Patient case: 86-year-old female with melanoma; genetic feature: high tumor mutational burden

Clinical trial: A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) in Subjects With Selected Cancers (INCB 24360-202 / MK-3475-037 / KEYNOTE-037/ ECHO-202)

Summary: The purpose of this study is to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in subjects with certain cancers. This study will be conducted in 2 phases, Phase 1 and Phase 2.


Eligibility: Inclusion Criteria:
  -  Subjects with histologically or cytologically NSCLC, melanoma, transitional cell carcinoma of the GU tract, renal cell cancer, triple negative breast cancer, adenocarcinoma of the endometrium or squamous cell carcinoma of the head and neck (Phase 1)
  -  Subjects with histologically confirmed melanoma, NSCLC, transitional cell carcinoma of the GU tract, TNBC, SCCHN, ovarian cancer, MSI high CRC, RCC and DLBCL (Phase 2)
  -  Life expectancy > 12 weeks.
  -  Eastern Cooperative Oncology Group (ECOG) performance status 0 - 1.
  -  Presence of measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or Lugano Classification for subjects with DLBCL.
  -  Laboratory and medical history parameters within protocol-defined range.
  -  For Phase 1: Subjects who have advanced or metastatic disease as noted above that have received at least one prior therapy or have advanced or metastatic disease for which no curative treatment is available may be enrolled.
  -  For Phase 2 expansion cohorts: Subjects with NSCLC, melanoma, transitional cell carcinoma of the GU tract, SCCHN, ovarian cancer, MSI high CRC, RCC, DLBCL, and TNBC.
  -  Phase 2 expansion: NSCLC
  -  Subjects who have received at least 1 prior platinum-based therapy. Subjects who have a non-platinum-based regimen may be enrolled with medical monitor approval.
  -  Tumors with epidermal growth factor receptor mutation positive or anaplastic lymphoma kinase fusion oncogene positive treated with a tyrosine kinase inhibitor are permitted; however, subjects should have progressed on or be intolerant to the targeted therapy.
  -  Subjects must not have received immunotherapy with PD-1 or CTLA-4 targeted therapy.
  -  Phase 2 expansion: Melanoma
  -  Documentation of V600E-activating BRAF mutation status
  -  Subjects must not have received immunotherapy with anti-PD-1, anti-PD-L1, or anti-CTLA-4 therapy. Exception: Prior anti−CTLA-4 in the adjuvant setting would be permitted.
  -  Ocular melanoma is excluded.
  -  Phase 2 expansion: Transitional cell carcinoma of the GU tract
  -  Metastatic or locally advanced and not amenable to curative therapy with disease progression on or after platinum-based chemotherapy or alternative therapy if platinum-based therapy is not appropriate.
  -  Prior PD-1 or CTLA-4 targeted therapies are excluded
  -  Phase 2 expansion: SCCHN
  -  Histologically confirmed metastatic or recurrent squamous cell carcinoma not amenable to local therapy with curative intent (surgery or radiation with or without chemotherapy). Carcinoma of the nasopharynx, salivary gland, or nonsquamous histologies are excluded.
  -  Subjects must have received at least 1 prior systemic chemotherapy regimen that must have included a platinum-based therapy.
  -  Prior PD-1 or CTLA-4 targeted therapies are excluded.
  -  Phase 2 expansion: Ovarian cancer
  -  Subjects with FIGO Stage Ic, Stage II, Stage III, Stage IV, recurrent, or persistent (unresectable) histologically confirmed epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube carcinoma.
  -  Subjects must have received a platinum-taxane-based regimen as first-line therapy.
  -  Prior PD-1 or CTLA-4 targeted therapies are excluded.
  -  Borderline, low-malignant-potential epithelial carcinoma per histopathology is excluded.
  -  Phase 2 expansion: Relapsed or refractory DLBCL
  -  Prior allogeneic stem-cell transplantation is excluded.
  -  Must have received > or = 1 prior treatment regimen.
  -  Not a candidate for curative therapy or hematopoietic stem-cell transplantation (either due to disease burden, fitness, or preference).
  -  Prior PD-1 or CTLA-4 targeted therapies are excluded.
  -  Phase 2 expansion: TNBC
  -  Histologically confirmed breast adenocarcinoma that is unresectable loco regional, or metastatic
  -  Pathologically confirmed as triple negative, source documented, defined as both of the following:
  -  Estrogen receptor (ER) and progesterone receptor (PgR) negative
  -  Human epidermal growth factor receptor 2 (HER2) negative as per American Society of Clinical Oncology/College of American Pathologists guidelines
  -  Subject must have received at least 1 prior systemic regimen for advanced or metastatic disease
  -  Prior PD-1 or CTLA-4 targeted therapies are excluded.
  -  Phase 2 expansion: RCC
  -  Subjects with histological or cytological confirmation of clear cell RCC.
  -  Not curable by surgery.
  -  Subjects must have received prior antiangiogenic therapy
  -  Subjects must not have received prior immunotherapy with anti-PD-1, anti-PD-L1, or anti-CTLA-4 therapy
  -  Phase 2 expansion: MSI high CRC
  -  Subjects with histological confirmation of locally advanced unresectable or metastatic MSI high CRC
  -  MSI status is, respectively, determined by examining CRC tumor
  -  Tumor biopsies are required. If a subject has inaccessible lesions, such as in ovarian cancer, or highly vascular lesions, such as RCC, enrollment may be considered with medical monitor approval, and archived tissue may be acceptable.
  -  Females of child-bearing potential and males who use adequate birth control through 120 days post dose.
  Exclusion Criteria:
  • Subjects who participated in any other study in which receipt of an investigational study drug or device occurred within 28 days or 5 half-lives (whichever is longer) prior to first dose.
  Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including ipilimumab or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways). Exception: Prior anti−CTLA-4 in the adjuvant setting for subjects with melanoma would be permitted.
  -  Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Subjects with previously treated brain metastases may participate provided they are stable.
  -  Has an active autoimmune disease.
  -  Has evidence of interstitial lung disease or pneumonitis.
  -  Live vaccine use within 30 days of first dose of study medication
  -  Monoamine oxidase inhibitors

Relevance to patient case: not relevant