text": "Following screening , MSO participants received only an informational pamphlet .", "sentence_id": 5}
+{"abstract_id": "25179753", "label": "methods", "text": "The SAR participants received assessment plus referral to addiction treatment if indicated , and the BI-B participants received assessment and referral as in SAR , plus a manual-guided counseling session based on motivational interviewing principles and up to @ `` booster '' sessions by telephone during the month following the ED visit .", "sentence_id": 6}
+{"abstract_id": "25179753", "label": "methods", "text": "Outcomes evaluated at follow-up visits included self-reported days using the patient-defined primary problem drug , days using any drug , days of heavy drinking , and drug use based on analysis of hair samples .", "sentence_id": 7}
+{"abstract_id": "25179753", "label": "methods", "text": "The primary outcome was self-reported days of use of the patient-defined primary problem drug during the @-day period preceding the @-month follow-up .", "sentence_id": 8}
+{"abstract_id": "25179753", "label": "results", "text": "Follow-up rates were @ % , @ % , and @ % at @ , @ , and @ months , respectively .", "sentence_id": 9}
+{"abstract_id": "25179753", "label": "results", "text": "For the primary outcome , estimated differences in number of days of use ( @ % CI ) were as follows : MSO vs BI-B , @ ( -@ to @ ) , P ( adjusted ) = @ ; SAR vs BI-B , @ ( -@ to @ ) , P ( adjusted ) = @ ; SAR vs MSO , -@ ( -@ to @ ) , P ( adjusted ) = @ .", "sentence_id": 10}
+{"abstract_id": "25179753", "label": "results", "text": "There were no significant differences between groups in self-reported days using the primary drug , days using any drug , or heavy drinking days at @ , @ , or @ months .", "sentence_id": 11}
+{"abstract_id": "25179753", "label": "results", "text": "At the @-month follow-up , participants in the SAR group had a higher rate of hair samples positive for their primary drug of abuse ( @ of @ -LSB- @ % -RSB- ) than did participants in the MSO group ( @ of @ -LSB- @ % -RSB- ) or the BI-B group ( @ of @ -LSB- @ % -RSB- ) .", "sentence_id": 12}
+{"abstract_id": "25179753", "label": "results", "text": "Hair analysis differences between groups at other time points were not significant .", "sentence_id": 13}
+{"abstract_id": "25179753", "label": "conclusions", "text": "In this sample of drug users seeking emergency medical treatment , a relatively robust brief intervention did not improve substance use outcomes .", "sentence_id": 14}
+{"abstract_id": "25179753", "label": "conclusions", "text": "More work is needed to determine how drug use disorders may be addressed effectively in the ED .", "sentence_id": 15}
+{"abstract_id": "24556530", "label": "background", "text": "The `` m '' in mHealth is often thought of as the ability to receive health information and monitor behaviors on the go .", "sentence_id": 0}
+{"abstract_id": "24556530", "label": "background", "text": "Little is known about how people actually use mobile vs. traditional access methods and if access method affects engagement and health outcomes .", "sentence_id": 1}
+{"abstract_id": "24556530", "label": "methods", "text": "This study examines the @-month outcomes of two mobile weight loss interventions ( Pounds Off Digitally ( POD ) and mobile POD ( mPOD ) ) where participants were required to own a mobile device for study entry and received weight loss information via podcast .", "sentence_id": 2}
+{"abstract_id": "24556530", "label": "methods", "text": "Only participants in both studies who were randomized to receive the same theory-based podcast ( TBP ) were used in this analysis .", "sentence_id": 3}
+{"abstract_id": "24556530", "label": "methods", "text": "In POD , @ participants were randomized to the TBP condition ( @ to a control not included in this analyses ) .", "sentence_id": 4}
+{"abstract_id": "24556530", "label": "methods", "text": "In mPOD , @ participants were randomized to the TBP ( n = @ ) and @ to the TBP + mobile group ( a self-monitoring app and Twitter app for social support ) .", "sentence_id": 5}
+{"abstract_id": "24556530", "label": "methods", "text": "The goal of this study is to examine how participants accessed study components and to examine how type of device impacts engagement and weight loss .", "sentence_id": 6}
+{"abstract_id": "24556530", "label": "results", "text": "Examining data from both studies in aggregate , despite a mobile delivery method , @ % of participants reported using a non-mobile device to access the majority of the podcasts ( desktop computers ) , @ % accessed the podcasts mostly at their home or work , and @ % were mainly non-mobile ( e.g. , sitting at work ) when listening .", "sentence_id": 7}
+{"abstract_id": "24556530", "label": "results", "text": "Examining objective download data for mPOD , @ % of downloads ( @/@ ) originated from non-mobile delivery methods vs. mobile platforms ( @/@ ) .", "sentence_id": 8}
+{"abstract_id": "24556530", "label": "results", "text": "At @ months , @ % of Twitter posts originated from the website ( n = @ posts ) vs. a mobile app ( n = @ ; @ % ) .", "sentence_id": 9}
+{"abstract_id": "24556530", "label": "results", "text": "There was no difference in the number of podcasts participants reported listening to by device .", "sentence_id": 10}
+{"abstract_id": "24556530", "label": "results", "text": "There were more Twitter posts by mobile app users ( @ ) than Twitter website users ( @ , p < @ ) .", "sentence_id": 11}
+{"abstract_id": "24556530", "label": "results", "text": "There was a trend ( p = @ ) in greater weight loss among mobile users for podcasts ( -@ % ) as compared to non-mobile users ( -@ % ) .", "sentence_id": 12}
+{"abstract_id": "24556530", "label": "results", "text": "Weight loss was significantly greater in Twitter mobile app users ( -@ % ) than website users ( -@ % , p < @ ) .", "sentence_id": 13}
+{"abstract_id": "24556530", "label": "conclusions", "text": "Type of device used for podcast listening did not affect engagement but there was a trend toward greater weight loss among mobile users .", "sentence_id": 14}
+{"abstract_id": "24556530", "label": "conclusions", "text": "Method of Twitter posting was associated with engagement and weight loss with mobile app users posting more to Twitter and losing more weight .", "sentence_id": 15}
+{"abstract_id": "25163948", "label": "objective", "text": "To compare outcome after total hip arthroplasty ( THA ) through the mini-incision approach versus the standard transgluteal approach .", "sentence_id": 0}
+{"abstract_id": "25163948", "label": "methods", "text": "@ women and @ men aged @ to @ ( mean , @ ) years with primary osteoarthritis of the hip were randomised to undergo unilateral THA through a mini-incision approach ( Micro-hip , n = @ ) or standard , lateral , transgluteal approach ( Bauer , n = @ ) .", "sentence_id": 1}
+{"abstract_id": "25163948", "label": "methods", "text": "Levels of haemoglobin , haematocrit , serum creatine kinase , and C-reactive protein , length of hospital stay , mobilisation , and any complication were recorded .", "sentence_id": 2}
+{"abstract_id": "25163948", "label": "methods", "text": "Visual analogue scale ( VAS ) for pain was assessed .", "sentence_id": 3}
+{"abstract_id": "25163948", "label": "methods", "text": "Hip function was assessed using the Harris Hip Score and the Oxford Hip Score , whereas general health was assessed using the EQ-@D general health questionnaire .", "sentence_id": 4}
+{"abstract_id": "25163948", "label": "methods", "text": "The cup inclination and varus/valgus of the stem position were measured using a goniometer .", "sentence_id": 5}
+{"abstract_id": "25163948", "label": "results", "text": "The Micro-hip group achieved a significantly lower mean incision length ( @ vs. @ cm , p < @ ) , mean surgical time ( @ vs. @ minutes , p = @ ) , mean reduction in haemoglobin level ( @ vs. @ g/dl , p < @ ) , and mean VAS for pain from hour @ to day @ ( all p < @ ) .", "sentence_id": 6}
+{"abstract_id": "25163948", "label": "results", "text": "One patient in the Micro-hip group developed early aseptic loosening of the cup and underwent revision surgery at month @ .", "sentence_id": 7}
+{"abstract_id": "25163948", "label": "results", "text": "Three patients in the Bauer group and one patient in the Micro-hip group sustained intra-operative nondisplaced fractures of the proximal femur , which were fixed with cerclages .", "sentence_id": 8}
+{"abstract_id": "25163948", "label": "results", "text": "Two patients in the Microhip group developed deep vein thrombosis during week @ .", "sentence_id": 9}
+{"abstract_id": "25163948", "label": "conclusions", "text": "THA through the Micro-hip approach achieved faster pain relief .", "sentence_id": 10}
+{"abstract_id": "25511185", "label": "background", "text": "Chronic low back pain ( LBP ) and neck pain ( NP ) are highly prevalent conditions resulting in high economic costs .", "sentence_id": 0}
+{"abstract_id": "25511185", "label": "background", "text": "Treatment guidelines recommend relaxation techniques , such as progressive muscle relaxation , as adjuvant therapies .", "sentence_id": 1}
+{"abstract_id": "25511185", "label": "background", "text": "Self-care interventions could have the potential to reduce costs in the health care system , but their effectiveness , especially in a usual care setting , is unclear .", "sentence_id": 2}
+{"abstract_id": "25511185", "label": "background", "text": "The aim of these two pragmatic randomized studies is to evaluate whether an additional app-delivered relaxation is more effective in the reduction of chronic LBP or NP than usual care alone .", "sentence_id": 3}
+{"abstract_id": "25511185", "label": "methods", "text": "Each pragmatic randomized two-armed study aims to include a total of @ patients aged @ to @ years with chronic ( > @ weeks ) LBP or NP and an average pain intensity of@ on a numeric rating scale ( NRS ) in the @ days before recruitment .", "sentence_id": 4}
+{"abstract_id": "25511185", "label": "methods", "text": "The participants will be randomized into an intervention and a usual care group .", "sentence_id": 5}
+{"abstract_id": "25511185", "label": "methods", "text": "The intervention group will be instructed to practice one of these @ relaxation techniques on at least @ days/week for @ minutes/day over a period of @ months starting on the day of randomization : autogenic training , mindfulness meditation , or guided imagery .", "sentence_id": 6}
+{"abstract_id": "25511185", "label": "methods", "text": "Instructions and exercises will be provided using a smartphone app , baseline information will be collected using paper and pencil .", "sentence_id": 7}
+{"abstract_id": "25511185", "label": "methods", "text": "Follow-up information ( daily , weekly , and after @ and @ months ) will be collected using electronic diaries and questionnaires included in the app .", "sentence_id": 8}
+{"abstract_id": "25511185", "label": "methods", "text": "The primary outcome measure will be the mean LBP or NP intensity during the first @ months of intervention based on daily pain intensity measurements on a NRS ( @ = no pain , @ = worst possible pain ) .", "sentence_id": 9}
+{"abstract_id": "25511185", "label": "methods", "text": "The secondary outcome parameters will include the mean pain intensity during the first @ months after randomization based on daily measurements , the mean pain intensity measured weekly as the average pain intensity of the previous @ days over @ and @ months , pain acceptance , ` LBP - and NP-related ' stress , sick leave days , pain medication intake , adherence , suspected adverse reaction , and serious adverse events .", "sentence_id": 10}
+{"abstract_id": "25511185", "label": "conclusions", "text": "The designed studies reflect a usual self-care setting and will provide evidence on a pragmatic self-care intervention that is easy to combine with care provided by medical professionals .", "sentence_id": 11}
+{"abstract_id": "25092964", "label": "background", "text": "Migraine is a painful neurological disorder that affects over @ % of the general population .", "sentence_id": 0}
+{"abstract_id": "25092964", "label": "background", "text": "Frovatriptan and rizatriptan are antimigraine agents belonging to the triptan class .", "sentence_id": 1}
+{"abstract_id": "25092964", "label": "background", "text": "Although previous studies have independently compared the efficacy of these agents , contemporaneous data examining both pharmacokinetic ( PK ) properties and efficacy in parallel have not previously been available .", "sentence_id": 2}
+{"abstract_id": "25092964", "label": "methods", "text": "In this single-center double-blind study , @ subjects ( ten female ) were treated for a single migraine attack with frovatriptan @ mg or rizatriptan @ mg .", "sentence_id": 3}
+{"abstract_id": "25092964", "label": "methods", "text": "Plasma concentrations were measured predose and at @ , @ , @ , @ , @ , @ , and @ hours after drug administration .", "sentence_id": 4}
+{"abstract_id": "25092964", "label": "methods", "text": "The primary end point of this study was to evaluate the association between PK parameters and efficacy measures and recurrence rate .", "sentence_id": 5}
+{"abstract_id": "25092964", "label": "methods", "text": "Secondary end points were pain-free and pain-relief episodes at @ and @ hours , recurrent episodes within @ hours , and cumulative hazard of recurrence within @ hours .", "sentence_id": 6}
+{"abstract_id": "25092964", "label": "results", "text": "At baseline , approximately @ % of patients had mild migraine , while @ % had moderate-severe migraine .", "sentence_id": 7}
+{"abstract_id": "25092964", "label": "results", "text": "Although the time to maximum concentration was similar for both drugs ( @ versus @ hours ) , the terminal half-life for frovatriptan was longer than rizatriptan ( @ versus @ hours , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25092964", "label": "results", "text": "The proportion of patients who were pain-free at @ hours without rescue medication was higher in the frovatriptan-treated group , ( @ versus @ % , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25092964", "label": "results", "text": "The cumulative hazard of recurrence over @ h was reduced by frovatriptan compared to rizatriptan-treated patients ( log-rank test , P = @ ) .", "sentence_id": 10}
+{"abstract_id": "25092964", "label": "results", "text": "Pain-free and pain-relief episodes for the study period were positively correlated with the concentration : maximum concentration ( Cmax ) ratio for frovatriptan ( r = @ , P = @ ) , but not rizatriptan .", "sentence_id": 11}
+{"abstract_id": "25092964", "label": "results", "text": "Recurrence rate was negatively correlated with the concentration : Cmax ratio for both frovatriptan ( r = -@ , P = @ ) and rizatriptan ( r = -@ , P = @ ) .", "sentence_id": 12}
+{"abstract_id": "25092964", "label": "results", "text": "Fewer adverse events were observed for frovatriptan compared to rizatriptan ( one versus eight , P = @ ) .", "sentence_id": 13}
+{"abstract_id": "25092964", "label": "conclusions", "text": "This pilot study indicates that a similar extent of initial pain relief is afforded by both triptans in migraine treatment .", "sentence_id": 14}
+{"abstract_id": "25092964", "label": "conclusions", "text": "The longer duration of action of frovatriptan parallels and correlates with its PK profile .", "sentence_id": 15}
+{"abstract_id": "25667159", "label": "objective", "text": "The @ guidelines recommend new requirements of the chest compression depth for infant .", "sentence_id": 0}
+{"abstract_id": "25667159", "label": "objective", "text": "The compression technique recommendation for infant remains the @-finger ( TF ) technique for lone rescuer and the @-thumb-encircling hands technique for @ rescuers .", "sentence_id": 1}
+{"abstract_id": "25667159", "label": "objective", "text": "We hypothesized that the TF technique can not result in an enough compression depth to meet the guideline requirements and that the @-thumb-encircling hands technique will not affect the ventilation .", "sentence_id": 2}
+{"abstract_id": "25667159", "label": "methods", "text": "Crossover experimental study randomizes @ health care providers to perform @ sets of @-minute cardiopulmonary resuscitation using a @:@ compression/ventilation ratio to compare TF and @-thumb-encircling hands techniques .", "sentence_id": 3}
+{"abstract_id": "25667159", "label": "methods", "text": "A Laerdal Resusci Baby QCPR manikin equipped with PC SkillReporting System was used for measuring and recording cardiopulmonary resuscitation data .", "sentence_id": 4}
+{"abstract_id": "25667159", "label": "methods", "text": "Data ( mean SD ) were analyzed by using a paired t test .", "sentence_id": 5}
+{"abstract_id": "25667159", "label": "methods", "text": "Significance was defined qualitatively as P @ .", "sentence_id": 6}
+{"abstract_id": "25667159", "label": "results", "text": "Mean compression depths were @ @ cm in the TF technique and @ @ cm in the @-thumb-encircling hands technique , P < @ .", "sentence_id": 7}
+{"abstract_id": "25667159", "label": "results", "text": "Two-finger technique had significant lower fractions of correct hand position than @-thumb-encircling hands technique ( @ % @ % vs @ % @ % , P < @ ) .", "sentence_id": 8}
