Patient case: 74-year-old female with melanoma; genetic feature: no tumor infiltrating lymphocytes

Clinical trial: Temozolomide, Thalidomide, and Lomustine in Treating Patients With Unresectable Stage III or Stage IV Melanoma

Summary: RATIONALE: Drugs used in chemotherapy, such as temozolomide and lomustine, use different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Combining temozolomide and thalidomide with lomustine may kill more tumor cells.
  PURPOSE: Phase II trial to study the effectiveness of combining temozolomide and thalidomide with lomustine in treating patients who have unresectable stage III or stage IV melanoma.

Detailed description: OBJECTIVES:
  Primary
  -  Determine the antitumor activity of temozolomide, thalidomide, and lomustine, in terms of objective response rate, in patients with unresectable stage III or stage IV melanoma.
  Secondary
  -  Determine the toxicity profile of this regimen in these patients.
  -  Determine the duration of response and overall survival of patients treated with this regimen.
  OUTLINE: Patients receive oral temozolomide on days 1-42, oral thalidomide on days 1-56, and oral lomustine on days 1 and 29. Courses repeat every 8 weeks in the absence of disease progression or unacceptable toxicity.
  Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
  PROJECTED ACCRUAL: A total of 12-35 patients will be accrued for this study within 2 years.

Eligibility: DISEASE CHARACTERISTICS:
  -  Histologically confirmed metastatic malignant melanoma
  -  Unresectable stage III OR stage IV disease
  -  Ocular, mucosal, and cutaneous melanoma allowed
  -  Measurable disease
  -  Indicator lesions within a prior radiotherapy field must have recent evidence of disease progression
  -  Indicator lesions must be distinct from the surgical and/or radiation changes induced by prior local therapies
  -  No more than 2 symptomatic hemorrhagic lesions in the brain
  -  No hemorrhagic lesion(s) greater than 1 cm in diameter
  PATIENT CHARACTERISTICS:
  Age
  -  18 and over
  Performance status
  -  Karnofsky 80-100%
  Life expectancy
  -  Not specified
  Hematopoietic
  -  Absolute granulocyte count at least 1,500/mm^3
  -  Platelet count at least 100,000/mm^3
  Hepatic
  -  Bilirubin no greater than 2 times upper limit of normal (ULN)
  -  SGOT and SGPT no greater than 2 times ULN
  -  Alkaline phosphatase no greater than 2 times ULN
  -  Lactic dehydrogenase no greater than 2 times ULN
  Renal
  -  Creatinine no greater than 2 mg/dL
  Cardiovascular
  -  No history of severe cardiovascular disease
  -  No myocardial infarction within the past 6 months
  -  No unstable angina
  -  No New York Heart Association class III or IV congestive heart failure
  -  No ventricular arrhythmia
  -  No uncontrolled arrhythmia
  Gastrointestinal
  -  No frequent vomiting
  -  No other medical condition that would preclude oral medication intake (e.g., partial bowel obstruction)
  Other
  -  Not pregnant or nursing
  -  Negative pregnancy test
  -  Fertile patients must use effective barrier contraception during and for 4 weeks after study participation
  -  HIV negative
  -  No AIDS-related illness
  -  No serious infection requiring IV antibiotics
  -  No other uncontrolled medical illness that would preclude study participation
  -  No other malignancy within the past 2 years except nonmelanoma skin cancer, carcinoma in situ of the cervix, or T1a or b prostate cancer meeting all of the following criteria:
  -  Detected incidentally at transurethral resection of the prostate (TURP)
  -  Comprises less than 5% of resected tissue
  -  Prostate-specific antigen normal since TURP
  PRIOR CONCURRENT THERAPY:
  Biologic therapy
  -  At least 3 weeks since prior immunotherapy or biologic therapy
  -  No concurrent immunotherapy
  Chemotherapy
  -  No prior systemic chemotherapy for melanoma
  -  No other concurrent chemotherapy
  Endocrine therapy
  -  Not specified
  Radiotherapy
  -  See Disease Characteristics
  -  At least 3 weeks since prior focused radiotherapy for brain metastases
  -  At least 3 weeks since prior radiosurgery
  -  At least 4 weeks since prior whole brain radiotherapy
  -  At least 3 weeks since prior interstitial brachytherapy
  -  No concurrent radiotherapy
  Surgery
  -  See Disease Characteristics
  -  At least 3 weeks since prior surgery for brain metastases
  -  At least 3 weeks since prior surgery requiring general anesthesia
  Other
  -  Recovered from all prior therapies

Relevance to patient case: not relevant