Patient case: 26-year-old female with Cervical cancer. Genetic variant: STK11. Other conditions: None.

Clinical trial: Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer

Summary: RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also help cisplatin work better by making tumor cells more sensitive to the drug. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving cetuximab together with cisplatin may be a better way to block tumor growth.
  PURPOSE: This phase II trial is studying how well giving cetuximab together with cisplatin works in treating patients with advanced, persistent, or recurrent cervical cancer.

Detailed description: OBJECTIVES:
  Primary
  -  Determine the antitumor activity of cetuximab and cisplatin, in terms of objective tumor response (partial and complete), in patients with advanced, persistent, or recurrent carcinoma of the cervix.
  -  Determine the nature and degree of toxicity of this regimen in these patients.
  Secondary
  -  Determine the progression-free survival and overall survival of patients treated with this regimen.
  -  Correlate epidermal growth factor receptor expression with progression-free survival, overall survival, and response in patients treated with this regimen.
  OUTLINE: This is a multicenter study.
  Patients receive cetuximab IV over 1-2 hours on days 1, 8, and 15 and cisplatin IV on days 1 and 8. Courses repeat every 21 days in the absence of unacceptable toxicity or disease progression.
  Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
  PROJECTED ACCRUAL: A total of 28-62 patients will be accrued for this study within 9-20 months.

Eligibility: DISEASE CHARACTERISTICS:
  -  Histologically confirmed squamous or non-squamous cell carcinoma of the cervix
  -  Advanced, persistent, or recurrent disease
  -  Documented disease progression
  -  Not amenable to curative therapy
  -  Measurable disease
  -  At least 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques OR ≥ 10 mm by spiral CT scan
  -  At least 1 target lesion
  -  Tumors within a previously irradiated field are designated as non-target lesions unless progression is documented or a biopsy is obtained ≥ 90 days after completion of radiotherapy to confirm persistence
  PATIENT CHARACTERISTICS:
  Age
  -  18 and over
  Performance status
  -  GOG 0-2
  Life expectancy
  -  Not specified
  Hematopoietic
  -  Platelet count ≥ 100,000/mm^3
  -  Absolute neutrophil count ≥ 1,500/mm^3
  Hepatic
  -  Bilirubin ≤ 1.5 times upper limit of normal (ULN)
  -  AST ≤ 2.5 times ULN
  -  Alkaline phosphatase ≤ 2.5 times ULN
  Renal
  -  Creatinine ≤ 1.5 times ULN
  Cardiovascular
  -  No significant history of cardiac disease within the past 6 months, including the following:
  -  Unstable angina
  -  Uncontrolled hypertension
  -  Uncontrolled congestive heart failure
  -  Uncontrolled arrhythmia
  Neurologic
  -  No uncontrolled seizure disorder
  -  No active neurological disease
  -  No neuropathy (sensory and motor) > grade 1
  Other
  -  Not pregnant or nursing
  -  Negative pregnancy test
  -  Fertile patients must use effective contraception
  -  No active infection requiring antibiotics
  -  No other invasive malignancy within the past 5 years except nonmelanoma skin cancer
  PRIOR CONCURRENT THERAPY:
  Biologic therapy
  -  No prior anti-epidermal growth factor receptor (EGFR) antibody therapy
  -  No prior chimerized or murine monoclonal antibody therapy
  Chemotherapy
  -  Not specified
  Endocrine therapy
  -  At least 1 week since prior anticancer hormonal therapy
  -  Concurrent hormone replacement therapy allowed
  Radiotherapy
  -  See Disease Characteristics
  -  At least 4 weeks since prior radiotherapy
  Surgery
  -  More than 30 days since prior major surgery, except diagnostic biopsy
  Other
  -  Recovered from all prior therapy
  -  No prior cytotoxic therapy for cervical cancer
  -  No prior tyrosine kinase inhibitor therapy that targets the EGFR pathway
  -  No prior cancer treatment that would contraindicate study therapy
  -  No other concurrent investigational agents

Relevance to patient case: not relevant