Patient case: 1-year-old male with acute myeloid leukemia; genetic feature: IDH1

Clinical trial: Allogeneic Stem Cell Transplantation Followed By Targeted Immune Therapy In Average Risk Leukemia

Summary: Allogeneic stem cell transplantation (AlloSCT) followed by targeted immune therapy Gemtuzumab Ozogamicin patients with acute myeloid leukemia (AML)/juvenile myelomonocytic leukemia (JMML)/myelodysplastic syndromes (MDS) will be safe and well tolerated.

Detailed description: Gemtuzumab Ozogamicin (CMA-676) is a chemotherapeutic agent consisting of a recombinant humanized anti-CD33 antibody conjugated with calicheamicin, a highly potent cytotoxic antitumor antibiotic. The antibody portion of Gemtuzumab binds specifically to the CD33 antigen, a sialic acid-dependent adhesion protein expressed on the surface of leukemic blasts, normal and leukemic myeloid colony-forming cells, including leukemic clonogenic precursors, but excluding pluripotent hematopoietic stem cells and nonhematopoietic cells. This results in formation of a complex that is internalized, upon which the calicheamicin derivative is released within the lysosomes of the myeloid cell. The free calicheamicin derivative then binds to deoxyribonucleic acid (DNA), resulting in DNA double strand breaks and consequential cell death. Over 80% of AML patients possess myeloid blast cells with CD33 surface antigen expression.

Eligibility: Inclusion Criteria:
  Disease Status
  -  AML 1st CR with a matched family donor (excluding Downs Syndrome, APL, poor cytogenetics [12p, 5q, -7 and FLT3 mutations or duplication t(9;11) and others]) and patients consented to and registered on an upfront AML COG study with a matched family donor)
  -  AML 1st CR [excluding Downs Syndrome, APL, and chromosome translocation (8;21) or inversion (16) or poor cytogenetics (12p, 5q, -7, FLT3 mutation or duplication t(9;11) and others)] with unrelated donor
  -  AML 2nd CR
  -  Myelodysplastic Syndrome (MDS) and ≤ 5% bone marrow myeloblasts at diagnosis (de novo patients only)
  -  Juvenile Myelomonocytic Leukemia (JMML) and ≤ 5% bone marrow myeloblasts at diagnosis
  In regards to disease immunophenotype, disease must express a minimum of ≥10% CD33 positivity for patients with AML
  Organ Function:
  Patients must have adequate organ function as defined below:
  Adequate renal function defined as:
  -  Serum creatinine < 1.5 x normal, or
  -  Creatinine clearance or radioisotope glomerular filtration rate (GFR) 40 ml/min/m2 or > 60 ml/min/1.73 m2 or an equivalent GFR as determined by the institutional normal range
  Adequate liver function defined as total bilirubin 2.0 x upper limit of normal (ULN), or serum glutamic-oxaloacetic transaminase (SGOT)(aspartate aminotransferase (AST)) or serum glutamic-pyruvic transaminase (SGPT)(alanine aminotransferase (ALT)) < 5.0 xULN
  Adequate cardiac function defined as:
  -  Shortening fraction of ≥ 25% by echocardiogram, or
  -  Ejection fraction of ≥ 45% by radionuclide angiogram or echocardiogram
  Adequate pulmonary function defined as:
  -  Diffusion capacity of the lung for carbon monoxide (DLCO) ≥ 40% by pulmonary function tests (PFT) (Uncorrected)
  -  For children who are uncooperative, no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% on room air
  Exclusion Criteria:
  -  Patients with active central nervous system (CNS) AML/JMML disease at time of preparative regimen
  -  Secondary MDS
  -  Poor cytogenetics (12p, 5q, -7, FLT3 mutation or duplication)
  -  Female patients who are pregnant (positive human chorionic gonadotropin(hCG))
  -  Karnofsky <70% or Lansky <50% if 10 years or less
  -  Age >30 years
  -  Seropositive for Human Immunodeficiency Virus (HIV)
  -  Patients consented to and registered on an upfront Children's Oncology Group (COG) AML study with a matched family donor

Relevance to patient case: not relevant