Patient case: 45-year-old female with medullary thyroid carcinoma; genetic feature: RET

Clinical trial: Study of CGX1321 in Subjects With Advanced Solid Tumors

Summary: This is a multicenter, open-label, Phase 1 study consisting of a Dose Escalation Phase and a Dose Expansion Phase to evaluate safety, pharmacokinetics, and clinical activity.

Detailed description: The purpose of the Dose Escalation Phase is to examine the safety and determine the maximum tolerated dose of CGX1321 when administered to subjects with advanced solid tumors including GI tumors that have relapsed or are refractory to or not considered medically suitable to receive standard of care treatment who meet the entry criteria.
  Once the dose is identified in the Dose Escalation Phase, the Dose Expansion Phase will start. The purpose of the Dose Expansion Phase is to continue to examine the safety and confirm the final Phase 2 dose of CGX1321 when administered to subjects with advanced GI tumors who meet the entry criteria.

Eligibility: Inclusion Criteria:
  Subjects must meet all of the following criteria to be eligible for the study:
  -  Pathologically-confirmed, locally advanced or metastatic solid tumors that have relapsed or are refractory to or are not considered medically suitable to receive standard of care treatment (Dose Escalation Phase)
  -  Histologically-diagnosed, advanced Gl tumors, such as colorectal adenocarcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma, bile duct carcinoma, hepatocellular carcinoma, esophageal carcinoma that have relapsed or are refractory to or are not considered medically suitable to receive standard of care treatment (Dose Expansion Phase)
  -  Eastern Cooperative Oncology Group score of 0 - 2
  -  Minimum life expectancy of 3 months
  -  Age 18 years or older
  -  Adequate organ function
  -  Recovery from prior treatment-related toxicities
  -  Ability to swallow tablets
  -  Willingness for patients of reproductive potential to use adequate methods of contraception during and for 3 months after study treatment
  Exclusion Criteria:
  -  Prior exposure to a WNT inhibitor
  -  Received previous therapy for malignancy within 21 days
  -  Major surgery within 4 weeks of first dose of study drug
  -  Radiotherapy within 2 weeks of first dose of study drug
  -  Bleeding disorder
  -  Bone abnormalities
  -  Uncontrolled central nervous system metastases or leptomeningeal metastases
  -  Requirement for immunosuppressive agents (must be off for at least 7 days)
  -  Currently receiving medications known to be inhibitors of CYP3A4/5. Subjects currently receiving medications of known inducers of CYP3A4/5 or substrates of CYP2C8/9 and CYP1A2 may be excluded.
  -  Cardiac abnormalities
  -  Known human immunodeficiency virus positive, or active hepatitis A, B or C
  -  History of additional prior malignancy with the exception of surgically cured carcinomas such as skin, prostate, bladder, thyroid, cervix or other carcinomas in situ
  -  Active systemic infection requiring intravenous antibiotics within 2 weeks of treatment start
  -  GI impairment that may compromise absorption of study drug
  -  Pregnancy or lactation

Relevance to patient case: not relevant