Patient case: 64-year-old female with Lung adenocarcinoma. Genetic variant: ALK Fusion. Other conditions: Emphysema.

Clinical trial: The Use of CT Perfusion to Determine the Normalization Window Period in the Treatment of Advanced Primary Lung Adenocarcinoma With Endostar

Summary: To evaluate the change of blood perfusion before/after the use of Endostar, discuss the time sequence of Endostar TM in treating advanced lung adenocarcinoma in normalization window period.


Eligibility: Inclusion Criteria:
  -  Histologically or cytologically newly diagnosed as unresectable and metastasis advanced lung adenocarcinoma(Stage IV, Seventh Edition of the UICC/AJCC Classification for Lung Cancer).
  -  At least one measurable objective tumor lesion, spiral CT or PET-CT examination: the shortest diameter ≥2cm，and no obvious necrosis
  -  Life expectancy ≥12weeks
  -  Patients receive palliative radiotherapy for bone's pain relief; patients receive radiotherapy for brain metastasis、patients after brain transfer operation or radiation therapy are allowed to enter the research.
  -  18≤Patients'age ＜70 years.
  -  Electrocolonogram (ECOG) Score:0-1.
  -  Granulocyte count ≥ 2.0×109/L, platelet count ≥ 100×109/L.
  -  Serum bilirubin within the normal range.
  -  Aspartate aminotransferase ( AST ), Alanine aminotransferase ( ALT ) within the normal range(if the patients is diagonosed as liver metastasis,his/her AST/ALT should not surpass 1.5 times of the normal range ).
  -  Serum creatinine within the normal range and creatinine clearance rate ≥60ml/min
  -  Compliance with research requirements and be able to follow up.
  -  Within 72 hours before the treatment, all women pregnant with pregnant possibility should undergo pregnancy test and get negative results.
  -  Patients with fertility ability should take effective contraceptive techniques.
  -  Sign informed consent of this clinic trial.
  Exclusion Criteria:
  -  Lung adenocarcinoma patients who received systemic chemotherapy/thoracic radiotherapy/targeted therapy
  -  Received resection, cutting or aspiration within seven days
  -  Any unstable systemic diseases (including peptic ulcer、active infection、grade4 hypertension、unstable angina、congestive heart failure、liver, metabolic disorders or fracture、unhealing wound )
  -  Chronic kidney disease history(including chronic nephritis, nephrotic syndrome, Obstruction of urinary tract etc. caused by Urinary calculus)
  -  have to use anticoagulant drugs at the same time
  -  patients with obvious coagulation disorders、active bleeding and bleeding tendency
  -  Any other malignancies (complete cure of cervical carcinoma in situ/basal cell carcinoma/squamous cell carcinoma are excluded )happened within 5 years.
  -  Signifinant weight loss, weight lost during the 6 weeks more than or equal to 10%
  -  Patients who take bone metastasis as the only observing index
  -  Allergic to escherichia coli preparation
  -  Used Endostar before
  -  Lactating women
  -  Contraindications written on Pemetrexed、Carboplatin、Dexamethasone instructions
  -  Allergic to radiographic contrast agents
  -  In the middle or planning to attend other clinic trails

Relevance to patient case: not relevant