Patient case: 49-year-old male with colorectal cancer; genetic feature: NRAS

Clinical trial: Personalized Screening Plans to Increase Colorectal Cancer Screening in Healthy Participants

Summary: RATIONALE: Developing a personalized screening plan may be more effective than usual care in increasing the number of healthy participants who regularly undergo screening for colorectal cancer.
  PURPOSE: This randomized phase III trial is studying personalized screening plans to see how well they work compared with usual care in increasing colorectal cancer screening in healthy participants.

Detailed description: OBJECTIVES:
  -  To compare the impact of tailored intervention vs standard intervention vs usual care on patient utilization of colorectal cancer (CRC) screening.
  -  To compare the impact of these interventions on CRC screening preference.
  -  To compare the impact of these interventions on patient perceptions about CRC screening.
  OUTLINE: This is a multicenter study. Participants are stratified by practice and study wave and blocking. Participants are randomized to 1 of 3 arms.
  -  Arm I (usual care): Participants receive usual care in accordance with their normal patterns of interaction with study practices.
  -  Arm II (standard intervention [SI]): A generic screening invitation letter, a colorectal cancer (CRC) screening informational booklet, stool blood testing (SBT) cards, and instructions for arranging a colonoscopy screening appointment are mailed to participants on day 15. On day 45, a reminder letter is mailed to participants who have not completed SBT or undergone a screening colonoscopy.
  -  Arm III (tailored navigation intervention [TNI]): A test-specific screening invitation letter, a CRC screening informational booklet, and additional test-specific materials (i.e., instructions for arranging a colonoscopy screening appointment or SBT cards) are mailed to participants on day 15. On day 30, a patient navigator contacts participants by telephone who have not completed SBT or undergone a screening colonoscopy. The patient navigator re-assesses screening test-specific decision stage; addresses CRC screening barriers; develops a personalized CRC screening plan to move the participant towards screening use (i.e., explains the steps in completing the SBT or scheduling a colonoscopy appointment); and facilitates screening plan implementation. On day 45, a reminder letter is mailed to participants who were contacted by the navigator.
  Participants in all arms complete a survey at baseline and then at 6 months. Medical records for each participant are reviewed at 6 months.

Eligibility: DISEASE CHARACTERISTICS:
  -  Meets the following criteria:
  -  No personal history of colorectal neoplasia (cancer or polyps) or inflammatory bowel disease
  -  No family history of colorectal cancer (CRC) diagnosed before the age of 60
  -  Visited one of the six community-based primary care practices that are part of the Christiana Care Health System (CCHS) in Delaware within the past 2 years
  -  Not up-to-date with CRC screening, according to the United States Preventive Services Task Force guidelines
  PATIENT CHARACTERISTICS:
  -  Must have a complete address and telephone number
  -  Able to communicate in English
  -  No psychosis or severe dementia
  PRIOR CONCURRENT THERAPY:
  -  No prior participation in the developmental study CA10241

Relevance to patient case: not relevant