+{"abstract_id": "25667159", "label": "results", "text": "The fatigue point appears much earlier in TF than in @-thumb-encircling hands .", "sentence_id": 9}
+{"abstract_id": "25667159", "label": "results", "text": "No difference was identified on ventilation between @ groups .", "sentence_id": 10}
+{"abstract_id": "25667159", "label": "conclusions", "text": "The @-thumb-encircling hands technique can produce a compression depth meeting the current guidelines recommendation without negative influence on ventilation , whereas the TF technique can not .", "sentence_id": 11}
+{"abstract_id": "25667159", "label": "conclusions", "text": "The @-thumb-encircling hands technique generates a significant higher ratio of correct compression position than the TF technique .", "sentence_id": 12}
+{"abstract_id": "25667159", "label": "conclusions", "text": "Furthermore , the @-thumb-encircling hands technique is less fatiguing than the TF technique .", "sentence_id": 13}
+{"abstract_id": "24640801", "label": "objective", "text": "To evaluate the biochemical changes associated with succinylcholine administration after pretreatment with rocuronium at different time intervals .", "sentence_id": 0}
+{"abstract_id": "24640801", "label": "methods", "text": "The prospective , randomised , single-blinded study was conducted at the Combined Military Hospital , Rawalpindi , from January to May @ .", "sentence_id": 1}
+{"abstract_id": "24640801", "label": "methods", "text": "Ninety male , aged @-@ years , American Society of Anaesthesiology I or II patients undergoing elective inguinal herniotomy or external haemorrhoidectomy were included .", "sentence_id": 2}
+{"abstract_id": "24640801", "label": "methods", "text": "The patients were randomly divided into three equal groups .", "sentence_id": 3}
+{"abstract_id": "24640801", "label": "methods", "text": "Group A received a normal saline @ ml as placebo @ minute before succinylcholine ; Group B received rocuronium @ mg/kg @ intravenously minute before succinylcholine , while Group C received intravenous injection of rocuronium @ mg/kg @ minute before succinylcholine .", "sentence_id": 4}
+{"abstract_id": "24640801", "label": "methods", "text": "Venous blood samples for creatinine phosphokinase , lactate dehydrogenase and myoglobin plasma concentrations were obtained at @ , @ minutes , @ hours and @ hours after succinylcholine administration .", "sentence_id": 5}
+{"abstract_id": "24640801", "label": "results", "text": "Mean serum creatinine phosphokinase and myoglobin concentrations were significantly decreased in Groups B and C compared to Group A at @ minutes and @ hours ( p < @ ) .", "sentence_id": 6}
+{"abstract_id": "24640801", "label": "results", "text": "However , no significant difference in the enzyme levels at any time interval was observed among the rocuronium groups .", "sentence_id": 7}
+{"abstract_id": "24640801", "label": "results", "text": "There was a significant rise in lactate dehydrogenase concentrations at @ hours and @ hours in Group A compared to Groups B and C ( p < @ ) .", "sentence_id": 8}
+{"abstract_id": "24640801", "label": "conclusions", "text": "Pretreatment with rocuronium effectively reduces the biochemical changes associated with succinylcholine-induced muscle fasciculations .", "sentence_id": 9}
+{"abstract_id": "24640801", "label": "conclusions", "text": "However , whether it is given @ minute or @ minutes before succinylcholine does not make much difference .", "sentence_id": 10}
+{"abstract_id": "24866311", "label": "objective", "text": "Obesity in children and adolescents is associated to a morbidity that has increased significantly .", "sentence_id": 0}
+{"abstract_id": "24866311", "label": "objective", "text": "It has become a public health problem around the world .", "sentence_id": 1}
+{"abstract_id": "24866311", "label": "objective", "text": "The objective of this paper was to evaluate the efficacy of the cognitive behavioral treatment strategy in the comprehensive management of obesity in adolescents .", "sentence_id": 2}
+{"abstract_id": "24866311", "label": "methods", "text": "Double blind , randomized , and controlled intervention study , of four months of follow-up , with a total of @ obese adolescents , aged @ to @ years .", "sentence_id": 3}
+{"abstract_id": "24866311", "label": "methods", "text": "The intervention group received cognitive behavioral treatment strategy , as well as advise on diet and exercise .", "sentence_id": 4}
+{"abstract_id": "24866311", "label": "methods", "text": "At the same time , the control group only received advise on diet and exercise .", "sentence_id": 5}
+{"abstract_id": "24866311", "label": "results", "text": "The percentage of adolescents who showed adherence to diet was @ % versus @ % , ( p = @ ) and to exercise , @ % versus @ % , ( p < @ ) ; compared with the control group , the intervention group was significantly higher .", "sentence_id": 6}
+{"abstract_id": "24866311", "label": "results", "text": "A total of @ adolescents ( @ % ) in the intervention group and @ ( @ % ) in the control group dropped-out ( p = @ ) .", "sentence_id": 7}
+{"abstract_id": "24866311", "label": "results", "text": "Despite there were significant differences between groups , adolescents in the intervention group exhibited a higher and sustained decrease in body weight , body mass index , as well as in the body fat percentage .", "sentence_id": 8}
+{"abstract_id": "24866311", "label": "conclusions", "text": "The cognitive behavioral treatment strategy improves adherence and decreases desertion of the weight reduction program in adolescents .", "sentence_id": 9}
+{"abstract_id": "24260129", "label": "objective", "text": "The present study aimed to investigate the prevalence and correlates of dental caries in elderly population in northeast China .", "sentence_id": 0}
+{"abstract_id": "24260129", "label": "methods", "text": "A community-based , cross-sectional study among @ elderly subjects ( age : @-@ years ) from nine urban areas and nine rural areas in three provinces of northeast China was conducted using multistage stratified random sampling per the World Health Organization oral health survey methodology .", "sentence_id": 1}
+{"abstract_id": "24260129", "label": "methods", "text": "Decayed-missing-filled teeth ( DMFT ) and decayed-filled teeth ( DFT ) indices were used to evaluate the prevalence of dental caries .", "sentence_id": 2}
+{"abstract_id": "24260129", "label": "methods", "text": "Face-to-face questionnaire survey on oral health was performed in a randomly selected subset ( n = @ ) .", "sentence_id": 3}
+{"abstract_id": "24260129", "label": "methods", "text": "T test and chi square test were employed to compare groups for continuous and categorical variables , respectively .", "sentence_id": 4}
+{"abstract_id": "24260129", "label": "methods", "text": "Multivariate logistic regression was used to estimate odds ratios ( ORs ) and corresponding confidence intervals ( CIs ) .", "sentence_id": 5}
+{"abstract_id": "24260129", "label": "results", "text": "@ % of elderly subjects reported dental caries ( average DFT = @ ) , and the prevalence was higher in urban areas ( P < @ ) .", "sentence_id": 6}
+{"abstract_id": "24260129", "label": "results", "text": "Missing teeth accounted for @ % of DMFT , and filled teeth due to caries accounted for @ % with a rate higher in urban areas ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24260129", "label": "results", "text": "Logistic regression analysis indicated significant association among elderly population in urban areas ( OR @ ; @ % CI @-@ @ ) , smoking ( OR @ ; @ % CI @-@ @ ) , and individuals without dental insurance ( OR @ ; @ % CI @-@ @ ) with dental caries .", "sentence_id": 8}
+{"abstract_id": "24260129", "label": "conclusions", "text": "The prevalence of dental caries in the elderly population in northeast China is high .", "sentence_id": 9}
+{"abstract_id": "24260129", "label": "conclusions", "text": "The elderly from urban areas who smoke and who do not have a dental insurance are at a higher risk to develop dental caries .", "sentence_id": 10}
+{"abstract_id": "24796043", "label": "objective", "text": "To observe the short-term and long-term efficacies on primary dysmenorrhea treated with staging acupoint embedment therapy .", "sentence_id": 0}
+{"abstract_id": "24796043", "label": "methods", "text": "Seventy cases of primary dysmenorrhea were randomized into an embedment therapy group and a fenbid group , @ cases in each one .", "sentence_id": 1}
+{"abstract_id": "24796043", "label": "methods", "text": "In the embedment therapy group , the embedment therapy was applied twice during the menstrual cycle , one treatment @ days before menstruation and one treatment during the @th-@th days of menstruation , respectively .", "sentence_id": 2}
+{"abstract_id": "24796043", "label": "methods", "text": "Guanyuan ( CV @ ) , Zigong ( EX-CA @ ) , Diji ( SP @ ) and Ciliao ( BL @ ) were the main acupoints in the treatment @ days before menstruation .", "sentence_id": 3}
+{"abstract_id": "24796043", "label": "methods", "text": "Shenshu ( BL @ ) , Ganshu ( BL @ ) and Pishu ( BL @ ) were the main acupoints in the treatment during menstruation .", "sentence_id": 4}
+{"abstract_id": "24796043", "label": "methods", "text": "In the fenbid group , fenbid was prescribed for oral administration , @ g each time , twice a day , starting @ days before menstruation till pain was relieved .", "sentence_id": 5}
+{"abstract_id": "24796043", "label": "methods", "text": "The treatment of one menstrual cycle was one session .", "sentence_id": 6}
+{"abstract_id": "24796043", "label": "methods", "text": "The continuous treatment of @ menstrual cycles was required .", "sentence_id": 7}
+{"abstract_id": "24796043", "label": "methods", "text": "The short-term and long-term efficacies were evaluated at the end of the @rd cycle and in @ months after the treatment terminal .", "sentence_id": 8}
+{"abstract_id": "24796043", "label": "methods", "text": "The dysmenorrhea score was used to evaluate the efficacy .", "sentence_id": 9}
+{"abstract_id": "24796043", "label": "methods", "text": "Visual analogue scale ( VAS ) and SF-@ were for the assessment of pain degree and life quality .", "sentence_id": 10}
+{"abstract_id": "24796043", "label": "results", "text": "( @ ) The total effective rate was @ % ( @/@ ) in the embedment therapy group after the @ menstrual cycles , which was better than @ % ( @/@ ) in the fenbid group ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24796043", "label": "results", "text": "In the follow-up stage , the total effective rate was @ % ( @/@ ) in the embedment therapy group , which was better than @ % ( @/@ ) in the fenbid group ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24796043", "label": "results", "text": "( @ ) The differences were not significant in dysmenorrhea score and VAS score after the @st and @nd menstrual cycle treatments between the two groups ( all P > @ ) .", "sentence_id": 13}
+{"abstract_id": "24796043", "label": "results", "text": "In the @rd menstrual cycle and the follow-up stage , the dysmenorrhea score and VAS score were reduced obviously in the embedment therapy group as compared with those in the fenbid group ( P < @ , P < @ ) .", "sentence_id": 14}
+{"abstract_id": "24796043", "label": "results", "text": "The rebound effect occurred in the follow-up stage in the fenbid group .", "sentence_id": 15}
+{"abstract_id": "24796043", "label": "results", "text": "( @ ) In the @rd menstrual cycle and the follow-up stage , the improvement in the total score of life quality of the embedment therapy group was superior apparently to the fenbid group ( P < @ , P < @ ) .", "sentence_id": 16}
+{"abstract_id": "24796043", "label": "conclusions", "text": "The staging acupoint embedment therapy achieves the superior short-term and long-term efficacies as compared with the oral administration of fenbid in the treatment of primary dysmenorrhea .", "sentence_id": 17}
+{"abstract_id": "24796043", "label": "conclusions", "text": "As the symptoms of dysmenorrhea and pain are relieved , the life quality is improved .", "sentence_id": 18}
+{"abstract_id": "24439238", "label": "background", "text": "In-patient treatment ( IP ) is the treatment setting of choice for moderately-to-severely ill adolescents with anorexia nervosa , but it is costly , and the risks of relapse and readmissions are high .", "sentence_id": 0}
+{"abstract_id": "24439238", "label": "background", "text": "Day patient treatment ( DP ) is less expensive and might avoid problems of relapse and readmission by easing the transition from hospital to home .", "sentence_id": 1}
+{"abstract_id": "24439238", "label": "background", "text": "We investigated the safety and efficacy of DP after short inpatient care compared with continued IP .", "sentence_id": 2}
+{"abstract_id": "24439238", "label": "methods", "text": "For this multicentre , randomised , open-label , non-inferiority trial , we enrolled female patients ( aged @-@ years ) with anorexia nervosa from six centres in Germany .", "sentence_id": 3}
+{"abstract_id": "24439238", "label": "methods", "text": "Patients were eligible if they had a body-mass index ( BMI ) below the tenth percentile and it was their first admission to hospital for anorexia nervosa .", "sentence_id": 4}
+{"abstract_id": "24439238", "label": "methods", "text": "We used a computer-generated randomisation sequence to randomly assign patients to continued IP or DP after @ weeks of inpatient care ( @:@ ; stratified for age and BMI at admission ) .", "sentence_id": 5}
+{"abstract_id": "24439238", "label": "methods", "text": "The treatment programme and treatment intensity in both study groups were identical .", "sentence_id": 6}
+{"abstract_id": "24439238", "label": "methods", "text": "The primary outcome was the increase in BMI between the time of admission and a @-month follow-up adjusted for age and duration of illness ( non-inferiority margin of @ kg/m ( @ ) ) .", "sentence_id": 7}
+{"abstract_id": "24439238", "label": "methods", "text": "Analysis was done by modified intention to treat .", "sentence_id": 8}
+{"abstract_id": "24439238", "label": "methods", "text": "This trial is registered with the International Standard Randomised Controlled Trial Number Register , number ISRCTN@ , and the Deutsches Register Klinischer Studien , number DRKS@ .", "sentence_id": 9}
+{"abstract_id": "24439238", "label": "results", "text": "Between Feb @ , @ , to April @ , @ , we screened @ patients for eligibility , @ of whom we randomly allocated to treatment : @ to IP and @ to DP .", "sentence_id": 10}
+{"abstract_id": "24439238", "label": "results", "text": "DP was non-inferior to IP with respect to the primary outcome , BMI at the @-month follow-up ( mean difference @ kg/m ( @ ) in favour of DP ( @ % CI , -@ to @ ; pnon-inferiority < @ ) .", "sentence_id": 11}
+{"abstract_id": "24439238", "label": "results", "text": "The number of treatment-related serious adverse events was similar in both study groups ( eight in the IP group , seven in the DP group ) .", "sentence_id": 12}
+{"abstract_id": "24439238", "label": "results", "text": "Three serious adverse events in the IP group and two in the DP group were related to suicidal ideation ; one patient in the DP attempted suicide @ months after she was discharged .", "sentence_id": 13}
+{"abstract_id": "24439238", "label": "conclusions", "text": "DP after short inpatient care in adolescent patients with non-chronic anorexia nervosa seems no less effective than IP for weight restoration and maintenance during the first year after admission .", "sentence_id": 14}
+{"abstract_id": "24439238", "label": "conclusions", "text": "Thus , DP might be a safe and less costly alternative to IP .", "sentence_id": 15}
+{"abstract_id": "24439238", "label": "conclusions", "text": "Our results justify the broad implementation of this approach .", "sentence_id": 16}
+{"abstract_id": "25137243", "label": "objective", "text": "Sleep disturbances are common among women in midlife ; prevalence increases among perimenopausal/postmenopausal women with vasomotor symptoms .", "sentence_id": 0}
+{"abstract_id": "25137243", "label": "objective", "text": "Paroxetine @ mg is the only nonhormonal treatment that has been approved in the United States for moderate to severe vasomotor symptoms associated with menopause .", "sentence_id": 1}
+{"abstract_id": "25137243", "label": "objective", "text": "In two pivotal phase @ studies evaluating its efficacy and safety , improvements in sleep disturbances were also prospectively evaluated .", "sentence_id": 2}
+{"abstract_id": "25137243", "label": "methods", "text": "Postmenopausal women with moderate to severe vasomotor symptoms were randomly assigned to paroxetine @ mg ( n = @ ) or placebo ( n = @ ) once daily for @ weeks ( both studies ) or @ weeks ( @-wk study ) .", "sentence_id": 3}
+{"abstract_id": "25137243", "label": "methods", "text": "Predefined assessments on weeks @ , @ , and @ included number of nighttime awakenings attributed to vasomotor symptoms , sleep-onset latency , sleep duration , and sleep-related adverse events .", "sentence_id": 4}
+{"abstract_id": "25137243", "label": "methods", "text": "The two studies ' data for weeks @ to @ were pooled .", "sentence_id": 5}
+{"abstract_id": "25137243", "label": "results", "text": "At baseline , participants reported a mean of @ awakenings/night attributed to vasomotor symptoms .", "sentence_id": 6}
