Patient case: 54-year-old male with malignant hyperthermia; genetic feature: RYR1

Clinical trial: Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Summary: Background:
  - High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney failure. It affects African Americans more than other racial groups. Data were collected from over a thousand African Americans across the country. The data were put into a database (MH-GRID). The data were about genes, diet, sleep, body mass index. They also cover stress and access to healthy foods and parks. Researchers at NIH will study these data in new ways. They want to learn more about the connection between African Americans and high blood pressure.
  Objective:
  - To study MH-GRID data to find the causes of severe high blood pressure and other cardio-metabolic problems in people of African ancestry.
  Eligibility:
  - African Americans age 30 55 with severe high blood pressure were used in the MH-GRID study. No new participants will be enrolled in this study.
  Design:
  - Researchers will examine data from the MH-GRID study.

Detailed description: The etiology of racial/ethnic differences in health involves dynamic interactions between
  genetic, behavioral and social-environmental determinants. Despite this, the field lacks robust
  datasets that integrate these determinants with clinical assessments in minority patient cohorts. The Minority Health Genomics and Translational Research Bio-repository Database (MHGRID) Network infrastructure facilitated the collection of biospecimens and related multidimensional data elements within a consortium of minority-serving clinics. This initiative expands the diversity of ancestral groups in national genomic medicine datasets and promises to accelerate the translation of personalized medicine into minority communities. The MH-GRID project was initiated by Dr. Gibbons (founding PI) prior to becoming an NIH investigator. The MH-GRID project has completed its participant recruitment activities, closed out its NIH funding and now represents an existing dataset and biorepository that is being transferred to NHGRI for ongoing secondary analyses. A variety of investigations will be conducted on this existing dataset. The primary outcome variables include severe hypertension and hypertension induced kidney damage. Secondary outcome variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening variables include genetics, behavioral (i.e. sleep quality, health literacy, smoking, diet, body mass index), ancestry, social (i.e. socioeconomic status, racial discrimination, stress, social depreivation), biological (i.e. insulin resistance, cholesterol, inflammatory markers), and environmental (i.e. neighborhood, access to healthy foods, parks).

Eligibility: -  INCLUSION CRITERIA:
  -  The MH-GRID Project s inclusion criteria included AA age 30-55 years
  -  Severe controlled HTN or severe resistant HTN.
  EXCLUSION CRITERIA:
  -  Exclusion criteria involved patients with secondary forms of HTN, primary forms of kidney disease or major co-morbidities (e.g. diabetes, heart failure, end-stage renal failure, HIV, and liver disease).
  -  Children <18 were not enrolled in the protocol.

Relevance to patient case: not relevant