# Abstract

 

## Objectives: To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 µg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termination procedures. 

## Methods: This is a prospective, randomized clinical study in which we obtained informed consents from 146 women (fentanyl group: 76 [52.1%], paracetamol group: 70 [47.9%]) who were scheduled for suction curettage at the Istanbul Kanuni Sultan Suleyman Education and Training Hospital, Istanbul, Turkey in January 2015. Patients were randomly allocated into a fentanyl group or a paracetamol group. Visual analogue scores, modified Aldrete scores, and hemodynamic parameters were recorded during and after the surgical procedure. A record was also maintained of any adverse events. 

## Results: When the modified Aldrete scores at 60 minutes, systolic pressures at 0 minutes, oxygen saturation at 10, 15, 20 minutes, diastolic blood pressure at 10, 15, 20 minutes, heart rates, and visual analogue scores were compared, there was no significant difference between groups (p>0.05). In the fentanyl group, systolic blood pressures at 5, 10, 15, 20 minutes and diastolic blood pressure at 5 minutes and oxygen saturation at 5 minutes were significantly lower (p\<0.05). 

## Conclusion: Our study demonstrates that the analgesic properties and recovery profiles of intravenous paracetamol is as effective as fentanyl when used in suction termination procedures. Further larger studies are still required. # Results There were 146 patients involved in this study. When the demographic data, ASA and operation values of the 146 patients were compared (**[Figure 1](#)**), no significant differences were determined between groups (*p*>0.05) (**[Table 1](#)**). Also, no significant differences were found between the 2 groups in terms of VAS and modified Aldrete scores after 60 minutes (*p*>0.05) (**[Table 2](#)**). There was no significant difference in the HR between groups (*p*>0.05) (**[Figure 2](#)**). In the fentanyl group, systolic blood pressures at 5, 10, 15, and 20 minutes were significantly lower (*p*\<0.05) than in the paracetamol group; however, there was no difference between groups at 0 minutes (*p*>0.05) (**[Figure 3](#)**). Diastolic blood pressures at 5 minutes were significantly lower (*p*\<0.05) in the fentanyl group; however, there were no differences between groups at 10, 15 and 20 minutes (*p*>0.05) (**[Figure 4](#)**). In the fentanyl group, SpO~2~ at 5 minutes was significantly lower (*p*\<0.05) than in the paracetamol group, but there were no differences between groups at 10, 15, and 20 minutes (*p*>0.05) (**[Figure 5](#)**). No significant differences were found between groups with respect to side effects. <figure> <p><img src="" /></p> <figcaption>Flow diagram of 146 women who were scheduled for suction curettage. SBP - systolic blood pressure, DBP - diastolic blood pressure, HR - heart rates, VAS - visual analogue scale</figcaption> </figure> ::::table-wrap

::: caption
Visual analogue scale (VAS) and modified Aldrete scores of the patients
at 60th minutes (*p*>0.05).
:::

![](<>):::: <figure> <p><img src="" /></p> <figcaption>Heart rates of 146 women who were scheduled for suction curettage. min- minutes</figcaption> </figure> <figure> <p><img src="" /></p> <figcaption>Systolic blood pressures of 146 women who were scheduled for suction curettage. min- minutes</figcaption> </figure> <figure> <p><img src="" /></p> <figcaption>Diastolic blood pressures of 146 women who were scheduled for suction curettage. min- minutes</figcaption> </figure> <figure> <p><img src="" /></p> <figcaption>Oxygen saturation (SpO2) of 146 women who were scheduled for suction curettage. min- minutes</figcaption> </figure>


Extracted trial result:
Outcome: heart rates (continuous)
Intervention: fentanyl (1 µg/kg) and propofol
Comparator: paracetamol (20 mg/kg) and propofol
Intervention group size: 76
Comparator group size: 70
Notes: Means in figure 2's graphics.