Patient case: 86-year-old female with melanoma; genetic feature: high tumor mutational burden

Clinical trial: BRIEF Bendamustine and Rituximab In Elderly Follicular

Summary: The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular lymphoma, with an intermediate or high FLIPI score and without high tumor burden.
  This short induction is followed by a rituximab (375mg/m2)maintenance/ Induction schedule:Rituximab+Bendamustine on Day 1, Bendamustine on Day 2, Rituximab on Day 8, Rituximab on Day 15, rituximab on day 22, Bendamustine on Day 29, Bendamustine on Day 30 Maintenance schedule: 12 infusions of rituximab, each 8 weeks


Eligibility: Inclusion Criteria:
  -  Histologically confirmed follicular lymphoma CD20+, all grades except the grade 3b with a lymph node biopsy performed within 6 months before study entry and with material available for central review
  -  A minimal initial immunology is required, including : CD20, bcl-2, CD10 and CD5
  -  Age must be ≥ 60 years
  -  Patients not previously treated
  -  Patients with an intermediate or high risk FLIPI score requiring 2 or more of the following adverse prognostic factors:
  1. Age >60 ans
  2. Ann Arbor Stage (III-IV vs. I-II)
  3. Hemoglobin level ( < 12g/dL vs. ≥ 12 g/dL)
  4. Number of nodal areas (< 5 vs. ≥ 5) (Note: LDH should not be considered as an adverse prognostic factor in this study since it is considered as high tumor burden in the GELF criteria)
  -  Low burden disease at study entry according to the GELF criteria
  -  Patients with at least one measurable site of disease: patients with only blood or marrow or splenic infiltration are excluded
  -  Performance status ≤ 2 on the ECOG scale
  -  Adequate hematological function (unless abnormalities are related to lymphoma infiltration of the bone marrow) including:
  -  Hemoglobin ≥ 8.0 g/dL (5.0 mmol/L)
  -  Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
  -  Platelet count ≥ 100 x 109/L
  -  Adequate renal function: calculated creatinine clearance > 50 ml/min (according to MDRD method) unless these abnormalities are related to lymphoma
  -  Adequate hepatic function: Total bilirubin < 2.0 mg/dl (34 µmol/L), AST (SGOT) and ALT (SGPT) ≤ 2.5 x the upper limit of normal unless these abnormalities are related to lymphoma
  -  Adequate cardiac function: LEVF ≥ 50% calculated by echocardiography or scintigraphy
  -  Having previously signed a written informed consent
  Exclusion Criteria:
  -  Other histological types of lymphoma than follicular lymphoma
  -  Grade 3b follicular lymphoma
  -  Patients previously on watch and wait since more than 6 months from diagnosis
  -  Patients previously treated for lymphoma, except splenectomy
  -  Patients with low FLIPI score (0 or 1 adverse prognostic factors not considering elevated LDH)
  -  Bulky disease at study entry according to the GELF criteria
  -  Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis)
  -  Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer or previous cancer in CR without any treatment in the last 5 years
  -  Positive HIV, HBV (anti-HBc positivity) and HCV serologies before inclusion
  -  Poor Performance status > 2 on the ECOG scale
  -  Known contra-indication to study product
  -  Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease).
  -  Any other co-existing medical or psychological condition that will preclude participation in the study or compromise ability to give informed consent.

Relevance to patient case: not relevant