+{"abstract_id": "25137243", "label": "results", "text": "Nighttime awakenings attributed to vasomotor symptoms were significantly reduced within @ weeks of initiating paroxetine @ mg treatment ( @ % reduction vs @ % for placebo ; P = @ ) , and reductions were sustained through @ or @ weeks of treatment .", "sentence_id": 7}
+{"abstract_id": "25137243", "label": "results", "text": "Paroxetine @ mg treatment also significantly increased nighttime sleep duration ( week @ , +@ vs +@ min for placebo ; P = @ ) , but no significant between-group differences in sleep-onset latency or sleep-related adverse events such as sedation were observed .", "sentence_id": 8}
+{"abstract_id": "25137243", "label": "conclusions", "text": "In postmenopausal women treated for menopausal vasomotor symptoms , paroxetine @ mg significantly reduces the number of nighttime awakenings attributed to vasomotor symptoms and increases sleep duration without differentially affecting sleep-onset latency or sedation .", "sentence_id": 9}
+{"abstract_id": "24335055", "label": "background", "text": "The maximal calcium absorption in response to vitamin D has been proposed as a biomarker for vitamin D sufficiency .", "sentence_id": 0}
+{"abstract_id": "24335055", "label": "objective", "text": "The objective was to determine whether there is a threshold beyond which increasing doses of vitamin D , or concentrations of serum @-hydroxyvitamin D -LSB- @ ( OH ) D -RSB- , no longer increase calcium absorption .", "sentence_id": 1}
+{"abstract_id": "24335055", "label": "methods", "text": "This was a placebo-controlled , dose-response , randomized , double-blind study of the effect of vitamin D on calcium absorption in healthy postmenopausal women .", "sentence_id": 2}
+{"abstract_id": "24335055", "label": "methods", "text": "Seventy-six healthy postmenopausal women were randomly assigned to placebo or @ IU ( @ g ) , @ IU ( @ g ) , or @ IU ( @ g ) vitamin D for @ wk .", "sentence_id": 3}
+{"abstract_id": "24335055", "label": "methods", "text": "The technique of dual isotopes of stable calcium was used with a calcium carrier to measure calcium absorption at baseline and after @ wk .", "sentence_id": 4}
+{"abstract_id": "24335055", "label": "results", "text": "Seventy-one women with a mean SD age of @ @ y completed the study .", "sentence_id": 5}
+{"abstract_id": "24335055", "label": "results", "text": "The mean calcium intake was @ @ mg/d and serum @ ( OH ) D was @ @ nmol/L at baseline .", "sentence_id": 6}
+{"abstract_id": "24335055", "label": "results", "text": "A statistically significant linear trend of an increase in calcium absorption adjusted for age and body mass index with increasing vitamin D dose or serum @ ( OH ) D concentration was observed .", "sentence_id": 7}
+{"abstract_id": "24335055", "label": "results", "text": "A @ % absolute increase in calcium absorption was found in the highest vitamin D group ( @ g ) .", "sentence_id": 8}
+{"abstract_id": "24335055", "label": "results", "text": "No evidence of nonlinearity was observed in the dose-response curve .", "sentence_id": 9}
+{"abstract_id": "24335055", "label": "conclusions", "text": "No evidence of a threshold of calcium absorption was found with a serum @ ( OH ) D range from @ to @ nmol/L .", "sentence_id": 10}
+{"abstract_id": "24335055", "label": "conclusions", "text": "Calcium absorption in this range is not a useful biomarker to determine nutritional recommendations for vitamin D.", "sentence_id": 11}
+{"abstract_id": "24274190", "label": "background", "text": "In the paediatric population , pain and distress associated with burn injuries during wound care procedures remain a constant challenge .", "sentence_id": 0}
+{"abstract_id": "24274190", "label": "background", "text": "Although silver dressings are the gold standard for burn care in Australasia , very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically .", "sentence_id": 1}
+{"abstract_id": "24274190", "label": "background", "text": "Therefore , for paediatric patients in particular , identifying silver dressings that are associated with lower levels of pain and rapid wound re-epithelialisation is imperative .", "sentence_id": 2}
+{"abstract_id": "24274190", "label": "background", "text": "This study will determine whether there is a difference in time to re-epithelialisation and pain and distress experienced during wound care procedures among Acticoat , Acticoat combined with Mepitel and Mepilex Ag dressings for acute , paediatric partial thickness burns .", "sentence_id": 3}
+{"abstract_id": "24274190", "label": "methods", "text": "Children aged @ to @ years with an acute partial thickness ( superficial partial to deep partial thickness inclusive ) burn injury and a burn total body surface area of @ % will be eligible for the trial .", "sentence_id": 4}
+{"abstract_id": "24274190", "label": "methods", "text": "Patients will be randomised to one of the three dressing groups : ( @ ) Acticoat or ( @ ) Acticoat combined with Mepitel or ( @ ) Mepilex Ag .", "sentence_id": 5}
+{"abstract_id": "24274190", "label": "methods", "text": "A minimum of @ participants will be recruited for each treatment group .", "sentence_id": 6}
+{"abstract_id": "24274190", "label": "methods", "text": "Primary measures of pain , distress and healing will be repeated at each dressing change until complete wound re-epithelialisation occurs or skin grafting is required .", "sentence_id": 7}
+{"abstract_id": "24274190", "label": "methods", "text": "Additional data collected will include infection status at each dressing change , physical function , scar outcome and scar management requirements , cost effectiveness of each dressing and staff perspectives of the dressings .", "sentence_id": 8}
+{"abstract_id": "24274190", "label": "conclusions", "text": "The results of this study will determine the effects of three commonly used silver and silicone burn dressing combinations on the rate of wound re-epithelialisation and pain experienced during dressing procedures in acute , paediatric partial thickness burn injuries .", "sentence_id": 9}
+{"abstract_id": "24955739", "label": "objective", "text": "To evaluate the efficacy of valproic acid ( VPA ) on visual function in patients with retinitis pigmentosa ( RP ) .", "sentence_id": 0}
+{"abstract_id": "24955739", "label": "methods", "text": "Thirty patients ( @ eyes ) with typical RP were recruited for the study .", "sentence_id": 1}
+{"abstract_id": "24955739", "label": "methods", "text": "Of these , @ patients received oral VPA ( @mg once daily ) for a period of @ year ( group @ ) and the remaining @ received no treatment ( group @ ) and served as controls .", "sentence_id": 2}
+{"abstract_id": "24955739", "label": "methods", "text": "The effect of VPA on visual function was determined in terms of visual acuity , amplitude and implicit time in multifocal electroretinography ( mfERG ) , and visual evoked response ( VER ) performed at presentation and at the third month , sixth month , and @ year in both groups .", "sentence_id": 3}
+{"abstract_id": "24955739", "label": "methods", "text": "Side effects of oral VPA were also monitored .", "sentence_id": 4}
+{"abstract_id": "24955739", "label": "results", "text": "At @-year follow-up , @ of @ patients in group @ had improvement in median best corrected visual acuity ( BCVA ) from @ -LSB- Range ( R ) @-@ -RSB- at baseline to @ ( R , @-@ @ ) ( P < @ ) .", "sentence_id": 5}
+{"abstract_id": "24955739", "label": "results", "text": "In contrast , there was a slight decrease in median BCVA from @ ( @ - @ ) logarithm of the minimum angle of resolution ( logMAR ) at baseline to @ ( P = @ ) in the control arm .", "sentence_id": 6}
+{"abstract_id": "24955739", "label": "results", "text": "There was also a statistically significant increase in improvement in amplitude and latency/implicit time in mfERG and VER in this group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24955739", "label": "results", "text": "However , no such improvement was observed in the control arm .", "sentence_id": 8}
+{"abstract_id": "24955739", "label": "conclusions", "text": "Thus , VPA seems to have a positive effect on the visual functions in RP patients .", "sentence_id": 9}
+{"abstract_id": "24955739", "label": "conclusions", "text": "Long-term studies evaluating the dose modifications , genetic analysis , and change in visual fields will add to our current knowledge .", "sentence_id": 10}
+{"abstract_id": "24748778", "label": "objective", "text": "Delirium is associated with poor outcomes following acute hospitalization .", "sentence_id": 0}
+{"abstract_id": "24748778", "label": "objective", "text": "The Geriatric Monitoring Unit ( GMU ) is a specialized five-bedded unit for acute delirium care .", "sentence_id": 1}
+{"abstract_id": "24748778", "label": "objective", "text": "It is modeled after the Delirium Room program , with adoption of core interventions from the Hospital Elder Life Program and use of evening light therapy to consolidate circadian rhythms and improve sleep in older inpatients .", "sentence_id": 2}
+{"abstract_id": "24748778", "label": "objective", "text": "This study examined whether the GMU program improved outcomes in delirious patients .", "sentence_id": 3}
+{"abstract_id": "24748778", "label": "methods", "text": "A total of @ patients , including @ pre-GMU , @ GMU , and @ concurrent control subjects , were studied .", "sentence_id": 4}
+{"abstract_id": "24748778", "label": "methods", "text": "Clinical characteristics , cognitive status , functional status ( Modified Barthel Index -LSB- MBI -RSB- ) , and chemical restraint-use data were obtained .", "sentence_id": 5}
+{"abstract_id": "24748778", "label": "methods", "text": "We also looked at in-hospital complications of falls , pressure ulcers , nosocomial infection rate , and discharge destination .", "sentence_id": 6}
+{"abstract_id": "24748778", "label": "methods", "text": "Secondary outcomes of family satisfaction ( for the GMU subjects ) were collected .", "sentence_id": 7}
+{"abstract_id": "24748778", "label": "results", "text": "There were no significant demographic differences between the three groups .", "sentence_id": 8}
+{"abstract_id": "24748778", "label": "results", "text": "Pre-GMU subjects had longer duration of delirium and length of stay .", "sentence_id": 9}
+{"abstract_id": "24748778", "label": "results", "text": "MBI improvement was most evident in the GMU compared with pre-GMU and control subjects ( @ , @ , @ , respectively ) ( P < @ ) .", "sentence_id": 10}
+{"abstract_id": "24748778", "label": "results", "text": "The GMU subjects had a zero restraint rate , and pre-GMU subjects had higher antipsychotic dosages .", "sentence_id": 11}
+{"abstract_id": "24748778", "label": "results", "text": "This translated to lower pressure ulcer and nosocomial infection rate in the GMU ( @ % and @ % , respectively ) and control ( @ % and @ % , respectively ) subjects compared with the pre-GMU ( @ % and @ % , respectively ) subjects ( P < @ ) .", "sentence_id": 12}
+{"abstract_id": "24748778", "label": "results", "text": "No differences were observed in mortality or discharge destination among the three groups .", "sentence_id": 13}
+{"abstract_id": "24748778", "label": "results", "text": "Caregivers of GMU subjects felt the multicomponent intervention to be useful , with scheduled activities voted the most beneficial in patient 's recovery from the delirium episode .", "sentence_id": 14}
+{"abstract_id": "24748778", "label": "conclusions", "text": "This study shows the benefits of a specialized delirium management unit for older persons .", "sentence_id": 15}
+{"abstract_id": "24748778", "label": "conclusions", "text": "The GMU model is thus a relevant system of care for rapidly `` graying '' nations with high rates of frail elderly hospital admissions , which can be easily transposed across acute care settings .", "sentence_id": 16}
+{"abstract_id": "24820498", "label": "objective", "text": "To study the value of contrast-enhanced ultrasound in tuberculous cervical lymph node biopsy .", "sentence_id": 0}
+{"abstract_id": "24820498", "label": "methods", "text": "Seventy-nine patients with cervical lymph node were divided into two groups .", "sentence_id": 1}
+{"abstract_id": "24820498", "label": "methods", "text": "The lymph nodes of group A were used as real-time ultrasound guided biopsy ; the lymph nodes of group B were contrast-enhanced ultrasound firstly to determine the target lymph node and the puncture point , then were detected with needle biopsy .", "sentence_id": 2}
+{"abstract_id": "24820498", "label": "results", "text": "Group A : for the @ lymph nodes of @ patients , the rate of intact tissue was @ % and the positive rate of pathological diagnosis was @ % .", "sentence_id": 3}
+{"abstract_id": "24820498", "label": "results", "text": "Group B : for the @ lymph nodes of @ patients , the rate of intact tissue was @ % and the positive rate of pathological diagnosis was @ % ( Chi square value was @ and @ , P < @ ) .", "sentence_id": 4}
+{"abstract_id": "24820498", "label": "conclusions", "text": "The application of contrast-enhanced ultrasound before cervical lymph node biopsy can obviously improve the rate of intact tissue and the positive rate of pathological diagnosis .", "sentence_id": 5}
+{"abstract_id": "24490058", "label": "background", "text": "Few safe and effective dietary supplements are available to promote weight loss .", "sentence_id": 0}
+{"abstract_id": "24490058", "label": "background", "text": "We evaluated the safety and efficacy of glucomannan , a water-soluble fiber supplement , for achieving weight loss in overweight and moderately obese individuals consuming self-selected diets .", "sentence_id": 1}
+{"abstract_id": "24490058", "label": "methods", "text": "Participants were randomly assigned to take @ grams of glucomannan or identically looking placebo capsules with @ mL ( @ ounces ) of water one hour before breakfast , lunch , and dinner for @ weeks .", "sentence_id": 2}
+{"abstract_id": "24490058", "label": "methods", "text": "The primary efficacy outcome was change in body weight after @ weeks .", "sentence_id": 3}
+{"abstract_id": "24490058", "label": "methods", "text": "Other efficacy outcomes were changes in body composition , hunger/fullness , and lipid and glucose concentrations .", "sentence_id": 4}
+{"abstract_id": "24490058", "label": "methods", "text": "Safety outcomes included gastrointestinal symptoms/tolerance and serum liver enzymes and creatinine levels .", "sentence_id": 5}
+{"abstract_id": "24490058", "label": "results", "text": "A total of @ participants ( @-@ years of age ; BMI @-@kg / m ) were enrolled and randomized .", "sentence_id": 6}
+{"abstract_id": "24490058", "label": "results", "text": "The two groups did not differ with respect to baseline characteristics and compliance with the study supplement .", "sentence_id": 7}
+{"abstract_id": "24490058", "label": "results", "text": "At @ weeks , there was no significant difference between the glucomannan and placebo groups in amount of weight loss ( -@ @ and -@ @ , resp . )", "sentence_id": 8}
+{"abstract_id": "24490058", "label": "results", "text": "or other efficacy outcomes or in any of the safety outcomes .", "sentence_id": 9}
+{"abstract_id": "24490058", "label": "conclusions", "text": "Glucomannan supplements administered over @ weeks were well tolerated but did not promote weight loss or significantly alter body composition , hunger/fullness , or lipid and glucose parameters .", "sentence_id": 10}
+{"abstract_id": "24490058", "label": "conclusions", "text": "This trial is registered with NCT@ .", "sentence_id": 11}
+{"abstract_id": "25125001", "label": "objective", "text": "To assess daily functioning and geriatric conditions of older subjects suffering from heart failure ( HF ) as compared to the general population .", "sentence_id": 0}
+{"abstract_id": "25125001", "label": "results", "text": "The data were collected as part of the nationwide PolSenior project ( @-@ ) .", "sentence_id": 1}
+{"abstract_id": "25125001", "label": "results", "text": "Of @ individuals ( age range @-@ years ) , data on self-reported HF hospitalization were available for @ subjects ( @ % ) .", "sentence_id": 2}
+{"abstract_id": "25125001", "label": "results", "text": "Geriatric assessment ( GA ) included functional status ( ADL , Activities of Daily Living and IADL , Instrumental ADL scales ) , cognitive function , mood disorders , sensory organ impairment , falls and comorbidity .", "sentence_id": 3}
+{"abstract_id": "25125001", "label": "results", "text": "Mean age SD of the study population was @ @ years ; @ % were female .", "sentence_id": 4}
+{"abstract_id": "25125001", "label": "results", "text": "The proportion of subjects with HF hospitalizations increased from @ % in subjects aged @-@ years up to @ % in the age group of @-@ years , and decreased in nonagenarians ( @ % ) .", "sentence_id": 5}
+{"abstract_id": "25125001", "label": "results", "text": "Subjects with the HF hospitalization were older , used more drugs , and were characterized by a higher prevalence of comorbid conditions , mood disorders , hearing impairment and functional limitations .", "sentence_id": 6}
+{"abstract_id": "25125001", "label": "results", "text": "In logistic regression , HF hospitalization increased the age-sex adjusted risk of disability by @ % , both in ADL and IADL .", "sentence_id": 7}
