Patient case: 60-year-old female with gastric cancer; genetic feature: EGFR

Clinical trial: Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Local Advanced Gastric Cancer

Summary: Gastric cancer is the leading cause of death from a intestinal tract cancer in China.In most cases, the high death rate is due to tumor that has spread beyond the gastric cancer at the time of diagnosis. In China, the standard chemotherapy for the initial treatment of gastric cancer is a combination of a platinum analogue with 5-Fu.With modern surgical interventions and contemporary chemotherapy, most patients attain better clinical remission.The majority of them, however, will eventually have a relapse and die of the disease.
  The peritoneal cavity is the principal site of disease in gastric cancer.Although the intensity of intravenous chemotherapy is limited mainly by myelotoxicity, several active drugs can be administered directly into the peritoneal cavity. The rationale for intraperitoneal therapy in gastric cancer is that the peritoneum, the predominant site of tumor, receives sustained exposure to high concentrations of antitumor agents while normal tissues, such as the bone marrow, are relatively spared.
  The investigators conducted this trial to investigate the efficacy and safety of intraperitoneal chemotherapy in advanced gastric cancer.

Detailed description: To investigate efficacy and safety of intraperitoneal chemotherapy as part of adjuvant treatment for advanced gastric cancer.

Eligibility: Inclusion Criteria:
  DISEASE CHARACTERISTICS
  -  Histologically confirmed primary adenocarcinoma of the stomach
  -  3-4weeks after radical operation for gastric cancer
  -  Stage of the gastric cancer was T3-4NxM0
  PATIENT CHARACTERISTICS:
  -  Age: 18 - 70years old
  Life expectancy:
  -  Longer than 3 months
  Hematopoietic:
  -  Granulocyte count at least 1,500/mm3
  -  Platelet count at least 100,000/mm3
  -  Hemoglobin at least 80*10^12/mm3
  Hepatic:
  - AST no greater than 2.5 times ULN
  Renal:
  -  Creatinine no greater than 1.5 times ULN
  Other:
  -  Fertile patients must use effective contraception
  PRIOR CONCURRENT THERAPY:
  Biologic therapy:
  -  Not specified
  Chemotherapy:
  -  Prior chemotherapy and radiotherapy were not allowed
  -  No other concurrent chemotherapy
  Radiotherapy:
  -  Locally radiotherapy for local disease of advanced gastric cancer during adjuvant treatment was allowed
  Surgery:
  -  See Disease Characteristics
  -  Prior surgery for gastric cancer was necessary
  Exclusion Criteria:
  -  Haven't recovery from operation or complication of operation
  -  With the following risk factors: Uncontrolled or severe cardiovascular disease (e.g., myocardial infarction within the past 6 months, congestive heart failure treated with medications, or uncontrolled hypertension)
  -  Pregnant or nursing
  -  Other currently active malignancy except nonmelanoma skin cancer
  -  Uncontrolled or severe bleeding,diarrhea,intestinal obstruction,adhesion of intestine
  -  metastasis before enrollment
  -  Received other chemotherapy or radiotherapy after operation

Relevance to patient case: not relevant