Patient case: 45-year-old female with colon cancer; genetic feature: ERBB2 amplification

Clinical trial: Bevacizumab-containing Regimen for Metastatic Colorectal Cancer Failed to Cytotoxic Treatment

Summary: Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), combined with fluoropyrimidine-based chemotherapy is now the standard first and second-line treatment for metastatic colorectal cancer. The efficacy of bevacizumab with cytotoxic agents in the third-line treatment of patients with mCRC is still unknown.

Detailed description: This is a single arm, phase II, open-labelled clinical trial to evaluate the safety and efficacy of bevacizumab combined with cytotoxic agents in the treatment of patients with mCRC progressing under all available cytotoxic chemotherapy

Eligibility: Inclusion Criteria:
  -  Signed informed consent obtained.
  -  Subjects must be able to understand and willing to sign a written informed consent.
  -  Subjects > 18 years of age
  -  Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 2.
  -  Histological or cytological diagnosis of adenocarcinoma of the colon or rectum.
  -  Subjects have unresectable metastatic lesions.
  -  Subjects failed to respond to oxaliplatin, irinotecan and fluorouracil.
  -  Subjects have at least one measurable lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria measured within 4 weeks prior to registration.
  -  Leukocytes ≥ 3.0 x109/ L, absolute neutrophil count (ANC) ≥ 1.5 x109/ L, platelet count ≥ 100 x109/ L, hemoglobin (Hb) ≥ 9g/ dL.
  -  Total bilirubin ≤1.5 x the upper limit of normal (ULN).
  -  Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 x ULN.
  -  Amylase and lipase ≤ 1.5 x the ULN.
  -  Serum creatinine ≤ 1.5 x the ULN.
  -  Calculated creatinine clearance or 24 hour creatinine clearance ≥ 50 mL/ min.
  Exclusion Criteria:
  -  Any previous or concurrent cancer that is distinct in primary site or histology from colorectal cancer within 5 years prior to this study.
  -  Extended field radiotherapy within 4 weeks or limited field radiotherapy within 2 weeks prior to randomization.
  -  Major surgical procedure, open biopsy, or significant traumatic injury within 4 weeks before start of study medication.
  -  Uncontrolled hypertension. (systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management).
  -  Significant cardiovascular disease including unstable angina or myocardial infarction within 6 months before initiating study treatment or a history of ventricular arrhythmia
  -  Arterial or venous thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis or pulmonary embolism within the 6 months before start of study medication.
  -  Any evidence of active infection.
  -  Known history of human immunodeficiency virus (HIV) infection.
  -  History of bleeding diathesis or coagulopathy.
  -  History of interstitial pneumonitis or pulmonary fibrosis
  -  Pregnancy or lactation at the time of study entry.
  -  Any history of or currently known brain metastases.
  -  Known dihydropyrimidine dehydrogenase (DPD) deficiency
  -  Any illness or medical conditions that are unstable or could jeopardize the safety of the subjects and his/her compliance in the study.
  -  Subjects with known allergy to the study drugs or to any of its excipients.
  -  Current or recent (within 4 weeks prior to starting study treatment) treatment of another investigational drug or participation in another investigational study.

Relevance to patient case: not relevant