+{"abstract_id": "25125001", "label": "results", "text": "After adjustment to other clinical and geriatric conditions , HF hospitalization remained an independent predictor of disability in both ADL ( OR = @ , @ % CI : @-@ @ ) and IADL ( OR = @ , @ % CI : @-@ @ ) .", "sentence_id": 8}
+{"abstract_id": "25125001", "label": "conclusions", "text": "Older people who reported HF admissions had a higher number of comorbidities and geriatric conditions : mood disorders , hearing impairment and functional limitations .", "sentence_id": 9}
+{"abstract_id": "25125001", "label": "conclusions", "text": "Besides , in our study , HF hospitalization independently and significantly increased the risk of limitations in IADL and ADL .", "sentence_id": 10}
+{"abstract_id": "25125001", "label": "conclusions", "text": "Therefore , further studies are needed to evaluate the benefits of GA in patients with HF .", "sentence_id": 11}
+{"abstract_id": "24893655", "label": "background", "text": "The course of swine influenza in pigs is reported to be similar to human influenza .", "sentence_id": 0}
+{"abstract_id": "24893655", "label": "background", "text": "Occasionally abortions and other reproduction disorders have been associated with influenza A virus ( IAV ) infection in pigs .", "sentence_id": 1}
+{"abstract_id": "24893655", "label": "background", "text": "Abortions may be a consequence of high fever , pro-inflammatory cytokines or transplacental transmission of the virus.The role of IAV in the complications observed during pregnancy has been scanty and the true importance of this agent as a cause of reproductive problems in swine is not known .", "sentence_id": 2}
+{"abstract_id": "24893655", "label": "background", "text": "The aim was to determine the possible involvement of swine H@N@ IAV strain on reproductive disorders in pregnant gilts under experimental conditions .", "sentence_id": 3}
+{"abstract_id": "24893655", "label": "results", "text": "The gestation length was from @ to @ days , no abortion or any other reproduction disorders were noted .", "sentence_id": 4}
+{"abstract_id": "24893655", "label": "results", "text": "A PCR assay confirms the presence of IAV in the nasal swabs taken from inoculated gilts between @ and @ dpi .", "sentence_id": 5}
+{"abstract_id": "24893655", "label": "results", "text": "In the nasal swabs from control gilts and newborn piglets , no IAV genetic material was found .", "sentence_id": 6}
+{"abstract_id": "24893655", "label": "results", "text": "No viral RNA was detected in samples of blood taken from gilts and piglets , placentas , lungs and tracheas taken from piglets euthanized after delivery .", "sentence_id": 7}
+{"abstract_id": "24893655", "label": "results", "text": "The significant decrease in the number and percentage of lymphocytes without leukopenia was observed at @ dpi in inoculated gilts .", "sentence_id": 8}
+{"abstract_id": "24893655", "label": "results", "text": "The percentage of granulocytes increased significantly at @ dpi in inoculated pigs .", "sentence_id": 9}
+{"abstract_id": "24893655", "label": "results", "text": "The concentration of IL-@ , IL-@ and TNF - were higher in inoculated gilts , while IL-@ and IFN - were not detected in the serum of any of animals .", "sentence_id": 10}
+{"abstract_id": "24893655", "label": "results", "text": "The serum concentrations of C-reactive protein remained stable during study , while haptoglobin concentrations increased significantly after inoculation .", "sentence_id": 11}
+{"abstract_id": "24893655", "label": "conclusions", "text": "The results of the study indicate that infection of pregnant gilts with swine H@N@ IAV in the second month of pregnancy does not cause abortion and other reproduction disorders .", "sentence_id": 12}
+{"abstract_id": "24893655", "label": "conclusions", "text": "No evidence for transplacental transmission of swine H@N@ IAV was found .", "sentence_id": 13}
+{"abstract_id": "24893655", "label": "conclusions", "text": "However , due to subclinical course of influenza in the present experiment caution should be taken in extrapolating these results to the cases of acute influenza .", "sentence_id": 14}
+{"abstract_id": "24893655", "label": "conclusions", "text": "The other limitation is IAV diversity .", "sentence_id": 15}
+{"abstract_id": "24893655", "label": "conclusions", "text": "It can not be excluded that other subtypes of IAV could be associated to reproduction failure in pigs .", "sentence_id": 16}
+{"abstract_id": "25875131", "label": "objective", "text": "Although applying adhesive strips to a wound closure has been shown to have outcomes equivalent to those with cuticular suturing , it is unknown whether adhesive strips provide additional benefit compared with dermal suturing alone .", "sentence_id": 0}
+{"abstract_id": "25875131", "label": "objective", "text": "To determine whether the addition of adhesive strips to a wound closed with buried interrupted subcuticular sutures improves outcomes following wound closure .", "sentence_id": 1}
+{"abstract_id": "25875131", "label": "methods", "text": "A prospective , randomized split-wound intervention was conducted between November @ , @ , and May @ , @ , in patients who underwent cutaneous surgical procedures at the University of California , Davis , outpatient dermatology clinic .", "sentence_id": 2}
+{"abstract_id": "25875131", "label": "methods", "text": "Fifty-seven patients @ years or older with postoperative defects of at least @ cm , resulting from either Mohs micrographic surgical procedures or surgical excision , were screened for participation .", "sentence_id": 3}
+{"abstract_id": "25875131", "label": "methods", "text": "Nine patients were excluded and @ were enrolled .", "sentence_id": 4}
+{"abstract_id": "25875131", "label": "methods", "text": "Half of each wound was randomized to receive buried interrupted subcuticular sutures and overlying adhesive strips and the other half received buried interrupted subcuticular sutures only .", "sentence_id": 5}
+{"abstract_id": "25875131", "label": "methods", "text": "At @ months ' follow-up , each patient and @ blinded observers evaluated the wound using the Patient Observer Scar Assessment Scale .", "sentence_id": 6}
+{"abstract_id": "25875131", "label": "results", "text": "The total mean ( SD ) Patient Observer Scar Assessment Scale score for observers for the side that received a combination of adhesive strips and buried interrupted subcuticular suturing ( @ -LSB- @ -RSB- ) and the side that received sutures only ( @ -LSB- @ -RSB- ) did not differ significantly at @ months ( P = @ ) .", "sentence_id": 7}
+{"abstract_id": "25875131", "label": "results", "text": "There was no significant difference in the total patient assessment scale score between the combination closure ( @ -LSB- @ -RSB- ) and sutures only ( @ -LSB- @ -RSB- ) sides at @ months ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25875131", "label": "results", "text": "There was also no significant difference between the @ closure methods in terms of mean ( SD ) scar width ( both methods : @ -LSB- @ -RSB- mm , P = @ ) at follow-up .", "sentence_id": 9}
+{"abstract_id": "25875131", "label": "conclusions", "text": "Combination closure with adhesive strips and buried interrupted subcuticular suturing was not significantly associated with improved overall scar assessment compared with buried interrupted subcuticular suturing alone when evaluated by blinded observers or the patients themselves .", "sentence_id": 10}
+{"abstract_id": "25875131", "label": "conclusions", "text": "Our results do not support the use of adhesive strips as a means to improve cosmetic outcomes or reduce scar width .", "sentence_id": 11}
+{"abstract_id": "25592014", "label": "objective", "text": "The aim of this study was to determine the effect of plant-based diets on weight loss .", "sentence_id": 0}
+{"abstract_id": "25592014", "label": "methods", "text": "Participants were enrolled in a @-mo , five-arm , randomized controlled trial in @ in South Carolina .", "sentence_id": 1}
+{"abstract_id": "25592014", "label": "methods", "text": "Participants attended weekly group meetings , with the exception of the omnivorous group , which served as the control and attended monthly meetings augmented with weekly e-mail lessons .", "sentence_id": 2}
+{"abstract_id": "25592014", "label": "methods", "text": "All groups attended monthly meetings for the last @ mo of the study .", "sentence_id": 3}
+{"abstract_id": "25592014", "label": "methods", "text": "Diets did not emphasize caloric restriction .", "sentence_id": 4}
+{"abstract_id": "25592014", "label": "results", "text": "Overweight adults ( body mass index @-@ @ kg/m ( @ ) ; age @-@ y , @ % non-white , and @ % men ) were randomized to a low-fat , low-glycemic index diet : vegan ( n = @ ) , vegetarian ( n = @ ) , pesco-vegetarian ( n = @ ) , semi-vegetarian ( n = @ ) , or omnivorous ( n = @ ) .", "sentence_id": 5}
+{"abstract_id": "25592014", "label": "results", "text": "Fifty ( @ % ) participants completed the study .", "sentence_id": 6}
+{"abstract_id": "25592014", "label": "results", "text": "In intention-to-treat analysis , the linear trend for weight loss across the five groups was significant at both @ ( P < @ ) and @ mo ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25592014", "label": "results", "text": "At @ mo , the weight loss in the vegan group ( -@ % @ % ) was significantly different from the omnivorous ( -@ % @ % ; P = @ ) , semi-vegetarian ( -@ % @ % ; P = @ ) , and pesco-vegetarian ( -@ % @ % ; P = @ ) groups .", "sentence_id": 8}
+{"abstract_id": "25592014", "label": "results", "text": "Vegan participants decreased their fat and saturated fat more than the pesco-vegetarian , semi-vegetarian , and omnivorous groups at both @ and @ mo ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25592014", "label": "conclusions", "text": "Vegan diets may result in greater weight loss than more modest recommendations .", "sentence_id": 10}
+{"abstract_id": "26059337", "label": "objective", "text": "To assess the safety and efficacy of pitavastatin in children and adolescents with hyperlipidemia .", "sentence_id": 0}
+{"abstract_id": "26059337", "label": "methods", "text": "A total of @ children and adolescents with hyperlipidemia , ages @ to @ years , were enrolled in a @-week randomized , double-blind , placebo-controlled study and randomly assigned to pitavastatin @ mg , @ mg , @ mg , or placebo .", "sentence_id": 1}
+{"abstract_id": "26059337", "label": "methods", "text": "During a @-week extension period , subjects were up-titrated from @ mg pitavastatin to a maximum dose of @ mg in an effort to achieve an optimum low-density lipoprotein cholesterol ( LDL-C ) treatment target of < @ mg/dL ( @ mmol/L ) .", "sentence_id": 2}
+{"abstract_id": "26059337", "label": "methods", "text": "Adverse events rates , including abnormal clinical laboratory variables , vital signs , and physical examination were assessed .", "sentence_id": 3}
+{"abstract_id": "26059337", "label": "results", "text": "Compared with placebo , pitavastatin @ , @ , and @ mg significantly reduced LDL-C from baseline by @ % , @ % , and @ % , respectively , and in the open-label study @ % of the subjects reached the LDL-C goal < @ mg/dL ( @ mmol/L ) .", "sentence_id": 4}
+{"abstract_id": "26059337", "label": "results", "text": "No safety issues were evident .", "sentence_id": 5}
+{"abstract_id": "26059337", "label": "conclusions", "text": "Pitavastatin at doses up to @ mg is well tolerated and efficacious in children and adolescents aged @-@ years .", "sentence_id": 6}
+{"abstract_id": "24633376", "label": "objective", "text": "Speech perception is the most important social task of the auditory system .", "sentence_id": 0}
+{"abstract_id": "24633376", "label": "objective", "text": "Consequently , speech audiometry is essential to evaluate hearing aid benefit .", "sentence_id": 1}
+{"abstract_id": "24633376", "label": "objective", "text": "The aim of the study was to describe the correlation between pure-tone hearing loss and speech perception .", "sentence_id": 2}
+{"abstract_id": "24633376", "label": "objective", "text": "In particular , pure-tone audiogram , speech audiogram , and speech perception with hearing aids were compared .", "sentence_id": 3}
+{"abstract_id": "24633376", "label": "methods", "text": "In a retrospective study , @ hearing aid users with bilateral sensorineural hearing loss were included .", "sentence_id": 4}
+{"abstract_id": "24633376", "label": "methods", "text": "Pure-tone loss ( PTA ) was correlated to monosyllabic perception at @ dB with hearing aid and with maximum monosyllabic perception with headphones .", "sentence_id": 5}
+{"abstract_id": "24633376", "label": "results", "text": "Speech perception as a function of hearing loss can be represented by a sigmoid function .", "sentence_id": 6}
+{"abstract_id": "24633376", "label": "results", "text": "However , for higher degrees of hearing loss , substantial deviations are observed .", "sentence_id": 7}
+{"abstract_id": "24633376", "label": "results", "text": "Maximum monosyllabic perception with headphones is usually not achieved with hearing aids at standard speech levels of @ dB .", "sentence_id": 8}
+{"abstract_id": "24633376", "label": "conclusions", "text": "For larger groups , average pure-tone hearing loss and speech perception correlate significantly .", "sentence_id": 9}
+{"abstract_id": "24633376", "label": "conclusions", "text": "However , prognosis for individuals is not possible .", "sentence_id": 10}
+{"abstract_id": "24633376", "label": "conclusions", "text": "In particular for higher degrees of hearing loss substantial deviations could be observed .", "sentence_id": 11}
+{"abstract_id": "24633376", "label": "conclusions", "text": "Speech performance with hearing aids can not be predicted sufficiently from speech audiograms .", "sentence_id": 12}
+{"abstract_id": "24633376", "label": "conclusions", "text": "Above the age of @ , speech perception is significantly worse .", "sentence_id": 13}
+{"abstract_id": "24655978", "label": "background", "text": "Hyperlipidemia occurs in up to @ % of kidney transplant ( KT ) recipients who take everolimus ( EVL ) .", "sentence_id": 0}
+{"abstract_id": "24655978", "label": "background", "text": "As a result of this , statins are the most commonly prescribed lipid-lowering drugs among these patients .", "sentence_id": 1}
+{"abstract_id": "24655978", "label": "background", "text": "However , we are concerned whether there are any drug interactions between EVL and statins , because both of these drugs use the same pharmacokinetics pathway .", "sentence_id": 2}
+{"abstract_id": "24655978", "label": "background", "text": "Therefore , we assessed the effects of concomitant use of EVL and atorvastatin .", "sentence_id": 3}
+{"abstract_id": "24655978", "label": "methods", "text": "In this randomized , open-label , crossover study , @ KT patients were assigned ( @:@ ) to receive EVL with or without @ mg atorvastatin for @ month .", "sentence_id": 4}
+{"abstract_id": "24655978", "label": "methods", "text": "One-month washout period was used before crossover .", "sentence_id": 5}
+{"abstract_id": "24655978", "label": "methods", "text": "Plasma EVL concentrations were measured by homogeneous particle-enhanced turbidimetric immunoassay .", "sentence_id": 6}
+{"abstract_id": "24655978", "label": "methods", "text": "Twelve-hour area under the time-concentration curve ( AUC@-@ ) of EVL was calculated with the use of whole-blood EVL concentrations from @ different time points ( @ , @ , @ , @ , @ , @ , @ , @ , @ , and @ hours ) .", "sentence_id": 7}
+{"abstract_id": "24655978", "label": "results", "text": "The mean ( SD ) AUC@-@ for EVL and EVL plus atorvastatin was @ ( @ ) ngh/mL and @ ( @ ) ngh/mL , respectively ( P > @ ; paired t test ) .", "sentence_id": 8}
+{"abstract_id": "24655978", "label": "results", "text": "No difference of EVL Cmax or Tmax was found after atorvastatin coadministration .", "sentence_id": 9}
+{"abstract_id": "24655978", "label": "results", "text": "Even though the EVL AUC@-@ levels were not affected by atorvastatin coadministration in one-half of the subjects , for the rest of the patients , there were unpredictable changes in the EVL AUC@-@ levels .", "sentence_id": 10}
+{"abstract_id": "24655978", "label": "results", "text": "This may be due to the high intrapatient variability of EVL drug concentration ( coefficient of variation ranges from @ % to @ % ) .", "sentence_id": 11}
+{"abstract_id": "24655978", "label": "conclusions", "text": "Coadministration of atorvastatin with EVL in KT recipients did not affect the pharmacokinetics of EVL .", "sentence_id": 12}
+{"abstract_id": "24289490", "label": "background", "text": "Problem-based learning ( PBL ) involves discussions among students who resolve loosely-structured problems to facilitate learning .", "sentence_id": 0}
+{"abstract_id": "24289490", "label": "background", "text": "In the PBL curriculum , faculty tutors are employed as facilitators for small groups of students .", "sentence_id": 1}
+{"abstract_id": "24289490", "label": "background", "text": "Because of lack of time and staff shortage , the effectiveness of tutorless PBL has been discussed as an alternate option .", "sentence_id": 2}
