Patient case: 32-year-old female with inflammatory myofibroblastic tumor; genetic feature: RANBP2-ALK fusion

Clinical trial: Phase I Study of Chiauranib in Patients With Advanced Solid Tumors

Summary: The purpose of this dose-escalation study is to assess the safety and tolerability of treatment with Chiauranib administered orally over a range of doses in patients with advanced solid tumors.

Detailed description: The purpose of this study is to assess the tolerability and safety include adverse events, vital signs, laboratory tests ,etc., of a range of doses of Chiauranib in solid tumor patients, and to determine the dose limit toxicity and the maximum tolerable dose.

Eligibility: Inclusion Criteria:
  1. Histological or cytological confirmation of advanced solid tumor, including non-small cell lung cancer, colorectal cancer, ovarian cancer, renal cell carcinoma, gastrointestinal stromal tumor, gastric cancer, et al;
  2. Patients with advanced solid tumors refractory to standard therapy or for which no standard therapy exists;
  3. Body mass index (BMI) is between 18 and 28;
  4. Age: 18~65 years;
  5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1;
  6. Laboratory criteria are as follows:
  1. Complete blood count: hemoglobin (Hb) ≥100g/L (no blood transfusion within 14 days); absolute neutrophil count (ANC) ≥1.5×109/L ; platelets >=100×109/L
  2. Biochemistry test: serum creatinine <=1.5×upper limit of normal (ULN); total bilirubin≦1.5×ULN; alanine aminotransferase / aspartate aminotransferase≦1.5×ULN; fasting triglyceride (TG) <= 3.0 mmol/L; total cholesterol <= 7.75 mmol/L
  3. Coagulation test: International Normalized Ratio (INR) < 1.5
  7. Women of child-bearing potential should be non-lactating patients, and must agree to use effective contraceptive methods prior to study entry, during study participation, and up to 6 months following completion of therapy. A serum or urine pregnancy test within 7 days before enrollment must be negative; Men must agree to use effective contraceptive methods during study participation and up to 6 months following completion of therapy;
  8. Willingness to sign a written informed consent document
  Exclusion Criteria:
  1. Life expectation < 3 months;
  2. Subjects received anti-cancer therapy (including chemotherapy, radiotherapy, targeted therapy and endocrine therapy, et al) within 4 weeks prior to study entry; Subjects received nitrosoureas or mitomycin chemotherapy within 6 weeks prior to study entry;
  3. Have uncontrolled or significant cardiovascular disease, including:
  1. Myocardial infarction (< the last 12 months)
  2. Uncontrolled angina (< the last 6 months)
  3. Congestive heart failure (< the last 6 months), or Left Ventricular Ejection Fraction (LVEF) < 50% prior to study entry
  4. History of any significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or TdP)
  5. History of significant QT interval prolongation, or Corrected QT Interval (QTc) > 450 ms prior to study entry
  6. History of cerebrovascular accident
  7. Symptomatic coronary heart disease requiring treatment with agents
  8. Uncontrolled hypertension (> 140/90 mmHg) by single agent;
  4. Have active bleeding , current thrombotic disease, or patients with bleeding potential receiving anticoagulation therapy;
  5. History of deep vein thrombosis or pulmonary embolism;
  6. Have unsolved toxicities (> grade 1) from prior anti-cancer therapy;
  7. Have clinical significant gastrointestinal abnormality, e.g., unable to swallow, chronic diarrhea, ileus, that would impair the ingestion,transportation or absorption of oral agents, or patients undergone gastrectomy;
  8. Have symptomatic brain metastasis;
  9. History of organ transplantation;
  10. Proteinuria positive;
  11. Congenital or acquired immunodeficiency, active infections;
  12. Any mental or cognitive disorder, that would impair the ability to understand the informed consent document or the operation and compliance of study;
  13. Any other condition which is inappropriate for the study in the opinion of the investigators.

Relevance to patient case: not relevant