Patient case: 54-year-old male with Pancreatic cancer. Genetic variant: CDKN2A. Other conditions: Diabetes, Hypertension.

Clinical trial: Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced Cancer

Summary: It is a non-randomized, multicentric, cohort study, combined with a biological sample collection, a retrospective clinical data collection and with a genetic and immunologic biomarkers study.
  The ProfiLER program aims to implement a personalized cancer medicine approach by proposing to establish the genetic and immunologic profile of the tumor for patients with an advanced malignant tumor, in order to define a map of genetic (for the pre-identified target genes) and immunologic profiles for all the studied types of cancer. This study will also allow adapting the therapeutic management of these patients, if needed, by giving them targeted therapies or immunotherapies (commercialized on in ongoing clinical trials), based on the recommendations of the multidisciplinary molecular board.
  The genetic and immunologic profile of the tumor will be determined from archival or fresh collected (biopsy of a reachable lesion) tumor sample and from a blood sample. The correlation between genetic profiles of the tumor, patients immunity status and retrospective clinical data (progression, tumor response, etc.) collected from the patient medical records will probably allow us to identify biomarkers with a potential predictive value and to determine if some genetic disorders are linked to immunity status alterations.

Detailed description: Determination of the tumor profile and review in multidisciplinary molecular board:
  The genetic and immunologic profile will be performed from the available tumor sample and from a blood sample.
  Genetic profile:
  -  Research of mutations/insertions/deletions for an array of predefined genes in tumor deoxyribonucleic acid by high-throughput sequencing
  -  Analysis of copy number variations of genes on tumor deoxyribonucleic acid by microarray-based comparative genomic hybridization
  -  Analysis of rearrangements involving the gene Anaplastic Lymphoma Kinase that can't be detected by Next Generation Sequencing or array Comparative Genomic Hybridization (balanced translocations) by means of fluorescent hybridization probes on tumor samples Immunologic profile: analysis of the expression of relevant immunologic markers
  Retrospective clinical data collection:
  Patients' clinical data will be collected retrospectively from the patient medical record. This study is not a treatment evaluation. Patients' follow-up and treatment will be performed according to the center local practices or to the specificities of a clinical trial in which the patient would have been enrolled, depending on the recommendations given by the multidisciplinary molecular board, with the review of the tumor genetic profile.

Eligibility: Inclusion Criteria:
  -  Histologically or cytologically confirmed diagnosis of advanced (locally-advanced or metastatic) malignant tumor of any histological type
  -  Tumor sample available to determine the genetic profile: either archival tumor sample [FFPE (formalin fixed and paraffin embedded)] or perform a new biopsy on an accessible lesion (left at the investigator's appreciation). Please note that brain and bone lesions are not considered as accessible lesions.
  -  Patient must be covered by a medical insurance.
  -  Informed consent signed by the patient and/or by parents (or legal representative) for patients below 18.
  Exclusion Criteria:
  -  No tumor sample available.

Relevance to patient case: not relevant