+{"abstract_id": "24289490", "label": "methods", "text": "Sessions in which tutored and tutorless PBL groups are mixed were presented by @st-year medical students , who experienced both tutored and tutorless groups alternately in the two sessions of a year .", "sentence_id": 3}
+{"abstract_id": "24289490", "label": "methods", "text": "To examine the effectiveness of tutored and tutorless PBL , written examination scores ( WES ) and self-contentment scores ( SCS ) were statistically analysed .", "sentence_id": 4}
+{"abstract_id": "24289490", "label": "results", "text": "WES averages did not significantly differ between the tutored and tutorless groups ; however , a significantly greater variation was observed in WES in the tutorless group .", "sentence_id": 5}
+{"abstract_id": "24289490", "label": "results", "text": "SCS averages tended to be higher in the tutored PBL than in tutorless PBL groups .", "sentence_id": 6}
+{"abstract_id": "24289490", "label": "conclusions", "text": "Students in these tutorless PBL groups performed well in their written examinations , whereas those in the tutored PBL groups , achieved this and reported better self-contentment with their learning experience .", "sentence_id": 7}
+{"abstract_id": "24289490", "label": "conclusions", "text": "Tutorless PBL sessions were considered to be comparable to tutored PBL sessions at least in the early stages .", "sentence_id": 8}
+{"abstract_id": "24891007", "label": "methods", "text": "Randomised , double-blind , placebo-controlled crossover trial of melatonin supplementation to people with complete tetraplegia .", "sentence_id": 0}
+{"abstract_id": "24891007", "label": "objective", "text": "To investigate the effect that @mg melatonin supplementation has on objective and subjective sleep , quality of life and mood of people living with complete tetraplegia .", "sentence_id": 1}
+{"abstract_id": "24891007", "label": "methods", "text": "Austin Hospital Sleep Laboratory and participants ' homes , Melbourne , Victoria , Australia .", "sentence_id": 2}
+{"abstract_id": "24891007", "label": "methods", "text": "Two week run-in followed by @ week nightly administration of @mg melatonin or placebo , @-week washout and further @ week administration of the opposite treatment .", "sentence_id": 3}
+{"abstract_id": "24891007", "label": "methods", "text": "Four testing sessions were conducted ; the last nights of the run-in , treatment and washout periods .", "sentence_id": 4}
+{"abstract_id": "24891007", "label": "methods", "text": "Testing sessions involved recording full polysomnography , completing a questionnaire battery and collecting urine and blood samples .", "sentence_id": 5}
+{"abstract_id": "24891007", "label": "methods", "text": "The questionnaires assessed mood , sleep symptoms and health-related quality of life , and the urine and plasma samples assayed @-sulphatoxymelatonin ( aMT@s ) and melatonin levels , respectively .", "sentence_id": 6}
+{"abstract_id": "24891007", "label": "methods", "text": "A sleep diary was completed throughout the study .", "sentence_id": 7}
+{"abstract_id": "24891007", "label": "results", "text": "Eight participants ( mean ( s.d. ) : age @ years ( @ ) , postinjury @ years ( @ ) ) were recruited in which seven concluded the protocol .", "sentence_id": 8}
+{"abstract_id": "24891007", "label": "results", "text": "Endogenous-circulating melatonin was significantly higher ( P < or = @ ) following melatonin ( urine : @ gh ( -@ ) ( @ ) , plasma : @,@ pM ( @,@ ) ) than placebo ( urine : @ gh ( -@ ) ( @ ) , plasma : @ pM ( @ ) ) .", "sentence_id": 9}
+{"abstract_id": "24891007", "label": "results", "text": "Subjective sleep improved significantly following melatonin specifically for duration of sleep per night and psychological wellbeing .", "sentence_id": 10}
+{"abstract_id": "24891007", "label": "results", "text": "Objective sleep showed a significant increase in light sleep with melatonin , with all other sleep parameters being unchanged .", "sentence_id": 11}
+{"abstract_id": "24891007", "label": "conclusions", "text": "These results suggest that increasing melatonin in people with complete tetraplegia is beneficial , especially for subjective sleep .", "sentence_id": 12}
+{"abstract_id": "24891007", "label": "conclusions", "text": "Investigation of the pharmacokinetics of melatonin metabolism in this population is warranted .", "sentence_id": 13}
+{"abstract_id": "25926408", "label": "background", "text": "Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses .", "sentence_id": 0}
+{"abstract_id": "25926408", "label": "objective", "text": "We tested the hypotheses that gastrointestinal physiologic responses and satiety will be increased by an increase in intragastric stability and by a decrease in fat droplet size of a fat emulsion .", "sentence_id": 1}
+{"abstract_id": "25926408", "label": "methods", "text": "This was a double-blind , randomized crossover study in @ healthy persons -LSB- @ men and @ women , aged @ @ y ; body mass index ( in kg/m ( @ ) ) : @ @ -RSB- who consumed meals containing @-g @ % oil and water emulsion ( @ kJ ) with @ ) larger , @-m mean droplet size ( Coarse treatment ) expected to cream in the stomach ; @ ) larger , @-m mean droplet size with @ % locust bean gum ( LBG ; Coarse + LBG treatment ) to prevent creaming ; or @ ) smaller , @-m mean droplet size with LBG ( Fine + LBG treatment ) .", "sentence_id": 2}
+{"abstract_id": "25926408", "label": "methods", "text": "The participants were imaged hourly by using MRI and food intake was assessed by using a meal that participants consumed ad libitum .", "sentence_id": 3}
+{"abstract_id": "25926408", "label": "results", "text": "The Coarse + LBG treatment ( preventing creaming in the stomach ) slowed gastric emptying , resulting in @ % higher gastric volume over time ( P < @ ) , increased small bowel water content ( SBWC ) by @ % ( P < @ ) , slowed appearance of the ( @ ) C label in the breath by @ % ( P < @ ) , and reduced food intake by @ % ( P < @ ) compared with the Coarse treatment .", "sentence_id": 4}
+{"abstract_id": "25926408", "label": "results", "text": "The Fine + LBG treatment ( smaller droplet size ) slowed gastric emptying , resulting in @ % higher gastric volume ( P < @ ) , increased SBWC content by @ % ( P < @ ) , and significantly reduced food intake by @ % ( P < @ , equivalent to an average of @ kJ less energy consumed ) compared with the Coarse + LBG treatment .", "sentence_id": 5}
+{"abstract_id": "25926408", "label": "results", "text": "These high-fat meals stimulated substantial increases in SBWC , which increased to a peak at @ h at @ mL ( range : @-@ mL ; P < @ ) for the Fine + LBG treatment .", "sentence_id": 6}
+{"abstract_id": "25926408", "label": "conclusions", "text": "Manipulating intragastric stability and fat emulsion droplet size can influence human gastrointestinal physiology and food intake .", "sentence_id": 7}
+{"abstract_id": "24622120", "label": "objective", "text": "This analysis aimed to perform a head-to-head comparison of @ of the promising biomarkers of cardiovascular ( CV ) outcomes in heart failure ( HF ) - soluble ST@ ( sST@ ) , growth differentiation factor ( GDF ) -@ , and highly-sensitive troponin T ( hsTnT ) - and to evaluate the role of serial measurement of these biomarkers in patients with chronic HF .", "sentence_id": 0}
+{"abstract_id": "24622120", "label": "background", "text": "sST@ , GDF-@ , and hsTnT are strongly associated with CV outcomes in HF .", "sentence_id": 1}
+{"abstract_id": "24622120", "label": "methods", "text": "This post-hoc analysis used data from a study in which @ patients with chronic HF due to left ventricular systolic dysfunction were followed up over @ months .", "sentence_id": 2}
+{"abstract_id": "24622120", "label": "methods", "text": "At each visit , N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) , sST@ , GDF-@ , and hsTnT were measured and any major CV events were recorded .", "sentence_id": 3}
+{"abstract_id": "24622120", "label": "results", "text": "Baseline values of all @ novel biomarkers independently predicted total CV events even after adjusting for clinical and biochemical characteristics , including NT-proBNP , with the best model including all @ biomarkers ( p < @ ) .", "sentence_id": 4}
+{"abstract_id": "24622120", "label": "results", "text": "Adding serial measurement to the base model appeared to improve the model 's predictive ability ( with sST@ showing the most promise ) , but it is not clear whether this addition is a unique contribution .", "sentence_id": 5}
+{"abstract_id": "24622120", "label": "results", "text": "However , when time-dependent factors were included , only sST@ serial measurement independently added to the risk model ( odds ratio : @ ; @ % confidence interval : @ to @ ; p = @ ) and predicted reverse myocardial remodeling ( odds ratio : @ ; @ % confidence interval : @ to @ ; p = @ ) .", "sentence_id": 6}
+{"abstract_id": "24622120", "label": "conclusions", "text": "In patients with chronic HF , baseline measurement of novel biomarkers added independent prognostic information to clinical variables and NT-proBNP .", "sentence_id": 7}
+{"abstract_id": "24622120", "label": "conclusions", "text": "Only serial measurement of sST@ appeared to add prognostic information to baseline concentrations and predicted change in left ventricular function .", "sentence_id": 8}
+{"abstract_id": "24622120", "label": "conclusions", "text": "( Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting ( PROTECT ) -RSB- ; NCT@ ) .", "sentence_id": 9}
+{"abstract_id": "24291054", "label": "background", "text": "Diabetes mellitus is associated with oxidative stress which impairs the platelet function .", "sentence_id": 0}
+{"abstract_id": "24291054", "label": "background", "text": "Phyllanthus emblica extract a rich source of vitamin C plays an important role in scavenging free radicals .", "sentence_id": 1}
+{"abstract_id": "24291054", "label": "background", "text": "The effect of vitamin C on platelet aggregation in healthy and coronary artery disease patients has been demonstrated .", "sentence_id": 2}
+{"abstract_id": "24291054", "label": "background", "text": "The present study attempts to study the pharmacodynamic interactions of P. emblica extract with clopidogrel and ecosprin .", "sentence_id": 3}
+{"abstract_id": "24291054", "label": "methods", "text": "This was a randomized open label crossover study of @ type II diabetic patients .", "sentence_id": 4}
+{"abstract_id": "24291054", "label": "methods", "text": "The dosage schedules were either single dose of @ mg P. emblica extract or @ mg clopidogrel or @ mg ecosprin or @ mg P. emblica +@ mg clopidogrel or @ mg P. emblica +@ mg ecosprin .", "sentence_id": 5}
+{"abstract_id": "24291054", "label": "methods", "text": "After single dose study and washout period , patients received either @ mg P. emblica extract twice daily or @ mg clopidogrel or @ mg ecosprin once daily or combinations for @ days .", "sentence_id": 6}
+{"abstract_id": "24291054", "label": "methods", "text": "Platelet aggregation was measured at baseline and at @h of treatment after single and multiple dose study along with recording of bleeding and clotting time .", "sentence_id": 7}
+{"abstract_id": "24291054", "label": "results", "text": "After single and multiple dose administration of the three treatments and with combinations there was statistically significant decrease of platelet aggregation compared to baseline .", "sentence_id": 8}
+{"abstract_id": "24291054", "label": "results", "text": "Further , the mean percent inhibition of platelet aggregation was significant , when compared between single and multiple doses of P. emblica .", "sentence_id": 9}
+{"abstract_id": "24291054", "label": "results", "text": "The bleeding and clotting time was prolonged with single and multiple dose administration of all treatments compared to baseline .", "sentence_id": 10}
+{"abstract_id": "24291054", "label": "results", "text": "All treatments were well tolerated .", "sentence_id": 11}
+{"abstract_id": "24291054", "label": "conclusions", "text": "P. emblica extract demonstrated significant antiplatelet activity with both single and multiple dose administration .", "sentence_id": 12}
+{"abstract_id": "24825805", "label": "objective", "text": "To compare the efficacy and safety of intramuscular meperidine injection with periprostatic nerve block ( PNB ) during transrectal ultrasound-guided prostate biopsy .", "sentence_id": 0}
+{"abstract_id": "24825805", "label": "methods", "text": "This study was carried out from July @ to June @ at the First Affiliated Hospital of Fujian Medical University , Fuzhou , Fujian , China .", "sentence_id": 1}
+{"abstract_id": "24825805", "label": "methods", "text": "This controlled , double-blinded , randomized study included @ patients .", "sentence_id": 2}
+{"abstract_id": "24825805", "label": "methods", "text": "These patients were randomly assigned to @ treatment groups : PNB by injection @ minutes prior to the prostate biopsy ; intramuscular meperidine injection administered @ minutes before the biopsy , and a control group ( n = @ , each ) .", "sentence_id": 3}
+{"abstract_id": "24825805", "label": "methods", "text": "At the time of ultrasound probe insertion , during biopsy , and @ minutes after biopsy , patients graded their level of pain on a @-point visual analog scale ( VAS ) .", "sentence_id": 4}
+{"abstract_id": "24825805", "label": "results", "text": "There was no statistical difference in clinical features of the @ groups .", "sentence_id": 5}
+{"abstract_id": "24825805", "label": "results", "text": "The patients administered meperidine had the minimum mean VAS score during probe insertion .", "sentence_id": 6}
+{"abstract_id": "24825805", "label": "results", "text": "During the prostate biopsy , there was no significant difference in VAS scores between patients in the PNB and meperidine groups , and both were significantly lower than that of the control group .", "sentence_id": 7}
+{"abstract_id": "24825805", "label": "results", "text": "The VAS scores recorded @ minutes after biopsy were similar among the @ groups .", "sentence_id": 8}
+{"abstract_id": "24825805", "label": "conclusions", "text": "Intramuscular meperidine injection is a safe and effective analgesic for use during transrectal ultrasound-guided prostate biopsy , and provides better analgesia than PNB during the probe insertion .", "sentence_id": 9}
+{"abstract_id": "24807604", "label": "background", "text": "Dyschezia is a defecatory disorder that places a heavy burden on a patient 's quality of life .", "sentence_id": 0}
+{"abstract_id": "24807604", "label": "background", "text": "Biofeedback is the recommended treatment in most cases .", "sentence_id": 1}
+{"abstract_id": "24807604", "label": "objective", "text": "The objective of our study was to test whether a CO@-releasing suppository for patients with dyschezia could be effective in improving biofeedback training results .", "sentence_id": 2}
+{"abstract_id": "24807604", "label": "methods", "text": "A randomized , double-blind , multicenter , placebo-controlled study was conducted in patients ( @-@ years of age ) with dyschezia defined according to the modified Rome III criteria .", "sentence_id": 3}
+{"abstract_id": "24807604", "label": "methods", "text": "Patients were randomly assigned to either a CO@-releasing suppository or placebo suppository once per day for @ days .", "sentence_id": 4}
+{"abstract_id": "24807604", "label": "methods", "text": "This was a multicenter trial .", "sentence_id": 5}
+{"abstract_id": "24807604", "label": "methods", "text": "A total of @ patients were randomly assigned ( @ intervention group and @ placebo group ) .", "sentence_id": 6}
+{"abstract_id": "24807604", "label": "methods", "text": "The primary end point was the change from day @ to day @ in intensity of symptoms on the basis of a self-assessed dyschezia using a visual analog scale ( range , @-@ ) .", "sentence_id": 7}
+{"abstract_id": "24807604", "label": "methods", "text": "Analyses were performed using intention-to-treat principles .", "sentence_id": 8}
+{"abstract_id": "24807604", "label": "results", "text": "A greater reduction from baseline to day @ in symptom visual analog scale score was observed in the intervention group ( -@ mm ) than in the control group ( -@ mm ) .", "sentence_id": 9}
+{"abstract_id": "24807604", "label": "results", "text": "Some secondary efficacy parameters improved more in the intervention group , including the percentage of patients who improved @ % , symptom intensity over @ days , stool stains on underwear or pads , and need to practice manual maneuvers to facilitate defecation at day @ .", "sentence_id": 10}
+{"abstract_id": "24807604", "label": "results", "text": "At day @ , rectal sensitivity in the intervention group ( @ mL ) was lower than in the control group ( @ mL ) .", "sentence_id": 11}
+{"abstract_id": "24807604", "label": "conclusions", "text": "There was a lower number of patients recruited than planned by the protocol .", "sentence_id": 12}
+{"abstract_id": "24807604", "label": "conclusions", "text": "The sponsor stopped the trial before the inclusion of @ participants , with no intermediate analysis .", "sentence_id": 13}
+{"abstract_id": "24807604", "label": "conclusions", "text": "In addition , the main analysis conducted on the full analysis set population could have led to a statistical bias .", "sentence_id": 14}
