Patient case: 36-year-old female with Brugada syndrome; genetic feature: SCN5A

Clinical trial: Blinatumomab in Adult Patients With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia

Summary: This study is designed to confirm the efficacy, safety, and tolerability of blinatumomab in patients with MRD of B- precursor ALL in complete hematological remission including patients with relapse after SCT. The study aims to expand experience generated in previous trials in patients with MRD positive ALL with a focus on additional specific questions.

Detailed description: Transfer of patients to alloHSCT after one cycle or after subsequent cycles is considered as per protocol discontinuation and as premature treatment discontinuation In case of hematological or extramedullary relapse, the study treatment will be permanently discontinued.
  There will be a safety follow-up visit at 30 days after end of the last infusion. There will be efficacy follow-up until 18 months after treatment start. In patients scheduled for SCT the 30-day safety-visit may be performed at the latest time point possible before initiation of subsequent treatment.

Eligibility: Inclusion Criteria:
  1. Patients with CD19 positive B-precursor ALL in complete hematological remission defined as less than 5% blasts in bone marrow after at least three intense chemotherapy blocks (e.g., GMALL induction I-II/consolidation I).
  2. Presence of minimal residual disease (MRD) at a level of ≥10-4 (molecular failure or molecular relapse) in an assay with a minimum sensitivity of 10-4 documented after an interval of at least 2 weeks from last systemic chemotherapy
  3. For evaluation of MRD patients must have at least one molecular marker based on individual rearrangements of immunoglobulin, TCR-genes or other suitable genes evaluated by the reference laboratory of the trial
  4. Bone marrow function as defined below:
  -  ANC (Neutrophils) >= 1,000/µL
  -  Platelets >= 50,000/µL (transfusion permitted)
  -  HB level >= 9g/dl (transfusion permitted)
  5. Renal and hepatic function as defined below:
  -  AST (GOT), ALT (GPT), and AP < 5 x upper limit of normal (ULN)
  -  Total bilirubin < 1.5 x ULN (unless related to Gilbert's Meulengracht disease)
  -  Creatinine < 1.5x ULN
  -  Creatinine clearance >= 60 mL/min (e.g. calculated according Cockroft&Gault)
  6. Negative HIV test, negative hepatitis B (HbsAg) and hepatitis C virus (anti-HCV) test
  7. Negative pregnancy test in women of childbearing potential
  8. ECOG Performance Status 0 or 1
  9. Age >=18 years
  10. Ability to understand and willingness to sign a written informed consent
  11. Signed and dated written informed consent is available
  12. Participation in the registry of the German Multicenter Study Group for Adult ALL (GMALL)
  Exclusion Criteria:
  1. Ph/BCR-ABL positive ALL
  2. Presence of circulating blasts or current extramedullary involvement by ALL
  3. History or presence of clinically relevant CNS pathology (e.g. seizure, paresis, aphasia, cerebrovascular ischemia/hemorrhage, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome or psychosis)
  4. Current detection of ALL blast cells in cerebro-spinal fluid
  5. History of or active relevant autoimmune disease
  6. Systemic cancer chemotherapy within 2 weeks prior to study treatment (except for intrathecal prophylaxis)
  7. Radiotherapy within 4 weeks prior to study treatment
  8. Live vaccination within 2 weeks before the start of study treatment
  9. Autologous hematopoietic stem cell transplantation (SCT) within six weeks prior to study treatment
  10. Allogeneic SCT within 12 weeks before the start of study treatment
  11. Any active acute Graft-versus-Host Disease (GvHD), grade 2-4 according to the Glucksberg criteria or active chronic GvHD requiring systemic treatment
  12. Any systemic therapy against GvHD within 2 weeks before start of study treatment
  13. Therapy with monoclonal antibodies (rituximab, alemtuzumab) within 4 weeks prior to study treatment
  14. Treatment with any investigational product within four weeks prior to study treatment
  15. Previous treatment with blinatumomab or other anti-CD19-therapy
  16. Known hypersensitivity to immunoglobulins or to any other component of the study drug formulation
  17. History of malignancy other than ALL diagnosed within 5 years prior to start of protocol-specified therapy with the exception of:
  -  Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
  -  Adequately treated cervical carcinoma in situ without evidence of disease
  -  Adequately treated breast ductal carcinoma in situ without evidence of disease
  -  Prostatic intraepithelial neoplasia without evidence of prostate cancer
  18. Active infection, any other concurrent disease or medical condition that are deemed to interfere with the conduct of the study as judged by the investigator
  19. Nursing women
  20. Woman of childbearing potential and is not willing to use 2 highly effective methods of contraception while receiving study treatment and for an additional 3 months after the last dose of study treatment.
  21. Male who has a female partner of childbearing potential, and is not willing to use 2 highly effective forms of contraception while receiving study treatment and for at least an additional 3 months after the last dose of study treatment

Relevance to patient case: not relevant