+{"abstract_id": "24807604", "label": "conclusions", "text": "The results of this multicenter trial demonstrate the added benefits of a CO@-releasing suppository in patients with dyschezia who were treated by anorectal biofeedback training .", "sentence_id": 15}
+{"abstract_id": "25188403", "label": "objective", "text": "To investigate the effects of inhaler device technique education on improving inhaler technique in older people with asthma .", "sentence_id": 0}
+{"abstract_id": "25188403", "label": "methods", "text": "In a randomised controlled trial , device technique education was provided to a sample of @ adults aged > @ years who had a doctor diagnosis of asthma .", "sentence_id": 1}
+{"abstract_id": "25188403", "label": "methods", "text": "The active education group received one-on-one technique coaching , including observation , verbal instruction and physical demonstration at baseline .", "sentence_id": 2}
+{"abstract_id": "25188403", "label": "methods", "text": "The passive group received a device-specific instruction pamphlet only .", "sentence_id": 3}
+{"abstract_id": "25188403", "label": "methods", "text": "Inhaler technique , including the critical steps for each device type , was assessed and scored according to Australian National Asthma Council ( NAC ) guidelines .", "sentence_id": 4}
+{"abstract_id": "25188403", "label": "methods", "text": "Device technique was scored objectively at baseline and again at @ and @ months post education .", "sentence_id": 5}
+{"abstract_id": "25188403", "label": "results", "text": "The majority of participants demonstrated poor technique at baseline .", "sentence_id": 6}
+{"abstract_id": "25188403", "label": "results", "text": "Only @ ( @ % ) of the active intervention group and @ ( @ % ) of the passive group demonstrated @ % correct technique .", "sentence_id": 7}
+{"abstract_id": "25188403", "label": "results", "text": "By @ months @ ( @ % ) of the active group achieved adequate technique .", "sentence_id": 8}
+{"abstract_id": "25188403", "label": "results", "text": "Improvement in technique was observed in the active group at @ months ( P < @ ) and remained significant at @ months ( P < @ ) .", "sentence_id": 9}
+{"abstract_id": "25188403", "label": "results", "text": "No statistically significant improvement was observed in the passive group .", "sentence_id": 10}
+{"abstract_id": "25188403", "label": "conclusions", "text": "The provision of active device technique education improves device technique in older adults .", "sentence_id": 11}
+{"abstract_id": "25188403", "label": "conclusions", "text": "Passive education alone fails to achieve any improvement in device technique .", "sentence_id": 12}
+{"abstract_id": "24906491", "label": "background", "text": "We sought to determine whether empirical nesiritide or milrinone would improve the early postoperative course after Fontan surgery .", "sentence_id": 0}
+{"abstract_id": "24906491", "label": "background", "text": "We hypothesized that compared with milrinone or placebo , patients assigned to receive nesiritide would have improved early postoperative outcomes .", "sentence_id": 1}
+{"abstract_id": "24906491", "label": "results", "text": "In a single-center , randomized , double-blinded , placebo-controlled , multi-arm parallel-group clinical trial , patients undergoing primary Fontan surgery were assigned to receive nesiritide , milrinone , or placebo .", "sentence_id": 2}
+{"abstract_id": "24906491", "label": "results", "text": "A loading dose of study drug was administered on cardiopulmonary bypass followed by a continuous infusion for @ hours and @ days after cardiac intensive care unit admission .", "sentence_id": 3}
+{"abstract_id": "24906491", "label": "results", "text": "The primary outcome was days alive and out of the hospital within @ days of surgery .", "sentence_id": 4}
+{"abstract_id": "24906491", "label": "results", "text": "Secondary outcomes included measures of cardiovascular function , renal function , resource use , and adverse events .", "sentence_id": 5}
+{"abstract_id": "24906491", "label": "results", "text": "Among @ enrolled subjects , @ , @ , and @ were randomized to the nesiritide , milrinone , and placebo groups , respectively , and all were analyzed based on intention to treat .", "sentence_id": 6}
+{"abstract_id": "24906491", "label": "results", "text": "Demographics , patient characteristics , and operative factors were similar among treatment groups .", "sentence_id": 7}
+{"abstract_id": "24906491", "label": "results", "text": "No significant treatment group differences were found for median days alive and out of the hospital within @ days of surgery ( nesiritide , @ -LSB- minimum to maximum , @-@ -RSB- ; milrinone , @ -LSB- @-@ -RSB- ; placebo , @ -LSB- @-@ -RSB- ; P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24906491", "label": "results", "text": "Treatment groups did not significantly differ in cardiac index , arrhythmias , peak lactate , inotropic scores , urine output , duration of mechanical ventilation , intensive care or chest tube drainage , or adverse events .", "sentence_id": 9}
+{"abstract_id": "24906491", "label": "conclusions", "text": "Compared with placebo , empirical perioperative nesiritide or milrinone infusions are not associated with improved early clinical outcomes after Fontan surgery .", "sentence_id": 10}
+{"abstract_id": "25622666", "label": "objective", "text": "To explore the application of optimal monochromatic images according to computed tomography ( CT ) values of conventional CT scans with high concentration contrast agent and the feasibility in guiding abdominal arteries imaging with low concentration contrast .", "sentence_id": 0}
+{"abstract_id": "25622666", "label": "methods", "text": "From March @ to February @ , @ patients of suspected celiac disease with a body mass index ( BMI ) of > @ kg/m ( @ ) underwent spectral CT scan .", "sentence_id": 1}
+{"abstract_id": "25622666", "label": "methods", "text": "And they were randomly divided into two groups .", "sentence_id": 2}
+{"abstract_id": "25622666", "label": "methods", "text": "In group A ( n = @ ) , @ mgI/ml low concentrations of contrast agents and spectral CT imaging ; in group B ( n = @ ) , @ mgI/ml high concentrations of contrast agents and @ kVp scan .", "sentence_id": 3}
+{"abstract_id": "25622666", "label": "methods", "text": "For CT values of the first measurement of abdominal aorta B group of patients , the average CT value was calculated .", "sentence_id": 4}
+{"abstract_id": "25622666", "label": "methods", "text": "The optimal monochromatic images of group A according to CT values of group B were reconstructed and @ keV images ( group C ) also reconstructed .", "sentence_id": 5}
+{"abstract_id": "25622666", "label": "methods", "text": "The CT values of hepatic , splenic , right renal and superior mesenteric arteries were measured and contrast to noise ratios ( CNRs ) calculated .", "sentence_id": 6}
+{"abstract_id": "25622666", "label": "methods", "text": "CT values and CNR were compared through t test on independent samples .", "sentence_id": 7}
+{"abstract_id": "25622666", "label": "methods", "text": "P > @ indicated no significant difference .", "sentence_id": 8}
+{"abstract_id": "25622666", "label": "results", "text": "Mean CT value of abdominal aorta was ( @ @ ) HU in group B. And optimal keV was ( @ @ ) keV in group A. CT values of abdominal aorta and its branches showed no statistical significance ; the CNRs of abdominal aorta and its branches showed statistical significance .", "sentence_id": 9}
+{"abstract_id": "25622666", "label": "results", "text": "The scoring consistency between two observers was excellent and the score ( @ @ vs @ @ ) showed no significant difference ( P > @ ) .", "sentence_id": 10}
+{"abstract_id": "25622666", "label": "conclusions", "text": "GSI abdominal scans with low concentration contrast may obtain better image qualities compared to conventional CTA of high concentration .", "sentence_id": 11}
+{"abstract_id": "25622666", "label": "conclusions", "text": "And ( @ @ ) keV is recommended .", "sentence_id": 12}
+{"abstract_id": "24256671", "label": "background", "text": "Platelet transfusion is increasingly used in patients with traumatic intracranial hemorrhage ( ICH ) on aspirin therapy to minimize the progression of ICH .", "sentence_id": 0}
+{"abstract_id": "24256671", "label": "background", "text": "We hypothesized ( null ) that platelet transfusion in this cohort of patients does not improve platelet function .", "sentence_id": 1}
+{"abstract_id": "24256671", "label": "methods", "text": "We performed a prospective interventional trail on patients with traumatic ICH on daily high-dose ( @ mg ) aspirin therapy .", "sentence_id": 2}
+{"abstract_id": "24256671", "label": "methods", "text": "All patients received one pack of apheresis platelets .", "sentence_id": 3}
+{"abstract_id": "24256671", "label": "methods", "text": "Blood samples were collected before and @ hour after platelet transfusion .", "sentence_id": 4}
+{"abstract_id": "24256671", "label": "methods", "text": "Platelet function was assessed using Verify Now Platelet Function Assay , and a cutoff of greater than @ aspirin reaction units was used to define functioning platelets ( FP ) .", "sentence_id": 5}
+{"abstract_id": "24256671", "label": "results", "text": "Twenty-eight patients were enrolled in the study .", "sentence_id": 6}
+{"abstract_id": "24256671", "label": "results", "text": "On presentation , @ % ( @ of @ ) of the patients had nonfunctioning platelets ( NFPs ) , and transfusion of platelets did not improve platelet function as @ % ( @ of @ ) still had NFP .", "sentence_id": 7}
+{"abstract_id": "24256671", "label": "results", "text": "Of the @ patients , @ converted from NFP to FP after transfusion .", "sentence_id": 8}
+{"abstract_id": "24256671", "label": "results", "text": "There was no difference in the progression of ICH ( @ % vs. @ % , p = @ ) or neurosurgical intervention ( @ % vs. @ % , p = @ ) between patients with FP and NFP after platelet transfusion .", "sentence_id": 9}
+{"abstract_id": "24256671", "label": "conclusions", "text": "Administration of one pack of apheresis platelet did not improve platelet function .", "sentence_id": 10}
+{"abstract_id": "24256671", "label": "conclusions", "text": "In our study , progression of ICH and the need for neurosurgical intervention were independent of platelet function .", "sentence_id": 11}
+{"abstract_id": "24256671", "label": "conclusions", "text": "Further randomized clinical trials are required to assess both the dose dependence effect and role of platelet transfusion in patients on antiplatelet therapy with traumatic ICH .", "sentence_id": 12}
+{"abstract_id": "24256671", "label": "methods", "text": "Therapeutic study , level III .", "sentence_id": 13}
+{"abstract_id": "25920649", "label": "objective", "text": "To compare the short-term functional outcome after computer-assisted total knee arthroplasty ( TKA ) versus conventional TKA .", "sentence_id": 0}
+{"abstract_id": "25920649", "label": "methods", "text": "@ men and @ women aged @ to @ years were randomised to undergo ( @ ) conventional TKA using an intramedullary guide , ( @ ) conventional TKA using an extramedullary guide , or ( @ ) computer-assisted TKA .", "sentence_id": 1}
+{"abstract_id": "25920649", "label": "methods", "text": "Two senior surgeons performed all the TKAs using the same TKA system and the standard anteromedial arthrotomy with eversion of the patella .", "sentence_id": 2}
+{"abstract_id": "25920649", "label": "methods", "text": "Patients were assessed by physiotherapists before and @ months and @ years after TKA using the Short Form-@ Health Survey , Oxford Knee Score , and Knee Society Score .", "sentence_id": 3}
+{"abstract_id": "25920649", "label": "results", "text": "Of the @ patients , @ and @ were assessed at @ months and @ years after TKA , respectively .", "sentence_id": 4}
+{"abstract_id": "25920649", "label": "results", "text": "No patient developed deep infection or required revision surgery .", "sentence_id": 5}
+{"abstract_id": "25920649", "label": "results", "text": "Functional outcomes of the @ groups did not differ significantly at the corresponding follow-ups .", "sentence_id": 6}
+{"abstract_id": "25920649", "label": "conclusions", "text": "Significant improvement in the functional outcome was not shown in patients treated with computer-assisted TKA , compared with conventional TKA .", "sentence_id": 7}
+{"abstract_id": "25920649", "label": "conclusions", "text": "Thus , computer-assisted TKA has limited additional short-term benefits .", "sentence_id": 8}
+{"abstract_id": "25920649", "label": "conclusions", "text": "Further studies with longer follow-up are required to examine the benefits of computer-assisted TKA .", "sentence_id": 9}
+{"abstract_id": "25336745", "label": "objective", "text": "We aim to characterize the effects on total body fat and distribution of a @-year intensive lifestyle intervention ( ILI ) for weight loss in overweight and obese adults with type @ diabetes and to examine whether changes in adipose tissue ( AT ) depots were associated with changes in metabolic biomarkers .", "sentence_id": 0}
+{"abstract_id": "25336745", "label": "methods", "text": "Participants were @ females and @ males ( age @ @ years -LSB- mean SD -RSB- ; BMI @ @ kg/m ( @ ) ) enrolled in the Look AHEAD ( Action for Health in Diabetes ) trial randomized to ILI or diabetes support and education ( DSE ) from whom baseline and @-year MRI measures of total AT ( TAT ) and regional ( arm , trunk , leg ) AT , including subcutaneous AT ( SAT ) , visceral AT ( VAT ) , and intermuscular AT ( IMAT ) , were acquired .", "sentence_id": 1}
+{"abstract_id": "25336745", "label": "methods", "text": "We tested whether mean changes in ILI and DSE were equal and , within groups , whether changes were different from zero .", "sentence_id": 2}
+{"abstract_id": "25336745", "label": "methods", "text": "Regression models tested whether changes in AT compartments were associated with metabolic variable changes .", "sentence_id": 3}
+{"abstract_id": "25336745", "label": "results", "text": "Body weight changed -@ @ kg ( P = @ ) in DSE and -@ @ kg ( P < @ ) in ILI .", "sentence_id": 4}
+{"abstract_id": "25336745", "label": "results", "text": "Mean ILI changes were different from DSE ( P < @ for TAT , SAT , and IMAT and P < @ for VAT in females ) .", "sentence_id": 5}
+{"abstract_id": "25336745", "label": "results", "text": "Within ILI , SAT and VAT decreased in males and females ( P < @ ) , but IMAT was unchanged ( @ @ kg ; P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25336745", "label": "results", "text": "In DSE , SAT and VAT did not change , but IMAT increased by @ @ kg ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25336745", "label": "results", "text": "Controlling for weight loss , reduction of specific AT depots was associated with improvement in metabolic biomarkers .", "sentence_id": 8}
+{"abstract_id": "25336745", "label": "conclusions", "text": "Weight loss of @-@ % from an ILI over @ year reduced SAT and VAT and prevented an increase in IMAT .", "sentence_id": 9}
+{"abstract_id": "25336745", "label": "conclusions", "text": "Reductions in AT depots were associated with improvements in biomarkers .", "sentence_id": 10}
+{"abstract_id": "24442048", "label": "objective", "text": "Psoriasis is a systemic inflammatory immune-mediated skin disease .", "sentence_id": 0}
+{"abstract_id": "24442048", "label": "objective", "text": "Recently a relationship with metabolic syndrome in terms of psoriasis severity and response to therapy was observed .", "sentence_id": 1}
+{"abstract_id": "24442048", "label": "methods", "text": "We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q@ coenzyme , Krill-oil , lipoic acid , resveratrol , Vitis vinifera seed oil , vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome .", "sentence_id": 2}
+{"abstract_id": "24442048", "label": "methods", "text": "Forty patients were enrolled and divided into two arms , one receiving only etanercept , one other receiving also the neutraceutical .", "sentence_id": 3}
+{"abstract_id": "24442048", "label": "methods", "text": "After a period of @ months ( T@ ) a second evaluation of the considered parameters was performed .", "sentence_id": 4}
+{"abstract_id": "24442048", "label": "results", "text": "At T@ statistically significant differences were detected in HDL cholesterol and triglycerides values both comparing the two arms and in the nutraceutical arm .", "sentence_id": 5}
+{"abstract_id": "24442048", "label": "conclusions", "text": "Our results show that the dietary addiction of the nutraceutical to the etanercept therapy in patients affected by both psoriasis and metabolic syndrome could help to restore the normal lipid profile .", "sentence_id": 6}
+{"abstract_id": "24334216", "label": "background", "text": "Sexual health problems such as unwanted pregnancy and sexually transmitted infection are important public health concerns and there is huge potential for health promotion using digital interventions .", "sentence_id": 0}
+{"abstract_id": "24334216", "label": "background", "text": "Evaluations of digital interventions are increasingly conducted online .", "sentence_id": 1}
+{"abstract_id": "24334216", "label": "background", "text": "Trial administration and data collection online offers many advantages , but concerns remain over fraudulent registration to obtain compensation , the quality of self-reported data , and high attrition .", "sentence_id": 2}
+{"abstract_id": "24334216", "label": "objective", "text": "This study addresses the feasibility of several dimensions of online trial design-recruitment , online consent , participant identity verification , randomization and concealment of allocation , online data collection , data quality , and retention at @-month follow-up .", "sentence_id": 3}
+{"abstract_id": "24334216", "label": "methods", "text": "Young people aged @ to @ years and resident in the United Kingdom were recruited to the `` Sexunzipped '' online trial between November @ and March @ ( n = @ ) .", "sentence_id": 4}
+{"abstract_id": "24334216", "label": "methods", "text": "Participants filled in baseline demographic and sexual health questionnaires online and were randomized to the Sexunzipped interactive intervention website or to an information-only control website .", "sentence_id": 5}
+{"abstract_id": "24334216", "label": "methods", "text": "Participants were also randomly allocated to a postal request ( or no request ) for a urine sample for genital chlamydia testing and receipt of a lower ( @/US $ @ ) or higher ( @/US $ @ ) value shopping voucher compensation for @-month outcome data .", "sentence_id": 6}
+{"abstract_id": "24334216", "label": "results", "text": "The majority of the @ valid participants ( @ % , @/@ ) were aged between @ and @ years at enrolment , from all four countries in the United Kingdom .", "sentence_id": 7}
+{"abstract_id": "24334216", "label": "results", "text": "Most were white ( @ % , @/@ ) , most were in school or training ( @ % , @/@ ) , and @ % ( @/@ ) of the sample were female .", "sentence_id": 8}
+{"abstract_id": "24334216", "label": "results", "text": "In total , @ % ( @/@ ) of registrations appeared to be invalid and another @ % ( @/@ ) of participants gave inconsistent responses within the questionnaire .", "sentence_id": 9}
+{"abstract_id": "24334216", "label": "results", "text": "The higher value compensation ( @/US $ @ ) increased response rates by @-@ % , boosting retention at @ months to @ % ( @/@ ) for submission of online self-reported sexual health outcomes and @ % ( @/@ ) for return of chlamydia urine samples by post .", "sentence_id": 10}
+{"abstract_id": "24334216", "label": "conclusions", "text": "It was quick and efficient to recruit young people to this online trial .", "sentence_id": 11}
+{"abstract_id": "24334216", "label": "conclusions", "text": "Our procedures for obtaining online consent , verifying participant identity , automated randomization , and concealment of allocation worked well .", "sentence_id": 12}
+{"abstract_id": "24334216", "label": "conclusions", "text": "The optimal response rate for the online sexual health outcome measurement was comparable to face-to-face trials .", "sentence_id": 13}
+{"abstract_id": "24334216", "label": "conclusions", "text": "Multiple methods of participant contact , requesting online data only , and higher value compensation increased trial retention at @-month follow-up .", "sentence_id": 14}
+{"abstract_id": "24534413", "label": "objective", "text": "We conducted a randomized trial to test the hypothesis that mother 's voice played through a pacifier-activated music player ( PAM ) during nonnutritive sucking would improve the development of sucking ability and promote more effective oral feeding in preterm infants .", "sentence_id": 0}
+{"abstract_id": "24534413", "label": "methods", "text": "Preterm infants between @@/@ and @@/@ weeks ' postmenstrual age , including those with brain injury , who were taking at least half their feedings enterally and less than half orally , were randomly assigned to receive @ daily @-minute sessions of either PAM with mother 's recorded voice or no PAM , along with routine nonnutritive sucking and maternal care in both groups .", "sentence_id": 1}
+{"abstract_id": "24534413", "label": "methods", "text": "Assignment was masked to the clinical team .", "sentence_id": 2}
+{"abstract_id": "24534413", "label": "results", "text": "Ninety-four infants ( @ and @ in the PAM intervention and control groups , respectively ) completed the study .", "sentence_id": 3}
+{"abstract_id": "24534413", "label": "results", "text": "The intervention group had significantly increased oral feeding rate ( @ vs. @ mL/min , P < @ ) , oral volume intake ( @ vs. @ mL/kg/d , P = @ ) , oral feeds/day ( @ vs. @ , P < @ ) , and faster time-to-full oral feedings ( @ vs. @ d , P = @ ) compared with controls .", "sentence_id": 4}
+{"abstract_id": "24534413", "label": "results", "text": "Weight gain and cortisol levels during the @-day protocol were not different between groups .", "sentence_id": 5}
+{"abstract_id": "24534413", "label": "results", "text": "Average hospital stays were @ % shorter in the PAM group , but the difference was not significant ( P = @ ) .", "sentence_id": 6}
+{"abstract_id": "24534413", "label": "conclusions", "text": "A PAM using mother 's voice improves oral feeding skills in preterm infants without adverse effects on hormonal stress or growth .", "sentence_id": 7}
+{"abstract_id": "26258311", "label": "objective", "text": "To determine the safety and efficacy of cryopreserved packed red blood cell ( CPRBC ) transfusion in trauma patients .", "sentence_id": 0}
+{"abstract_id": "26258311", "label": "background", "text": "Liquid packed red blood cells ( LPRBCs ) have an abbreviated shelf-life and worsening storage lesion with age .", "sentence_id": 1}
+{"abstract_id": "26258311", "label": "background", "text": "CPRBCs are frozen @ to @ days after donation , stored up to @ years , and are available for @ days after thawing and washing .", "sentence_id": 2}
+{"abstract_id": "26258311", "label": "background", "text": "CPRBCs can be utilized in diverse settings , but the effect on clinical outcomes is unknown .", "sentence_id": 3}
+{"abstract_id": "26258311", "label": "methods", "text": "We performed a prospective , randomized , double-blind study at @ level @ trauma centers .", "sentence_id": 4}
+{"abstract_id": "26258311", "label": "methods", "text": "Stable trauma patients requiring transfusion were randomized to young LPRBCs ( @ storage days ) , old LPRBCs ( > @ storage days ) , or CPRBCs .", "sentence_id": 5}
+{"abstract_id": "26258311", "label": "methods", "text": "Tissue oxygenation ( StO@ ) , biochemical and inflammatory mediators were measured , and clinical outcomes were determined .", "sentence_id": 6}
+{"abstract_id": "26258311", "label": "results", "text": "Two hundred fifty-six patients with well-matched injury severity and demographics ( P > @ ) were randomized ( @ young , @ old , and @ CPRBCs ) .", "sentence_id": 7}
+{"abstract_id": "26258311", "label": "results", "text": "Pretransfusion and final hematocrits were similar ( P > @ ) .", "sentence_id": 8}
+{"abstract_id": "26258311", "label": "results", "text": "Patients in all groups received the same number of units postrandomization ( @ -LSB- @-@ -RSB- ; P > @ ) .", "sentence_id": 9}
+{"abstract_id": "26258311", "label": "results", "text": "There was no difference in the change in tissue oxygenation between groups .", "sentence_id": 10}
+{"abstract_id": "26258311", "label": "results", "text": "CPRBCs contained less @-macrogobulin , haptoglobin , C-reactive protein , and serum amyloid P ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "26258311", "label": "results", "text": "Organ failure , infection rate , and mortality did not differ between groups ( P > @ ) .", "sentence_id": 12}
+{"abstract_id": "26258311", "label": "conclusions", "text": "Transfusion of CPRBCs is as safe and effective as transfusion of young and old LPRBCs and provides a mechanism to deliver PRBCs in a wide variety of settings .", "sentence_id": 13}
+{"abstract_id": "25394474", "label": "background", "text": "Halitosis is a common problem that affects a large portion of the population worldwide .", "sentence_id": 0}
+{"abstract_id": "25394474", "label": "background", "text": "The origin of this condition is oral in @ % and systemic in @ % of cases .", "sentence_id": 1}
+{"abstract_id": "25394474", "label": "background", "text": "The unpleasant odor is mainly the result of volatile sulfur compounds produced by Gram-negative bacteria .", "sentence_id": 2}
+{"abstract_id": "25394474", "label": "background", "text": "However , it has recently been found that anaerobic Gram-positive bacteria also produce hydrogen sulfide ( H@S ) in the presence of amino acids , such as cysteine .", "sentence_id": 3}
+{"abstract_id": "25394474", "label": "background", "text": "Light , both with and without the use of chemical agents , has been used to induce therapeutic and antimicrobial effects .", "sentence_id": 4}
+{"abstract_id": "25394474", "label": "background", "text": "In photodynamic therapy , the antimicrobial effect is confined to areas covered by photosensitizing dye .", "sentence_id": 5}
+{"abstract_id": "25394474", "label": "background", "text": "The aim of the present study is to evaluate the antimicrobial effect of photodynamic therapy on halitosis in adolescents through the analysis of volatile sulfur compounds measured using gas chromatography and microbiological analysis of coated tongue .", "sentence_id": 6}
+{"abstract_id": "25394474", "label": "methods", "text": "A quantitative clinical trial will be carried out involving @ adolescents randomly divided into the following groups : group @ will receive treatment with a tongue scraper , group @ will receive photodynamic therapy applied to the posterior two-thirds of the dorsum of the tongue , and group @ will receive combined treatment ( tongue scraper and photodynamic therapy ) .", "sentence_id": 7}
+{"abstract_id": "25394474", "label": "methods", "text": "Gas chromatography ( OralChromaTM ) and microbiological analysis will be used for the diagnosis of halitosis at the beginning of the study .", "sentence_id": 8}
+{"abstract_id": "25394474", "label": "methods", "text": "Post-treatment evaluations will be conducted at one hour and @hours after treatment .", "sentence_id": 9}
+{"abstract_id": "25394474", "label": "methods", "text": "The statistical analysis will include the Shapiro-Wilk test for the determination of the distribution of the data .", "sentence_id": 10}
+{"abstract_id": "25394474", "label": "methods", "text": "If normal distribution is demonstrated , analysis of variance followed by Tukey 's test will be used to compare groups .", "sentence_id": 11}
+{"abstract_id": "25394474", "label": "methods", "text": "The Kruskal-Wallis test followed by the Student-Newman-Keuls test will be used for data with non-normal distribution .", "sentence_id": 12}
+{"abstract_id": "25394474", "label": "methods", "text": "Either the paired t-test or the Wilcoxon test will be used to compare data before and after treatment , depending on the distribution of the data .", "sentence_id": 13}
+{"abstract_id": "25394474", "label": "conclusions", "text": "The results of this trial will determine the efficacy of using photodynamic therapy alone or in combination with a tongue scraper to treat bad breath in adolescents .", "sentence_id": 14}
+{"abstract_id": "25400471", "label": "objective", "text": "To compare efficacy , patient compliance , acceptability , satisfaction , safety , and adenoma detection rate of sodium phosphate tablets ( NaP , CLICOLON ( TM ) ) to a standard @ L polyethylene glycol ( PEG ) solution for bowel cleansing for adults undergoing colonoscopy .", "sentence_id": 0}
+{"abstract_id": "25400471", "label": "methods", "text": "In this multicenter , randomized , prospective , investigator-blind study , the relatively young ( @-@ years ) healthy outpatients without comorbidity were randomly assigned to one of two arms .", "sentence_id": 1}
+{"abstract_id": "25400471", "label": "methods", "text": "All colonoscopy were scheduled in the morning .", "sentence_id": 2}
+{"abstract_id": "25400471", "label": "methods", "text": "The NaP group was asked to take @ tablets , @ times the evening before and @ tablets , @ times early on the morning of the colonoscopy .", "sentence_id": 3}
+{"abstract_id": "25400471", "label": "methods", "text": "The PEG group was asked to ingest @ L of solution the evening before and @ L early in the morning of the procedure .", "sentence_id": 4}
+{"abstract_id": "25400471", "label": "methods", "text": "Adequacy of bowel preparation was scored using the Boston bowel preparation scale .", "sentence_id": 5}
+{"abstract_id": "25400471", "label": "results", "text": "No significant differences were observed between the NaP group ( n = @ ) and PEG group ( n = @ ) in bowel cleansing quality ( adequate preparation @ % vs @ % , P = @ ) , patient compliance ( P = @ ) , overall adverse events ( @ % vs @ % , P = @ ) , or adenoma detection rate ( @ % vs @ % , P = @ ) .", "sentence_id": 6}
+{"abstract_id": "25400471", "label": "results", "text": "Patient acceptability , satisfaction , and patient rating of taste were higher in the NaP group than in the PEG group ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "25400471", "label": "conclusions", "text": "NaP tablets , compared with PEG solution , produced equivalent colon cleansing , did not cause more side effects , and had better patient acceptability and satisfaction in the relatively young ( age < @ years ) healthy individuals without comorbidity .", "sentence_id": 8}
+{"abstract_id": "25400471", "label": "conclusions", "text": "An oral tablet formulation could make bowel preparation less burdensome , resulting in greater patient participation in screening programs .", "sentence_id": 9}
+{"abstract_id": "24524414", "label": "objective", "text": "This study compared the performance of two new bone-anchored hearing aids with older bone-anchored hearing aids that were not fully digital .", "sentence_id": 0}
+{"abstract_id": "24524414", "label": "methods", "text": "Fourteen experienced bone-anchored hearing aid users participated in this cross-over study .", "sentence_id": 1}
+{"abstract_id": "24524414", "label": "methods", "text": "Performance of their existing bone-anchored hearing aid was assessed using speech-in-noise testing and questionnaires .", "sentence_id": 2}
+{"abstract_id": "24524414", "label": "methods", "text": "Participants were then fitted with either a Ponto Pro or a BP@ device .", "sentence_id": 3}
+{"abstract_id": "24524414", "label": "methods", "text": "After four weeks of use with each new device , the same assessments were repeated .", "sentence_id": 4}
+{"abstract_id": "24524414", "label": "results", "text": "Speech-in-noise testing for the @ per cent signal-to-noise ratio ( the ratio at which @ per cent of responses were correct ) showed no significant differences between the Ponto Pro and the BP@ devices ( p = @ ) However , both devices showed significant improvement compared with the participants ' previous bone-anchored hearing aid devices ( p < @ ) .", "sentence_id": 5}
+{"abstract_id": "24524414", "label": "results", "text": "There were no significant differences between the two new devices in the questionnaire data .", "sentence_id": 6}
+{"abstract_id": "24524414", "label": "conclusions", "text": "Both fully digital bone-anchored hearing aids demonstrated superior speech processing compared with the previous generation of devices .", "sentence_id": 7}
+{"abstract_id": "24524414", "label": "conclusions", "text": "There were no substantial differences between the two digital devices in either objective or subjective tests .", "sentence_id": 8}
+{"abstract_id": "24980134", "label": "background", "text": "Managing cardiovascular risk factors is important for reducing vascular complications in type @ diabetes , even in individuals who have achieved glycemic control .", "sentence_id": 0}
+{"abstract_id": "24980134", "label": "background", "text": "Nut consumption is associated with reduced cardiovascular risk ; however , there is mixed evidence about the effect of nuts on blood pressure ( BP ) , and limited research on the underlying hemodynamics .", "sentence_id": 1}
+{"abstract_id": "24980134", "label": "background", "text": "This study assessed the effect of pistachio consumption on BP , systemic hemodynamics , and heart rate variability in adults with well-controlled type @ diabetes .", "sentence_id": 2}
+{"abstract_id": "24980134", "label": "results", "text": "We enrolled @ adults ( @ to @ years ) with type @ diabetes in a randomized , crossover , controlled feeding study .", "sentence_id": 3}
+{"abstract_id": "24980134", "label": "results", "text": "After a @-week run-in period , participants consumed a low-fat control diet ( @ % fat ) containing low-fat/high-carbohydrate snacks and a moderate-fat diet ( @ % fat ) containing pistachios ( @ % of total energy ) for @ weeks each , separated by a @-week washout .", "sentence_id": 4}
+{"abstract_id": "24980134", "label": "results", "text": "Following each diet period , we assessed BP , systemic hemodynamics , and heart rate variability at rest and during acute mental stress , and , in a subset of participants ( n = @ ) , @-hour ambulatory BP .", "sentence_id": 5}
+{"abstract_id": "24980134", "label": "results", "text": "BP at rest and during stress did not differ between treatments .", "sentence_id": 6}
+{"abstract_id": "24980134", "label": "results", "text": "The pistachio diet significantly reduced total peripheral resistance ( -@ % , P = @ ) , increased cardiac output ( @ % , P = @ ) , and improved some measures of heart rate variability ( all P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24980134", "label": "results", "text": "Systolic ambulatory BP was significantly reduced by @ mm Hg ( P = @ ) following the pistachio diet , with the greatest reduction observed during sleep ( -@ mm Hg , P = @ ) .", "sentence_id": 8}
+{"abstract_id": "24980134", "label": "conclusions", "text": "A moderate-fat diet containing pistachios modestly improves some cardiovascular risk factors in adults with well-controlled type @ diabetes .", "sentence_id": 9}
+{"abstract_id": "24488742", "label": "objective", "text": "To determine how symmetric ( proportionate ; SGR ) and asymmetric ( disproportionate ; AGR ) growth restriction influence growth and development in preterms from birth to @ years .", "sentence_id": 0}
+{"abstract_id": "24488742", "label": "methods", "text": "This community-based cohort study of @ children comprised @ SGR , @ AGR , and @ non-growth restricted ( NGR ) preterms , born in @ and @ .", "sentence_id": 1}
+{"abstract_id": "24488742", "label": "methods", "text": "Symmetrical growth restriction was defined as a birth weight below the @th percentile ( -@ SD ) compared with full-terms and a head circumference ( HC ) z score not exceeding the infant 's birth weight z score by > @ SD .", "sentence_id": 2}
+{"abstract_id": "24488742", "label": "methods", "text": "Asymmetric growth restriction was defined as a HC z score exceeding that for by > @ SD as a proxy of brain sparing .", "sentence_id": 3}
+{"abstract_id": "24488742", "label": "methods", "text": "Developmental delay was assessed by the Ages and Stages Questionnaire at @ years .", "sentence_id": 4}
+{"abstract_id": "24488742", "label": "results", "text": "Longitudinal gains in weight and height were similar for SGR and AGR children and less compared with NGR children .", "sentence_id": 5}
+{"abstract_id": "24488742", "label": "results", "text": "At age @ , z scores for weight were -@ for SGR and -@ for AGR children vs -@ for NGR children .", "sentence_id": 6}
+{"abstract_id": "24488742", "label": "results", "text": "z scores for height were -@ and -@ vs. -@ .", "sentence_id": 7}
+{"abstract_id": "24488742", "label": "results", "text": "HC gain were @ cm more in SGR , but at @ year , they were -@ vs. @ ( AGR ) and @ ( NGR ) .", "sentence_id": 8}
+{"abstract_id": "24488742", "label": "results", "text": "Developmental delay increased with odds ratios of @ ( @ % confidence interval @-@ @ ) for SGR and @ ( @ % confidence interval @-@ @ ) for AGR .", "sentence_id": 9}
+{"abstract_id": "24488742", "label": "conclusions", "text": "Weight and height gains were similar for AGR and SGR children but poorer compared with NGR children .", "sentence_id": 10}
+{"abstract_id": "24488742", "label": "conclusions", "text": "SGR children caught up on HC .", "sentence_id": 11}
+{"abstract_id": "24488742", "label": "conclusions", "text": "Developmental delay was more likely in growth-restricted preterms independent of HC at birth .", "sentence_id": 12}
+{"abstract_id": "24655411", "label": "background", "text": "Recent studies have assessed the therapeutic potential and drawbacks of mesenchymal stem cells ( MSCs ) .", "sentence_id": 0}
+{"abstract_id": "24655411", "label": "background", "text": "The adverse reactions of intravenous transplantation of bone marrow ( BM ) - derived MSCs were examined at varying doses and frequencies of administration .", "sentence_id": 1}
+{"abstract_id": "24655411", "label": "background", "text": "Nine healthy beagle dogs were purchased from a commercial laboratory .", "sentence_id": 2}
+{"abstract_id": "24655411", "label": "background", "text": "The dogs were distributed equally ( n = @ per group ) and randomly into three groups .", "sentence_id": 3}
+{"abstract_id": "24655411", "label": "background", "text": "All dogs received allogeneic BM-derived MSCs : @ once ( group A ) , @ once ( group B ) , and @ for three consecutive days ( group C ) .", "sentence_id": 4}
+{"abstract_id": "24655411", "label": "background", "text": "Various laboratory examinations , multi-detector computed tomography features and histopathology were evaluated to clarify the clinical and diagnostic features of adverse reactions of MSCs administration , prior to receiving MSCs ( pre procedure ) and on days @ , @ , and @ post transplantation .", "sentence_id": 5}
+{"abstract_id": "24655411", "label": "results", "text": "Only one dog had clinical signs during and after MSCs transplantation .", "sentence_id": 6}
+{"abstract_id": "24655411", "label": "results", "text": "Dogs receiving @ MSCs showed increased numbers of lymphocytes but the total white blood cell counts were not elevated ( P < @ ) .", "sentence_id": 7}
+{"abstract_id": "24655411", "label": "results", "text": "Multi-detector computed tomography ( MDCT ) revealed pulmonary parenchymal changes in one dog and histopathologic examination revealed pulmonary parenchymal edema and hemorrhage in four dogs .", "sentence_id": 8}
+{"abstract_id": "24655411", "label": "results", "text": "The presence of pulmonary thromboembolism was not detected in either examination .", "sentence_id": 9}
+{"abstract_id": "24655411", "label": "conclusions", "text": "We considered the presence of pulmonary edema and hemorrhage as possible adverse reactions after intravenous MSCs transplantation ; however these results should be cautiously interpreted .", "sentence_id": 10}
+{"abstract_id": "24338959", "label": "background", "text": "Comparison of state-designated primary and comprehensive stroke centers ( PSCs and CSCs ) with regard to adherence to nationally accepted performance standards are scarce .", "sentence_id": 0}
+{"abstract_id": "24338959", "label": "background", "text": "The objective of this study was to examine if a significant association exists between level of designation and fulfillment of Joint Commission ( JC ) stroke core measures .", "sentence_id": 1}
+{"abstract_id": "24338959", "label": "methods", "text": "A retrospective comparative data analysis of the New Jersey acute stroke registry for the calendar years @ and @ was performed .", "sentence_id": 2}
+{"abstract_id": "24338959", "label": "methods", "text": "JC core measures were compared by hospital level ( PSCs vs CSCs ) .", "sentence_id": 3}
+{"abstract_id": "24338959", "label": "methods", "text": "Adjusted odds ratios ( aOR ) were estimated for association between hospital levels and fulfillment of JC core measures .", "sentence_id": 4}
+{"abstract_id": "24338959", "label": "methods", "text": "Median door-to-thrombolytic time was also compared .", "sentence_id": 5}
+{"abstract_id": "24338959", "label": "results", "text": "There were @,@ acute stroke admissions .", "sentence_id": 6}
+{"abstract_id": "24338959", "label": "results", "text": "PSCs had @ % of the patients , whereas CSCs had @ % .", "sentence_id": 7}
+{"abstract_id": "24338959", "label": "results", "text": "Hemorrhagic stroke admissions were about @ times more frequent at CSCs than PSCs ( @ % and @ % , respectively ) .", "sentence_id": 8}
+{"abstract_id": "24338959", "label": "results", "text": "CSCs adhered better to @ of the @ JC measures than PSCs .", "sentence_id": 9}
+{"abstract_id": "24338959", "label": "results", "text": "Of eligible patients , @ % received thrombolytic therapy at CSCs compared to @ % at PSCs , with a @ % difference in provision of thrombolytic therapy ( aOR = @ , @ % confidence interval : @-@ @ ) .", "sentence_id": 10}
+{"abstract_id": "24338959", "label": "results", "text": "Median door-to-thrombolytic drug times was @ minutes at CSCs compared to @ minutes at PSCs ( P < @ ) .", "sentence_id": 11}
+{"abstract_id": "24338959", "label": "conclusions", "text": "New Jersey state-designated CSCs are better at adhering to the JC core stroke measures and have shorter door-to-thrombolytic drug times .", "sentence_id": 12}
+{"abstract_id": "25262257", "label": "background", "text": "The prevalence and correlates of dual-antiplatelet therapy ( DAPT ) use in stable coronary artery disease ( CAD ) are unknown .", "sentence_id": 0}
+{"abstract_id": "25262257", "label": "background", "text": "In addition , whether prolonged DAPT may impact prognosis in stable CAD has not been studied in real-life conditions .", "sentence_id": 1}
+{"abstract_id": "25262257", "label": "methods", "text": "We studied @,@ patients included in a prospective registry on stable CAD .", "sentence_id": 2}
+{"abstract_id": "25262257", "label": "methods", "text": "The patients were divided in @ groups according to their antiplatelet therapy regimen at inclusion : patients treated with DAPT were compared with those treated with single-antiplatelet therapy ( SAPT ) .", "sentence_id": 3}
+{"abstract_id": "25262257", "label": "methods", "text": "The primary outcome was a composite of cardiovascular death , myocardial infarction , or stroke .", "sentence_id": 4}
+{"abstract_id": "25262257", "label": "results", "text": "Altogether , @ ( @ % ) patients received DAPT .", "sentence_id": 5}
+{"abstract_id": "25262257", "label": "results", "text": "Factors positively associated with DAPT use were persistent angina at inclusion , body mass index , myocardial infarction since @ to @ years , myocardial revascularization since @ to @ years , multivessel CAD , prior drug-eluting stent implantation , and prior aortic or peripheral intervention .", "sentence_id": 6}
+{"abstract_id": "25262257", "label": "results", "text": "Factors negatively associated with DAPT use were age , prior coronary bypass , and left ventricular ejection fraction .", "sentence_id": 7}
+{"abstract_id": "25262257", "label": "results", "text": "The rate of the primary outcome at @ years was similar whether patients were treated with SAPT ( @ % ) or DAPT ( @ % ) ( P = @ ) .", "sentence_id": 8}
+{"abstract_id": "25262257", "label": "results", "text": "Similar rates were also observed after propensity score matching : @ % when treated with SAPT versus @ % when treated with DAPT ( P = @ ) .", "sentence_id": 9}
+{"abstract_id": "25262257", "label": "results", "text": "The rate of bleeding was similar between groups .", "sentence_id": 10}
+{"abstract_id": "25262257", "label": "conclusions", "text": "Our study shows that a significant proportion of stable CAD patients are treated with DAPT in modern practice .", "sentence_id": 11}
+{"abstract_id": "25262257", "label": "conclusions", "text": "Several correlates of DAPT were identified .", "sentence_id": 12}
+{"abstract_id": "25262257", "label": "conclusions", "text": "Although no increase in bleeding was observed , our results do not support the prescription of prolonged DAPT .", "sentence_id": 13}
+{"abstract_id": "25653511", "label": "background", "text": "The objective of this study was to assess the efficacy and safety of alfuzosin @ mg monotherapy or combined antihypertensive medication on blood pressure ( BP ) in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia ( BPH/LUTS ) with or without antihypertensive medication .", "sentence_id": 0}
+{"abstract_id": "25653511", "label": "methods", "text": "This was a @-month , multicenter , randomized , open-label study in @ patients aged @ years with a clinical diagnosis of BPH/LUTS by medical history and clinical examination , a total International Prostatic Symptom Score ( IPSS ) @ points , a maximum flow rate > @ mL/sec and @ mL/sec , and a voided volume @ mL .", "sentence_id": 1}
+{"abstract_id": "25653511", "label": "methods", "text": "Eligible subjects were randomized to receive alfuzosin @ mg as monotherapy ( group @ ) or alfuzosin @ mg + antihypertensive combination therapy ( group @ ) .", "sentence_id": 2}
+{"abstract_id": "25653511", "label": "methods", "text": "Based on baseline BP and hypertensive history with or without antihypertensive medications at first medical examination , group @ was divided into two subgroups of normotensive and untreated hypertensive patients , and group @ into two subgroups of controlled hypertensive and uncontrolled hypertensive patients .", "sentence_id": 3}
+{"abstract_id": "25653511", "label": "methods", "text": "The primary study outcomes were change in IPSS , BP , and heart rate from baseline .", "sentence_id": 4}
+{"abstract_id": "25653511", "label": "methods", "text": "Secondary outcomes were change in IPSS-quality of life score , maximum flow rate , average flow rate , voided volume , and post-voided volume .", "sentence_id": 5}
+{"abstract_id": "25653511", "label": "results", "text": "The overall BP change was not significantly different between groups @ and @ ( systolic BP , P = @ ; diastolic BP , P > @ ) .", "sentence_id": 6}
+{"abstract_id": "25653511", "label": "results", "text": "In patients with uncontrolled or untreated hypertension , alfuzosin @ mg alone or combined with antihypertensive therapy significantly decreased systolic and diastolic BP .", "sentence_id": 7}
+{"abstract_id": "25653511", "label": "results", "text": "The mean difference in total IPSS and IPSS-quality of life scores from baseline between groups @ and @ was @ ( @ % CI : -@ , @ ) and @ ( @ % CI : -@ , @ ) , respectively ( both P > @ ) .", "sentence_id": 8}
+{"abstract_id": "25653511", "label": "results", "text": "Maximum flow rate , average flow rate , voided volume , and post-voided volume at endpoint were numerically , but not significantly , changed from baseline ( all P > @ ) .", "sentence_id": 9}
+{"abstract_id": "25653511", "label": "conclusions", "text": "This study shows that alfuzosin @ mg is effective and well tolerated in patients with BPH/LUTS with or without antihypertensive medications .", "sentence_id": 10}
+{"abstract_id": "25653511", "label": "conclusions", "text": "However , in patients with uncontrolled or untreated hypertension , alfuzosin @ mg alone or in combination with antihypertensive medication appears to decrease systolic and diastolic BP , and these patients should be warned about a decrease in BP on initiation of therapy .", "sentence_id": 11}
+{"abstract_id": "24720679", "label": "background", "text": "In this phase @ trial we evaluated the efficacy and safety of the interferon-free combination of ABT-@ with ritonavir ( ABT-@ / r ) , ombitasvir ( also known as ABT-@ ) , dasabuvir ( also known as ABT-@ ) , and ribavirin for the retreatment of HCV in patients who were previously treated with peginterferon-ribavirin .", "sentence_id": 0}
+{"abstract_id": "24720679", "label": "methods", "text": "We enrolled patients with HCV genotype @ infection and no cirrhosis who had previously been treated with peginterferon-ribavirin and had a relapse , a partial response , or a null response .", "sentence_id": 1}
+{"abstract_id": "24720679", "label": "methods", "text": "Patients were randomly assigned in a @:@ ratio to receive coformulated ABT-@ / r-ombitasvir ( at a once-daily dose of @ mg of ABT-@ , @ mg of ritonavir , and @ mg of ombitasvir ) and dasabuvir ( @ mg twice daily ) with ribavirin ( @ or @ mg daily ) or matching placebos during the @-week double-blind period .", "sentence_id": 2}
+{"abstract_id": "24720679", "label": "methods", "text": "The primary end point was the rate of sustained virologic response @ weeks after the end of study treatment .", "sentence_id": 3}
+{"abstract_id": "24720679", "label": "methods", "text": "The primary efficacy analysis compared this rate among patients assigned to the active regimen with a historical response rate ( @ % ) among previously treated patients with HCV genotype @ infection and no cirrhosis who had received retreatment with telaprevir and peginterferon-ribavirin .", "sentence_id": 4}
+{"abstract_id": "24720679", "label": "results", "text": "A total of @ patients received at least one study-drug dose .", "sentence_id": 5}
+{"abstract_id": "24720679", "label": "results", "text": "In the active-regimen group , @ of @ patients had a sustained virologic response at post-treatment week @ , for an overall rate of @ % ( @ % confidence interval , @ to @ ) .", "sentence_id": 6}
+{"abstract_id": "24720679", "label": "results", "text": "This rate was noninferior and superior to the historical control rate .", "sentence_id": 7}
+{"abstract_id": "24720679", "label": "results", "text": "Rates were @ % among patients with a prior relapse ( @ of @ patients ) , @ % among patients with a prior partial response ( @ of @ patients ) , and @ % among patients with a prior null response ( @ of @ patients ) .", "sentence_id": 8}
+{"abstract_id": "24720679", "label": "results", "text": "Pruritus occurred more frequently with the active regimen ( in @ % of patients ) than with placebo ( @ % , P = @ ) .", "sentence_id": 9}
+{"abstract_id": "24720679", "label": "results", "text": "Three patients in the active-regimen group ( @ % ) discontinued the study drugs owing to adverse events .", "sentence_id": 10}
+{"abstract_id": "24720679", "label": "results", "text": "Hemoglobin values of grade @ ( @ to < @ g per deciliter ) and grade @ ( @ to < @ g per deciliter ) occurred in @ % and @ % of patients in the active-regimen group , respectively .", "sentence_id": 11}
+{"abstract_id": "24720679", "label": "conclusions", "text": "Rates of response to a @-week interferon-free combination regimen were more than @ % among previously treated patients with HCV genotype @ infection , including patients with a prior null response .", "sentence_id": 12}
+{"abstract_id": "24720679", "label": "conclusions", "text": "( Funded by AbbVie ; SAPPHIRE-II ClinicalTrials.gov number , NCT@ . )", "sentence_id": 13}